                         SEQUENCE LISTING

<110>  SynImmune GmbH
 
<120>  FLT3 Antibodies

<130>  P45481

<150>  US 61/289,529
<151>  2009-12-23

<160>  68    

<170>  PatentIn version 3.5

<210>  1
<211>  11
<212>  PRT
<213>  Artificial

<220>
<223>  4G8 VL CDR1

<400>  1

Arg Ala Ser Gln Ser Ile Ser Asn Asn Leu His 
1               5                   10      


<210>  2
<211>  7
<212>  PRT
<213>  Artificial

<220>
<223>  4G8 VL CDR2

<400>  2

Tyr Ala Ser Gln Ser Ile Ser 
1               5           


<210>  3
<211>  9
<212>  PRT
<213>  Artificial

<220>
<223>  4G8 VL CDR3

<400>  3

Gln Gln Ser Asn Thr Trp Pro Tyr Thr 
1               5                   


<210>  4
<211>  5
<212>  PRT
<213>  Artificial

<220>
<223>  4G8 VH CDR1

<400>  4

Ser Tyr Trp Met His 
1               5   


<210>  5
<211>  17
<212>  PRT
<213>  Artificial

<220>
<223>  4G8 VH CDR2

<400>  5

Glu Ile Asp Pro Ser Asp Ser Tyr Lys Asp Tyr Asn Gln Lys Phe Lys 
1               5                   10                  15      


Asp 
    


<210>  6
<211>  9
<212>  PRT
<213>  Artificial

<220>
<223>  4G8 VH CDR3

<400>  6

Ala Ile Thr Thr Thr Pro Phe Asp Phe 
1               5                   


<210>  7
<211>  17
<212>  PRT
<213>  Artificial

<220>
<223>  BV10 VL CDR1

<400>  7

Lys Ser Ser Gln Ser Leu Leu Asn Ser Gly Asn Gln Lys Asn Tyr Met 
1               5                   10                  15      


Ala 
    


<210>  8
<211>  7
<212>  PRT
<213>  Artificial

<220>
<223>  BV10 VL CDR2

<400>  8

Gly Ala Ser Thr Arg Glu Ser 
1               5           


<210>  9
<211>  9
<212>  PRT
<213>  Artificial

<220>
<223>  BV10 VL CDR3

<400>  9

Gln Asn Asp His Ser Tyr Pro Leu Thr 
1               5                   


<210>  10
<211>  5
<212>  PRT
<213>  Artificial

<220>
<223>  BV10 VH CDR1

<400>  10

Asn Tyr Gly Leu His 
1               5   


<210>  11
<211>  16
<212>  PRT
<213>  Artificial

<220>
<223>  BV10 VH CDR2

<400>  11

Val Ile Trp Ser Gly Gly Ser Thr Asp Tyr Asn Ala Ala Phe Ile Ser 
1               5                   10                  15      


<210>  12
<211>  15
<212>  PRT
<213>  Artificial

<220>
<223>  BV10 VH CDR3

<400>  12

Lys Gly Gly Ile Tyr Tyr Ala Asn His Tyr Tyr Ala Met Asp Tyr 
1               5                   10                  15  


<210>  13
<211>  108
<212>  PRT
<213>  Artificial

<220>
<223>  4G8 VL VJ Segment

<400>  13

Asp Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Val Thr Pro Gly 
1               5                   10                  15      


Asp Ser Val Ser Leu Ser Cys Arg Ala Ser Gln Ser Ile Ser Asn Asn 
            20                  25                  30          


Leu His Trp Tyr Gln Gln Lys Ser His Glu Ser Pro Arg Leu Leu Ile 
        35                  40                  45              


Lys Tyr Ala Ser Gln Ser Ile Ser Gly Ile Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Ser Ile Asn Ser Val Glu Thr 
65                  70                  75                  80  


Glu Asp Phe Gly Val Tyr Phe Cys Gln Gln Ser Asn Thr Trp Pro Tyr 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Arg 
            100                 105             


<210>  14
<211>  118
<212>  PRT
<213>  Artificial

<220>
<223>  4G8 VH VDJ Segment

<400>  14

Gln Val Gln Leu Gln Gln Pro Gly Ala Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Leu Lys Leu Ser Cys Lys Ser Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Trp Met His Trp Val Arg Gln Arg Pro Gly His Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Glu Ile Asp Pro Ser Asp Ser Tyr Lys Asp Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Asp Lys Ala Thr Leu Thr Val Asp Arg Ser Ser Asn Thr Ala Tyr 
65                  70                  75                  80  


Met His Leu Ser Ser Leu Thr Ser Asp Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ala Ile Thr Thr Thr Pro Phe Asp Phe Trp Gly Gln Gly Thr 
            100                 105                 110         


Thr Leu Thr Val Ser Ser 
        115             


<210>  15
<211>  234
<212>  PRT
<213>  Mus musculus

<400>  15

Met Val Phe Thr Pro Gln Ile Leu Gly Leu Met Leu Phe Trp Ile Ser 
1               5                   10                  15      


Ala Ser Arg Gly Asp Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser 
            20                  25                  30          


Val Thr Pro Gly Asp Ser Val Ser Leu Ser Cys Arg Ala Ser Gln Ser 
        35                  40                  45              


Ile Ser Asn Asn Leu His Trp Tyr Gln Gln Lys Ser His Glu Ser Pro 
    50                  55                  60                  


Arg Leu Leu Ile Lys Tyr Ala Ser Gln Ser Ile Ser Gly Ile Pro Ser 
65                  70                  75                  80  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Ser Ile Asn 
                85                  90                  95      


Ser Val Glu Thr Glu Asp Phe Gly Val Tyr Phe Cys Gln Gln Ser Asn 
            100                 105                 110         


Thr Trp Pro Tyr Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Arg 
        115                 120                 125             


Ala Asp Ala Ala Pro Thr Val Ser Ile Phe Pro Pro Ser Ser Glu Gln 
    130                 135                 140                 


Leu Thr Ser Gly Gly Ala Ser Val Val Cys Phe Leu Asn Asn Phe Tyr 
145                 150                 155                 160 


Pro Lys Asp Ile Asn Val Lys Trp Lys Ile Asp Gly Ser Glu Arg Gln 
                165                 170                 175     


Asn Gly Val Leu Asn Ser Trp Thr Asp Gln Asp Ser Lys Asp Ser Thr 
            180                 185                 190         


Tyr Ser Met Ser Ser Thr Leu Thr Leu Thr Lys Asp Glu Tyr Glu Arg 
        195                 200                 205             


His Asn Ser Tyr Thr Cys Glu Ala Thr His Lys Thr Ser Thr Ser Pro 
    210                 215                 220                 


Ile Val Lys Ser Phe Asn Arg Asn Glu Cys 
225                 230                 


<210>  16
<211>  461
<212>  PRT
<213>  Mus musculus

<400>  16

Met Gly Trp Ser Cys Ile Ile Leu Phe Leu Val Ser Thr Ala Thr Gly 
1               5                   10                  15      


Val His Ser Gln Val Gln Leu Gln Gln Pro Gly Ala Glu Leu Val Lys 
            20                  25                  30          


Pro Gly Ala Ser Leu Lys Leu Ser Cys Lys Ser Ser Gly Tyr Thr Phe 
        35                  40                  45              


Thr Ser Tyr Trp Met His Trp Val Arg Gln Arg Pro Gly His Gly Leu 
    50                  55                  60                  


Glu Trp Ile Gly Glu Ile Asp Pro Ser Asp Ser Tyr Lys Asp Tyr Asn 
65                  70                  75                  80  


Gln Lys Phe Lys Asp Lys Ala Thr Leu Thr Val Asp Arg Ser Ser Asn 
                85                  90                  95      


Thr Ala Tyr Met His Leu Ser Ser Leu Thr Ser Asp Asp Ser Ala Val 
            100                 105                 110         


Tyr Tyr Cys Ala Arg Ala Ile Thr Thr Thr Pro Phe Asp Phe Trp Gly 
        115                 120                 125             


Gln Gly Thr Thr Leu Thr Val Ser Ser Ala Lys Thr Thr Pro Pro Ser 
    130                 135                 140                 


Val Tyr Pro Leu Ala Pro Gly Ser Ala Ala Gln Thr Asn Ser Met Val 
145                 150                 155                 160 


Thr Leu Gly Cys Leu Val Lys Gly Tyr Phe Pro Glu Pro Val Thr Val 
                165                 170                 175     


Thr Trp Asn Ser Gly Ser Leu Ser Ser Gly Val His Thr Phe Pro Ala 
            180                 185                 190         


Val Leu Gln Ser Asp Leu Tyr Thr Leu Ser Ser Ser Val Thr Val Pro 
        195                 200                 205             


Ser Ser Thr Trp Pro Ser Glu Thr Val Thr Cys Asn Val Ala His Pro 
    210                 215                 220                 


Ala Ser Ser Thr Lys Val Asp Lys Lys Ile Val Pro Arg Asp Cys Gly 
225                 230                 235                 240 


Cys Lys Pro Cys Ile Cys Thr Val Pro Glu Val Ser Ser Val Phe Ile 
                245                 250                 255     


Phe Pro Pro Lys Pro Lys Asp Val Leu Thr Ile Thr Leu Thr Pro Lys 
            260                 265                 270         


Val Thr Cys Val Val Val Asp Ile Ser Lys Asp Asp Pro Glu Val Gln 
        275                 280                 285             


Phe Ser Trp Phe Val Asp Asp Val Glu Val His Thr Ala Gln Thr Gln 
    290                 295                 300                 


Pro Arg Glu Glu Gln Phe Asn Ser Thr Phe Arg Ser Val Ser Glu Leu 
305                 310                 315                 320 


Pro Ile Met His Gln Asp Trp Leu Asn Gly Lys Glu Phe Lys Cys Arg 
                325                 330                 335     


Val Asn Ser Ala Ala Phe Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys 
            340                 345                 350         


Thr Lys Gly Arg Pro Lys Ala Pro Gln Val Tyr Thr Ile Pro Pro Pro 
        355                 360                 365             


Lys Glu Gln Met Ala Lys Asp Lys Val Ser Leu Thr Cys Met Ile Thr 
    370                 375                 380                 


Asp Phe Phe Pro Glu Asp Ile Thr Val Glu Trp Gln Trp Asn Gly Gln 
385                 390                 395                 400 


Pro Ala Glu Asn Tyr Lys Asn Thr Gln Pro Ile Met Asp Thr Asp Gly 
                405                 410                 415     


Ser Tyr Phe Val Tyr Ser Lys Leu Asn Val Gln Lys Ser Asn Trp Glu 
            420                 425                 430         


Ala Gly Asn Thr Phe Thr Cys Ser Val Leu His Glu Gly Leu His Asn 
        435                 440                 445             


His His Thr Glu Lys Ser Leu Ser His Ser Pro Gly Lys 
    450                 455                 460     


<210>  17
<211>  324
<212>  DNA
<213>  Artificial

<220>
<223>  4G8 VL VJ Segment CDS

<400>  17
gatattgtgc taactcagtc tccagccacc ctgtctgtga ctccaggaga tagcgtcagt       60

ctttcctgca gggccagcca gagtattagc aacaacctac actggtatca acaaaaatca      120

catgagtctc caaggcttct catcaagtat gcttcccagt ccatctctgg gatcccctcc      180

aggttcagtg gcagtggatc agggacagat ttcactctca gtatcaacag tgtggagact      240

gaagattttg gagtgtattt ctgtcaacag agtaacacct ggccgtacac gttcggaggg      300

gggaccaagc tggaaataaa acgg                                             324


<210>  18
<211>  354
<212>  DNA
<213>  Artificial

<220>
<223>  4G8 VH VDJ Segment CDS

<400>  18
caggtccaac tgcagcagcc tggggctgag cttgtgaagc ctggggcttc attgaagctg       60

tcctgcaagt cttccgggta caccttcacc agctactgga tgcactgggt gaggcagagg      120

cctggacatg gccttgagtg gatcggagag attgatcctt ctgacagtta taaagactac      180

aatcagaagt tcaaggacaa ggccacattg actgtggaca gatcctccaa cacagcctac      240

atgcacctca gcagcctgac atctgatgac tctgcggtct attattgtgc aagagcgatt      300

acgacgaccc cctttgactt ctggggccaa ggcaccactc tcacagtctc ctca            354


<210>  19
<211>  705
<212>  DNA
<213>  Mus musculus

<400>  19
atggttttca cacctcagat acttggactt atgctttttt ggatttcagc ctccagaggt       60

gatattgtgc taactcagtc tccagccacc ctgtctgtga ctccaggaga tagcgtcagt      120

ctttcctgca gggccagcca gagtattagc aacaacctac actggtatca acaaaaatca      180

catgagtctc caaggcttct catcaagtat gcttcccagt ccatctctgg gatcccctcc      240

aggttcagtg gcagtggatc agggacagat ttcactctca gtatcaacag tgtggagact      300

gaagattttg gagtgtattt ctgtcaacag agtaacacct ggccgtacac gttcggaggg      360

gggaccaagc tggaaataaa acgggctgat gctgcaccaa ctgtatccat cttcccacca      420

tccagtgagc agttaacatc tggaggtgcc tcagtcgtgt gcttcttgaa caacttctac      480

cccaaagaca tcaatgtcaa gtggaagatt gatggcagtg aacgacaaaa tggcgtcctg      540

aacagttgga ctgatcagga cagcaaagac agcacctaca gcatgagcag caccctcacg      600

ttgaccaagg acgagtatga acgacataac agctatacct gtgaggccac tcacaagaca      660

tcaacttcac ccattgtcaa gagcttcaac aggaatgagt gttag                      705


<210>  20
<211>  948
<212>  DNA
<213>  Mus musculus

<400>  20
ctcagggaaa gctcgaagat ggttttcaca cctcagatac ttggacttat gcttttttgg       60

atttcagcct ccagaggtga tattgtgcta actcagtctc cagccaccct gtctgtgact      120

ccaggagata gcgtcagtct ttcctgcagg gccagccaga gtattagcaa caacctacac      180

tggtatcaac aaaaatcaca tgagtctcca aggcttctca tcaagtatgc ttcccagtcc      240

atctctggga tcccctccag gttcagtggc agtggatcag ggacagattt cactctcagt      300

atcaacagtg tggagactga agattttgga gtgtatttct gtcaacagag taacacctgg      360

ccgtacacgt tcggaggggg gaccaagctg gaaataaaac gggctgatgc tgcaccaact      420

gtatccatct tcccaccatc cagtgagcag ttaacatctg gaggtgcctc agtcgtgtgc      480

ttcttgaaca acttctaccc caaagacatc aatgtcaagt ggaagattga tggcagtgaa      540

cgacaaaatg gcgtcctgaa cagttggact gatcaggaca gcaaagacag cacctacagc      600

atgagcagca ccctcacgtt gaccaaggac gagtatgaac gacataacag ctatacctgt      660

gaggccactc acaagacatc aacttcaccc attgtcaaga gcttcaacag gaatgagtgt      720

tagagacaaa ggtcctgaga cgccaccacc agctccccag ctccatccta tcttcccttc      780

taaggtcttg gaggcttccc cacaagcgac ctaccactgt tgcggtgctc caaacctcct      840

ccccacctcc ttctcctcct cctccctttc cttggctttt atcatgctaa tatttgcaga      900

aaatattcaa taaagtgagt ctttgcactt gaaaaaaaaa aaaaaaaa                   948


<210>  21
<211>  1386
<212>  DNA
<213>  Mus musculus

<400>  21
atgggatgga gctgtatcat cctcttcttg gtatcaacag ctacaggtgt ccactcccag       60

gtccaactgc agcagcctgg ggctgagctt gtgaagcctg gggcttcatt gaagctgtcc      120

tgcaagtctt ccgggtacac cttcaccagc tactggatgc actgggtgag gcagaggcct      180

ggacatggcc ttgagtggat cggagagatt gatccttctg acagttataa agactacaat      240

cagaagttca aggacaaggc cacattgact gtggacagat cctccaacac agcctacatg      300

cacctcagca gcctgacatc tgatgactct gcggtctatt attgtgcaag agcgattacg      360

acgaccccct ttgacttctg gggccaaggc accactctca cagtctcctc agccaaaacg      420

acacccccat ctgtctatcc actggcccct ggatctgctg cccaaactaa ctccatggtg      480

accctgggat gcctggtcaa gggctatttc cctgagccag tgacagtgac ctggaactct      540

ggatccctgt ccagcggtgt gcacaccttc ccagctgtcc tgcagtctga cctctacact      600

ctgagcagct cagtgactgt cccctccagc acctggccca gcgagaccgt cacctgcaac      660

gttgcccacc cggccagcag caccaaggtg gacaagaaaa ttgtgcccag ggattgtggt      720

tgtaagcctt gcatatgtac agtcccagaa gtatcatctg tcttcatctt ccccccaaag      780

cccaaggatg tgctcaccat tactctgact cctaaggtca cgtgtgttgt ggtagacatc      840

agcaaggatg atcccgaggt ccagttcagc tggtttgtag atgatgtgga ggtgcacaca      900

gctcagacgc aaccccggga ggagcagttc aacagcactt tccgctcagt cagtgaactt      960

cccatcatgc accaggactg gctcaatggc aaggagttca aatgcagggt caacagtgca     1020

gctttccctg cccccatcga gaaaaccatc tccaaaacca aaggcagacc gaaggctcca     1080

caggtgtaca ccattccacc tcccaaggag cagatggcca aggataaagt cagtctgacc     1140

tgcatgataa cagacttctt ccctgaagac attactgtgg agtggcagtg gaatgggcag     1200

ccagcggaga actacaagaa cactcagccc atcatggaca cagatggctc ttacttcgtc     1260

tacagcaagc tcaatgtgca gaagagcaac tgggaggcag gaaatacttt cacctgctct     1320

gtgttacatg agggcctgca caaccaccat actgagaaga gcctctccca ctctcctggt     1380

aaatga                                                                1386


<210>  22
<211>  1593
<212>  DNA
<213>  Mus musculus

<400>  22
gttcgttatc ggaattaacc agacaaatcg ctccaccaac taagaacggc cctgttctct       60

ctacagttac tgagcacaca ggacctcacc atgggatgga gctgtatcat cctcttcttg      120

gtatcaacag ctacaggtgt ccactcccag gtccaactgc agcagcctgg ggctgagctt      180

gtgaagcctg gggcttcatt gaagctgtcc tgcaagtctt ccgggtacac cttcaccagc      240

tactggatgc actgggtgag gcagaggcct ggacatggcc ttgagtggat cggagagatt      300

gatccttctg acagttataa agactacaat cagaagttca aggacaaggc cacattgact      360

gtggacagat cctccaacac agcctacatg cacctcagca gcctgacatc tgatgactct      420

gcggtctatt attgtgcaag agcgattacg acgaccccct ttgacttctg gggccaaggc      480

accactctca cagtctcctc agccaaaacg acacccccat ctgtctatcc actggcccct      540

ggatctgctg cccaaactaa ctccatggtg accctgggat gcctggtcaa gggctatttc      600

cctgagccag tgacagtgac ctggaactct ggatccctgt ccagcggtgt gcacaccttc      660

ccagctgtcc tgcagtctga cctctacact ctgagcagct cagtgactgt cccctccagc      720

acctggccca gcgagaccgt cacctgcaac gttgcccacc cggccagcag caccaaggtg      780

gacaagaaaa ttgtgcccag ggattgtggt tgtaagcctt gcatatgtac agtcccagaa      840

gtatcatctg tcttcatctt ccccccaaag cccaaggatg tgctcaccat tactctgact      900

cctaaggtca cgtgtgttgt ggtagacatc agcaaggatg atcccgaggt ccagttcagc      960

tggtttgtag atgatgtgga ggtgcacaca gctcagacgc aaccccggga ggagcagttc     1020

aacagcactt tccgctcagt cagtgaactt cccatcatgc accaggactg gctcaatggc     1080

aaggagttca aatgcagggt caacagtgca gctttccctg cccccatcga gaaaaccatc     1140

tccaaaacca aaggcagacc gaaggctcca caggtgtaca ccattccacc tcccaaggag     1200

cagatggcca aggataaagt cagtctgacc tgcatgataa cagacttctt ccctgaagac     1260

attactgtgg agtggcagtg gaatgggcag ccagcggaga actacaagaa cactcagccc     1320

atcatggaca cagatggctc ttacttcgtc tacagcaagc tcaatgtgca gaagagcaac     1380

tgggaggcag gaaatacttt cacctgctct gtgttacatg agggcctgca caaccaccat     1440

actgagaaga gcctctccca ctctcctggt aaatgatccc agtgtccttg gagccctctg     1500

gtcctacagg actctgacac ctacctccac ccctccctgt ataaataaag cacccagcac     1560

tgccttggga ccctgcaaaa aaaaaaaaaa aaa                                  1593


<210>  23
<211>  234
<212>  PRT
<213>  Artificial

<220>
<223>  4G8 chimeric kappa light chain

<400>  23

Met Val Phe Thr Pro Gln Ile Leu Gly Leu Met Leu Phe Trp Ile Ser 
1               5                   10                  15      


Gly Ala Arg Gly Asp Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser 
            20                  25                  30          


Val Thr Pro Gly Asp Ser Val Ser Leu Ser Cys Arg Ala Ser Gln Ser 
        35                  40                  45              


Ile Ser Asn Asn Leu His Trp Tyr Gln Gln Lys Ser His Glu Ser Pro 
    50                  55                  60                  


Arg Leu Leu Ile Lys Tyr Ala Ser Gln Ser Ile Ser Gly Ile Pro Ser 
65                  70                  75                  80  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Ser Ile Asn 
                85                  90                  95      


Ser Val Glu Thr Glu Asp Phe Gly Val Tyr Phe Cys Gln Gln Ser Asn 
            100                 105                 110         


Thr Trp Pro Tyr Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Arg 
        115                 120                 125             


Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln 
    130                 135                 140                 


Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr 
145                 150                 155                 160 


Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser 
                165                 170                 175     


Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr 
            180                 185                 190         


Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys 
        195                 200                 205             


His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro 
    210                 215                 220                 


Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
225                 230                 


<210>  24
<211>  705
<212>  DNA
<213>  Artificial

<220>
<223>  4G8 chimeric kappa light chain CDS

<400>  24
atggttttca cacctcagat acttggactt atgctttttt ggatttcagg tgctcgagga       60

gatattgtgc taactcagtc tccagccacc ctgtctgtga ctccaggaga tagcgtcagt      120

ctttcctgca gggccagcca gagtattagc aacaacctac actggtatca acaaaaatca      180

catgagtctc caaggcttct catcaagtat gcttcccagt ccatctctgg gatcccctcc      240

aggttcagtg gcagtggatc agggacagat ttcactctca gtatcaacag tgtggagact      300

gaagattttg gagtgtattt ctgtcaacag agtaacacct ggccgtacac gttcggaggg      360

gggaccaagc tggaaataaa acggactgtg gctgcaccat ctgtcttcat cttcccgcca      420

tctgatgagc agttgaaatc tggaactgcc tctgttgtgt gcctgctgaa taacttctat      480

cccagagagg ccaaagtaca gtggaaggtg gataacgccc tccaatcggg taactcccag      540

gagagtgtca cagagcagga cagcaaggac agcacctaca gcctcagcag caccctgacg      600

ctgagcaaag cagactacga gaaacacaaa gtctacgcct gcgaagtcac ccatcagggc      660

ctgagctcgc ccgtcacaaa gagcttcaac aggggagagt gttag                      705


<210>  25
<211>  467
<212>  PRT
<213>  Artificial

<220>
<223>  4G8 chimeric IgG gamma 1 heavy chain

<400>  25

Met Gly Trp Ser Trp Ile Phe Leu Phe Leu Leu Ser Gly Thr Ala Gly 
1               5                   10                  15      


Val Leu Ser Gln Val Gln Leu Gln Gln Pro Gly Ala Glu Leu Val Lys 
            20                  25                  30          


Pro Gly Ala Ser Leu Lys Leu Ser Cys Lys Ser Ser Gly Tyr Thr Phe 
        35                  40                  45              


Thr Ser Tyr Trp Met His Trp Val Arg Gln Arg Pro Gly His Gly Leu 
    50                  55                  60                  


Glu Trp Ile Gly Glu Ile Asp Pro Ser Asp Ser Tyr Lys Asp Tyr Asn 
65                  70                  75                  80  


Gln Lys Phe Lys Asp Lys Ala Thr Leu Thr Val Asp Arg Ser Ser Asn 
                85                  90                  95      


Thr Ala Tyr Met His Leu Ser Ser Leu Thr Ser Asp Asp Ser Ala Val 
            100                 105                 110         


Tyr Tyr Cys Ala Arg Ala Ile Thr Thr Thr Pro Phe Asp Phe Trp Gly 
        115                 120                 125             


Gln Gly Thr Thr Leu Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser 
    130                 135                 140                 


Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala 
145                 150                 155                 160 


Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val 
                165                 170                 175     


Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala 
            180                 185                 190         


Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val 
        195                 200                 205             


Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His 
    210                 215                 220                 


Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys 
225                 230                 235                 240 


Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly 
                245                 250                 255     


Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
            260                 265                 270         


Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 
        275                 280                 285             


Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
    290                 295                 300                 


His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr 
305                 310                 315                 320 


Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 
                325                 330                 335     


Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile 
            340                 345                 350         


Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 
        355                 360                 365             


Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser 
    370                 375                 380                 


Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
385                 390                 395                 400 


Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
                405                 410                 415     


Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val 
            420                 425                 430         


Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met 
        435                 440                 445             


His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
    450                 455                 460                 


Pro Gly Lys 
465         


<210>  26
<211>  1407
<212>  DNA
<213>  Artificial

<220>
<223>  4G8 chimeric IgG gamma 1 heavy chain CDS

<400>  26
atgggatgga gctggatctt tctctttctc ctgtcaggaa ctgcaggtgt cctctctcag       60

gtccaactgc agcagcctgg ggctgagctt gtgaagcctg gggcttcatt gaagctgtcc      120

tgcaagtctt ccgggtacac cttcaccagc tactggatgc actgggtgag gcagaggcct      180

ggacatggcc ttgagtggat cggagagatt gatccttctg acagttataa agactacaat      240

cagaagttca aggacaaggc cacattgact gtggacagat cctccaacac agcctacatg      300

cacctcagca gcctgacatc tgatgactct gcggtctatt attgtgcaag agcgattacg      360

acgaccccct ttgacttctg gggccaaggc accactctca cagtctcctc agcctccacc      420

aagggcccat cggtcttccc cctggcaccc tcctccaaga gcacctctgg gggcacagcg      480

gccctgggct gtctggtcaa ggactacttc cccgaaccgg tgacggtgtc gtggaactca      540

ggcgccctga ccagcggcgt gcacaccttc ccggctgtcc tacagtcctc aggactctac      600

tccctcagca gcgtggtgac cgtgccctcc agcagcttgg gcacccagac ctacatctgc      660

aacgtgaatc acaagcccag caacaccaag gtggacaaga aagttgagcc caaatcttgt      720

gacaaaactc acacatgccc accgtgccca gcacctgaac tcctgggggg cccgtcagtc      780

ttcctcttcc ccccaaaacc caaggacacc ctcatgatct cccggacccc tgaggtcaca      840

tgcgtggtgg tggacgtgag ccacgaagac cctgaggtca agttcaactg gtacgtggac      900

ggcgtggagg tgcataatgc caagacaaag ccgcgggagg agcagtacaa cagcacgtat      960

cgtgtggtca gcgtcctcac cgtcctgcac caggactggc tgaatggcaa ggagtacaag     1020

tgcaaggtct ccaacaaagc cctcccagcc cccatcgaga aaaccatctc caaagccaaa     1080

gggcagcccc gagaaccaca ggtgtacacc ctgcccccat cccgggatga gctgaccaag     1140

aaccaggtca gcctgacctg cctggtcaaa ggcttctatc ccagcgacat cgccgtggag     1200

tgggagagca atgggcagcc ggagaacaac tacaagacca cgcctcccgt gctggactcc     1260

gacggctcct tcttcctcta cagcaagctc accgtggaca agagcaggtg gcagcagggg     1320

aacgtcttct catgctccgt gatgcatgag gctctgcaca accactacac gcagaagagc     1380

ctctccctgt ctccgggtaa atgataa                                         1407


<210>  27
<211>  467
<212>  PRT
<213>  Artificial

<220>
<223>  SDIE 4G8 heavy chain

<400>  27

Met Gly Trp Ser Trp Ile Phe Leu Phe Leu Leu Ser Gly Thr Ala Gly 
1               5                   10                  15      


Val Leu Ser Gln Val Gln Leu Gln Gln Pro Gly Ala Glu Leu Val Lys 
            20                  25                  30          


Pro Gly Ala Ser Leu Lys Leu Ser Cys Lys Ser Ser Gly Tyr Thr Phe 
        35                  40                  45              


Thr Ser Tyr Trp Met His Trp Val Arg Gln Arg Pro Gly His Gly Leu 
    50                  55                  60                  


Glu Trp Ile Gly Glu Ile Asp Pro Ser Asp Ser Tyr Lys Asp Tyr Asn 
65                  70                  75                  80  


Gln Lys Phe Lys Asp Lys Ala Thr Leu Thr Val Asp Arg Ser Ser Asn 
                85                  90                  95      


Thr Ala Tyr Met His Leu Ser Ser Leu Thr Ser Asp Asp Ser Ala Val 
            100                 105                 110         


Tyr Tyr Cys Ala Arg Ala Ile Thr Thr Thr Pro Phe Asp Phe Trp Gly 
        115                 120                 125             


Gln Gly Thr Thr Leu Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser 
    130                 135                 140                 


Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala 
145                 150                 155                 160 


Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val 
                165                 170                 175     


Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala 
            180                 185                 190         


Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val 
        195                 200                 205             


Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His 
    210                 215                 220                 


Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys 
225                 230                 235                 240 


Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly 
                245                 250                 255     


Gly Pro Asp Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
            260                 265                 270         


Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 
        275                 280                 285             


Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
    290                 295                 300                 


His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr 
305                 310                 315                 320 


Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 
                325                 330                 335     


Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Glu 
            340                 345                 350         


Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 
        355                 360                 365             


Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser 
    370                 375                 380                 


Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
385                 390                 395                 400 


Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
                405                 410                 415     


Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val 
            420                 425                 430         


Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met 
        435                 440                 445             


His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
    450                 455                 460                 


Pro Gly Lys 
465         


<210>  28
<211>  1407
<212>  DNA
<213>  Artificial

<220>
<223>  SDIE 4G8 heavy chain CDS

<400>  28
atgggatgga gctggatctt tctctttctc ctgtcaggaa ctgcaggtgt cctctctcag       60

gtccaactgc agcagcctgg ggctgagctt gtgaagcctg gggcttcatt gaagctgtcc      120

tgcaagtctt ccgggtacac cttcaccagc tactggatgc actgggtgag gcagaggcct      180

ggacatggcc ttgagtggat cggagagatt gatccttctg acagttataa agactacaat      240

cagaagttca aggacaaggc cacattgact gtggacagat cctccaacac agcctacatg      300

cacctcagca gcctgacatc tgatgactct gcggtctatt attgtgcaag agcgattacg      360

acgaccccct ttgacttctg gggccaaggc accactctca cagtctcctc agcctccacc      420

aagggcccat cggtcttccc cctggcaccc tcctccaaga gcacctctgg gggcacagcg      480

gccctgggct gtctggtcaa ggactacttc cccgaaccgg tgacggtgtc gtggaactca      540

ggcgccctga ccagcggcgt gcacaccttc ccggctgtcc tacagtcctc aggactctac      600

tccctcagca gcgtggtgac cgtgccctcc agcagcttgg gcacccagac ctacatctgc      660

aacgtgaatc acaagcccag caacaccaag gtggacaaga aagttgagcc caaatcttgt      720

gacaaaactc acacatgccc accgtgccca gcacctgaac tcctgggggg cccggatgtc      780

ttcctcttcc ccccaaaacc caaggacacc ctcatgatct cccggacccc tgaggtcaca      840

tgcgtggtgg tggacgtgag ccacgaagac cctgaggtca agttcaactg gtacgtggac      900

ggcgtggagg tgcataatgc caagacaaag ccgcgggagg agcagtacaa cagcacgtat      960

cgtgtggtca gcgtcctcac cgtcctgcac caggactggc tgaatggcaa ggagtacaag     1020

tgcaaggtct ccaacaaagc cctcccagcc cccgaggaga aaaccatctc caaagccaaa     1080

gggcagcccc gagaaccaca ggtgtacacc ctgcccccat cccgggatga gctgaccaag     1140

aaccaggtca gcctgacctg cctggtcaaa ggcttctatc ccagcgacat cgccgtggag     1200

tgggagagca atgggcagcc ggagaacaac tacaagacca cgcctcccgt gctggactcc     1260

gacggctcct tcttcctcta cagcaagctc accgtggaca agagcaggtg gcagcagggg     1320

aacgtcttct catgctccgt gatgcatgag gctctgcaca accactacac gcagaagagc     1380

ctctccctgt ctccgggtaa atgataa                                         1407


<210>  29
<211>  113
<212>  PRT
<213>  Artificial

<220>
<223>  BV10 VL VJ Segment

<400>  29

Asp Ile Val Met Thr Gln Ser Pro Ser Ser Leu Ser Val Ser Ala Gly 
1               5                   10                  15      


Glu Lys Val Thr Met Ser Cys Lys Ser Ser Gln Ser Leu Leu Asn Ser 
            20                  25                  30          


Gly Asn Gln Lys Asn Tyr Met Ala Tyr Gln Gln Lys Pro Gly Gln Pro 
        35                  40                  45              


Pro Lys Leu Leu Ile Tyr Gly Ala Ser Thr Arg Glu Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile 
65                  70                  75                  80  


Ser Ser Val Gln Ala Glu Asp Leu Ala Val Tyr Tyr Cys Gln Asn Asp 
                85                  90                  95      


His Ser Tyr Pro Leu Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys 
            100                 105                 110         


Arg 
    


<210>  30
<211>  123
<212>  PRT
<213>  Artificial

<220>
<223>  BV10 VH VDJ Segment

<400>  30

Gln Val Gln Leu Lys Gln Ser Gly Pro Gly Leu Val Gln Pro Ser Gln 
1               5                   10                  15      


Ser Leu Ser Ile Thr Cys Thr Val Ser Gly Phe Ser Leu Thr Asn Tyr 
            20                  25                  30          


Gly Leu His Trp Val Arg Gln Ser Pro Gly Lys Gly Leu Glu Trp Leu 
        35                  40                  45              


Gly Val Ile Trp Ser Gly Gly Ser Thr Asp Tyr Asn Ala Ala Phe Ile 
    50                  55                  60                  


Ser Arg Leu Ser Ile Ser Lys Asp Asn Ser Lys Ser Gln Val Phe Phe 
65                  70                  75                  80  


Lys Met Asn Ser Leu Gln Ala Asp Asp Thr Ala Ile Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Lys Gly Gly Ile Tyr Tyr Ala Asn His Tyr Tyr Ala Met Asp Tyr 
            100                 105                 110         


Trp Gly Gln Gly Thr Ser Val Thr Val Ser Ser 
        115                 120             


<210>  31
<211>  240
<212>  PRT
<213>  Mus musculus

<400>  31

Met Glu Ser Gln Thr Gln Val Leu Ile Ser Leu Leu Phe Trp Val Ser 
1               5                   10                  15      


Gly Thr Cys Gly Asp Ile Val Met Thr Gln Ser Pro Ser Ser Leu Ser 
            20                  25                  30          


Val Ser Ala Gly Glu Lys Val Thr Met Ser Cys Lys Ser Ser Gln Ser 
        35                  40                  45              


Leu Leu Asn Ser Gly Asn Gln Lys Asn Tyr Met Ala Trp Tyr Gln Gln 
    50                  55                  60                  


Lys Pro Gly Gln Pro Pro Lys Leu Leu Ile Tyr Gly Ala Ser Thr Arg 
65                  70                  75                  80  


Glu Ser Gly Val Pro Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp 
                85                  90                  95      


Phe Thr Leu Thr Ile Ser Ser Val Gln Ala Glu Asp Leu Ala Val Tyr 
            100                 105                 110         


Tyr Cys Gln Asn Asp His Ser Tyr Pro Leu Thr Phe Gly Ala Gly Thr 
        115                 120                 125             


Lys Leu Glu Leu Lys Arg Ala Asp Ala Ala Pro Thr Val Ser Ile Phe 
    130                 135                 140                 


Pro Pro Ser Ser Glu Gln Leu Thr Ser Gly Gly Ala Ser Val Val Cys 
145                 150                 155                 160 


Phe Leu Asn Asn Phe Tyr Pro Lys Asp Ile Asn Val Lys Trp Lys Ile 
                165                 170                 175     


Asp Gly Ser Glu Arg Gln Asn Gly Val Leu Asn Ser Trp Thr Asp Gln 
            180                 185                 190         


Asp Ser Lys Asp Ser Thr Tyr Ser Met Ser Ser Thr Leu Thr Leu Thr 
        195                 200                 205             


Lys Asp Glu Tyr Glu Arg His Asn Ser Tyr Thr Cys Glu Ala Thr His 
    210                 215                 220                 


Lys Thr Ser Thr Ser Pro Ile Val Lys Ser Phe Asn Arg Asn Glu Cys 
225                 230                 235                 240 


<210>  32
<211>  466
<212>  PRT
<213>  Artificial

<220>
<223>  BV10 IgG gamma 1 heavy chain mouse

<400>  32

Met Ala Val Leu Gly Leu Leu Phe Cys Leu Val Thr Phe Pro Ser Cys 
1               5                   10                  15      


Val Leu Ser Gln Val Gln Leu Lys Gln Ser Gly Pro Gly Leu Val Gln 
            20                  25                  30          


Pro Ser Gln Ser Leu Ser Ile Thr Cys Thr Val Ser Gly Phe Ser Leu 
        35                  40                  45              


Thr Asn Tyr Gly Leu His Trp Val Arg Gln Ser Pro Gly Lys Gly Leu 
    50                  55                  60                  


Glu Trp Leu Gly Val Ile Trp Ser Gly Gly Ser Thr Asp Tyr Asn Ala 
65                  70                  75                  80  


Ala Phe Ile Ser Arg Leu Ser Ile Ser Lys Asp Asn Ser Lys Ser Gln 
                85                  90                  95      


Val Phe Phe Lys Met Asn Ser Leu Gln Ala Asp Asp Thr Ala Ile Tyr 
            100                 105                 110         


Tyr Cys Ala Arg Lys Gly Gly Ile Tyr Tyr Ala Asn His Tyr Tyr Ala 
        115                 120                 125             


Met Asp Tyr Trp Gly Gln Gly Thr Ser Val Thr Val Ser Ser Ala Lys 
    130                 135                 140                 


Thr Thr Pro Pro Ser Val Tyr Pro Leu Ala Pro Gly Ser Ala Ala Gln 
145                 150                 155                 160 


Thr Asn Ser Met Val Thr Leu Gly Cys Leu Val Lys Gly Tyr Phe Pro 
                165                 170                 175     


Glu Pro Val Thr Val Thr Trp Asn Ser Gly Ser Leu Ser Ser Gly Val 
            180                 185                 190         


His Thr Phe Pro Ala Val Leu Glu Ser Asp Leu Tyr Thr Leu Ser Ser 
        195                 200                 205             


Ser Val Thr Val Pro Ser Ser Pro Arg Pro Ser Glu Thr Val Thr Cys 
    210                 215                 220                 


Asn Val Ala His Pro Ala Ser Ser Thr Lys Val Asp Lys Lys Ile Val 
225                 230                 235                 240 


Pro Arg Asp Cys Gly Cys Lys Pro Cys Ile Cys Thr Val Pro Glu Val 
                245                 250                 255     


Ser Ser Val Phe Ile Phe Pro Pro Lys Pro Lys Asp Val Leu Thr Ile 
            260                 265                 270         


Thr Leu Thr Pro Lys Val Thr Cys Val Val Val Asp Ile Ser Lys Asp 
        275                 280                 285             


Asp Pro Glu Val Gln Phe Ser Trp Phe Val Asp Asp Val Glu Val His 
    290                 295                 300                 


Thr Ala Gln Thr Gln Pro Arg Glu Glu Gln Phe Asn Ser Thr Phe Arg 
305                 310                 315                 320 


Ser Val Ser Glu Leu Pro Ile Met His Gln Asp Trp Leu Asn Gly Lys 
                325                 330                 335     


Glu Phe Lys Cys Arg Val Asn Ser Ala Ala Phe Pro Ala Pro Ile Glu 
            340                 345                 350         


Lys Thr Ile Ser Lys Thr Lys Gly Arg Pro Lys Ala Pro Gln Val Tyr 
        355                 360                 365             


Thr Ile Pro Pro Pro Lys Glu Gln Met Ala Lys Asp Lys Val Ser Leu 
    370                 375                 380                 


Thr Cys Met Ile Thr Asp Phe Phe Pro Glu Asp Ile Thr Val Glu Trp 
385                 390                 395                 400 


Gln Trp Asn Gly Gln Pro Ala Glu Asn Tyr Lys Asn Thr Gln Pro Ile 
                405                 410                 415     


Met Asn Thr Asn Gly Ser Tyr Phe Val Tyr Ser Lys Leu Asn Val Gln 
            420                 425                 430         


Lys Ser Asn Trp Glu Ala Gly Asn Thr Phe Thr Cys Ser Val Leu His 
        435                 440                 445             


Glu Gly Leu His Asn His His Thr Glu Lys Ser Leu Ser His Ser Pro 
    450                 455                 460                 


Gly Lys 
465     


<210>  33
<211>  342
<212>  DNA
<213>  Artificial

<220>
<223>  BV10 VL VJ Segment CDS

<400>  33
gacattgtga tgacacagtc tccatcctcc ctgagtgtgt cagcaggaga gaaggtcact       60

atgagctgca agtccagtca gagtctgtta aacagtggaa atcaaaagaa ctatatggcc      120

tggtatcagc agaaaccagg gcagcctcct aaactgttga tctacggggc atccactagg      180

gaatctgggg tccctgatcg cttcacaggc agtggatctg gaaccgattt cactcttacc      240

atcagcagtg tgcaggctga agacctggca gtttattact gtcagaatga tcatagttat      300

ccgctcacgt tcggtgctgg gaccaagctg gagctgaaac gg                         342


<210>  34
<211>  369
<212>  DNA
<213>  Artificial

<220>
<223>  BV10 VH VDJ Segment CDS

<400>  34
caggtgcagc tgaagcagtc aggacctggc ctagtgcagc cctcacagag cctgtccatc       60

acctgcacag tctctggttt ctcattaact aactatggtt tacactgggt tcgccagtct      120

ccaggaaagg gcctggagtg gctgggagtg atatggagtg gtggaagcac agactataat      180

gcagctttca tatccagact gagcatcagc aaggacaact ccaagagcca agttttcttt      240

aaaatgaaca gtctgcaggc tgatgacaca gccatatact actgtgccag aaaaggaggg      300

atctactatg ctaaccatta ctatgctatg gactactggg gtcaaggaac ctcagtcacc      360

gtctcctca                                                              369


<210>  35
<211>  723
<212>  DNA
<213>  Mus musculus

<400>  35
atggaatcac agactcaggt cctcatctcc ttgctgttct gggtatctgg tacctgtggg       60

gacattgtga tgacacagtc tccatcctcc ctgagtgtgt cagcaggaga gaaggtcact      120

atgagctgca agtccagtca gagtctgtta aacagtggaa atcaaaagaa ctatatggcc      180

tggtatcagc agaaaccagg gcagcctcct aaactgttga tctacggggc atccactagg      240

gaatctgggg tccctgatcg cttcacaggc agtggatctg gaaccgattt cactcttacc      300

atcagcagtg tgcaggctga agacctggca gtttattact gtcagaatga tcatagttat      360

ccgctcacgt tcggtgctgg gaccaagctg gagctgaaac gggctgatgc tgcaccaact      420

gtatccatct tcccaccatc cagtgagcag ttaacatctg gaggtgcctc agtcgtgtgc      480

ttcttgaaca acttctaccc caaagacatc aatgtcaagt ggaagattga tggcagtgaa      540

cgacaaaatg gcgtcctgaa cagttggact gatcaggaca gcaaagacag cacctacagc      600

atgagcagca ccctcacgtt gaccaaggac gagtatgaac gacataacag ctatacctgt      660

gaggccactc acaagacatc aacttcaccc attgtcaaga gcttcaacag gaatgagtgt      720

tag                                                                    723


<210>  36
<211>  907
<212>  DNA
<213>  Mus musculus

<400>  36
atggaatcac agactcaggt cctcatctcc ttgctgttct gggtatctgg tacctgtggg       60

gacattgtga tgacacagtc tccatcctcc ctgagtgtgt cagcaggaga gaaggtcact      120

atgagctgca agtccagtca gagtctgtta aacagtggaa atcaaaagaa ctatatggcc      180

tggtatcagc agaaaccagg gcagcctcct aaactgttga tctacggggc atccactagg      240

gaatctgggg tccctgatcg cttcacaggc agtggatctg gaaccgattt cactcttacc      300

atcagcagtg tgcaggctga agacctggca gtttattact gtcagaatga tcatagttat      360

ccgctcacgt tcggtgctgg gaccaagctg gagctgaaac gggctgatgc tgcaccaact      420

gtatccatct tcccaccatc cagtgagcag ttaacatctg gaggtgcctc agtcgtgtgc      480

ttcttgaaca acttctaccc caaagacatc aatgtcaagt ggaagattga tggcagtgaa      540

cgacaaaatg gcgtcctgaa cagttggact gatcaggaca gcaaagacag cacctacagc      600

atgagcagca ccctcacgtt gaccaaggac gagtatgaac gacataacag ctatacctgt      660

gaggccactc acaagacatc aacttcaccc attgtcaaga gcttcaacag gaatgagtgt      720

tagagacaaa ggtcctgaga cgccaccacc agctccccag ctccatccta tcttcccttc      780

taaggtcttg gaggcttccc cacaagcgac ctaccactgt tgcggtgctc caaacctcct      840

ccccacctcc ttctcctcct cctccctttc cttggctttt atcatgctaa tatttgcatg      900

ataaaaa                                                                907


<210>  37
<211>  1401
<212>  DNA
<213>  Mus musculus

<400>  37
atggctgtct tggggctgct cttctgcctg gtgacattcc caagctgtgt cctctcccag       60

gtgcagctga agcagtcagg acctggccta gtgcagccct cacagagcct gtccatcacc      120

tgcacagtct ctggtttctc attaactaac tatggtttac actgggttcg ccagtctcca      180

ggaaagggcc tggagtggct gggagtgata tggagtggtg gaagcacaga ctataatgca      240

gctttcatat ccagactgag catcagcaag gacaactcca agagccaagt tttctttaaa      300

atgaacagtc tgcaggctga tgacacagcc atatactact gtgccagaaa aggagggatc      360

tactatgcta accattacta tgctatggac tactggggtc aaggaacctc agtcaccgtc      420

tcctcagcca aaacgacacc cccatctgtc tatccactgg cccctggatc tgctgcccaa      480

actaactcca tggtgaccct gggatgcctg gtcaagggct atttccctga gccagtgaca      540

gtgacctgga actctggatc cctgtccagc ggtgtgcaca ccttcccagc tgtcctggag      600

tctgacctct acactctgag cagctcagtg actgtcccct ccagccctcg gcccagcgag      660

accgtcacct gcaacgttgc ccacccggcc agcagcacca aggtggacaa gaaaattgtg      720

cccagggatt gtggttgtaa gccttgcata tgtacagtcc cagaagtatc atctgtcttc      780

atcttccccc caaagcccaa ggatgtgctc accattactc tgactcctaa ggtcacgtgt      840

gttgtggtag acatcagcaa ggatgatccc gaggtccagt tcagctggtt tgtagatgat      900

gtggaggtgc acacagctca gacgcaaccc cgggaggagc agttcaacag cactttccgc      960

tcagtcagtg aacttcccat catgcaccag gactggctca atggcaagga gttcaaatgc     1020

agggtcaaca gtgcagcttt ccctgccccc atcgagaaaa ccatctccaa aaccaaaggc     1080

agaccgaagg ctccacaggt gtacaccatt ccacctccca aggagcagat ggccaaggat     1140

aaagtcagtc tgacctgcat gataacagac ttcttccctg aagacattac tgtggagtgg     1200

cagtggaatg ggcagccagc ggagaactac aagaacactc agcccatcat gaacacgaat     1260

ggctcttact tcgtctacag caagctcaat gtgcagaaga gcaactggga ggcaggaaat     1320

actttcacct gctctgtgtt acatgagggc ctgcacaacc accatactga gaagagcctc     1380

tcccactctc ctggtaaatg a                                               1401


<210>  38
<211>  1563
<212>  DNA
<213>  Mus musculus

<400>  38
cctccatcag agcatggctg tcttggggct gctcttctgc ctggtgacat tcccaagctg       60

tgtcctctcc caggtgcagc tgaagcagtc aggacctggc ctagtgcagc cctcacagag      120

cctgtccatc acctgcacag tctctggttt ctcattaact aactatggtt tacactgggt      180

tcgccagtct ccaggaaagg gcctggagtg gctgggagtg atatggagtg gtggaagcac      240

agactataat gcagctttca tatccagact gagcatcagc aaggacaact ccaagagcca      300

agttttcttt aaaatgaaca gtctgcaggc tgatgacaca gccatatact actgtgccag      360

aaaaggaggg atctactatg ctaaccatta ctatgctatg gactactggg gtcaaggaac      420

ctcagtcacc gtctcctcag ccaaaacgac acccccatct gtctatccac tggcccctgg      480

atctgctgcc caaactaact ccatggtgac cctgggatgc ctggtcaagg gctatttccc      540

tgagccagtg acagtgacct ggaactctgg atccctgtcc agcggtgtgc acaccttccc      600

agctgtcctg gagtctgacc tctacactct gagcagctca gtgactgtcc cctccagccc      660

tcggcccagc gagaccgtca cctgcaacgt tgcccacccg gccagcagca ccaaggtgga      720

caagaaaatt gtgcccaggg attgtggttg taagccttgc atatgtacag tcccagaagt      780

atcatctgtc ttcatcttcc ccccaaagcc caaggatgtg ctcaccatta ctctgactcc      840

taaggtcacg tgtgttgtgg tagacatcag caaggatgat cccgaggtcc agttcagctg      900

gtttgtagat gatgtggagg tgcacacagc tcagacgcaa ccccgggagg agcagttcaa      960

cagcactttc cgctcagtca gtgaacttcc catcatgcac caggactggc tcaatggcaa     1020

ggagttcaaa tgcagggtca acagtgcagc tttccctgcc cccatcgaga aaaccatctc     1080

caaaaccaaa ggcagaccga aggctccaca ggtgtacacc attccacctc ccaaggagca     1140

gatggccaag gataaagtca gtctgacctg catgataaca gacttcttcc ctgaagacat     1200

tactgtggag tggcagtgga atgggcagcc agcggagaac tacaagaaca ctcagcccat     1260

catgaacacg aatggctctt acttcgtcta cagcaagctc aatgtgcaga agagcaactg     1320

ggaggcagga aatactttca cctgctctgt gttacatgag ggcctgcaca accaccatac     1380

tgagaagagc ctctcccact ctcctggtaa atgatcccag tgtccttgga gccctctggt     1440

cctacaggac tctgacacct acctccaccc ctccctgtat aaataaagca cccagcactg     1500

ccttgggacc ctgaaaaaaa aaagaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa     1560

aaa                                                                   1563


<210>  39
<211>  240
<212>  PRT
<213>  Artificial

<220>
<223>  BV10 chimeric kappa light chain

<400>  39

Met Val Phe Thr Pro Gln Ile Leu Gly Leu Met Leu Phe Trp Ile Ser 
1               5                   10                  15      


Gly Ala Arg Gly Asp Ile Val Met Thr Gln Ser Pro Ser Ser Leu Ser 
            20                  25                  30          


Val Ser Ala Gly Glu Lys Val Thr Met Ser Cys Lys Ser Ser Gln Ser 
        35                  40                  45              


Leu Leu Asn Ser Gly Asn Gln Lys Asn Tyr Met Ala Trp Tyr Gln Gln 
    50                  55                  60                  


Lys Pro Gly Gln Pro Pro Lys Leu Leu Ile Tyr Gly Ala Ser Thr Arg 
65                  70                  75                  80  


Glu Ser Gly Val Pro Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp 
                85                  90                  95      


Phe Thr Leu Thr Ile Ser Ser Val Gln Ala Glu Asp Leu Ala Val Tyr 
            100                 105                 110         


Tyr Cys Gln Asn Asp His Ser Tyr Pro Leu Thr Phe Gly Ala Gly Thr 
        115                 120                 125             


Lys Leu Glu Leu Lys Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe 
    130                 135                 140                 


Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys 
145                 150                 155                 160 


Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val 
                165                 170                 175     


Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln 
            180                 185                 190         


Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser 
        195                 200                 205             


Lys Ala Asp Tyr Glu Lys His Lys Val Tyr Ala Cys Glu Val Thr His 
    210                 215                 220                 


Gln Gly Leu Ser Ser Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
225                 230                 235                 240 


<210>  40
<211>  723
<212>  DNA
<213>  Artificial

<220>
<223>  BV10 chimeric kappa light chain CDS

<400>  40
atggttttca cacctcagat acttggactt atgctttttt ggatttcagg tgctcgagga       60

gacattgtga tgacacagtc tccatcctcc ctgagtgtgt cagcaggaga gaaggtcact      120

atgagctgca agtccagtca gagtctgtta aacagtggaa atcaaaagaa ctatatggcc      180

tggtatcagc agaaaccagg gcagcctcct aaactgttga tctacggggc atccactagg      240

gaatctgggg tccctgatcg cttcacaggc agtggatctg gaaccgattt cactcttacc      300

atcagcagtg tgcaggctga agacctggca gtttattact gtcagaatga tcatagttat      360

ccgctcacgt tcggtgctgg gaccaagctg gagctgaaac ggactgtggc tgcaccatct      420

gtcttcatct tcccgccatc tgatgagcag ttgaaatctg gaactgcctc tgttgtgtgc      480

ctgctgaata acttctatcc cagagaggcc aaagtacagt ggaaggtgga taacgccctc      540

caatcgggta actcccagga gagtgtcaca gagcaggaca gcaaggacag cacctacagc      600

ctcagcagca ccctgacgct gagcaaagca gactacgaga aacacaaagt ctacgcctgc      660

gaagtcaccc atcagggcct gagctcgccc gtcacaaaga gcttcaacag gggagagtgt      720

tag                                                                    723


<210>  41
<211>  472
<212>  PRT
<213>  Artificial

<220>
<223>  BV10 chimeric IgG gamma 1 heavy chain

<400>  41

Met Gly Trp Ser Trp Ile Phe Leu Phe Leu Leu Ser Gly Thr Ala Gly 
1               5                   10                  15      


Val Leu Ser Gln Val Gln Leu Lys Gln Ser Gly Pro Gly Leu Val Gln 
            20                  25                  30          


Pro Ser Gln Ser Leu Ser Ile Thr Cys Thr Val Ser Gly Phe Ser Leu 
        35                  40                  45              


Thr Asn Tyr Gly Leu His Trp Val Arg Gln Ser Pro Gly Lys Gly Leu 
    50                  55                  60                  


Glu Trp Leu Gly Val Ile Trp Ser Gly Gly Ser Thr Asp Tyr Asn Ala 
65                  70                  75                  80  


Ala Phe Ile Ser Arg Leu Ser Ile Ser Lys Asp Asn Ser Lys Ser Gln 
                85                  90                  95      


Val Phe Phe Lys Met Asn Ser Leu Gln Ala Asp Asp Thr Ala Ile Tyr 
            100                 105                 110         


Tyr Cys Ala Arg Lys Gly Gly Ile Tyr Tyr Ala Asn His Tyr Tyr Ala 
        115                 120                 125             


Met Asp Tyr Trp Gly Gln Gly Thr Ser Val Thr Val Ser Ser Ala Ser 
    130                 135                 140                 


Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr 
145                 150                 155                 160 


Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro 
                165                 170                 175     


Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val 
            180                 185                 190         


His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser 
        195                 200                 205             


Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile 
    210                 215                 220                 


Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val 
225                 230                 235                 240 


Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala 
                245                 250                 255     


Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 
            260                 265                 270         


Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 
        275                 280                 285             


Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val 
    290                 295                 300                 


Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 
305                 310                 315                 320 


Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln 
                325                 330                 335     


Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala 
            340                 345                 350         


Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro 
        355                 360                 365             


Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr 
    370                 375                 380                 


Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser 
385                 390                 395                 400 


Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 
                405                 410                 415     


Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr 
            420                 425                 430         


Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe 
        435                 440                 445             


Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys 
    450                 455                 460                 


Ser Leu Ser Leu Ser Pro Gly Lys 
465                 470         


<210>  42
<211>  1422
<212>  DNA
<213>  Artificial

<220>
<223>  BV10 chimeric IgG gamma 1 heavy chain CDS

<400>  42
atgggatgga gctggatctt tctctttctc ctgtcaggaa ctgcaggtgt cctctcccag       60

gtgcagctga agcagtcagg acctggccta gtgcagccct cacagagcct gtccatcacc      120

tgcacagtct ctggtttctc attaactaac tatggtttac actgggttcg ccagtctcca      180

ggaaagggcc tggagtggct gggagtgata tggagtggtg gaagcacaga ctataatgca      240

gctttcatat ccagactgag catcagcaag gacaactcca agagccaagt tttctttaaa      300

atgaacagtc tgcaggctga tgacacagcc atatactact gtgccagaaa aggagggatc      360

tactatgcta accattacta tgctatggac tactggggtc aaggaacctc agtcaccgtc      420

tcctcagcct ccaccaaggg cccatcggtc ttccccctgg caccctcctc caagagcacc      480

tctgggggca cagcggccct gggctgtctg gtcaaggact acttccccga accggtgacg      540

gtgtcgtgga actcaggcgc cctgaccagc ggcgtgcaca ccttcccggc tgtcctacag      600

tcctcaggac tctactccct cagcagcgtg gtgaccgtgc cctccagcag cttgggcacc      660

cagacctaca tctgcaacgt gaatcacaag cccagcaaca ccaaggtgga caagaaagtt      720

gagcccaaat cttgtgacaa aactcacaca tgcccaccgt gcccagcacc tgaactcctg      780

gggggcccgt cagtcttcct cttcccccca aaacccaagg acaccctcat gatctcccgg      840

acccctgagg tcacatgcgt ggtggtggac gtgagccacg aagaccctga ggtcaagttc      900

aactggtacg tggacggcgt ggaggtgcat aatgccaaga caaagccgcg ggaggagcag      960

tacaacagca cgtatcgtgt ggtcagcgtc ctcaccgtcc tgcaccagga ctggctgaat     1020

ggcaaggagt acaagtgcaa ggtctccaac aaagccctcc cagcccccat cgagaaaacc     1080

atctccaaag ccaaagggca gccccgagaa ccacaggtgt acaccctgcc cccatcccgg     1140

gatgagctga ccaagaacca ggtcagcctg acctgcctgg tcaaaggctt ctatcccagc     1200

gacatcgccg tggagtggga gagcaatggg cagccggaga acaactacaa gaccacgcct     1260

cccgtgctgg actccgacgg ctccttcttc ctctacagca agctcaccgt ggacaagagc     1320

aggtggcagc aggggaacgt cttctcatgc tccgtgatgc atgaggctct gcacaaccac     1380

tacacgcaga agagcctctc cctgtctccg ggtaaatgat aa                        1422


<210>  43
<211>  472
<212>  PRT
<213>  Artificial

<220>
<223>  SDIE BV10 heavy chain

<400>  43

Met Gly Trp Ser Trp Ile Phe Leu Phe Leu Leu Ser Gly Thr Ala Gly 
1               5                   10                  15      


Val Leu Ser Gln Val Gln Leu Lys Gln Ser Gly Pro Gly Leu Val Gln 
            20                  25                  30          


Pro Ser Gln Ser Leu Ser Ile Thr Cys Thr Val Ser Gly Phe Ser Leu 
        35                  40                  45              


Thr Asn Tyr Gly Leu His Trp Val Arg Gln Ser Pro Gly Lys Gly Leu 
    50                  55                  60                  


Glu Trp Leu Gly Val Ile Trp Ser Gly Gly Ser Thr Asp Tyr Asn Ala 
65                  70                  75                  80  


Ala Phe Ile Ser Arg Leu Ser Ile Ser Lys Asp Asn Ser Lys Ser Gln 
                85                  90                  95      


Val Phe Phe Lys Met Asn Ser Leu Gln Ala Asp Asp Thr Ala Ile Tyr 
            100                 105                 110         


Tyr Cys Ala Arg Lys Gly Gly Ile Tyr Tyr Ala Asn His Tyr Tyr Ala 
        115                 120                 125             


Met Asp Tyr Trp Gly Gln Gly Thr Ser Val Thr Val Ser Ser Ala Ser 
    130                 135                 140                 


Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr 
145                 150                 155                 160 


Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro 
                165                 170                 175     


Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val 
            180                 185                 190         


His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser 
        195                 200                 205             


Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile 
    210                 215                 220                 


Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val 
225                 230                 235                 240 


Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala 
                245                 250                 255     


Pro Glu Leu Leu Gly Gly Pro Asp Val Phe Leu Phe Pro Pro Lys Pro 
            260                 265                 270         


Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 
        275                 280                 285             


Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val 
    290                 295                 300                 


Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 
305                 310                 315                 320 


Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln 
                325                 330                 335     


Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala 
            340                 345                 350         


Leu Pro Ala Pro Glu Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro 
        355                 360                 365             


Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr 
    370                 375                 380                 


Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser 
385                 390                 395                 400 


Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 
                405                 410                 415     


Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr 
            420                 425                 430         


Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe 
        435                 440                 445             


Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys 
    450                 455                 460                 


Ser Leu Ser Leu Ser Pro Gly Lys 
465                 470         


<210>  44
<211>  1422
<212>  DNA
<213>  Artificial

<220>
<223>  SDIE BV10 heavy chain CDS

<400>  44
atgggatgga gctggatctt tctctttctc ctgtcaggaa ctgcaggtgt cctctcccag       60

gtgcagctga agcagtcagg acctggccta gtgcagccct cacagagcct gtccatcacc      120

tgcacagtct ctggtttctc attaactaac tatggtttac actgggttcg ccagtctcca      180

ggaaagggcc tggagtggct gggagtgata tggagtggtg gaagcacaga ctataatgca      240

gctttcatat ccagactgag catcagcaag gacaactcca agagccaagt tttctttaaa      300

atgaacagtc tgcaggctga tgacacagcc atatactact gtgccagaaa aggagggatc      360

tactatgcta accattacta tgctatggac tactggggtc aaggaacctc agtcaccgtc      420

tcctcagcct ccaccaaggg cccatcggtc ttccccctgg caccctcctc caagagcacc      480

tctgggggca cagcggccct gggctgtctg gtcaaggact acttccccga accggtgacg      540

gtgtcgtgga actcaggcgc cctgaccagc ggcgtgcaca ccttcccggc tgtcctacag      600

tcctcaggac tctactccct cagcagcgtg gtgaccgtgc cctccagcag cttgggcacc      660

cagacctaca tctgcaacgt gaatcacaag cccagcaaca ccaaggtgga caagaaagtt      720

gagcccaaat cttgtgacaa aactcacaca tgcccaccgt gcccagcacc tgaactcctg      780

gggggcccgg atgtcttcct cttcccccca aaacccaagg acaccctcat gatctcccgg      840

acccctgagg tcacatgcgt ggtggtggac gtgagccacg aagaccctga ggtcaagttc      900

aactggtacg tggacggcgt ggaggtgcat aatgccaaga caaagccgcg ggaggagcag      960

tacaacagca cgtatcgtgt ggtcagcgtc ctcaccgtcc tgcaccagga ctggctgaat     1020

ggcaaggagt acaagtgcaa ggtctccaac aaagccctcc cagcccccga ggagaaaacc     1080

atctccaaag ccaaagggca gccccgagaa ccacaggtgt acaccctgcc cccatcccgg     1140

gatgagctga ccaagaacca ggtcagcctg acctgcctgg tcaaaggctt ctatcccagc     1200

gacatcgccg tggagtggga gagcaatggg cagccggaga acaactacaa gaccacgcct     1260

cccgtgctgg actccgacgg ctccttcttc ctctacagca agctcaccgt ggacaagagc     1320

aggtggcagc aggggaacgt cttctcatgc tccgtgatgc atgaggctct gcacaaccac     1380

tacacgcaga agagcctctc cctgtctccg ggtaaatgat aa                        1422


<210>  45
<211>  25
<212>  DNA
<213>  Artificial

<220>
<223>  Oligonucleotide primer gamma1-for

<400>  45
caaggcttac aaccacaatc cctgg                                             25


<210>  46
<211>  29
<212>  DNA
<213>  Artificial

<220>
<223>  Oligonucleotide primer gamma1-back

<400>  46
catatgtaca gtcccagaag tatcatctg                                         29


<210>  47
<211>  31
<212>  DNA
<213>  Artificial

<220>
<223>  Oligonucleotide primer ck-for

<400>  47
tgttcaagaa gcacacgact gaggcacctc c                                      31


<210>  48
<211>  29
<212>  DNA
<213>  Artificial

<220>
<223>  Oligonucleotide primer ck-back

<400>  48
acttctaccc caaagacatc aatgtcaag                                         29


<210>  49
<211>  24
<212>  DNA
<213>  Artificial

<220>
<223>  Oligonucleotide primer k-for1

<400>  49
cctgttgaag ctcttgacaa tggg                                              24


<210>  50
<211>  24
<212>  DNA
<213>  Artificial

<220>
<223>  Oligonucleotide primer k-for2

<400>  50
atgtcttgtg agtggcctca cagg                                              24


<210>  51
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>  Oligonucleotide primer CG1-for1

<400>  51
cgtctacagc aagctcaatg tgc                                               23


<210>  52
<211>  21
<212>  DNA
<213>  Artificial

<220>
<223>  Oligonucleotide primer CG1-for2

<400>  52
ccatctgtct atccactggc c                                                 21


<210>  53
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>  Oligonucleotide primer CG1-rev1

<400>  53
ccaggtcact gtcactggct cag                                               23


<210>  54
<211>  21
<212>  DNA
<213>  Artificial

<220>
<223>  Oligonucleotide primer CG1-rev2

<400>  54
cctcatgtaa cacagagcag g                                                 21


<210>  55
<211>  53
<212>  DNA
<213>  Artificial

<220>
<223>  Oligonucleotide primer 4G8-H-for

<400>  55
tctcttcaca ggtgtcctct ctcaggtcca actgcagcag cctggggctg agc              53


<210>  56
<211>  52
<212>  DNA
<213>  Artificial

<220>
<223>  Oligonucleotide primer 4G8-H-rev

<400>  56
gagaaggtag gactcacctg aggagactgt gagagtggtg ccttggcccc ag               52


<210>  57
<211>  60
<212>  DNA
<213>  Artificial

<220>
<223>  Oligonucleotide primer BV10-H-for

<400>  57
agacgtccac tctgtctttc tcttcacagg tgtcctctcc caggtgcagc tgaagcagtc       60


<210>  58
<211>  49
<212>  DNA
<213>  Artificial

<220>
<223>  Oligonucleotide primer BV10-H-rev

<400>  58
gagaaggtag gactcacctg aggagacggt gactgaggtt ccttgaccc                   49


<210>  59
<211>  40
<212>  DNA
<213>  Artificial

<220>
<223>  Oligonucleotide primer universal for (AatII)

<400>  59
agacgtccac tctgtctttc tcttcacagg tgtcctctcc                             40


<210>  60
<211>  33
<212>  DNA
<213>  Artificial

<220>
<223>  Oligonucleotide primer universal rev (ClaI)

<400>  60
tatcgattta gaatgggaga aggtaggact cac                                    33


<210>  61
<211>  42
<212>  DNA
<213>  Artificial

<220>
<223>  Oligonucleotide primer 4G8-L-for (XhoI)

<400>  61
actcgaggag atattgtgct aactcagtct ccagccaccc tg                          42


<210>  62
<211>  41
<212>  DNA
<213>  Artificial

<220>
<223>  Oligonucleotide primer 4G8-L-rev (SpeI)

<400>  62
tactagtact tacgttttat ttccagcttg gtcccccctc c                           41


<210>  63
<211>  40
<212>  DNA
<213>  Artificial

<220>
<223>  Oligonucleotide primer BV10-L-for (XhoI)

<400>  63
actcgaggag acattgtgat gacacagtct ccatcctccc                             40


<210>  64
<211>  47
<212>  DNA
<213>  Artificial

<220>
<223>  Oligonucleotide primer BV10-L-rev (SpeI)

<400>  64
actagtactt acgtttcagc tccagcttgg tcccagcacc gaacgtg                     47


<210>  65
<211>  952
<212>  PRT
<213>  Homo sapiens

<400>  65

Met Pro Ala Leu Ala Arg Asp Gly Gly Gln Leu Pro Leu Leu Val Val 
1               5                   10                  15      


Phe Ser Ala Met Ile Phe Gly Thr Ile Thr Asn Gln Asp Leu Pro Val 
            20                  25                  30          


Ile Lys Cys Val Leu Ile Asn His Lys Asn Asn Asp Ser Ser Val Gly 
        35                  40                  45              


Lys Ser Ser Ser Tyr Pro Met Val Ser Glu Ser Pro Glu Asp Leu Gly 
    50                  55                  60                  


Cys Ala Leu Arg Pro Gln Asn Ser Gly Thr Val Tyr Glu Ala Ala Ala 
65                  70                  75                  80  


Val Glu Val Asp Val Ser Ala Ser Ile Thr Leu Gln Val Leu Val Asp 
                85                  90                  95      


Ala Pro Gly Asn Ile Ser Cys Leu Trp Val Phe Lys His Ser Ser Leu 
            100                 105                 110         


Asn Cys Gln Pro His Phe Asp Leu Gln Asn Arg Gly Val Val Ser Met 
        115                 120                 125             


Val Ile Leu Lys Met Thr Glu Thr Gln Ala Gly Glu Tyr Leu Leu Phe 
    130                 135                 140                 


Ile Gln Ser Glu Ala Thr Asn Tyr Thr Ile Leu Phe Thr Val Ser Ile 
145                 150                 155                 160 


Arg Asn Thr Leu Leu Tyr Thr Leu Arg Arg Pro Tyr Phe Arg Lys Met 
                165                 170                 175     


Glu Asn Gln Asp Ala Leu Val Cys Ile Ser Glu Ser Val Pro Glu Pro 
            180                 185                 190         


Ile Val Glu Trp Val Leu Cys Asp Ser Gln Gly Glu Ser Cys Lys Glu 
        195                 200                 205             


Glu Ser Pro Ala Val Val Lys Lys Glu Glu Lys Val Leu His Glu Leu 
    210                 215                 220                 


Phe Gly Met Asp Ile Arg Cys Cys Ala Arg Asn Glu Leu Gly Arg Glu 
225                 230                 235                 240 


Cys Thr Arg Leu Phe Thr Ile Asp Leu Asn Gln Thr Pro Gln Thr Thr 
                245                 250                 255     


Leu Pro Gln Leu Phe Leu Lys Val Gly Glu Pro Leu Trp Ile Arg Cys 
            260                 265                 270         


Lys Ala Val His Val Asn His Gly Phe Gly Leu Thr Trp Glu Leu Glu 
        275                 280                 285             


Asn Lys Ala Leu Glu Glu Gly Asn Tyr Phe Glu Met Ser Thr Tyr Ser 
    290                 295                 300                 


Thr Asn Arg Thr Met Ile Arg Ile Leu Phe Ala Phe Val Ser Ser Val 
305                 310                 315                 320 


Ala Arg Asn Asp Thr Gly Tyr Tyr Thr Cys Ser Ser Ser Lys His Pro 
                325                 330                 335     


Ser Gln Ser Ala Leu Val Thr Ile Val Glu Lys Gly Phe Ile Asn Ala 
            340                 345                 350         


Thr Asn Ser Ser Glu Asp Tyr Glu Ile Asp Gln Tyr Glu Glu Phe Cys 
        355                 360                 365             


Phe Ser Val Arg Phe Lys Ala Tyr Pro Gln Ile Arg Cys Thr Trp Thr 
    370                 375                 380                 


Phe Ser Arg Lys Ser Phe Pro Cys Glu Gln Lys Gly Leu Asp Asn Gly 
385                 390                 395                 400 


Tyr Ser Ile Ser Lys Phe Cys Asn His Lys His Gln Pro Gly Glu Tyr 
                405                 410                 415     


Ile Phe His Ala Glu Asn Asp Asp Ala Gln Phe Thr Lys Met Phe Thr 
            420                 425                 430         


Leu Asn Ile Arg Arg Lys Pro Gln Val Leu Ala Glu Ala Ser Ala Ser 
        435                 440                 445             


Gln Ala Ser Cys Phe Ser Asp Gly Tyr Pro Leu Pro Ser Trp Thr Trp 
    450                 455                 460                 


Lys Lys Cys Ser Asp Lys Ser Pro Asn Cys Thr Glu Glu Ile Thr Glu 
465                 470                 475                 480 


Gly Val Trp Asn Arg Lys Ala Asn Arg Lys Val Phe Gly Gln Trp Val 
                485                 490                 495     


Ser Ser Ser Thr Leu Asn Met Ser Glu Ala Ile Lys Gly Phe Leu Val 
            500                 505                 510         


Lys Cys Cys Ala Tyr Asn Ser Leu Gly Thr Ser Cys Glu Thr Ile Leu 
        515                 520                 525             


Leu Asn Ser Pro Gly Pro Phe Pro Phe Ile Gln Asp Asn Ile Ser Phe 
    530                 535                 540                 


Tyr Ala Thr Ile Gly Val Cys Leu Leu Phe Ile Val Val Leu Thr Leu 
545                 550                 555                 560 


Leu Ile Cys His Lys Tyr Lys Lys Gln Phe Arg Tyr Glu Ser Gln Leu 
                565                 570                 575     


Gln Met Val Gln Val Thr Gly Ser Ser Asp Asn Glu Tyr Phe Tyr Val 
            580                 585                 590         


Asp Phe Arg Glu Tyr Glu Tyr Asp Leu Lys Trp Glu Phe Pro Arg Glu 
        595                 600                 605             


Asn Leu Glu Phe Gly Lys Val Leu Gly Ser Gly Ala Phe Gly Lys Val 
    610                 615                 620                 


Met Asn Ala Thr Ala Tyr Gly Ile Ser Lys Thr Gly Val Ser Ile Gln 
625                 630                 635                 640 


Val Ala Val Lys Met Leu Lys Glu Lys Ala Asp Ser Ser Glu Arg Glu 
                645                 650                 655     


Ala Leu Met Ser Glu Leu Lys Met Met Thr Gln Leu Gly Ser His Glu 
            660                 665                 670         


Asn Ile Val Asn Leu Leu Gly Ala Cys Thr Leu Ser Gly Pro Ile Tyr 
        675                 680                 685             


Leu Ile Phe Glu Tyr Cys Cys Tyr Gly Asp Leu Leu Asn Tyr Leu Arg 
    690                 695                 700                 


Ser Lys Arg Glu Lys Phe His Arg Thr Trp Thr Glu Ile Phe Lys Glu 
705                 710                 715                 720 


His Asn Phe Ser Phe Tyr Pro Thr Phe Gln Ser His Pro Asn Ser Ser 
                725                 730                 735     


Met Pro Gly Ser Arg Glu Val Gln Ile His Pro Asp Ser Asp Gln Ile 
            740                 745                 750         


Ser Gly Leu His Gly Asn Ser Phe His Ser Glu Asp Glu Ile Glu Tyr 
        755                 760                 765             


Glu Asn Gln Lys Arg Leu Glu Glu Glu Glu Asp Leu Asn Val Leu Thr 
    770                 775                 780                 


Phe Glu Asp Leu Leu Cys Phe Ala Tyr Gln Val Ala Lys Gly Met Glu 
785                 790                 795                 800 


Phe Leu Glu Phe Lys Ser Ala Arg Leu Pro Val Lys Trp Met Ala Pro 
                805                 810                 815     


Glu Ser Leu Phe Glu Gly Ile Tyr Thr Ile Lys Ser Asp Val Trp Ser 
            820                 825                 830         


Tyr Gly Ile Leu Leu Trp Glu Ile Phe Ser Leu Gly Val Asn Pro Tyr 
        835                 840                 845             


Pro Gly Ile Pro Val Asp Ala Asn Phe Tyr Lys Leu Ile Gln Asn Gly 
    850                 855                 860                 


Phe Lys Met Asp Gln Pro Phe Tyr Ala Thr Glu Glu Ile Tyr Ile Ile 
865                 870                 875                 880 


Met Gln Ser Cys Trp Ala Phe Asp Ser Arg Lys Arg Pro Ser Phe Pro 
                885                 890                 895     


Asn Leu Thr Ser Phe Leu Gly Cys Gln Leu Ala Asp Ala Glu Glu Ala 
            900                 905                 910         


Met Tyr Gln Asn Val Asp Gly Arg Val Ser Glu Cys Pro His Thr Tyr 
        915                 920                 925             


Gln Asn Arg Arg Pro Phe Ser Arg Glu Met Asp Leu Gly Leu Leu Ser 
    930                 935                 940                 


Pro Gln Ala Gln Val Glu Asp Ser 
945                 950         


<210>  66
<211>  24
<212>  PRT
<213>  Artificial

<220>
<223>  M-Tag; amino acids #455-466 of the human Ig alpha 1 tailpiece and
       c-myc epitope

<400>  66

Pro Thr His Val Asn Val Ser Val Val Met Ala Glu Glu Gln Lys Leu 
1               5                   10                  15      


Ile Ser Glu Glu Asp Leu Leu Arg 
            20                  


<210>  67
<211>  12
<212>  PRT
<213>  Artificial

<220>
<223>  amino acids 455-466 of the human Ig alpha 1 tailpiece

<400>  67

Pro Thr His Val Asn Val Ser Val Val Met Ala Glu 
1               5                   10          


<210>  68
<211>  12
<212>  PRT
<213>  artificial

<220>
<223>  c-myc epitope

<400>  68

Glu Gln Lys Leu Ile Ser Glu Glu Asp Leu Leu Arg 
1               5                   10          


