                         SEQUENCE LISTING

<110>  BRISTOW, MICHAEL R.
       PORT, J. DAVID
 
<120>  METHODS AND COMPOSITIONS FOR CARDIOVASCULAR DISEASES AND 
       CONDITIONS

<130>  ARCA.P0024WO

<140>  UNKNOWN
<141>  2010-12-23

<150>  61/289,932
<151>  2009-12-23

<160>  10    

<170>  PatentIn version 3.5

<210>  1
<211>  4345
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (297)..(3908)

<400>  1
actgaaacta ggggcaagga gacgaagaga acatgaaagt taaactttaa gatgaagaac       60

aaagctgaac atactgatgc attggatctt tggagaggat ctcagaactc attgtactta      120

atttacaggc taaaacctta gaagaggaat ttattatatc ctacacaaga ctccagggaa      180

gcacatggcc ttggactgaa ggctggcatc tggaagctgt cagccaccag caccttctgc      240

agcaggaaaa ggccagggct ctgctggagc aggcagcaga gtggacgcac agtaac atg      299
                                                              Met         
                                                              1           

ggc aac ttg aag agc gtg gcc cag gag cct ggg cca ccc tgc ggc ctg        347
Gly Asn Leu Lys Ser Val Ala Gln Glu Pro Gly Pro Pro Cys Gly Leu           
            5                   10                  15                    

ggg ctg ggg ctg ggc ctt ggg ctg tgc ggc aag cag ggc cca gcc acc        395
Gly Leu Gly Leu Gly Leu Gly Leu Cys Gly Lys Gln Gly Pro Ala Thr           
        20                  25                  30                        

ccg gcc cct gag ccc agc cgg gcc cca gca tcc cta ctc cca cca gcg        443
Pro Ala Pro Glu Pro Ser Arg Ala Pro Ala Ser Leu Leu Pro Pro Ala           
    35                  40                  45                            

cca gaa cac agc ccc ccg agc tcc ccg cta acc cag ccc cca gag ggg        491
Pro Glu His Ser Pro Pro Ser Ser Pro Leu Thr Gln Pro Pro Glu Gly           
50                  55                  60                  65            

ccc aag ttc cct cgt gtg aag aac tgg gag gtg ggg agc atc acc tat        539
Pro Lys Phe Pro Arg Val Lys Asn Trp Glu Val Gly Ser Ile Thr Tyr           
                70                  75                  80                

gac acc ctc agc gcc cag gcg cag cag gat ggg ccc tgc acc cca aga        587
Asp Thr Leu Ser Ala Gln Ala Gln Gln Asp Gly Pro Cys Thr Pro Arg           
            85                  90                  95                    

cgc tgc ctg ggc tcc ctg gta ttt cca cgg aaa cta cag ggc cgg ccc        635
Arg Cys Leu Gly Ser Leu Val Phe Pro Arg Lys Leu Gln Gly Arg Pro           
        100                 105                 110                       

tcc ccc ggc ccc ccg gcc cct gag cag ctg ctg agt cag gcc cgg gac        683
Ser Pro Gly Pro Pro Ala Pro Glu Gln Leu Leu Ser Gln Ala Arg Asp           
    115                 120                 125                           

ttc atc aac cag tac tac agc tcc att aag agg agc ggc tcc cag gcc        731
Phe Ile Asn Gln Tyr Tyr Ser Ser Ile Lys Arg Ser Gly Ser Gln Ala           
130                 135                 140                 145           

cac gaa cag cgg ctt caa gag gtg gaa gcc gag gtg gca gcc aca ggc        779
His Glu Gln Arg Leu Gln Glu Val Glu Ala Glu Val Ala Ala Thr Gly           
                150                 155                 160               

acc tac cag ctt agg gag agc gag ctg gtg ttc ggg gct aag cag gcc        827
Thr Tyr Gln Leu Arg Glu Ser Glu Leu Val Phe Gly Ala Lys Gln Ala           
            165                 170                 175                   

tgg cgc aac gct ccc cgc tgc gtg ggc cgg atc cag tgg ggg aag ctg        875
Trp Arg Asn Ala Pro Arg Cys Val Gly Arg Ile Gln Trp Gly Lys Leu           
        180                 185                 190                       

cag gtg ttc gat gcc cgg gac tgc agg tct gca cag gaa atg ttc acc        923
Gln Val Phe Asp Ala Arg Asp Cys Arg Ser Ala Gln Glu Met Phe Thr           
    195                 200                 205                           

tac atc tgc aac cac atc aag tat gcc acc aac cgg ggc aac ctt cgc        971
Tyr Ile Cys Asn His Ile Lys Tyr Ala Thr Asn Arg Gly Asn Leu Arg           
210                 215                 220                 225           

tcg gcc atc aca gtg ttc ccg cag cgc tgc cct ggc cga gga gac ttc       1019
Ser Ala Ile Thr Val Phe Pro Gln Arg Cys Pro Gly Arg Gly Asp Phe           
                230                 235                 240               

cga atc tgg aac agc cag ctg gtg cgc tac gcg ggc tac cgg cag cag       1067
Arg Ile Trp Asn Ser Gln Leu Val Arg Tyr Ala Gly Tyr Arg Gln Gln           
            245                 250                 255                   

gat ggc tct gtg cgg ggg gac cca gcc aac gtg gag atc acc gag ctc       1115
Asp Gly Ser Val Arg Gly Asp Pro Ala Asn Val Glu Ile Thr Glu Leu           
        260                 265                 270                       

tgc att cag cac ggc tgg acc cca gga aac ggt cgc ttc gac gtg ctg       1163
Cys Ile Gln His Gly Trp Thr Pro Gly Asn Gly Arg Phe Asp Val Leu           
    275                 280                 285                           

ccc ctg ctg ctg cag gcc cca gat gag ccc cca gaa ctc ttc ctt ctg       1211
Pro Leu Leu Leu Gln Ala Pro Asp Glu Pro Pro Glu Leu Phe Leu Leu           
290                 295                 300                 305           

ccc ccc gag ctg gtc ctt gag gtg ccc ctg gag cac ccc acg ctg gag       1259
Pro Pro Glu Leu Val Leu Glu Val Pro Leu Glu His Pro Thr Leu Glu           
                310                 315                 320               

tgg ttt gca gcc ctg ggc ctg cgc tgg tac gcc ctc ccg gca gtg tcc       1307
Trp Phe Ala Ala Leu Gly Leu Arg Trp Tyr Ala Leu Pro Ala Val Ser           
            325                 330                 335                   

aac atg ctg ctg gaa att ggg ggc ctg gag ttc ccc gca gcc ccc ttc       1355
Asn Met Leu Leu Glu Ile Gly Gly Leu Glu Phe Pro Ala Ala Pro Phe           
        340                 345                 350                       

agt ggc tgg tac atg agc act gag atc ggc acg agg aac ctg tgt gac       1403
Ser Gly Trp Tyr Met Ser Thr Glu Ile Gly Thr Arg Asn Leu Cys Asp           
    355                 360                 365                           

cct cac cgc tac aac atc ctg gag gat gtg gct gtc tgc atg gac ctg       1451
Pro His Arg Tyr Asn Ile Leu Glu Asp Val Ala Val Cys Met Asp Leu           
370                 375                 380                 385           

gat acc cgg acc acc tcg tcc ctg tgg aaa gac aag gca gca gtg gaa       1499
Asp Thr Arg Thr Thr Ser Ser Leu Trp Lys Asp Lys Ala Ala Val Glu           
                390                 395                 400               

atc aac gtg gcc gtg ctg cac agt tac cag cta gcc aaa gtc acc atc       1547
Ile Asn Val Ala Val Leu His Ser Tyr Gln Leu Ala Lys Val Thr Ile           
            405                 410                 415                   

gtg gac cac cac gcc gcc acg gcc tct ttc atg aag cac ctg gag aat       1595
Val Asp His His Ala Ala Thr Ala Ser Phe Met Lys His Leu Glu Asn           
        420                 425                 430                       

gag cag aag gcc agg ggg ggc tgc cct gca gac tgg gcc tgg atc gtg       1643
Glu Gln Lys Ala Arg Gly Gly Cys Pro Ala Asp Trp Ala Trp Ile Val           
    435                 440                 445                           

ccc ccc atc tcg ggc agc ctc act cct gtt ttc cat cag gag atg gtc       1691
Pro Pro Ile Ser Gly Ser Leu Thr Pro Val Phe His Gln Glu Met Val           
450                 455                 460                 465           

aac tat ttc ctg tcc ccg gcc ttc cgc tac cag cca gac ccc tgg aag       1739
Asn Tyr Phe Leu Ser Pro Ala Phe Arg Tyr Gln Pro Asp Pro Trp Lys           
                470                 475                 480               

ggg agt gcc gcc aag ggc acc ggc atc acc agg aag aag acc ttt aaa       1787
Gly Ser Ala Ala Lys Gly Thr Gly Ile Thr Arg Lys Lys Thr Phe Lys           
            485                 490                 495                   

gaa gtg gcc aac gcc gtg aag atc tcc gcc tcg ctc atg ggc acg gtg       1835
Glu Val Ala Asn Ala Val Lys Ile Ser Ala Ser Leu Met Gly Thr Val           
        500                 505                 510                       

atg gcg aag cga gtg aag gcg aca atc ctg tat ggc tcc gag acc ggc       1883
Met Ala Lys Arg Val Lys Ala Thr Ile Leu Tyr Gly Ser Glu Thr Gly           
    515                 520                 525                           

cgg gcc cag agc tac gca cag cag ctg ggg aga ctc ttc cgg aag gct       1931
Arg Ala Gln Ser Tyr Ala Gln Gln Leu Gly Arg Leu Phe Arg Lys Ala           
530                 535                 540                 545           

ttt gat ccc cgg gtc ctg tgt atg gat gag tat gac gtg gtg tcc ctc       1979
Phe Asp Pro Arg Val Leu Cys Met Asp Glu Tyr Asp Val Val Ser Leu           
                550                 555                 560               

gaa cac gag acg ctg gtg ctg gtg gta acc agc aca ttt ggg aat ggg       2027
Glu His Glu Thr Leu Val Leu Val Val Thr Ser Thr Phe Gly Asn Gly           
            565                 570                 575                   

gat ccc ccg gag aat gga gag agc ttt gca gct gcc ctg atg gag atg       2075
Asp Pro Pro Glu Asn Gly Glu Ser Phe Ala Ala Ala Leu Met Glu Met           
        580                 585                 590                       

tcc ggc ccc tac aac agc tcc cct cgg ccg gaa cag cac aag agt tat       2123
Ser Gly Pro Tyr Asn Ser Ser Pro Arg Pro Glu Gln His Lys Ser Tyr           
    595                 600                 605                           

aag atc cgc ttc aac agc atc tcc tgc tca gac cca ctg gtg tcc tct       2171
Lys Ile Arg Phe Asn Ser Ile Ser Cys Ser Asp Pro Leu Val Ser Ser           
610                 615                 620                 625           

tgg cgg cgg aag agg aag gag tcc agt aac aca gac agt gca ggg gcc       2219
Trp Arg Arg Lys Arg Lys Glu Ser Ser Asn Thr Asp Ser Ala Gly Ala           
                630                 635                 640               

ctg ggc acc ctc agg ttc tgt gtg ttc ggg ctc ggc tcc cgg gca tac       2267
Leu Gly Thr Leu Arg Phe Cys Val Phe Gly Leu Gly Ser Arg Ala Tyr           
            645                 650                 655                   

ccc cac ttc tgc gcc ttt gct cgt gcc gtg gac aca cgg ctg gag gaa       2315
Pro His Phe Cys Ala Phe Ala Arg Ala Val Asp Thr Arg Leu Glu Glu           
        660                 665                 670                       

ctg ggc ggg gag cgg ctg ctg cag ctg ggc cag ggc gac gag ctg tgc       2363
Leu Gly Gly Glu Arg Leu Leu Gln Leu Gly Gln Gly Asp Glu Leu Cys           
    675                 680                 685                           

ggc cag gag gag gcc ttc cga ggc tgg gcc cag gct gcc ttc cag gcc       2411
Gly Gln Glu Glu Ala Phe Arg Gly Trp Ala Gln Ala Ala Phe Gln Ala           
690                 695                 700                 705           

gcc tgt gag acc ttc tgt gtg gga gag gat gcc aag gcc gcc gcc cga       2459
Ala Cys Glu Thr Phe Cys Val Gly Glu Asp Ala Lys Ala Ala Ala Arg           
                710                 715                 720               

gac atc ttc agc ccc aaa cgg agc tgg aag cgc cag agg tac cgg ctg       2507
Asp Ile Phe Ser Pro Lys Arg Ser Trp Lys Arg Gln Arg Tyr Arg Leu           
            725                 730                 735                   

agc gcc cag gcc gag ggc ctg cag ttg ctg cca ggt ctg atc cac gtg       2555
Ser Ala Gln Ala Glu Gly Leu Gln Leu Leu Pro Gly Leu Ile His Val           
        740                 745                 750                       

cac agg cgg aag atg ttc cag gct aca atc cgc tca gtg gaa aac ctg       2603
His Arg Arg Lys Met Phe Gln Ala Thr Ile Arg Ser Val Glu Asn Leu           
    755                 760                 765                           

caa agc agc aag tcc acg agg gcc acc atc ctg gtg cgc ctg gac acc       2651
Gln Ser Ser Lys Ser Thr Arg Ala Thr Ile Leu Val Arg Leu Asp Thr           
770                 775                 780                 785           

gga ggc cag gag ggg ctg cag tac cag ccg ggg gac cac ata ggt gtc       2699
Gly Gly Gln Glu Gly Leu Gln Tyr Gln Pro Gly Asp His Ile Gly Val           
                790                 795                 800               

tgc ccg ccc aac cgg ccc ggc ctt gtg gag gcg ctg ctg agc cgc gtg       2747
Cys Pro Pro Asn Arg Pro Gly Leu Val Glu Ala Leu Leu Ser Arg Val           
            805                 810                 815                   

gag gac ccg ccg gcg ccc act gag ccc gtg gca gta gag cag ctg gag       2795
Glu Asp Pro Pro Ala Pro Thr Glu Pro Val Ala Val Glu Gln Leu Glu           
        820                 825                 830                       

aag ggc agc cct ggt ggc cct ccc ccc ggc tgg gtg cgg gac ccc cgg       2843
Lys Gly Ser Pro Gly Gly Pro Pro Pro Gly Trp Val Arg Asp Pro Arg           
    835                 840                 845                           

ctg ccc ccg tgc acg ctg cgc cag gct ctc acc ttc ttc ctg gac atc       2891
Leu Pro Pro Cys Thr Leu Arg Gln Ala Leu Thr Phe Phe Leu Asp Ile           
850                 855                 860                 865           

acc tcc cca ccc agc cct cag ctc ttg cgg ctg ctc agc acc ttg gca       2939
Thr Ser Pro Pro Ser Pro Gln Leu Leu Arg Leu Leu Ser Thr Leu Ala           
                870                 875                 880               

gaa gag ccc agg gaa cag cag gag ctg gag gcc ctc agc cag gat ccc       2987
Glu Glu Pro Arg Glu Gln Gln Glu Leu Glu Ala Leu Ser Gln Asp Pro           
            885                 890                 895                   

cga cgc tac gag gag tgg aag tgg ttc cgc tgc ccc acg ctg ctg gag       3035
Arg Arg Tyr Glu Glu Trp Lys Trp Phe Arg Cys Pro Thr Leu Leu Glu           
        900                 905                 910                       

gtg ctg gag cag ttc ccg tcg gtg gcg ctg cct gcc cca ctg ctc ctc       3083
Val Leu Glu Gln Phe Pro Ser Val Ala Leu Pro Ala Pro Leu Leu Leu           
    915                 920                 925                           

acc cag ctg cct ctg ctc cag ccc cgg tac tac tca gtc agc tcg gca       3131
Thr Gln Leu Pro Leu Leu Gln Pro Arg Tyr Tyr Ser Val Ser Ser Ala           
930                 935                 940                 945           

ccc agc acc cac cca gga gag atc cac ctc act gta gct gtg ctg gca       3179
Pro Ser Thr His Pro Gly Glu Ile His Leu Thr Val Ala Val Leu Ala           
                950                 955                 960               

tac agg act cag gat ggg ctg ggc ccc ctg cac tat gga gtc tgc tcc       3227
Tyr Arg Thr Gln Asp Gly Leu Gly Pro Leu His Tyr Gly Val Cys Ser           
            965                 970                 975                   

acg tgg cta agc cag ctc aag ccc gga gac cct gtg ccc tgc ttc atc       3275
Thr Trp Leu Ser Gln Leu Lys Pro Gly Asp Pro Val Pro Cys Phe Ile           
        980                 985                 990                       

cgg ggg gct ccc tcc ttc cgg  ctg cca ccc gat ccc  agc ttg ccc tgc     3323
Arg Gly Ala Pro Ser Phe Arg  Leu Pro Pro Asp Pro  Ser Leu Pro Cys         
    995                 1000                 1005                         

atc  ctg gtg ggt cca ggc  act ggc att gcc ccc  ttc cgg gga ttc        3368
Ile  Leu Val Gly Pro Gly  Thr Gly Ile Ala Pro  Phe Arg Gly Phe            
1010                 1015                 1020                            

tgg  cag gag cgg ctg cat  gac att gag agc aaa  ggg ctg cag ccc        3413
Trp  Gln Glu Arg Leu His  Asp Ile Glu Ser Lys  Gly Leu Gln Pro            
1025                 1030                 1035                            

act  ccc atg act ttg gtg  ttc ggc tgc cga tgc  tcc caa ctt gac        3458
Thr  Pro Met Thr Leu Val  Phe Gly Cys Arg Cys  Ser Gln Leu Asp            
1040                 1045                 1050                            

cat  ctc tac cgc gac gag  gtg cag aac gcc cag  cag cgc ggg gtg        3503
His  Leu Tyr Arg Asp Glu  Val Gln Asn Ala Gln  Gln Arg Gly Val            
1055                 1060                 1065                            

ttt  ggc cga gtc ctc acc  gcc ttc tcc cgg gaa  cct gac aac ccc        3548
Phe  Gly Arg Val Leu Thr  Ala Phe Ser Arg Glu  Pro Asp Asn Pro            
1070                 1075                 1080                            

aag  acc tac gtg cag gac  atc ctg agg acg gag  ctg gct gcg gag        3593
Lys  Thr Tyr Val Gln Asp  Ile Leu Arg Thr Glu  Leu Ala Ala Glu            
1085                 1090                 1095                            

gtg  cac cgc gtg ctg tgc  ctc gag cgg ggc cac  atg ttt gtc tgc        3638
Val  His Arg Val Leu Cys  Leu Glu Arg Gly His  Met Phe Val Cys            
1100                 1105                 1110                            

ggc  gat gtt acc atg gca  acc aac gtc ctg cag  acc gtg cag cgc        3683
Gly  Asp Val Thr Met Ala  Thr Asn Val Leu Gln  Thr Val Gln Arg            
1115                 1120                 1125                            

atc  ctg gcg acg gag ggc  gac atg gag ctg gac  gag gcc ggc gac        3728
Ile  Leu Ala Thr Glu Gly  Asp Met Glu Leu Asp  Glu Ala Gly Asp            
1130                 1135                 1140                            

gtc  atc ggc gtg ctg cgg  gat cag caa cgc tac  cac gaa gac att        3773
Val  Ile Gly Val Leu Arg  Asp Gln Gln Arg Tyr  His Glu Asp Ile            
1145                 1150                 1155                            

ttc  ggg ctc acg ctg cgc  acc cag gag gtg aca  agc cgc ata cgc        3818
Phe  Gly Leu Thr Leu Arg  Thr Gln Glu Val Thr  Ser Arg Ile Arg            
1160                 1165                 1170                            

acc  cag agc ttt tcc ttg  cag gag cgt cag ttg  cgg ggc gca gtg        3863
Thr  Gln Ser Phe Ser Leu  Gln Glu Arg Gln Leu  Arg Gly Ala Val            
1175                 1180                 1185                            

ccc  tgg gcg ttc gac cct  ccc ggc tca gac acc  aac agc ccc tga        3908
Pro  Trp Ala Phe Asp Pro  Pro Gly Ser Asp Thr  Asn Ser Pro                
1190                 1195                 1200                            

gagccgcctg gctttccctt ccagttccgg gagagcggct gcccgactca ggtccgcccg     3968

accaggatca gccccgctcc tcccctcttg aggtggtgcc ttctcacatc tgtccagagg     4028

ctgcaaggat tcagcattat tcctccagga aggagcaaaa cgcctctttt ccctctctag     4088

gcctgttgcc tcgggcctgg gtccgcctta atctggaagg cccctcccag cagcggtacc     4148

ccagggccta ctgccacccg cttcctgttt cttagtcgaa tgttagattc ctcttgcctc     4208

tctcaggagt atcttacctg taaagtctaa tctctaaatc aagtatttat tattgaagat     4268

ttaccataag ggactgtgcc agatgttagg agaactacta aagtgcctac cccagctcat     4328

gtggattaca aaaaaaa                                                    4345


<210>  2
<211>  1203
<212>  PRT
<213>  Homo sapiens

<400>  2

Met Gly Asn Leu Lys Ser Val Ala Gln Glu Pro Gly Pro Pro Cys Gly 
1               5                   10                  15      


Leu Gly Leu Gly Leu Gly Leu Gly Leu Cys Gly Lys Gln Gly Pro Ala 
            20                  25                  30          


Thr Pro Ala Pro Glu Pro Ser Arg Ala Pro Ala Ser Leu Leu Pro Pro 
        35                  40                  45              


Ala Pro Glu His Ser Pro Pro Ser Ser Pro Leu Thr Gln Pro Pro Glu 
    50                  55                  60                  


Gly Pro Lys Phe Pro Arg Val Lys Asn Trp Glu Val Gly Ser Ile Thr 
65                  70                  75                  80  


Tyr Asp Thr Leu Ser Ala Gln Ala Gln Gln Asp Gly Pro Cys Thr Pro 
                85                  90                  95      


Arg Arg Cys Leu Gly Ser Leu Val Phe Pro Arg Lys Leu Gln Gly Arg 
            100                 105                 110         


Pro Ser Pro Gly Pro Pro Ala Pro Glu Gln Leu Leu Ser Gln Ala Arg 
        115                 120                 125             


Asp Phe Ile Asn Gln Tyr Tyr Ser Ser Ile Lys Arg Ser Gly Ser Gln 
    130                 135                 140                 


Ala His Glu Gln Arg Leu Gln Glu Val Glu Ala Glu Val Ala Ala Thr 
145                 150                 155                 160 


Gly Thr Tyr Gln Leu Arg Glu Ser Glu Leu Val Phe Gly Ala Lys Gln 
                165                 170                 175     


Ala Trp Arg Asn Ala Pro Arg Cys Val Gly Arg Ile Gln Trp Gly Lys 
            180                 185                 190         


Leu Gln Val Phe Asp Ala Arg Asp Cys Arg Ser Ala Gln Glu Met Phe 
        195                 200                 205             


Thr Tyr Ile Cys Asn His Ile Lys Tyr Ala Thr Asn Arg Gly Asn Leu 
    210                 215                 220                 


Arg Ser Ala Ile Thr Val Phe Pro Gln Arg Cys Pro Gly Arg Gly Asp 
225                 230                 235                 240 


Phe Arg Ile Trp Asn Ser Gln Leu Val Arg Tyr Ala Gly Tyr Arg Gln 
                245                 250                 255     


Gln Asp Gly Ser Val Arg Gly Asp Pro Ala Asn Val Glu Ile Thr Glu 
            260                 265                 270         


Leu Cys Ile Gln His Gly Trp Thr Pro Gly Asn Gly Arg Phe Asp Val 
        275                 280                 285             


Leu Pro Leu Leu Leu Gln Ala Pro Asp Glu Pro Pro Glu Leu Phe Leu 
    290                 295                 300                 


Leu Pro Pro Glu Leu Val Leu Glu Val Pro Leu Glu His Pro Thr Leu 
305                 310                 315                 320 


Glu Trp Phe Ala Ala Leu Gly Leu Arg Trp Tyr Ala Leu Pro Ala Val 
                325                 330                 335     


Ser Asn Met Leu Leu Glu Ile Gly Gly Leu Glu Phe Pro Ala Ala Pro 
            340                 345                 350         


Phe Ser Gly Trp Tyr Met Ser Thr Glu Ile Gly Thr Arg Asn Leu Cys 
        355                 360                 365             


Asp Pro His Arg Tyr Asn Ile Leu Glu Asp Val Ala Val Cys Met Asp 
    370                 375                 380                 


Leu Asp Thr Arg Thr Thr Ser Ser Leu Trp Lys Asp Lys Ala Ala Val 
385                 390                 395                 400 


Glu Ile Asn Val Ala Val Leu His Ser Tyr Gln Leu Ala Lys Val Thr 
                405                 410                 415     


Ile Val Asp His His Ala Ala Thr Ala Ser Phe Met Lys His Leu Glu 
            420                 425                 430         


Asn Glu Gln Lys Ala Arg Gly Gly Cys Pro Ala Asp Trp Ala Trp Ile 
        435                 440                 445             


Val Pro Pro Ile Ser Gly Ser Leu Thr Pro Val Phe His Gln Glu Met 
    450                 455                 460                 


Val Asn Tyr Phe Leu Ser Pro Ala Phe Arg Tyr Gln Pro Asp Pro Trp 
465                 470                 475                 480 


Lys Gly Ser Ala Ala Lys Gly Thr Gly Ile Thr Arg Lys Lys Thr Phe 
                485                 490                 495     


Lys Glu Val Ala Asn Ala Val Lys Ile Ser Ala Ser Leu Met Gly Thr 
            500                 505                 510         


Val Met Ala Lys Arg Val Lys Ala Thr Ile Leu Tyr Gly Ser Glu Thr 
        515                 520                 525             


Gly Arg Ala Gln Ser Tyr Ala Gln Gln Leu Gly Arg Leu Phe Arg Lys 
    530                 535                 540                 


Ala Phe Asp Pro Arg Val Leu Cys Met Asp Glu Tyr Asp Val Val Ser 
545                 550                 555                 560 


Leu Glu His Glu Thr Leu Val Leu Val Val Thr Ser Thr Phe Gly Asn 
                565                 570                 575     


Gly Asp Pro Pro Glu Asn Gly Glu Ser Phe Ala Ala Ala Leu Met Glu 
            580                 585                 590         


Met Ser Gly Pro Tyr Asn Ser Ser Pro Arg Pro Glu Gln His Lys Ser 
        595                 600                 605             


Tyr Lys Ile Arg Phe Asn Ser Ile Ser Cys Ser Asp Pro Leu Val Ser 
    610                 615                 620                 


Ser Trp Arg Arg Lys Arg Lys Glu Ser Ser Asn Thr Asp Ser Ala Gly 
625                 630                 635                 640 


Ala Leu Gly Thr Leu Arg Phe Cys Val Phe Gly Leu Gly Ser Arg Ala 
                645                 650                 655     


Tyr Pro His Phe Cys Ala Phe Ala Arg Ala Val Asp Thr Arg Leu Glu 
            660                 665                 670         


Glu Leu Gly Gly Glu Arg Leu Leu Gln Leu Gly Gln Gly Asp Glu Leu 
        675                 680                 685             


Cys Gly Gln Glu Glu Ala Phe Arg Gly Trp Ala Gln Ala Ala Phe Gln 
    690                 695                 700                 


Ala Ala Cys Glu Thr Phe Cys Val Gly Glu Asp Ala Lys Ala Ala Ala 
705                 710                 715                 720 


Arg Asp Ile Phe Ser Pro Lys Arg Ser Trp Lys Arg Gln Arg Tyr Arg 
                725                 730                 735     


Leu Ser Ala Gln Ala Glu Gly Leu Gln Leu Leu Pro Gly Leu Ile His 
            740                 745                 750         


Val His Arg Arg Lys Met Phe Gln Ala Thr Ile Arg Ser Val Glu Asn 
        755                 760                 765             


Leu Gln Ser Ser Lys Ser Thr Arg Ala Thr Ile Leu Val Arg Leu Asp 
    770                 775                 780                 


Thr Gly Gly Gln Glu Gly Leu Gln Tyr Gln Pro Gly Asp His Ile Gly 
785                 790                 795                 800 


Val Cys Pro Pro Asn Arg Pro Gly Leu Val Glu Ala Leu Leu Ser Arg 
                805                 810                 815     


Val Glu Asp Pro Pro Ala Pro Thr Glu Pro Val Ala Val Glu Gln Leu 
            820                 825                 830         


Glu Lys Gly Ser Pro Gly Gly Pro Pro Pro Gly Trp Val Arg Asp Pro 
        835                 840                 845             


Arg Leu Pro Pro Cys Thr Leu Arg Gln Ala Leu Thr Phe Phe Leu Asp 
    850                 855                 860                 


Ile Thr Ser Pro Pro Ser Pro Gln Leu Leu Arg Leu Leu Ser Thr Leu 
865                 870                 875                 880 


Ala Glu Glu Pro Arg Glu Gln Gln Glu Leu Glu Ala Leu Ser Gln Asp 
                885                 890                 895     


Pro Arg Arg Tyr Glu Glu Trp Lys Trp Phe Arg Cys Pro Thr Leu Leu 
            900                 905                 910         


Glu Val Leu Glu Gln Phe Pro Ser Val Ala Leu Pro Ala Pro Leu Leu 
        915                 920                 925             


Leu Thr Gln Leu Pro Leu Leu Gln Pro Arg Tyr Tyr Ser Val Ser Ser 
    930                 935                 940                 


Ala Pro Ser Thr His Pro Gly Glu Ile His Leu Thr Val Ala Val Leu 
945                 950                 955                 960 


Ala Tyr Arg Thr Gln Asp Gly Leu Gly Pro Leu His Tyr Gly Val Cys 
                965                 970                 975     


Ser Thr Trp Leu Ser Gln Leu Lys Pro Gly Asp Pro Val Pro Cys Phe 
            980                 985                 990         


Ile Arg Gly Ala Pro Ser Phe Arg  Leu Pro Pro Asp Pro  Ser Leu Pro 
        995                 1000                 1005             


Cys Ile  Leu Val Gly Pro Gly  Thr Gly Ile Ala Pro  Phe Arg Gly 
    1010                 1015                 1020             


Phe Trp  Gln Glu Arg Leu His  Asp Ile Glu Ser Lys  Gly Leu Gln 
    1025                 1030                 1035             


Pro Thr  Pro Met Thr Leu Val  Phe Gly Cys Arg Cys  Ser Gln Leu 
    1040                 1045                 1050             


Asp His  Leu Tyr Arg Asp Glu  Val Gln Asn Ala Gln  Gln Arg Gly 
    1055                 1060                 1065             


Val Phe  Gly Arg Val Leu Thr  Ala Phe Ser Arg Glu  Pro Asp Asn 
    1070                 1075                 1080             


Pro Lys  Thr Tyr Val Gln Asp  Ile Leu Arg Thr Glu  Leu Ala Ala 
    1085                 1090                 1095             


Glu Val  His Arg Val Leu Cys  Leu Glu Arg Gly His  Met Phe Val 
    1100                 1105                 1110             


Cys Gly  Asp Val Thr Met Ala  Thr Asn Val Leu Gln  Thr Val Gln 
    1115                 1120                 1125             


Arg Ile  Leu Ala Thr Glu Gly  Asp Met Glu Leu Asp  Glu Ala Gly 
    1130                 1135                 1140             


Asp Val  Ile Gly Val Leu Arg  Asp Gln Gln Arg Tyr  His Glu Asp 
    1145                 1150                 1155             


Ile Phe  Gly Leu Thr Leu Arg  Thr Gln Glu Val Thr  Ser Arg Ile 
    1160                 1165                 1170             


Arg Thr  Gln Ser Phe Ser Leu  Gln Glu Arg Gln Leu  Arg Gly Ala 
    1175                 1180                 1185             


Val Pro  Trp Ala Phe Asp Pro  Pro Gly Ser Asp Thr  Asn Ser Pro 
    1190                 1195                 1200             


<210>  3
<211>  4345
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (297)..(3908)

<400>  3
actgaaacta ggggcaagga gacgaagaga acatgaaagt taaactttaa gatgaagaac       60

aaagctgaac atactgatgc attggatctt tggagaggat ctcagaactc attgtactta      120

atttacaggc taaaacctta gaagaggaat ttattatatc ctacacaaga ctccagggaa      180

gcacatggcc ttggactgaa ggctggcatc tggaagctgt cagccaccag caccttctgc      240

agcaggaaaa ggccagggct ctgctggagc aggcagcaga gtggacgcac agtaac atg      299
                                                              Met         
                                                              1           

ggc aac ttg aag agc gtg gcc cag gag cct ggg cca ccc tgc ggc ctg        347
Gly Asn Leu Lys Ser Val Ala Gln Glu Pro Gly Pro Pro Cys Gly Leu           
            5                   10                  15                    

ggg ctg ggg ctg ggc ctt ggg ctg tgc ggc aag cag ggc cca gcc acc        395
Gly Leu Gly Leu Gly Leu Gly Leu Cys Gly Lys Gln Gly Pro Ala Thr           
        20                  25                  30                        

ccg gcc cct gag ccc agc cgg gcc cca gca tcc cta ctc cca cca gcg        443
Pro Ala Pro Glu Pro Ser Arg Ala Pro Ala Ser Leu Leu Pro Pro Ala           
    35                  40                  45                            

cca gaa cac agc ccc ccg agc tcc ccg cta acc cag ccc cca gag ggg        491
Pro Glu His Ser Pro Pro Ser Ser Pro Leu Thr Gln Pro Pro Glu Gly           
50                  55                  60                  65            

ccc aag ttc cct cgt gtg aag aac tgg gag gtg ggg agc atc acc tat        539
Pro Lys Phe Pro Arg Val Lys Asn Trp Glu Val Gly Ser Ile Thr Tyr           
                70                  75                  80                

gac acc ctc agc gcc cag gcg cag cag gat ggg ccc tgc acc cca aga        587
Asp Thr Leu Ser Ala Gln Ala Gln Gln Asp Gly Pro Cys Thr Pro Arg           
            85                  90                  95                    

cgc tgc ctg ggc tcc ctg gta ttt cca cgg aaa cta cag ggc cgg ccc        635
Arg Cys Leu Gly Ser Leu Val Phe Pro Arg Lys Leu Gln Gly Arg Pro           
        100                 105                 110                       

tcc ccc ggc ccc ccg gcc cct gag cag ctg ctg agt cag gcc cgg gac        683
Ser Pro Gly Pro Pro Ala Pro Glu Gln Leu Leu Ser Gln Ala Arg Asp           
    115                 120                 125                           

ttc atc aac cag tac tac agc tcc att aag agg agc ggc tcc cag gcc        731
Phe Ile Asn Gln Tyr Tyr Ser Ser Ile Lys Arg Ser Gly Ser Gln Ala           
130                 135                 140                 145           

cac gaa cag cgg ctt caa gag gtg gaa gcc gag gtg gca gcc aca ggc        779
His Glu Gln Arg Leu Gln Glu Val Glu Ala Glu Val Ala Ala Thr Gly           
                150                 155                 160               

acc tac cag ctt agg gag agc gag ctg gtg ttc ggg gct aag cag gcc        827
Thr Tyr Gln Leu Arg Glu Ser Glu Leu Val Phe Gly Ala Lys Gln Ala           
            165                 170                 175                   

tgg cgc aac gct ccc cgc tgc gtg ggc cgg atc cag tgg ggg aag ctg        875
Trp Arg Asn Ala Pro Arg Cys Val Gly Arg Ile Gln Trp Gly Lys Leu           
        180                 185                 190                       

cag gtg ttc gat gcc cgg gac tgc agg tct gca cag gaa atg ttc acc        923
Gln Val Phe Asp Ala Arg Asp Cys Arg Ser Ala Gln Glu Met Phe Thr           
    195                 200                 205                           

tac atc tgc aac cac atc aag tat gcc acc aac cgg ggc aac ctt cgc        971
Tyr Ile Cys Asn His Ile Lys Tyr Ala Thr Asn Arg Gly Asn Leu Arg           
210                 215                 220                 225           

tcg gcc atc aca gtg ttc ccg cag cgc tgc cct ggc cga gga gac ttc       1019
Ser Ala Ile Thr Val Phe Pro Gln Arg Cys Pro Gly Arg Gly Asp Phe           
                230                 235                 240               

cga atc tgg aac agc cag ctg gtg cgc tac gcg ggc tac cgg cag cag       1067
Arg Ile Trp Asn Ser Gln Leu Val Arg Tyr Ala Gly Tyr Arg Gln Gln           
            245                 250                 255                   

gat ggc tct gtg cgg ggg gac cca gcc aac gtg gag atc acc gag ctc       1115
Asp Gly Ser Val Arg Gly Asp Pro Ala Asn Val Glu Ile Thr Glu Leu           
        260                 265                 270                       

tgc att cag cac ggc tgg acc cca gga aac ggt cgc ttc gac gtg ctg       1163
Cys Ile Gln His Gly Trp Thr Pro Gly Asn Gly Arg Phe Asp Val Leu           
    275                 280                 285                           

ccc ctg ctg ctg cag gcc cca gat gat ccc cca gaa ctc ttc ctt ctg       1211
Pro Leu Leu Leu Gln Ala Pro Asp Asp Pro Pro Glu Leu Phe Leu Leu           
290                 295                 300                 305           

ccc ccc gag ctg gtc ctt gag gtg ccc ctg gag cac ccc acg ctg gag       1259
Pro Pro Glu Leu Val Leu Glu Val Pro Leu Glu His Pro Thr Leu Glu           
                310                 315                 320               

tgg ttt gca gcc ctg ggc ctg cgc tgg tac gcc ctc ccg gca gtg tcc       1307
Trp Phe Ala Ala Leu Gly Leu Arg Trp Tyr Ala Leu Pro Ala Val Ser           
            325                 330                 335                   

aac atg ctg ctg gaa att ggg ggc ctg gag ttc ccc gca gcc ccc ttc       1355
Asn Met Leu Leu Glu Ile Gly Gly Leu Glu Phe Pro Ala Ala Pro Phe           
        340                 345                 350                       

agt ggc tgg tac atg agc act gag atc ggc acg agg aac ctg tgt gac       1403
Ser Gly Trp Tyr Met Ser Thr Glu Ile Gly Thr Arg Asn Leu Cys Asp           
    355                 360                 365                           

cct cac cgc tac aac atc ctg gag gat gtg gct gtc tgc atg gac ctg       1451
Pro His Arg Tyr Asn Ile Leu Glu Asp Val Ala Val Cys Met Asp Leu           
370                 375                 380                 385           

gat acc cgg acc acc tcg tcc ctg tgg aaa gac aag gca gca gtg gaa       1499
Asp Thr Arg Thr Thr Ser Ser Leu Trp Lys Asp Lys Ala Ala Val Glu           
                390                 395                 400               

atc aac gtg gcc gtg ctg cac agt tac cag cta gcc aaa gtc acc atc       1547
Ile Asn Val Ala Val Leu His Ser Tyr Gln Leu Ala Lys Val Thr Ile           
            405                 410                 415                   

gtg gac cac cac gcc gcc acg gcc tct ttc atg aag cac ctg gag aat       1595
Val Asp His His Ala Ala Thr Ala Ser Phe Met Lys His Leu Glu Asn           
        420                 425                 430                       

gag cag aag gcc agg ggg ggc tgc cct gca gac tgg gcc tgg atc gtg       1643
Glu Gln Lys Ala Arg Gly Gly Cys Pro Ala Asp Trp Ala Trp Ile Val           
    435                 440                 445                           

ccc ccc atc tcg ggc agc ctc act cct gtt ttc cat cag gag atg gtc       1691
Pro Pro Ile Ser Gly Ser Leu Thr Pro Val Phe His Gln Glu Met Val           
450                 455                 460                 465           

aac tat ttc ctg tcc ccg gcc ttc cgc tac cag cca gac ccc tgg aag       1739
Asn Tyr Phe Leu Ser Pro Ala Phe Arg Tyr Gln Pro Asp Pro Trp Lys           
                470                 475                 480               

ggg agt gcc gcc aag ggc acc ggc atc acc agg aag aag acc ttt aaa       1787
Gly Ser Ala Ala Lys Gly Thr Gly Ile Thr Arg Lys Lys Thr Phe Lys           
            485                 490                 495                   

gaa gtg gcc aac gcc gtg aag atc tcc gcc tcg ctc atg ggc acg gtg       1835
Glu Val Ala Asn Ala Val Lys Ile Ser Ala Ser Leu Met Gly Thr Val           
        500                 505                 510                       

atg gcg aag cga gtg aag gcg aca atc ctg tat ggc tcc gag acc ggc       1883
Met Ala Lys Arg Val Lys Ala Thr Ile Leu Tyr Gly Ser Glu Thr Gly           
    515                 520                 525                           

cgg gcc cag agc tac gca cag cag ctg ggg aga ctc ttc cgg aag gct       1931
Arg Ala Gln Ser Tyr Ala Gln Gln Leu Gly Arg Leu Phe Arg Lys Ala           
530                 535                 540                 545           

ttt gat ccc cgg gtc ctg tgt atg gat gag tat gac gtg gtg tcc ctc       1979
Phe Asp Pro Arg Val Leu Cys Met Asp Glu Tyr Asp Val Val Ser Leu           
                550                 555                 560               

gaa cac gag acg ctg gtg ctg gtg gta acc agc aca ttt ggg aat ggg       2027
Glu His Glu Thr Leu Val Leu Val Val Thr Ser Thr Phe Gly Asn Gly           
            565                 570                 575                   

gat ccc ccg gag aat gga gag agc ttt gca gct gcc ctg atg gag atg       2075
Asp Pro Pro Glu Asn Gly Glu Ser Phe Ala Ala Ala Leu Met Glu Met           
        580                 585                 590                       

tcc ggc ccc tac aac agc tcc cct cgg ccg gaa cag cac aag agt tat       2123
Ser Gly Pro Tyr Asn Ser Ser Pro Arg Pro Glu Gln His Lys Ser Tyr           
    595                 600                 605                           

aag atc cgc ttc aac agc atc tcc tgc tca gac cca ctg gtg tcc tct       2171
Lys Ile Arg Phe Asn Ser Ile Ser Cys Ser Asp Pro Leu Val Ser Ser           
610                 615                 620                 625           

tgg cgg cgg aag agg aag gag tcc agt aac aca gac agt gca ggg gcc       2219
Trp Arg Arg Lys Arg Lys Glu Ser Ser Asn Thr Asp Ser Ala Gly Ala           
                630                 635                 640               

ctg ggc acc ctc agg ttc tgt gtg ttc ggg ctc ggc tcc cgg gca tac       2267
Leu Gly Thr Leu Arg Phe Cys Val Phe Gly Leu Gly Ser Arg Ala Tyr           
            645                 650                 655                   

ccc cac ttc tgc gcc ttt gct cgt gcc gtg gac aca cgg ctg gag gaa       2315
Pro His Phe Cys Ala Phe Ala Arg Ala Val Asp Thr Arg Leu Glu Glu           
        660                 665                 670                       

ctg ggc ggg gag cgg ctg ctg cag ctg ggc cag ggc gac gag ctg tgc       2363
Leu Gly Gly Glu Arg Leu Leu Gln Leu Gly Gln Gly Asp Glu Leu Cys           
    675                 680                 685                           

ggc cag gag gag gcc ttc cga ggc tgg gcc cag gct gcc ttc cag gcc       2411
Gly Gln Glu Glu Ala Phe Arg Gly Trp Ala Gln Ala Ala Phe Gln Ala           
690                 695                 700                 705           

gcc tgt gag acc ttc tgt gtg gga gag gat gcc aag gcc gcc gcc cga       2459
Ala Cys Glu Thr Phe Cys Val Gly Glu Asp Ala Lys Ala Ala Ala Arg           
                710                 715                 720               

gac atc ttc agc ccc aaa cgg agc tgg aag cgc cag agg tac cgg ctg       2507
Asp Ile Phe Ser Pro Lys Arg Ser Trp Lys Arg Gln Arg Tyr Arg Leu           
            725                 730                 735                   

agc gcc cag gcc gag ggc ctg cag ttg ctg cca ggt ctg atc cac gtg       2555
Ser Ala Gln Ala Glu Gly Leu Gln Leu Leu Pro Gly Leu Ile His Val           
        740                 745                 750                       

cac agg cgg aag atg ttc cag gct aca atc cgc tca gtg gaa aac ctg       2603
His Arg Arg Lys Met Phe Gln Ala Thr Ile Arg Ser Val Glu Asn Leu           
    755                 760                 765                           

caa agc agc aag tcc acg agg gcc acc atc ctg gtg cgc ctg gac acc       2651
Gln Ser Ser Lys Ser Thr Arg Ala Thr Ile Leu Val Arg Leu Asp Thr           
770                 775                 780                 785           

gga ggc cag gag ggg ctg cag tac cag ccg ggg gac cac ata ggt gtc       2699
Gly Gly Gln Glu Gly Leu Gln Tyr Gln Pro Gly Asp His Ile Gly Val           
                790                 795                 800               

tgc ccg ccc aac cgg ccc ggc ctt gtg gag gcg ctg ctg agc cgc gtg       2747
Cys Pro Pro Asn Arg Pro Gly Leu Val Glu Ala Leu Leu Ser Arg Val           
            805                 810                 815                   

gag gac ccg ccg gcg ccc act gag ccc gtg gca gta gag cag ctg gag       2795
Glu Asp Pro Pro Ala Pro Thr Glu Pro Val Ala Val Glu Gln Leu Glu           
        820                 825                 830                       

aag ggc agc cct ggt ggc cct ccc ccc ggc tgg gtg cgg gac ccc cgg       2843
Lys Gly Ser Pro Gly Gly Pro Pro Pro Gly Trp Val Arg Asp Pro Arg           
    835                 840                 845                           

ctg ccc ccg tgc acg ctg cgc cag gct ctc acc ttc ttc ctg gac atc       2891
Leu Pro Pro Cys Thr Leu Arg Gln Ala Leu Thr Phe Phe Leu Asp Ile           
850                 855                 860                 865           

acc tcc cca ccc agc cct cag ctc ttg cgg ctg ctc agc acc ttg gca       2939
Thr Ser Pro Pro Ser Pro Gln Leu Leu Arg Leu Leu Ser Thr Leu Ala           
                870                 875                 880               

gaa gag ccc agg gaa cag cag gag ctg gag gcc ctc agc cag gat ccc       2987
Glu Glu Pro Arg Glu Gln Gln Glu Leu Glu Ala Leu Ser Gln Asp Pro           
            885                 890                 895                   

cga cgc tac gag gag tgg aag tgg ttc cgc tgc ccc acg ctg ctg gag       3035
Arg Arg Tyr Glu Glu Trp Lys Trp Phe Arg Cys Pro Thr Leu Leu Glu           
        900                 905                 910                       

gtg ctg gag cag ttc ccg tcg gtg gcg ctg cct gcc cca ctg ctc ctc       3083
Val Leu Glu Gln Phe Pro Ser Val Ala Leu Pro Ala Pro Leu Leu Leu           
    915                 920                 925                           

acc cag ctg cct ctg ctc cag ccc cgg tac tac tca gtc agc tcg gca       3131
Thr Gln Leu Pro Leu Leu Gln Pro Arg Tyr Tyr Ser Val Ser Ser Ala           
930                 935                 940                 945           

ccc agc acc cac cca gga gag atc cac ctc act gta gct gtg ctg gca       3179
Pro Ser Thr His Pro Gly Glu Ile His Leu Thr Val Ala Val Leu Ala           
                950                 955                 960               

tac agg act cag gat ggg ctg ggc ccc ctg cac tat gga gtc tgc tcc       3227
Tyr Arg Thr Gln Asp Gly Leu Gly Pro Leu His Tyr Gly Val Cys Ser           
            965                 970                 975                   

acg tgg cta agc cag ctc aag ccc gga gac cct gtg ccc tgc ttc atc       3275
Thr Trp Leu Ser Gln Leu Lys Pro Gly Asp Pro Val Pro Cys Phe Ile           
        980                 985                 990                       

cgg ggg gct ccc tcc ttc cgg  ctg cca ccc gat ccc  agc ttg ccc tgc     3323
Arg Gly Ala Pro Ser Phe Arg  Leu Pro Pro Asp Pro  Ser Leu Pro Cys         
    995                 1000                 1005                         

atc  ctg gtg ggt cca ggc  act ggc att gcc ccc  ttc cgg gga ttc        3368
Ile  Leu Val Gly Pro Gly  Thr Gly Ile Ala Pro  Phe Arg Gly Phe            
1010                 1015                 1020                            

tgg  cag gag cgg ctg cat  gac att gag agc aaa  ggg ctg cag ccc        3413
Trp  Gln Glu Arg Leu His  Asp Ile Glu Ser Lys  Gly Leu Gln Pro            
1025                 1030                 1035                            

act  ccc atg act ttg gtg  ttc ggc tgc cga tgc  tcc caa ctt gac        3458
Thr  Pro Met Thr Leu Val  Phe Gly Cys Arg Cys  Ser Gln Leu Asp            
1040                 1045                 1050                            

cat  ctc tac cgc gac gag  gtg cag aac gcc cag  cag cgc ggg gtg        3503
His  Leu Tyr Arg Asp Glu  Val Gln Asn Ala Gln  Gln Arg Gly Val            
1055                 1060                 1065                            

ttt  ggc cga gtc ctc acc  gcc ttc tcc cgg gaa  cct gac aac ccc        3548
Phe  Gly Arg Val Leu Thr  Ala Phe Ser Arg Glu  Pro Asp Asn Pro            
1070                 1075                 1080                            

aag  acc tac gtg cag gac  atc ctg agg acg gag  ctg gct gcg gag        3593
Lys  Thr Tyr Val Gln Asp  Ile Leu Arg Thr Glu  Leu Ala Ala Glu            
1085                 1090                 1095                            

gtg  cac cgc gtg ctg tgc  ctc gag cgg ggc cac  atg ttt gtc tgc        3638
Val  His Arg Val Leu Cys  Leu Glu Arg Gly His  Met Phe Val Cys            
1100                 1105                 1110                            

ggc  gat gtt acc atg gca  acc aac gtc ctg cag  acc gtg cag cgc        3683
Gly  Asp Val Thr Met Ala  Thr Asn Val Leu Gln  Thr Val Gln Arg            
1115                 1120                 1125                            

atc  ctg gcg acg gag ggc  gac atg gag ctg gac  gag gcc ggc gac        3728
Ile  Leu Ala Thr Glu Gly  Asp Met Glu Leu Asp  Glu Ala Gly Asp            
1130                 1135                 1140                            

gtc  atc ggc gtg ctg cgg  gat cag caa cgc tac  cac gaa gac att        3773
Val  Ile Gly Val Leu Arg  Asp Gln Gln Arg Tyr  His Glu Asp Ile            
1145                 1150                 1155                            

ttc  ggg ctc acg ctg cgc  acc cag gag gtg aca  agc cgc ata cgc        3818
Phe  Gly Leu Thr Leu Arg  Thr Gln Glu Val Thr  Ser Arg Ile Arg            
1160                 1165                 1170                            

acc  cag agc ttt tcc ttg  cag gag cgt cag ttg  cgg ggc gca gtg        3863
Thr  Gln Ser Phe Ser Leu  Gln Glu Arg Gln Leu  Arg Gly Ala Val            
1175                 1180                 1185                            

ccc  tgg gcg ttc gac cct  ccc ggc tca gac acc  aac agc ccc tga        3908
Pro  Trp Ala Phe Asp Pro  Pro Gly Ser Asp Thr  Asn Ser Pro                
1190                 1195                 1200                            

gagccgcctg gctttccctt ccagttccgg gagagcggct gcccgactca ggtccgcccg     3968

accaggatca gccccgctcc tcccctcttg aggtggtgcc ttctcacatc tgtccagagg     4028

ctgcaaggat tcagcattat tcctccagga aggagcaaaa cgcctctttt ccctctctag     4088

gcctgttgcc tcgggcctgg gtccgcctta atctggaagg cccctcccag cagcggtacc     4148

ccagggccta ctgccacccg cttcctgttt cttagtcgaa tgttagattc ctcttgcctc     4208

tctcaggagt atcttacctg taaagtctaa tctctaaatc aagtatttat tattgaagat     4268

ttaccataag ggactgtgcc agatgttagg agaactacta aagtgcctac cccagctcat     4328

gtggattaca aaaaaaa                                                    4345


<210>  4
<211>  1203
<212>  PRT
<213>  Homo sapiens

<400>  4

Met Gly Asn Leu Lys Ser Val Ala Gln Glu Pro Gly Pro Pro Cys Gly 
1               5                   10                  15      


Leu Gly Leu Gly Leu Gly Leu Gly Leu Cys Gly Lys Gln Gly Pro Ala 
            20                  25                  30          


Thr Pro Ala Pro Glu Pro Ser Arg Ala Pro Ala Ser Leu Leu Pro Pro 
        35                  40                  45              


Ala Pro Glu His Ser Pro Pro Ser Ser Pro Leu Thr Gln Pro Pro Glu 
    50                  55                  60                  


Gly Pro Lys Phe Pro Arg Val Lys Asn Trp Glu Val Gly Ser Ile Thr 
65                  70                  75                  80  


Tyr Asp Thr Leu Ser Ala Gln Ala Gln Gln Asp Gly Pro Cys Thr Pro 
                85                  90                  95      


Arg Arg Cys Leu Gly Ser Leu Val Phe Pro Arg Lys Leu Gln Gly Arg 
            100                 105                 110         


Pro Ser Pro Gly Pro Pro Ala Pro Glu Gln Leu Leu Ser Gln Ala Arg 
        115                 120                 125             


Asp Phe Ile Asn Gln Tyr Tyr Ser Ser Ile Lys Arg Ser Gly Ser Gln 
    130                 135                 140                 


Ala His Glu Gln Arg Leu Gln Glu Val Glu Ala Glu Val Ala Ala Thr 
145                 150                 155                 160 


Gly Thr Tyr Gln Leu Arg Glu Ser Glu Leu Val Phe Gly Ala Lys Gln 
                165                 170                 175     


Ala Trp Arg Asn Ala Pro Arg Cys Val Gly Arg Ile Gln Trp Gly Lys 
            180                 185                 190         


Leu Gln Val Phe Asp Ala Arg Asp Cys Arg Ser Ala Gln Glu Met Phe 
        195                 200                 205             


Thr Tyr Ile Cys Asn His Ile Lys Tyr Ala Thr Asn Arg Gly Asn Leu 
    210                 215                 220                 


Arg Ser Ala Ile Thr Val Phe Pro Gln Arg Cys Pro Gly Arg Gly Asp 
225                 230                 235                 240 


Phe Arg Ile Trp Asn Ser Gln Leu Val Arg Tyr Ala Gly Tyr Arg Gln 
                245                 250                 255     


Gln Asp Gly Ser Val Arg Gly Asp Pro Ala Asn Val Glu Ile Thr Glu 
            260                 265                 270         


Leu Cys Ile Gln His Gly Trp Thr Pro Gly Asn Gly Arg Phe Asp Val 
        275                 280                 285             


Leu Pro Leu Leu Leu Gln Ala Pro Asp Asp Pro Pro Glu Leu Phe Leu 
    290                 295                 300                 


Leu Pro Pro Glu Leu Val Leu Glu Val Pro Leu Glu His Pro Thr Leu 
305                 310                 315                 320 


Glu Trp Phe Ala Ala Leu Gly Leu Arg Trp Tyr Ala Leu Pro Ala Val 
                325                 330                 335     


Ser Asn Met Leu Leu Glu Ile Gly Gly Leu Glu Phe Pro Ala Ala Pro 
            340                 345                 350         


Phe Ser Gly Trp Tyr Met Ser Thr Glu Ile Gly Thr Arg Asn Leu Cys 
        355                 360                 365             


Asp Pro His Arg Tyr Asn Ile Leu Glu Asp Val Ala Val Cys Met Asp 
    370                 375                 380                 


Leu Asp Thr Arg Thr Thr Ser Ser Leu Trp Lys Asp Lys Ala Ala Val 
385                 390                 395                 400 


Glu Ile Asn Val Ala Val Leu His Ser Tyr Gln Leu Ala Lys Val Thr 
                405                 410                 415     


Ile Val Asp His His Ala Ala Thr Ala Ser Phe Met Lys His Leu Glu 
            420                 425                 430         


Asn Glu Gln Lys Ala Arg Gly Gly Cys Pro Ala Asp Trp Ala Trp Ile 
        435                 440                 445             


Val Pro Pro Ile Ser Gly Ser Leu Thr Pro Val Phe His Gln Glu Met 
    450                 455                 460                 


Val Asn Tyr Phe Leu Ser Pro Ala Phe Arg Tyr Gln Pro Asp Pro Trp 
465                 470                 475                 480 


Lys Gly Ser Ala Ala Lys Gly Thr Gly Ile Thr Arg Lys Lys Thr Phe 
                485                 490                 495     


Lys Glu Val Ala Asn Ala Val Lys Ile Ser Ala Ser Leu Met Gly Thr 
            500                 505                 510         


Val Met Ala Lys Arg Val Lys Ala Thr Ile Leu Tyr Gly Ser Glu Thr 
        515                 520                 525             


Gly Arg Ala Gln Ser Tyr Ala Gln Gln Leu Gly Arg Leu Phe Arg Lys 
    530                 535                 540                 


Ala Phe Asp Pro Arg Val Leu Cys Met Asp Glu Tyr Asp Val Val Ser 
545                 550                 555                 560 


Leu Glu His Glu Thr Leu Val Leu Val Val Thr Ser Thr Phe Gly Asn 
                565                 570                 575     


Gly Asp Pro Pro Glu Asn Gly Glu Ser Phe Ala Ala Ala Leu Met Glu 
            580                 585                 590         


Met Ser Gly Pro Tyr Asn Ser Ser Pro Arg Pro Glu Gln His Lys Ser 
        595                 600                 605             


Tyr Lys Ile Arg Phe Asn Ser Ile Ser Cys Ser Asp Pro Leu Val Ser 
    610                 615                 620                 


Ser Trp Arg Arg Lys Arg Lys Glu Ser Ser Asn Thr Asp Ser Ala Gly 
625                 630                 635                 640 


Ala Leu Gly Thr Leu Arg Phe Cys Val Phe Gly Leu Gly Ser Arg Ala 
                645                 650                 655     


Tyr Pro His Phe Cys Ala Phe Ala Arg Ala Val Asp Thr Arg Leu Glu 
            660                 665                 670         


Glu Leu Gly Gly Glu Arg Leu Leu Gln Leu Gly Gln Gly Asp Glu Leu 
        675                 680                 685             


Cys Gly Gln Glu Glu Ala Phe Arg Gly Trp Ala Gln Ala Ala Phe Gln 
    690                 695                 700                 


Ala Ala Cys Glu Thr Phe Cys Val Gly Glu Asp Ala Lys Ala Ala Ala 
705                 710                 715                 720 


Arg Asp Ile Phe Ser Pro Lys Arg Ser Trp Lys Arg Gln Arg Tyr Arg 
                725                 730                 735     


Leu Ser Ala Gln Ala Glu Gly Leu Gln Leu Leu Pro Gly Leu Ile His 
            740                 745                 750         


Val His Arg Arg Lys Met Phe Gln Ala Thr Ile Arg Ser Val Glu Asn 
        755                 760                 765             


Leu Gln Ser Ser Lys Ser Thr Arg Ala Thr Ile Leu Val Arg Leu Asp 
    770                 775                 780                 


Thr Gly Gly Gln Glu Gly Leu Gln Tyr Gln Pro Gly Asp His Ile Gly 
785                 790                 795                 800 


Val Cys Pro Pro Asn Arg Pro Gly Leu Val Glu Ala Leu Leu Ser Arg 
                805                 810                 815     


Val Glu Asp Pro Pro Ala Pro Thr Glu Pro Val Ala Val Glu Gln Leu 
            820                 825                 830         


Glu Lys Gly Ser Pro Gly Gly Pro Pro Pro Gly Trp Val Arg Asp Pro 
        835                 840                 845             


Arg Leu Pro Pro Cys Thr Leu Arg Gln Ala Leu Thr Phe Phe Leu Asp 
    850                 855                 860                 


Ile Thr Ser Pro Pro Ser Pro Gln Leu Leu Arg Leu Leu Ser Thr Leu 
865                 870                 875                 880 


Ala Glu Glu Pro Arg Glu Gln Gln Glu Leu Glu Ala Leu Ser Gln Asp 
                885                 890                 895     


Pro Arg Arg Tyr Glu Glu Trp Lys Trp Phe Arg Cys Pro Thr Leu Leu 
            900                 905                 910         


Glu Val Leu Glu Gln Phe Pro Ser Val Ala Leu Pro Ala Pro Leu Leu 
        915                 920                 925             


Leu Thr Gln Leu Pro Leu Leu Gln Pro Arg Tyr Tyr Ser Val Ser Ser 
    930                 935                 940                 


Ala Pro Ser Thr His Pro Gly Glu Ile His Leu Thr Val Ala Val Leu 
945                 950                 955                 960 


Ala Tyr Arg Thr Gln Asp Gly Leu Gly Pro Leu His Tyr Gly Val Cys 
                965                 970                 975     


Ser Thr Trp Leu Ser Gln Leu Lys Pro Gly Asp Pro Val Pro Cys Phe 
            980                 985                 990         


Ile Arg Gly Ala Pro Ser Phe Arg  Leu Pro Pro Asp Pro  Ser Leu Pro 
        995                 1000                 1005             


Cys Ile  Leu Val Gly Pro Gly  Thr Gly Ile Ala Pro  Phe Arg Gly 
    1010                 1015                 1020             


Phe Trp  Gln Glu Arg Leu His  Asp Ile Glu Ser Lys  Gly Leu Gln 
    1025                 1030                 1035             


Pro Thr  Pro Met Thr Leu Val  Phe Gly Cys Arg Cys  Ser Gln Leu 
    1040                 1045                 1050             


Asp His  Leu Tyr Arg Asp Glu  Val Gln Asn Ala Gln  Gln Arg Gly 
    1055                 1060                 1065             


Val Phe  Gly Arg Val Leu Thr  Ala Phe Ser Arg Glu  Pro Asp Asn 
    1070                 1075                 1080             


Pro Lys  Thr Tyr Val Gln Asp  Ile Leu Arg Thr Glu  Leu Ala Ala 
    1085                 1090                 1095             


Glu Val  His Arg Val Leu Cys  Leu Glu Arg Gly His  Met Phe Val 
    1100                 1105                 1110             


Cys Gly  Asp Val Thr Met Ala  Thr Asn Val Leu Gln  Thr Val Gln 
    1115                 1120                 1125             


Arg Ile  Leu Ala Thr Glu Gly  Asp Met Glu Leu Asp  Glu Ala Gly 
    1130                 1135                 1140             


Asp Val  Ile Gly Val Leu Arg  Asp Gln Gln Arg Tyr  His Glu Asp 
    1145                 1150                 1155             


Ile Phe  Gly Leu Thr Leu Arg  Thr Gln Glu Val Thr  Ser Arg Ile 
    1160                 1165                 1170             


Arg Thr  Gln Ser Phe Ser Leu  Gln Glu Arg Gln Leu  Arg Gly Ala 
    1175                 1180                 1185             


Val Pro  Trp Ala Phe Asp Pro  Pro Gly Ser Asp Thr  Asn Ser Pro 
    1190                 1195                 1200             


<210>  5
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic primer

<400>  5
aaggcaggag acagtggatg ga                                                22


<210>  6
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic primer

<400>  6
cccagtcaat ccctttggtg ctca                                              24


<210>  7
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic primer

<400>  7
tggagagtgc tggtgtaccc ca                                                22


<210>  8
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic primer

<400>  8
gcctccaccc ccaccctgtc                                                   20


<210>  9
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic primer

<400>  9
aggccctatg gtagtgcctt t                                                 21


<210>  10
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic primer

<400>  10
tctcttagtg ctgtggtcac                                                   20


