                         SEQUENCE LISTING

<110>  CeMM-Forschungsinstitut fr Molekulare Medizin GmbH 
 
<120>  WAVE1 inhibition in the medical intervention of inflammatory 
       diseases and/or infections caused by a pathogen

<130>  R2830 PCT S3

<160>  22    

<170>  PatentIn version 3.3

<210>  1
<211>  1680
<212>  DNA
<213>  Homo sapiens

<400>  1
atgccgctag tgaaaagaaa catcgatcct aggcacttgt gccacacagc actgcctaga     60

ggcattaaga atgaactgga atgtgtaacc aatatttcct tggcaaatat aattagacaa    120

ctaagtagcc taagtaaata tgctgaagat atatttggag aattattcaa tgaagcacat    180

agtttttcct tcagagtcaa ctcattgcaa gaacgtgtgg accgtttatc tgttagtgtt    240

acacagcttg atccaaagga agaagaattg tctttgcaag atataacaat gaggaaagct    300

ttccgaagtt ctacaattca agaccagcag cttttcgatc gcaagacttt gcctattcca    360

ttacaggaga cgtacgatgt ttgtgaacag cctccacctc tcaatatact cactccttat    420

agagatgatg gtaaagaagg tctgaagttt tataccaatc cttcgtattt ctttgatcta    480

tggaaagaaa aaatgttgca agatacagag gataagagga aggaaaagag gaagcagaag    540

cagaaaaatc tagatcgtcc tcatgaacca gaaaaagtgc caagagcacc tcatgacagg    600

cggcgagaat ggcagaagct ggcccaaggt ccagagctgg ctgaagatga tgctaatctc    660

ttacataagc atattgaagt tgctaatggc ccagcctctc attttgaaac aagacctcag    720

acatacgtgg atcatatgga tggatcttac tcactttctg ccttgccatt tagtcagatg    780

agtgagcttc tgactagagc tgaggaaagg gtattagtca gaccacatga accacctcca    840

cctccaccaa tgcatggagc aggagatgca aaaccgatac ccacctgtat cagttctgct    900

acaggtttga tagaaaatcg ccctcagtca ccagctacag gcagaacacc tgtgtttgtg    960

agccccactc ccccacctcc tccaccacct cttccatctg ccttgtcaac ttcctcatta   1020

agagcttcaa tgacttcaac tcctccccct ccagtacctc ccccacctcc acctccagcc   1080

actgctttgc aagctccagc agtaccacca cctccagctc ctcttcagat tgcccctgga   1140

gttcttcacc cagctcctcc tccaattgca cctcctctag tacagccctc tccaccagta   1200

gctagagctg ccccagtatg tgagactgta ccagttcatc cactcccaca aggtgaagtt   1260

caggggctgc ctccaccccc accaccgcct cctctgcctc cacctggcat tcgaccatca   1320

tcacctgtca cagttacagc tcttgctcat cctccctctg ggctacatcc aactccatct   1380

actgccccag gtccccatgt tccattaatg cctccatctc ctccatcaca agttatacct   1440

gcttctgagc caaagcgcca tccatcaacc ctacctgtaa tcagtgatgc caggagtgtg   1500

ctactggaag caatacgaaa aggtattcag ctacgcaaag tagaagagca gcgtgaacag   1560

gaagctaagc atgaacgcat tgaaaacgat gttgccacca tcctgtctcg ccgtattgct   1620

gttgaatata gtgattcgga agatgattca gaatttgatg aagtagattg gttggagtaa   1680


<210>  2
<211>  559
<212>  PRT
<213>  Homo sapiens

<400>  2

Met Pro Leu Val Lys Arg Asn Ile Asp Pro Arg His Leu Cys His Thr 
1               5                   10                  15      


Ala Leu Pro Arg Gly Ile Lys Asn Glu Leu Glu Cys Val Thr Asn Ile 
            20                  25                  30          


Ser Leu Ala Asn Ile Ile Arg Gln Leu Ser Ser Leu Ser Lys Tyr Ala 
        35                  40                  45              


Glu Asp Ile Phe Gly Glu Leu Phe Asn Glu Ala His Ser Phe Ser Phe 
    50                  55                  60                  


Arg Val Asn Ser Leu Gln Glu Arg Val Asp Arg Leu Ser Val Ser Val 
65                  70                  75                  80  


Thr Gln Leu Asp Pro Lys Glu Glu Glu Leu Ser Leu Gln Asp Ile Thr 
                85                  90                  95      


Met Arg Lys Ala Phe Arg Ser Ser Thr Ile Gln Asp Gln Gln Leu Phe 
            100                 105                 110         


Asp Arg Lys Thr Leu Pro Ile Pro Leu Gln Glu Thr Tyr Asp Val Cys 
        115                 120                 125             


Glu Gln Pro Pro Pro Leu Asn Ile Leu Thr Pro Tyr Arg Asp Asp Gly 
    130                 135                 140                 


Lys Glu Gly Leu Lys Phe Tyr Thr Asn Pro Ser Tyr Phe Phe Asp Leu 
145                 150                 155                 160 


Trp Lys Glu Lys Met Leu Gln Asp Thr Glu Asp Lys Arg Lys Glu Lys 
                165                 170                 175     


Arg Lys Gln Lys Gln Lys Asn Leu Asp Arg Pro His Glu Pro Glu Lys 
            180                 185                 190         


Val Pro Arg Ala Pro His Asp Arg Arg Arg Glu Trp Gln Lys Leu Ala 
        195                 200                 205             


Gln Gly Pro Glu Leu Ala Glu Asp Asp Ala Asn Leu Leu His Lys His 
    210                 215                 220                 


Ile Glu Val Ala Asn Gly Pro Ala Ser His Phe Glu Thr Arg Pro Gln 
225                 230                 235                 240 


Thr Tyr Val Asp His Met Asp Gly Ser Tyr Ser Leu Ser Ala Leu Pro 
                245                 250                 255     


Phe Ser Gln Met Ser Glu Leu Leu Thr Arg Ala Glu Glu Arg Val Leu 
            260                 265                 270         


Val Arg Pro His Glu Pro Pro Pro Pro Pro Pro Met His Gly Ala Gly 
        275                 280                 285             


Asp Ala Lys Pro Ile Pro Thr Cys Ile Ser Ser Ala Thr Gly Leu Ile 
    290                 295                 300                 


Glu Asn Arg Pro Gln Ser Pro Ala Thr Gly Arg Thr Pro Val Phe Val 
305                 310                 315                 320 


Ser Pro Thr Pro Pro Pro Pro Pro Pro Pro Leu Pro Ser Ala Leu Ser 
                325                 330                 335     


Thr Ser Ser Leu Arg Ala Ser Met Thr Ser Thr Pro Pro Pro Pro Val 
            340                 345                 350         


Pro Pro Pro Pro Pro Pro Pro Ala Thr Ala Leu Gln Ala Pro Ala Val 
        355                 360                 365             


Pro Pro Pro Pro Ala Pro Leu Gln Ile Ala Pro Gly Val Leu His Pro 
    370                 375                 380                 


Ala Pro Pro Pro Ile Ala Pro Pro Leu Val Gln Pro Ser Pro Pro Val 
385                 390                 395                 400 


Ala Arg Ala Ala Pro Val Cys Glu Thr Val Pro Val His Pro Leu Pro 
                405                 410                 415     


Gln Gly Glu Val Gln Gly Leu Pro Pro Pro Pro Pro Pro Pro Pro Leu 
            420                 425                 430         


Pro Pro Pro Gly Ile Arg Pro Ser Ser Pro Val Thr Val Thr Ala Leu 
        435                 440                 445             


Ala His Pro Pro Ser Gly Leu His Pro Thr Pro Ser Thr Ala Pro Gly 
    450                 455                 460                 


Pro His Val Pro Leu Met Pro Pro Ser Pro Pro Ser Gln Val Ile Pro 
465                 470                 475                 480 


Ala Ser Glu Pro Lys Arg His Pro Ser Thr Leu Pro Val Ile Ser Asp 
                485                 490                 495     


Ala Arg Ser Val Leu Leu Glu Ala Ile Arg Lys Gly Ile Gln Leu Arg 
            500                 505                 510         


Lys Val Glu Glu Gln Arg Glu Gln Glu Ala Lys His Glu Arg Ile Glu 
        515                 520                 525             


Asn Asp Val Ala Thr Ile Leu Ser Arg Arg Ile Ala Val Glu Tyr Ser 
    530                 535                 540                 


Asp Ser Glu Asp Asp Ser Glu Phe Asp Glu Val Asp Trp Leu Glu 
545                 550                 555                 


<210>  3
<211>  1680
<212>  DNA
<213>  Homo sapiens

<400>  3
atgccgctag tgaaaagaaa catcgatcct aggcacttgt gccacacagc actgcctaga     60

ggcattaaga atgaactgga atgtgtaacc aatatttcct tggcaaatat aattagacaa    120

ctaagtagcc taagtaaata tgctgaagat atatttggag aattattcaa tgaagcacat    180

agtttttcct tcagagtcaa ctcattgcaa gaacgtgtgg accgtttatc tgttagtgtt    240

acacagcttg atccaaagga agaagaattg tctttgcaag atataacaat gaggaaagct    300

ttccgaagtt ctacaattca agaccagcag cttttcgatc gcaagacttt gcctattcca    360

ttacaggaga cgtacgatgt ttgtgaacag cctccacctc tcaatatact cactccttat    420

agagatgatg gtaaagaagg tctgaagttt tataccaatc cttcgtattt ctttgatcta    480

tggaaagaaa aaatgttgca agatacagag gataagagga aggaaaagag gaagcagaag    540

cagaaaaatc tagatcgtcc tcatgaacca gaaaaagtgc caagagcacc tcatgacagg    600

cggcgagaat ggcagaagct ggcccaaggt ccagagctgg ctgaagatga tgctaatctc    660

ttacataagc atattgaagt tgctaatggc ccagcctctc attttgaaac aagacctcag    720

acatacgtgg atcatatgga tggatcttac tcactttctg ccttgccatt tagtcagatg    780

agtgagcttc tgactagagc tgaggaaagg gtattagtca gaccacatga accacctcca    840

cctccaccaa tgcatggagc aggagatgca aaaccgatac ccacctgtat cagttctgct    900

acaggtttga tagaaaatcg ccctcagtca ccagctacag gcagaacacc tgtgtttgtg    960

agccccactc ccccacctcc tccaccacct cttccatctg ccttgtcaac ttcctcatta   1020

agagcttcaa tgacttcaac tcctccccct ccagtacctc ccccacctcc acctccagcc   1080

actgctttgc aagctccagc agtaccacca cctccagctc ctcttcagat tgcccctgga   1140

gttcttcacc cagctcctcc tccaattgca cctcctctag tacagccctc tccaccagta   1200

gctagagctg ccccagtatg tgagactgta ccagttcatc cactcccaca aggtgaagtt   1260

caggggctgc ctccaccccc accaccgcct cctctgcctc cacctggcat tcgaccatca   1320

tcacctgtca cagttacagc tcttgctcat cctccctctg ggctacatcc aactccatct   1380

actgccccag gtccccatgt tccattaatg cctccatctc ctccatcaca agttatacct   1440

gcttctgagc caaagcgcca tccatcaacc ctacctgtaa tcagtgatgc caggagtgtg   1500

ctactggaag caatacgaaa aggtattcag ctacgcaaag tagaagagca gcgtgaacag   1560

gaagctaagc atgaacgcat tgaaaacgat gttgccacca tcctgtctcg ccgtattgct   1620

gttgaatata gtgattcgga agatgattca gaatttgatg aagtagattg gttggagtaa   1680


<210>  4
<211>  559
<212>  PRT
<213>  Homo Sapiens

<400>  4

Met Pro Leu Val Lys Arg Asn Ile Asp Pro Arg His Leu Cys His Thr 
1               5                   10                  15      


Ala Leu Pro Arg Gly Ile Lys Asn Glu Leu Glu Cys Val Thr Asn Ile 
            20                  25                  30          


Ser Leu Ala Asn Ile Ile Arg Gln Leu Ser Ser Leu Ser Lys Tyr Ala 
        35                  40                  45              


Glu Asp Ile Phe Gly Glu Leu Phe Asn Glu Ala His Ser Phe Ser Phe 
    50                  55                  60                  


Arg Val Asn Ser Leu Gln Glu Arg Val Asp Arg Leu Ser Val Ser Val 
65                  70                  75                  80  


Thr Gln Leu Asp Pro Lys Glu Glu Glu Leu Ser Leu Gln Asp Ile Thr 
                85                  90                  95      


Met Arg Lys Ala Phe Arg Ser Ser Thr Ile Gln Asp Gln Gln Leu Phe 
            100                 105                 110         


Asp Arg Lys Thr Leu Pro Ile Pro Leu Gln Glu Thr Tyr Asp Val Cys 
        115                 120                 125             


Glu Gln Pro Pro Pro Leu Asn Ile Leu Thr Pro Tyr Arg Asp Asp Gly 
    130                 135                 140                 


Lys Glu Gly Leu Lys Phe Tyr Thr Asn Pro Ser Tyr Phe Phe Asp Leu 
145                 150                 155                 160 


Trp Lys Glu Lys Met Leu Gln Asp Thr Glu Asp Lys Arg Lys Glu Lys 
                165                 170                 175     


Arg Lys Gln Lys Gln Lys Asn Leu Asp Arg Pro His Glu Pro Glu Lys 
            180                 185                 190         


Val Pro Arg Ala Pro His Asp Arg Arg Arg Glu Trp Gln Lys Leu Ala 
        195                 200                 205             


Gln Gly Pro Glu Leu Ala Glu Asp Asp Ala Asn Leu Leu His Lys His 
    210                 215                 220                 


Ile Glu Val Ala Asn Gly Pro Ala Ser His Phe Glu Thr Arg Pro Gln 
225                 230                 235                 240 


Thr Tyr Val Asp His Met Asp Gly Ser Tyr Ser Leu Ser Ala Leu Pro 
                245                 250                 255     


Phe Ser Gln Met Ser Glu Leu Leu Thr Arg Ala Glu Glu Arg Val Leu 
            260                 265                 270         


Val Arg Pro His Glu Pro Pro Pro Pro Pro Pro Met His Gly Ala Gly 
        275                 280                 285             


Asp Ala Lys Pro Ile Pro Thr Cys Ile Ser Ser Ala Thr Gly Leu Ile 
    290                 295                 300                 


Glu Asn Arg Pro Gln Ser Pro Ala Thr Gly Arg Thr Pro Val Phe Val 
305                 310                 315                 320 


Ser Pro Thr Pro Pro Pro Pro Pro Pro Pro Leu Pro Ser Ala Leu Ser 
                325                 330                 335     


Thr Ser Ser Leu Arg Ala Ser Met Thr Ser Thr Pro Pro Pro Pro Val 
            340                 345                 350         


Pro Pro Pro Pro Pro Pro Pro Ala Thr Ala Leu Gln Ala Pro Ala Val 
        355                 360                 365             


Pro Pro Pro Pro Ala Pro Leu Gln Ile Ala Pro Gly Val Leu His Pro 
    370                 375                 380                 


Ala Pro Pro Pro Ile Ala Pro Pro Leu Val Gln Pro Ser Pro Pro Val 
385                 390                 395                 400 


Ala Arg Ala Ala Pro Val Cys Glu Thr Val Pro Val His Pro Leu Pro 
                405                 410                 415     


Gln Gly Glu Val Gln Gly Leu Pro Pro Pro Pro Pro Pro Pro Pro Leu 
            420                 425                 430         


Pro Pro Pro Gly Ile Arg Pro Ser Ser Pro Val Thr Val Thr Ala Leu 
        435                 440                 445             


Ala His Pro Pro Ser Gly Leu His Pro Thr Pro Ser Thr Ala Pro Gly 
    450                 455                 460                 


Pro His Val Pro Leu Met Pro Pro Ser Pro Pro Ser Gln Val Ile Pro 
465                 470                 475                 480 


Ala Ser Glu Pro Lys Arg His Pro Ser Thr Leu Pro Val Ile Ser Asp 
                485                 490                 495     


Ala Arg Ser Val Leu Leu Glu Ala Ile Arg Lys Gly Ile Gln Leu Arg 
            500                 505                 510         


Lys Val Glu Glu Gln Arg Glu Gln Glu Ala Lys His Glu Arg Ile Glu 
        515                 520                 525             


Asn Asp Val Ala Thr Ile Leu Ser Arg Arg Ile Ala Val Glu Tyr Ser 
    530                 535                 540                 


Asp Ser Glu Asp Asp Ser Glu Phe Asp Glu Val Asp Trp Leu Glu 
545                 550                 555                 


<210>  5
<211>  1680
<212>  DNA
<213>  Homo sapiens

<400>  5
atgccgctag tgaaaagaaa catcgatcct aggcacttgt gccacacagc actgcctaga     60

ggcattaaga atgaactgga atgtgtaacc aatatttcct tggcaaatat aattagacaa    120

ctaagtagcc taagtaaata tgctgaagat atatttggag aattattcaa tgaagcacat    180

agtttttcct tcagagtcaa ctcattgcaa gaacgtgtgg accgtttatc tgttagtgtt    240

acacagcttg atccaaagga agaagaattg tctttgcaag atataacaat gaggaaagct    300

ttccgaagtt ctacaattca agaccagcag cttttcgatc gcaagacttt gcctattcca    360

ttacaggaga cgtacgatgt ttgtgaacag cctccacctc tcaatatact cactccttat    420

agagatgatg gtaaagaagg tctgaagttt tataccaatc cttcgtattt ctttgatcta    480

tggaaagaaa aaatgttgca agatacagag gataagagga aggaaaagag gaagcagaag    540

cagaaaaatc tagatcgtcc tcatgaacca gaaaaagtgc caagagcacc tcatgacagg    600

cggcgagaat ggcagaagct ggcccaaggt ccagagctgg ctgaagatga tgctaatctc    660

ttacataagc atattgaagt tgctaatggc ccagcctctc attttgaaac aagacctcag    720

acatacgtgg atcatatgga tggatcttac tcactttctg ccttgccatt tagtcagatg    780

agtgagcttc tgactagagc tgaggaaagg gtattagtca gaccacatga accacctcca    840

cctccaccaa tgcatggagc aggagatgca aaaccgatac ccacctgtat cagttctgct    900

acaggtttga tagaaaatcg ccctcagtca ccagctacag gcagaacacc tgtgtttgtg    960

agccccactc ccccacctcc tccaccacct cttccatctg ccttgtcaac ttcctcatta   1020

agagcttcaa tgacttcaac tcctccccct ccagtacctc ccccacctcc acctccagcc   1080

actgctttgc aagctccagc agtaccacca cctccagctc ctcttcagat tgcccctgga   1140

gttcttcacc cagctcctcc tccaattgca cctcctctag tacagccctc tccaccagta   1200

gctagagctg ccccagtatg tgagactgta ccagttcatc cactcccaca aggtgaagtt   1260

caggggctgc ctccaccccc accaccgcct cctctgcctc cacctggcat tcgaccatca   1320

tcacctgtca cagttacagc tcttgctcat cctccctctg ggctacatcc aactccatct   1380

actgccccag gtccccatgt tccattaatg cctccatctc ctccatcaca agttatacct   1440

gcttctgagc caaagcgcca tccatcaacc ctacctgtaa tcagtgatgc caggagtgtg   1500

ctactggaag caatacgaaa aggtattcag ctacgcaaag tagaagagca gcgtgaacag   1560

gaagctaagc atgaacgcat tgaaaacgat gttgccacca tcctgtctcg ccgtattgct   1620

gttgaatata gtgattcgga agatgattca gaatttgatg aagtagattg gttggagtaa   1680


<210>  6
<211>  559
<212>  PRT
<213>  Homo sapiens

<400>  6

Met Pro Leu Val Lys Arg Asn Ile Asp Pro Arg His Leu Cys His Thr 
1               5                   10                  15      


Ala Leu Pro Arg Gly Ile Lys Asn Glu Leu Glu Cys Val Thr Asn Ile 
            20                  25                  30          


Ser Leu Ala Asn Ile Ile Arg Gln Leu Ser Ser Leu Ser Lys Tyr Ala 
        35                  40                  45              


Glu Asp Ile Phe Gly Glu Leu Phe Asn Glu Ala His Ser Phe Ser Phe 
    50                  55                  60                  


Arg Val Asn Ser Leu Gln Glu Arg Val Asp Arg Leu Ser Val Ser Val 
65                  70                  75                  80  


Thr Gln Leu Asp Pro Lys Glu Glu Glu Leu Ser Leu Gln Asp Ile Thr 
                85                  90                  95      


Met Arg Lys Ala Phe Arg Ser Ser Thr Ile Gln Asp Gln Gln Leu Phe 
            100                 105                 110         


Asp Arg Lys Thr Leu Pro Ile Pro Leu Gln Glu Thr Tyr Asp Val Cys 
        115                 120                 125             


Glu Gln Pro Pro Pro Leu Asn Ile Leu Thr Pro Tyr Arg Asp Asp Gly 
    130                 135                 140                 


Lys Glu Gly Leu Lys Phe Tyr Thr Asn Pro Ser Tyr Phe Phe Asp Leu 
145                 150                 155                 160 


Trp Lys Glu Lys Met Leu Gln Asp Thr Glu Asp Lys Arg Lys Glu Lys 
                165                 170                 175     


Arg Lys Gln Lys Gln Lys Asn Leu Asp Arg Pro His Glu Pro Glu Lys 
            180                 185                 190         


Val Pro Arg Ala Pro His Asp Arg Arg Arg Glu Trp Gln Lys Leu Ala 
        195                 200                 205             


Gln Gly Pro Glu Leu Ala Glu Asp Asp Ala Asn Leu Leu His Lys His 
    210                 215                 220                 


Ile Glu Val Ala Asn Gly Pro Ala Ser His Phe Glu Thr Arg Pro Gln 
225                 230                 235                 240 


Thr Tyr Val Asp His Met Asp Gly Ser Tyr Ser Leu Ser Ala Leu Pro 
                245                 250                 255     


Phe Ser Gln Met Ser Glu Leu Leu Thr Arg Ala Glu Glu Arg Val Leu 
            260                 265                 270         


Val Arg Pro His Glu Pro Pro Pro Pro Pro Pro Met His Gly Ala Gly 
        275                 280                 285             


Asp Ala Lys Pro Ile Pro Thr Cys Ile Ser Ser Ala Thr Gly Leu Ile 
    290                 295                 300                 


Glu Asn Arg Pro Gln Ser Pro Ala Thr Gly Arg Thr Pro Val Phe Val 
305                 310                 315                 320 


Ser Pro Thr Pro Pro Pro Pro Pro Pro Pro Leu Pro Ser Ala Leu Ser 
                325                 330                 335     


Thr Ser Ser Leu Arg Ala Ser Met Thr Ser Thr Pro Pro Pro Pro Val 
            340                 345                 350         


Pro Pro Pro Pro Pro Pro Pro Ala Thr Ala Leu Gln Ala Pro Ala Val 
        355                 360                 365             


Pro Pro Pro Pro Ala Pro Leu Gln Ile Ala Pro Gly Val Leu His Pro 
    370                 375                 380                 


Ala Pro Pro Pro Ile Ala Pro Pro Leu Val Gln Pro Ser Pro Pro Val 
385                 390                 395                 400 


Ala Arg Ala Ala Pro Val Cys Glu Thr Val Pro Val His Pro Leu Pro 
                405                 410                 415     


Gln Gly Glu Val Gln Gly Leu Pro Pro Pro Pro Pro Pro Pro Pro Leu 
            420                 425                 430         


Pro Pro Pro Gly Ile Arg Pro Ser Ser Pro Val Thr Val Thr Ala Leu 
        435                 440                 445             


Ala His Pro Pro Ser Gly Leu His Pro Thr Pro Ser Thr Ala Pro Gly 
    450                 455                 460                 


Pro His Val Pro Leu Met Pro Pro Ser Pro Pro Ser Gln Val Ile Pro 
465                 470                 475                 480 


Ala Ser Glu Pro Lys Arg His Pro Ser Thr Leu Pro Val Ile Ser Asp 
                485                 490                 495     


Ala Arg Ser Val Leu Leu Glu Ala Ile Arg Lys Gly Ile Gln Leu Arg 
            500                 505                 510         


Lys Val Glu Glu Gln Arg Glu Gln Glu Ala Lys His Glu Arg Ile Glu 
        515                 520                 525             


Asn Asp Val Ala Thr Ile Leu Ser Arg Arg Ile Ala Val Glu Tyr Ser 
    530                 535                 540                 


Asp Ser Glu Asp Asp Ser Glu Phe Asp Glu Val Asp Trp Leu Glu 
545                 550                 555                 


<210>  7
<211>  1680
<212>  DNA
<213>  Homo sapiens

<400>  7
atgccgctag tgaaaagaaa catcgatcct aggcacttgt gccacacagc actgcctaga     60

ggcattaaga atgaactgga atgtgtaacc aatatttcct tggcaaatat aattagacaa    120

ctaagtagcc taagtaaata tgctgaagat atatttggag aattattcaa tgaagcacat    180

agtttttcct tcagagtcaa ctcattgcaa gaacgtgtgg accgtttatc tgttagtgtt    240

acacagcttg atccaaagga agaagaattg tctttgcaag atataacaat gaggaaagct    300

ttccgaagtt ctacaattca agaccagcag cttttcgatc gcaagacttt gcctattcca    360

ttacaggaga cgtacgatgt ttgtgaacag cctccacctc tcaatatact cactccttat    420

agagatgatg gtaaagaagg tctgaagttt tataccaatc cttcgtattt ctttgatcta    480

tggaaagaaa aaatgttgca agatacagag gataagagga aggaaaagag gaagcagaag    540

cagaaaaatc tagatcgtcc tcatgaacca gaaaaagtgc caagagcacc tcatgacagg    600

cggcgagaat ggcagaagct ggcccaaggt ccagagctgg ctgaagatga tgctaatctc    660

ttacataagc atattgaagt tgctaatggc ccagcctctc attttgaaac aagacctcag    720

acatacgtgg atcatatgga tggatcttac tcactttctg ccttgccatt tagtcagatg    780

agtgagcttc tgactagagc tgaggaaagg gtattagtca gaccacatga accacctcca    840

cctccaccaa tgcatggagc aggagatgca aaaccgatac ccacctgtat cagttctgct    900

acaggtttga tagaaaatcg ccctcagtca ccagctacag gcagaacacc tgtgtttgtg    960

agccccactc ccccacctcc tccaccacct cttccatctg ccttgtcaac ttcctcatta   1020

agagcttcaa tgacttcaac tcctccccct ccagtacctc ccccacctcc acctccagcc   1080

actgctttgc aagctccagc agtaccacca cctccagctc ctcttcagat tgcccctgga   1140

gttcttcacc cagctcctcc tccaattgca cctcctctag tacagccctc tccaccagta   1200

gctagagctg ccccagtatg tgagactgta ccagttcatc cactcccaca aggtgaagtt   1260

caggggctgc ctccaccccc accaccgcct cctctgcctc cacctggcat tcgaccatca   1320

tcacctgtca cagttacagc tcttgctcat cctccctctg ggctacatcc aactccatct   1380

actgccccag gtccccatgt tccattaatg cctccatctc ctccatcaca agttatacct   1440

gcttctgagc caaagcgcca tccatcaacc ctacctgtaa tcagtgatgc caggagtgtg   1500

ctactggaag caatacgaaa aggtattcag ctacgcaaag tagaagagca gcgtgaacag   1560

gaagctaagc atgaacgcat tgaaaacgat gttgccacca tcctgtctcg ccgtattgct   1620

gttgaatata gtgattcgga agatgattca gaatttgatg aagtagattg gttggagtaa   1680


<210>  8
<211>  559
<212>  PRT
<213>  Homo sapiens

<400>  8

Met Pro Leu Val Lys Arg Asn Ile Asp Pro Arg His Leu Cys His Thr 
1               5                   10                  15      


Ala Leu Pro Arg Gly Ile Lys Asn Glu Leu Glu Cys Val Thr Asn Ile 
            20                  25                  30          


Ser Leu Ala Asn Ile Ile Arg Gln Leu Ser Ser Leu Ser Lys Tyr Ala 
        35                  40                  45              


Glu Asp Ile Phe Gly Glu Leu Phe Asn Glu Ala His Ser Phe Ser Phe 
    50                  55                  60                  


Arg Val Asn Ser Leu Gln Glu Arg Val Asp Arg Leu Ser Val Ser Val 
65                  70                  75                  80  


Thr Gln Leu Asp Pro Lys Glu Glu Glu Leu Ser Leu Gln Asp Ile Thr 
                85                  90                  95      


Met Arg Lys Ala Phe Arg Ser Ser Thr Ile Gln Asp Gln Gln Leu Phe 
            100                 105                 110         


Asp Arg Lys Thr Leu Pro Ile Pro Leu Gln Glu Thr Tyr Asp Val Cys 
        115                 120                 125             


Glu Gln Pro Pro Pro Leu Asn Ile Leu Thr Pro Tyr Arg Asp Asp Gly 
    130                 135                 140                 


Lys Glu Gly Leu Lys Phe Tyr Thr Asn Pro Ser Tyr Phe Phe Asp Leu 
145                 150                 155                 160 


Trp Lys Glu Lys Met Leu Gln Asp Thr Glu Asp Lys Arg Lys Glu Lys 
                165                 170                 175     


Arg Lys Gln Lys Gln Lys Asn Leu Asp Arg Pro His Glu Pro Glu Lys 
            180                 185                 190         


Val Pro Arg Ala Pro His Asp Arg Arg Arg Glu Trp Gln Lys Leu Ala 
        195                 200                 205             


Gln Gly Pro Glu Leu Ala Glu Asp Asp Ala Asn Leu Leu His Lys His 
    210                 215                 220                 


Ile Glu Val Ala Asn Gly Pro Ala Ser His Phe Glu Thr Arg Pro Gln 
225                 230                 235                 240 


Thr Tyr Val Asp His Met Asp Gly Ser Tyr Ser Leu Ser Ala Leu Pro 
                245                 250                 255     


Phe Ser Gln Met Ser Glu Leu Leu Thr Arg Ala Glu Glu Arg Val Leu 
            260                 265                 270         


Val Arg Pro His Glu Pro Pro Pro Pro Pro Pro Met His Gly Ala Gly 
        275                 280                 285             


Asp Ala Lys Pro Ile Pro Thr Cys Ile Ser Ser Ala Thr Gly Leu Ile 
    290                 295                 300                 


Glu Asn Arg Pro Gln Ser Pro Ala Thr Gly Arg Thr Pro Val Phe Val 
305                 310                 315                 320 


Ser Pro Thr Pro Pro Pro Pro Pro Pro Pro Leu Pro Ser Ala Leu Ser 
                325                 330                 335     


Thr Ser Ser Leu Arg Ala Ser Met Thr Ser Thr Pro Pro Pro Pro Val 
            340                 345                 350         


Pro Pro Pro Pro Pro Pro Pro Ala Thr Ala Leu Gln Ala Pro Ala Val 
        355                 360                 365             


Pro Pro Pro Pro Ala Pro Leu Gln Ile Ala Pro Gly Val Leu His Pro 
    370                 375                 380                 


Ala Pro Pro Pro Ile Ala Pro Pro Leu Val Gln Pro Ser Pro Pro Val 
385                 390                 395                 400 


Ala Arg Ala Ala Pro Val Cys Glu Thr Val Pro Val His Pro Leu Pro 
                405                 410                 415     


Gln Gly Glu Val Gln Gly Leu Pro Pro Pro Pro Pro Pro Pro Pro Leu 
            420                 425                 430         


Pro Pro Pro Gly Ile Arg Pro Ser Ser Pro Val Thr Val Thr Ala Leu 
        435                 440                 445             


Ala His Pro Pro Ser Gly Leu His Pro Thr Pro Ser Thr Ala Pro Gly 
    450                 455                 460                 


Pro His Val Pro Leu Met Pro Pro Ser Pro Pro Ser Gln Val Ile Pro 
465                 470                 475                 480 


Ala Ser Glu Pro Lys Arg His Pro Ser Thr Leu Pro Val Ile Ser Asp 
                485                 490                 495     


Ala Arg Ser Val Leu Leu Glu Ala Ile Arg Lys Gly Ile Gln Leu Arg 
            500                 505                 510         


Lys Val Glu Glu Gln Arg Glu Gln Glu Ala Lys His Glu Arg Ile Glu 
        515                 520                 525             


Asn Asp Val Ala Thr Ile Leu Ser Arg Arg Ile Ala Val Glu Tyr Ser 
    530                 535                 540                 


Asp Ser Glu Asp Asp Ser Glu Phe Asp Glu Val Asp Trp Leu Glu 
545                 550                 555                 


<210>  9
<211>  56
<212>  DNA
<213>  artificial sequence

<220>
<223>  /note="Description of artificial sequence: WAVE1shRNA"

<400>  9
accggaccga ttgtctgtta gtttcaagag aactaacaga caatcggtcc tttttc         56


<210>  10
<211>  56
<212>  DNA
<213>  artificial sequence

<220>
<223>  /note="Description of artificial sequence: phosphorylated 
       WAVE1shRNA"

<400>  10
accggaccga ttgtctgtta gtttcaagag aactaacaga caatcggtcc tttttc         56


<210>  11
<211>  22
<212>  PRT
<213>  artificial sequence

<220>
<223>  /note="Description of artificial sequence: Ht-31 AKAP inhibitory 
       peptide"

<400>  11

Asp Leu Ile Glu Glu Ala Ala Ser Arg Ile Val Asp Ala Val Ile Glu 
1               5                   10                  15      


Gln Val Lys Ala Ala Tyr 
            20          


<210>  12
<211>  56
<212>  DNA
<213>  artificial sequence

<220>
<223>  /note="Description of artificial sequence: PKAc shRNA"

<400>  12
accggtggaa gctcccttca tattcaagag atatgaaggg agcttccacc tttttc         56


<210>  13
<211>  56
<212>  DNA
<213>  artificial sequence

<220>
<223>  /note="Description of artificial sequence: PKAc SCR"

<400>  13
accgacggca gtgcttcaca ttttcaagag aaatgtgaag cactgccgtc tttttc         56


<210>  14
<211>  56
<212>  DNA
<213>  artificial sequence

<220>
<223>  /note="Description of artificial sequence: WAVE1 SCR)"

<400>  14
accgtctggc aacgattttg gtttcaagag aaccaaaatc gttgccagac tttttc         56


<210>  15
<211>  18
<212>  DNA
<213>  artificial sequence

<220>
<223>  /note="Description of artificial sequence: primer WAVE1 (sense)"

<400>  15
ggaagcgccg tcctcttg                                                   18


<210>  16
<211>  18
<212>  DNA
<213>  artificial sequence

<220>
<223>  /note="Description of artificial sequence: primer WAVE1 
       (anti-sense)"

<400>  16
ctgggcagtg ctgtgtgg                                                   18


<210>  17
<211>  19
<212>  DNA
<213>  artificial sequence

<220>
<223>  /note="Description of artificial sequence: primer AKAP-Lbc 
       (sense)"

<400>  17
cgcacgtgtc ctgggtcat                                                  19


<210>  18
<211>  25
<212>  DNA
<213>  artificial sequence

<220>
<223>  /note="Description of artificial sequence: primer AKAP-Lbc 
       (anti-sense)"

<400>  18
tgcagtgata gagggtagag ccaga                                           25


<210>  19
<211>  20
<212>  DNA
<213>  artificial sequence

<220>
<223>  /note="Description of artificial sequence: primer Gravin (sense)"

<400>  19
cgtcgggagc agctggagat                                                 20


<210>  20
<211>  20
<212>  DNA
<213>  artificial sequence

<220>
<223>  /note="Description of artificial sequence: primer Gravin 
       (anti-sense)"

<400>  20
tgcccatcct ggctttcctc                                                 20


<210>  21
<211>  23
<212>  DNA
<213>  artificial sequence

<220>
<223>  /note="Description of artificial sequence: primer HPRT (sense)"

<400>  21
gttaagcagt acagccccaa aag                                             23


<210>  22
<211>  24
<212>  DNA
<213>  artificial sequence

<220>
<223>  /note="Description of artificial sequence: primer HPRT 
       (anti-sense)"

<400>  22
aaatccaaca aagtctggcc tgta                                            24


