                         SEQUENCE LISTING

<110>  University of Utah Research Foundation

       Yost, H. Joseph
       Parant, John M.
 
<120>  Identification of Tumor Suppressor Genes in Zebrafish and a Novel
        p53 Mutant as a Model for Cancer

<130>  21101.0232U1

<140>  Not Yet Assigned
<141>  2010-12-17

<160>  36    

<170>  PatentIn version 3.5

<210>  1
<211>  372
<212>  PRT
<213>  Danio rerio

<400>  1

Met Ala Gln Asn Asp Ser Gln Glu Phe Ala Glu Leu Trp Glu Lys Asn 
1               5                   10                  15      


Leu Ile Ile Gln Pro Pro Gly Gly Gly Ser Cys Trp Asp Ile Ile Asn 
            20                  25                  30          


Asp Glu Glu Tyr Leu Pro Gly Ser Phe Asp Pro Asn Phe Phe Glu Asn 
        35                  40                  45              


Val Leu Glu Glu Gln Pro Gln Pro Ser Thr Leu Pro Pro Thr Ser Thr 
    50                  55                  60                  


Val Pro Glu Thr Ser Asp Tyr Pro Gly Asp His Gly Phe Arg Leu Arg 
65                  70                  75                  80  


Phe Gln Ser Gly Thr Ala Lys Ser Val Thr Cys Thr Tyr Ser Pro Asp 
                85                  90                  95      


Leu Asn Lys Leu Phe Cys Gln Leu Ala Lys Thr Cys Pro Val Gln Met 
            100                 105                 110         


Val Val Asp Val Ala Pro Pro Gln Gly Ser Val Val Arg Ala Thr Ala 
        115                 120                 125             


Ile Tyr Lys Lys Ser Glu His Val Ala Glu Val Val Arg Arg Cys Pro 
    130                 135                 140                 


His His Glu Arg Thr Pro Asp Gly Asp Asn Leu Ala Pro Ala Gly His 
145                 150                 155                 160 


Leu Ile Arg Val Glu Gly Asn Gln Arg Ala Asn Tyr Arg Glu Asp Asn 
                165                 170                 175     


Ile Thr Leu Arg His Ser Val Phe Val Pro Tyr Glu Ala Pro Gln Leu 
            180                 185                 190         


Gly Ala Glu Trp Thr Thr Val Leu Leu Asn Tyr Met Cys Asn Ser Ser 
        195                 200                 205             


Cys Met Gly Gly Met Asn Arg Arg Pro Ile Leu Thr Ile Ile Thr Leu 
    210                 215                 220                 


Glu Thr Gln Glu Gly Gln Leu Leu Gly Arg Arg Ser Phe Glu Val Arg 
225                 230                 235                 240 


Val Cys Ala Cys Pro Gly Arg Asp Arg Lys Thr Glu Glu Ser Asn Phe 
                245                 250                 255     


Lys Lys Asp Gln Glu Thr Lys Thr Met Ala Lys Thr Thr Thr Gly Thr 
            260                 265                 270         


Lys Arg Ser Leu Val Lys Glu Ser Ser Ser Ala Thr Leu Arg Pro Glu 
        275                 280                 285             


Gly Ser Lys Lys Ala Lys Gly Ser Ser Ser Asp Glu Glu Ile Phe Thr 
    290                 295                 300                 


Leu Gln Val Arg Gly Arg Glu Arg Tyr Glu Ile Leu Lys Lys Leu Asn 
305                 310                 315                 320 


Asp Ser Leu Glu Leu Ser Asp Val Val Pro Ala Ser Asp Ala Glu Lys 
                325                 330                 335     


Tyr Arg Gln Lys Phe Met Thr Lys Asn Lys Lys Glu Asn Arg Glu Ser 
            340                 345                 350         


Ser Glu Pro Lys Gln Gly Lys Lys Leu Met Val Lys Asp Glu Gly Arg 
        355                 360                 365             


Ser Asp Ser Asp 
    370         


<210>  2
<211>  373
<212>  PRT
<213>  Danio rerio

<400>  2

Met Ala Gln Asn Asp Ser Gln Glu Phe Ala Glu Leu Trp Glu Lys Asn 
1               5                   10                  15      


Leu Ile Ile Gln Pro Pro Gly Gly Gly Ser Cys Trp Asp Ile Ile Asn 
            20                  25                  30          


Asp Glu Glu Tyr Leu Pro Gly Ser Phe Asp Pro Asn Phe Phe Glu Asn 
        35                  40                  45              


Val Leu Glu Glu Gln Pro Gln Pro Ser Thr Leu Pro Pro Thr Ser Thr 
    50                  55                  60                  


Val Pro Glu Thr Ser Asp Tyr Pro Gly Asp His Gly Phe Arg Leu Arg 
65                  70                  75                  80  


Phe Pro Gln Ser Gly Thr Ala Lys Ser Val Thr Cys Thr Tyr Ser Pro 
                85                  90                  95      


Asp Leu Asn Lys Leu Phe Cys Gln Leu Ala Lys Thr Cys Pro Val Gln 
            100                 105                 110         


Met Val Val Asp Val Ala Pro Pro Gln Gly Ser Val Val Arg Ala Thr 
        115                 120                 125             


Ala Ile Tyr Lys Lys Ser Glu His Val Ala Glu Val Val Arg Arg Cys 
    130                 135                 140                 


Pro His His Glu Arg Thr Pro Asp Gly Asp Asn Leu Ala Pro Ala Gly 
145                 150                 155                 160 


His Leu Thr Arg Val Glu Gly Asn Gln Arg Ala Asn Tyr Arg Glu Asp 
                165                 170                 175     


Asn Ile Thr Leu Arg His Ser Val Phe Val Pro Tyr Glu Ala Pro Gln 
            180                 185                 190         


Leu Gly Ala Glu Trp Thr Thr Val Leu Leu Asn Tyr Met Cys Asn Ser 
        195                 200                 205             


Ser Cys Met Gly Gly Met Asn Arg Arg Pro Ile Leu Thr Ile Ile Thr 
    210                 215                 220                 


Leu Glu Thr Gln Glu Gly Gln Leu Leu Gly Arg Arg Ser Phe Glu Val 
225                 230                 235                 240 


Arg Val Cys Ala Cys Pro Gly Arg Asp Arg Lys Thr Glu Glu Ser Asn 
                245                 250                 255     


Phe Lys Lys Asp Gln Glu Thr Lys Thr Met Ala Lys Thr Thr Thr Gly 
            260                 265                 270         


Thr Lys Arg Ser Leu Val Lys Glu Ser Ser Ser Ala Thr Leu Arg Pro 
        275                 280                 285             


Glu Gly Ser Lys Lys Ala Lys Gly Ser Ser Ser Asp Glu Glu Ile Phe 
    290                 295                 300                 


Thr Leu Gln Val Arg Gly Arg Glu Arg Tyr Glu Ile Leu Lys Lys Leu 
305                 310                 315                 320 


Asn Asp Ser Leu Glu Leu Ser Asp Val Val Pro Ala Ser Asp Ala Glu 
                325                 330                 335     


Lys Tyr Arg Gln Lys Phe Met Thr Lys Asn Lys Lys Glu Asn Arg Glu 
            340                 345                 350         


Ser Ser Glu Pro Lys Gln Gly Lys Lys Leu Met Val Lys Asp Glu Gly 
        355                 360                 365             


Arg Ser Asp Ser Asp 
    370             


<210>  3
<211>  16
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Note = Synthetic Construct

<400>  3
atggcggcgc acaagc                                                       16


<210>  4
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Note = Synthetic Construct

<400>  4
cactagacgc ttcttggc                                                     18


<210>  5
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Note = Synthetic Construct

<400>  5
ccaccatgat tgaccaggtg acc                                               23


<210>  6
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Note = Synthetic Construct

<400>  6
tcttaacaag catattcagg                                                   20


<210>  7
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Note = Synthetic Construct

<400>  7
cccttgcgaa cttacatcaa attct                                             25


<210>  8
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Note = Synthetic Construct

<400>  8
tgttaagaga ttcagtacgc accgc                                             25


<210>  9
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Note = Synthetic Construct

<400>  9
accatggcta acgaaatt                                                     18


<210>  10
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Note = Synthetic Construct

<400>  10
cgcagaggct gtcacttc                                                     18


<210>  11
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Note = Synthetic Construct

<400>  11
ccaaaatggc aacagaga                                                     18


<210>  12
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Note = Synthetic Construct

<400>  12
atttcagtgc ctcagctc                                                     18


<210>  13
<211>  16
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: note = Synthetic Construct

<400>  13
atggcgcaaa acgaca                                                       16


<210>  14
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Note = Synthetic Construct

<400>  14
tagcatccca tcacctta                                                     18


<210>  15
<211>  14
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Note = Synthetic Construct

<400>  15
gcgcctgctg gtca                                                         14


<210>  16
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Note = Synthetic Construct

<400>  16
ctgattgccc tccactctt                                                    19


<210>  17
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Note = Synthetic Construct

<400>  17
tgacatcagc gggtttacag                                                   20


<210>  18
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Note = Synthetic Construct

<400>  18
ttctctgctt ttcctgaca                                                    19


<210>  19
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Note = Synthetic Construct

<400>  19
ccaccatgat tgaccaggtg acc                                               23


<210>  20
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Note = Synthetic Construct

<400>  20
agcagcacag acccacac                                                     18


<210>  21
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Note = Synthetic Construct

<400>  21
ctcggtgctg ttcttggagt                                                   20


<210>  22
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Note = Synthetic Construct

<400>  22
cactgcttct cctcctcctg                                                   20


<210>  23
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Note = Synthetic Construct

<400>  23
acagggatgc tgaagtgacc                                                   20


<210>  24
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Note = Synthetic Construct

<400>  24
gaaaagcgcc acaactcttc                                                   20


<210>  25
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Note = Synthetic Construct

<400>  25
acgctgtctt ccttcagagg                                                   20


<210>  26
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Note = Synthetic Construct

<400>  26
cctgcagaaa attcccagag                                                   20


<210>  27
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Note = Synthetic Construct

<400>  27
atggcgaaga aagagcaaac                                                   20


<210>  28
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Note = Synthetic Construct

<400>  28
cgcttcccct ccatttgtat                                                   20


<210>  29
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Note = Synthetic Construct

<400>  29
accccggatg gagataactt                                                   20


<210>  30
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Note = Synthetic Construct

<400>  30
cccagcaact gaccttcctg ag                                                22


<210>  31
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Note = Synthetic Construct

<400>  31
ggtatgggac agaaagacag                                                   20


<210>  32
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Note = Synthetic Construct

<400>  32
agagtccatc acgataccag                                                   20


<210>  33
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Note = Synthetic Construct

<400>  33
gtgctgttaa agccaccaca                                                   20


<210>  34
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Note = Synthetic Construct

<400>  34
ggtcctacaa aaaggctgtg a                                                 21


<210>  35
<211>  1110
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Note = Synthetic Construct

<400>  35
atggcgcaaa acgacagcca agagttcgcg gagctctggg agaagaattt gattattcag       60

cccccaggtg gtggctcttg ctgggacatc attaatgatg aggagtactt gccgggatcg      120

tttgacccca atttttttga aaatgtgctt gaagaacagc ctcagccatc cactctccca      180

ccaacatcca ctgttccgga gacaagcgac tatcccggcg atcatggatt taggctcagg      240

ttcccgcagt ctggcacagc aaaatctgta acttgcactt attcaccgga cctgaataaa      300

ctcttctgtc agctggcaaa aacttgcccc gttcaaatgg tggtggacgt tgcccctcca      360

cagggctccg tggttcgagc cactgccatc tataagaagt ccgagcatgt ggccgaagtg      420

gtccgcagat gcccccatca tgagcgaacc ccggatggag ataacttggc gcctgctggc      480

catttgataa gagtggaggg caatcagcga gcaaattaca gggaagataa catcacttta      540

aggcatagtg tttttgtccc atatgaagca ccacagcttg gtgctgaatg gacaactgtg      600

ctactaaact acatgtgcaa tagcagctgc atggggggga tgaaccgcag gcccatcctc      660

acaatcatca ctctggagac tcaggaaggt cagttgctgg gccggaggtc ttttgaggtg      720

cgtgtgtgtg catgtccagg cagagacagg aaaactgagg agagcaactt caagaaagac      780

caagagacca aaaccatggc caaaaccacc actgggacca aacgtaaatc ttcttcagct      840

acatcacgac ctgaggggag caaaaaggcc aagggctcca gcagcgatga ggagatcttt      900

accctgcagg tgaggggccg ggagcgttat gaaattttaa agaaattgaa cgacagtctg      960

gagttaagtg atgtggtgcc tgcctcagat gctgaaaagt atcgtcagaa attcatgaca     1020

aaaaacaaaa aagagaatcg tgaatcatct gagcccaaac agggaaagaa gctgatggtg     1080

aaggacgaag gaagaagcga ctctgattaa                                      1110


<210>  36
<211>  1110
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Note = Synthetic Construct

<400>  36
atggcgcaaa acgacagcca agagttcgcg gagctctggg agaagaattt gattattcag       60

cccccaggtg gtggctcttg ctgggacatc attaatgatg aggagtactt gccgggatcg      120

tttgacccca atttttttga aaatgtgctt gaagaacagc ctcagccatc cactctccca      180

ccaacatcca ctgttccgga gacaagcgac tatcccggcg atcatggatt taggctcagg      240

ttcccgcagt ctggcacagc aaaatctgta acttgcactt attcaccgga cctgaataaa      300

ctcttctgtc agctggcaaa aacttgcccc gttcaaatgg tggtggacgt tgcccctcca      360

cagggctccg tggttcgagc cactgccatc tataagaagt ccgagcatgt ggccgaagtg      420

gtccgcagat gcccccatca tgagcgaacc ccggatggag ataacttggc gcctgctggc      480

catttgacaa gagtggaggg caatcagcga gcaaattaca gggaagataa catcacttta      540

aggcatagtg tttttgtccc atatgaagca ccacagcttg gtgctgaatg gacaactgtg      600

ctactaaact acatgtgcaa tagcagctgc atggggggga tgaaccgcag gcccatcctc      660

acaatcatca ctctggagac tcaggaaggt cagttgctgg gccggaggtc ttttgaggtg      720

cgtgtgtgtg catgtccagg cagagacagg aaaactgagg agagcaactt caagaaagac      780

caagagacca aaaccatggc caaaaccacc actgggacca aacgtaaatc ttcttcagct      840

acatcacgac ctgaggggag caaaaaggcc aagggctcca gcagcgatga ggagatcttt      900

accctgcagg tgaggggccg ggagcgttat gaaattttaa agaaattgaa cgacagtctg      960

gagttaagtg atgtggtgcc tgcctcagat gctgaaaagt atcgtcagaa attcatgaca     1020

aaaaacaaaa aagagaatcg tgaatcatct gagcccaaac agggaaagaa gctgatggtg     1080

aaggacgaag gaagaagcga ctctgattaa                                      1110


