                         SEQUENCE LISTING

<110>  CSIR
 
<120>  Inhibition of the activity of kinase and sythetase enzymes

<130>  P46592ZA00

<150>  2009/09160
<151>  2009-12-22

<160>  59    

<170>  PatentIn version 3.5

<210>  1
<211>  194
<212>  PRT
<213>  Homo sapiens

<400>  1

Met Glu Glu Lys Leu Lys Lys Thr Lys Ile Ile Phe Val Val Gly Gly 
1               5                   10                  15      


Pro Gly Ser Gly Lys Gly Thr Gln Cys Glu Lys Ile Val Gln Lys Tyr 
            20                  25                  30          


Gly Tyr Thr His Leu Ser Thr Gly Asp Leu Leu Arg Ser Glu Val Ser 
        35                  40                  45              


Ser Gly Ser Ala Arg Gly Lys Lys Leu Ser Glu Ile Met Glu Lys Gly 
    50                  55                  60                  


Gln Leu Val Pro Leu Glu Thr Val Leu Asp Met Leu Arg Asp Ala Met 
65                  70                  75                  80  


Val Ala Lys Val Asn Thr Ser Lys Gly Phe Leu Ile Asp Gly Tyr Pro 
                85                  90                  95      


Arg Glu Val Gln Gln Gly Glu Glu Phe Glu Arg Arg Ile Gly Gln Pro 
            100                 105                 110         


Thr Leu Leu Leu Tyr Val Asp Ala Gly Pro Glu Thr Met Thr Gln Arg 
        115                 120                 125             


Leu Leu Lys Arg Gly Glu Thr Ser Gly Arg Val Asp Asp Asn Glu Glu 
    130                 135                 140                 


Thr Ile Lys Lys Arg Leu Glu Thr Tyr Tyr Lys Ala Thr Glu Pro Val 
145                 150                 155                 160 


Ile Ala Phe Tyr Glu Lys Arg Gly Ile Val Arg Lys Val Asn Ala Glu 
                165                 170                 175     


Gly Ser Val Asp Ser Val Phe Ser Gln Val Cys Thr His Leu Asp Ala 
            180                 185                 190         


Leu Lys 
        


<210>  2
<211>  239
<212>  PRT
<213>  Homo sapiens

<400>  2

Met Ala Pro Ser Val Pro Ala Ala Glu Pro Glu Tyr Pro Lys Gly Ile 
1               5                   10                  15      


Arg Ala Val Leu Leu Gly Pro Pro Gly Ala Gly Lys Gly Thr Gln Ala 
            20                  25                  30          


Pro Arg Leu Ala Glu Asn Phe Cys Val Cys His Leu Ala Thr Gly Asp 
        35                  40                  45              


Met Leu Arg Ala Met Val Ala Ser Gly Ser Glu Leu Gly Lys Lys Leu 
    50                  55                  60                  


Lys Ala Thr Met Asp Ala Gly Lys Leu Val Ser Asp Glu Met Val Val 
65                  70                  75                  80  


Glu Leu Ile Glu Lys Asn Leu Glu Thr Pro Leu Cys Lys Asn Gly Phe 
                85                  90                  95      


Leu Leu Asp Gly Phe Pro Arg Thr Val Arg Gln Ala Glu Met Leu Asp 
            100                 105                 110         


Asp Leu Met Glu Lys Arg Lys Glu Lys Leu Asp Ser Val Ile Glu Phe 
        115                 120                 125             


Ser Ile Pro Asp Ser Leu Leu Ile Arg Arg Ile Thr Gly Arg Leu Ile 
    130                 135                 140                 


His Pro Lys Ser Gly Arg Ser Tyr His Glu Glu Phe Asn Pro Pro Lys 
145                 150                 155                 160 


Glu Pro Met Lys Asp Asp Ile Thr Gly Glu Pro Leu Ile Arg Arg Ser 
                165                 170                 175     


Asp Asp Asn Glu Lys Ala Leu Lys Ile Arg Leu Gln Ala Tyr His Thr 
            180                 185                 190         


Gln Thr Thr Pro Leu Ile Glu Tyr Tyr Arg Lys Arg Gly Ile His Ser 
        195                 200                 205             


Ala Ile Asp Ala Ser Gln Thr Pro Asp Val Val Phe Ala Ser Ile Leu 
    210                 215                 220                 


Ala Ala Phe Ser Lys Ala Thr Cys Lys Asp Leu Val Met Phe Ile 
225                 230                 235                 


<210>  3
<211>  227
<212>  PRT
<213>  Homo sapiens

<400>  3

Met Gly Ala Ser Ala Arg Leu Leu Arg Ala Val Ile Met Gly Ala Pro 
1               5                   10                  15      


Gly Ser Gly Lys Gly Thr Val Ser Ser Arg Ile Thr Thr His Phe Glu 
            20                  25                  30          


Leu Lys His Leu Ser Ser Gly Asp Leu Leu Arg Asp Asn Met Leu Arg 
        35                  40                  45              


Gly Thr Glu Ile Gly Val Leu Ala Lys Ala Phe Ile Asp Gln Gly Lys 
    50                  55                  60                  


Leu Ile Pro Asp Asp Val Met Thr Arg Leu Ala Leu His Glu Leu Lys 
65                  70                  75                  80  


Asn Leu Thr Gln Tyr Ser Trp Leu Leu Asp Gly Phe Pro Arg Thr Leu 
                85                  90                  95      


Pro Gln Ala Glu Ala Leu Asp Arg Ala Tyr Gln Ile Asp Thr Val Ile 
            100                 105                 110         


Asn Leu Asn Val Pro Phe Glu Val Ile Lys Gln Arg Leu Thr Ala Arg 
        115                 120                 125             


Trp Ile His Pro Ala Ser Gly Arg Val Tyr Asn Ile Glu Phe Asn Pro 
    130                 135                 140                 


Pro Lys Thr Val Gly Ile Asp Asp Leu Thr Gly Glu Pro Leu Ile Gln 
145                 150                 155                 160 


Arg Glu Asp Asp Lys Pro Glu Thr Val Ile Lys Arg Leu Lys Ala Tyr 
                165                 170                 175     


Glu Asp Gln Thr Lys Pro Val Leu Glu Tyr Tyr Gln Lys Lys Gly Val 
            180                 185                 190         


Leu Glu Thr Phe Ser Gly Thr Glu Thr Asn Lys Ile Trp Pro Tyr Val 
        195                 200                 205             


Tyr Ala Phe Leu Gln Thr Lys Val Pro Gln Arg Ser Gln Lys Ala Ser 
    210                 215                 220                 


Val Thr Pro 
225         


<210>  4
<211>  223
<212>  PRT
<213>  Homo sapiens

<400>  4

Met Ala Ser Lys Leu Leu Arg Ala Val Ile Leu Gly Pro Pro Gly Ser 
1               5                   10                  15      


Gly Lys Gly Thr Val Cys Gln Arg Ile Ala Gln Asn Phe Gly Leu Gln 
            20                  25                  30          


His Leu Ser Ser Gly His Phe Leu Arg Glu Asn Ile Lys Ala Ser Thr 
        35                  40                  45              


Glu Val Gly Glu Met Ala Lys Gln Tyr Ile Glu Lys Ser Leu Leu Val 
    50                  55                  60                  


Pro Asp His Val Ile Thr Arg Leu Met Met Ser Glu Leu Glu Asn Arg 
65                  70                  75                  80  


Arg Gly Gln His Trp Leu Leu Asp Gly Phe Pro Arg Thr Leu Gly Gln 
                85                  90                  95      


Ala Glu Ala Leu Asp Lys Ile Cys Glu Val Asp Leu Val Ile Ser Leu 
            100                 105                 110         


Asn Ile Pro Phe Glu Thr Leu Lys Asp Arg Leu Ser Arg Arg Trp Ile 
        115                 120                 125             


His Pro Pro Ser Gly Arg Val Tyr Asn Leu Asp Phe Asn Pro Pro His 
    130                 135                 140                 


Val His Gly Ile Asp Asp Val Thr Gly Glu Pro Leu Val Gln Gln Glu 
145                 150                 155                 160 


Asp Asp Lys Pro Glu Ala Val Ala Ala Arg Leu Arg Gln Tyr Lys Asp 
                165                 170                 175     


Val Ala Lys Pro Val Ile Glu Leu Tyr Lys Ser Arg Gly Val Leu His 
            180                 185                 190         


Gln Phe Ser Gly Thr Glu Thr Asn Lys Ile Trp Pro Tyr Val Tyr Thr 
        195                 200                 205             


Leu Phe Ser Asn Lys Ile Thr Pro Ile Gln Ser Lys Glu Ala Tyr 
    210                 215                 220             


<210>  5
<211>  198
<212>  PRT
<213>  Homo sapiens

<400>  5

Met Gly Gly Phe Met Glu Asp Leu Arg Lys Cys Lys Ile Ile Phe Ile 
1               5                   10                  15      


Ile Gly Gly Pro Gly Ser Gly Lys Gly Thr Gln Cys Glu Lys Leu Val 
            20                  25                  30          


Glu Lys Tyr Gly Phe Thr His Leu Ser Thr Gly Glu Leu Leu Arg Glu 
        35                  40                  45              


Glu Leu Ala Ser Glu Ser Glu Arg Ser Lys Leu Ile Arg Asp Ile Met 
    50                  55                  60                  


Glu Arg Gly Asp Leu Val Pro Ser Gly Ile Val Leu Glu Leu Leu Lys 
65                  70                  75                  80  


Glu Ala Met Val Ala Ser Leu Gly Asp Thr Arg Gly Phe Leu Ile Asp 
                85                  90                  95      


Gly Tyr Pro Arg Glu Val Lys Gln Gly Glu Glu Phe Gly Arg Arg Ile 
            100                 105                 110         


Gly Asp Pro Gln Leu Val Ile Cys Met Asp Cys Ser Ala Asp Thr Met 
        115                 120                 125             


Thr Asn Arg Leu Leu Gln Arg Ser Arg Ser Ser Leu Pro Val Asp Asp 
    130                 135                 140                 


Thr Thr Lys Thr Ile Ala Lys Arg Leu Glu Ala Tyr Tyr Arg Ala Ser 
145                 150                 155                 160 


Ile Pro Val Ile Ala Tyr Tyr Glu Thr Lys Thr Gln Leu His Lys Ile 
                165                 170                 175     


Asn Ala Glu Gly Thr Pro Glu Asp Val Phe Leu Gln Leu Cys Thr Ala 
            180                 185                 190         


Ile Asp Ser Ile Ile Phe 
        195             


<210>  6
<211>  172
<212>  PRT
<213>  Homo sapiens

<400>  6

Met Leu Leu Pro Asn Ile Leu Leu Thr Gly Thr Pro Gly Val Gly Lys 
1               5                   10                  15      


Thr Thr Leu Gly Lys Glu Leu Ala Ser Lys Ser Gly Leu Lys Tyr Ile 
            20                  25                  30          


Asn Val Gly Asp Leu Ala Arg Glu Glu Gln Leu Tyr Asp Gly Tyr Asp 
        35                  40                  45              


Glu Glu Tyr Asp Cys Pro Ile Leu Asp Glu Asp Arg Val Val Asp Glu 
    50                  55                  60                  


Leu Asp Asn Gln Met Arg Glu Gly Gly Val Ile Val Asp Tyr His Gly 
65                  70                  75                  80  


Cys Asp Phe Phe Pro Glu Arg Trp Phe His Ile Val Phe Val Leu Arg 
                85                  90                  95      


Thr Asp Thr Asn Val Leu Tyr Glu Arg Leu Glu Thr Arg Gly Tyr Asn 
            100                 105                 110         


Glu Lys Lys Leu Thr Asp Asn Ile Gln Cys Glu Ile Phe Gln Val Leu 
        115                 120                 125             


Tyr Glu Glu Ala Thr Ala Ser Tyr Lys Glu Glu Ile Val His Gln Leu 
    130                 135                 140                 


Pro Ser Asn Lys Pro Glu Glu Leu Glu Asn Asn Val Asp Gln Ile Leu 
145                 150                 155                 160 


Lys Trp Ile Glu Gln Trp Ile Lys Asp His Asn Ser 
                165                 170         


<210>  7
<211>  173
<212>  PRT
<213>  Escherichia coli

<400>  7

Met Ala Glu Lys Arg Asn Ile Phe Leu Val Gly Pro Met Gly Ala Gly 
1               5                   10                  15      


Lys Ser Thr Ile Gly Arg Gln Leu Ala Gln Gln Leu Asn Met Glu Phe 
            20                  25                  30          


Tyr Asp Ser Asp Gln Glu Ile Glu Lys Arg Thr Gly Ala Asp Val Gly 
        35                  40                  45              


Trp Val Phe Asp Leu Glu Gly Glu Glu Gly Phe Arg Asp Arg Glu Glu 
    50                  55                  60                  


Lys Val Ile Asn Glu Leu Thr Glu Lys Gln Gly Ile Val Leu Ala Thr 
65                  70                  75                  80  


Gly Gly Gly Ser Val Lys Ser Arg Glu Thr Arg Asn Arg Leu Ser Ala 
                85                  90                  95      


Arg Gly Val Val Val Tyr Leu Glu Thr Thr Ile Glu Lys Gln Leu Ala 
            100                 105                 110         


Arg Thr Gln Arg Asp Lys Lys Arg Pro Leu Leu His Val Glu Thr Pro 
        115                 120                 125             


Pro Arg Glu Val Leu Glu Ala Leu Ala Asn Glu Arg Asn Pro Leu Tyr 
    130                 135                 140                 


Glu Glu Ile Ala Asp Val Thr Ile Arg Thr Asp Asp Gln Ser Ala Lys 
145                 150                 155                 160 


Val Val Ala Asn Gln Ile Ile His Met Leu Glu Ser Asn 
                165                 170             


<210>  8
<211>  174
<212>  PRT
<213>  Escherichia coli

<400>  8

Met Thr Gln Pro Leu Phe Leu Ile Gly Pro Arg Gly Cys Gly Lys Thr 
1               5                   10                  15      


Thr Val Gly Met Ala Leu Ala Asp Ser Leu Asn Arg Arg Phe Val Asp 
            20                  25                  30          


Thr Asp Gln Trp Leu Gln Ser Gln Leu Asn Met Thr Val Ala Glu Ile 
        35                  40                  45              


Val Glu Arg Glu Glu Trp Ala Gly Phe Arg Ala Arg Glu Thr Ala Ala 
    50                  55                  60                  


Leu Glu Ala Val Thr Ala Pro Ser Thr Val Ile Ala Thr Gly Gly Gly 
65                  70                  75                  80  


Ile Ile Leu Thr Glu Phe Asn Arg His Phe Met Gln Asn Asn Gly Ile 
                85                  90                  95      


Val Val Tyr Leu Cys Ala Pro Val Ser Val Leu Val Asn Arg Leu Gln 
            100                 105                 110         


Ala Ala Pro Glu Glu Asp Leu Arg Pro Thr Leu Thr Gly Lys Pro Leu 
        115                 120                 125             


Ser Glu Glu Val Gln Glu Val Leu Glu Glu Arg Asp Ala Leu Tyr Arg 
    130                 135                 140                 


Glu Val Ala His Ile Ile Ile Asp Ala Thr Asn Glu Pro Ser Gln Val 
145                 150                 155                 160 


Ile Ser Glu Ile Arg Ser Ala Leu Ala Gln Thr Ile Asn Cys 
                165                 170                 


<210>  9
<211>  173
<212>  PRT
<213>  Klebsiella pneumoniae

<400>  9

Met Ala Glu Lys Arg Asn Ile Phe Leu Val Gly Pro Met Gly Ala Gly 
1               5                   10                  15      


Lys Ser Thr Ile Gly Arg Gln Leu Ala Gln Gln Leu Asn Met Glu Phe 
            20                  25                  30          


Tyr Asp Ser Asp Gln Glu Ile Glu Lys Arg Thr Gly Ala Asp Val Gly 
        35                  40                  45              


Trp Val Phe Asp Val Glu Gly Glu Glu Gly Phe Arg Asp Arg Glu Glu 
    50                  55                  60                  


Lys Ile Ile Asn Glu Leu Thr Glu Lys Gln Gly Ile Val Leu Ala Thr 
65                  70                  75                  80  


Gly Gly Gly Ser Val Lys Ser Arg Glu Thr Arg Asn Arg Leu Ser Ala 
                85                  90                  95      


Arg Gly Val Val Val Tyr Leu Glu Thr Thr Ile Glu Lys Gln Leu Ala 
            100                 105                 110         


Arg Thr Gln Arg Asp Lys Lys Arg Pro Leu Leu Gln Val Asp Ala Pro 
        115                 120                 125             


Pro Arg Glu Val Leu Glu Ala Leu Ala Asp Glu Arg Asn Pro Leu Tyr 
    130                 135                 140                 


Glu Glu Ile Ala Asp Val Thr Ile Arg Thr Asp Asp Gln Ser Ala Lys 
145                 150                 155                 160 


Val Val Ala Asn Gln Ile Ile His Met Leu Glu Ser Asn 
                165                 170             


<210>  10
<211>  177
<212>  PRT
<213>  Klebsiella pneumoniae

<400>  10

Met Thr Gln Pro Ile Phe Leu Ile Gly Pro Arg Gly Cys Gly Lys Thr 
1               5                   10                  15      


Thr Val Gly His Ala Leu Ala Arg Ala Arg His Phe Gln Phe Ser Asp 
            20                  25                  30          


Thr Asp His Arg Leu Gln Ala His Glu Gln Arg Thr Val Ala Glu Ile 
        35                  40                  45              


Val Gln Ala Glu Gly Trp Ala Arg Phe Arg Glu Leu Glu Thr Leu Ser 
    50                  55                  60                  


Leu Lys Ala Val Thr Leu Pro Asn Thr Val Ile Ala Thr Gly Gly Gly 
65                  70                  75                  80  


Ile Val Leu Ala Glu Gly Asn Arg Gln Phe Met Arg Glu Asn Gly Val 
                85                  90                  95      


Val Ile Tyr Leu Gln Ala Ser Val Ser Ala Leu Ile Asp Arg Leu Glu 
            100                 105                 110         


Ala Tyr Pro Lys Ala Glu Gln Arg Pro Thr Leu Thr Gly Lys Pro Val 
        115                 120                 125             


Arg Glu Glu Val Gly Glu Val Leu Ala Gln Arg Glu Ala Leu Tyr Arg 
    130                 135                 140                 


Asp Ala Ala His His Ile Val Asp Ala Thr Ala Ser Pro Asp Arg Val 
145                 150                 155                 160 


Val Glu Gln Ile Met Ser Met Leu Cys Ser Ala Thr Ala Thr Pro Val 
                165                 170                 175     


Ser 
    


<210>  11
<211>  173
<212>  PRT
<213>  Yersinia pestis

<400>  11

Met Ala Glu Lys Arg Asn Ile Phe Leu Val Gly Pro Met Gly Ala Gly 
1               5                   10                  15      


Lys Ser Thr Ile Gly Arg Gln Leu Ala Gln Gln Leu Asn Met Glu Phe 
            20                  25                  30          


Phe Asp Ser Asp Gln Glu Ile Glu Arg Arg Thr Gly Ala Asp Val Gly 
        35                  40                  45              


Trp Val Phe Asp Val Glu Gly Glu Glu Gly Phe Arg Asp Arg Glu Glu 
    50                  55                  60                  


Lys Val Ile Asn Glu Leu Thr Glu Lys Gln Gly Ile Val Leu Ala Thr 
65                  70                  75                  80  


Gly Gly Gly Ser Val Lys Ser Arg Glu Thr Arg Asn Arg Leu Ser Ala 
                85                  90                  95      


Arg Gly Val Val Val Tyr Leu Glu Thr Thr Ile Glu Lys Gln Leu Ala 
            100                 105                 110         


Arg Thr Gln Arg Asp Lys Lys Arg Pro Leu Leu Gln Val Asp Glu Pro 
        115                 120                 125             


Pro Arg Glu Val Leu Glu Ala Leu Ala Lys Glu Arg Asn Pro Leu Tyr 
    130                 135                 140                 


Glu Glu Ile Ala Asp Val Thr Ile Arg Thr Asp Asp Gln Ser Ala Lys 
145                 150                 155                 160 


Val Val Ala Asn Gln Ile Ile Asn Met Leu Glu Ser Asn 
                165                 170             


<210>  12
<211>  174
<212>  PRT
<213>  Yersinia pestis

<400>  12

Met Thr Gln Thr Ile Phe Met Val Gly Ala Arg Gly Ala Gly Lys Thr 
1               5                   10                  15      


Thr Ile Gly Lys Ala Leu Ala Gln Ala Leu Gly Tyr Arg Phe Val Asp 
            20                  25                  30          


Thr Asp Leu Phe Met Gln Gln Thr Ser Gln Met Thr Val Ala Glu Val 
        35                  40                  45              


Val Glu Ser Glu Gly Trp Asp Gly Phe Arg Leu Arg Glu Ser Met Ala 
    50                  55                  60                  


Leu Gln Ala Val Thr Ala Pro Lys Thr Val Val Ala Thr Gly Gly Gly 
65                  70                  75                  80  


Ala Val Leu Ser Ser Glu Asn Arg Ala Phe Met Arg Asp His Gly Arg 
                85                  90                  95      


Val Ile Tyr Leu Arg Ala Ser Ala Ala Val Leu Ala Lys Arg Leu Ala 
            100                 105                 110         


Glu Asp Pro Glu Glu Ala Gln Arg Pro Ser Leu Thr Gly Lys Pro Ile 
        115                 120                 125             


Val Glu Glu Ile Leu Asp Val Leu Ala Ser Arg Glu Ala Leu Tyr Gln 
    130                 135                 140                 


Asp Val Ala His His Val Leu Asp Gly Thr Gln Thr Pro Ser Leu Val 
145                 150                 155                 160 


Val Glu Gln Ile Leu Gln Met Leu Thr Gly Glu Met Val Lys 
                165                 170                 


<210>  13
<211>  173
<212>  PRT
<213>  Shigella flexneri

<400>  13

Met Ala Glu Lys Arg Asn Ile Phe Leu Val Gly Pro Met Gly Ala Gly 
1               5                   10                  15      


Lys Ser Thr Ile Gly Arg Gln Leu Ala Gln Gln Leu Asn Met Glu Phe 
            20                  25                  30          


Tyr Asp Ser Asp Gln Glu Ile Glu Lys Arg Thr Gly Ala Asp Val Gly 
        35                  40                  45              


Trp Val Phe Asp Leu Glu Gly Glu Glu Gly Phe Arg Asp Arg Glu Glu 
    50                  55                  60                  


Lys Val Ile Asn Glu Leu Thr Glu Lys Gln Gly Ile Val Leu Ala Thr 
65                  70                  75                  80  


Gly Gly Gly Ser Val Lys Ser Arg Glu Thr Arg Asn Arg Leu Ser Ala 
                85                  90                  95      


Arg Gly Val Val Val Tyr Leu Glu Thr Thr Ile Glu Lys Gln Leu Ala 
            100                 105                 110         


Arg Thr Gln Arg Asp Lys Lys Arg Pro Leu Leu His Val Glu Thr Pro 
        115                 120                 125             


Pro Arg Glu Val Leu Glu Ala Leu Ala Asn Glu Arg Asn Pro Leu Tyr 
    130                 135                 140                 


Glu Glu Ile Ala Asp Val Thr Ile Arg Thr Asp Asp Gln Ser Ala Lys 
145                 150                 155                 160 


Val Val Ala Asn Gln Ile Ile His Met Leu Glu Ser Asn 
                165                 170             


<210>  14
<211>  174
<212>  PRT
<213>  Shigella flexneri

<400>  14

Met Thr Gln Pro Leu Phe Leu Ile Gly Pro Arg Gly Cys Gly Lys Thr 
1               5                   10                  15      


Thr Val Gly Met Ala Leu Ala Asp Ser Leu Asn Arg Arg Phe Val Asp 
            20                  25                  30          


Thr Asp Gln Trp Leu Gln Ser Gln Leu Asn Met Thr Val Ala Glu Ile 
        35                  40                  45              


Val Glu Arg Glu Glu Trp Ala Gly Phe Arg Ala Arg Glu Thr Ala Ala 
    50                  55                  60                  


Leu Glu Ala Val Thr Ala Ala Ser Thr Val Ile Ala Thr Gly Gly Gly 
65                  70                  75                  80  


Ile Ile Leu Thr Glu Phe Asn Arg His Phe Met Gln Asn Asn Gly Ile 
                85                  90                  95      


Val Val Tyr Leu Cys Ala Pro Val Ser Val Leu Val Asn Arg Leu Gln 
            100                 105                 110         


Ala Ala Pro Glu Glu Asp Leu Arg Pro Thr Leu Thr Gly Lys Pro Leu 
        115                 120                 125             


Ser Glu Glu Val Gln Glu Val Leu Glu Glu Arg Asp Ala Leu Tyr Arg 
    130                 135                 140                 


Glu Val Ala His Ile Ile Ile Asp Ala Thr Asn Glu Pro Ser Gln Val 
145                 150                 155                 160 


Ile Ser Glu Ile Arg Ser Ala Leu Ala Gln Thr Ile Asn Cys 
                165                 170                 


<210>  15
<211>  176
<212>  PRT
<213>  Mycobacterium tuberculosis

<400>  15

Met Ala Pro Lys Ala Val Leu Val Gly Leu Pro Gly Ser Gly Lys Ser 
1               5                   10                  15      


Thr Ile Gly Arg Arg Leu Ala Lys Ala Leu Gly Val Gly Leu Leu Asp 
            20                  25                  30          


Thr Asp Val Ala Ile Glu Gln Arg Thr Gly Arg Ser Ile Ala Asp Ile 
        35                  40                  45              


Phe Ala Thr Asp Gly Glu Gln Glu Phe Arg Arg Ile Glu Glu Asp Val 
    50                  55                  60                  


Val Arg Ala Ala Leu Ala Asp His Asp Gly Val Leu Ser Leu Gly Gly 
65                  70                  75                  80  


Gly Ala Val Thr Ser Pro Gly Val Arg Ala Ala Leu Ala Gly His Thr 
                85                  90                  95      


Val Val Tyr Leu Glu Ile Ser Ala Ala Glu Gly Val Arg Arg Thr Gly 
            100                 105                 110         


Gly Asn Thr Val Arg Pro Leu Leu Ala Gly Pro Asp Arg Ala Glu Lys 
        115                 120                 125             


Tyr Arg Ala Leu Met Ala Lys Arg Ala Pro Leu Tyr Arg Arg Val Ala 
    130                 135                 140                 


Thr Met Arg Val Asp Thr Asn Arg Arg Asn Pro Gly Ala Val Val Arg 
145                 150                 155                 160 


His Ile Leu Ser Arg Leu Gln Val Pro Ser Pro Ser Glu Ala Ala Thr 
                165                 170                 175     


<210>  16
<211>  574
<212>  PRT
<213>  Rattus Norvegicus

<400>  16

Met Ser Val Gln Glu Asn Thr Leu Pro Gln Gln Leu Trp Pro Trp Ile 
1               5                   10                  15      


Phe Arg Ser Gln Lys Asp Leu Ala Lys Ser Ala Leu Ser Gly Ala Pro 
            20                  25                  30          


Gly Gly Pro Ala Gly Tyr Leu Arg Arg Ala Ser Val Ala Gln Leu Thr 
        35                  40                  45              


Gln Glu Leu Gly Thr Ala Phe Phe Gln Gln Gln Gln Leu Pro Ala Ala 
    50                  55                  60                  


Met Ala Asp Thr Phe Leu Glu His Leu Cys Leu Leu Asp Ile Asp Ser 
65                  70                  75                  80  


Gln Pro Val Ala Ala Arg Ser Thr Ser Ile Ile Ala Thr Ile Gly Pro 
                85                  90                  95      


Ala Ser Arg Ser Val Asp Arg Leu Lys Glu Met Ile Lys Ala Gly Met 
            100                 105                 110         


Asn Ile Ala Arg Leu Asn Phe Ser His Gly Ser His Glu Tyr His Ala 
        115                 120                 125             


Glu Ser Ile Ala Asn Ile Arg Glu Ala Thr Glu Ser Phe Ala Thr Ser 
    130                 135                 140                 


Pro Leu Ser Tyr Arg Pro Val Ala Ile Ala Leu Asp Thr Lys Gly Pro 
145                 150                 155                 160 


Glu Ile Arg Thr Gly Val Leu Gln Gly Gly Pro Glu Ser Glu Val Glu 
                165                 170                 175     


Ile Val Lys Gly Ser Gln Val Leu Val Thr Val Asp Pro Lys Phe Gln 
            180                 185                 190         


Thr Arg Gly Asp Ala Lys Thr Val Trp Val Asp Tyr His Asn Ile Thr 
        195                 200                 205             


Arg Val Val Ala Val Gly Gly Arg Ile Tyr Ile Asp Asp Gly Leu Ile 
    210                 215                 220                 


Ser Leu Val Val Gln Lys Ile Gly Pro Glu Gly Leu Val Thr Glu Val 
225                 230                 235                 240 


Glu His Gly Gly Ile Leu Gly Ser Arg Lys Gly Val Asn Leu Pro Asn 
                245                 250                 255     


Thr Glu Val Asp Leu Pro Gly Leu Ser Glu Gln Asp Leu Leu Asp Leu 
            260                 265                 270         


Arg Phe Gly Val Gln His Asn Val Asp Ile Ile Phe Ala Ser Phe Val 
        275                 280                 285             


Arg Lys Ala Ser Asp Val Leu Ala Val Arg Asp Ala Leu Gly Pro Glu 
    290                 295                 300                 


Gly Gln Asn Ile Lys Ile Ile Ser Lys Ile Glu Asn His Glu Gly Val 
305                 310                 315                 320 


Lys Lys Phe Asp Glu Ile Leu Glu Val Ser Asp Gly Ile Met Val Ala 
                325                 330                 335     


Arg Gly Asp Leu Gly Ile Glu Ile Pro Ala Glu Lys Val Phe Leu Ala 
            340                 345                 350         


Gln Lys Met Met Ile Gly Arg Cys Asn Leu Ala Gly Lys Pro Val Val 
        355                 360                 365             


Cys Ala Thr Gln Met Leu Glu Ser Met Ile Thr Lys Ala Arg Pro Thr 
    370                 375                 380                 


Arg Ala Glu Thr Ser Asp Val Ala Asn Ala Val Leu Asp Gly Ala Asp 
385                 390                 395                 400 


Cys Ile Met Leu Ser Gly Glu Thr Ala Lys Gly Ser Phe Pro Val Glu 
                405                 410                 415     


Ala Val Met Met Gln His Ala Ile Ala Arg Glu Ala Glu Ala Ala Val 
            420                 425                 430         


Tyr His Arg Gln Leu Phe Glu Glu Leu Arg Arg Ala Ala Pro Leu Ser 
        435                 440                 445             


Arg Asp Pro Thr Glu Val Thr Ala Ile Gly Ala Val Glu Ala Ser Phe 
    450                 455                 460                 


Lys Cys Cys Ala Ala Ala Ile Ile Val Leu Thr Lys Thr Gly Arg Ser 
465                 470                 475                 480 


Ala Gln Leu Leu Ser Gln Tyr Arg Pro Arg Ala Ala Val Ile Ala Val 
                485                 490                 495     


Thr Arg Ser Ala Gln Ala Ala Arg Gln Val His Leu Ser Arg Gly Val 
            500                 505                 510         


Phe Pro Leu Leu Tyr Arg Glu Pro Pro Glu Ala Ile Trp Ala Asp Asp 
        515                 520                 525             


Val Asp Arg Arg Val Gln Phe Gly Ile Glu Ser Gly Lys Leu Arg Gly 
    530                 535                 540                 


Phe Leu Arg Val Gly Asp Leu Val Ile Val Val Thr Gly Trp Arg Pro 
545                 550                 555                 560 


Gly Ser Gly Tyr Thr Asn Ile Met Arg Val Leu Ser Val Ser 
                565                 570                 


<210>  17
<211>  543
<212>  PRT
<213>  Rattus norvegicus

<400>  17

Met Glu Gly Pro Ala Gly Tyr Leu Arg Arg Ala Ser Val Ala Gln Leu 
1               5                   10                  15      


Thr Gln Glu Leu Gly Thr Ala Phe Phe Gln Gln Gln Gln Leu Pro Ala 
            20                  25                  30          


Ala Met Ala Asp Thr Phe Leu Glu His Leu Cys Leu Leu Asp Ile Asp 
        35                  40                  45              


Ser Gln Pro Val Ala Ala Arg Ser Thr Ser Ile Ile Ala Thr Ile Gly 
    50                  55                  60                  


Pro Ala Ser Arg Ser Val Asp Arg Leu Lys Glu Met Ile Lys Ala Gly 
65                  70                  75                  80  


Met Asn Ile Ala Arg Leu Asn Phe Ser His Gly Ser His Glu Tyr His 
                85                  90                  95      


Ala Glu Ser Ile Ala Asn Ile Arg Glu Ala Thr Glu Ser Phe Ala Thr 
            100                 105                 110         


Ser Pro Leu Ser Tyr Arg Pro Val Ala Ile Ala Leu Asp Thr Lys Gly 
        115                 120                 125             


Pro Glu Ile Arg Thr Gly Val Leu Gln Gly Gly Pro Glu Ser Glu Val 
    130                 135                 140                 


Glu Ile Val Lys Gly Ser Gln Val Leu Val Thr Val Asp Pro Lys Phe 
145                 150                 155                 160 


Gln Thr Arg Gly Asp Ala Lys Thr Val Trp Val Asp Tyr His Asn Ile 
                165                 170                 175     


Thr Arg Val Val Ala Val Gly Gly Arg Ile Tyr Ile Asp Asp Gly Leu 
            180                 185                 190         


Ile Ser Leu Val Val Gln Lys Ile Gly Pro Glu Gly Leu Val Thr Glu 
        195                 200                 205             


Val Glu His Gly Gly Ile Leu Gly Ser Arg Lys Gly Val Asn Leu Pro 
    210                 215                 220                 


Asn Thr Glu Val Asp Leu Pro Gly Leu Ser Glu Gln Asp Leu Leu Asp 
225                 230                 235                 240 


Leu Arg Phe Gly Val Gln His Asn Val Asp Ile Ile Phe Ala Ser Phe 
                245                 250                 255     


Val Arg Lys Ala Ser Asp Val Leu Ala Val Arg Asp Ala Leu Gly Pro 
            260                 265                 270         


Glu Gly Gln Asn Ile Lys Ile Ile Ser Lys Ile Glu Asn His Glu Gly 
        275                 280                 285             


Val Lys Lys Phe Asp Glu Ile Leu Glu Val Ser Asp Gly Ile Met Val 
    290                 295                 300                 


Ala Arg Gly Asp Leu Gly Ile Glu Ile Pro Ala Glu Lys Val Phe Leu 
305                 310                 315                 320 


Ala Gln Lys Met Met Ile Gly Arg Cys Asn Leu Ala Gly Lys Pro Val 
                325                 330                 335     


Val Cys Ala Thr Gln Met Leu Glu Ser Met Ile Thr Lys Ala Arg Pro 
            340                 345                 350         


Thr Arg Ala Glu Thr Ser Asp Val Ala Asn Ala Val Leu Asp Gly Ala 
        355                 360                 365             


Asp Cys Ile Met Leu Ser Gly Glu Thr Ala Lys Gly Ser Phe Pro Val 
    370                 375                 380                 


Glu Ala Val Met Met Gln His Ala Ile Ala Arg Glu Ala Glu Ala Ala 
385                 390                 395                 400 


Val Tyr His Arg Gln Leu Phe Glu Glu Leu Arg Arg Ala Ala Pro Leu 
                405                 410                 415     


Ser Arg Asp Pro Thr Glu Val Thr Ala Ile Gly Ala Val Glu Ala Ser 
            420                 425                 430         


Phe Lys Cys Cys Ala Ala Ala Ile Ile Val Leu Thr Lys Thr Gly Arg 
        435                 440                 445             


Ser Ala Gln Leu Leu Ser Gln Tyr Arg Pro Arg Ala Ala Val Ile Ala 
    450                 455                 460                 


Val Thr Arg Ser Ala Gln Ala Ala Arg Gln Val His Leu Ser Arg Gly 
465                 470                 475                 480 


Val Phe Pro Leu Leu Tyr Arg Glu Pro Pro Glu Ala Ile Trp Ala Asp 
                485                 490                 495     


Asp Val Asp Arg Arg Val Gln Phe Gly Ile Glu Ser Gly Lys Leu Arg 
            500                 505                 510         


Gly Phe Leu Arg Val Gly Asp Leu Val Ile Val Val Thr Gly Trp Arg 
        515                 520                 525             


Pro Gly Ser Gly Tyr Thr Asn Ile Met Arg Val Leu Ser Val Ser 
    530                 535                 540             


<210>  18
<211>  531
<212>  PRT
<213>  Rattus norvegicus

<400>  18

Met Ser Lys Ser His Ser Glu Ala Gly Ser Ala Phe Ile Gln Thr Gln 
1               5                   10                  15      


Gln Leu His Ala Ala Met Ala Asp Thr Phe Leu Glu His Met Cys Arg 
            20                  25                  30          


Leu Asp Ile Asp Ser Ala Pro Ile Thr Ala Arg Asn Thr Gly Ile Ile 
        35                  40                  45              


Cys Thr Ile Gly Pro Ala Ser Arg Ser Val Glu Thr Leu Lys Glu Met 
    50                  55                  60                  


Ile Lys Ser Gly Met Asn Val Ala Arg Met Asn Phe Ser His Gly Thr 
65                  70                  75                  80  


His Glu Tyr His Ala Glu Thr Ile Lys Asn Val Arg Thr Ala Thr Glu 
                85                  90                  95      


Ser Phe Ala Ser Asp Pro Ile Leu Tyr Arg Pro Val Ala Val Ala Leu 
            100                 105                 110         


Asp Thr Lys Gly Pro Glu Ile Arg Thr Gly Leu Ile Lys Gly Ser Gly 
        115                 120                 125             


Thr Ala Glu Val Glu Leu Lys Lys Gly Ala Thr Leu Lys Ile Thr Leu 
    130                 135                 140                 


Asp Asn Ala Tyr Met Glu Lys Cys Asp Glu Asn Ile Leu Trp Leu Asp 
145                 150                 155                 160 


Tyr Lys Asn Ile Cys Lys Val Val Asp Val Gly Ser Lys Val Tyr Val 
                165                 170                 175     


Asp Asp Gly Leu Ile Ser Leu Gln Val Lys Gln Lys Gly Pro Asp Phe 
            180                 185                 190         


Leu Val Thr Glu Val Glu Asn Gly Gly Phe Leu Gly Ser Lys Lys Gly 
        195                 200                 205             


Val Asn Leu Pro Gly Ala Ala Val Asp Leu Pro Ala Val Ser Glu Lys 
    210                 215                 220                 


Asp Ile Gln Asp Leu Lys Phe Gly Val Glu Gln Asp Val Asp Met Val 
225                 230                 235                 240 


Phe Ala Ser Phe Ile Arg Lys Ala Ala Asp Val His Glu Val Arg Lys 
                245                 250                 255     


Ile Leu Gly Glu Lys Gly Lys Asn Ile Lys Ile Ile Ser Lys Ile Glu 
            260                 265                 270         


Asn His Glu Gly Val Arg Arg Phe Asp Glu Ile Leu Glu Ala Ser Asp 
        275                 280                 285             


Gly Ile Met Val Ala Arg Gly Asp Leu Gly Ile Glu Ile Pro Ala Glu 
    290                 295                 300                 


Lys Val Phe Leu Ala Gln Lys Met Ile Ile Gly Arg Cys Asn Arg Ala 
305                 310                 315                 320 


Gly Lys Pro Val Ile Cys Ala Thr Gln Met Leu Glu Ser Met Ile Lys 
                325                 330                 335     


Lys Pro Arg Pro Thr Arg Ala Glu Gly Ser Asp Val Ala Asn Ala Val 
            340                 345                 350         


Leu Asp Gly Ala Asp Cys Ile Met Leu Ser Gly Glu Thr Ala Lys Gly 
        355                 360                 365             


Asp Tyr Pro Leu Glu Ala Val Arg Met Gln His Leu Ile Ala Arg Glu 
    370                 375                 380                 


Ala Glu Ala Ala Met Phe His Arg Lys Leu Phe Glu Glu Leu Ala Arg 
385                 390                 395                 400 


Ser Ser Ser His Ser Thr Asp Leu Met Glu Ala Met Ala Met Gly Ser 
                405                 410                 415     


Val Glu Ala Ser Tyr Lys Cys Leu Ala Ala Ala Leu Ile Val Leu Thr 
            420                 425                 430         


Glu Ser Gly Arg Ser Ala His Gln Val Ala Arg Tyr Arg Pro Arg Ala 
        435                 440                 445             


Pro Ile Ile Ala Val Thr Arg Asn His Gln Thr Ala Arg Gln Ala His 
    450                 455                 460                 


Leu Tyr Arg Gly Ile Phe Pro Val Val Cys Lys Asp Pro Val Gln Glu 
465                 470                 475                 480 


Ala Trp Ala Glu Asp Val Asp Leu Arg Val Asn Leu Ala Met Asn Val 
                485                 490                 495     


Gly Lys Ala Arg Gly Phe Phe Lys Lys Gly Asp Val Val Ile Val Leu 
            500                 505                 510         


Thr Gly Trp Arg Pro Gly Ser Gly Phe Thr Asn Thr Met Arg Val Val 
        515                 520                 525             


Pro Val Pro 
    530     


<210>  19
<211>  531
<212>  PRT
<213>  Rattus norvegicus

<400>  19

Met Pro Lys Pro Asp Ser Glu Ala Gly Thr Ala Phe Ile Gln Thr Gln 
1               5                   10                  15      


Gln Leu His Ala Ala Met Ala Asp Thr Phe Leu Glu His Met Cys Arg 
            20                  25                  30          


Leu Asp Ile Asp Ser Ala Pro Ile Thr Ala Arg Asn Thr Gly Ile Ile 
        35                  40                  45              


Cys Thr Ile Gly Pro Ala Ser Arg Ser Val Glu Met Leu Lys Glu Met 
    50                  55                  60                  


Ile Lys Ser Gly Met Asn Val Ala Arg Leu Asn Phe Ser His Gly Thr 
65                  70                  75                  80  


His Glu Tyr His Ala Glu Thr Ile Lys Asn Val Arg Ala Ala Thr Glu 
                85                  90                  95      


Ser Phe Ala Ser Asp Pro Ile Leu Tyr Arg Pro Val Ala Val Ala Leu 
            100                 105                 110         


Asp Thr Lys Gly Pro Glu Ile Arg Thr Gly Leu Ile Lys Gly Ser Gly 
        115                 120                 125             


Thr Ala Glu Val Glu Leu Lys Lys Gly Ala Thr Leu Lys Ile Thr Leu 
    130                 135                 140                 


Asp Asn Ala Tyr Met Glu Lys Cys Asp Glu Asn Ile Leu Trp Leu Asp 
145                 150                 155                 160 


Tyr Lys Asn Ile Cys Lys Val Val Glu Val Gly Ser Lys Ile Tyr Val 
                165                 170                 175     


Asp Asp Gly Leu Ile Ser Leu Gln Val Lys Glu Lys Gly Ala Asp Tyr 
            180                 185                 190         


Leu Val Thr Glu Val Glu Asn Gly Gly Ser Leu Gly Ser Lys Lys Gly 
        195                 200                 205             


Val Asn Leu Pro Gly Ala Ala Val Asp Leu Pro Ala Val Ser Glu Lys 
    210                 215                 220                 


Asp Ile Gln Asp Leu Lys Phe Gly Val Glu Gln Asp Val Asp Met Val 
225                 230                 235                 240 


Phe Ala Ser Phe Ile Arg Lys Ala Ala Asp Val His Glu Val Arg Lys 
                245                 250                 255     


Val Leu Gly Glu Lys Gly Lys Asn Ile Lys Ile Ile Ser Lys Ile Glu 
            260                 265                 270         


Asn His Glu Gly Val Arg Arg Phe Asp Glu Ile Leu Glu Ala Ser Asp 
        275                 280                 285             


Gly Ile Met Val Ala Arg Gly Asp Leu Gly Ile Glu Ile Pro Ala Glu 
    290                 295                 300                 


Lys Val Phe Leu Ala Gln Lys Met Met Ile Gly Arg Cys Asn Arg Ala 
305                 310                 315                 320 


Gly Lys Pro Val Ile Cys Ala Thr Gln Met Leu Glu Ser Met Ile Lys 
                325                 330                 335     


Lys Pro Arg Pro Thr Arg Ala Glu Gly Ser Asp Val Ala Asn Ala Val 
            340                 345                 350         


Leu Asp Gly Ala Asp Cys Ile Met Leu Ser Gly Glu Thr Ala Lys Gly 
        355                 360                 365             


Asp Tyr Pro Leu Glu Ala Val Arg Met Gln His Leu Ile Ala Arg Glu 
    370                 375                 380                 


Ala Glu Ala Ala Val Phe His Arg Leu Leu Phe Glu Glu Leu Ala Arg 
385                 390                 395                 400 


Ala Ser Ser Gln Ser Thr Asp Pro Leu Glu Ala Met Ala Met Gly Ser 
                405                 410                 415     


Val Glu Ala Ser Tyr Lys Cys Leu Ala Ala Ala Leu Ile Val Leu Thr 
            420                 425                 430         


Glu Ser Gly Arg Ser Ala His Gln Val Ala Arg Tyr Arg Pro Arg Ala 
        435                 440                 445             


Pro Ile Ile Ala Val Thr Arg Asn Pro Gln Thr Ala Arg Gln Ala His 
    450                 455                 460                 


Leu Tyr Arg Gly Ile Phe Pro Val Leu Cys Lys Asp Ala Val Leu Asp 
465                 470                 475                 480 


Ala Trp Ala Glu Asp Val Asp Leu Arg Val Asn Leu Ala Met Asn Val 
                485                 490                 495     


Gly Lys Ala Arg Gly Phe Phe Lys Lys Gly Asp Val Val Ile Val Leu 
            500                 505                 510         


Thr Gly Trp Arg Pro Gly Ser Gly Phe Thr Asn Thr Met Arg Val Val 
        515                 520                 525             


Pro Val Pro 
    530     


<210>  20
<211>  381
<212>  PRT
<213>  Homo sapiens

<400>  20

Met Pro Phe Ser Asn Ser His Asn Ala Leu Lys Leu Arg Phe Pro Ala 
1               5                   10                  15      


Glu Asp Glu Phe Pro Asp Leu Ser Ala His Asn Asn His Met Ala Lys 
            20                  25                  30          


Val Leu Thr Pro Glu Leu Tyr Ala Glu Leu Arg Ala Lys Ser Thr Pro 
        35                  40                  45              


Ser Gly Phe Thr Leu Asp Asp Val Ile Gln Thr Gly Val Asp Asn Pro 
    50                  55                  60                  


Gly His Pro Tyr Ile Met Thr Val Gly Cys Val Ala Gly Asp Glu Glu 
65                  70                  75                  80  


Ser Tyr Glu Val Phe Lys Asp Leu Phe Asp Pro Ile Ile Glu Asp Arg 
                85                  90                  95      


His Gly Gly Tyr Lys Pro Ser Asp Glu His Lys Thr Asp Leu Asn Pro 
            100                 105                 110         


Asp Asn Leu Gln Gly Gly Asp Asp Leu Asp Pro Asn Tyr Val Leu Ser 
        115                 120                 125             


Ser Arg Val Arg Thr Gly Arg Ser Ile Arg Gly Phe Cys Leu Pro Pro 
    130                 135                 140                 


His Cys Ser Arg Gly Glu Arg Arg Ala Ile Glu Lys Leu Ala Val Glu 
145                 150                 155                 160 


Ala Leu Ser Ser Leu Asp Gly Asp Leu Ala Gly Arg Tyr Tyr Ala Leu 
                165                 170                 175     


Lys Ser Met Thr Glu Ala Glu Gln Gln Gln Leu Ile Asp Asp His Phe 
            180                 185                 190         


Leu Phe Asp Lys Pro Val Ser Pro Leu Leu Leu Ala Ser Gly Met Ala 
        195                 200                 205             


Arg Asp Trp Pro Asp Ala Arg Gly Ile Trp His Asn Asp Asn Lys Thr 
    210                 215                 220                 


Phe Leu Val Trp Val Asn Glu Glu Asp His Leu Arg Val Ile Ser Met 
225                 230                 235                 240 


Gln Lys Gly Gly Asn Met Lys Glu Val Phe Thr Arg Phe Cys Thr Gly 
                245                 250                 255     


Leu Thr Gln Ile Glu Thr Leu Phe Lys Ser Lys Asp Tyr Glu Phe Met 
            260                 265                 270         


Trp Asn Pro His Leu Gly Tyr Ile Leu Thr Cys Pro Ser Asn Leu Gly 
        275                 280                 285             


Thr Gly Leu Arg Ala Gly Val His Ile Lys Leu Pro Asn Leu Gly Lys 
    290                 295                 300                 


His Glu Lys Phe Ser Glu Val Leu Lys Arg Leu Arg Leu Gln Lys Arg 
305                 310                 315                 320 


Gly Thr Gly Gly Val Asp Thr Ala Ala Val Gly Gly Val Phe Asp Val 
                325                 330                 335     


Ser Asn Ala Asp Arg Leu Gly Phe Ser Glu Val Glu Leu Val Gln Met 
            340                 345                 350         


Val Val Asp Gly Val Lys Leu Leu Ile Glu Met Glu Gln Arg Leu Glu 
        355                 360                 365             


Gln Gly Gln Ala Ile Asp Asp Leu Met Pro Ala Gln Lys 
    370                 375                 380     


<210>  21
<211>  381
<212>  PRT
<213>  Homo sapiens

<400>  21

Met Pro Phe Gly Asn Thr His Asn Lys Phe Lys Leu Asn Tyr Lys Pro 
1               5                   10                  15      


Glu Glu Glu Tyr Pro Asp Leu Ser Lys His Asn Asn His Met Ala Lys 
            20                  25                  30          


Val Leu Thr Leu Glu Leu Tyr Lys Lys Leu Arg Asp Lys Glu Thr Pro 
        35                  40                  45              


Ser Gly Phe Thr Val Asp Asp Val Ile Gln Thr Gly Val Asp Asn Pro 
    50                  55                  60                  


Gly His Pro Phe Ile Met Thr Val Gly Cys Val Ala Gly Asp Glu Glu 
65                  70                  75                  80  


Ser Tyr Glu Val Phe Lys Glu Leu Phe Asp Pro Ile Ile Ser Asp Arg 
                85                  90                  95      


His Gly Gly Tyr Lys Pro Thr Asp Lys His Lys Thr Asp Leu Asn His 
            100                 105                 110         


Glu Asn Leu Lys Gly Gly Asp Asp Leu Asp Pro Asn Tyr Val Leu Ser 
        115                 120                 125             


Ser Arg Val Arg Thr Gly Arg Ser Ile Lys Gly Tyr Thr Leu Pro Pro 
    130                 135                 140                 


His Cys Ser Arg Gly Glu Arg Arg Ala Val Glu Lys Leu Ser Val Glu 
145                 150                 155                 160 


Ala Leu Asn Ser Leu Thr Gly Glu Phe Lys Gly Lys Tyr Tyr Pro Leu 
                165                 170                 175     


Lys Ser Met Thr Glu Lys Glu Gln Gln Gln Leu Ile Asp Asp His Phe 
            180                 185                 190         


Leu Phe Asp Lys Pro Val Ser Pro Leu Leu Leu Ala Ser Gly Met Ala 
        195                 200                 205             


Arg Asp Trp Pro Asp Ala Arg Gly Ile Trp His Asn Asp Asn Lys Ser 
    210                 215                 220                 


Phe Leu Val Trp Val Asn Glu Glu Asp His Leu Arg Val Ile Ser Met 
225                 230                 235                 240 


Glu Lys Gly Gly Asn Met Lys Glu Val Phe Arg Arg Phe Cys Val Gly 
                245                 250                 255     


Leu Gln Lys Ile Glu Glu Ile Phe Lys Lys Ala Gly His Pro Phe Met 
            260                 265                 270         


Trp Asn Gln His Leu Gly Tyr Val Leu Thr Cys Pro Ser Asn Leu Gly 
        275                 280                 285             


Thr Gly Leu Arg Gly Gly Val His Val Lys Leu Ala His Leu Ser Lys 
    290                 295                 300                 


His Pro Lys Phe Glu Glu Ile Leu Thr Arg Leu Arg Leu Gln Lys Arg 
305                 310                 315                 320 


Gly Thr Gly Gly Val Asp Thr Ala Ala Val Gly Ser Val Phe Asp Val 
                325                 330                 335     


Ser Asn Ala Asp Arg Leu Gly Ser Ser Glu Val Glu Gln Val Gln Leu 
            340                 345                 350         


Val Val Asp Gly Val Lys Leu Met Val Glu Met Glu Lys Lys Leu Glu 
        355                 360                 365             


Lys Gly Gln Ser Ile Asp Asp Met Ile Pro Ala Gln Lys 
    370                 375                 380     


<210>  22
<211>  417
<212>  PRT
<213>  Homo sapiens

<400>  22

Met Ala Gly Pro Phe Ser Arg Leu Leu Ser Ala Arg Pro Gly Leu Arg 
1               5                   10                  15      


Leu Leu Ala Leu Ala Gly Ala Gly Ser Leu Ala Ala Gly Phe Leu Leu 
            20                  25                  30          


Arg Pro Glu Pro Val Arg Ala Ala Ser Glu Arg Arg Arg Leu Tyr Pro 
        35                  40                  45              


Pro Ser Ala Glu Tyr Pro Asp Leu Arg Lys His Asn Asn Cys Met Ala 
    50                  55                  60                  


Ser His Leu Thr Pro Ala Val Tyr Ala Arg Leu Cys Asp Lys Thr Thr 
65                  70                  75                  80  


Pro Thr Gly Trp Thr Leu Asp Gln Cys Ile Gln Thr Gly Val Asp Asn 
                85                  90                  95      


Pro Gly His Pro Phe Ile Lys Thr Val Gly Met Val Ala Gly Asp Glu 
            100                 105                 110         


Glu Thr Tyr Glu Val Phe Ala Asp Leu Phe Asp Pro Val Ile Gln Glu 
        115                 120                 125             


Arg His Asn Gly Tyr Asp Pro Arg Thr Met Lys His Thr Thr Asp Leu 
    130                 135                 140                 


Asp Ala Ser Lys Ile Arg Ser Gly Tyr Phe Asp Glu Arg Tyr Val Leu 
145                 150                 155                 160 


Ser Ser Arg Val Arg Thr Gly Arg Ser Ile Arg Gly Leu Ser Leu Pro 
                165                 170                 175     


Pro Ala Cys Thr Arg Ala Glu Arg Arg Glu Val Glu Arg Val Val Val 
            180                 185                 190         


Asp Ala Leu Ser Gly Leu Lys Gly Asp Leu Ala Gly Arg Tyr Tyr Arg 
        195                 200                 205             


Leu Ser Glu Met Thr Glu Ala Glu Gln Gln Gln Leu Ile Asp Asp His 
    210                 215                 220                 


Phe Leu Phe Asp Lys Pro Val Ser Pro Leu Leu Thr Ala Ala Gly Met 
225                 230                 235                 240 


Ala Arg Asp Trp Pro Asp Ala Arg Gly Ile Trp His Asn Asn Glu Lys 
                245                 250                 255     


Ser Phe Leu Ile Trp Val Asn Glu Glu Asp His Thr Arg Val Ile Ser 
            260                 265                 270         


Met Glu Lys Gly Gly Asn Met Lys Arg Val Phe Glu Arg Phe Cys Arg 
        275                 280                 285             


Gly Leu Lys Glu Val Glu Arg Leu Ile Gln Glu Arg Gly Trp Glu Phe 
    290                 295                 300                 


Met Trp Asn Glu Arg Leu Gly Tyr Ile Leu Thr Cys Pro Ser Asn Leu 
305                 310                 315                 320 


Gly Thr Gly Leu Arg Ala Gly Val His Ile Lys Leu Pro Leu Leu Ser 
                325                 330                 335     


Lys Asp Ser Arg Phe Pro Lys Ile Leu Glu Asn Leu Arg Leu Gln Lys 
            340                 345                 350         


Arg Gly Thr Gly Gly Val Asp Thr Ala Ala Thr Gly Gly Val Phe Asp 
        355                 360                 365             


Ile Ser Asn Leu Asp Arg Leu Gly Lys Ser Glu Val Glu Leu Val Gln 
    370                 375                 380                 


Leu Val Ile Asp Gly Val Asn Tyr Leu Ile Asp Cys Glu Arg Arg Leu 
385                 390                 395                 400 


Glu Arg Gly Gln Asp Ile Arg Ile Pro Thr Pro Val Ile His Thr Lys 
                405                 410                 415     


His 
    


<210>  23
<211>  419
<212>  PRT
<213>  Homo sapiens

<400>  23

Met Ala Ser Ile Phe Ser Lys Leu Leu Thr Gly Arg Asn Ala Ser Leu 
1               5                   10                  15      


Leu Phe Ala Thr Met Gly Thr Ser Val Leu Thr Thr Gly Tyr Leu Leu 
            20                  25                  30          


Asn Arg Gln Lys Val Cys Ala Glu Val Arg Glu Gln Pro Arg Leu Phe 
        35                  40                  45              


Pro Pro Ser Ala Asp Tyr Pro Asp Leu Arg Lys His Asn Asn Cys Met 
    50                  55                  60                  


Ala Glu Cys Leu Thr Pro Ala Ile Tyr Ala Lys Leu Arg Asn Lys Val 
65                  70                  75                  80  


Thr Pro Asn Gly Tyr Thr Leu Asp Gln Cys Ile Gln Thr Gly Val Asp 
                85                  90                  95      


Asn Pro Gly His Pro Phe Ile Lys Thr Val Gly Met Val Ala Gly Asp 
            100                 105                 110         


Glu Glu Ser Tyr Glu Val Phe Ala Asp Leu Phe Asp Pro Val Ile Lys 
        115                 120                 125             


Leu Arg His Asn Gly Tyr Asp Pro Arg Val Met Lys His Thr Thr Asp 
    130                 135                 140                 


Leu Asp Ala Ser Lys Ile Thr Gln Gly Gln Phe Asp Glu His Tyr Val 
145                 150                 155                 160 


Leu Ser Ser Arg Val Arg Thr Gly Arg Ser Ile Arg Gly Leu Ser Leu 
                165                 170                 175     


Pro Pro Ala Cys Thr Arg Ala Glu Arg Arg Glu Val Glu Asn Val Ala 
            180                 185                 190         


Ile Thr Ala Leu Glu Gly Leu Lys Gly Asp Leu Ala Gly Arg Tyr Tyr 
        195                 200                 205             


Lys Leu Ser Glu Met Thr Glu Gln Asp Gln Gln Arg Leu Ile Asp Asp 
    210                 215                 220                 


His Phe Leu Phe Asp Lys Pro Val Ser Pro Leu Leu Thr Cys Ala Gly 
225                 230                 235                 240 


Met Ala Arg Asp Trp Pro Asp Ala Arg Gly Ile Trp His Asn Tyr Asp 
                245                 250                 255     


Lys Thr Phe Leu Ile Trp Ile Asn Glu Glu Asp His Thr Arg Val Ile 
            260                 265                 270         


Ser Met Glu Lys Gly Gly Asn Met Lys Arg Val Phe Glu Arg Phe Cys 
        275                 280                 285             


Arg Gly Leu Lys Glu Val Glu Arg Leu Ile Gln Glu Arg Gly Trp Glu 
    290                 295                 300                 


Phe Met Trp Asn Glu Arg Leu Gly Tyr Ile Leu Thr Cys Pro Ser Asn 
305                 310                 315                 320 


Leu Gly Thr Gly Leu Arg Ala Gly Val His Val Arg Ile Pro Lys Leu 
                325                 330                 335     


Ser Lys Asp Pro Arg Phe Ser Lys Ile Leu Glu Asn Leu Arg Leu Gln 
            340                 345                 350         


Lys Arg Gly Thr Gly Gly Val Asp Thr Ala Ala Val Ala Asp Val Tyr 
        355                 360                 365             


Asp Ile Ser Asn Ile Asp Arg Ile Gly Arg Ser Glu Val Glu Leu Val 
    370                 375                 380                 


Gln Ile Val Ile Asp Gly Val Asn Tyr Leu Val Asp Cys Glu Lys Lys 
385                 390                 395                 400 


Leu Glu Arg Gly Gln Asp Ile Lys Val Pro Pro Pro Leu Pro Gln Phe 
                405                 410                 415     


Gly Lys Lys 
            


<210>  24
<211>  523
<212>  PRT
<213>  Mus musculus

<400>  24

Met Ala Ala Ala Leu Gln Val Leu Pro Cys Leu Leu Arg Ala Pro Ser 
1               5                   10                  15      


Arg Pro Leu Leu Trp Gly Pro Pro Val Ala Arg Met Thr Ser Gly Met 
            20                  25                  30          


Ala Leu Ala Glu Gln Ala Arg Gln Leu Phe Asp Ser Ala Val Gly Ala 
        35                  40                  45              


Val Gln Pro Gly Pro Met Leu Gln Arg Thr Leu Ser Leu Asp Pro Ser 
    50                  55                  60                  


Gly Arg Gln Leu Lys Val Arg Asp Arg Thr Phe Gln Leu Arg Glu Asn 
65                  70                  75                  80  


Leu Tyr Leu Val Gly Phe Gly Lys Ala Val Leu Gly Met Ala Ala Ala 
                85                  90                  95      


Ala Glu Glu Leu Leu Ala Gln His Leu Val Gln Gly Val Ile Ser Val 
            100                 105                 110         


Pro Lys Gly Ile Arg Ala Ala Met Glu His Ala Gly Lys Lys Glu Met 
        115                 120                 125             


Leu Leu Lys Pro His Ser Arg Val Gln Val Phe Glu Gly Ala Glu Asp 
    130                 135                 140                 


Asn Leu Pro Asp Arg Asp Ala Leu Arg Ala Ala Leu Thr Ile Gln Gln 
145                 150                 155                 160 


Leu Ala Glu Gly Leu Thr Ala Asp Asp Leu Leu Leu Val Leu Ile Ser 
                165                 170                 175     


Gly Gly Gly Ser Ala Leu Leu Pro Ala Pro Ile Pro Pro Val Thr Leu 
            180                 185                 190         


Glu Glu Lys Gln Met Leu Thr Lys Leu Leu Ala Ala Arg Gly Ala Thr 
        195                 200                 205             


Ile Gln Glu Leu Asn Thr Ile Arg Lys Ala Leu Ser Gln Leu Lys Gly 
    210                 215                 220                 


Gly Gly Leu Ala Gln Ala Ala Tyr Pro Ala Gln Val Ile Ser Leu Ile 
225                 230                 235                 240 


Leu Ser Asp Val Ile Gly Asp Pro Leu Glu Val Ile Ala Ser Gly Pro 
                245                 250                 255     


Thr Val Ala Ser Ala His Ser Val Gln Asp Cys Leu His Ile Leu Asn 
            260                 265                 270         


His Tyr Gly Leu Arg Ala Ala Leu Pro Arg Ser Val Lys Thr Val Leu 
        275                 280                 285             


Ser Arg Ala Asp Ser Asp Pro His Gly Pro His Thr Cys Gly His Val 
    290                 295                 300                 


Leu Asn Val Ile Ile Gly Ser Asn Ser Leu Ala Leu Ala Glu Ala Gln 
305                 310                 315                 320 


Arg Gln Ala Glu Val Leu Gly Tyr His Ala Met Val Leu Ser Thr Ala 
                325                 330                 335     


Met Gln Gly Asp Val Lys Arg Val Ala Arg Phe Tyr Gly Leu Leu Ala 
            340                 345                 350         


Arg Val Ala Ala Ala His Leu Thr Pro Ser Leu Ala Glu Arg Pro Leu 
        355                 360                 365             


Glu Glu Glu Ala Glu Leu His Gln Leu Ala Ala Glu Leu Gln Leu Pro 
    370                 375                 380                 


Asp Leu Gln Leu Glu Glu Ala Leu Glu Ala Val Ala Lys Ala Lys Gly 
385                 390                 395                 400 


Pro Val Cys Leu Leu Ala Gly Gly Glu Pro Thr Val Gln Leu Gln Gly 
                405                 410                 415     


Ser Gly Lys Gly Gly Arg Asn Gln Glu Leu Ala Leu His Val Gly Val 
            420                 425                 430         


Glu Leu Gly Arg Gln Pro Leu Gly Pro Ile Asp Val Leu Phe Leu Ser 
        435                 440                 445             


Gly Gly Thr Asp Gly Gln Asp Gly Pro Thr Lys Val Ala Gly Ala Trp 
    450                 455                 460                 


Val Met Ser Asp Leu Ile Ser Gln Ala Ser Ala Glu Ser Leu Asp Ile 
465                 470                 475                 480 


Ala Thr Ser Leu Thr Asn Asn Asp Ser Tyr Thr Phe Phe Cys Arg Phe 
                485                 490                 495     


Arg Gly Gly Thr His Leu Leu His Thr Gly Leu Thr Gly Thr Asn Val 
            500                 505                 510         


Met Asp Val His Leu Leu Ile Leu His Pro Gln 
        515                 520             


<210>  25
<211>  396
<212>  PRT
<213>  Mus musculus

<400>  25

Met Leu Leu Lys Pro His Ser Arg Val Gln Val Phe Glu Gly Ala Glu 
1               5                   10                  15      


Asp Asn Leu Pro Asp Arg Asp Ala Leu Arg Ala Ala Leu Thr Ile Gln 
            20                  25                  30          


Gln Leu Ala Glu Gly Leu Thr Ala Asp Asp Leu Leu Leu Val Leu Ile 
        35                  40                  45              


Ser Gly Gly Gly Ser Ala Leu Leu Pro Ala Pro Ile Pro Pro Val Thr 
    50                  55                  60                  


Leu Glu Glu Lys Gln Met Leu Thr Lys Leu Leu Ala Ala Arg Gly Ala 
65                  70                  75                  80  


Thr Ile Gln Glu Leu Asn Thr Ile Arg Lys Ala Leu Ser Gln Leu Lys 
                85                  90                  95      


Gly Gly Gly Leu Ala Gln Ala Ala Tyr Pro Ala Gln Val Ile Ser Leu 
            100                 105                 110         


Ile Leu Ser Asp Val Ile Gly Asp Pro Leu Glu Val Ile Ala Ser Gly 
        115                 120                 125             


Pro Thr Val Ala Ser Ala His Ser Val Gln Asp Cys Leu His Ile Leu 
    130                 135                 140                 


Asn His Tyr Gly Leu Arg Ala Ala Leu Pro Arg Ser Val Lys Thr Val 
145                 150                 155                 160 


Leu Ser Arg Ala Asp Ser Asp Pro His Gly Pro His Thr Cys Gly His 
                165                 170                 175     


Val Leu Asn Val Ile Ile Gly Ser Asn Ser Leu Ala Leu Ala Glu Ala 
            180                 185                 190         


Gln Arg Gln Ala Glu Val Leu Gly Tyr His Ala Met Val Leu Ser Thr 
        195                 200                 205             


Ala Met Gln Gly Asp Val Lys Arg Val Ala Arg Phe Tyr Gly Leu Leu 
    210                 215                 220                 


Ala Arg Val Ala Ala Ala His Leu Thr Pro Ser Leu Ala Glu Arg Pro 
225                 230                 235                 240 


Leu Glu Glu Glu Ala Glu Leu His Gln Leu Ala Ala Glu Leu Gln Leu 
                245                 250                 255     


Pro Asp Leu Gln Leu Glu Glu Ala Leu Glu Ala Val Ala Lys Ala Lys 
            260                 265                 270         


Gly Pro Val Cys Leu Leu Ala Gly Gly Glu Pro Thr Val Gln Leu Gln 
        275                 280                 285             


Gly Ser Gly Lys Gly Gly Arg Asn Gln Glu Leu Ala Leu His Val Gly 
    290                 295                 300                 


Val Glu Leu Gly Arg Gln Pro Leu Gly Pro Ile Asp Val Leu Phe Leu 
305                 310                 315                 320 


Ser Gly Gly Thr Asp Gly Gln Asp Gly Pro Thr Lys Val Ala Gly Ala 
                325                 330                 335     


Trp Val Met Ser Asp Leu Ile Ser Gln Ala Ser Ala Glu Ser Leu Asp 
            340                 345                 350         


Ile Ala Thr Ser Leu Thr Asn Asn Asp Ser Tyr Thr Phe Phe Cys Arg 
        355                 360                 365             


Phe Arg Gly Gly Thr His Leu Leu His Thr Gly Leu Thr Gly Thr Asn 
    370                 375                 380                 


Val Met Asp Val His Leu Leu Ile Leu His Pro Gln 
385                 390                 395     


<210>  26
<211>  917
<212>  PRT
<213>  Homo sapiens

<400>  26

Met Ile Ala Ala Gln Leu Leu Ala Tyr Tyr Phe Thr Glu Leu Lys Asp 
1               5                   10                  15      


Asp Gln Val Lys Lys Ile Asp Lys Tyr Leu Tyr Ala Met Arg Leu Ser 
            20                  25                  30          


Asp Glu Thr Leu Ile Asp Ile Met Thr Arg Phe Arg Lys Glu Met Lys 
        35                  40                  45              


Asn Gly Leu Ser Arg Asp Phe Asn Pro Thr Ala Thr Val Lys Met Leu 
    50                  55                  60                  


Pro Thr Phe Val Arg Ser Ile Pro Asp Gly Ser Glu Lys Gly Asp Phe 
65                  70                  75                  80  


Ile Ala Leu Asp Leu Gly Gly Ser Ser Phe Arg Ile Leu Arg Val Gln 
                85                  90                  95      


Val Asn His Glu Lys Asn Gln Asn Val His Met Glu Ser Glu Val Tyr 
            100                 105                 110         


Asp Thr Pro Glu Asn Ile Val His Gly Ser Gly Ser Gln Leu Phe Asp 
        115                 120                 125             


His Val Ala Glu Cys Leu Gly Asp Phe Met Glu Lys Arg Lys Ile Lys 
    130                 135                 140                 


Asp Lys Lys Leu Pro Val Gly Phe Thr Phe Ser Phe Pro Cys Gln Gln 
145                 150                 155                 160 


Ser Lys Ile Asp Glu Ala Ile Leu Ile Thr Trp Thr Lys Arg Phe Lys 
                165                 170                 175     


Ala Ser Gly Val Glu Gly Ala Asp Val Val Lys Leu Leu Asn Lys Ala 
            180                 185                 190         


Ile Lys Lys Arg Gly Asp Tyr Asp Ala Asn Ile Val Ala Val Val Asn 
        195                 200                 205             


Asp Thr Val Gly Thr Met Met Thr Cys Gly Tyr Asp Asp Gln His Cys 
    210                 215                 220                 


Glu Val Gly Leu Ile Ile Gly Thr Gly Thr Asn Ala Cys Tyr Met Glu 
225                 230                 235                 240 


Glu Leu Arg His Ile Asp Leu Val Glu Gly Asp Glu Gly Arg Met Cys 
                245                 250                 255     


Ile Asn Thr Glu Trp Gly Ala Phe Gly Asp Asp Gly Ser Leu Glu Asp 
            260                 265                 270         


Ile Arg Thr Glu Phe Asp Arg Glu Ile Asp Arg Gly Ser Leu Asn Pro 
        275                 280                 285             


Gly Lys Gln Leu Phe Glu Lys Met Val Ser Gly Met Tyr Leu Gly Glu 
    290                 295                 300                 


Leu Val Arg Leu Ile Leu Val Lys Met Ala Lys Glu Gly Leu Leu Phe 
305                 310                 315                 320 


Glu Gly Arg Ile Thr Pro Glu Leu Leu Thr Arg Gly Lys Phe Asn Thr 
                325                 330                 335     


Ser Asp Val Ser Ala Ile Glu Lys Asn Lys Glu Gly Leu His Asn Ala 
            340                 345                 350         


Lys Glu Ile Leu Thr Arg Leu Gly Val Glu Pro Ser Asp Asp Asp Cys 
        355                 360                 365             


Val Ser Val Gln His Val Cys Thr Ile Val Ser Phe Arg Ser Ala Asn 
    370                 375                 380                 


Leu Val Ala Ala Thr Leu Gly Ala Ile Leu Asn Arg Leu Arg Asp Asn 
385                 390                 395                 400 


Lys Gly Thr Pro Arg Leu Arg Thr Thr Val Gly Val Asp Gly Ser Leu 
                405                 410                 415     


Tyr Lys Thr His Pro Gln Tyr Ser Arg Arg Phe His Lys Thr Leu Arg 
            420                 425                 430         


Arg Leu Val Pro Asp Ser Asp Val Arg Phe Leu Leu Ser Glu Ser Gly 
        435                 440                 445             


Ser Gly Lys Gly Ala Ala Met Val Thr Ala Val Ala Tyr Arg Leu Ala 
    450                 455                 460                 


Glu Gln His Arg Gln Ile Glu Glu Thr Leu Ala His Phe His Leu Thr 
465                 470                 475                 480 


Lys Asp Met Leu Leu Glu Val Lys Lys Arg Met Arg Ala Glu Met Glu 
                485                 490                 495     


Leu Gly Leu Arg Lys Gln Thr His Asn Asn Ala Val Val Lys Met Leu 
            500                 505                 510         


Pro Ser Phe Val Arg Arg Thr Pro Asp Gly Thr Glu Asn Gly Asp Phe 
        515                 520                 525             


Leu Ala Leu Asp Leu Gly Gly Thr Asn Phe Arg Val Leu Leu Val Lys 
    530                 535                 540                 


Ile Arg Ser Gly Lys Lys Arg Thr Val Glu Met His Asn Lys Ile Tyr 
545                 550                 555                 560 


Ala Ile Pro Ile Glu Ile Met Gln Gly Thr Gly Glu Glu Leu Phe Asp 
                565                 570                 575     


His Ile Val Ser Cys Ile Ser Asp Phe Leu Asp Tyr Met Gly Ile Lys 
            580                 585                 590         


Gly Pro Arg Met Pro Leu Gly Phe Thr Phe Ser Phe Pro Cys Gln Gln 
        595                 600                 605             


Thr Ser Leu Asp Ala Gly Ile Leu Ile Thr Trp Thr Lys Gly Phe Lys 
    610                 615                 620                 


Ala Thr Asp Cys Val Gly His Asp Val Val Thr Leu Leu Arg Asp Ala 
625                 630                 635                 640 


Ile Lys Arg Arg Glu Glu Phe Asp Leu Asp Val Val Ala Val Val Asn 
                645                 650                 655     


Asp Thr Val Gly Thr Met Met Thr Cys Ala Tyr Glu Glu Pro Thr Cys 
            660                 665                 670         


Glu Val Gly Leu Ile Val Gly Thr Gly Ser Asn Ala Cys Tyr Met Glu 
        675                 680                 685             


Glu Met Lys Asn Val Glu Met Val Glu Gly Asp Gln Gly Gln Met Cys 
    690                 695                 700                 


Ile Asn Met Glu Trp Gly Ala Phe Gly Asp Asn Gly Cys Leu Asp Asp 
705                 710                 715                 720 


Ile Arg Thr His Tyr Asp Arg Leu Val Asp Glu Tyr Ser Leu Asn Ala 
                725                 730                 735     


Gly Lys Gln Arg Tyr Glu Lys Met Ile Ser Gly Met Tyr Leu Gly Glu 
            740                 745                 750         


Ile Val Arg Asn Ile Leu Ile Asp Phe Thr Lys Lys Gly Phe Leu Phe 
        755                 760                 765             


Arg Gly Gln Ile Ser Glu Thr Leu Lys Thr Arg Gly Ile Phe Glu Thr 
    770                 775                 780                 


Lys Phe Leu Ser Gln Ile Glu Ser Asp Arg Leu Ala Leu Leu Gln Val 
785                 790                 795                 800 


Arg Ala Ile Leu Gln Gln Leu Gly Leu Asn Ser Thr Cys Asp Asp Ser 
                805                 810                 815     


Ile Leu Val Lys Thr Val Cys Gly Val Val Ser Arg Arg Ala Ala Gln 
            820                 825                 830         


Leu Cys Gly Ala Gly Met Ala Ala Val Val Asp Lys Ile Arg Glu Asn 
        835                 840                 845             


Arg Gly Leu Asp Arg Leu Asn Val Thr Val Gly Val Asp Gly Thr Leu 
    850                 855                 860                 


Tyr Lys Leu His Pro His Phe Ser Arg Ile Met His Gln Thr Val Lys 
865                 870                 875                 880 


Glu Leu Ser Pro Lys Cys Asn Val Ser Phe Leu Leu Ser Glu Asp Gly 
                885                 890                 895     


Ser Gly Lys Gly Ala Ala Leu Ile Thr Ala Val Gly Val Arg Leu Arg 
            900                 905                 910         


Thr Glu Ala Ser Ser 
        915         


<210>  27
<211>  917
<212>  PRT
<213>  Homo sapiens

<400>  27

Met Ile Ala Ser His Leu Leu Ala Tyr Phe Phe Thr Glu Leu Asn His 
1               5                   10                  15      


Asp Gln Val Gln Lys Val Asp Gln Tyr Leu Tyr His Met Arg Leu Ser 
            20                  25                  30          


Asp Glu Thr Leu Leu Glu Ile Ser Lys Arg Phe Arg Lys Glu Met Glu 
        35                  40                  45              


Lys Gly Leu Gly Ala Thr Thr His Pro Thr Ala Ala Val Lys Met Leu 
    50                  55                  60                  


Pro Thr Phe Val Arg Ser Thr Pro Asp Gly Thr Glu His Gly Glu Phe 
65                  70                  75                  80  


Leu Ala Leu Asp Leu Gly Gly Thr Asn Phe Arg Val Leu Trp Val Lys 
                85                  90                  95      


Val Thr Asp Asn Gly Leu Gln Lys Val Glu Met Glu Asn Gln Ile Tyr 
            100                 105                 110         


Ala Ile Pro Glu Asp Ile Met Arg Gly Ser Gly Thr Gln Leu Phe Asp 
        115                 120                 125             


His Ile Ala Glu Cys Leu Ala Asn Phe Met Asp Lys Leu Gln Ile Lys 
    130                 135                 140                 


Asp Lys Lys Leu Pro Leu Gly Phe Thr Phe Ser Phe Pro Cys His Gln 
145                 150                 155                 160 


Thr Lys Leu Asp Glu Ser Phe Leu Val Ser Trp Thr Lys Gly Phe Lys 
                165                 170                 175     


Ser Ser Gly Val Glu Gly Arg Asp Val Val Ala Leu Ile Arg Lys Ala 
            180                 185                 190         


Ile Gln Arg Arg Gly Asp Phe Asp Ile Asp Ile Val Ala Val Val Asn 
        195                 200                 205             


Asp Thr Val Gly Thr Met Met Thr Cys Gly Tyr Asp Asp His Asn Cys 
    210                 215                 220                 


Glu Ile Gly Leu Ile Val Gly Thr Gly Ser Asn Ala Cys Tyr Met Glu 
225                 230                 235                 240 


Glu Met Arg His Ile Asp Met Val Glu Gly Asp Glu Gly Arg Met Cys 
                245                 250                 255     


Ile Asn Met Glu Trp Gly Ala Phe Gly Asp Asp Gly Ser Leu Asn Asp 
            260                 265                 270         


Ile Arg Thr Glu Phe Asp Gln Glu Ile Asp Met Gly Ser Leu Asn Pro 
        275                 280                 285             


Gly Lys Gln Leu Phe Glu Lys Met Ile Ser Gly Met Tyr Met Gly Glu 
    290                 295                 300                 


Leu Val Arg Leu Ile Leu Val Lys Met Ala Lys Glu Glu Leu Leu Phe 
305                 310                 315                 320 


Gly Gly Lys Leu Ser Pro Glu Leu Leu Asn Thr Gly Arg Phe Glu Thr 
                325                 330                 335     


Lys Asp Ile Ser Asp Ile Glu Gly Glu Lys Asp Gly Ile Arg Lys Ala 
            340                 345                 350         


Arg Glu Val Leu Met Arg Leu Gly Leu Asp Pro Thr Gln Glu Asp Cys 
        355                 360                 365             


Val Ala Thr His Arg Ile Cys Gln Ile Val Ser Thr Arg Ser Ala Ser 
    370                 375                 380                 


Leu Cys Ala Ala Thr Leu Ala Ala Val Leu Gln Arg Ile Lys Glu Asn 
385                 390                 395                 400 


Lys Gly Glu Glu Arg Leu Arg Ser Thr Ile Gly Val Asp Gly Ser Val 
                405                 410                 415     


Tyr Lys Lys His Pro His Phe Ala Lys Arg Leu His Lys Thr Val Arg 
            420                 425                 430         


Arg Leu Val Pro Gly Cys Asp Val Arg Phe Leu Arg Ser Glu Asp Gly 
        435                 440                 445             


Ser Gly Lys Gly Ala Ala Met Val Thr Ala Val Ala Tyr Arg Leu Ala 
    450                 455                 460                 


Asp Gln His Arg Ala Arg Gln Lys Thr Leu Glu His Leu Gln Leu Ser 
465                 470                 475                 480 


His Asp Gln Leu Leu Glu Val Lys Arg Arg Met Lys Val Glu Met Glu 
                485                 490                 495     


Arg Gly Leu Ser Lys Glu Thr His Ala Ser Ala Pro Val Lys Met Leu 
            500                 505                 510         


Pro Thr Tyr Val Cys Ala Thr Pro Asp Gly Thr Glu Lys Gly Asp Phe 
        515                 520                 525             


Leu Ala Leu Asp Leu Gly Gly Thr Asn Phe Arg Val Leu Leu Val Arg 
    530                 535                 540                 


Val Arg Asn Gly Lys Trp Gly Gly Val Glu Met His Asn Lys Ile Tyr 
545                 550                 555                 560 


Ala Ile Pro Gln Glu Val Met His Gly Thr Gly Asp Glu Leu Phe Asp 
                565                 570                 575     


His Ile Val Gln Cys Ile Ala Asp Phe Leu Glu Tyr Met Gly Met Lys 
            580                 585                 590         


Gly Val Ser Leu Pro Leu Gly Phe Thr Phe Ser Phe Pro Cys Gln Gln 
        595                 600                 605             


Asn Ser Leu Asp Glu Ser Ile Leu Leu Lys Trp Thr Lys Gly Phe Lys 
    610                 615                 620                 


Ala Ser Gly Cys Glu Gly Glu Asp Val Val Thr Leu Leu Lys Glu Ala 
625                 630                 635                 640 


Ile His Arg Arg Glu Glu Phe Asp Leu Asp Val Val Ala Val Val Asn 
                645                 650                 655     


Asp Thr Val Gly Thr Met Met Thr Cys Gly Phe Glu Asp Pro His Cys 
            660                 665                 670         


Glu Val Gly Leu Ile Val Gly Thr Gly Ser Asn Ala Cys Tyr Met Glu 
        675                 680                 685             


Glu Met Arg Asn Val Glu Leu Val Glu Gly Glu Glu Gly Arg Met Cys 
    690                 695                 700                 


Val Asn Met Glu Trp Gly Ala Phe Gly Asp Asn Gly Cys Leu Asp Asp 
705                 710                 715                 720 


Phe Arg Thr Glu Phe Asp Val Ala Val Asp Glu Leu Ser Leu Asn Pro 
                725                 730                 735     


Gly Lys Gln Arg Phe Glu Lys Met Ile Ser Gly Met Tyr Leu Gly Glu 
            740                 745                 750         


Ile Val Arg Asn Ile Leu Ile Asp Phe Thr Lys Arg Gly Leu Leu Phe 
        755                 760                 765             


Arg Gly Arg Ile Ser Glu Arg Leu Lys Thr Arg Gly Ile Phe Glu Thr 
    770                 775                 780                 


Lys Phe Leu Ser Gln Ile Glu Ser Asp Cys Leu Ala Leu Leu Gln Val 
785                 790                 795                 800 


Arg Ala Ile Leu Gln His Leu Gly Leu Glu Ser Thr Cys Asp Asp Ser 
                805                 810                 815     


Ile Ile Val Lys Glu Val Cys Thr Val Val Ala Arg Arg Ala Ala Gln 
            820                 825                 830         


Leu Cys Gly Ala Gly Met Ala Ala Val Val Asp Arg Ile Arg Glu Asn 
        835                 840                 845             


Arg Gly Leu Asp Ala Leu Lys Val Thr Val Gly Val Asp Gly Thr Leu 
    850                 855                 860                 


Tyr Lys Leu His Pro His Phe Ala Lys Val Met His Glu Thr Val Lys 
865                 870                 875                 880 


Asp Leu Ala Pro Lys Cys Asp Val Ser Phe Leu Gln Ser Glu Asp Gly 
                885                 890                 895     


Ser Gly Lys Gly Ala Ala Leu Ile Thr Ala Val Ala Cys Arg Ile Arg 
            900                 905                 910         


Glu Ala Gly Gln Arg 
        915         


<210>  28
<211>  923
<212>  PRT
<213>  Homo sapiens

<400>  28

Met Asp Ser Ile Gly Ser Ser Gly Leu Arg Gln Gly Glu Glu Thr Leu 
1               5                   10                  15      


Ser Cys Ser Glu Glu Gly Leu Pro Gly Pro Ser Asp Ser Ser Glu Leu 
            20                  25                  30          


Val Gln Glu Cys Leu Gln Gln Phe Lys Val Thr Arg Ala Gln Leu Gln 
        35                  40                  45              


Gln Ile Gln Ala Ser Leu Leu Gly Ser Met Glu Gln Ala Leu Arg Gly 
    50                  55                  60                  


Gln Ala Ser Pro Ala Pro Ala Val Arg Met Leu Pro Thr Tyr Val Gly 
65                  70                  75                  80  


Ser Thr Pro His Gly Thr Glu Gln Gly Asp Phe Val Val Leu Glu Leu 
                85                  90                  95      


Gly Ala Thr Gly Ala Ser Leu Arg Val Leu Trp Val Thr Leu Thr Gly 
            100                 105                 110         


Ile Glu Gly His Arg Val Glu Pro Arg Ser Gln Glu Phe Val Ile Pro 
        115                 120                 125             


Gln Glu Val Met Leu Gly Ala Gly Gln Gln Leu Phe Asp Phe Ala Ala 
    130                 135                 140                 


His Cys Leu Ser Glu Phe Leu Asp Ala Gln Pro Val Asn Lys Gln Gly 
145                 150                 155                 160 


Leu Gln Leu Gly Phe Ser Phe Ser Phe Pro Cys His Gln Thr Gly Leu 
                165                 170                 175     


Asp Arg Ser Thr Leu Ile Ser Trp Thr Lys Gly Phe Arg Cys Ser Gly 
            180                 185                 190         


Val Glu Gly Gln Asp Val Val Gln Leu Leu Arg Asp Ala Ile Arg Arg 
        195                 200                 205             


Gln Gly Ala Tyr Asn Ile Asp Val Val Ala Val Val Asn Asp Thr Val 
    210                 215                 220                 


Gly Thr Met Met Gly Cys Glu Pro Gly Val Arg Pro Cys Glu Val Gly 
225                 230                 235                 240 


Leu Val Val Asp Thr Gly Thr Asn Ala Cys Tyr Met Glu Glu Ala Arg 
                245                 250                 255     


His Val Ala Val Leu Asp Glu Asp Arg Gly Arg Val Cys Val Ser Val 
            260                 265                 270         


Glu Trp Gly Ser Phe Ser Asp Asp Gly Ala Leu Gly Pro Val Leu Thr 
        275                 280                 285             


Thr Phe Asp His Thr Leu Asp His Glu Ser Leu Asn Pro Gly Ala Gln 
    290                 295                 300                 


Arg Phe Glu Lys Met Ile Gly Gly Leu Tyr Leu Gly Glu Leu Val Arg 
305                 310                 315                 320 


Leu Val Leu Ala His Leu Ala Arg Cys Gly Val Leu Phe Gly Gly Cys 
                325                 330                 335     


Thr Ser Pro Ala Leu Leu Ser Gln Gly Ser Ile Leu Leu Glu His Val 
            340                 345                 350         


Ala Glu Met Glu Asp Pro Ser Thr Gly Ala Ala Arg Val His Ala Ile 
        355                 360                 365             


Leu Gln Asp Leu Gly Leu Ser Pro Gly Ala Ser Asp Val Glu Leu Val 
    370                 375                 380                 


Gln His Val Cys Ala Ala Val Cys Thr Arg Ala Ala Gln Leu Cys Ala 
385                 390                 395                 400 


Ala Ala Leu Ala Ala Val Leu Ser Cys Leu Gln His Ser Arg Glu Gln 
                405                 410                 415     


Gln Thr Leu Gln Val Ala Val Ala Thr Gly Gly Arg Val Cys Glu Arg 
            420                 425                 430         


His Pro Arg Phe Cys Ser Val Leu Gln Gly Thr Val Met Leu Leu Ala 
        435                 440                 445             


Pro Glu Cys Asp Val Ser Leu Ile Pro Ser Val Asp Gly Gly Gly Arg 
    450                 455                 460                 


Gly Val Ala Met Val Thr Ala Val Ala Ala Arg Leu Ala Ala His Arg 
465                 470                 475                 480 


Arg Leu Leu Glu Glu Thr Leu Ala Pro Phe Arg Leu Asn His Asp Gln 
                485                 490                 495     


Leu Ala Ala Val Gln Ala Gln Met Arg Lys Ala Met Ala Lys Gly Leu 
            500                 505                 510         


Arg Gly Glu Ala Ser Ser Leu Arg Met Leu Pro Thr Phe Val Arg Ala 
        515                 520                 525             


Thr Pro Asp Gly Ser Glu Arg Gly Asp Phe Leu Ala Leu Asp Leu Gly 
    530                 535                 540                 


Gly Thr Asn Phe Arg Val Leu Leu Val Arg Val Thr Thr Gly Val Gln 
545                 550                 555                 560 


Ile Thr Ser Glu Ile Tyr Ser Ile Pro Glu Thr Val Ala Gln Gly Ser 
                565                 570                 575     


Gly Gln Gln Leu Phe Asp His Ile Val Asp Cys Ile Val Asp Phe Gln 
            580                 585                 590         


Gln Lys Gln Gly Leu Ser Gly Gln Ser Leu Pro Leu Gly Phe Thr Phe 
        595                 600                 605             


Ser Phe Pro Cys Arg Gln Leu Gly Leu Asp Gln Gly Ile Leu Leu Asn 
    610                 615                 620                 


Trp Thr Lys Gly Phe Lys Ala Ser Asp Cys Glu Gly Gln Asp Val Val 
625                 630                 635                 640 


Ser Leu Leu Arg Glu Ala Ile Thr Arg Arg Gln Ala Val Glu Leu Asn 
                645                 650                 655     


Val Val Ala Ile Val Asn Asp Thr Val Gly Thr Met Met Ser Cys Gly 
            660                 665                 670         


Tyr Glu Asp Pro Arg Cys Glu Ile Gly Leu Ile Val Gly Thr Gly Thr 
        675                 680                 685             


Asn Ala Cys Tyr Met Glu Glu Leu Arg Asn Val Ala Gly Val Pro Gly 
    690                 695                 700                 


Asp Ser Gly Arg Met Cys Ile Asn Met Glu Trp Gly Ala Phe Gly Asp 
705                 710                 715                 720 


Asp Gly Ser Leu Ala Met Leu Ser Thr Arg Phe Asp Ala Ser Val Asp 
                725                 730                 735     


Gln Ala Ser Ile Asn Pro Gly Lys Gln Arg Phe Glu Lys Met Ile Ser 
            740                 745                 750         


Gly Met Tyr Leu Gly Glu Ile Val Arg His Ile Leu Leu His Leu Thr 
        755                 760                 765             


Ser Leu Gly Val Leu Phe Arg Gly Gln Gln Ile Gln Arg Leu Gln Thr 
    770                 775                 780                 


Arg Asp Ile Phe Lys Thr Lys Phe Leu Ser Glu Ile Glu Ser Asp Ser 
785                 790                 795                 800 


Leu Ala Leu Arg Gln Val Arg Ala Ile Leu Glu Asp Leu Gly Leu Pro 
                805                 810                 815     


Leu Thr Ser Asp Asp Ala Leu Met Val Leu Glu Val Cys Gln Ala Val 
            820                 825                 830         


Ser Gln Arg Ala Ala Gln Leu Cys Gly Ala Gly Val Ala Ala Val Val 
        835                 840                 845             


Glu Lys Ile Arg Glu Asn Arg Gly Leu Glu Glu Leu Ala Val Ser Val 
    850                 855                 860                 


Gly Val Asp Gly Thr Leu Tyr Lys Leu His Pro Arg Phe Ser Ser Leu 
865                 870                 875                 880 


Val Ala Ala Thr Val Arg Glu Leu Ala Pro Arg Cys Val Val Thr Phe 
                885                 890                 895     


Leu Gln Ser Glu Asp Gly Ser Gly Lys Gly Ala Ala Leu Val Thr Ala 
            900                 905                 910         


Val Ala Cys Arg Leu Ala Gln Leu Thr Arg Val 
        915                 920             


<210>  29
<211>  465
<212>  PRT
<213>  Homo sapiens

<400>  29

Met Leu Asp Asp Arg Ala Arg Met Glu Ala Ala Lys Lys Glu Lys Val 
1               5                   10                  15      


Glu Gln Ile Leu Ala Glu Phe Gln Leu Gln Glu Glu Asp Leu Lys Lys 
            20                  25                  30          


Val Met Arg Arg Met Gln Lys Glu Met Asp Arg Gly Leu Arg Leu Glu 
        35                  40                  45              


Thr His Glu Glu Ala Ser Val Lys Met Leu Pro Thr Tyr Val Arg Ser 
    50                  55                  60                  


Thr Pro Glu Gly Ser Glu Val Gly Asp Phe Leu Ser Leu Asp Leu Gly 
65                  70                  75                  80  


Gly Thr Asn Phe Arg Val Met Leu Val Lys Val Gly Glu Gly Glu Glu 
                85                  90                  95      


Gly Gln Trp Ser Val Lys Thr Lys His Gln Met Tyr Ser Ile Pro Glu 
            100                 105                 110         


Asp Ala Met Thr Gly Thr Ala Glu Met Leu Phe Asp Tyr Ile Ser Glu 
        115                 120                 125             


Cys Ile Ser Asp Phe Leu Asp Lys His Gln Met Lys His Lys Lys Leu 
    130                 135                 140                 


Pro Leu Gly Phe Thr Phe Ser Phe Pro Val Arg His Glu Asp Ile Asp 
145                 150                 155                 160 


Lys Gly Ile Leu Leu Asn Trp Thr Lys Gly Phe Lys Ala Ser Gly Ala 
                165                 170                 175     


Glu Gly Asn Asn Val Val Gly Leu Leu Arg Asp Ala Ile Lys Arg Arg 
            180                 185                 190         


Gly Asp Phe Glu Met Asp Val Val Ala Met Val Asn Asp Thr Val Ala 
        195                 200                 205             


Thr Met Ile Ser Cys Tyr Tyr Glu Asp His Gln Cys Glu Val Gly Met 
    210                 215                 220                 


Ile Val Gly Thr Gly Cys Asn Ala Cys Tyr Met Glu Glu Met Gln Asn 
225                 230                 235                 240 


Val Glu Leu Val Glu Gly Asp Glu Gly Arg Met Cys Val Asn Thr Glu 
                245                 250                 255     


Trp Gly Ala Phe Gly Asp Ser Gly Glu Leu Asp Glu Phe Leu Leu Glu 
            260                 265                 270         


Tyr Asp Arg Leu Val Asp Glu Ser Ser Ala Asn Pro Gly Gln Gln Leu 
        275                 280                 285             


Tyr Glu Lys Leu Ile Gly Gly Lys Tyr Met Gly Glu Leu Val Arg Leu 
    290                 295                 300                 


Val Leu Leu Arg Leu Val Asp Glu Asn Leu Leu Phe His Gly Glu Ala 
305                 310                 315                 320 


Ser Glu Gln Leu Arg Thr Arg Gly Ala Phe Glu Thr Arg Phe Val Ser 
                325                 330                 335     


Gln Val Glu Ser Asp Thr Gly Asp Arg Lys Gln Ile Tyr Asn Ile Leu 
            340                 345                 350         


Ser Thr Leu Gly Leu Arg Pro Ser Thr Thr Asp Cys Asp Ile Val Arg 
        355                 360                 365             


Arg Ala Cys Glu Ser Val Ser Thr Arg Ala Ala His Met Cys Ser Ala 
    370                 375                 380                 


Gly Leu Ala Gly Val Ile Asn Arg Met Arg Glu Ser Arg Ser Glu Asp 
385                 390                 395                 400 


Val Met Arg Ile Thr Val Gly Val Asp Gly Ser Val Tyr Lys Leu His 
                405                 410                 415     


Pro Ser Phe Lys Glu Arg Phe His Ala Ser Val Arg Arg Leu Thr Pro 
            420                 425                 430         


Ser Cys Glu Ile Thr Phe Ile Glu Ser Glu Glu Gly Ser Gly Arg Gly 
        435                 440                 445             


Ala Ala Leu Val Ser Ala Val Ala Cys Lys Lys Ala Cys Met Leu Gly 
    450                 455                 460                 


Gln 
465 


<210>  30
<211>  820
<212>  PRT
<213>  Escherichia coli

<400>  30

Met Arg Val Leu Lys Phe Gly Gly Thr Ser Val Ala Asn Ala Glu Arg 
1               5                   10                  15      


Phe Leu Arg Val Ala Asp Ile Leu Glu Ser Asn Ala Arg Gln Gly Gln 
            20                  25                  30          


Val Ala Thr Val Leu Ser Ala Pro Ala Lys Ile Thr Asn His Leu Val 
        35                  40                  45              


Ala Met Ile Glu Lys Thr Ile Ser Gly Gln Asp Ala Leu Pro Asn Ile 
    50                  55                  60                  


Ser Asp Ala Glu Arg Ile Phe Ala Glu Leu Leu Thr Gly Leu Ala Ala 
65                  70                  75                  80  


Ala Gln Pro Gly Phe Pro Leu Ala Gln Leu Lys Thr Phe Val Asp Gln 
                85                  90                  95      


Glu Phe Ala Gln Ile Lys His Val Leu His Gly Ile Ser Leu Leu Gly 
            100                 105                 110         


Gln Cys Pro Asp Ser Ile Asn Ala Ala Leu Ile Cys Arg Gly Glu Lys 
        115                 120                 125             


Met Ser Ile Ala Ile Met Ala Gly Val Leu Glu Ala Arg Gly His Asn 
    130                 135                 140                 


Val Thr Val Ile Asp Pro Val Glu Lys Leu Leu Ala Val Gly His Tyr 
145                 150                 155                 160 


Leu Glu Ser Thr Val Asp Ile Ala Glu Ser Thr Arg Arg Ile Ala Ala 
                165                 170                 175     


Ser Arg Ile Pro Ala Asp His Met Val Leu Met Ala Gly Phe Thr Ala 
            180                 185                 190         


Gly Asn Glu Lys Gly Glu Leu Val Val Leu Gly Arg Asn Gly Ser Asp 
        195                 200                 205             


Tyr Ser Ala Ala Val Leu Ala Ala Cys Leu Arg Ala Asp Cys Cys Glu 
    210                 215                 220                 


Ile Trp Thr Asp Val Asp Gly Val Tyr Thr Cys Asp Pro Arg Gln Val 
225                 230                 235                 240 


Pro Asp Ala Arg Leu Leu Lys Ser Met Ser Tyr Gln Glu Ala Met Glu 
                245                 250                 255     


Leu Ser Tyr Phe Gly Ala Lys Val Leu His Pro Arg Thr Ile Thr Pro 
            260                 265                 270         


Ile Ala Gln Phe Gln Ile Pro Cys Leu Ile Lys Asn Thr Gly Asn Pro 
        275                 280                 285             


Gln Ala Pro Gly Thr Leu Ile Gly Ala Ser Arg Asp Glu Asp Glu Leu 
    290                 295                 300                 


Pro Val Lys Gly Ile Ser Asn Leu Asn Asn Met Ala Met Phe Ser Val 
305                 310                 315                 320 


Ser Gly Pro Gly Met Lys Gly Met Val Gly Met Ala Ala Arg Val Phe 
                325                 330                 335     


Ala Ala Met Ser Arg Ala Arg Ile Ser Val Val Leu Ile Thr Gln Ser 
            340                 345                 350         


Ser Ser Glu Tyr Ser Ile Ser Phe Cys Val Pro Gln Ser Asp Cys Val 
        355                 360                 365             


Arg Ala Glu Arg Ala Met Gln Glu Glu Phe Tyr Leu Glu Leu Lys Glu 
    370                 375                 380                 


Gly Leu Leu Glu Pro Leu Ala Val Thr Glu Arg Leu Ala Ile Ile Ser 
385                 390                 395                 400 


Val Val Gly Asp Gly Met Arg Thr Leu Arg Gly Ile Ser Ala Lys Phe 
                405                 410                 415     


Phe Ala Ala Leu Ala Arg Ala Asn Ile Asn Ile Val Ala Ile Ala Gln 
            420                 425                 430         


Gly Ser Ser Glu Arg Ser Ile Ser Val Val Val Asn Asn Asp Asp Ala 
        435                 440                 445             


Thr Thr Gly Val Arg Val Thr His Gln Met Leu Phe Asn Thr Asp Gln 
    450                 455                 460                 


Val Ile Glu Val Phe Val Ile Gly Val Gly Gly Val Gly Gly Ala Leu 
465                 470                 475                 480 


Leu Glu Gln Leu Lys Arg Gln Gln Ser Trp Leu Lys Asn Lys His Ile 
                485                 490                 495     


Asp Leu Arg Val Cys Gly Val Ala Asn Ser Lys Ala Leu Leu Thr Asn 
            500                 505                 510         


Val His Gly Leu Asn Leu Glu Asn Trp Gln Glu Glu Leu Ala Gln Ala 
        515                 520                 525             


Lys Glu Pro Phe Asn Leu Gly Arg Leu Ile Arg Leu Val Lys Glu Tyr 
    530                 535                 540                 


His Leu Leu Asn Pro Val Ile Val Asp Cys Thr Ser Ser Gln Ala Val 
545                 550                 555                 560 


Ala Asp Gln Tyr Ala Asp Phe Leu Arg Glu Gly Phe His Val Val Thr 
                565                 570                 575     


Pro Asn Lys Lys Ala Asn Thr Ser Ser Met Asp Tyr Tyr His Gln Leu 
            580                 585                 590         


Arg Tyr Ala Ala Glu Lys Ser Arg Arg Lys Phe Leu Tyr Asp Thr Asn 
        595                 600                 605             


Val Gly Ala Gly Leu Pro Val Ile Glu Asn Leu Gln Asn Leu Leu Asn 
    610                 615                 620                 


Ala Gly Asp Glu Leu Met Lys Phe Ser Gly Ile Leu Ser Gly Ser Leu 
625                 630                 635                 640 


Ser Tyr Ile Phe Gly Lys Leu Asp Glu Gly Met Ser Phe Ser Glu Ala 
                645                 650                 655     


Thr Thr Leu Ala Arg Glu Met Gly Tyr Thr Glu Pro Asp Pro Arg Asp 
            660                 665                 670         


Asp Leu Ser Gly Met Asp Val Ala Arg Lys Leu Leu Ile Leu Ala Arg 
        675                 680                 685             


Glu Thr Gly Arg Glu Leu Glu Leu Ala Asp Ile Glu Ile Glu Pro Val 
    690                 695                 700                 


Leu Pro Ala Glu Phe Asn Ala Glu Gly Asp Val Ala Ala Phe Met Ala 
705                 710                 715                 720 


Asn Leu Ser Gln Leu Asp Asp Leu Phe Ala Ala Arg Val Ala Lys Ala 
                725                 730                 735     


Arg Asp Glu Gly Lys Val Leu Arg Tyr Val Gly Asn Ile Asp Glu Asp 
            740                 745                 750         


Gly Val Cys Arg Val Lys Ile Ala Glu Val Asp Gly Asn Asp Pro Leu 
        755                 760                 765             


Phe Lys Val Lys Asn Gly Glu Asn Ala Leu Ala Phe Tyr Ser His Tyr 
    770                 775                 780                 


Tyr Gln Pro Leu Pro Leu Val Leu Arg Gly Tyr Gly Ala Gly Asn Asp 
785                 790                 795                 800 


Val Thr Ala Ala Gly Val Phe Ala Asp Leu Leu Arg Thr Leu Ser Trp 
                805                 810                 815     


Lys Leu Gly Val 
            820 


<210>  31
<211>  810
<212>  PRT
<213>  Escherichia coli

<400>  31

Met Ser Val Ile Ala Gln Ala Gly Ala Lys Gly Arg Gln Leu His Lys 
1               5                   10                  15      


Phe Gly Gly Ser Ser Leu Ala Asp Val Lys Cys Tyr Leu Arg Val Ala 
            20                  25                  30          


Gly Ile Met Ala Glu Tyr Ser Gln Pro Asp Asp Met Met Val Val Ser 
        35                  40                  45              


Ala Ala Gly Ser Thr Thr Asn Gln Leu Ile Asn Trp Leu Lys Leu Ser 
    50                  55                  60                  


Gln Thr Asp Arg Leu Ser Ala His Gln Val Gln Gln Thr Leu Arg Arg 
65                  70                  75                  80  


Tyr Gln Cys Asp Leu Ile Ser Gly Leu Leu Pro Ala Glu Glu Ala Asp 
                85                  90                  95      


Ser Leu Ile Ser Ala Phe Val Ser Asp Leu Glu Arg Leu Ala Ala Leu 
            100                 105                 110         


Leu Asp Ser Gly Ile Asn Asp Ala Val Tyr Ala Glu Val Val Gly His 
        115                 120                 125             


Gly Glu Val Trp Ser Ala Arg Leu Met Ser Ala Val Leu Asn Gln Gln 
    130                 135                 140                 


Gly Leu Pro Ala Ala Trp Leu Asp Ala Arg Glu Phe Leu Arg Ala Glu 
145                 150                 155                 160 


Arg Ala Ala Gln Pro Gln Val Asp Glu Gly Leu Ser Tyr Pro Leu Leu 
                165                 170                 175     


Gln Gln Leu Leu Val Gln His Pro Gly Lys Arg Leu Val Val Thr Gly 
            180                 185                 190         


Phe Ile Ser Arg Asn Asn Ala Gly Glu Thr Val Leu Leu Gly Arg Asn 
        195                 200                 205             


Gly Ser Asp Tyr Ser Ala Thr Gln Ile Gly Ala Leu Ala Gly Val Ser 
    210                 215                 220                 


Arg Val Thr Ile Trp Ser Asp Val Ala Gly Val Tyr Ser Ala Asp Pro 
225                 230                 235                 240 


Arg Lys Val Lys Asp Ala Cys Leu Leu Pro Leu Leu Arg Leu Asp Glu 
                245                 250                 255     


Ala Ser Glu Leu Ala Arg Leu Ala Ala Pro Val Leu His Ala Arg Thr 
            260                 265                 270         


Leu Gln Pro Val Ser Gly Ser Glu Ile Asp Leu Gln Leu Arg Cys Ser 
        275                 280                 285             


Tyr Thr Pro Asp Gln Gly Ser Thr Arg Ile Glu Arg Val Leu Ala Ser 
    290                 295                 300                 


Gly Thr Gly Ala Arg Ile Val Thr Ser His Asp Asp Val Cys Leu Ile 
305                 310                 315                 320 


Glu Phe Gln Val Pro Ala Ser Gln Asp Phe Lys Leu Ala His Lys Glu 
                325                 330                 335     


Ile Asp Gln Ile Leu Lys Arg Ala Gln Val Arg Pro Leu Ala Val Gly 
            340                 345                 350         


Val His Asn Asp Arg Gln Leu Leu Gln Phe Cys Tyr Thr Ser Glu Val 
        355                 360                 365             


Ala Asp Ser Ala Leu Lys Ile Leu Asp Glu Ala Gly Leu Pro Gly Glu 
    370                 375                 380                 


Leu Arg Leu Arg Gln Gly Leu Ala Leu Val Ala Met Val Gly Ala Gly 
385                 390                 395                 400 


Val Thr Arg Asn Pro Leu His Cys His Arg Phe Trp Gln Gln Leu Lys 
                405                 410                 415     


Gly Gln Pro Val Glu Phe Thr Trp Gln Ser Asp Asp Gly Ile Ser Leu 
            420                 425                 430         


Val Ala Val Leu Arg Thr Gly Pro Thr Glu Ser Leu Ile Gln Gly Leu 
        435                 440                 445             


His Gln Ser Val Phe Arg Ala Glu Lys Arg Ile Gly Leu Val Leu Phe 
    450                 455                 460                 


Gly Lys Gly Asn Ile Gly Ser Arg Trp Leu Glu Leu Phe Ala Arg Glu 
465                 470                 475                 480 


Gln Ser Thr Leu Ser Ala Arg Thr Gly Phe Glu Phe Val Leu Ala Gly 
                485                 490                 495     


Val Val Asp Ser Arg Arg Ser Leu Leu Ser Tyr Asp Gly Leu Asp Ala 
            500                 505                 510         


Ser Arg Ala Leu Ala Phe Phe Asn Asp Glu Ala Val Glu Gln Asp Glu 
        515                 520                 525             


Glu Ser Leu Phe Leu Trp Met Arg Ala His Pro Tyr Asp Asp Leu Val 
    530                 535                 540                 


Val Leu Asp Val Thr Ala Ser Gln Gln Leu Ala Asp Gln Tyr Leu Asp 
545                 550                 555                 560 


Phe Ala Ser His Gly Phe His Val Ile Ser Ala Asn Lys Leu Ala Gly 
                565                 570                 575     


Ala Ser Asp Ser Asn Lys Tyr Arg Gln Ile His Asp Ala Phe Glu Lys 
            580                 585                 590         


Thr Gly Arg His Trp Leu Tyr Asn Ala Thr Val Gly Ala Gly Leu Pro 
        595                 600                 605             


Ile Asn His Thr Val Arg Asp Leu Ile Asp Ser Gly Asp Thr Ile Leu 
    610                 615                 620                 


Ser Ile Ser Gly Ile Phe Ser Gly Thr Leu Ser Trp Leu Phe Leu Gln 
625                 630                 635                 640 


Phe Asp Gly Ser Val Pro Phe Thr Glu Leu Val Asp Gln Ala Trp Gln 
                645                 650                 655     


Gln Gly Leu Thr Glu Pro Asp Pro Arg Asp Asp Leu Ser Gly Lys Asp 
            660                 665                 670         


Val Met Arg Lys Leu Val Ile Leu Ala Arg Glu Ala Gly Tyr Asn Ile 
        675                 680                 685             


Glu Pro Asp Gln Val Arg Val Glu Ser Leu Val Pro Ala His Cys Glu 
    690                 695                 700                 


Gly Gly Ser Ile Asp His Phe Phe Glu Asn Gly Asp Glu Leu Asn Glu 
705                 710                 715                 720 


Gln Met Val Gln Arg Leu Glu Ala Ala Arg Glu Met Gly Leu Val Leu 
                725                 730                 735     


Arg Tyr Val Ala Arg Phe Asp Ala Asn Gly Lys Ala Arg Val Gly Val 
            740                 745                 750         


Glu Ala Val Arg Glu Asp His Pro Leu Ala Ser Leu Leu Pro Cys Asp 
        755                 760                 765             


Asn Val Phe Ala Ile Glu Ser Arg Trp Tyr Arg Asp Asn Pro Leu Val 
    770                 775                 780                 


Ile Arg Gly Pro Gly Ala Gly Arg Asp Val Thr Ala Gly Ala Ile Gln 
785                 790                 795                 800 


Ser Asp Ile Asn Arg Leu Ala Gln Leu Leu 
                805                 810 


<210>  32
<211>  449
<212>  PRT
<213>  Escherichia coli

<400>  32

Met Ser Glu Ile Val Val Ser Lys Phe Gly Gly Thr Ser Val Ala Asp 
1               5                   10                  15      


Phe Asp Ala Met Asn Arg Ser Ala Asp Ile Val Leu Ser Asp Ala Asn 
            20                  25                  30          


Val Arg Leu Val Val Leu Ser Ala Ser Ala Gly Ile Thr Asn Leu Leu 
        35                  40                  45              


Val Ala Leu Ala Glu Gly Leu Glu Pro Gly Glu Arg Phe Glu Lys Leu 
    50                  55                  60                  


Asp Ala Ile Arg Asn Ile Gln Phe Ala Ile Leu Glu Arg Leu Arg Tyr 
65                  70                  75                  80  


Pro Asn Val Ile Arg Glu Glu Ile Glu Arg Leu Leu Glu Asn Ile Thr 
                85                  90                  95      


Val Leu Ala Glu Ala Ala Ala Leu Ala Thr Ser Pro Ala Leu Thr Asp 
            100                 105                 110         


Glu Leu Val Ser His Gly Glu Leu Met Ser Thr Leu Leu Phe Val Glu 
        115                 120                 125             


Ile Leu Arg Glu Arg Asp Val Gln Ala Gln Trp Phe Asp Val Arg Lys 
    130                 135                 140                 


Val Met Arg Thr Asn Asp Arg Phe Gly Arg Ala Glu Pro Asp Ile Ala 
145                 150                 155                 160 


Ala Leu Ala Glu Leu Ala Ala Leu Gln Leu Leu Pro Arg Leu Asn Glu 
                165                 170                 175     


Gly Leu Val Ile Thr Gln Gly Phe Ile Gly Ser Glu Asn Lys Gly Arg 
            180                 185                 190         


Thr Thr Thr Leu Gly Arg Gly Gly Ser Asp Tyr Thr Ala Ala Leu Leu 
        195                 200                 205             


Ala Glu Ala Leu His Ala Ser Arg Val Asp Ile Trp Thr Asp Val Pro 
    210                 215                 220                 


Gly Ile Tyr Thr Thr Asp Pro Arg Val Val Ser Ala Ala Lys Arg Ile 
225                 230                 235                 240 


Asp Glu Ile Ala Phe Ala Glu Ala Ala Glu Met Ala Thr Phe Gly Ala 
                245                 250                 255     


Lys Val Leu His Pro Ala Thr Leu Leu Pro Ala Val Arg Ser Asp Ile 
            260                 265                 270         


Pro Val Phe Val Gly Ser Ser Lys Asp Pro Arg Ala Gly Gly Thr Leu 
        275                 280                 285             


Val Cys Asn Lys Thr Glu Asn Pro Pro Leu Phe Arg Ala Leu Ala Leu 
    290                 295                 300                 


Arg Arg Asn Gln Thr Leu Leu Thr Leu His Ser Leu Asn Met Leu His 
305                 310                 315                 320 


Ser Arg Gly Phe Leu Ala Glu Val Phe Gly Ile Leu Ala Arg His Asn 
                325                 330                 335     


Ile Ser Val Asp Leu Ile Thr Thr Ser Glu Val Ser Val Ala Leu Thr 
            340                 345                 350         


Leu Asp Thr Thr Gly Ser Thr Ser Thr Gly Asp Thr Leu Leu Thr Gln 
        355                 360                 365             


Ser Leu Leu Met Glu Leu Ser Ala Leu Cys Arg Val Glu Val Glu Glu 
    370                 375                 380                 


Gly Leu Ala Leu Val Ala Leu Ile Gly Asn Asp Leu Ser Lys Ala Cys 
385                 390                 395                 400 


Gly Val Gly Lys Glu Val Phe Gly Val Leu Glu Pro Phe Asn Ile Arg 
                405                 410                 415     


Met Ile Cys Tyr Gly Ala Ser Ser His Asn Leu Cys Phe Leu Val Pro 
            420                 425                 430         


Gly Glu Asp Ala Glu Gln Val Val Gln Lys Leu His Ser Asn Leu Phe 
        435                 440                 445             


Glu 
    


<210>  33
<211>  468
<212>  PRT
<213>  Salmonella typhimurium

<400>  33

Ser Ala Glu His Val Leu Thr Met Leu Asn Glu His Glu Val Lys Phe 
1               5                   10                  15      


Val Asp Leu Arg Phe Thr Asp Thr Lys Gly Lys Glu Gln His Val Thr 
            20                  25                  30          


Ile Pro Ala His Gln Val Asn Ala Glu Phe Phe Glu Glu Gly Lys Met 
        35                  40                  45              


Phe Asp Gly Ser Ser Ile Gly Gly Trp Lys Gly Ile Asn Glu Ser Asp 
    50                  55                  60                  


Met Val Leu Met Pro Asp Ala Ser Thr Ala Val Ile Asp Pro Phe Phe 
65                  70                  75                  80  


Ala Asp Ser Thr Leu Ile Ile Arg Cys Asp Ile Leu Glu Pro Gly Thr 
                85                  90                  95      


Leu Gln Gly Tyr Asp Arg Asp Pro Arg Ser Ile Ala Lys Arg Ala Glu 
            100                 105                 110         


Asp Tyr Leu Arg Ala Thr Gly Ile Ala Asp Thr Val Leu Phe Gly Pro 
        115                 120                 125             


Glu Pro Glu Phe Phe Leu Phe Asp Asp Ile Arg Phe Gly Ala Ser Ile 
    130                 135                 140                 


Ser Gly Ser His Val Ala Ile Asp Asp Ile Glu Gly Ala Trp Asn Ser 
145                 150                 155                 160 


Ser Thr Lys Tyr Glu Gly Gly Asn Lys Gly His Arg Pro Gly Val Lys 
                165                 170                 175     


Gly Gly Tyr Phe Pro Val Pro Pro Val Asp Ser Ala Gln Asp Ile Arg 
            180                 185                 190         


Ser Glu Met Cys Leu Val Met Glu Gln Met Gly Leu Val Val Glu Ala 
        195                 200                 205             


His His His Glu Val Ala Thr Ala Gly Gln Asn Glu Val Ala Thr Arg 
    210                 215                 220                 


Phe Asn Thr Met Thr Lys Lys Ala Asp Glu Ile Gln Ile Tyr Lys Tyr 
225                 230                 235                 240 


Val Val His Asn Val Ala His Arg Phe Gly Lys Thr Ala Thr Phe Met 
                245                 250                 255     


Pro Lys Pro Met Phe Gly Asp Asn Gly Ser Gly Met His Cys His Met 
            260                 265                 270         


Ser Leu Ala Lys Asn Gly Thr Asn Leu Phe Ser Gly Asp Lys Tyr Ala 
        275                 280                 285             


Gly Leu Ser Glu Gln Ala Leu Tyr Tyr Ile Gly Gly Val Ile Lys His 
    290                 295                 300                 


Ala Lys Ala Ile Asn Ala Leu Ala Asn Pro Thr Thr Asn Ser Tyr Lys 
305                 310                 315                 320 


Arg Leu Val Pro Gly Tyr Glu Ala Pro Val Met Leu Ala Tyr Ser Ala 
                325                 330                 335     


Arg Asn Arg Ser Ala Ser Ile Arg Ile Pro Val Val Ala Ser Pro Lys 
            340                 345                 350         


Ala Arg Arg Ile Glu Val Arg Phe Pro Asp Pro Ala Ala Asn Pro Tyr 
        355                 360                 365             


Leu Cys Phe Ala Ala Leu Leu Met Ala Gly Leu Asp Gly Ile Lys Asn 
    370                 375                 380                 


Lys Ile His Pro Gly Glu Pro Met Asp Lys Asn Leu Tyr Asp Leu Pro 
385                 390                 395                 400 


Pro Glu Glu Ala Lys Glu Ile Pro Gln Val Ala Gly Ser Leu Glu Glu 
                405                 410                 415     


Ala Leu Asn Ala Leu Asp Leu Asp Arg Glu Phe Leu Lys Ala Gly Gly 
            420                 425                 430         


Val Phe Thr Asp Glu Ala Ile Asp Ala Tyr Ile Ala Leu Arg Arg Glu 
        435                 440                 445             


Glu Asp Asp Arg Val Arg Met Thr Pro His Pro Val Glu Phe Glu Leu 
    450                 455                 460                 


Tyr Tyr Ser Val 
465             


<210>  34
<211>  468
<212>  PRT
<213>  Acidimicrobium ferrooxidans

<400>  34

Met Gly Tyr Ser Pro Ser Asp Val Val Lys Leu Ile Gln Glu Lys Asp 
1               5                   10                  15      


Ile Lys Phe Ile Asp Phe Arg Phe Thr Asp Thr Lys Gly Lys Glu Gln 
            20                  25                  30          


His Val Ser Val Pro Gly His Val Ile Glu Glu Asp Thr Phe Thr Glu 
        35                  40                  45              


Gly Lys Ala Phe Asp Gly Ser Ser Ile Ala Gly Trp Lys Gly Ile Asn 
    50                  55                  60                  


Glu Ser Asp Met Ile Leu Leu Pro Asp Pro Asp Ser Ala Val Leu Asp 
65                  70                  75                  80  


Pro Phe Met Asp Glu Thr Thr Leu Leu Leu Arg Cys Asp Val Ile Glu 
                85                  90                  95      


Pro Ala Thr Gly Gln Gly Tyr Glu Arg Asp Pro Arg Ser Val Ala Lys 
            100                 105                 110         


Arg Ala Glu Ile Tyr Leu Lys Ser Thr Gly Ile Ala Asp Thr Ser Phe 
        115                 120                 125             


Phe Gly Pro Glu Phe Phe Val Phe Asp Ser Val Thr Trp Asn Ile Asp 
    130                 135                 140                 


Met Ser Gly Cys Ala Tyr Lys Val Asp Ala Glu Glu Ala Ala Trp Asn 
145                 150                 155                 160 


Ser Gly Lys Glu Tyr Glu Ser Gly Asn Met Gly His Arg Leu Gly Val 
                165                 170                 175     


Lys Gly Gly Tyr Phe Pro Val Pro Pro Val Asp Ser Ala Gln Asp Leu 
            180                 185                 190         


Arg Ser Ala Met Cys Leu Ala Met Glu Glu Met Gly Leu Lys Val Glu 
        195                 200                 205             


Val His His His Glu Val Ala Thr Ala Gly Gln His Glu Ile Gly Val 
    210                 215                 220                 


Gly Phe Asn Thr Leu Thr Pro Arg Arg Met Arg Cys Lys Ile Leu Lys 
225                 230                 235                 240 


Tyr Val Val His Asn Val Ala Ala Val Arg Gln Thr Ala Thr Phe Met 
                245                 250                 255     


Pro Lys Pro Val Val Gly Asp Asn Gly Ser Gly Met His Val His Gln 
            260                 265                 270         


Ser Leu Gly Lys Asp Gly Lys Asn Ile Phe Ala Gly Asp Leu Tyr Gly 
        275                 280                 285             


Gly Leu Ser Glu Ile Ala Leu Tyr Tyr Ile Gly Gly Ile Ile Lys His 
    290                 295                 300                 


Ala Lys Ala Val Asn Ala Leu Thr Asn Pro Ser Thr Asn Ser Tyr Lys 
305                 310                 315                 320 


Arg Leu Val Pro His Phe Glu Ala Pro Val Leu Leu Ala Tyr Ser Ala 
                325                 330                 335     


Lys Asn Arg Ser Ala Ser Ile Arg Ile Pro Tyr Val Asn Ser Pro Lys 
            340                 345                 350         


Ala Arg Arg Ile Glu Val Arg Phe Pro Asp Ser Thr Ala Asn Pro Tyr 
        355                 360                 365             


Leu Ala Phe Ser Ala Met Leu Met Ala Gly Leu Asp Gly Ile Gln Asn 
    370                 375                 380                 


Lys Ile His Pro Ala Thr Ala Met Asp Lys Asn Leu Tyr Asp Leu Pro 
385                 390                 395                 400 


Ala Glu Glu Gln Ala Asn Ile Pro Gly Val Ala Ala Ser Leu Glu Glu 
                405                 410                 415     


Ala Leu Arg Ala Leu Glu Ala Asp His Asp Phe Leu Met Lys Gly Gly 
            420                 425                 430         


Val Phe Ser Glu Ser Trp Leu Glu Gly Tyr Leu Asp Val Lys Trp Ala 
        435                 440                 445             


Glu Val Gln Thr Leu Arg Val Thr Thr His Pro Val Glu Phe Gln Met 
    450                 455                 460                 


Tyr Tyr Ser Leu 
465             


<210>  35
<211>  468
<212>  PRT
<213>  Escherichia coli

<400>  35

Ser Ala Glu His Val Leu Thr Met Leu Asn Glu His Glu Val Lys Phe 
1               5                   10                  15      


Val Asp Leu Arg Phe Thr Asp Thr Lys Gly Lys Glu Gln His Val Thr 
            20                  25                  30          


Ile Pro Ala His Gln Val Asn Ala Glu Phe Phe Glu Glu Gly Lys Met 
        35                  40                  45              


Phe Asp Gly Ser Ser Ile Gly Gly Trp Lys Gly Ile Asn Glu Ser Asp 
    50                  55                  60                  


Met Val Leu Met Pro Asp Ala Ser Thr Ala Val Ile Asp Pro Phe Phe 
65                  70                  75                  80  


Ala Asp Ser Thr Leu Ile Ile Arg Cys Asp Ile Leu Glu Pro Gly Thr 
                85                  90                  95      


Leu Gln Gly Tyr Asp Arg Asp Pro Arg Ser Ile Ala Lys Arg Ala Glu 
            100                 105                 110         


Asp Tyr Leu Arg Ser Thr Gly Ile Ala Asp Thr Val Leu Phe Gly Pro 
        115                 120                 125             


Glu Pro Glu Phe Phe Leu Phe Asp Asp Ile Arg Phe Gly Ser Ser Ile 
    130                 135                 140                 


Ser Gly Ser His Val Ala Ile Asp Asp Ile Glu Gly Ala Trp Asn Ser 
145                 150                 155                 160 


Ser Thr Gln Tyr Glu Gly Gly Asn Lys Gly His Arg Pro Ala Val Lys 
                165                 170                 175     


Gly Gly Tyr Phe Pro Val Pro Pro Val Asp Ser Ala Gln Asp Ile Arg 
            180                 185                 190         


Ser Glu Met Cys Leu Val Met Glu Gln Met Gly Leu Val Val Glu Ala 
        195                 200                 205             


His His His Glu Val Ala Thr Ala Gly Gln Asn Glu Val Ala Thr Arg 
    210                 215                 220                 


Phe Asn Thr Met Thr Lys Lys Ala Asp Glu Ile Gln Ile Tyr Lys Tyr 
225                 230                 235                 240 


Val Val His Asn Val Ala His Arg Phe Gly Lys Thr Ala Thr Phe Met 
                245                 250                 255     


Pro Lys Pro Met Phe Gly Asp Asn Gly Ser Gly Met His Cys His Met 
            260                 265                 270         


Ser Leu Ser Lys Asn Gly Val Asn Leu Phe Ala Gly Asp Lys Tyr Ala 
        275                 280                 285             


Gly Leu Ser Glu Gln Ala Leu Tyr Tyr Ile Gly Gly Val Ile Lys His 
    290                 295                 300                 


Ala Lys Ala Ile Asn Ala Leu Ala Asn Pro Thr Thr Asn Ser Tyr Lys 
305                 310                 315                 320 


Arg Leu Val Pro Gly Tyr Glu Ala Pro Val Met Leu Ala Tyr Ser Ala 
                325                 330                 335     


Arg Asn Arg Ser Ala Ser Ile Arg Ile Pro Val Val Ser Ser Pro Lys 
            340                 345                 350         


Ala Arg Arg Ile Glu Val Arg Phe Pro Asp Pro Ala Ala Asn Pro Tyr 
        355                 360                 365             


Leu Cys Phe Ala Ala Leu Leu Met Ala Gly Leu Asp Gly Ile Lys Asn 
    370                 375                 380                 


Lys Ile His Pro Gly Glu Ala Met Asp Lys Asn Leu Tyr Asp Leu Pro 
385                 390                 395                 400 


Pro Glu Glu Ala Lys Glu Ile Pro Gln Val Ala Gly Ser Leu Glu Glu 
                405                 410                 415     


Ala Leu Asn Glu Leu Asp Leu Asp Arg Glu Phe Leu Lys Ala Gly Gly 
            420                 425                 430         


Val Phe Thr Asp Glu Ala Ile Asp Ala Tyr Ile Ala Leu Arg Arg Glu 
        435                 440                 445             


Glu Asp Asp Arg Val Arg Met Thr Pro His Pro Val Glu Phe Glu Leu 
    450                 455                 460                 


Tyr Tyr Ser Val 
465             


<210>  36
<211>  491
<212>  PRT
<213>  Archaeoglobus fulgidus

<400>  36

Met Val Arg Arg Leu Arg Gly Asp Cys Met Glu Glu Val Glu Arg Ala 
1               5                   10                  15      


Lys Ala Val Leu Lys Glu Asn Asn Val Arg Gln Val Leu Cys Ala Phe 
            20                  25                  30          


Ala Asp Val Arg Gly Tyr Leu Gln Met Phe Ser Ile Pro Ala Arg Glu 
        35                  40                  45              


Phe Val Asp Gly Ser Ala Phe Glu Asn Gly Ile Gly Phe Asp Gly Ser 
    50                  55                  60                  


Ser Val Arg Gly Phe Arg Thr Ile Glu Lys Ser Asp Met Val Trp Met 
65                  70                  75                  80  


Pro Asp Ala Ser Ser Leu Lys Ile Ile Pro Trp Ile Asp Asp Pro Ile 
                85                  90                  95      


Gln Lys Ser Ala Ile Met Phe Gly Asn Val Tyr Glu Ala Trp Gly Thr 
            100                 105                 110         


Glu Ile Ala Asp Cys Asp Pro Arg Gly Tyr Val Ala Lys Arg Tyr Glu 
        115                 120                 125             


Asp Met Leu Lys Ser Glu Gly Met Ser Ala Ile Phe Gly Pro Glu Ile 
    130                 135                 140                 


Glu Phe Phe Leu Phe Glu Gly Val Asp Phe Thr Arg Leu Ser Trp Asp 
145                 150                 155                 160 


Met Trp Val Ser Pro Asn Gly Gly Ala Gly Asp Ser Trp Gly Pro Pro 
                165                 170                 175     


Arg Ile Met Pro Ile Ser Ser Glu Leu Glu Ser Gly Tyr Met Ile Arg 
            180                 185                 190         


Pro Lys Glu Gly Tyr Phe Arg Pro Pro Pro Glu Asp Thr Thr Val Glu 
        195                 200                 205             


Tyr Arg Asn Glu Leu Val Tyr Tyr Leu Glu Gln Leu Gly Ile Asp Ile 
    210                 215                 220                 


Glu Tyr His His His Glu Val Ala Thr Ala Gly Gln Val Glu Leu Asp 
225                 230                 235                 240 


Phe Lys Pro Lys Gln Leu Val Asp Val Gly Asp Ala Phe Tyr Leu Tyr 
                245                 250                 255     


Lys Phe Ala Ala Lys Asn Ile Ala Ala Met His Gly Leu Tyr Ala Thr 
            260                 265                 270         


Phe Met Pro Lys Pro Leu Tyr Leu Asp Asn Ala Ser Gly Met His Thr 
        275                 280                 285             


His Gln Ser Leu Trp Lys Gly Glu Pro Phe Ser Gly Glu Ala Val Phe 
    290                 295                 300                 


Ala Asp Pro Asp Asp Glu Tyr Met Leu Ser Gln Lys Ala Arg Tyr Tyr 
305                 310                 315                 320 


Ile Gly Gly Leu Leu Glu His Ala Lys Ala Leu Thr Ala Leu Cys Ala 
                325                 330                 335     


Pro Thr Val Asn Ser Tyr Lys Arg Leu Val Pro Gly Phe Glu Ala Pro 
            340                 345                 350         


Ile Tyr Ile Cys Trp Ser Pro Arg Asn Arg Ser Ala Leu Val Arg Val 
        355                 360                 365             


Pro Met Tyr Val Lys Lys Pro Ser Ala Ile Arg Val Glu Tyr Arg Gly 
    370                 375                 380                 


Val Asp Pro Ser Cys Asn Pro Tyr Leu Ala Ile Thr Ala Gln Leu Ala 
385                 390                 395                 400 


Ala Gly Leu Asp Gly Ile Lys Lys Lys Ile Asp Pro Gly Asp Pro Leu 
                405                 410                 415     


Leu Glu Asp Val Tyr Glu Leu Thr Pro Ala Gln Lys Arg Glu Leu Gly 
            420                 425                 430         


Val Gly Glu Leu Pro Thr Thr Leu Arg Asp Ala Ile Asp His Leu Ala 
        435                 440                 445             


Ser Asp Glu Leu Met Gln Glu Val Leu Gly Ser His Ile Phe Asp Ala 
    450                 455                 460                 


Phe Met Glu Leu Lys Ile Asp Glu Trp Asn Gln Tyr Cys Leu Tyr Ile 
465                 470                 475                 480 


Thr Pro Trp Glu Phe Met Lys Tyr Phe Asp Ile 
                485                 490     


<210>  37
<211>  467
<212>  PRT
<213>  Azotobacter vinelandii

<400>  37

Met Ser Lys Ser Leu Gln Leu Ile Lys Glu His Asp Val Lys Trp Ile 
1               5                   10                  15      


Asp Leu Arg Phe Thr Asp Thr Lys Gly Lys Gln Gln His Val Thr Met 
            20                  25                  30          


Pro Ala Arg Asp Val Asp Asp Asp Phe Phe Glu Tyr Gly Lys Met Phe 
        35                  40                  45              


Asp Gly Ser Ser Ile Ala Gly Trp Lys Gly Ile Glu Ala Ser Asp Met 
    50                  55                  60                  


Ile Leu Met Pro Asp Asp Ser Thr Ala Val Leu Asp Pro Phe Thr Glu 
65                  70                  75                  80  


Glu Pro Thr Leu Ile Ile Val Cys Asp Ile Ile Glu Pro Ser Thr Met 
                85                  90                  95      


Gln Gly Tyr Asp Arg Asp Pro Arg Ala Ile Ala Arg Arg Ala Glu Glu 
            100                 105                 110         


Tyr Leu Lys Ser Thr Gly Ile Gly Asp Thr Ala Phe Phe Gly Pro Glu 
        115                 120                 125             


Pro Glu Phe Phe Ile Phe Asp Glu Val Lys Tyr Lys Ser Asp Ile Ser 
    130                 135                 140                 


Gly Ser Met Phe Lys Ile Phe Ser Glu Gln Ala Ala Trp Asn Thr Asp 
145                 150                 155                 160 


Ala Asp Phe Glu Gly Gly Asn Lys Gly His Arg Pro Gly Val Lys Gly 
                165                 170                 175     


Gly Tyr Phe Pro Val Pro Pro Val Asp His Asp His Glu Ile Arg Thr 
            180                 185                 190         


Ala Met Cys Asn Ala Leu Glu Glu Met Gly Leu Lys Val Glu Val His 
        195                 200                 205             


His His Glu Val Ala Thr Ala Gly Gln Asn Glu Ile Gly Val Ser Phe 
    210                 215                 220                 


Asn Thr Leu Val Ala Lys Ala Asp Glu Val Gln Thr Leu Lys Tyr Cys 
225                 230                 235                 240 


Val His Asn Val Ala Asp Ala Tyr Gly Lys Thr Val Thr Phe Met Pro 
                245                 250                 255     


Lys Pro Leu Tyr Gly Asp Asn Gly Ser Gly Met His Val His Met Ser 
            260                 265                 270         


Ile Ala Lys Asp Gly Lys Asn Thr Phe Ala Gly Glu Gly Tyr Ala Gly 
        275                 280                 285             


Leu Ser Asp Thr Ala Leu Tyr Phe Ile Gly Gly Ile Ile Lys His Gly 
    290                 295                 300                 


Lys Ala Leu Asn Gly Phe Thr Asn Pro Ser Thr Asn Ser Tyr Lys Arg 
305                 310                 315                 320 


Leu Val Pro Gly Phe Glu Ala Pro Val Met Leu Ala Tyr Ser Ala Arg 
                325                 330                 335     


Asn Arg Ser Ala Ser Ile Arg Ile Pro Tyr Val Asn Ser Pro Lys Ala 
            340                 345                 350         


Arg Arg Ile Glu Ala Arg Phe Pro Asp Pro Ser Ala Asn Pro Tyr Leu 
        355                 360                 365             


Ala Phe Ala Ala Leu Leu Met Ala Gly Leu Asp Gly Ile Gln Asn Lys 
    370                 375                 380                 


Ile His Pro Gly Asp Ala Ala Asp Lys Asn Leu Tyr Asp Leu Pro Pro 
385                 390                 395                 400 


Glu Glu Ala Lys Glu Ile Pro Gln Val Cys Gly Ser Leu Lys Glu Ala 
                405                 410                 415     


Leu Glu Glu Leu Asp Lys Gly Arg Ala Phe Leu Thr Lys Gly Gly Val 
            420                 425                 430         


Phe Ser Asp Asp Phe Ile Asp Ala Tyr Leu Glu Leu Lys Ser Glu Glu 
        435                 440                 445             


Glu Ile Lys Val Arg Thr Phe Val His Pro Leu Glu Tyr Asp Leu Tyr 
    450                 455                 460                 


Tyr Ser Val 
465         


<210>  38
<211>  443
<212>  PRT
<213>  Bacillus cereus

<400>  38

Ala Arg Tyr Thr Lys Glu Asp Ile Phe Arg Leu Ala Lys Glu Glu Asn 
1               5                   10                  15      


Val Lys Tyr Ile Arg Leu Gln Phe Thr Asp Leu Leu Gly Val Ile Lys 
            20                  25                  30          


Asn Val Glu Ile Pro Val Ser Gln Leu Thr Lys Ala Leu Asp Asn Lys 
        35                  40                  45              


Met Met Phe Asp Gly Ser Ser Ile Glu Gly Phe Val Arg Ile Glu Glu 
    50                  55                  60                  


Ser Asp Met Tyr Leu Tyr Pro Asp Leu Asp Thr Trp Val Ile Phe Pro 
65                  70                  75                  80  


Trp Thr Ala Glu Lys Gly Lys Val Ala Arg Leu Ile Cys Asp Ile Tyr 
                85                  90                  95      


Asn Ala Asp Gly Thr Pro Phe Glu Gly Asp Pro Arg Asn Asn Leu Lys 
            100                 105                 110         


Arg Val Leu Lys Glu Met Glu Ala Leu Gly Phe Ser Asp Phe Asn Leu 
        115                 120                 125             


Gly Pro Glu Pro Glu Phe Phe Leu Phe Lys Val Asp Glu Lys Gly Asn 
    130                 135                 140                 


Pro Thr Leu Glu Leu Asn Asp Asn Gly Gly Tyr Phe Asp Leu Ala Pro 
145                 150                 155                 160 


Met Asp Leu Gly Glu Asn Cys Arg Arg Asp Ile Val Leu Glu Leu Glu 
                165                 170                 175     


Glu Met Gly Phe Glu Ile Glu Ala Ser His His Glu Val Ala Pro Gly 
            180                 185                 190         


Gln His Glu Ile Asp Phe Lys Tyr Ala Asn Ala Ile Arg Ser Cys Asp 
        195                 200                 205             


Asp Ile Gln Thr Phe Lys Leu Val Val Lys Thr Ile Ala Arg Lys His 
    210                 215                 220                 


Gly Leu His Ala Thr Phe Met Pro Lys Pro Leu Tyr Gly Val Asn Gly 
225                 230                 235                 240 


Ser Gly Met His Cys Asn Leu Ser Leu Phe Lys Asn Gly Glu Asn Val 
                245                 250                 255     


Phe Tyr Asp Gln Asn Gly Asp Leu Gln Leu Ser Asp Asp Ala Arg His 
            260                 265                 270         


Phe Ile Ala Gly Ile Leu Lys His Ala Pro Ala Phe Thr Ala Val Ala 
        275                 280                 285             


Asn Pro Thr Val Asn Ser Tyr Lys Arg Leu Val Pro Gly Tyr Glu Ala 
    290                 295                 300                 


Pro Cys Tyr Val Ala Trp Ser Ala Gln Asn Arg Ser Pro Leu Val Arg 
305                 310                 315                 320 


Ile Pro Ala Ser Arg Gly Ile Ser Thr Arg Val Glu Val Arg Ser Val 
                325                 330                 335     


Asp Pro Ala Ala Asn Pro Tyr Leu Val Met Ala Thr Leu Leu Ala Ala 
            340                 345                 350         


Gly Leu Asp Gly Ile Lys Asn Lys Leu Thr Pro Pro Ala Ala Val Asp 
        355                 360                 365             


Arg Asn Ile Tyr Val Met Thr Lys Glu Glu Arg Glu Glu Ala Gly Ile 
    370                 375                 380                 


Val Asp Leu Pro Ala Thr Leu Ala Gln Ala Leu Val Thr Leu Gln Ser 
385                 390                 395                 400 


Asn Glu Val Ile Ser Asn Ala Leu Gly Asp His Leu Leu Glu His Phe 
                405                 410                 415     


Ile Glu Ala Lys Glu Phe Glu Trp Asp Ile Phe Arg Thr Gln Val His 
            420                 425                 430         


Gln Trp Glu Arg Asp Gln Tyr Met Ser Leu Tyr 
        435                 440             


<210>  39
<211>  443
<212>  PRT
<213>  Bacillus subtilis

<400>  39

Ala Lys Tyr Thr Arg Glu Asp Ile Glu Lys Leu Val Lys Glu Glu Asn 
1               5                   10                  15      


Val Lys Tyr Ile Arg Leu Gln Phe Thr Asp Ile Leu Gly Thr Ile Lys 
            20                  25                  30          


Asn Val Glu Ile Pro Val Ser Gln Leu Gly Lys Ala Leu Asp Asn Lys 
        35                  40                  45              


Val Met Phe Asp Gly Ser Ser Ile Glu Gly Phe Val Arg Ile Glu Glu 
    50                  55                  60                  


Ser Asp Met Tyr Leu Tyr Pro Asp Leu Asn Thr Phe Val Ile Phe Pro 
65                  70                  75                  80  


Trp Thr Ala Glu Lys Gly Lys Val Ala Arg Phe Ile Cys Asp Ile Tyr 
                85                  90                  95      


Asn Pro Asp Gly Thr Pro Phe Glu Gly Asp Pro Arg Asn Asn Leu Lys 
            100                 105                 110         


Arg Ile Leu Lys Glu Met Glu Asp Leu Gly Phe Ser Asp Phe Asn Leu 
        115                 120                 125             


Gly Pro Glu Pro Glu Phe Phe Leu Phe Lys Leu Asp Glu Lys Gly Glu 
    130                 135                 140                 


Pro Thr Leu Glu Leu Asn Asp Lys Gly Gly Tyr Phe Asp Leu Ala Pro 
145                 150                 155                 160 


Thr Asp Leu Gly Glu Asn Cys Arg Arg Asp Ile Val Leu Glu Leu Glu 
                165                 170                 175     


Glu Met Gly Phe Glu Ile Glu Ala Ser His His Glu Val Ala Pro Gly 
            180                 185                 190         


Gln His Glu Ile Asp Phe Lys Tyr Ala Gly Ala Val Arg Ser Cys Asp 
        195                 200                 205             


Asp Ile Gln Thr Phe Lys Leu Val Val Lys Thr Ile Ala Arg Lys His 
    210                 215                 220                 


Gly Leu His Ala Thr Phe Met Pro Lys Pro Leu Phe Gly Val Asn Gly 
225                 230                 235                 240 


Ser Gly Met His Cys Asn Leu Ser Leu Phe Lys Asn Gly Val Asn Ala 
                245                 250                 255     


Phe Phe Asp Glu Asn Ala Asp Leu Gln Leu Ser Glu Thr Ala Lys His 
            260                 265                 270         


Phe Ile Ala Gly Ile Val Lys His Ala Thr Ser Phe Thr Ala Val Thr 
        275                 280                 285             


Asn Pro Thr Val Asn Ser Tyr Lys Arg Leu Val Pro Gly Tyr Glu Ala 
    290                 295                 300                 


Pro Cys Tyr Val Ala Trp Ser Ala Gln Asn Arg Ser Pro Leu Ile Arg 
305                 310                 315                 320 


Ile Pro Ala Ser Arg Gly Ile Ser Thr Arg Val Glu Val Arg Ser Val 
                325                 330                 335     


Asp Pro Ala Ala Asn Pro Tyr Leu Ala Leu Ser Val Leu Leu Ala Ala 
            340                 345                 350         


Gly Leu Asp Gly Ile Lys Asn Lys Leu Glu Ala Pro Ala Pro Ile Asp 
        355                 360                 365             


Arg Asn Ile Tyr Val Met Ser Lys Glu Glu Arg Met Glu Asn Gly Ile 
    370                 375                 380                 


Val Asp Leu Pro Ala Thr Leu Ala Glu Ala Leu Glu Glu Phe Lys Ser 
385                 390                 395                 400 


Asn Glu Val Met Val Lys Ala Leu Gly Glu His Leu Phe Glu His Phe 
                405                 410                 415     


Ile Glu Ala Lys Glu Ile Glu Trp Asp Met Phe Arg Thr Gln Val His 
            420                 425                 430         


Pro Trp Glu Arg Glu Gln Tyr Met Ser Gln Tyr 
        435                 440             


<210>  40
<211>  454
<212>  PRT
<213>  Halobacterium volcanii

<400>  40

Met Thr Glu Asp Asn Ala Leu Thr Asp Gly Gly Leu Ser Asp Glu Ala 
1               5                   10                  15      


Gln Ala Val Ile Asp Glu Ile Glu Glu Lys Asn Val Asp Phe Leu Arg 
            20                  25                  30          


Leu Gln Phe Thr Asp Ile Leu Gly Thr Val Lys Asn Val Ser Ile Pro 
        35                  40                  45              


Ala Ser Gln Ala Glu Lys Ala Phe Thr Glu Gly Ile Tyr Phe Asp Gly 
    50                  55                  60                  


Ser Ser Ile Asp Gly Phe Val Arg Ile Gln Glu Ser Asp Met Arg Leu 
65                  70                  75                  80  


Glu Pro Asp Pro Ser Thr Phe Ala Val Leu Pro Trp Arg Lys Lys Glu 
                85                  90                  95      


Asn Ser Ala Ala Gly Arg Leu Ile Cys Asp Val Phe Asn Thr Ser Thr 
            100                 105                 110         


Gly Glu Pro Phe Ser Gly Asp Pro Arg Gly Val Leu Lys Arg Ala Ile 
        115                 120                 125             


Glu Pro Glu Glu Leu Gly Tyr Asp Val Asn Val Ala Pro Glu Pro Glu 
    130                 135                 140                 


Phe Phe Leu Phe Glu Glu Asp Glu Asp Gly Arg Ala Thr Thr Val Thr 
145                 150                 155                 160 


Asn Asp Ala Gly Gly Tyr Phe Asp Leu Ala Pro Lys Asp Leu Ala Ser 
                165                 170                 175     


Asp Val Arg Arg Asp Ile Ile Tyr Gly Leu Glu Ser Met Gly Phe Asp 
            180                 185                 190         


Ile Glu Ala Ser His His Glu Val Ala Glu Gly Gln His Glu Ile Asn 
        195                 200                 205             


Phe Thr Tyr Asp Asp Ala Leu Ser Thr Ala Asp Asn Val Arg Thr Phe 
    210                 215                 220                 


Arg Ser Val Val Arg Ala Ile Ala Ala Glu His Asp Leu His Ala Thr 
225                 230                 235                 240 


Phe Met Pro Lys Pro Ile Pro Arg Ile Asn Gly Ser Gly Met His Thr 
                245                 250                 255     


His Ile Ser Leu Phe Lys Asp Gly Glu Asn Ala Phe His Asp Gly Asp 
            260                 265                 270         


Asp Glu Phe Asp Leu Ser Asp Thr Ala Lys Ser Phe Val Ala Gly Ile 
        275                 280                 285             


Leu Asp His Ala Pro Ala Ile Thr Ala Ser Leu Thr Arg Arg Ser Thr 
    290                 295                 300                 


Pro Thr Arg Arg Leu Val Pro Gly Tyr Glu Ala Pro Val Tyr Ile Ala 
305                 310                 315                 320 


Trp Ser Asp Arg Asn Arg Ser Ala Leu Ile Arg Lys Pro Ala Ala Arg 
                325                 330                 335     


Thr Pro Ala Ala Ser Arg Ile Glu Ala Arg Phe Pro Asp Pro Ser Cys 
            340                 345                 350         


Asn Pro Tyr Leu Ala Phe Ala Ala Leu Ile His Ala Gly Leu Asp Gly 
        355                 360                 365             


Val Glu Lys Gly Leu Asp Cys Pro Asp Pro Val Arg Glu Asn Ile Tyr 
    370                 375                 380                 


Glu Phe Asp Glu Ala Lys Arg Glu Glu Tyr Gly Ile Glu Thr Leu Pro 
385                 390                 395                 400 


Lys Thr Ser Ala Ala Arg Arg Arg Pro Arg Arg Asp Glu Val Ile Gln 
                405                 410                 415     


Glu Ala Leu Gly Asp His Val Phe Glu Lys Phe Val Glu Ala Lys Arg 
            420                 425                 430         


Ser Glu Phe Lys Asp Tyr Leu Val Asp Val Ser Gln Trp Glu Leu Asp 
        435                 440                 445             


Arg Tyr Leu Glu Thr Phe 
    450                 


<210>  41
<211>  445
<212>  PRT
<213>  Lactobacillus delbrueckii

<400>  41

Met Ser Lys Val Ile Thr Glu Glu Glu Ile Arg Lys Asp Val Glu Glu 
1               5                   10                  15      


Lys Asn Val Arg Phe Leu Arg Leu Ala Phe Thr Asp Ile Asn Gly Thr 
            20                  25                  30          


Leu Lys Asn Leu Glu Val Pro Val Ser Gln Leu Asp Asp Val Leu Gly 
        35                  40                  45              


Asn Gln Thr Arg Phe Asp Gly Ser Ser Ile Asp Gly Phe Val Arg Leu 
    50                  55                  60                  


Glu Glu Ser Asp Met Val Leu Tyr Pro Asp Leu Ala Thr Trp Leu Val 
65                  70                  75                  80  


Leu Ala Trp Thr Thr Val Glu Glu Gly Thr Ile Gly Arg Leu Val Cys 
                85                  90                  95      


Ser Val His Asn Val Asp Gly Thr Pro Phe Glu Gly Asp Pro Arg Asn 
            100                 105                 110         


Asn Leu Lys Lys Val Ile Ala Glu Met Glu Glu Met Gly Phe Ser Asp 
        115                 120                 125             


Phe Glu Ile Gly Phe Glu Ala Glu Phe Phe Leu Phe Lys Glu Gly Lys 
    130                 135                 140                 


Asn Gly Glu Glu Thr Thr Lys Val Ser Asp His Ser Ser Tyr Phe Asp 
145                 150                 155                 160 


Met Ala Ser Glu Asp Glu Gly Ala Lys Cys Arg Arg Glu Ile Val Glu 
                165                 170                 175     


Thr Leu Glu Lys Leu Gly Phe Arg Val Glu Ala Ala His His Glu Val 
            180                 185                 190         


Gly Asp Gly Gln Gln Glu Ile Asp Phe Arg Phe Asp Asn Ala Leu Ala 
        195                 200                 205             


Thr Ala Asp Lys Leu Gln Thr Phe Lys Met Val Val Lys Thr Ile Ala 
    210                 215                 220                 


Arg Lys Tyr His Leu His Ala Ser Phe Met Ala Lys Pro Val Glu Gly 
225                 230                 235                 240 


Leu Ala Gly Asn Gly Met His Thr Asn Met Ser Leu Leu Lys Asp Gly 
                245                 250                 255     


Lys Asn Ala Phe Tyr Asp Lys Asp Gly Gln Tyr Asn Leu Ser Thr Thr 
            260                 265                 270         


Ala Leu Thr Phe Leu Asn Gly Ile Leu Glu His Ala Arg Ala Ile Thr 
        275                 280                 285             


Cys Val Ala Asn Pro Thr Val Asn Ser Tyr Lys Arg Leu Ile Pro Gly 
    290                 295                 300                 


Phe Glu Ala Pro Val Tyr Ile Ser Trp Ala Ser Arg Asn Arg Ser Pro 
305                 310                 315                 320 


Met Val Arg Ile Pro Asn Ala Asn Glu Val Gly Thr Arg Leu Glu Met 
                325                 330                 335     


Arg Ser Thr Asp Pro Thr Ala Asn Pro Tyr Leu Leu Leu Ser Ala Cys 
            340                 345                 350         


Leu Lys Ala Gly Leu Thr Gly Ile Lys Glu Gly Lys Leu Pro Met Ala 
        355                 360                 365             


Pro Val Thr Ser Asn Leu Phe Glu Met Thr Asp Asp Glu Arg Lys Glu 
    370                 375                 380                 


Leu Gly Ile Lys Pro Leu Pro Ser Thr Leu His Asn Ala Ile Lys Ala 
385                 390                 395                 400 


Phe Lys Glu Asp Glu Val Val Lys Ser Ala Phe Ser Glu His Ile Val 
                405                 410                 415     


Asp Ser Phe Leu Glu Leu Lys Glu Thr Glu Trp Ala Leu Tyr Thr Gln 
            420                 425                 430         


Ser Val Ser Glu Trp Glu Val Lys Arg Tyr Phe Asn Tyr 
        435                 440                 445 


<210>  42
<211>  428
<212>  PRT
<213>  Plasmodium falciparum

<400>  42

Met Cys Asp Ile Lys Arg Tyr Asn Gly Phe Asp Tyr Tyr Lys Cys Pro 
1               5                   10                  15      


Arg Thr Ile Leu Lys Lys Thr Cys Glu Phe Val Lys Asn Glu Gly Ile 
            20                  25                  30          


Ala Asp Lys Val Cys Ile Gly Asn Glu Leu Glu Phe Phe Ile Phe Asp 
        35                  40                  45              


Lys Val Asn Tyr Ser Leu Asp Glu Tyr Asn Thr Tyr Leu Lys Val Tyr 
    50                  55                  60                  


Asp Arg Glu Ser Phe Ser Cys Lys Asn Asp Leu Ser Ser Ile Tyr Gly 
65                  70                  75                  80  


Asn His Val Val Asn Lys Val Glu Pro His Lys Asp His Phe Asn Asn 
                85                  90                  95      


Pro Asn Asn Glu Tyr Leu Ile Asn Asp Asp Ser Lys Lys Val Lys Lys 
            100                 105                 110         


Lys Ser Gly Tyr Phe Thr Thr Asp Pro Tyr Asp Thr Ser Asn Ile Ile 
        115                 120                 125             


Lys Leu Arg Ile Cys Arg Ala Leu Asn Asp Met Asn Ile Asn Val Gln 
    130                 135                 140                 


Arg Tyr His His Glu Val Ser Thr Ser Gln His Glu Ile Ser Leu Lys 
145                 150                 155                 160 


Tyr Phe Asp Ala Leu Thr Asn Ala Asp Phe Leu Leu Ile Thr Lys Gln 
                165                 170                 175     


Ile Ile Lys Thr Thr Val Ser Ser Phe Asn Arg Thr Ala Thr Phe Met 
            180                 185                 190         


Pro Lys Pro Leu Val Asn Asp Asn Gly Asn Gly Leu His Cys Asn Ile 
        195                 200                 205             


Ser Leu Trp Lys Asn Asn Lys Asn Ile Phe Tyr His Asn Asp Pro Ser 
    210                 215                 220                 


Thr Phe Phe Leu Ser Lys Glu Ser Phe Tyr Phe Met Tyr Gly Ile Val 
225                 230                 235                 240 


Lys His Ala Lys Ala Leu Gln Ala Phe Cys Asn Ala Thr Met Asn Ser 
                245                 250                 255     


Tyr Lys Arg Leu Val Pro Gly Phe Glu Thr Cys Gln Lys Leu Phe Tyr 
            260                 265                 270         


Ser Phe Gly Ser Arg Ser Ala Val Ile Arg Leu Ser Leu Ile Asn Tyr 
        275                 280                 285             


Ser Asn Pro Ser Glu Lys Arg Ile Glu Phe Arg Leu Pro Asp Cys Ala 
    290                 295                 300                 


Asn Ser Pro His Leu Val Met Ala Ala Ile Ile Leu Ala Gly Tyr Asp 
305                 310                 315                 320 


Gly Ile Lys Ser Lys Glu Gln Pro Leu Val Pro Phe Glu Ser Lys Asp 
                325                 330                 335     


Asn His Phe Tyr Ile Ser Ser Ile Phe Ser Lys Tyr Val Gln His Pro 
            340                 345                 350         


Glu Asn Phe Asn Ile Leu Thr His Ala Leu Glu Gly Tyr Glu Ser Leu 
        355                 360                 365             


His Thr Ile Asn Glu Ser Pro Glu Phe Lys Asn Phe Phe Lys Cys Glu 
    370                 375                 380                 


Glu Pro Gln Gly Ile Ser Phe Ser Leu Val Glu Ser Leu Asp Ala Leu 
385                 390                 395                 400 


Glu Lys Asp His Ala Phe Leu Thr Val Asn Asn Ile Phe Thr Glu Val 
                405                 410                 415     


Ser Gln Arg Ile Lys Asn Lys His Tyr His Gly Lys 
            420                 425             


<210>  43
<211>  369
<212>  PRT
<213>  Saccharomyces cerevisiae

<400>  43

Ala Glu Ala Ser Ile Glu Lys Thr Gln Ile Leu Gln Lys Tyr Leu Glu 
1               5                   10                  15      


Leu Asp Gln Arg Gly Arg Ile Ile Ala Glu Tyr Val Trp Ile Asp Gly 
            20                  25                  30          


Thr Gly Asn Leu Arg Ser Lys Gly Arg Thr Leu Lys Lys Arg Ile Thr 
        35                  40                  45              


Ser Ile Asp Gln Leu Pro Glu Trp Asn Phe Asp Gly Ser Ser Thr Asn 
    50                  55                  60                  


Gln Ala Pro Gly His Asp Ser Asp Ile Tyr Leu Lys Pro Val Ala Tyr 
65                  70                  75                  80  


Tyr Pro Asp Pro Phe Arg Arg Gly Asp Asn Ile Val Val Leu Ala Ala 
                85                  90                  95      


Cys Tyr Asn Asn Asp Gly Thr Pro Asn Lys Phe Asn His Arg His Glu 
            100                 105                 110         


Ala Ala Lys Leu Phe Ala Ala His Lys Asp Glu Glu Ile Trp Phe Gly 
        115                 120                 125             


Leu Glu Gln Glu Tyr Thr Leu Phe Asp Met Tyr Asp Asp Val Tyr Gly 
    130                 135                 140                 


Trp Pro Lys Gly Gly Tyr Pro Ala Pro Gln Gly Pro Tyr Tyr Cys Gly 
145                 150                 155                 160 


Val Gly Ala Gly Lys Val Tyr Ala Arg Asp Met Ile Glu Ala His Tyr 
                165                 170                 175     


Arg Ala Cys Leu Tyr Ala Gly Leu Glu Ile Ser Gly Ile Asn Ala Glu 
            180                 185                 190         


Val Met Pro Ser Gln Trp Glu Phe Gln Val Gly Pro Cys Thr Gly Ile 
        195                 200                 205             


Asp Met Gly Asp Gln Leu Trp Met Ala Arg Tyr Phe Leu His Arg Val 
    210                 215                 220                 


Ala Glu Glu Phe Gly Ile Lys Ile Ser Phe His Pro Lys Pro Leu Lys 
225                 230                 235                 240 


Gly Asp Trp Asn Gly Ala Gly Cys His Thr Asn Val Ser Thr Lys Glu 
                245                 250                 255     


Met Arg Gln Pro Gly Gly Met Lys Tyr Ile Glu Gln Ala Ile Glu Lys 
            260                 265                 270         


Leu Ser Lys Arg His Ala Glu His Ile Lys Leu Tyr Gly Ser Asp Asn 
        275                 280                 285             


Asp Met Arg Leu Thr Gly Arg His Glu Thr Ala Ser Met Thr Ala Phe 
    290                 295                 300                 


Ser Ser Gly Val Ala Asn Arg Gly Ser Ser Ile Arg Ile Pro Arg Ser 
305                 310                 315                 320 


Val Ala Lys Glu Gly Tyr Gly Tyr Phe Glu Asp Arg Arg Pro Ala Ser 
                325                 330                 335     


Asn Ile Asp Pro Tyr Leu Val Thr Gly Ile Met Cys Glu Thr Val Cys 
            340                 345                 350         


Gly Ala Ile Asp Asn Ala Asp Met Thr Lys Glu Phe Glu Arg Glu Ser 
        355                 360                 365             


Ser 
    


<210>  44
<211>  382
<212>  PRT
<213>  Chlamydomonas reinhardtii

<400>  44

Met Ala Ala Gly Ser Val Gly Val Phe Ala Thr Asp Glu Lys Ile Gly 
1               5                   10                  15      


Ser Leu Leu Asp Gln Ser Ile Thr Arg His Phe Leu Ser Thr Val Thr 
            20                  25                  30          


Asp Gln Gln Gly Lys Ile Cys Ala Glu Tyr Val Trp Ile Gly Gly Ser 
        35                  40                  45              


Met His Asp Val Arg Ser Lys Ser Arg Thr Leu Ser Thr Ile Pro Thr 
    50                  55                  60                  


Lys Pro Glu Asp Leu Pro His Trp Asn Tyr Asp Gly Ser Ser Thr Gly 
65                  70                  75                  80  


Gln Ala Pro Gly His Asp Ser Glu Val Tyr Leu Ile Pro Arg Ser Ile 
                85                  90                  95      


Phe Lys Asp Pro Phe Arg Gly Gly Asp Asn Ile Leu Val Met Cys Asp 
            100                 105                 110         


Cys Tyr Glu Pro Pro Lys Val Asn Pro Asp Gly Thr Leu Ala Ala Pro 
        115                 120                 125             


Lys Pro Ile Pro Thr Asn Thr Arg Phe Ala Cys Ala Glu Val Met Glu 
    130                 135                 140                 


Lys Ala Lys Lys Glu Glu Pro Trp Phe Gly Ile Glu Gln Glu Tyr Thr 
145                 150                 155                 160 


Leu Leu Asn Ala Ile Thr Lys Trp Pro Leu Gly Trp Pro Lys Gly Gly 
                165                 170                 175     


Tyr Pro Ala Pro Gln Gly Pro Tyr Tyr Cys Ser Ala Gly Ala Gly Val 
            180                 185                 190         


Ala Ile Gly Arg Asp Val Ala Glu Val His Tyr Arg Leu Cys Leu Ala 
        195                 200                 205             


Ala Gly Val Asn Ile Ser Gly Val Asn Ala Glu Val Leu Pro Ser Gln 
    210                 215                 220                 


Trp Glu Tyr Gln Val Gly Pro Cys Glu Gly Ile Thr Met Gly Asp His 
225                 230                 235                 240 


Met Trp Met Ser Arg Tyr Ile Met Tyr Arg Val Cys Glu Met Phe Asn 
                245                 250                 255     


Val Glu Val Ser Phe Asp Pro Lys Pro Ile Pro Gly Asp Trp Asn Gly 
            260                 265                 270         


Ser Gly Gly His Thr Asn Tyr Ser Thr Lys Ala Thr Arg Thr Ala Pro 
        275                 280                 285             


Asp Gly Trp Lys Val Ile Gln Glu His Cys Ala Lys Leu Glu Ala Arg 
    290                 295                 300                 


His Ala Val His Ile Ala Ala Tyr Gly Glu Gly Asn Glu Arg Arg Leu 
305                 310                 315                 320 


Thr Gly Lys His Glu Thr Ser Ser Met Ser Asp Phe Ser Trp Gly Val 
                325                 330                 335     


Ala Asn Arg Gly Cys Ser Ile Arg Val Gly Arg Met Val Pro Val Glu 
            340                 345                 350         


Lys Ser Gly Tyr Tyr Glu Asp Arg Arg Pro Ala Ser Asn Leu Asp Ala 
        355                 360                 365             


Tyr Val Val Thr Arg Leu Ile Val Glu Thr Thr Ile Leu Leu 
    370                 375                 380         


<210>  45
<211>  357
<212>  PRT
<213>  Zea mays

<400>  45

Met Ala Ser Leu Thr Asp Leu Val Asn Leu Asp Leu Ser Asp Cys Thr 
1               5                   10                  15      


Asp Arg Ile Ile Ala Glu Tyr Ile Trp Ile Gly Gly Thr Gly Ile Asp 
            20                  25                  30          


Leu Arg Ser Lys Ala Arg Thr Val Lys Gly Pro Ile Thr Asp Pro Ile 
        35                  40                  45              


Gln Leu Pro Lys Trp Asn Tyr Asp Gly Ser Ser Thr Gly Gln Ala Pro 
    50                  55                  60                  


Gly Glu Asp Ser Glu Val Ile Leu Tyr Pro Gln Ala Ile Phe Lys Asp 
65                  70                  75                  80  


Pro Phe Arg Lys Gly Asn His Ile Leu Val Met Cys Asp Cys Tyr Thr 
                85                  90                  95      


Pro Gln Gly Glu Pro Ile Pro Thr Asn Lys Arg Tyr Ser Ala Ala Lys 
            100                 105                 110         


Val Phe Ser His Pro Asp Val Ala Ala Glu Val Pro Trp Tyr Gly Ile 
        115                 120                 125             


Glu Gln Glu Tyr Thr Leu Leu Gln Lys Asp Val Ser Trp Pro Leu Gly 
    130                 135                 140                 


Trp Pro Val Gly Gly Tyr Pro Gly Pro Gln Gly Pro Tyr Tyr Cys Ala 
145                 150                 155                 160 


Ala Gly Ala Asp Lys Ala Phe Gly Arg Asp Val Val Asp Ala His Tyr 
                165                 170                 175     


Lys Ala Cys Leu Tyr Ala Gly Ile Asn Ile Ser Gly Ile Asn Gly Glu 
            180                 185                 190         


Val Met Pro Gly Gln Trp Glu Phe Gln Val Gly Pro Ser Val Gly Ile 
        195                 200                 205             


Ser Ala Gly Asp Glu Ile Trp Val Ala Arg Tyr Ile Leu Glu Arg Ile 
    210                 215                 220                 


Thr Glu Met Ala Gly Ile Val Leu Ser Leu Asp Pro Lys Pro Ile Lys 
225                 230                 235                 240 


Gly Asp Trp Asn Gly Ala Gly Ala His Thr Asn Tyr Ser Thr Lys Ser 
                245                 250                 255     


Met Arg Glu Ala Gly Gly Tyr Glu Val Ile Lys Ala Ala Ile Asp Lys 
            260                 265                 270         


Leu Gly Lys Arg His Lys Glu His Ile Ala Ala Tyr Gly Glu Gly Asn 
        275                 280                 285             


Glu Arg Arg Leu Thr Gly Arg His Glu Thr Ala Asp Ile Asn Thr Phe 
    290                 295                 300                 


Lys Trp Gly Val Ala Asn Arg Gly Ala Ser Ile Arg Val Gly Arg Asp 
305                 310                 315                 320 


Thr Glu Arg Glu Gly Lys Gly Tyr Phe Glu Asp Arg Arg Pro Ala Ser 
                325                 330                 335     


Asn Met Asp Pro Tyr Val Val Thr Gly Met Ile Ala Glu Thr Thr Ile 
            340                 345                 350         


Leu Trp Asn Gly Asn 
        355         


<210>  46
<211>  357
<212>  PRT
<213>  Orysa sativa

<400>  46

Met Ala Asn Leu Thr Asp Leu Val Asn Leu Asn Leu Ser Asp Cys Ser 
1               5                   10                  15      


Asp Lys Ile Ile Ala Glu Tyr Ile Trp Val Gly Gly Ser Gly Ile Asp 
            20                  25                  30          


Leu Arg Ser Lys Ala Arg Thr Val Lys Gly Pro Ile Thr Asp Val Ser 
        35                  40                  45              


Gln Leu Pro Lys Trp Asn Tyr Asp Gly Ser Ser Thr Gly Gln Ala Pro 
    50                  55                  60                  


Gly Glu Asp Ser Glu Val Ile Leu Tyr Pro Gln Ala Ile Phe Lys Asp 
65                  70                  75                  80  


Pro Phe Arg Arg Gly Asp Asn Ile Leu Val Met Cys Asp Cys Tyr Thr 
                85                  90                  95      


Pro Gln Gly Glu Pro Ile Pro Thr Asn Lys Arg His Ser Ala Ala Lys 
            100                 105                 110         


Ile Phe Ser His Pro Asp Val Val Ala Glu Val Pro Trp Tyr Gly Ile 
        115                 120                 125             


Glu Gln Glu Tyr Thr Leu Leu Gln Lys Asp Val Asn Trp Pro Leu Gly 
    130                 135                 140                 


Trp Pro Val Gly Gly Phe Pro Gly Pro Gln Gly Pro Tyr Tyr Cys Ala 
145                 150                 155                 160 


Ala Gly Ala Glu Lys Ala Phe Gly Arg Asp Ile Val Asp Ala His Tyr 
                165                 170                 175     


Lys Ala Cys Ile Tyr Ala Gly Ile Asn Ile Ser Gly Ile Asn Gly Glu 
            180                 185                 190         


Val Met Pro Gly Gln Trp Glu Phe Gln Val Gly Pro Ser Val Gly Ile 
        195                 200                 205             


Ala Ala Ala Asp Gln Val Trp Val Ala Arg Tyr Ile Leu Glu Arg Val 
    210                 215                 220                 


Thr Glu Val Ala Gly Val Val Leu Ser Leu Asp Pro Lys Pro Ile Pro 
225                 230                 235                 240 


Gly Asp Trp Asn Gly Ala Gly Ala His Thr Asn Phe Ser Thr Lys Ser 
                245                 250                 255     


Met Arg Glu Pro Gly Gly Tyr Glu Val Ile Lys Lys Ala Ile Asp Lys 
            260                 265                 270         


Leu Ala Leu Arg His Lys Glu His Ile Ala Ala Tyr Gly Glu Gly Asn 
        275                 280                 285             


Glu Arg Arg Leu Thr Gly Arg His Glu Thr Ala Asp Ile Asn Thr Phe 
    290                 295                 300                 


Lys Trp Gly Val Ala Asn Arg Gly Ala Ser Ile Arg Val Gly Arg Asp 
305                 310                 315                 320 


Thr Glu Lys Glu Gly Lys Gly Tyr Phe Glu Asp Arg Arg Pro Ala Ser 
                325                 330                 335     


Asn Met Asp Pro Tyr Val Val Thr Gly Met Ile Ala Glu Thr Thr Leu 
            340                 345                 350         


Leu Trp Lys Gln Asn 
        355         


<210>  47
<211>  353
<212>  PRT
<213>  Lupinus luteus

<400>  47

Met Ser Val Leu Ser Asp Leu Ile Asn Leu Asn Leu Ser Asp Thr Thr 
1               5                   10                  15      


Glu Lys Ile Ile Ala Glu Tyr Ile Trp Val Gly Gly Ser Gly Val Asp 
            20                  25                  30          


Leu Arg Ser Lys Ala Arg Thr Leu Ser Gly Pro Val Asn Asp Pro Ser 
        35                  40                  45              


Lys Leu Pro Lys Trp Asn Tyr Asp Gly Ser Ser Thr Gly Gln Ala Pro 
    50                  55                  60                  


Gly Lys Asp Ser Glu Val Ile Leu Trp Pro Gln Ala Ile Phe Lys Asp 
65                  70                  75                  80  


Pro Phe Arg Arg Gly Asn Asn Ile Leu Val Met Cys Asp Thr Tyr Thr 
                85                  90                  95      


Pro Ala Gly Glu Pro Ile Pro Thr Asn Lys Arg His Ala Ala Ala Lys 
            100                 105                 110         


Ile Phe Ser His Pro Asp Val Val Ala Glu Glu Pro Trp Phe Gly Ile 
        115                 120                 125             


Glu Gln Glu Tyr Thr Leu Leu Gln Lys Asp Ile His Trp Pro Ile Gly 
    130                 135                 140                 


Trp Pro Leu Gly Gly Phe Pro Gly Pro Gln Gly Pro Tyr Tyr Cys Gly 
145                 150                 155                 160 


Thr Gly Ala Glu Lys Ala Phe Gly Arg Asp Ile Val Asp Ser His Tyr 
                165                 170                 175     


Lys Ala Cys Leu Tyr Ala Gly Ile Asn Ile Ser Gly Ile Asn Ala Glu 
            180                 185                 190         


Val Met Pro Gly Gln Trp Glu Phe Gln Val Gly Pro Ser Val Gly Ile 
        195                 200                 205             


Ser Ala Gly Asp Glu Leu Trp Val Ala Arg Tyr Ile Leu Glu Arg Ile 
    210                 215                 220                 


Thr Glu Ile Ala Gly Val Val Leu Ser Leu Asp Pro Lys Pro Ile Pro 
225                 230                 235                 240 


Gly Asp Trp Asn Gly Ala Gly Ala His Thr Asn Tyr Ser Thr Lys Ser 
                245                 250                 255     


Met Arg Asn Asp Gly Gly Tyr Glu Val Ile Lys Lys Ala Ile Glu Lys 
            260                 265                 270         


Leu Gly Lys Arg His Asn Glu His Ile Ala Ala Tyr Gly Glu Gly Asn 
        275                 280                 285             


Glu Arg Arg Leu Thr Gly Arg His Glu Thr Ala Asp Ile Ser Thr Phe 
    290                 295                 300                 


Phe Trp Gly Val Ala Asn Arg Gly Ala Ser Ile Arg Val Gly Arg Asp 
305                 310                 315                 320 


Thr Glu Lys Glu Gly Lys Gly Tyr Phe Glu Asp Arg Arg Pro Ala Ser 
                325                 330                 335     


Asn Met Asp Pro Tyr Val Val Thr Ser Met Ile Ala Glu Thr Thr Leu 
            340                 345                 350         


Leu 
    


<210>  48
<211>  357
<212>  PRT
<213>  Pisum sativum

<400>  48

Met Ser Ser Leu Ser Asp Leu Ile Asn Phe Asn Leu Ser Asp Ser Thr 
1               5                   10                  15      


Glu Lys Ile Ile Ala Glu Tyr Ile Trp Val Gly Gly Ser Gly Ile Asp 
            20                  25                  30          


Ile Arg Ser Lys Ala Arg Thr Leu Pro Gly Pro Val Ser Asp Pro Ala 
        35                  40                  45              


Lys Leu Pro Lys Trp Asn Tyr Asp Gly Ser Ser Thr Asn Gln Ala Pro 
    50                  55                  60                  


Gly Lys Asp Ser Glu Val Ile Leu Tyr Pro Gln Ala Ile Phe Lys Asp 
65                  70                  75                  80  


Pro Phe Arg Arg Gly Asn Asn Ile Leu Val Ile Cys Asp Val Tyr Thr 
                85                  90                  95      


Pro Ala Gly Glu Pro Leu Pro Thr Asn Lys Arg Tyr Asn Ala Ala Lys 
            100                 105                 110         


Ile Phe Ser His Pro Asp Val Ala Ala Glu Val Pro Trp Tyr Gly Ile 
        115                 120                 125             


Glu Gln Glu Tyr Thr Leu Leu Gln Lys Asp Ile Asn Trp Pro Leu Gly 
    130                 135                 140                 


Trp Pro Ile Gly Gly Tyr Pro Gly Lys Gln Gly Pro Tyr Tyr Cys Gly 
145                 150                 155                 160 


Ile Gly Ala Asp Lys Ala Tyr Gly Arg Asp Ile Val Asp Ala His Tyr 
                165                 170                 175     


Lys Ala Cys Leu Phe Ala Gly Ile Asn Ile Ser Gly Ile Asn Gly Glu 
            180                 185                 190         


Val Met Pro Gly Gln Trp Glu Phe Gln Val Gly Pro Ser Val Gly Ile 
        195                 200                 205             


Ser Ala Gly Asp Glu Ile Trp Ala Ala Arg Tyr Ile Leu Glu Arg Ile 
    210                 215                 220                 


Thr Glu Ile Ala Gly Val Val Val Ser Phe Asp Pro Lys Pro Ile Pro 
225                 230                 235                 240 


Gly Asp Trp Asn Gly Ala Gly Ala His Ala Asn Phe Ser Thr Lys Ser 
                245                 250                 255     


Met Arg Glu Asn Gly Gly Tyr Glu Val Ile Lys Lys Ala Ile Glu Lys 
            260                 265                 270         


Leu Gly Leu Arg His Lys Glu His Ile Ala Ala Tyr Gly Glu Gly Asn 
        275                 280                 285             


Glu Arg Arg Leu Thr Gly Lys His Glu Thr Ala Asp Ile Asn Val Phe 
    290                 295                 300                 


Ser Trp Gly Val Ala Asn Arg Gly Ser Ser Ile Arg Val Gly Arg Asp 
305                 310                 315                 320 


Thr Glu Lys Asp Gly Lys Gly Tyr Phe Glu Asp Arg Arg Pro Ala Ser 
                325                 330                 335     


Asn Met Asp Pro Tyr Val Val Thr Ser Met Ile Ala Glu Thr Thr Ile 
            340                 345                 350         


Leu Trp Lys Lys Pro 
        355         


<210>  49
<211>  399
<212>  PRT
<213>  Drosophila melanogaster

<400>  49

Met Ala Leu Arg Val Ala Gly Leu Phe Leu Lys Lys Glu Leu Val Ala 
1               5                   10                  15      


Pro Ala Thr Gln Gln Leu Arg Leu Leu Arg Thr Gly Asn Thr Thr Arg 
            20                  25                  30          


Ser Gln Phe Leu Ala Asn Ser Pro Asn Thr Ala Leu Asp Lys Ser Ile 
        35                  40                  45              


Leu Gln Arg Tyr Arg Asn Leu Glu Thr Pro Ala Asn Arg Val Gln Ala 
    50                  55                  60                  


Thr Tyr Leu Trp Ile Asp Gly Thr Gly Glu Asn Ile Arg Leu Lys Asp 
65                  70                  75                  80  


Arg Val Leu Asp Lys Val Pro Ser Ser Val Glu Asp Leu Pro Asp Trp 
                85                  90                  95      


Gln Tyr Asp Gly Ser Ser Thr Tyr Gln Ala His Gly Glu Asn Ser Asp 
            100                 105                 110         


Thr Thr Leu Lys Pro Arg Ala Ile Tyr Arg Asp Pro Phe Lys Pro Gly 
        115                 120                 125             


Lys Asn Asp Val Ile Val Leu Cys Asp Thr Tyr Ser Ala Asp Gly Lys 
    130                 135                 140                 


Pro Thr Ala Ser Asn Lys Arg Ala Ala Phe Gln Ala Ala Ile Asp Leu 
145                 150                 155                 160 


Ile Ser Asp Gln Glu Pro Trp Phe Gly Ile Glu Gln Glu Tyr Thr Leu 
                165                 170                 175     


Leu Arg Arg Gly Arg Thr Ser Phe Gly Trp Pro Glu Asn Gly Phe Pro 
            180                 185                 190         


Ala Pro Gln Gly Pro Tyr Tyr Cys Gly Val Gly Ala Asp Arg Val Tyr 
        195                 200                 205             


Ala Arg Asp Leu Val Glu Ala His Val Val Ala Cys Leu Tyr Ala Gly 
    210                 215                 220                 


Ile Asp Phe Ala Gly Thr Asn Ala Glu Val Met Pro Ala Gln Trp Glu 
225                 230                 235                 240 


Phe Gln Ile Gly Pro Ala Gly Ile Lys Ala Cys Asp Asp Leu Trp Val 
                245                 250                 255     


Ser Arg Tyr Ile Leu Gln Arg Ile Ala Glu Glu Tyr Gly Val Val Val 
            260                 265                 270         


Thr Phe Asp Pro Lys Pro Met Glu Gly Gln Trp Asn Gly Ala Gly Arg 
        275                 280                 285             


His Thr Asn Phe Ser Thr Lys Glu Met Arg Ala Asp Gly Gly Ile Lys 
    290                 295                 300                 


Ala Ile Glu Glu Pro Ile Glu Lys Leu Ser Lys Arg His Glu Arg His 
305                 310                 315                 320 


Ile Lys Ala Tyr Tyr Pro Lys Glu Gly Lys Asp Asn Glu Arg Arg Leu 
                325                 330                 335     


Val Gly Arg Leu Glu Thr Ser Ser Ile Asp Lys Phe Ser Trp Gly Val 
            340                 345                 350         


Ala Asn Arg Ala Val Ser Val Arg Val Pro Arg Gly Val Ala Thr Ala 
        355                 360                 365             


Gly Lys Gly Tyr Leu Glu Asp Arg Arg Pro Ser Ser Asn Cys Asp Pro 
    370                 375                 380                 


Tyr Ala Val Cys Asn Ala Ile Val Gln Thr Cys Leu Leu Asn Glu 
385                 390                 395                 


<210>  50
<211>  403
<212>  PRT
<213>  Squalus acanthia

<400>  50

Met Arg Ile Cys Arg Ser Phe Leu Phe Leu Val Lys Lys Cys Gly Asn 
1               5                   10                  15      


Ile Thr Pro Thr Ile Trp Arg Asn Gln His Thr Tyr Lys Met Ala Thr 
            20                  25                  30          


Ser Ala Ser Ala Asn Leu Ser Lys Ile Val Lys Lys Asn Tyr Met Glu 
        35                  40                  45              


Leu Pro Gln Asp Gly Lys Val Gln Ala Met Tyr Ile Trp Ile Asp Gly 
    50                  55                  60                  


Thr Gly Glu Ala Val Arg Cys Lys Thr Arg Thr Leu Asp Asn Glu Pro 
65                  70                  75                  80  


Lys Ser Ile Ala Glu Leu Pro Glu Trp Asn Phe Asp Gly Ser Ser Thr 
                85                  90                  95      


Tyr Gln Ser Glu Gly Ser Asn Ser Asp Met Tyr Leu Val Pro Ser Ala 
            100                 105                 110         


Met Phe Arg Asp Pro Phe Arg Arg Asp Pro Asn Lys Leu Val Leu Cys 
        115                 120                 125             


Glu Val Leu Lys Tyr Asn Arg Lys Pro Ala Glu Ser Asn Leu Arg His 
    130                 135                 140                 


Ser Cys Gln Lys Ile Met Ser Met Ile Ala Asn Glu Tyr Pro Trp Phe 
145                 150                 155                 160 


Gly Met Glu Gln Glu Tyr Thr Leu Leu Gly Thr Asp Gly His Pro Phe 
                165                 170                 175     


Gly Trp Pro Ser Asn Cys Phe Pro Gly Pro Gln Gly Pro Tyr Tyr Cys 
            180                 185                 190         


Gly Val Gly Ala Asp Lys Ala Tyr Gly Arg Asp Ile Val Glu Ala His 
        195                 200                 205             


Tyr Arg Ala Cys Leu Tyr Ala Gly Ile Glu Leu Ser Gly Thr Asn Ala 
    210                 215                 220                 


Glu Val Met Ala Ala Gln Trp Glu Tyr Gln Val Gly Pro Cys Glu Gly 
225                 230                 235                 240 


Ile Gln Met Gly Asp His Leu Trp Ile Ser Arg Phe Ile Leu His Arg 
                245                 250                 255     


Val Cys Glu Asp Phe Gly Ile Ile Ala Ser Phe Asp Pro Lys Pro Ile 
            260                 265                 270         


Pro Gly Asn Trp Asn Gly Ala Gly Cys His Thr Asn Phe Ser Thr Lys 
        275                 280                 285             


Ala Met Arg Asp Asp Gly Gly Leu Lys Tyr Ile Glu Asp Ser Ile Glu 
    290                 295                 300                 


Lys Leu Gly Lys Arg His Gln Tyr His Ile Arg Ala Tyr Asp Pro Lys 
305                 310                 315                 320 


Gly Gly Leu Asp Asn Ala Arg Ala Leu Thr Gly His His Glu Thr Ser 
                325                 330                 335     


Asn Ile Asn Glu Phe Ser Ala Gly Val Ala Asn Arg Gly Ala Ser Ile 
            340                 345                 350         


Arg Ile Pro Arg Ser Val Gly Gln Asp Lys Lys Gly Tyr Phe Glu Asp 
        355                 360                 365             


Arg Arg Pro Ser Ala Asn Cys Asp Pro Tyr Ala Val Thr Glu Ala Leu 
    370                 375                 380                 


Val Arg Thr Cys Leu Leu Asp Glu Ser Gly Asp Lys Pro Ile Glu Tyr 
385                 390                 395                 400 


Asn Lys Asn 
            


<210>  51
<211>  392
<212>  PRT
<213>  Xenopus laevis

<400>  51

Met Ser Val Ser His Ser Ser Arg Leu Asn Lys Gly Val Arg Glu Gln 
1               5                   10                  15      


Tyr Met Lys Leu Pro Gln Gly Glu Lys Val Gln Val Thr Tyr Val Trp 
            20                  25                  30          


Ile Asp Gly Thr Gly Glu Gly Val Arg Cys Lys Thr Arg Thr Leu Asp 
        35                  40                  45              


Gln Glu Pro Lys Thr Ile Asp Glu Ile Pro Glu Trp Asn Phe Asp Gly 
    50                  55                  60                  


Ser Ser Thr His Gln Ala Glu Gly Ser Asn Ser Asp Met Tyr Leu Ile 
65                  70                  75                  80  


Pro Val Gln Met Phe Arg Asp Pro Phe Cys Leu Asp Pro Asn Lys Leu 
                85                  90                  95      


Val Met Cys Glu Val Leu Lys Tyr Asn Arg Lys Ser Ala Glu Thr Asn 
            100                 105                 110         


Leu Arg His Thr Cys Lys Lys Ile Met Glu Met Val Asn Asp His Arg 
        115                 120                 125             


Pro Trp Phe Gly Met Glu Gln Glu Tyr Thr Leu Leu Gly Ile Asn Gly 
    130                 135                 140                 


His Pro Tyr Gly Trp Pro Glu Asn Gly Phe Pro Gly Pro Gln Gly Pro 
145                 150                 155                 160 


Tyr Tyr Cys Gly Val Gly Ala Asp Lys Val Tyr Gly Arg Asp Val Val 
                165                 170                 175     


Glu Ser His Tyr Lys Ala Cys Leu Tyr Ala Gly Ile Lys Ile Cys Gly 
            180                 185                 190         


Thr Asn Ala Glu Val Met Pro Ser Gln Trp Glu Phe Gln Val Gly Pro 
        195                 200                 205             


Cys Glu Gly Ile Asp Met Gly Asp His Leu Trp Met Ala Arg Phe Ile 
    210                 215                 220                 


Leu His Arg Val Cys Glu Asp Phe Gly Val Val Ala Thr Leu Asp Pro 
225                 230                 235                 240 


Lys Pro Met Thr Gly Asn Trp Asn Gly Ala Gly Cys His Thr Asn Tyr 
                245                 250                 255     


Ser Thr Glu Ser Met Arg Val Glu Gly Gly Leu Lys His Ile Glu Asp 
            260                 265                 270         


Ala Ile Glu Lys Leu Gly Lys Arg His Asp Tyr His Ile Cys Val Tyr 
        275                 280                 285             


Asp Pro Arg Gly Gly Lys Asp Asn Ser Arg Arg Leu Thr Gly Gln His 
    290                 295                 300                 


Glu Thr Ser Ser Ile His Glu Phe Ser Ala Gly Val Ala Asn Arg Gly 
305                 310                 315                 320 


Ala Ser Ile Arg Ile Pro Arg Gln Val Gly Gln Glu Gly Tyr Gly Tyr 
                325                 330                 335     


Phe Glu Asp Arg Arg Pro Ala Ala Asn Cys Asp Pro Tyr Ala Val Thr 
            340                 345                 350         


Glu Ala Leu Val Arg Thr Thr Ile Leu Asn Glu Thr Gly Ser Glu Thr 
        355                 360                 365             


Lys Asp Tyr Lys Asn Gly Ala Gly Phe Ser Arg Ala Ile Gly Met Ala 
    370                 375                 380                 


Ser Pro Arg Asp Ala Ala Val Phe 
385                 390         


<210>  52
<211>  373
<212>  PRT
<213>  Gallus gallus

<400>  52

Met Ala Thr Ser Ala Ser Ser His Leu Ser Lys Ala Ile Lys His Met 
1               5                   10                  15      


Tyr Met Lys Leu Pro Gln Gly Glu Lys Val Gln Ala Met Tyr Ile Trp 
            20                  25                  30          


Ile Asp Gly Thr Gly Glu His Leu Arg Cys Lys Thr Arg Thr Leu Asp 
        35                  40                  45              


His Glu Pro Lys Ser Leu Glu Asp Leu Pro Glu Trp Asn Phe Asp Gly 
    50                  55                  60                  


Ser Ser Thr Phe Gln Ala Glu Gly Ser Asn Ser Asp Met Tyr Leu Arg 
65                  70                  75                  80  


Pro Ala Ala Met Phe Arg Asp Pro Phe Arg Lys Asp Pro Asn Lys Leu 
                85                  90                  95      


Val Leu Cys Glu Val Phe Lys Tyr Asn Arg Gln Ser Ala Asp Thr Asn 
            100                 105                 110         


Leu Arg His Thr Cys Arg Arg Ile Met Asp Met Val Ser Asn Gln His 
        115                 120                 125             


Pro Trp Phe Gly Met Glu Gln Glu Tyr Thr Leu Leu Gly Thr Asp Gly 
    130                 135                 140                 


His Pro Phe Gly Trp Pro Ser Asn Cys Phe Pro Gly Pro Gln Gly Pro 
145                 150                 155                 160 


Tyr Tyr Cys Gly Val Gly Ala Asp Lys Ala Tyr Gly Arg Asp Ile Val 
                165                 170                 175     


Glu Ala His Tyr Arg Ala Cys Leu Tyr Ala Gly Val Lys Ile Gly Gly 
            180                 185                 190         


Thr Asn Ala Glu Val Met Pro Ala Gln Trp Glu Phe Gln Val Gly Pro 
        195                 200                 205             


Cys Glu Gly Ile Glu Met Gly Asp His Leu Trp Ile Ala Arg Phe Ile 
    210                 215                 220                 


Leu His Arg Val Cys Glu Asp Phe Gly Val Ile Val Ser Phe Asp Pro 
225                 230                 235                 240 


Lys Pro Ile Pro Gly Asn Trp Asn Gly Ala Gly Cys His Thr Asn Phe 
                245                 250                 255     


Ser Thr Lys Asn Met Arg Glu Asp Gly Gly Leu Lys His Ile Glu Glu 
            260                 265                 270         


Ala Ile Glu Lys Leu Ser Lys Arg His Gln Tyr His Ile Arg Ala Tyr 
        275                 280                 285             


Asp Pro Lys Gly Gly Leu Asp Asn Ala Arg Arg Leu Thr Gly Phe His 
    290                 295                 300                 


Glu Thr Ser Ser Ile His Glu Phe Ser Ala Gly Val Ala Asn Arg Gly 
305                 310                 315                 320 


Ala Ser Ile Arg Ile Pro Arg Asn Val Gly His Glu Lys Lys Gly Tyr 
                325                 330                 335     


Phe Glu Asp Arg Gly Pro Ser Ala Asn Cys Asp Pro Tyr Ala Val Thr 
            340                 345                 350         


Glu Ala Leu Val Arg Thr Cys Leu Leu Asn Glu Thr Gly Asp Glu Pro 
        355                 360                 365             


Phe Glu Tyr Lys Asn 
    370             


<210>  53
<211>  373
<212>  PRT
<213>  Mus musculus

<400>  53

Met Ala Thr Ser Ala Ser Ser His Leu Asn Lys Gly Ile Lys Gln Met 
1               5                   10                  15      


Tyr Met Ser Leu Pro Gln Gly Glu Lys Val Gln Ala Met Tyr Ile Trp 
            20                  25                  30          


Val Asp Gly Thr Gly Glu Gly Leu Arg Cys Lys Thr Arg Thr Leu Asp 
        35                  40                  45              


Cys Glu Pro Lys Cys Val Glu Glu Leu Pro Glu Trp Asn Phe Asp Gly 
    50                  55                  60                  


Ser Ser Thr Phe Gln Ser Glu Gly Ser Asn Ser Asp Met Tyr Leu His 
65                  70                  75                  80  


Pro Val Ala Met Phe Arg Asp Pro Phe Arg Arg Asp Pro Asn Lys Leu 
                85                  90                  95      


Val Leu Cys Glu Val Phe Lys Tyr Asn Arg Lys Pro Ala Glu Thr Asn 
            100                 105                 110         


Leu Arg His Ile Cys Lys Arg Ile Met Asp Met Val Ser Asn Gln His 
        115                 120                 125             


Pro Trp Phe Gly Met Glu Gln Glu Tyr Thr Leu Met Gly Thr Asp Gly 
    130                 135                 140                 


His Pro Phe Gly Trp Pro Ser Asn Gly Phe Pro Gly Pro Gln Gly Pro 
145                 150                 155                 160 


Tyr Tyr Cys Gly Val Gly Ala Asp Lys Ala Tyr Gly Arg Asp Ile Val 
                165                 170                 175     


Glu Ala His Tyr Arg Ala Cys Leu Tyr Ala Gly Val Lys Ile Thr Gly 
            180                 185                 190         


Thr Asn Ala Glu Val Met Pro Ala Gln Trp Glu Phe Gln Ile Gly Pro 
        195                 200                 205             


Cys Glu Gly Ile Arg Met Gly Asp His Leu Trp Ile Ala Arg Phe Ile 
    210                 215                 220                 


Leu His Arg Val Cys Glu Asp Phe Gly Val Ile Ala Thr Phe Asp Pro 
225                 230                 235                 240 


Lys Pro Ile Pro Gly Asn Trp Asn Val Ala Gly Cys His Thr Asn Phe 
                245                 250                 255     


Ser Thr Lys Ala Met Arg Glu Glu Asn Gly Leu Lys Cys Ile Glu Glu 
            260                 265                 270         


Ala Ile Asp Lys Leu Ser Lys Arg His Gln Tyr His Ile Arg Ala Tyr 
        275                 280                 285             


Asp Pro Lys Gly Gly Leu Asp Asn Ala Arg Ala Leu Thr Gly Phe His 
    290                 295                 300                 


Glu Thr Ser Asn Ile Asn Asp Phe Ser Ala Gly Val Ala Asn Arg Gly 
305                 310                 315                 320 


Ala Ser Ile Arg Ile Pro Arg Thr Val Gly Gln Glu Lys Lys Gly Tyr 
                325                 330                 335     


Phe Glu Asp Arg Arg Leu Arg Ala Asn Cys Asp Pro Tyr Ala Val Thr 
            340                 345                 350         


Glu Ala Ile Val Arg Thr Cys Leu Leu Asn Glu Thr Gly Asp Glu Pro 
        355                 360                 365             


Phe Gln Tyr Lys Asn 
    370             


<210>  54
<211>  373
<212>  PRT
<213>  Cricetulus griseus

<400>  54

Met Ala Thr Ser Ala Ser Ser His Leu Asn Lys Gly Ile Lys Gln Met 
1               5                   10                  15      


Tyr Met Ser Leu Pro Gln Gly Glu Lys Val Gln Ala Met Tyr Ile Trp 
            20                  25                  30          


Val Asp Gly Thr Gly Glu Gly Leu Arg Cys Lys Thr Arg Thr Leu Asp 
        35                  40                  45              


Cys Glu Pro Lys Cys Val Glu Glu Leu Pro Glu Trp Asn Phe Asp Gly 
    50                  55                  60                  


Ser Ser Thr Phe Gln Ser Glu Ser Ser Asn Ser Asp Met Tyr Leu Ser 
65                  70                  75                  80  


Pro Val Ala Met Phe Arg Asp Pro Phe Arg Lys Glu Pro Asn Lys Leu 
                85                  90                  95      


Val Phe Cys Glu Val Phe Lys Tyr Asn Gln Lys Pro Ala Glu Thr Asn 
            100                 105                 110         


Leu Arg His Thr Cys Lys Arg Ile Met Asp Met Val Ser Asn Gln His 
        115                 120                 125             


Pro Trp Phe Gly Met Glu Gln Glu Tyr Thr Leu Leu Gly Thr Asp Gly 
    130                 135                 140                 


His Pro Phe Gly Trp Pro Ser Asp Gly Phe Pro Gly Pro Gln Gly Leu 
145                 150                 155                 160 


Tyr Tyr Cys Gly Val Gly Ala Asp Lys Ala Tyr Arg Arg Asp Ile Met 
                165                 170                 175     


Glu Ala His Tyr Arg Ala Cys Leu Tyr Ala Gly Val Lys Ile Thr Gly 
            180                 185                 190         


Thr Tyr Ala Glu Val Lys His Ala Gln Trp Glu Phe Gln Ile Gly Pro 
        195                 200                 205             


Cys Glu Gly Ile Arg Met Gly Asp His Leu Trp Val Ala Arg Phe Ile 
    210                 215                 220                 


Leu His Arg Val Cys Lys Asp Phe Gly Val Ile Ala Thr Phe Asp Ser 
225                 230                 235                 240 


Lys Pro Ile Pro Gly Asn Trp Asn Gly Ala Gly Cys His Thr Asn Phe 
                245                 250                 255     


Ser Thr Lys Thr Met Arg Glu Glu Asn Gly Leu Lys His Ile Lys Glu 
            260                 265                 270         


Ala Ile Glu Lys Leu Ser Lys Arg His Arg Tyr His Ile Arg Ala Tyr 
        275                 280                 285             


Asp Pro Lys Gly Gly Leu Asp Asn Ala Arg Arg Leu Thr Gly Phe His 
    290                 295                 300                 


Lys Thr Ser Asn Ile Asn Asp Phe Ser Ala Gly Val Ala Asp Arg Ser 
305                 310                 315                 320 


Ala Ser Ile Arg Ile Pro Arg Thr Val Gly Gln Glu Lys Lys Gly Tyr 
                325                 330                 335     


Phe Glu Ala Arg Cys Pro Ser Ala Asn Cys Asp Pro Phe Ala Val Thr 
            340                 345                 350         


Glu Ala Ile Val Arg Thr Cys Leu Leu Asn Glu Thr Gly Asp Gln Pro 
        355                 360                 365             


Phe Gln Tyr Lys Asn 
    370             


<210>  55
<211>  373
<212>  PRT
<213>  Homo sapiens

<400>  55

Met Thr Thr Ser Ala Ser Ser His Leu Asn Lys Gly Ile Lys Gln Val 
1               5                   10                  15      


Tyr Met Ser Leu Pro Gln Gly Glu Lys Val Gln Ala Met Tyr Ile Trp 
            20                  25                  30          


Ile Asp Gly Thr Gly Glu Gly Leu Arg Cys Lys Thr Arg Thr Leu Asp 
        35                  40                  45              


Ser Glu Pro Lys Cys Val Glu Glu Leu Pro Glu Trp Asn Phe Asp Gly 
    50                  55                  60                  


Ser Ser Thr Leu Gln Ser Glu Gly Ser Asn Ser Asp Met Tyr Leu Val 
65                  70                  75                  80  


Pro Ala Ala Met Phe Arg Asp Pro Phe Arg Lys Asp Pro Asn Lys Leu 
                85                  90                  95      


Val Leu Cys Glu Val Phe Lys Tyr Asn Arg Arg Pro Ala Glu Thr Asn 
            100                 105                 110         


Leu Arg His Thr Cys Lys Arg Ile Met Asp Met Val Ser Asn Gln His 
        115                 120                 125             


Pro Trp Phe Gly Met Glu Gln Glu Tyr Thr Leu Met Gly Thr Asp Gly 
    130                 135                 140                 


His Pro Phe Gly Trp Pro Ser Asn Gly Phe Pro Gly Pro Gln Gly Pro 
145                 150                 155                 160 


Tyr Tyr Cys Gly Val Gly Ala Asp Arg Ala Tyr Gly Arg Asp Ile Val 
                165                 170                 175     


Glu Ala His Tyr Arg Ala Cys Leu Tyr Ala Gly Val Lys Ile Ala Gly 
            180                 185                 190         


Thr Asn Ala Glu Val Met Pro Ala Gln Trp Glu Phe Gln Ile Gly Pro 
        195                 200                 205             


Cys Glu Gly Ile Ser Met Gly Asp His Leu Trp Val Ala Arg Phe Ile 
    210                 215                 220                 


Leu His Arg Val Cys Glu Asp Phe Gly Val Ile Ala Thr Phe Asp Pro 
225                 230                 235                 240 


Lys Pro Ile Pro Gly Asn Trp Asn Gly Ala Gly Cys His Thr Asn Phe 
                245                 250                 255     


Ser Thr Lys Ala Met Arg Glu Glu Asn Gly Leu Lys Tyr Ile Glu Glu 
            260                 265                 270         


Ala Ile Glu Lys Leu Ser Lys Arg His Gln Tyr His Ile Arg Ala Tyr 
        275                 280                 285             


Asp Pro Lys Gly Gly Leu Asp Asn Ala Arg Arg Leu Thr Gly Phe His 
    290                 295                 300                 


Glu Thr Ser Asn Ile Asn Asp Phe Ser Ala Gly Val Ala Asn Arg Ser 
305                 310                 315                 320 


Ala Ser Ile Arg Ile Pro Arg Thr Val Gly Gln Glu Lys Lys Gly Tyr 
                325                 330                 335     


Phe Glu Asp Arg Arg Pro Ser Ala Asn Cys Asp Pro Phe Ser Val Thr 
            340                 345                 350         


Glu Ala Leu Ile Arg Thr Cys Leu Leu Asn Glu Thr Gly Asp Glu Pro 
        355                 360                 365             


Phe Gln Tyr Lys Asn 
    370             


<210>  56
<211>  80
<212>  DNA
<213>  Synthetic oligo

<400>  56
gaggatccca gaaccagcgc catcagcgtt accatggcac cagctacaac cttgaaccaa       60

ttaaccctca ctaaagggcg                                                   80


<210>  57
<211>  81
<212>  DNA
<213>  Synthetic oligo

<400>  57
gtggatccgc gatatcgtga aacagcgcgg cgatgaaaat cagctcagtt gacggcagta       60

atacgactca ctatagggct c                                                 81


<210>  58
<211>  80
<212>  DNA
<213>  Synthetic oligo

<400>  58
gaggatcctg cgcctgtttg aactgacgca gcgcctcaag ctgttgctct tcgtcatcaa       60

ttaaccctca ctaaagggcg                                                   80


<210>  59
<211>  81
<212>  DNA
<213>  Synthetic oligo

<400>  59
gtggatccag gtgttccagc tcattcgcgg cggacgcgaa ccgtcgctgc aatcgcgcta       60

atacgactca ctatagggct c                                                 81


