                         SEQUENCE LISTING

<110>  The Univeristy of North Carolina at Chapel Hill
       Rathmell, W. Kimryn
       Bhanot, Gyan
       Brannon, A. Rose
       Reddy, Anupama
 
<120>  METHODS AND COMPOSITIONS FOR ANALYSIS OF CLEAR CELL RENAL CELL 
       CARCINOMA (ccRCC)

<130>  421/262 PCT

<150>  US 61/287,986
<151>  2009-12-18

<160>  20    

<170>  PatentIn version 3.5

<210>  1
<211>  6499
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (286)..(2349)

<400>  1
atcgaggtcc gcgggaggct cggagcgcgc caggcggaca ctcctctcgg ctcctccccg       60

gcagcggcgg cggctcggag cgggctccgg ggctcgggtg cagcggccag cgggcgcctg      120

gcggcgagga ttacccgggg aagtggttgt ctcctggctg gagccgcgag acgggcgctc      180

agggcgcggg gccggcggcg gcgaacgaga ggacggactc tggcggccgg gtcgttggcc      240

gcggggagcg cgggcaccgg gcgagcaggc cgcgtcgcgc tcacc atg gtc agc tac      297
                                                  Met Val Ser Tyr         
                                                  1                       

tgg gac acc ggg gtc ctg ctg tgc gcg ctg ctc agc tgt ctg ctt ctc        345
Trp Asp Thr Gly Val Leu Leu Cys Ala Leu Leu Ser Cys Leu Leu Leu           
5                   10                  15                  20            

aca gga tct agt tca ggt tca aaa tta aaa gat cct gaa ctg agt tta        393
Thr Gly Ser Ser Ser Gly Ser Lys Leu Lys Asp Pro Glu Leu Ser Leu           
                25                  30                  35                

aaa ggc acc cag cac atc atg caa gca ggc cag aca ctg cat ctc caa        441
Lys Gly Thr Gln His Ile Met Gln Ala Gly Gln Thr Leu His Leu Gln           
            40                  45                  50                    

tgc agg ggg gaa gca gcc cat aaa tgg tct ttg cct gaa atg gtg agt        489
Cys Arg Gly Glu Ala Ala His Lys Trp Ser Leu Pro Glu Met Val Ser           
        55                  60                  65                        

aag gaa agc gaa agg ctg agc ata act aaa tct gcc tgt gga aga aat        537
Lys Glu Ser Glu Arg Leu Ser Ile Thr Lys Ser Ala Cys Gly Arg Asn           
    70                  75                  80                            

ggc aaa caa ttc tgc agt act tta acc ttg aac aca gct caa gca aac        585
Gly Lys Gln Phe Cys Ser Thr Leu Thr Leu Asn Thr Ala Gln Ala Asn           
85                  90                  95                  100           

cac act ggc ttc tac agc tgc aaa tat cta gct gta cct act tca aag        633
His Thr Gly Phe Tyr Ser Cys Lys Tyr Leu Ala Val Pro Thr Ser Lys           
                105                 110                 115               

aag aag gaa aca gaa tct gca atc tat ata ttt att agt gat aca ggt        681
Lys Lys Glu Thr Glu Ser Ala Ile Tyr Ile Phe Ile Ser Asp Thr Gly           
            120                 125                 130                   

aga cct ttc gta gag atg tac agt gaa atc ccc gaa att ata cac atg        729
Arg Pro Phe Val Glu Met Tyr Ser Glu Ile Pro Glu Ile Ile His Met           
        135                 140                 145                       

act gaa gga agg gag ctc gtc att ccc tgc cgg gtt acg tca cct aac        777
Thr Glu Gly Arg Glu Leu Val Ile Pro Cys Arg Val Thr Ser Pro Asn           
    150                 155                 160                           

atc act gtt act tta aaa aag ttt cca ctt gac act ttg atc cct gat        825
Ile Thr Val Thr Leu Lys Lys Phe Pro Leu Asp Thr Leu Ile Pro Asp           
165                 170                 175                 180           

gga aaa cgc ata atc tgg gac agt aga aag ggc ttc atc ata tca aat        873
Gly Lys Arg Ile Ile Trp Asp Ser Arg Lys Gly Phe Ile Ile Ser Asn           
                185                 190                 195               

gca acg tac aaa gaa ata ggg ctt ctg acc tgt gaa gca aca gtc aat        921
Ala Thr Tyr Lys Glu Ile Gly Leu Leu Thr Cys Glu Ala Thr Val Asn           
            200                 205                 210                   

ggg cat ttg tat aag aca aac tat ctc aca cat cga caa acc aat aca        969
Gly His Leu Tyr Lys Thr Asn Tyr Leu Thr His Arg Gln Thr Asn Thr           
        215                 220                 225                       

atc ata gat gtc caa ata agc aca cca cgc cca gtc aaa tta ctt aga       1017
Ile Ile Asp Val Gln Ile Ser Thr Pro Arg Pro Val Lys Leu Leu Arg           
    230                 235                 240                           

ggc cat act ctt gtc ctc aat tgt act gct acc act ccc ttg aac acg       1065
Gly His Thr Leu Val Leu Asn Cys Thr Ala Thr Thr Pro Leu Asn Thr           
245                 250                 255                 260           

aga gtt caa atg acc tgg agt tac cct gat gaa aaa aat aag aga gct       1113
Arg Val Gln Met Thr Trp Ser Tyr Pro Asp Glu Lys Asn Lys Arg Ala           
                265                 270                 275               

tcc gta agg cga cga att gac caa agc aat tcc cat gcc aac ata ttc       1161
Ser Val Arg Arg Arg Ile Asp Gln Ser Asn Ser His Ala Asn Ile Phe           
            280                 285                 290                   

tac agt gtt ctt act att gac aaa atg cag aac aaa gac aaa gga ctt       1209
Tyr Ser Val Leu Thr Ile Asp Lys Met Gln Asn Lys Asp Lys Gly Leu           
        295                 300                 305                       

tat act tgt cgt gta agg agt gga cca tca ttc aaa tct gtt aac acc       1257
Tyr Thr Cys Arg Val Arg Ser Gly Pro Ser Phe Lys Ser Val Asn Thr           
    310                 315                 320                           

tca gtg cat ata tat gat aaa gca ttc atc act gtg aaa cat cga aaa       1305
Ser Val His Ile Tyr Asp Lys Ala Phe Ile Thr Val Lys His Arg Lys           
325                 330                 335                 340           

cag cag gtg ctt gaa acc gta gct ggc aag cgg tct tac cgg ctc tct       1353
Gln Gln Val Leu Glu Thr Val Ala Gly Lys Arg Ser Tyr Arg Leu Ser           
                345                 350                 355               

atg aaa gtg aag gca ttt ccc tcg ccg gaa gtt gta tgg tta aaa gat       1401
Met Lys Val Lys Ala Phe Pro Ser Pro Glu Val Val Trp Leu Lys Asp           
            360                 365                 370                   

ggg tta cct gcg act gag aaa tct gct cgc tat ttg act cgt ggc tac       1449
Gly Leu Pro Ala Thr Glu Lys Ser Ala Arg Tyr Leu Thr Arg Gly Tyr           
        375                 380                 385                       

tcg tta att atc aag gac gta act gaa gag gat gca ggg aat tat aca       1497
Ser Leu Ile Ile Lys Asp Val Thr Glu Glu Asp Ala Gly Asn Tyr Thr           
    390                 395                 400                           

atc ttg ctg agc ata aaa cag tca aat gtg ttt aaa aac ctc act gcc       1545
Ile Leu Leu Ser Ile Lys Gln Ser Asn Val Phe Lys Asn Leu Thr Ala           
405                 410                 415                 420           

act cta att gtc aat gtg aaa ccc cag att tac gaa aag gcc gtg tca       1593
Thr Leu Ile Val Asn Val Lys Pro Gln Ile Tyr Glu Lys Ala Val Ser           
                425                 430                 435               

tcg ttt cca gac ccg gct ctc tac cca ctg ggc agc aga caa atc ctg       1641
Ser Phe Pro Asp Pro Ala Leu Tyr Pro Leu Gly Ser Arg Gln Ile Leu           
            440                 445                 450                   

act tgt acc gca tat ggt atc cct caa cct aca atc aag tgg ttc tgg       1689
Thr Cys Thr Ala Tyr Gly Ile Pro Gln Pro Thr Ile Lys Trp Phe Trp           
        455                 460                 465                       

cac ccc tgt aac cat aat cat tcc gaa gca agg tgt gac ttt tgt tcc       1737
His Pro Cys Asn His Asn His Ser Glu Ala Arg Cys Asp Phe Cys Ser           
    470                 475                 480                           

aat aat gaa gag tcc ttt atc ctg gat gct gac agc aac atg gga aac       1785
Asn Asn Glu Glu Ser Phe Ile Leu Asp Ala Asp Ser Asn Met Gly Asn           
485                 490                 495                 500           

aga att gag agc atc act cag cgc atg gca ata ata gaa gga aag aat       1833
Arg Ile Glu Ser Ile Thr Gln Arg Met Ala Ile Ile Glu Gly Lys Asn           
                505                 510                 515               

aag atg gct agc acc ttg gtt gtg gct gac tct aga att tct gga atc       1881
Lys Met Ala Ser Thr Leu Val Val Ala Asp Ser Arg Ile Ser Gly Ile           
            520                 525                 530                   

tac att tgc ata gct tcc aat aaa gtt ggg act gtg gga aga aac ata       1929
Tyr Ile Cys Ile Ala Ser Asn Lys Val Gly Thr Val Gly Arg Asn Ile           
        535                 540                 545                       

agc ttt tat atc aca gat gtg cca aat ggg ttt cat gtt aac ttg gaa       1977
Ser Phe Tyr Ile Thr Asp Val Pro Asn Gly Phe His Val Asn Leu Glu           
    550                 555                 560                           

aaa atg ccg acg gaa gga gag gac ctg aaa ctg tct tgc aca gtt aac       2025
Lys Met Pro Thr Glu Gly Glu Asp Leu Lys Leu Ser Cys Thr Val Asn           
565                 570                 575                 580           

aag ttc tta tac aga gac gtt act tgg att tta ctg cgg aca gtt aat       2073
Lys Phe Leu Tyr Arg Asp Val Thr Trp Ile Leu Leu Arg Thr Val Asn           
                585                 590                 595               

aac aga aca atg cac tac agt att agc aag caa aaa atg gcc atc act       2121
Asn Arg Thr Met His Tyr Ser Ile Ser Lys Gln Lys Met Ala Ile Thr           
            600                 605                 610                   

aag gag cac tcc atc act ctt aat ctt acc atc atg aat gtt tcc ctg       2169
Lys Glu His Ser Ile Thr Leu Asn Leu Thr Ile Met Asn Val Ser Leu           
        615                 620                 625                       

caa gat tca ggc acc tat gcc tgc aga gcc agg aat gta tac aca ggg       2217
Gln Asp Ser Gly Thr Tyr Ala Cys Arg Ala Arg Asn Val Tyr Thr Gly           
    630                 635                 640                           

gaa gaa atc ctc cag aag aaa gaa att aca atc aga ggt gag cac tgc       2265
Glu Glu Ile Leu Gln Lys Lys Glu Ile Thr Ile Arg Gly Glu His Cys           
645                 650                 655                 660           

aac aaa aag gct gtt ttc tct cgg atc tcc aaa ttt aaa agc aca agg       2313
Asn Lys Lys Ala Val Phe Ser Arg Ile Ser Lys Phe Lys Ser Thr Arg           
                665                 670                 675               

aat gat tgt acc aca caa agt aat gta aaa cat taa aggactcatt            2359
Asn Asp Cys Thr Thr Gln Ser Asn Val Lys His                               
            680                 685                                       

aaaaagtaac agttgtctca tatcatcttg atttattgtc actgttgcta actttcaggc     2419

tcggaggaga tgctcctccc aaaatgagtt cggagatgat agcagtaata atgagacccc     2479

cgggccccag ctctgggccc cccattcagg ccgagggggc tgctccgggg ggccgacttg     2539

gtgcacgttt ggatttggag gatccctgca ctgccttctc tgtgtttgtt gctcttgctg     2599

ttttctcctg cctgataaac aacaacttgg gatgatcctt tccttccatt ttgatgccaa     2659

cctcttttta tttttaagtg ttgaagctgc acaaactgaa taatttaaac aaatgctggt     2719

ttctgccaaa gatggacacg aataagttaa ttttccagct cagaatgagt acagttgaat     2779

ttgagactct gtcggacttc tgcctggttt tatttgggac tatttcatct gctcttgatt     2839

tgtaaatagc acctggatag caagttataa tgcttattta tttgaaaatg cttttttttt     2899

ttttacgtta agcacattta tcttgaactg gagcttctaa aatgggcccc aggggtgcaa     2959

gatgttggtg taattcagag atagtaaagg tttatcgcag tgtgaattat aagagtccat     3019

ccaaatcaac gtcccctccc tcctctcatg cgatccaggt aattatgcag ttagtgccac     3079

agtagactag cctagcaaag ggtttgctcc ttgctgtctc tgactgcacc acacagctat     3139

tgatggcagc tgaaagaaag tggatcatgc cttaatttta aatattcctg tcctctggtt     3199

attattttaa ggaacttcat catgttaaaa tgacagcatt caaaggtgta ccacaatcaa     3259

tttatcaagg aaataaaggc tattgtaacc agagatttaa tgcattcttc taaatgtaaa     3319

tttaaaattt gccctttaaa aaagtccact ttccccatat gcaaatgtta ataggatttt     3379

tatggggatt aagaagcggc aaaactacag aagcagaatt caaagtaatt taaaaaatac     3439

acaccagttt taaatcaaga gaagttgtaa tctcttgttt taagcttgcg tttgagggaa     3499

aatgactttt tcaccaattt aatatgcatt gttctgttgt ttttatttat gattgatcat     3559

tatatgtgac ttgcataaac tatttaaaaa aaaaaactat aatgaccaaa atagccatgg     3619

ctgagaaaca cagtggctgg gcagttcaat aggaggtgac aatatgacaa cttctcaagc     3679

ttgggaactc accagactgt ttcctccttt aggtaacaga ttctgtccca cggctaaact     3739

tgtctttcac gtgggaattg cttttgtcaa acgtgaaaga gtaaacaata gcatttcccc     3799

agaatgccag ttttatggag ccccaaatgc tctgaaaaca attagtaacc tggaagttgt     3859

cagcccaaag gaaagaaaaa tcaattgtat cttgaaattt tacctatggc tctttggcct     3919

ggcttctttg ttcattataa gttagtgtgt tccttcagga aacaatgcct taataccata     3979

gaacatgggg gccttaatag ttgctaacat taaaaaagca aacagaatga ttgagggatc     4039

cttatgaaaa caaaatggtg aattggacat gcagaaccta ccatttcctt cccctgtttg     4099

caatttttgt ggggagggga ggatgttagt atttacaaaa gatgatttta agaacttcca     4159

agagatgagt ttaagaattc catagagtat tagttgttca ctgtgtaatt aatccttccg     4219

gagagtcttt tttttttttt ttaaagaaac ttttgggtgg gttttgtttt ttattagtta     4279

ccctaggggt atgttaccct ggggtatgaa gggaggtgaa gataacggag gggggagaaa     4339

aaaaaaagga gaaaaaagga gcctaaaatg gggaataatt gaaatggaac agggggtgtg     4399

aggctggttc ctcagtcccc attccaaacg gaggatagaa gctgtgtatt tatgtgacct     4459

ggcagatctc tggggccata acactgaaaa gtgaaagaac ctggtgggca gctatctttg     4519

gctactgata accagcagaa atgtctgtta attctgattt tctcaatttg aagggatcag     4579

ctacactgtt aaattttgga aagccactac ctacttccat caagtaactt aggtttcgaa     4639

atatgggttc aacgcacctc ccttattcaa aatgtcaaaa tagattatta taatgtataa     4699

agtaagaatt gacaaaatat gattcttggg ttgattggtc atttagaaac tagccaaaag     4759

tgagactttt aatgtagaac atttttcaga aatgggtaca aagaaaaatg catattactg     4819

tatatttcag agtgtttatg tgaaccttgt atttaattga gagtcccatg tacgttctgc     4879

agcctttttg ctgcttctat catctgaagt ttgtgtagta caaataaggc ctttgggatt     4939

cttaatgaca tttatgttaa aatgttctct tctctttaaa caccgttttc caatccacct     4999

gtcagggagt ccaaatcgtg tctgtgttga tgatgctata ctttgtagct agaaaaacaa     5059

ttttagtgtt gtgggctctg tattcagact tcctttttac aagaccgatg ggcagtgata     5119

gattatttta tcatatttaa tgcatgggaa atagtgtgct gaggaagcta ttaaaagtat     5179

aactcagtga attgggtctg agttttaaat gagatatttc aaaattggct tgccactgta     5239

aaagcgacta aataataata tgatactgtt ctttatgatc ttgtcatgtt tcactgatat     5299

gtttggggtc ttcactatgt aaaaaatgtc aaaattgtaa tgagcaagca tgtacaagta     5359

gtcgtaaatc aaaggtttta aacaggactg cattttcaat taggaaaagc tgtttggcag     5419

atagcatcca atgcaaaaac agaaatatcg taacgttctg cttagtgggc aagataagat     5479

aggaaagaca tgctcaaaga ggcaaaagaa tcattgctat cattcattct acactagttt     5539

gaagaagttt ttgtacatca gagcacttcc ttcagcacac ttttttgcct tcagatttca     5599

ttttttataa aatgagaaga ctaatgataa actgtagaaa tcaaaattta ttgagaaatc     5659

tgtttctcct aacagatagt aaccctgcca tgatatacta cttcaacaat gttataaaat     5719

ttatgtgata atatacattt taacctggga tttctaaatt gctttaacaa atgctaatcc     5779

tgagagttgc cctgcaggac tcaaaaggga aaggttttgg gacgtggcag aaccctgcag     5839

ggacatggaa ttaaggccat tgcaatgtat catctttgta gcattgtcat cactcctaag     5899

ctgccttcac agttttagta cactaagatg aggaaatcga aaatgggcag agaaagctca     5959

tactgtataa ttgaagacag tgacagagaa cgtgtcagtt atgccaaaac tcttttgatt     6019

tctgttccag gatttccaac aagaggggaa aggaatgact tgggagggtg ggaaagacat     6079

taggagttgt ttttattttt taccttggaa gctttagcta ccaatccagt accctcctaa     6139

ctagaatgta tacacatcag caggactgac tgactacttc attagagata tactgtactc     6199

attgggggcc ttgggggtac tgctgttctt atgtgggatt ttaatgttgt aatgtattgc     6259

atcttaatgt attgaattca ttttgttgta ctatattggt tggcatttta ttaaaataaa     6319

ttgtattgta tcatatttgt atgttttaag agaaaataat ataaaataca atatttgtac     6379

tattatatag tgcaaaaact acaaatctgt gcctctgcct cttgaattaa ttctttggtt     6439

gcttgcattt gggaagggaa tggagaaagg aaagaaccaa taaagctttc aaagttcaag     6499


<210>  2
<211>  687
<212>  PRT
<213>  Homo sapiens

<400>  2

Met Val Ser Tyr Trp Asp Thr Gly Val Leu Leu Cys Ala Leu Leu Ser 
1               5                   10                  15      


Cys Leu Leu Leu Thr Gly Ser Ser Ser Gly Ser Lys Leu Lys Asp Pro 
            20                  25                  30          


Glu Leu Ser Leu Lys Gly Thr Gln His Ile Met Gln Ala Gly Gln Thr 
        35                  40                  45              


Leu His Leu Gln Cys Arg Gly Glu Ala Ala His Lys Trp Ser Leu Pro 
    50                  55                  60                  


Glu Met Val Ser Lys Glu Ser Glu Arg Leu Ser Ile Thr Lys Ser Ala 
65                  70                  75                  80  


Cys Gly Arg Asn Gly Lys Gln Phe Cys Ser Thr Leu Thr Leu Asn Thr 
                85                  90                  95      


Ala Gln Ala Asn His Thr Gly Phe Tyr Ser Cys Lys Tyr Leu Ala Val 
            100                 105                 110         


Pro Thr Ser Lys Lys Lys Glu Thr Glu Ser Ala Ile Tyr Ile Phe Ile 
        115                 120                 125             


Ser Asp Thr Gly Arg Pro Phe Val Glu Met Tyr Ser Glu Ile Pro Glu 
    130                 135                 140                 


Ile Ile His Met Thr Glu Gly Arg Glu Leu Val Ile Pro Cys Arg Val 
145                 150                 155                 160 


Thr Ser Pro Asn Ile Thr Val Thr Leu Lys Lys Phe Pro Leu Asp Thr 
                165                 170                 175     


Leu Ile Pro Asp Gly Lys Arg Ile Ile Trp Asp Ser Arg Lys Gly Phe 
            180                 185                 190         


Ile Ile Ser Asn Ala Thr Tyr Lys Glu Ile Gly Leu Leu Thr Cys Glu 
        195                 200                 205             


Ala Thr Val Asn Gly His Leu Tyr Lys Thr Asn Tyr Leu Thr His Arg 
    210                 215                 220                 


Gln Thr Asn Thr Ile Ile Asp Val Gln Ile Ser Thr Pro Arg Pro Val 
225                 230                 235                 240 


Lys Leu Leu Arg Gly His Thr Leu Val Leu Asn Cys Thr Ala Thr Thr 
                245                 250                 255     


Pro Leu Asn Thr Arg Val Gln Met Thr Trp Ser Tyr Pro Asp Glu Lys 
            260                 265                 270         


Asn Lys Arg Ala Ser Val Arg Arg Arg Ile Asp Gln Ser Asn Ser His 
        275                 280                 285             


Ala Asn Ile Phe Tyr Ser Val Leu Thr Ile Asp Lys Met Gln Asn Lys 
    290                 295                 300                 


Asp Lys Gly Leu Tyr Thr Cys Arg Val Arg Ser Gly Pro Ser Phe Lys 
305                 310                 315                 320 


Ser Val Asn Thr Ser Val His Ile Tyr Asp Lys Ala Phe Ile Thr Val 
                325                 330                 335     


Lys His Arg Lys Gln Gln Val Leu Glu Thr Val Ala Gly Lys Arg Ser 
            340                 345                 350         


Tyr Arg Leu Ser Met Lys Val Lys Ala Phe Pro Ser Pro Glu Val Val 
        355                 360                 365             


Trp Leu Lys Asp Gly Leu Pro Ala Thr Glu Lys Ser Ala Arg Tyr Leu 
    370                 375                 380                 


Thr Arg Gly Tyr Ser Leu Ile Ile Lys Asp Val Thr Glu Glu Asp Ala 
385                 390                 395                 400 


Gly Asn Tyr Thr Ile Leu Leu Ser Ile Lys Gln Ser Asn Val Phe Lys 
                405                 410                 415     


Asn Leu Thr Ala Thr Leu Ile Val Asn Val Lys Pro Gln Ile Tyr Glu 
            420                 425                 430         


Lys Ala Val Ser Ser Phe Pro Asp Pro Ala Leu Tyr Pro Leu Gly Ser 
        435                 440                 445             


Arg Gln Ile Leu Thr Cys Thr Ala Tyr Gly Ile Pro Gln Pro Thr Ile 
    450                 455                 460                 


Lys Trp Phe Trp His Pro Cys Asn His Asn His Ser Glu Ala Arg Cys 
465                 470                 475                 480 


Asp Phe Cys Ser Asn Asn Glu Glu Ser Phe Ile Leu Asp Ala Asp Ser 
                485                 490                 495     


Asn Met Gly Asn Arg Ile Glu Ser Ile Thr Gln Arg Met Ala Ile Ile 
            500                 505                 510         


Glu Gly Lys Asn Lys Met Ala Ser Thr Leu Val Val Ala Asp Ser Arg 
        515                 520                 525             


Ile Ser Gly Ile Tyr Ile Cys Ile Ala Ser Asn Lys Val Gly Thr Val 
    530                 535                 540                 


Gly Arg Asn Ile Ser Phe Tyr Ile Thr Asp Val Pro Asn Gly Phe His 
545                 550                 555                 560 


Val Asn Leu Glu Lys Met Pro Thr Glu Gly Glu Asp Leu Lys Leu Ser 
                565                 570                 575     


Cys Thr Val Asn Lys Phe Leu Tyr Arg Asp Val Thr Trp Ile Leu Leu 
            580                 585                 590         


Arg Thr Val Asn Asn Arg Thr Met His Tyr Ser Ile Ser Lys Gln Lys 
        595                 600                 605             


Met Ala Ile Thr Lys Glu His Ser Ile Thr Leu Asn Leu Thr Ile Met 
    610                 615                 620                 


Asn Val Ser Leu Gln Asp Ser Gly Thr Tyr Ala Cys Arg Ala Arg Asn 
625                 630                 635                 640 


Val Tyr Thr Gly Glu Glu Ile Leu Gln Lys Lys Glu Ile Thr Ile Arg 
                645                 650                 655     


Gly Glu His Cys Asn Lys Lys Ala Val Phe Ser Arg Ile Ser Lys Phe 
            660                 665                 670         


Lys Ser Thr Arg Asn Asp Cys Thr Thr Gln Ser Asn Val Lys His 
        675                 680                 685         


<210>  3
<211>  4350
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (414)..(2357)

<400>  3
agttgaggga ttgacacaaa tggtcaggcg gcggcggcgg agaaggaggc ggaggcgcag       60

gggggagccg agcccgctgg gctgcggaga gttgcgctct ctacggggcc gcggccacta      120

gcgcggcgcc gccagccggg agccagcgag ccgagggcca ggaaggcggg acacgacccc      180

ggcgcgccct agccacccgg gttctccccg ccgcccgcgc ttcatgaatc gcaagtttcc      240

gcggcggcgg cggctgcggt acgcagaaca ggagccgggg gagcgggccg aaagcggctt      300

gggctcgacg gagggcaccc gcgcagaggt ctccctggcc gcagggggag ccgccgccgg      360

ccgtgcccct ggcagcccca gcggagcggc gccaagagag gagccgagaa agt atg         416
                                                           Met            
                                                           1              

gct gag gag gag gcg cct aag aag tcc cgg gcc gcc ggc ggt ggc gcg        464
Ala Glu Glu Glu Ala Pro Lys Lys Ser Arg Ala Ala Gly Gly Gly Ala           
            5                   10                  15                    

agc tgg gaa ctt tgt gcc ggg gcg ctc tcg gcc cgg ctg gcg gag gag        512
Ser Trp Glu Leu Cys Ala Gly Ala Leu Ser Ala Arg Leu Ala Glu Glu           
        20                  25                  30                        

ggc agc ggg gac gcc ggt ggc cgc cgc cgc ccg cca gtt gac ccc cgg        560
Gly Ser Gly Asp Ala Gly Gly Arg Arg Arg Pro Pro Val Asp Pro Arg           
    35                  40                  45                            

cga ttg gcg cgc cag ctg ctg ctg ctg ctt tgg ctg ctg gag gct ccg        608
Arg Leu Ala Arg Gln Leu Leu Leu Leu Leu Trp Leu Leu Glu Ala Pro           
50                  55                  60                  65            

ctg ctg ctg ggg gtc cgg gcc cag gcg gcg ggc cag ggg cca ggc cag        656
Leu Leu Leu Gly Val Arg Ala Gln Ala Ala Gly Gln Gly Pro Gly Gln           
                70                  75                  80                

ggg ccc ggg ccg ggg cag caa ccg ccg ccg ccg cct cag cag caa cag        704
Gly Pro Gly Pro Gly Gln Gln Pro Pro Pro Pro Pro Gln Gln Gln Gln           
            85                  90                  95                    

agc ggg cag cag tac aac ggc gag cgg ggc atc tcc gtc ccg gac cac        752
Ser Gly Gln Gln Tyr Asn Gly Glu Arg Gly Ile Ser Val Pro Asp His           
        100                 105                 110                       

ggc tat tgc cag ccc atc tcc atc ccg ctg tgc acg gac atc gcg tac        800
Gly Tyr Cys Gln Pro Ile Ser Ile Pro Leu Cys Thr Asp Ile Ala Tyr           
    115                 120                 125                           

aac cag acc atc atg ccc aac ctg ctg ggc cac acg aac cag gag gac        848
Asn Gln Thr Ile Met Pro Asn Leu Leu Gly His Thr Asn Gln Glu Asp           
130                 135                 140                 145           

gcg ggc ctg gag gtg cac cag ttc tac cct cta gtg aaa gtg cag tgt        896
Ala Gly Leu Glu Val His Gln Phe Tyr Pro Leu Val Lys Val Gln Cys           
                150                 155                 160               

tcc gct gag ctc aag ttc ttc ctg tgc tcc atg tac gcg ccc gtg tgc        944
Ser Ala Glu Leu Lys Phe Phe Leu Cys Ser Met Tyr Ala Pro Val Cys           
            165                 170                 175                   

acc gtg cta gag cag gcg ctg ccg ccc tgc cgc tcc ctg tgc gag cgc        992
Thr Val Leu Glu Gln Ala Leu Pro Pro Cys Arg Ser Leu Cys Glu Arg           
        180                 185                 190                       

gcg cgc cag ggc tgc gag gcg ctc atg aac aag ttc ggc ttc cag tgg       1040
Ala Arg Gln Gly Cys Glu Ala Leu Met Asn Lys Phe Gly Phe Gln Trp           
    195                 200                 205                           

cca gac acg ctc aag tgt gag aag ttc ccg gtg cac ggc gcc ggc gag       1088
Pro Asp Thr Leu Lys Cys Glu Lys Phe Pro Val His Gly Ala Gly Glu           
210                 215                 220                 225           

ctg tgc gtg ggc cag aac acg tcc gac aag ggc acc ccg acg ccc tcg       1136
Leu Cys Val Gly Gln Asn Thr Ser Asp Lys Gly Thr Pro Thr Pro Ser           
                230                 235                 240               

ctg ctt cca gag ttc tgg acc agc aac cct cag cac ggc ggc gga ggg       1184
Leu Leu Pro Glu Phe Trp Thr Ser Asn Pro Gln His Gly Gly Gly Gly           
            245                 250                 255                   

cac cgt ggc ggc ttc ccg ggg ggc gcc ggc gcg tcg gag cga ggc aag       1232
His Arg Gly Gly Phe Pro Gly Gly Ala Gly Ala Ser Glu Arg Gly Lys           
        260                 265                 270                       

ttc tcc tgc ccg cgc gcc ctc aag gtg ccc tcc tac ctc aac tac cac       1280
Phe Ser Cys Pro Arg Ala Leu Lys Val Pro Ser Tyr Leu Asn Tyr His           
    275                 280                 285                           

ttc ctg ggg gag aag gac tgc ggc gca cct tgt gag ccg acc aag gtg       1328
Phe Leu Gly Glu Lys Asp Cys Gly Ala Pro Cys Glu Pro Thr Lys Val           
290                 295                 300                 305           

tat ggg ctc atg tac ttc ggg ccc gag gag ctg cgc ttc tcg cgc acc       1376
Tyr Gly Leu Met Tyr Phe Gly Pro Glu Glu Leu Arg Phe Ser Arg Thr           
                310                 315                 320               

tgg att ggc att tgg tca gtg ctg tgc tgc gcc tcc acg ctc ttc acg       1424
Trp Ile Gly Ile Trp Ser Val Leu Cys Cys Ala Ser Thr Leu Phe Thr           
            325                 330                 335                   

gtg ctt acg tac ctg gtg gac atg cgg cgc ttc agc tac ccg gag cgg       1472
Val Leu Thr Tyr Leu Val Asp Met Arg Arg Phe Ser Tyr Pro Glu Arg           
        340                 345                 350                       

ccc atc atc ttc ttg tcc ggc tgt tac acg gcc gtg gcc gtg gcc tac       1520
Pro Ile Ile Phe Leu Ser Gly Cys Tyr Thr Ala Val Ala Val Ala Tyr           
    355                 360                 365                           

atc gcc ggc ttc ctc ctg gaa gac cga gtg gtg tgt aat gac aag ttc       1568
Ile Ala Gly Phe Leu Leu Glu Asp Arg Val Val Cys Asn Asp Lys Phe           
370                 375                 380                 385           

gcc gag gac ggg gca cgc act gtg gcg cag ggc acc aag aag gag ggc       1616
Ala Glu Asp Gly Ala Arg Thr Val Ala Gln Gly Thr Lys Lys Glu Gly           
                390                 395                 400               

tgc acc atc ctc ttc atg atg ctc tac ttc ttc agc atg gcc agc tcc       1664
Cys Thr Ile Leu Phe Met Met Leu Tyr Phe Phe Ser Met Ala Ser Ser           
            405                 410                 415                   

atc tgg tgg gtg atc ctg tcg ctc acc tgg ttc ctg gcg gct ggc atg       1712
Ile Trp Trp Val Ile Leu Ser Leu Thr Trp Phe Leu Ala Ala Gly Met           
        420                 425                 430                       

aag tgg ggc cac gag gcc atc gaa gcc aac tca cag tat ttt cac ctg       1760
Lys Trp Gly His Glu Ala Ile Glu Ala Asn Ser Gln Tyr Phe His Leu           
    435                 440                 445                           

gcc gcc tgg gct gtg ccg gcc atc aag acc atc acc atc ctg gcg ctg       1808
Ala Ala Trp Ala Val Pro Ala Ile Lys Thr Ile Thr Ile Leu Ala Leu           
450                 455                 460                 465           

ggc cag gtg gac ggc gat gtg ctg agc gga gtg tgc ttc gtg ggg ctt       1856
Gly Gln Val Asp Gly Asp Val Leu Ser Gly Val Cys Phe Val Gly Leu           
                470                 475                 480               

aac aac gtg gac gcg ctg cgt ggc ttc gtg ctg gcg ccc ctc ttc gtg       1904
Asn Asn Val Asp Ala Leu Arg Gly Phe Val Leu Ala Pro Leu Phe Val           
            485                 490                 495                   

tac ctg ttt atc ggc acg tcc ttt ctg ctg gcc ggc ttt gtg tcg ctc       1952
Tyr Leu Phe Ile Gly Thr Ser Phe Leu Leu Ala Gly Phe Val Ser Leu           
        500                 505                 510                       

ttc cgc atc cgc acc atc atg aag cac gat ggc acc aag acc gag aag       2000
Phe Arg Ile Arg Thr Ile Met Lys His Asp Gly Thr Lys Thr Glu Lys           
    515                 520                 525                           

ctg gag aag ctc atg gtg cgc att ggc gtc ttc agc gtg ctg tac act       2048
Leu Glu Lys Leu Met Val Arg Ile Gly Val Phe Ser Val Leu Tyr Thr           
530                 535                 540                 545           

gtg cca gcc acc atc gtc atc gcc tgc tac ttc tac gag cag gcc ttc       2096
Val Pro Ala Thr Ile Val Ile Ala Cys Tyr Phe Tyr Glu Gln Ala Phe           
                550                 555                 560               

cgg gac cag tgg gaa cgc agc tgg gtg gcc cag agc tgc aag agc tac       2144
Arg Asp Gln Trp Glu Arg Ser Trp Val Ala Gln Ser Cys Lys Ser Tyr           
            565                 570                 575                   

gct atc ccc tgc cct cac ctc cag gcg ggc gga ggc gcc ccg ccg cac       2192
Ala Ile Pro Cys Pro His Leu Gln Ala Gly Gly Gly Ala Pro Pro His           
        580                 585                 590                       

ccg ccc atg agc ccg gac ttc acg gtc ttc atg att aag tac ctt atg       2240
Pro Pro Met Ser Pro Asp Phe Thr Val Phe Met Ile Lys Tyr Leu Met           
    595                 600                 605                           

acg ctg atc gtg ggc atc acg tcg ggc ttc tgg atc tgg tcc ggc aag       2288
Thr Leu Ile Val Gly Ile Thr Ser Gly Phe Trp Ile Trp Ser Gly Lys           
610                 615                 620                 625           

acc ctc aac tcc tgg agg aag ttc tac acg agg ctc acc aac agc aaa       2336
Thr Leu Asn Ser Trp Arg Lys Phe Tyr Thr Arg Leu Thr Asn Ser Lys           
                630                 635                 640               

caa ggg gag act aca gtc tga gacccggggc tcagcccatg cccaggcctc          2387
Gln Gly Glu Thr Thr Val                                                   
            645                                                           

ggccggggcg cagcgatccc ccaaagccag cgccgtggag ttcgtgccaa tcctgacatc     2447

tcgaggtttc ctcactagac aactctcttt cgcaggctcc tttgaacaac tcagctcctg     2507

caaaagcttc cgtccctgag gcaaaaggac acgagggccc gactgccaga gggaggatgg     2567

acagacctct tgccctcaca ctctggtacc aggactgttc gcttttatga ttgtaaatag     2627

cctgtgtaag atttttgtaa gtatatttgt atttaaatga cgaccgatca cgcgtttttc     2687

tttttcaaaa gtttttaatt atttagggcg gtttaaccat ttgaggcttt tccttcttgc     2747

ccttttcgga gtattgcaaa ggagctaaaa ctggtgtgca accgcacagc gctcctggtc     2807

gtcctcgcgc gcctctccct accacgggtg ctcgggacgg ctgggcgcca gctccggggc     2867

gagttcagca ctgcggggtg cgactagggc tgcgctgcca gggtcacttc ccgcctcctc     2927

cttttgcccc ctccccctcc ttctgtcccc tccctttctt tcctggcttg aggtaggggc     2987

tcttaaggta cagaactcca caaaccttcc aaatctggag gagggccccc atacattaca     3047

attcctccct tgctcggcgg tggattgcga aggcccgtcc cttcgacttc ctgaagctgg     3107

atttttaact gtccagaact ttcctccaac ttcatggggg cccacgggtg tgggcgctgg     3167

cagtctcagc ctccctccac ggtcaccttc aacgcccaga cactcccttc tcccacctta     3227

gttggttaca gggtgagtga gataaccaat gccaaacttt ttgaagtcta atttttgagg     3287

ggtgagctca tttcattctc tagtgtctaa aacctggtat gggtttggcc agcgtcatgg     3347

aaagatgtgg ttactgagat ttgggaagaa gcatgaagct ttgtgtgggt tggaagagac     3407

tgaagatatg ggttataaaa tgttaattct aattgcatac ggatgcctgg caaccttgcc     3467

tttgagaatg agacagcctg cgcttagatt ttaccggtct gtaaaatgga aatgttgagg     3527

tcacctggaa agctttgtta aggagttgat gtttgctttc cttaacaaga cagcaaaacg     3587

taaacagaaa ttgaaaactt gaaggatatt tcagtgtcat ggacttcctc aaaatgaagt     3647

gctattttct tatttttaat caaataacta gacatatatc agaaacttta aaatgtaaaa     3707

gttgtacact ttcaacattt tattacgatt attattcagc agcacattct gaggggggaa     3767

caattcacac caccaataat aacctggtaa gatttcagga ggtaaagaag gtggaataat     3827

tgacggggag atagcgcctg aaataaacaa aatatgggca tgcatgctaa agggaaaatg     3887

tgtgcaggtc tactgcatta aatcctgtgt gctcctcttt tggatttaca gaaatgtgtc     3947

aaatgtaaat ctttcaaagc catttaaaaa tattcacttt agttctctgt gaagaagagg     4007

agaaaagcaa tcctcctgat tgtattgttt taaactttaa gaatttatca aaatgccggt     4067

acttaggacc taaatttatc tatgtctgtc atacgctaaa atgatattgg tctttgaatt     4127

tggtatacat ttattctgtt cactatcaca aaatcatcta tatttataga ggaatagaag     4187

tttatatata tataatacca tatttttaat ttcacaaata aaaaattcaa agttttgtac     4247

aaaattatat ggattttgtg cctgaaaata atagagcttg agctgtctga actattttac     4307

attttatggt gtctcatagc caatcccaca gtgtaaaaat tca                       4350


<210>  4
<211>  647
<212>  PRT
<213>  Homo sapiens

<400>  4

Met Ala Glu Glu Glu Ala Pro Lys Lys Ser Arg Ala Ala Gly Gly Gly 
1               5                   10                  15      


Ala Ser Trp Glu Leu Cys Ala Gly Ala Leu Ser Ala Arg Leu Ala Glu 
            20                  25                  30          


Glu Gly Ser Gly Asp Ala Gly Gly Arg Arg Arg Pro Pro Val Asp Pro 
        35                  40                  45              


Arg Arg Leu Ala Arg Gln Leu Leu Leu Leu Leu Trp Leu Leu Glu Ala 
    50                  55                  60                  


Pro Leu Leu Leu Gly Val Arg Ala Gln Ala Ala Gly Gln Gly Pro Gly 
65                  70                  75                  80  


Gln Gly Pro Gly Pro Gly Gln Gln Pro Pro Pro Pro Pro Gln Gln Gln 
                85                  90                  95      


Gln Ser Gly Gln Gln Tyr Asn Gly Glu Arg Gly Ile Ser Val Pro Asp 
            100                 105                 110         


His Gly Tyr Cys Gln Pro Ile Ser Ile Pro Leu Cys Thr Asp Ile Ala 
        115                 120                 125             


Tyr Asn Gln Thr Ile Met Pro Asn Leu Leu Gly His Thr Asn Gln Glu 
    130                 135                 140                 


Asp Ala Gly Leu Glu Val His Gln Phe Tyr Pro Leu Val Lys Val Gln 
145                 150                 155                 160 


Cys Ser Ala Glu Leu Lys Phe Phe Leu Cys Ser Met Tyr Ala Pro Val 
                165                 170                 175     


Cys Thr Val Leu Glu Gln Ala Leu Pro Pro Cys Arg Ser Leu Cys Glu 
            180                 185                 190         


Arg Ala Arg Gln Gly Cys Glu Ala Leu Met Asn Lys Phe Gly Phe Gln 
        195                 200                 205             


Trp Pro Asp Thr Leu Lys Cys Glu Lys Phe Pro Val His Gly Ala Gly 
    210                 215                 220                 


Glu Leu Cys Val Gly Gln Asn Thr Ser Asp Lys Gly Thr Pro Thr Pro 
225                 230                 235                 240 


Ser Leu Leu Pro Glu Phe Trp Thr Ser Asn Pro Gln His Gly Gly Gly 
                245                 250                 255     


Gly His Arg Gly Gly Phe Pro Gly Gly Ala Gly Ala Ser Glu Arg Gly 
            260                 265                 270         


Lys Phe Ser Cys Pro Arg Ala Leu Lys Val Pro Ser Tyr Leu Asn Tyr 
        275                 280                 285             


His Phe Leu Gly Glu Lys Asp Cys Gly Ala Pro Cys Glu Pro Thr Lys 
    290                 295                 300                 


Val Tyr Gly Leu Met Tyr Phe Gly Pro Glu Glu Leu Arg Phe Ser Arg 
305                 310                 315                 320 


Thr Trp Ile Gly Ile Trp Ser Val Leu Cys Cys Ala Ser Thr Leu Phe 
                325                 330                 335     


Thr Val Leu Thr Tyr Leu Val Asp Met Arg Arg Phe Ser Tyr Pro Glu 
            340                 345                 350         


Arg Pro Ile Ile Phe Leu Ser Gly Cys Tyr Thr Ala Val Ala Val Ala 
        355                 360                 365             


Tyr Ile Ala Gly Phe Leu Leu Glu Asp Arg Val Val Cys Asn Asp Lys 
    370                 375                 380                 


Phe Ala Glu Asp Gly Ala Arg Thr Val Ala Gln Gly Thr Lys Lys Glu 
385                 390                 395                 400 


Gly Cys Thr Ile Leu Phe Met Met Leu Tyr Phe Phe Ser Met Ala Ser 
                405                 410                 415     


Ser Ile Trp Trp Val Ile Leu Ser Leu Thr Trp Phe Leu Ala Ala Gly 
            420                 425                 430         


Met Lys Trp Gly His Glu Ala Ile Glu Ala Asn Ser Gln Tyr Phe His 
        435                 440                 445             


Leu Ala Ala Trp Ala Val Pro Ala Ile Lys Thr Ile Thr Ile Leu Ala 
    450                 455                 460                 


Leu Gly Gln Val Asp Gly Asp Val Leu Ser Gly Val Cys Phe Val Gly 
465                 470                 475                 480 


Leu Asn Asn Val Asp Ala Leu Arg Gly Phe Val Leu Ala Pro Leu Phe 
                485                 490                 495     


Val Tyr Leu Phe Ile Gly Thr Ser Phe Leu Leu Ala Gly Phe Val Ser 
            500                 505                 510         


Leu Phe Arg Ile Arg Thr Ile Met Lys His Asp Gly Thr Lys Thr Glu 
        515                 520                 525             


Lys Leu Glu Lys Leu Met Val Arg Ile Gly Val Phe Ser Val Leu Tyr 
    530                 535                 540                 


Thr Val Pro Ala Thr Ile Val Ile Ala Cys Tyr Phe Tyr Glu Gln Ala 
545                 550                 555                 560 


Phe Arg Asp Gln Trp Glu Arg Ser Trp Val Ala Gln Ser Cys Lys Ser 
                565                 570                 575     


Tyr Ala Ile Pro Cys Pro His Leu Gln Ala Gly Gly Gly Ala Pro Pro 
            580                 585                 590         


His Pro Pro Met Ser Pro Asp Phe Thr Val Phe Met Ile Lys Tyr Leu 
        595                 600                 605             


Met Thr Leu Ile Val Gly Ile Thr Ser Gly Phe Trp Ile Trp Ser Gly 
    610                 615                 620                 


Lys Thr Leu Asn Ser Trp Arg Lys Phe Tyr Thr Arg Leu Thr Asn Ser 
625                 630                 635                 640 


Lys Gln Gly Glu Thr Thr Val 
                645         


<210>  5
<211>  2838
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (191)..(1138)

<400>  5
gggtgggcgg gcggctgctc cggtccaggg gtggaggtcg gggccctgac ccgacgcagc       60

caggcggaag cgcggctgcc attggaggct gcttttacct gcgcggggcc cggggcgcaa      120

agtccgaggc gccgggggga ggaggcggcg gacggcagcg caggtgggcc cgcgctctcg      180

gccctgcaag atg ccc ctg aag ctg cgg ggg aag aag aag gcc aag tcc         229
           Met Pro Leu Lys Leu Arg Gly Lys Lys Lys Ala Lys Ser            
           1               5                   10                         

aag gag acc gcc ggg ctg gtg gag ggc gag ccg acg ggc gcg ggc ggc        277
Lys Glu Thr Ala Gly Leu Val Glu Gly Glu Pro Thr Gly Ala Gly Gly           
    15                  20                  25                            

ggg agc ctc tca gcg tcc cgg gct ccc gca cgc agg ctg gtc ttc cac        325
Gly Ser Leu Ser Ala Ser Arg Ala Pro Ala Arg Arg Leu Val Phe His           
30                  35                  40                  45            

gcg cag ctg gcg cac ggt agt gcc acg ggc cga gtg gag ggc ttc tcc        373
Ala Gln Leu Ala His Gly Ser Ala Thr Gly Arg Val Glu Gly Phe Ser           
                50                  55                  60                

agc atc cag gag ctc tac gcc cag atc gcg ggc gcg ttt gaa atc tcg        421
Ser Ile Gln Glu Leu Tyr Ala Gln Ile Ala Gly Ala Phe Glu Ile Ser           
            65                  70                  75                    

ccg tcg gag atc tta tat tgc act tta aac aca cct aaa att gac atg        469
Pro Ser Glu Ile Leu Tyr Cys Thr Leu Asn Thr Pro Lys Ile Asp Met           
        80                  85                  90                        

gaa aga ctc tta gga gga caa cta gga cta gaa gat ttc ata ttt gcc        517
Glu Arg Leu Leu Gly Gly Gln Leu Gly Leu Glu Asp Phe Ile Phe Ala           
    95                  100                 105                           

cat gtg aaa gga atc gaa aaa gaa gtg aat gtg tat aaa tct gag gat        565
His Val Lys Gly Ile Glu Lys Glu Val Asn Val Tyr Lys Ser Glu Asp           
110                 115                 120                 125           

tca ctt ggt ctc acc att aca gat aat ggt gtt ggc tat gct ttt ata        613
Ser Leu Gly Leu Thr Ile Thr Asp Asn Gly Val Gly Tyr Ala Phe Ile           
                130                 135                 140               

aag aga att aaa gat ggt ggt gtt att gac tca gtt aaa aca atc tgt        661
Lys Arg Ile Lys Asp Gly Gly Val Ile Asp Ser Val Lys Thr Ile Cys           
            145                 150                 155                   

gtt ggg gat cat att gaa tcc ata aat gga gaa aat att gtt ggg tgg        709
Val Gly Asp His Ile Glu Ser Ile Asn Gly Glu Asn Ile Val Gly Trp           
        160                 165                 170                       

cgt cac tat gat gtt gct aag aag tta aag gaa tta aaa aag gag gaa        757
Arg His Tyr Asp Val Ala Lys Lys Leu Lys Glu Leu Lys Lys Glu Glu           
    175                 180                 185                           

ctc ttt act atg aag tta ata gaa cct aag aag gca ttt gaa ata gag        805
Leu Phe Thr Met Lys Leu Ile Glu Pro Lys Lys Ala Phe Glu Ile Glu           
190                 195                 200                 205           

ctg agg tca aag gct gga aag tca tca gga gaa aaa att ggt tgt gga        853
Leu Arg Ser Lys Ala Gly Lys Ser Ser Gly Glu Lys Ile Gly Cys Gly           
                210                 215                 220               

agg gca aca ctt cgc ctg aga tca aaa ggt cct gcc acc gtg gaa gaa        901
Arg Ala Thr Leu Arg Leu Arg Ser Lys Gly Pro Ala Thr Val Glu Glu           
            225                 230                 235                   

atg cct tct gaa acc aaa gca aag gca att gaa aag att gat gat gtt        949
Met Pro Ser Glu Thr Lys Ala Lys Ala Ile Glu Lys Ile Asp Asp Val           
        240                 245                 250                       

ctt gag ttg tac atg gga att cga gat att gat tta gcc acc aca atg        997
Leu Glu Leu Tyr Met Gly Ile Arg Asp Ile Asp Leu Ala Thr Thr Met           
    255                 260                 265                           

ttt gaa gct gga aag gac aaa gta aat cca gat gaa ttt gct gtg gca       1045
Phe Glu Ala Gly Lys Asp Lys Val Asn Pro Asp Glu Phe Ala Val Ala           
270                 275                 280                 285           

ctt gac gaa act ctt gga gac ttt gcg ttc cca gac gaa ttt gtc ttt       1093
Leu Asp Glu Thr Leu Gly Asp Phe Ala Phe Pro Asp Glu Phe Val Phe           
                290                 295                 300               

gat gtt tgg gga gtc att ggt gat gcc aaa cga aga gga tta tga           1138
Asp Val Trp Gly Val Ile Gly Asp Ala Lys Arg Arg Gly Leu                   
            305                 310                 315                   

tgtgtacact ccatctctga agaaacaacc catcgttctt ttttttctct tttttaaaaa     1198

gtcctataag atctgttttt ggacaccttt actaactctg gtttaatttc atgtgtatgg     1258

aatatattct ttgaaatata attttggtaa ttttgatttc tgggcacttt ttaacattgc     1318

tgatgtagta tgcttaagag aaatgaccta aataaggatc aattgtaata ttcattcaaa     1378

aggtttttaa aagtaagttt taaggagtat ttctcgacag atgattttct tctccattaa     1438

tacccatgct ttgtttttca catataaata gatgatttca atagctttgt agtttttttt     1498

caaaatctta atgtaaacta ggattggagt atgatttacc tcatagtatc ttcactgtgt     1558

tatcctagtt tgaacaggat atgttcagga aatgaaaggt gaattatgcc ccttattggt     1618

ctagaagcat tggttttttt ttgatcctct gagtaaggga aggaagattc ctgtggcatg     1678

ttgatttcta tggccaactt tctctctttg taaaacaaag attgattgat tttcttgtat     1738

gcttctttat acatgctctt aaaacttgtg gttgaaatct gtgctgtgtg tgtgtgtctc     1798

tgcatgtgta aaagaagggt aaaaaagaga tgggtagggt agaactactt gcatttgatt     1858

tttttttcag tccttaaaac attatttctt tttttcactc atagccactt ttatgttacc     1918

ttttataagc actccaggga agattttata tttttttgta gagtttttgg aaagatattt     1978

actcaaaata actatgcttt agaacttttt tttttttttt ttttttggtt aaacagcagc     2038

actttttagt tccctaaact ttagaagaaa tgctatcaga aatagatttc cttccagtgg     2098

aaagaaagga ggaagggaga attgagaaaa tatattagtc tattatttta gagttctaat     2158

acactctaaa ttatagagaa aattgagagt aaatgactgt cttatcactc ttatttgaca     2218

tttcgtaggt gtaagagaaa tggaaatgaa tggtttcaac aaagatcatt taatacagca     2278

gagcatggca tgaccaagca tctttgtaaa gtgttagatg gaaaatgctg tgtgctgcca     2338

tggtaatcag aaataataac ctgttaggga tgtattctag gaaatcagaa gtagttctct     2398

tttcttgctg gattattgct tagataactc ttgttttctg gtaaaacttt agttgtattg     2458

ccatccactc ctttttcaaa tgagtttaat gccataaagc tgatattctt tgtccgatta     2518

atttgaaatc tgcacagaag ctgttttagt cattaatgtg taacaaaagt agcttataga     2578

atatggactg ccttattgct gttgcttatc atttgaaaat aaaatccagc tcaggttgta     2638

acttgttggt acttgtttag tgagttcgtt ttggaggttc tgaaatacct attaattctt     2698

aatattacct ctcttggaaa gacacaaaaa aagagctgtt atttttaggc ataagatgac     2758

ttaggaggcc catagaaacg ttctcgttta aacaacaaca acaaaataaa tttatcagca     2818

ctagaaaaaa aaaaaaaaaa                                                 2838


<210>  6
<211>  315
<212>  PRT
<213>  Homo sapiens

<400>  6

Met Pro Leu Lys Leu Arg Gly Lys Lys Lys Ala Lys Ser Lys Glu Thr 
1               5                   10                  15      


Ala Gly Leu Val Glu Gly Glu Pro Thr Gly Ala Gly Gly Gly Ser Leu 
            20                  25                  30          


Ser Ala Ser Arg Ala Pro Ala Arg Arg Leu Val Phe His Ala Gln Leu 
        35                  40                  45              


Ala His Gly Ser Ala Thr Gly Arg Val Glu Gly Phe Ser Ser Ile Gln 
    50                  55                  60                  


Glu Leu Tyr Ala Gln Ile Ala Gly Ala Phe Glu Ile Ser Pro Ser Glu 
65                  70                  75                  80  


Ile Leu Tyr Cys Thr Leu Asn Thr Pro Lys Ile Asp Met Glu Arg Leu 
                85                  90                  95      


Leu Gly Gly Gln Leu Gly Leu Glu Asp Phe Ile Phe Ala His Val Lys 
            100                 105                 110         


Gly Ile Glu Lys Glu Val Asn Val Tyr Lys Ser Glu Asp Ser Leu Gly 
        115                 120                 125             


Leu Thr Ile Thr Asp Asn Gly Val Gly Tyr Ala Phe Ile Lys Arg Ile 
    130                 135                 140                 


Lys Asp Gly Gly Val Ile Asp Ser Val Lys Thr Ile Cys Val Gly Asp 
145                 150                 155                 160 


His Ile Glu Ser Ile Asn Gly Glu Asn Ile Val Gly Trp Arg His Tyr 
                165                 170                 175     


Asp Val Ala Lys Lys Leu Lys Glu Leu Lys Lys Glu Glu Leu Phe Thr 
            180                 185                 190         


Met Lys Leu Ile Glu Pro Lys Lys Ala Phe Glu Ile Glu Leu Arg Ser 
        195                 200                 205             


Lys Ala Gly Lys Ser Ser Gly Glu Lys Ile Gly Cys Gly Arg Ala Thr 
    210                 215                 220                 


Leu Arg Leu Arg Ser Lys Gly Pro Ala Thr Val Glu Glu Met Pro Ser 
225                 230                 235                 240 


Glu Thr Lys Ala Lys Ala Ile Glu Lys Ile Asp Asp Val Leu Glu Leu 
                245                 250                 255     


Tyr Met Gly Ile Arg Asp Ile Asp Leu Ala Thr Thr Met Phe Glu Ala 
            260                 265                 270         


Gly Lys Asp Lys Val Asn Pro Asp Glu Phe Ala Val Ala Leu Asp Glu 
        275                 280                 285             


Thr Leu Gly Asp Phe Ala Phe Pro Asp Glu Phe Val Phe Asp Val Trp 
    290                 295                 300                 


Gly Val Ile Gly Asp Ala Lys Arg Arg Gly Leu 
305                 310                 315 


<210>  7
<211>  4018
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (247)..(2496)

<400>  7
gttccgcccg ccgctcttcc agctgagact cggcagcggc ggtcggagcg gctgccacgc       60

cgcacctgcc cgcgaggggg cgcgccaggc ccaggccgca gccgactgcc gcgctctctg      120

tccccgccct ccgccatccc cggactgcgc tcacctgtct gggccgctgg cctgggaggc      180

gggggccggc gggagccaag ccgaggaaag ggcggagcgg ctctccgggc gcgtcatcgg      240

agcacc atg gcg gag cta gga gct ggc ggc gac ggc cac agg ggc ggc         288
       Met Ala Glu Leu Gly Ala Gly Gly Asp Gly His Arg Gly Gly            
       1               5                   10                             

gac ggc gca gtg cga agc gaa aca gca ccc gac agc tac aaa gtg caa        336
Asp Gly Ala Val Arg Ser Glu Thr Ala Pro Asp Ser Tyr Lys Val Gln           
15                  20                  25                  30            

gat aag aaa aat gcc tcc agc cgc cct gcc tct gca att tca gga caa        384
Asp Lys Lys Asn Ala Ser Ser Arg Pro Ala Ser Ala Ile Ser Gly Gln           
                35                  40                  45                

aat aac aac cac tca gga aat aaa cca gac cct ccg cct gtg tta cgt        432
Asn Asn Asn His Ser Gly Asn Lys Pro Asp Pro Pro Pro Val Leu Arg           
            50                  55                  60                    

gtt gat gac cgg cag cgg ctg gcc cgg gag cga cgt gag gaa cgg gag        480
Val Asp Asp Arg Gln Arg Leu Ala Arg Glu Arg Arg Glu Glu Arg Glu           
        65                  70                  75                        

aaa cag cta gct gca aga gaa ata gtg tgg tta gaa aga gaa gag cga        528
Lys Gln Leu Ala Ala Arg Glu Ile Val Trp Leu Glu Arg Glu Glu Arg           
    80                  85                  90                            

gcc agg cag cac tac gag aag cac ctg gaa gag cgg aag aag agg ttg        576
Ala Arg Gln His Tyr Glu Lys His Leu Glu Glu Arg Lys Lys Arg Leu           
95                  100                 105                 110           

gag gag cag agg cag aag gag gag cgg agg agg gct gct gtg gag gag        624
Glu Glu Gln Arg Gln Lys Glu Glu Arg Arg Arg Ala Ala Val Glu Glu           
                115                 120                 125               

aag cgg agg cag aga ctt gag gag gac aaa gaa cgc cac gaa gct gtt        672
Lys Arg Arg Gln Arg Leu Glu Glu Asp Lys Glu Arg His Glu Ala Val           
            130                 135                 140                   

gta cgg cgc aca atg gaa agg agc cag aag cca aaa cag aag cat aac        720
Val Arg Arg Thr Met Glu Arg Ser Gln Lys Pro Lys Gln Lys His Asn           
        145                 150                 155                       

cgt tgg tcg tgg gga ggc tct ctc cat ggg agc cct agc atc cac agt        768
Arg Trp Ser Trp Gly Gly Ser Leu His Gly Ser Pro Ser Ile His Ser           
    160                 165                 170                           

gca gat cca gac agg cgg tca gtt tcc acc atg aat ctt tcg aaa tat        816
Ala Asp Pro Asp Arg Arg Ser Val Ser Thr Met Asn Leu Ser Lys Tyr           
175                 180                 185                 190           

gtt gat ccc gtc att agc aag cgg ctc tcc tct tca tct gca act tta        864
Val Asp Pro Val Ile Ser Lys Arg Leu Ser Ser Ser Ser Ala Thr Leu           
                195                 200                 205               

cta aat tct cca gat aga gct cgc cgc ctg cag ctc agc cca tgg gag        912
Leu Asn Ser Pro Asp Arg Ala Arg Arg Leu Gln Leu Ser Pro Trp Glu           
            210                 215                 220                   

agc agc gtt gtt aac aga ctc ctg acg ccc aca cat tcg ttc ctg gcc        960
Ser Ser Val Val Asn Arg Leu Leu Thr Pro Thr His Ser Phe Leu Ala           
        225                 230                 235                       

aga agt aaa agc aca gct gcc ttg tct gga gaa gca gca tct tgc agc       1008
Arg Ser Lys Ser Thr Ala Ala Leu Ser Gly Glu Ala Ala Ser Cys Ser           
    240                 245                 250                           

ccc atc atc atg ccc tac aaa gct gca cac tct aga aat tcg atg gat       1056
Pro Ile Ile Met Pro Tyr Lys Ala Ala His Ser Arg Asn Ser Met Asp           
255                 260                 265                 270           

cga cca aaa ctc ttt gta aca cca cct gag ggc tct tct cgc agg agg       1104
Arg Pro Lys Leu Phe Val Thr Pro Pro Glu Gly Ser Ser Arg Arg Arg           
                275                 280                 285               

atc att cat ggc aca gcg agc tat aaa aaa gaa aga gag aga gaa aat       1152
Ile Ile His Gly Thr Ala Ser Tyr Lys Lys Glu Arg Glu Arg Glu Asn           
            290                 295                 300                   

gta ctc ttc ctc aca tct ggc acc cga agg gct gta tct cca tct aat       1200
Val Leu Phe Leu Thr Ser Gly Thr Arg Arg Ala Val Ser Pro Ser Asn           
        305                 310                 315                       

ccc aaa gca aga caa cca gct cgc tcc cga ctt tgg ctt ccg tcc aag       1248
Pro Lys Ala Arg Gln Pro Ala Arg Ser Arg Leu Trp Leu Pro Ser Lys           
    320                 325                 330                           

tct ctt cct cat ttg cct ggc aca ccc aga ccg aca tcc tcc ttg cca       1296
Ser Leu Pro His Leu Pro Gly Thr Pro Arg Pro Thr Ser Ser Leu Pro           
335                 340                 345                 350           

ccc ggc tca gtc aaa gct gct cct gct cag gtc cgg ccc cca tcc ccc       1344
Pro Gly Ser Val Lys Ala Ala Pro Ala Gln Val Arg Pro Pro Ser Pro           
                355                 360                 365               

ggc aac atc cgc cct gtc aag agg gaa gtc aaa gtg gag cct gag aag       1392
Gly Asn Ile Arg Pro Val Lys Arg Glu Val Lys Val Glu Pro Glu Lys           
            370                 375                 380                   

aaa gat cct gag aag gaa cct cag aaa gtt gcc aat gag ccc tca cta       1440
Lys Asp Pro Glu Lys Glu Pro Gln Lys Val Ala Asn Glu Pro Ser Leu           
        385                 390                 395                       

aag ggc aga gca cct tta gtg aag gta gaa gaa gcc aca gtt gaa gag       1488
Lys Gly Arg Ala Pro Leu Val Lys Val Glu Glu Ala Thr Val Glu Glu           
    400                 405                 410                           

cgg aca cct gct gaa cca gaa gtt ggc cct gct gct cca gcc atg gcc       1536
Arg Thr Pro Ala Glu Pro Glu Val Gly Pro Ala Ala Pro Ala Met Ala           
415                 420                 425                 430           

cca gct cca gcc tcg gcc cca gct cca gcc tcg gcc cca gct cca gcc       1584
Pro Ala Pro Ala Ser Ala Pro Ala Pro Ala Ser Ala Pro Ala Pro Ala           
                435                 440                 445               

ccg gtc ccc acc cca gcc atg gtc tca gcc ccg tca tcc act gtg aat       1632
Pro Val Pro Thr Pro Ala Met Val Ser Ala Pro Ser Ser Thr Val Asn           
            450                 455                 460                   

gcc agt gct tct gtt aag act tct gca ggc acc acc gac cca gag gag       1680
Ala Ser Ala Ser Val Lys Thr Ser Ala Gly Thr Thr Asp Pro Glu Glu           
        465                 470                 475                       

gcc aca agg ctt cta gct gag aag agg cgg ctg gcc cga gag cag aga       1728
Ala Thr Arg Leu Leu Ala Glu Lys Arg Arg Leu Ala Arg Glu Gln Arg           
    480                 485                 490                           

gaa aag gaa gaa agg gag agg agg gag cag gaa gag ctt gaa aga caa       1776
Glu Lys Glu Glu Arg Glu Arg Arg Glu Gln Glu Glu Leu Glu Arg Gln           
495                 500                 505                 510           

aag aga gag gaa ttg gct caa cgt gtg gct gaa gag agg acg act cgc       1824
Lys Arg Glu Glu Leu Ala Gln Arg Val Ala Glu Glu Arg Thr Thr Arg           
                515                 520                 525               

cgt gag gag gag tcg cgc agg ctg gaa gcc gag cag gcc cgg gag aag       1872
Arg Glu Glu Glu Ser Arg Arg Leu Glu Ala Glu Gln Ala Arg Glu Lys           
            530                 535                 540                   

gag gag cag ctg cag cgg cag gcg gag gag cgg gcg ctg cgc gag cgg       1920
Glu Glu Gln Leu Gln Arg Gln Ala Glu Glu Arg Ala Leu Arg Glu Arg           
        545                 550                 555                       

gag gag gca gag cgc gcc cag agg cag aaa gaa gaa gaa gct cgc gtt       1968
Glu Glu Ala Glu Arg Ala Gln Arg Gln Lys Glu Glu Glu Ala Arg Val           
    560                 565                 570                           

cgt gaa gaa gca gag agg gtc cgg cag gaa cga gag aag cat ttc cag       2016
Arg Glu Glu Ala Glu Arg Val Arg Gln Glu Arg Glu Lys His Phe Gln           
575                 580                 585                 590           

aga gaa gag caa gag cgc ctg gag aga aag aag cga ctt gag gag att       2064
Arg Glu Glu Gln Glu Arg Leu Glu Arg Lys Lys Arg Leu Glu Glu Ile           
                595                 600                 605               

atg aaa aga acc agg aga aca gaa gct aca gat aag aaa acc agt gat       2112
Met Lys Arg Thr Arg Arg Thr Glu Ala Thr Asp Lys Lys Thr Ser Asp           
            610                 615                 620                   

cag aga aac ggt gat ata gcc aag gga gct ctc act gga gga aca gag       2160
Gln Arg Asn Gly Asp Ile Ala Lys Gly Ala Leu Thr Gly Gly Thr Glu           
        625                 630                 635                       

gtg tct gca ctt cca tgt aca aca aac gct ccg gga aat gga aag cca       2208
Val Ser Ala Leu Pro Cys Thr Thr Asn Ala Pro Gly Asn Gly Lys Pro           
    640                 645                 650                           

gtt ggc agc cca cat gtg gtt acc tca cac cag tca aaa gtg aca gtg       2256
Val Gly Ser Pro His Val Val Thr Ser His Gln Ser Lys Val Thr Val           
655                 660                 665                 670           

gag agc act ccc gat ttg gaa aaa caa cca aat gaa aat ggt gta tct       2304
Glu Ser Thr Pro Asp Leu Glu Lys Gln Pro Asn Glu Asn Gly Val Ser           
                675                 680                 685               

gtt cag aat gaa aat ttt gaa gaa att ata aac tta ccc att gga tct       2352
Val Gln Asn Glu Asn Phe Glu Glu Ile Ile Asn Leu Pro Ile Gly Ser           
            690                 695                 700                   

aaa cca tcc aga tta gat gtc acc aac agt gag agc cca gaa att cct       2400
Lys Pro Ser Arg Leu Asp Val Thr Asn Ser Glu Ser Pro Glu Ile Pro           
        705                 710                 715                       

ttg aat cca att ttg gcc ttt gat gat gaa ggg aca ctt ggg ccc ctg       2448
Leu Asn Pro Ile Leu Ala Phe Asp Asp Glu Gly Thr Leu Gly Pro Leu           
    720                 725                 730                           

cct cag gta gat ggt gtt cag aca cag cag act gca gaa gtt ata tga       2496
Pro Gln Val Asp Gly Val Gln Thr Gln Gln Thr Ala Glu Val Ile               
735                 740                 745                               

gtgtttcttc tgaagaacca aagctgaaat ttaatgagaa tttctacaat taatggaatt     2556

cctttcctgc tataaaggag catcccctcc acccgttttc tagagttctt gaccatcatt     2616

ttgaaaagat ttattaaaac tagctaaaga caacagactg gatagctttt ctaataattt     2676

tcatcaatag gaaaaaagaa atacgtctca ttcttcaata ctttaaaatg gctttttcca     2736

gtgtgctcct tcttagcaat caatattttt ctgcattctt taaaagacaa gagaatttgg     2796

ttataaaaga aatgggctga ctaggcatga tttttttggt cttaaaagct taacatgtaa     2856

aattggcaaa aaaaattttt taccttttat aatacttgaa aaataagtac ctctttgttc     2916

tacaagtaga atgaatagga gaagagttta agcctgtttt tttaaaatat tattgcaaag     2976

agctctattt gtagaagcaa attataggca gattaccagg ttcttataaa tacagcttgt     3036

acatggacat tctgcaaacc cagctgtcac atttttcttg caactccttt tgcaaaagca     3096

gactaaaatg ttttaaaatg tgaaaaaaca ttattttttc aaagcaagaa aataatttac     3156

tgccctctta cataatgtat ttataaagtt tttccagata aactaatcaa ataaattaga     3216

ataatgtgac aacattacaa atttaatttg ttagctgcat tccttctgat gttaccacga     3276

tagaatgtta ctgatgattc agggctattt ctgaagtctg tatgttgctg ctgtccccag     3336

tgatggtgga cttatctttg ccttacctga tcacaaatta tgttggggaa aataaagatt     3396

taatatttct ttaaatagaa aaagaatttg gttttgctcg tttaagagca atgagaaaat     3456

gatggaatgt tgactgtgtt tggcacacag gacacggacc ttcatggaag tccttgctct     3516

gcgtggcatc tgtcagcttt tcacctttca ttcttattct tcacttttgc tgctgagcct     3576

agctgtacaa acttgcactt tcatttgcta atataaattc agttttattt taccatttta     3636

gagactacta atgattaaat gtagaaggag agggtgcaca tgtttttatg tggagtgttt     3696

aaaagataaa tttataccac tgtaatgtgc agcttttatt aaaagagaaa ttggttgaac     3756

tgctaggttg aatgagagac ttcatctatt ggactatttt ttttaatcca ggcatatggt     3816

ctttagtaat ggcttgtaat ttgtgaaaac attaatttgg gggttttccc tgttttcagt     3876

tgtccatgta cacatagtca ttatattaga aaagaaagct gttcaacaaa cttgtttaat     3936

ttgtttaaat caacatagca tgaaacacca aataaaatgt ttgacatagt tttaaaaaaa     3996

aaaaaaaaaa aaaaaaaaaa aa                                              4018


<210>  8
<211>  749
<212>  PRT
<213>  Homo sapiens

<400>  8

Met Ala Glu Leu Gly Ala Gly Gly Asp Gly His Arg Gly Gly Asp Gly 
1               5                   10                  15      


Ala Val Arg Ser Glu Thr Ala Pro Asp Ser Tyr Lys Val Gln Asp Lys 
            20                  25                  30          


Lys Asn Ala Ser Ser Arg Pro Ala Ser Ala Ile Ser Gly Gln Asn Asn 
        35                  40                  45              


Asn His Ser Gly Asn Lys Pro Asp Pro Pro Pro Val Leu Arg Val Asp 
    50                  55                  60                  


Asp Arg Gln Arg Leu Ala Arg Glu Arg Arg Glu Glu Arg Glu Lys Gln 
65                  70                  75                  80  


Leu Ala Ala Arg Glu Ile Val Trp Leu Glu Arg Glu Glu Arg Ala Arg 
                85                  90                  95      


Gln His Tyr Glu Lys His Leu Glu Glu Arg Lys Lys Arg Leu Glu Glu 
            100                 105                 110         


Gln Arg Gln Lys Glu Glu Arg Arg Arg Ala Ala Val Glu Glu Lys Arg 
        115                 120                 125             


Arg Gln Arg Leu Glu Glu Asp Lys Glu Arg His Glu Ala Val Val Arg 
    130                 135                 140                 


Arg Thr Met Glu Arg Ser Gln Lys Pro Lys Gln Lys His Asn Arg Trp 
145                 150                 155                 160 


Ser Trp Gly Gly Ser Leu His Gly Ser Pro Ser Ile His Ser Ala Asp 
                165                 170                 175     


Pro Asp Arg Arg Ser Val Ser Thr Met Asn Leu Ser Lys Tyr Val Asp 
            180                 185                 190         


Pro Val Ile Ser Lys Arg Leu Ser Ser Ser Ser Ala Thr Leu Leu Asn 
        195                 200                 205             


Ser Pro Asp Arg Ala Arg Arg Leu Gln Leu Ser Pro Trp Glu Ser Ser 
    210                 215                 220                 


Val Val Asn Arg Leu Leu Thr Pro Thr His Ser Phe Leu Ala Arg Ser 
225                 230                 235                 240 


Lys Ser Thr Ala Ala Leu Ser Gly Glu Ala Ala Ser Cys Ser Pro Ile 
                245                 250                 255     


Ile Met Pro Tyr Lys Ala Ala His Ser Arg Asn Ser Met Asp Arg Pro 
            260                 265                 270         


Lys Leu Phe Val Thr Pro Pro Glu Gly Ser Ser Arg Arg Arg Ile Ile 
        275                 280                 285             


His Gly Thr Ala Ser Tyr Lys Lys Glu Arg Glu Arg Glu Asn Val Leu 
    290                 295                 300                 


Phe Leu Thr Ser Gly Thr Arg Arg Ala Val Ser Pro Ser Asn Pro Lys 
305                 310                 315                 320 


Ala Arg Gln Pro Ala Arg Ser Arg Leu Trp Leu Pro Ser Lys Ser Leu 
                325                 330                 335     


Pro His Leu Pro Gly Thr Pro Arg Pro Thr Ser Ser Leu Pro Pro Gly 
            340                 345                 350         


Ser Val Lys Ala Ala Pro Ala Gln Val Arg Pro Pro Ser Pro Gly Asn 
        355                 360                 365             


Ile Arg Pro Val Lys Arg Glu Val Lys Val Glu Pro Glu Lys Lys Asp 
    370                 375                 380                 


Pro Glu Lys Glu Pro Gln Lys Val Ala Asn Glu Pro Ser Leu Lys Gly 
385                 390                 395                 400 


Arg Ala Pro Leu Val Lys Val Glu Glu Ala Thr Val Glu Glu Arg Thr 
                405                 410                 415     


Pro Ala Glu Pro Glu Val Gly Pro Ala Ala Pro Ala Met Ala Pro Ala 
            420                 425                 430         


Pro Ala Ser Ala Pro Ala Pro Ala Ser Ala Pro Ala Pro Ala Pro Val 
        435                 440                 445             


Pro Thr Pro Ala Met Val Ser Ala Pro Ser Ser Thr Val Asn Ala Ser 
    450                 455                 460                 


Ala Ser Val Lys Thr Ser Ala Gly Thr Thr Asp Pro Glu Glu Ala Thr 
465                 470                 475                 480 


Arg Leu Leu Ala Glu Lys Arg Arg Leu Ala Arg Glu Gln Arg Glu Lys 
                485                 490                 495     


Glu Glu Arg Glu Arg Arg Glu Gln Glu Glu Leu Glu Arg Gln Lys Arg 
            500                 505                 510         


Glu Glu Leu Ala Gln Arg Val Ala Glu Glu Arg Thr Thr Arg Arg Glu 
        515                 520                 525             


Glu Glu Ser Arg Arg Leu Glu Ala Glu Gln Ala Arg Glu Lys Glu Glu 
    530                 535                 540                 


Gln Leu Gln Arg Gln Ala Glu Glu Arg Ala Leu Arg Glu Arg Glu Glu 
545                 550                 555                 560 


Ala Glu Arg Ala Gln Arg Gln Lys Glu Glu Glu Ala Arg Val Arg Glu 
                565                 570                 575     


Glu Ala Glu Arg Val Arg Gln Glu Arg Glu Lys His Phe Gln Arg Glu 
            580                 585                 590         


Glu Gln Glu Arg Leu Glu Arg Lys Lys Arg Leu Glu Glu Ile Met Lys 
        595                 600                 605             


Arg Thr Arg Arg Thr Glu Ala Thr Asp Lys Lys Thr Ser Asp Gln Arg 
    610                 615                 620                 


Asn Gly Asp Ile Ala Lys Gly Ala Leu Thr Gly Gly Thr Glu Val Ser 
625                 630                 635                 640 


Ala Leu Pro Cys Thr Thr Asn Ala Pro Gly Asn Gly Lys Pro Val Gly 
                645                 650                 655     


Ser Pro His Val Val Thr Ser His Gln Ser Lys Val Thr Val Glu Ser 
            660                 665                 670         


Thr Pro Asp Leu Glu Lys Gln Pro Asn Glu Asn Gly Val Ser Val Gln 
        675                 680                 685             


Asn Glu Asn Phe Glu Glu Ile Ile Asn Leu Pro Ile Gly Ser Lys Pro 
    690                 695                 700                 


Ser Arg Leu Asp Val Thr Asn Ser Glu Ser Pro Glu Ile Pro Leu Asn 
705                 710                 715                 720 


Pro Ile Leu Ala Phe Asp Asp Glu Gly Thr Leu Gly Pro Leu Pro Gln 
                725                 730                 735     


Val Asp Gly Val Gln Thr Gln Gln Thr Ala Glu Val Ile 
            740                 745                 


<210>  9
<211>  2651
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (219)..(1841)

<400>  9
tctttttctt ttttttttaa gaaaaactag tgacattgca gagaaggacg cttcctctct       60

atcttttggc gcattagtga agggggtatt ctattttgtt aaagcgccca agggggcgca      120

gggaccttgg agagaagagt ggggaggaaa gaggaagggt gggtgggggg cagagggcga      180

gtcggcggcg gcgagggcaa gctctttctt gcggcacg atg ccg tct ctg ctg gtg      236
                                          Met Pro Ser Leu Leu Val         
                                          1               5               

ctc act ttc tcc ccg tgc gta cta ctc ggc tgg gcg ttg ctg gcc ggc        284
Leu Thr Phe Ser Pro Cys Val Leu Leu Gly Trp Ala Leu Leu Ala Gly           
            10                  15                  20                    

ggc acc ggt ggc ggt ggc gtt ggc ggc ggc ggc ggt ggc gcg ggc ata        332
Gly Thr Gly Gly Gly Gly Val Gly Gly Gly Gly Gly Gly Ala Gly Ile           
        25                  30                  35                        

ggc ggc gga cgc cag gag aga gag gcg ctg ccg cca cag aag atc gag        380
Gly Gly Gly Arg Gln Glu Arg Glu Ala Leu Pro Pro Gln Lys Ile Glu           
    40                  45                  50                            

gtg ctg gtg tta ctg ccc cag gat gac tcg tac ttg ttt tca ctc acc        428
Val Leu Val Leu Leu Pro Gln Asp Asp Ser Tyr Leu Phe Ser Leu Thr           
55                  60                  65                  70            

cgg gtg cgg ccg gcc atc gag tat gct ctg cgc agc gtg gag ggc aac        476
Arg Val Arg Pro Ala Ile Glu Tyr Ala Leu Arg Ser Val Glu Gly Asn           
                75                  80                  85                

ggg act ggg agg cgg ctt ctg ccg ccg ggc act cgc ttc cag gtg gct        524
Gly Thr Gly Arg Arg Leu Leu Pro Pro Gly Thr Arg Phe Gln Val Ala           
            90                  95                  100                   

tac gag gat tca gac tgt ggg aac cgt gcg ctc ttc agc ttg gtg gac        572
Tyr Glu Asp Ser Asp Cys Gly Asn Arg Ala Leu Phe Ser Leu Val Asp           
        105                 110                 115                       

cgc gtg gcg gcg gcg cgg ggc gcc aag cca gac ctt atc ctg ggg cca        620
Arg Val Ala Ala Ala Arg Gly Ala Lys Pro Asp Leu Ile Leu Gly Pro           
    120                 125                 130                           

gtg tgc gag tat gca gca gcg cca gtg gcc cgg ctt gca tcg cac tgg        668
Val Cys Glu Tyr Ala Ala Ala Pro Val Ala Arg Leu Ala Ser His Trp           
135                 140                 145                 150           

gac ctg ccc atg ctg tcg gct ggg gcg ctg gcc gct ggc ttc cag cac        716
Asp Leu Pro Met Leu Ser Ala Gly Ala Leu Ala Ala Gly Phe Gln His           
                155                 160                 165               

aag gac tct gag tac tcg cac ctc acg cgc gtg gcg ccc gcc tac gcc        764
Lys Asp Ser Glu Tyr Ser His Leu Thr Arg Val Ala Pro Ala Tyr Ala           
            170                 175                 180                   

aag atg ggc gag atg atg ctc gcc ctg ttc cgc cac cac cac tgg agc        812
Lys Met Gly Glu Met Met Leu Ala Leu Phe Arg His His His Trp Ser           
        185                 190                 195                       

cgc gct gca ctg gtc tac agc gac gac aag ctg gag cgg aac tgc tac        860
Arg Ala Ala Leu Val Tyr Ser Asp Asp Lys Leu Glu Arg Asn Cys Tyr           
    200                 205                 210                           

ttc acc ctc gag ggg gtc cac gag gtc ttc cag gag gag ggt ttg cac        908
Phe Thr Leu Glu Gly Val His Glu Val Phe Gln Glu Glu Gly Leu His           
215                 220                 225                 230           

acg tcc atc tac agt ttc gac gag acc aaa gac ttg gat ctg gaa gac        956
Thr Ser Ile Tyr Ser Phe Asp Glu Thr Lys Asp Leu Asp Leu Glu Asp           
                235                 240                 245               

atc gtg cgc aat atc cag gcc agt gag aga gtg gtg atc atg tgt gcg       1004
Ile Val Arg Asn Ile Gln Ala Ser Glu Arg Val Val Ile Met Cys Ala           
            250                 255                 260                   

agc agt gac acc atc cgg agc atc atg ctg gtg gcg cac agg cat ggc       1052
Ser Ser Asp Thr Ile Arg Ser Ile Met Leu Val Ala His Arg His Gly           
        265                 270                 275                       

atg acc agt gga gac tac gcc ttc ttc aac att gag ctc ttc aac agc       1100
Met Thr Ser Gly Asp Tyr Ala Phe Phe Asn Ile Glu Leu Phe Asn Ser           
    280                 285                 290                           

tct tcc tat gga gat ggc tca tgg aag aga gga gac aaa cac gac ttt       1148
Ser Ser Tyr Gly Asp Gly Ser Trp Lys Arg Gly Asp Lys His Asp Phe           
295                 300                 305                 310           

gaa gct aag caa gca tac tcg tcc ctc cag aca gtc act cta ctg agg       1196
Glu Ala Lys Gln Ala Tyr Ser Ser Leu Gln Thr Val Thr Leu Leu Arg           
                315                 320                 325               

aca gtg aaa cct gag ttt gag aag ttt tcc atg gag gtg aaa agt tca       1244
Thr Val Lys Pro Glu Phe Glu Lys Phe Ser Met Glu Val Lys Ser Ser           
            330                 335                 340                   

gtt gag aaa caa ggg ctc aat atg gag gat tac gtt aac atg ttt gtt       1292
Val Glu Lys Gln Gly Leu Asn Met Glu Asp Tyr Val Asn Met Phe Val           
        345                 350                 355                       

gaa gga ttc cac gat gcc atc ctc ctc tac gtc ttg gct cta cat gaa       1340
Glu Gly Phe His Asp Ala Ile Leu Leu Tyr Val Leu Ala Leu His Glu           
    360                 365                 370                           

gta ctc aga gct ggt tac agc aaa aag gat gga ggg aaa att ata cag       1388
Val Leu Arg Ala Gly Tyr Ser Lys Lys Asp Gly Gly Lys Ile Ile Gln           
375                 380                 385                 390           

cag act tgg aac aga aca ttt gaa ggt atc gcc ggg cag gtg tcc ata       1436
Gln Thr Trp Asn Arg Thr Phe Glu Gly Ile Ala Gly Gln Val Ser Ile           
                395                 400                 405               

gat gcc aac gga gac cga tat ggg gat ttc tct gtg att gcc atg act       1484
Asp Ala Asn Gly Asp Arg Tyr Gly Asp Phe Ser Val Ile Ala Met Thr           
            410                 415                 420                   

gat gtg gag gcg ggc acc cag gag gtt att ggt gat tat ttt gga aaa       1532
Asp Val Glu Ala Gly Thr Gln Glu Val Ile Gly Asp Tyr Phe Gly Lys           
        425                 430                 435                       

gaa ggt cgt ttt gaa atg cgg ccg aat gtc aaa tat cct tgg ggc cct       1580
Glu Gly Arg Phe Glu Met Arg Pro Asn Val Lys Tyr Pro Trp Gly Pro           
    440                 445                 450                           

tta aaa ctg aga ata gat gaa aac cga att gta gag cat aca aac agc       1628
Leu Lys Leu Arg Ile Asp Glu Asn Arg Ile Val Glu His Thr Asn Ser           
455                 460                 465                 470           

tct ccc tgc aaa tca tgt ggc cta gaa gaa tcg gca gtg aca gga att       1676
Ser Pro Cys Lys Ser Cys Gly Leu Glu Glu Ser Ala Val Thr Gly Ile           
                475                 480                 485               

gtc gtg ggg gct tta cta gga gct ggc ttg cta atg gcc ttc tac ttt       1724
Val Val Gly Ala Leu Leu Gly Ala Gly Leu Leu Met Ala Phe Tyr Phe           
            490                 495                 500                   

ttc agg aag aaa tac aga ata acc att gag agg cga acc cag caa gaa       1772
Phe Arg Lys Lys Tyr Arg Ile Thr Ile Glu Arg Arg Thr Gln Gln Glu           
        505                 510                 515                       

gaa agt aac ctt gga aaa cat cgg gaa tta cgg gaa gat tcc atc aga       1820
Glu Ser Asn Leu Gly Lys His Arg Glu Leu Arg Glu Asp Ser Ile Arg           
    520                 525                 530                           

tcc cat ttt tca gta gct taa aggaagcccc ccactttttt tttttctgcc          1871
Ser His Phe Ser Val Ala                                                   
535                 540                                                   

tgagattctt taaggagata gacgggttga aagacatcaa tgaaacagaa ggggcgttct     1931

tgaagaattc ataattttaa gcagttagta atttcatttt aaaatttctg tagaagctca     1991

ggaattatga ttaatcacca tctgcctcca ggcctttcat ctcatgacaa acaaatataa     2051

taatgatatc gtgtcactct gttaaatgtt catactgttt caagcccata tgattagatt     2111

tatgttttta aaatctgttg tctccatatc ttgatggctt ttgggagcat ttcacacaag     2171

gatataaaat gcggttttct taaatgaaat gttttgtagc tagaataaaa tcatttttac     2231

aagtacagca ttcttggaaa gaatttaaca cccaaaaagg ggaaaatgta atgaaaaatc     2291

tcaaggttgg aaatacagcc ttactctctc tagagctgga ggacaggttt gtggttgagg     2351

acttctctgt ccgatgtcta cattcaggtt ctgacttcat atcttgaaaa aggatttcct     2411

ccctgtcttt ttcagtgtct cataaacgct actctggatt gttgtaaata ttagtgagat     2471

gggaggattt acagaagaaa agcaagtcaa aaatatttcc tttttgatgt aaaaaaaaaa     2531

agccctattt cgcactaaca ttttatttta caagtatttt aatcttatat tttggtatta     2591

gaaaaatttg tctatttttt cattttgaag attaaatgtt gcttacattt taaaaaaaaa     2651


<210>  10
<211>  540
<212>  PRT
<213>  Homo sapiens

<400>  10

Met Pro Ser Leu Leu Val Leu Thr Phe Ser Pro Cys Val Leu Leu Gly 
1               5                   10                  15      


Trp Ala Leu Leu Ala Gly Gly Thr Gly Gly Gly Gly Val Gly Gly Gly 
            20                  25                  30          


Gly Gly Gly Ala Gly Ile Gly Gly Gly Arg Gln Glu Arg Glu Ala Leu 
        35                  40                  45              


Pro Pro Gln Lys Ile Glu Val Leu Val Leu Leu Pro Gln Asp Asp Ser 
    50                  55                  60                  


Tyr Leu Phe Ser Leu Thr Arg Val Arg Pro Ala Ile Glu Tyr Ala Leu 
65                  70                  75                  80  


Arg Ser Val Glu Gly Asn Gly Thr Gly Arg Arg Leu Leu Pro Pro Gly 
                85                  90                  95      


Thr Arg Phe Gln Val Ala Tyr Glu Asp Ser Asp Cys Gly Asn Arg Ala 
            100                 105                 110         


Leu Phe Ser Leu Val Asp Arg Val Ala Ala Ala Arg Gly Ala Lys Pro 
        115                 120                 125             


Asp Leu Ile Leu Gly Pro Val Cys Glu Tyr Ala Ala Ala Pro Val Ala 
    130                 135                 140                 


Arg Leu Ala Ser His Trp Asp Leu Pro Met Leu Ser Ala Gly Ala Leu 
145                 150                 155                 160 


Ala Ala Gly Phe Gln His Lys Asp Ser Glu Tyr Ser His Leu Thr Arg 
                165                 170                 175     


Val Ala Pro Ala Tyr Ala Lys Met Gly Glu Met Met Leu Ala Leu Phe 
            180                 185                 190         


Arg His His His Trp Ser Arg Ala Ala Leu Val Tyr Ser Asp Asp Lys 
        195                 200                 205             


Leu Glu Arg Asn Cys Tyr Phe Thr Leu Glu Gly Val His Glu Val Phe 
    210                 215                 220                 


Gln Glu Glu Gly Leu His Thr Ser Ile Tyr Ser Phe Asp Glu Thr Lys 
225                 230                 235                 240 


Asp Leu Asp Leu Glu Asp Ile Val Arg Asn Ile Gln Ala Ser Glu Arg 
                245                 250                 255     


Val Val Ile Met Cys Ala Ser Ser Asp Thr Ile Arg Ser Ile Met Leu 
            260                 265                 270         


Val Ala His Arg His Gly Met Thr Ser Gly Asp Tyr Ala Phe Phe Asn 
        275                 280                 285             


Ile Glu Leu Phe Asn Ser Ser Ser Tyr Gly Asp Gly Ser Trp Lys Arg 
    290                 295                 300                 


Gly Asp Lys His Asp Phe Glu Ala Lys Gln Ala Tyr Ser Ser Leu Gln 
305                 310                 315                 320 


Thr Val Thr Leu Leu Arg Thr Val Lys Pro Glu Phe Glu Lys Phe Ser 
                325                 330                 335     


Met Glu Val Lys Ser Ser Val Glu Lys Gln Gly Leu Asn Met Glu Asp 
            340                 345                 350         


Tyr Val Asn Met Phe Val Glu Gly Phe His Asp Ala Ile Leu Leu Tyr 
        355                 360                 365             


Val Leu Ala Leu His Glu Val Leu Arg Ala Gly Tyr Ser Lys Lys Asp 
    370                 375                 380                 


Gly Gly Lys Ile Ile Gln Gln Thr Trp Asn Arg Thr Phe Glu Gly Ile 
385                 390                 395                 400 


Ala Gly Gln Val Ser Ile Asp Ala Asn Gly Asp Arg Tyr Gly Asp Phe 
                405                 410                 415     


Ser Val Ile Ala Met Thr Asp Val Glu Ala Gly Thr Gln Glu Val Ile 
            420                 425                 430         


Gly Asp Tyr Phe Gly Lys Glu Gly Arg Phe Glu Met Arg Pro Asn Val 
        435                 440                 445             


Lys Tyr Pro Trp Gly Pro Leu Lys Leu Arg Ile Asp Glu Asn Arg Ile 
    450                 455                 460                 


Val Glu His Thr Asn Ser Ser Pro Cys Lys Ser Cys Gly Leu Glu Glu 
465                 470                 475                 480 


Ser Ala Val Thr Gly Ile Val Val Gly Ala Leu Leu Gly Ala Gly Leu 
                485                 490                 495     


Leu Met Ala Phe Tyr Phe Phe Arg Lys Lys Tyr Arg Ile Thr Ile Glu 
            500                 505                 510         


Arg Arg Thr Gln Gln Glu Glu Ser Asn Leu Gly Lys His Arg Glu Leu 
        515                 520                 525             


Arg Glu Asp Ser Ile Arg Ser His Phe Ser Val Ala 
    530                 535                 540 


<210>  11
<211>  19
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthesized oligonucleotide primer

<400>  11
acttttaccg aatgccacc                                                    19


<210>  12
<211>  23
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthesized oligonucleotide primer

<400>  12
tggttactct caagtcaatc ttg                                               23


<210>  13
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthesized oligonucleotide primer

<400>  13
ccatcaagac catcaccatc                                                   20


<210>  14
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthesized oligonucleotide primer

<400>  14
gccgataaac aggtacacga                                                   20


<210>  15
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthesized oligonucleotide primer

<400>  15
cctgagatca aaaggtcctg                                                   20


<210>  16
<211>  19
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthesized oligonucleotide primer

<400>  16
cttcaaacat tgtggtggc                                                    19


<210>  17
<211>  23
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthesized oligonucleotide primer

<400>  17
gctacagata agaaaaccag tga                                               23


<210>  18
<211>  17
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthesized oligonucleotide primer

<400>  18
gctttccatt tcccgga                                                      17


<210>  19
<211>  18
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthesized oligonucleotide primer

<400>  19
tcggcagtga caggaatt                                                     18


<210>  20
<211>  18
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthesized oligonucleotide primer

<400>  20
cccgatgttt tccaaggt                                                     18


