                         SEQUENCE LISTING

<110>  Flach, Carl-Fredrik
       Holmgren, Jan
 
<120>  New antigens for use in a vaccine against H. pylori infection

<130>  HpaA

<150>  SE 0901612-2
<151>  2009-12-28

<160>  22    

<170>  PatentIn version 3.5

<210>  1
<211>  260
<212>  PRT
<213>  Helicobacter pylori 26695

<400>  1

Met Lys Ala Asn Asn His Phe Lys Asp Phe Ala Trp Lys Lys Cys Leu 
1               5                   10                  15      


Leu Gly Ala Ser Val Val Ala Leu Leu Val Gly Cys Ser Pro His Ile 
            20                  25                  30          


Ile Glu Thr Asn Glu Val Ala Leu Lys Leu Asn Tyr His Pro Ala Ser 
        35                  40                  45              


Glu Lys Val Gln Ala Leu Asp Glu Lys Ile Leu Leu Leu Arg Pro Ala 
    50                  55                  60                  


Phe Gln Tyr Ser Asp Asn Ile Ala Lys Glu Tyr Glu Asn Lys Phe Lys 
65                  70                  75                  80  


Asn Gln Thr Ala Leu Lys Val Glu Gln Ile Leu Gln Asn Gln Gly Tyr 
                85                  90                  95      


Lys Val Ile Ser Val Asp Ser Ser Asp Lys Asp Asp Leu Ser Phe Ser 
            100                 105                 110         


Gln Lys Lys Glu Gly Tyr Leu Ala Val Ala Met Asn Gly Glu Ile Val 
        115                 120                 125             


Leu Arg Pro Asp Pro Lys Arg Thr Ile Gln Lys Lys Ser Glu Pro Gly 
    130                 135                 140                 


Leu Leu Phe Ser Thr Gly Leu Asp Lys Met Glu Gly Val Leu Ile Pro 
145                 150                 155                 160 


Ala Gly Phe Val Lys Val Thr Ile Leu Glu Pro Met Ser Gly Glu Ser 
                165                 170                 175     


Leu Asp Ser Phe Thr Met Asp Leu Ser Glu Leu Asp Ile Gln Glu Lys 
            180                 185                 190         


Phe Leu Lys Thr Thr His Ser Ser His Ser Gly Gly Leu Val Ser Thr 
        195                 200                 205             


Met Val Lys Gly Thr Asp Asn Ser Asn Asp Ala Ile Lys Ser Ala Leu 
    210                 215                 220                 


Asn Lys Ile Phe Ala Asn Ile Met Gln Glu Ile Asp Lys Lys Leu Thr 
225                 230                 235                 240 


Gln Lys Asn Leu Glu Ser Tyr Gln Lys Asp Ala Lys Glu Leu Lys Gly 
                245                 250                 255     


Lys Arg Asn Arg 
            260 


<210>  2
<211>  260
<212>  PRT
<213>  Helicobacter pylori P12

<400>  2

Met Lys Ala Asn Asn His Phe Lys Asp Phe Ala Trp Lys Lys Cys Leu 
1               5                   10                  15      


Leu Gly Ala Ser Val Val Ala Leu Leu Val Gly Cys Ser Pro His Ile 
            20                  25                  30          


Ile Glu Thr Asn Glu Val Ala Leu Lys Leu Asn Tyr His Pro Ala Ser 
        35                  40                  45              


Glu Lys Val Gln Ala Leu Asp Glu Lys Ile Leu Leu Leu Arg Pro Ala 
    50                  55                  60                  


Phe Gln Tyr Ser Asp Asn Ile Ala Lys Glu Tyr Glu Asn Lys Phe Lys 
65                  70                  75                  80  


Asn Gln Thr Thr Leu Lys Val Glu Gln Ile Leu Gln Asn Gln Gly Tyr 
                85                  90                  95      


Lys Val Ile Ser Val Asp Ser Ser Asp Lys Asp Asp Leu Ser Phe Ser 
            100                 105                 110         


Gln Lys Lys Glu Gly Tyr Leu Ala Val Ala Met Asn Gly Glu Ile Val 
        115                 120                 125             


Leu Arg Pro Asp Pro Lys Arg Thr Ile Gln Lys Lys Ser Glu Pro Gly 
    130                 135                 140                 


Leu Leu Phe Ser Thr Gly Leu Asp Lys Met Glu Gly Val Leu Ile Pro 
145                 150                 155                 160 


Ala Gly Phe Ile Lys Val Thr Ile Leu Glu Pro Met Ser Gly Glu Ser 
                165                 170                 175     


Leu Asp Ser Phe Thr Met Asp Leu Ser Glu Leu Asp Ile Gln Glu Lys 
            180                 185                 190         


Phe Leu Lys Thr Thr His Ser Ser His Ser Gly Gly Leu Val Ser Thr 
        195                 200                 205             


Met Val Lys Gly Thr Asp Asn Ser Asn Asp Ala Ile Lys Ser Ala Leu 
    210                 215                 220                 


Asn Lys Ile Phe Ala Asn Ile Met Gln Glu Ile Asp Lys Lys Leu Thr 
225                 230                 235                 240 


Gln Lys Asn Leu Glu Ser Tyr Gln Lys Asp Ala Lys Glu Leu Lys Gly 
                245                 250                 255     


Lys Arg Asn Arg 
            260 


<210>  3
<211>  260
<212>  PRT
<213>  Helicobacter pylori NCTC 11637

<400>  3

Met Arg Ala Asn Asn His Phe Lys Asp Phe Ala Trp Lys Lys Cys Leu 
1               5                   10                  15      


Leu Gly Ala Ser Val Val Ala Leu Leu Val Gly Cys Ser Pro His Ile 
            20                  25                  30          


Ile Glu Thr Asn Glu Val Ala Leu Lys Leu Asn Tyr His Pro Ala Ser 
        35                  40                  45              


Glu Lys Val Gln Ala Leu Asp Glu Lys Ile Leu Leu Leu Arg Pro Ala 
    50                  55                  60                  


Phe Gln Tyr Ser Asp Asn Ile Ala Lys Glu Tyr Glu Asn Lys Phe Lys 
65                  70                  75                  80  


Asn Gln Thr Ala Leu Lys Val Glu Gln Ile Leu Gln Asn Gln Gly Tyr 
                85                  90                  95      


Lys Val Ile Ser Val Asp Ser Ser Asp Lys Asp Asp Phe Ser Phe Ala 
            100                 105                 110         


Gln Lys Lys Glu Gly Tyr Leu Ala Val Ala Met Asn Gly Glu Ile Val 
        115                 120                 125             


Leu Arg Pro Asp Pro Lys Arg Thr Ile Gln Lys Lys Ser Glu Pro Gly 
    130                 135                 140                 


Leu Leu Phe Ser Thr Gly Leu Asp Lys Met Glu Gly Val Leu Ile Pro 
145                 150                 155                 160 


Ala Gly Phe Ile Lys Val Thr Ile Leu Glu Pro Met Ser Gly Glu Ser 
                165                 170                 175     


Leu Asp Ser Phe Thr Met Asp Leu Ser Glu Leu Asp Ile Gln Glu Lys 
            180                 185                 190         


Phe Leu Lys Thr Thr His Ser Ser His Ser Gly Gly Leu Val Ser Thr 
        195                 200                 205             


Met Val Lys Gly Thr Asp Asn Ser Asn Asp Ala Ile Lys Ser Ala Leu 
    210                 215                 220                 


Asn Lys Ile Phe Ala Asn Ile Met Gln Glu Ile Asp Lys Lys Leu Thr 
225                 230                 235                 240 


Gln Lys Asn Leu Glu Ser Tyr Gln Lys Asp Ala Lys Glu Leu Lys Gly 
                245                 250                 255     


Lys Arg Asn Arg 
            260 


<210>  4
<211>  260
<212>  PRT
<213>  Helicobacter pylori G27

<400>  4

Met Lys Ala Asn Asn His Phe Lys Asp Phe Ala Trp Lys Lys Cys Leu 
1               5                   10                  15      


Leu Gly Ala Ser Val Ala Ala Leu Leu Val Gly Cys Ser Pro His Ile 
            20                  25                  30          


Ile Glu Thr Asn Glu Val Ala Leu Lys Leu Asn Tyr His Pro Ala Ser 
        35                  40                  45              


Glu Lys Val Gln Ala Leu Asp Glu Lys Ile Leu Leu Leu Arg Pro Ala 
    50                  55                  60                  


Phe Gln Tyr Ser Asp Asn Ile Ala Lys Glu Tyr Glu Asn Lys Phe Lys 
65                  70                  75                  80  


Asn Gln Thr Ala Leu Lys Val Glu Gln Ile Leu Gln Asn Gln Gly Tyr 
                85                  90                  95      


Lys Val Ile Ser Val Asp Ser Ser Asp Lys Asp Asp Leu Ser Phe Ser 
            100                 105                 110         


Gln Lys Lys Glu Gly Tyr Leu Ala Val Ala Met Asn Gly Glu Ile Val 
        115                 120                 125             


Leu Arg Pro Asp Pro Lys Arg Thr Ile Gln Lys Lys Ser Glu Pro Gly 
    130                 135                 140                 


Leu Leu Phe Ser Thr Gly Leu Asp Lys Met Glu Gly Val Leu Ile Pro 
145                 150                 155                 160 


Ala Gly Phe Ile Lys Val Thr Ile Leu Glu Pro Met Ser Gly Glu Ser 
                165                 170                 175     


Leu Asp Ser Phe Thr Met Asp Leu Ser Glu Leu Asp Ile Gln Glu Lys 
            180                 185                 190         


Phe Leu Lys Thr Thr His Ser Ser His Ser Gly Gly Leu Val Ser Thr 
        195                 200                 205             


Met Val Lys Gly Thr Asp Asn Ser Asn Asp Ala Ile Lys Ser Ala Leu 
    210                 215                 220                 


Asn Lys Ile Phe Ala Asn Ile Met Gln Glu Ile Asp Lys Lys Leu Thr 
225                 230                 235                 240 


Gln Lys Asn Leu Glu Ser Tyr Gln Lys Asp Ala Lys Glu Leu Gln Asn 
                245                 250                 255     


Lys Arg Asn Arg 
            260 


<210>  5
<211>  260
<212>  PRT
<213>  Helicobacter pylori 52

<400>  5

Met Lys Ala Asn Asn His Phe Lys Asp Phe Ala Trp Lys Lys Cys Leu 
1               5                   10                  15      


Leu Gly Ala Ser Val Val Ala Leu Leu Val Gly Cys Ser Pro His Ile 
            20                  25                  30          


Ile Glu Thr Asn Glu Val Thr Leu Lys Leu Asn Tyr His Pro Ala Ser 
        35                  40                  45              


Glu Lys Val Gln Ala Leu Asp Glu Lys Ile Leu Leu Leu Arg Pro Ala 
    50                  55                  60                  


Phe Gln Tyr Ser Asp Asn Ile Ala Lys Glu Tyr Glu Asn Lys Phe Lys 
65                  70                  75                  80  


Asn Gln Thr Ala Leu Lys Val Glu Gln Ile Leu Gln Asn Gln Gly Tyr 
                85                  90                  95      


Lys Val Ile Asn Val Asp Ser Ser Asp Lys Asp Asp Leu Ser Phe Ser 
            100                 105                 110         


Gln Lys Lys Glu Gly Tyr Leu Ala Val Ala Met Asn Gly Glu Ile Val 
        115                 120                 125             


Leu Arg Pro Asp Pro Lys Arg Thr Ile Gln Lys Lys Ser Glu Pro Gly 
    130                 135                 140                 


Leu Leu Phe Ser Thr Gly Leu Asp Lys Met Glu Gly Val Leu Ile Pro 
145                 150                 155                 160 


Ala Gly Phe Val Lys Val Thr Ile Leu Glu Pro Met Ser Gly Glu Ser 
                165                 170                 175     


Leu Asp Ser Phe Thr Met Asp Leu Ser Glu Leu Asp Ile Gln Glu Lys 
            180                 185                 190         


Phe Leu Lys Thr Thr His Ser Ser His Ser Gly Gly Leu Val Ser Thr 
        195                 200                 205             


Met Val Lys Gly Thr Asp Asn Ser Asn Asp Ala Ile Lys Ser Ala Leu 
    210                 215                 220                 


Asn Lys Ile Phe Ala Asn Ile Met Gln Glu Ile Asp Lys Lys Leu Thr 
225                 230                 235                 240 


Gln Lys Asn Leu Glu Ser Tyr Gln Lys Asp Ala Lys Glu Leu Lys Gly 
                245                 250                 255     


Lys Arg Asn Arg 
            260 


<210>  6
<211>  260
<212>  PRT
<213>  Helicobacter pylori B38

<400>  6

Met Lys Ala Asn Asn His Phe Lys Asp Phe Ala Trp Lys Lys Cys Leu 
1               5                   10                  15      


Leu Gly Ala Ser Val Ala Ala Leu Leu Val Gly Cys Ser Pro His Ile 
            20                  25                  30          


Ile Glu Thr Asn Glu Val Ala Leu Lys Leu Asn Tyr His Pro Ala Ser 
        35                  40                  45              


Glu Lys Val Gln Ala Leu Asp Glu Lys Ile Leu Leu Leu Arg Pro Ala 
    50                  55                  60                  


Phe Gln Tyr Ser Asp Asn Ile Ala Lys Glu Tyr Glu Asn Lys Phe Lys 
65                  70                  75                  80  


Asn Gln Thr Ala Leu Lys Val Glu Gln Ile Leu Gln Asn Gln Gly Tyr 
                85                  90                  95      


Lys Val Ile Asn Val Asp Ser Ser Asp Lys Asp Asp Phe Ser Phe Ala 
            100                 105                 110         


Gln Lys Lys Glu Gly Tyr Leu Ala Val Ala Met Asn Gly Glu Ile Val 
        115                 120                 125             


Leu Arg Pro Asp Pro Lys Arg Thr Ile Gln Lys Lys Ser Glu Pro Gly 
    130                 135                 140                 


Leu Leu Phe Ser Thr Gly Leu Asp Lys Met Glu Gly Val Leu Ile Pro 
145                 150                 155                 160 


Ala Gly Phe Val Lys Val Thr Ile Leu Glu Pro Met Ser Gly Glu Ser 
                165                 170                 175     


Leu Asp Ser Phe Thr Met Asp Leu Ser Glu Leu Asp Ile Gln Glu Lys 
            180                 185                 190         


Phe Leu Lys Thr Thr His Ser Ser His Ser Gly Gly Leu Val Ser Thr 
        195                 200                 205             


Met Val Lys Gly Thr Asp Asn Ser Asn Asp Ala Ile Lys Ser Ala Leu 
    210                 215                 220                 


Asn Lys Ile Phe Ala Asn Ile Met Gln Glu Ile Asp Lys Lys Leu Thr 
225                 230                 235                 240 


Gln Lys Asn Leu Glu Ser Tyr Gln Lys Asp Ala Lys Glu Leu Lys Gly 
                245                 250                 255     


Lys Arg Asn Arg 
            260 


<210>  7
<211>  260
<212>  PRT
<213>  Helicobacter pylori HPAG1

<400>  7

Met Lys Ala Asn Asn His Phe Lys Asp Phe Ala Trp Lys Lys Cys Leu 
1               5                   10                  15      


Leu Gly Ala Ser Val Val Ala Leu Leu Val Gly Cys Ser Pro His Ile 
            20                  25                  30          


Ile Glu Thr Asn Glu Val Ala Leu Lys Leu Asn Tyr His Pro Ala Ser 
        35                  40                  45              


Glu Lys Val Gln Ala Leu Asp Glu Lys Ile Leu Leu Leu Arg Pro Ala 
    50                  55                  60                  


Phe Gln Tyr Ser Asp Asn Ile Ala Lys Glu Tyr Glu Asn Lys Phe Lys 
65                  70                  75                  80  


Asn Gln Thr Thr Leu Lys Val Glu Gln Ile Leu Gln Asn Gln Gly Tyr 
                85                  90                  95      


Lys Val Ile Asn Val Asp Ser Ser Asp Lys Asp Asp Phe Ser Phe Ala 
            100                 105                 110         


Gln Lys Lys Glu Gly Tyr Leu Ala Val Ala Met Asn Gly Glu Ile Val 
        115                 120                 125             


Leu Arg Pro Asp Pro Lys Arg Thr Ile Gln Lys Lys Ser Glu Pro Gly 
    130                 135                 140                 


Leu Leu Phe Ser Thr Gly Leu Asp Lys Met Glu Gly Val Leu Ile Pro 
145                 150                 155                 160 


Ala Gly Phe Val Lys Val Thr Ile Leu Glu Pro Met Ser Gly Glu Ser 
                165                 170                 175     


Leu Asp Ser Phe Thr Met Asp Leu Ser Glu Leu Asp Ile Gln Glu Lys 
            180                 185                 190         


Phe Leu Lys Thr Thr His Ser Ser His Ser Gly Gly Leu Val Ser Thr 
        195                 200                 205             


Met Val Lys Gly Thr Asp Asn Ser Asn Asp Ala Ile Lys Ser Ala Leu 
    210                 215                 220                 


Asn Lys Ile Phe Ala Asn Ile Met Gln Glu Ile Asp Lys Lys Leu Thr 
225                 230                 235                 240 


Gln Lys Asn Leu Glu Ser Tyr Gln Lys Asp Ala Lys Glu Leu Lys Gly 
                245                 250                 255     


Lys Arg Asn Arg 
            260 


<210>  8
<211>  260
<212>  PRT
<213>  Helicobacter pylori Y06

<400>  8

Met Arg Ala Asn Asn His Phe Lys Asp Phe Ala Trp Lys Lys Cys Leu 
1               5                   10                  15      


Leu Gly Ala Ser Val Val Ala Leu Leu Val Gly Cys Ser Pro His Ile 
            20                  25                  30          


Ile Glu Thr Asn Glu Val Ala Leu Lys Leu Asn Tyr His Pro Ala Ser 
        35                  40                  45              


Glu Lys Val Gln Ala Leu Asp Glu Lys Ile Leu Leu Leu Arg Pro Ala 
    50                  55                  60                  


Phe Gln Tyr Ser Asp Asn Ile Ala Lys Glu Tyr Glu Asn Lys Phe Lys 
65                  70                  75                  80  


Asn Gln Thr Thr Leu Lys Val Glu Glu Ile Leu Gln Asn Gln Gly Tyr 
                85                  90                  95      


Lys Val Ile Ser Val Asp Ser Ser Asp Lys Asp Asp Leu Ser Phe Ser 
            100                 105                 110         


Gln Lys Lys Glu Gly Tyr Leu Ala Val Ala Met Asn Gly Glu Ile Val 
        115                 120                 125             


Leu Arg Pro Asp Pro Lys Arg Thr Ile Gln Lys Lys Ser Glu Pro Gly 
    130                 135                 140                 


Leu Leu Phe Ser Thr Gly Leu Asp Lys Met Glu Gly Val Leu Ile Pro 
145                 150                 155                 160 


Ala Gly Phe Val Lys Val Thr Ile Leu Glu Pro Met Ser Gly Glu Ser 
                165                 170                 175     


Leu Asp Ser Phe Thr Met Asp Leu Ser Glu Leu Asp Ile Gln Glu Lys 
            180                 185                 190         


Phe Leu Lys Thr Thr His Ser Ser His Ser Gly Gly Leu Val Ser Thr 
        195                 200                 205             


Met Val Lys Gly Thr Asp Asn Ser Asn Asp Ala Ile Lys Ser Ala Leu 
    210                 215                 220                 


Asn Lys Ile Phe Ala Asn Ile Met Gln Glu Ile Asp Lys Lys Leu Thr 
225                 230                 235                 240 


Gln Lys Asn Leu Glu Ser Tyr Gln Lys Asp Ala Lys Glu Leu Lys Asn 
                245                 250                 255     


Lys Arg Asn Arg 
            260 


<210>  9
<211>  260
<212>  PRT
<213>  Helicobacter pylori CH-CTX1

<400>  9

Met Lys Thr Asn Gly His Phe Lys Asp Phe Ala Trp Lys Lys Cys Leu 
1               5                   10                  15      


Leu Gly Ala Ser Val Val Ala Leu Leu Val Gly Cys Ser Pro His Ile 
            20                  25                  30          


Ile Glu Thr Asn Glu Val Ala Leu Lys Leu Asn Tyr His Pro Ala Ser 
        35                  40                  45              


Glu Lys Val Gln Ala Leu Asp Glu Lys Ile Leu Leu Leu Arg Pro Ala 
    50                  55                  60                  


Phe Gln Tyr Ser Asp Asn Ile Ala Lys Glu Tyr Glu Asn Lys Phe Lys 
65                  70                  75                  80  


Asn Gln Thr Ala Leu Lys Val Glu Gln Ile Leu Gln Asn Gln Gly Tyr 
                85                  90                  95      


Lys Val Ile Asn Val Asp Ser Ser Asp Lys Asp Asp Phe Ser Phe Ala 
            100                 105                 110         


Gln Lys Lys Glu Gly Tyr Leu Ala Val Ala Met Asn Gly Glu Ile Val 
        115                 120                 125             


Leu Arg Pro Asp Pro Lys Arg Thr Ile Gln Lys Lys Ser Glu Pro Gly 
    130                 135                 140                 


Leu Leu Phe Ser Thr Gly Leu Asp Lys Met Glu Gly Val Leu Ile Pro 
145                 150                 155                 160 


Ala Gly Phe Ile Lys Val Thr Ile Leu Glu Pro Met Ser Gly Glu Ser 
                165                 170                 175     


Leu Asp Ser Phe Thr Met Asp Leu Ser Glu Leu Asp Ile Gln Glu Lys 
            180                 185                 190         


Phe Leu Lys Thr Thr His Ser Ser His Ser Gly Gly Leu Val Ser Thr 
        195                 200                 205             


Met Val Lys Gly Thr Asp Asn Ser Asn Asp Ala Ile Lys Ser Ala Leu 
    210                 215                 220                 


Asn Lys Ile Phe Ala Asn Ile Met Gln Glu Ile Asp Lys Lys Leu Thr 
225                 230                 235                 240 


Gln Lys Asn Leu Glu Ser Tyr Gln Lys Asp Ala Lys Glu Leu Lys Asn 
                245                 250                 255     


Lys Arg Asn Arg 
            260 


<210>  10
<211>  260
<212>  PRT
<213>  Helicobacter pylori CCUG 17874

<400>  10

Met Lys Thr Asn Gly His Phe Lys Asp Phe Ala Trp Lys Lys Cys Leu 
1               5                   10                  15      


Leu Gly Ala Ser Val Gly Ala Leu Leu Val Gly Cys Ser Pro His Ile 
            20                  25                  30          


Ile Glu Thr Asn Glu Val Ala Leu Lys Leu Asn Tyr His Pro Ala Ser 
        35                  40                  45              


Glu Lys Val Gln Ala Leu Asp Glu Lys Ile Leu Leu Leu Arg Pro Ala 
    50                  55                  60                  


Phe Gln Tyr Ser Asp Asn Ile Ala Lys Glu Tyr Glu Asn Lys Phe Lys 
65                  70                  75                  80  


Asn Gln Thr Val Leu Lys Val Glu Gln Ile Leu Gln Asn Gln Gly Tyr 
                85                  90                  95      


Lys Val Ile Asn Val Asp Ser Ser Asp Lys Asp Asp Phe Ser Phe Ala 
            100                 105                 110         


Gln Lys Lys Glu Gly Tyr Leu Ala Val Ala Met Asn Gly Glu Ile Val 
        115                 120                 125             


Leu Arg Pro Asp Pro Lys Arg Thr Ile Gln Lys Lys Ser Glu Pro Gly 
    130                 135                 140                 


Leu Leu Phe Ser Thr Gly Leu Asp Lys Met Glu Gly Val Leu Ile Pro 
145                 150                 155                 160 


Ala Gly Phe Val Lys Val Thr Ile Leu Glu Pro Met Ser Gly Glu Ser 
                165                 170                 175     


Leu Asp Ser Phe Thr Met Asp Leu Ser Glu Leu Asp Ile Gln Glu Lys 
            180                 185                 190         


Phe Leu Lys Thr Thr His Ser Ser His Ser Gly Gly Leu Val Ser Thr 
        195                 200                 205             


Met Val Lys Gly Thr Asp Asn Ser Asn Asp Ala Ile Lys Ser Ala Leu 
    210                 215                 220                 


Asn Lys Ile Phe Gly Ser Ile Met Gln Glu Ile Asp Lys Lys Leu Thr 
225                 230                 235                 240 


Gln Lys Asn Leu Glu Ser Tyr Gln Lys Asp Ala Lys Glu Leu Lys Gly 
                245                 250                 255     


Lys Arg Asn Arg 
            260 


<210>  11
<211>  260
<212>  PRT
<213>  Helicobacter pylori MEL-HP27

<400>  11

Met Lys Ala Asn Asn His Phe Lys Asp Phe Ala Trp Lys Lys Cys Leu 
1               5                   10                  15      


Leu Gly Ala Ser Val Val Ala Leu Leu Val Gly Cys Ser Pro His Ile 
            20                  25                  30          


Ile Glu Thr Asn Glu Val Ala Leu Lys Leu Asn Tyr His Pro Ala Ser 
        35                  40                  45              


Glu Lys Val Gln Ala Leu Asp Glu Lys Ile Leu Leu Leu Lys Pro Ala 
    50                  55                  60                  


Phe Gln Tyr Ser Asp Asn Ile Ala Lys Glu Tyr Glu Asn Lys Phe Lys 
65                  70                  75                  80  


Asn Gln Thr Ala Leu Lys Val Glu Gln Ile Leu Gln Asn Gln Gly Tyr 
                85                  90                  95      


Lys Val Ile Asn Val Asp Ser Ser Asp Lys Asp Asp Leu Ser Phe Ala 
            100                 105                 110         


Gln Lys Lys Glu Gly Tyr Leu Ala Val Ala Met Ser Gly Glu Ile Val 
        115                 120                 125             


Leu Arg Pro Asp Pro Lys Arg Thr Thr Gln Lys Lys Ser Glu Pro Gly 
    130                 135                 140                 


Leu Leu Phe Ser Thr Gly Leu Asp Lys Met Glu Gly Val Leu Ile Pro 
145                 150                 155                 160 


Ala Gly Phe Ile Lys Val Thr Ile Leu Glu Pro Met Ser Gly Glu Ser 
                165                 170                 175     


Leu Asp Ser Phe Thr Met Asp Leu Ser Glu Leu Asp Ile Gln Glu Lys 
            180                 185                 190         


Phe Leu Lys Thr Thr His Ser Ser His Ser Gly Gly Leu Val Ser Thr 
        195                 200                 205             


Met Val Lys Gly Thr Asp Asn Ser Asn Asp Ala Ile Lys Ser Ala Leu 
    210                 215                 220                 


Asn Lys Ile Phe Ala Asn Ile Met Gln Glu Ile Asp Lys Lys Leu Thr 
225                 230                 235                 240 


Gln Lys Asn Leu Glu Ser Tyr Gln Lys Asp Ala Lys Glu Leu Lys Asn 
                245                 250                 255     


Lys Arg Asn Arg 
            260 


<210>  12
<211>  260
<212>  PRT
<213>  Helicobacter pylori 51

<400>  12

Met Lys Ala Asn Asn His Phe Lys Asp Phe Ala Trp Lys Lys Cys Leu 
1               5                   10                  15      


Leu Gly Ala Ser Val Val Ala Leu Leu Val Gly Cys Ser Pro His Ile 
            20                  25                  30          


Ile Glu Thr Asn Glu Val Ala Leu Lys Leu Asn Tyr His Pro Ala Ser 
        35                  40                  45              


Glu Lys Val Gln Ala Leu Asp Glu Lys Ile Leu Leu Leu Lys Pro Ala 
    50                  55                  60                  


Phe Gln Tyr Ser Asp Asn Ile Ala Lys Glu Tyr Glu Asn Lys Phe Lys 
65                  70                  75                  80  


Asn Gln Thr Ala Leu Lys Val Glu Gln Ile Leu Gln Asn Gln Gly Tyr 
                85                  90                  95      


Lys Val Ile Asn Val Asp Ser Ser Asp Lys Asp Asp Phe Ser Phe Ala 
            100                 105                 110         


Gln Lys Lys Glu Gly Tyr Leu Ala Val Ala Met Asn Gly Glu Ile Val 
        115                 120                 125             


Leu Arg Ser Asp Pro Lys Arg Thr Ile Gln Lys Lys Ser Glu Pro Gly 
    130                 135                 140                 


Leu Leu Phe Ser Thr Gly Leu Asp Lys Met Glu Gly Val Leu Ile Pro 
145                 150                 155                 160 


Ala Gly Phe Val Lys Val Thr Ile Leu Glu Pro Met Ser Gly Glu Ser 
                165                 170                 175     


Leu Asp Ser Phe Thr Met Asp Leu Ser Glu Leu Asp Ile Gln Glu Lys 
            180                 185                 190         


Phe Leu Lys Thr Thr His Ser Ser His Ser Gly Gly Leu Val Ser Thr 
        195                 200                 205             


Met Val Lys Gly Thr Asp Asn Ser Asn Asp Ala Ile Lys Ser Ala Leu 
    210                 215                 220                 


Asn Lys Ile Phe Ala Asn Ile Met Gln Glu Ile Asp Lys Lys Leu Thr 
225                 230                 235                 240 


Gln Lys Asn Leu Glu Ser Tyr Gln Lys Asp Ala Lys Glu Leu Lys Asn 
                245                 250                 255     


Lys Arg Asn Arg 
            260 


<210>  13
<211>  260
<212>  PRT
<213>  Helicobacter pylori J99

<400>  13

Met Lys Thr Asn Gly His Phe Lys Asp Phe Ala Trp Lys Lys Cys Phe 
1               5                   10                  15      


Leu Gly Ala Ser Val Val Ala Leu Leu Val Gly Cys Ser Pro His Ile 
            20                  25                  30          


Ile Glu Thr Asn Glu Val Ala Leu Lys Leu Asn Tyr His Pro Ala Ser 
        35                  40                  45              


Glu Lys Val Gln Ala Leu Asp Glu Lys Ile Leu Leu Leu Arg Pro Ala 
    50                  55                  60                  


Phe Gln Tyr Ser Asp Asn Ile Ala Lys Glu Tyr Glu Asn Lys Phe Lys 
65                  70                  75                  80  


Asn Gln Thr Thr Leu Lys Val Glu Glu Ile Leu Gln Asn Gln Gly Tyr 
                85                  90                  95      


Lys Val Ile Asn Val Asp Ser Ser Asp Lys Asp Asp Phe Ser Phe Ala 
            100                 105                 110         


Gln Lys Lys Glu Gly Tyr Leu Ala Val Ala Met Asn Gly Glu Ile Val 
        115                 120                 125             


Leu Arg Pro Asp Pro Lys Arg Thr Ile Gln Lys Lys Ser Glu Pro Gly 
    130                 135                 140                 


Leu Leu Phe Ser Thr Gly Leu Asp Lys Met Glu Gly Val Leu Ile Pro 
145                 150                 155                 160 


Ala Gly Phe Val Lys Val Thr Ile Leu Glu Pro Met Ser Gly Glu Ser 
                165                 170                 175     


Leu Asp Ser Phe Thr Met Asp Leu Ser Glu Leu Asp Ile Gln Glu Lys 
            180                 185                 190         


Phe Leu Lys Thr Thr His Ser Ser His Ser Gly Gly Leu Val Ser Thr 
        195                 200                 205             


Met Val Lys Gly Thr Asp Asn Ser Asn Asp Ala Ile Lys Ser Ala Leu 
    210                 215                 220                 


Asn Lys Ile Phe Ala Ser Ile Met Gln Glu Met Asp Lys Lys Leu Thr 
225                 230                 235                 240 


Gln Arg Asn Leu Glu Ser Tyr Gln Lys Asp Ala Lys Glu Leu Lys Asn 
                245                 250                 255     


Lys Arg Asn Arg 
            260 


<210>  14
<211>  260
<212>  PRT
<213>  Helicobacter pylori Shi470

<400>  14

Met Lys Ala Asn Asn His Phe Lys Asp Phe Ala Trp Lys Lys Cys Leu 
1               5                   10                  15      


Leu Gly Ala Ser Val Val Ala Leu Leu Val Gly Cys Ser Pro His Ile 
            20                  25                  30          


Ile Glu Thr Asn Glu Val Thr Leu Lys Leu Asn Tyr His Pro Ala Ser 
        35                  40                  45              


Glu Lys Val Gln Ala Leu Asp Glu Lys Ile Leu Leu Leu Arg Pro Ala 
    50                  55                  60                  


Phe Gln Tyr Ser Asp Asn Ile Ala Lys Glu Tyr Glu Asn Lys Phe Lys 
65                  70                  75                  80  


Asn Gln Thr Ala Ile Lys Val Glu Gln Ile Leu Gln Asn Gln Gly Tyr 
                85                  90                  95      


Lys Val Ile Asn Val Asp Ser Ser Asp Lys Asp Asp Phe Ser Phe Ala 
            100                 105                 110         


Gln Lys Lys Glu Gly Tyr Leu Ala Val Ala Met Asn Gly Glu Ile Val 
        115                 120                 125             


Leu Arg Pro Asp Pro Lys Arg Thr Ile Gln Lys Lys Ser Glu Pro Gly 
    130                 135                 140                 


Leu Leu Phe Ser Thr Gly Leu Asp Lys Met Glu Gly Val Leu Ile Ser 
145                 150                 155                 160 


Ala Gly Phe Ile Lys Val Thr Ile Leu Glu Pro Met Ser Gly Glu Ser 
                165                 170                 175     


Leu Asp Ser Phe Thr Met Asp Leu Ser Glu Leu Asp Ile Gln Glu Lys 
            180                 185                 190         


Phe Leu Lys Thr Thr His Ser Ser His Ser Gly Gly Leu Val Ser Thr 
        195                 200                 205             


Met Val Lys Gly Thr Asp Asn Ser Asn Asp Ala Ile Lys Ser Ala Leu 
    210                 215                 220                 


Asn Lys Ile Phe Thr Ser Ile Met Gln Glu Ile Asp Lys Lys Leu Thr 
225                 230                 235                 240 


Gln Lys Asn Leu Glu Ser Tyr Gln Lys Asp Ala Lys Glu Leu Lys Asn 
                245                 250                 255     


Lys Arg Asn Arg 
            260 


<210>  15
<211>  260
<212>  PRT
<213>  Helicobacter pylori 8826

<400>  15

Met Lys Thr Asn Gly His Phe Lys Asp Phe Ala Trp Lys Lys Cys Leu 
1               5                   10                  15      


Leu Gly Thr Ser Val Val Ala Leu Leu Val Gly Cys Ser Pro His Ile 
            20                  25                  30          


Ile Glu Thr Asn Glu Val Ala Leu Lys Leu Asn Tyr His Pro Ala Ser 
        35                  40                  45              


Glu Lys Val Gln Ala Leu Asp Glu Lys Ile Leu Leu Leu Lys Pro Ala 
    50                  55                  60                  


Phe Gln Tyr Ser Asp Asn Ile Ala Lys Glu Tyr Glu Asn Lys Phe Lys 
65                  70                  75                  80  


Asn Gln Thr Thr Leu Lys Val Glu Glu Ile Leu Gln Asn Gln Gly Tyr 
                85                  90                  95      


Lys Val Ile Asn Val Asp Ser Ser Asp Lys Asp Asp Phe Ser Phe Ala 
            100                 105                 110         


Gln Lys Lys Glu Gly Tyr Leu Ala Val Ala Met Ile Gly Glu Ile Val 
        115                 120                 125             


Leu Arg Pro Asp Pro Lys Arg Thr Ile Gln Lys Lys Ser Glu Pro Gly 
    130                 135                 140                 


Leu Leu Phe Ser Thr Gly Leu Asp Lys Met Glu Gly Val Leu Ile Pro 
145                 150                 155                 160 


Ala Gly Phe Val Lys Val Thr Ile Leu Glu Pro Met Ser Gly Glu Ser 
                165                 170                 175     


Leu Asp Ser Phe Thr Met Asp Leu Ser Glu Leu Asp Ile Gln Glu Lys 
            180                 185                 190         


Phe Leu Lys Thr Thr His Ser Ser His Ser Gly Gly Leu Val Ser Thr 
        195                 200                 205             


Met Val Lys Gly Thr Asp Asn Ser Asn Asp Ala Ile Lys Ser Ala Leu 
    210                 215                 220                 


Asn Lys Ile Phe Ala Ser Ile Met Gln Glu Met Asp Lys Lys Leu Thr 
225                 230                 235                 240 


Gln Arg Asn Leu Glu Ser Tyr Gln Lys Asp Ala Lys Glu Leu Lys Asn 
                245                 250                 255     


Lys Arg Asn Arg 
            260 


<210>  16
<211>  31
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  16
aaggatccga gcccacatat tattgaaacc a                                      31


<210>  17
<211>  44
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Primer

<400>  17
caagcttaac tagtggtacc tcggtttctt ttgcctttta attc                        44


<210>  18
<211>  45
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  18
ggtctcggat ccatgaaaaa gattagacga aaagaatatg tttct                       45


<210>  19
<211>  46
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  19
ggtctcaagc ttaactagtg gtaccgaaaa tgctaaagag ttgcgc                      46


<210>  20
<211>  810
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Truncated Helicobacter pylori HpaA


<220>
<221>  CDS
<222>  (1)..(810)

<400>  20
atg cgg ggt tct cat cat cat cat cat cat ggt atg gct agc atg act         48
Met Arg Gly Ser His His His His His His Gly Met Ala Ser Met Thr           
1               5                   10                  15                

ggt gga cag caa atg ggt cgg gat ctg tac gac gat gac gat aag gat         96
Gly Gly Gln Gln Met Gly Arg Asp Leu Tyr Asp Asp Asp Asp Lys Asp           
            20                  25                  30                    

ccg agc cca cat att att gaa acc aat gaa gtc gct ttg aag ttg aat        144
Pro Ser Pro His Ile Ile Glu Thr Asn Glu Val Ala Leu Lys Leu Asn           
        35                  40                  45                        

tac cat cca gct agc gag aaa gtt caa gcg tta gat gaa aag att tta        192
Tyr His Pro Ala Ser Glu Lys Val Gln Ala Leu Asp Glu Lys Ile Leu           
    50                  55                  60                            

ctt tta agg cca gct ttt caa tac agc gat aat att gct aaa gag tat        240
Leu Leu Arg Pro Ala Phe Gln Tyr Ser Asp Asn Ile Ala Lys Glu Tyr           
65                  70                  75                  80            

gaa aac aaa ttc aag aat caa acc gcg ctc aag gtt gaa cag att ttg        288
Glu Asn Lys Phe Lys Asn Gln Thr Ala Leu Lys Val Glu Gln Ile Leu           
                85                  90                  95                

caa aat cag ggc tat aag gtt att agc gta gat agc agc gat aaa gac        336
Gln Asn Gln Gly Tyr Lys Val Ile Ser Val Asp Ser Ser Asp Lys Asp           
            100                 105                 110                   

gat ctt tct ttt tcg caa aaa aaa gaa ggg tat ttg gcc gtc gct atg        384
Asp Leu Ser Phe Ser Gln Lys Lys Glu Gly Tyr Leu Ala Val Ala Met           
        115                 120                 125                       

aat ggc gaa att gtt tta cgc ccc gat cct aaa agg acc ata cag aag        432
Asn Gly Glu Ile Val Leu Arg Pro Asp Pro Lys Arg Thr Ile Gln Lys           
    130                 135                 140                           

aaa tca gaa ccc ggg ttg tta ttc tcc act ggt ttg gat aaa atg gaa        480
Lys Ser Glu Pro Gly Leu Leu Phe Ser Thr Gly Leu Asp Lys Met Glu           
145                 150                 155                 160           

ggg gtt tta atc ccg gct ggg ttt att aag gtt acc ata cta gag cct        528
Gly Val Leu Ile Pro Ala Gly Phe Ile Lys Val Thr Ile Leu Glu Pro           
                165                 170                 175               

atg agt ggg gaa tct ttg gat tct ttt acg atg gat ttg agc gag tta        576
Met Ser Gly Glu Ser Leu Asp Ser Phe Thr Met Asp Leu Ser Glu Leu           
            180                 185                 190                   

gac att caa gaa aaa ttc tta aaa acc acc cat tca agc cat agc ggg        624
Asp Ile Gln Glu Lys Phe Leu Lys Thr Thr His Ser Ser His Ser Gly           
        195                 200                 205                       

ggg tta gtt agc act atg gtt aag gga acg gat aat tct aat gat gcg        672
Gly Leu Val Ser Thr Met Val Lys Gly Thr Asp Asn Ser Asn Asp Ala           
    210                 215                 220                           

atc aag agc gct ttg aat aag att ttt gca aat atc atg caa gaa ata        720
Ile Lys Ser Ala Leu Asn Lys Ile Phe Ala Asn Ile Met Gln Glu Ile           
225                 230                 235                 240           

gac aaa aaa ctc act caa aag aat tta gaa tct tat caa aaa gac gcc        768
Asp Lys Lys Leu Thr Gln Lys Asn Leu Glu Ser Tyr Gln Lys Asp Ala           
                245                 250                 255               

aag gaa tta aaa ggc aaa aga aac cga ggt acc act agt taa                810
Lys Glu Leu Lys Gly Lys Arg Asn Arg Gly Thr Thr Ser                       
            260                 265                                       


<210>  21
<211>  269
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic Construct

<400>  21

Met Arg Gly Ser His His His His His His Gly Met Ala Ser Met Thr 
1               5                   10                  15      


Gly Gly Gln Gln Met Gly Arg Asp Leu Tyr Asp Asp Asp Asp Lys Asp 
            20                  25                  30          


Pro Ser Pro His Ile Ile Glu Thr Asn Glu Val Ala Leu Lys Leu Asn 
        35                  40                  45              


Tyr His Pro Ala Ser Glu Lys Val Gln Ala Leu Asp Glu Lys Ile Leu 
    50                  55                  60                  


Leu Leu Arg Pro Ala Phe Gln Tyr Ser Asp Asn Ile Ala Lys Glu Tyr 
65                  70                  75                  80  


Glu Asn Lys Phe Lys Asn Gln Thr Ala Leu Lys Val Glu Gln Ile Leu 
                85                  90                  95      


Gln Asn Gln Gly Tyr Lys Val Ile Ser Val Asp Ser Ser Asp Lys Asp 
            100                 105                 110         


Asp Leu Ser Phe Ser Gln Lys Lys Glu Gly Tyr Leu Ala Val Ala Met 
        115                 120                 125             


Asn Gly Glu Ile Val Leu Arg Pro Asp Pro Lys Arg Thr Ile Gln Lys 
    130                 135                 140                 


Lys Ser Glu Pro Gly Leu Leu Phe Ser Thr Gly Leu Asp Lys Met Glu 
145                 150                 155                 160 


Gly Val Leu Ile Pro Ala Gly Phe Ile Lys Val Thr Ile Leu Glu Pro 
                165                 170                 175     


Met Ser Gly Glu Ser Leu Asp Ser Phe Thr Met Asp Leu Ser Glu Leu 
            180                 185                 190         


Asp Ile Gln Glu Lys Phe Leu Lys Thr Thr His Ser Ser His Ser Gly 
        195                 200                 205             


Gly Leu Val Ser Thr Met Val Lys Gly Thr Asp Asn Ser Asn Asp Ala 
    210                 215                 220                 


Ile Lys Ser Ala Leu Asn Lys Ile Phe Ala Asn Ile Met Gln Glu Ile 
225                 230                 235                 240 


Asp Lys Lys Leu Thr Gln Lys Asn Leu Glu Ser Tyr Gln Lys Asp Ala 
                245                 250                 255     


Lys Glu Leu Lys Gly Lys Arg Asn Arg Gly Thr Thr Ser 
            260                 265                 


<210>  22
<211>  260
<212>  PRT
<213>  Helicobacter pylori SS1

<400>  22

Met Lys Ala Asn Asn His Phe Lys Asp Phe Ala Trp Lys Lys Cys Leu 
1               5                   10                  15      


Leu Gly Ala Ser Val Ala Ala Leu Leu Val Gly Cys Ser Pro His Ile 
            20                  25                  30          


Ile Glu Thr Asn Glu Val Ala Leu Lys Leu Asn Tyr His Pro Ala Ser 
        35                  40                  45              


Glu Lys Val Gln Ala Leu Asp Glu Lys Ile Leu Leu Leu Arg Pro Ala 
    50                  55                  60                  


Phe Gln Tyr Ser Asp Asn Ile Ala Lys Glu Tyr Glu Asn Lys Phe Lys 
65                  70                  75                  80  


Asn Gln Thr Ala Leu Lys Val Glu Gln Ile Leu Gln Asn Gln Gly Tyr 
                85                  90                  95      


Lys Val Ile Ser Val Asp Ser Ser Asp Lys Asp Asp Leu Ser Phe Ser 
            100                 105                 110         


Gln Lys Lys Glu Gly Tyr Leu Ala Val Ala Met Asn Gly Glu Ile Val 
        115                 120                 125             


Leu Arg Pro Asp Pro Lys Arg Thr Ile Gln Lys Lys Ser Glu Pro Gly 
    130                 135                 140                 


Leu Leu Phe Ser Thr Gly Leu Asp Lys Met Glu Gly Val Leu Ile Pro 
145                 150                 155                 160 


Ala Gly Phe Ile Lys Val Thr Ile Leu Glu Pro Met Ser Gly Glu Ser 
                165                 170                 175     


Leu Asp Ser Phe Thr Met Asp Leu Ser Glu Leu Asp Ile Gln Glu Lys 
            180                 185                 190         


Phe Leu Lys Thr Thr His Ser Ser His Ser Gly Gly Leu Val Ser Thr 
        195                 200                 205             


Met Val Lys Gly Thr Asp Asn Ser Asn Asp Ala Ile Lys Ser Ala Leu 
    210                 215                 220                 


Asn Lys Ile Phe Ala Asn Ile Met Gln Glu Ile Asp Lys Lys Leu Thr 
225                 230                 235                 240 


Gln Lys Asn Leu Glu Ser Tyr Gln Lys Asp Ala Lys Glu Leu Lys Gly 
                245                 250                 255     


Lys Arg Asn Arg 
            260 


