                         SEQUENZPROTOKOLL

<110>  Orthogen AG
 
<120>  Kombinationsprparate mit Cytokin-Antagonist und Corticosteroid

<130>  52 252 K

<160>  8     

<170>  PatentIn version 3.3

<210>  1
<211>  177
<212>  PRT
<213>  Homo sapiens

<400>  1

Met Glu Ile Cys Arg Gly Leu Arg Ser His Leu Ile Thr Leu Leu Leu 
1               5                   10                  15      


Phe Leu Phe His Ser Glu Thr Ile Cys Arg Pro Ser Gly Arg Lys Ser 
            20                  25                  30          


Ser Lys Met Gln Ala Phe Arg Ile Trp Asp Val Asn Gln Lys Thr Phe 
        35                  40                  45              


Tyr Leu Arg Asn Asn Gln Leu Val Ala Gly Tyr Leu Gln Gly Pro Asn 
    50                  55                  60                  


Val Asn Leu Glu Glu Lys Ile Asp Val Val Pro Ile Glu Pro His Ala 
65                  70                  75                  80  


Leu Phe Leu Gly Ile His Gly Gly Lys Met Cys Leu Ser Cys Val Lys 
                85                  90                  95      


Ser Gly Asp Glu Thr Arg Leu Gln Leu Glu Ala Val Asn Ile Thr Asp 
            100                 105                 110         


Leu Ser Glu Asn Arg Lys Gln Asp Lys Arg Phe Ala Phe Ile Arg Ser 
        115                 120                 125             


Asp Ser Gly Pro Thr Thr Ser Phe Glu Ser Ala Ala Cys Pro Gly Trp 
    130                 135                 140                 


Phe Leu Cys Thr Ala Met Glu Ala Asp Gln Pro Val Ser Leu Thr Asn 
145                 150                 155                 160 


Met Pro Asp Glu Gly Val Met Val Thr Lys Phe Tyr Phe Gln Glu Asp 
                165                 170                 175     


Glu 
    


<210>  2
<211>  159
<212>  PRT
<213>  Homo sapiens

<400>  2

Met Ala Leu Glu Thr Ile Cys Arg Pro Ser Gly Arg Lys Ser Ser Lys 
1               5                   10                  15      


Met Gln Ala Phe Arg Ile Trp Asp Val Asn Gln Lys Thr Phe Tyr Leu 
            20                  25                  30          


Arg Asn Asn Gln Leu Val Ala Gly Tyr Leu Gln Gly Pro Asn Val Asn 
        35                  40                  45              


Leu Glu Glu Lys Ile Asp Val Val Pro Ile Glu Pro His Ala Leu Phe 
    50                  55                  60                  


Leu Gly Ile His Gly Gly Lys Met Cys Leu Ser Cys Val Lys Ser Gly 
65                  70                  75                  80  


Asp Glu Thr Arg Leu Gln Leu Glu Ala Val Asn Ile Thr Asp Leu Ser 
                85                  90                  95      


Glu Asn Arg Lys Gln Asp Lys Arg Phe Ala Phe Ile Arg Ser Asp Ser 
            100                 105                 110         


Gly Pro Thr Thr Ser Phe Glu Ser Ala Ala Cys Pro Gly Trp Phe Leu 
        115                 120                 125             


Cys Thr Ala Met Glu Ala Asp Gln Pro Val Ser Leu Thr Asn Met Pro 
    130                 135                 140                 


Asp Glu Gly Val Met Val Thr Lys Phe Tyr Phe Gln Glu Asp Glu 
145                 150                 155                 


<210>  3
<211>  180
<212>  PRT
<213>  Homo sapiens

<400>  3

Met Ala Leu Ala Asp Leu Tyr Glu Glu Gly Gly Gly Gly Gly Gly Glu 
1               5                   10                  15      


Gly Glu Asp Asn Ala Asp Ser Lys Glu Thr Ile Cys Arg Pro Ser Gly 
            20                  25                  30          


Arg Lys Ser Ser Lys Met Gln Ala Phe Arg Ile Trp Asp Val Asn Gln 
        35                  40                  45              


Lys Thr Phe Tyr Leu Arg Asn Asn Gln Leu Val Ala Gly Tyr Leu Gln 
    50                  55                  60                  


Gly Pro Asn Val Asn Leu Glu Glu Lys Ile Asp Val Val Pro Ile Glu 
65                  70                  75                  80  


Pro His Ala Leu Phe Leu Gly Ile His Gly Gly Lys Met Cys Leu Ser 
                85                  90                  95      


Cys Val Lys Ser Gly Asp Glu Thr Arg Leu Gln Leu Glu Ala Val Asn 
            100                 105                 110         


Ile Thr Asp Leu Ser Glu Asn Arg Lys Gln Asp Lys Arg Phe Ala Phe 
        115                 120                 125             


Ile Arg Ser Asp Ser Gly Pro Thr Thr Ser Phe Glu Ser Ala Ala Cys 
    130                 135                 140                 


Pro Gly Trp Phe Leu Cys Thr Ala Met Glu Ala Asp Gln Pro Val Ser 
145                 150                 155                 160 


Leu Thr Asn Met Pro Asp Glu Gly Val Met Val Thr Lys Phe Tyr Phe 
                165                 170                 175     


Gln Glu Asp Glu 
            180 


<210>  4
<211>  143
<212>  PRT
<213>  Homo sapiens

<400>  4

Met Gln Ala Phe Arg Ile Trp Asp Val Asn Gln Lys Thr Phe Tyr Leu 
1               5                   10                  15      


Arg Asn Asn Gln Leu Val Ala Gly Tyr Leu Gln Gly Pro Asn Val Asn 
            20                  25                  30          


Leu Glu Glu Lys Ile Asp Val Val Pro Ile Glu Pro His Ala Leu Phe 
        35                  40                  45              


Leu Gly Ile His Gly Gly Lys Met Cys Leu Ser Cys Val Lys Ser Gly 
    50                  55                  60                  


Asp Glu Thr Arg Leu Gln Leu Glu Ala Val Asn Ile Thr Asp Leu Ser 
65                  70                  75                  80  


Glu Asn Arg Lys Gln Asp Lys Arg Phe Ala Phe Ile Arg Ser Asp Ser 
                85                  90                  95      


Gly Pro Thr Thr Ser Phe Glu Ser Ala Ala Cys Pro Gly Trp Phe Leu 
            100                 105                 110         


Cys Thr Ala Met Glu Ala Asp Gln Pro Val Ser Leu Thr Asn Met Pro 
        115                 120                 125             


Asp Glu Gly Val Met Val Thr Lys Phe Tyr Phe Gln Glu Asp Glu 
    130                 135                 140             


<210>  5
<211>  155
<212>  PRT
<213>  Homo sapiens

<400>  5

Met Val Leu Ser Gly Ala Leu Cys Phe Arg Met Lys Asp Ser Ala Leu 
1               5                   10                  15      


Lys Val Leu Tyr Leu His Asn Asn Gln Leu Leu Ala Gly Gly Leu His 
            20                  25                  30          


Ala Gly Lys Val Ile Lys Gly Glu Glu Ile Ser Val Val Pro Asn Arg 
        35                  40                  45              


Trp Leu Asp Ala Ser Leu Ser Pro Val Ile Leu Gly Val Gln Gly Gly 
    50                  55                  60                  


Ser Gln Cys Leu Ser Cys Gly Val Gly Gln Glu Pro Thr Leu Thr Leu 
65                  70                  75                  80  


Glu Pro Val Asn Ile Met Glu Leu Tyr Leu Gly Ala Lys Glu Ser Lys 
                85                  90                  95      


Ser Phe Thr Phe Tyr Arg Arg Asp Met Gly Leu Thr Ser Ser Phe Glu 
            100                 105                 110         


Ser Ala Ala Tyr Pro Gly Trp Phe Leu Cys Thr Val Pro Glu Ala Asp 
        115                 120                 125             


Gln Pro Val Arg Leu Thr Gln Leu Pro Glu Asn Gly Gly Trp Asn Ala 
    130                 135                 140                 


Pro Ile Thr Asp Phe Tyr Phe Gln Gln Cys Asp 
145                 150                 155 


<210>  6
<211>  177
<212>  PRT
<213>  Equus caballus

<400>  6

Met Glu Ile Arg Arg Arg Ser Val Arg His Leu Ile Ser Leu Leu Leu 
1               5                   10                  15      


Phe Leu Phe Tyr Ser Glu Thr Ala Cys His Pro Leu Gly Lys Arg Pro 
            20                  25                  30          


Cys Lys Met Gln Ala Phe Arg Ile Trp Asp Val Asn Gln Lys Thr Phe 
        35                  40                  45              


Tyr Met Arg Asn Asn Gln Leu Val Ala Gly Tyr Leu Gln Glu Ser Asn 
    50                  55                  60                  


Thr Lys Leu Gln Glu Lys Ile Asp Val Val Pro Ile Glu Pro Asp Ala 
65                  70                  75                  80  


Leu Phe Leu Gly Leu His Gly Arg Lys Leu Cys Leu Ala Cys Val Lys 
                85                  90                  95      


Ser Gly Asp Glu Ile Arg Phe Gln Leu Glu Ala Val Asn Ile Thr Asp 
            100                 105                 110         


Leu Ser Lys Asn Lys Glu Glu Asn Lys Arg Phe Thr Phe Ile Arg Ser 
        115                 120                 125             


Asn Ser Gly Pro Thr Thr Ser Phe Glu Ser Ala Ala Cys Pro Gly Trp 
    130                 135                 140                 


Phe Leu Cys Thr Ala Gln Glu Ala Asp Arg Pro Val Ser Leu Thr Asn 
145                 150                 155                 160 


Lys Pro Lys Glu Ser Phe Met Val Thr Lys Phe Tyr Leu Gln Glu Asp 
                165                 170                 175     


Gln 
    


<210>  7
<211>  177
<212>  PRT
<213>  Equus caballus

<400>  7

Met Glu Ile Arg Arg Arg Ser Val Arg His Leu Ile Ser Leu Leu Leu 
1               5                   10                  15      


Phe Leu Leu Tyr Ser Glu Thr Ala Cys His Pro Leu Gly Lys Arg Pro 
            20                  25                  30          


Cys Lys Met Gln Ala Phe Arg Ile Trp Asp Val Asn Gln Lys Thr Phe 
        35                  40                  45              


Tyr Met Arg Asn Asn Gln Leu Val Ala Gly Tyr Leu Gln Glu Ser Asn 
    50                  55                  60                  


Thr Lys Leu Gln Glu Lys Ile Asp Val Val Pro Ile Glu Pro Asp Ala 
65                  70                  75                  80  


Leu Phe Leu Gly Leu His Gly Arg Lys Leu Cys Leu Ala Cys Val Lys 
                85                  90                  95      


Ser Gly Asp Glu Ile Arg Phe Gln Leu Glu Ala Val Asn Ile Thr Asp 
            100                 105                 110         


Leu Ser Lys Asn Lys Glu Glu Asn Lys Arg Phe Thr Phe Ile Arg Ser 
        115                 120                 125             


Asn Ser Gly Pro Thr Thr Ser Phe Glu Ser Ala Ala Cys Pro Gly Trp 
    130                 135                 140                 


Phe Leu Cys Thr Ala Gln Glu Ala Asp Arg Pro Val Ser Leu Thr Asn 
145                 150                 155                 160 


Lys Pro Lys Glu Ser Phe Met Val Thr Lys Phe Tyr Leu Gln Glu Asp 
                165                 170                 175     


Gln 
    


<210>  8
<211>  176
<212>  PRT
<213>  Canis familiaris

<400>  8

Met Glu Thr Cys Arg Cys Pro Leu Ser Tyr Leu Ile Ser Phe Leu Leu 
1               5                   10                  15      


Phe Leu Ser His Ser Glu Thr Ala Cys Arg Pro Leu Gly Lys Arg Pro 
            20                  25                  30          


Cys Arg Met Gln Ala Phe Arg Ile Trp Asp Val Asn Gln Lys Thr Phe 
        35                  40                  45              


Tyr Leu Arg Asn Asn Gln Leu Val Ala Gly Tyr Leu Gln Gly Ser Asn 
    50                  55                  60                  


Thr Lys Leu Glu Glu Lys Leu Asp Val Val Pro Val Glu Pro His Ala 
65                  70                  75                  80  


Val Phe Leu Gly Ile His Gly Gly Lys Leu Cys Leu Ala Cys Val Lys 
                85                  90                  95      


Ser Gly Asp Glu Thr Arg Leu Gln Leu Glu Ala Val Asn Ile Thr Asp 
            100                 105                 110         


Leu Ser Lys Asn Lys Asp Gln Asp Lys Arg Phe Thr Phe Ile Leu Ser 
        115                 120                 125             


Asp Ser Gly Pro Thr Thr Ser Phe Glu Ser Ala Ala Cys Pro Gly Trp 
    130                 135                 140                 


Phe Leu Cys Thr Ala Leu Glu Ala Asp Arg Pro Val Ser Leu Thr Asn 
145                 150                 155                 160 


Arg Pro Glu Glu Ala Met Met Val Thr Lys Phe Tyr Phe Gln Lys Glu 
                165                 170                 175     


