                         SEQUENCE LISTING

<110>  DiMarchi, Richard
 
<120>  Glucagon/GLP-1 receptor co-agonists

<130>  31135/45098

<160>  188   

<170>  PatentIn version 3.5

<210>  1
<211>  158
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<223>  Pre-proglucagon

<220>
<221>  MISC_FEATURE
<223>  Pre-proglucagon

<400>  1

Arg Ser Leu Gln Asp Thr Glu Glu Lys Ser Arg Ser Phe Ser Ala Ser 
1               5                   10                  15      


Gln Ala Asp Pro Leu Ser Asp Pro Asp Gln Met Asn Glu Asp Lys Arg 
            20                  25                  30          


His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Ser 
        35                  40                  45              


Arg Arg Ala Gln Asp Phe Val Gln Trp Leu Met Asn Thr Lys Arg Asn 
    50                  55                  60                  


Arg Asn Asn Ile Ala Lys Arg His Asp Glu Phe Glu Arg His Ala Glu 
65                  70                  75                  80  


Gly Thr Phe Thr Ser Asp Val Ser Ser Tyr Leu Glu Gly Gln Ala Ala 
                85                  90                  95      


Lys Glu Phe Ile Ala Trp Leu Val Lys Gly Arg Gly Arg Arg Asp Phe 
            100                 105                 110         


Pro Glu Glu Val Ala Ile Val Glu Glu Leu Gly Arg Arg His Ala Asp 
        115                 120                 125             


Gly Ser Phe Ser Asp Glu Met Asn Thr Ile Leu Asp Asn Leu Ala Ala 
    130                 135                 140                 


Arg Asp Phe Ile Asn Trp Leu Ile Gln Thr Lys Ile Thr Asp 
145                 150                 155             


<210>  2
<211>  29
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<223>  Native human glucagon

<400>  2

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Ser 
1               5                   10                  15      


Arg Arg Ala Gln Asp Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  


<210>  3
<211>  37
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<223>  GLP-1

<400>  3

His Asp Glu Phe Glu Arg His Ala Glu Gly Thr Phe Thr Ser Asp Val 
1               5                   10                  15      


Ser Ser Tyr Leu Glu Gly Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu 
            20                  25                  30          


Val Lys Gly Arg Gly 
        35          


<210>  4
<211>  33
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<223>  GLP-2

<400>  4

His Ala Asp Gly Ser Phe Ser Asp Glu Met Asn Thr Ile Leu Asp Asn 
1               5                   10                  15      


Leu Ala Ala Arg Asp Phe Ile Asn Trp Leu Ile Gln Thr Lys Ile Thr 
            20                  25                  30          


Asp 
    


<210>  5
<211>  37
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<223>  Oxyntomodulin

<400>  5

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Ser 
1               5                   10                  15      


Arg Arg Ala Gln Asp Phe Val Gln Trp Leu Met Asp Thr Lys Arg Asn 
            20                  25                  30          


Arg Asn Asn Ile Ala 
        35          


<210>  6
<211>  30
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<223>  GLP1 (7-36 amide)

<220>
<221>  MOD_RES
<222>  (30)..(30)
<223>  C-terminal amidation

<400>  6

His Ala Glu Gly Thr Phe Thr Ser Asp Val Ser Ser Tyr Leu Glu Gly 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Val Lys Gly Arg 
            20                  25                  30  


<210>  7
<211>  31
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<223>  GLP-1 (7-37 acid)

<400>  7

His Ala Glu Gly Thr Phe Thr Ser Asp Val Ser Ser Tyr Leu Glu Gly 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Val Lys Gly Arg Gly 
            20                  25                  30      


<210>  8
<211>  39
<212>  PRT
<213>  Heloderma suspectum


<220>
<221>  MISC_FEATURE
<223>  Exendin-4

<400>  8

His Gly Glu Gly Thr Phe Thr Ser Asp Leu Ser Lys Gln Met Glu Glu 
1               5                   10                  15      


Glu Ala Val Arg Leu Phe Ile Glu Trp Leu Lys Asn Gly Gly Pro Ser 
            20                  25                  30          


Ser Gly Ala Pro Pro Pro Ser 
        35                  


<210>  9
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is Aib

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  Acylated with a C16 fatty acyl group via gamma-Glu-gamma-Glu 
       spacer

<220>
<221>  MOD_RES
<222>  (16)..(16)
<223>  Xaa is Aib

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  9

His Xaa Gln Gly Thr Phe Thr Ser Asp Lys Ser Lys Tyr Leu Asp Xaa 
1               5                   10                  15      


Arg Ala Ala Gln Asp Phe Val Gln Trp Leu Met Asp Thr 
            20                  25                  


<210>  10
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is Aib

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  Acylated with a C16 fatty acyl group via gamma-Glu spacer

<220>
<221>  MOD_RES
<222>  (16)..(16)
<223>  Xaa is Aib

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  10

His Xaa Gln Gly Thr Phe Thr Ser Asp Lys Ser Lys Tyr Leu Asp Xaa 
1               5                   10                  15      


Arg Ala Ala Gln Asp Phe Val Gln Trp Leu Met Asp Thr 
            20                  25                  


<210>  11
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MOD_RES
<222>  (7)..(7)
<223>  Xaa is Glu or Cys

<400>  11

Ala Val Arg Leu Phe Ile Xaa 
1               5           


<210>  12
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is Glu, Lys, or Gln

<220>
<221>  MOD_RES
<222>  (9)..(9)
<223>  Xaa is Glu or Cys

<400>  12

Glu Xaa Ala Val Arg Leu Phe Ile Xaa 
1               5                   


<210>  13
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide

<400>  13

Lys Arg Asn Arg Asn Asn Ile Ala 
1               5               


<210>  14
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide

<400>  14

Gly Pro Ser Ser Gly Ala Pro Pro Pro Ser 
1               5                   10  


<210>  15
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide

<400>  15

Gly Gly Pro Ser Ser Gly Ala Pro Pro Pro Ser 
1               5                   10      


<210>  16
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide

<400>  16

Lys Arg Asn Arg 
1               


<210>  17
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is Aib

<220>
<221>  MOD_RES
<222>  (16)..(16)
<223>  Xaa is an alpha-methylated amino acid bearing an olefinic side 
       chain

<220>
<221>  MOD_RES
<222>  (20)..(20)
<223>  Xaa is an alpha-methylated amino acid bearing an olefinic side 
       chain

<400>  17

His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Xaa 
1               5                   10                  15      


Gln Ala Ala Xaa Glu Phe Ile Ala Trp Leu Met Asn Thr 
            20                  25                  


<210>  18
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  Peptide 1

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  18

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Ser 
1               5                   10                  15      


Lys Arg Ala Gln Glu Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  


<210>  19
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  Peptide 2

<220>
<221>  MISC_FEATURE
<222>  (17)..(21)
<223>  Lactam ring between side chains of amino acids

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  19

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Ser 
1               5                   10                  15      


Lys Arg Ala Gln Glu Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  


<210>  20
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  Peptide 3

<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  Lactam ring between side chains of amino acids

<400>  20

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Lys 
1               5                   10                  15      


Arg Arg Ala Glu Asp Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  


<210>  21
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  Peptide 4

<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  Lactam ring between side chains of amino acids

<220>
<221>  MOD_RES
<222>  (20)..(20)
<223>  Xaa is Ornithine

<400>  21

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Xaa Asp Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  


<210>  22
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  Peptide 5

<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  Lactam ring between side chains of amino acids

<220>
<221>  MOD_RES
<222>  (20)..(20)
<223>  Xaa is diaminobutanoic acid

<400>  22

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Xaa Asp Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  


<210>  23
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  Peptide 6

<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  Lactam ring between side chains of amino acids

<220>
<221>  MOD_RES
<222>  (20)..(20)
<223>  Xaa is Ornithine

<400>  23

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Xaa Asp Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  


<210>  24
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  Peptide 7

<220>
<221>  MOD_RES
<222>  (20)..(20)
<223>  Xaa is Ornithine

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  24

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Xaa Asp Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  


<210>  25
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  Peptide 8

<220>
<221>  MOD_RES
<222>  (21)..(21)
<223>  Xaa is Ornithine

<400>  25

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Asp 
1               5                   10                  15      


Arg Arg Ala Gln Xaa Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  


<210>  26
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  Peptide 9

<220>
<221>  MOD_RES
<222>  (20)..(20)
<223>  Xaa is Ornithine

<400>  26

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Ser 
1               5                   10                  15      


Asp Arg Ala Xaa Asp Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  


<210>  27
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  Peptide 10

<220>
<221>  MISC_FEATURE
<222>  (17)..(20)
<223>  Lactam ring between side chains of amino acids

<220>
<221>  MOD_RES
<222>  (20)..(20)
<223>  Xaa is Ornithine

<400>  27

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Ser 
1               5                   10                  15      


Asp Arg Ala Xaa Asp Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  


<210>  28
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  Peptide 11

<220>
<221>  MISC_FEATURE
<222>  (17)..(20)
<223>  Lactam ring between side chains of amino acids

<220>
<221>  MOD_RES
<222>  (20)..(20)
<223>  Xaa is Ornithine

<400>  28

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Ser 
1               5                   10                  15      


Glu Arg Ala Xaa Asp Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  


<210>  29
<211>  31
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  Peptide 12

<220>
<221>  MOD_RES
<222>  (31)..(31)
<223>  C-terminal amidation

<400>  29

Lys Ala His Ser Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu 
1               5                   10                  15      


Asp Ser Arg Arg Ala Gln Asp Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  30      


<210>  30
<211>  31
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  Peptide 13

<220>
<221>  MISC_FEATURE
<222>  (1)..(5)
<223>  Lactam ring between side chains of amino acids

<220>
<221>  MOD_RES
<222>  (31)..(31)
<223>  C-terminal amidation

<400>  30

Lys Ala His Ser Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu 
1               5                   10                  15      


Asp Ser Arg Arg Ala Gln Asp Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  30      


<210>  31
<211>  30
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  Peptide 14

<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  D-Lys

<220>
<221>  MOD_RES
<222>  (5)..(5)
<223>  D-Glu

<220>
<221>  MOD_RES
<222>  (30)..(30)
<223>  C-terminal amidation

<400>  31

Lys His Ser Gln Glu Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp 
1               5                   10                  15      


Ser Arg Arg Ala Gln Asp Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  30  


<210>  32
<211>  30
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  Peptide 15

<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  D-Lys

<220>
<221>  MISC_FEATURE
<222>  (1)..(5)
<223>  Lactam ring between side chains of amino acids

<220>
<221>  MOD_RES
<222>  (5)..(5)
<223>  D-Glu

<220>
<221>  MOD_RES
<222>  (30)..(30)
<223>  C-terminal amidation

<400>  32

Lys His Ser Gln Glu Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp 
1               5                   10                  15      


Ser Arg Arg Ala Gln Asp Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  30  


<210>  33
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  Peptide 16

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  33

His Ser Gln Lys Thr Phe Thr Glu Asp Tyr Ser Lys Tyr Leu Asp Ser 
1               5                   10                  15      


Arg Arg Ala Gln Asp Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  


<210>  34
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  Peptide 17

<220>
<221>  MISC_FEATURE
<222>  (4)..(8)
<223>  Lactam ring between side chains of amino acids

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  34

His Ser Gln Lys Thr Phe Thr Glu Asp Tyr Ser Lys Tyr Leu Asp Ser 
1               5                   10                  15      


Arg Arg Ala Gln Asp Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  


<210>  35
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  Peptide 18

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  35

His Ser Gln Gly Thr Phe Thr Glu Asp Tyr Ser Lys Tyr Leu Asp Ser 
1               5                   10                  15      


Arg Arg Ala Gln Asp Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  


<210>  36
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  Peptide 19

<220>
<221>  MISC_FEATURE
<222>  (8)..(12)
<223>  Lactam ring between side chains of amino acids

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  36

His Ser Gln Gly Thr Phe Thr Glu Asp Tyr Ser Lys Tyr Leu Asp Ser 
1               5                   10                  15      


Arg Arg Ala Gln Asp Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  


<210>  37
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  Glucagon Analog 20

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  d-Ser

<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  Salt bridge

<220>
<221>  MISC_FEATURE
<222>  (17)..(21)
<223>  Salt bridge

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  37

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Lys Arg Ala Lys Glu Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  


<210>  38
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  Glucagon Analog 21

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  D-Ser

<220>
<221>  MOD_RES
<222>  (16)..(16)
<223>  Xaa is AIB

<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  Salt bridge

<220>
<221>  MISC_FEATURE
<222>  (17)..(21)
<223>  Salt bridge

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  38

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Xaa 
1               5                   10                  15      


Lys Arg Ala Lys Glu Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  


<210>  39
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  Glucagon Analog 22

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  D-Ser

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  Acylated with C16 fatty acyl group via gamma-Glu spacer

<220>
<221>  MISC_FEATURE
<222>  (15)..(20)
<223>  Salt bridge

<220>
<221>  MOD_RES
<222>  (16)..(16)
<223>  Xaa is AIB

<220>
<221>  MISC_FEATURE
<222>  (16)..(21)
<223>  Salt bridge

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  39

His Ser Gln Gly Thr Phe Thr Ser Asp Lys Ser Lys Tyr Leu Asp Xaa 
1               5                   10                  15      


Lys Arg Ala Lys Glu Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  


<210>  40
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  Glucagon Analog 23

<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Xaa is alpha, alpha-dimethyl imidiazole acetic acid

<220>
<221>  MISC_FEATURE
<222>  (24)..(24)
<223>  Covalently bound to 40kDa PEG

<400>  40

Xaa Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Lys Asp Phe Val Cys Trp Leu Met Asn Thr 
            20                  25                  


<210>  41
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  Glucagon Analog 24

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  d-Ser

<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  Salt bridge

<220>
<221>  MISC_FEATURE
<222>  (17)..(21)
<223>  Salt bridge

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Covalently bound to 40kDa PEG

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  41

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Lys Arg Ala Lys Glu Phe Val Cys Trp Leu Met Asn Thr 
            20                  25                  


<210>  42
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  Glucagon Analog 25

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is AIB

<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  Salt bridge

<220>
<221>  MISC_FEATURE
<222>  (17)..(21)
<223>  Salt bridge

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Covalently bound to a 40kDa PEG

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  42

His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Lys Arg Ala Lys Glu Phe Val Cys Trp Leu Met Asn Thr 
            20                  25                  


<210>  43
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  Glucagon Analog 26

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  d-Ser

<220>
<221>  MOD_RES
<222>  (16)..(16)
<223>  Xaa is AIB

<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  Salt bridge

<220>
<221>  MISC_FEATURE
<222>  (17)..(21)
<223>  Salt bridge

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Covalently bound to 40kDa PEG

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  43

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Xaa 
1               5                   10                  15      


Lys Arg Ala Lys Glu Phe Val Cys Trp Leu Met Asn Thr 
            20                  25                  


<210>  44
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  Glucagon Analog 27

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is AIB

<220>
<221>  MOD_RES
<222>  (16)..(16)
<223>  Xaa is AIB

<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  Salt bridge

<220>
<221>  MISC_FEATURE
<222>  (17)..(21)
<223>  Salt bridge

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Covalently bound to 40kDa PEG

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  44

His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Xaa 
1               5                   10                  15      


Lys Arg Ala Lys Glu Phe Val Cys Trp Leu Met Asn Thr 
            20                  25                  


<210>  45
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  Glucagon Analog 28

<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Xaa is DMIA

<220>
<221>  MOD_RES
<222>  (16)..(16)
<223>  Xaa is AIB

<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  Salt bridge

<220>
<221>  MISC_FEATURE
<222>  (17)..(21)
<223>  Salt bridge

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  PEGYLATION

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  45

Xaa Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Xaa 
1               5                   10                  15      


Lys Arg Ala Lys Glu Phe Val Cys Trp Leu Met Asn Thr 
            20                  25                  


<210>  46
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  Glucagon Analog 29

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  d-Ser

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  Acylated with C16 fatty acyl group via gamma-Glu spacer

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Covalently bound to 40kDa PEG

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  46

His Ser Gln Gly Thr Phe Thr Ser Asp Lys Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Ala Ala Gln Asp Phe Val Cys Trp Leu Leu Asp Thr 
            20                  25                  


<210>  47
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  Glucagon Analog 30

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is AIB

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  Acylated with C16 fatty acyl group via gamma-Glu spacer

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Covalently bound to 40kDa PEG

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  47

His Xaa Gln Gly Thr Phe Thr Ser Asp Lys Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Cys Trp Leu Leu Asp Thr 
            20                  25                  


<210>  48
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  Glucagon Analog 31

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  d-Ser

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  48

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Glu Ala Val Arg Leu Phe Ile Glu Trp Leu Met Asn Thr 
            20                  25                  


<210>  49
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  Glucagon Analog 32

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is AIB

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  49

His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Glu Ala Val Arg Leu Phe Ile Glu Trp Leu Met Asn Thr 
            20                  25                  


<210>  50
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  Glucagon Analog 33

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  d-Ser

<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  Salt bridge

<220>
<221>  MISC_FEATURE
<222>  (17)..(21)
<223>  Salt bridge

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  50

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Glu Ala Val Arg Leu Phe Ile Cys Trp Leu Met Asn Thr 
            20                  25                  


<210>  51
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  Glucagon Analog 34

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is AIB

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  51

His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Glu Ala Val Arg Leu Phe Ile Cys Trp Leu Met Asn Thr 
            20                  25                  


<210>  52
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  Glucagon Analog 35

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  d-Ser

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Covalently bound to 40kDa PEG

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  52

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Glu Ala Val Arg Leu Phe Ile Cys Trp Leu Met Asn Thr 
            20                  25                  


<210>  53
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  Glucagon Analog 36

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is AIB

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Covalently bound to 40kDa PEG

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  53

His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Glu Ala Val Arg Leu Phe Ile Cys Trp Leu Met Asn Thr 
            20                  25                  


<210>  54
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  Glucagon Analog 37

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  Acylated with C16 fatty acyl group via gamma-Glu spacer

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  54

His Ser Gln Gly Thr Phe Thr Ser Asp Lys Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Glu Ala Val Arg Leu Phe Ile Glu Trp Leu Met Asn Thr 
            20                  25                  


<210>  55
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  Glucagon Analog 38

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is AIB

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  Acylated with C16 fatty acyl group via gamma-Glu spacer

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  55

His Xaa Gln Gly Thr Phe Thr Ser Asp Lys Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Glu Ala Val Arg Leu Phe Ile Glu Trp Leu Met Asn Thr 
            20                  25                  


<210>  56
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  Glucagon Analog 39

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  Acylated with C16 fatty acyl group

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  56

His Ser Gln Gly Thr Phe Thr Ser Asp Lys Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Glu Ala Val Arg Leu Phe Ile Glu Trp Leu Met Asn Thr 
            20                  25                  


<210>  57
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  Glucagon Analog 40

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is AIB

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  Acylated with C16 fatty acyl group

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  57

His Xaa Gln Gly Thr Phe Thr Ser Asp Lys Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Glu Ala Val Arg Leu Phe Ile Glu Trp Leu Met Asn Thr 
            20                  25                  


<210>  58
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  Glucagon Analog 42

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is Aminoisobutyric acid

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  Acylated with a C16 fatty acyl group via gamma-Glu-gamma-Glu 
       spacer

<220>
<221>  MOD_RES
<222>  (16)..(16)
<223>  Xaa is AIB

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  58

His Xaa Gln Gly Thr Phe Thr Ser Asp Lys Ser Lys Tyr Leu Asp Xaa 
1               5                   10                  15      


Arg Ala Ala Gln Asp Phe Val Gln Trp Leu Met Asp Thr 
            20                  25                  


<210>  59
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  Glucagon Analog 43

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is Aminoisobutyric acid

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  Acylated with a C16 fatty acyl group via gamma-Glu spacer

<220>
<221>  MOD_RES
<222>  (16)..(16)
<223>  Xaa is Aminoisobutyric acid

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  59

His Xaa Gln Gly Thr Phe Thr Ser Asp Lys Ser Lys Tyr Leu Asp Xaa 
1               5                   10                  15      


Arg Ala Ala Gln Asp Phe Val Gln Trp Leu Met Asp Thr 
            20                  25                  


<210>  60
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  Glucagon Analog 44

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  D-Ser

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  Acylated with C16 fatty acyl group via gamma-Glu-gamma-Glu spacer

<220>
<221>  MOD_RES
<222>  (16)..(16)
<223>  Xaa is AIB

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  60

His Ser Gln Gly Thr Phe Thr Ser Asp Lys Ser Lys Tyr Leu Glu Xaa 
1               5                   10                  15      


Arg Ala Ala Gln Asp Phe Val Gln Trp Leu Met Asp Thr 
            20                  25                  


<210>  61
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  Glucagon Analog 45

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is AIB

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  Acylated with C16 fatty acyl group via gamma-Glu-gamma-Glu spacer

<220>
<221>  MOD_RES
<222>  (16)..(16)
<223>  Xaa is AIB

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  61

His Xaa Glu Gly Thr Phe Thr Ser Asp Lys Ser Lys Tyr Leu Asp Xaa 
1               5                   10                  15      


Arg Ala Ala Gln Asp Phe Val Gln Trp Leu Met Asp Thr 
            20                  25                  


<210>  62
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  Glucagon Analog 46

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is AIB

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  Acylated with C16 fatty acyl group via gamma-Glu-gamma-Glu spacer

<220>
<221>  MOD_RES
<222>  (16)..(16)
<223>  Xaa is AIB

<400>  62

His Xaa Gln Gly Thr Phe Ile Ser Asp Lys Ser Lys Tyr Leu Asp Xaa 
1               5                   10                  15      


Arg Ala Ala Gln Asp Phe Val Gln Trp Leu Met Asp Thr 
            20                  25                  


<210>  63
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  Glucagon Analog 48

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is AIB

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  Acylated with C16 fatty acyl group via gamma-Glu-gamma-Glu spacer

<220>
<221>  MOD_RES
<222>  (16)..(16)
<223>  Xaa is AIB

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  63

His Xaa Gln Gly Thr Phe Thr Ser Asp Lys Ser Lys Tyr Leu Glu Xaa 
1               5                   10                  15      


Arg Ala Ala Gln Asp Phe Val Gln Trp Leu Met Asp Thr 
            20                  25                  


<210>  64
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  Glucagon Analog 49

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is AIB

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  Acylated with C16 fatty acyl group via gamma-Glu-gamma-Glu spacer

<220>
<221>  MOD_RES
<222>  (16)..(16)
<223>  Xaa is AIB

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  64

His Xaa Gln Gly Thr Phe Thr Ser Asp Lys Ser Lys Tyr Leu Asp Xaa 
1               5                   10                  15      


Arg Ala Ala Gln Asp Phe Val Gln Trp Leu Leu Asp Thr 
            20                  25                  


<210>  65
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  Glucagon Analog 50

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is AIB

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  Acylated with C16 fatty acyl group via gamma-Glu-gamma-Glu spacer

<400>  65

His Xaa Gln Gly Thr Phe Thr Ser Asp Lys Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Ala Ala Gln Asp Phe Val Gln Trp Leu Met Asp Thr 
            20                  25                  


<210>  66
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  Glucagon Analog 51

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  d-Ser

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  Acylated with C16 fatty acyl group via gamma-Glu spacer

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  66

His Ser Gln Gly Thr Phe Thr Ser Asp Lys Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Ala Ala Gln Asp Phe Val Gln Trp Leu Leu Asp Thr 
            20                  25                  


<210>  67
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  Glucagon Analog 52

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is AIB

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  Acylated with C16 fatty acyl group via gamma-Glu spacer

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  67

His Xaa Gln Gly Thr Phe Thr Ser Asp Lys Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Leu Asp Thr 
            20                  25                  


<210>  68
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  Peptide 53

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  D-Ser

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  Acylated with C16 fatty acyl group via gamma-Glu spacer

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  PEGYLATION

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  68

His Ser Gln Gly Thr Phe Thr Ser Asp Lys Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Cys Trp Leu Leu Asp Thr 
            20                  25                  


<210>  69
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  Glucagon Analog 54

<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Xaa is DMIA

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  Acylated with C16 fatty acyl group via gamma-Glu spacer

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  69

Xaa Ser Gln Gly Thr Phe Thr Ser Asp Lys Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Cys Trp Leu Leu Asp Thr 
            20                  25                  


<210>  70
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  Glucagon Analog 57

<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Ac-His

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  Acylated with C16 fatty acyl group via gamma-Glu spacer

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  70

His Ser Gln Gly Thr Phe Thr Ser Asp Lys Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Cys Trp Leu Leu Asp Thr 
            20                  25                  


<210>  71
<211>  30
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  Glucagon Analog 55

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  d-Ser

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  Acylated with C16 fatty acyl group via gamma-Glu spacer

<400>  71

His Ser Gln Gly Thr Phe Thr Ser Asp Lys Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Cys Trp Leu Leu Asp Thr Gly 
            20                  25                  30  


<210>  72
<211>  31
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  Glucagon Analog 56

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  d-Ser

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  Acylated with C16 fatty acyl group via gamma-Glu spacer

<400>  72

His Ser Gln Gly Thr Phe Thr Ser Asp Lys Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Cys Trp Leu Leu Asp Thr Gly Gly 
            20                  25                  30      


<210>  73
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  Glucagon Analog 58

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is AIB

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  Acylated with C16 fatty acyl group via gamma-Glu spacer

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  73

His Xaa Gln Gly Thr Phe Thr Ser Asp Lys Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Ala Ala Gln Asp Phe Val Cys Trp Leu Leu Asp Thr 
            20                  25                  


<210>  74
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  Glucagon Analog 59

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  D-Ala

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  Acylated with C16 fatty acyl group via gamma-Glu spacer

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  74

His Ala Gln Gly Thr Phe Thr Ser Asp Lys Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Ala Ala Gln Asp Phe Val Cys Trp Leu Leu Asp Thr 
            20                  25                  


<210>  75
<211>  39
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  Glucagon Analog 60

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  D-Ser

<220>
<221>  MOD_RES
<222>  (16)..(16)
<223>  Xaa is AIB

<220>
<221>  MOD_RES
<222>  (39)..(39)
<223>  C-terminal amidation

<400>  75

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Xaa 
1               5                   10                  15      


Lys Arg Ala Lys Glu Phe Val Cys Trp Leu Leu Asp Gly Gly Pro Ser 
            20                  25                  30          


Ser Gly Ala Pro Pro Pro Ser 
        35                  


<210>  76
<211>  39
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  Glucagon Analog 61

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  D-Ser

<220>
<221>  MOD_RES
<222>  (39)..(39)
<223>  C-terminal amidation

<400>  76

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Lys Arg Ala Lys Glu Phe Val Cys Trp Leu Leu Asp Gly Gly Pro Ser 
            20                  25                  30          


Ser Gly Ala Pro Pro Pro Ser 
        35                  


<210>  77
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  Glucagon Analog 62

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  D-Ser

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  Acylated with a C16 fatty acyl group via gamma-Glu spacer

<220>
<221>  MOD_RES
<222>  (16)..(16)
<223>  Xaa is AIB

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  77

His Ser Gln Gly Thr Phe Thr Ser Asp Lys Ser Lys Tyr Leu Asp Xaa 
1               5                   10                  15      


Lys Arg Ala Lys Glu Phe Val Cys Trp Leu Leu Asp Thr 
            20                  25                  


<210>  78
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  Glucagon Analog 63

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  D-Ser

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  Acylated with C16 fatty acyl group via gamma-Glu-gamma-Glu spacer

<220>
<221>  MOD_RES
<222>  (16)..(16)
<223>  Xaa is AIB

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  78

His Ser Gln Gly Thr Phe Thr Ser Asp Lys Ser Lys Tyr Leu Asp Xaa 
1               5                   10                  15      


Lys Arg Ala Lys Glu Phe Val Cys Trp Leu Leu Asp Thr 
            20                  25                  


<210>  79
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  Glucagon analog 64

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is AIB

<220>
<221>  MOD_RES
<222>  (16)..(16)
<223>  Xaa is AIB

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  79

His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Xaa 
1               5                   10                  15      


Lys Ala Ala Lys Glu Phe Val Cys Trp Leu Leu Asp Thr 
            20                  25                  


<210>  80
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  Glucagon Analog 65

<220>
<221>  MISC_FEATURE
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  80

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Lys Arg Ala Lys Glu Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  


<210>  81
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  Glucagon Analog 66

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  81

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Ser 
1               5                   10                  15      


Lys Arg Ala Gln Glu Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  


<210>  82
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  Glucagon Analog 67

<400>  82

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Lys Asp Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  


<210>  83
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  Glucagon Analog 68

<400>  83

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Lys Glu Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  


<210>  84
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  Glucagon Analog 69

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is AIB

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  Acylated with a C16 fatty acyl group

<220>
<221>  MOD_RES
<222>  (16)..(16)
<223>  Xaa is AIB

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  84

His Xaa Gln Gly Thr Phe Thr Ser Asp Lys Ser Lys Tyr Leu Asp Xaa 
1               5                   10                  15      


Arg Ala Ala Gln Asp Phe Val Gln Trp Leu Met Asp Thr 
            20                  25                  


<210>  85
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  Glucagon Analog 70

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is AIB

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  Acylated with a C14 fatty acyl group via gamma-Glu-gamma-Glu 
       spacer

<220>
<221>  MOD_RES
<222>  (16)..(16)
<223>  Xaa is AIB

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  85

His Xaa Gln Gly Thr Phe Thr Ser Asp Lys Ser Lys Tyr Leu Asp Xaa 
1               5                   10                  15      


Arg Ala Ala Gln Asp Phe Val Gln Trp Leu Met Asp Thr 
            20                  25                  


<210>  86
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  Glucagon Analog 71

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is AIB

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  Acylated with a C18 fatty acyl group via gamma-Glu-gamma-Glu 
       spacer

<220>
<221>  MOD_RES
<222>  (16)..(16)
<223>  Xaa is AIB

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  86

His Xaa Gln Gly Thr Phe Thr Ser Asp Lys Ser Lys Tyr Leu Asp Xaa 
1               5                   10                  15      


Arg Ala Ala Gln Asp Phe Val Gln Trp Leu Met Asp Thr 
            20                  25                  


<210>  87
<211>  31
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  Glucagon Analog 74

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  D-Ser

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  Acylated with a C16 fatty acyl group via gamma-Glu spacer

<220>
<221>  MOD_RES
<222>  (31)..(31)
<223>  C-terminal amidation

<400>  87

His Ser Gln Gly Thr Phe Thr Ser Asp Lys Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Cys Trp Leu Leu Asp Thr Gly Glu 
            20                  25                  30      


<210>  88
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  Glucagon Analog 75

<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Xaa is Des-amino-His

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  Acylated with C16 fatty acyl group via gamma-Glu spacer

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  88

Xaa Ser Gln Gly Thr Phe Thr Ser Asp Lys Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Cys Trp Leu Leu Asp Thr 
            20                  25                  


<210>  89
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  Glucagon Analog 76

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  D-Ser

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  Acylated with a C16 fatty acyl group via gamma-Glu spacer

<400>  89

His Ser Gln Gly Thr Phe Thr Ser Asp Lys Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Cys Trp Leu Leu Asp Thr 
            20                  25                  


<210>  90
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  Glucagon analog 77

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  D-Ser

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  Acylated with a C16 fatty acyl group via gamma-Glu spacer

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Covalently bound to 40kDa PEG

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  90

His Ser Gln Gly Thr Phe Thr Ser Asp Lys Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Cys Trp Leu Leu Asp Thr 
            20                  25                  


<210>  91
<211>  31
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  Glucagon analog 78

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  D-Ser

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  Acylated with C16 fatty acyl group via gamma-Glu spacer

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Covalently bound to 40kDa PEG

<400>  91

His Ser Gln Gly Thr Phe Thr Ser Asp Lys Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Cys Trp Leu Leu Asp Thr Gly Gly 
            20                  25                  30      


<210>  92
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  Glucagon analog 79

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  D-Ser

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  Acylated with a C16 fatty acyl group via gamma-Glu spacer

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Covalently bound to 40kDa PEG

<400>  92

His Ser Gln Gly Thr Phe Thr Ser Asp Lys Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Cys Trp Leu Leu Asp Thr 
            20                  25                  


<210>  93
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  Glucagon Analog 80

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is AIB

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  Acylated with C16 fatty acyl group via gamma-Glu spacer

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Covalently bound to 40kDa PEG

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  93

His Xaa Gln Gly Thr Phe Thr Ser Asp Lys Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Ala Ala Gln Asp Phe Val Cys Trp Leu Leu Asp Thr 
            20                  25                  


<210>  94
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  Glucagon Analog 81

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  D-Ala

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  Acylated with C16 fatty acyl group via gamma-Glu spacer

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Covalently bound to 40kDa PEG

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  94

His Ala Gln Gly Thr Phe Thr Ser Asp Lys Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Ala Ala Gln Asp Phe Val Cys Trp Leu Leu Asp Thr 
            20                  25                  


<210>  95
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  Glucagon Analog 82

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  D-Ser

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  Acylated with C16 fatty acyl group via gamma-Glu spacer

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  95

His Ser Gln Gly Thr Phe Thr Ser Asp Lys Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Cys Trp Leu Leu Asp Glu 
            20                  25                  


<210>  96
<211>  30
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  Glucagon Analog 83

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  D-Ser

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  Acylated with a C16 fatty acyl group via gamma-Glu spacer

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Covalently bound to 40kDa PEG

<220>
<221>  MOD_RES
<222>  (30)..(30)
<223>  C-terminal amidation

<400>  96

His Ser Gln Gly Thr Phe Thr Ser Asp Lys Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Cys Trp Leu Leu Asp Thr Glu 
            20                  25                  30  


<210>  97
<211>  39
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  Glucagon Analog 84

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  D-Ser

<400>  97

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Val Arg Leu Phe Ile Cys Trp Leu Leu Asp Gly Gly Pro Ser 
            20                  25                  30          


Ser Gly Ala Pro Pro Pro Ser 
        35                  


<210>  98
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  Glucagon Analog 85

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  D-Ser

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  Acylated with C16 fatty acyl group via gamma-Glu spacer

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  98

His Ser Gln Gly Thr Phe Thr Ser Asp Lys Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Val Arg Leu Phe Ile Cys Trp Leu Leu Asp Thr 
            20                  25                  


<210>  99
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  Glucagon Analog 86

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  D-Ser

<220>
<221>  MOD_RES
<222>  (16)..(16)
<223>  Xaa is AIB

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  99

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Xaa 
1               5                   10                  15      


Lys Ala Val Arg Leu Phe Ile Cys Trp Leu Leu Asp Thr 
            20                  25                  


<210>  100
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  Glucagon Analog 87

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  D-Ser

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  100

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Val Arg Leu Phe Ile Cys Trp Leu Leu Asp Thr 
            20                  25                  


<210>  101
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  Glucagon Analog 88

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  D-Ser

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  Acylated with C16 fatty acyl group via gamma-Glu spacer

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  101

His Ser Gln Gly Thr Phe Thr Ser Asp Lys Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Cys Trp Leu Leu Asp Glu 
            20                  25                  


<210>  102
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  Glucagon Analog 89

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  D-Ser

<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  Lactam ring between side chains of amino acids

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  102

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Leu Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Cys Trp Leu Leu Asp Thr 
            20                  25                  


<210>  103
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  Glucagon Analog 90

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  D-Ser

<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  Lactam ring between side chains of amino acids

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  103

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Ala Ala Lys Asp Phe Val Cys Trp Leu Leu Asp Thr 
            20                  25                  


<210>  104
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  Glucagon Analog 91

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  D-Ser

<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  Lactam ring between side chains of amino acids

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Covalently bound to 40kDa PEG

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  104

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Leu Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Ala Ala Lys Asp Phe Val Cys Trp Leu Leu Asp Thr 
            20                  25                  


<210>  105
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  Glucagon Analog 92

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  D-Ser

<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  Lactam ring between side chains of amino acids

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Covalently bound to 40kDa PEG

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  105

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Cys Trp Leu Leu Asp Thr 
            20                  25                  


<210>  106
<211>  39
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  Glucagon Analog 93

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  D-Ser

<220>
<221>  MOD_RES
<222>  (16)..(16)
<223>  Xaa is AIB

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Covalently bound to 40kDa PEG

<220>
<221>  MOD_RES
<222>  (39)..(39)
<223>  C-terminal amidation

<400>  106

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Xaa 
1               5                   10                  15      


Lys Arg Ala Lys Glu Phe Val Cys Trp Leu Leu Asp Gly Gly Pro Ser 
            20                  25                  30          


Ser Gly Ala Pro Pro Pro Ser 
        35                  


<210>  107
<211>  39
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  Glucagon Analog 94

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  D-Ser

<220>
<221>  MOD_RES
<222>  (39)..(39)
<223>  C-terminal amidation

<400>  107

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Lys Arg Ala Lys Glu Phe Val Cys Trp Leu Leu Asp Gly Gly Pro Ser 
            20                  25                  30          


Ser Gly Ala Pro Pro Pro Ser 
        35                  


<210>  108
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  Glucagon Analog 95

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  D-Ser

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  Acylated with a C16 fatty acyl group via gamma-Glu spacer

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Covalently bound to 40kDa PEG

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  108

His Ser Gln Gly Thr Phe Thr Ser Asp Lys Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Cys Trp Leu Leu Asp Glu 
            20                  25                  


<210>  109
<211>  30
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  Glucagon Analog 96

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  D-Ser

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  Acylated with a C16 fatty acyl group via gamma-Glu spacer

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Covalently bound to a 40kDa PEG

<220>
<221>  MOD_RES
<222>  (30)..(30)
<223>  C-terminal amidation

<400>  109

His Ser Gln Gly Thr Phe Thr Ser Asp Lys Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Cys Trp Leu Leu Asp Thr Glu 
            20                  25                  30  


<210>  110
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  Glucagon analog 97

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  D-Ser

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  Acylated with C16 fatty acyl group via gamma-Glu spacer

<220>
<221>  MOD_RES
<222>  (16)..(16)
<223>  Xaa is AIB

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Covalently bound to a 40kDa PEG

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  110

His Ser Gln Gly Thr Phe Thr Ser Asp Lys Ser Lys Tyr Leu Asp Xaa 
1               5                   10                  15      


Lys Arg Ala Lys Glu Phe Val Cys Trp Leu Leu Asp Thr 
            20                  25                  


<210>  111
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  Glucagon Analog 98

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is AIB

<220>
<221>  MOD_RES
<222>  (16)..(16)
<223>  Xaa is AIB

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Covalently bound to a 40kDa PEG

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  111

His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Xaa 
1               5                   10                  15      


Lys Ala Ala Lys Glu Phe Val Cys Trp Leu Leu Asp Thr 
            20                  25                  


<210>  112
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  Glucagon Analog 99

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  D-Ser

<220>
<221>  MOD_RES
<222>  (16)..(16)
<223>  Xaa is AIB

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Covalently bound to 40kDa PEG

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  112

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Xaa 
1               5                   10                  15      


Lys Ala Val Arg Leu Phe Ile Cys Trp Leu Leu Asp Thr 
            20                  25                  


<210>  113
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  Glucagon Analog 100

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  D-Ser

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Covalently bound to 40kDa PEG

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  113

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Val Arg Leu Phe Ile Cys Trp Leu Leu Asp Thr 
            20                  25                  


<210>  114
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  Glucagon Analog 101

<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Xaa is Dmia

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Covalently bound to 40kDa PEG

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  114

Xaa Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Cys Trp Leu Met Asn Thr 
            20                  25                  


<210>  115
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  Analog A

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  115

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Glu Ala Val Arg Leu Phe Ile Glu Trp Leu Met Asn Thr 
            20                  25                  


<210>  116
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  Analog B

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  116

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Met Asn Thr 
            20                  25                  


<210>  117
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  Analog C

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is AIB

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  117

His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Glu Ala Val Arg Leu Phe Ile Glu Trp Leu Met Asn Thr 
            20                  25                  


<210>  118
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  Analog D

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is AIB

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  118

His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Met Asn Thr 
            20                  25                  


<210>  119
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  Glucagon analog 79

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  D-Ser

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  Acylated with a C16 fatty acyl group via gamma-Glu spacer

<400>  119

His Ser Gln Gly Thr Phe Thr Ser Asp Lys Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Cys Trp Leu Leu Asp Thr 
            20                  25                  


<210>  120
<211>  30
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  Glucagon Analog 83

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  D-Ser

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  Acylated with a C16 fatty acyl group via gamma-Glu spacer

<220>
<221>  MOD_RES
<222>  (30)..(30)
<223>  C-terminal amidation

<400>  120

His Ser Gln Gly Thr Phe Thr Ser Asp Lys Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Cys Trp Leu Leu Asp Thr Glu 
            20                  25                  30  


<210>  121
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is Aib

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  Acylated with a C16 fatty acyl group via dipeptide spacer of two 
       acidic amino acids

<220>
<221>  MOD_RES
<222>  (16)..(16)
<223>  Xaa is Aib

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  121

His Xaa Gln Gly Thr Phe Thr Ser Asp Lys Ser Lys Tyr Leu Asp Xaa 
1               5                   10                  15      


Arg Ala Ala Gln Asp Phe Val Gln Trp Leu Met Asp Thr 
            20                  25                  


<210>  122
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is Aib

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  Acylated with a C16 fatty acyl group via acid amino acidic spacer

<220>
<221>  MOD_RES
<222>  (16)..(16)
<223>  Xaa is Aib

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  122

His Xaa Gln Gly Thr Phe Thr Ser Asp Lys Ser Lys Tyr Leu Asp Xaa 
1               5                   10                  15      


Arg Ala Ala Gln Asp Phe Val Gln Trp Leu Met Asp Thr 
            20                  25                  


<210>  123
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  Glucagon Analog 230

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is AIB

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  Acylated with C16 fatty acyl group via acidic amino acid spacer

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Covalently bound to 40kDa PEG

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  123

His Xaa Gln Gly Thr Phe Thr Ser Asp Lys Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Cys Trp Leu Leu Asp Thr 
            20                  25                  


<210>  124
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  Glucagon Analog 237

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  Acylated with C16 fatty acyl group via acidic amino acid spacer

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  124

His Ser Gln Gly Thr Phe Thr Ser Asp Lys Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Glu Ala Val Arg Leu Phe Ile Glu Trp Leu Met Asn Thr 
            20                  25                  


<210>  125
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  Glucagon Analog 238

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is AIB

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  Acylated with C16 fatty acyl group via acidic amino acid spacer

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  125

His Xaa Gln Gly Thr Phe Thr Ser Asp Lys Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Glu Ala Val Arg Leu Phe Ile Glu Trp Leu Met Asn Thr 
            20                  25                  


<210>  126
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  Glucagon Analog 242

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is Aminoisobutyric acid

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  Acylated with a C16 fatty acyl group via dipeptide spacer of two 
       acidic amino acids

<220>
<221>  MOD_RES
<222>  (16)..(16)
<223>  Xaa is AIB

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  126

His Xaa Gln Gly Thr Phe Thr Ser Asp Lys Ser Lys Tyr Leu Asp Xaa 
1               5                   10                  15      


Arg Ala Ala Gln Asp Phe Val Gln Trp Leu Met Asp Thr 
            20                  25                  


<210>  127
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  Glucagon Analog 243

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is AIB

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  Acylated with a C16 fatty acyl group via acidic amino acid spacer

<220>
<221>  MOD_RES
<222>  (16)..(16)
<223>  Xaa is AIB

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  127

His Xaa Gln Gly Thr Phe Thr Ser Asp Lys Ser Lys Tyr Leu Asp Xaa 
1               5                   10                  15      


Arg Ala Ala Gln Asp Phe Val Gln Trp Leu Met Asp Thr 
            20                  25                  


<210>  128
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  Glucagon Analog 245

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is AIB

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  Acylated with a C16 fatty acyl group via dipeptide spacer of two 
       acidic amino acids

<220>
<221>  MOD_RES
<222>  (16)..(16)
<223>  Xaa is AIB

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  128

His Xaa Glu Gly Thr Phe Thr Ser Asp Lys Ser Lys Tyr Leu Asp Xaa 
1               5                   10                  15      


Arg Ala Ala Gln Asp Phe Val Gln Trp Leu Met Asp Thr 
            20                  25                  


<210>  129
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  Glucagon Analog 246

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is AIB

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  Acylated with a C16 fatty acyl group via dipeptide spacer of two 
       acidic amino acids

<220>
<221>  MOD_RES
<222>  (16)..(16)
<223>  Xaa is AIB

<400>  129

His Xaa Gln Gly Thr Phe Ile Ser Asp Lys Ser Lys Tyr Leu Asp Xaa 
1               5                   10                  15      


Arg Ala Ala Gln Asp Phe Val Gln Trp Leu Met Asp Thr 
            20                  25                  


<210>  130
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  Glucagon Analog 248

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is AIB

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  Acylated with a C16 fatty acyl group via dipeptide spacer of two 
       acidic amino acids

<220>
<221>  MOD_RES
<222>  (16)..(16)
<223>  Xaa is AIB

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  130

His Xaa Gln Gly Thr Phe Thr Ser Asp Lys Ser Lys Tyr Leu Glu Xaa 
1               5                   10                  15      


Arg Ala Ala Gln Asp Phe Val Gln Trp Leu Met Asp Thr 
            20                  25                  


<210>  131
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  Glucagon Analog 249

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is AIB

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  Acylated with a C16 fatty acyl group via dipeptide spacer of two 
       acidic amino acids

<220>
<221>  MOD_RES
<222>  (16)..(16)
<223>  Xaa is AIB

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  131

His Xaa Gln Gly Thr Phe Thr Ser Asp Lys Ser Lys Tyr Leu Asp Xaa 
1               5                   10                  15      


Arg Ala Ala Gln Asp Phe Val Gln Trp Leu Leu Asp Thr 
            20                  25                  


<210>  132
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  Glucagon Analog 250

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is AIB

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  Acylated with a C16 fatty acyl group via dipeptide spacer of two 
       acidic amino acids

<400>  132

His Xaa Gln Gly Thr Phe Thr Ser Asp Lys Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Ala Ala Gln Asp Phe Val Gln Trp Leu Met Asp Thr 
            20                  25                  


<210>  133
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  Glucagon Analog 252

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is AIB

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  Acylated with C16 fatty acyl group via acidic amino acid spacer

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  133

His Xaa Gln Gly Thr Phe Thr Ser Asp Lys Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Leu Asp Thr 
            20                  25                  


<210>  134
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  Glucagon Analog 254

<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Xaa is DMIA

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  Acylated with C16 fatty acyl group via acidic amino acid spacer

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  134

Xaa Ser Gln Gly Thr Phe Thr Ser Asp Lys Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Cys Trp Leu Leu Asp Thr 
            20                  25                  


<210>  135
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  Glucagon Analog 257

<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Ac-His

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  Acylated with C16 fatty acyl group via acidic amino acid spacer

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  135

His Ser Gln Gly Thr Phe Thr Ser Asp Lys Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Cys Trp Leu Leu Asp Thr 
            20                  25                  


<210>  136
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  Glucagon Analog 258

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is AIB

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  Acylated with C16 fatty acyl group via acidic amino acid spacer

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  136

His Xaa Gln Gly Thr Phe Thr Ser Asp Lys Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Ala Ala Gln Asp Phe Val Cys Trp Leu Leu Asp Thr 
            20                  25                  


<210>  137
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  Glucagon Analog 259

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  D-Ala

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  Acylated with C16 fatty acyl group via acidic amino acid spacer

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  137

His Ala Gln Gly Thr Phe Thr Ser Asp Lys Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Ala Ala Gln Asp Phe Val Cys Trp Leu Leu Asp Thr 
            20                  25                  


<210>  138
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  Glucagon Analog 270

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is AIB

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  Acylated with a C16 fatty acyl group via dipeptide spacer of two 
       acidic amino acids

<220>
<221>  MOD_RES
<222>  (16)..(16)
<223>  Xaa is AIB

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  138

His Xaa Gln Gly Thr Phe Thr Ser Asp Lys Ser Lys Tyr Leu Asp Xaa 
1               5                   10                  15      


Arg Ala Ala Gln Asp Phe Val Gln Trp Leu Met Asp Thr 
            20                  25                  


<210>  139
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  Glucagon Analog 271

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is AIB

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  Acylated with a C16 fatty acyl group via dipeptide spacer of two 
       acidic amino acids

<220>
<221>  MOD_RES
<222>  (16)..(16)
<223>  Xaa is AIB

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  139

His Xaa Gln Gly Thr Phe Thr Ser Asp Lys Ser Lys Tyr Leu Asp Xaa 
1               5                   10                  15      


Arg Ala Ala Gln Asp Phe Val Gln Trp Leu Met Asp Thr 
            20                  25                  


<210>  140
<211>  31
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  Glucagon Analog 274

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is D-Ser, D-Ala, Val, Gly, N-methyl Ser, alpha, amino 
       isobutyric acid

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  Acylated with a C16 fatty acyl group via acidic amino acid spacer

<220>
<221>  MOD_RES
<222>  (31)..(31)
<223>  C-terminal amidation

<400>  140

His Ser Gln Gly Thr Phe Thr Ser Asp Lys Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Cys Trp Leu Leu Asp Thr Gly Glu 
            20                  25                  30      


<210>  141
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  Glucagon Analog 275

<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Xaa is Des-amino-His

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  Acylated with C16 fatty acyl group via acidic amino acid spacer

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  141

Xaa Ser Gln Gly Thr Phe Thr Ser Asp Lys Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Cys Trp Leu Leu Asp Thr 
            20                  25                  


<210>  142
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  Glucagon Analog 280

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is AIB

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  Acylated with C16 fatty acyl group via acidic amino acid spacer

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Covalently bound to 40kDa PEG

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  142

His Xaa Gln Gly Thr Phe Thr Ser Asp Lys Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Ala Ala Gln Asp Phe Val Cys Trp Leu Leu Asp Thr 
            20                  25                  


<210>  143
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  Glucagon Analog 222

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is D-Ser, D-Ala, Val, Gly, N-methyl Ser, or alpha, amino 
       isobutyric acid

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  Acylated with C16 fatty acyl group via acidic amino acid spacer

<220>
<221>  MISC_FEATURE
<222>  (15)..(20)
<223>  Salt bridge

<220>
<221>  MOD_RES
<222>  (16)..(16)
<223>  Xaa is AIB

<220>
<221>  MISC_FEATURE
<222>  (16)..(21)
<223>  Salt bridge

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  143

His Xaa Gln Gly Thr Phe Thr Ser Asp Lys Ser Lys Tyr Leu Asp Xaa 
1               5                   10                  15      


Lys Arg Ala Lys Glu Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  


<210>  144
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  Glucagon Analog 229

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is D-Ser, D-Ala, Val, Gly, N-methyl Ser, or alpha, amino 
       isobutyric acid

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  Acylated with C16 fatty acyl group via acidic amino acid spacer

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Covalently bound to 40kDa PEG

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  144

His Xaa Gln Gly Thr Phe Thr Ser Asp Lys Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Ala Ala Gln Asp Phe Val Cys Trp Leu Leu Asp Thr 
            20                  25                  


<210>  145
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  Glucagon Analog 244

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is D-Ser, D-Ala, Val, Gly, N-methyl Ser, or alpha, amino 
       isobutyric acid

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  Acylated with C16 fatty acyl group via dipeptide spacer of two 
       acidic residues

<220>
<221>  MOD_RES
<222>  (16)..(16)
<223>  Xaa is AIB

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  145

His Xaa Gln Gly Thr Phe Thr Ser Asp Lys Ser Lys Tyr Leu Glu Xaa 
1               5                   10                  15      


Arg Ala Ala Gln Asp Phe Val Gln Trp Leu Met Asp Thr 
            20                  25                  


<210>  146
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  Glucagon Analog 251

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is D-Ser, D-Ala, Val, Gly, N-methyl Ser, or alpha, amino 
       isobutyric acid

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  Acylated with C16 fatty acyl group via acidic amino acid spacer

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  146

His Xaa Gln Gly Thr Phe Thr Ser Asp Lys Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Ala Ala Gln Asp Phe Val Gln Trp Leu Leu Asp Thr 
            20                  25                  


<210>  147
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  Peptide 253

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is D-Ser, D-Ala, Val, Gly, N-methyl Ser, or alpha, amino 
       isobutyric acid

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  Acylated with C16 fatty acyl group via acidic amino acid spacer

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  PEGYLATION

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  147

His Xaa Gln Gly Thr Phe Thr Ser Asp Lys Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Cys Trp Leu Leu Asp Thr 
            20                  25                  


<210>  148
<211>  30
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  Glucagon Analog 55

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is D-Ser, D-Ala, Val, Gly, N-methyl Ser, or alpha, amino 
       isobutyric acid

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  Acylated with C16 fatty acyl group via acidic amino acid spacer

<400>  148

His Ser Gln Gly Thr Phe Thr Ser Asp Lys Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Cys Trp Leu Leu Asp Thr Gly 
            20                  25                  30  


<210>  149
<211>  31
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  Glucagon Analog 256

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is D-Ser, D-Ala, Val, Gly, N-methyl Ser, or alpha, amino 
       isobutyric acid

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  Acylated with C16 fatty acyl group via acidic amino acid spacer

<400>  149

His Xaa Gln Gly Thr Phe Thr Ser Asp Lys Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Cys Trp Leu Leu Asp Thr Gly Gly 
            20                  25                  30      


<210>  150
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  Glucagon Analog 262

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is D-Ser, D-Ala, Val, Gly, N-methyl Ser, or alpha, amino 
       isobutyric acid

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  Acylated with a C16 fatty acyl group via acidic amino acid spacer

<220>
<221>  MOD_RES
<222>  (16)..(16)
<223>  Xaa is AIB

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  150

His Xaa Gln Gly Thr Phe Thr Ser Asp Lys Ser Lys Tyr Leu Asp Xaa 
1               5                   10                  15      


Lys Arg Ala Lys Glu Phe Val Cys Trp Leu Leu Asp Thr 
            20                  25                  


<210>  151
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  Glucagon Analog 263

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is D-Ser, D-Ala, Val, Gly, N-methyl Ser, or alpha, amino 
       isobutyric acid

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  Acylated with C16 fatty acyl group via dipeptide spacer of two 
       acidic residues

<220>
<221>  MOD_RES
<222>  (16)..(16)
<223>  Xaa is AIB

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  151

His Xaa Gln Gly Thr Phe Thr Ser Asp Lys Ser Lys Tyr Leu Asp Xaa 
1               5                   10                  15      


Lys Arg Ala Lys Glu Phe Val Cys Trp Leu Leu Asp Thr 
            20                  25                  


<210>  152
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  Glucagon Analog 276

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is D-Ser, D-Ala, Val, Gly, N-methyl Ser, or alpha, amino 
       isobutyric acid

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  Acylated with a C16 fatty acyl group via acidic amino acid spacer

<400>  152

His Xaa Gln Gly Thr Phe Thr Ser Asp Lys Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Cys Trp Leu Leu Asp Thr 
            20                  25                  


<210>  153
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  Glucagon analog 277

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is D-Ser, D-Ala, Val, Gly, N-methyl Ser, or alpha, amino 
       isobutyric acid

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  Acylated with a C16 fatty acyl group via acidic amino acid spacer

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Covalently bound to 40kDa PEG

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  153

His Xaa Gln Gly Thr Phe Thr Ser Asp Lys Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Cys Trp Leu Leu Asp Thr 
            20                  25                  


<210>  154
<211>  31
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  Glucagon analog 278

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is D-Ser, D-Ala, Val, Gly, N-methyl Ser, or alpha, amino 
       isobutyric acid

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  Acylated with C16 fatty acyl group via acidic amino acid spacer

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Covalently bound to 40kDa PEG

<400>  154

His Xaa Gln Gly Thr Phe Thr Ser Asp Lys Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Cys Trp Leu Leu Asp Thr Gly Gly 
            20                  25                  30      


<210>  155
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  Glucagon analog 279

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is D-Ser, D-Ala, Val, Gly, N-methyl Ser, or alpha, amino 
       isobutyric acid

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  Acylated with a C16 fatty acyl group via acidic amino acid spacer

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Covalently bound to 40kDa PEG

<400>  155

His Xaa Gln Gly Thr Phe Thr Ser Asp Lys Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Cys Trp Leu Leu Asp Thr 
            20                  25                  


<210>  156
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  Glucagon Analog 282

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is D-Ser, D-Ala, Val, Gly, N-methyl Ser, or alpha, amino 
       isobutyric acid

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  Acylated with C16 fatty acyl group via acidic amino acid spacer

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  156

His Xaa Gln Gly Thr Phe Thr Ser Asp Lys Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Cys Trp Leu Leu Asp Glu 
            20                  25                  


<210>  157
<211>  30
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  Glucagon Analog 283

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is D-Ser, D-Ala, Val, Gly, N-methyl Ser, or alpha, amino 
       isobutyric acid

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  Acylated with a C16 fatty acyl group via acidic amino acid spacer

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Covalently bound to 40kDa PEG

<220>
<221>  MOD_RES
<222>  (30)..(30)
<223>  C-terminal amidation

<400>  157

His Xaa Gln Gly Thr Phe Thr Ser Asp Lys Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Cys Trp Leu Leu Asp Thr Glu 
            20                  25                  30  


<210>  158
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  Glucagon Analog 285

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is D-Ser, D-Ala, Val, Gly, N-methyl Ser, or alpha, amino 
       isobutyric acid

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  Acylated with C16 fatty acyl group via acidic amino acid spacer

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  158

His Ser Gln Gly Thr Phe Thr Ser Asp Lys Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Val Arg Leu Phe Ile Cys Trp Leu Leu Asp Thr 
            20                  25                  


<210>  159
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  Glucagon Analog 288

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is D-Ser, D-Ala, Val, Gly, N-methyl Ser, or alpha, amino 
       isobutyric acid

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  Acylated with C16 fatty acyl group via acidic amino acid spacer

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  159

His Xaa Gln Gly Thr Phe Thr Ser Asp Lys Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Cys Trp Leu Leu Asp Glu 
            20                  25                  


<210>  160
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  Glucagon Analog 295

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is D-Ser, D-Ala, Val, Gly, N-methyl Ser, or alpha, amino 
       isobutyric acid

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  Acylated with a C16 fatty acyl group via acidic amino acid spacer

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Covalently bound to 40kDa PEG

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  160

His Ser Gln Gly Thr Phe Thr Ser Asp Lys Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Cys Trp Leu Leu Asp Glu 
            20                  25                  


<210>  161
<211>  30
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  Glucagon Analog 296

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is D-Ser, D-Ala, Val, Gly, N-methyl Ser, or alpha, amino 
       isobutyric acid

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  Acylated with a C16 fatty acyl group via acidic amino acid spacer

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Covalently bound to a 40kDa PEG

<220>
<221>  MOD_RES
<222>  (30)..(30)
<223>  C-terminal amidation

<400>  161

His Ser Gln Gly Thr Phe Thr Ser Asp Lys Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Cys Trp Leu Leu Asp Thr Glu 
            20                  25                  30  


<210>  162
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  Glucagon analog 297

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is D-Ser, D-Ala, Val, Gly, N-methyl Ser, or alpha, amino 
       isobutyric acid

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  Acylated with C16 fatty acyl group via acidic amino acid spacer

<220>
<221>  MOD_RES
<222>  (16)..(16)
<223>  Xaa is AIB

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Covalently bound to a 40kDa PEG

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  162

His Ser Gln Gly Thr Phe Thr Ser Asp Lys Ser Lys Tyr Leu Asp Xaa 
1               5                   10                  15      


Lys Arg Ala Lys Glu Phe Val Cys Trp Leu Leu Asp Thr 
            20                  25                  


<210>  163
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  Glucagon analog 279

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is D-Ser, D-Ala, Val, Gly, N-methyl Ser, or alpha, amino 
       isobutyric acid

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  Acylated with a C16 fatty acyl group via acidic amino acid spacer

<400>  163

His Ser Gln Gly Thr Phe Thr Ser Asp Lys Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Cys Trp Leu Leu Asp Thr 
            20                  25                  


<210>  164
<211>  30
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  Glucagon Analog 283

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is D-Ser, D-Ala, Val, Gly, N-methyl Ser, or alpha, amino 
       isobutyric acid

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  Acylated with a C16 fatty acyl group via acidic amino acid spacer

<220>
<221>  MOD_RES
<222>  (30)..(30)
<223>  C-terminal amidation

<400>  164

His Ser Gln Gly Thr Phe Thr Ser Asp Lys Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Cys Trp Leu Leu Asp Thr Glu 
            20                  25                  30  


<210>  165
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  Glucagon Analog 220

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is D-Ser, D-Ala, Val, Gly, N-methyl Ser, or alpha, amino 
       isobutyric acid

<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  Salt bridge

<220>
<221>  MISC_FEATURE
<222>  (17)..(21)
<223>  Salt bridge

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  165

His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Lys Arg Ala Lys Glu Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  


<210>  166
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  Glucagon Analog 221

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is D-Ser, D-Ala, Val, Gly, N-methyl Ser, or alpha, amino 
       isobutyric acid

<220>
<221>  MOD_RES
<222>  (16)..(16)
<223>  Xaa is AIB

<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  Salt bridge

<220>
<221>  MISC_FEATURE
<222>  (17)..(21)
<223>  Salt bridge

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  166

His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Xaa 
1               5                   10                  15      


Lys Arg Ala Lys Glu Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  


<210>  167
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  Glucagon Analog 224

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is D-Ser, D-Ala, Val, Gly, N-methyl Ser, or alpha, amino 
       isobutyric acid

<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  Salt bridge

<220>
<221>  MISC_FEATURE
<222>  (17)..(21)
<223>  Salt bridge

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Covalently bound to 40kDa PEG

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  167

His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Lys Arg Ala Lys Glu Phe Val Cys Trp Leu Met Asn Thr 
            20                  25                  


<210>  168
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  Glucagon Analog 226

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is D-Ser, D-Ala, Val, Gly, N-methyl Ser, or alpha, amino 
       isobutyric acid

<220>
<221>  MOD_RES
<222>  (16)..(16)
<223>  Xaa is AIB

<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  Salt bridge

<220>
<221>  MISC_FEATURE
<222>  (17)..(21)
<223>  Salt bridge

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Covalently bound to 40kDa PEG

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  168

His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Xaa 
1               5                   10                  15      


Lys Arg Ala Lys Glu Phe Val Cys Trp Leu Met Asn Thr 
            20                  25                  


<210>  169
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  Glucagon Analog 231

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is D-Ser, D-Ala, Val, Gly, N-methyl Ser, or alpha, amino 
       isobutyric acid

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  169

His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Glu Ala Val Arg Leu Phe Ile Glu Trp Leu Met Asn Thr 
            20                  25                  


<210>  170
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  Glucagon Analog 233

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is D-Ser, D-Ala, Val, Gly, N-methyl Ser, or alpha, amino 
       isobutyric acid

<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  Salt bridge

<220>
<221>  MISC_FEATURE
<222>  (17)..(21)
<223>  Salt bridge

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  170

His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Glu Ala Val Arg Leu Phe Ile Cys Trp Leu Met Asn Thr 
            20                  25                  


<210>  171
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  Glucagon Analog 235

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is D-Ser, D-Ala, Val, Gly, N-methyl Ser, or alpha, amino 
       isobutyric acid

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Covalently bound to 40kDa PEG

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  171

His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Glu Ala Val Arg Leu Phe Ile Cys Trp Leu Met Asn Thr 
            20                  25                  


<210>  172
<211>  39
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  Glucagon Analog 260

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is D-Ser, D-Ala, Val, Gly, N-methyl Ser, or alpha, amino 
       isobutyric acid

<220>
<221>  MOD_RES
<222>  (16)..(16)
<223>  Xaa is AIB

<220>
<221>  MOD_RES
<222>  (39)..(39)
<223>  C-terminal amidation

<400>  172

His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Xaa 
1               5                   10                  15      


Lys Arg Ala Lys Glu Phe Val Cys Trp Leu Leu Asp Gly Gly Pro Ser 
            20                  25                  30          


Ser Gly Ala Pro Pro Pro Ser 
        35                  


<210>  173
<211>  39
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  Glucagon Analog 261

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is D-Ser, D-Ala, Val, Gly, N-methyl Ser, or alpha, amino 
       isobutyric acid

<220>
<221>  MOD_RES
<222>  (39)..(39)
<223>  C-terminal amidation

<400>  173

His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Lys Arg Ala Lys Glu Phe Val Cys Trp Leu Leu Asp Gly Gly Pro Ser 
            20                  25                  30          


Ser Gly Ala Pro Pro Pro Ser 
        35                  


<210>  174
<211>  39
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  Glucagon Analog 284

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is D-Ser, D-Ala, Val, Gly, N-methyl Ser, or alpha, amino 
       isobutyric acid

<400>  174

His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Val Arg Leu Phe Ile Cys Trp Leu Leu Asp Gly Gly Pro Ser 
            20                  25                  30          


Ser Gly Ala Pro Pro Pro Ser 
        35                  


<210>  175
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  Glucagon Analog 286

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is D-Ser, D-Ala, Val, Gly, N-methyl Ser, or alpha, amino 
       isobutyric acid

<220>
<221>  MOD_RES
<222>  (16)..(16)
<223>  Xaa is AIB

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  175

His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Xaa 
1               5                   10                  15      


Lys Ala Val Arg Leu Phe Ile Cys Trp Leu Leu Asp Thr 
            20                  25                  


<210>  176
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  Glucagon Analog 287

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is D-Ser, D-Ala, Val, Gly, N-methyl Ser, or alpha, amino 
       isobutyric acid

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  176

His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Val Arg Leu Phe Ile Cys Trp Leu Leu Asp Thr 
            20                  25                  


<210>  177
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  Glucagon Analog 289

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is D-Ser, D-Ala, Val, Gly, N-methyl Ser, or alpha, amino 
       isobutyric acid

<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  Lactam ring between side chains of amino acids

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  177

His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Leu Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Cys Trp Leu Leu Asp Thr 
            20                  25                  


<210>  178
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  Glucagon Analog 290

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is D-Ser, D-Ala, Val, Gly, N-methyl Ser, or alpha, amino 
       isobutyric acid

<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  Lactam ring between side chains of amino acids

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  178

His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Ala Ala Lys Asp Phe Val Cys Trp Leu Leu Asp Thr 
            20                  25                  


<210>  179
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  Glucagon Analog 291

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is D-Ser, D-Ala, Val, Gly, N-methyl Ser, or alpha, amino 
       isobutyric acid

<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  Lactam ring between side chains of amino acids

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Covalently bound to 40kDa PEG

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  179

His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Leu Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Ala Ala Lys Asp Phe Val Cys Trp Leu Leu Asp Thr 
            20                  25                  


<210>  180
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  Glucagon Analog 292

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is D-Ser, D-Ala, Val, Gly, N-methyl Ser, or alpha, amino 
       isobutyric acid

<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  Lactam ring between side chains of amino acids

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Covalently bound to 40kDa PEG

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  180

His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Cys Trp Leu Leu Asp Thr 
            20                  25                  


<210>  181
<211>  39
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  Glucagon Analog 293

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is D-Ser, D-Ala, Val, Gly, N-methyl Ser, or alpha, amino 
       isobutyric acid

<220>
<221>  MOD_RES
<222>  (16)..(16)
<223>  Xaa is AIB

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Covalently bound to 40kDa PEG

<220>
<221>  MOD_RES
<222>  (39)..(39)
<223>  C-terminal amidation

<400>  181

His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Xaa 
1               5                   10                  15      


Lys Arg Ala Lys Glu Phe Val Cys Trp Leu Leu Asp Gly Gly Pro Ser 
            20                  25                  30          


Ser Gly Ala Pro Pro Pro Ser 
        35                  


<210>  182
<211>  39
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  Glucagon Analog 294

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is D-Ser, D-Ala, Val, Gly, N-methyl Ser, or alpha, amino 
       isobutyric acid

<220>
<221>  MOD_RES
<222>  (39)..(39)
<223>  C-terminal amidation

<400>  182

His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Lys Arg Ala Lys Glu Phe Val Cys Trp Leu Leu Asp Gly Gly Pro Ser 
            20                  25                  30          


Ser Gly Ala Pro Pro Pro Ser 
        35                  


<210>  183
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  Glucagon Analog 299

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is D-Ser, D-Ala, Val, Gly, N-methyl Ser, or alpha, amino 
       isobutyric acid

<220>
<221>  MOD_RES
<222>  (16)..(16)
<223>  Xaa is AIB

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Covalently bound to 40kDa PEG

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  183

His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Xaa 
1               5                   10                  15      


Lys Ala Val Arg Leu Phe Ile Cys Trp Leu Leu Asp Thr 
            20                  25                  


<210>  184
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  Glucagon Analog 2100

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is D-Ser, D-Ala, Val, Gly, N-methyl Ser, or alpha, amino 
       isobutyric acid

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Covalently bound to 40kDa PEG

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  184

His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Val Arg Leu Phe Ile Cys Trp Leu Leu Asp Thr 
            20                  25                  


<210>  185
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is D-Ser, D-Ala, Val, Gly, N-methyl Ser, alpha, amino 
       isobutyric acid

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Covalently bound to 40kDa PEG

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  185

His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Glu Ala Val Arg Leu Phe Ile Cys Trp Leu Met Asn Thr 
            20                  25                  


<210>  186
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is D-Ser, D-Ala, Val, Gly, N-methyl Ser, alpha, amino 
       isobutyric acid

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  Acylated with a C16 fatty acyl group via gamma-Glu spacer

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  186

His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Glu Ala Val Arg Leu Phe Ile Cys Trp Leu Met Asn Thr 
            20                  25                  


<210>  187
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is D-Ser, D-Ala, Val, Gly, N-methyl Ser, alpha, amino 
       isobutyric acid

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  Acylated with a C16 fatty acyl group via acidic amino acid spacer

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  187

His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Glu Ala Val Arg Leu Phe Ile Cys Trp Leu Met Asn Thr 
            20                  25                  


<210>  188
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  Glucagon Analog 281

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  D-Ala

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  Acylated with C16 fatty acyl group via acidic amino acid spacer

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Covalently bound to 40kDa PEG

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  188

His Ala Gln Gly Thr Phe Thr Ser Asp Lys Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Ala Ala Gln Asp Phe Val Cys Trp Leu Leu Asp Thr 
            20                  25                  


