                         SEQUENCE LISTING

<110>  CuRNA, Inc.
 
<120>  TREATMENT OF INSULIN RECEPTOR SUBSTRATE 2 (IRS2) RELATED DISEASES
        BY INHIBITION OF NATURAL ANTISENSE TRANSCRIPT TO IRS2 AND 
       TRANSCRIPTION FACTOR E3 (TFE3)

<130>  IRS2

<150>  US61/291419
<151>  2009-12-31

<160>  11    

<170>  PatentIn version 3.5

<210>  1
<211>  7014
<212>  DNA
<213>  Homo sapiens

<300>
<308>  NM_003749
<309>  2010-12-25
<313>  (1)..(7014)

<400>  1
cggggaccgc gacgagcccg ggtcgccgtt ggcagcagca gcagcaacac cagcagcagc       60

agcagccccg gcggcggcgc ggaccccgag cgcccgggcg caccccggct tcccggagcg      120

cgacgcggcg gcagcagccc cggtgcggcc gcgcgcgcct taggctcggc cccgcggctc      180

ggggaccccg actcccggcc cagcgagcgc gtcccccggc gccgcccgag agcccgagga      240

ggcagcggcc gcaggcagcc ggggaggggg gcggccaccg cccgcgccgg gcatcctcag      300

gagccccaga gcgcggaggg cgcggcgccg ccgagcggtg ctggcccccg cgggcctccc      360

cggaccttcc ccaccgcctg ggcccgaggg acgcgtgatc gggcgggcgg ccgggcgcaa      420

gggtgggagg gagccgcccc cgcccgcgcc ccctccgccc ctcgccccaa cccctgggcg      480

ccgggcccgg gccgcgcggc ctgaagcgcc cgcgatggcg agcccgccgc ggcacgggcc      540

gcccgggccg gcgagcggag acggccccaa cctcaacaac aacaacaaca acaacaacca      600

cagcgtgcgc aagtgcggct acctgcgcaa gcagaagcat ggccacaagc gcttcttcgt      660

gctgcgcgga cccggcgcgg gcggcgacga ggcgacggcg ggcggggggt cggcgccgca      720

accgccgcgg ctcgagtact acgagagcga gaaaaagtgg cggagcaagg caggcgcgcc      780

gaaacgggtg atcgctctcg actgctgcct gaacatcaac aagcgcgccg acgccaagca      840

caagtacctg atcgccctct acaccaagga cgagtacttc gccgtggccg ccgagaacga      900

gcaggagcag gagggctggt accgcgcgct caccgacctg gtcagcgagg gccgcgcggc      960

cgccggagac gcgccccccg ccgccgcgcc cgccgcgtcc tgcagcgcct ccctgcccgg     1020

cgccctgggc ggctctgccg gcgccgccgg ggccgaggac agctacgggc tggtggctcc     1080

cgccacggcc gcctaccgtg aggtgtggca ggtgaacctg aagcccaagg gtctgggcca     1140

gagcaagaac ctgacggggg tgtaccgtct gtgcctgtct gcgcgcacca tcggcttcgt     1200

gaagctcaac tgcgagcagc cgtcggtgac gctgcagctc atgaacatcc gccgctgcgg     1260

ccactcggac agcttcttct tcatcgaggt gggccgctcg gccgtcacag gccccggcga     1320

gctgtggatg caggcggacg actcggtggt ggcgcagaac atccacgaga ccatcctgga     1380

ggccatgaag gcgctcaagg agctcttcga gttccggccg cgcagtaaga gccaatcgtc     1440

ggggtcgtcg gccacgcacc ccatcagcgt ccccggcgcg cgccgccacc accacctggt     1500

caacctgccc cccagccaga cgggcctggt gcgccgctcg cgcaccgaca gcctggccgc     1560

caccccgccg gcggccaagt gcagctcgtg ccgggtgcgc accgccagcg agggcgacgg     1620

cggcgcggcg gcgggagcgg cggccgcggg cgccaggccg gtgtcggtgg ctgggagccc     1680

cctgagcccc gggccggtgc gcgcgcccct gagccgctcg cacaccctga gcggcggctg     1740

cggcggccgc gggagcaagg tggcgctgct gccggcaggg ggcgcgctgc aacacagccg     1800

ctccatgtcc atgcccgtgg cgcactcgcc gcccgccgcc accagccccg gctccctgtc     1860

gtccagcagc ggccacggct cgggctccta cccgccgccg cccggcccgc acccgcctct     1920

gccgcatccg ctgcaccacg gccccggcca gcggccctcc agcggcagcg cctccgcctc     1980

gggctccccc agcgaccccg gcttcatgtc cctggacgag tacggctcca gcccaggcga     2040

cctgcgcgcc ttctgcagcc accgaagcaa cacgcccgag tccatcgcgg agacgccccc     2100

ggcccgagac ggcggcggcg gcggtgagtt ctacgggtac atgaccatgg acaggcccct     2160

gagccactgt ggccgctcct accgccgggt ctcgggggac gcggcccagg acctggaccg     2220

agggctgcgc aagaggacct actccctgac cacgccagcc cggcagcggc cggtgcccca     2280

gccctcctct gcctcgctgg atgaatacac cctgatgcgg gccaccttct cgggcagcgc     2340

gggccgcctc tgcccgtcct gccccgcgtc ctctcccaag gtggcctacc acccctaccc     2400

agaggactac ggagacatcg agatcggctc ccacaggagc tccagcagca acctgggggc     2460

agacgacggc tacatgccca tgacgcccgg cgcggccctc gcgggcagtg ggagcggcag     2520

ctgcaggagc gacgactaca tgcccatgag ccccgccagc gtgtccgccc ccaagcagat     2580

cttgcagccc agggccgccg ccgccgccgc cgccgccgtg ccttctgcgg ggcctgcggg     2640

gccagcaccc acctctgcgg cgggcaggac attcccggcg agcgggggcg gctacaaggc     2700

cagctcgccc gccgagagct cccccgagga cagtgggtac atgcgcatgt ggtgcggttc     2760

caagctgtcc atggagcatg cagatggcaa gctgctgccc aacggggact acctcaacgt     2820

gtcccccagc gacgcggtca ccacgggcac cccgcccgac ttcttctccg cagccctgca     2880

ccccggcggg gagccgctca ggggcgttcc cggctgctgc tacagctcct tgccccgctc     2940

ctacaaggcc ccctacacct gtggcgggga cagcgaccag tacgtgctca tgagctcccc     3000

cgtggggcgc atcctggagg aggagcgtct ggagcctcag gccacgccag ggcccagcca     3060

ggcggccagc gccttcgggg ccggccccac gcagccccct caccctgtag tgccttcgcc     3120

cgtgcggcct agcggcggcc gcccggaggg cttcttgggc cagcgcggcc gggcggtgag     3180

gcccacgcgc ctgtccctgg aggggctgcc cagcctgccc agcatgcacg agtacccact     3240

gccaccggag cccaagagcc ccggcgagta catcaacatc gactttggcg agcccggggc     3300

ccgcctgtcg ccgcccgcgc ctcccctgct ggcgtcggcg gcctcgtcct cctcgctctt     3360

gtccgccagc agcccggcct cgtcgctggg ctcaggcacc ccgggcacca gcagcgacag     3420

ccggcagcgg tctccgctct ccgactacat gaacctcgac ttcagctccc ccaagtctcc     3480

taagccgggc gccccgagcg gccaccccgt gggctccttg gacggcctcc tgtcccccga     3540

ggcctcctcc ccgtatccgc cgttgccccc gcgtccgtcc gcgtccccgt cgtcgtctct     3600

gcagccgccg ccaccgccgc cggccccggg ggagctgtac cgcctgcccc ccgcctcggc     3660

cgttgccacc gcccagggcc cgggcgccgc ctcatcgttg tcctcggaca ccggggacaa     3720

tggtgactac accgagatgg cttttggtgt ggccgccacc ccgccgcaac ctatcgcggc     3780

ccccccgaag ccagaagctg cccgcgtggc cagcccgacg tcgggcgtga agaggctgag     3840

cctcatggag caggtgtcgg gagtcgaggc cttcctgcag gccagccagc ccccggaccc     3900

ccaccgcggc gccaaggtca tccgcgcaga cccgcagggg ggccgccgcc gccacagttc     3960

cgagaccttc tcctccacca cgacggtcac ccccgtgtcc ccgtccttcg cccacaaccc     4020

caagcgccac aactcggcct ccgtggaaaa tgtctctctc aggaaaagca gcgagggcgg     4080

cgtgggtgtc ggccctggag ggggcgacga gccgcccacc tccccacgac agttgcagcc     4140

ggcgccccct ttggcaccgc agggccggcc gtggaccccg ggtcagcccg ggggcttggt     4200

cggttgtcct gggagcggtg gatcgcccat gcgcagagag acctctgccg gcttccagaa     4260

tggtctcaac tacatcgcca tcgacgtgag ggaggagccc gggctgccac cccagccgca     4320

gccgccgccg ccgccgcttc ctcagccggg agacaagagc tcctggggcc ggacccgaag     4380

cctcgggggt ctcatcagcg ctgtgggcgt cggcagcacc ggcggcgggt gcggggggcc     4440

gggtcccggt gccctgcccc ctgccaacac ctacgccagc attgacttct tgtcccacca     4500

cttgaaggag gccaccatcg tgaaagagtg aagatctgtc tggctttatc accaggatgt     4560

cacatgtcag agagtatcat taaaagaaga cgctcagcac tgtttcagcc cgaagctgct     4620

tgcagttttc ttttggatct gagcaatgac tgtgtttgga aacatctgtg gactctgtta     4680

gatgaggcac caacaaggca aggtcacctg cctctttccc ttgttcccgg atggggcatt     4740

catcattgtg ctgtttgcgt tttgttttgt tttgttttaa caaaattagc tgaagaagtt     4800

attctcaaga aaattggatg ttttcattgg ccttcttaaa ttgtggccag tgtcttttaa     4860

tttcttcttc ttttcctttt ggcaaagcag atataaccct cagcatgcta ggagagtgca     4920

cccgtaccta tggaagtggt aaaatctggt atttactggc ttacactcaa aacgaccaca     4980

gtcctacctc agttcaaggt aaagccggat ttccgtggcg ggggtcccac aggacctcct     5040

gtagtagccc ctgcgctgtg tgtctggagc gcggtcctcg gccttattga aatggtccaa     5100

gtagacagct gcttgttgga ttccagtgca ggtacctgcg atgtttacgt ccacaccgag     5160

cccagtgtgg gactgacatt tctcaatgga agtgaaattt gggattggac tttgaagacg     5220

gattactaaa taataattat tatatgtaac tgaagcaacc tacttttgaa aatcaactgt     5280

attgggtagt gggaggtggg agggaagggc tttgggaagg ggatgaatat ctctttttac     5340

ctttaacaga cttgtttaat cttctcgatg tagatgttta tgtaggtact tcacattgca     5400

aacgcctttt attctattta caagctcaga tgtctctgct ctcctgaatc ttgggcatgc     5460

ctttctgtaa ccaaaaatcc ctgtaggcgt gctagcaatt ccagggtggt ccgggtttgg     5520

cagatttgat ttttaaaaaa cgtattatct ttaataaaat gttattatgt caaccagtga     5580

ggctgccctg aacaaaaaaa acaaaaagaa aaaaaaaaaa ggaaagaaag aaactgataa     5640

aaagaggcat tccagcccct atgttattga tggaaaaaga aaaagaagaa aagcaatctc     5700

gcagtacatg ttacttgtcg aaaaaattcc ggacaagact acccttgttt tatgttttca     5760

gtattctgaa aataccagtg tgtggcagtt ctcgcagatg ttacctaaaa ctgctgaact     5820

tgaccggcag aatgttctgc cgttttctgc tccctcgaca cttgattgga gggctgtcga     5880

cctctcctcc cgtgggggct tccccagtgc ctatcttctc tgatagtcat ggagaggtta     5940

cactaattca ttggagatgt aagttgttgg ttttgttttg ttttgttttt agaaaaatat     6000

atataaatat ataatagata tctatcgcta tagaataatg cattaataaa atgaggcttt     6060

tttagaggaa gaccaaaaaa ttcaatgtct taaaaatata tttaatggca atgcaaaagt     6120

cttcctgctt ccgtgctgaa ctttagaaca gaggattgta ttgcaagaca aagttgaatg     6180

taaagtgatc tccctgaaca tttttaaggt tttacttttc tgaaattata catcacagca     6240

gtgcataggc catataatgt tagctggaag gtcaatttca gtgtatgata tactttatta     6300

agatgtataa aaatcctgaa gtttttattt agttttggga ataggcatca atgggtggta     6360

tttgctttgt aactcccccc aggtacgata gggactgaat atggaccctg ctgaaagcag     6420

tgtattgacg catatttaac tcgccctcta tccgtagagt agtcatgaca ctatacagat     6480

ggttcgtgtt catactgcag cttaaaacaa gcaaaataca cagatgataa tatgctaaat     6540

tttcctctat cctgtacatt tcacaaaaag gcatatgcaa tatttacatt tttaatttag     6600

tttacagaat ggaaccaaaa tgtataaatg ttatgtttgc taaaacttca caatgtatat     6660

tgggtctttg tacattttgc ctgacttacc ttaaatttaa aatatttttt gctatataaa     6720

ctttaacagt tattaaacag tgttttcttt ttgggtacgt attgtttctg gatatcaaga     6780

tgttaaatat atttcttgct attgtgatat gacaagagac ttaacttatc ttgctctgtc     6840

ttccactgta cacgctgtat ataggggtca atgtgatgct gctggagacg agaataaact     6900

ggactagaat agtgcattgt atttagtctg tattgatcat ggatgccctc cttaatagcc     6960

atatgcaata aaataaagta cattatttat gaaatgaaaa aaaaaaaaaa aaaa           7014


<210>  2
<211>  497
<212>  DNA
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (232)..(232)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (407)..(407)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (482)..(482)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (484)..(484)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (487)..(487)
<223>  n is a, c, g, or t

<400>  2
gccaaagtta aaagcgcatc aaacacgcct agcttttatt attttaatca caaacctata       60

gacccctcag tataccctcc atggggcctg gccccagcaa tccaaagctg acaaccttgg      120

gtgtaggtat gaggggtggg aatggagggg ggagtgtctc ttgataactc tgaaatgggg      180

tgattcctcc aaatgaagaa ctgggtgggg aacagaggtt ggggtggcct anattctcag      240

tatgcggagc aataaaaaaa tcagataaac aaatgagggg gtacaatatg cttttacaac      300

cctcctccaa gcttctgcct tgctggggga aggcttccag tttttcctgg gctggggagg      360

tcccaggata gccccttcct tcatcctctt gccctgcact gggcggntcc tttggggaag      420

gtgcagggcc tcatctgact cctcctcctt gcctgattac aggggtgggg cctgatcaca      480

tntnctnttc ccccagg                                                     497


<210>  3
<211>  633
<212>  DNA
<213>  Homo sapiens

<400>  3
tttttttttt ttttttctga aaactgcaaa aggtggcaaa aggtgagaat gggaggagac       60

tcatctgtga ctaactcccc catcagcctc acgggtgggt gacttggagc tccccaaccc      120

aatgggactt ccttctttcg cctacactgg ccaccaccat ggagggcagg gaggccaaga      180

gcggcaagca gccctttgag ccggtggggg ctgtggttgg caggaaagga gggggctttc      240

ctgaacaggc tagggatgcc tatagaaaga atgtgatcaa tacccttaac gcagcctttg      300

gggctgccta caaaaaggag ccaagaaacc tgacaatggg gaagtttctg gaatactacc      360

atttacaaca aagactgagc acagaatgaa gtaccaggag agcttggagg caaggccgcc      420

aagagctcag ggcaagctga catctaggaa tcgggatagc agcagaatca aagctactat      480

ttttcagaga agaaaactta caaacactac ctcatctgat gcaccccagg ttcacgcagg      540

ggtgaagggg tgaaacatct gagtggtccc agctgtgaat gggaccagta ctgtgaatgt      600

tccagcaagg atatccactg ccgccctcgt gcc                                   633


<210>  4
<211>  54
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<400>  4
rarurarcrc rurarcrarc rcrcrararg rgrururgru rcrargrcru ruru             54


<210>  5
<211>  54
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<400>  5
rcrargrcra rargrgrcra rgrarargrc rururgrgra rgrgrargrg rgru             54


<210>  6
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<400>  6
gtctcctccc attctcacct                                                   20


<210>  7
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<400>  7
cctcctttcc tgccaaccac a                                                 21


<210>  8
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<400>  8
gcatccctag cctgttcag                                                    19


<210>  9
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<400>  9
tctgctgcta tcccgattcc t                                                 21


<210>  10
<211>  48
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Reverse complement of the antisense oligonucleotide SEQ ID NO: 4

<400>  10
rargrcrurg rarcrararc rcrururgrg rgrurgrura rgrgruat                    48


<210>  11
<211>  48
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Reverse complement of the antisense oligonucleotide SEQ ID NO: 5

<400>  11
rcrcrurcrc rurcrcrara rgrcrururc rurgrcrcru rurgrctg                    48


