                         SEQUENCE LISTING

<110>  Koninklijke Philips Electronics N.V.
 
<120>  NOVEL TUMOR MARKERS

<130>  PH014716 WO1

<150>  EP 09179125.1
<151>  2009-12-14

<150>  EP 10165039.8
<151>  2010-06-07

<160>  957   

<170>  PatentIn version 3.5

<210>  1
<211>  1387
<212>  DNA
<213>  Homo sapiens

<400>  1
ccctcaccgg gggcaggagg gaccaaggct gggcccagaa cacatagtcc tagggtaaca       60

gtgaaggggt cgtgagggga cagtgactcc cttccaaccc cttcttcata gggactgttg      120

gcaaacaaag aaaatcaact gggaaaatga agacctgctg gaaaattcca gttttcttct      180

ttgtgtgcag tttcctggaa ccctgggcat ctgcagctgt caagcgtcgc cccagattcc      240

ctgtcaattc caattctaat ggtggaaatg aactctgtcc aaagatcagg attggccaag      300

atgacttacc agggtttgat ctgatctctc agttccaggt agataaagca gcatctagaa      360

gagctatcca gagagtagtg ggatcagcta cattgcaggt ggcttacaag ttgggaaata      420

atgtagactt caggattcca actaggaatt tatatcccag tggactgcct gaagaatact      480

ccttcttgac gacgtttcga atgactggaa gcactctcaa aaagaactgg aacatttggc      540

agattcagga ttcctctggg aaggagcaag ttggcataaa gattaatggc caaacacaat      600

ctgttgtatt ttcatacaag ggactggatg gaagtctcca aacagcagcc ttttcgaatt      660

tgtcctcctt gtttgattcc cagtggcata agatcatgat tggcgtggag aggagtagtg      720

ctactctttt tgttgactgc aacaggattg aatctttacc tataaagcca agaggcccaa      780

ttgacattga tggctttgct gtgctgggaa aacttgcaga taatcctcaa gtttctgttc      840

catttgaact tcaatggatg ctgatccatt gtgaccccct gcggcccagg agagaaactt      900

gccatgagct gccagccaga ataacgccca gccagaccac cgacgagaga ggtcccccgg      960

gtgagcaggg tcctcccggg cctccgggcc cccctggagt tccaggcatc gatggcatcg     1020

acggtgaccg aggtcctaag ggccccccgg gccccccggg tcctgcaggt gaaccgggaa     1080

agccaggagc tccaggcaag cctggcacac ctggcgctga taccagtcct tgactttgtc     1140

cctggaatat gaagtgaagt aagaaatggc gtctgttctt agcataccat ggtgcatcac     1200

tcaagttact cttcaagtta ccactttatg tgttttccaa aaactaaaga cttttctaaa     1260

tgaaagaaag cactcgaaaa cctataatta tgatttccaa gaatttttga ctacagttta     1320

agacatatcc ttcattttga aagaaaaata aataactgga tttttactgt taaaaaaaaa     1380

aaaaaaa                                                               1387


<210>  2
<211>  3555
<212>  DNA
<213>  Homo sapiens

<400>  2
tttccctttt ttttcctttt ggcaacccac acccttccac acacgctcac cccaaaatta       60

aacaccaaga tcctctaact tgtttggatt gactgatgaa gacataaagc tctatgtttt      120

ttgaggtgga gtgagtggtt tttcttcatt tttaaatggc caaatgacag cttgacccag      180

tttgctttcc aatcaaaggg catttatttt gaatgtctct ttgtggcgca agagccaacg      240

caaaaatgat ggcggcttac aatggcggta catctgcagc agcagcaggt caccaccacc      300

accatcacca ccaccttcca cacctccctc ctcctcacct gcaccaccac caccaccctc      360

aacaccatct tcatccgggg tcggctgccg ctgtacaccc tgtacagcag cacacctctt      420

cggcagctgc ggcagccgca gcagcggctg cagctgcagc catgttaaac cctgggcaac      480

aacagccata tttcccatca ccggcaccgg ggcaggctcc tggaccagct gcagcagccc      540

cagctcaggt acaggctgcc gcagctgcta cagttaaggc gcaccatcat cagcactcgc      600

atcatccaca gcagcagctg gatattgagc cggatagacc tattggatat ggagcctttg      660

gtgttgtctg gtcagtaaca gatccaagag atggaaagag agtagcgctc aaaaagatgc      720

ccaacgtctt ccagaatctg gtctcttgca aaagggtctt ccgggaattg aagatgttgt      780

gtttttttaa gcatgataat gtactctctg cccttgacat actccaacct ccacacattg      840

actattttga agaaatatat gttgtcacag aattgatgca gagtgaccta cataaaatta      900

tcgtctctcc tcaaccactc agctcagatc atgtcaaagt ttttctttat cagattttgc      960

gaggtttgaa atatctccat tcagctggca ttttacatcg agacattaag ccagggaatc     1020

tccttgtgaa cagcaactgt gttctaaaga tttgtgattt tggattggcc agagtggaag     1080

aattagatga atcccgtcat atgactcagg aagttgttac tcagtattat cgggctccag     1140

aaatcctgat gggcagccgt cattacagca atgctattga catctggtct gtgggatgta     1200

tctttgcaga actactagga cgaagaatat tgtttcaggc acagagtccc attcagcagt     1260

tggatttgat cacggatctg ttgggcacac catcactgga agcaatgagg acagcttgtg     1320

aaggcgctaa ggcacatata ctcaggggtc ctcataaaca gccatctctt cctgtactct     1380

ataccctgtc tagccaggct acacatgaag ctgttcatct cctttgcagg atgttggtct     1440

ttgatccatc caaaagaata tccgctaagg atgccttagc ccacccctac ctagatgaag     1500

ggcgactacg atatcacaca tgtatgtgta aatgttgctt ttccacctcc actggaagag     1560

tttataccag tgactttgag cctgtcacca atcccaaatt tgatgacact ttcgagaaga     1620

acctcagttc tgtccgacag gttaaagaaa ttattcatca gttcattttg gaacagcaga     1680

aaggaaacag agtgcctctc tgcatcaacc ctcagtctgc tgcttttaag agctttatta     1740

gttccactgt tgctcagcca tctgagatgc ccccatctcc tctggtgtgg gagtgatggt     1800

ggaagataat gtactactga agatgtaatg tagctttcca ctggagtctg ggatttgcaa     1860

ttctggaggt taatcatgct tgtactgtaa ttttactaat gaagttttaa attaacaacc     1920

actacttgta tgatatgaat aatatttaga aatgttacta gacttttaat cttgtaaagt     1980

ggttgtgctt ttagaagaaa aatattttac ccagagttgc acatgtttta tgaatttagt     2040

gcagctgtta tggctcacct cagaacaaaa gagaattgaa ccaaatttgg gagtttgggg     2100

ttttatgttt tgtttttctt ttctaaaatg aagtgagatt gttcacacac acacacacac     2160

acacacacac acacaaacac aaaggacagt catacatttt gatatttgag ccattcctaa     2220

agatttgggg ttttctaaaa ctaaagaatc taggaacctt gcctgcgacc aatcatggag     2280

ccacgtgagc tgatcgtggc tgcacctggg gggagggtag ggaggagggg catgccacct     2340

aatgatcaag ccctataatt agcttctcat tagagccgtg atggtgatgt gtgctgtcta     2400

aaatccaatg ttgtgggtag agagaatgag tttgtgacta ggagagacta aacttttgtt     2460

ttccttaccc agtataaata tatatatata tatttaatct atttttatta gaagtttttc     2520

tgctctttct tacataaaag aaccccaagc atgcatcttt catgtgtgta aataattcat     2580

ttctgggcta atttcaaaag aatcccaata ttgctgtata gaaagagaac tagcttgcac     2640

attttaggtc tgtgaaattt tgtgagactt ttcctgcact ggacagtaaa aaaataataa     2700

aagacaaaaa caaatttaaa aaaaaattta agccacaaaa aaaggcacat agggaattat     2760

gtcaaatgtg tttgtgtcct taggcaaagc tgtgggagtc ttgaaatgtc acagtagtaa     2820

ataacttatt actttttgac aagttctttt tttctgttgg aacactgaat tcttctgtgc     2880

atatgtacat atgaatacaa atcgaaggcc tctacctcct ggagttatac aacttggctt     2940

gtttacctcc acatgctgat gatgactatt tttttttttt gagttcagtg tggagacttg     3000

aaacttgaat gtcccttcca acttttatat taaaaataaa aagacaagaa aattgaagat     3060

catttttcac ctgtacaagg aatactaatg gatcgtctta aaattggtct aggaaaaaac     3120

cttggtgtgt gttatggaca attaactgtt aaagttattg taagttatct gtatttagca     3180

gagtattttc aacttgagtg atctgagctg aatttgaaga ctattaataa gttatgtttg     3240

gaagttttaa cttcaatgaa gtaattattt gctgtgaaag aaacaaacat tgaattacta     3300

aacaaagatg gtgcaatatc tttgtttttt ttttatgagg ctcctgagaa tcaacccaac     3360

tgaagcattt caattcactt gaatgagaaa cgtgtttagt atcaaaagag cccaagaaga     3420

cactggtgtg aaaggtacaa tctcagaggt tggtcaatta ccgtggcaca ctttctggtc     3480

actttgtaca atgtagattt gaagtacagt ggtgaaaaca ttaaatgtga catttgaaaa     3540

aaaaaaaaaa aaaaa                                                      3555


<210>  3
<211>  1746
<212>  DNA
<213>  Homo sapiens

<400>  3
cgttgtctca cccgggaagg gaaagcagcc agcagccctc cagccctctt gtgctttccc       60

tgggagtgcg ccccgtgctc agccatggtg gacatggggg ccctggacaa cctgatcgcc      120

aacaccgcct acctgcaggc ccggaagccc tcggactgcg acagcaaaga gctgcagcgg      180

cggcggcgta gcctggccct gcccgggctg cagggctgcg cggagctccg ccagaagctg      240

tccctgaact tccacagcct gtgtgagcag cagcccatcg gtcgccgcct cttccgtgac      300

ttcctagcca cagtgcccac gttccgcaag gcggcaacct tcctagagga cgtgcagaac      360

tgggagctgg ccgaggaggg acccaccaaa gacagcgcgc tgcaggggct ggtggccact      420

tgtgcgagtg cccctgcccc ggggaacccg caacccttcc tcagccaggc cgtggccacc      480

aagtgccaag cagccaccac tgaggaagag cgagtggctg cagtgacgct ggccaaggct      540

gaggccatgg ctttcttgca agagcagccc tttaaggatt tcgtgaccag cgccttctac      600

gacaagtttc tgcagtggaa actcttcgag atgcaaccag tgtcagacaa gtacttcact      660

gagttcagag tgctggggaa aggtggtttt ggggaggtat gtgccgtcca ggtgaaaaac      720

actgggaaga tgtatgcctg taagaaactg gacaagaagc ggctgaagaa gaaaggtggc      780

gagaagatgg ctctcttgga aaaggaaatc ttggagaagg tcagcagccc tttcattgtc      840

tctctggcct atgcctttga gagcaagacc catctctgcc ttgtcatgag cctgatgaat      900

gggggagacc tcaagttcca catctacaac gtgggcacgc gtggcctgga catgagccgg      960

gtgatctttt actcggccca gatagcctgt gggatgctgc acctccatga actcggcatc     1020

gtctatcggg acatgaagcc tgagaatgtg cttctggatg acctcggcaa ctgcaggtta     1080

tctgacctgg ggctggccgt ggagatgaag ggtggcaagc ccatcaccca gagggctgga     1140

accaatggtt acatggctcc tgagatccta atggaaaagg taagttattc ctatcctgtg     1200

gactggtttg ccatgggatg cagcatttat gaaatggttg ctggacgaac accattcaaa     1260

gattacaagg aaaaggtcag taaagaggat ctgaagcaaa gaactctgca agacgaggtc     1320

aaattccagc atgataactt cacagaggaa gcaaaagata tttgcaggct cttcttggct     1380

aagaaaccag agcaacgctt aggaagcaga gaaaagtctg atgatcccag gaaacatcat     1440

ttctttaaaa cgatcaactt tcctcgcctg gaagctggcc taattgaacc cccatttgtg     1500

ccagaccctt cagtggttta tgccaaagac atcgctgaaa ttgatgattt ctctgaggtt     1560

cggggggtgg aatttgatga caaagataag cagttcttca aaaactttgc gacaggtgct     1620

gttcctatag catggcagga agaaattata gaaacgggac tgtttgagga actgaatgac     1680

cccaacagac ctacgggttg tgaggagggt aattcatcca agtctggcgt gtgtttgtta     1740

ttgtaa                                                                1746


<210>  4
<211>  5694
<212>  DNA
<213>  Homo sapiens

<400>  4
gggaaggagc gaaggagcga aggagcaagc ggagcggccg tcgcccaagc caagccgcgc       60

tgccaaccct cccgcccgcc cgcgctcctg tccgccgtgt ctagcagcgg ggcccagcat      120

ggtcatggcg gatggcccga ggcacttgca gcgcgggccg gtccgggtgg ggttctacga      180

catcgagggc acgctgggca agggcaactt cgctgtggtg aagctggggc ggcaccggat      240

caccaagacg gaggtggcaa taaaaataat cgataagtct cagctggatg cagtgaacct      300

tgagaaaatc taccgagaag tacaaataat gaaaatgtta gaccaccctc acataatcaa      360

actttatcag gtaatggaga ccaaaagtat gttgtacctt gtgacagaat atgccaaaaa      420

tggagaaatt tttgactatc ttgctaatca tggccggtta aatgagtctg aagccaggcg      480

aaaattctgg caaatcctgt ctgctgttga ttattgtcat ggtcggaaga ttgtgcaccg      540

tgacctcaaa gctgaaaatc tcctgctgga taacaacatg aatatcaaaa tagcagattt      600

cggttttgga aatttcttta aaagtggtga actgctggca acatggtgtg gcagcccccc      660

ttatgcagcc ccagaagtct ttgaagggca gcagtatgaa ggaccacagc tggacatctg      720

gagtatggga gttgttcttt atgtccttgt ctgtggagct ctgccctttg atggaccgac      780

tcttccaatt ttgaggcaga gggttctgga aggaagattc cggattccgt atttcatgtc      840

agaagattgc gagcacctta tccgaaggat gttggtccta gacccatcca aacggctaac      900

catagcccaa atcaaggagc ataaatggat gctcatagaa gttcctgtcc agagacctgt      960

tctctatcca caagagcaag aaaatgagcc atccatcggg gagtttaatg agcaggttct     1020

gcgactgatg cacagccttg gaatagatca gcagaaaacc attgagtctt tgcagaacaa     1080

gagctataac cactttgctg ccatttattt cttgttggtg gagcgcctga aatcacatcg     1140

gagcagtttc ccagtggagc agagacttga tggccgccag cgtcggccta gcaccattgc     1200

tgagcaaaca gttgccaagg cacagactgt ggggctccca gtgaccatgc attcaccgaa     1260

catgaggctg ctgcgatctg ccctcctccc ccaggcatcc aacgtggagg ccttttcatt     1320

tccagcatct ggctgtcagg cggaagctgc attcatggaa gaagagtgtg tggacactcc     1380

aaaggtcaat ggctgtctgc ttgaccctgt gcctcctgtc ctggtgcgga agggatgcca     1440

gtcactgccc agcaacatga tggagacctc cattgacgaa gggctggaga cagaaggaga     1500

ggccgaggaa gaccccgctc atgcctttga ggcatttcag tccacacgca gcgggcagag     1560

acggcacact ctgtcagaag tgaccaatca actggtcgtg atgcctgggg cagggaaaat     1620

tttctccatg aatgacagcc cctcccttga cagtgtggac tctgagtatg atatggggtc     1680

tgttcagagg gacctgaact ttctggaaga caacccttcc cttaaggaca tcatgttagc     1740

caatcagcct tcaccccgca tgacatctcc cttcataagc ctgagaccta ccaacccagc     1800

catgcaggct ctgagctccc agaaacgaga ggtccacaac aggtctccag tgagcttcag     1860

agagggccgc agagcatcag atacctccct cacccaggga attgtagcat ttagacaaca     1920

tcttcagaat ctggctagaa ccaaaggaat tctagagttg aacaaagtgc agttgttgta     1980

tgaacaaata ggaccggagg cagaccctaa cctggcgccg gcggctcctc agctccagga     2040

ccttgctagc agctgccctc aggaagaagt ttctcagcag caggaaagcg tctccactct     2100

ccctgccagc gtgcatcccc agctgtcccc acggcagagc ctggagaccc agtacctgca     2160

gcacagactc cagaagccca gccttctgtc aaaggcccag aacacctgtc agctttattg     2220

caaagaacca ccgcggagcc ttgagcagca gctgcaggaa cataggctcc agcagaagcg     2280

actctttctt cagaagcagt ctcaactgca ggcctatttt aatcagatgc agatagcaga     2340

gagctcctac ccacagccaa gtcagcagct gccccttccc cgccaggaga ctccaccgcc     2400

ttctcagcag gccccaccgt tcagcctgac ccagcccctg agccccgtcc tggagccttc     2460

ctccgagcag atgcaataca gccctttcct cagccagtac caagagatgc agcttcagcc     2520

cctgccctcc acttccggtc cccgggctgc tcctcctctg cccacgcagc tacagcagca     2580

gcagccgcca ccgccaccac cccctccacc accacgacag ccaggagctg ccccagcccc     2640

cttacagttc tcctatcaga cttgtgagct gccaagcgct gcttcccctg cgccagacta     2700

tcccactccc tgtcagtatc ctgtggatgg agcccagcag agcgacctaa cggggccaga     2760

ctgtcccaga agcccaggac tgcaagaggc cccctccagc tacgacccac tagccctctc     2820

tgagctacct ggactctttg attgtgaaat gctagacgct gtggatccac aacacaacgg     2880

gtatgtcctg gtgaattagt ctcagcacag gaattgaggt gggtcaggtg aaggaagagt     2940

gtatgttcct atttttattc cagcctttta aatttaaagc ttattttctt gccctctccc     3000

taacggggag aaatcgagcc acccaactgg aatcagaggg tctggctggg gtggatgttg     3060

cttcctcctg gttctgcccc accacaaagt tttctgtggc aagtgctgga acatagttgt     3120

aggctgaggc tcctgccctt cggtcgagtg gagcaagctc tcgagggcag cactgacaaa     3180

tgtgttccta agaagacatt cagacccagg tcttatgcag gattacatcc gtttattatc     3240

aagggcaacc ttggtgaaag cagaaagggt gtgtgctatt gcatatatat gggggaaaag     3300

gcaatatatt tttcactgaa gctgagcaac cacatattgc tacaaggcaa atcaagaaga     3360

catcaggaaa tcagatgcac aggaaataaa ggaaagctgt gctttgtcat tgaatcctaa     3420

gttcttagct gctgatgcaa gttgtccccc aaggccatca caaagcagtg gggcatgagc     3480

tgtgtttcag gggccactaa ataacagctg gtactgaccc cagaaaccgc cttcatctcc     3540

attcggaagc aggtgacaca ccccttcaga aggtgccctg ggttgccgag tgtcagaata     3600

tactcaggac tccagaggtg tcacacgtgg aactgacagg agacccgcca ccgtggaggc     3660

agggggcaag aaactcaaga acgcatcaag agcaccagcc ctgggccagg gaagacaggc     3720

tcttcctgca gtttctcgtg gacactgctg gcttgcgggc agtcggtctc cagggtacct     3780

gttgtctctt ttccgatgta ataactactt tgaccttaca ctatatgttg ctagtagttt     3840

attgagcttt gtatatttgg acagtttcat atagggctta gagattttaa ggacatgata     3900

aatgaacttt tctgtcccat gtgaagtggt agtgcggtgc ctttccccca gatcatgctt     3960

taattctttc ttttctgtag aaaccaacag tttccattta tgtcaatgct aaatccaaag     4020

tcacttcaga gtttgttttc caccatgtgg gaatcagcat tcttaatttc gttaaagttt     4080

tgacttgtaa tgaaatgttc aagtattaca gcaatattca aagaaagaac cacagatgtg     4140

ttaaccattt aagcagatca tctgccaaac attatattac taataaaact taaccaacac     4200

ttacaattca gtcatcaaag taagtaaaaa ttagatgcta cagctagcta actgtatccc     4260

tagaaatgat gaataatttg ccatttggac agttaacatc caggtgttac aaagtcagtg     4320

ttaattctaa agatgatcat ttctgccctt tagaatggct tgtcccatca gcagatgaat     4380

gtgttaagca caaagcatct tccttaaagc acaaagagag ggactaactg atgctgcatc     4440

tagaaaacac ctttaagttg cctttcctct ttgtagttag cgttcaggca ggtgacgtgt     4500

ggaaagtcta gggggttcca ttctggccat gcgagcccag ctcctaccaa cgtcggtaac     4560

ttgagcagtc cctgttgctg gccagagact gcctggtcgc cagcgctcac catgggtgcc     4620

aggatgcttc gcagaggcac tgtgctcacg gttggacttg gtgtcagtgg gaaagggcag     4680

tgtggggact gtcatttttg tgatttaata acacacagtg aaaatccagg aagaatgaat     4740

taagcttctt ctgggagttg tttattcctg ctcgtgctta agattgatga tttcgtgaaa     4800

taaagaacat catttcattt aagagatcat ttcattaaga tctctaatct gttttgagtc     4860

tttacaaaat agccagttat aaaatggggc ttgatttgtt tagactgaag gaagacgttt     4920

tcccaaaata tactacagaa gtgctacaat atttgcgata ttaaaatgcc tgcagattga     4980

aaatgggggc cactcatttc agaactgcag gaatggtgta gttacagatc gacataaact     5040

cctgcccccc aacaatgcca tgagctgctt agcccaggag acctgggagc tatggcagga     5100

cggttaggcc agccgatgag ggactgcaga gaggctactg gaaggttaag gacccagaga     5160

gaaatcgaga ggtgccctac agcagccagg cctatcagga tccgtcacac acggcagcgg     5220

cgtggacacc ggcctgatgc agagcgtgac ccctcctgct gggacctgtg ttgtaagctc     5280

ctatttgctt atcttgttta tttcaagcag aaatcaataa attccataac cctctgtatt     5340

gactgcaatg taagctgctg aggagactgg ttctgttggt cagtcaggtg tttgctcagc     5400

cctgtctgat cacctgtgct gctctgtccc taactagtga cccatggaag cttccaagca     5460

gttttctctt catcactact aacaaacgaa acactaagaa ggcttagtat cgctcttttt     5520

ctgcggggct actctgaagt actgacttgc tttccagtct gattcacgtt agcagtgtgt     5580

acactactgt atcatcatca gcttcatcac cctgtaaacc aggctcctct gaagagactt     5640

tggtgagatg aacgtgaggt aaaaatttcg ttcggcaaaa aaaaaaaaaa aaaa           5694


<210>  5
<211>  2454
<212>  DNA
<213>  Homo sapiens

<400>  5
ccaggaggca cgctggtttt ccggggccgc tccatcgcgc cttcctcctg cgcctcgctt       60

ctccggtcca gccgccatct tcctttccgc acaggggccg ccgagcgggg ccatgcagcc      120

aacgctgctt ctcagcctcc tgggagccgt ggggctggcg gctgtcaatt ccatgccagt      180

ggataacagg aaccacaatg aaggaatggt gactcgctgc atcattgagg tcctctcaaa      240

tgccttgtcg aagtccagcg ctccacccat cacccctgag tgccgccaag tcctgaagac      300

gagtagaaaa gacgtcaaag acaaagagac aactgaaaat gaaaacacaa agtttgaagt      360

aagattgtta agagacccag ctgatgcctc ggaagcccac gagtcctcca gcaggggaga      420

ggcaggagcc ccaggggagg aggacatcca aggcccaaca aaggcagaca cagagaaatg      480

ggcagaggga ggcgggcaca gccgagagcg agcggatgag ccccagtgga gcctctatcc      540

ctccgacagc caagtctctg aagaagtgaa gacacgccat tctgagaaga gccagagaga      600

ggatgaggag gaggaggagg gagagaacta tcaaaaaggg gagcgagggg aagatagcag      660

tgaagagaaa caccttgaag agccaggaga gacacaaaac gcttttctca atgaaagaaa      720

gcaggcttca gctataaaaa aagaggagtt agtggccaga tcggaaacac atgctgccgg      780

gcattctcag gagaagacac atagccgaga gaagagtagc caggagagtg gagaggaggc      840

agggagccag gagaatcacc cccaggagtc taaaggccaa ccccgaagcc aggaagaatc      900

tgaggaaggt gaggaagatg ccacctctga ggtggacaaa cgacgcacga ggcccagaca      960

ccaccacggg aggagcaggc ccgacaggtc ctctcaagga gggagtcttc cctctgagga     1020

aaagggacac ccccaggagg aatctgagga gtcaaacgtc agcatggcca gtttagggga     1080

aaagagggac caccattcaa cccactacag ggcttcagag gaagaacctg aatatggaga     1140

agaaataaag ggttatccag gcgtccaggc ccctgaggac ctggagtggg agcgctatag     1200

gggcagagga agtgaagaat acagggctcc aagacctcag agtgaggaga gttgggatga     1260

ggaggacaag agaaactacc ccagcttaga gcttgataag atggcacatg gatatggtga     1320

agaaagtgag gaagagaggg gccttgagcc gggaaaggga cgccatcaca gaggcagggg     1380

aggggagcca cgtgcctatt tcatgtctga caccagagaa gagaaaaggt tcttgggtga     1440

aggacaccac cgtgtccaag aaaaccagat ggacaaggca aggaggcatc cacaaggtgc     1500

gtggaaagag ctggacagaa attatctcaa ctacggtgag gaaggagccc cagggaagtg     1560

gcagcagcag ggagacctgc aggacactaa agaaaacagg gaggaagcta ggtttcaaga     1620

taaacaatat agctcccatc acacagctga aaagaggaag agattagggg aactgttcaa     1680

cccatactac gaccctctcc agtggaagag cagccatttt gaaagaagag acaacatgaa     1740

tgacaatttt ctcgagggtg aggaggaaaa tgagctgacc ttgaacgaga agaatttctt     1800

cccagaatac aactatgact ggtgggagaa aaagcccttc tctgaggatg tgaactgggg     1860

gtatgagaag agaaacctcg ccagggtccc caagctggac ctgaaaaggc aatatgacag     1920

ggtggcccaa ctggaccagc tccttcacta caggaagaag tcagctgagt ttccagactt     1980

ctatgattct gaggagccgg tgagcaccca ccaggaggca gaaaatgaaa aggacagggc     2040

tgaccagaca gtcctgacag aggacgagaa aaaagaactc gaaaacttgg ctgcaatgga     2100

tttggaacta cagaagatag ctgagaaatt cagccaaagg ggctgactgt cattggagcg     2160

gtgggcactg ttaagaagca gccatcacat gatctgtttt tcaccacttc actgaaagac     2220

accatttata tacccaaggg cagaaagtag aacttactat tcattaaatg tttgacacaa     2280

ttggaattgt ctttaatttc tgtcagaatg ctattgaaaa tgtgaattgc atgacttgta     2340

gcatattctt ttctgcaaaa tagacatatt aacatgctta tgacaatgac tgtgctactg     2400

tctttggaaa aatgtttgtc tcagttggaa ataataaaag attcacctga gacc           2454


<210>  6
<211>  2450
<212>  DNA
<213>  Homo sapiens

<400>  6
gctgagctgg atggaccgcg agacgcgcgc cctcgccgac agccacttcc gaggcctggg       60

ggtcgatgtc cccggcgtcg gccaggctcc gggccgggta gccttcgtct cggagccggg      120

cgccttctcc tacgccgact ttgtgcgggg cttcttgctg cccaacctgc cctgcgtgtt      180

ttccagcgcc ttcacgcagg gctggggcag ccggcggcgc tgggtgacgc ccgcggggag      240

gcccgacttc gaccacctgc tacggaccta cggagacgtg gttgtaccag ttgcaaactg      300

tggggtccag gaatacaact cgaaccccaa agagcacatg actctcagag actacatcac      360

ctactggaaa gagtacatac aggcgggcta ctcctctccc aggggctgtc tctacctcaa      420

agactggcac ttgtgcaggg actttccggt ggaggacgtt ttcaccctgc ctgtgtactt      480

ctcgtccgac tggctgaatg agttctggga tgcactggat gtggatgact accgctttgt      540

ctacgcgggg cctgcgggca gctggtcccc gttccatgct gacatcttcc gctccttcag      600

ctggtctgtc aatgtctgtg ggaggaagaa gtggctcctc ttccccccag ggcaggaaga      660

ggccctgcgg gaccgccacg gcaacctgcc ctacgacgtg acctccccag cactctgcga      720

cacacacctg cacccacgga accagcttgc tggcccaccc ttggagatca cgcaggaagc      780

gggcgagatg gtgtttgtgc ccagtggctg gcaccaccag gtgcacaacc tggatgacac      840

catctccatc aaccacaact gggtcaatgg cttcaacctg gccaacatgt ggcgcttctt      900

gcagcaggag ctatgcgccg tgcaggagga ggtcagcgag tggagggact ccatgcccga      960

ctggcaccac cactgccagg tcatcatgag gtcctgctcg ggcatcaact ttgaagagtt     1020

ttaccacttc ctcaaggtca tcgctgagaa gaggctcctg gtcctgaggg aggcagccgc     1080

tgaggacggt gctgggttgg gtttcgaaca ggcagccttt gatgttgggc gcatcacaga     1140

ggtgctggcc tccttggttg cgcaccccga cttccagaga gtggacacca gcgcgttctc     1200

accacagccc aaagagctgc tgcagcagct gagagaggct gttgatgctg ctgcggcccc     1260

atagcacctg tcgtgaggat agaaggacgg gtggacgaga ggcagcctcc tgctccgggg     1320

cccttccaga aataaagacc gccctccctg tgacctgggg cccacccctg tcgaggcttg     1380

tggcctggct gttcatggcc actgcctggg tgcctgtttt caggtgaggc ccaatgaggt     1440

cagggaccca agatgggatg tggcccttct gacctgcagc aggcctgctg ggagctcgga     1500

gatggtgcca ggacctggct cttttggggg ccctgcctcc ttaggccagg acgcctgagc     1560

tgacaggagt ctgtgtctgg tgtgccttct ctggtggctc ctcttaatag gccagccctg     1620

tcccctcgtc tcaggccatt ggaccacccc tggctctgcc ctgtgggttc agggaggggt     1680

tggagcagtg ctgggcaagc tcaccagggc ctccaggcag ggctggggtt ggcctccatc     1740

acctccaggt gatgggctgt ggaaccagcg gcctgcgcct tcctctgggt acccagagtg     1800

gagggctggg ttgggctggc ctttgccacc tccctgcctt tgcagggcct gtggacagct     1860

ggagaggcca cagatggggt ggaatcccat ctgctgctga atcctcacct gggcctgagg     1920

gactgtgcct gctgtgcact cacagctggg tcttcccaag gatgctgttc tcaggagtgg     1980

tgggtcccca gcccctcttc acactgggta tgatggaggt gtgggcgggc tcgtccaggc     2040

cgatcaaggc acagcagtga gcagcggagg cctgtggtgg ggaatggact ctcgtgggat     2100

cctcttgcag aggatgcccc aggcctgaac cctctagtgg atccacagtt tgtggagact     2160

ggcactctcc cagccctgtc cttgaccgag aatccagcat tttttcagtt ggcccctggt     2220

tggctgcctc accccagcag gggaggaggc atccgaatcc acagggacgg cacgtgccat     2280

ggctatgcac attgcctgcc cgtggcatca actggggccg ctggcacttg tctaggatgg     2340

aagcccccaa gaagggcagg ggtttctgtc tgctctgttc agtgaatcat gtgaagtgct     2400

tgcaaaggca gctttacaca gtaggtgctt caaaaaaaaa aaaaaaaaaa                2450


<210>  7
<211>  7852
<212>  DNA
<213>  Homo sapiens

<400>  7
ggcgctgagc gagctcggag cccgcgctgt gcgcctgcgg ccggggcgcc ccgccgagcg       60

ccggtgcccc ggctcccggg ccgccttcgc cgcgcgggaa ggattcttca aaattaacag      120

aaaccaattc gggccagctg aagagaaaaa ataaaggtgg ctcccggctg cctctgctgc      180

agttcagagc aacttcagga gcttcccagc cgagagcttc aggacgcctt tcctgtccca      240

ctggcccagt tgccacaaca aacaacagag aagacggtga ccatggggga tgtgaagctg      300

gttgcctcgt cacacatttc caaaacctcc ctcagtgtgg atccctcaag agttgactcc      360

atgcccctga cagaggcccc tgctttcatt ttgccccctc ggaacctctg catcaaagaa      420

ggagccaccg ccaagttcga agggcgggtc cggggttacc cagagcccca ggtgacatgg      480

cacagaaacg ggcaacccat caccagcggg ggccgcttcc tgctggattg cggcatccgg      540

gggactttca gccttgtgat tcatgctgtc catgaggagg acaggggaaa gtatacctgt      600

gaagccacca atggcagtgg tgctcgccag gtgacagtgg agttgacagt agaaggaagt      660

tttgcgaagc agcttggtca gcctgttgtt tccaaaacct taggggatag attttcagct      720

ccagcagtgg agacccgtcc tagcatctgg ggggagtgcc caccaaagtt tgctaccaag      780

ctgggccgag ttgtggtcaa agaaggacag atgggacgat tctcctgcaa gatcactggc      840

cggccccaac cgcaggtcac ctggctcaag ggaaatgttc cactgcagcc gagtgcccgt      900

gtgtctgtgt ctgagaagaa cggcatgcag gttctggaaa tccatggagt caaccaagat      960

gacgtgggag tgtacacgtg cctggtggtg aacgggtcgg ggaaggcctc gatgtcagct     1020

gaactttcca tccaaggttt ggacagtgcc aataggtcat ttgtgagaga aacaaaagcc     1080

accaattcag atgtcaggaa agaggtgacc aatgtaatct caaaggagtc gaagctggac     1140

agtctggagg ctgcagccaa aagcaagaac tgctccagcc cccagagagg tggctcccca     1200

ccctgggctg caaacagcca gcctcagccc ccaagggagt ccaagctgga gtcatgcaag     1260

gactcgccca gaacggcccc gcagaccccg gtccttcaga agacttccag ctccatcacc     1320

ctgcaggccg caagagttca gccggaacca agagcaccag gcctgggggt cctatcacct     1380

tctggagaag agaggaagag gccagctcct ccccgtccag ccaccttccc caccaggcag     1440

cctggcctgg ggagccaaga tgttgtgagc aaggctgcta acaggagaat ccccatggag     1500

ggccagaggg attcagcatt ccccaaattt gagagcaagc cccaaagcca ggaggtcaag     1560

gaaaatcaaa ctgtcaagtt cagatgtgaa gtttccggga ttccaaagcc tgaagtggcc     1620

tggttcctgg aaggcacccc cgtgaggaga caggaaggca gcattgaggt ttatgaagat     1680

gctggctccc attacctctg cctgctgaaa gcccggacca gggacagtgg gacatacagc     1740

tgcactgctt ccaacgccca aggccagctg tcctgtagct ggaccctcca agtggaaagg     1800

cttgccgtga tggaggtggc cccctccttc tccagtgtcc tgaaggactg cgctgttatt     1860

gagggccagg attttgtgct gcagtgctcc gtacggggga ccccagtgcc ccggatcact     1920

tggctgctga atgggcagcc catccagtac gctcgctcca cctgcgaggc cggcgtggct     1980

gagctccaca tccaggatgc cctgccggag gaccatggca cctacacctg cctagctgag     2040

aatgccttgg ggcaggtgtc ctgcagcgcc tgggtcaccg tccatgaaaa gaagagtagc     2100

aggaagagtg agtaccttct gcctgtggct cccagcaagc ccactgcacc catcttcctg     2160

cagggcctct ctgatctcaa agtcatggat ggaagccagg tcactatgac tgtccaagtg     2220

tcagggaatc caccccctga agtcatctgg ctgcacaatg ggaatgagat ccaagagtca     2280

gaggacttcc actttgaaca gagaggaact cagcacagcc tttgtatcca ggaagtgttc     2340

ccggaggaca cgggcacgta cacctgcgag gcctggaaca gcgctggaga ggtccgcacc     2400

caggccgtgc tcacggtaca agagcctcac gatggcaccc agccctggtt catcagtaag     2460

cctcgctcag tgacagcctc cctgggccag agtgtcctca tctcctgcgc catagctggt     2520

gacccctttc ctaccgtgca ctggctcaga gatggcaaag ccctctgcaa agacactggc     2580

cacttcgagg tgcttcagaa tgaggacgtg ttcaccctgg ttctaaagaa ggtgcagccc     2640

tggcatgccg gccagtatga gatcctgctc aagaaccggg ttggcgaatg cagttgccag     2700

gtgtcactga tgctacagaa cagctctgcc agagcccttc cacgggggag ggagcctgcc     2760

agctgcgagg acctctgtgg tggaggagtt ggtgctgatg gtggtggtag tgaccgctat     2820

gggtccctga ggcctggctg gccagcaaga gggcagggtt ggctagagga ggaagacggc     2880

gaggacgtgc gaggggtgct gaagaggcgc gtggagacga ggcagcacac tgaggaggcg     2940

atccgccagc aggaggtgga gcagctggac ttccgagacc tcctggggaa gaaggtgagt     3000

acaaagaccc tatcggaaga cgacctgaag gagatcccag ccgagcagat ggatttccgt     3060

gccaacctgc agcggcaagt gaagccaaag actgtgtctg aggaagagag gaaggtgcac     3120

agcccccagc aggtcgattt tcgctctgtc ctggccaaga aggggacttc caagaccccc     3180

gtgcctgaga aggtgccacc gccaaaacct gccaccccgg attttcgctc agtgctgggt     3240

ggcaagaaga aattaccagc agagaatggc agcagcagtg ccgagaccct gaatgccaag     3300

gcagtggaga gttccaagcc cctgagcaat gcacagcctt cagggccctt gaaacccgtg     3360

ggcaacgcca agcctgctga gaccctgaag ccaatgggca acgccaagcc tgccgagacc     3420

ctgaagccca tgggcaatgc caagcctgat gagaacctga aatccgctag caaagaagaa     3480

ctcaagaaag acgttaagaa tgatgtgaac tgcaagagag gccatgcagg gaccacagat     3540

aatgaaaaga gatcagagag ccaggggaca gccccagcct tcaagcagaa gctgcaagat     3600

gttcatgtgg cagagggcaa gaagctgctg ctccagtgcc aggtgtcttc tgacccccca     3660

gccaccatca tctggacgct gaacggaaag accctcaaga ccaccaagtt catcatcctc     3720

tcccaggaag gctcactctg ctccgtctcc atcgagaagg cactgcctga ggacagaggc     3780

ttatacaagt gtgtagccaa gaatgacgct ggccaggcgg agtgctcctg ccaagtcacc     3840

gtggatgatg ctccagccag tgagaacacc aaggccccag agatgaaatc ccggaggccc     3900

aagagctctc ttcctcccgt gctaggaact gagagtgatg cgactgtgaa aaagaaacct     3960

gcccccaaga cacctccgaa ggcagcaatg ccccctcaga tcatccagtt ccctgaggac     4020

cagaaggtac gcgcaggaga gtcagtggag ctgtttggca aagtgacagg cactcagccc     4080

atcacctgta cctggatgaa gttccgaaag cagatccagg aaagcgagca catgaaggtg     4140

gagaacagcg agaatggcag caagctcacc atcctggccg cgcgccagga gcactgcggc     4200

tgctacacac tgctggtgga gaacaagctg ggcagcaggc aggcccaggt caacctcact     4260

gtcgtggata agccagaccc cccagctggc acaccttgtg cctctgacat tcggagctcc     4320

tcactgaccc tgtcctggta tggctcctca tatgatgggg gcagtgctgt acagtcctac     4380

agcatcgaga tctgggactc agccaacaag acgtggaagg aactagccac atgccgcagc     4440

acctctttca acgtccagga cctgctgcct gaccacgaat ataagttccg tgtacgtgca     4500

atcaacgtgt atggaaccag tgagccaagc caggagtctg aactcacaac ggtaggagag     4560

aaacctgaag agccgaagga tgaagtggag gtgtcagatg atgatgagaa ggagcccgag     4620

gttgattacc ggacagtgac aatcaatact gaacaaaaag tatctgactt ctacgacatt     4680

gaggagagat taggatctgg gaaatttgga caggtctttc gacttgtaga aaagaaaact     4740

cgaaaagtct gggcagggaa gttcttcaag gcatattcag caaaagagaa agagaatatc     4800

cggcaggaga ttagcatcat gaactgcctc caccacccta agctggtcca gtgtgtggat     4860

gcctttgaag aaaaggccaa catcgtcatg gtcctggaga tcgtgtcagg aggggagctg     4920

tttgagcgca tcattgacga ggactttgag ctgacggagc gtgagtgcat caagtacatg     4980

cggcagatct cggagggagt ggagtacatc cacaagcagg gcatcgtgca cctggacctc     5040

aagccggaga acatcatgtg tgtcaacaag acgggcacca ggatcaagct catcgacttt     5100

ggtctggcca ggaggctgga gaatgcgggg tctctgaagg tcctctttgg caccccagaa     5160

tttgtggctc ctgaagtgat caactatgag cccatcggct acgccacaga catgtggagc     5220

atcggggtca tctgctacat cctagtcagt ggcctttccc ccttcatggg agacaacgat     5280

aacgaaacct tggccaacgt tacctcagcc acctgggact tcgacgacga ggcattcgat     5340

gagatctccg acgatgccaa ggatttcatc agcaatctgc tgaagaaaga tatgaaaaac     5400

cgcctggact gcacgcagtg ccttcagcat ccatggctaa tgaaagatac caagaacatg     5460

gaggccaaga aactctccaa ggaccggatg aagaagtaca tggcaagaag gaaatggcag     5520

aaaacgggca atgctgtgag agccattgga agactgtcct ctatggcaat gatctcaggg     5580

ctcagtggca ggaaatcctc aacagggtca ccaaccagcc cgctcaatgc agaaaaacta     5640

gaatctgaag aagatgtgtc ccaagctttc cttgaggctg ttgctgagga aaagcctcat     5700

gtaaaaccct atttctctaa gaccattcgc gatttagaag ttgtggaggg aagtgctgct     5760

agatttgact gcaagattga aggataccca gaccccgagg ttgtctggtt caaagatgac     5820

cagtcaatca gggagtcccg ccacttccag atagactacg atgaggacgg gaactgctct     5880

ttaattatta gtgatgtttg cggggatgac gatgccaagt acacctgcaa ggctgtcaac     5940

agtcttggag aagccacctg cacagcagag ctcattgtgg aaacgatgga ggaaggtgaa     6000

ggggaagggg aagaggaaga agagtgaaac aaagccagag aaaagcagtt tctaagtcat     6060

attaaaagga ctatttctct aaaactcaaa aaaaaaaaaa aaactcaaga tagtaaaagc     6120

acctagtgtg atagattatc ggttaggtca tttgtgggtt gattcttcag aaacagcagt     6180

tgatacctag cagcgttatt gatgggcatt aatctatgtt agttggcacc ttaagatact     6240

agtgcagcta gatttcattt agggaaatca ccagtaactt gactgaccaa ttgattttag     6300

agagaaagta accaaaccaa atatttatct gggcaaagtc ataaattctc cacttgaatg     6360

cgctcatgaa aaataaggcc aaaacaagag ttctgggcca cagctcagcc cagagggttc     6420

ctggggatgg gaggcctctc tctccccacc ccctgactct agagaactgg gttttctccc     6480

agtactccag caattcattt ctgaaagcag ttgagccact ttattccaaa gtacactgca     6540

gatgttcaaa ctctccattt ctctttcccc ttccacctgc cagttttgct gactctcaac     6600

ttgtcatgag tgtaagcatt aaggacatta tgcttcttcg attctgaaga caggtccctg     6660

ctcatggatg actctggctt ccttaggaaa atatttttct tccaaaatca gtaggaaatc     6720

taaacttatc ccctctttgc agatgtctag cagcttcaga catttggtta agaacccatg     6780

ggaaaaaaaa aatccttgct aatgtggttt cctttgtaaa ccaggattct tatttgtgct     6840

gttatagaat atcagctctg aacgtgtggt aaagattttt gtgtttgaat ataggagaaa     6900

tcagtttgct gaaaagttag tcttaattat ctattggcca cgatgaaaca gatttcaact     6960

gataaagagc tggagaactc catgtacttt ggaatctcct ccaagatagc cagagtttaa     7020

tacatcttca ttctcaacac tctccaaaga acttgaccta ccttatgggt tccatatttt     7080

tcttcttaaa tgtgcatcaa tcatgccttg cccccaacct ttaaatatat tcttagacct     7140

ggtaaatgca ctcagacttg cgtctttagg aatttttaac tttctttcac tacattggca     7200

cttaaatttt ttctttataa agctttttga aggtcataaa caaagaccat aattgatgat     7260

agacctaata catttcctct gtgtgtgtgt gtaacattcc aaatactttt tttttctttt     7320

ccactgtttg taaggtgcaa caatttaata tttttaaggg actttttaag agttccttaa     7380

gaaccaattt aaaattactt cagtgcaatc ctacacagta tcaacattag aattttgata     7440

ttagtcttat gttatcttcc attctatttt tatctgcttt ttgctgctag tttcaaactg     7500

ccagtatttt tccttttgct tttaaaatag ttacaatatt tttcatgata gccacagtat     7560

tgccacagtt tattataata aagggttttt atttgattta gcgcattcaa agcttttttc     7620

tatcactttt gtgttcagaa tataaccttt gtgtgcgtgt atgttgtgtg tgtgcatgtg     7680

tggcgtatat gtgtgttaca ggttaatgcc ttcttggaat tgtgttaatg ttctcttggt     7740

ttattatgcc atcagaatgg taaatgagaa cactacaact gtagtcagct cacaattttt     7800

aaataaagga taccacagtg catgctgttt gttcaaaaaa aaaaaaaaaa aa             7852


<210>  8
<211>  1594
<212>  DNA
<213>  Homo sapiens

<400>  8
ccctcctctt cctgttcttg gtcaattccg gtcttgtttc cccaacaaat gccgtcgttt       60

ccggggctgc ttccgagccg gacccaaggg ccggggcgtg gaggagtaga ggggcgagcg      120

catgcgcaca ggactacacg tcccgacagg cgtcgggagc ggcggcccag ttccttgtgg      180

gagctgtagt tctgcaggcg cggaagccgt ggtgctcggc cggcagagca ctcggtttcc      240

cagagggctg agcgcgccgc acggaggtgc ggcgccgacc aagatggaga ctgccgagca      300

gccttgagcc gttgagcagc tgaacagagg ccatgccggg gcactccgag gcctgagacg      360

accacgcctg tgccgctgag gaccttcatc agggctccgt ccacttggcc cgcttggctg      420

tccaatcaca ctccagtgtc aaccactggc acccagcagc caagagaggt gtggcgtggc      480

cctggggacg catggctgag gcaggaacag gcctcctccc agccacggtg cagccattcc      540

atctgagagg catgagctcc accttctccc agcgcagccg tgacatcttt gactgcctgg      600

agggggcggc cagacgggct ccatcctctg tggcccacac cagcatgagt gacaacggag      660

gcttcaagcg gcccctagcg ccctcaggcc ggtctccagt ggaaggcctg ggcagggccc      720

atcggagccc tgcctcacca agggtgcctc cggtccccga ctacgtggca caccccgagc      780

gctggaccaa gtacagcctg gaagatgtga ccgaggtcag cgagcagagc aatcaggcca      840

ccgccctggc cttcctgggc tcccagagcc tggctgcccc cactgactgc gtgtcctcct      900

tcaaccagga tccctccagc tgtggggagg ggagggtcat cttcaccaaa ccagtccgag      960

gggtcgaagc cagacacgag aggaagaggg tcctggggaa ggtgggagag ccaggcaggg     1020

gcggccttgg gaatcctgcc acagacaggg gcgagggccc tgtggagctg gcccatctgg     1080

ccgggcccgg gagcccagag gctgaggagt ggggcagccc ccatggaggc ctgcaggagg     1140

tggaggcact gtcagggtct gtccacagtg ggtctgtgcc aggtctcccg ccggtggaaa     1200

ctgttggctt ccatggcagc aggaagcgga gtcgagacca cttccggaac aagagcagca     1260

gccccgagga cccaggtgct gaggtctgag agggagatgg cccagcctga ccccactggc     1320

cactgccatc ctgctgcctt cccagtgggg ctggtcaggg ggcagcctgg ccactgccta     1380

gctggaatgg gaggaagcct gcaggtggca ccggtggccc tggctgcagt tctgggcagc     1440

atcctcccaa gcagagacct tgctgaagct cctggggtgt ggggtgtggg ctggaagcac     1500

tggctccctg gtagggacaa taaaggtttt gggtctttct gaaaaaaaaa aaaaaaaaaa     1560

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaa                                 1594


<210>  9
<211>  1844
<212>  DNA
<213>  Homo sapiens

<400>  9
agcggagact tctgcgtcgc ggaagcgggt cccgcaggtc gccacggttg ggggaaacgc       60

ggcggacgcc gcccccgtcc cgaaggggac tcgaaaatgt acagccagcg gtttggcacc      120

gtacagcggg aggttaaggg ccccaccccc aaagtggtga tcgtgagatc caagcctcct      180

aaaggccaag gagctgagca ccatctagaa agaatccgac gcagccatca gaagcataat      240

gctattttgg cttccattaa gtcaagtgag cgggatcgct tgaaagctga gtgggaccag      300

cacaatgact gcaagatttt ggacagcctt gtgcgagcaa gaatcaagga tgctgtgcaa      360

gggtttatca ttaacattga agaaagacga aataagctac gtgagctttt agcattagaa      420

gaaaatgagt attttacaga aatgcaattg aagaaagaaa ccattgagga gaaaaaagat      480

aggatgagag agaaaactaa attactaaaa gagaagaatg aaaaagagag gcaggatttt      540

gtggctgaaa agctagacca gcaattcagg gaacgctgtg aggagctccg tgttgaattg      600

ttatctatcc atcagaagaa ggtgtgtgag gagcggaaag cacagattgc atttaatgag      660

gagctgagca ggcaaaagct ggtggaagag cagatgttct ccaaactctg ggaggaagac      720

cgattagcca aggaaaagcg agaagcccaa gaggcgagga gacagaaaga gctgatggag      780

aacacacgcc tggggctgaa tgcccagatc accagcatca aggcacaaag gcaggcgaca      840

cagctgctga aggaagagga ggcacgcctt gtggaaagta acaacgcaca gattaaacat      900

gagaatgaac aggatatgct aaagaaacag aaggcaaagc aggaaactag gaccattttg      960

caaaaagccc tacaagagag gatagaacat attcagcagg aatacagaga cgaacaggac     1020

ttgaacatga agctcgtgca aagggccctt caagacttac aggaagaggc agataaaaag     1080

aaacaaaaaa gagaagatat gataagagaa cagaagatat accataaata tttggcacag     1140

agacgtgagg aagaaaaagc tcaggagaaa gaatttgaca gaatattaga ggaagacaag     1200

gcaaagaagt tggctgagaa ggacaaggag ctgagacttg aaaaggaggc aaggagacag     1260

cttgtggatg aggtcatgtg tacaagaaaa cttcaagttc aagaaaagtt gcaacgagaa     1320

gctaaagaac aggaagaacg tgctatggaa cagaaacaca taaatgaaag tcttaaagaa     1380

cttaactgtg aagagaagga gaattttgca agacgccaac gtttagccca ggagtacagg     1440

aagcaacttc agatgcaaat cgcctaccag cagcagtccc aagaagcaga gaaggaagag     1500

aaacgccgag agtttgaagc aggtgtagca gcaaacaaga tgtgtttgga caaggtccag     1560

gaggtcctgt ccacccatca agtgctgcct caaaacattc atcccatgcg caaggcatgc     1620

cccagtaagc ttccaccgta gttccgtgag catcaatata tcttttcttg gtcttttaat     1680

atttttaact acagtatgct tgtatgcttc ttttaactcc tggataaact tttctttttt     1740

ccctgagttt gtgtaattaa ttgaacataa ttttcttcct ttgaataaac ctgtgcctat     1800

tttggagttc acagacttac aaatccaaaa aaaaaaaaaa aaca                      1844


<210>  10
<211>  3029
<212>  DNA
<213>  Homo sapiens

<400>  10
ccgcagagag gtgtggtcag ggacatttcc cctggccggg agcccatgga gcactgtcct       60

cagagatgcg caggttaggc tcactgtcta ggccaggccc accttagtca ctgtggactg      120

gcaatggaag ctcttcctgg acacacctgc cctagccctc accctggggt ggaagagaaa      180

tgagcttggc ttgcaactca gaccattcca cggaggcatc ctccccttcc tgggctggtg      240

aataaaagtt tcctgaggtc aaggacttcc ttttccctgc caaaatggtg tccagaactt      300

tgaggccaga ggtgatccag tgatttggga gctgcaggtc acacaggctg ctcagagggc      360

tgctgaacag gatgtcctcg gacgacaggc acctgggctc cagctgcggc tccttcatca      420

agactgagcc gtccagcccg tcctcgggca tcgatgccct cagccaccac agccccagtg      480

gctcgtccga cgccagcggc ggctttggcc tggccctggg cacccacgcc aacggtctgg      540

actcgccacc catgtttgca ggcgccgggc tgggaggcac cccatgccgc aagagctacg      600

aggactgtgc cagcggcatc atggaggact cggccatcaa gtgcgagtac atgctcaacg      660

ccatccccaa gcgcctgtgc ctcgtgtgcg gggacattgc ctctggctac cactacggcg      720

tggcctcctg cgaggcttgc aaggccttct tcaagaggac tatccaaggg aacattgagt      780

acagctgccc ggccaccaac gagtgcgaga tcaccaaacg gaggcgcaag tcctgccagg      840

cctgccgctt catgaaatgc ctcaaagtgg ggatgctgaa ggaaggtgtg cgccttgatc      900

gagtgcgtgg aggccgtcag aaatacaagc gacggctgga ctcagagagc agcccatacc      960

tgagcttaca aatttctcca cctgctaaaa agccattgac caagattgtc tcatacctac     1020

tggtggctga gccggacaag ctctatgcca tgcctccccc tggtatgcct gagggggaca     1080

tcaaggccct gaccactctc tgtgacctgg cagaccgaga gcttgtggtc atcattggct     1140

gggccaagca catcccaggc ttctcaagcc tctccctggg ggaccagatg agcctgctgc     1200

agagtgcctg gatggaaatc ctcatcctgg gcatcgtgta ccgctcgctg ccctatgacg     1260

acaagctggt gtacgctgag gactacatca tggatgagga gcactcccgc ctcgcggggc     1320

tgctggagct ctaccgggcc atcctgcagc tggtacgcag gtacaagaag ctcaaggtgg     1380

agaaggagga gtttgtgacg ctcaaggccc tggccctcgc caactccgat tccatgtaca     1440

tcgaggatct agaggctgtc cagaagctgc aggacctgct gcacgaggca ctgcaggact     1500

acgagctgag ccagcgccat gaggagccct ggaggacggg caagctgctg ctgacactgc     1560

cgctgctgcg gcagacggcc gccaaggccg tgcagcactt ctatagcgtc aaactgcagg     1620

gcaaagtgcc catgcacaaa ctcttcctgg agatgctgga ggccaaggtt ggccaagagc     1680

agcttagagg atctcccaag gatgaaagaa tgtcaagcca tgatggaaaa tgccccttcc     1740

aatcagctgc cttcacaagc agggatcaga gcaactcccc ggggatcccc aatccacgcc     1800

cttctagtcc aacccccctc aatgagagag gcaggcagat ctcacccagc actaggacac     1860

caggaggcca gggaaagcat ctctggctca ccatgtaaca tctggcttgg agcaagtggg     1920

tgttctgcac accaggcagc tgcacctcac tggatctagt gttgctgcga gtgacctcac     1980

ttcagagccc ctctagcaga gtggggcgga agtcctgatg gttggtgtcc atgaggtgga     2040

agctgctttt atacttaaaa ctcagatcac aacaggaaat gtgtcagtaa caatggaact     2100

ccatccaatg ggaaagttcc tggtactgaa ggggtccatt ggacactcag aaaagaagtt     2160

caggggccaa cttcttagct ggaatcctgg ccagatgagg accctctccg gggaagggag     2220

aggactgact tagtggaagg tggtgaagtg aggagagttt aggggaacct tcccccagtg     2280

gaacagatct caagtttacc ctaaacctgc catttctgga aaatctgtaa agaggaaaca     2340

gcctgtctca gctgtactct catgatacag gtcatttgaa atgaaccaag aaataaaaca     2400

tgaaaatcca accatggaga aggtggtatg gctgggtttt gtttggtccc cttgtcctta     2460

tacgttctaa agtttccaga ctggctttgt cactttgtga actcgtcatg tgtgaaaacc     2520

aatctttgca tatagggaac ttcctcgggc cacactttaa gaaccaagta agaggctctc     2580

aagactccag cagagtcggg aggccatggc agcgccttag aggagctgga acctgcaccc     2640

acctgtgtcg gtgggggggg cctcctttcc ccatagactc tgccctccct ctgtgcagat     2700

ggaagtggca ggggagggtg accagcttgt gacaagaaga ctgaagggtc cagagtccat     2760

gctcacggaa cagcaccaaa gaaaagcact atgtggaaag attgttttat tttctaataa     2820

tgataatatg gctggaatgg cttcttaaga tgtatatatt ttttaaaatg gcagttcccc     2880

attgcagcat cacctacttg tatgtctttc tgcctctgta tatgttctcc cagaaacccc     2940

catgtaaatc aaatgcccta ggatgcttcc atcctggtcc catgtatctg gaatctaata     3000

aataaggaaa ggaaaaaaaa aaaaaaaaa                                       3029


<210>  11
<211>  5616
<212>  DNA
<213>  Homo sapiens

<400>  11
ccccggcgca gcgcggccgc agcagcctcc gccccccgca cggtgtgagc gcccgacgcg       60

gccgaggcgg ccggagtccc gagctagccc cggcggccgc cgccgcccag accggacgac      120

aggccacctc gtcggcgtcc gcccgagtcc ccgcctcgcc gccaacgcca caaccaccgc      180

gcacggcccc ctgactccgt ccagtattga tcgggagagc cggagcgagc tcttcgggga      240

gcagcgatgc gaccctccgg gacggccggg gcagcgctcc tggcgctgct ggctgcgctc      300

tgcccggcga gtcgggctct ggaggaaaag aaagtttgcc aaggcacgag taacaagctc      360

acgcagttgg gcacttttga agatcatttt ctcagcctcc agaggatgtt caataactgt      420

gaggtggtcc ttgggaattt ggaaattacc tatgtgcaga ggaattatga tctttccttc      480

ttaaagacca tccaggaggt ggctggttat gtcctcattg ccctcaacac agtggagcga      540

attcctttgg aaaacctgca gatcatcaga ggaaatatgt actacgaaaa ttcctatgcc      600

ttagcagtct tatctaacta tgatgcaaat aaaaccggac tgaaggagct gcccatgaga      660

aatttacagg aaatcctgca tggcgccgtg cggttcagca acaaccctgc cctgtgcaac      720

gtggagagca tccagtggcg ggacatagtc agcagtgact ttctcagcaa catgtcgatg      780

gacttccaga accacctggg cagctgccaa aagtgtgatc caagctgtcc caatgggagc      840

tgctggggtg caggagagga gaactgccag aaactgacca aaatcatctg tgcccagcag      900

tgctccgggc gctgccgtgg caagtccccc agtgactgct gccacaacca gtgtgctgca      960

ggctgcacag gcccccggga gagcgactgc ctggtctgcc gcaaattccg agacgaagcc     1020

acgtgcaagg acacctgccc cccactcatg ctctacaacc ccaccacgta ccagatggat     1080

gtgaaccccg agggcaaata cagctttggt gccacctgcg tgaagaagtg tccccgtaat     1140

tatgtggtga cagatcacgg ctcgtgcgtc cgagcctgtg gggccgacag ctatgagatg     1200

gaggaagacg gcgtccgcaa gtgtaagaag tgcgaagggc cttgccgcaa agtgtgtaac     1260

ggaataggta ttggtgaatt taaagactca ctctccataa atgctacgaa tattaaacac     1320

ttcaaaaact gcacctccat cagtggcgat ctccacatcc tgccggtggc atttaggggt     1380

gactccttca cacatactcc tcctctggat ccacaggaac tggatattct gaaaaccgta     1440

aaggaaatca cagggttttt gctgattcag gcttggcctg aaaacaggac ggacctccat     1500

gcctttgaga acctagaaat catacgcggc aggaccaagc aacatggtca gttttctctt     1560

gcagtcgtca gcctgaacat aacatccttg ggattacgct ccctcaagga gataagtgat     1620

ggagatgtga taatttcagg aaacaaaaat ttgtgctatg caaatacaat aaactggaaa     1680

aaactgtttg ggacctccgg tcagaaaacc aaaattataa gcaacagagg tgaaaacagc     1740

tgcaaggcca caggccaggt ctgccatgcc ttgtgctccc ccgagggctg ctggggcccg     1800

gagcccaggg actgcgtctc ttgccggaat gtcagccgag gcagggaatg cgtggacaag     1860

tgcaaccttc tggagggtga gccaagggag tttgtggaga actctgagtg catacagtgc     1920

cacccagagt gcctgcctca ggccatgaac atcacctgca caggacgggg accagacaac     1980

tgtatccagt gtgcccacta cattgacggc ccccactgcg tcaagacctg cccggcagga     2040

gtcatgggag aaaacaacac cctggtctgg aagtacgcag acgccggcca tgtgtgccac     2100

ctgtgccatc caaactgcac ctacggatgc actgggccag gtcttgaagg ctgtccaacg     2160

aatgggccta agatcccgtc catcgccact gggatggtgg gggccctcct cttgctgctg     2220

gtggtggccc tggggatcgg cctcttcatg cgaaggcgcc acatcgttcg gaagcgcacg     2280

ctgcggaggc tgctgcagga gagggagctt gtggagcctc ttacacccag tggagaagct     2340

cccaaccaag ctctcttgag gatcttgaag gaaactgaat tcaaaaagat caaagtgctg     2400

ggctccggtg cgttcggcac ggtgtataag ggactctgga tcccagaagg tgagaaagtt     2460

aaaattcccg tcgctatcaa ggaattaaga gaagcaacat ctccgaaagc caacaaggaa     2520

atcctcgatg aagcctacgt gatggccagc gtggacaacc cccacgtgtg ccgcctgctg     2580

ggcatctgcc tcacctccac cgtgcagctc atcacgcagc tcatgccctt cggctgcctc     2640

ctggactatg tccgggaaca caaagacaat attggctccc agtacctgct caactggtgt     2700

gtgcagatcg caaagggcat gaactacttg gaggaccgtc gcttggtgca ccgcgacctg     2760

gcagccagga acgtactggt gaaaacaccg cagcatgtca agatcacaga ttttgggctg     2820

gccaaactgc tgggtgcgga agagaaagaa taccatgcag aaggaggcaa agtgcctatc     2880

aagtggatgg cattggaatc aattttacac agaatctata cccaccagag tgatgtctgg     2940

agctacgggg tgaccgtttg ggagttgatg acctttggat ccaagccata tgacggaatc     3000

cctgccagcg agatctcctc catcctggag aaaggagaac gcctccctca gccacccata     3060

tgtaccatcg atgtctacat gatcatggtc aagtgctgga tgatagacgc agatagtcgc     3120

ccaaagttcc gtgagttgat catcgaattc tccaaaatgg cccgagaccc ccagcgctac     3180

cttgtcattc agggggatga aagaatgcat ttgccaagtc ctacagactc caacttctac     3240

cgtgccctga tggatgaaga agacatggac gacgtggtgg atgccgacga gtacctcatc     3300

ccacagcagg gcttcttcag cagcccctcc acgtcacgga ctcccctcct gagctctctg     3360

agtgcaacca gcaacaattc caccgtggct tgcattgata gaaatgggct gcaaagctgt     3420

cccatcaagg aagacagctt cttgcagcga tacagctcag accccacagg cgccttgact     3480

gaggacagca tagacgacac cttcctccca gtgcctgaat acataaacca gtccgttccc     3540

aaaaggcccg ctggctctgt gcagaatcct gtctatcaca atcagcctct gaaccccgcg     3600

cccagcagag acccacacta ccaggacccc cacagcactg cagtgggcaa ccccgagtat     3660

ctcaacactg tccagcccac ctgtgtcaac agcacattcg acagccctgc ccactgggcc     3720

cagaaaggca gccaccaaat tagcctggac aaccctgact accagcagga cttctttccc     3780

aaggaagcca agccaaatgg catctttaag ggctccacag ctgaaaatgc agaataccta     3840

agggtcgcgc cacaaagcag tgaatttatt ggagcatgac cacggaggat agtatgagcc     3900

ctaaaaatcc agactctttc gatacccagg accaagccac agcaggtcct ccatcccaac     3960

agccatgccc gcattagctc ttagacccac agactggttt tgcaacgttt acaccgacta     4020

gccaggaagt acttccacct cgggcacatt ttgggaagtt gcattccttt gtcttcaaac     4080

tgtgaagcat ttacagaaac gcatccagca agaatattgt ccctttgagc agaaatttat     4140

ctttcaaaga ggtatatttg aaaaaaaaaa aaagtatatg tgaggatttt tattgattgg     4200

ggatcttgga gtttttcatt gtcgctattg atttttactt caatgggctc ttccaacaag     4260

gaagaagctt gctggtagca cttgctaccc tgagttcatc caggcccaac tgtgagcaag     4320

gagcacaagc cacaagtctt ccagaggatg cttgattcca gtggttctgc ttcaaggctt     4380

ccactgcaaa acactaaaga tccaagaagg ccttcatggc cccagcaggc cggatcggta     4440

ctgtatcaag tcatggcagg tacagtagga taagccactc tgtcccttcc tgggcaaaga     4500

agaaacggag gggatggaat tcttccttag acttactttt gtaaaaatgt ccccacggta     4560

cttactcccc actgatggac cagtggtttc cagtcatgag cgttagactg acttgtttgt     4620

cttccattcc attgttttga aactcagtat gctgcccctg tcttgctgtc atgaaatcag     4680

caagagagga tgacacatca aataataact cggattccag cccacattgg attcatcagc     4740

atttggacca atagcccaca gctgagaatg tggaatacct aaggatagca ccgcttttgt     4800

tctcgcaaaa acgtatctcc taatttgagg ctcagatgaa atgcatcagg tcctttgggg     4860

catagatcag aagactacaa aaatgaagct gctctgaaat ctcctttagc catcacccca     4920

accccccaaa attagtttgt gttacttatg gaagatagtt ttctcctttt acttcacttc     4980

aaaagctttt tactcaaaga gtatatgttc cctccaggtc agctgccccc aaaccccctc     5040

cttacgcttt gtcacacaaa aagtgtctct gccttgagtc atctattcaa gcacttacag     5100

ctctggccac aacagggcat tttacaggtg cgaatgacag tagcattatg agtagtgtgg     5160

aattcaggta gtaaatatga aactagggtt tgaaattgat aatgctttca caacatttgc     5220

agatgtttta gaaggaaaaa agttccttcc taaaataatt tctctacaat tggaagattg     5280

gaagattcag ctagttagga gcccaccttt tttcctaatc tgtgtgtgcc ctgtaacctg     5340

actggttaac agcagtcctt tgtaaacagt gttttaaact ctcctagtca atatccaccc     5400

catccaattt atcaaggaag aaatggttca gaaaatattt tcagcctaca gttatgttca     5460

gtcacacaca catacaaaat gttccttttg cttttaaagt aatttttgac tcccagatca     5520

gtcagagccc ctacagcatt gttaagaaag tatttgattt ttgtctcaat gaaaataaaa     5580

ctatattcat ttccactcta aaaaaaaaaa aaaaaa                               5616


<210>  12
<211>  2462
<212>  DNA
<213>  Homo sapiens

<400>  12
ggcacgaggg tgcggccctg ctcggcctcc cccagcagtg agatggtcac cttggaggag       60

ttcctggagg agagcaaccg cagctccccc acccatgaca ctcccagttg ccgggatgac      120

ctgctgagtg actacttccg aaaggccagc gatcccccag ccatcggagg ccaaccagga      180

ccacctgcca agaaagaagg ggccaagatg cccaccaact ttgtggcccc caccgtcaaa      240

atggccgccc ccacctcgga ggggaggccg ctgaagcccg ggcagtacgt aaagccaaac      300

ttcagactga ctgaggccga ggccccaccc agcgtggccc cgagacaggc ccagcctccc      360

cagagcctgt ctctgggcag accccggcag gctccggtgc ccccagcttc ccatgcacct      420

gccagccgca gtgcctcctt gagccgggcc ttcagcctgg cctcagctga ccttctccgg      480

gccagcgggc cagaggcctg caaacaggag tcccctcaga agctgggggc tcctgaggcc      540

ttagggggca gagagacagg cagccacacc ctgcaaagcc ccgcaccccc cagctcccat      600

agcctggccc gggagcggac cccacttgtg ggaaaggctg gcagctcctg tcagggccca      660

ggtccccgca gccggccgct ggacacgagg cgcttctccc tggctccccc aaaggaggag      720

aggctggccc ccctgcatca gtctgccaca gcccccgcca ttgccactgc aggtgctggt      780

gctgctgctg ctggcagtgg cagcaactcc cagctcctgc acttctcacc tgctgcagcc      840

ccggctgcca ggaccaagcc caaggcgccc ccacgctcag gggaggtggc caccatcacc      900

cctgtccggg cagggctcag cctctcagag ggagacgggg tcccggggca gggctgcagt      960

gaggggcttc cggccaagag cccaggtcgg tctcccgatt tggctcccca ccccggccgg     1020

gccctggagg actgcagtcg agggagcgtc tcaaagagca gtccggcctc cccggagccc     1080

ggcggggatc cgcagaccgt gtggtatgag tacggctgtg tgtgactgtc tcgtggttga     1140

gctcgcaaac ctgaaaacta ctgacgcgcc ttccgactct cacggccttt tctcttgctt     1200

gcctgcggtg ccaggagagg gtttggaatg aggaaagggg ttcccacgca tttctgctgt     1260

ttgttctgtg aatggaaaca ctgtgccaag ccccaagagg attacgcttc caggtgtgta     1320

acgtgttttc tgtgtctgcc gcttccagca gctgatatct ttggaacaaa taatccacgt     1380

cagcatgggg accaattcgg atgcaatgac aaactgactt cccccaaagc agacactact     1440

ccagtatgtc ccagtagaac actcatttgc aatgtgttga gctccgttaa gcacacacac     1500

actcacacaa caggctcacg aggctcaggc ctggcgggtc agaaagccca ctccctctcc     1560

caaggccact ggatcccagg agaagcccag actggcgata ctacaaaggt ctccagggcc     1620

tggcagaccc cagagtcagg cctgctgtta aaaagtgaga gtgctgctgt tccattcctg     1680

gggtcccaag cacttccctt taccccagga cccagggcag cctgcagggc agctggcggt     1740

ggccttggcc atttgccccc agcctccagc tggctcctga gctctgcacc agggggtttg     1800

gggaccacac aggcacctgc cttcctagat ttccctggct cacttttctg caaacactgg     1860

atctgccagg cctggggatt ggggggcagg aaagaggccc ccatccagcc ccctccaggc     1920

cagtgtgcac agtgcaccga ggggtcatcc gcacagagcg aggtgcaagc tcgatgtgta     1980

acctggctgc ggcacccgac atccccggtc tcggggtgtt gatttatttc tgaataactt     2040

tttgggtata gaaaccaatt ttttttaata tatgacatgt atatgtacac actcatgtga     2100

aatatgtata ctttgggggg atctatttat gttccagtgg gagtcactct cttctgtcgg     2160

gaatcttatc tgctgctttg tgtctttggt cagattcctg acaatttagt ttcctgttgt     2220

aaaggtgctt ttcctggggt gaactaaacc tattgatttt ttttttttaa gatttttttt     2280

tccttttgat ttaatatact gagaaagaaa tgggagactt ttgaatgtta acaagatcca     2340

ttttaggagt gtttggggtt gtgtattaaa tagccattca ttctggaact caaggacagg     2400

actgtaataa aatggaatgg aaccgaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa     2460

aa                                                                    2462


<210>  13
<211>  2592
<212>  DNA
<213>  Homo sapiens

<400>  13
gagccggctt ggggcccagc atacacaggc ccccaggacc cctggggaga gggccccgct       60

gggctggccc tgcagggacc atggaatcca gagctgaagg gggctcccct gctgtgtttg      120

attggttctt cgaagcggcc tgccctgcct ccctgcagga ggatcccccc atcctgcggc      180

agttccctcc agacttcagg gaccaggaag ctatgcagat ggtgcctaaa ttctgcttcc      240

cttttgatgt ggaaagggag ccccccagcc ccgccgtgca gcatttcacc ttcgccctca      300

cagaccttgc cggcaaccgc agatttggtt tctgccgcct gcgggcgggt acccagagct      360

gtctctgcat cctcagccac ctgccttggt tcgaggtgtt ttacaagcta ttgaacacag      420

tgggagacct cctagcccag gaccaagtca ccgaggcaga ggaacttctt caaaatctgt      480

ttcagcagtc cctgtctggg ccccaggcct cagtggggct tgagctgggc agcggagtga      540

cggtctccag cgggcagggt atcccccccc ctacccgggg gaatagcaag ccgctttcct      600

gcttcgtggc cccggactcc ggccgcctgc catccatccc tgagaacagg aacctaacgg      660

agctggtggt ggccgtgact gacgagaaca tcgtggggct gttcgcggcg ctcctggccg      720

agagaagagt cctgctcacc gccagcaaac tcagcaccct gacctcgtgc gtccacgcgt      780

cctgcgcgct cctgtacccc atgcgctggg agcacgtgct gatccccacg ctgcccccac      840

acctgctgga ctactgctgc gcgcccatgc cctacctcat tggagtgcac gccagtctcg      900

ccgagagagt acgagaaaaa gccctggagg acgtcgtggt gctgaacgtg gacgccaata      960

ccttggagac gacctttaac gacgtgcagg cgctgcctcc agacgtggtg tccctgctga     1020

ggctccggct caggaaggtc gccctggccc ccggggaagg ggtgtcccgt ctcttcctca     1080

aagcccaggc cctgctcttc ggggggtacc gcgacgcact cgtctgcagc ccgggccagc     1140

cagtgacctt cagtgaggaa gtcttcttgg cccagaagcc tggggcacct ctgcaggcct     1200

tccaccggcg ggctgtgcac ctgcagctgt tcaaacagtt catcgaagcc cggctggaga     1260

agctcaacaa gggggagggc ttctcagatc aattcgagca ggagatcact ggctgcgggg     1320

cctcctcagg ggcccttcga tcctatcagc tctgggccga caatctaaag aaaggtggtg     1380

gcgccctcct gcactcagtc aaggccaaga cccaaccagc cgtcaagaac atgtaccgct     1440

cggccaagag tggcttgaag ggggtgcaga gccttctaat gtataaggat ggggactctg     1500

tcctgcagag ggggggctct ctgagggccc cagccctccc cagccgctca gaccgcctgc     1560

agcaacgcct cccaatcact cagcactttg gaaagaaccg gccccttcgc cccagcagga     1620

gacgccagct ggaagaggga acttccgagc ccccaggggc ggggacaccc ccactgagcc     1680

ctgaggatga ggggtgcccg tgggcagaag aagctctgga cagcagcttc ttggggtctg     1740

gagaagaact ggatttgttg agcgagattc tggacagtct tagcatggga gccaagagcg     1800

caggcagcct gagaccgagc cagagtttag actgctgtca cagaggagac ctggacagct     1860

gcttcagcct gcccaacata ccaagatggc aaccagacga taagaaacta ccagagccgg     1920

agccccagcc cctttccctg ccatccctgc aaaatgcctc gtctttggat gccaccagct     1980

cttcaaagga ctccaggtcc cagctgatac cctcagagtc cgaccaagaa gtcacgtctc     2040

catcccagtc ctcaacagct tctgcagacc caagcatctg gggggacccc aaaccctctc     2100

ctctcacaga gcccctaatt cttcatctca ccccttccca caaggcagct gaagattcta     2160

cagcccagga aaaccccact ccctggctct ccactgcacc cactgagccc agccctccag     2220

aaagccccca aattctggcc cccacaaagc ccaactttga tatagcctgg acgtcccagc     2280

cccttgatcc ttcctcagac cccagttctc tggaggaccc cagagcccgg cctcccaaag     2340

ccctgctggc agagcgcgct cacctccagc cacgggagga accaggagcc ctgaattccc     2400

ctgctacacc caccagcaac tgtcaaaagt cccagcccag cagccggccc agagtcgctg     2460

atcttaagaa gtgctttgag ggttaagaat caggggtcca agagagaccc cagtccctca     2520

ataaagccac aagagcccaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa     2580

aaaaaaaaaa aa                                                         2592


<210>  14
<211>  5078
<212>  DNA
<213>  Homo sapiens

<400>  14
gcagtcagca gaggagagcg ccaggacgct acagcagctg aagaggcagt ggcgcccgcg       60

gccgcagcgt cggggctgga gcgatggcgg cgaccgcggt ggcggcggct gtggcgggaa      120

ccgagtcggc ccagggtccc ccgggcccgg cagcgtcgct ggagctgtgg ctgaacaaag      180

ccacagaccc aagcatgtcg gaacaggatt ggtcagctat ccagaatttc tgtgagcagg      240

tgaacactga ccccaatggc cccacacatg cgccctggct actggcccac aagatccagt      300

ctccgcaaga gaaggaagct ctttatgcct taacggtgct ggagatgtgc atgaaccact      360

gtggggagaa gttccacagc gaggtggcca aatttcgttt cctgaacgaa ctgatcaaag      420

tgttgtcccc aaagtacctg gggtcctggg ccacaggaaa agttaaagga agagtcattg      480

aaatactctt cagttggaca gtctggtttc cggaagacat caagattcga gacgcttatc      540

agatgctgaa gaaacaagga attataaaac aagaccctaa actaccagtg gataaaatct      600

tacccccacc atctccctgg cccaagagct ccatctttga tgctgatgaa gaaaagtcca      660

agctctttct cagtgccagt gagcccggcc ctatccattt tccatccacc atgaactccc      720

caaaccgtta ttccttggac atcagtatct agagggacaa gaagaagaag gtggccaaga      780

cccagggata actgtggtgc ctcttctgac aaggcttcta aagagcaacc accccgagga      840

ccttcaggct gcaaaccggt taatcaagaa tttggtcaag gaggaacaag aaaaatcgga      900

gaaggtgtcc aagagggtca gtgcggtgga ggaagtgcga agccatgtga aggtgctgca      960

ggagatgctg agcatgtacc gcaggccagg gcaggccccg cccgaccagg aggccctgca     1020

ggtcgtgtat gagaggtgtg aaaagctgcg gcccacgctg ttccggttgg cgagtgacac     1080

cactgatgac gatgatgcac tcgcggaaat tctccaggca aatgacctcc tcacccaagg     1140

agttctgctg tacaaacagg tgatggaggg ccgggtcacc tttggaaaca gagtgaccag     1200

ctcattggga gacatccctg tctccagagt ctttcagaat ccagcaggct gcatgaagac     1260

ctgccccctg attgacttgg aggtggacaa tggacctgcg cagatgggga ctgtggtgcc     1320

atctttgctt catcaggacc tggcagcctt gggaatcagt gatgctcctg ttacaggcat     1380

ggtttctggt cagaattgct gtgaggaaaa gaggaatccc tcctccagca cgctgccagg     1440

cggtggtgtt cagaaccctt ctgcagacag gaatttgctg gacctcctct caccacagcc     1500

agctccgtgc cctctgaatt atgtttcgca gaaaagtgtc cccaaggaag tgccaccagg     1560

tactaagtcc tctccaggtt ggtcctggga tatcatgttt caagtggctg tgccaaagtc     1620

aatgagagtg aagctgcagc cggcatccag ctccaagctt cctgcattca gtcctttgat     1680

gcctccagct gtgatatctc agatgctgct gcttgacaat ccacacaaag aacctatccg     1740

cttacggtac aagctgacat tcaaccaagg tggacagcct ttcagcgaag taggagaagt     1800

gaaagacttc ccagacctgg ctgtcttggg cgcagcctaa cttttcacaa gatggaccct     1860

tcatttcaag cttaggctgg cgttactttt gctgtctagt caggactaat cacggtgttt     1920

cagtgcggag tgccaagagt cctatcctga cgtcaggctc tgggtgtcaa cctctgactt     1980

attctgcaga tgctctgtgt gtgtgtgtgt gtgtgtgtgt gtgtgtgtgt gtgtgtgtgt     2040

gtgtgtgtgt gtgtgtgtgt gttcggggag agggtggtag cacagggctt gggatatcgg     2100

cagtgtggga aatgcgaagc atttctcatc atcatcatct ctgctacagt catgtttctg     2160

catgtcagcg agcgacactg tccctgcctc aggttggagg ttttatcagc caaagtgttt     2220

ttttcatgta tcgttcgttc cattcatcca ctctgtgcct tgtcagcctt tgaaaggctt     2280

ggttgctccc aggctgctgt tctcagggac cttaaaaggg acctggttag tcttggggca     2340

gagagtatct acttgggcac tctcttccaa gaaagacctt gtctccattt tcattagaca     2400

atgcttcttg tgtgtgttct ggaagatctt ctaaatggaa tgcttgttgc actgttccca     2460

ggcgagtggc tgccatgaga cctgaggacc acacttgggg gaccaatcat gtccttcacc     2520

actgtgcctt agaatcgccc ctggacagag ttcctgggca gaggggaaag cagctcccag     2580

gccttactca ggcctcaggt ccatgggttg ggcagccagt ctgggccctt ctcaggatcc     2640

tcatctccat cctcatcctc ttccttcaca gcatttactt ggagctcttt gtgacacacc     2700

atgtcagtca tgatgaatcg gccaacagcc agcccttgcc agctgacgtc acagtctaag     2760

atgggaaact gtggtacaga tagacatgaa gagagcttag cagtgattga ggtggtgact     2820

aaatatacag tcattgaata aataccatgt agcaagtgta ctttgtggag tgttgagtaa     2880

gtggaaaatg gaaagccagt tgcatttaga gatgataggc ctaaagggaa ctgtcttctg     2940

tcgagaagta aaggaaactt catgaaggat gtagaagctt agctgcctca gagaagagag     3000

aacctgaaga tctgaggcaa gctggacagg agaggtggat atttgttgat ggaagaattc     3060

aagtttataa tcaattccca cttagcacct actgtgtgct aggaacttga atgtgtatgt     3120

ttgacaagtc ctgcttggcc tgatgggtgg gagaaggaac ctgagcctgg ctgagatggc     3180

taggcggagg gctttgaagt ccaagcagct gaactggctg ggtgggtttc tacctttgaa     3240

actgcaagac ttgtttggag ctcttaatta caatatctga tatttttaca gtctgatctt     3300

ttgacttcta catatagtgg aaatctgcca atactaattg gtggagatgg gaactgtaaa     3360

agatcaagta tgctaatttt aagcaaatgt aaaaactcat aaaacaggta aacagtgggg     3420

tgatttcatt tgccataatt cacataagac gaattttaat ctaaaagtac tttcttgctt     3480

gtattctgtg tggctttttt ttgttttttg aggccatatc tcactctgtc actcaggctg     3540

gagtgcggtg gtataatctc agcctctcga gtagctggga ctacaggcgt gagccagcac     3600

gcccagctaa tttttgtatt tttagtagag acaggatttc accatgttgg ccaggctggt     3660

ctcgaactcc tgacctcagg tgatccgcct gccttggcct cccagagtgc tgggattaca     3720

ggcgtgagcc accgcacccg gcctctgtgt agcttttata ggctctgtta ctgttgcgta     3780

gtcttgaaga ggtacccatc ataatgacag catctccctc tgaagggttt tggtcaaaat     3840

gggtgaatga gacttataca taaagacagg ctttctcccc tatagttagg aggtgaactc     3900

acacatgtgt acctgaacat tcttgctttt gaggagacag actcccagtg gtactactat     3960

gcttaggtgt tggacaggat aggggtagga ggagaggagg caggctgctg tcctgaaagt     4020

ggctgtggtt tatggcatca ctcccttcta atcagcaagt ccagtggcca cttagagccc     4080

agctcctacc tcttcattca cttaacaagt agttattggc tgtgcacagt ggctcacgcc     4140

tgtagtccca gcattttggg aggctgagtg ggatgaccgc ttgagcccag gatttcaagt     4200

ccagcctggg ctacatagtg agaccgtgtc tctgtttttt taaaagctag ttgttgacca     4260

gctaccctga gccaggcacc accctgaagg agcttctttt cctctgggga gaagcaaatt     4320

catgatgtgt gtgctggaga tctggcactc atggccagtg ctttccagta tcttgaactc     4380

ttcgggggtc ctgttgaccc atttcgtgac ctacctccgt gactgctctt tttcctctgt     4440

ctcttaagtg tgatggtttt ccagagtcca atcctcagga ctttcccgtc cacacacagg     4500

cctggtagtc aggtggctct aaaccattag gtgggttgta gacctctctc aagctgccac     4560

ctccttgctg tcgccagatc gtatttcagt ctgtcagggg ttatctgtat ctggaggttc     4620

cactgttgct tcagtctcag ttacttagaa tggaacccag agtcctgccc ctttccacct     4680

acatgctctt acttgaaagc acctgagact tattgggtcc ctgattcctg cttcgtctgt     4740

atccgcagag tagttgcatg tcatttggcc tgttttctaa ataatcccac atcatgtcct     4800

ccctgcactt acattgccac tgctctgatt tgggcttttt tttttttggg acaatgcctc     4860

tgtcccaatt ctgagtaaca gctctggttc ttgccactac cagagttctc tagcaaatct     4920

gagcatctga cagggtgaaa aattctgaat ggcttcctga tgcctgactt tatgggatca     4980

aattcaagtt gcacgctggc actcagtgcc cttctggtat catctgccaa gaccagggcc     5040

tgcttcacca cagccacaat aaagtccttt caagccct                             5078


<210>  15
<211>  1750
<212>  DNA
<213>  Homo sapiens

<400>  15
aaagagcacc tttctccctc ccctgcccac ctcagtccag aatctcgccc acccgccaga       60

agtcgtgttg acagatttcc agaccctgga tggaagccag tacaacccgg tcaaacagca      120

gctagtgcgt tacgccacca gctgttacag ctgttgtccg cgactggcct cggtgctgct      180

atactccgat tatgggatag gagaagtgcc cgtggagccc ctggatgtcc ccttaccctc      240

cacgatcagg ccagcttccc ccgtggccgg gtctccaaag cagccggtgc gtggctacta      300

ccgtggcgct gtcggtggca cgtttgaccg cctgcacaac gcccacaagg tgttgctcag      360

tgtcgcgtgc atcctggccc aggagcagct tgtggtggga gtagcagaca aagatctgtt      420

gaagagcaag ttgctccctg agctgctcca accttataca gaacgtgtgg aacatctgag      480

tgaattcctg gtggacatca agccctcctt gacttttgat gtcatccccc tgctggaccc      540

ctatgggccc gctggctctg acccctccct ggagttcctg gtggtcagcg aggagaccta      600

tcgtgggggg atggccatca accgcttccg ccttgagaat gacctggagg aacttgcttt      660

gtaccagatc cagctgctga aggacctcag acatacagag aatgaagagg acaaagtcag      720

ctcctccagc ttccgccagc gaatgttggg gaacctgctt cggcctccat atgaaaggcc      780

agagctcccc acatgtctct atgtaattgg gctgactggc atcagtggct ctgggaagag      840

ctcaatagct cagcgactga agggcctggg ggcgtttgtc attgacagtg accacctggg      900

tcatcgggcc tatgccccag gtggccctgc ctaccagcct gtggtggagg cctttggaac      960

agatattctc cataaagatg gcatcatcaa caggaaggtc ctaggcagcc gggtgtttgg     1020

gaataagaag cagctgaaga tactcacgga cattatgtgg ccaattatcg caaagctggc     1080

ccgagaggag atggatcggg ctgtggctga gggaaagcgt gtgtgtgtga ttgatgccgc     1140

tgtgttgctt gaagccggct ggcagaacct ggtccatgag gtgtggactg ctgtcatccc     1200

agagactgag gctgtaagac gcattgtgga gagggatggc ctcagtgaag ccgcggctca     1260

aagccggctg cagagccaga tgagcgggca gcagcttgtg gaacagagcc acgtggtgct     1320

cagcaccttg tgggagccgc atatcaccca acgccaggtg gagaaagcct gggccctctt     1380

gcagaagcgc attcccaaga ctcatcaggc cctcgactga aaagttctca gtggggccag     1440

actggctcct ggagctgaca agcgaccccg tggtgaggag aaatgggggc cttgatgctc     1500

accctggttc aggcccagag gtccaagcta tactgtgcag gacatggcca ggcctggtgg     1560

acacaggaag cctacccaac acgctggtat ttggccaaca ctgaggatgt ggttcatggg     1620

ggagcagtcc cctccccact cttgcccatg ggtgactctt acccacagct gactagggcc     1680

agcgcaaata ctggaacctg taacagaatt aaaggtgaat gttctgagat gttaaaaaaa     1740

aaaaaaaaaa                                                            1750


<210>  16
<211>  3429
<212>  DNA
<213>  Homo sapiens

<400>  16
ctgaggcggc gacgagtggt aggagtcttc tttcccctcc ttcccctttc ccttcccttc       60

ccgggagagg ctgggacccg gcaccagggc agtactgtgg ccgctgcggc ctcagctccg      120

actgggtcag gttgcggaga ctccaggccg cttccagggc gagtactcct gattgtgaca      180

tcacattcat cccctgggcg atggagcttg tcactgggaa ggaatactca gtcggagaat      240

agccaacaag atgggttact gggagaatct cttcagtggc actgagtgga ggcatcaggg      300

ggttggagcc ttgtgaacag ggaacctgcc ccccaacact tggaaggacc tgggtttcag      360

tgatgagaca tggggtatga tgtaacccgt ttccaggggg atgttgacga agatcttatc      420

tgccctattt gcagtggagt cttggaggag ccagtacaga ccagcttttg atacagccat      480

gcactctgca ttttgatgtg aaagctgcca ccttcaatag gtcatttctc tgccagcctt      540

gccagaccag agtcagttgt atcatcctgg ggcaagtatg aggagaagct cacgattacc      600

aggcacctca ttgtgaacat gctttctgca acgcctgcat cacccagtgg ttctctcagc      660

aacagacatg tccagtggac cgtagtgttg tgacggtcgc ccatctgcgc ccagtacctc      720

ggatcatgcg gaacatgttg tcaaagctgc agattgcctg tgacaacgct gtgttcggct      780

gtagtgccgt tgtccggctt gacaacctca tgtctcacct cagcgactgt gagcacaacc      840

cgaagcggcc tgtgacctgt gaacagggct gtggcctgga gatgcccaaa gatgagctgc      900

ccaaccataa ctgcattaag cacctgcgct cagtggtaca gcagcagcag acacgcatcg      960

cagagctgga gaagacgtca gctgaacaca aacaccagct ggcggagcag aagcgagaca     1020

tccagctgct aaaggcatac atgcgtgcaa tccgcagtgt caaccccaac cttcagaacc     1080

tggaggagac aattgaatac aacgagatcc tagagtgggt gaactccctt cagccagcaa     1140

gagtgacccg ctggggaggg atgatctcga ctcctgatgc tgtgctccag gctgtaatca     1200

agcgctccct ggtggagagt ggctgtcctg cttctattgt caacgagctg attgaaaatg     1260

cccacgagcg tagctggccc cagggtctgg ccacactaga gactagacag atgaaccgac     1320

gctactatga gaactacgtg gccaagcgca tccctggcaa gcaggctgtt gtcgtgatgg     1380

cctgtgagaa ccagcacatg ggggatgaca tggtgcaaga gccaggcctt gtcatgatat     1440

ttgcgcatgg cgtggaagag atataagaga actcgactgg ctatcaggaa gagatggaaa     1500

tcagaaaatc ccatcactcc agcagctggg acctgagtcc tacccaccat tcttaatact     1560

gtggcttata cctgagccac acatctccct gcccttctgg cactgaaggg ccttggggta     1620

gtttgctcag cctttcaggt gggaaaccca gatttcctcc ctttgccata ttcccctaaa     1680

atgtctataa attatcagtc tgggtgggaa agcccccacc tccatccatt ttcctgctta     1740

gggtccctgg ttccagttat tttcagaaag cacaaagaga ttcaatttcc ctggaggatc     1800

aggacagagg aaggaatctc taatcgtccc tctcctccaa aaccagggaa tcagagcagt     1860

caggcctgtt gactctaagc agcagacatc ctgaagaaat ggtaagggtg gagccaaatc     1920

tctagaaata agtagtgagg ccgttaattg gccatcactg atggccctta gggaaagact     1980

ggacctctgt gccaagcagt atccctgttc agcccacctt aaaggtgtag gcacccactg     2040

ggtctaccag tatgcaggtt gggatactga aaatttccag atgagctctt ctttcctaca     2100

agttttcata attagggaat gccagggttt agggtagggg ttaatctgtt gggggttgat     2160

gtgtttagca agaagctact cctagctttt gctaaaatat ggttggcact gcctcttgtg     2220

gcacaggcca taattgttcc atagacccct ctctagccct gtgactgtag ttagttactt     2280

tgataatttt ctttggccat tgtttgttta tatttcacaa actccaccta ctgccccccc     2340

ccctcttttt tttaagaatg gcctgatcat ggctatctca gccacattgt tggcaattta     2400

atttatttac ttcctttttt tttttttaag aaaggaaaaa agaaaaaaaa atcaaacttg     2460

aaacttttct tttgatgttc ctattgtggg ggttctggat agggtgggac agggatgggg     2520

gtgtgtttta tattttttcc ttttcagcac aacctttggc tttaatatag gaagagccaa     2580

gggagtcctc ggctgaactt acgatatctg ccccaaacct ctgtaacccc aactgaaatg     2640

aggagcttcc tctcttcctg tgaaggatat gacagtccag catcgatgcc tgtgccctct     2700

ggaaaaattt cctcctagcc cttccagggc cttatcataa aactctggat ttagagtatt     2760

cattttgaag gcaactcccc cttccccaag tttccttgga gctgtatagc tgggttctaa     2820

gcttcaccat gcaaatcaga aattttatct ctaagtacag gctgtgccgt gtctcaccca     2880

cacccccctg gggacttcag ttccatttca ggttacctgg ggtatacctt gatccctaga     2940

gtgactggca gagtaagaga aggggagaga taataggtgt gattatttta atatggaggt     3000

gggagtgtgg ttggagatag aaaggctcct ccccaccatg taatggcttc ctctcagaat     3060

tttattccag gctagcttgc tgcaggtctg ggtagttgga tcatggctcc actgggattg     3120

gggtggaaag cttgagggga gtagggttcc agctctggga cattgtgctc aggaatttga     3180

aaacgctgct atacttactc tggttactac atttcttcca ctcccctttc ccctacctgc     3240

cttaaccaag gctcatactg tcctgtcctt accctcagat ggagccagga agctcagtga     3300

aaggcttccc taccctttgc actagtgtct ctgcaggttg ctggttgtgt tgtatgtgct     3360

gttccatggt gttgactgca ctaataataa accttttact caactctcta aaaaaaaaaa     3420

aaaaaaaaa                                                             3429


<210>  17
<211>  886
<212>  DNA
<213>  Homo sapiens

<400>  17
gtcggttccg ggcgttacca tcgtccgtgc gcaccgcccg gcgtccaggt gagtctccca       60

tctgcagaga cgcggacgcg ccggcccgca gttggcctgc ggagcgcggt ggacggtttg      120

gcgcccacca ggcgatcaat actttggatt tttaatttct agatttggca attcttcgct      180

gaagtcatca tgagcttttt ccaactcctg atgaaaagga aggaactcat tcccttggtg      240

gtgttcatga ctgtggcggc gggtggagcc tcatctttcg ctgtgtattc tctttggaaa      300

accgatgtga tccttgatcg aaaaaaaaat ccagaacctt gggaaactgt ggaccctact      360

gtacctcaaa agcttataac aatcaaccaa caatggaaac ccattgaaga gttgcaaaat      420

gtccaaaggg tgaccaaatg acgagccctc gcctctttct tctgaagagt actctataaa      480

tctagtggaa acatttctgc acaaactaga ttctggacac cagtgtgcgg aaatgcttct      540

gctacatttt tagggtttgt ctacattttt tgggctctgg ataaggaatt aaaggagtgc      600

agcaataact gcactgtcta aaagtttgtg cttattttct tgtaaatttg aatattgcat      660

attgaaattt ttgtttatga tctatgaatg tttttcttaa aatttacaaa gctttgtaaa      720

ttagattttc tttaataaaa tgccatttgt gcaagatttc tcaaagatta ggtatatatt      780

taaatggaag agaaaatatt tttatgggag aaaaatacat ttgaaccatg aaatttcatc      840

ttttaaataa catccagtac agatatctgt gtaaaaaaaa aaaaaa                     886


<210>  18
<211>  5616
<212>  DNA
<213>  Homo sapiens

<400>  18
ccccggcgca gcgcggccgc agcagcctcc gccccccgca cggtgtgagc gcccgacgcg       60

gccgaggcgg ccggagtccc gagctagccc cggcggccgc cgccgcccag accggacgac      120

aggccacctc gtcggcgtcc gcccgagtcc ccgcctcgcc gccaacgcca caaccaccgc      180

gcacggcccc ctgactccgt ccagtattga tcgggagagc cggagcgagc tcttcgggga      240

gcagcgatgc gaccctccgg gacggccggg gcagcgctcc tggcgctgct ggctgcgctc      300

tgcccggcga gtcgggctct ggaggaaaag aaagtttgcc aaggcacgag taacaagctc      360

acgcagttgg gcacttttga agatcatttt ctcagcctcc agaggatgtt caataactgt      420

gaggtggtcc ttgggaattt ggaaattacc tatgtgcaga ggaattatga tctttccttc      480

ttaaagacca tccaggaggt ggctggttat gtcctcattg ccctcaacac agtggagcga      540

attcctttgg aaaacctgca gatcatcaga ggaaatatgt actacgaaaa ttcctatgcc      600

ttagcagtct tatctaacta tgatgcaaat aaaaccggac tgaaggagct gcccatgaga      660

aatttacagg aaatcctgca tggcgccgtg cggttcagca acaaccctgc cctgtgcaac      720

gtggagagca tccagtggcg ggacatagtc agcagtgact ttctcagcaa catgtcgatg      780

gacttccaga accacctggg cagctgccaa aagtgtgatc caagctgtcc caatgggagc      840

tgctggggtg caggagagga gaactgccag aaactgacca aaatcatctg tgcccagcag      900

tgctccgggc gctgccgtgg caagtccccc agtgactgct gccacaacca gtgtgctgca      960

ggctgcacag gcccccggga gagcgactgc ctggtctgcc gcaaattccg agacgaagcc     1020

acgtgcaagg acacctgccc cccactcatg ctctacaacc ccaccacgta ccagatggat     1080

gtgaaccccg agggcaaata cagctttggt gccacctgcg tgaagaagtg tccccgtaat     1140

tatgtggtga cagatcacgg ctcgtgcgtc cgagcctgtg gggccgacag ctatgagatg     1200

gaggaagacg gcgtccgcaa gtgtaagaag tgcgaagggc cttgccgcaa agtgtgtaac     1260

ggaataggta ttggtgaatt taaagactca ctctccataa atgctacgaa tattaaacac     1320

ttcaaaaact gcacctccat cagtggcgat ctccacatcc tgccggtggc atttaggggt     1380

gactccttca cacatactcc tcctctggat ccacaggaac tggatattct gaaaaccgta     1440

aaggaaatca cagggttttt gctgattcag gcttggcctg aaaacaggac ggacctccat     1500

gcctttgaga acctagaaat catacgcggc aggaccaagc aacatggtca gttttctctt     1560

gcagtcgtca gcctgaacat aacatccttg ggattacgct ccctcaagga gataagtgat     1620

ggagatgtga taatttcagg aaacaaaaat ttgtgctatg caaatacaat aaactggaaa     1680

aaactgtttg ggacctccgg tcagaaaacc aaaattataa gcaacagagg tgaaaacagc     1740

tgcaaggcca caggccaggt ctgccatgcc ttgtgctccc ccgagggctg ctggggcccg     1800

gagcccaggg actgcgtctc ttgccggaat gtcagccgag gcagggaatg cgtggacaag     1860

tgcaaccttc tggagggtga gccaagggag tttgtggaga actctgagtg catacagtgc     1920

cacccagagt gcctgcctca ggccatgaac atcacctgca caggacgggg accagacaac     1980

tgtatccagt gtgcccacta cattgacggc ccccactgcg tcaagacctg cccggcagga     2040

gtcatgggag aaaacaacac cctggtctgg aagtacgcag acgccggcca tgtgtgccac     2100

ctgtgccatc caaactgcac ctacggatgc actgggccag gtcttgaagg ctgtccaacg     2160

aatgggccta agatcccgtc catcgccact gggatggtgg gggccctcct cttgctgctg     2220

gtggtggccc tggggatcgg cctcttcatg cgaaggcgcc acatcgttcg gaagcgcacg     2280

ctgcggaggc tgctgcagga gagggagctt gtggagcctc ttacacccag tggagaagct     2340

cccaaccaag ctctcttgag gatcttgaag gaaactgaat tcaaaaagat caaagtgctg     2400

ggctccggtg cgttcggcac ggtgtataag ggactctgga tcccagaagg tgagaaagtt     2460

aaaattcccg tcgctatcaa ggaattaaga gaagcaacat ctccgaaagc caacaaggaa     2520

atcctcgatg aagcctacgt gatggccagc gtggacaacc cccacgtgtg ccgcctgctg     2580

ggcatctgcc tcacctccac cgtgcagctc atcacgcagc tcatgccctt cggctgcctc     2640

ctggactatg tccgggaaca caaagacaat attggctccc agtacctgct caactggtgt     2700

gtgcagatcg caaagggcat gaactacttg gaggaccgtc gcttggtgca ccgcgacctg     2760

gcagccagga acgtactggt gaaaacaccg cagcatgtca agatcacaga ttttgggctg     2820

gccaaactgc tgggtgcgga agagaaagaa taccatgcag aaggaggcaa agtgcctatc     2880

aagtggatgg cattggaatc aattttacac agaatctata cccaccagag tgatgtctgg     2940

agctacgggg tgaccgtttg ggagttgatg acctttggat ccaagccata tgacggaatc     3000

cctgccagcg agatctcctc catcctggag aaaggagaac gcctccctca gccacccata     3060

tgtaccatcg atgtctacat gatcatggtc aagtgctgga tgatagacgc agatagtcgc     3120

ccaaagttcc gtgagttgat catcgaattc tccaaaatgg cccgagaccc ccagcgctac     3180

cttgtcattc agggggatga aagaatgcat ttgccaagtc ctacagactc caacttctac     3240

cgtgccctga tggatgaaga agacatggac gacgtggtgg atgccgacga gtacctcatc     3300

ccacagcagg gcttcttcag cagcccctcc acgtcacgga ctcccctcct gagctctctg     3360

agtgcaacca gcaacaattc caccgtggct tgcattgata gaaatgggct gcaaagctgt     3420

cccatcaagg aagacagctt cttgcagcga tacagctcag accccacagg cgccttgact     3480

gaggacagca tagacgacac cttcctccca gtgcctgaat acataaacca gtccgttccc     3540

aaaaggcccg ctggctctgt gcagaatcct gtctatcaca atcagcctct gaaccccgcg     3600

cccagcagag acccacacta ccaggacccc cacagcactg cagtgggcaa ccccgagtat     3660

ctcaacactg tccagcccac ctgtgtcaac agcacattcg acagccctgc ccactgggcc     3720

cagaaaggca gccaccaaat tagcctggac aaccctgact accagcagga cttctttccc     3780

aaggaagcca agccaaatgg catctttaag ggctccacag ctgaaaatgc agaataccta     3840

agggtcgcgc cacaaagcag tgaatttatt ggagcatgac cacggaggat agtatgagcc     3900

ctaaaaatcc agactctttc gatacccagg accaagccac agcaggtcct ccatcccaac     3960

agccatgccc gcattagctc ttagacccac agactggttt tgcaacgttt acaccgacta     4020

gccaggaagt acttccacct cgggcacatt ttgggaagtt gcattccttt gtcttcaaac     4080

tgtgaagcat ttacagaaac gcatccagca agaatattgt ccctttgagc agaaatttat     4140

ctttcaaaga ggtatatttg aaaaaaaaaa aaagtatatg tgaggatttt tattgattgg     4200

ggatcttgga gtttttcatt gtcgctattg atttttactt caatgggctc ttccaacaag     4260

gaagaagctt gctggtagca cttgctaccc tgagttcatc caggcccaac tgtgagcaag     4320

gagcacaagc cacaagtctt ccagaggatg cttgattcca gtggttctgc ttcaaggctt     4380

ccactgcaaa acactaaaga tccaagaagg ccttcatggc cccagcaggc cggatcggta     4440

ctgtatcaag tcatggcagg tacagtagga taagccactc tgtcccttcc tgggcaaaga     4500

agaaacggag gggatggaat tcttccttag acttactttt gtaaaaatgt ccccacggta     4560

cttactcccc actgatggac cagtggtttc cagtcatgag cgttagactg acttgtttgt     4620

cttccattcc attgttttga aactcagtat gctgcccctg tcttgctgtc atgaaatcag     4680

caagagagga tgacacatca aataataact cggattccag cccacattgg attcatcagc     4740

atttggacca atagcccaca gctgagaatg tggaatacct aaggatagca ccgcttttgt     4800

tctcgcaaaa acgtatctcc taatttgagg ctcagatgaa atgcatcagg tcctttgggg     4860

catagatcag aagactacaa aaatgaagct gctctgaaat ctcctttagc catcacccca     4920

accccccaaa attagtttgt gttacttatg gaagatagtt ttctcctttt acttcacttc     4980

aaaagctttt tactcaaaga gtatatgttc cctccaggtc agctgccccc aaaccccctc     5040

cttacgcttt gtcacacaaa aagtgtctct gccttgagtc atctattcaa gcacttacag     5100

ctctggccac aacagggcat tttacaggtg cgaatgacag tagcattatg agtagtgtgg     5160

aattcaggta gtaaatatga aactagggtt tgaaattgat aatgctttca caacatttgc     5220

agatgtttta gaaggaaaaa agttccttcc taaaataatt tctctacaat tggaagattg     5280

gaagattcag ctagttagga gcccaccttt tttcctaatc tgtgtgtgcc ctgtaacctg     5340

actggttaac agcagtcctt tgtaaacagt gttttaaact ctcctagtca atatccaccc     5400

catccaattt atcaaggaag aaatggttca gaaaatattt tcagcctaca gttatgttca     5460

gtcacacaca catacaaaat gttccttttg cttttaaagt aatttttgac tcccagatca     5520

gtcagagccc ctacagcatt gttaagaaag tatttgattt ttgtctcaat gaaaataaaa     5580

ctatattcat ttccactcta aaaaaaaaaa aaaaaa                               5616


<210>  19
<211>  2618
<212>  DNA
<213>  Homo sapiens

<400>  19
agatgcaacg caagcaacga cttcgtcaca ctaaaacgga ttttgtgagg gccaaaagta       60

taaattacga agcagaaatg attatcaaac aacttccagc ggtttgcacc taaagaaaca      120

caaggagaac ccactacaaa caaacaaacc cagtccaaac aacgcctcca gtaggaaaag      180

aggaaaactg cgataacacg accccccgag aagagacgag accaacacgc tgagactgtg      240

gggcgtcagc aaacctccaa gtgcacggcg gactgagttg tacttcgcag ctctctggac      300

attaattacc tcctgcacct tccatttggg ggagggtgag gaagaaggca ctcacctaca      360

ctgagcgaag aagtcctatc agcgtggaag agaagtttaa gaatgaacca ctgaatgttt      420

cgcttttatt tttaaattta ctttggcact taaaaaacct catttccaga tttctggaca      480

atctcggctg cagacatcta agcctaacct tttggtatcc tgagtttttt ccctctcctt      540

ctccttcctc acgcccaccc cgcttctctc gcacacggtc atctttacat atcaagagaa      600

agcaaaaagg ttccaagagg tacttttctt tttagaaaat caccttttct cccctaattc      660

ttctgcagaa gaaaagaggt ttcgaaagag ggaaaaggaa aaaacaagcc ggctacggta      720

tcagccggtc agcccaggtg gaaaacgaga gtgaaagtag ggcttaacgg ggagcgcacc      780

gcctctttcg aaagccgctg ggccaccacc agtgcgtgag ccttggatcc ctcaacgtat      840

tgcgagacgc cggtgtatag cccggacctg tgccccaaca tgatcgccgc tcaggccaag      900

ctggtttacc agctcaataa gtactacact gagcgctgtc aggcgcgcaa ggcggccatc      960

gccaaaacca tccgagaggt ctgtaaggtg gtctcggacg tgctcaagga agtggaggtg     1020

caggagcctc gcttcatcag ctccttgagc gagatcgatg cccgctacga ggggctcgag     1080

gtcatttcgc ccaccgaatt tgaggtggtg ctctacctaa accagatggg cgtcttcaac     1140

ttcgtggacg acggctcgct gcccggctgc gcagtgctca aactgagcga tgggcggaag     1200

cggagcatgt ctctctgggt cgagttcatc acggcgtcgg gctatctctc agcgcgtaag     1260

atccgctcgc gtttccagac gctggtggcc caggcggtgg acaagtgcag ctatcgggat     1320

gtggtcaaga tgatcgcgga caccagcgag gtcaagttgc gcatcaggga gcgctatgtg     1380

gtgcaaatca ctccggcgtt caagtgcacc gggatctggc ctcgcagcgc ggcacagtgg     1440

cctatgcccc acatcccttg gcccggcccc aatcgggtgg ccgaggtcaa ggccgaaggg     1500

ttcaacttgc tctcgaagga gtgctactcg ctgaccggca agcagagctc ggcagagagc     1560

gacgcctggg tgctacagtt cggggaggcg gagaaccgcc tgctgatggg cggctgccga     1620

aacaagtgcc tctcagtgct gaagactctg cgggaccgcc acctggagct acccggccag     1680

ccgctcaaca actaccacat gaagacgctg ctgctgtacg agtgcgagaa acacccacga     1740

gaaacggact gggacgagtc gtgcctgggc gaccggctca acggcatcct gctgcagctc     1800

atctcctgcc tgcagtgccg ccgctgccct cactactttc tgcccaacct cgacctcttt     1860

cagggcaagc cccattcggc cctggagagc gctgccaagc agacctggag gttggccagg     1920

gaaattctca ccaatcccaa aagcctggac aaactatagg gtgctgggga ctgcttgaaa     1980

agcgacacaa acgggcgtgc tctctcagac acacaactca gctataaaca gcagaaactc     2040

tggacacaaa cttttatgta agtcacctga aataggaatc cggcagaaga ccttcattaa     2100

ttaagaagca aacaaaaaga gagcaaccca accaaaacaa atcacattct tgcacaaaag     2160

tgatcgtttt cttccaaaca atgtgaattt aaaaggtcac acaaaagaag caatcgggct     2220

ccgccaccac aaaatgaaac ccaaggtaca ttttcaaatc aatgtatagt agttcccccc     2280

ccttttcctt ctttccccct atcctttttc tctccacccc atcccccccc catttcgttt     2340

tgcttttggt tgcctgaatg ttgtcaccaa gtgaaaaaat tatttaacta tatgtaaaat     2400

ttctctttta aaaaaaagtt ttactgatgt taaacgttct cagtgccaat gtcagactgt     2460

gctcctccct ctcctgaacc tctaccctca ccctgagctg tcttgttgaa aacagtaata     2520

aaaacattac tttacattgt aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa     2580

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaa                             2618


<210>  20
<211>  2998
<212>  DNA
<213>  Homo sapiens

<400>  20
gctgagaggc gcgtactgtg cttgcttttt gcagtacctg ctgcggccgc tttcggcatg       60

gaggaaattt atgcgaagtt tgtgtcccag aaaatcagca aaacccgctg gcgaccgctg      120

cctccgggaa gtttacagac cgcggagacg ttcgctacag gatcttggga caatgaggaa      180

aattatattt cactgtggtc tattggagat tttggaaact tggactctga tggagggttt      240

gaaggagacc atcagttatt gtgtgatatc agacaccatg gtgatgtaat ggatttacag      300

ttttttgacc aggaaagaat tgtcgctgct tcatcaacag gatgtgtaac agttttcctt      360

caccatccaa ataaccagac tctgtcagtc aaccagcagt ggactacagc tcactaccac      420

acaggccctg gcagtccttc ctatagcagt gcaccatgta caggtgttgt gtgcaacaac      480

ccagaaatcg ttacagttgg agaggatggt cgaataaatc tcttcagagc tgatcacaag      540

gaagctgtaa gaaccataga caatgcagat agtagtacac tccatgctgt aacctttctt      600

cgaactcctg agattcttac tgtaaattca attggacagt tgaaaatatg ggatttcaga      660

caacaaggaa atgagccttc tcagatattg tcactgactg gtgaccgagt gccactccac      720

tgtgttgata gacatcccaa ccaacagcat gttgtagcta ctggtggcca agatggaatg      780

ttgagtattt gggatgttag acaaggtact atgcctgtat ctctgctgaa ggctcatgaa      840

gctgaaatgt gggaagttca ctttcaccca tccaacccag aacatctttt tacctgctct      900

gaagatggat ccctctggca ctgggatgct tccacagatg tacctgaaaa gtcgtcactc      960

tttcaccaag gaggaagaag cagtactttt ttgtctcata gcattagtaa ccaagctaat     1020

gttcaccagt ctgtcattag ctcctggctc agcactgatc ctgcaaaaga ccgaattgaa     1080

atcacaagct tacttcccag taggtctctg tctgtgaaca ctttggatgt tttaggtcct     1140

tgtcttgttt gtggaaccga tgcagaagca atttatgtta ctagacatct tttttcgtag     1200

aagtactata attataagat ttcagataga acatgcaatt agccttttga aatccaactt     1260

ctgtgcaaaa ttttagtatc agaaaatacg agatttgcag gggaaacatc agtaaactac     1320

cattaatgtc aatgcccagt tttgactttt gttagcctga cactcccaaa cagttgtaga     1380

atccgataga tgactgatgg caaaagattg tgaacatgtg gaagaaaatc agtgggattc     1440

tggtgctgat gaataggttg ccttcagagt attattgaca gacagcttgt ggaactaatt     1500

ctttattttt gatgttgtgg gaattaacac atcaatggtg gttatgggaa ctaccaatgg     1560

gttcctacaa tttttatcag tagtatgtgg catatacacc ttcctagtgg cagttgccaa     1620

tgttaatgat tattcttttt attgcaagta tttcctatga tccttccaca ctttatttcc     1680

ttaataataa taaacttttt cagaaagaat tgagtagagc aaaaatgaca aagatgtgta     1740

gctgtgttca attttttttt tttttttttt ttgaggcaga gtcttgctct gctggagtgc     1800

ggtggtgcaa tctcggctca ctgcaacctc cacctcccag gttcaagcaa ttctcctgcc     1860

tcagtctcct gagtagctgg aactacaggt gtgcgccacc acgcccagct aatttttgta     1920

attttagtag agacagagtt tcaccatgtt ggccaggatg gtctcgatct cttgacctca     1980

tgatccaccc gcctcgacct cccaaagtgc tgtgattaca ggtgtgagcc actgcacccg     2040

gcctgaaatt tttttaaggt gaaaatgttt tgacaagttc ctttttcaga ataggttttt     2100

gagcagaact ctttcagctt gttagaccca actttgcttt tgtttagctt cacagcatag     2160

ctgaaagttg ccaaactgga cattgtgcaa taaagtagaa ttctatattg ataagcaaac     2220

tatttccaaa ctaaaaatgt gatagataaa agtgtgatta atcaaatgat atgatcagag     2280

taaagaattt tgccattttg atccttttac tttgttttag ccacctatag tgttaccaac     2340

catctttatc cttgtctgca gggataataa tgaactaatg tagtgtttta agataattta     2400

atgatactat ctttccaaac tttgttagat tttaaatgta ttattgacct gagaccttaa     2460

tgacaaatca ctgctattag acaattgaag tgttcattta ctttgtaatt ccaataatca     2520

tagttatgga attatggtaa ggttttgctt ttctgtccta ataaatatat atattttttg     2580

agatggagtt ttgctcttgt tgctgaggca ggagaattgc tcaaacccgg gaggcagagg     2640

ttgcagtgac ccaagatcgt gccacttcac tccagcctgg gcaaaagagc aaaacgccat     2700

ctcaaaaaat atacatatat aaggagataa agtttcccat tttccaatac agtttcacat     2760

ttgaacagcc ctaattgata caactttatg gcagggtttt agtgtgtgag tgggatccaa     2820

aacactcaat cctgtaaaag ggtacagtcc tattgtatgt taacacactg atgatgtgag     2880

cctgtgagat gagccaatca ccagttgtta tgttcgaatc tgctttgtgt tgggacgctt     2940

taatgtcagg gtttcactaa ataaatgaat tttcatatac tgaaaaaaaa aaaaaaaa       2998


<210>  21
<211>  589
<212>  DNA
<213>  Homo sapiens

<400>  21
accaaggcca gtcctgagca ggcccaactc cagtgcagct gcccaccctg ccgccatgtc       60

tctgaccaag actgagagga ccatcattgt gtccatgtgg gccaagatct ccacgcaggc      120

cgacaccatc ggcaccgaga ctctggagag gctcttcctc agccacccgc agaccaagac      180

ctacttcccg cacttcgacc tgcacccggg gtccgcgcag ttgcgcgcgc acggctccaa      240

ggtggtggcc gccgtgggcg acgcggtgaa gagcatcgac gacatcggcg gcgccctgtc      300

caagctgagc gagctgcacg cctacatcct gcgcgtggac ccggtcaact tcaagctcct      360

gtcccactgc ctgctggtca ccctggccgc gcgcttcccc gccgacttca cggccgaggc      420

ccacgccgcc tgggacaagt tcctatcggt cgtatcctct gtcctgaccg agaagtaccg      480

ctgagcgccg cctccgggac ccccaggaca ggctgcggcc cctcccccgt cctggaggtt      540

ccccagcccc acttaccgcg taatgcgcca ataaaccaat gaacgaagc                  589


<210>  22
<211>  1976
<212>  DNA
<213>  Homo sapiens

<400>  22
gagcggtcaa gggaaagaca agccgactct tcagatccct gtggacacac tgcctgctct       60

tccatatcat ggccctccac ccccgcagag tccggctaaa gccctggctg gtggcccagg      120

tggatagtgg cctctaccct gggctcatct ggctacacag ggactctaaa cgcttccaga      180

ttccctggaa acatgccacc cggcatagcc ctcaacaaga agaggaaaat accattttta      240

aggcctgggc tgtagagaca gggaagtacc aggaaggggt ggatgaccct gacccagcta      300

aatggaaggc ccagctgcgc tgtgctctca ataagagcag agaattcaac ctgatgtatg      360

atggcaccaa ggaggtgccc atgaacccag tgaagatata tcaagtgtgt gacatccctc      420

agccccaggg ctcgatcatt aacccaggat ccacagggtc tgctccctgg gatgagaagg      480

ataatgatgt ggatgaagaa gatgaggaag atgagctgga tcagtcgcag caccatgttc      540

ccatccagga caccttcccc ttcctgaaca tcaatggttc tcccatggcg ccagccagtg      600

tgggcaattg cagtgtgggc aactgcagcc cggaggcagt gtggcccaaa actgaacccc      660

tggagatgga agtaccccag gcacctatac agcccttcta tagctctcca gaactgtgga      720

tcagctctct cccaatgact gacctggaca tcaagtttca gtaccgtggg aaggagtacg      780

ggcagaccat gaccgtgagc aaccctcagg gctgccgact cttctatggg gacctgggtc      840

ccatgcctga ccaggaggag ctctttggtc ccgtcagcct ggagcaggtc aaattcccag      900

gtcctgagca tattaccaat gagaagcaga agctgttcac tagcaagctg ctggacgtca      960

tggacagagg actgatcctg gaggtcagcg gtcatgccat ttatgccatc aggctgtgcc     1020

agtgcaaggt gtactggtct gggccatgtg ccccatcact tgttgctccc aacctgattg     1080

agagacaaaa gaaggtcaag ctattttgtc tggaaacatt ccttagcgat ctcattgccc     1140

accagaaagg acagatagag aagcagccac cgtttgagat ctacttatgc tttggggaag     1200

aatggccaga tgggaaacca ttggaaagga aactcatctt ggttcaggtc attccagtag     1260

tggctcggat gatctacgag atgttttctg gtgatttcac acgatccttt gatagtggca     1320

gtgtccgcct gcagatctca accccagaca tcaaggataa catcgttgct cagctgaagc     1380

agctgtaccg catccttcaa acccaggaga gctggcagcc catgcagccc acccccagca     1440

tgcaactgcc ccctgccctg cctccccagt aattgtgaat gccatcttct tccttctctt     1500

ttttataata ttgtacatat ggattttttt attgtttaga tttaaccagc ttttaaatct     1560

ctcttttctc taacagtgtt agaagtttgt gattctccaa atatgcctag atttaaagct     1620

gatttaattt atggaaaaat cacccatcag actttgcttt tctttttcaa atctcctaat     1680

ggtagtatga tatagcatag tagaaggaga tttggcctgg gagtttggac accaaagttc     1740

tagctgcagc tttgcttcca atgtgacctt gaacaagtcc tttaacctct gggcttcaga     1800

tttattgctt ataaagtgaa gagattggag tagtgcctga aattgcatcc agctttagaa     1860

cggactcaat gaccttcttc tacttgtaca aggctaaact gcctggaaca gaatccttct     1920

gcattgttct tgtaccacat ttttccttgg ttttgttaaa gtttcctcaa gcacta         1976


<210>  23
<211>  1070
<212>  DNA
<213>  Homo sapiens

<400>  23
gtgggctcag cctcagagcc gtaggcgaga gcgcctgtct gcatgagtga gcacatgggt       60

gtttttgagt ctgtgggtgt cacagagagg agatcgggag ctgcctgctc acaggcactt      120

tgggaccccg aaagaaaagg ctgtgccgag agagttcttc cagtcagagg tgtcatgaag      180

actggacatg ggcctatcag ggccatgggc atgatgtcag ccaaggaact cgcggcctgc      240

ctctgccaag agaccagcat ctcggcctga gcactcccag cctcgcatcg ccttcaacct      300

ggctgcattc agctgccatg cccctacctc cttgtgtggt cagcaccctc caggacttca      360

tcttgggtca cccaaaggcc gaggacattg ctggccagca ggaaattcat ggtgcatcca      420

ggaagacttc caagaggtgg tggagcaggg ggcgccacac ccagacagct gtgtgtaatt      480

gcgcagctgc gggctgctgc gggtgctggc cggcagtgca ttctgggcac actggactgt      540

gtcaccgcat gcaggctgtg gccggagggg gaactgctgg ccgccaaggc ctatgtgcct      600

ggaaaccagc agggctgctg caggaggagg gctgcagaat gctccagctc agacctgact      660

cagggtttta gagggcatag ggtataaggc tgtggacata gacagcccta ctgcgcagga      720

agagcataaa ccagcccgag ggcatgcatg tgggctgctg ttagattctg ttctcctttg      780

aggtagggaa ggatgtgttt ctattttatg gatgagcaaa ctgaggcaga gtgctggagt      840

gatttccccc agcaacgatg gcagatttag ctccagggct tagattttag gatcctccct      900

ctcaaatacc atgatgtatc atgggctttc tctccacaga aaattagaaa ctcagaaatg      960

gaaagggaac aatgaaactt acccattctc ccactgctca catttccttc tggttttttt     1020

tgcgtgtgca tataaaatat atctcagaaa attgaaaaaa aaaaaaaaga                1070


<210>  24
<211>  1647
<212>  DNA
<213>  Homo sapiens

<400>  24
tcattcattg ccggcctgag gactcctagc tcggccccgc tccgcgctac agcccaaagc       60

ccagcctgag acccagccgc cctcgtatgc ccacggccta gctccccttc cctccaacag      120

acagactggg aaaaccgagt gggcgacggc tgagcaagga ctctccagtc ctcagtcacc      180

ttggacaaag aagtgtggat cctcagattc catcttttcc aactccaagg tgccatggca      240

gagaaggtgc tggtaacagg tggggctggc tacattggca gccacacggt gctggagctg      300

ctggaggctg gctacttgcc tgtggtcatc gataacttcc ataatgcctt ccgtggaggg      360

ggctccctgc ctgagagcct gcggcgggtc caggagctga caggccgctc tgtggagttt      420

gaggagatgg acattttgga ccagggagcc ctacagcgtc tcttcaaaaa gtacagcttt      480

atggcggtca tccactttgc ggggctcaag gccgtgggcg agtcggtgca gaagcctctg      540

gattattaca gagttaacct gaccgggacc atccagcttc tggagatcat gaaggcccac      600

ggggtgaaga acctggtgtt cagcagctca gccactgtgt acgggaaccc ccagtacctg      660

ccccttgatg aggcccaccc cacgggtggt tgtaccaacc cttacggcaa gtccaagttc      720

ttcatcgagg aaatgatccg ggacctgtgc caggcagaca agacttggaa cgcagtgctg      780

ctgcgctatt tcaaccccac aggtgcccat gcctctggct gcattggtga ggatccccag      840

ggcataccca acaacctcat gccttatgtc tcccaggtgg cgatcgggcg acgggaggcc      900

ctgaatgtct ttggcaatga ctatgacaca gaggatggca caggtgtccg ggattacatc      960

catgtcgtgg atctggccaa gggccacatt gcagccttaa ggaagctgaa agaacagtgt     1020

ggctgccgga tctacaacct gggcacgggc acaggctatt cagtgctgca gatggtccag     1080

gctatggaga aggcctctgg gaagaagatc ccgtacaagg tggtggcacg gcgggaaggt     1140

gatgtggcag cctgttacgc caaccccagc ctggcccaag aggagctggg gtggacagca     1200

gccttagggc tggacaggat gtgtgaggat ctctggcgct ggcagaagca gaatccttca     1260

ggctttggca cgcaagcctg aggaccctcc cctaccaagg accaggaaaa gcagcagctg     1320

cctgctctcc agcctctggc aggaactcag ggccctggag ctgctggggc caagccaagg     1380

cctcccctac ctcaaacccc agctgggccc gcttagccca ccaggcatga ggccaagggc     1440

tccactgacc aggaggccga ggtctctaac tcttatcttc cacagggtcc aagagttcat     1500

caggaccccc aagagtgagt gagggggcaa ggctctggca caaaacctcc tcctcccagg     1560

cactcattta tattgctctg aaagagcttt ccaaagtatt taaaaataaa aacaagtttt     1620

cttacactgg gaaaaaaaaa aaaaaaa                                         1647


<210>  25
<211>  777
<212>  DNA
<213>  Homo sapiens

<400>  25
cgaaggacta tggcagggga gaacttcgct acgccgttcc acgggcacgt gggccgcggc       60

gccttcagcg acgtgtacga gcccgcggag gacacgtttc tgcttttgga cgcgctcgag      120

gcagcggctg ccgaactggc aggagtggaa atatgcctgg aagtagggtc agggtctggt      180

gtagtatctg cattcctagc ctctatgata ggccctcagg ctttgtacat gtgcactgat      240

atcaaccctg aggcagcagc ttgtacccta gagacagcac gctgtaacaa agttcacatt      300

caaccagtta ttacagattt ggtaggaagt cacggaatag aggcagcttg ggctggtggc      360

agaaatggtc gggaagtcat ggacaggttt tttcccctgg ttccagatct cctttcacca      420

agaggattat tctatttagt taccattaaa gaaaacaacc cagaagaaat tttgaaaata      480

atgaagacaa aaggtctgca aggaaccact gcactttcca gacaagcagg ccaagaaact      540

ctttcagtcc tcaagttcac caagtcttag catacagtgt gtgcccagaa ctactggaaa      600

ctgaatgcat ttagcatatt ttgaaactga agtcattcat taggtaacaa ggaattttat      660

cagaaatttg tcattaaaaa aaggtagaaa ggtggaacat tccctttcag tcaggcctat      720

agaattattt gcacaagtac aagtaaatat gtgtattata aaaaaaaaaa aaaaaaa         777


<210>  26
<211>  5493
<212>  DNA
<213>  Homo sapiens

<400>  26
tcggtcctca gaggaggggc ccgggcaccc tccgtgcggg ccgcagcacg ccggtctttg       60

agggaccctt ggactcccgg atctgcatgc gagggatgcg gtcgaagacg agatgaggga      120

gctgacggga ggggaaacgg aggggcaggt gaacatggag agagcaggaa cagggagaga      180

gtagggacag cgactgggag acgcgctcca cagaaacccg gactgagagg cagcgagagg      240

acagagtctg gctctgtcgc ccaggcggga atgcagtggc gcaatcttgg ctcaccgcaa      300

cctctgcctc cctggttcaa gcaattctca tgcctcagcc tcccaagcag ctgggactac      360

agacatctga atgggactcc gagtgcctta catccctgca gccccttcct cttcctacac      420

ccccagcagc aaatgaggca cacctgcaga cagcagctat ctctctgtgg acagtggtgg      480

ccgccgtgca ggctatagag aggaaggtgg agatccacag ccggcgactc ctacacctgg      540

aaggtcggac agggacagca gagaagaaac tagccagctg tgaaaagaca gttaccgagc      600

ttgggaacca gctggagggc aagtgggccg tgctgggaac cctgctgcag gagtacgggc      660

tgctgcagag gcggctggag aacttggaga acctgctgcg caacaggaac ttctggatcc      720

tgcggctccc tccaggtatt aagggagata tcccaaaggt gcctgtggca tttgatgatg      780

tctccatcta cttttccact ccagagtggg aaaaattaga agaatggcaa aaggaacttt      840

acaagaatat catgaagggc aactacgagt ctctcatctc catggattat gctataaatc      900

aacctgatgt cttatctcag attcaaccag aaggggaaca taatacagag gaccaggcag      960

ggccagagga aagtgagatt cccacagacc ccagtgaaga gcctggtatt tcaacatcag     1020

atattctgtc ttggattaaa caagaagaag agcctcaggt tggggcccca ccggagtcca     1080

aggagagtga cgtgtacaaa agcacttatg ctgatgaaga gcttgtcatc aaagctgaag     1140

gccttgctag atcctcgttg tgccctgagg ttccagtccc tttctcttct ccaccagcag     1200

cagcaaagga tgctttttca gatgtggctt tcaaaagcca gcagtctaca tccatgacac     1260

cttttggacg tccagccact gacctgcctg aagcctctga gggacaagtg acttttactc     1320

agttgggtag ctatcccctc ccacctccag ttggcgagca ggtgttctca tgccaccact     1380

gtggcaagaa tctcagccaa gacatgttgc tgacccacca atgtagccat gctactgagc     1440

accccttacc ctgtgcccag tgccctaagc actttactcc acaggcggac ctcagcagca     1500

cctcccagga ccatgccagc gagacacccc ccacctgccc acactgtgcc aggactttta     1560

ctcacccatc aagacttacc taccatcttc gggtccataa cagcactgag cgtcctttcc     1620

cctgtcctga ttgccccaag cgctttgctg accaggctcg actcaccagc caccggagag     1680

ctcatgcaag cgaaaggccc ttccgctgtg cccagtgcgg caggagcttc agcttgaaaa     1740

tcagcctcct gctccaccag cggggtcatg cacaagagcg ccctttctcc tgccctcagt     1800

gtggcattga cttcaacggc cactcggccc tgatccgcca ccagatgatc cacacaggcg     1860

agcgtcctta cccctgcact gactgcagta agagcttcat gcgcaaggag cacctgctga     1920

accaccggcg gctgcacaca ggcgagcggc ccttcagttg tcctcactgt ggcaagagct     1980

tcatccgcaa gcaccaccta atgaaacacc agcgcatcca caccggggag cggccctacc     2040

cctgctccta ctgtggcagg agcttccgct acaaacagac actcaaggac cacctccgtt     2100

caggccacaa tggaggctgt gggggtgata gtgacccatc aggtcagcca cccaacccac     2160

caggtcccct cataactggg cttgaaactt ctggcctggg tgtcaacact gaaggtctag     2220

agaccaacca gtggtatggg gaagggagtg gagggggagt tttgtaaatc caaatctctg     2280

tggcttcatg cttgtatatg ctcacagcag ggcacaaaat ccaagagaag gtctgtgagc     2340

cccatccaac acccacagta attattatct ggcacatcaa tgaatttggg gtcctataca     2400

cttgactaga gacatgcttg tgttttggaa tttcacaccc ttacaagaat accacatttt     2460

gaaacccaga aagacctgga aaggagccca gcatgtccat cttttcaaag atacaacaaa     2520

agcagaagtt acaagaatat tgcggagagg ttggaaagca ggatttaacc tctagttctc     2580

ttgttctcag agaacagcag gttgatagta gattatgtct ctaggtagag acagatacat     2640

gagaagagcc tccaaaactg gaagcccatc ataaggcatg agaatgttta actataaagc     2700

cttttattag ttctttgata gctaagatgg ttgttggaga aagtgcttaa gccactgttt     2760

atgttgctgc ctcctctctc aaaaccagcc aagatctgtt cacacacctc tgtggctgtc     2820

tttccctgaa acatggtaac tcaagactgc ctgcctaggt ttcttagatt aattattcac     2880

ataaattttg tttaatattg gttgaacaag aaatctgact ttaaaagatt attaaggaga     2940

atattcctta actatactgg cttgatttga aacaggctct tattgccatt taaactgcca     3000

gaaatctttg ccaaggtcct ggttaaaaaa attggaaacg gttttcttag ccccagcttt     3060

aaaagctaga gatctcagag aaatagctgg cttaacaatg acagaacagc ttaaaatttg     3120

tgcctacacc atgttctgag agtcgttcac atcaaattct tatcttttcc aagccagtaa     3180

gttggcttct ccattcctgg tgtctgatat tcttgacaat catcagcaac aaagatcaca     3240

gcactttcca gaagcatgga gcttcagaaa gtgccagtga actcttggtc ctcagtagtg     3300

agatgataac agtgttataa tgcagcttcc ttgagccatc agagagagtg tatgttcacc     3360

ctatctggct gtatcccatt ggcagtggac agattgagga aattcctaga tcactgagag     3420

ctaagcacca tgcatagaca acagtttgtt cttgcctgtg ttgcttttag ggactttgac     3480

taccacatgt tcttttcttg gggtgattta atcacctggg agcatctgag tctgctccta     3540

agtggctttg caactgggcc taagttctgt ttcctttatg gatctcaaat tttcatctgc     3600

acaatgaggc tgttgaaagg aaaaaaagtg agcctctagg aattattcaa aaaaagtctg     3660

tgatacattc cttttcctgc caaagttctg tctctgtctt tggcttctgt ccaggcaaag     3720

ctaaataaga cagcaaagtc aaagcagata aattcttgtt gaaacttgac taaaatttat     3780

ttgatttgtt gttttactcc cacttggaat cctgaggtag aagacagaat gcagaagtct     3840

tacatcttgg gcaggaaact ggtttattcc tatactcttg tttcctctgc ttcttcctga     3900

ggtctagaac aaggtctgga aatgtttaga caggatattt tcttgatgaa gtgataagga     3960

aaggacccat ttttttgctc atcacctagc ccatccttca ctctctctag ttatgcataa     4020

caacactaga agaaggtgtt agcccagcta actttgcttc tgggaaggct atgtctgaac     4080

atgttgctct gtaggataat cacacttaga aaacatctgc tccatgacat tcacaatacc     4140

agggaccatg ggagacacaa gaaatgtgtg tctgctgtca taacttacag tgaaaaagcc     4200

caataataca gaacaagaca tgatgggcaa taccctagca tattgggatt aagagctttc     4260

tagccagaat ctggacctat accatgggaa aatttagggg tgctgggaat cccaaagcca     4320

aggttctggc ttcattggca acccactagg aacttgaatg tgagattcag ctctagtttg     4380

caccttgatt tccccagtga aaagggagaa gagccaaagt attgtctagg tgctgagttc     4440

ccttttctga gtggatttca agcatttgcc agggtatgct ggaggaggga ctcctaaagt     4500

aggtgagatg tgggactagg taacacttta aatacttttt tactcaaaga tttgccaaga     4560

acacagctta ttagtgaaag agacctgtgg attgaaatgg ctgcagatag atcccgcagt     4620

cccttctgaa aggaactgtg tagccagcag ggacctaaac tttggcaaaa agtgaacaca     4680

attcaaatac gaatgaagga agagccctca gatggaacga aaggcgatgt gcaaggccat     4740

cccagagaga cggaagcagg tgcgatacta agcctcagcc caagaataaa agagagttca     4800

actgttactc ttttctttca tcaatcccct atcagttaga actgcaggcc agttccaaag     4860

agtgtttgct taagattcaa aagtgggtaa gtaaaatgga tcagtgggaa ggataaggtg     4920

tccaacagaa agtgtggagg agaaactctt ggcctatcaa gtgctcctga gagaaaccat     4980

gcaatttaac acttcagtta aagaaataca tgagaactgc ttgtcatgac cagacaagat     5040

aggaaagggg aaaccccaga aacgtgctct tcatctgtca gccttttgga ccaagaagct     5100

gtcactatca cacataagca ccattccctt agagtggatc caggtgttga ctataaccag     5160

atttactctt tgcttactag gttttccatt gtcaccattg gatgaacctc tggtttagcc     5220

acagttgtga aaataaatgg aagttggttg attgtctaga aagtgcaaga agatggccct     5280

gctccttttc tgctgaacat ttagtattgg aaactcctac ttcccttttc attaataatg     5340

tgtgcaagtt tcctattagc ggggaaggtg tggggctctg ctgggcttct cttgagcata     5400

tctgagaaat gatgttcatg tctatctcaa ccaggaccag accctgtgac ttactcggta     5460

ataacagtcc acacaagcct cgttgatatt aaa                                  5493


<210>  27
<211>  1396
<212>  DNA
<213>  Homo sapiens

<400>  27
agaggttagt gcttaacatg tatctgggtg gggagctgct tttgctcccc actggtgctc       60

tggggagcca cgtggcctct ctttacacca aaactcccta tccaggtcca gctccactct      120

ccctctgccc cagcttccct gcagcccttt cctcttgctc tttgatgttt tgtaggcctg      180

cagctcccaa gcacagaggc atgagtgggg agaatgtcac cagggtcggc accttcatcc      240

tggtgggctt ccccacggcc ccagggctgc agtacctgct cttcctcctc ttcctgctca      300

cctacctctt tgtcctggtg gagaacctgg ccatcatcct caccgtctgg agcagcacct      360

ccctccacag gcccatgtac tactttctga gctccatgtc tttcctagag atctggtacg      420

tgtctgacat cacccccaag atgctggagg gcttcctcct ccagcagaaa cgcatctctt      480

tcgtcgggtg catgacgcag ctctacttct tcagctccct ggtgtgcacc gagtgtgtgc      540

ttctggcctc catggcctac gaccgctacg tggccatctg ccacccgctg cgctaccacg      600

tccttgtgac cccggggctg tgcctccagc tggtgggctt ctcctttgtg agtggcttca      660

ccatctccat gatcaaggtc tgttttatct ccagcgtcac gttctgtggc tccaacgtct      720

tgaaccactt cttctgtgac atttccccca tcctcaagct ggcctgcacg gacttctcca      780

ctgcagagct ggtggatttc attctggcct tcatcatcct ggtgtttcca ctcctggcca      840

ccatgctgtc atatgcgcac atcaccctgg ctgtcctgcg catcccctcg gccaccggct      900

gctggagagc cttcttcacc tgcgcctctc acctcaccgt ggtcaccgtc ttctatacag      960

ccttgctttt catgtatgtc cggccccagg ccattgattc ccggagctcc aacaagctca     1020

tctctgtttt gtacacagtt atcaccccca tcttgaaccc cttgatatac tgcctgagga     1080

ataaggaatt taagaatgcc ttgaaaaaag ccttcggctt gacgagctgc gccgtagagg     1140

ggaggctttc tagtcttctg gaacttcatc tccaaataca cagccagcct ctctgaggag     1200

gccatttgac tgtttgcatt attgtagtac cgcatttatt taaaaattac ttccaaatct     1260

atttttctcc ttcaggaaaa aaactgaggt tgaggttaat agcataggta ttgttgttgg     1320

tgttgtaata ccagtacttt cttgtttttg tagatgagca aagctgtagt tagtaaagct     1380

taatgaattt tcctcg                                                     1396


<210>  28
<211>  2850
<212>  DNA
<213>  Homo sapiens

<400>  28
tcgcacttcc gtgtgccgcg gcgccggagc ccgaggcggc tgtagcccac atctcccgag       60

cgacccccgg cgcccgcccg ccgcgcggag gcccgggcca cacctcactg gccgcttggc      120

ccatcccagt cagcgccgcg ccgaaccccg tccgcgcgcg ccggggagcg gcgcccccgc      180

cgctgccgcc gcgacccttg gcgcctgccc ctgcaacggg aggtctgcag ggaactggcc      240

aggcaagggg gcaggcccgt ttctcctggt ggttggtgcg ttgtagcagc agcgggagcc      300

aggactaagg acaagcagga gctgggagcc ccagccccac tgcaggcccc accatggcgc      360

cgttcctgcg catcgccttc aactcctatg agctgggctc cctgcaggcc gaggacgagg      420

cgaaccagcc cttctgtgcc gtgaagatga aggaggcgct cagcacagag cgtgggaaaa      480

cactggtgca gaagaagccg accatgtatc ctgagtggaa gtcgacgttc gatgcccaca      540

tctatgaggg gcgcgtcatc cagattgtgc taatgcgggc agcagaggag ccagtgtctg      600

aggtgaccgt gggtgtgtcg gtgctggccg agcgctgcaa gaagaacaat ggcaaggctg      660

agttctggct ggacctgcag cctcaggcca aggtgttgat gtctgttcag tatttcctgg      720

aggacgtgga ttgcaaacag tctatgcgca gtgaggacga ggccaagttc ccaacgatga      780

accgccgcgg agccatcaaa caggccaaaa tccactacat caagaaccat gagtttatcg      840

ccaccttctt tgggcaaccc accttctgtt ctgtgtgcaa agactttgtc tggggcctca      900

acaagcaagg ctacaaatgc aggcaatgta acgctgccat ccacaagaaa tgcatcgaca      960

agatcatcgg cagatgcact ggcaccgcgg ccaacagccg ggacactata ttccagaaag     1020

aacgcttcaa catcgacatg ccgcaccgct tcaaggttca caactacatg agccccacct     1080

tctgtgacca ctgcggcagc ctgctctggg gactggtgaa gcagggatta aagtgtgaag     1140

actgcggcat gaatgtgcac cataaatgcc gggagaaggt ggccaacctc tgcggcatca     1200

accagaagct tttggctgag gccttgaacc aagtcaccca gagagcctcc cggagatcag     1260

actcagcctc ctcagagcct gttgggatat atcagggttt cgagaagaag accggagttg     1320

ctggggagga catgcaagac aacagtggga cctacggcaa gatctgggag ggcagcagca     1380

agtgcaacat caacaacttc atcttccaca aggtcctggg caaaggcagc ttcgggaagg     1440

tgctgcttgg agagctgaag ggcagaggag agtactttgc catcaaggcc ctcaagaagg     1500

atgtggtcct gatcgacgac gacgtggagt gcaccatggt tgagaagcgg gtgctgacac     1560

ttgccgcaga gaatcccttt ctcacccacc tcatctgcac cttccagacc aaggaccacc     1620

tgttctttgt gatggagttc ctcaacgggg gggacctgat gtaccacatc caggacaaag     1680

gccgctttga actctaccgt gccacgtttt atgccgctga gataatgtgt ggactgcagt     1740

ttctacacag caagggcatc atttacaggg acctcaaact ggacaatgtg ctgctggacc     1800

gggatggcca catcaagatt gccgactttg ggatgtgcaa agagaacata ttcggggaga     1860

gccgggccag caccttctgc ggcacccctg actatatcgc ccctgagatc ctacagggcc     1920

tgaagtacac attctctgtg gactggtggt ctttcggggt ccttctgtac gagatgctca     1980

ttggccagtc ccccttccat ggtgatgatg aggatgaact cttcgagtcc atccgtgtgg     2040

acacgccaca ttatccccgc tggatcacca aggagtccaa ggacatcctg gagaagctct     2100

ttgaaaggga accaaccaag aggctgggag tgaccggaaa catcaaaatc caccccttct     2160

tcaagaccat aaactggact ctgctggaaa agcggaggtt ggagccacct ttcaggccca     2220

aagtgaagtc acccagagac tacagtaact ttgaccagga gttcctgaac gagaaggcgc     2280

gcctctccta cagcgacaag aacctcatcg actccatgga ccagtctgca ttcgctggct     2340

tctcctttgt gaaccccaaa ttcgagcacc tcctggaaga ttgaggttcc tggacagatc     2400

aggctagccc tgccctccac ccacacctgc ccgctcccca cgataagcac cagtgggact     2460

gtggtgactt ctgctgctgg ccccgcccct gcccccagag cgtccttggc tgccgtctgg     2520

ccgggctctc atggtacttc ctctgtgaac tgtgtgtgaa tctgcttttc ctctgccttc     2580

ggagggaaat tgtaaatcct gtgtttcatt acttgaatgt agttatctat tgaaaatata     2640

tattatatac atagacatat atatatatat aataggctgt atatattgct cagtagagaa     2700

aaaccatggg ggactggtga tatgttgatc tttttcaaaa aaatatatat atgacaaaaa     2760

aaaaaaaaaa ggagcacaag ctgtttgaac caccaggttt atttgtgtgt ctaaataaac     2820

accaaatagt accaaaaaaa aaaaaaaaaa                                      2850


<210>  29
<211>  1920
<212>  DNA
<213>  Homo sapiens

<400>  29
ggcacgaggg ggaatagtac taacaatgtc ccagcatctt cctctacagc tacagcttcc       60

acacagacgc agcattcggg aatgtccccg tcacctagca acagttatga tacttcccca      120

cagccttgca ctaccaatca aaatgggagg gagaataatg agcgattatc tacatccaat      180

ggaaagatgt caccaactcg ctaccatgca aacagcatgg gtcagaggtc atacagtttt      240

gaagcctcag aagaggacct agatgtagat gataaagtgg aagaattaat gaggagggac      300

agcagtgtga taaaagagga aatcaaagcc tttcttgcca atcggaggat ttcccaagca      360

gttgttgcac aggtaacagg tatcagtcag agccggatct ctcattggct gttgcagcag      420

ggatcagacc tgagtgaaca gaagaaaaga gcattttacc gatggtatca acttgagaag      480

acaaaccctg gcgctacact aagtatgaga ccagccccca ttccaataga ggaccctgaa      540

tggagacaaa cgcctccccc agtctctgcc acatctggta ctttccgact gcgacgaggg      600

agtcgattta cctggagaaa ggagtgcctg gctgttatgg aaagttactt caatgagaat      660

caatacccag atgaagcaaa gagggaagaa attgcaaacg cttgcaatgc agttatacag      720

aagccaggca aaaagctgtc agatctggaa agagttacct ccctgaaagt atataattgg      780

tttgctaaca gaaggaagga gatcaagagg agagccaata ttgcagcaat cctggagagt      840

catgggatag atgtgcagag tccaggaggc cactcaaaca gtgatgatgt cgacgggaat      900

gactactctg agcaggatac ttggcaagta cgcaatgggg aggaggagga gggaagaagt      960

tcagagggag gcagagaagc agagaaggta gaagaagaga ggaggatctg atccaaacaa     1020

gatgacagta cgagccatag tgaccaccaa gaccccatct cattagctgt ggaaatggca     1080

gcagtcaacc acactatctt ggcattggcc cgacaaggag ccaacgaaat caagacagag     1140

gccctggatg atgactgatc agggaggtta aacatgacaa gttaacttag tttagacgta     1200

gcaccttagc agactttcct cggtccttaa catgtgttct tacagtataa cttgcagttt     1260

cttgtatgtc aggtagctgt tagggtcttg ttctgtgaag atggcatggt gccctcagcc     1320

tttgcatata ctatctcagt attaactccc agtaaataat aaccaaccaa ccaaccaaac     1380

ttccctctcc cagcccccga ggctagaaaa tcttgctgct ccgtcttagc attccaagaa     1440

agtgcttcca ggtatttaga tagccctcag ttctcaaata ttagactacg tgtaaaatct     1500

tgggtacctt tagattcttg taacactagt ctgtactccc ttttccttcc ccaagactga     1560

taggatgcaa gctgaggtcg tggcacagga atgacagaca ccatttgggg agtatccaca     1620

gagtcaaagg aacactagaa tccccacctc agcgtgagga taattgattt ccagctgcaa     1680

taagccgtgc ctcattatag ccacactgtg gctagattat acttctttgg gtgctgtgct     1740

aagaatgtca atggaaaaag ccgatctcag attttgtttg aagttaacat gcctgacaca     1800

gacatccttt cctctcacaa gctgtgtgac ttagtagata aaatactgcc ttctgccttt     1860

gggaccatga ttaaaaacaa agacaaaaac caaaagtcat taaaaaaaaa aaaaaaaaaa     1920


<210>  30
<211>  1862
<212>  DNA
<213>  Homo sapiens

<400>  30
gcttgacaag tcaggattgt gcctccagtc agaaggacca tgaagagaga gaagagggca       60

gagccgtgca tggggctgct ccccaggacc tgagcaggaa cctggagttt tcagagctgc      120

ctgatcattg ctacagaatg aactctagcc cagctgggac cccaagtcca cagccctcca      180

gggccaatgg gaacatcaac ctggggcctt cagccaaccc aaatgcccag cccacggact      240

tcgacttcct caaagtcatc ggcaaaggga actacgggaa ggtcctactg gccaagcgca      300

agtctgatgg ggcgttctat gcagtgaagg tactacagaa aaagtccatc ttaaagaaga      360

aagagcagag ccacatcatg gcagagcgca gtgtgcttct gaagaacgtg cggcacccct      420

tcctcgtggg cctgcgctac tccttccaga cacctgagaa gctctacttc gtgctcgact      480

atgtcaacgg gggagagctc ttcttccacc tgcagcggga gcgccggttc ctggagcccc      540

gggccaggtt ctacgctgct gaggtggcca gcgccattgg ctacctgcac tccctcaaca      600

tcatttacag ggatctgaaa ccagagaaca ttctcttgga ctgccaggga cacgtggtgc      660

tgacggattt tggcctctgc aaggaaggtg tagagcctga agacaccaca tccacattct      720

gtggtacccc tgagtacttg gcacctgaag tgcttcggaa agagccttat gatcgagcag      780

tggactggtg gtgcttgggg gcagtcctct acgagatgct ccatggcctg ccgcccttct      840

acagccaaga tgtatcccag atgtatgaga acattctgca ccagccgcta cagatccccg      900

gaggccggac agtggccgcc tgtgacctcc tgcaaagcct tctccacaag gaccagaggc      960

agcggctggg ctccaaagca gactttcttg agattaagaa ccatgtattc ttcagcccca     1020

taaactggga tgacctgtac cacaagaggc taactccacc cttcaaccca aatgtgacag     1080

gacctgctga cttgaagcat tttgacccag agttcaccca ggaagctgtg tccaagtcca     1140

ttggctgtac ccctgacact gtggccagca gctctggggc ctcaagtgca ttcctgggat     1200

tttcttatgc gccagaggat gatgacatct tggattgcta gaagagaagg acctgtgaaa     1260

ctactgaggc cagctggtat tagtaaggaa ttaccttcag ctgctaggaa gagcgactca     1320

aactaacaat ggcttcaacg agaagcaggt ttattttttc cagcacataa aagaaaaata     1380

atgtttcgga gtccaggact ggcaggacag gtcatcagat actcagaggc tgtatctctg     1440

ccctgccaac cttgacaaat ggcttccaat gttaggtttg ctacaagatg gttactggag     1500

ctctagctgc ctattttgtg tttagggaag ggaaaatgga ggaaagggga gaagagcaaa     1560

gggcgctttt aaagagcttt cccaaaagct ccacccaatg acttctgctt ccatctcact     1620

aaccacccac ccctacctgg aatggaggct gggagatgtg gcttatttgc tgggtacgtg     1680

actatcccta ataacaaagg ggttctgaca ctaagacatt aggggagaat gttgggtagg     1740

cagccagcac tcttttacca gagggcctcc tggtgtttgg attttgatct caatgtgtaa     1800

aatgacagag atgtaacaag ctcatagggt atcaatatct cttattgttc tatgttgaaa     1860

aa                                                                    1862


<210>  31
<211>  1911
<212>  DNA
<213>  Homo sapiens

<400>  31
gtccgacggc gacatgggcg tccccacggc cctggaggcc ggcagctggc gctggggatc       60

cctgctcttc gctctcttcc tggctgcgtc cctaggtccg gtggcagcct tcaaggtcgc      120

cacgccgtat tccctgtatg tctgtcccga ggggcagaac gtcaccctca cctgcaggct      180

cttgggccct gtggacaaag ggcacgatgt gaccttctac aagacgtggt accgcagctc      240

gaggggcgag gtgcagacct gctcagagcg ccggcccatc cgcaacctca cgttccagga      300

ccttcacctg caccatggag gccaccaggc tgccaacacc agccacgacc tggctcagcg      360

ccacgggctg gagtcggcct ccgaccacca tggcaacttc tccatcacca tgcgcaacct      420

gaccctgctg gatagcggcc tctactgctg cctggtggtg gagatcaggc accaccactc      480

ggagcacagg gtccatggtg ccatggagct gcaggtgcag acaggcaaag atgcaccatc      540

caactgtgtg gtgtacccat cctcctccca ggagagtgaa aacatcacgg ctgcagccct      600

ggctacgggt gcctgcatcg taggaatcct ctgcctcccc ctcatcctgc tcctggtcta      660

caagcaaagg caggcagcct ccaaccgccg tgcccaggag ctggtgcgga tggacagcaa      720

cattcaaggg attgaaaacc ccggctttga agcctcacca cctgcccagg ggatacccga      780

ggccaaagtc aggcaccccc tgtcctatgt ggcccagcgg cagccttctg agtctgggcg      840

gcatctgctt tcggagccca gcacccccct gtctcctcca ggccccggag acgtcttctt      900

cccatccctg gaccctgtcc ctgactctcc aaactttgag gtcatctagc ccagctgggg      960

gacagtgggc tgttgtggct gggtctgggg caggtgcatt tgagccaggg ctggctctgt     1020

gagtggcctc cttggcctcg gccctggttc cctccctcct gctctgggct cagatactgt     1080

gacatcccag aagcccagcc cctcaacccc tctggatgct acatggggat gctggacggc     1140

tcagcccctg ttccaaggat tttggggtgc tgagattctc ccctagagac ctgaaattca     1200

ccagctacag atgccaaatg acttacatct taagaagtct cagaacgtcc agcccttcag     1260

cagctctcgt tctgagacat gagccttggg atgtggcagc atcagtggga caagatggac     1320

actgggccac cctcccaggc accagacaca gggcacggtg gagagacttc tcccccgtgg     1380

ccgccttggc tcccccgttt tgcccgaggc tgctcttctg tcagacttcc tctttgtacc     1440

acagtggctc tggggccagg cctgcctgcc cactggccat cgccacctta cccagctgcc     1500

tcctaccagc agtttctctg aagatctgtc aacaggttaa gtcaatctgg ggcttccact     1560

gcctgcattc cagtccccag agcttggtgg tcccgaaacg ggaagtacat attggggcat     1620

ggtggcctcc gtgagcaaat ggtgtcttgg gcaatctgag gccaggacag atgttgcccc     1680

acccactgga gatggtgctg agggaggtgg gtggggcctt ctgggaaggt gagtggagag     1740

gggcacctgc cccccgccct ccccatcccc tactcccact gctcagcgcg ggccattgca     1800

agggtgccac acaatgtctt gtccaccctg ggacacttct gagtatgaag cgggatgcta     1860

ttaaaaacta catggggaaa caggtgcaaa aaaaaaaaaa aaaaaaaaaa a              1911


<210>  32
<211>  6695
<212>  DNA
<213>  Homo sapiens

<400>  32
gccctcgccg cccgcggcgc cccgagcgct ttgtgagcag atgcggagcc gagtggaggg       60

cgcgagccag atgcggggcg acagctgact tgctgagagg aggcggggag gcgcggagcg      120

cgcgtgtggt ccttgcgccg ctgacttctc cactggttcc tgggcaccga aagataaacc      180

tctcataatg aaggcccccg ctgtgcttgc acctggcatc ctcgtgctcc tgtttacctt      240

ggtgcagagg agcaatgggg agtgtaaaga ggcactagca aagtccgaga tgaatgtgaa      300

tatgaagtat cagcttccca acttcaccgc ggaaacaccc atccagaatg tcattctaca      360

tgagcatcac attttccttg gtgccactaa ctacatttat gttttaaatg aggaagacct      420

tcagaaggtt gctgagtaca agactgggcc tgtgctggaa cacccagatt gtttcccatg      480

tcaggactgc agcagcaaag ccaatttatc aggaggtgtt tggaaagata acatcaacat      540

ggctctagtt gtcgacacct actatgatga tcaactcatt agctgtggca gcgtcaacag      600

agggacctgc cagcgacatg tctttcccca caatcatact gctgacatac agtcggaggt      660

tcactgcata ttctccccac agatagaaga gcccagccag tgtcctgact gtgtggtgag      720

cgccctggga gccaaagtcc tttcatctgt aaaggaccgg ttcatcaact tctttgtagg      780

caataccata aattcttctt atttcccaga tcatccattg cattcgatat cagtgagaag      840

gctaaaggaa acgaaagatg gttttatgtt tttgacggac cagtcctaca ttgatgtttt      900

acctgagttc agagattctt accccattaa gtatgtccat gcctttgaaa gcaacaattt      960

tatttacttc ttgacggtcc aaagggaaac tctagatgct cagacttttc acacaagaat     1020

aatcaggttc tgttccataa actctggatt gcattcctac atggaaatgc ctctggagtg     1080

tattctcaca gaaaagagaa aaaagagatc cacaaagaag gaagtgttta atatacttca     1140

ggctgcgtat gtcagcaagc ctggggccca gcttgctaga caaataggag ccagcctgaa     1200

tgatgacatt cttttcgggg tgttcgcaca aagcaagcca gattctgccg aaccaatgga     1260

tcgatctgcc atgtgtgcat tccctatcaa atatgtcaac gacttcttca acaagatcgt     1320

caacaaaaac aatgtgagat gtctccagca tttttacgga cccaatcatg agcactgctt     1380

taataggaca cttctgagaa attcatcagg ctgtgaagcg cgccgtgatg aatatcgaac     1440

agagtttacc acagctttgc agcgcgttga cttattcatg ggtcaattca gcgaagtcct     1500

cttaacatct atatccacct tcattaaagg agacctcacc atagctaatc ttgggacatc     1560

agagggtcgc ttcatgcagg ttgtggtttc tcgatcagga ccatcaaccc ctcatgtgaa     1620

ttttctcctg gactcccatc cagtgtctcc agaagtgatt gtggagcata cattaaacca     1680

aaatggctac acactggtta tcactgggaa gaagatcacg aagatcccat tgaatggctt     1740

gggctgcaga catttccagt cctgcagtca atgcctctct gccccaccct ttgttcagtg     1800

tggctggtgc cacgacaaat gtgtgcgatc ggaggaatgc ctgagcggga catggactca     1860

acagatctgt ctgcctgcaa tctacaaggt tttcccaaat agtgcacccc ttgaaggagg     1920

gacaaggctg accatatgtg gctgggactt tggatttcgg aggaataata aatttgattt     1980

aaagaaaact agagttctcc ttggaaatga gagctgcacc ttgactttaa gtgagagcac     2040

gatgaataca ttgaaatgca cagttggtcc tgccatgaat aagcatttca atatgtccat     2100

aattatttca aatggccacg ggacaacaca atacagtaca ttctcctatg tggatcctgt     2160

aataacaagt atttcgccga aatacggtcc tatggctggt ggcactttac ttactttaac     2220

tggaaattac ctaaacagtg ggaattctag acacatttca attggtggaa aaacatgtac     2280

tttaaaaagt gtgtcaaaca gtattcttga atgttatacc ccagcccaaa ccatttcaac     2340

tgagtttgct gttaaattga aaattgactt agccaaccga gagacaagca tcttcagtta     2400

ccgtgaagat cccattgtct atgaaattca tccaaccaaa tcttttatta gtacttggtg     2460

gaaagaacct ctcaacattg tcagttttct attttgcttt gccagtggtg ggagcacaat     2520

aacaggtgtt gggaaaaacc tgaattcagt tagtgtcccg agaatggtca taaatgtgca     2580

tgaagcagga aggaacttta cagtggcatg tcaacatcgc tctaattcag agataatctg     2640

ttgtaccact ccttccctgc aacagctgaa tctgcaactc cccctgaaaa ccaaagcctt     2700

tttcatgtta gatgggatcc tttccaaata ctttgatctc atttatgtac ataatcctgt     2760

gtttaagcct tttgaaaagc cagtgatgat ctcaatgggc aatgaaaatg tactggaaat     2820

taagggaaat gatattgacc ctgaagcagt taaaggtgaa gtgttaaaag ttggaaataa     2880

gagctgtgag aatatacact tacattctga agccgtttta tgcacggtcc ccaatgacct     2940

gctgaaattg aacagcgagc taaatataga gtggaagcaa gcaatttctt caaccgtcct     3000

tggaaaagta atagttcaac cagatcagaa tttcacagga ttgattgctg gtgttgtctc     3060

aatatcaaca gcactgttat tactacttgg gtttttcctg tggctgaaaa agagaaagca     3120

aattaaagat ctgggcagtg aattagttcg ctacgatgca agagtacaca ctcctcattt     3180

ggataggctt gtaagtgccc gaagtgtaag cccaactaca gaaatggttt caaatgaatc     3240

tgtagactac cgagctactt ttccagaaga tcagtttcct aattcatctc agaacggttc     3300

atgccgacaa gtgcagtatc ctctgacaga catgtccccc atcctaacta gtggggactc     3360

tgatatatcc agtccattac tgcaaaatac tgtccacatt gacctcagtg ctctaaatcc     3420

agagctggtc caggcagtgc agcatgtagt gattgggccc agtagcctga ttgtgcattt     3480

caatgaagtc ataggaagag ggcattttgg ttgtgtatat catgggactt tgttggacaa     3540

tgatggcaag aaaattcact gtgctgtgaa atccttgaac agaatcactg acataggaga     3600

agtttcccaa tttctgaccg agggaatcat catgaaagat tttagtcatc ccaatgtcct     3660

ctcgctcctg ggaatctgcc tgcgaagtga agggtctccg ctggtggtcc taccatacat     3720

gaaacatgga gatcttcgaa atttcattcg aaatgagact cataatccaa ctgtaaaaga     3780

tcttattggc tttggtcttc aagtagccaa aggcatgaaa tatcttgcaa gcaaaaagtt     3840

tgtccacaga gacttggctg caagaaactg tatgctggat gaaaaattca cagtcaaggt     3900

tgctgatttt ggtcttgcca gagacatgta tgataaagaa tactatagtg tacacaacaa     3960

aacaggtgca aagctgccag tgaagtggat ggctttggaa agtctgcaaa ctcaaaagtt     4020

taccaccaag tcagatgtgt ggtcctttgg cgtgctcctc tgggagctga tgacaagagg     4080

agccccacct tatcctgacg taaacacctt tgatataact gtttacttgt tgcaagggag     4140

aagactccta caacccgaat actgcccaga ccccttatat gaagtaatgc taaaatgctg     4200

gcaccctaaa gccgaaatgc gcccatcctt ttctgaactg gtgtcccgga tatcagcgat     4260

cttctctact ttcattgggg agcactatgt ccatgtgaac gctacttatg tgaacgtaaa     4320

atgtgtcgct ccgtatcctt ctctgttgtc atcagaagat aacgctgatg atgaggtgga     4380

cacacgacca gcctccttct gggagacatc atagtgctag tactatgtca aagcaacagt     4440

ccacactttg tccaatggtt ttttcactgc ctgaccttta aaaggccatc gatattcttt     4500

gctcttgcca aaattgcact attataggac ttgtattgtt atttaaatta ctggattcta     4560

aggaatttct tatctgacag agcatcagaa ccagaggctt ggtcccacag gccacggacc     4620

aatggcctgc agccgtgaca acactcctgt catattggag tccaaaactt gaattctggg     4680

ttgaattttt taaaaatcag gtaccacttg atttcatatg ggaaattgaa gcaggaaata     4740

ttgagggctt cttgatcaca gaaaactcag aagagatagt aatgctcagg acaggagcgg     4800

cagccccaga acaggccact catttagaat tctagtgttt caaaacactt ttgtgtgttg     4860

tatggtcaat aacatttttc attactgatg gtgtcattca cccattaggt aaacattccc     4920

ttttaaatgt ttgtttgttt tttgagacag gatctcactc tgttgccagg gctgtagtgc     4980

agtggtgtga tcatagctca ctgcaacctc cacctcccag gctcaagcct cccgaatagc     5040

tgggactaca ggcgcacacc accatccccg gctaattttt gtattttttg tagagacggg     5100

gttttgccat gttgccaagg ctggtttcaa actcctggac tcaagaaatc cacccacctc     5160

agcctcccaa agtgctagga ttacaggcat gagccactgc gcccagccct tataaatttt     5220

tgtatagaca ttcctttggt tggaagaata tttataggca atacagtcaa agtttcaaaa     5280

tagcatcaca caaaacatgt ttataaatga acaggatgta atgtacatag atgacattaa     5340

gaaaatttgt atgaaataat ttagtcatca tgaaatattt agttgtcata taaaaaccca     5400

ctgtttgaga atgatgctac tctgatctaa tgaatgtgaa catgtagatg ttttgtgtgt     5460

atttttttaa atgaaaactc aaaataagac aagtaatttg ttgataaata tttttaaaga     5520

taactcagca tgtttgtaaa gcaggataca ttttactaaa aggttcattg gttccaatca     5580

cagctcatag gtagagcaaa gaaagggtgg atggattgaa aagattagcc tctgtctcgg     5640

tggcaggttc ccacctcgca agcaattgga aacaaaactt ttggggagtt ttattttgca     5700

ttagggtgtg ttttatgtta agcaaaacat actttagaaa caaatgaaaa aggcaattga     5760

aaatcccagc tatttcacct agatggaata gccaccctga gcagaacttt gtgatgcttc     5820

attctgtgga attttgtgct tgctactgta tagtgcatgt ggtgtaggtt actctaactg     5880

gttttgtcga cgtaaacatt taaagtgtta tattttttat aaaaatgttt atttttaatg     5940

atatgagaaa aattttgtta ggccacaaaa acactgcact gtgaacattt tagaaaaggt     6000

atgtcagact gggattaatg acagcatgat tttcaatgac tgtaaattgc gataaggaaa     6060

tgtactgatt gccaatacac cccaccctca ttacatcatc aggacttgaa gccaagggtt     6120

aacccagcaa gctacaaaga gggtgtgtca cactgaaact caatagttga gtttggctgt     6180

tgttgcagga aaatgattat aactaaaagc tctctgatag tgcagagact taccagaaga     6240

cacaaggaat tgtactgaag agctattaca atccaaatat tgccgtttca taaatgtaat     6300

aagtaatact aattcacaga gtattgtaaa tggtggatga caaaagaaaa tctgctctgt     6360

ggaaagaaag aactgtctct accagggtca agagcatgaa cgcatcaata gaaagaactc     6420

ggggaaacat cccatcaaca ggactacaca cttgtatata cattcttgag aacactgcaa     6480

tgtgaaaatc acgtttgcta tttataaact tgtccttaga ttaatgtgtc tggacagatt     6540

gtgggagtaa gtgattcttc taagaattag atacttgtca ctgcctatac ctgcagctga     6600

actgaatggt acttcgtatg ttaatagttg ttctgataaa tcatgcaatt aaagtaaagt     6660

gatgcaacat cttgtaaaaa aaaaaaaaaa aaaaa                                6695


<210>  33
<211>  756
<212>  DNA
<213>  Homo sapiens

<400>  33
gggaattccc tgagacacac acctccaatg ccaagcaccg aacctgatag cccatctcac       60

agatgacagc aatcagtgtc atcaaccgca tcacaccagt cctccaagac acagcattta      120

taacgtcagg ctgtgaccac caacaaacag aaaaaaacaa agtaataaaa tatcccaggt      180

cacgcttgga tgctaaaatc aagcagtcgt ggaataaaga aagtcacttt cagggcaact      240

atgtaaaatc agtcgtggcc tttgggcagc ctagaggaga actcagtcag ccacggctcc      300

taaccctgcc ccacaccctg agtgtctatg aggggtcacc cagaaatcag ttaccaccgg      360

gacgttttgt tccgttcaaa aaccagccgt gtgggggcat cctgggtctg gggcagatga      420

ctgtttcccc aaaatatctc catgcccaag gaacagctcc ctttatccca gcagcaggat      480

ctggtcctcc gaactcaccc actaaccttc caagcaaagt tgtaaataat aaagacttcc      540

tctgtggcaa gtcctgttct aagctctgta cagatgagag tacaaattag cttcttacat      600

ttcatcctca tgaaaaccca aggatgtgga tggagtattt attattctca ttttaagtat      660

ggggaaactg aggcaccgag cagcatcttg tcacacctaa gatcactcgc atgtaaacaa      720

cggggctgag attcagagct ggacagtgga ggtccc                                756


<210>  34
<211>  2266
<212>  DNA
<213>  Homo sapiens

<400>  34
gttggctgcc gaggctcggc cggagcgtgg agcccgcgcc gctgccccag gaccgcgccc       60

gcgcctttgt ccgccgccgc ccaccgcccg tcgcccgccg cccatggagc gcgccgcgcc      120

gtcgcgccgg gtcccgcttc agctgctgct gctcggcggc cttgcgctgc tggcggccgg      180

agtggacgcg gatgtcctcc tggaggcctg ctgtgcggac ggacaccgga tggccactca      240

tcagaaggac tgctcgctgc catatgctac ggaatccaaa gaatgcagga tggtgcagga      300

gcagtgctgc cacagccagc tggaggagct gcactgtgcc acgggcatca gcctggccaa      360

cgagcaggac cgctgtgcca cgccccacgg tgacaacgcc agcctggagg ccacatttgt      420

gaagaggtgc tgccattgct gtctgctggg gagggcggcc caggcccagg gccagagctg      480

cgagtacagc ctcatggttg gctaccagtg tggacaggtc ttccgggcat gctgtgtcaa      540

gagccaggag accggagatt tggatgtcgg gggcctccaa gaaacggata agatcattga      600

ggttgaggag gaacaagagg acccatatct gaatgaccgc tgccgaggag gcgggccctg      660

caagcagcag tgccgagaca cgggtgacga ggtggtctgc tcctgcttcg tgggctacca      720

gctgctgtct gatggtgtct cctgtgaaga tgtcaatgaa tgcatcacgg gcagccacag      780

ctgccggctt ggagaatcct gcatcaacac agtgggctct ttccgctgcc agcgggacag      840

cagctgcggg actggctatg agctcacaga ggacaatagc tgcaaagata ttgacgagtg      900

tgagagtggt attcataact gcctccccga ttttatctgt cagaatactc tgggatcctt      960

ccgctgccga cccaagctac agtgcaagag tggctttata caagatgctc taggcaactg     1020

tattgatatc aatgagtgtt tgagtatcag tgccccgtgc cctatcgggc atacatgcat     1080

caacacagag ggctcctaca cgtgccagaa gaacgtgccc aactgtggcc gtggctacca     1140

tctcaacgag gagggaacgc gctgtgttga tgtggacgag tgcgcgccac ctgctgagcc     1200

ctgtgggaag ggacatcgct gcgtgaactc tcccggcagt ttccgctgcg aatgcaagac     1260

gggttactat tttgacggca tcagcaggat gtgtgtcgat gtcaacgagt gccagcgcta     1320

ccccgggcgc ctgtgtggcc acaagtgcga gaacacgctg ggctcctacc tctgcagctg     1380

ttccgtgggc ttccggctct ctgtggatgg caggtcatgt gaagacatca atgagtgcag     1440

cagcagcccc tgtagccagg agtgtgccaa cgtctacggc tcctaccagt gttactgccg     1500

gcgaggctac cagctcagcg atgtggatgg agtcacctgt gaagacatcg acgagtgcgc     1560

cctgcccacc gggggccaca tctgctccta ccgctgcatc aacatccctg gaagcttcca     1620

gtgcagctgc ccctcgtctg gctacaggct ggcccccaat ggcagcaact gccaagacat     1680

tgatgagtgt gtgactggca tccacaactg ctccatcaac gagacctgct tcaacatcca     1740

gggcggcttc cgctgcctgg ccttcgagtg ccctgagaac taccgccgct ccgcagccac     1800

ccgctgtgag cgcttgcctt gccatgagaa tcgggagtgc tccaagctgc ctctgagaat     1860

aacctactac cacctctctt tccccaccaa catccaagcg cccgcggtgg ttttccgcat     1920

gggcccctcc agtgctgtcc ccggggacag catgcagctg gccatcaccg gcggcaatga     1980

ggagggcttt ttcaccaccc ggaaggtgag cccccacagt ggggtggtgg ccctcaccaa     2040

gcctgtcccc gagcccaggg acttgctcct gaccgtcaag atggatctct ctcgccacgg     2100

caccgtcagc tcctttgtgg ccaagctttt catctttgtg tctgcagagc tctgagcact     2160

cgcttcgcgt cgcggggtct ccctcctgtt gctttcctaa ccctgccctc cggggcgtta     2220

ataaagtctt agcaagcgtc ccacacagcg aaaaaaaaaa aaaaaa                    2266


<210>  35
<211>  921
<212>  DNA
<213>  Homo sapiens

<400>  35
gcggcgctcg cgccaaggga cgtgtttctg cgctcgcgtg gtcatggagg cgctgccgct       60

gctagccgcg acaactccgg accacggccg ccaccgaagg ctgcttctgc tgccgctact      120

gctgttcctg ctgccggctg gagctgtgca gggctgggag acagaggaga ggccccggac      180

tcgcgaagag gagtgccact tctacgcggg tggacaagtg tacccgggag aggcatcccg      240

ggtatcggtc gccgaccact ccctgcacct aagcaaagcg aagatttcca agccagcgcc      300

ctactgggaa ggaacagctg tgatcgatgg agaatttaag gagctgaagt taactgatta      360

tcgtgggaaa tacttggttt tcttcttcta cccacttgat ttcacatttg tgtgtccaac      420

tgaaattatc gcttttggcg acagacttga agaattcaga tctataaata ctgaagtggt      480

agcatgctct gttgattcac agtttaccca tttggcctgg attaataccc ctcgaagaca      540

aggaggactt gggccaataa ggattccact tctttcagat ttgacccatc agatctcaaa      600

ggactatggt gtatacctag aggactcagg ccacactctt agaggtctct tcattattga      660

tgacaaagga atcctaagac aaattactct gaatgatctt cctgtgggta gatcagtgga      720

tgagacacta cgtttggttc aagcattcca gtacactgac aaacacggag aagtctgccc      780

tgctggctgg aaacctggta gtgaaacaat aatcccagat ccagctggaa agctgaagta      840

tttcgataaa ctgaattgag aaatacttct tcaagttatg atgcttgaaa gttctcaata      900

aagttcacgg tttcattacc a                                                921


<210>  36
<211>  966
<212>  DNA
<213>  Homo sapiens

<400>  36
atgtccttac agaaactcat ggagccagaa gctgggacca ataggaccgc tgttgctgag       60

ttcattctac tgggcctagt gcaaacagaa gagatgcagc cagttgtctt tgtgctcctc      120

ctctttgcct atctggtcac aattgggggc aacctcagca tcctggcagc cgtcttggtg      180

gagcccaaac tccacgcccc catgtacttc ttcctgggga acctatcagt gctggatgtc      240

ggatgtatca ctgtcactgt tcctgcaatg ttgggtcgtc tcttgtccca caagtccaca      300

atttcctatg acgcctgcct ctcccagctc ttcttcttcc accttctggc tgggatggac      360

tgcttcctgc tgaccgccat ggcctatgac cgactcctgg ccatctgcca gcccctcacc      420

tacagcaccc gcatgagtca gacagtccag aggatgttgg tggctgcgtc ctgggcttgt      480

gccttcacca acgcactgac ccacactgtg gccatgtcca cgctcaactt ctgtggcccc      540

aatgaggtca atcacttcta ctgtgacctc ccacagctct tccagctctc ctgctccagc      600

acccaactca atgagctgct gctctttgta gcagcagcct tcatggctgt ggcacccttg      660

gtcttcatca gtgtgtccta tgcccatgtg gtagctgctg tgctgcaaat ccgctctgct      720

gagggcagaa agaaggcctt ctccacatgt ggctcccacc tcactgtggt gggcatcttc      780

tatgggacag gtgtcttcag ctacatgagg ctgggttcag tggaatcttc agacaaggat      840

aagggggttg gggttttcat gactgtgatc aaccccatgc tgaacccact tatctacagc      900

ctcagaaata ctgatgttca gggcgctctg tgtcagctac ttgtggggga gcgatcactg      960

acctga                                                                 966


<210>  37
<211>  1835
<212>  DNA
<213>  Homo sapiens

<400>  37
aatacatcat aaatcgtgaa gcacagggtt ataacgacca cgatccacaa atcaagccct       60

ccaaaatcac ccaaatgagc tcgtactttg taaactcctt ctcggggcgt tatccaaatg      120

gcccggacta tcagttgcta aattatggca gtggcagctc tctgagcggc tcttacaggg      180

atcccgctgc catgcacacc ggctcttacg gctacaatta caatgggatg gacctcagcg      240

tcaaccgctc ctcggcctcc tccagccact ttggggcggt gggcgagagc tcgcgcgcct      300

tccccgcgcc cgcccaggag ccccgcttca ggcaagcggc ttcgagctgc tccctgtcct      360

cgcccgagtc cctgccctgc accaacggcg acagccacgg cgccaagccc tctgcttcgt      420

ccccctccga ccaggcgacc tcagccagct ccagcgccaa tttcaccgaa atagacgagg      480

ccagcgcgtc ctcggagcct gaggaagcgg caagccagct aagcagcccc agcctagctc      540

gggcgcagcc agagcccatg gccacctcca cagccgcgcc cgaggggcag actccgcaga      600

tattcccctg gatgaggaag cttcacatca gccatgatat gaccgggccg gacgggaaaa      660

gggcccggac cgcgtatacc cgctaccaga ccctggagct ggaaaaggag ttccacttca      720

accgctacct gacccggcga cggcgcatcg agatcgccca cgcactctgc ctgtccgagc      780

gccagatcaa gatctggttc cagaaccggc gcatgaagtg gaagaaggac aacaaattga      840

aaagtatgag cctggctaca gctggcagcg ccttccagcc ctgagcccgc ccagaggagc      900

ccagcggccc aagagcccgt gccaccccca gccctggccc ctccaatcct ccccgctctg      960

ccgccgcccg ctggggaccg gttcccacaa gcctgcctcg ccttgtgtta cgatatttcg     1020

tttgatctta ggtcttcctg tggctccctc tctcctggac tggttatctt gttattattg     1080

ttaataataa taattattat tattttcctt ccatgctccc aactcccttc tgcttgtccc     1140

aaatccgcca gtgtttctga atgtttgtgt ctgtggttgc agtctttccc ccaggaaaaa     1200

aaaaaaaaga aattcgcatg tttaatgtga actctcccct ccccatctgt gttctaactt     1260

atttataaaa agatgatcgc tgtattttga gtttcagctg gaaacttctg taaggggcag     1320

cagttgaggt ggggtagtgc cgcagtgggg tcaagctgag ctggcttcgg agatggagtc     1380

ccttttcatt ctcctcctcc tccctcctca ctccctaggc ccaagtctcc taggggcttg     1440

gtcctagggt gggaaggggc tagggaggac caaagggatg gtattgagaa gagagaaaga     1500

agatagtgag atttaagttc ctgctgcctg ggtaggcccc acaaggcctg gtctgggagt     1560

atacggaaac aaaaatgatc ctcagtgcaa aatgtcttgt gtatttctct gtgaatccat     1620

gggtctggct agagggccca aagcttgtaa atatggggat agtctgggtc agacccatct     1680

ctcccttacc catcttgctt ccaagaccat ttgtagtgag cgagtggatg ctgtgctacg     1740

tgtgaaatct gtctttgcgg ggcctgtctc agtgattcgc ttttggtatt tgtttgtagc     1800

tttcctggaa gtcaaataaa tgtttccccc actcc                                1835


<210>  38
<211>  1345
<212>  DNA
<213>  Homo sapiens

<400>  38
cggacgcgtg gggtggcggc ggcgaaggtg gcggcggctc ggccagtact cccggccccc       60

gccatttcgg actgggagcg agcgcggcgc aggcactgaa ggcggcggcg gggccagagg      120

ctcagcggct cccaggtgcg ggagagaggc ctgctgaaaa tgactgaata taaacttgtg      180

gtagttggag ctggtggcgt aggcaagagt gccttgacga tacagctaat tcagaatcat      240

tttgtggacg aatatgatcc aacaatagag gattcctaca ggaagcaagt agtaattgat      300

ggagaaacct gtctcttgga tattctcgac acagcaggtc atgaggagta cagtgcaatg      360

agggaccagt acatgaggac tggggagggc tttctttgtg tatttgccat aaataatact      420

aaatcatttg aagatattca ccattataga gaacaaatta aaagagttaa ggactctgaa      480

gatgtaccta tggtcctagt aggaaataaa tgtgatttgc cttctagaac agtagacaca      540

aaacaggctc aggacttagc aagaagttat ggaattcctt ttattgaaac atcagcaaag      600

acaagacagg gtgttgatga tgccttctat acattagttc gagaaattcg aaaacataaa      660

gaaaagatga gcaaagatgg taaaaagaag aaaaagaagt caaagacaaa gtgtgtaatt      720

atgtaaatac aatttgtact tttttcttaa ggcatactag tacaagtggt aatttttgta      780

cattacacta aattattagc atttgtttta gcattaccta atttttttcc tgctccatgc      840

agactgttag cttttacctt aaatgcttat tttaaaatga cagtggaagt ttttttttcc      900

tcgaagtgcc agtattccca gagttttggt ttttgaacta gcaatgcctg tgaaaaagaa      960

actgaatacc taagatttct gtcttggggt ttttggtgca tgcagttgat tacttcttat     1020

ttttcttacc aattgtgaat gttggtgtga aacaaattaa tgaagctttt gaatcatccc     1080

tattctgtgt tttatctagt cacataaatg gattaattac taatttcagt tgagaccttc     1140

taattggttt ttactgaaac attgagggaa cacaaattta tgggcttcct gatgatgatt     1200

cttctaggca tcatgtccta tagtttgtca tccctgacga atgtaaagtt acactgttca     1260

caaaggtttt gtctcctttc cactgctatt agtcatggtc actctcccca aaatattata     1320

ttttttctat aaaaaaaaaa aaaaa                                           1345


<210>  39
<211>  2427
<212>  DNA
<213>  Homo sapiens

<400>  39
cctcaagtct ctttcctcac ttctttctct tcacttaaaa caattttttt ggaggggttt       60

tggggaggaa gtgagcggac gctggggatg ggtctcgtaa gcggccggat tgagaggagg      120

gaggaagcag ggggcttccg agtgggtgac ccagacgcgg gctgtggggt ggggcagttc      180

gtggggtccg gtcctggaaa ggcgtcgact gccccccaac tcttctggtt tcctctacga      240

tgagcggaag gtttgaatcc tggaggtggg gtctccggtg tggagttctg gaaactgtga      300

ggtgatttgc agctggtgga atggaacagt gaagaagcat tggaatggta gataacgcag      360

atcatctctg gaaaggatat tgatccgcct catgtaaagt atgcttagtt cctttccagt      420

ggttttgctg gaaaccatgt ctcattatac agatgaaccc agatttacca tagagcagat      480

agatctgctt cagcgacttc ggcgtactgg aatgactaaa catgaaattc tccatgcctt      540

ggaaactttg gaccgtcttg atcaagagca tagtgacaag tttggaagaa ggtccagcta      600

tggaggaagt tcatatggga atagtactaa caatgtccca gcatcttcct ctacagctac      660

agcttccaca cagacgcagc attcgggaat gtccccgtca cctagcaaca gttatgatac      720

ttccccacag ccttgcacta ccaatcaaaa tgggagggag aataatgagc gattatctac      780

atccaatgga aagatgtcac caactcgcta ccatgcaaac agcatgggtc agaggtcata      840

cagttttgaa gcctcagaag aggacctaga tgtagatgat aaagtggaag aattaatgag      900

gagggacagc agtgtgataa aagaggaaat caaagccttt cttgccaatc ggaggatttc      960

ccaagcagtt gttgcacagg taacaggtat cagtcagagc cggatctctc attggctgtt     1020

gcagcaggga tcagacctga gtgaacagaa gaaaagagca ttttaccgat ggtatcaact     1080

tgagaagaca aaccctggcg ctacactaag tatgagacca gcccccattc caatagagga     1140

ccctgaatgg agacaaacgc ctcccccagt ctctgccaca tctggtactt tccgactgcg     1200

acgagggagt cgatttacct ggagaaagga gtgcctggct gttatggaaa gttacttcaa     1260

tgagaatcaa tacccagatg aagcaaagag ggaagaaatt gcaaacgctt gcaatgcagt     1320

tatacagaag ccaggcaaaa agctgtcaga tctggaaaga gttacctccc tgaaagtata     1380

taattggttt gctaacagaa ggaaggagat caagaggaga gccaatattg aagcagcaat     1440

cctggagagt catgggatag atgtgcagag tccaggaggc cactcaaaca gtgatgatgt     1500

cgacgggaat gactactctg agcaggatga cagtacgagc catagtgacc accaagaccc     1560

catctcatta gctgtggaaa tggcagcagt caaccacact atcttggcat tggcccgaca     1620

aggagccaac gaaatcaaga cagaggccct ggatgatgac tgatcaggga ggttaaacat     1680

gacaagttaa cttagtttag acgtagcacc ttagcagact ttcctcggtc cttaacatgt     1740

gttcttacag tataacttgc agtttcttgt atgtcaggta gctgttaggg tcttgttctg     1800

tgaagatggc atggtgccct cagcctttgc atatactctc tcagtattaa ctcccagtaa     1860

ataataacca accaaccaac caaccaaact tccctctccc agcccccgag gctagaaaat     1920

cttgctgctc cgtcttagca ttccaagaaa gtgcttccag gtatttagat agccctcagt     1980

tctcaaatat tagactacgt gtaaaatctt gggtaccttt agattcttgt aacactagtc     2040

tgtactccct tttccttccc caagactgat aggatgcaag ctgaggtcgt ggcacaggaa     2100

tgacagacac catttgggga gtatccacag agtcaaagga acactagaat ccccacctca     2160

gcgtgaggat aattgatttc cagctgcaat aagccgtgcc tcattatagc cacactgtgg     2220

ctagattata cttctttggg tgctgtgcta agaatgtcaa tggaaaaagc cgatctcaga     2280

ttttgtttga agttaacatg cctgacacag acatcctttc ctctcacaag ctgtgtgact     2340

tagtagataa aatactgcct tctgcctttg ggaccatgat taaaaacaaa gacaaaaacc     2400

aaaagtcatt aaaaaaaaaa aaaaaaa                                         2427


<210>  40
<211>  628
<212>  DNA
<213>  Homo sapiens

<400>  40
ggctgcgagg accgtgggca gccagggtcg gtgaaggatc ccaaaatggc tgggcgaaaa       60

cttgctctaa aaaccattga ctgggtagct tttgcagaga tcatacccca gaaccaaaag      120

gccattgcta gttccctgaa atcctggaat gagaccctca cctccaggtt ggctgcttta      180

cctgagaatc caccagctat cgactgggct tactacaagg ccaatgtggc caaggctggc      240

ttggtggatg actttgagaa gaagtttaat gcgctgaagg ttcccgtgcc agaggataaa      300

tatactgccc aggtggatgc cgaagaaaaa gaagatgtga aatcttgtgc tgagtgggtg      360

tctctctcaa aggccaggat tgtagaatat gagaaagaga tggagaagat gaagaactta      420

attccatttg atcagatgac cattgaggac ttgaatgaag ctttcccaga aaccaaatta      480

gacaagaaaa agtatcccta ttggcctcac caaccaattg agaatttata aaattgagtc      540

caggaggaag ctctggccct tgtattacac attctggaca ttaaaaataa taattataca      600

aaaaaaaaaa aaaaaaaaaa aaaaaaaa                                         628


<210>  41
<211>  2534
<212>  DNA
<213>  Homo sapiens

<400>  41
tcgggactcg accgggctgc gctcactgcc cagccggggc cccgggagcc tccaggctcc       60

cgcccgccct gagctgcggc ctccgcatgg aggggccact cactccacca ccgctgcagg      120

gaggcggagc cgccgctgtt ccggagcccg gagcccggca acacccggga cacgagacgg      180

cggcgcagcg gtacagcgcc cgactgctgc aggccggcta cgagcccgag agcatggcgg      240

actacctgat cagcggcggc accggctacg tgcccgagga tgggctcacc gcgcagcagc      300

tcttcgccag cgccgacggc ctcacctaca acgacttcct gattctccca ggattcatag      360

acttcatagc tgatgaggtg gacctgacct cagccctgac ccggaagatc acgctgaaga      420

cgccactgat ctcctccccc atggacactg tgacagaggc tgacatggcc attgccatgg      480

ctctgatggg aggtattggt ttcattcacc acaactgcac cccagagttc caggccaacg      540

aggtgcggaa ggtcaagaag tttgaacagg gcttcatcac ggaccctgtg gtgctgagcc      600

cctcgcacac tgtgggcgat gtgctggagg ccaagatgcg gcatggcttc tctggcatcc      660

ccatcactga gacgggcacc atgggcagca agctggtggg catcgtcacc tcccgagaca      720

tcgactttct tgctgagaag gaccacacca ccctcctcag tgaggtgatg acgccaagga      780

ttgaactggt ggtggctcca gcaggtgtga cgttgaaaga ggcaaatgag atcctgcagc      840

gtagcaagaa agggaagctg cctatcgtca atgattgcga tgagctggtg gccatcatcg      900

cccgcaccga cctgaagaag aaccgagact accctctggc ctccaaggat tcccagaagc      960

agctgctctg tggggcagct gtgggcaccc gtgaggatga caaataccgt ctggacctgc     1020

tcacccaggc gggcgtcgac gtcatagtct tggactcgtc ccaagggaat tcggtgtatc     1080

agatcgccat ggtgcattac atcaaacaga agtaccccca cctccaggtg attgggggga     1140

acgtggtgac agcagcccag gccaagaacc tgattgatgc tggtgtggac gggctgcgcg     1200

tgggcatggg ctgcggctcc atctgcatca cccaggaagt gatggcctgt ggtcggcccc     1260

agggcactgc tgtgtacaag gtggctgagt atgcccggcg ctttggtgtg cccatcatag     1320

ccgatggcgg catccagacc gtgggacacg tggtcaaggc cctggccctt ggagcctcca     1380

cagtgatgat gggctccctg ctggccgcca ctacggaggc ccctggcgag tacttcttct     1440

cagacggggt gcggctcaag aagtaccggg gcatgggctc actggatgcc atggagaaga     1500

gcagcagcag ccagaaacga tacttcagcg agggggataa agtgaagatc gcgcagggtg     1560

tctcgggctc catccaggac aaaggatcca ttcagaagtt cgtgccctac ctcatagcag     1620

gcatccaaca cggctgccag gatatcgggg cccgcagcct gtctgtcctt cggtccatga     1680

tgtactcagg agagctcaag tttgagaagc ggaccatgtc ggcccagatt gagggtggtg     1740

tccatggcct gcactcttac gaaaagcggc tgtactgagg acagcggtgg aggccgaggt     1800

ggtggagggg atgcacccca gtgtccactt ttgggcacag cctccctcca taactgagtg     1860

gtccacagat ttgcactacg ggttctccag ctcctttcca ggcagagagg aggggaggtc     1920

ctgaggggac tgctgcccct cactcggcat cccctgcaga gtcaggactg ctcccggggc     1980

caggctgccc tgggagcccc cctccgagcc cagccagcca ggctctcagg ccctgcgcct     2040

gcctcaggtc tttcttgctg cagcctgctc cagcctggcc cccaccccag gggcaggcgg     2100

cccctcctgg cttctcctgt agggcacctc cctgccccta gcctcccagg aaatggtgct     2160

ctcctggccc tgcctctggc ccttcccggg ccgctgcccc tcagccatgt ggcacttctg     2220

agctcctgac ctaggccaag gggaggtctc tgcccccttc cccggccctg ggctaccctt     2280

gggtcctgct cctcaggccg ctcccctgtc cctggccatg ggtaggagac tgccctggtc     2340

atggccgcct gcctgtcatt cctgactcac caccgtcccc aggtgaacca ttcctccctt     2400

ctcctcagct gcagtcgaag gctttaactt tgcacacttg ggatcacagt tgcgtcattg     2460

tgtattaaat acttggaata aatcaagcag gtctcaacgc ctccactaaa aaaaaaaaaa     2520

aaaaaaaaaa aaaa                                                       2534


<210>  42
<211>  1464
<212>  DNA
<213>  Homo sapiens

<400>  42
agccccaagc ttaccacctg cacccggaga gctgtgtcac catgtgggtc ccggttgtct       60

tcctcaccct gtccgtgacg tggattggtg ctgcacccct catcctgtct cggattgtgg      120

gaggctggga gtgcgagaag cattcccaac cctggcaggt gcttgtggcc tctcgtggca      180

gggcagtctg cggcggtgtt ctggtgcacc cccagtgggt cctcacagct gcccactgca      240

tcaggaacaa aagcgtgatc ttgctgggtc ggcacagcct gtttcatcct gaagacacag      300

gccaggtatt tcaggtcagc cacagcttcc cacacccgct ctacgatatg agcctcctga      360

agaatcgatt cctcaggcca ggtgatgact ccagccacga cctcatgctg ctccgcctgt      420

cagagcctgc cgagctcacg gatgctgtga aggtcatgga cctgcccacc caggagccag      480

cactggggac cacctgctac gcctcaggct ggggcagcat tgaaccagag gagttcttga      540

ccccaaagaa acttcagtgt gtggacctcc atgttatttc caatgacgtg tgtgcgcaag      600

ttcaccctca gaaggtgacc aagttcatgc tgtgtgctgg acgctggaca gggggcaaaa      660

gcacctgctc gggtgattct gggggcccac ttgtctgtaa tggtgtgctt caaggtatca      720

cgtcatgggg cagtgaacca tgtgccctgc ccgaaaggcc ttccctgtac accaaggtgg      780

tgcattaccg gaagtggatc aaggacacca tcgtggccaa cccctgagca cccctatcaa      840

ccccctattg tagtaaactt ggaaccttgg aaatgaccag gccaagactc aagcctcccc      900

agttctactg acctttgtcc ttaggtgtga ggtccagggt tgctaggaaa agaaatcagc      960

agacacaggt gtagaccaga gtgtttctta aatggtgtaa ttttgtcctc tctgtgtcct     1020

ggggaatact ggccatgcct ggagacatat cactcaattt ctctgaggac acagatagga     1080

tggggtgtct gtgttatttg tggggtacag agatgaaaga ggggtgggat ccacactgag     1140

agagtggaga gtgacatgtg ctggacactg tccatgaagc actgagcaga agctggaggc     1200

acaacgcacc agacactcac agcaaggatg gagctgaaaa cataacccac tctgtcctgg     1260

aggcactggg aagcctagag aaggctgtga gccaaggagg gagggtcttc ctttggcatg     1320

ggatggggat gaagtaagga gagggactgg accccctgga agctgattca ctatgggggg     1380

aggtgtattg aagtcctcca gacaaccctc agatttgatg atttcctagt agaactcaca     1440

gaaataaaga gctgttatac tgtg                                            1464


<210>  43
<211>  2597
<212>  DNA
<213>  Homo sapiens

<400>  43
ggagcttcgc tatgcggctg ctttaagatt ctagggttgt acaggcccac gccagacacg       60

acgtctggca ggaacctcgg cctcagagat ggctctgagt aaatcaatgc atgcaagaaa      120

tagatacaag gacaaacctc ctgactttgc atatctggca tccaaatatc cagattttaa      180

gcagcatgtt cagataaatc tgaatggaag agtgagcctt aattttaaag accccgaagc      240

agtcagagct ctgacgtgta ctctcctaag ggaagatttt ggactttcta ttgatattcc      300

attggagaga ctaattccca cagttccctt gagactcaac tatattcact gggtagaaga      360

tctgatcggt caccaggatt ctgacaaaag tactctccga agaggaattg acataggcac      420

gggggcatct tgcatctacc ccttacttgg agcaaccttg aatggctggt atttcctcgc      480

aacagaagtg gatgatatgt gtttcaacta tgcaaagaaa aatgtggaac agaataactt      540

atctgatctc ataaaagtgg tgaaagtgcc acagaagaca ctcctgatgg atgctcttaa      600

agaagaatct gagataatct atgacttttg catgtgcaac cctccctttt ttgccaatca      660

attggaagcc aagggagtaa actcacgaaa tcctcgaaga cctccgccta gttctgttaa      720

tacaggaggc atcacagaga tcatggcaga aggaggtgaa ttagagtttg ttaaaaggat      780

catccatgac agtctacaac ttaaaaaaag attaagatgg tatagctgca tgctgggaaa      840

gaaatgcagc ctggcgcctc tgaaggagga gcttcgcata caaggggttc ccaaagtaac      900

gtacactgaa ttctgtcaag gtcggacaat gagatgggcc ttagcttgga gtttttatga      960

tgatgtcaca gtaccatcac caccaagtaa gcgaagaaaa ttagagaaac cgagaaaacc     1020

cataacattc gtggtgctgg cgtccgtgat gaaggaatta tccctcaaag catcacctct     1080

gcgctcggag acggcggaag gcatagtcgt tgtcacgaca tggattgaaa aaattctcac     1140

tgatttgaag gtccagcata aacgagttcc ctgtggaaaa gaggaagtca gccttttcct     1200

aacggccata gaaaactcct ggattcattt aaggagaaag aaaagagagc gtgtgagaca     1260

gctgagagaa gttccccgag ctcctgagga cgtcattcag gccttggaag agaaaaagcc     1320

cacccccaaa gagtctggca atagccaaga actggccagg ggcccccagg agaggacccc     1380

ctgtgggcct gctctgcggg aaggcgaggc tgccgctgtg gagggcccgt gcccgagcca     1440

ggagtccctg tcccaggagg aaaacccgga acccacggag gatgaaagga gtgaggaaaa     1500

gggaggggtg gaggttttgg aaaattgtca aggctctagc aacggagccc aggaccaaga     1560

ggcttctgag cagttcggca gcccagtggc tgaaaggggg aaacgtctcc caggagtggc     1620

cggacagtac ctgtttaagt gtttgataaa cgttaagaag gaggtggacg atgccttagt     1680

ggagatgcac tgggttgagg gccagaacag ggatctgatg aaccagcttt gcacctacat     1740

acgtaaccaa attttcaggc ttgttgcagt taactagaaa cctcctgcac agttggaaac     1800

gtgttgatag taacttgctt tggagtggcc tgtggggtgg caagaggaat cctaccagcg     1860

gcccattagt agcacgatgt ggaattatct tcgaaaacaa aaacctatga atctgtcccc     1920

cacctccccc cgcctccttc ccgctttttg agttacaggg agtcgtagtg tggtcattta     1980

caaggaggaa ttgtggtcat cagtaacaac agaaagccct cagtaaactc ccgagggatt     2040

gcaagctggc tcaagctggc ccctcagctc tggactgcct ctgcaaggtc agaagggttg     2100

tttgtggagt ctgggctggg cagcactgcc tagaatatca tgctgtctct gtcacccaag     2160

ggtgtttctt gaggaggggt ggctctctct gcctccagct ggaggccctg gtaccctgtt     2220

ctaggtcact cttcaagatg gggcctacct tgcatcaatc ccacaaaggg agctgtatgg     2280

tgggtggtgg ggaatctggg agagaaacct tagtaatgct gggaaggagc agcagagtct     2340

ggggaccacc cggtaaatgg cacattcctg acacctggct gttttgatgt tgcttatttc     2400

agaagcagaa ttaggtaagc aaaactcccc ggtgtgactg aggcacacag aaggcaccca     2460

tacccccacc tccagcctgt tgacagtacc attttgtagc agttttacta ctgtgtgatt     2520

tttgtttgga catctgaagt agagcttgtt ttgtttttaa ataagaatat tcacaaatta     2580

aaaaaaaaaa aaaaaaa                                                    2597


<210>  44
<211>  2107
<212>  DNA
<213>  Homo sapiens

<400>  44
atggacgcgg cactgctcca cagcctgctg gaggccaact gcagcctggc gctggctgaa       60

gagctgctct tggacggctg ggggccaccc ctggaccccg agggtcccta ctcctactgc      120

aacacgacct tggaccagat cggaacgtgc tggccccgca gcgctgccgg agccctcgtg      180

gagaggccgt gccccgagta cttcaacggc gtcaagtaca acacgacccg gaatgcctat      240

cgagaatgct tggagaatgg gacgtgggcc tcaaagatca actactcaca gtgtgagccc      300

attttggatg acaagcagag gaagtatgac ctgcactacc gcatcgccct tgtcgtcaac      360

tacctgggcc actgcgtatc tgtggcagcc ctggtggccg ccttcctgct tttcctggcc      420

ctgcggagca ttcgctgtct gcggaatgtg attcactgga acctcatcac cacctttatc      480

ctgcgaaatg tcatgtggtt cctgctgcag ctcgttgacc atgaagtgca cgagagcaat      540

gaggtctggt gccgctgcat caccaccatc ttcaactact tcgtggtgac caacttcttc      600

tggatgtttg tggaaggctg ctacctgcac acggccattg tcatgaccta ctccactgag      660

cgcctgcgca agtgcctctt cctcttcatc ggatggtgca tccccttccc catcatcgtc      720

gcctgggcca tcggcaagct ctactatgag aatgaacagt gctggtttgg caaggagcct      780

ggcgacctgg tggactacat ctaccaaggc cccatcattc tcgtgctcct gatcaatttc      840

gtatttctgt tcaacatcgt caggatccta atgacaaagt tacgcgcgtc caccacatcc      900

gagacaatcc agtacaggaa ggcagtgaag gccaccctgg tgctcctgcc cctcctgggc      960

atcacctaca tgctcttctt cgtcaatccc ggggaggacg acctgtcaca gatcatgttc     1020

atctatttca actccttcct gcagtcgttc cagggtttct tcgtgtctgt cttctactgc     1080

ttcttcaatg gagaggtgcg ctcagccgtg aggaagaggt ggcaccgctg gcaggaccat     1140

cactcccttc gagtccccat ggcccgggcc atgtccatcc ctacatcacc cacacggatc     1200

agcttccaca gcatcaagca gacggccgct gtgtgacccc tcggtcgccc acctgcacag     1260

ctcccctgtc ctcctccacc ttcttcctct gggttctctg tgctgggcag gctctcgtgg     1320

ggcaggagat gggaggggag agaccagctc tccagcctgg caggaaagag ggggtgcggc     1380

agccaagggg gactgcaagg gacagggatg agtgggggcc accaggctca gcgcaagagg     1440

aagcagaggg aattcacagg accccctgag aagagccagt cagatgtctg caggcatttg     1500

cccatcccag cctctctggc cagggcctta ctgggcccag agcagagaag gacctgtcca     1560

acacacacag ctatttatag tagcagacac agggctcccc tgccctactc atggagccag     1620

cagccaggca atggtgtggc cctgcactgg cccttggact ccacactcag tggtgccctg     1680

cagttgggtg ggttacgcca gcaaaggatc agtttggctg ccttatccca gggctgtcac     1740

ctagagaggc tcacttgtac cccaccctgt tcctgtgtcc cctccccagc catcctcccg     1800

ccttgggggc tccatgaagg atgcaggctt ccaggcctgg cttcctctct tgggagaccc     1860

cttctctgcc tagtccacag attaggcaat caaggaagac gccatcaggg aagccacatc     1920

cttagtcaac cagttgcatc gtgcggggca aaatgaggag cagaggcatg gaggagggag     1980

gcgtgggatg ggaatagcag aaccaccatg tcttcagtga ttgaaactca taccccattg     2040

ccctttgccc tccagtctcc ccttcagaaa catctctgct ctctgtgaaa taaaccatgc     2100

ctcttgg                                                               2107


<210>  45
<211>  1123
<212>  DNA
<213>  Homo sapiens

<400>  45
cgcggtcgcg agccatggag gaggaggcat cgtccccggg gctgggctgc agcaagccgc       60

acctggagaa gctgaccctg ggcatcacgc gcatcctaga atcttcccca ggtgtgactg      120

aggtgaccat catagaaaag cctcctgctg aacgtcatat gatttcttcc tgggaacaaa      180

agaataactg tgtgatgcct gaagatgtga agaactttta cctgatgacc aatggcttcc      240

acatgacatg gagtgtgaag ctggatgagc acatcattcc actgggaagc atggcaatta      300

acagcatctc aaaactgact cagctcaccc agtcttccat gtattcactt cctaatgcac      360

ccactctggc agacctggag gacgatacac atgaagccag tgatgatcag ccagagaagc      420

ctcactttga ctctcgcagt gtgatatttg agctggattc atgcaatggc agtgggaaag      480

tttgccttgt ctacaaaagt gggaaaccag cattagcaga agacactgag atctggttcc      540

tggacagagc gttatactgg cattttctca cagacacctt tactgcctat taccgcctgc      600

tcatcaccca cctgggcctg ccccagtggc aatatgcctt caccagctat ggcattagcc      660

cacaggccaa ggtaagggag gaacacctgc cattgtaaac tatggtatat tccaaaatct      720

actgaggaaa tggttacatt gcaggttccc aacttcccta tctgattcag gagatctagg      780

gtggggccca ggaacctgca ttttcaataa gcaagacaga tgattccaat ggacagcctc      840

actttactca tctagttaag tggttcccaa acttgactga ttctcagaat taactgggga      900

gttttatttt taatgaaatt ctgttggata gtttatgtcc catgacttgt tctgggttgg      960

cagtacatgc acccaggaag agtgaaaagt cagattctca ctcccctgtt ctccaagtgt     1020

gcatccccag tggcagctgc tattacgagt ttcctgtacg cccttcccaa gatactcatt     1080

gcacataaag catgcatgca caaaaaaaaa aaaaaaaaaa aaa                       1123


<210>  46
<211>  4538
<212>  DNA
<213>  Homo sapiens

<400>  46
tggtgtgggg agacgctggt cctccccgtc ctcccatagc gcttattgcc tcaccctcac       60

cccctagggg ccggatccaa aggcgctgca ctccccaagc cttggggcat cagccaggaa      120

ggtttcctac ctcctaattc aggggcagga ctcctctttt ccccccacgg ggaaaagagg      180

cagaaactta ggggtttccc tcctttctta gggtcagacg ctcttagggt ccacttcttc      240

aggggcggaa gcctctccta cccttcccat aggggcacag gcctttaccc cactgtactt      300

cggagccaac gcctttccct cagcactgcc accccagagt caggacccag aggactgtgc      360

cttcgccccc aacgcaggcg cggccttttg gagaggaggg aggagtggag aggacagggg      420

cccttgctct cccctcccca acttgttcct cttgcccccc agtccctggc aatccagaga      480

tcccgatatc taggactgtc catccatcca ctccctgacc ttttcccggc tcctggctgc      540

agccatggag ttgcagaagg gaaaaggggc ggcagcagca gcagctgctt cgggagcagc      600

gggaggtgga ggaggaggag cgggagcagg agccccagga ggggggaggc tgctactttc      660

aaccagtttg gatgccaagg atgagttaga ggagagattg gaaaggtgta tgagcattgt      720

gacatcgatg actgctggtg tctcggagag agaagccaat gatgccctca atgcgtatgt      780

gtgcaaaggc ctcccccagc atgaagaaat ctgcctgggc ctgtttactc tcatcctcac      840

tgaacctgcc caagcccaga agtgttaccg ggacttagct ctggtgagtc gtgatggcat      900

gaatattgtc ctgaataaaa tcaaccagat acttatggag aagtacctga agctgcagga      960

tacctgccgt actcagttgg tgtggttggt acgggaactg gtgaagagtg gggttctggg     1020

agccgatggt gtttgtatga cgtttatgaa gcagattgca ggtggagatg ttacagccaa     1080

aaatatctgg ttggcagaaa gtgttctgga tatcctgaca gagcaaaggg agtgggtcct     1140

gaagagcagc atcctcattg ccatggctgt ttacacgtac ctccgcctca tcgtggacca     1200

ccatgggact gcccagctcc aggccctgcg acagaaggaa gtagacttct gcatctcact     1260

gcttcgggaa cggttcatgg aatgtctgat gattggtcgg gatctcgtaa gactacttca     1320

gaatgttgct aggataccag aatttgaact gctttggaaa gatattatcc ataatcctca     1380

ggccttgagt cctcagttca caggtatcct acagcttctt cagtcaagaa catcccgaaa     1440

attcctagca tgtcgtctaa ccccggacat ggagactaaa ctcctcttca tgacatcccg     1500

ggtgcgattt ggtcaacaaa agcgatacca agattggttc cagcgccagt acctgtcaac     1560

tccagatagt cagtctctgc gctgtgacct cattcgctac atctgtgggg tagtccaccc     1620

ttctaatgaa gtactgagtt cagatatctt gccccggtgg gccatcattg gttggctcct     1680

gacaacgtgc acgtcaaatg tcgctgcctc caatgccaag ctggctttgt tttatgactg     1740

gctgttcttt agtccagaca aggatagcat tatgaacata gaaccagcca tcctggtcat     1800

gcaccactcc atgaagcccc acccagccat cactgccaca ctcctggact tcatgtgccg     1860

catcattccc aacttctatc caccattgga gggccacgtg cggcagggtg tcttttcctc     1920

cctcaaccac attgtggaga aacgggtctt ggcacaccta gctcccctgt ttgacaaccc     1980

taagttggat aaggagctgc gggcaatgct gagagagaag tttcctgagt tctgcagctc     2040

accctcccca cctgtggaag tcaaaattga ggagccagtt tccatggaga tggacaacca     2100

tatgtcggat aaggatgaga gttgctatga caatgcagag gcagccttca gtgacgatga     2160

agaggatctc aacagcaaag gaaagaagag ggagtttcgc ttccacccta tcaaggagac     2220

agttgtggag gagccagttg atatcacccc ttaccttgac cagttggatg agtccctgag     2280

ggacaaagta ctccagctac agaaggggag tgatacggag gcccagtgtg aggtcatgca     2340

ggaaattgtg gaccaggtcc tggaggaaga ctttgactcg gagcagctgt ctgtccttgc     2400

ttcctgccta caggagctct tcaaggccca ctttcgaggg gaggtcctgc ctgaggagat     2460

tactgaggag tccctggagg agtctgtagg aaagcctctg tacctaatat ttaggaacct     2520

atgtcagatg caggaagaca acagcagctt ctctctactt ctagaccttc tctccgagct     2580

atatcagaag cagcccaaga ttggctacca cctgctctac tacctgaggg ccagcaaagc     2640

cgccgcaggg aagatgaacc tgtacgagtc atttgcccag gctacccagc tgggcgatct     2700

gcacacctgc ctgatgatgg acatgaaggc ctgccaggag gacgatgtgc ggctcctgtg     2760

ccacctcacg ccctccatct acacagagtt tccagatgaa accttgagga gcggagagct     2820

gctgaacatg atcgtggctg ttattgactc tgcacagctc caggagctgg tctgccacgt     2880

gatgatgggt aacctggtta tgtttcgaaa agactcagtt ctcaacatac tcattcagag     2940

cctagactgg gagacctttg agcagtattg tgcctggcag ctctttctgg cccacaatat     3000

tcccctggag accataatcc ccatcctgca gcacctcaaa tacaaggagc acccagaggc     3060

cctgtcctgc ctactgcttc aactccgaag agaaaagccc agcgaggaga tggtgaagat     3120

ggtgctgagc cggccctgcc atcctgacga ccagttcacc accagcatcc tgcggcactg     3180

gtgcatgaaa catgacgagc tgctggccga gcacatcaag tccctgctca tcaagaacaa     3240

cagcctgcct cgcaagagac agagcctgag gagctctagc agcaagctgg cccagctgac     3300

tctggagcag atcctggagc acttggacaa tctgcggctc aacctgacca acaccaagca     3360

gaactttttt agccagacgc caattctcca ggcgctgcag catgtccaag cgagctgtga     3420

cgaagcccac aagatgaaat tcagtgatct cttctccctg gcggaggaat atgaggactc     3480

ttccaccaag ccacccaaga gccggcgaaa agcagctctg tccagccctc gaagtcgaaa     3540

gaatgccaca cagcccccca atgccgaaga agagtcgggc tccagcagtg cttcagaaga     3600

ggaagacacg aaaccgaagc ctaccaagcg gaaacgaaaa gggtcctctg cagtgggctc     3660

tgacagtgac tgaggccctg cattccccat cccacccccg gctggactgc cctctccttc     3720

ttggtgattc aaaggttaat agaggctgag gagattgcag gggaaacacc cttgctgcat     3780

ccccaagctc ccccggtgga aggaggagct ttctcctctg gctgagtttg agaagctgcc     3840

atgcagcccc tagccccttc cctcctcctg gggcctccag cccctcacac tgctgttccc     3900

agtgatattt gggatctgac tgaagccaga ggctctgtaa aatcagacca tagtggaagt     3960

cctcagcccc ctggcccctt ccgcaatctc ctcccccagt ctcccaaaga gccatttcaa     4020

cagagaaggg aaatgacaaa ggggcagctg gccagataag ctaggatgag agcagagact     4080

cagtgtgtgg gtgtcccttc ctgcttcccc ttcaggtctt ggtttgttct gaagggacgt     4140

tttatagtca ctatccacat gccagtgtga aatgggcatc tatgacgtgg tcagggtgtc     4200

cattcctaat catggggcag atgccacaag cattcagaaa ggagtctgaa agggtggcca     4260

cagccccacg tggtgtgccc tggaggctta ggttggtctg aggttggcac ctcaatctac     4320

accagagccc agggagtccc agaggcaagt ttcacagaat tgtcaaatga tcccatttcc     4380

ttgagtctgt tttttttttt gttttttttt gttttttttt tggcagagat aatcgtgtct     4440

taaaagttgt ttttaaatga caataaaaca agccagaatg tcaaaaaaaa aaaaaaaaaa     4500

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaa                             4538


<210>  47
<211>  1937
<212>  DNA
<213>  Homo sapiens

<400>  47
ggccgcagtt tctggaggga gccgctgcgg gtctttccct cactcgtcct ccgcgcgtcg       60

ccgctcttcg gttctgctct gtccgccgcc atggcccaag ctgacatcgc gctgatcgga      120

ttggccgtca tgggccagaa cttaattctg aacatgaatg accacggctt tgtggtctgt      180

gcttttaata ggactgtctc caaagttgat gatttcttgg ccaatgaggc aaagggaacc      240

aaagtggtgg gtgcccagtc cctgaaagag atggtctcca agctgaagaa gccccggcgg      300

atcatcctcc tggtgaaggc tgggcaagct gtggatgatt tcatcgagaa attggtacca      360

ttgttggata ctggtgacat catcattgac ggaggaaatt ctgaatatag ggacaccaca      420

agacggtgcc gagacctcaa ggccaaggga attttatttg tggggagcgg agtcagtggt      480

ggagaggaag gggcccggta tggcccatcg ctcatgccag gagggaacaa agaagcgtgg      540

ccccacatca agaccatctt ccaaggcatt gctgcaaaag tgggaactgg agaaccctgc      600

tgtgactggg tgggagatga gggagcaggc cacttcgtga agatggtgca caacgggata      660

gagtatgggg acatgcagct gatctgtgag gcataccacc tgatgaaaga cgtgctgggc      720

atggcgcagg acgagatggc ccaggccttt gaggattgga ataagacaga gctagactca      780

ttcctgattg aaatcacagc caatattctc aagttccaag acaccgatgg caaacacctg      840

ctgccaaaga tcagggacag cgcggggcag aagggcacag ggaagtggac cgccatctcc      900

gccctggaat acggcgtacc cgtcaccctc attggagaag ctgtctttgc tcggtgctta      960

tcatctctga aggatgagag aattcaagct agcaaaaagc tgaagggtcc ccagaagttc     1020

cagtttgatg gtgataagaa atcattcctg gaggacattc ggaaggcact ctacgcttcc     1080

aagatcatct cttacgctca aggctttatg ctgctaaggc aggcagccac cgagtttggc     1140

tggactctca attatggtgg catcgccctg atgtggagag ggggctgcat cattagaagt     1200

gtattcctag gaaagataaa ggatgcattt gatcgaaacc cggaacttca gaacctccta     1260

ctggacgact tctttaagtc agctgttgaa aactgccagg actcctggcg gcgggcagtc     1320

agcactgggg tccaggctgg cattcccatg ccctgtttta ccactgccct ctccttctat     1380

gacgggtaca gacatgagat gcttccagcc agcctcatcc aggctcagcg ggattacttc     1440

ggggctcaca cctatgaact cttggccaaa ccagggcagt ttatccacac caactggaca     1500

ggccatggtg gcaccgtgtc atcctcgtca tacaatgcct gatcatgctg ctcctgtcac     1560

cctccacgat tccacagacc aggacattcc atgtgcctca tggcactgcc acctggccct     1620

ttgccctatt ttctgttcag ttttttaaaa gtgttgtaag agactcctga ggaagacaca     1680

cagtttattt gtaaagtagc tctgtgagag ccaccatgcc ctctgccctt gcctcttggg     1740

actgaccagg agctgctcat gtgcgtgaga gtgggaacca tctccttgcg gcagtggctt     1800

ccgcgtgccc cgtgtgctgg tgcggttccc atcacgcaga caggaagggt gtttgcgcac     1860

tctgatcaac tggaacctct gtatcatgcg gctgaattcc ctttttcctt tactcaataa     1920

aagctacatc acactga                                                    1937


<210>  48
<211>  4390
<212>  DNA
<213>  Homo sapiens

<400>  48
tatcctatcc ctatcctagc ttttaacctg agccagagct cactacacag gttcctggct       60

atcgagtctg aatctgcact actcaactta taaactgtct gcagacacct gttagggaaa      120

ttgctgatca tgggcggcag gatctgaact cgctttacct tcttgtttgg agcacaggga      180

ccgcccagct agaggagcac cagcgcactg cgccccagcc ctgggcgagg gtgcggagga      240

tttgttctcg gtgcaatcct gctggcgctt ttccggggtt ctgcgcggat ccagctcccc      300

atctctgctc ctacacacac aaaagaaaac aactctcgat tggaagttgt ggaattttct      360

cagcccctac gaggcgcggg gattctccag ccccggccct cctcccgcca gcctgaggtc      420

tccttcgctc gcctgccttg ctagggaccg cagtccctca gccgcagctg ggtctgtccg      480

ccccgccttt gccctcgcct tttcccgggg cggatttggt gaagtcggcc tcaagtccag      540

gaggtctgtc ttcgccgggc cagctctcgc ggaactgggg ggtagagagc aaagggagag      600

attcgtggaa gggaagggag gtaggggtgg cgcaaacgcc cagagtatca aacttggggg      660

tggcacagta ggtgacagca gcagctgcag gtggtggctg gggacccgcg agggggcgcc      720

cctctgggta gggtctggct gagcgggctt gcaagcccgg gaggcggctg agagaccctg      780

gacactgttc ctgctccctc gccaccaaaa cttctcctcc agtcccctcc cctgcaggac      840

catcgcccgc agcctctgca cctgttttct tgtgtttaag ggtggggttt gcccccctcc      900

ccacgctccc atctctgatc ctcccacctt cacccgccca ccccgcgagt gagtgcggtg      960

cccaggcgcg cttggcctga gaggtcggca gcagacccgg cagcgccaac cgcccagccg     1020

ctctgactgc tccggctgcc cgcccgcgcg gcgcgggctg tcctggaccc taggagggga     1080

cggaaccgga cttgcctttg ggcaccttcc agggccctct ccaggtcggc tggctaatca     1140

tcggacagac ggactgcaca catcttgttt ccgcgtctcc gcaaaaacgc gaggtccagg     1200

tcagttgtag actcttgtgc tggttgcagg ccaagtggac ctgtactgaa aatgggtcca     1260

ataggtgcag aggctgatga gaaccagaca gtggaagaaa tgaaggtgga acaatacggg     1320

ccacaaacaa ctcctagagg tgaactggtc cctgaccctg agccagagct tatagatagt     1380

accaagctga ttgaggtaca agttgttctc atattggcct actgctccat catcttgctt     1440

ggggtaattg gcaactcctt ggtgatccat gtggtgatca aattcaagag catgcgcaca     1500

gtaaccaact ttttcattgc caatctggct gtggcagatc ttttggtgaa cactctgtgt     1560

ctaccgttca ctcttaccta taccttaatg ggggagtgga aaatgggtcc tgtcctgtgc     1620

cacctggtgc cctatgccca gggcctggca gtacaagtat ccacaatcac cttgacagta     1680

attgccctgg accggcacag gtgcatcgtc taccacctag agagcaagat ctccaagcga     1740

atcagcttcc tgattattgg cttggcctgg ggcatcagtg ccctgctggc aagtcccctg     1800

gccatcttcc gggagtattc gctgattgag atcatcccgg actttgagat tgtggcctgt     1860

actgaaaagt ggcctggcga ggagaagagc atctatggca ctgtctatag tctttcttcc     1920

ttgttgatct tgtatgtttt gcctctgggc attatatcat tttcctacac tcgcatttgg     1980

agtaaattga agaaccatgt cagtcctgga gctgcaaatg accactacca tcagcgaagg     2040

caaaaaacca ccaaaatgct ggtgtgtgtg gtggtggtgt ttgcggtcag ctggctgcct     2100

ctccatgcct tccagcttgc cgttgacatt gacagccagg tcctggacct gaaggagtac     2160

aaactcatct tcacagtgtt ccacatcatc gccatgtgct ccacttttgc caatcccctt     2220

ctctatggct ggatgaacag caactacaga aaggctttcc tctcggcctt ccgctgtgag     2280

cagcggttgg atgccattca ctctgaggtg tccgtgacat tcaaggctaa aaagaacctg     2340

gaggtcagaa agaacagtgg ccccaatgac tctttcacag aggctaccaa tgtctaagga     2400

agctgtggtg tgaaaatgta tggatgaatt ctgaccagag ctatgaatct ggttgatggc     2460

ggctcacaag tgaaaactga tttcccattt taaagaagaa gtggatctaa atggaagcat     2520

ctgctgttta attcctggaa aactggctgg gcagagcctg tgtgaaaata ctggaattca     2580

aagataaggc aacaaaatgg tttacttaac agttggttgg gtagtaggtt gcattatgag     2640

taaaagcaga gagaagtact tttgattatt ttcctggagt gaagaaaact tgaacaagaa     2700

attggtatta tcaaagcatt gctgagagac ggtgggaaaa taagttgact ttcaaatcac     2760

gttaggacct ggattgagga ggtgtgcagt tcgctgctcc ctgcttggct tatgaaaaca     2820

ccactgaaca gaaatttctc cagggagcca caggctctcc ttcatcgcat tttgattttt     2880

ttgttcattc tctagacaaa atccatcagg gaatgctgca ggaaacgatt gccaactata     2940

cgaatggctt cgaggagata aactgaaatt tgctatataa ttaatatttt ggcagatgat     3000

aggggaactc ctcaacactc agtgggccaa ttgttcttaa aaccaattgc acgtttggtg     3060

aaagtttctt caactctgaa tcaaaagctg aaattctcag aattacagga aatgcaaacc     3120

atcatttaat ttctaatttc aagttacatc cgctttatgg agatactatt tagataacaa     3180

gaatacaact tgatactttt attgttatac ctttttgaac atgtatgatt tctgttgtta     3240

tttacctttt taaacagata aatatttttt tttcatttta gagtagcgga atctaatctt     3300

aatctaatct tttaggagta tatttcagag aaattccaag cacaccagta tgaccatcct     3360

tatttcagaa atgacaatgc atagaggaaa agtaatatgt gcaaagcctc cgaagaggat     3420

ggttaagtaa agacttaggt taccagtatc aggctttcgt ttttgtatgt aggtagctct     3480

actgcctcct cttaaaacca acaaaggaaa gagagactgg ctgcaaactt ttagaaggaa     3540

tggcttcgaa tagggttcct gggaggaatc ccgaggaaat agacgctgct gctctgctga     3600

ttgtctccac tatcctgttt tgctcctacc cactaatcca gcctgggagg ctctgggcat     3660

tagcggaagg cttcaccaca aggagacagg agcgagtatt ccataggcat gcgctcctag     3720

tggcacgagt ggcttgggtc aggatcaaag agtgaaggat tcggaagtca gctatctgga     3780

gagagagaga gattgtgttt tattcgtgtc ccatagcttt cctatcctat ccctatccta     3840

gcttttaacc tgagccagag ctcactacac aggttcctgg ctatcgagtc tgaatctgca     3900

ctactcaact tataaactgt ctgcagacac ctgttaggga aattgctgat catgggcggc     3960

aggatctgaa ctcgctttac cttcttgttt ggagcacagg gaccgcccag ctagaggagc     4020

accagcgcac tgcgccccag ccctgggcga gggtgcggag gatttgttct cggtgcaatc     4080

ctgctggcgc ttttccgggg ttctgcgcgg atccagctcc ccatctctgc tcctacacac     4140

acaaaagaaa acaactctcg attggaagtt gtggaatttt ctcagcccct acgaggcgcg     4200

gggattctcc agccccggcc ctcctcccgc cagcctgagg tctccttcgc tcgcctgcct     4260

tgctagggac cgcagtccct cagccgcagc tgggtctgtc cgccccgcct ttgccctcgc     4320

cttttcccgg ggcggatttg gtgaagtcgg cctcaagtcc aggaggtctg tcttcgccgg     4380

gccagctctc                                                            4390


<210>  49
<211>  1808
<212>  DNA
<213>  Homo sapiens

<400>  49
ataaaaagaa tggctttgca ctgagcagct cagtctactg gtctcatcag tgaaaggctt       60

gtgaaaattt ctggaaagag cattggctgg cttgttcatc tctctgtttg gtcagttgct      120

gtgtttctgc cggatcagat gagcagattg gttagtgaag gtcagtgtga gaagaagatt      180

gtttctgagc ttgagaagct tctggaggat tgaagagtat ttgaagtctg tgtcaaacat      240

ccacatcata agtggaattt tggagatatt caaagaatgc tgtcagaagg gtatctcagt      300

ggacttgagt actggaatga catccactgg agttgtgcct cttataatga gcaggtggct      360

ggggaaaagg aagaggagac aaattctgtt gctacccttt cctattcctc tgtggatgaa      420

acacaagtca gaagtctcta cgtgagctgc aaatcatctg gcaagtttat ctcttcagtg      480

cattcaagag agagccaaca tagcagaagt cagagagtca cagtgctgca gacaaacccc      540

aatcctgtgt ttgaaagccc aaacttggct gcagttgaaa tatgtagaga tgccagcaga      600

gagacctact tggttccatc ttcttgcaaa agtatttgca agaactataa tgacttacag      660

attgcagggg gccaggtgat ggccattaat tcagtgacaa cagattttcc ctctgagagc      720

agttttgaat atggcccttt gctgaagtca tctgagattc ctttacccat ggaggattcc      780

atttctactc agcccagtga ctttccccaa aaacctatcc agcggtactc atcctattgg      840

agaataacaa gcatcaaaga gaaaagcagc ttgcaaatgc agaatcctat ttctaatgca      900

gtgctgaatg agtacctgga gcagaaggtt gtggagttat ataaacagta cattatggac      960

accgtgtttc atgacagttc tcctacccag attctggcgt ctgaactcat catgacaagt     1020

gtagaccaaa tcagtcttca agtgtctaga gagaagaatc tggagacctc aaaagccaga     1080

gatatagtct ttagccgcct attgcaattg atgtcaactg aaattactga aattagcact     1140

cctagtctcc atatttctca gtatagcaat gtaaatccat agagaggatg cttccattac     1200

tgtctcgcat ttacttaaac atgaagcaac actttatcca tttattctga gaatgtgcag     1260

gaggggttag tgaaggggaa ttaagggcta gagaagtaaa gatcagctgg aagtcatgtg     1320

tgaatcatgg agaaatctca taatattaca cttgatgaag gaatatggta agaggagcca     1380

taaggaatga tttcaaagag aggtgtgtac agcaaggaag caaaaataaa aatgatcaaa     1440

aaagaaacgg ttaattcatt tgaagaaaca taggaattaa aaaagaagac agtcaaatga     1500

gatgaaacaa aaaggccaaa aggtagccgg gtgtagtggc tcacgcctgt aatcccagca     1560

tttgggaggc tgatgtgggt ggattacctg acgtcaggaa ttcgagaccg gcctggccaa     1620

tatggtgaaa ccccatctct actaaaaata caaaaaatta gctggacatg gtggtgggta     1680

cctgtaatcc cagctactag ggaggctgag gcaggagaat ctcttgaacc tgagaggcag     1740

aggttgcagt gagccgaggt cgctccattg cactccagcc tgggcaacaa gagtgagact     1800

cccgtctc                                                              1808


<210>  50
<211>  1628
<212>  DNA
<213>  Homo sapiens

<400>  50
gtggcagcgg ctggcggcaa aacctctcga gtgagcccct gcccgagtgc cgcgggggag       60

aggccgcgag cgggaccgag aagtgggctg ggagcagagg tcgcggaggt ggcgagcgag      120

gccggggccc aggcggggac cggcaggggc ccgggagtgg cgggcacgcc agggtcaggg      180

tgccgggcga gggagggggc ccggggttgg ggaagggggc ccggggaggg aggtaaacag      240

ccctgcaggc ctcggggcac cgttgctggg cggcgccggc ggcatgtgcg agggcccgtc      300

ccgcatctcg gggcccatcc ccccagaccc gacgctctgt cctgacaact acaggcggcc      360

gacctcggct caagggcgcc tcgagggaaa cgcgctgaag ctggacttgc tgacttccga      420

ccgggccctg gacaccaccg ctccccgtgg cccctgcatc ggtcccggtg ccggagagat      480

cctggagcgc ggccagcgcg gcgtcgggga cgtgctgttg caactcgagg ggatctccct      540

aggtcctggg gcctctctca agaggaagga ccctaaggac catgagaagg agaacctgag      600

gcggatcagg gagattcaga agcgcttcag agaacaggag cgcagccggg agcagggcca      660

gcccaggccc ctgaaagctc tgtggcgctc acccaagtac gacaaggtgg agtcccgggt      720

caaggcccag ctccaggagc ctggccctgc ctctgggaca gagtctgccc acttcctgcg      780

ggcgcactcc cgctgcggcc ctggcctccc accaccccat gtatctagtc cccagccaac      840

cccaccaggt cccgaagcta aggagccagg cctgggggtg gacttcattc gtcacaatgc      900

acgagctgcc aagagagccc cccggaggca ttcctgctca ctgcaggtcc tggcacaagt      960

gctagagcag cagcggcagg cccaggagca ctacaatgcc acgcagaagg gccatgtgcc     1020

acattacttg ttggagcgca gggacctgtg gcggcgggag gccgaggccc gcaagcagag     1080

ccagccggac cctgccatgc ccccaggcca cacgcgcatg cctgagaacc agcggctgga     1140

aacactgacc aagctgctcc agagccagag ccagctgctg cgtgagctgg tactgctgcc     1200

tgctggggca gactcactga gagcccagag ccaccgtgct gagctggacc ggaagctggt     1260

gcaggtagag gaggccatca agatcttttc tcggcccaaa gtcttcgtga agatggacga     1320

ctgagcccct ttgggggaca gtggcaagga gctccatgct gaggatcgcc acatggctgc     1380

aaaggacagg gttggaccca atcccagagc agaggtctga agacaggagc aggggggtgg     1440

ccagtgtccc tagagcactc ttcccagtca ccagtggctg cagaagggcc accctagcct     1500

tttaactgct ttgtcaaaat taaacatttt gtacacagaa aaaaaaaaaa aaaaaaaaaa     1560

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa     1620

aaaaaaaa                                                              1628


<210>  51
<211>  3546
<212>  DNA
<213>  Homo sapiens

<400>  51
gtcacttccg gcagccggag gcagcagagg aagccgaggg gcggccatct tggctccgtg       60

aggctctgag gtgccggggt gcggcggcgg cagcggcggc cagcagggcg gaggctgagg      120

cagcaagctc gctagagagg gagaagcagt cgggcgcagg cgcctcctcc gcagcccgct      180

ccatggtcgg cgcccacagc ccgcggcggc ctgtcttgcg ctccacttcc ttcacatcct      240

cctccgcctc ctcgttttca ggcgccgccg gcggcgctgt gtggaggccc gcgagctgaa      300

attcgcggtg cgacgggagg gagtggagaa ggaggtgagg gggcccagga tcgcggggcg      360

ccctgaggca aggggacgcc ggcgggccga agcgcagccc gccgcccgca ggctcggctc      420

cgccactgcc gccctcccgg tctcctcgcc tcggccgccg aggcagggag agaatgagcc      480

ccgggacccg ccgggggacg gcccgggcca ggcccgggat ctagacggcc gtagggggaa      540

gggagccgcc ctccccacgg cgccttttcg gaactgccgt ggactcgagg acgctggtcg      600

ccggcctcct agggctgtgc tgttttgttt tgaccctcgc attgtgcaga attaaagtgc      660

agtaaaatgt ccactaggac cccattgcca acggtgaatg aacgagacac tgaaaaccac      720

acgtcacatg gagatgggcg tcaagaagtt acctctcgta ccagccgctc aggagctcgg      780

tgtagaaact ctatagcctc ctgtgcagat gaacaacctc acatcggaaa ctacagactg      840

ttgaaaacaa tcggcaaggg gaattttgca aaagtaaaat tggcaagaca tatccttaca      900

ggcagagagg ttgcaataaa aataattgac aaaactcagt tgaatccaac aagtctacaa      960

aagctcttca gagaagtaag aataatgaag attttaaatc atcccaatat agtgaagtta     1020

ttcgaagtca ttgaaactga aaaaacactc tacctaatca tggaatatgc aagtggaggt     1080

gaagtatttg actatttggt tgcacatggc aggatgaagg aaaaagaagc aagatctaaa     1140

tttagacaga ttgtgtctgc agttcaatac tgccatcaga aacggatcgt acatcgagac     1200

ctcaaggctg aaaatctatt gttagatgcc gatatgaaca ttaaaatagc agatttcggt     1260

tttagcaatg aatttactgt tggcggtaaa ctcgacacgt tttgtggcag tcctccatac     1320

gcagcacctg agctcttcca gggcaagaaa tatgacgggc cagaagtgga tgtgtggagt     1380

ctgggggtca ttttatacac actagtcagt ggctcacttc cctttgatgg gcaaaaccta     1440

aaggaactga gagagagagt attaagaggg aaatacagaa ttcccttcta catgtctaca     1500

gactgtgaaa accttctcaa acgtttcctg gtgctaaatc caattaaacg cggcactcta     1560

gagcaaatca tgaaggacag gtggatcaat gcagggcatg aagaagatga actcaaacca     1620

tttgttgaac cagagctaga catctcagac caaaaaagaa tagatattat ggtgggaatg     1680

ggatattcac aagaagaaat tcaagaatct cttagtaaga tgaaatacga tgaaatcaca     1740

gctacatatt tgttattggg gagaaaatct tcagagctgg atgctagtga ttccagttct     1800

agcagcaatc tttcacttgc taaggttagg ccgagcagtg atctcaacaa cagtactggc     1860

cagtctcctc accacaaagt gcagagaagt gttttttcaa gccaaaagca aagacgctac     1920

agtgaccatg ctggaccagc tattccttct gttgtggcgt atccgaaaag gagtcagacc     1980

agcactgcag atagtgacct caaagaagat ggaatttcct cccggaaatc aagtggcagt     2040

gctgttggag gaaagggaat tgctccagcc agtcccatgc ttgggaatgc aagtaatcct     2100

aataaggcgg atattcctga acgcaagaaa agctccactg tccctagtag taacacagca     2160

tctggtggaa tgacacgacg aaatacttat gtttgcagtg agagaactac agctgataga     2220

cactcagtga ttcagaatgg caaagaaaac agcactattc ctgatcagag aactccagtt     2280

gcttcaacac acagtatcag tagtgcagcc accccagatc gaatccgctt cccaagaggc     2340

actgccagtc gtagcacttt ccacggccag ccccgggaac ggcgaaccgc aacatataat     2400

ggccctcctg cctctcccag cctgtcccat gaagccacac cattgtccca gactcgaagc     2460

cgaggctcca ctaatctctt tagtaaatta acttcaaaac tcacaaggag aaacatgtca     2520

ttcaggttta tcaaaaggct tccaactgaa tatgagagga acgggagata tgagggctca     2580

agtcgcaatg tatctgctga gcaaaaagat gaaaacaaag aagcaaagcc tcgatcccta     2640

cgcttcacct ggagcatgaa aaccactagt tcaatggatc ccggggacat gatgcgggaa     2700

atccgcaaag tgttggacgc caataactgc gactatgagc agagggagcg cttcttgctc     2760

ttctgcgtcc acggagatgg gcacgcggag aacctcgtgc agtgggaaat ggaagtgtgc     2820

aagctgccaa gactgtctct gaacggggtc cggtttaagc ggatatcggg gacatccata     2880

gccttcaaaa atattgcttc caaaattgcc aatgagctaa agctgtaacc cagtgattat     2940

gatgtaaatt aagtagcaat taaagtgttt tcctgaacac tgatggaaat gtatagaata     3000

atatttaggc aataacgtct gcatcttcta aatcatgaaa ttaaagtctg aggacgagag     3060

cacgcctggg agcgaaagct ggcctttttt ctacgaatgc actacattaa agatgtgcaa     3120

cctatgcgcc ccctgcccta cttccgttac cctgagagtc ggtgtgtggc cccatctcca     3180

tgtgcctccc gtctgggtgg gtgtgagagt ggacggtatg tgtgtgaagt ggtgtatatg     3240

gaagcatctc cctacactgg cagccagtca ttactagtac ctctgcggga gatcatccgg     3300

tgctaaaaca ttacagttgc caaggaggaa aatactgaat gactgctaag aattaacctt     3360

aagaccagtt catagttaat acaggtttac agttcatgcc tgtggttttg tgtttgttgt     3420

tttgtgtttt tttagtgcaa aaggtttaaa tttatagttg tgaacattgc ttgtgtgtgt     3480

ttttctaagt agattcacaa gataattaaa aattcacttt ttctcagtaa aaaaaaaaaa     3540

aaaaaa                                                                3546


<210>  52
<211>  1667
<212>  DNA
<213>  Homo sapiens

<400>  52
cttctaggaa aggtggagtc ggtagtgaga agccggaggt gagaagaccc ctgagcggat       60

ggattcattc attttctgaa tttcctatgt gaggacagta ttagagccca gtgaggcttt      120

gagaggcccc aaagatgagc gccaacagca gcagagtggg ccagcttctc ttgcagggtt      180

cagcgtgcat taggtggaag caggatgtgg aaggggctgt ctaccaccta gccaactgcc      240

tcttactcct gggcttcatg gggggcagtg gggtgtatgg atgcttctat ctttttggct      300

tcctgagtgc aggttacctg tgctgcgtgc tgtggggctg gttcagtgcc tgtggcctgg      360

acattgttct ttggagcttc ctgctggctg tggtctgcct gctccagctg gcacacctgg      420

tataccgcct gcgtgaggac accctccctg aggagtttga cctcctctac aagacgctgt      480

gcctgccctt gcaggtgccc ctacagacat acaaggagat tgttcactgc tgcgaggagc      540

aggtcttaac tctggccact gaacagacct atgctgtgga gggtgagaca cccatcaacc      600

gcctgtccct gctgctctct ggccgggttc gtgtgagcca ggatgggcag tttctgcact      660

acatctttcc ataccagttc atggactctc ctgagtggga atcactacag ccttctgagg      720

agggggtgtt ccaggtcact ctgactgctg agacctcatg tagctacatt tcctggcccc      780

ggaaaagtct ccatcttctt ctgaccaaag agcgatacat ctcctgcctc ttctcggctc      840

tgctgggata tgacatctca gagaagctct acactctcaa tgacaagctc tttgctaagt      900

ttgggctgcg ctttgacatc cgccttccca gcctctacca tgtcctgggt cccactgctg      960

cagatgctgg accagagtcc gagaagggtg atgaggaagt ctgtgagcca gctgtgtccc     1020

ctcctcaggc cacacccacc tctctccagc aaacaccccc ttgttctacc cctccagcta     1080

ccaccaactt tcctgcacct cctacccggg ccaggttgtc caggccagac agtggcatac     1140

tggcttctag aattcctctc cagagctact ctcaagttat atccagggga caggcccctt     1200

tggctccaac ccacacgcct gaactttaag gatcattgga ctatcttctc tgtggccagc     1260

gcagctctct tctgtgttca cagaatggcc actgataggc atgcctcttt tcccacccac     1320

tggaaggctc acaggcaagg tgagagagga cacagaaggt gccaacactg tcgctacagt     1380

aaggacctga agtgactttg agaaattcac cctcacaaac cttccttcag gagcaggcat     1440

tggtagtgca gaggcacaga ttccgtcctt taccagctgc agaatcttgg gcaagttaca     1500

tagcctctgt gagcctcatc ggtaaacagt gggggttatg aaacccacct cacagggttg     1560

ttgtgaggat ccaatgagtt gatttaggta agcacctagc acatgccgtg gcaccaagta     1620

agcactcaat aaatcactca actcttaaaa aaaaaaaaaa aaaaaaa                   1667


<210>  53
<211>  1543
<212>  DNA
<213>  Homo sapiens

<400>  53
ggagtggcca ttcgacgaca gtgtggtgta aaggaattca ttagccatgg atgtattcat       60

gaaaggactt tcaaaggcca aggagggagt tgtggctgct gctgagaaaa ccaaacaggg      120

tgtggcagaa gcagcaggaa agacaaaaga gggtgttctc tatgtaggct ccaaaaccaa      180

ggagggagtg gtgcatggtg tggcaacagt ggctgagaag accaaagagc aagtgacaaa      240

tgttggagga gcagtggtga cgggtgtgac agcagtagcc cagaagacag tggagggagc      300

agggagcatt gcagcagcca ctggctttgt caaaaaggac cagttgggca agaatgaaga      360

aggagcccca caggaaggaa ttctggaaga tatgcctgtg gatcctgaca atgaggctta      420

tgaaatgcct tctgaggaag ggtatcaaga ctacgaacct gaagcctaag aaatatcttt      480

gctcccagtt tcttgagatc tgctgacaga tgttccatcc tgtacaagtg ctcagttcca      540

atgtgcccag tcatgacatt tctcaaagtt tttacagtgt atctcgaagt cttccatcag      600

cagtgattga agtatctgta cctgccccca ctcagcattt cggtgcttcc ctttcactga      660

agtgaataca tggtagcagg gtctttgtgt gctgtggatt ttgtggcttc aatctacgat      720

gttaaaacaa attaaaaaca cctaagtgac taccacttat ttctaaatcc tcactatttt      780

tttgttgctg ttgttcagaa gttgttagtg atttgctatc atatattata agatttttag      840

gtgtctttta atgatactgt ctaagaataa tgacgtattg tgaaatttgt taatatatat      900

aatacttaaa aatatgtgag catgaaacta tgcacctata aatactaaat atgaaatttt      960

accattttgc gatgtgtttt attcacttgt gtttgtatat aaatggtgag aattaaaata     1020

aaacgttatc tcattgcaaa aatattttat ttttatccca tctcacttta ataataaaaa     1080

tcatgcttat aagcaacatg aattaagaac tgacacaaag gacaaaaata taaagttatt     1140

aatagccatt tgaagaagga ggaattttag aagaggtaga gaaaatggaa cattaaccct     1200

acactcggaa ttccctgaag caacactgcc agaagtgtgt tttggtatgc actggttcct     1260

taagtggctg tgattaatta ttgaaagtgg ggtgttgaag accccaacta ctattgtaga     1320

gtggtctatt tctcccttca atcctgtcaa tgtttgcttt atgtattttg gggaactgtt     1380

gtttgatgtg tatgtgttta taattgttat acatttttaa ttgagccttt tattaacata     1440

tattgttatt tttgtctcga aataattttt tagttaaaat ctattttgtc tgatattggt     1500

gtgaatgctg tacctttctg acaataaata atattcgacc atg                       1543


<210>  54
<211>  2319
<212>  DNA
<213>  Homo sapiens

<400>  54
gcaggggcgg ggcctgagtc agcgcagttc ggccggggtc tccccggcgc tgcccagtct       60

gtctccggcg ccgcccgtcg cggactcgtc cttgctgcag tcgccgccgc agtcctcgcc      120

gcagtcgccg ccgccgccgc cgccgccgcc gctgctcctc cgcctggcct gggccgtctg      180

cccgcagcca tgagcgtgct cggccccggt ggagcccgca gtcctctaga ttagtctcca      240

ccgccgtcca ggacccactt gcagcatgga gtcgcccgcc tcgagccagc ccgccagcat      300

gccccagtcc aaaggaaaat ccaagaggaa gaaggatcta cggatatcct gcatgtccaa      360

gccacccgca cccaacccca cacccccccg gaacctggac tcccggacct tcatcaccat      420

tggagacaga aactttgagg tggaggctga tgacttggtg accatctcag aactgggccg      480

tggagcctat ggggtggtag agaaggtgcg gcacgcccag agcggcacca tcatggccgt      540

gaagcggatc cgggccaccg tgaactcaca ggagcagaag cggctgctca tggacctgga      600

catcaacatg cgcacggtcg actgtttcta cactgtcacc ttctacgggg cactattcag      660

agagggagac gtgtggatct gcatggagct catggacaca tccttggaca agttctaccg      720

gaaggtgctg gataaaaaca tgacaattcc agaggacatc cttggggaga ttgctgtgtc      780

tatcgtgcgg gccctggagc atctgcacag caagctgtcg gtgatccaca gagatgtgaa      840

gccctccaat gtccttatca acaaggaggg ccatgtgaag atgtgtgact ttggcatcag      900

tggctacttg gtggactctg tggccaagac gatggatgcc ggctgcaagc cctacatggc      960

ccctgagagg atcaacccag agctgaacca gaagggctac aatgtcaagt ccgacgtctg     1020

gagcctgggc atcaccatga ttgagatggc catcctgcgg ttcccttacg agtcctgggg     1080

gaccccgttc cagcagctga agcaggtggt ggaggagccg tccccccagc tcccagccga     1140

ccgtttctcc cccgagtttg tggacttcac tgctcagtgc ctgaggaaga accccgcaga     1200

gcgtatgagc tacctggagc tgatggagca ccccttcttc accttgcaca aaaccaagaa     1260

gacggacatt gctgccttcg tgaaggagat cctgggagaa gactcatagg ggctgggcct     1320

cggaccccac tccggccctc cagagcccca cagccccatc tgcgggggca gtgctcaccc     1380

acaccataag ctactgccat cctggcccag ggcatctggg aggaaccgag ggggctgctc     1440

ccacctggct ctgtggcgag ccatttgtcc caagtgccaa agaagcagac cattggggct     1500

cccagccagg cccttgtcgg ccccaccagt gcctctccct gctgctccta ggacccgtct     1560

ccagctgctg agatcctgga ctgagggggc ctggatgccc cctgtggatg ctgctgcccc     1620

tgcacagcag gctgccagtg cctgggtgga tgggccaccg ccttgcccag cctggatgcc     1680

atccaagttg tatatttttt taatctctcg actgaatgga ctttgcacac tttggcccag     1740

ggtggccaca cctctatccc ggctttggtg cggggtacac aagaggggat gagttgtgtg     1800

aataccccaa gactcccatg agggagatgc catgagccgc ccaaggcctt cccctggcac     1860

tggcaaacag ggcctctgcg gagcacactg gctcacccag tcctgcccgc caccgttatc     1920

ggtgtcattc acctttcgtg ttttttttaa tttatcctct gttgattttt tcttttgctt     1980

tatgggtttg gcttgttttt cttgcatggt ttggagctga tcgcttctcc cccaccccct     2040

agggtaccag caggcagagc cttgccctct gctcaggctg gggtccagtg ggaggggccc     2100

aagatctctg ctcagagaag tgcaggggga gccttccagc tcactctccc tgaggactgg     2160

cttgacaggg gctatgggtt tgctttggtg ttgtttttaa aaaaagaaaa tatatttttt     2220

tgaaaaaacg actgcccatc ccgggtcctt tccctgatgg gttggggcag ttacctggtt     2280

gctgttttaa ttaaaaaaaa aaaaaaaaaa aggactaaa                            2319


<210>  55
<211>  2578
<212>  DNA
<213>  Homo sapiens

<400>  55
gcctgtctcc cggtgcagct gtgttcgcgg cctgcaggcc caacatggcg caggaggtgt       60

cggagtacct gagccagaac ccgcgggtgg cagcctgggt ggaggcgctg cgctgcgacg      120

gcgagactga caaacactgg cgccaccgcc gggatttttt gcttcgcaac gccggggacc      180

tggcccccgc tggcggcgct gcctccgcta gcacggatga agctgccgac gccgagagcg      240

ggacccgaaa ccggcagctg cagcagctca tctccttttc catggcctgg gcgaaccacg      300

tcttcctcgg gtgccgatac cctcaaaaag ttatggataa aatacttagt atggctgaag      360

gcatcaaagt gacagatgct ccaacctata caacaagaga tgaactggtt gccaaggtga      420

agaaaagagg gatatcgagt agcaatgaag gggtagaaga gccatccaaa aaacgagtta      480

tagaaggaaa aaacagttct gcagttgagc aagatcacgc aaaaacctct gccaagacag      540

aacgtgcatc agctcagcag gaaaacagtt caacgtgtat agggtcggcc atcaaatcag      600

agagtgggaa ctcagctcgg agctctggca tctccagtca gaatagctct acaagtgatg      660

gagatcgatc tgtttccagc caaagcagca gcagcgtttc ctctcaggta acaacggcag      720

gatctgggaa agcttctgaa gcagaagctc cagataaaca cggttcatca tttgtttcct      780

tgctgaaatc cagtgtgaat agtcacatga cccaatccac tgattctaga caacaaagtg      840

gatcacctaa aaagagtgct ttggaaggct cttcagcctc agcttctcaa agcagctcag      900

agatcgaggt gcccttgttg ggctcctcag gaagctcaga ggtagaattg ccactattgt      960

cttccaaacc tagttcagag acagcttcaa gtgggttaac ttccaaaact agttcagagg     1020

caagtgtttc atcatcagtt gctaaaaaca gttcctcatc aggcacatcc ttactgactc     1080

ccaagagcag ctcttcaaca aatacatcgc tgctaacttc caagagcact tcccaggtag     1140

ctgcatcact actagcttcc aagagcagct cccagaccag tggatctctg gtttccaaaa     1200

gcacttcctt agcaagtgtg tcccagttgg cttctaagag tagttctcag actagcacct     1260

cacagttgcc ttctaaaagt acttcacagt caagtgagag ttctgtcaaa ttctcttgca     1320

agttaaccaa tgaagatgtg aaacagaagc aacctttttt caatagacta tataaaacgg     1380

tggcatggaa gttggtagct gttggtggct ttagtcccaa tgtgaatcat ggagagctcc     1440

taaatgcagc tattgaggct ctgaaagcaa cactggatgt attttttgtc ccactaaaag     1500

aattggcaga tctgcctcaa aataagagct ctcaagaaag tattgtttgt gaattgaggt     1560

gcaagtctgt gtatttgggc actggctgtg gaaaaagcaa agaaaatgca aaagcagttg     1620

catcaagaga agcattgaag ttatttctca agaaaaaggt ggtggtaaaa atatgtaaaa     1680

ggaaatacag aggcagtgaa atagaagatc tagtactcct tgatgaagaa tcgaggcctg     1740

taaacttacc tccagcacta aaacatcctc aagaattact ataatgtgtc caaaatatca     1800

ctgcatacaa tatctggtat ttgaagagaa aaactgactt ttgtatagta taaaacacag     1860

gctttcacaa attttgtatt gctttttttc cagttttgca gaaaatttac attctagttc     1920

tcttcacaca gtagcagttg taaataattt atgaatgaca gtacacatta aaaggtatgc     1980

attagcagca tattagtatg ctgttttatt tgctgaagaa aatactgtct tctattttta     2040

atgatacatt aggtacgatg tgtttcggta gagtcctaaa atttttgtac tactttcaat     2100

ttggtgaaaa tgtattaagt tgtctaccat gttttctttt ctagctgaat aaaccacatc     2160

aaaggaaagg gaccacagta tttgaatgtt tgaaagtctg taaagcttaa ggttttaaaa     2220

atgttgcccg taatgttgaa cgtgtctgtt aaaaaataaa agaaaaaata gttgcttcaa     2280

actattttta tgagaagttg taagcatttt ttagatataa agcagtataa agtacttgtt     2340

attttactct gaagttgttt aaaattcacc atgactttga ccgctgaaga ttctttaagc     2400

gggttaattt atgttttgag gtggaataca atttacactt ttttcttaaa aacatgaatg     2460

tgggtttcta tattaagcat attttgtgac tactattaac agattgattt gtttagatat     2520

taaatgcttt aagctatttt acctttacaa aaaaaaaaaa aaaaaaaaaa aaaaaaaa       2578


<210>  56
<211>  2657
<212>  DNA
<213>  Homo sapiens

<400>  56
gtcacctggg aagagtctgc agagcctttg cccgccagcg ccttcgctct ttggctccct       60

gagttaatcc ggttgtttgc gatcgccgcg gccggggctg cgaaccgaag ggctcgctcc      120

gcgccgcctg ggtctctacc tcatccgtag gtgtggccct gatggtgtgg caggctctgg      180

actcctaaag ctctggagcg aatttaagat tttattcatg tgcatggcat agaagatgaa      240

ttcttccact tccaccatga gtgaagagcc tgacgctcta tcggtagtta accagttacg      300

ggatctagca gcagatccgt taaacagaag agccatcgtc caggatcagg gatgtctgcc      360

tggccttatt ttatttatgg accatcccaa ccctccagtc gtccactccg ctttgcttgc      420

tcttcgatac ttggcagaat gccgtgcaaa cagagaaaag atgaaaggag aactgggtat      480

gatgttgagc ttacaaaatg ttatacagaa aactacaact ccaggagaaa caaaacttct      540

ggcctctgaa atctatgaca ttcttcagtc ctccaatatg gcagatggtg atagttttaa      600

tgagatgaat tcacgtcgaa ggaaagctca attttttctg ggaactacaa acaaacgtgc      660

caaaacagtg gttttgcata tagatggcct tgatgatacg tctcggagaa atctatgtga      720

agaggctttg ttaaaaatta aaggtgttat tagctttact tttcaaatgg ctgttcaaag      780

gtgtgtggtg cgaatccgtt cagatttgaa agctgaggct ttggcatcag caatagcatc      840

aaccaaggtt atgaaagctc agcaagttgt gaaaagtgaa agtggagaag agatgttggt      900

cccattccaa gatactcctg tggaagttga acagaacaca gagctacctg actacctgcc      960

tgaggatgag agtcccacaa aggaacagga caaagcggtg tcccgggtcg gctcacaccc     1020

agaaggtgga gctagctggc ttagcacagc tgcaaacttt ttatccagat cattttattg     1080

gtgacttcac ttttgggctc aaggactgtg tgaaccaaca aggggccagt tttccattgt     1140

tgtggtgaac tgtcaagtgc aatttgcaat aagttatcat gaaaagtttt tagattacac     1200

gatcgcatat gctgcatttc acattttatt ggacatttta ccccactgag tggtaaaaag     1260

gacagaggct acagatggag ttgctttgtt tatgaaagta ttttggtttg ttttctttca     1320

tttaattgcc tcatatttaa aaaccatggg tccactgtta aaaccacatg tgtatgtgca     1380

gctttacatt ttattttacg tgaagcatgt gattaggaaa actcattttc ttttcaagcc     1440

tcaggaccta cctgaagaga agttttcttg tagctcaagt tgtgcatgaa ttactgaata     1500

ttttactgtg cttttcttca tgaagggtac atgctttgta ctcttcactg aaagctgaaa     1560

acatttcttg ttaccctctt ttgtgccttt ttattttgcc aaccgtgttt atagaaagga     1620

cattactaat gacattttgc agattaaaaa cattcatttg aacacagtag tcccctagaa     1680

aaacaactct acaaaaattt tgcagcctta ttcattataa ttttgataaa attaacacaa     1740

aatcagtcaa gaaggaaaca tgtatattag tgaagtgttt ttggagactg tttgaatgtg     1800

accaaatgtg gttctagttg acttcttttc actttggctt atatcaattc ttgagagtta     1860

atgtgatcat gatattgcaa acaactataa atggtctcta ggccttactt tgtgattata     1920

cgttatctcc ggctagaaaa aaataatggt agtaaagaaa ctgacaaact gaaaataaga     1980

aaacaaaaat caaatgccta taataccata atgccagttt ggtatagagt ccaactttaa     2040

aacatgaatt gctcgacaga gttctattca gtaggtgttt ctttgtattg tcttttgtga     2100

atttattatg aaaatgctgc gttgtgttga atgaaaaaga cccaaattac tgcttatgaa     2160

gaaataaagc cagcattgat cacttaatcc tgtttctcat gtccagccag aaaaaagaac     2220

ttcagtgaag gtaagataaa taaatacata cacatatgtt tttttggtag ataagtgcta     2280

attacatata tgtaatgctt tattaaattt ctgaaatatt tggtaactaa aattttcttt     2340

ttggaaatta ataaatccag atacatatta atgttgatat gagtaaaaac aaataggaag     2400

aaattgaaat ttcttttcat caacatgtag agctgctatt ttactatttg gagaatatga     2460

tgtgaaaatt ggacctcaaa gggtttcctt gtgttttcat tgtaaaatac catcatcagt     2520

gagagtcttg agttcactaa cattgtcacc ttctggagag agagttaatg gggggcattg     2580

aggatgatat ttttttacat gtgtttggtt tctgattcaa gtgacacgca caaactgaaa     2640

aaaaaaaaaa aaaaaaa                                                    2657


<210>  57
<211>  1173
<212>  DNA
<213>  Homo sapiens

<400>  57
ggcacgaggc tgccctagtg gcctatgtcc cttgctcggg gccatggaga cactgcggcc       60

agtacggcgg cgcctctgtc tgaagaaggg gaagtgacct ccggcctcca ggctctggcc      120

gtggaggata ccggaggccc ctctgcctcg gccggtaagg ccgaggacga gggggaagga      180

ggccgagagg agaccgagcg tgaggggtcc gggggcgagg aggcgcaggg agaagtcccc      240

agcgctgggg gagaagagcc tgccgaggag gactccgagg actggtgcgt gccctgcagc      300

gacgaggagg tggagctgcc tgcggatggg cagccctgga tgcccccgcc ctccgaaatc      360

cagcggctct atgaactgct ggctgcccac ggtactctgg agctgcaagc cgagatcctg      420

ccccgccggc ctcccacgcc ggaggcccag agcgaagagg agagatccga tgaggagccg      480

gaggccaaag aagaggaaga ggaaaaacca cacatgccca cggaatttga ttttgatgat      540

gagccagtga caccaaagga ctccctgatt gaccggagac gcaccccagg aagctcagcc      600

cggagccaga aacgggaggc ccgcctggac aaggtgctgt cggacatgaa gagacacaag      660

aagctggagg agcagatcct tcgtaccggg agggacctct tcagcctgga ctcggaggac      720

cccagccccg ccagcccccc actccgatcc tccgggagta gtctcttccc tcggcagcgg      780

aaatactgat tcccactgct cctgcctcta gggtgcagtg tccgtacctg ctggagcctg      840

ggccctcctt ccccagccca gacattgaga aacttgggaa gaagagagaa acctcaagct      900

cccaaacagc acgttgcggg aaagaggaag agagagtgtg agtgtgtgtg tgtgtttttt      960

ctattgaaca cctgtagagt gtgtgtgtgt gttttctatt gaacacctat agagagagtg     1020

tgtgtgtttt ctattgaaca tctatataga gagagtgtgt gagtgtgtgt tttctattga     1080

acacctattc agagacctgg actgaatttt ctgagtctga aataaaagat gcagagctat     1140

catctcttaa aaaaaaaaaa aaaaaaaaaa aaa                                  1173


<210>  58
<211>  2591
<212>  DNA
<213>  Homo sapiens

<400>  58
ctcagactgt ccttcctctc tggactgtaa gaatatgtct ccagggccag tgtctgctgc       60

gatcgagtcc caccttccaa gtcctggcat ctcaatgcat ctgggaagct acctgcatta      120

agtcaggact gagcacacag gtgaactcca gaaagaagaa gctatggccg cagtgattct      180

ggagagcatc tttctgaagc gatcccaaca gaaaaagaaa acatcacctc taaacttcaa      240

gaagcgcctg tttctcttga ccgtgcacaa actctcctac tatgagtatg actttgaacg      300

tgggagaaga ggcagtaaga agggttcaat agatgttgag aagatcactt gtgttgaaac      360

agtggttcct gaaaaaaatc ctcctccaga aagacagatt ccgagaagag gtgaagagtc      420

cagtgaaatg gagcaaattt caatcattga aaggttccct tatcccttcc aggttgtata      480

tgatgaaggg cctctctacg tcttctcccc aactgaagaa ctaaggaagc ggtggattca      540

ccagctcaaa aacgtaatcc ggtacaacag tgatctggtt cagaaatatc acccttgctt      600

ctggatcgat gggcagtatc tctgctgctc tcagacagcc aaaaatgcta tgggctgcca      660

aattttggag aacaggaatg gaagcttaaa acctgggagt tctcaccgga agacaaaaaa      720

gcctcttccc ccaacgcctg aggaggacca gatcttgaaa aagccactac cgcctgagcc      780

agcagcagca ccagtctcca caagtgagct gaaaaaggtt gtggcccttt atgattacat      840

gccaatgaat gcaaatgatc tacagctgcg gaagggtgat gaatatttta tcttggagga      900

aagcaactta ccatggtgga gagcacgaga taaaaatggg caggaaggct acattcctag      960

taactatgtc actgaagcag aagactccat agaaatgtat gagtggtatt ccaaacacat     1020

gactcggagt caggctgagc aactgctaaa gcaagagggg aaagaaggag gtttcattgt     1080

cagagactcc agcaaagctg gcaaatatac agtgtctgtg tttgctaaat ccacagggga     1140

ccctcaaggg gtgatacgtc attatgttgt gtgttccaca cctcagagcc agtattacct     1200

ggctgagaag caccttttca gcaccatccc tgagctcatt aactaccatc agcacaactc     1260

tgcaggactc atatccaggc tcaaatatcc agtgtctcaa caaaacaaga atgcaccttc     1320

cactgcaggc ctgggatacg gatcatggga aattgatcca aaggacctga ccttcttgaa     1380

ggagctgggg actggacaat ttggggtagt gaagtatggg aaatggagag gccagtacga     1440

cgtggccatc aagatgatca aagaaggctc catgtctgaa gatgaattca ttgaagaagc     1500

caaagtcatg atgaatcttt cccatgagaa gctggtgcag ttgtatggcg tctgcaccaa     1560

gcagcgcccc atcttcatca tcactgagta catggccaat ggctgcctcc tgaactacct     1620

gagggagatg cgccaccgct tccagactca gcagctgcta gagatgtgca aggatgtctg     1680

tgaagccatg gaatacctgg agtcaaagca gttccttcac cgagacctgg cagctcgaaa     1740

ctgtttggta aacgatcaag gagttgttaa agtatctgat ttcggcctgt ccaggtatgt     1800

cctggatgat gaatacacaa gctcagtagg ctccaaattt ccagtccggt ggtccccacc     1860

ggaagtcctg atgtatagca agttcagcag caaatctgac atttgggctt ttggggtttt     1920

gatgtgggaa atttactccc tggggaagat gccatatgag agatttacta acagtgagac     1980

tgctgaacac attgcccaag gcctacgtct ctacaggcct catctggctt cagagaaggt     2040

atataccatc atgtacagtt gttggcatga gaaagcagat gagcgtccca ctttcaaaat     2100

tcttctgagc aatattctag atgtcatgga tgaagaatcc tgagctcgcc aataagcttc     2160

ttggttctac ttctcttctc cacaagcccc aatttcactt tctcagagga aatcccaagc     2220

ttaggagccc tggagccttt gtgctcccac tcaatacaaa aaggcccctc tctacatctg     2280

gggatgcacc tcttctttga ttccctggga tagtggcttc tgagcaaagg ccaaaaaatt     2340

attgtgcctg aaatttcccg agagaattaa gacagactga atttgcgatg aaaatatttt     2400

ttaggaggga ggatgtaaat agccgcacaa aggggtccaa cagctctttg agtaggcatt     2460

tggtagagct tgggggtgtg tgtgtggggg tggaccgaat ttggcaagaa tgaaatggtg     2520

tcataaagat gggaggggag ggtgttttga taaaataaat tctagaaagc ttaaaaaaaa     2580

aaaaaaaaaa a                                                          2591


<210>  59
<211>  1320
<212>  DNA
<213>  Homo sapiens

<400>  59
ggggggggcg tctttggggc ttctggcaga tggcgggttc ctccgcgaga gccgagaacc       60

gcctactcca ggaggaaagc ccgagggttg tgggtcctgc tatagccagg gccaagctcc      120

aggaaatcgt ggccattcag gggtagtttg cagcctcatt tgtaacatta ttgtgttgtc      180

ctgtgcattt ccaatgcatt acataaagac atggtcgctt ttaggagaaa tgtctgaaaa      240

actaagaaga tgcagaaagg aactgactgc agccattgac cgggcctttg aaggagttag      300

ttattcccag gagtgcacag gccagcagag gctggaactg agcgccgcgc cgctctcctt      360

ctcgctgccc gtgcacaggc tcctctgcag aagacatcct ctgtcagcct gctcttctgc      420

tgctcctttt gctgctgtcc catgtgctcc tgagaatgag aaccctgcct ttgcaacaaa      480

ccatgccccg gtaaatgcaa aaccacatgc tctgtgcccc gagagaaaac ctctaaccag      540

caaggaaaat gtattgatgc attcctccat tttggcacct gaaagagagt cttggagaac      600

tgcaggagag ggggaaaact ggagaaaaga aaatttaagg aaagatatgg agagagattt      660

gaaggctgac tcaaacatgc cactcaacaa ttctagccaa gaggtcacaa aggatctgct      720

tgatatgatt gaccatacaa gcatccgaac tattgaagaa ttggctggaa aaatagaatt      780

tgaaaacgaa ttgaaccaca tgtgtggtca ttgccaagat tcacccttca aagaggaagc      840

ctgggccctg ctcatggaca agagccctca gaaggccaca gatgctgacc ctggcagcct      900

caaacaggct tttgatgatc ataatattgt tgagactgtt ctggacttgg aagaggacta      960

caatgtgatg acgtctttta aataccaaat tgagtaagga cagttatcta agctttgatt     1020

ccttacagca ggaggctgcc cttgagcctg agcagaagca gctacaatgg ccgtcagggg     1080

ccacatttct caaaaggttg gcagaacctg aattaccaga ccctttttaa atcccagttg     1140

tgtccctttt taagctgtga gaccagtttt ttgaattcca ttgctttgaa atgtttccta     1200

ttactgattt ttttttttaa ctttccttga catcttgaat gtgttttttt gattgatgtt     1260

caatataccc agtacccatg gtaggtgtgg gtcatgggcc aaaaaaaaaa aaaaaaaaaa     1320


<210>  60
<211>  7858
<212>  DNA
<213>  Homo sapiens

<400>  60
gaggagccag aagcaaactt cagctgtctc agccggatcc gtggttccta catttggagg       60

agccgcgtgc cagaaggcgt aggaccccaa ggggggacaa ggaggactcc cgagtctccc      120

ttcgccgctc tgcgaggccg aagcggtgga ctgagccgct cgggacagcg gcaccggagg      180

aggctcggag aagatgcggg gctcggggcc ccggggtgcg ggacgccggc ggcccccaag      240

cggcggcggc gacaccccca tcaccccagc gtccctggcc ggctgctact ctgcacctcg      300

acgggctccc ctctggacgt gccttctcct gtgcgccgca ctccggaccc tcctggccag      360

ccccagcaac gaagtgaatt tattggattc acgcactgtc atgggggacc tgggatggat      420

tgcttttcca aaaaatgggt gggaagagat tggtgaagtg gatgaaaatt atgcccctat      480

ccacacatac caagtatgca aagtgatgga acagaatcag aataactggc ttttgaccag      540

ttggatctcc aatgaaggtg cttccagaat cttcatagaa ctcaaattta ccctgcggga      600

ctgcaacagc cttcctggag gactggggac ctgtaaggaa acctttaata tgtattactt      660

tgagtcagat gatcagaatg ggagaaacat caaggaaaac caatacatca aaattgatac      720

cattgctgcc gatgaaagct ttacagaact tgatcttggt gaccgtgtta tgaaactgaa      780

tacagaggtc agagatgtag gacctctaag caaaaaggga ttttatcttg cttttcaaga      840

tgttggtgct tgcattgctc tggtttctgt gcgtgtatac tataaaaaat gcccttctgt      900

ggtacgacac ttggctgtct tccctgacac catcactgga gctgattctt cccaattgct      960

cgaagtgtca ggctcctgtg tcaaccattc tgtgaccgat gaacctccca aaatgcactg     1020

cagcgccgaa ggggagtggc tggtgcccat cgggaaatgc atgtgcaagg caggatatga     1080

agagaaaaat ggcacctgtc aagtgtgcag acctgggttc ttcaaagcct cacctcacat     1140

ccagagctgc ggcaaatgtc cacctcacag ttatacccat gaggaagctt caacctcttg     1200

tgtctgtgaa aaggattatt tcaggagaga gtctgatcca cccacaatgg catgcacaag     1260

acccccctct gctcctcgga atgccatctc aaatgttaat gaaactagtg tctttctgga     1320

atggattccg cctgctgaca ctggtggaag gaaagacgtg tcatattata ttgcatgcaa     1380

gaagtgcaac tcccatgcag gtgtgtgtga ggagtgtggc ggtcatgtca ggtaccttcc     1440

ccggcaaagc ggcctgaaaa acacctctgt catgatggtg gatctactcg ctcacacaaa     1500

ctataccttt gagattgagg cagtgaatgg agtgtccgac ttgagcccag gagcccggca     1560

gtatgtgtct gtaaatgtaa ccacaaatca agcagctcca tctccagtca ccaatgtgaa     1620

aaaagggaaa attgcaaaaa acagcatctc tttgtcttgg caagaaccag atcgtcccaa     1680

tggaatcatc ctagagtatg aaatcaagta ttttgaaaag gaccaagaga ccagctacac     1740

gattatcaaa tctaaagaga caactattac tgcagagggc ttgaaaccag cttcagttta     1800

tgtcttccaa attcgagcac gtacagcagc aggctatggt gtcttcagtc gaagatttga     1860

gtttgaaacc accccagtgt ttgcagcatc cagcgatcaa agccagattc ctgtaattgc     1920

tgtgtctgtg acagtgggag tcattttgtt ggcagtggtt atcggcgtcc tcctcagtgg     1980

aagttgctgc gaatgtggct gtgggagggc ttcttccctg tgcgctgttg cccatccaag     2040

cctaatatgg cggtgtggct acagcaaagc aaaacaagat ccagaagagg aaaagatgca     2100

ttttcataat gggcacatta aactgccagg agtaagaact tacattgatc cacataccta     2160

tgaggatccc aatcaagctg tccacgaatt tgctaaggag atagaagcat catgtatcac     2220

cattgagaga gttattggag caggtgaatt tggtgaagtt tgtagtggac gtttgaaact     2280

accaggaaaa agagaattac ctgtggctat caaaaccctt aaagtaggct atactgaaaa     2340

gcaacgcaga gatttcctag gtgaagcaag tatcatggga cagtttgatc atcctaacat     2400

catccattta gaaggtgtgg tgaccaaaag taaaccagtg atgatcgtga cagagtatat     2460

ggagaatggc tctttagata catttttgaa gaaaaacgat gggcagttca ctgtgattca     2520

gcttgttggc atgctgagag gtatctctgc aggaatgaag tacctttctg acatgggcta     2580

tgtgcataga gatcttgctg ccagaaacat cttaatcaac agtaaccttg tgtgcaaagt     2640

gtctgacttt ggactttccc gggtactgga agatgatccc gaggcagcct acaccacaag     2700

gggaggaaaa attccaatca gatggactgc cccagaagca atagctttcc gaaagtttac     2760

ttctgccagt gatgtctgga gttatggaat agtaatgtgg gaagttgtgt cttatggaga     2820

gagaccctac tgggagatga ccaatcaaga tgtgattaaa gcggtagagg aaggctatcg     2880

tctgccaagc cccatggatt gtcctgctgc tctctatcag ttaatgctgg attgctggca     2940

gaaagagcga aatagcaggc ccaagtttga tgaaatagtc aacatgttgg acaagctgat     3000

acgtaaccca agtagtctga agacgctggt taatgcatcc tgcagagtat ctaatttatt     3060

ggcagaacat agcccactag gatctggggc ctacagatca gtaggtgaat ggctagaggc     3120

aatcaagatg ggccggtata cagagatttt catggaaaat ggatacagtt caatggacgc     3180

tgtggctcag gtgaccttgg aggatttgag acggcttgga gtgactcttg tcggtcacca     3240

gaagaagatc atgaacagcc ttcaagaaat gaaggtgcag ctggtaaacg gaatggtgcc     3300

attgtaactt catgtaaatg tcgcttcttc aagtgaatga ttctgcactt tgtaaacagc     3360

actgagattt attttaacaa aaaaaggggg aaaagggaaa acagtgattt ctaaacctta     3420

gaaaacattt gcctcagcca cagaatttgt aatcatggtt ttactgaagt atccagttct     3480

tagtccttag tcttcatttt tcatgaagca aacatatctt gcattaaaag ggacatgaag     3540

ttagacatca tcttaagtta caacaacaga atccttccca ctacttctac aaaattttgt     3600

acatgaaata tataattata tagcactttt atagactgaa ttaaggcaac ccctttcaaa     3660

acttccaggg atctacttga aaggaaatgt tttatagcca tttgtgagct aacaaaagct     3720

acagtttact gaagtttact tcaagtctta attgtctaca aaagtgtatt gaagagcaat     3780

atgattagat tatttcttaa tagatatctt cttttgtaat tttaaaatgc tgttacacag     3840

cgttaagtta tagaaactag tgtgtaaaca tgttgcttga tcaagaaaaa gtacaataca     3900

gggtgtatat ttattttttg tgttataaag tttactttta gttgctcttc tagagattat     3960

taggtaataa atgtgtatat actgtataat ttgcaatata cccaggaact gatttaagat     4020

ggaattgtgt gtgtgtttgc ttgcacatgt gtgtgttacc attctgcttg catttctaat     4080

agtgtttcaa ttttagcaac atataggagc aagtgttcca gaatgtaata tgaataggag     4140

aaatagggaa gcagtaaaac aaaatttaac acaagcttgt gtctcttttc ctctcatgtg     4200

tccaaaagct aatctcttta ttcactaaaa ggaaatgtgt ataagactaa atcccctttg     4260

gctttttaaa aacattttgt gatatcagtg acaatgcagt tcttctagcc attaatcttg     4320

tacccctgta agaaatttca cctttctgag tcctgaaaag tatcttgtca agcaaagttg     4380

acaccgaagg gcacattttc agcaggatgt agaaggattt aactgtgcag gcttctgtta     4440

atgttgttaa atccaggcac atagcacgaa gcatcaccct taagtgttaa tccgttgtaa     4500

ccattcccat tttgactcag ttctagaaat tttgactcta aggcagcaat ggaattatga     4560

caaatatata tatatacaca tacacacaca caaatatata tatatgctta tttcccttca     4620

gaattttatt tcaataattg ataagtttta tttttaatgg atgtttattc atttgttaat     4680

ttcagtttgt attcagttac atggctttga gtttatttta ttgaaccaat ccaaggtatt     4740

atgtaattag gcttattaag gaatataaca tatcttctat gtatgctcta tataccacac     4800

atgatgaaga cttatatttg tgatacaaat tatgcagtgt attagaaatt gtccaaaact     4860

gagctcctga gataaccaac atttttgtat tattacactt tataaaaatt atggaatgtc     4920

atgtgattag tcaaaatcag agcatttaaa taaaatacag cctactcatg attatcaatg     4980

ttaatagtac agtagatcag agaagcctgg attaatgaaa tttatcagaa atatagccac     5040

gttatattaa tggtattctt ttttccaagc acttgtttta tttgaatatt agcacatata     5100

agaataaact tttgggaaat aactacttcc tattctgccc accctttact taagcagtaa     5160

agtacctctt ttctaaagaa ccaggaaaca tcaaaataac cacaacaaaa atctaaacag     5220

ttttcaaata atacattcag ttctcataat aataagggct atataccatg ggtccacaca     5280

aactgtgctg caaacatata atctattagt ttagtaaaat ttccagagat gtgaatttaa     5340

tattttcttg ataaaatcat aaaaaagcat caccattatt aaagatgcat ttgttcattt     5400

caataaacag aaattaatga aacaaattac ttttgtacaa aataaatgat gattatgtgg     5460

cactttattg aattttatag aaatattcca atctaagtga taaagtaaca actgagaaac     5520

ttcagaatga aagccttatt gattcaaaag gaaaattacc atatgcttta gggctgatga     5580

acttgccaca attgcttaga cataacaaag atattttcta cattgttttc caactttata     5640

tgctgaaaga taattaggag gtccgggtgg agtgtatcta aatgactaga actttaagtt     5700

gcaatataga ttttctcttt ttaacaaagg aagaatataa attaatttgg atcaaattta     5760

tttgccttct ttgcaatctt ggtgatcatt ttggaaagta aattgaaagg aaagttaaat     5820

agccacatag ttttcttttg catctcaatt tggttgagaa tttctaagga aggttaatat     5880

gactttagaa tgaataaaga gactgtcaaa caacaagtac tctccctaaa aaagaggaaa     5940

gaatgccttc ctaaaatatt tgtttcctat tgtatatgtc accaattgga aaatgccaat     6000

ctcatctgca agtgtgagaa atggaacaag gagaggagcc aactctagta aaatgtagtg     6060

aggccataat ccaaggcaaa gtttaacaaa tcttgattgt gtaatttctt attctgttga     6120

ttcattttgt cacccaccag actaccaaaa ataaagcaca gacatgacaa ttttagtata     6180

tacaacagat ttggcaaata atacataatc ttattgtaat tgccagtagc aatatcttaa     6240

ggggcatgag tctttcacag tattggactt tgaaaaattg gtacagggag taattttcaa     6300

cagactgata cttgaagtca ctcaattact actttgacct atcataattt gtttctaatc     6360

ttgtcatttg ctcatatata ctattaatat aaccagttgc tcttttcata atgtactatt     6420

tctatgtaaa gatgtaaaga ttttgatttt cctatgtttt aaaattgtaa tgtgcatgat     6480

cttttatttc ttgtgtttca attaccaagt cagtattcta aggttgtaag attactgtaa     6540

aaattatatt ccaatatttt atctaaactt aagtgtggcc agcattattg gtttcagagt     6600

tgcctaaaca acacagaata tccttaattc agtttgtaaa agagttttga ccagtgtaaa     6660

aaagtgaaga cacagtttca tgtttcaagt ttaaaatgga aagttaatat catttgagca     6720

cttatgtgtt ttcatgtctt ctacttaatc tgtatgtgaa agtaaaatat ttttaacacc     6780

attatttatg ccatgtaaag tgggttctca gaagcacaag cacagatatt taccttctga     6840

agacattttt ggctataaaa gtgcattgga tggcaaacac tatttgagtc aggtgttaga     6900

aatttattag atgtattata ttacatagta gaataaggtc cctttctcat tttgtttttc     6960

ctaaaaataa gaaaaaaaag aagtgtgata gtaaactgtc tttgctaatg tcctgccaga     7020

tgtttaactt caaattaagc aaaaagtagg tacaatatga tgatgatcct gatgatgatg     7080

atgatgatga tgatgaagaa taaatggaat caaaatgcta gctttatttg acattaataa     7140

gtaaaataag tcatcatttt ttcaactctg tagcacagct gtttacattg aataattttc     7200

tctattgtgc tgttaattat atagtaatgt atcaaaatag aaataggaac tttcttttca     7260

tttcttattc atttatgaag aaatcttttc acacataaat gattgaatgt tcttgttcag     7320

aatgaccaca taatcattgc ttagaagaag ataccaattc ttttaaaaga aaaaaagtct     7380

gtttataata atcagaatca aatgttgttt gtttcttcta aacgttaatg gagaaaattg     7440

aaggtggtaa aatgtcatgt ttattcaggc tgggaactgt attcacagta gaagtttcag     7500

tggtcaacat atctatgact ctttaggctg ctgtagtttt acagtcaatt atttaaaagt     7560

gagtagttac atttataaga gcctgagaat acttagactc agtcatttgt tagtattttt     7620

accaaaatct cttagtttca gacatgtcag aagcagctat atagcatatc ttattctatg     7680

atatacatca ggctatctca agttcctgtc tcacagttaa ttcaaagaag gattaggatt     7740

tctgtatttt ttctcatttg aatctttatg tgcatttggt ttgtgtacat gctttttgta     7800

gtgtaagata tgaaatttta tattttttca gaaaataaaa accctttgaa tacagtta       7858


<210>  61
<211>  955
<212>  DNA
<213>  Homo sapiens

<400>  61
cagcttcttc agagaaacag acggcaagcc aggtggagca gccaattata acccaaggat       60

cctctgttac aaagataact tttgaggggc gccagcctcc cacagttaca aagataactg      120

gtggcagttc tgtgcctaag ctgacatcac cagttacaag catatctccc attcaggcct      180

ctgagaagac agcagtgtct gacattttga aaatgtcttt gatggaagct cagattgata      240

caaatgtaga acatatgata gtggatcccc caaagaaggc tcttgccact agcatgctca      300

ctggtgaagc aggatcatta ccctccaccc acatggtggt ggcagggatg gcgaattcca      360

ctccccagca acagaaatgt agagagtcct gttcgagtcc atccactgtt ggctcttccc      420

taacgacaag gaaaattgat ccaccagcag tgcctgcgac aggccagttc atgcgtattc      480

agaatgtagg ccaaaagaaa gctgaagaga gtccagcaga aattatcatc caggctattc      540

ctcagtatgc tattccttgt cactccagct ccaatgtggt ggtggagccc agtgggcttc      600

ttgagctaaa caacttcact agtcaacagc tggatgatga ggagacagca atggagcagg      660

acatagacag tagcacggag gatggaactg aacccagccc ttctcagagc tctgctgaac      720

ggtcctagtg tttggacaca atagtgcact ttaaaacctg cttggttacc aagtgtccag      780

ggaaaccctt gtattttgat gactaaaaag agcactttgc ccgtacttag gctgtggacc      840

ctaaaacagc agtgtttcaa caagatgttg ctgcaggagc agctttttaa aacaagataa      900

aactcacagg ggaatgtact tttttaaaaa aaaaaaaaaa aaaaaaaaaa aaaaa           955


<210>  62
<211>  1908
<212>  DNA
<213>  Homo sapiens

<400>  62
cgccctgtga gggacaagcg tttgccgtag gggttgaaaa gaattggggt gcagtagttc       60

gctccccaga agggaccccc cagaaaatcc ggcagctgat agatgagggg attgccccgg      120

aagagggagg cgtggacgcg aaggacacgt ctgccacatc ccagtcagtt aatggatcac      180

cccaagcgga acaaccttca ttggaatcta caagcaaaga agccttcttt agcagagtgg      240

aaacattttc ttctttgaaa tgggcaggta agccctttga gctgtctcca ctcgtctgtg      300

caaaatatgg ctgggtcaca gtggaatgtg atatgctcaa gtgctctagc tgtcaagctt      360

ttctctgtgc cagtttacaa ccagcttttg actttgacag atataagcaa cgatgtgctg      420

agctgaagaa agccttgtgt actgcccatg agaagttctg tttctggcca gacagcccat      480

ccccagaccg atttgggatg ttgcccctgg atgagcctgc tattcttgtt agtgaattcc      540

tagatcgttt tcaaagcctt tgtcacttgg acctccagct tccttcccta aggccggagg      600

acttgaaaac tatgtgcttg acagaagaca agatcagtct tctcctacac ttgcttgaag      660

atgaacttga tcaccgaact gatgagagaa aaactacaat caaattaggc tcagacatcc      720

aagtccacgt cactgcctgt attctctctg tgtgtggctg ggcgtgtagt tcctctttgg      780

aatccatgca gctctccctg ataacatgtt cgcaatgtat gaggaaggtg gggctctggg      840

gcttccagca gattgaatcg tccatgactg acctggatgc atcctttggc ctgaccagct      900

ccccaatccc aggccttgag gggcgaccag agcgcttacc tctggtgcct gaatctcctc      960

ggaggatgat gacccggagc caggatgcca ctttctcccc aggctcagag caggctgaaa     1020

agagccctgg tcccattgtc tctcgaactc ggagctggga ctcttccagt cctgttgacc     1080

gtcctgagcc agaggctgct agccccacca ccagaactcg cccagtgacc cgaagcatgg     1140

gaacaggaga cacccctggc ctggaggtac catctagccc tctgcggaaa gccaagcgag     1200

ctcgcctctg ctcctccagc agttcggaca catcttcccg aagcttcttt gatcccacct     1260

ctcagcatag agactggtgc ccttgggtga atatcacact tggcaaagaa agcagggaga     1320

atggtggaac tgaaccagat gccagcgccc cagcagagcc aggctggaaa gcagtgctga     1380

ccatcctctt ggcgcacaaa cagtctagcc agccagctga aacggactcc atgagtctct     1440

ctgagaaatc aaggaaagta ttccgaatat ttcggcagtg ggaatctctg tgctcatgct     1500

gaagatactc cagcgccttc ctggagatag ctggaatgag agtgactttt tgaaaaatta     1560

aggctgagtt cctttcggtc agctgacact aagtttttcc tgttctgggt taatcataag     1620

gagccccctg ccatagcaaa ggcagtgagt gtcaactatc tgcatctggc tgagagagac     1680

ccgtttcctt tcagggatgt ggacagggta agggcagcaa gcatggttct gttaaaggag     1740

tgtggggtta acagactaga aggaagacta aggacctgac cacccatttc agcatcttca     1800

atgtggagca gtgttctgag gactcttcta tcctaggact atgacagtgt gtattaataa     1860

aatatttgct aagaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaa                  1908


<210>  63
<211>  2346
<212>  DNA
<213>  Homo sapiens

<400>  63
gcacgaggct gcggcgggtc cgggcccatg aggcgacgaa ggaggcggga cggcttttac       60

ccagccccgg acttccgaga cagggaagct gaggacatgg caggagtgtt tgacatagac      120

ctggaccagc cagaggacgc gggctctgag gatgagctgg aggagggggg tcagttaaat      180

gaaagcatgg accatggggg agttggacca tatgaacttg gcatggaaca ttgtgagaaa      240

tttgaaatct cagaaactag tgtgaacaga gggccagaaa aaatcagacc agaatgtttt      300

gagctacttc gggtacttgg taaagggggc tatggaaagg tttttcaagt acgaaaagta      360

acaggagcaa atactgggaa aatatttgcc atgaaggtgc ttaaaaaggc aatgatagta      420

agaaatgcta aagatacagc tcatacaaaa gcagaacgga atattctgga ggaagtaaag      480

catcccttca tcgtggattt aatttatgcc tttcagactg gtggaaaact ctacctcatc      540

cttgagtatc tcagtggagg agaactattt atgcagttag aaagagaggg aatatttatg      600

gaagacactg cctgctttta cttggcagaa atctccatgg ctttggggca tttacatcaa      660

aaggggatca tctacagaga cctgaagccg gagaatatca tgcttaatca ccaaggtcat      720

gtgaaactaa cagactttgg actatgcaaa gaatctattc atgatggaac agtcacacac      780

acattttgtg gaacaataga atacatggcc cctgaaatct tgatgagaag tggccacaat      840

cgtgctgtgg attggtggag tttgggagca ttaatgtatg acatgctgac tggagcaccc      900

ccattcactg gggagaatag aaagaaaaca attgacaaaa tcctcaaatg taaactcaat      960

ttgcctccct acctcacaca agaagccaga gatctgctta aaaagctgct gaaaagaaat     1020

gctgcttctc gtctgggagc tggtcctggg gacgctggag aagttcaagc tcatccattc     1080

tttagacaca ttaactggga agaacttctg gctcgaaagg tggagccccc ctttaaacct     1140

ctgttgcaat ctgaagagga tgtaagtcag tttgattcca agtttacacg tcagacacct     1200

gtcgacagcc cagatgactc aactctcagt gaaagtgcca atcaggtctt tctgggtttt     1260

acatatgtgg ctccatctgt acttgaaagt gtgaaagaaa agttttcctt tgaaccaaaa     1320

atccgatcac ctcgaagatt tattggcagc ccacgaacac ctgtcagccc agtcaaattt     1380

tctcctgggg atttctgggg aagaggtgct tcggccagca cagcaaatcc tcagacacct     1440

gtggaatacc caatggaaac aagtggcata gagcagatgg atgtgacaat gagtggggaa     1500

gcatcggcac cacttccaat acgacagccg aactctgggc catacaaaaa acaagctttt     1560

cccatgatct ccaaacggcc agagcacctg cgtatgaatc tatgacagag caatgctttt     1620

aatgaattta aggcaaaaag gtggagaggg agatgtgtga gcatcctgca aggtgaaaca     1680

agactcaaaa tgacagtttc agagagtcaa tgtcattaca tagaacactt cggacacagg     1740

aaaaataaac gtggatttta aaaaatcaat caatggtgca aaaaaaaact taaagcaaaa     1800

tagtattgct gaactcttag gcacatcaat taattgattc ctcgcgacat ctttctcaac     1860

cttatcaagg attttcatgt tgatgactcg aaactgacag tattaagggt aggatgttgc     1920

tctgaatcac tgtgagtctg atgtgtgaag aagggtatcc tttcattagg caagtacaaa     1980

ttgcctataa tacttgcaac taaggacaaa ttagcatgca agcttggtca aacttttccc     2040

aggcaaaatg ggaaggcaaa gacaaaagaa acttaccaat tgatgtttta cgtgcaaaca     2100

acctgaatct tttttttata taaatatata tttttcaaat agatttttga ttcagctcat     2160

tatgaaaaac atcccaaact ttaaaatgcg aaattattgg ttggtgtgaa gaaagccaga     2220

caacttctgt ttcttctctt ggtgaaataa taaaatgcaa atgaatcatt gttaacacag     2280

ctgtggctcg tttgagggat tggggtggac ctggggttta ttttcagtaa cccagctgcg     2340

gagcct                                                                2346


<210>  64
<211>  2110
<212>  DNA
<213>  Homo sapiens

<400>  64
aacatggcgg cggaaagtgg tagcgatttt cagcagagac gtagaaggcg ccgggacccg       60

gaggaaccgg aaaaaacaga actcagcgaa agagagctgg cagtagcagt ggcggtgtcc      120

caggagaacg atgaggagaa cgaagagcgc tgggttggac ctttacctgt ggaggcaaca      180

ctggccaaga agaggaaagt cttagagttt gaaagagtct atcttgataa tctccccagt      240

gcatccatgt atgagcgcag ttacatgcat agagatgtta tcacccatgt ggtatgcacc      300

aaaacagatt ttattattac tgccagtcat gatggacatg tcaagttctg gaaaaaaata      360

gaagagggaa ttgaatttgt taaacatttt cgtagtcacc tgggagttat tgagagtatt      420

gcagttagct ctgagggagc attgttctgt tctgtgggtg atgataaagc aatgaaggtg      480

tttgatgtag tgaactttga catgatcaac atgctgaaac ttggctattt tcctggacag      540

tgtgagtgga tctattgccc aggggatgca atttcttcag ttgctgcttc cgaaaagagt      600

acaggaaaaa ttttcattta tgatggccga ggagataacc agccacttca tatttttgac      660

aaactccata catcacctct tactcagata cggctaaacc cagtttacaa agcagtagtg      720

tcttctgaca aatctgggat gattgaatac tggactgggc ctcctcatga atataaattc      780

cccaaaaatg tgaactggga atataaaact gacactgatt tatatgaatt tgccaagtgt      840

aaggcttatc caaccagcgt atgtttttca ccagatggga agaaaatagc tactattggt      900

tctgatagaa aagttagaat tttcagattt gtaactggaa aactcatgag agtctttgat      960

gaatcactaa gcatgtttac tgaactgcaa cagatgaggc aacagttacc agacatggaa     1020

tttggccgac gaatggctgt agaacgtgag ttggagaagg ttgatgctgt aagattaatt     1080

aatatagttt ttgatgaaac tggacacttc gtgctgtatg gaacaatgct gggcattaaa     1140

gttataaatg tagagacaaa ccggtgtgtg cggattttag gcaaacaaga aaatattaga     1200

gtgatgcaat tggctttgtt ccaggggata gccaaaaagc atcgtgctgc aactactata     1260

gaaatgaaag cttctgaaaa tcctgttctt cagaatattc aagctgaccc aacaatagtc     1320

tgtacatcat tcaaaaagaa tagattttat atgtttacca aacgagaacc agaagatacg     1380

aaaagtgcag attctgatcg agatgttttt aatgagaaac cttctaaaga agaagtcatg     1440

gcagctactc aagctgaagg acctaaacga gtttcggaca gtgccattat ccacaccagc     1500

atgggagaca ttcacaccaa actttttcct gttgagtgcc ctaagacagt ggaaaacttc     1560

tgtgttcaca gcagaaatgg ttattataat gggcatacat ttcaccgtat aattaagggc     1620

tttatgattc agactggaga tccaacaggt actggtatgg gaggagaaag catatgggga     1680

ggagaatttg aagatgaatt tcattcaaca ttacgacatg acaggccgta cacactcagc     1740

atggctaacg cgggatcaaa tactaatgga tcccagtttt tcataacggt agtaccaacg     1800

ccttggcttg ataataagca tacagtattt ggacgagtga ctaaaggaat ggaagttgta     1860

cagaggatct ccaacgtcaa agtcaatccc aaaacagata agccctatga ggatgtcagc     1920

atcataaata ttactgtcaa gtaaaataag atttgtttta atgtacttgc aaataaaaat     1980

acaatattaa acagattatt ttacattagg aagcttagga cttgctgaat atacagatca     2040

tgtttcaaag atacagtatt tttgtatttt ttattaaagg ctatttttta aaaaaaaaaa     2100

aaaaaaaaaa                                                            2110


<210>  65
<211>  1937
<212>  DNA
<213>  Homo sapiens

<400>  65
ggccgcagtt tctggaggga gccgctgcgg gtctttccct cactcgtcct ccgcgcgtcg       60

ccgctcttcg gttctgctct gtccgccgcc atggcccaag ctgacatcgc gctgatcgga      120

ttggccgtca tgggccagaa cttaattctg aacatgaatg accacggctt tgtggtctgt      180

gcttttaata ggactgtctc caaagttgat gatttcttgg ccaatgaggc aaagggaacc      240

aaagtggtgg gtgcccagtc cctgaaagag atggtctcca agctgaagaa gccccggcgg      300

atcatcctcc tggtgaaggc tgggcaagct gtggatgatt tcatcgagaa attggtacca      360

ttgttggata ctggtgacat catcattgac ggaggaaatt ctgaatatag ggacaccaca      420

agacggtgcc gagacctcaa ggccaaggga attttatttg tggggagcgg agtcagtggt      480

ggagaggaag gggcccggta tggcccatcg ctcatgccag gagggaacaa agaagcgtgg      540

ccccacatca agaccatctt ccaaggcatt gctgcaaaag tgggaactgg agaaccctgc      600

tgtgactggg tgggagatga gggagcaggc cacttcgtga agatggtgca caacgggata      660

gagtatgggg acatgcagct gatctgtgag gcataccacc tgatgaaaga cgtgctgggc      720

atggcgcagg acgagatggc ccaggccttt gaggattgga ataagacaga gctagactca      780

ttcctgattg aaatcacagc caatattctc aagttccaag acaccgatgg caaacacctg      840

ctgccaaaga tcagggacag cgcggggcag aagggcacag ggaagtggac cgccatctcc      900

gccctggaat acggcgtacc cgtcaccctc attggagaag ctgtctttgc tcggtgctta      960

tcatctctga aggatgagag aattcaagct agcaaaaagc tgaagggtcc ccagaagttc     1020

cagtttgatg gtgataagaa atcattcctg gaggacattc ggaaggcact ctacgcttcc     1080

aagatcatct cttacgctca aggctttatg ctgctaaggc aggcagccac cgagtttggc     1140

tggactctca attatggtgg catcgccctg atgtggagag ggggctgcat cattagaagt     1200

gtattcctag gaaagataaa ggatgcattt gatcgaaacc cggaacttca gaacctccta     1260

ctggacgact tctttaagtc agctgttgaa aactgccagg actcctggcg gcgggcagtc     1320

agcactgggg tccaggctgg cattcccatg ccctgtttta ccactgccct ctccttctat     1380

gacgggtaca gacatgagat gcttccagcc agcctcatcc aggctcagcg ggattacttc     1440

ggggctcaca cctatgaact cttggccaaa ccagggcagt ttatccacac caactggaca     1500

ggccatggtg gcaccgtgtc atcctcgtca tacaatgcct gatcatgctg ctcctgtcac     1560

cctccacgat tccacagacc aggacattcc atgtgcctca tggcactgcc acctggccct     1620

ttgccctatt ttctgttcag ttttttaaaa gtgttgtaag agactcctga ggaagacaca     1680

cagtttattt gtaaagtagc tctgtgagag ccaccatgcc ctctgccctt gcctcttggg     1740

actgaccagg agctgctcat gtgcgtgaga gtgggaacca tctccttgcg gcagtggctt     1800

ccgcgtgccc cgtgtgctgg tgcggttccc atcacgcaga caggaagggt gtttgcgcac     1860

tctgatcaac tggaacctct gtatcatgcg gctgaattcc ctttttcctt tactcaataa     1920

aagctacatc acactga                                                    1937


<210>  66
<211>  1368
<212>  DNA
<213>  Homo sapiens

<400>  66
cgctgtgacc tagaatgggc gcatgcgccg agcggaactg gctggtttga aaaccatggc       60

gtgggtacca gcggagtccg cagtggaaga gttgatgcct cggctattgc cggtagagcc      120

ttgcgacttg acggaaggtt tcgatccctc ggtacccccg aggacgcctc aggaatacct      180

gaggcgggtc cagatcgaag cagctcaatg tccagatgtt gtggtagctc aaattgaccc      240

aaagaagttg aaaaggaagc aaagtgtgaa tatttctctt tcaggatgcc aacccgcccc      300

tgaaggttat tccccaacac ttcaatggca acagcaacaa gtggcacagt tttcaactgt      360

tcgacagaat gtgaacaaac atagaagtca ctggaaatca caacagttgg atagtaatgt      420

gacaatgcca aaatctgaag atgaagaagg ctggaagaaa ttttgtctgg gtgaaaagtt      480

atgtgctgac ggggctgttg gaccagccac aaatgaaagt cctggaatag attatgtaca      540

aattggtttt cctcccttgc ttagtattgt tagcagaatg aatcaggcaa cagtaactag      600

tgtcttggaa tatctgagta attggtttgg agaaagagac tttactccag aattgggaag      660

atggctttat gctttattgg cttgtcttga aaagcctttg ttacctgagg ctcattcact      720

gattcggcag cttgcaagaa ggtgctctga agtgaggctc ttagtggata gcaaagatga      780

tgagagggtt cctgctttga atttattaat ctgcttggtt agcaggtatt ttgaccaacg      840

tgatttagct gatgagccat cttgatgtag ctgatctctc agggatagaa gatatttctc      900

atgaaggcag cctaactctg aggaaaacaa tgccaattca agtacagatt tcaacacatc      960

ttcaacacta tgtgaagggt tcacatctta acctgtgcaa ttcagattga tactcagaat     1020

atgggttgat ttgaatatct gaaatatcaa tggaaaatcc cactcagttt ttgatgaaca     1080

gtttgaacag ttttctgtaa tcaagcagct tgcatagaaa ttgtatgatg aaattttaca     1140

taggttcttg gtgctgtttt gttctttttt tgttttttgt tgttttgtta tttacttata     1200

tacatataaa attttattga aaatatgttt tggttactaa aattttgttt gactcctaac     1260

aaaagacaat ggatggcctt agcatcagaa ttaaaataat ctggattaaa tggcaatgtg     1320

ttcatagtca gcaataaaat taaacatttt tccctttaaa aaaaaaaa                  1368


<210>  67
<211>  2647
<212>  DNA
<213>  Homo sapiens

<400>  67
gcaacttcct ggtggaaaac cgcgactctt gcaagtgggc aaacttgacg ttttcgctat       60

gggcaaacgc gggagccgga gccagagcca gctactcaac accctaacta aaaagcagaa      120

gaaacatctt cgagatttcg gcgaggagca tcccttctat gacagggttt ccagaaagga      180

agcaaagcca cagatttgtc agctgtcaga gagttcagat tcttcagatt ctgaaagcga      240

ctcagagagt gaaccacaac aagtttctgg ctaccacaga ctacttgcta cattaaagaa      300

tgtttctgag gaagaagagg aagatgagga ggaggaagag gaagaagaca gtattgtaga      360

tgatgcagaa atgaacgatg aagatggtgg tagcgatgtc agtgtggaag aagagatggc      420

tgcagagtct actgaaagtc cagagaatgt agctttatct gctgaccctg agggaaaaga      480

agatggggaa gagccaccgg gcacatcaca aacatccccc gaagagttca cagatgcaaa      540

acacgagtca ctgttcagcc tggaaaccaa ttttctggaa gaggaaagtg gagacaactc      600

ttctttgaaa gcctctcaag atccatttct tcaacatgtg aacaaagaac tgaaagaaaa      660

agcaattcag gctgttgcca caaatcccaa aactacccac gagcttaaat ggcctattct      720

gggccagctt ttcttttcct ctaagtttca gaagttggaa acatttaaac ccccaaagga      780

tattgactta aagtcacttc atctccagaa gcctctggaa tccacctgga ctaagaccaa      840

cagccagttc ctatctggtc cccaaaaatc aagcagccca ttcacccccc tccagaaaga      900

actcttctta attatgaatt cttaccggga cctgttctac ccggaaagga ctgctctgaa      960

gaacggggaa gagatccgcc atgtgtattg cctgcatgtg ataaatcaca tcctcaaagc     1020

caatgcccag gtgcttggca acaatagcag acgccgaagc cagaagtttg gagtgggtga     1080

tgatgatgac ttcagagacc aagggttaac aaggcccaag gtactgatag tggtgccatt     1140

ccgggaagct gctttgcggg tggtgcagct cttcatcagc ctcctcgagg gtgacagcaa     1200

gaagaaaatc attgtgagca acaaaaagag gtttcaggga gaatatggat cagatcccga     1260

ggagagacca cccaacttga agaggcctga ggattatgaa gccgtatttg tgggcaatat     1320

tgatgaccac ttcaggattg gagtggcaat acttcagaga agcatccgac tctatgcccc     1380

gttttactcc tcggatatcc tcattgcttc ccccctgggc ttgaggacca tcattggtgg     1440

agaaggagag aagaagagag attttgactt tctgtcttct atcgagcttc tcatcattga     1500

tcaagctgac atttacctga tgcagaactg ggagcatgtc ctgcatttga tgaatcacat     1560

gaacctacta cccctggact cacatggggt agacttttct cgagtgcgga tgtggagcct     1620

caataattgg tccaagtact atcgccagac actgctattt ggggcccttc aggatgccca     1680

gatcaactca gtgttcaaca agtactgtgt caacatgcaa ggccaggtgg ccgtgaggaa     1740

tgtcccaatg acaggctcta tcagtcatgt cctggtgcag ctcccacatg tcttccagag     1800

gatggaagct gaaaacctag cttcagtgat tgatgccagg tttaactttt ttgtgaacaa     1860

gattttgcca cagtatcgtg atgcagtcat gtctcacacg ctcatctata tcccctccta     1920

ctttgacttc gtgcgtcttc gaaattactt caagaaggag gaattgaatt ttacccacat     1980

ctgcgagtac acgcagaagt ctggtgtctc cagggccaga cacttcttcc ttcaaggaga     2040

gaaacagttt ctacttttca cagagcgctt ccatttctac aaaaggtata caataaaagg     2100

catcaggaac ctgattttct atgaactgcc gacatatcca cacttttaca gtgaaatctg     2160

taatatgctg agagccacca acagaggaga agaggccacg tggacctgca ctgttctcta     2220

ctccaaatat gatgcccaga ggttagctgc cgtggttggt gtggagcggg cggcacagat     2280

gctacagtcc aacaagaatg tccacctctt cattactgga gaaaaatgaa attttgttgg     2340

gcaggaagtg gtatttggca tgatacataa tgtttgattc tatgccattt ggacccaatt     2400

ctgattactt acagaagaag gactgataca aagaaagtgc atgaggcaat gtcagtatta     2460

tctgacatct ttcttttcag gtcatgtgtc cctgaaaagt taaatgtaaa ccagattttg     2520

gtaaatccca tctttcagaa gtgaagaggg ggctagaagg actctgagaa gttggtagaa     2580

gaaaactccc acttgtgaat atttttgtga gacataaatt cttttattac gaaaaaaaaa     2640

aaaaaaa                                                               2647


<210>  68
<211>  5356
<212>  DNA
<213>  Homo sapiens

<400>  68
cgggattcgg ctggctctgc cacaccaccg cgcgcccccg ctccgcccgc ccctccgggc       60

gcgtcttttc cgggctcgcg ctgagtcccg cctccgccgg ctgtccgggt gcgcgcgcgc      120

cgctgcggct ttttctctgg cctccgccgc gcgctcctcc tcgtcccagc gctagcgggc      180

acgcggttcc tttttgcgag ctttccgagt gccaggcgcc ggccggctgc gaagacgcgg      240

tgggccgccc ctccgattga aatcacagaa gatattcgtg ttcttcttaa gagaaaaaga      300

ggacatttta gctttctcag ttgaaggcgt actttattgt cggcttccaa agattactaa      360

cttttatctg tatcactaag attgaactgc cttggctgta ctgctattct tactgctgct      420

tctattattg ccttcttcag cacaataagg ctttcaaaag ccaaagaata acaagaaata      480

agcaccattt tagaagcctt tccactatga aacttaagct aaatgtgctc accattattt      540

tgctgcctgt ccacttgtta ataacaatat acagtgccct tatatttatt ccatggtatt      600

ttcttaccaa tgccaagaag aaaaacgcta tggcaaagag aataaaagct aagcccactt      660

cagacaaacc tggaagtcca tatcgctctg tcacacactt cgactcacta gctgtaatag      720

acatccctgg agcagatact ctggataaat tatttgacca tgctgtatcc aagtttggga      780

agaaggacag ccttgggacc agggaaatcc taagtgaaga aaatgaaatg cagccaaatg      840

gaaaagtttt taagaagtta attcttggga attataaatg gatgaactat cttgaagtga      900

atcgcagagt gaataacttt ggtagtggac tcactgcact gggactaaaa ccaaagaaca      960

ccattgccat cttctgtgag accagggccg aatggatgat tgcagcacag acctgcttta     1020

agtacaactt tcctcttgtg actttatatg ccacacttgg caaagaagca gtagttcatg     1080

ggctaaatga atctgaggct tcctatctga ttaccagtgt tgaacttctg gaaagtaaac     1140

ttaagactgc attgttagat atcagttgtg ttaaacatat catttatgtg gacaataagg     1200

ctatcaataa agcagagtac cctgaaggat ttgagattca cagcatgcaa tcagtagaag     1260

agttgggatc taacccagaa aacttgggca ttcctccaag tagaccaacg ccttcagaca     1320

tggccattgt tatgtatact agtggttcta ctggccgacc taagggagtg atgatgcatc     1380

atagcaattt gatagctgga atgacaggcc agtgtgaaag aatacctgga ctgggaccga     1440

aggacacata tattggctac ttgcctttgg ctcatgtgct agaactgaca gcagagatat     1500

cttgctttac ctatggctgc aggattggat attcttctcc gcttacactc tctgaccagt     1560

ccagcaaaat taaaaaagga agcaaaggag actgtactgt actgaagccc acacttatgg     1620

ctgctgttcc ggaaatcatg gatagaattt ataagaatgt tatgagcaaa gtccaagaga     1680

tgaattatat tcagaaaact ctgttcaaga tagggtatga ttacaaattg gaacagatca     1740

aaaagggata tgatgcacct ctttgcaatc tgttactgtt taaaaaggtc aaggccctgc     1800

tgggagggaa tgtccgcatg atgctgtctg gaggggcccc gctatctcct cagacacacc     1860

gattcatgaa tgtctgcttc tgctgcccaa ttggccaggg ttatggactg acagaatcat     1920

gtggtgctgg gacagttact gaagtaactg actatactac tggcagagtt ggagcacctc     1980

ttatttgctg tgaaattaag ctaaaagact ggcaagaagg cggttataca attaatgaca     2040

agccaaaccc cagaggtgaa atcgtaattg gtggacagaa catctccatg ggatatttta     2100

aaaatgaaga gaaaacagca gaagattatt ctgtggatga aaatggacaa aggtggtttt     2160

gcactggtga tattggagaa ttccatcccg atggatgttt acagattata gatcgtaaga     2220

aagatctagt gaagttacaa gcaggagagt atgtatctct tgggaaagta gaagctgcac     2280

tgaagaattg tccacttatt gacaacatct gtgcttttgc caaaagtgat cagtcctatg     2340

tgatcagttt tgtggttcct aaccagaaaa ggttgacact tttggcacaa cagaaagggg     2400

tagaaggaac ttgggttgat atctgcaata atcctgctat ggaagctgaa atactgaaag     2460

aaattcgaga agctgcaaat gccatgaaat tggagcgatt tgaaattcca atcaaggttc     2520

gattaagccc agagccatgg acccctgaaa ctggtttggt aactgatgct ttcaaactga     2580

aaaggaagga gctgaggaac cattacctca aagacattga acgaatgtat gggggcaaat     2640

aaaatgttgt tgtcttattg acagttgtgc aggaggtagc ctggtggttt tcaacctcta     2700

gaattttaag cctttgttga actgttagaa tgtaaggtat atcattctaa agatagagta     2760

aaaagaaaac aaaaccaaaa gttattaaaa ttgttgtccg gtttacttta acttagtttt     2820

gcatagttct agtgcagctg aaattgaaaa gttatttccc tttagctgtg ttattataga     2880

gcagaaattc tgtttttaaa aattagccta agatatactt gtttttgtaa agaaaaatat     2940

ttaatgttga acaaaataaa ttggagttgg agtagaatgt agtttgagga aatttgcagc     3000

ttccaatgcc tcttgtcttc ctatttcaga agtttaaata ttaagcatga cagaaaatat     3060

gtattaacac tactcaaagc aaaagtgctg cagggcttta aaattctctt ccaaccattt     3120

atcttgaagg aaaaattcaa tagtaatata atacacaaaa tcaaataata ccttagaagg     3180

tattaagatt ataattgttg cataggttag atatagagtc attgtaatgt tgtgaataat     3240

tacagtgcct aaaataagaa tagaacaaca tatacaacac caaaaaatat ctagtaatat     3300

atttaaaggg aaattgagct gctttttttg aaactttgag atctaaaaat aactgtaatt     3360

atttgaatga ctaagaggaa agtacatttt ttgaaatgct gaaaattgcc tttctgtgtt     3420

tattcaaact gaaaagctga gaccaagagc aaggaaggta aaaagttaac aggcaaacat     3480

tttctcttag aaaaggtgat aaaatcataa gtatttggaa ttagaaccct tgcacagcac     3540

tgaacctggg aaagagattt aaactctgaa tttatctttg ataacaggga ttgattttaa     3600

aatgtacatg tattaaatta catttgtaat ttaaggtctg tttgctgttg ctgattttat     3660

tcttgatcag tagtttgcat ttcagaaagc ctttcatttt gctttaagtt tagcaaagcg     3720

gggttataat gaatgacttc cccaatatct tgcttgaact tacagtgatt aacttggatg     3780

agttttggga agttaaaggg aagaaaacac tgttatcatt ttttcctgtt tgggaagagc     3840

ttagaaactg gaaatactag atttgggaga agggcagagt tacttgataa gggacttgat     3900

gtttgtgcag taacttggga gtgtggtttc tttttgaatc tttaattaaa acctgggatt     3960

atatatccct gataaatatt cacacttgaa ccatagttac tgtaaaatgc aaaaaatctt     4020

aatactgtta ttctttgcac tttttcttaa tcatttttta tatatatgca tatatatatg     4080

tgtgtgtgtg tgttgcttat gttgttttgt acagatgtgg gccaccattg caacaaaata     4140

cattcttttt gctctaaaat atttatgaag aaaatactta aatgttatgt atatggtggt     4200

aataagggaa aaatcaagta ttataaacaa gaatgaaggt ttttgtaaag atttctgttc     4260

agcgttttgc aaggtaaaat tttaggcaag ttttccctga agttatgtgt atgtgagtat     4320

tctcattctt cccaacttgc ctttgaagag tgaaatacca ttattatcaa gtagactact     4380

gttcagcttt tattccttcc ctggttgttt atcccttagg aatgagtttc ttagactttc     4440

ccaatatgtg attttttttc ccatttagaa tggtgatttt aaatgtgtga gtgcatgtac     4500

tatcttatct cagatatttg cacccccaat ctgcccccaa ctcccaaaag ctagaacact     4560

gccaactgat ctgttatagg tcctttagaa acacataatt aacacttaag gttgggtgct     4620

gctaattctt tgcaaaaatc caaatattgt taagggacca gggagatgcc actacccctt     4680

gattttccat ctaaaaatat acatgtttat gtaaacaaat ctttccatat ccatagtgac     4740

ttttcaagta tttaagccta aagattttga tctcacattt ttatacctgt ttaaattgct     4800

cacagttatt acatacacat cagccatcaa ctaaagttgt actttaaaaa tttactacaa     4860

tatgtacatt tctaagtcaa acacttgtga cttttgcttt aattccatga atgttcctgc     4920

ctccttgata tttgtattta ttcttttttt ctctagagta gaggtataat tgtgtgatat     4980

ttcagaaata cagataaatg attcaaaaag tcacagttaa ggagaatcat gtttctttga     5040

tcatgaataa ctgattagta agtcttgcct atattttcct gatagcatat gacaaatgtt     5100

tctaaggtaa caagatgaga acagataaag attgtgtggt gttttggatt tggagagaaa     5160

tattttaatt tttaaatgca gttacaaatt ataatgtatt catatttgta ctttctgtta     5220

aaatgcatga ttgcagaatt gtttagattt tgtgtttatt cttgatgaaa agctttgttt     5280

gttcttgttt ttaagtttgc actcaaatct taagaaataa atccacccat gttatcaaaa     5340

aaaaaaaaaa aaaaaa                                                     5356


<210>  69
<211>  9122
<212>  DNA
<213>  Homo sapiens

<400>  69
cacaaggcaa agcctgctct ctctgtctct ctgtctcctc ttctcctttt ttgccttatt       60

ctatccgatt ttttccctaa gcttctacct gggattttcc tttggaaaag tctctgaggt      120

tccaccaaaa tatggaactt gattttggac actttgacga aagagataag acatccagga      180

acatgcgagg ctcccggatg aatgggttgc ctagccccac tcacagcgcc cactgtagct      240

tctaccgaac cagaaccttg caggcactga gtaatgagaa gaaagccaag aaggtacgtt      300

tctaccgcaa tggggaccgc tacttcaagg ggattgtgta cgctgtgtcc tctgaccgtt      360

ttcgcagctt tgacgccttg ctggctgacc tgacgcgatc tctgtctgac aacatcaacc      420

tgcctcaggg agtgcgttac atttacacca ttgatggatc caggaagatc ggaagcatgg      480

atgaactgga ggaaggggaa agctatgtct gttcctcaga caacttcttt aaaaaggtgg      540

agtacaccaa gaatgtcaat cccaactggt ctgtcaacgt aaaaacatct gccaatatga      600

aagcccccca gtccttggct agcagcaaca gtgcacaggc cagggagaac aaggactttg      660

tgcgccccaa gctggttacc atcatccgca gtggggtgaa gcctcggaag gctgtgcgtg      720

tgcttctgaa caagaagaca gcccactctt ttgagcaagt cctcactgat atcacagaag      780

ccatcaaact ggagaccggg gttgtcaaaa aactctacac tctggatgga aaacaggtaa      840

cttgtctcca tgatttcttt ggtgatgatg atgtgtttat tgcctgtggt cctgaaaaat      900

ttcgctatgc tcaggatgat ttttctctgg atgaaaatga atgccgagtc atgaagggaa      960

acccatcagc cacagctggc ccaaaggcat ccccaacacc tcagaagact tcagccaaga     1020

gccctggtcc tatgcgccga agcaagtctc cagctgactc agcaaacgga acctccagca     1080

gccagctctc tacccccaag tctaagcagt ctcccatctc tacgcccacc agtcctggca     1140

gcctccggaa gcacaaggac ctgtacctgc ctctgtcctt ggatgactcg gactcgcttg     1200

gtgattccat gtaaaggagg ggagagtgct cagagtccag agtacaaatc caagcctatc     1260

attgtagtag ggtacttctg ctcaagtgtc caacagggct attggtgctt tcaagttttt     1320

attttgttgt tgttgttatt ttgaaaaaca cattgtaata tgttgggttt attttcctgt     1380

gatttctcct ctgggccact gatccacagt taccaattat gagagataga ttgataacca     1440

tcctttgggg cagcattcca gggatgcaaa atgtgctagt ccatgacctt tcaatggaaa     1500

gcttaggtgc ctgcgttata tttgccctgt ctaattttgc ccatacagtc ttccttctgt     1560

agagggctgt ttacatatac agcacttaaa atgtttgtgt gggaaaaaaa aaactcattg     1620

gcagatccaa gaatgacaaa cacaagtgcc ccttttctct ggatctcaag aatggtggag     1680

gaccctggaa ggacagcaag gcagctcccc agcctcactc ttcactcctg attgaggccc     1740

gggtttgttg tccagcacca attctggctg tcaatgggga gaaataaacc aacaacttat     1800

aattgtgaca ccagatgctt aggatcctgg tgctgggtta gctaagagaa tagacagaat     1860

tggaaaatac tgcagacatt tccgaagagt ttataaagca cagtgaattc ctggtcaatc     1920

tctccactga ggcaatttgg aatcaataag caattgataa tagtttggag taagggactt     1980

catatacctg attcctctag aaggctgtct aacataccac atgattacat gaactgtatg     2040

gtatccatct atctctgttc tattgaatgc cttgttaaca gccaacactg aaaacactgt     2100

gagaatttgt tttcaggtct gacacctttc agtctctttt tatagcaaga aatcaatatc     2160

ctttttataa aaattcatgt ctgtatttca ggagcaaact cttcaggctc cttttttata     2220

aactggtgat ttttcttttg tctaaaaaac acatgaagaa aatttaccaa aaaaaaaaaa     2280

aaaagcagaa gaataatgta gtttagaaat tatgctgtca ctgccaaaca gtaacctcca     2340

ggagaaaaca agatgaatag cagaggccaa ttcaatagaa tcagtttttt gatagctttt     2400

taacagttat gcttgcatta ataatttcaa tgtggaccag acattctaat tatattttaa     2460

atgaaatgtt acagcatatt ttaagcaact ctttttatct ataatcctaa tatttcatac     2520

tgaagacaca gaaatctttc acttgtcttt aacattagaa aggatttctc tttactaagg     2580

actgatcatt tgaaatagtt ttcagtcttt tgagatacag gtttataaca ctgctttttt     2640

ttttctgtaa tcatagccca taatggcaaa gacaactaaa tttaagtgaa ggtcatgcat     2700

gccaattctg tgtttgcttt tagcagatat gaagatttcc ttatttcttt gtaattgtgc     2760

agatattttg aaaggcacag cattcgaagc caagctgctg tttggctact gaatggcttg     2820

cagttgttcc tccactctaa atggaatgag cttgctgtgt gtgtgtgtgg tggtggtggg     2880

agggggtggt gcatgtgtgt gtgtgtgtgt gcatctgcag ctgcttcaaa attaggaaat     2940

actacaggac acccctgtaa tggattggtg gcaactgggt ggcactgctg atgtgcactg     3000

tgtagggggg aacccagtgg tggtggggta gctcagatgc ccctagacaa gcttcagatg     3060

tctgtagcta ccagaaacat tttcggttca ggaaaagtga gatgatggta gtactggttt     3120

ctggtgaaat tgaagaaccc caaatgatga ggatctcttt ttgccccctc tccttttttt     3180

gtagacccat tcaaaaccat taataagccc attttactaa gcccctattt ctttctagaa     3240

gctcagggtt ttcttagtgc ctcccagaac attttgtagt taattgggaa aaagtgatac     3300

ttggattagg gggtgtgggc ataaagaatg gtgggaggcc tgattttaaa cttcaggcca     3360

gaacccccaa tgactccacc catagtctca ctttaggtct catttagtcc atcaccttta     3420

ttttaagttg aggaagtgga ggctggtaaa gagcaggacc agaggaagaa tccagatttc     3480

cttatgcttg ggcctcacac tagctctctg agtatttcct tgattgcggt atatgtacta     3540

ctagaaaata ccaaatggat atattttctt taggataacc tttgaaccaa caatcttcaa     3600

taacaatagt acatcttcca tcttactttt aatcgagtat aaggaaatgt ttctttatgg     3660

ccattttgga gggagcaggg gatgaggctt ggcatagtcc aaaatttaag tctccaataa     3720

ttaattgcat tttaaattgg cccactttca aggcaatttt ttttgtgtgt ctgtaactga     3780

gctcctccac ccctgtcatt cacttccaat tttacccaat ccaattttag cactcaagtt     3840

ccattgtgtt aatttctgca cggtcaacaa acatcaagtc agcaagcatt tgccaccact     3900

ccctatactt ctccctcctt cttacacaca cacacacaca cacacacaca atccatctct     3960

tgcttgttcc tacctcctga tttttcttcc ctacagaaat agaaataggg acaaagaagg     4020

ggaaaatgta tatattgggg ctgggctgaa caactaactt cataagtagt attaactagg     4080

ggtaaattga gagaaaagct ccttttctct tcactgtttt ggaaaggata gccattagca     4140

tgactgcttt gtgtccttat ggactttagt attagcctag attgaattat agcgttttct     4200

agctggaagg aaccttaaga tcacatcatc tactcctcta ctccaaattt ctcattcttc     4260

aggccaggaa accgagacac agaggtaaag taatttcccc aaggtcacac agctggctgg     4320

ggcaggattg ggtttacaac ccacatctcc tggctcttat tccagggcct tttcccacta     4380

agtagtattg ccttccatta ggctcctgag agttatttct cagggtcatg ttgcatcttg     4440

gagccacatg ctgctgccct gatctcagtg ggaaatccac ccagcaacct aatacagccc     4500

cttttccctg cattcacctg gttcccatcc acatgggttg cagatgtcct tgaagagagt     4560

gaggcattga gggccaatag gagcaatggg gtccctggcc ttgtccatct gattcaggag     4620

atcactgctc catcgtgagg agccctctga atagcccccc actgaatgct tgccttgccc     4680

aaatggaatg gaggaagatt gattttctcc atcagttcac cttgtgtcat ctcataatgg     4740

ttggtctttc caggctgagg gaaatgtttc ttgtttccag agtagaaaaa gaaagagtgg     4800

aacaatagct ttgttcatcc taactttctg agatggcttt tcaacatttt aaaaaaacta     4860

gtgtggctac cattcactgg caatgatttc ttttagaata tgggagtaag atgagctaga     4920

gaaaataacc tggtctcact gtggttgccc tcatccacaa tgtccccaaa gccatcctgc     4980

tctgatgagg acaatttcca ggtataagca aggggctttg tgacaaaaat gtaccctggc     5040

tgatgttaaa cattggctcc tgtgtttgca ccaaaatagc aagctgtgtg ctctatacac     5100

tcttcccatc gtcttgtgta cactgctcct gtggccttcc acagcagaaa ccagggcaaa     5160

agggtccaaa cacatggttt tccttgctgc aaggctcttc ctgggaacta agggggtatt     5220

tattagttca gttctaagag acctccttct gggcttaccc cactcctcag gtacttctct     5280

ctccttcctc cttctcctcc acagtcacaa gtaaccaagg aacctgaaag tggatgtgta     5340

gctatttgaa gaaggcaagg aaccctgaga ttcttctttg aatcctctag tccaagtctt     5400

agaccagtga ttggtgctta ccttgaacaa aattttgtct gtgttcctaa tcccttcaat     5460

actctgggta caatgctccc aatcaccctg cacatttgat tctaaatggc ttttattttt     5520

taaaaatcca tatccctagg acaagagaac aggatgccta tatccccaaa atgagctcca     5580

ggacactgat gggaatgatc ccaaagatca ccccacctca gaaacgtctg tgccaagaga     5640

cttccccaga tagaaacact gggacagtgg tttgaacgac ttcttttatg gttgtccagt     5700

ttgctatgga aataaaaggc attgattttt taaaaagatg attggaacct gtctttggcc     5760

acatagggcc acttggatcc atttccaggc cttactcata tattgccttc actgaagggc     5820

tttggcttta agtcccagac tggtctccca agtgaaccat aagtgttttg gagctcatct     5880

ggggtgaggc atgagaatgt tgccccatct atcccttcag gaaaaggtgc cttccctccc     5940

tttctcctaa agcctggtcc ccagaaattg tttttgtctc caaaagtcta gtatggtctt     6000

tatacaccca gactcttagt gttgcgtcct gccttgtttc cttgttaagg atctatgcag     6060

acctcccgct ttggcttagc tagcgtgaca ttggctatca tttgacaaga ctaacttttt     6120

tttttttttt tttttgactg agtctccctc tgtcacctag gctggagtgc agtggcacaa     6180

tcttggctcg ctgcaacctt cacccttcac ctcccaggtc gaagcgattc tcctgcctca     6240

gtctcccgag tagctgggat tacaggcgtg cgccaccaaa tctggctatt tttttattat     6300

tattattttt agtagagatg gggtttcacc atgttggcca gactggtctt gaactcttgg     6360

cctcaaatta tctgcccacc tcggcctccc aaagtgctgg gattacaggc atgagccacc     6420

atgcccagct gacaagacta attttttatc ccttggttta ttggcttcaa catcttctgg     6480

aatcagaggt gattttttct taccttggat gcctgagact aggggagtat agaattccaa     6540

ttggtaatta aggcatcttt ctgctcctga tcagaagggc aggttagttg ggagaggtca     6600

gatggcacaa cagaagtcac cttgtaagta aggcaaagac ttgaaggcat tagcgtttct     6660

cattactagg tcaataacct gagggaatca atggcttttt gccgctctac ctcttgtgta     6720

tctctttgac ttttctttct ctgtctagtt tcctctgttc tcagtttata ttctatgtta     6780

tcagtctctc tttccacagt acaaacatcc atcctttctc ctgtgcaatt ctgtctctcc     6840

ctcttattat ctttatttgt actttttcct tcctccctgt ctaggcattg ggcatgtgcc     6900

tcttcttagc ctgtgatttt gccttgggac tgatgataaa ttatttccag attcaatcag     6960

ccctggtcct accccagtcc aatcagaagt atgttggtgg gaatcaacct gatcctggcc     7020

ctttcttctt ctccattttc attcgtaatc cccctcagca gatctttaca agcagtttcc     7080

ttatagctca tgtatcttta ggtctttgcc ttccaagcac tgtacagaat actttgtggt     7140

tcctttttag tctgacattt tgtggagcag tgaagcgtgc tcagagacat aatcagctga     7200

agagaaaaaa tccacccatg gatttatatc agctaaatac taataattga ttttgtttga     7260

tgtgcccata atttttaaag ctgcaatata atataatgag ggaccacagg taatttctcc     7320

tgtcatttgt tttggctgga tgggggtggg ggagtaattg cttaaagttt taccattaca     7380

cattaaactc tctataataa tcttgtttgg ggcttgctaa ctgttgagct gttttaacta     7440

aactggtagg caatcggagt tgatttaaat gaaaagataa tttaacaaat ctatactata     7500

aaaagagaca tttgcttaat tgacatgtat tttttccttc tgagtcacct aaacatttac     7560

tcttgacacc aactgttcat gatactgaat agacagtcca tataagagaa attagtggac     7620

ctaaagaagc cagattgtag gtgttaattt attaaacaga gtgcaaagcc cttggaaatg     7680

tcactgcttg gcaataccat atggaatgcc aaaatttaca atgacttttc tttataagtt     7740

atccaaaagg gatttgaaca agtaagaggt tatgccaaaa tgtctccaat gtatggtcct     7800

gtaatatatt gcagcttgaa gccaatgatc ccttatgact tgtatacaac taatgcatgt     7860

tttattgaat tttgcatttc ccacgtgtgg taagttcttt aaaatgtttt tgatcacctt     7920

tttgtgccat taaacttgta cagaaaatgt ttttatggcc attttcaaag ggagaaagtt     7980

taaaatggaa acagcccacc ctttctgccc tatagctgta gttagaattg agtacctgta     8040

gcaaaacagc tgtaattggt ggttgtagtg ttagaggtgt tagcttgcta gtgactagct     8100

ttggagagta aatgcatggt attgtacatc acatttctta actcgtttta acctctgaaa     8160

agaatatatt cttctttgta gtccttcttc ccaccccctt gccctctccc tctccctgct     8220

cccagttgtc ttacagttgt aaatatctga tttgaggccc aataactctt gccaagtaaa     8280

gtcagcaaac aacaaacaaa ccaaaatgtg gggaaaaggc atttctcaac catctctcag     8340

cagttattga tcatttctta aggaacagca ttgtgatcaa agactcaact ttacgtaaaa     8400

atcagtggta aattggggtt gtatttggcc atttgattac atttcaggat tgaatagttt     8460

tcagaatcac atgtaatcca aagacagtag gtagtgatgt cccttatccc tgcagctgtt     8520

ttaagataga gacctcagaa gactctgctt gaccgatgac caataattat ttgaaaaaaa     8580

aagaaaaaat gagagaaata aaacagatat ttaagaactt tagccaccta tttagaatag     8640

ttatagccag aaaaaaaaac aagggcatga gttcaaatgc attactatca gtgtcctagg     8700

caatacctaa cctactctga aattgtgatt caaaagcagt atttcaagag gcattctcct     8760

tttttggttt gctgacccca cttggactgg taggtttggt gaggccccca taaaccagct     8820

ggagcagacc cttttcatct cctgtgcctg taacacccct cttcccccac cccctccgca     8880

attcaatgag ggctttcttg ggtcagagga cttcaaggtt gtctagagaa gtttgccatg     8940

tgtgtaaggt gctgtgaact gtgagtgctg aagattcgca gcattcaata ccaggcagcc     9000

aaagagctgc tcttgcaatt attttggctc tcaagctctg ttcttcatcg cattctcatt     9060

tctgtgtaca tttgcaagat gtgtgtaatg tcattttcca aaaataaaat ttgatttcaa     9120

ta                                                                    9122


<210>  70
<211>  2373
<212>  DNA
<213>  Homo sapiens

<400>  70
gtggttgggg aggggggggt ggggggactc tagacagctg aggcgcgaaa gcgatgagtc       60

ctcggctctt cctcctcctt ctccgggacc cgctctctgc ctccctctcc aacgcccgga      120

tgatctgagc cgcgagggcg ccgacagccg ggggcccgga cgcagcccgg ctcctcccct      180

cctccgcccc ttccccagcc tgacctggcc cgccgctgca gcggtgaccc ctcccccggc      240

tgccgccgtc gccgccgcgg tgaccccctc cccggctgcc gccgccgccg cctcggccga      300

ccagggacct gcccgcctgc ggctgctccg gattttaaat aaacttggag ccttttcttg      360

aaagacagct ggctgtggag agccttctac caactgcagt tttagatacg ttttgaaaat      420

ttcatcacct gagacctaga ggatcaagac ataatgggag catttttaga caagccaaag      480

atggaaaagc ataatgccca ggggcagggt aatgggttgc gatatgggct aagcagcatg      540

caaggctggc gtgttgaaat ggaggatgca catacggctg tgatcggttt gccaagtgga      600

cttgaatcgt ggtcattctt tgctgtgtat gatgggcatg ctggttctca ggttgccaaa      660

tactgctgtg agcatttgtt agatcacatc accaataacc aggattttaa agggtctgca      720

ggagcacctt ctgtggaaaa tgtaaagaat ggaatcagaa caggttttct ggagattgat      780

gaacacatga gagttatgtc agagaagaaa catggtgcag atagaagtgg gtcaacagct      840

gtaggtgtct taatttctcc ccaacatact tatttcatta actgtggaga ctcaagaggt      900

ttactttgta ggaacaggaa agttcatttc ttcacacaag atcacaaacc aagtaatccg      960

ctggagaaag aacgaattca gaatgcaggt ggctctgtaa tgattcagcg tgtgaatggc     1020

tctctggctg tatcgagggc ccttggggat tttgattaca aatgtgtcca tggaaaaggt     1080

cctactgagc agcttgtctc accagagcct gaagtccatg atattgaaag atctgaagaa     1140

gatgatcagt tcattatcct tgcatgtgat ggtatctggg atgttatggg aaatgaagag     1200

ctctgtgatt ttgtaagatc cagacttgaa gtcactgatg accttgagaa agtttgcaat     1260

gaagtagtcg acacctgttt gtataaggga agtcgagaca acatgagtgt gattttgatc     1320

tgttttccaa atgcacccaa agtatcgcca gaagcagtga agaaggaggc agagttggac     1380

aagtacctgg aatgcagagt agaaggtgga tcatttaaca aaaaataagt agctttatta     1440

aagaaaaatc ttcaacacaa tcaaacttta acattttagc ttttagattt ttatgtgtct     1500

ttgacagcta gtgtctagtg tatgaaagtg gaaaaggaca tttctgtagt agctgttaag     1560

atgtatgcag ttgtcctatc acagttatat tagaaataac aactagtgtg gaaagtaacc     1620

cacattctgt tcaggatact tttgttttaa aaggctaaaa tgtttgtgtg ctttaaaatt     1680

cttaatgaat tcactggcat gagtaatttt atgccgggaa aatctgattt gtggtctatt     1740

taattacaaa gagattgtga tggtgataat ttgaatacca tctttctatg aaaagctgtg     1800

tatattaatt ttaatctcta gggccttttt tcaataactt gaaaatcaca gcctcatcat     1860

tagcaacttt atatacacag ctttaaaaaa tttgctttaa actgtttcag agcttcttcc     1920

ctaagccata aactgtctca cctaaacaag atagacctca ataaaagaca taatatttct     1980

ccacctggca gaaaagtaac tgccaagtaa gattaagaaa taagttgagc atttctggag     2040

tatatttctc ataattctgc agagacttcc agtttattgc atatatgcag taaagtgtat     2100

atattatgca gtttctctaa gtggaaaaac ttgacatgac tttaatagtg ttaaaacatg     2160

aaaatgctgg tgagctgagg tagaaaaaaa acaagaaaaa aattttaaaa atagcgttaa     2220

aatgcatttt aggctcctaa tgtcgttaat ttgcacgtta aagacctcta atcgcatgca     2280

agcattgacc taccacacct acatcccact gtgcctgcat tattgaaatt actactcact     2340

ttaatttttt ttcccctttt tactgtttga tac                                  2373


<210>  71
<211>  3263
<212>  DNA
<213>  Homo sapiens

<400>  71
ccagaaacag acctgggagt ggaacagcag cagttaggag aggaccctgc tggggtccag       60

gagcccgcct gcctggctgc ccaaccagct ccaacactgc tggaggcctc cattctctgt      120

tcaggggaag gcccactggt tagctcagag atggcttctg cgtgctttct cccttccgtc      180

ctagagaaca catattttct gtttcctccc ttgccttctc ccacttggac ctgctcagag      240

ccctgtgtac tctggtgtgt ggcctctctc ccctctctct tttcctcctt ctggattctt      300

tcctatcttc atccacaatc tctacccttt atcttgccgt tactctaccc cgagactgcc      360

ttctgccctg ggtcccacca aatagatcct gtccttccct tagtgaaaat gaggccacct      420

cttggggaac agaagacgcc ccagtgaaaa cagagtgcaa acctggcctg gcatgggagc      480

ctccttctgg ccaatcaggc aggccagaga acagcagcgg agggccctgt ctttcaggca      540

gacctcatgg ctgagtgagc ctcccctggg cccagcaccc cacctcagca tggtccaagc      600

ccatgggggg cgctccagag cacagccgtt gaccttgtct ttgggggcag ccatgaccca      660

gcctccgcct gaaaaaacgc cagccaagaa gcatgtgcga ctgcaggaga ggcggggctc      720

caatgtggct ctgatgctgg acgttcggtc cctgggggcc gtagaaccca tctgctctgt      780

gaacacaccc cgggaggtca ccctacactt tctgcgcact gctggacacc cccttacccg      840

ctgggccctt cagcgccagc cacccagccc caagcaactg gaagaagaat tcttgaagat      900

cccttcaaac tttgtcagcc ccgaagacct ggacatccct ggccacgcct ccaaggaccg      960

atacaagacc atcttgccaa atccccagag ccgtgtctgt ctaggccggg cacagagcca     1020

ggaggacgga gattacatca atgccaacta catccgaggc tatgacggga aggagaaggt     1080

ctacattgcc acccagggcc ccatgcccaa cactgtgtcg gacttctggg agatggtgtg     1140

gcaagaggaa gtgtccctca ttgtcatgct cactcagctc cgagagggca aggagaaatg     1200

tgtccactac tggcccacag aagaggaaac ctatggaccc ttccagatcc gcatccagga     1260

catgaaagag tgcccagaat acactgtgcg gcagctcacc atccagtacc aggaagagcg     1320

ccggtcagta aagcacatcc tcttttcggc ctggccagac catcagacac cagaatcagc     1380

tgggcccctg ctgcgcctag tggcagaggt ggaggagagc ccggagacag ccgcccaccc     1440

cgggcctatc gtagtccact gcagtgcagg gattggccgg acgggctgct tcatcgccac     1500

gcgaattggc tgtcaacagc tgaaagcccg aggagaagtg gacattctgg gtattgtgtg     1560

ccaactgcgg ctagacagag gggggatgat ccagacggca gagcagtacc agttcctgca     1620

ccacactttg gccctgtatg caggccagct gcctgaggaa cccagcccct gacccctgcc     1680

accctccggt ggcccaggtg cctacctccc tcaagcctgg gaaggtgggt ctggggaaag     1740

tgggccgagt gatctggggg taccccttgg gttggtgtgg ggaaggagtg cctccttagt     1800

ggtgcttgca gtcacaggaa gcagcagcag taaggacaag gggccggatt ccaggtcttc     1860

aacactggcc actcctctgc ttcctctgtt ggccccagat ggacagtaag gggaacctcc     1920

aatgtctctc tgaacttaaa gacaggagct ggcatttatg acagacaaag aaagaagccc     1980

aggtgtcctg gtgttctctg agacactctt tgtgagcttc agtttcctgt tctataacat     2040

gaacataagt gcttagctgc catgagggaa aagtaatgag agaagtttct agaagccact     2100

ccagccactc cttcctgggg ctgacaaaag ggtgattcca agatcatcct tcacccgagg     2160

tcctgcccaa gcacaggcca gatgcaagaa tggggaaaag tctggtcctg atctccaagt     2220

ctcaacatcc tatcagtgac tctgctccct gaccacacat cggaagggct ggatgacccc     2280

aatcaaaaga aagaacaagg actctggtta cccttgcctc cacccatgtg tcataagagt     2340

aggctacaga ggtgaccagg cctggcagtt gaaatctctg gaagagggaa catgtgggga     2400

ctactcagag gcaaagagga gctgctcctg cctccatggt tgctggccac tcccaccaac     2460

tactcttagg gaggctaagc agtctctgtt ttgcttccat ggctcaaata ataccctggg     2520

tatgcaggac ccactatacc ttgcatttgc tgagtacacc tagagagctt ggctgtttcc     2580

aaaaacaatc agggtcataa ccatccatgc agacatggag gctcggctga accaggactc     2640

ctcactgtct acctgagaga atgagcaccc ctcatccatc tcagcatcaa cacaatttcc     2700

aggggacctc aggtctacct caggactgaa cgccacacct caggattcct cctccttgaa     2760

tctgagactg gctgcccatt ctgagatggg gatgaaggta agatgccgca tcaccaggca     2820

cgccgcccct gacagctgcc ttgataccag ctctctgtgg aaacccccga ggagttggat     2880

ctggagaaca gctgggcctc ctcactcagg acttctctcc tgaagaacac gcagtgctaa     2940

aactgaggat gatttcccta atgcttctgc ttggccttat ggaggagctg ctccttcctt     3000

acagccttgg ggatggactt gcccacacct ccacctcccc tgagccctgt gagaggcacg     3060

actgtctatg ccaatgaggc tcggtggggg gctctcaagt gcctgatcct gccctgggct     3120

cagagccagc ccagagggaa gcaactgcac agccccacag gccctccctg gcactgtccc     3180

cccaacccca tctcagagct cagagggtac aagctccaga acagtaacca agtgggaaaa     3240

taaagacttc ttggatgact gac                                             3263


<210>  72
<211>  548
<212>  DNA
<213>  Homo sapiens

<400>  72
cggcgctgcg gcagtccaga tcaaaaatgg cggtagttgg tgtgtcctcg gtttctcggc       60

tgctgggtcg gtcccgccca cagctggggc ggcctatgtc gagtggcgcc catggcgaag      120

agggctcagc tcgcatgtgg aagactctca ccttcttcgt cgcgctcccc ggggtggcag      180

tcagcatgct gaatgtgtac ctgaagtcgc accacggaga gcacgagaga cccgagttca      240

tcgcctaccc ccatctccgc atcaggacca agccgtttcc ctggggagat ggtaaccata      300

ctctattcca taaccctcat gtgaatccac ttccaactgg ctacgaagat gaataaagag      360

aatctggacc actacccggg caccagggac cacagcactg gtttggaccg ttactctgca      420

catggaccag aaaaagtata tgggacctta agctaacctt ctttacttgt atcaaatgat      480

gactggtata ctggtctccc atccctttgc ttgtggcagg agatggctta aataaataac      540

ttaaactt                                                               548


<210>  73
<211>  1899
<212>  DNA
<213>  Homo sapiens

<400>  73
agcgcgcgac tttttgaaag ccaggagggt tcgaattgca acggcagctg ccgggcgtat       60

gtgttggtgc tagaggcagc tgcagggtct cgctgggggc cgctcgggac caattttgaa      120

gaggtacttg gccacgactt attttcacct ccgacctttc cttccaggcg gtgagactct      180

ggactgagag tggctttcac aatggaaggg atcagtaatt tcaagacacc aagcaaatta      240

tcagaaaaaa agaaatctgt attatgttca actccaacta taaatatccc ggcctctccg      300

tttatgcaga agcttggctt tggtactggg gtaaatgtgt acctaatgaa aagatctcca      360

agaggtttgt ctcattctcc ttgggctgta aaaaagatta atcctatatg taatgatcat      420

tatcgaagtg tgtatcaaaa gagactaatg gatgaagcta agattttgaa aagccttcat      480

catccaaaca ttgttggtta tcgtgctttt actgaagcca atgatggcag tctgtgtctt      540

gctatggaat atggaggtga aaagtctcta aatgacttaa tagaagaacg atataaagcc      600

agccaagatc cttttccagc agccataatt ttaaaagttg ctttgaatat ggcaagaggg      660

ttaaagtatc tgcaccaaga aaagaaactg cttcatggag acataaagtc ttcaaatgtt      720

gtaattaaag gcgattttga aacaattaaa atctgtgatg taggagtctc tctaccactg      780

gatgaaaata tgactgtgac tgaccctgag gcttgttaca ttggcacaga gccatggaaa      840

cccaaagaag ctgtggagga gaatggtgtt attactgaca aggcagacat atttgccttt      900

ggccttactt tgtgggaaat gatgacttta tcgattccac acattaatct ttcaaatgat      960

gatgatgatg aagataaaac ttttgatgaa agtgattttg atgatgaagc atactatgca     1020

gcgttgggaa ctaggccacc tattaatatg gaagaactgg atgaatcata ccagaaagta     1080

attgaactct tctctgtatg cactaatgaa gaccctaaag atcgtccttc tgctgcacac     1140

attgttgaag ctctggaaac agatgtctag tgatcatctc agctgaagtg tggcttgcgt     1200

aaataactgt ttattccaaa atatttacat agttactatc agtagttatt agactctaaa     1260

attggcatat ttgaggacca tagtttcttg ttaacatatg gataactatt tctaatatga     1320

aatatgctta tattggctat aagcacttgg aattgtactg ggttttctgt aaagttttag     1380

aaactagcta cataagtact ttgatactgc tcatgctgac ttaaaacact agcagtaaaa     1440

cgctgtaaac tgtaacatta aattgaatga ccattacttt tattaatgat ctttcttaaa     1500

tattctatat tttaatggat ctactgacat tagcactttg tacagtacaa aataaagtct     1560

acatttgttt aaaacactga accttttgct gatgtgttta tcaaatgata actggaagct     1620

gaggagaata tgcctcaaaa agagtagctc cttggatact tcagactctg gttacagatt     1680

gtcttgatct cttggatctc ctcagatctt tggtttttgc tttaatttat taaatgtatt     1740

ttccatactg agtttaaaat ttattaattt gtaccttaag catttcccag ctgtgtaaaa     1800

acaataaaac tcaaatagga tgataaagaa taaaggacac tttgggtacc agaaaaaaaa     1860

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaa                            1899


<210>  74
<211>  986
<212>  DNA
<213>  Homo sapiens

<400>  74
gcaggcgcag acgcgcgggc gggaagatgg cggctgggtt caaaaccgtg gaacctctgg       60

agtattacag gagatttctg aaagagaact gccgtcctga tggaagagaa cttggtgaat      120

tcagaaccac aactgtcaac atcggttcaa ttagtaccgc agatggttct gctttagtga      180

agttgggaaa tactacagta atctgtggag ttaaagcaga atttgcagca ccatcaacag      240

atgcccctga taaaggatac gttgttccta atgtggatct accacccctg tgttcatcga      300

gattccggtc tggacctcct ggagaagagg cccaagtggc tagccaattc attgcagatg      360

tcattgaaaa ttcacagata attcagaaag aggacttatg catttctcca ggaaagcttg      420

tctgggttct atactgtgat ctcatttgcc tcgactacga tggaaacatt ttggatgcct      480

gcacatttgc tttgctagcg gctttaaaaa atgtacagtt gcctgaagtt actataaatg      540

aagaaactgc tttagcagaa gttaatttaa agaagaaaag ttatttgaat attagaactc      600

atccagttgc aacttccttt gctgtgtttg atgacacttt gcttatagtt gaccctactg      660

gagaggagga acatctggca acaggaacct taacaatagt aatggatgag gaaggcaaac      720

tctgttgtct tcacaaacca ggtggaagtg ggctaactgg agctaaactt caggactgta      780

tgagccgagc agttacaaga cacaaagaag ttaaaaaact gatggatgaa gtaattaaga      840

gtatgaaacc caaataaaca gccaccacat tttcaaaaca gatttgtaaa aattgtattt      900

gttaacactg tgcacaaacg ttttatacta aataaatatc aaactacatt cttccgaaaa      960

aaaaaaaaaa aaaaaaaaaa aaaaaa                                           986


<210>  75
<211>  1362
<212>  DNA
<213>  Homo sapiens

<400>  75
gaggcttcca aggcaggata cttgtgtctc agatgcggtc gcttctttca tacagcaatt       60

gccgccttgc tgaggatcaa ggaacctcag tgtcagatca cgccctcccc ccaaacttag      120

aaattcagat ggggcgcaga aatttctctt gttctgcgtg atctgcatag atggtccaag      180

aggtggtttt tccaggagcc cagcacccct cctccctccg actcagaccc aggagtctgg      240

ccctccattg aaaggacccc aggttacatc atccattcag gctgcccttg ccacgatgga      300

attctgtagc tcctgccaaa tgggtcaaat atcatggttc aggcgcaggg agggtgattg      360

ggcgggcctg tctgggtata aattctggag cttctgcatc tatcccaaaa aacaagggtg      420

ttctgtcagc tgaggatcca gccgaaagag gagccaggca ctcaggccac ctgagtctac      480

tcacctggac aactggaatc tggcaccaat tctaaaccac tcagcttctc cgagctcaca      540

ccccggagat cacctgagga cccgagccat tgatggactc ggacgagacc gggttcgagc      600

actcagggct gtgggtttct gtgctggctg gtcttctgct gggagcctgc caggcacacc      660

ccatccctga ctccagtcct ctcctgcaat tcgggggcca agtccggcag cggtacctct      720

acacagatga tgcccagcag acagaagccc acctggagat cagggaggat gggacggtgg      780

ggggcgctgc tgaccagagc cccgaaagtc tcctgcagct gaaagccttg aagccgggag      840

ttattcaaat cttgggagtc aagacatcca ggttcctgtg ccagcggcca gatggggccc      900

tgtatggatc gctccacttt gaccctgagg cctgcagctt ccgggagctg cttcttgagg      960

acggatacaa tgtttaccag tccgaagccc acggcctccc gctgcacctg ccagggaaca     1020

agtccccaca ccgggaccct gcaccccgag gaccagctcg cttcctgcca ctaccaggcc     1080

tgccccccgc acccccggag ccacccggaa tcctggcccc ccagcccccc gatgtgggct     1140

cctcggaccc tctgagcatg gtgggacctt cccagggccg aagccccagc tacgcttcct     1200

gaagccagag gctgtttact atgacatctc ctctttattt attaggttat ttatcttatt     1260

tattttttta tttttcttac ttgagataat aaagagttct agaggaggat aaaaaaaaaa     1320

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aa                        1362


<210>  76
<211>  1201
<212>  DNA
<213>  Homo sapiens

<400>  76
cgcggttcgg tcggctgcag cgctactttt ggtccggggt cggcagggag gccgcggcta       60

ccgcatcaca gctgacgtga ggactacgtg gggccgctgc cggctccggg ttgctgggcg      120

gcggcgccgc tgctgagcgg cggtcgggct cgccgtctcc acctcctcgc gtccgtaatc      180

agtgacgagg tccgctacgt aaatcccttt gcggcggaca aatgaccatg gaaacagttg      240

aatcccagca tgatggaagt ataacagctt ctttgacaga gagcaagtct gctcatgtgc      300

agactcagac tggccaaaat tcaatccctg ctttagctca ggtagcagca attgcagaga      360

cagatgaatc tgcagaatca gaaggtgtaa ttgattctca taaacgtaga gaaatccttt      420

cacgaagacc ctcttatagg aaaatactga atgaactgtc ctctgatgtg cctggtgttc      480

ccaagattga agaagagaga tcagaggaag aaggaacacc acctagtatt gctaccatgg      540

cagtaccaac tagcatatat cagactagca cggggcaata cagtatgtat gctgcaattc      600

gatatgatac agtgctagct ttaagtcttc tctagttata ttgaagcaac tcaggttttg      660

gcattaaatt gttccatttt aaaatgcatc attaatacct aaactgtatc atagaatgaa      720

agtatatgtt aaaaagtgag atctttgtat tgacagctgt catataattt tgaaaagtaa      780

aaattttgac tgccgaatat agaagaaaat tttggggtaa aaaggagaat ttttcctatt      840

tacatgttta tattaatctc tagtaaaaca ttgtttttgt tgtctttatg atgcatgcga      900

acataaatgt ctgtatttca ttcttgttgg cttttgttac ccacaattac atactattct      960

tactaatctg agagttttct aaagtatgtt ttcaatgttt cactactctc tactctgtta     1020

atttgtgcta cagtttttcc taaaagagaa tggaaaaatg atttaatttt ttaaactgta     1080

gcaattggat agataatttt atttgaaatt ttacacactg aaagctctaa ataaacagat     1140

acattcacaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa     1200

a                                                                     1201


<210>  77
<211>  1737
<212>  DNA
<213>  Homo sapiens

<400>  77
atgaggggtc cccctgcttg tcttcacccc tgccagagcc tctgggcccc ctcctccctc       60

ctgtagctct ccctaggctg cccactctcc atcctcccca ggggtagagg ctgggggctc      120

caccccagcc catgtacgtc cccacgaact ggcctggcca gcaccccaca ctggagccat      180

ctcttcctca tatttcagca gtgcagccgg ggggcaggga agggcaggca gggtctgttg      240

gggtctcttt ttatccttat tcctcccccg acctaattgt ctttgttctg tgattattgg      300

gggacacccg gctccctcca gacaatgcca gcataaatcc atccatccaa aggcagagaa      360

ccaaaggggc catggaaggt tctctgtgct cctcctaccc ttccagtgcc ctaggcctgg      420

cgactgcccc tgccttttag acccgccctc cccttttata cctgctcttg ttctactgag      480

aaaagcctct ccagcaataa tgttttctag tcacttcctc cgtctccggg acggcgtgcc      540

tggacactgt accgactttg atagatttct acactgaggt ttgaattcat atcgcctgag      600

ttgcttttac ttctctatac aaaatgattt tgaagagatt ttaaagacgt tcccttttgt      660

attctcttcc tcatccaccg ccactgggcc tgtcactgat ggtggctctg gtgtgaagtt      720

tgctttgtac tgagggttgg ggtggggaag caatttgtat tttattgttt cttagcacaa      780

gcaggtgaac tgggagcagc tctgtgactc cccctctttc acttcatagc tcaccaggac      840

tgttttataa actgctgtat ttggaaaccc cttctttact tcccaggcca gcaagctctt      900

cactgaaact ggttgaaggg tgttgcaccc ttttgggcct agaattctga actttatctg      960

ttctgtttct gtgggaggag aaggggaagt atgttttggg gggctgcttc ctgtctgagt     1020

aagccctcag gagcctctgc tcccctgtga acccactgaa ccttctgagc ccccactgct     1080

tctatggggc tctctcttct gccttctcag gaaagctggt gtctgatttt ggccatcagg     1140

actctgacgt ctctttggtc ttgttgattt cctctgggca tatcccttcc ccagatctgc     1200

tcctcccctt tcacaggtgg gatcggcact cagggggtct ggaaagaagg tcataaggga     1260

gcatgatagg atttggggca gagggacagg ctcctctggg gaaacccccc agagctcttt     1320

accaaggatg aaagaggagc caggccttgg gctcctgatg aggagaaagg ggccccaccg     1380

gggtctaatg gtgacagtcc aaaccactcc actggcctcc tggcagaagc cgagtgtgct     1440

ggggtctccg aagagggtcc ctcctttttg ggggaaggtc agcccagccc ctccaaaggt     1500

ctgatgtctc cactttcacc cgcaggcctt accgctctgt ttatagtgac ccaccctaga     1560

tcttccccaa gagggactgg ggtttctggg gtccattctc tgagtcagtg gttatttgaa     1620

aatttgattt tgattttatt ttttctctgt aaacttccaa gctggctttt cccatttcaa     1680

ttcctgtgat ttatgccaat aaagtttgcc catgattttc aaaaaaaaaa aaaaaaa        1737


<210>  78
<211>  2748
<212>  DNA
<213>  Homo sapiens

<400>  78
ctgccatgtg accggcgggt gttctacaag ggctgaccag tgggcgggac agaacgcaaa       60

gggcgatatt aaaagccgga ctcttccggt gaagcggagg tgtggtgggg cttgctggga      120

tcatggcggg gaatcactgc gagctcctgc cgctggcccg tggcaggctc ggggcggggt      180

tggggtggct tcttgtgcct cccttaaagc gcggggctca gcgtcctggc ccagcgcccc      240

agcagcaggt ccaagtgggt ccggctctac agcggcggca cctacttcct caccactggg      300

cagacgccgc tgtgtcagga cccgaaatcc ttcctgtacc tcttgagcca ggccgacccc      360

gacccggact cggacaagac ggagttttgt tcttgttgcc caagctggag tacaatggca      420

caatcttggc tcaccacaac ctctgccacc tgggttcaag cgagtctcct ccttcagtct      480

cctgagtagc tgggattaca ggcatgcacc accacacaca gctaagtttt atatttttag      540

tagagatggt ttcaccatgt tggccaggcc agtctcaaac tcctgacctc gtgatccgcc      600

caccttggcc tcccaaagtg ctgggattac aggtgtgagc caccacaccc agccaattag      660

ggctgtctta caaaaaaaaa aaccaccacg aacctttgcg agaatcgagc gcagcctgtg      720

ctggttgtgt aagccgtggg acacacggga aagccaggaa gaagaggaag agcaccccca      780

caccccaccc gcgtgaagaa gagcaacccc actccccgcc cgtgggaaga agagcaccct      840

cacgccgggc ccgcaggaag aagagcaccc ccacgcccgg cccgcagcat cccgctggct      900

tcctggccac ctctcctcac ccatcttaga ggcatggccg ggctggggca tctttccctc      960

cttgggcagg atgaaacagg cgcctattta atcgacagag accccaccta ctttgggcct     1020

gtgctgaact acctgagaca cggcaagctg gtgattaaca aagacctcgc ggaggaagat     1080

gataccacga gtcaacccaa aagttgctgg ggagaagttg ctctttaatg aattgcatct     1140

catgaatgta tcaggctgtg acctttctgc actctctaat gagttcatga atttaggcca     1200

attatggcca caaatgctgc tgctgtcaca gagagatgcc ggataaagaa cacccaccac     1260

cagtctctga acagggaggg gagaatcaac tctgaatgtg atgtagtggc caggagagag     1320

gaccatgttc aacaatgcca cacagatgca aatgacttgt ttcttcaaca aactgcaagg     1380

gaaaaaataa aaatggggga agctacagat taaaatacat gtgtttggat aggagagtat     1440

ttaatggcaa aagaaaaaga aaaaatttaa aaataaaatt gtgcaaaact tatttgaatc     1500

ctgttcaagt gagcaacaaa acattatgat gtacatgaga caactggaaa tataactctg     1560

actggacact ttgagatatt aagcaattac cgttcatttt tacatatcaa acagtatggt     1620

attgtggtta cgcttttaaa aagatttgta ttttagcgac acatactgga atttttacag     1680

ggaaaaccca ctgaggatgc tgggcatcag gtcactagca ccgagtgaat tttttacaat     1740

aagcagtaat tctccccagc cccatgcatc atagccaatc ctaaatgaat gccaatctgg     1800

aaaagaccaa aataaaccac gtgaagatgg gaagagctgc tcttggtgat gggagaatgg     1860

ggactctctc ttttattgtg caaattccac tttccatcat gcaggaaaat ccgtcttgaa     1920

ggcagctcct ctctgtgccg ggggtgggtg atccagccta agctagaatg gcggcaagct     1980

caaggcagct gtggccctca ggagagcgtc tggagtccac agcacagtgg gaagcgcaac     2040

ggcagctagt ctgagggtct ggacgatggc catgcacaga tgaggacaga ggagccactg     2100

tagtgactga agcccacggc atccaccctc tccagccagc cccgcccaca cctgaagccc     2160

acagcgtcca ccctgtccac ccagccctgc ccacacctgt ggccttcctc tccttcctgt     2220

ttggtgagtg ctgcctccac acctggctgc atgccagaaa ggcctgcaca ggtcagaaca     2280

caggtttcca aaccctactc caagtctgaa cctccaagga caccccgagc tccccaaggt     2340

tcttgcatag agggcacagg ccagagacag cccaggtggg aagcttactc tgagtcagct     2400

gccctcacca agatacatcc acaggctcct gtacaaggag aggaggcaga agtccctctc     2460

tgccaggagg tcctcctcaa tctcccaagc ccacaccact gccctgctcc atctcccacc     2520

acctccccct gcagatacgg gggccaccct acccacccca caggaacgat gggaaaacct     2580

gcctccctct aggaggaggg cgtggcacgg ctgctgcgcg ggtaaggaac ctcgctatgc     2640

cttgctccca tcaacacttt tattctagat ttgaaggtgt tttggggaag ccatctctgc     2700

acaaaagaag tcaacgcagg aataaattcc aagatactga actacctc                  2748


<210>  79
<211>  2305
<212>  DNA
<213>  Homo sapiens

<400>  79
ggcaacaggc agatttgcct gctgagggtg gagacccacg agccgaggcc tcctgcagtg       60

ttctgcacag caaaccgcac gctatggctg acagccggga tcccgccagc gaccagatgc      120

agcactggaa ggagcagcgg gccgcgcaga aagctgatgt cctgaccact ggagctggta      180

acccagtagg agacaaactt aatgttatta cagtagggcc ccgtgggccc cttcttgttc      240

aggatgtggt tttcactgat gaaatggctc attttgaccg agagagaatt cctgagagag      300

ttgtgcatgc taaaggagca ggggcctttg gctactttga ggtcacacat gacattacca      360

aatactccaa ggcaaaggta tttgagcata ttggaaagaa gactcccatc gcagttcggt      420

tctccactgt tgctggagaa tcgggttcag ctgacacagt tcgggaccct cgtgggtttg      480

cagtgaaatt ttacacagaa gatggtaact gggatctcgt tggaaataac acccccattt      540

tcttcatcag ggatcccata ttgtttccat cttttatcca cagccaaaag agaaatcctc      600

agacacatct gaaggatccg gacatggtct gggacttctg gagcctacgt cctgagtctc      660

tgcatcaggt ttctttcttg ttcagtgatc gggggattcc agatggacat cgccacatga      720

atggatatgg atcacatact ttcaagctgg ttaatgcaaa tggggaggca gtttattgca      780

aattccatta taagactgac cagggcatca aaaacctttc tgttgaagat gcggcgagac      840

tttcccagga agatcctgac tatggcatcc gggatctttt taacgccatt gccacaggaa      900

agtacccctc ctggactttt tacatccagg tcatgacatt taatcaggca gaaacttttc      960

catttaatcc attcgatctc accaaggttt ggcctcacaa ggactaccct ctcatcccag     1020

ttggtaaact ggtcttaaac cggaatccag ttaattactt tgctgaggtt gaacagatag     1080

ccttcgaccc aagcaacatg ccacctggca ttgaggccag tcctgacaaa atgcttcagg     1140

gccgcctttt tgcctatcct gacactcacc gccatcgcct gggacccaat tatcttcata     1200

tacctgtgaa ctgtccctac cgtgctcgag tggccaacta ccagcgtgac ggcccgatgt     1260

gcatgcagga caatcagggt ggtgctccaa attactaccc caacagcttt ggtgctccgg     1320

aacaacagcc ttctgccctg gagcacagca tccaatattc tggagaagtg cggagattca     1380

acactgccaa tgatgataac gttactcagg tgcgggcatt ctatgtgaac gtgctgaatg     1440

aggaacagag gaaacgtctg tgtgagaaca ttgccggcca cctgaaggat gcacaaattt     1500

tcatccagaa gaaagcggtc aagaacttca ctgaggtcca ccctgactac gggagccaca     1560

tccaggctct tctggacaag tacaatgctg agaagcctaa gaatgcgatt cacacctttg     1620

tgcagtccgg atctcacttg gcggcaaggg agaaggcaaa tctgtgaggc cggggccctg     1680

cacctgtgca gcgaagctta gcgttcatcc gtgtaacccg ctcatcactg gatgaagatt     1740

ctcctgtgct agatgtgcaa atgcaagcta gtggcttcaa aatagagaat cccactttct     1800

atagcagatt gtgtaacaat tttaatgcta tttccccagg ggaaaatgaa ggttaggatt     1860

taacagtcat ttaaaaaaaa aatttgtttt gacggatgat tggattattc atttaaaatg     1920

attagaaggc aagtttctag ctagaaatat gattttattt gacaaaattt gttgaaatta     1980

tgtatgttta catatcacct catggcctat tatattaaaa tatggctata aatatataaa     2040

aagaaaagat aaagatgatc tactcagaaa tttttatttt tctaaggttc tcataggaaa     2100

agtacattta atacagcagt gtcatcagaa gataacttga gcaccgtcat ggcttaatgt     2160

ttattcctga taataattga tcaaattcat ttttttcact ggagttacat taatgttaat     2220

tcagcactga tttcacaaca gatcaatttg taattgctta catttttaca ataaataatc     2280

tgtacgtaag aacaaaaaaa aaaaa                                           2305


<210>  80
<211>  4395
<212>  DNA
<213>  Homo sapiens

<400>  80
gtagtcgtgg cgctctcgag gccctgccat gagcaagctc ttaactcttc aggtctgcac       60

gtcctacgcc caccgtccag tgctactctc agctcggagt tcagcttcgg gctgccaaga      120

gccagcaacc tggtgtcaga ggctcggtcc cacaacgctc tgcgggccgc ggcgcctgct      180

gggaggtgta gtccccgatc tgcgtactgc gttcgccgag ggggagggcg gagctgccgg      240

cggcccgggc gggctggcag ctagagtggg tgcgatagcc gcctccgcct ctgccgcctc      300

cgccgtcgcc tcctccgccc gggccgttcg ctgctgcgcg gggagagcga ggcggggccg      360

ccggggccgc catggagccc gactcggtga ttgaggacaa gaccatcgag ctcatgaaca      420

cttcagttat ggaagatcaa aatgaagatg agtccccaaa gaaaaatact ctttggcaga      480

taagtaatgg aacatcatct gtgatcgtct ccagaaagag gccatcagaa ggaaactatc      540

aaaaagaaaa agacttgtgt attaaatatt ttgaccagtg gtctgaatca gatcaagtgg      600

aatttgtgga acatcttatt tcacgaatgt gtcattatca gcatggacat attaactctt      660

acctgaagcc catgttgcag cgggacttta ttaccgcttt accagagcaa ggcttagatc      720

acatagcaga aaacattctt tcgtacctgg atgccaggtc tctgtgtgca gcagagctgg      780

tatgtaaaga atggcagcga gtgatctcag aaggaatgct ttggaagaag ctgattgaac      840

gaatggtacg cactgatccc ctatggaaag gactttcaga aagaagaggg tgggatcagt      900

acctgtttaa aaacagaccc acagatggcc ctccaaattc attttatagg tcattatacc      960

caaagattat ccaggatata gagactatag aatctaactg gcggtgtgga cgacacaact     1020

tgcagaggat tcagtgccgc tctgaaaata gtaaaggtgt ctactgttta cagtacgatg     1080

atgaaaaaat tatcagtggc ctacgagata attctattaa gatatgggat aaaaccagcc     1140

tggaatgttt gaaagtgtta acaggacaca caggctctgt cctctgtctg cagtatgatg     1200

agcgtgtcat tgtaactggc tcttcagatt ctacggtgag agtgtgggat gtgaacacgg     1260

gtgaagttct taacacattg atccaccaca atgaggctgt attgcactta cgcttcagca     1320

atggactgat ggtgacctgt tccaaggacc gctccattgc tgtgtgggac atggcttctg     1380

cgaccgacat cactttacgc cgtgtcctgg ttggccaccg ggctgccgtc aatgtagtag     1440

actttgacga caagtacatc gtgtctgcct ctggtgacag gaccatcaaa gtctggagca     1500

cgagcacctg tgaatttgtt cgtactctca atgggcacaa gcggggcatt gcctgtctcc     1560

agtacaggga tcgcctggtt gttagtggat catcagataa taccattagg ctctgggata     1620

ttgaatgtgg tgcctgttta agagtcctag agggacatga agaattggtc cgatgcatcc     1680

ggtttgataa caagaggatt gtcagtgggg cctatgatgg gaaaattaaa gtttgggact     1740

tgcaagctgc tcttgaccct cgagccccag caagcacatt gtgtttgcgc acattggtgg     1800

aacattctgg acgtgtgttt cggctccagt ttgatgagtt tcagatcatc agcagctccc     1860

atgatgacac tattttgatt tgggatttct taaatgtgcc tcccagtgcc cagaatgaga     1920

cccgttctcc ctccagaaca tacacttaca tctctagata acagtctgca ctttcacccg     1980

tttcagggtt ttctagtctt gaactactgg ctacgtggct accaaatgcc taagggagtt     2040

cgttcacagc tgagttatga agctggaatt ggttctagac gctgggtaga tgcaaagcag     2100

cctaactctt caagtaccga catttctcac ctctgattcc ggctctcctt tgagaaggag     2160

accttagctt ccccggcttc aagtagaaca gaagcccgtt tccttccctc atcagtgaaa     2220

aaatctaatg tttcaaatgt aaattgttca tagaaaagga acatagaatc tgttttacag     2280

aagtaaatcg accgtcaaga gaagacttgg cctctaattt atattgcttt gcactttggt     2340

ttgatattaa gaaacagcat tcttcttcag tgaaattttg ggtgccaaac acctacccag     2400

aatgtccagg gctttcattt tcaaaagtta gcattctcct tttgaccgtc caagtcatta     2460

tgaattctga cttgttgtat taggaacatg ttggacagtg gaaaattttc tctggattgt     2520

tttagtaata tttttgggat tatacttcct ttctgtacca atttctttta atttaaagaa     2580

ctataagtca gttatattat ctaccaacag gtaatatagc tctttctttt attaactgtt     2640

ctctgtcccc caaccatctc ctgatatttg gtagagtaac acctttatac gtgtgcttgc     2700

ctcctaattt aaaatactgt attcgcatgt agatataatg tacataacag tttaacctca     2760

aagttgctgg agtcagggcc ccctgtgctt gagacactaa tacagagtgt gttcgcactt     2820

agccatgggc tgggctcaag aacctgatac ctgggttgat gtggattacc tagaaccctt     2880

cctgcagtat tcatacagtg tttttatttt gttgttgtca ttgcgtgtgt gtggtttgtg     2940

tgtgttttta atgagaatct tgttttaaaa tgtaatttct aaggtttaac accaaaatgt     3000

tttatttgtt gtggagtata tattatacaa tagagaggta ccttaaacat tttttgttct     3060

tattcttttt ctcataagta ctcctgagta caagtggtca cctcccatag tattcatttg     3120

gcttcgctgt caaaaatcat tattctgtgc agtcgtggcc ctgggaaggg gaaataagaa     3180

ggccctgttg acgggctgtc ttggctctgg aattcatgca tcctggcctt gccaaggttc     3240

tggcagggcc tgctggtgtg ttggagcctg cagggcaggt caggctggtt cagaggccca     3300

tgctgagggg tgggtgctct gaagtggagt gaagcctcaa gcccatgaat gccaccccag     3360

tcatctctgg tgtcagctgc tgctgtggcc ccagcaggtt ctcaaagctc ccaagtcctc     3420

cctacgacac agcccaaatg tgtaaatggc actgttgccc tgacagtgca tggaaaggac     3480

gttggcatcc aattggcact ccttctccct tattcaatat taggtttgat ttgcccttcg     3540

ccattgtttc caaagatcaa ggaatgtcaa taacatttta aaggaccaat aaacagcctc     3600

ctataaagta aacctcttcc cgtggaagca cactctacta ctaaagggaa ggcccctggg     3660

ctctgatttg tcctttgcat tgagaacggt gtggggatca gtgtgtgtgt atgtgatttg     3720

tttattgagt tggctttgct tttttagttt ttcttttaaa aataaaatcc ttccttccca     3780

tgttactaaa ttaatttatg tttttgagag gttgagtctc aaagtgtaaa caataaacct     3840

ccattcataa ggtggatgtt gtaagcttga tggtggttgt gaaagtgatt tagctttgac     3900

cacttttcat cctacagctt caatatcaaa ctggttagga aagcccaggg ggaagggagg     3960

gggcagggga ggaggcaatt ctgaatgaat gaatggattt tttgttgttt ttgcatgttt     4020

aatatagaag ttcccctcgt tccttgggag atgatggcct ttgaatatgc agacaacctt     4080

tgaattgtgc ctactaaatt atagcagggg actttggcac ccaaggagtt ctgactttct     4140

gggattataa tagtaattcc cagccatact ctggacttta ttttgctaac cataactgag     4200

caaatgtaaa ttactgctat attaatgttt taaagcactg ggatagtcta attctaactt     4260

gtaattaatt atgtttgcca attatctgtt tgaaataaat ttgtgtctga acagctattg     4320

aaactgttaa attgtacaga tattattcat gacagctttg tactgtggaa tgtgcttaat     4380

aaaaaaaaaa aaaaa                                                      4395


<210>  81
<211>  1161
<212>  DNA
<213>  Homo sapiens

<400>  81
attaacaaag atggtgctta tggggcaggt tccctaacag tcaggattcc ggttgcagtt       60

tttctccccc gccccaaaga tacgtggttg cagacggaga aatggaggcc agagacaaac      120

aagtactccg ctcacttcgc ctggagctgg gtgcagaggt attggtggag ggactggttc      180

ttcagtacct ctaccaggaa ggaatcttga cggaaaacca tattcaagaa atcaatgctc      240

aaaccacagg cctccggaaa acaatgctcc tgctggatat cctaccttcc aggggcccta      300

aagcatttga tacattccta gattccctac aggagtttcc ctgggtcagg gagaagctga      360

agaaggcaag ggaagaggcc atgaccgacc tgcctgcagg tgacagattg actgggatcc      420

cctcgcacat cctcaacagc tccccatcag accggcagat taaccagctg gcccagaggc      480

tgggccctga gtgggagccc atggtgctgt ctctgggact gtcccagacg gatatctacc      540

gctgtaaggc caaccacccc cacaacgtgc agtcgcaggt ggtggaggcc ttcatccgtt      600

ggcggcagcg cttcgggaag caggccacct tccagagcct gcacaacggg ctgcgggctg      660

tggaggtgga cccctcgctg ctcctgcaca tgttggagtg atggtgcctc cagcaaccgc      720

tggggagtgt gtccctgagt catgtgggct gaatcctgac tttcactcag agcaggtggt      780

tttttgtgta ggtttgtttt ttatttttga tgatcttcag atggaaggag aaaacagggt      840

ttccactaga cattacttga aaggccagat tactcagcag atctcccatg ttggctcaac      900

aattctttgt ttttaattgc ttgaagattg cattgttgta attgttcagt ttttaaatgt      960

gtaatggcat tttaatagac tagtaaatca cagtggttca aaatatatat ccatatatat     1020

atatatccca tatatatatc tcatgtcatc acattacagg caggtgtctc atatgtaaaa     1080

catttacctg aatgttgtct gaggactgaa ctgtggactt tactattcat aatgataaaa     1140

taataaaatg cgaattacta t                                               1161


<210>  82
<211>  2864
<212>  DNA
<213>  Homo sapiens

<400>  82
ttgctgctgc tcagcgcagc cagtcgcgga ggcggggagg ctgcgcggtc agaggcgcct       60

ggagcgagcg aatcctggcc caccgcctgc ccaaccgcgt gaccttgatt gagttaatga      120

acttcacgcc tcagcgtcca gcgaaacccc aaagagtcag gtagggaccc tgctcttccg      180

cagccgcagc cgcctgacgc acctatccct gtctcgacgg gcatccgaat cctccctgtc      240

gtctgaatcc tccgaatctt ctgatgcagg tctctgcatg gattccccca gccctatgga      300

cccccacatg gcggagcaga cgtttgaaca ggccatccag gcagccagcc ggatcattcg      360

aaacgagcag tttgccatca gacgcttcca gtctatgccg gtgaggctgc tgggccacag      420

ccccgtgctt cggaacatca ccaactccca ggcgcccgac ggccggagga agagcgaggc      480

gggcagtgga gctgccagca gctctgggga agacaaggag aatgatggat ttgtcttcaa      540

gatgccatgg aagcccacac atcccagctc cacccatgct ctggcagagt gggccagccg      600

cagggaagcc tttgcccaga gacccagctc ggcccccgac ctgatgtgtc tcagtcctga      660

ccggaagatg gaagtggagg agctcagccc cctggcccta ggtcgcttct ctctgacccc      720

tgcagagggg gatactgagg aagatgatgg atttgtggac atcctagaga gtgacttaaa      780

ggatgatgat gcagttcccc caggcatgga gagtctcatt agtgccccac tggtcaagac      840

cttggaaaag gaagaggaaa aggacctcgt catgtacagc aagtgccagc ggctcttccg      900

ctctccgtcc atgccctgca gcgtgatccg gcccatcctc aagaggctgg agcggcccca      960

ggacagggac acgcccgtgc agaataagcg gaggcggagc gtgacccctc ctgaggagca     1020

gcaggaggct gaggaaccta aagcccgcgt cctccgctca aaatcactgt gtcacgatga     1080

gatcgagaac ctcctggaca gtgaccaccg agagctgatt ggagattact ctaaggcctt     1140

cctcctacag acagtagacg gaaagcacca agacctcaag tacatctcac cagaaacgat     1200

ggtggcccta ttgacgggca agttcagcaa catcgtggat aagtttgtga ttgtagactg     1260

cagatacccc tatgaatatg aaggcgggca catcaagact gcggtgaact tgcccctgga     1320

acgcgacgcc gagagcttcc tactgaagag ccccatcgcg ccctgtagcc tggacaagag     1380

agtcatcctc attttccact gtgaattctc atctgagcgt gggccccgca tgtgccgttt     1440

catcagggaa cgagaccgtg ctgtcaacga ctaccccagc ctctactacc ctgagatgta     1500

tatcctgaaa ggcggctaca aggagttctt ccctcagcac ccgaacttct gtgaacccca     1560

ggactaccgg cccatgaacc acgaggcctt caaggatgag ctaaagacct tccgcctcaa     1620

gactcgcagc tgggctgggg agcggagccg gcgggagctc tgtagccggc tgcaggacca     1680

gtgaggggcc tgcgccagtc ctgctacctc ccttgccttt cgaggcctga agccagctgc     1740

cctatgggcc tgccgggctg agggcctgct ggaggcctca ggtgctgtcc atgggaaaga     1800

tggtgtgggt gtcctgcctg tctgccccag cccagattcc cctgtgtcat cccatcattt     1860

tccatatcct ggtgcccccc acccctggaa gagcccagtc tgttgagtta gttaagttgg     1920

gttaatacca gcttaaaggc agtattttgt gtcctccagg agcttcttgt ttccttgtta     1980

gggttaaccc ttcatcttcc tgtgtcctga aacgctcctt tgtgtgtgtg tcagctgagg     2040

ctgggggaga gccgtggtcc ctgaggatgg gtcagagcta aactccttcc tggcctgaga     2100

gtcagctctc tgccctgtgt acttcccggg ccagggctgc ccctaatctc tgtaggaacc     2160

gtggtatgtc tgccatgttg cccctttctc ttttcccctt tcctgtccca ccatacgagc     2220

acctccagcc tgaacagaag ctcttactct ttcctatttc agtgttacct gtgtgcttgg     2280

tctgtttgac tttacgccca tctcaggaca cttccgtaga ctgtttaggt tcccctgtca     2340

aatatcagtt acccactcgg tcccagtttt gttgccccag aaagggatgt tattatcctt     2400

gggggctccc agggcaaggg ttaaggcctg aatcatgagc ctgctggaag cccagcccct     2460

actgctgtga accctggggc ctgactgctc agaacttgct gctgtcttgt tgcggatgga     2520

tggaaggttg gatggatggg tggatggccg tggatggccg tggatgcgca gtgccttgca     2580

tacccaaacc aggtgggagc gttttgttga gcatgacagc ctgcagcagg aatatatgtg     2640

tgcctatttg tgtggacaaa aatatttaca cttagggttt ggagctattc aagaggaaat     2700

gtcacagaag cagctaaacc aaggactgag caccctctgg attctgaatc tcaagatggg     2760

ggcagggctg tgcttgaagg ccctgctgag tcatctgtta gggccttggt tcaataaagc     2820

actgagcaag ttgagaaaaa aaaaaaaaaa aaaaaaaaaa aaaa                      2864


<210>  83
<211>  12244
<212>  DNA
<213>  Homo sapiens

<400>  83
gctcggtggt ttaaagatgg cggcggcggt ggcggcggcg gcggcggcgg cgttgggggc       60

gcggagccgc gacaggagga gggaaaagca gaatctgtga gtcgcctgga ggcagcgcgg      120

cggctgccgt gaggaggccg ggtgcggagc cgccggtggc ccagccactc agggccaggg      180

cctgggctgg gagggagaga ccggagcagc gccaggagcc cgaggccgga gccgaggagg      240

aatgtgacca ggggtcggcg ggggcgcggg agtacgcgag agcagggatg gggcagcagg      300

tgggccgcgt cggggaagct ccggggctcc agcagcctca gccccgcggg atccggggca      360

gcagtgcagc caggccctcc ggccgcaggc gggacccggc ggggcgcacc acagagaccg      420

gcttcaatat cttcacccag catgatcact ttgccagctg tgtggaggat ggatttgagg      480

gagacaagac tggaggcagt agtccagaag ctttgcatcg tccctatggt tgtgatgttg      540

aaccccaggc actaaatgag gctatcaggt ggagctccaa ggagaacttg ctcggagcca      600

ctgagagtga ccctaatctc ttcgttgcac tttatgattt tgtagcaagt ggtgataaca      660

cactcagcat cactaaaggt gaaaagctac gagtccttgg ttacaaccag aatggtgagt      720

ggagtgaagt tcgctctaag aatgggcagg gctgggtgcc aagcaactac atcaccccag      780

tgaacagcct ggaaaaacac tcctggtacc atggacctgt gtcacgcagt gcagctgagt      840

atctgctcag cagtctaatc aatggcagct tcctggtgcg agaaagtgag agtagccctg      900

ggcagctgtc catctcgctc aggtacgagg gacgtgtgta tcactacagg atcaatacca      960

ctgcagatgg caaggtgtat gtgactgctg agagccgctt cagcaccttg gcagagcttg     1020

tacaccatca ctccacagtg gctgatgggc tggtgacaac attacactac ccagcaccca     1080

agtgtaataa gcctacagtc tatggtgtgt cccccatcca cgacaaatgg gaaatggagc     1140

gaacagatat taccatgaag cacaaacttg ggggcggtca gtatggagag gtttacgttg     1200

gcgtctggaa gaaatacagc cttacagttg ctgtgaaaac attgaaggaa gataccatgg     1260

aggtagaaga attcctgaaa gaagctgcag taatgaagga aatcaagcat cctaatctgg     1320

tacaactttt aggtgtgtgt actttggagc caccatttta cattgtgact gaatacatgc     1380

catacgggaa tttgctggat tacctccgag aatgcaaccg agaagaggtg actgcagttg     1440

tgctgctcta catggccact cagatttctt ctgcaatgga gtacttagag aagaagaatt     1500

tcatccatag agatcttgca gctcgtaact gcctagtggg agaaaaccat gtggtaaaag     1560

tggctgactt tggcttaagt agattgatga ctggagacac ttatactgct catgctggag     1620

ccaaatttcc tattaagtgg acagcaccag agagtcttgc ctacaatacc ttctcaatta     1680

aatctgacgt ctgggctttt ggggtattgt tgtgggaaat tgctacctat ggaatgtcac     1740

catatccagg tattgacctg tctcaggtct atgacctact agaaaaagga tatcgaatgg     1800

aacagcctga gggatgcccc cctaaggttt atgaacttat gagagcatgc tggaagtgga     1860

gccctgccga taggccctct tttgctgaaa cacaccaagc ttttgaaacc atgttccatg     1920

actccagcat ttctgaagag gtagctgagg agcttgggag agccgcctcc tcgtcatctg     1980

ttgttccata cctgccccgg ctacctatac ttccttccaa gactcggaca ctgaagaaac     2040

aggtggagaa caaggagaac attgaagggg cacaagatgc cacagaaaat tctgcttcca     2100

gtttagcacc agggttcatc agaggtgcac aggcctctag tggatcccca gcactgcctc     2160

gaaagcaaag agacaagtca cccagcagcc tcttggaaga tgccaaagag acatgcttca     2220

ccagggatag gaaggggggc ttcttcagct ccttcatgaa gaagagaaat gctcctacac     2280

cccccaaacg cagcagctcc ttccgagaaa tggagaatca gccccataag aaatacgaac     2340

tcacgggtaa cttctcatct gttgcttctc tacagcatgc tgatgggttc tctttcactc     2400

ctgcccagca agaggcgaat ctggtgccac ccaagtgcta tggggggagc tttgcacaga     2460

ggaacctctg taatgacgac ggtggtgggg gtgggggcag tggcactgct gggggtgggt     2520

ggtctggcat cacaggcttc tttacaccac gcttaatcaa aaagacactg ggcttacgag     2580

caggtaaacc cacagccagt gatgacactt ccaagccttt tccaaggtca aactctacat     2640

cttccatgtc ctcagggctt ccagagcagg ataggatggc aatgaccctt cccaggaact     2700

gccagaggtc caaactccag ctggaaagga cagtgtccac ctcttctcag ccagaagaga     2760

atgtggacag ggccaatgac atgcttccaa aaaaatcaga ggaaagtgct gctccaagca     2820

gggagagacc aaaagccaag ttattgccca gaggagccac agctcttcct ctcagaacac     2880

cctctgggga tctagccatt acagagaagg accctccagg ggtgggagtg gctggagtgg     2940

cagctgcccc caagggtaaa gagaagaatg gtggggcacg acttgggatg gctggagttc     3000

cagaggatgg agagcagccg ggctggcctt ctccagccaa ggctgccccc gtcctcccaa     3060

ccactcacaa ccacaaagtg ccagtcctta tctcacccac tctgaaacac actccagctg     3120

acgtgcagct cattggcaca gactctcagg ggaataaatt caagctctta tctgagcatc     3180

aggtcacatc ctctggagac aaggaccgac cccgacgggt aaaaccaaag tgtgccccac     3240

ccccaccacc agtgatgaga ctactgcagc atccgtccat ctgctcagac cctacagaag     3300

agccaactgc cctaactgca ggacagtcca catcagaaac acaggaagga ggaaagaagg     3360

cagctctggg cgcagtgccc atcagtggga aagctgggag gccagtgatg cctccacctc     3420

aagtgcctct gcccacatct tccatctcgc cagccaaaat ggccaatggc acagcaggta     3480

ctaaagtggc tctgagaaaa accaaacagg ccgctgagaa aatctcagca gacaaaatca     3540

gcaaagaggc cctgctggaa tgtgctgacc tactgtccag tgcactcacg gaacctgtgc     3600

ccaacagcca gctggtagac actggacacc agctgcttga ctactgctca ggctatgtgg     3660

actgcatccc tcaaactcgc aacaaatttg ccttccgaga ggctgtgagc aaactggaac     3720

tcagcctgca ggagctacag gtttcttcag cagctgctgg tgtgcccggg acaaaccctg     3780

tccttaataa cttattgtca tgtgtacagg aaatcagtga tgtggtgcag aggtagccac     3840

tgttagcctg gtgggaaaat gcacacattt ctgaggggag agggaaaagg acttgttttc     3900

ctgtgttctt gttttcagaa aatgaaagac tcatacttga gtgtgtttat gtgaagtacc     3960

tcagatccct gagttctcac gtttacagtt tcatctcaaa aataagaagc aaaccacata     4020

agtataggag aggtaaatta agtgggggca aggcagtagt ggacagggtt ggaaactgca     4080

ctggaaaata gggaacatgt gtatgtcata aggaaggcaa tgcagcccat ccctacctgg     4140

aatgctggga agtgctaggc agggctgctc tcagcaagac tgcagcagct gcacccagac     4200

ctggggctct ggtaggtact aatggtgatt atgctccaat ttacctaatg aatttggtgg     4260

gacagcagaa aagaaagctg ggaatgtacc aagagaaatt tttgttcagg gctgttggaa     4320

gtagctgtta gccttgcttc cacaaggcca ttgctgctgt aataagaact gcaaatcaga     4380

gtgctacaac ataaaactgg gaaatatggc cctatctgaa tgcctctgtc ctattttccg     4440

ctggtgtatc agttagtgca ggaagtaaag aatgctggaa agttgaatca gaaattgaaa     4500

accttctaaa atcttacaca gattagcaga agtcacttct cccagtctgg tatattattt     4560

cataatggac caggatcggc ttcctgcctg ttggtggcta tctgtaaacc ataagtacag     4620

gggtctccct agtggttctt ctctgtcttt tgctgggcag gctgtcttcc tttattcctg     4680

gtagcattca gagcattaac cagtgttgat tttgaaaata gtagtcccta caggttctca     4740

caaaggaatg aatcctgttc tgatacagtt cccctgcata ctgacatact ggccaaggac     4800

ttgagcagct gtgtattttt ctttatcaac taaaatacca gggagatggt cttttcttga     4860

aacccagtgg cctgtatgtg actgagagga aaagctggct tggtcctaat ggctgtttct     4920

ctgtaccttt cccttccctt accaccttaa gcccaatcca ggtagagaat agggagaggc     4980

attctcctct ctatggattt gaagtgaatc acccccacat tattctcaca tgcttttctt     5040

ctctcacata ttcctcccta ctcccccacc caatcattgt gcttatttgt acagatctta     5100

ttgggaatat tctttattta ttttgtcatt tcacttctat tttaagaatg cataattgaa     5160

ggagtagtca ttttcaggga gcaccaggta gaccctggga acctaatgac ttaatcctta     5220

aatatgtttt gcccttgaaa aataggcctt ttccttcctt ccttagttat aattgtggaa     5280

gctaattagg atggcatgga agtgaatcta atgagttagg tattattaat gttcttggta     5340

tcgggtctaa ttccagttac tgcttcattc tctttttaaa gctttatgaa tacttccccc     5400

atcctcccca aggagagctc aatacacaca tatttttatt ttattctctc aaaggaatat     5460

tagcttagga agataggaat tcaacattga gcactgagtt ttcttctggc tctgtcattg     5520

atacactgtc aaaccacagc ctcatctctt aatctattta attaaggtaa cagtacatgt     5580

tctcaagggt gttgcaagta agtgtgcagc tatcccttgg agagcctctc tggaaagctc     5640

ttttagtgca gtgttgttat gctgaattgt tttccattat cttatttgct gagtagaaaa     5700

tattaatgaa attaagaatt gttgagatta tatgaattgg gctagaatac taaggggaaa     5760

actatgtttt gaatagagtt tggcattttt gaccaagaac aaaattgagt tttcattgga     5820

aagaaaggaa accttgattc ttaccattgc tgctccaaag gaggcccagg ttaagaggat     5880

tagaggagac acgcggtgct gggcattcct ggcaggtgtt gggtgatccc cgcagtatgt     5940

cacctgcagt tgcagcacag gcagctagtg attgggttca tctcctccta gtggttggaa     6000

gagaactcag atgtaaaaac cagcggtcct tctcccacct tctttcctgc cattcttgct     6060

catcatacat gtccgtaaac ttgaagaact cgttttagca gctagccttt taaggtcgag     6120

gatgggaaag ctaaaactgt agaatattat tatgctgctt tttaggttta tccctgttgt     6180

tgtgggatgc aagttaaggg attgtaattg tttttcaggg tttttttgtt ttttgttttt     6240

taagcaaggg ctctattttc ccttgagagt tctggaacta agccttggag aaacactact     6300

gagtgtattt aggctccctg gttttcttgc ccaacaacaa tctgaagggt agggggtggg     6360

ggctgtgtct tactcagggg cagcacctag ctgtcttgcc tacagtgggt gcacgatata     6420

taaatggaat tgatttttgt caacactgtc aagagtggca ttgactattg gagcataccc     6480

cgtccacatg atgcttgaac tatgtaactt caggggttga gggctcaagg ttcaggttaa     6540

agaggcactg tcaacttact atacaagcat aatttaggtt tttccttttt ctacttgaaa     6600

aggaccagct taaacacaaa cccttatgta aattaaaagg tttgaatcca aagcagagag     6660

aactgcttct ggaaaagtgt agtttaattt taactattct aaaagcaatg agcaaaggcc     6720

cttgtccaag gcgttgacag ttttctaaag tggttatgct gtatatctgg atgcatgcct     6780

ttgggctgcc actgcttgat tcctttcatg tacagataat attacttcag tttagatttc     6840

ccactttaaa atgcagtgat ttgtgttgaa tacatcttga ttgtgcttta cctaaagtat     6900

tttcttaaaa ggctttgtgt aaaatttaaa tgtatatatt ttcctgtaga cttccatcat     6960

gattttcaga gattagcctt aaaaaatttg gccctaagaa attcattcag tgtttttcta     7020

gatgacctct gtacatagag gtcattatag tggagaccct ttaccagcag cattttaaga     7080

tttaaattag atagaaagtt tcttaggatt caactgaaaa ttggctagta aaatatgtcc     7140

caggtaataa agcatgctga ctttgctaag gcactgccca tttttattta actaaagtca     7200

tggagatttt gagtttaaag gatgcagtat agatagtggt ttagtgttta ggctctaatg     7260

ccagtctaaa aggcaagtca tttaaccttg ggagcctcag tttcctcact gtaaaacagg     7320

gataataata gtaactacct cagggttgtt gtaaggatta aatgagatga tatttgtaag     7380

atacttagct caagtgcctg gcacacaatg agcacactct ataaatgttc tactactact     7440

attattaaca cctagtctag ggatgcacag cagaatcccc tagggttaaa aaacaaaaca     7500

aaacaaacaa aaaaaactga cggaatagcc ccactccaga tcagaattcc cagtgggctg     7560

gggtctcggc cagtgtattc tccagtaatc tcgccaggtg tttgaaacac ccagtgctat     7620

ctgaaaacta tcagtacccc aaccctttgg tttatagatt aagaaactag cagaagatgg     7680

ttaaattact tgcctattgt ctcagaacgg ttaattagtg gcggagccaa ggctagaatt     7740

caagtctctt gactttatgg ttgtggggtc tttccaccat acctgctgcc atgtgagaca     7800

ctgcaaaaaa gtggctcaga ccgacaatca gcctgtgtgg tgctgcacac tttctaaagc     7860

acatgctcct gacactttga ccttaagggg cttgaatgtg gagtaatggg aacacaagcc     7920

aagcaagcac tcagtagaat tcagtcattt aaaaaattca atggggtcat tcttttggac     7980

agacctcagc aacacagcaa tgtgcacttt gtagtaaaga aataccaact tgagttttta     8040

aaaaacctag ttagtcctac attccctttt ctttaaaaaa actttattgt tcacattatt     8100

ttaatgacta tgagataatg tatatgacag cactttgaga aaatatcaac tgtaatataa     8160

ctataaggtt gtagtattgt ctgtttaaaa gataagacag ttgattcaat gtggatggac     8220

cctgtggggt acctgaaaat gtagatacgt aagaatcacc tctgtcattt atcacattta     8280

gaaatatgaa actgcttaac aggtatgagc aggtatagca agtgtttgct aaagttgtag     8340

ttcagagctg aattacttca ggaaactagg gaccaacttt ttggtttaat tccgatcttt     8400

aaaaagtaag aatgtgtact cactccagaa cacagaagct cttccaagga ccttgactca     8460

agaaggatga ggtcctctta ctcttctcca tttatccact atatgcttgg ccatttatcc     8520

taaatgtggt gggaacagac ttgttatctg ttgatgttga cagtgtcttt tttaacctat     8580

gtcctgcata gttttgttag gtttacaggg ggaggtggat ggccataaaa ccagtgcact     8640

ttgggaatta cttttctagg atttcctacc agttataaat gacattgaca tttgtcatct     8700

tttttttctt tttctaaaaa gaatagctga atttaattca cctattataa aatactcaaa     8760

agtaaattgc cttggtggcc acttctgaat tatagctaca tttcattatg accccttctg     8820

ctcccttcca ttttgctact gatgtcattc ttgttatcag gctgtgcccc taccaggagt     8880

tcatattggg ttgacagggt tatctatatt tttgttcttg atttttgagt ttcatcatct     8940

tgcattaaat tgttccacct ggatttgggg ttcatctctg tgccctaagg atctgctatg     9000

accaatcctc tttttgtagg tgggtctctg gcttaagtat tgataggctt cagcggtttg     9060

tgtctctgtc ttagcttgta tcaagccagt agtagctcac ttcctttgta aattcctgct     9120

tcagtctggg atccgtagga gtatgtgaga acttctgaaa cgtctccaac tcttaacagt     9180

caagatatct atatcatttg gatagagttc tggttttcca actactagac ttaaagaaat     9240

tctggccggg tgcggtggct cacgcctgta atcccagcac tttggggggc tgaggcgggt     9300

ggatcacgag gtcaggagat tgagaccatc ctggctaaca cggtgaaacc ccacctctac     9360

taaaaataca aaaacttagc tgggcgtggt ggcgggcgcc tgtagtccca gctactgggg     9420

aggctgaggc aggagaatgg cgtgaaccca ggaggcggag cttgcagtga gcccagatcg     9480

cgccactgca ctccagcctg ggtgacagtg agactccgtc tcaaaaaaaa aaaaaaaaaa     9540

aaaaaaaaaa aaaaaaagaa attctaatgc aaagcttgct ttttttttct tttttccagc     9600

aagccagtag taatagttat tgttacttgc tctgttcagc acaactgtag ttcacttgaa     9660

cttcactgtc attccctacg ctcctctctt actgagaagc atgggtggga ttcagggctg     9720

tgggacaagc tacagcctac tctggagcac tcacccccat gactcagtcc agcctgtctc     9780

ttgggaagtt tattgcaatg tgcagacgga tgaatttctg cttttcatgc cacctctctg     9840

aggtatgtat tctatcttga gtatgtacaa gatgatacct tttggctggg cacagtggct     9900

cgtgcctgta atcccagcac tttgggagac caagatgggc ggatcacttg aggtcaggag     9960

tttgagacca gcctggccaa catggtgaaa ccccgtctct actaaaaata taaaaattag    10020

ccgggcgtag tacatgcctg taatcccagc tactcccgag gctgaggcag aattgcttga    10080

acccaggagg cggaggttgc agtgagctga gatcgcgccg ctgcactcca gcctaagtga    10140

cagagtgaga cacgttaaga agaaaaaaaa aaaaaaggat accttcattt ctgactcaat    10200

atcctagatc caaaggacag gaaattaggg aaggcttcac cctgtgggat caagataaga    10260

agatcccata cttcttccca ggtaaggagg cctgtggcag gtcatgattc aaagctgact    10320

tggaatggca gaaactgctg agaggccacc cttggagatt tgtgccttca aagatgggtt    10380

tcatgagtct cagagaggaa aagacttgtc agctgggttg attttgcatg attattgaac    10440

tagagctggt agacacgagc ttctcagatg gcagtggcca gatcctccat ctgtgagaat    10500

ccgccacttg aagtggtttc ctgagagtgt tcacttggca gttgctgcgt ttctcaagcc    10560

cacctggcga ggtctcgccg gacccttccc tccaagtgca cttacttctt catccccatg    10620

tacatctcta actttgaaat tgtttacctc tcctacaaaa atcttacctt ttgacctgag    10680

cagagtagca aagccctgtt cactctgagg gagcagctgg cgtgttgaag gggaaaggcc    10740

aggcacagca ctgtcctcag accacaccat atttggagca gaattgtgat acatgtcatc    10800

tgtgtctatt ctggaaggtt ctttgttcat cactgtactc gcatcagcaa attttcaggg    10860

tcctacctgt cactccaggc tactgagctg aaccctcaga agctgaggtc tccgagcatg    10920

ctaagtaacc ttttagaaaa gctggaggca aactgtcgaa tgctagcagg ctttatgaaa    10980

ggaaacataa ggagtttgtg tagtcagaac ttgcttaaat ttgcttcgga attaggcacc    11040

ataaacttta gttggagaat gggacttaaa ttttcacata tatgtatact taattttcag    11100

caattatgac acaataaaaa gaatatgcaa atttattgtt gtttcagaag gttttgcagg    11160

actgggaacg ctttagtgtc atcaacagta aacctcagat actgttctgc acagttcaga    11220

agtaccatac caggtattgt gagtggcaag aacgccaggg gacagagatg cttctggtag    11280

atgagggcca gagaaaccag ctctcctcca ttttgacagc aatttctcac tgtggccatt    11340

tggcctccat tatgttttga gaggaatttc ttgagatctt gagaaatcac catgattagg    11400

ccaattgtca atcagtattc agaaactaga aaggaacaat gagatacttg tttatggttc    11460

tttagggcat atgtttgaaa accctctcat ctcagatctg tatagctggt gtgtgtttgt    11520

gtccataaat acacgtgcat tgctgtcgtg cccattaaga aagggggagt aagtaaaaga    11580

ggaatcgctc agatctttcc ttggatgaac agcagtggcg tggttggtgt gttgactgtg    11640

aacaggctga cttagctgtt gatgtatact cagaacctcc atctcctccc agaccctgca    11700

cttttccttc tctgcagtct gattctctaa tgactgtcac tggacaaacc ccagttttat    11760

gctcgcttag taaaaataag tttaaacatt tcatggtggt tgacagaact ttgtccccaa    11820

acatgcggat tcaattcttt aaaactcgtt gaacgtttat accaaaggtc ccgccccgca    11880

ggtgtgtatg tggtgcacag agggtgaggt ttggagcatc gggcactgtg tgcattgcta    11940

aggggacata gtgagacaat gtgggattta actaaaaaca catcaattgt gtgtcacatt    12000

accagtgttg tcaggtattt gttcttaatt gttattgtaa tatattttca gttgtttttc    12060

taatttaatt ctctccgtct gttgtctgac tgtgaactgc taacagtgtt aaacttgatg    12120

taaataaatg aggcccttga aagggactgc tttctctgtc ttctcacaag gtttgccaag    12180

ttgtgttctg ttttaaataa aggttgcaat attttattgg caaagtaaaa aaaaaaaaaa    12240

aaaa                                                                 12244


<210>  84
<211>  1561
<212>  DNA
<213>  Homo sapiens

<400>  84
gcggcgcgga gggcgcgggc ccgggagcca gggagcgagc ggggcgcccg gcagcgcgga       60

gtcagcgccg cgggggccgc acccgactcg cgcctggaca ctcgcggggc gccgacctgg      120

cagggggcca aaccagtgct cctgccacct ctctggctgc cccctagagc ctgcccatcc      180

cagcctgacc aatgtccaca gccagggagc agccaatctt cagcacacgg gcgcacgtgt      240

tccaaattga cccagccacc aagcgaaact ggatcccagc gggcaagcac gcactcactg      300

tctcctattt ctacgatgcc acccgcaatg tgtaccgcat catcagcatc ggaggcgcca      360

aggccatcat caacagcact gtcactccca acatgacctt caccaaaact tcccagaagt      420

tcgggcagtg ggccgacagt cgcgccaaca cagtctacgg cttgggcttt gcctctgaac      480

agcatctgac acagtttgcc gagaagttcc aggaagtgaa ggaagcagcc aggctggcca      540

gggagaaatc tcaggatggc ggggagctca ccagtccagc cctggggctc gcctcccacc      600

aggtgccccc gagccctctc gtcagtgcca acggccccgg cgaggaaaaa ctgttccgca      660

gccagagcgc tgatgccccc ggccccacag agcgcgagcg gctaaagaag atgttgtctg      720

agggctccgt gggcgaggta cagtgggagg ccgagttttt cgcactgcag gacagcaaca      780

acaagctggc aggcgccctg cgagaggcca acgccgccgc agcccagtgg aggcagcagc      840

tggaggctca gcgtgcagag gccgagcggc tgcggcagcg ggtggctgag ctggaggctc      900

aggcagcttc agaggtgacc cccaccggtg agaaggaggg gctgggccag ggccagtcgc      960

tggaacagct ggaagctctg gtgcaaacca aggaccagga gattcagacc ctgaagagtc     1020

agactggggg gccccgcgag gccctggagg ctgccgagcg tgaggagact cagcagaagg     1080

tgcaggacct ggagacccgc aatgcggagt tggagcacca gctgcgggcg atggagcgca     1140

gcctggagga ggcacgggca gagcgggagc gggcgcgggc tgaggtgggc cgggcagcgc     1200

agctgctgga cgtcaggctg tttgagctga gtgagctgcg tgagggcctg gcccgcctgg     1260

ctgaggctgc gccctgagcc ggggctggtt ttctatgaac gattccggcc tgggatgcgg     1320

gccaggctgc aggcggcata gttgggccca ttcgtcctgg aaagggactg gggggtccca     1380

acttagccct gggtgggccg ggccgggctg ggctggggtg ggccccagtc ggctctggtt     1440

gttggcagct ttggggctgt ttttgagctt ctcattgtgt agaatttcta gatcccccga     1500

ttacatttct aagcgtgaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa     1560

a                                                                     1561


<210>  85
<211>  1834
<212>  DNA
<213>  Homo sapiens

<400>  85
atttttagat aatcattaaa gaccacagaa aatgtaacag atcctactct tcaaaataat       60

tgctattcag tattaaaacg agcagtcagc tgcgtgattc ccgtgattgc gttacaagct      120

ttgtctcctt cgacttggag tctttgtcca ggacgatgag acactcaaag agaacttact      180

gtcctgattg ggatgacaag gattgggatt atggaaaatg gaggagcagc agcagtcata      240

aaagaaggaa gagatcacat agcagtgccc aggagaacaa gcgctgcaaa tacaatcact      300

ctaaaatgtg tgatagccat tatttggaaa gcaggtctat aaatgagaaa gattatcata      360

gtcgacgcta cattgatgag tacagaaatg actacactca aggatgtgaa cctggacatc      420

gccaaagaga ccatgaaagc cggtatcaga accatagtag caagtcttct ggtagaagtg      480

gaagaagtag ttataaaagc aaacacagga ttcaccacag tacttcacat cgtcgttcac      540

atgggaagag tcaccgaagg aaaagaacca ggagtgtaga ggatgatgag gagggtcacc      600

tgatctgtca gagtggagac gtactaagtg caagatatga aattgttgat actttaggtg      660

aaggagcttt tggaaaagtt gtggagtgca tcgatcataa agcgggaggt agacatgtag      720

cagtaaaaat agttaaaaat gtggatagat actgtgaagc tgctcgctca gaaatacaag      780

ttctggaaca tctgaataca acagacccca acagtacttt ccgctgtgtc cagatgttgg      840

aatggtttga gcatcatggt cacatttgca ttgtttttga actattggga cttagtactt      900

acgacttcat taaagaaaat ggttttctac catttcgact ggatcatatc agaaagatgg      960

catatcagat atgcaagtct gtgaattttt tgcacagtaa taagttgact cacacagact     1020

taaagcctga aaacatctta tttgtgcagt ctgactacac agaggcgtat aatcccaaaa     1080

taaaacgtga tgaacgcacc ttaataaatc cagatattaa agttgtagac tttggtagtg     1140

caacatatga tgacgaacat cacagtacat tggtatctac aagacattat agagcacctg     1200

aagttatttt agccctaggg tggtcccaac catgtgatgt ctggagcata ggatgcattc     1260

ttattgaata ctatcttggg tttaccgtat ttccaacaca cgatagtaag gagcatttag     1320

caatgatgga aaggattctt ggacctctac caaaacatat gatacagaaa accaggaaac     1380

gtaaatattt tcaccacgat cgattagact gggatgaaca cagttctgcc ggcagatatg     1440

tttcaagagc ctgtaaacct ctgaaggaat ttatgctttc tcaagatgtt gaacatgagc     1500

gtctctttga cctcattcag aaaatgttgg agtatgatcc agccaaaaga attactctca     1560

gagaagcctt aaagcatcct ttctttgacc ttctgaagaa aagtatatag atctgtaatt     1620

ggacagctct ctcgaagaga tcttacagac tgtatcagtc taatttttaa attttaagtt     1680

attttgtaca gctttgtaaa ttcttaacat ttttatattg ccatgtttat tttgtttggg     1740

taatttggtt cattaagtac atagctaagg taatgaacat ctttttcagt aattgtaaag     1800

tgatttattc agaataaatt ttttgtgctt atga                                 1834


<210>  86
<211>  4304
<212>  DNA
<213>  Homo sapiens

<400>  86
gtcgcgggca gctggcgccg cgcggtcctg ctctgccggt cgcacggacg caccggcggg       60

ccgccggccg gagggacggg gcgggagctg ggcccgcgga cagcgagccg gagcgggagc      120

cgcgcgtagc gagccgggct ccggcgctcg ccagtctccc gagcggcgcc cgcctcccgc      180

cggtgcccgc gccgggccgt ggggggcagc atgcccgcgc gcgctgcctg aggacgccgc      240

ggcccccgcc cccgccatgg gcgcccctgc ctgcgccctc gcgctctgcg tggccgtggc      300

catcgtggcc ggcgcctcct cggagtcctt ggggacggag cagcgcgtcg tggggcgagc      360

ggcagaagtc ccgggcccag agcccggcca gcaggagcag ttggtcttcg gcagcgggga      420

tgctgtggag ctgagctgtc ccccgcccgg gggtggtccc atggggccca ctgtctgggt      480

caaggatggc acagggctgg tgccctcgga gcgtgtcctg gtggggcccc agcggctgca      540

ggtgctgaat gcctcccacg aggactccgg ggcctacagc tgccggcagc ggctcacgca      600

gcgcgtactg tgccacttca gtgtgcgggt gacagacgct ccatcctcgg gagatgacga      660

agacggggag gacgaggctg aggacacagg tgtggacaca ggggcccctt actggacacg      720

gcccgagcgg atggacaaga agctgctggc cgtgccggcc gccaacaccg tccgcttccg      780

ctgcccagcc gctggcaacc ccactccctc catctcctgg ctgaagaacg gcagggagtt      840

ccgcggcgag caccgcattg gaggcatcaa gctgcggcat cagcagtgga gcctggtcat      900

ggaaagcgtg gtgccctcgg accgcggcaa ctacacctgc gtcgtggaga acaagtttgg      960

cagcatccgg cagacgtaca cgctggacgt gctggagcgc tccccgcacc ggcccatcct     1020

gcaggcgggg ctgccggcca accagacggc ggtgctgggc agcgacgtgg agttccactg     1080

caaggtgtac agtgacgcac agccccacat ccagtggctc aagcacgtgg aggtgaatgg     1140

cagcaaggtg ggcccggacg gcacacccta cgttaccgtg ctcaagacgg cgggcgctaa     1200

caccaccgac aaggagctag aggttctctc cttgcacaac gtcacctttg aggacgccgg     1260

ggagtacacc tgcctggcgg gcaattctat tgggttttct catcactctg cgtggctggt     1320

ggtgctgcca gccgaggagg agctggtgga ggctgacgag gcgggcagtg tgtatgcagg     1380

catcctcagc tacggggtgg gcttcttcct gttcatcctg gtggtggcgg ctgtgacgct     1440

ctgccgcctg cgcagccccc ccaagaaagg cctgggctcc cccaccgtgc acaagatctc     1500

ccgcttcccg ctcaagcgac aggtgtccct ggagtccaac gcgtccatga gctccaacac     1560

accactggtg cgcatcgcaa ggctgtcctc aggggagggc cccacgctgg ccaatgtctc     1620

cgagctcgag ctgcctgccg accccaaatg ggagctgtct cgggcccggc tgaccctggg     1680

caagcccctt ggggagggct gcttcggcca ggtggtcatg gcggaggcca tcggcattga     1740

caaggaccgg gccgccaagc ctgtcaccgt agccgtgaag atgctgaaag acgatgccac     1800

tgacaaggac ctgtcggacc tggtgtctga gatggagatg atgaagatga tcgggaaaca     1860

caaaaacatc atcaacctgc tgggcgcctg cacgcagggc gggcccctgt acgtgctggt     1920

ggagtacgcg gccaagggta acctgcggga gtttctgcgg gcgcggcggc ccccgggcct     1980

ggactactcc ttcgacacct gcaagccgcc cgaggagcag ctcaccttca aggacctggt     2040

gtcctgtgcc taccaggtgg cccggggcat ggagtacttg gcctcccaga agtgcatcca     2100

cagggacctg gctgcccgca atgtgctggt gaccgaggac aacgtgatga agatcgcaga     2160

cttcgggctg gcccgggacg tgcacaacct cgactactac aagaagacaa ccaacggccg     2220

gctgcccgtg aagtggatgg cgcctgaggc cttgtttgac cgagtctaca ctcaccagag     2280

tgacgtctgg tcctttgggg tcctgctctg ggagatcttc acgctggggg gctccccgta     2340

ccccggcatc cctgtggagg agctcttcaa gctgctgaag gagggccacc gcatggacaa     2400

gcccgccaac tgcacacacg acctgtacat gatcatgcgg gagtgctggc atgccgcgcc     2460

ctcccagagg cccaccttca agcagctggt ggaggacctg gaccgtgtcc ttaccgtgac     2520

gtccaccgac gagtacctgg acctgtcggc gcctttcgag cagtactccc cgggtggcca     2580

ggacaccccc agctccagct cctcagggga cgactccgtg tttgcccacg acctgctgcc     2640

cccggcccca cccagcagtg ggggctcgcg gacgtgaagg gccactggtc cccaacaatg     2700

tgaggggtcc ctagcagccc accctgctgc tggtgcacag ccactccccg gcatgagact     2760

cagtgcagat ggagagacag ctacacagag ctttggtctg tgtgtgtgtg tgtgcgtgtg     2820

tgtgtgtgtg tgtgcacatc cgcgtgtgcc tgtgtgcgtg cgcatcttgc ctccaggtgc     2880

agaggtaccc tgggtgtccc cgctgctgtg caacggtctc ctgactggtg ctgcagcacc     2940

gaggggcctt tgttctgggg ggacccagtg cagaatgtaa gtgggcccac ccggtgggac     3000

ccccgtgggg cagggagctg ggcccgacat ggctccggcc tctgcctttg caccacggga     3060

catcacaggg tgggcctcgg cccctcccac acccaaagct gagcctgcag ggaagcccca     3120

catgtccagc accttgtgcc tggggtgtta gtggcaccgc ctccccacct ccaggctttc     3180

ccacttccca ccctgcccct cagagactga aattacgggt acctgaagat gggagccttt     3240

accttttatg caaaaggttt attccggaaa ctagtgtaca tttctataaa tagatgctgt     3300

gtatatggta tatatacata tatatatata acatatatgg aagaggaaaa ggctggtaca     3360

acggaggcct gcgaccctgg gggcacagga ggcaggcatg gccctgggcg gggcgtgggg     3420

gggcgtggag ggaggcccca gggggtctca cccatgcaag cagaggacca gggccttttc     3480

tggcaccgca gttttgtttt aaaactggac ctgtatattt gtaaagctat ttatgggccc     3540

ctggcactct tgttcccaca ccccaacact tccagcattt agctggccac atggcggaga     3600

gttttaattt ttaacttatt gacaaccgag aaggtttatc ccgccgatag agggacggcc     3660

aagaatgtac gtccagcctg ccccggagct ggaggatccc ctccaagcct aaaaggttgt     3720

taatagttgg aggtgattcc agtgaagata ttttatttcc tttgtccttt ttcaggagaa     3780

ttagatttct ataggatttt tctttaggag atttattttt tggacttcaa agcaagctgg     3840

tattttcata caaattcttc taattgctgt gtgtcccagg cagggagacg gtttccaggg     3900

aggggccggc cctgtgtgca ggttccgatg ttattagatg ttacaagttt atatatatct     3960

atatatataa tttattgagt ttttacaaga tgtatttgtt gtagacttaa cacttcttac     4020

gcaatgcttc tagagtttta tagcctggac tgctaccttt caaagcttgg agggaagccg     4080

tgaattcagt tggttcgttc tgtactgtta ctgggccctg agtctgggca gctgtccctt     4140

gcttgcctgc agggccatgg ctcagggtgg tctcttcttg gggcccagtg catggtggcc     4200

agaggtgtca cccaaaccgg caggtgcgat tttgttaacc cagcgacgaa ctttccgaaa     4260

aataaagaca cctggttgct aacctggaaa aaaaaaaaaa aaaa                      4304


<210>  87
<211>  2984
<212>  DNA
<213>  Homo sapiens

<400>  87
ggcacgaggg acgtgttcgt cttttcctac tcttgccaag agggagaaac caaggagctc       60

tggtcatcag gtcaccatct caaggcctgc cgagctgtgg ccttctctga agatgggcag      120

aagctcatta ctgtctccaa ggacaaagcc atccatgttc tagatgtgga gcagggccaa      180

ctggaaagac gtgtttccaa ggctcatggt gcccccatca atagtcttct gctggtggat      240

gagaatgttc tggccactgg ggatgacaca ggtggtatcc gtctctggga ccagcggaag      300

gagggcccct taatggatat gaggcaacat gaagagtaca tcgcagacat ggctctggat      360

ccagccaaaa agctgctgct gacagccagc ggggatggct gccttggcat cttcaacatt      420

aagaggcgtc ggtttgagct gctctcagaa cctcagtctg gggacctgac ctctgtcact      480

ctcatgaaat gggggaagaa ggtagcctgt ggctccagtg aaggtaccat ctacctcttc      540

aattggaatg gctttggggc cacaagtgac cgctttgccc tgagagctga atctatcgac      600

tgcatggttc cagtcaccga gagtctgctg tgtactggct ccactgatgg agtcatcagg      660

gctgtgaaca tcctaccgaa ccgagtggtg ggcagtgtgg gccagcacac tggggagcct      720

gtggaggagc tggccctctc ccactgtggc cgcttcctgg ccagtagtgg ccatgaccag      780

cgcctcaagt tttgggacat ggcccagctg cgagctgtgg tggtggatga ctaccgtcgg      840

cgcaaaaaaa agggaggacc actgcgggct ctgagcagca agacttggag caccgatgac      900

ttcttcgcag gactgaggga agagggagaa gactccatgg ctcaggaaga aaaggaggag      960

actggggatg acagtgactg aaggaatgaa ttgaatcttg agacgggtcc tcaccagccc     1020

cagcagacca caggaggttg gccccagact cactgagtgc ctgcagcagc cgtacagaca     1080

cagcatcctt ggccacctca tgcccatccc ggccatctag ggtcagcaca acccagatga     1140

ggccgctgaa gggcaccgga tgcccaggaa tcaccacctg gtaccagaag cggtgccagc     1200

cagcaggtcc tatgcccaaa cacttgctat gctcagtata aagtgccggg cagaacgcgt     1260

ttggccccaa ccagcacccc cgccccagcc taccttccac cagggccttt ttggccatgg     1320

cagcggcccg gtgcgagctg aatttgagca gagcgatctg cccgggcgcc ggtccggggc     1380

tgggcagcag ccgcgcctcc tgcaagccgg gacccagcgg ctgcagcgcg agcagcagcg     1440

cgctgcgggt cagattcggc ggcaggccgt caacgctcag ctcacacttc tcggtgctgc     1500

ggcacacgag cagcgggcag gacggccgca gcggatggtt gtgcagcgtg gcgatggcgg     1560

cctgcgcgcc gcgcctcgag ctgtagcggg cataggcgaa gccgcggttc aggccgctga     1620

aggtcatcat caggcggaac tcgtagaggc ggcccacgcg ctggaacagc gggataagct     1680

ggtgctcgta cacgtcctga ggcagccgcc cgatgaacac ctctgaccca gctggcggcg     1740

ggctgctcac ccagcctgtg ggaagagggt atgcaaggcc accgtcaggc gacgctttcg     1800

aattctgagc ccacggaccc agcgcgcggg ggtgaggcga tgtgaacaaa ggtctgtgaa     1860

atgggtttac acccgtaccc tgggtggttg gcataattag gtgactgcgc taacaagggg     1920

gctggcacag agtaggtaca ccttgagatt ggccccctcc ctcgacgggg cgggtggacg     1980

tggagccaca gttcctcctt tgctgggggg tataaatccg ggtagttcgc agtttctgac     2040

agtgaaggct cggagcagcc cctcccccaa agggggctgg tgtagccgga caggcggagg     2100

ggctgggact accgtacctg ggggtggccc gccatacttc ctctgcccgt tcacctgcac     2160

caggcggatg cctgtctccc tgacccacgc ctccagcgcc gccttgttct ctggattcac     2220

cctctcacac cacagctgag agggaaagga aggttggaat ggcggatcgc caagcgcgcc     2280

cccacctctc ctgtggtact ggggtcccta aagccgaccc ccgctccggc ggggctcgcc     2340

ggcccccaag tcgccagccg cttacctcac aatcccgctt ggactgcatg gctctccagc     2400

tggccccctc gtaccctctt tataacttcc tccccaccgg cctctggaag cttccctacc     2460

cctccacccc gcaagctctc attggctctg agcgcgaccc cgcctcccag gggggtggag     2520

gtatccactg cacgtgcgcc gcccgggctt cgctcagacc ttcaggtgaa agctgcaaag     2580

tcgcgggtgc gtatgtacgg gggctgcctc ccgaggagga gctcccaagc cgcagggtgg     2640

acgctggaga caagaacctc agggtcacaa gtttactgtt tttctccctt ttccatccct     2700

acattggtct gctggggaag gcggggctag gcatcactga cacacgcaga ctccgtggtt     2760

gaggcatttt attggacctt tggcaattgg tggtggggag gcatctgctc caactggtgc     2820

ggggccctgc agatgggacc atctcaggct gggtccttgt agcccaggag cacagactgg     2880

actaagcctc ctgggccttg tatgaaaaag gtgttgtacc tggccgtttt tgccagtaat     2940

aatcaataaa ataaccataa taaaaaaaaa aaaaaaaaaa aaaa                      2984


<210>  88
<211>  2179
<212>  DNA
<213>  Homo sapiens

<400>  88
ggcacgaggg tcatggacct cctgcacaag aacatgaaac acctgtggtt cttcctcctc       60

ctggtggcag ctcccagatg ggtcctgtcc caggtgcagc tacagcagtg gggcgcagga      120

ctgttgaagc cttcggagac cctgtccctc acctgcggtg tttatggtgg gtccttcagt      180

ggttactatt ggagctggat tcgccagccc ccagggaagg ggctggagtg gattggggaa      240

atcaatcata gtggaagcac caactacaac ccgtccctca agagtcgagt caccatatca      300

gtagacacgt ccaagaagca gctctccctg aagttgagct ctgtgaacgc cgcggacacg      360

gctgtgtatt actgtgcgag agttattact agggcgagtc ctggcacaga cgggaggtac      420

ggtatggacg tctggggcca agggaccacg gtcaccgtct cctcagggag tgcatccgcc      480

ccaacccttt tccccctcgt ctcctgtgag aattccccgt cggatacgag cagcgtggcc      540

gttggctgcc tcgcacagga cttccttccc gactccatca ctttctcctg gaaatacaag      600

aacaactctg acatcagcag cacccggggc ttcccatcag tcctgagagg gggcaagtac      660

gcagccacct cacaggtgct gctgccttcc aaggacgtca tgcagggcac agacgaacac      720

gtggtgtgca aagtccagca ccccaacggc aacaaagaaa agaacgtgcc tcttccagtg      780

attgccgagc tgcctcccaa agtgagcgtc ttcgtcccac cccgcgacgg cttcttcggc      840

aacccccgca agtccaagct catctgccag gccacgggtt tcagtccccg gcagattcag      900

gtgtcctggc tgcgcgaggg gaagcaggtg gggtctggcg tcaccacgga ccaggtgcag      960

gctgaggcca aagagtctgg gcccacgacc tacaaggtga ccagcacact gaccatcaaa     1020

gagagcgact ggctcagcca gagcatgttc acctgccgcg tggatcacag gggcctgacc     1080

ttccagcaga atgcgtcctc catgtgtgtc cccgatcaag acacagccat ccgggtcttc     1140

gccatccccc catcctttgc cagcatcttc ctcaccaagt ccaccaagtt gacctgcctg     1200

gtcacagacc tgaccaccta tgacagcgtg accatctcct ggacccgcca gaatggcgaa     1260

gctgtgaaaa cccacaccaa catctccgag agccacccca atgccacttt cagcgccgtg     1320

ggtgaggcca gcatctgcga ggatgactgg aattccgggg agaggttcac gtgcaccgtg     1380

acccacacag acctgccctc gccactgaag cagaccatct cccggcccaa gggggtggcc     1440

ctgcacaggc ccgatgtcta cttgctgcca ccagcccggg agcagctgaa cctgcgggag     1500

tcggccacca tcacgtgcct ggtgacgggc ttctctcccg cggacgtctt cgtgcagtgg     1560

atgcagaggg ggcagccctt gtccccggag aagtatgtga ccagcgcccc aatgcctgag     1620

ccccaggccc caggccggta cttcgcccac agcatcctga ccgtgtccga agaggaatgg     1680

aacacggggg agacctacac ctgcgtggtg gcccatgagg ccctgcccaa cagggtcacc     1740

gagaggaccg tggacaagtc caccgagggg gaggtgagcg ccgacgagga gggctttgag     1800

aacctgtggg ccaccgcctc caccttcatc gtcctcttcc tcctgagcct cttctacagt     1860

accaccgtca ccttgttcaa ggtgaaatga tcccaacaga agaacatcgg agaccagaga     1920

gaggaactca aaggggcgca gcctccgggt ctggggtcct ggcctgcgtg gcctgttggc     1980

acgtgtttct cttccccgcc cggcctccag ttgtgtgctc tcacacaggc ttccttctcg     2040

accggcaggg gctggctggc ttgcaggcca cgaggtgggc tctaccccac actgctttgc     2100

tgtgtatacg cttgttgccc tgaaataaat atgcacattt tatccatgaa aaaaaaaaaa     2160

aaaaaaaaaa aaaaaaaaa                                                  2179


<210>  89
<211>  1356
<212>  DNA
<213>  Homo sapiens

<400>  89
gccggggccg gcggtgccgg ggtcatcggg atgatgcgga cgcagtgtct gctggggctg       60

cgcgcgttcg tggccttcgc cgccaagctc tggagcttct tcatttacct tttgcggagg      120

cagatccgca cggtaattca gtaccaaact gttcgatatg atatcctccc cttatctcct      180

gtgtcccgga atcggctagc ccaggtgaag aggaagatcc tggtgctgga tctggatgag      240

acacttattc actcccacca tgatggggtc ctgaggccca cagtccggcc tggtacgcct      300

cctgacttca tcctcaaggt ggtaatagac aaacatcctg tccggttttt tgtacataag      360

aggccccatg tggatttctt cctggaagtg gtgagccagt ggtacgagct ggtggtgttt      420

acagcaagca tggagatcta tggctctgct gtggcagata aactggacaa tagcagaagc      480

attcttaaga ggagatatta cagacagcac tgcactttgg agttgggcag ctacatcaag      540

gacctctctg tggtccacag tgacctctcc agcattgtga tcctggataa ctccccaggg      600

gcttacagga gccatccaga caatgccatc cccatcaaat cctggttcag tgaccccagc      660

gacacagccc ttctcaacct gctcccaatg ctggatgccc tcaggttcac cgctgatgtt      720

cgttccgtgc tgagccgaaa ccttcaccaa catcggctct ggtgacagct gctccccctc      780

cacctgagtt ggggtggggg ggaaagggag ggcgagccct tgggatgccg tctgatgccc      840

tgtccaatgt gaggactgcc tgggcagggt ctgcccctcc cacccctctc tgccctggga      900

gccctacact ccacttggag tctggatgga cacatgggcc aggggctctg aagcagcctc      960

actcttaact tcgtgttcac actccatgga aaccccagac tgggacacag gcggaagcct     1020

aggagagccg aatcagtgtt tgtgaagagg caggactggc cagagtgaca gacatacggt     1080

gatccaggag gctcaaagag aagccaagtc agctttgttg tgatttgatt ttttttaaaa     1140

aactcttgta caaaactgat ctaattcttc actcctgctc caagggctgg gctgtgggtg     1200

ggatactggg attttgggcc actggatttt ccctaaattt gtcccccctt tactctccct     1260

ctatttttct ctccttagac tccctcagac ctgtaaccag ctttgtgtct tttttccttt     1320

tctctctttt aaaccatgca ttataacttt gaaacc                               1356


<210>  90
<211>  934
<212>  DNA
<213>  Homo sapiens

<400>  90
gggctgcgga gaggcgggcc gggccaagcg gagccaagcg agcgggagcg cggcgtccgg       60

gaggcggcgg agacgcgggg ctcggagggt cagcctctta tcgtagcagg tctcctcggc      120

acgcccccct tgtttcgccc cacggccaag cccgccgcgg gccggcgtgc gctggtcact      180

gaggcccagg tcgccgccgc ggcgcgtttt tgaaatcatg aatcctgttt atagtcctgg      240

atcttctggg gttccctatg caaatgccaa aggaattggt tatccagctg gttttcccat      300

gggctatgca gcagcagctc ctgcctattc tcctaacatg tatcctggag cgaatcctac      360

cttccaaaca ggttacactc ctggcacacc ttacaaagtg tcctgttccc ccaccagcgg      420

ggctgtgcca ccgtactcct cctcaccaca ggctgtgccc atgagtccct gtgcagacca      480

gtgggcaagg cagctgggcc agatctcagg ccagccgttt gtgctcctag cagggttgct      540

gtgctggcca cacggagagg ccctagagag cctcatggat tgtaactaaa gaagaaacgg      600

ttcctttttg tttttttaaa aatgattttt aaataccgtt ttttacaccg ttctctcggt      660

acttttttta agctaagtca gcattgtctt ccagtgttaa aggcatccct cacctctgca      720

ttgaacttac gtatccatgc caaggaatgg aatttccatc ctgagccagt tcagttaggt      780

gtcaattgat actattttaa ttttttatgc aatctgatga gatgagctca gatttaaaaa      840

tctcaaaagc acgtttattg taacaagaat tgttatgtat taatactgca gttttcaata      900

aagattgact tgtgttgcaa aaaaaaaaaa aaaa                                  934


<210>  91
<211>  2898
<212>  DNA
<213>  Homo sapiens

<400>  91
agtgtaaggg agtgggagct ggtccgtgcc gcggcggccg cgcagggagc tctcgaggca       60

acgccggggc gcccgaggtc tggaaggcgc agaaatggag caagagccac aaaatggaga      120

acctgctgaa attaagatca tcagagaagc atataagaag gcctttttat ttgttaacaa      180

aggtctgaat acagatgaat taggtcagaa ggaagaagca aagaactact ataagcaagg      240

aataggacac ctgctcagag ggatcagcat ttcatcaaaa gagtctgaac acacaggtac      300

tgggtgggaa tctgctagac agatgcaaca gaaaatgaaa gaaactctac agaatgtacg      360

caccaggctg gaaattctag agaagggtct tgccacttct ctgcagaatg atcttcagga      420

ggtgcccaag ttatatccag aatttccacc taaagacatg tgtgaaaaat taccagagcc      480

tcagtctttt agttcagctc ctcagcatgc tgaagtaaat ggaaacacct caactccaag      540

tgcaggggca gttgctgcac ctgcttctct gtctttacca tcacaaagtt gtccagcaga      600

agctcctcct gcttatactc ctcaagctgc tgaaggtcac tacactgtat cctatggaac      660

agattctggg gagttttcat cagttggaga ggagttttat aggaatcatt ctcagccacc      720

gcctcttgag accttagggc tggatgcaga tgaattgatt ttgataccaa atggagtaca      780

gatttttttt gtaaatcctg caggggaggt tagtgcacct tcgtatcctg ggtaccttcg      840

aattgtgagg tttttggata attctctcga tacggttcta aaccgtcctc ccgggtttct      900

tcaggtttgt gactggttat atcctctagt tcctgataga tctccggttc tgaaatgtac      960

tgcgggagcc tacatgtttc ctgatacaat gctacaagca gcaggatgct ttgtgggggt     1020

cgtcctgtcc tctgagttac cagaggatga tagagagctc tttgaggatc tgttaaggca     1080

aatgtctgac cttcggctcc aggccaactg gaacagagca gaagaagaaa atgaattcca     1140

aatccctgga agaactagac cctcctctga ccaactaaaa gaagcctctg gcactgatgt     1200

gaaacagttg gaccaaggca ataaggatgt acgtcataaa ggaaaacgtg gaaaaagggc     1260

taaagatact tcaagtgaag aagttaacct gagtcacatt gtaccatgtg agccagttcc     1320

agaagaaaag ccaaaagaat tacatgaatg gagtgaaaaa gtggctcaca acattttgtc     1380

aggtgcttcc tgggtgagtt ggggtttagt caaaggtgct gagattactg gtaaggcaat     1440

ccagaaaggt gcttctaaac tccgagagcg gattcaacca gaagaaaaac ccgtggaagt     1500

tagtccagct gtcaccaagg gactttatat agcgaagcaa gctacaggag gagcagcaaa     1560

agtcagtcag ttcctggttg atggagtttg cactgtagca aattgcgttg gaaaagaact     1620

agctccacat gtcaagaagc atggaagcaa acttgttcca gaatctctta aaaaagacaa     1680

agatgggaaa tctcctctgg atggtgctat ggttgtagca gcgagtagtg ttcaaggatt     1740

ttcaactgtc tggcaaggat tggaatgtgc agctaaatgc atcgttaaca atgtttcagc     1800

agaaactgta caaactgtca gatacaaata cggatataat gcaggagaag ctacccacca     1860

tgcggtggat tctgcggtca atgttggcgt aactgcctac aatattaaca acattggtat     1920

caaagcaatg gtgaagaaaa ctgcaacaca aacaggacac actctccttg aggactatca     1980

gatagttgat aattctcaga gggaaaatca agaaggagca gcaaatgtca acgtgagagg     2040

ggagaaggat gagcagacga aggaagtaaa ggaggcaaag aagaaagata aatgatgaag     2100

tgctgggaat cacttatacc aaagccttat gaaatggatg aaattttgtt aaataggcaa     2160

atgtggaatt cctcacagat taaccagtat tttttaaatg tattcattcc tacaaattaa     2220

ctttcataaa ttttatggca tgtcttctat ttaaaaggaa aagaataagt attcttgcat     2280

ctggccttag aaatgtgaag ttatattctc aagtttattt ttttccaagt gtagctaaaa     2340

tatttttgca ggtaaaataa agctgatagt acatgtgttg ttcaaacctt gttaaaccta     2400

atattgaact atttttatat ctgctgtctt tcagaaggca aataggaaac tatatatttg     2460

cttaaaaatt ggcatttagt aaccttaatt ctttttatag aaggaatgac ttaaagtatt     2520

gtcccctctt tttgcactaa ttgtggattt ttttagatgc ttctcaaaat tttcagtgtg     2580

taagctaaac aaaaactaaa actaagaatt ctcaaaaaga cttgttcaaa acagggaaag     2640

actgatgaaa agtaaaatgg actacttttg taacttacct gtttgttagg aaatggaatg     2700

gtttctttga tttaaaatga ataaaaatag attattacgt cttttgtatt gagactgtat     2760

tgttatgagc ctaggaaatt tgggaacatg attgtattgt attaaaattc gaagtgatta     2820

ttatcagctt aattggatta aaaaagtact tcaagaaatt aaaaaaaaaa aaaaaaaaaa     2880

aataaaaaaa aaaaaaaa                                                   2898


<210>  92
<211>  2598
<212>  DNA
<213>  Homo sapiens

<400>  92
gacccagcgc cgagcccgag ccatggcgtc cgagcggctc cctaacaggc ccgcctgtct       60

gctcgtggcc agcggcgccg ccgaaggtgt gtcggcccag tccttcctcc actgtttcac      120

gatggccagc accgccttca acctgcaggt ggccacccct ggggggaaag ccatggaatt      180

tgtggatgtg actgagagca atgcacgctg ggtgcaagac ttccgcctca aggcttacgc      240

cagccccgcc aagctcgagt ccatcgatgg tgcccggtac catgccctcc tgatccccag      300

ctgtcctggg gccctgaccg acctggccag cagtggctcc ctggcccgta tcctgcagca      360

cttccactct gagagcaaac ccatctgcgc cgtcggccac ggtgtcgccg ccctgtgctg      420

tgccaccaac gaggacagat cctgggtgtt cgacagctac agcctgacag ggccctccgt      480

gtgtgagctc gtcagggccc ccggcttcgc ccgcctgccg ctcgtggtgg aggacttcgt      540

gaaggattcg ggcgcctgct tcagtgcaag cgagcctgac gctgtccacg tcgtgctgga      600

ccgccacctg gtcacaggcc agaatgccag ctccactgtc ccggccgtgc agaacctgct      660

cttcctctgt ggcagccgga aatgaacctg ctgggtagat gcaccccctg agacagccca      720

ggtgtctcca gaggcagccc cgtctcaggc ttcagggacc ccgcctcttc cctcctgaca      780

agggccctgg atggcagcct ggtctggccc tgatgggatt gttggaggcc tcctggaatc      840

agctctgagg gggtgtcggc tctcctggag ggtccaaacc cccatcctcc tgcatgttct      900

ctggtaggag gcagagaaaa gaccccacgt gcctggagag ctgtgctagc tgctaggtgg      960

tcctcgggaa ttccaggctg ggttttctag ggaggactgg ttgtcacgtg tggtcactgt     1020

tgactagaca gagtcggctc gggggtcctc tgtgtgggtt tgccctgctg tggcctgtct     1080

gccacccacc acctctttca ctgttggtgg gggccttgag gggagggccc agccggcggg     1140

agctggctca gaactttggc caaaggtgaa cggaattttt taggagcagc agcctcctgc     1200

cccaaggccg accggcactg gcagcacttt cctgttgaag aaatcttcct ggcgtgtggt     1260

ttcaaagtgt aagcacctca gtgatgcacc ctgtcctaag cattgagagg cacgtttact     1320

tgtgaatatg agaccatgag attctcaatg ataggaaagt gctgtccccc acggccttgc     1380

acagtggcct cgggtagagc ggctatcaag agcagacagt ggtccagcct gctgggcacc     1440

tggcctgggc tgtggccctc cagcgggctg ccccctggcc ccaggttagg gcgtccagga     1500

gaggcttagg ccctctactt cctcacagtt ccccagtttg agccatcgaa ggccttcttc     1560

ctgcccacct ccccgtctca gccacagccg ttcccaagca ccagcgtggc tcctggtgcc     1620

agtgacctgc caggaggccc cttgtgatta taaaaccgtt cagttgggcc gggcgcagtg     1680

gctcacgcct gtaaccccgg cactttggga ggccgaggcg ggcggatcgc ggggtcagga     1740

ggtcgagacc atcctggcta acatggtgaa accccatctc tactaaaaaa caaaaataca     1800

aaaagttagc ctggcatggt ggtgggtgtg tgtggtccca gctacttggg aggctgaggc     1860

aggagaatcg cttgaacccg ggaggcggag gttgcggtga gctgacatcg tgccactgca     1920

ctctagtctg ggtgacagag cgggactcca tctcaaaaaa aaaaagaagg aaaatattgt     1980

aagcctagtg gcttataaac aacagaaatc agtttcagtt ttggaggctg gaagcccaag     2040

atgaaagcac cagtagatgc aacctctttt gtaagggtga tggtcccatg atgaggctgt     2100

gcccctgccc tgtgaccgga tgacctccca aatgccccac ctaataccat ccccttgcag     2160

gtgaggactt aagcaggtgg gttttggggg gacgtgctca ggccacagca gggtgcatga     2220

agagccagtg agcctcattg agcccctctg gtcagccaga tctgacattg agcccagcat     2280

tgaagatcaa agcaggtggg gctttgggat gtgaagtggg ttctgacgcg gggccccaca     2340

gacctgtctc cgcgtgagct gcctgcaggc ccctgcgtca ttcctcagct gcgtgcgagg     2400

cctctggctt ggagagcctc cccgctgtgc acagttctct ctttgccagg gcagggcttg     2460

gggcagcacc aggctggggc agaggaggaa agcaagagga cagacctcca gaagagcagc     2520

ggagggcggg tgaggatttc cccatatacc agtgtgtgtt catctaccca tgaggaataa     2580

aaccatgcag cagcatgc                                                   2598


<210>  93
<211>  1578
<212>  DNA
<213>  Homo sapiens

<400>  93
ggcacgaggg ggaggtgacg cgcgctgccg gggcgaggtt gcgaggggcg gtgttgaaga       60

atgtgtgggc gaacatcctg tcacttacct agagatgttc tcacgagagc ttgcgcctac      120

caggatcggc ggggccagca gcggctcccg gagtggaggg accctgataa gtactgcccc      180

tcttacaaca agagtcctca atccaacagc ccagtgcttc tgtctcgact gcactttgag      240

aaggatgcag actcatctga gcgtatcatt gctcccatgc gctggggctt ggtcccttct      300

tggttcaaag aaagtgatcc ttccaagctg cagttcaata ctaccaactg tcgtagtgat      360

accgtaatgg agaaacggtc atttaaggtg cctctgggaa agggaagacg ctgtgtcgtt      420

ttagcagatg gattctatga gtggcagcga tgtcagggaa caaaccagag gcagccatac      480

ttcatctatt ttcctcaaat caagacagag aagtcaggta gcattggtgc tgcagatagt      540

cctgagaact gggagaaagt ctgggacaac tggaggctgc tgacaatggc cgggatcttt      600

gactgctggg agcccccaga gggaggagat gtcctgtatt cctataccat catcacagtg      660

gattcctgca aaggcttgag tgacatccac cacaggatgc ctgccatatt agatggagag      720

gaggcagttt ctaaatggct tgactttggt gaagtctcaa ctcaggaagc tctgaaatta      780

atccacccaa cagagaacat caccttccat gcagtctctt ctgtggtgaa caactcgcga      840

aacaacactc ctgagtgtct ggctcctgtc gacttggtgg tcaaaaagga gctcagggca      900

agtggcagta gccagaggat gttgcagtgg ttggccacaa agtcacccaa aaaggaagac      960

tcaaaaacac ctcaaaagga agagtcagat gttccccagt ggtccagtca gttcctgcag     1020

aagagtccac tccccaccaa gagaggcact gcaggactcc tagagcaatg gctgaagcgg     1080

gagaaggagg aggaacctgt ggccaagcgt ccttacagcc agtgacacag gactttcaga     1140

gaccaaggcc agggtctgct gcactgctgt tctgataata ggttcttaac attgtatgta     1200

tatgtgtttg ctttgggagg aggtggcact gtgttagttg acagttgtgg gctcatgtag     1260

tcttttttgc catgagtagg agcccctagt ggggctggtg gacagctttg gaagaggtgt     1320

cctgctgctg ttaccagcca tgtgggcccc ataggggcac tgcgcctgct gccctttcct     1380

ggcagggctg gtggagtctt ccctcaaagc atgccttacc cagctgggaa gtctctgccc     1440

tgatctggta ctccttgtag taagctgttt tctgctcagc cactgggctc tttcactttt     1500

ttagttctta aaaatttatt tttaagttct aaaataaaat aaaaataagt tcttaaaaaa     1560

aaaaaaaaaa aaaaaaaa                                                   1578


<210>  94
<211>  1270
<212>  DNA
<213>  Homo sapiens

<400>  94
gtgaaactct gaaagtccct cccaaaaaga tggaagattt aactaatgta tcaagtctac       60

tgaatatgga aagggcacga gacaaagcta atgaagaagg tctggcatta ctacaggaag      120

aaatagataa aatggtagag accacagagt taatgactgg gaatattcag agcctaaaga      180

acaaaattca gattctggca agtgaggtgg aagaagaaga ggagagagta aaacagatgc      240

atcaaataaa tagtagtgga gtactctctc ttccggaact ttctcagaaa actctcaaag      300

cacccacact tcagaaagaa attttggcgc taattccaaa ccagaatgct cttctaaagg      360

acttggatat tcttcataat tcatcacaga tgaagagcat gtcaaccttc attgaagaag      420

cctataagaa actggatgca tcttaaagag tgtttttttt ttagattgtt ccatattaat      480

ttaatgttcg tgaatttgta aaactgttaa cctatgatta tatgtacaga ggctaaggct      540

tctgcaggat ttattatctc ctgatatgca ctttaaaatt agtctttgta gttctatcat      600

tagcatctaa tgtagttctg aagactgttt ttagcagttg ccaaatctag gaaactaaca      660

tttatattgc tgtatctata agtatttgcc taaaaccata aaataggaat tgccttaagg      720

atctaatagt ttataatgcc tgaatggaac tcatttattg gttaacagct catatcagga      780

gctgtgataa gtaagtgttt acatacactg tctagtgcat aaaaacctta gtgtttgcta      840

tcattcattc tgtagccaat ggcttacagt ttctgtctgg tcatctggaa cttgaaaaat      900

cctcaaatgc cttcactctt ttacctaact ccctagtctt tttgggaagt agttaagata      960

tgcctgctat ctttaacttt ggaggtagta tcaaaatttt acttctttgg ttgtttagtg     1020

aattaatgtt gaatattttc tactgtcatc aaaacatatt cccaaaaagt attaaaaagg     1080

aaccttagca catttatttt attaaaacaa gaaaacccaa aatatataaa ccttttctta     1140

ttatgataat aagcttatat atgtgaataa gttataacct agtgtataaa aaattatttc     1200

taacaaacta cagtatactg tcttgggttt tttttttttt tttagtctgt aaaataaaat     1260

gactgcaatt                                                            1270


<210>  95
<211>  2454
<212>  DNA
<213>  Homo sapiens

<400>  95
ggcacgagga ggagagtcag gccaatgggg ccgcagttct ttcttttttt tttctttatt       60

cttatttttg gagacagggt ctcgctctgt tgcccaggct ggagtgcggt ggtgcgatca      120

cggttccatg cagcccccga cctcccgggc tcaggtgatt ctcccgcctc agcaccgcga      180

gcagctagga ccacaggcgc gagccactgc gtccggccgg cgggacttat ttgtcaggcg      240

gggattgggt tccgccagcc taaagggagg ggtaagcgcc agaatatgaa tcgccgggaa      300

gctgggagaa agctccggga aaccctgagc agccaggtcg cctgctccgc ccgctcccgc      360

tcccgatctc tgattgctcc taactgacgt cactcccggt ctgtccccgc ccactcggtg      420

ctgccattgg cagtcggtcg tgggtctgag agtcactgga gctaccagaa gcatcatggg      480

gccctgggga gagccagagc tcctggtgtg gcgccccgag gcggtagctt cagagcctcc      540

agtgcctgtg gggctggagg tgaagttggg ggccctggtg ctgctgctgg tgctcaccct      600

cctctgcagc ctggtgccca tctgtgtgct gcgccggcca ggagctaacc atgaaggctc      660

agcttcccgc cagaaagccc tgagcctagt aagctgtttc gcggggggcg tctttttggc      720

cacttgtctc ctggacctgc tgcctgacta cctggctgcc atagatgagg ccctggcagc      780

cttgcacgtg acgctccagt tcccactgca agagttcatc ctggccatgg gcttcttcct      840

ggtcctggtg atggagcaga tcacactggc ttacaaggag cagtcagggc cgtcacctct      900

ggaggaaaca agggctctgc tgggaacagt gaatggtggg ccgcagcatt ggcatgatgg      960

gccaggggtc ccacaggcga gtggagcccc agcaaccccc tcagccttgc gtgcctgtgt     1020

actggtgttc tccctggccc tccactccgt gttcgagggg ctggcggtag ggctgcagcg     1080

agaccgggct cgggccatgg agctgtgcct ggctttgctg ctccacaagg gcatcctggc     1140

tgtcagcctg tccctgcggc tgttgcagag ccaccttagg gcacaggtgg tggctggctg     1200

tgggatcctc ttctcatgca tgacacctct aggcatcggg ctgggtgcag ctctggcaga     1260

gtcggcagga cctctgcacc agctggccca gtctgtgcta gagggcatgg cagctggcac     1320

ctttctctat atcacctttc tggaaatcct gccccaggag ctggccagtt ctgagcaaag     1380

gatcctcaag gtcattctgc tcctagcagg ctttgccctg ctcactggcc tgctcttcat     1440

ccaaatctag ggggcttcaa gagaggggca ggggagattg atgatcaggt gcccctgttc     1500

tcccttccct cccccagttg tggggaatag gaaggaaagg ggaagggaaa tactgaggac     1560

caaaaagttc tctgggagct aaagatagag cctttggggc tatctgacta atgagaggga     1620

agtgggcaga caagaggctg gccccagtcc caaggaacaa gagatggtca agtcgctaga     1680

gacatatcag gggacattag gattggggaa gacacttgac tgctagaatc agaggttgga     1740

cactatacat aaggacaggc tcacatggga ggctggaggt gggtacccag ctgctgtgga     1800

acgggtatgg acaggtcata aacctagagt cagtgtcctg ttggtcctag cccatttcag     1860

caccctgcca cttggagtgg acccctccta ctcttcttag cgcctaccct catacctatc     1920

tccctcctcc catctcctag gggactggcg ccaaatggtc tctccctgcc aattttggta     1980

tcttctctgg cctctccagt cctgcttact cctctatttt taaagtgcca aacaaatccc     2040

cttcctcttt ctcaaagcac agtaatgtgg cactgagccc tacccagcac ctcagtgaag     2100

ggggcctgct tgctctttat tttggtcccg gatcctgggg tggggcagaa atattttctg     2160

ggctggggta ggaggaaggt tgttgcagcc atctactgct gctgtaccct aggaatatgg     2220

ggacatggac atggtgtccc atgcccagat gataaacact gagctgccaa aacatttttt     2280

taaatacacc cgaggagccc aagggggaag ggcaatgcct acccccagcg ttatttttgg     2340

ggagggaggg ctgtgcatag ggacatattc tttagaatct attttattaa ctgacctgtt     2400

ttgggacctg ttacccaaat aaaagatgtt tctagaaaaa aaaaaaaaaa aaaa           2454


<210>  96
<211>  2527
<212>  DNA
<213>  Homo sapiens

<400>  96
gaacagcgaa gacagcgtga gcctgggccg ttgcctcgag gctctcgccc ggcttctctt       60

gccgacccgc cacgtttgtt tggatttaat cttcaggttg ccggcgcccg cccgcccgct      120

ggcctcgcgg tgtgagaggg aagcacccgt gcctgtggct ggtggctggc gcctggaggg      180

tccgcacacc cgcccggccg cgccgcttgc ccgcggcagc cgcgtccctg aaccgcggag      240

tcgtgtttgt gtttgacccg cgggcgccgg tggcgcgcgg ccgaggccgg tgtcggcggg      300

gcggggcggt cgcggcggag gcagaggaag agggagcggg agctctgcga ggccgggcgc      360

cgccatggaa ctgggcccgg agcccccgca ccgccgccgc ctgctcttcg cctgcagccc      420

ccctcccgcg tcgcagcccg tcgtgaaggc gctatttggc gcttcagccg ccgggggact      480

gtcgcctgtc accaacctga ccgtcactat ggaccagctg cagggtctgg gcagtgatta      540

tgagcaacca ctggaggtga agaacaacag taatctgcag agaatgggct cctccgagtc      600

aacagattca ggtttctgtc tagattctcc tgggccattg gacagtaaag aaaaccttga      660

aaatcctatg agaagaatac attccctacc tcagaagctg ttgggatgta gtccagctct      720

gaagaggagc cattctgatt ctcttgacca tgacatcttt cagctcatcg acccagatga      780

gaacaaggaa aatgaagcct ttgagtttaa gaagccagta agacctgtat ctcgtggctg      840

cctgcactct catggactcc aggagggtaa agatctcttc acacagaggc agaactctgc      900

cccagctcgg atgctttcct caaatgaaag agatagcagt gaaccaggga atttcattcc      960

tctttttaca ccccagtcac ctgtgacagc cactttgtct gatgaggatg atggcttcgt     1020

ggaccttctc gatggagaga atctgaagaa tgaggaggag accccctcgt gcatggcaag     1080

cctctggaca gctcctctcg tcatgagaac tacaaacctt gacaaccgat gcaagctgtt     1140

tgactcccct tccctgtgta gctccagcac tcggtcagtg ttgaagagac cagaacgatc     1200

tcaagaggag tctccacctg gaagtacaaa gaggaggaag agcatgtctg gggccagccc     1260

caaagagtca actaatccag agaaggccca tgagactctt catcagtctt tatccctggc     1320

atcttccccc aaaggaacca ttgagaacat tttggacaat gacccaaggg accttatagg     1380

agacttctcc aagggttatc tctttcatac agttgctggg aaacatcagg atttaaaata     1440

catctctcca gaaattatgg catctgtttt gaatggcaag tttgccaacc tcattaaaga     1500

gtttgttatc atcgactgtc gatacccata tgaatacgag ggaggccaca tcaagggtgc     1560

agtgaacttg cacatggaag aagaggttga agacttctta ttgaagaagc ccattgtacc     1620

tactgatggc aagcgtgtca ttgttgtgtt tcactgcgag ttttcttctg agagaggtcc     1680

ccgcatgtgc cggtatgtga gagagagaga tcgcctgggt aatgaatacc ccaaactcca     1740

ctaccctgag ctgtatgtcc tgaagggggg atacaaggag ttctttatga aatgccagtc     1800

ttactgtgag ccccctagct accggcccat gcaccacgag gactttaaag aagacctgaa     1860

gaagttccgc accaagagcc ggacctgggc aggggagaag agcaagaggg agatgtacag     1920

tcgtctgaag aagctctgag ggcggcagga ccagccagca gcagcccaag cttccctcca     1980

tcccccttta ccctctttgc tgcagagaaa cttaagcaaa ggggacagct gtgtgacatt     2040

tggagagggg gcctgggact tccatgcctt aaacctacct cccacactcc caaggttgga     2100

gcccagggca tcttgctggc tacgcctctt ctgtccctgt tagacgtcct ccgtccatat     2160

cagaactgtg ccacaatgca gttctgagca ccgtgtcaag ctgctctgag ccacagtggg     2220

atgaaccagc cggggcctta tcgggctcca gccatctcat gaggggagag gagacggagg     2280

ggagtagaga agttacacag aaatgctgct ggccaaatag caaagacaac ctgggaagga     2340

aaggtctttg tgggataatc catatgttta atttattcaa cttcatcaat cactttattt     2400

tatttttttt tctaactcct ggagacttat tttactgctt cattaggttg aaatactgcc     2460

attctaggta gggttttatt atcccaggga ctacctcggc ttttaattta aaaaaaaaaa     2520

aaaaaaa                                                               2527


<210>  97
<211>  3053
<212>  DNA
<213>  Homo sapiens

<400>  97
gcgatggcgg agagtccgac tgaggaggcg gcaacggcgg gcgccggggc ggcgggcccc       60

ggggcgagca gcgttgctgg tgttgttggc gttagcggca gcggcggcgg gttcgggccg      120

cctttcctgc cggatgtgtg ggcggcggcg gcggcagcgg gcggggccgg gggcccgggg      180

agcggcctgg ctccgctgcc cgggctcccg ccctcagccg ctgcccacgg ggccgcgctg      240

cttagccact gggaccccac gctcagctcc gactgggacg gcgagcgcac cgcgccgcag      300

tgtctactcc ggatcaagcg ggatatcatg tccatttata aggagcctcc tccaggaatg      360

ttcgttgtac ctgatactgt tgacatgact aagattcatg cattgatcac aggcccattt      420

gacactcctt atgaaggggg tttcttcctg ttcgtgtttc ggtgtccgcc cgactatccc      480

atccacccac ctcgggtcaa actgatgaca acgggcaata acacagtgag gtttaacccc      540

aacttctacc gcaatgggaa agtctgcttg agtattctag gtacatggac tggacctgcc      600

tggagcccag cccagagcat ctcctcagtg ctcatctcta tccagtccct gatgactgag      660

aacccctatc acaatgagcc cggctttgaa caggagagac atccaggaga cagcaaaaac      720

tataatgaat gtatccggca cgagaccatc agagttgcag tctgtgacat gatggaagga      780

aagtgtccct gtcctgaacc cctacgaggg gtgatggaga agtcctttct ggagtattac      840

gacttctatg aggtggcctg caaagatcgc ctgcaccttc aaggccaaac tatgcaggac      900

ccttttggag agaagcgggg ccactttgac taccagtccc tcttgatgcg cctgggactg      960

atacgtcaga aagtgctgga gaggctccat aatgagaatg cagaaatgga ctctgatagc     1020

agttcatctg ggacagagac agaccttcat gggagcctga gggtttagac cctgctccca     1080

tctccccttc ccccactcaa gagtcccagc agaatccctt ccccccaccc cagggatgga     1140

gaggcactgt gtatctccct ccagactcga agtcatcctg caagatggca agaaccaagc     1200

aagctccgat cccagggtgt gggagtgggg gcctgttccc ggtctgacct ccttggcact     1260

ggagcatctg gggcttcgtt catccattca tcccgtatca ggggccaagg tacctttaca     1320

ggagcaccta gagcgagggc ctttggcaaa aacaaaacaa ccaacacacc tctccacagg     1380

gccagctcct tagggataag tggaagatgg aaattgcaat tccaagaggg agtgtgccca     1440

aatgatttat ggggatacct ggaagggagc ttggggtggg ggctgtctgt gacacttaag     1500

cagtctgggt ggttgtctat ttgtctgtct tcagtcttga agcagggctt cccaatgccc     1560

ttttcctccc tgccttcctt cccccattat ttcccacagg ccagcataat tttgtttttc     1620

ctaatttata gtcactgttc tagacagacc aaagagaagg aacagtggtg gagtctaggc     1680

tgctgatcag taagctttac ctagcacctg agcacctttc tcccctcccc tctttcctca     1740

cccttttcta gatgtaagac agaaggtaaa tgtgactggg acttaaccaa ggtcttggta     1800

aagcctgcat ggcaccgtaa gaagctgaaa atactgtttg ttcccgcaat cactgatttg     1860

aaaagttccc aacacaggca gctgctgtgt atatgggatt agagccacta catagaatag     1920

tctcttacag attttcataa atactagtca caataagggt atttttcttg ggggtggagt     1980

aagggggaga ctgatgctag tccttgttgt attttgttgg gctgtccttg tgtattttca     2040

ccccagcctg tagtcctcct cacttcaacc ccagggattt gtggggagca agggtagcca     2100

atggcagagg gggttggggc tgggactctg gaggctcctc cccttctttc tcttccttct     2160

gcctcccccg tgcccccagc tgctcttgtc actgtctctg atgggtattt gcctggcttt     2220

gttgcttctc tatctgtatt tagctgcagt gatcctttag ctggttggct cagaaaaaaa     2280

aaaatgtgct ttaggtgccc tgtaatcctg ggcatcaagg gaatccatcc ttcccctttt     2340

tgatatgttc tccccgtact tccagattta ttgttatggc tcccagtggg tattggcgat     2400

tcttgtgatg cagggcctca gtcagtgtcc agccatgcat aagggagagg atagtgtgta     2460

cctgccctgc cctctgctat gaaggtctct gccttgtgga tcatgggact ccccttggag     2520

gatctgtgca aaggggggct gggcacaaag gagaatgtcc tatttgggag ggcaggaagc     2580

aaaggaactg gacagggatt ggtgggcttg gggaacggaa gtttatcttg gatacccttg     2640

aagaggctgg gtctcttcac atgaagatcg aaaagggacc ctgcttccaa tttccctctt     2700

ccattcctcg agctactcca gggcttagaa gaatgctctt ggtctgtggg tccagtgttg     2760

tctgtcatcc atttaagtgt tcccactttc aagtgacaat cctctccttg gccctgccat     2820

agggcagagc atgtctggca tagcagcctg acttttatgc cctaatcttg agttgaggaa     2880

atatatgcac aggagtcaaa gagatgtctt tatatctgac tgtatataaa tgaagttttt     2940

ttgttttttt tgttttcctt tttggtgcaa taaagtttgt tttggcagaa aaaaaaaaaa     3000

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaa            3053


<210>  98
<211>  1554
<212>  DNA
<213>  Homo sapiens

<400>  98
gccgtttctg ccgcgtccac cacaacctct gctgtatcag agggggcctt cgccgccgcc       60

gcccccacca ccgcccctgc cgccatcgcc acctccgccg ctgccgcctt ggggccctcc      120

tccttcaccg cccccttcac cacctctaca cgttctaggc cttctgtcct ggagaagaag      180

ctatagtcgt tctcccttgt gggcccgggg cgcagccatg gcggacggcg gcggcggcgg      240

gggaactggc gcggtgggcg gcggcggaac tagccaggcc tctgccgggg cagcgactgg      300

cgctactggg gccagcgggg gcggtggccc catcaacccg gcctcgctgc ctcccggcga      360

cccgcagctc atcgctctca tcgtggagca gctcaagagc cggggccttt ttgacagctt      420

ccgccgggac tgcctggccg acgtggacac caagccagct taccaaaacc tgaggcagaa      480

agtggataat tttgtgtcaa cacatctgga caagcaggaa tggaatccta cgatgaacaa      540

aaaccagttg cgaaatggtc tgaggcagag tgtggttcag tcagggatgt tggaagctgg      600

agtagacagg attatttctc aggtggtgga tccaaaactt aaccacatct tcaggccaca      660

aatagaacga gcaattcatg agttcctggc ggcccagaaa aaagcagctg tgccagcacc      720

ccctccagag cccgaaggcc aggaccctcc agctccatct caggacactt cctaagaata      780

cgccagacac cttttgaaag ctaatttttg gtgaagaaat ggattcggtt acataagagt      840

gcaacttcag actgaagata ggccaaggtc gtcactgatc tcaagatttc aaccttgacc      900

atgggcagtg accagattga aaggggagca agttcggcag tgggagagtt gaccgtgtca      960

ccccctgcat tgtgctgcca tttggccagc ctgtccaagg gcatgacacc aagtagacac     1020

tacagagaga gaaacactac agcaacccag ggttgtcctg aaacagactt ttatacttga     1080

acatggagac tgcacatgga ctttagggtt tgtgctgtgg gataaacgga agctacagtg     1140

agaacatagc cagtcccaaa gacaatttca aagaaaaatg acagtaaaga ttagctggga     1200

gtagtctttg acagtgctta tttgatactg tctctcagag tttgcaaacc agattgtaca     1260

agtcattagc gtcagatagc tttaaagttg tgaccttctt gtacatgaat cttctagcca     1320

gtttcctttc ctttgtaacg aaacatgaaa tcctagaatg tatgagaagt tcagacatta     1380

ggcataagga aactcgtttg caggctctct gtccagggct gcttcctgtc ctggaggggc     1440

cagtgagtct taggtatgtt tattttattc tcacatttgt gtttttttag aaaagtgaat     1500

ggtcaataaa tggcttatct ttcataataa aaaaaaaaaa aaaaaaaaaa aaaa           1554


<210>  99
<211>  726
<212>  DNA
<213>  Homo sapiens

<400>  99
tccgtttccg gccgaggctg cggccatggc agcatcttcc ctgacggtca ccttagggcg       60

gctggcgtcc gcgtgcagcc acagcatcct gagaccttcg gggcccggag cagcctccct      120

ttggtctgct tctcgaaggt tcaattcaca gagcacttca tatctaccag ggtaatatca      180

aaatatatgt tcctaaaaca tccctgagtt caccaccttg gccagaagtt gttctgccag      240

acccagttga ggagaccaga caccatgcag aggtcgtgaa gaaggtgaat gagatgatcg      300

tcacggggca gtatggcagg ctctttgccg tggtgcactt tgccagccgc cagtggaagg      360

tgacctctga agacctgatc ttaattggaa atgaactaga ccttgcgtgt ggagagagaa      420

ttcgactgga gaaggtcctg ctggttgggg cagacaactt cacgctgctt ggcaagccac      480

tcctcggaaa ggatcttgtt cgagtagaag ccacagtcat tgaaaagaca gaatcatggc      540

caagaatcat tatgagattc aggaaaagga aaaacttcaa gaagaaaaga atcgtcacga      600

ccccgcagac tgtcctccgg ataaacagca ttgagattgc tccgtgtttg ttgtgattac      660

cgagttaata cttacaaaag gataaaaata aactcctgct tcccaaggaa aaaaaaaaaa      720

aaaaaa                                                                 726


<210>  100
<211>  2296
<212>  DNA
<213>  Homo sapiens

<400>  100
gggggcaagt gtcagtcagg acgggagtcc ggcgggttac agcggaggcc taggtggcag       60

acagggggcc cgggccgctg cgtgttgtcc acccaagatg gagttcctcc tggggaaccc      120

gttcagcaca ccagtggggc agtgcctcga aaaggcaaca gatggctccc tgcaaagtga      180

ggattggacg ttgaatatgg agatctgtga catcatcaat gagacggagg aagggccaaa      240

ggatgccatt cgagccctga agaagcggct caacgggaac cggaactaca gagaggtgat      300

gctggcatta acagcatggg ctgatgcctt tcgaagcagt cctgatctca ccggcgttgt      360

gcacatatat gaggagctga agaggaaagg ggttgaattt cccatggcag acttggacgc      420

tctgtctccc atacacacac cacagcggag tgtccctgaa gtggatccag ctgcgaccat      480

gcccaggtcc caatcacagc agaggacaag tgctggttcc tattcctcgc cgcctcctgc      540

tccctactcc gcaccgcagg ccccagctct gagtgtgact ggccccatca cagccaattc      600

agaacagatt gccaggctgc ggagtgaact ggacgtcgtt cgaggaaaca caaaagtcat      660

gtctgagatg ttaacagaaa tggtccctgg acaggaggat tcatctgatc tggagttgct      720

gcaggagctc aacaggacct gtcgggccat gcagcagcgc atcgtggagc tcatctcccg      780

cgtgtccaat gaggaggtca ccgaggagct gctgcatgtg aacgatgacc tcaacaacgt      840

cttccttcga tacgagaggt tcgaacgata caggtctggc cgatccgttc aaaatgccag      900

taatggagta ctgaatgaag taaccgaaga caacttaata gacctggggc cagggtctcc      960

agccgtggtg agcccaatgg tggggaacac agcgccccca tcttccctct cctcccagct     1020

tgcaggctta gacttgggga cagagagcgt cagtggcacc ctcagttcac tccagcaatg     1080

taatccccgt gacggctttg acatgtttgc ccagacgaga ggaaactcct tggctgagca     1140

gcgcaagacg gtaacctatg aggatcctca ggctgtcgga ggacttgctt ctgcactaga     1200

caatcgaaaa cagagttcag aagggatccc cgttgcgcag ccatctgtca tggacgacat     1260

tgaggtgtgg ctcaggaccg acctgaaggg tgatgatctg gaggagggtg tcacaagtga     1320

agagtttgat aaattccttg aagaaagagc caaagctgct gaaatggttc ccgacctccc     1380

ctcgcccccc atggaggctc ctgccccagc ctcaaaccct tctggccgga agaagccaga     1440

gcggtcagag gatgccctct tcgccctgtg agcagctctg tggtttgcct ccccagatgg     1500

cgggtccccg ctcgcacccc gtggacaccg ggcactggcc actcctacat ccccagctcc     1560

acacggcctg cacacctgtg tttccatgga aatgccaccg tgtctgctcc caggcctccc     1620

actagtcagg accagcttca gccacttctt ttctctgagt ggtgggacaa ctgcagccag     1680

agactctctc ccctcccacc atgggcccct ctgcccatgt ttcctcccag gaagagcggg     1740

cagagtggcc cagccccagg cagtgcttcc tgagcagacc acccggactg tctttcctcc     1800

acccgcccat ggagaaagag cacgcccggc cccgccctgt gctcacctct gcctggctca     1860

gcgaccttct caggcattct gccctcctgg gcccctctct ccctgaaggg gctttgtggc     1920

atctctggaa gagcagggtg tgctgcactc atgggcctgg tctcactcct tggacttgtc     1980

accttgtgac atttggctta tcagcatttg agaaggctct gctgggtctc catggtgggg     2040

gtctctcacc ttcttgaccc tctctccatc attcagctgc cagcccaggc ttcacaccca     2100

agctggctca gcagccgagc ctggcaccga gggtccctgc aggctccctg ggcagggaga     2160

gggccaagga caattgggag ggcagcaggc agcccgcaga tggtggccat gtggcacgct     2220

gctgagacga cactaccaat aaaccaaact gccacgcaca cactgcaggc tcacacccgc     2280

aaaaaaaaaa aaaaaa                                                     2296


<210>  101
<211>  2714
<212>  DNA
<213>  Homo sapiens

<400>  101
cccacgcgtc cgcagagctt gagggggggt tgacggcttc tggcgggtgg cggtgttgaa       60

ggcgagagct tgcttggccc gtgtcgcttc tgtcccaaga accggacgga gagtgagggc      120

acgagggtcg ctgtcggggg ctgtcgtctt ccacgtacac gtcgtcgtga ggagcgcagt      180

ccggactctt cccgcaaccc ctccggctcc ctttccgcac gcctcgaggc ggcggcggcc      240

accgagacag cagcgcacct tcccccatcc cttcccctta tcccccagcc caaaagggcc      300

cggtctgcgc cccacccccg cccgtccgcc cgctacgccg ccgccatgtc ggcgcaggcc      360

cagatgcgcg cgatgctgga ccagttgatg ggcacctccc gggacggaga tacaactcgt      420

caacgaatca aattcagtga tgacagagta tgcaagagtc accttctcaa ctgttgtcct      480

catgatgtcc tttctggaac tagaatggat cttggagaat gtctgaaagt ccatgacctg      540

gctttaagag cggattatga aattgcatcc aaagaacaag attttttctt tgaacttgat      600

gccatggatc atctgcagtc attcattgca gattgtgatc gtagaacaga agtggccaag      660

aaaagattag cagaaactca agaagagatt agtgctgaag tagcagcaaa ggcagaacgt      720

gttcatgagt taaatgaaga aattggtaaa ttgttagcca aggtggaaca actaggagct      780

gaagggaatg tggaggaatc ccagaaagta atggatgaag tagagaaagc acgggcaaag      840

aaaagagaag cagaggaagt ttatcggaat tctatgccag cttccagttt tcagcagcag      900

aaacttcgag tctgtgaagt ctgctctgcc tatttaggac ttcatgataa tgacagacga      960

ctggctgatc attttggggg taaactgcac ctgggattta ttgaaataag agagaagctt     1020

gaagaattaa agagagtcgt agctgagaag caggagaaaa gaaaccagga acggctgaaa     1080

cgaagagaag agagagagag agaagaaagg gagaagctga ggaggtcccg atcacacagc     1140

aagaatccaa aaagatccag gtccagagag catcgcagac atcgatctcg ctccatgtca     1200

cgtgaacgca agaggagaac tcgatccaaa tctcgggaga aacgccatcg ccacaggtcc     1260

cgctccagca gccgtagccg cagccgtagc caccagagaa gtcggcacag ttctagagat     1320

aggagcagag aacgatccaa gaggagatcc tcaaaagaaa gattcagaga ccaagactta     1380

gcatcatgtg acagagacag gagttcaaga gacagatcac ctcgtgacag agatcggaaa     1440

gataagaagc ggtcctatga gagtgctaat ggcagatcag aagacaggag gagctctgaa     1500

gagcgcgaag caggggagat ctaactagct gtgtacattt cttcagtcct taagcttcct     1560

acggagttac gtactattgt ttagttcaca gctgttcagg gtgacagtga gcagatccag     1620

acaccagatc cagctaggct agatgtacag tatctaactt gatctgaact gaacctgttt     1680

tccttgatga tgcctaaaac tacatccata gtttctggtg aacctgtaat acagttctga     1740

aagtacagtt ttatataata agatgctgat ctctttattc tttcaagtaa gagtgctagt     1800

gaacaaattg tgttacttgc cttgggattt tttgaacgtt tgtaaaatgc tgtcttccta     1860

gtccaaacag ctgcagcttt gggcattttt ctttttaatt attcttcctc tgactttgta     1920

tcccttaata cctacactct ccaattgtaa gagaaagggg gcagggaagc aatatagctt     1980

ccattctaag gctgtattcc cgttatgaat tactagctga ttacagttca gagcattgat     2040

cctggaatgt gtgctggaga aatttaaaat actggggttt tttgtttaat ggtgcctatt     2100

tagagttgga agttgaacag ctgttgcatt acatactttt gcttttttat tgaaattttg     2160

aaatcaaacg tcttgatttt tctgttctgt tgaattgcta tgttcaggat gttctagggg     2220

gtgggggcag ggactctttt cgtaataagc acttgtttta ttttgtgtgt gtggagtata     2280

aaggctacac ccttattgta aaaaaataat aataataaaa tgaaagaaac aatcaccacc     2340

accattatta aactgtaact tgtctagtaa attgtcacta gaactatttg ctgtgggcat     2400

ttcctctatt ctgttacgtc attaacagtg ccttactgtg caaggcacca aaggacataa     2460

atacgtactt gcaaagattc cagatgagct gttcatgtgg gccccttgct gactatattc     2520

cagccacttc agggttgttt gtaatgaccg ttatagagaa gggctcgacc tgcagaagaa     2580

actggggtgt ttttattctc attcaacaaa cccaaataaa aacagtatat gtaaccaaaa     2640

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaccaa     2700

aaaaaaaaaa aaaa                                                       2714


<210>  102
<211>  2467
<212>  DNA
<213>  Homo sapiens

<400>  102
agagccactc aacagcgctg gaacccattc ggtggggcct ggggcccctc atcccaagcc       60

aggagggttt ctggggaggg gtgcagcccc tggcagactg acagtgtggc ctgggggttt      120

gggggtgcca gggaagcagg ggccaacctc ataggaggag acacgagtgc ggttctcttt      180

cccccactgg ggggcctgct gtgtcagcag ccaggcggga ggcctgggcg gcagagccag      240

tggtacaggg gcctgggcag ggcggtgtct ggcagcagcg gcaccatgtc caccatccag      300

tcggagactg actgctacga catcatcgag gtcttgggca aggggacctt cggggaggta      360

gccaagggct ggcggcggag cacgggcgag atggtggcca tcaagatcct caagaatgac      420

gcctaccgca accgcatcat caaaaacgag ctgaagctgc tgcactgcat gcgaggccta      480

gaccctgaag aggcccacgt catccgcttc cttgagttct tccatgacgc cctcaagttc      540

tacctggtct ttgagctgct ggagcaaaac cttttcgagt tccagaagga gaacaacttc      600

gcgcccctcc ccgcccgcca catccgtaca gtcaccctgc aggtgctcac agccctggcc      660

cggctcaagg agctggctat catccacgct gatctcaagc ctgagaacat catgctggtg      720

gaccagaccc gctgcccctt cagggtcaag gtgattgact tcggatccgc cagcattttc      780

agcgaggtgc gctacgtgaa ggagccatac atccagtcgc gcttctaccg ggcccctgag      840

atcctgctgg ggctgccctt ctgcgagaag gtggacgtgt ggtccctggg ctgcgtcatg      900

gctgagctgc acctgggctg gcctctctac cccggcaaca acgagtacga ccaggtgcgc      960

tacatctgcg aaacccaggg cctgcccaag ccacacctgt tgcacgccgc ctgcaaggcc     1020

caccacttct tcaagcgcaa cccccaccct gacgctgcca acccctggca gctcaagtcc     1080

tcggctgact acctggccga gacgaaggtg cgcccattgg agcgccgcaa gtatatgctc     1140

aagtcgttgg accagattga gacagtgaat ggtggcagtg tggccagtcg gctaaccttc     1200

cctgaccggg aggcgctggc ggagcacgcc gacctcaaga gcatggtgga gctgatcaag     1260

cgcatgctga cctgggagtc acacgaacgc atcagcccca gtgctgccct gcgccacccc     1320

ttcgtgtcca tgcagcagct gcgcagtgcc cacgagacca cccactacta ccagctctcg     1380

ctgcgcagct accgcctctc gctgcaagtg gaggggaagc cccccacgcc cgtcgtggcc     1440

gcagaagatg ggacccccta ctactgtctg gctgaggaga aggaggctgc gggtatgggc     1500

agtgtggccg gcagcagccc cttcttccga gaggagaagg caccaggtat gcaaagagcc     1560

atcgaccagc tggatgacct gagtctgcag gaggctgggc atgggctgtg gggtgagacc     1620

tgcaccaatg cggtctccga catgatggtc cccctcaagg cagccatcac tggccaccat     1680

gtgcccgact cgggccctga gcccatcctg gccttctaca gcagccgcct ggcaggccgc     1740

cacaaggccc gcaagccacc tgcgggttcc aagtccgact ccaacttcag caacctcatt     1800

cggctgagcc aggtctcgcc tgaggatgac aggccctgcc ggggcagcag ctgggaggaa     1860

ggagagcatc tcggggcctc tgctgagcca ctggccatcc tgcagcgaga tgaggatggg     1920

cccaacattg acaacatgac catggaagct gagaggccag accctgagct cttcgacccc     1980

agcagctgtc ctggagaatg gctgagtgag ccagactgca ccctggagag cgtcaggggc     2040

ccacgggctc aggggctccc accccgccgc tcccaccagc atggtccacc ccggggggcc     2100

accagcttcc tccagcatgt caccgggcac cactgatggt gattccaccc ctgcccatca     2160

ctgggggctg cgctagctgg gctggcattc cctcccaacc tgaactgctc ctcagagcca     2220

tctcctgaac ccacaaatta ttcttacaga aagatagtta tccagaaatt ctcattcccc     2280

gtctgcggtg cggtgcgtgc ctgcacacct ctcctaaaca cagcagggct ttggagtctg     2340

gcccatgctc cttggccaga aggacagcag gaaagggggc tgcaccccgc tggccctgcg     2400

ctcgcccttg gccctgctgc ctctgtctat ttcaatatag aactgttcag caaaaaaaaa     2460

aaaaaaa                                                               2467


<210>  103
<211>  3036
<212>  DNA
<213>  Homo sapiens

<400>  103
gctgggagca aagcgctgag ggagctcggt acgccgccgc ctcgcacccg cagcctcgcg       60

cccgccgccg cccgtcccca gagaaccatg gagtctggca gtaccgccgc cagtgaggag      120

gcacgcagcc ttcgagaatg tgagctctac gtccagaagc ataacattca agcgctgctc      180

aaagattcta ttgtgcagtt gtgcactgct cgacctgaga gacccatggc attcctcagg      240

gaatactttg agaggttgga gaaggaggag gcaaaacaga ttcagaatct gcagaaagca      300

ggcactcgta cagactcaag ggaggatgag atttctcctc ctccacccaa cccagtggtt      360

aaaggtagga ggcgacgagg tgctatcagc gctgaggtct acacggagga agatgcggca      420

tcctatgtta gaaaggttat accaaaagat tacaagacaa tggccgcttt agccaaagcc      480

attgaaaaga atgtgctgtt ttcacatctt gatgataatg agagaagtga tatttttgat      540

gccatgtttt cggtctcctt tatcgcagga gagactgtga ttcagcaagg tgatgaaggg      600

gataacttct atgtgattga tcaaggagag acggatgtct atgttaacaa tgaatgggca      660

accagtgttg gggaaggagg gagctttgga gaacttgctt tgatttatgg aacaccgaga      720

gcagccactg tcaaagcaaa gacaaatgtg aaattgtggg gcatcgaccg agacagctat      780

agaagaatcc tcatgggaag cacactgaga aagcggaaga tgtatgagga attccttagt      840

aaagtctcta ttttagagtc tctggacaag tgggaacgtc ttacggtagc tgatgcattg      900

gaaccagtgc agtttgaaga tgggcagaag attgtggtgc agggagaacc aggggatgag      960

ttcttcatta ttttagaggg gtcagctgct gtgctacaac gtcggtcaga aaatgaagag     1020

tttgttgaag tgggaagatt ggggccttct gattattttg gtgaaattgc actactgatg     1080

aatcgtcctc gtgctgccac agttgttgct cgtggcccct tgaagtgcgt taagctggac     1140

cgacctagat ttgaacgtgt tcttggccca tgctcagaca tcctcaaacg aaacatccag     1200

cagtacaaca gttttgtgtc actgtctgtc tgaaatctgc ctcctgtgcc tcccttttct     1260

cctctcccca atccatgctt cactcatgca aactgcttta ttttccctac ttgcagcgcc     1320

aagtggccac tggcatcgca gcttcctgtc tgtttatata ttgaaagttg cttttattgc     1380

accattttca atttggagca ttaactaaat gctcatacac agttaaataa atagaaagag     1440

ttctatggag actttgctgt tactgcttct ctttgtgcag tgttagtatt caccctgggc     1500

agtgagtgcc atgctttttg gtgagggcag atccagcacc tattgaatta ccatagagta     1560

atgatgtaac agtgcaagat tttttttttt aagtgacata attgtccagt tataagcgta     1620

tttagactgt ggccatatat gctgtatttc tttgtagaat aaatggtttc tcattaaact     1680

ctaaagatta gggaaatgga tatagaaaat cttagtatag tagaaagaca tctgcctgta     1740

attaaactag tttaagggtg gaaaaatgaa aatttttgct aattatcaat gggatatgat     1800

tggttcagtt ttttttttcc agagttgttg tttgccaagc taatctgcct ggtttattta     1860

tatcttgtta ttaatgtttc ttctccaatt ctgaaatact tttgagtatg gctatctata     1920

cctgcctttt aagtttgaaa ctaactcata gatgcaaata ttggttagta tttaactaca     1980

tctgcctcgg ctcacaaatt ccgattagac ctttatccag ctagtgccaa ataattgatc     2040

agatgctgaa ttgagaataa gaatttgagg tctacattct tggttgttaa tttagagcgt     2100

ttggttaaag tatgtccttc agctgactcc agtataatct cctctgctca ttaaactgat     2160

tccaggagat tggatttgct gtgactagat acagatggag caaatgtcct aacagagaaa     2220

tagaggtgat gctgctaaag ggagaaatgc caggcggaca aagttcagtg tcgggaattt     2280

tccccgtgac attcactggg gcatgagatt ttggaagaag ttttttactt tggtttagtc     2340

tttttttcct cctttttatt cagctagaat ttctggtggg ttgatggtag ggtataatgt     2400

gtctgtgttg cttcaaattg gtctgaaagg ctatcctgct gaaagtcctg ctttcctatc     2460

tagcatttat tcctctggca aacttttctt tcttttcttt tttaaagtaa acttgtgtat     2520

tgagtcttaa ctgtatttca gtattttcca gccttatgtg ttacattatt ccaatgatac     2580

ccaacagttt atttttatta tttttttaaa caaaatttca cagttctgta atgtaggcac     2640

ttttattttc attgtgattt atatataagg taatgtaggg ttatatttgg gagtgactgc     2700

aagcattttt ccatctgtgt gcaactaact gactctgtta ttgatccctt ctcctgccct     2760

ttcccaggta atttaaattg gtcatggtag atttttttca tagatttgaa aaacttttag     2820

gttgttacca agtatgaagt ataaatctgg ggaagaggtt ttatttacat tttagggtgg     2880

gtaagaaagc caccttgtta caaatttttt aatttccaaa ataatctata ttaaatgagg     2940

gtttctgatc tgtactttgt gtttagctac ctttttatat ttaaaaaatt aaaaatgaaa     3000

attatgttct tacaagctta aagcttgatt tgatct                               3036


<210>  104
<211>  2245
<212>  DNA
<213>  Homo sapiens

<400>  104
gagtggggga cctggaggga ggtggtgaaa tagaatggtc ctgggggacg ggactccagg       60

ggtttgacaa ttaggcgtca agactgactt agacctggga agaaaaccag aggcagtcga      120

gcagagaggc caaacgccag gcagggcgaa gtcagccgga gatggagtgg aaactggagc      180

gcaccgcgcc tcggagggtc cgcacggaag aggagatgct gtgggtactc gattcagtta      240

atgctacgta ttctgacttt aagagcaact ttgcgaagag gctgtccgca gaggttcctg      300

ttgcgagtag ccccattacc acaaggtggc agcaaagtca aactagggct ctgtcctctg      360

attcctttgg ggaagagcag tcaaccacct acctcccaga agcttccgga tcagtgctga      420

agacaccgcc tgagaaagag accttgactc taggatcctg caaagaacaa ctgaagaccc      480

ccagcaaagg aatttctgaa acaagtaact ctgctctcca tttttgcaag gcacctcatg      540

caatggacag agactggaaa gaaagtgttg cctcaaaagg gcagaaatgc ctaaaacaac      600

tctttgtaac ccagaacgtg gttcagcagg ctaatggaaa aatgcagctc tgtgagcaat      660

ccgaatgtgt ttggaaagat cactttagtg gcagcatgaa gaaacgattt gaacaggagg      720

atgttggtgg caaagactaa ttgagaggct ctctgaatac tctatgcaag gctctgttgt      780

tgattctttt aagggaactt aaactatgaa acagatccca cataagccaa gtaattgctc      840

atcagtggat cacggggaca aatgttatcc aaatgctgtg tatataaagc aattctttat      900

gccttgtcca tatctaatga ctctgaaacc ttacagcagg cagcccctgt aaactttcag      960

gtgtacctct ttgcccaaag ctggtaggaa actttggatg gtggtgttgt gagcgttatc     1020

agggaagctc tgtagccatg cagtggggag ataattgcct gtggcagttt ctagaaggtc     1080

ctgttccatg ctacatttgg agctctcagt gctttctttc tttttttttt ttttttttga     1140

gacagagtct cgctctgttg cccaagctgg agtgcagtgg cgcgatctca gttcactgca     1200

acctctgtct cccgggttca agcgattctc ctgtctcagc ttgggattac aggcacacac     1260

caccatgccc agctaatttt tgtattttta gtagagaagg ggtttcacca tgttggccag     1320

actggtctcc aactcctgac ctcagatgct ccacccgcct cagccttcca aaatactgag     1380

attataggca tgagccactg tgcttggcct cccaaagtct tttgaccctg agccccatgt     1440

gttttcattc ctactttctg ttgccatcat ggacgttttt gtgttattca tgagattatt     1500

gtcatggctg gaaaataatt gtttgggagc cagaattctg tgtgagaatc ctcttgagag     1560

aactagcgtg gttcatttca taaatgccaa ggaaacttgc ctgctacatt tcccctctgg     1620

aataagttct ggtaagcata tccatggggt gctttggcaa ggtctcaaaa ataaatgtga     1680

acaaggagac agaaatcctc aatgctaaag tagacttcta tttttatggc ttgtcctaat     1740

tttttttttt ttttttgaga tgaagtcttg ctctgtcgtc caggctggag tgcagtggtg     1800

tgatcttggc tcatggcaac ctccgcctcc cgggagagtt gcttgaacca gggaggcgga     1860

agttgcagtg agctgagacc gtgccactgc tctctagctt ggctgacaga gtgagactct     1920

gtctcaaaaa aaaaaaaaat attttttttg gaaattttct tttaaaaatt atgtagataa     1980

cacatagata cacactttta acttctaaat acagaggtgt ccaatctttt ggcttccctg     2040

ggccacattg gaagaaggat tgttttgggc cacatataga atacactaat actaaagata     2100

gctgatgagc taaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa     2160

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa     2220

aaaaaaaaaa aaaaaaaaaa aaaaa                                           2245


<210>  105
<211>  1188
<212>  DNA
<213>  Homo sapiens

<400>  105
ggagtgtgtc tgaggaaaca catcccggac accacttagg gttagtcttt ctgagctctt       60

cacatctctg actaattatc atcattacca tggagcccaa cagtcccaaa aagatacagt      120

ttgccgtgcc tgtattccag agtcagattg cacctgaagc agcagagcag atcaggaaaa      180

gaagacctac accagcatca cttgtgattc tcaatgagca taacccccca gaaatagatg      240

acaagagggg gcccaacaca caaggggaat tacagaatgc atcccctaag caaaggaagc      300

agagtgtgta cacaccaccc accataaaag gggttaagca tctgaaaggc cagaatgaat      360

cagcattccc tgaagaagaa gaaggcacca atgaaagaga ggagcagcgg gaccattaat      420

tactggtctg cagcaagaag gcttcttgga aataactgaa ctattaactt ttctgagtat      480

accatggaat tccactgctt gacttccaga agcatcctcc atctctgcac cccacactca      540

tacagtagct atgcacatcc tggaagtctc cttgactgaa ctttagaact aagtgcaaaa      600

tgagttgata acaaccagaa gttgacttgt tagtgctgtg cttctactcg agcttggaaa      660

aatcccaaca caaaacaaac accacctccg attccatcat gatgccacgt tgctttctac      720

tggattacct cctgaagcac tttagatatt ttatacataa gtattgacat gtttttcaga      780

agctgtttct tcacttattg cttttttcta ataattttta ttacaccatt tgccaagtcc      840

ttccctttgg ttttagttta ttcctctcta caactaaaaa agggatcttg agtttaggta      900

cattttaagt gattcatttt tagtttttct aattctggaa tctgagcctt ctcttacaac      960

agggagtctt tcaaaaacat ttttttgttt ctttttcaaa ttccactgtg tttatttatt     1020

gccttgtttc tttttcaaat tccattggtc ttgatttaat ttagttccac agattttact     1080

gatagtctac tacctgccaa ctactgaatt atgcagcaga cttataaaaa taaaaaggct     1140

attttattgt tattgcctaa aaaaaaaaaa aaaaaaaaaa aaaaaaaa                  1188


<210>  106
<211>  1783
<212>  DNA
<213>  Homo sapiens

<400>  106
tgttggggaa cacccggcga ttctggcggc tgcttcctgg tggcgcaggg agcccgcgtg       60

tttgcgagtg cgtgtgtgtg cgaagttctc cggctcgact ccgcgctctc ctcgccggcc      120

gccgccgccc agcctgcgcc cgccgtcccc ccagtgcctg ggcacctgtt ggaggcagag      180

ccaggggtgc tgcatgaggg gccgcagggg cgatcgcatg accatcaaca tccaggagca      240

catggccatc aacgtgtgcc ccgggcccat ccggcccatc cgccagatct ctgactactt      300

cccccgggga ccaggacctg aagggggcgg cgggggcggc ggggaggccc ccgcccatct      360

ggtccccctg gctctggccc cccctgcagc cctccttggg gccaccacgc ctgaggatgg      420

tgcggaggtg gacagctatg actcggatga tgccaccgcc ctaggcacgc tggagtttga      480

ccttctctac gaccgggcct cctgcactct gcactgtagc atcctcaggg ccaagggcct      540

caagcccatg gatttcaatg gcctcgccga cccctacgtc aagctgcact tgctgcctgg      600

agcctgtaag gccaataagc taaaaacgaa gactcagagg aacacactga atcccgtgtg      660

gaatgaggac ctgacttaca gcgggatcac agatgacgac atcacgcaca aggtgctcag      720

gatcgccgtc tgtgatgagg acaagctgag tcacaatgag tttattgggg agatccgcgt      780

gcccctccgc cgcctcaagc cttcgcagaa gaagcatttt aacatctgcc tcgagcgcca      840

ggtcccgctg gcgtccccct cttccatgtc agcggcgctg aggggcatct cctgttatct      900

gaaggagttg gagcaggcgg agcaggggca ggggctgctg gaggagcgtg gccgcatcct      960

gctgagtctc agctacagct cgcggcgccg gggactgctg gtaggcatct tgcgctgcgc     1020

ccatctggct gccatggacg tcaacggtta ctcggacccc tacgtcaaga cgtacctgag     1080

gcccgatgtg gacaagaaat ccaagcataa gacgtgtgtg aagaagaaga ctctcaaccc     1140

agaatttaac gaggagtttt tctacgagat agagctctcc actctggcca ccaagaccct     1200

ggaagtcacc gtctgggact atgacattgg caaatccaat gacttcattg gtggcgtgtc     1260

cctggggcca ggtgcccgag gcgaggctcg gaagcactgg agtgactgcc tgcagcagcc     1320

ggacgcagcc ctggagcgct ggcacaccct gaccagtgag ctgccccctg cggccggggc     1380

tctgtcctca gcctgagtgg acagcagtgt cccggcacag gcccatcgag ccgggtccag     1440

tacccaacct tcgcacgagt gtgttgcacg tttacacagg gtgggctgcc cccaccctgc     1500

actacctatt tttgtgagtc tccgtgaccc gggtctgtct gctcatgagg ggctgcggag     1560

ttctatattc acatatgcaa acctcctgcc tgactcgcta gtccctgcaa atatgcaaac     1620

cccccatcat ctgcacaccc gggcagtgct cagagcccgg ccccaggccc ccgcgctcct     1680

cactcctgcc tctccacgct gccccgtccc tctcccccaa cagggaggag gtcggattag     1740

gggaggttca gaggaggaga atgtcccaaa aaaaaaaaaa aaa                       1783


<210>  107
<211>  1717
<212>  DNA
<213>  Homo sapiens

<400>  107
ggccggggaa aaacccggat gagctgggca gcagtgttgg cagtcgcggc tgcgagattt       60

gggcactttt gggggtgccg gtggcccggg ccgatggcgc aaggttgggc aggcttctct      120

gaggaggaac tgaggagact aaagcagact aaagatccat ttgaaccaca gcgacgtctc      180

cccgcgaaga aaagtcgaca acaacttcag cgagaaaaag cccttgtaga gcaaagccaa      240

aaacttgggc ttcaagatgg atcaacctca ttacttccag agcagctgct ttcagcacca      300

aaacagagag ttaacgttca aaaaccacct ttttcttccc ctactcttcc gagtcatttc      360

actctcacct cccccgttgg tgatggacaa ccacagggca ttgaaagtca gccaaaggaa      420

ctgggacttg agaattccca tgatggtcac aacaatgttg agattctacc tccaaagcca      480

gattgcaaat tggagaaaaa gaaagtggaa ttgcaagaaa aatctcgttg ggaagtcctc      540

caacaagaac aacggctaat ggaagagaaa aataaacgta aaaaagctct tttggctaaa      600

gctattgcag aaagatctaa aagaactcag gcagagacca tgaaactaaa gcggatccag      660

aaggagttgc aggctttaga tgacatggtg tcagctgaca ttggaattct caggaaccgg      720

attgatcagg ccagcttaga ctattcatac gctcggtgag ttggggaaat tgaatctgaa      780

caaggagtat gatttaatta atgtttattg ccagctgttc caggggcttt tatgtatatc      840

atcattgaag cctcaaaaca accccattca gtgctgtatt tattcttctt ttgtgctaat      900

tcaagtgtct cctcttcagt gaagtcttcc ttaactctgc cctactagtt aaccttgttc      960

gtgtgccatt agagcagttc ttgcattatt tatttacgtt ttagtctttg ctgcgaaacc     1020

ctcagctatt taatgtttgg aagtgttttt gctcatcttt cagcatctag caaagtaaat     1080

atctgagtgg tttcgccaaa actgttactc tgacaccaag tctgtgttct ttccattaaa     1140

atttttgata tctgatatag tcctatagga ttgaagtcta gtcctcactt tagctttcat     1200

cagagtaaga ggatctagtt tagtttttaa aagcttatga atattttaag catatcctct     1260

gtcttggaaa tttgaaatat tttctctttt tttttccttt caattatact ctgtatgaaa     1320

tggtttaata tatgtttcct tggtttcaac cattggcatt ttttaaaaga gaaaaaatac     1380

catggagtat ttttaaaatg aactaacaca tgtaatgaat tacatggact ttgcagacag     1440

ataaaagggc aaaaaaatat gtccaatttc agggttttca gccctttcaa cattgcttta     1500

atcatcctgg tttgtctttt ttcacaaggg aatgctgtgt taatgactca gttttctatc     1560

ttactctgtt acactagaaa tgaatcagaa tgcctcatta ggccagggta aaccacaaca     1620

tcagaatgtt tatataacaa tttattaaag cggaaatgct tgattgtggt ttttaataaa     1680

ctgttgagtg tttaagaaaa aaaaaaaaaa aaaaaaa                              1717


<210>  108
<211>  1044
<212>  DNA
<213>  Homo sapiens

<400>  108
atgctgggct cagtgaagat ggaggcccat gacctggccg agtggagcta ctacccggag       60

gcgggcgagg tctactcgcc ggtgacccca gtgcccacca tggcccccct caactcctac      120

atgaccctga atcctctaag ctctccctat cctggggggc tccctgcctc cccactgccc      180

tcaggacccc tggcaccccc agcacctgca gcccccctgg ggcccacttt cccaggcctg      240

ggtctgagcg gtggcagcag cagctccggg tacggggccc cgggtcctgg gctggtgcac      300

gggaaggaga tgccgaaggg gtatcgcgcc cctgcacacg ccaagccacc gtattcctat      360

atctcactca tcaccatggc tatccagcag gcgccgggca aggtgctgac cttgagtgaa      420

atctaccagt ggatcatgga cctcttccct tactaccggg acaatcagca gcgctggcag      480

aactccattc gccactcgct gtctttcaac gactgcttcg tcaaggtggc gcgttcccca      540

gacaagcctg gcaagggctc ctactgggcc ctacacccca gctcagggaa catgtttgag      600

aatggctgct acctgcgccg ccagaaacgc ttcaagctgg aggagaaggt gaaaaaaggg      660

ggcagcgggg catcgaccac caggaacggg acagggtctg ctgcctcgac caccaccccc      720

gccgccacag tcacctcccc gccccagccc ccgcctccag cccctgagcc tgaggcccag      780

ggcggggaag atgtgggggc tctggactgt ggctcacccg cttcctccac accctatttc      840

actggcctgg agctcccagg ggacctgaag ctggacgcgc cctacaactt caaccaccct      900

ttctccatca acaacctaat gtcagaacag acaccagcac ctcccaaact ggacgtgggg      960

tttgggggct acggggctga aggtggggag cctggagtct actaccaggg cctctattcc     1020

cgctctttgc ttaatgcatc ctag                                            1044


<210>  109
<211>  1479
<212>  DNA
<213>  Homo sapiens

<400>  109
gaggcgcagc gacggcccgt tccacctcgc gatctgccgg gtacccgggc ggcgtggcgc       60

tcggcctcca gggatccact gtgcggtgcc aaaaaagagg cggaggctcg cggcacagct      120

ctcccggcgc agctctcggg ccgccgccgc cgccgctccc aggcccgtct cccggcccgt      180

ggcagtcggg gctcgcggag aaaacaagtt gagcgcgagc gcgttgattg gttggcggac      240

ggtgcgaggt ggacgctgat tggctgaggg cagcgcgagg cgggcgctga ttggctgcga      300

cgcgccgacg ccggtgtttt gcagtcctgg gcagctcggc agtccagccc ggcccgggtc      360

atggtggtgg gccgagggct gctcggccgc cgcagcctcg ccgcgctggg agccgcctgc      420

gcccgccgag gcctcggtcc agccctgctg ggagttttct gccacacaga tttgcggaag      480

aacctgaccg tggacgaggg caccatgaag gtagaggtgc tgcctgccct gaccgacaac      540

tacatgtacc tggtcattga tgatgagacc aaggaggctg ccattgtgga tccggtgcag      600

ccccagaagg tcgtggacgc ggcgagaaag cacggggtga aactgaccac agtgctcacc      660

acccaccacc actgggacca tgctggcggg aatgagaaac tggtcaagct ggagtcggga      720

ctgaaggtgt acgggggtga cgaccgtatc ggggccctga ctcacaagat cactcacctg      780

tccacactgc aggtggggtc tctgaacgtc aagtgcctgg cgaccccgtg ccacacttca      840

ggacacattt gttacttcgt gagcaagccc ggaggctcgg agccccctgc cgtgttcaca      900

ggtgacacct tgtttgtggc tggctgcggg aagttctatg aagggactgc ggatgagatg      960

tgtaaagctc tgctggaggt cttgggccgg ctccccccgg acacaagagt ctactgtggc     1020

cacgagtaca ccatcaacaa cctcaagttt gcacgccacg tggagcccgg caatgccgcc     1080

atccgggaga agctggcctg ggccaaggag aagtacagca tcggggagcc cacagtgcca     1140

tccaccctgg cagaggagtt tacctacaac cccttcatga gagtgaggga gaagacggtg     1200

cagcagcacg caggtgagac ggacccggtg accaccatgc gggccgtgcg cagggagaag     1260

gaccagttca agatgccccg ggactgaggc cgccctgcac cttcagcgga tttggggatt     1320

aggctctttt aggtaactgg ctttcctgct ggtccgtgcg ggaaattcag tcttgattta     1380

accttaattt tacagccctt ggcttgtgtt atcggacatt ctaatgcata tttataagag     1440

aagtttaaca agtatttatt cccataaaaa aaaaaaaaa                            1479


<210>  110
<211>  1561
<212>  DNA
<213>  Homo sapiens

<400>  110
cggcaggcgc ccggggtcct cagcgctgca gactcctgac ctgccgactg cggatcccga       60

gtccccggat cccggaccca tcctgtggag cccactcctg gcagacgccg cgatgcccgg      120

cccttggttg ctgctcgctc tggctttgac cctgaacctg accggtgtcc ccggcggccg      180

tgctcagcca gaggcggccc agcaggaggc agtgacggcc gcggagcatc cgggcctgga      240

tgacttcctg cgccaggtgg agcgcctcct cttcctccgg gaaaacatcc agcggctgca      300

aggggaccag ggtgagcact ccgcgtccca gatctttcaa tctgactggc tctccaaacg      360

tcagcatcca ggcaaaagag aggaggagga ggaagaggga gttgaagaag aggaagagga      420

agaagggggg gctgtgggac cccacaaacg gcagcaccct ggccgacgag aagatgaggc      480

ttcatggtca gtcgatgtaa cccagcacaa gcggcagcat cctggccggc gctccccctg      540

gcttgcatat gctgtcccga agcggcagca cccaggcaga aggctggcag atcccaaggc      600

tcaaaggagc tgggaagaag aggaggagga ggaagagaga gaggaagacc tgatgcctga      660

aaaacgccag catccgggca agagggccct gggaggcccc tgtgggcccc agggagccta      720

tggtcaagcg ggcctcctgc tggggctcct ggatgacctg agtaggagcc agggagctga      780

ggaaaagcgg cagcaccctg gtcggcgggc agcctgggtc agggagcccc tggaggagtg      840

aacccagttt tccctgaagt cgagtttgtg gtctaaggat gtcttgagcc ctgtgtgccc      900

caccattcat gacctctgta ttctctagtt agatccctga ccataagcct gagcccctcc      960

ctcccagccc catattcaca cacatcccag cccctggcct tgccctcttc ctttaggcat     1020

gtgagaaaat cagcctagca gtttaaaccc cactttcctc cacttagcac cataggcaag     1080

ggggcagatc ccagagcccc tctcaccccc cccaccacag gcctgctcct tccttagcct     1140

tggctaagat ggtccttctg tgtcttgcaa agactcccca agtggacagg gagcccctgg     1200

gagggcagcc agtgagggtg gggtgggact gaagcgttgt gtgcaaatcc agcttccatc     1260

ccctccccaa cctggcagga ttctccatgt gtaaacttca cccccaggac ccaggatctt     1320

ctcctttctg ggcatccctt tgtgggtggg cagagccctg acccacagct gtgttactgc     1380

ttggagaagc atatgtaggg gcataccctg tggtgttgtg ctgtgtctgg ctgtgggata     1440

aatgtgtgtg ggaatattga aacatcgcct aggaattgtg gtttgtatat aaccctctaa     1500

gcccctatcc cttgtcgatg acagtcatcc taatgataat aaaacctgca tccagataat     1560

c                                                                     1561


<210>  111
<211>  2730
<212>  DNA
<213>  Homo sapiens

<400>  111
aagtttaagt gaatatgcgg cttgggctcc aaaagttgct gtacggtatt ttattttaaa       60

gtagaaatct gtccgctttt cacttacgga ggccttacag tgtgtgttct gtgttacttg      120

agtttatacg cactgcagaa tttgtttatc ctgctctttt ggaaacgtat tccggaagcg      180

aaaccctgag taatcggaag tggttaggag tgagagagct gctggatatg cggagggact      240

gggcgggtcg gcttccgaat ggaagaggtc tgtgagaagt taacctggtg ataccgatcc      300

gaagagccta tcaagtgaag ccccctgaaa tacggagaat aagaatctta gaggttgttc      360

agcagaagtc ttggagtgca ttttcagtgg ttaaggtgaa aaaatgacta ctaaaaattt      420

agaaaccaaa gtcaccgtta cttcatcccc aatccgagga gcaggagatg gaatggaaac      480

tgaggaacca cctaaatctg ttgaagttac ctccggagtc caatctagaa agcatcatag      540

tcttcagagt ccatggaaga aagcagttcc atcagagagc ccaggagttc ttcagctagg      600

gaaaatgctc actgaaaaag caatggaagt taaagctgta agaatattag ttcccaaagc      660

tgctataact catgatatcc ccaacaaaaa tacaaaggtt aagtctctgg gacatcataa      720

aggagaattc cttggtcagt cagagggagt tatagaacct aataaggaac tctcagaggt      780

aaagaatgta ttggaaaagc tcaagaattc tgaaagaagg ttactacagg acaaagaagg      840

tctttcaaac cagctccgtg tacagacaga ggtaaatcgt gagttaaaaa agttactggt      900

ggcttctgtt ggggatgatc ttcagtatca ctttgaacgt ctagcccgtg agaaaaatca      960

gcttatttta gaaaatgaag ccctaggtcg aaacacagct cagctttctg aacagttaga     1020

acgtatgtca atacagtgtg atgtatggcg aagtaaattc cttgcaagca gggtaatggc     1080

agatgagtta accaactcaa gagcagcttt acagcgtcaa aaccgtgatg cacacggggc     1140

tatacaagat ctcctaagtg aacgggaaca gtttcgtcaa gaaatgatag ctacccagaa     1200

attattggag gagctcttag tttccttgca atggggaaga gagcaaactt actcccctag     1260

tgtacaaccc cacagcacag cagagctagc attaacaaat cacaagttgg caaaagcagt     1320

aaattctcat cttctgggaa atgttggcat taacaatcaa aaaaagattc catcaacagt     1380

tgaattctgc agcaccccag ctgagaaaat ggctgaaacg gttctaagaa ttttagatcc     1440

agttacctgc aaagagagtt cacctgataa tccatttttt gagtcttcac caaccacctt     1500

acttgctaca aagaaaaata ttggacgatt tcatccctat actagatatg aaaatataac     1560

tttcaattgc tgcaatcact gccggggaga actgattgcc ctttaacagt caatatgttg     1620

gaggcatgct aaggtacttc cttattaccc aagagtcatt attatttggg agctggggtt     1680

cttacaatgc tagaaataat atcacttcct atttacataa tgtatacacc caaagatatt     1740

ttatgtacta gactccagat taccctttct taataaatat ctcagggtaa ggaaagaaag     1800

aaactgtata gatatattta aaatagagaa tactttccaa gcaatacatg atacttttcc     1860

taaaagactc taaaagaaaa agattctgta actctctttt agcaccaaat tattgtttat     1920

cttgctggat attttatatg aacagtgtta atttagatgc actaaagcaa aggtaggcaa     1980

actacaacca tgagtcaaac atggccacac ccattcattt gctattgtct aagcctggtt     2040

ttggccacta caactgcaga gttgaataga tgcagcagat cctttacaga aaagttttct     2100

gacctcaatt ctaaagtaat tgtagtaggg aggctggagg actttctttc cctttatggt     2160

aattttttga gctacaaaag aggccttgca gaaatggggt gaagggatta atcttttaaa     2220

aataaatgct atatattagg aaaataaaaa atattttaga gccaagttaa caagtacttc     2280

aggaaaacat gctagtttta tgcagggcat tctgtattcc aaatggatac aatccgacat     2340

atataaaaga aacagattct taactattga ctcttattta gcaaatgcaa cagacaagaa     2400

tatccaactt gatatttata aaaggtagac tttttccaaa agtgtataag ctcaaagaaa     2460

aaatgcaacc tgtcaattaa tatatactat gtaatatata ttattgtgta tttatgatta     2520

gccatcataa atgcccattg cttggccttt aagaataatc acaaaatatt tatattaaat     2580

tatacaaatt tgttgcagaa gtgcctgtga gagaaatctt caaaagacaa acctggtcaa     2640

ataataataa ttttaatgtc aatgattttt tttgtctgac tcatctgagt tatatttagt     2700

tttcaagtgg caataaattt atctaccttc                                      2730


<210>  112
<211>  616
<212>  DNA
<213>  Homo sapiens

<400>  112
ctgaagtgaa aacgagacca aggtctagct ctactgttgg tacttatgag atccagtcct       60

ggcaacatgg agaggattgt catctgtctg atggtcatct tcttggggac actggtccac      120

aaatcaagct cccaaggtca agatcgccac atgattagaa tgcgtcaact tatagatatt      180

gttgatcagc tgaaaaatta tgtgaatgac ttggtccctg aatttctgcc agctccagaa      240

gatgtagaga caaactgtga gtggtcagct ttttcctgct ttcagaaggc ccaactaaag      300

tcagcaaata caggaaacaa tgaaaggata atcaatgtat caattaaaaa gctgaagagg      360

aaaccacctt ccacaaatgc agggagaaga cagaaacaca gactaacatg cccttcatgt      420

gattcttatg agaaaaaacc acccaaagaa ttcctagaaa gattcaaatc acttctccaa      480

aagatgattc atcagcatct gtcctctaga acacacggaa gtgaagattc ctgaggatct      540

aacttgcagt tggacactat gttacatact ctaatatagt agtgaaagtc atttctttgt      600

attccaagtg gaggag                                                      616


<210>  113
<211>  1266
<212>  DNA
<213>  Homo sapiens

<400>  113
cgtgaggagg gaaggagaga tggggggacg tgggacaggg agaaaacaac ataaatcata       60

tatatatagc atgcaaattg gaaggtgatc agcacacaat aggcattcaa taaatgttga      120

aataatgaca ccccactgtc tccttgccct caaatggtct cccctaacgt atcccctgtt      180

gtcttgcttc ttctcttccc acttgcagag cctgctgccc acgtctcttc cctgagctgc      240

ctgctggggt catggagctg ccaacaaagc ctggcacctt cgacctgggc ctggccacat      300

ggagcccttc cttccagggg gaaacccacc gggctcaggc acgccgcagg gatgttggca      360

ggcagctgcc tgagtacaag gctgtggtgg tgggcgccag tggcgtgggc aagagtgcgc      420

tgaccatcca gctgaaccac cagtgcttcg tggaggacca cgaccccacc atccaggatt      480

cctactggaa ggagttgacc ctggacagtg gggactgcat tctgaatgtg ctggacacag      540

cagggcaggc catccatagg gccctgcgtg accagtgcct ggctgtctgt gatggtgtgc      600

tgggcgtctt cgctctcgat gacccctcgt ctctgatcca gctgcagcag atatgggcca      660

cctggggccc tcaccccgcc cagccccttg tcctcgtggg caacaagtgt gaccttgtga      720

ccactgctgg agatgctcat gccgctgctg cagccctcgc acacagctgg ggggcccact      780

tcgtggagac ctcggccaaa acacggcaag gcgtggagga ggccttttcc ctgctggtcc      840

atgagatcca gagggtccag gaggccatgg cgaaggagcc catggcaagg tcctgtaggg      900

agaagacccg gcaccagaag gccacctgcc actgtggctg ctctgtggcc tgaaggtctt      960

ggccaagaaa tgtagacctt tccccaggcc agggtgattg ttcatttgac atgagacccc     1020

tgaggcaact agctttgagg gacacatcag gtatactagg gaaagatgga catctctctt     1080

gttttcactt ggtgaggggc tttttggtaa catgggagtg cctaatgttg cttttgttat     1140

gtcaagttga aagattttgt gcaaaattaa ataaatggtg ttttgggttt caaagctgcc     1200

tccatgccga gtgttgtgtg ggtgggagtg agactgggta gaatgttact tgagttgtga     1260

gaattc                                                                1266


<210>  114
<211>  2793
<212>  DNA
<213>  Homo sapiens

<400>  114
cctgagcagc cgctgggaga cagacggcaa ccaggttgcc cctctttgct ccagctagaa       60

agacttgagt tagacaagca gcagcacacg cctccctacc tcatggcgac agaaaatgga      120

gcagttgagc tgggaattca gaacccatca acagacaagg cacctaaagg tcccacaggt      180

gaaagacccc tggctgcagg gaaagaccct ggccccccag acccaaagaa agctccggat      240

ccacccaccc tgaagaaaga tgccaaagcc cctgcctcag agaaagggga tggtaccctg      300

gcccaaccct caactagcag ccaaggcccc aaaggagagg gtgacagggg cggggggccc      360

gcggagggca gtgctgggcc cccggcagcc ctgccccagc agactgcgac acctgagacc      420

agcgtcaaga agcccaaggc tgagcaggga gcctcaggca gccaggatcc tggaaagccc      480

agggtgggca agaaggcagc agagggccaa gcagcagcca ggaggggctc acctgccttt      540

ctgcatagcc ccagctgtcc tgccatcatc tccagttctg agaagctgct ggccaagaag      600

cccccaagcg aggcatcaga gctcaccttt gaaggggtgc ccatgaccca cagccccacg      660

gatcccaggc cagccaaggc agaagaagga aagaacatcc tggcagagag ccagaaggaa      720

gtgggagaga aaaccccagg ccaggctggc caggctaaga tgcaagggga cacctcgagg      780

gggattgagt tccaggctgt tccctcagag aaatccgagg tggggcaggc cctctgtctc      840

acagccaggg aggaggactg cttccagatt ttggatgatt gcccgccacc tccggccccc      900

ttccctcacc gcatggtgga gctgaggacc gggaatgtca gcagtgaatt cagtatgaac      960

tccaaggagg cgctcggagg tggcaagttt ggggcagtct gtacctgcat ggagaaagcc     1020

acaggcctca agctggcagc caaggtcatc aagaaacaga ctcccaaaga caaggaaatg     1080

gtgttgctgg agattgaggt catgaaccag ctgaaccacc gcaatctgat ccagctgtat     1140

gcagccatcg agactccgca tgagatcgtc ctgttcatgg agtacatcga gggcggagag     1200

ctcttcgaga ggattgtgga tgaggactac catctgaccg aggtggacac catggtgttt     1260

gtcaggcaga tctgtgacgg gatcctcttc atgcacaaga tgagggtttt gcacctggac     1320

ctcaagccag agaacatcct gtgtgtcaac accaccgggc atttggtgaa gatcattgac     1380

tttggcctgg cacggaggta taaccccaac gagaagctga aggtgaactt tgggacccca     1440

gagttcctgt cacctgaggt ggtgaattat gaccaaatct ccgataagac agacatgtgg     1500

agtatggggg tgatcaccta catgctgctg agcggcctct cccccttcct gggagatgat     1560

gacacagaga ccctaaacaa cgttctatct ggcaactggt actttgatga agagaccttt     1620

gaggccgtat cagacgaggc caaagacttt gtctccaacc tcatcgtcaa ggaccagagg     1680

gcccggatga acgctgccca gtgtctcgcc catccctggc tcaacaacct ggcggagaaa     1740

gccaaacgct gtaaccgacg ccttaagtcc cagatcttgc ttaagaaata cctcatgaag     1800

aggcgctgga agaaaaactt cattgctgtc agcgctgcca accgcttcaa gaagatcagc     1860

agctcggggg cactgatggc tctgggggtc tgagccctgg gcgcagctga agcctggacg     1920

cagccacaca gtggccgggg ctgaagccac acagcccaga aggccagaaa aggcagccag     1980

atccccaggg cagcctcgtt aggacaaggc tgtgccaggc tgggaggctc ggggctcccc     2040

acgcccccat gcagtgaccg cttccccgat gtgagccgcc tcggagtgtg gcctggatcc     2100

atcctgctag cacctcccca gacagggctc cagcctgtcg gccacacccc agactccagg     2160

cccccgttga agccgctccc ggttccctcc ccagctcctc gtctttgaac tgccgccgcc     2220

gtggtgaccc ctgctttgcc ccactgggag agtccttagc ctgggcctcc tcctagctgg     2280

agtgccatgg ctggggggtc tcagcatgta gggcttctgt ggttgtggat gggaggctcc     2340

tggtggggca gaaaggctgc aacgctgatt cctaaggccc agctgccagg gaagacagag     2400

caggctttgt gagagaggac ctccatgccc ccgccacctc cccactccag cagataaggc     2460

cgagcccaca ccatctggcc caggctggcc cccacccacc ttccttgcga ccaccaacac     2520

acaggaactc tgtgtgagag agagggcgcc cagcccaggc ctggtggagg gggaggggag     2580

aagccaaggg acacaggaga ccacccccga gcttgcctca gggccaagcc ggcccaaccc     2640

aaccactcgg ggcccccatc ttgggggtca cccatggcct cagatgatgg ggtcagcagg     2700

cccaggagaa ttaggaaggc catggggcag cctccagtct gctctcagct tgtgccttgt     2760

aaataaatgt acaggttgga tgtggcctcc ttc                                  2793


<210>  115
<211>  3430
<212>  DNA
<213>  Homo sapiens

<400>  115
agacgtttcc cgccggcggg agctgtggct gtgattgaga gaggggttag aggcgggtcc       60

cagcgctgcc gcaccatggc ggaccagctt tatctggaaa atatagacga gttcgtcacg      120

gaccaaaaca agatcgtgac atacaaatgg ctgagctata cactaggggt tcatgttaac      180

caggccaaac agatgctgta tgattatgtt gaaaggaaac gaaaagaaaa ttcaggagcc      240

caactgcatg ttacctactt ggtgtctggc agtctcattc agaatggaca ttcctgccac      300

aaggttgcag tagtgagaga agataaattg gaagcagtga agtccaagct agctgtgact      360

gccagcatcc atgtgtacag catccagaaa gccatgctaa aggacagtgg gcctctgttc      420

aatactgact atgacatcct taaaagcaac ttgcagaact gcagcaaatt tagtgctata      480

caatgtgcag ctgccgtccc tagagctcct gctgaatcct cttcgtcttc caaaaagttt      540

gagcagtcac atcttcacat gtcaagtgag acacaagcca acaatgagct gaccaccaat      600

ggtcatggcc cacctgcatc caagcaggtt tcccagcagc ccaaaggaat tatgggaatg      660

tttgcctcca aagctgctgc taaaacccaa gaaaccaaca aggaaacgaa aacagaggct      720

aaagaagtaa caaatgcatc tgcagcaggc aacaaggcac cagggaaagg gaatatgatg      780

agcaactttt ttggaaaagc tgctatgaat aaatttaaag tcaatttgga ctcagaacaa      840

gcagtgaaag aagaaaaaat agtggagcag cctacagtgt ctgtcacgga accaaagctg      900

gcaactcctg caggcctgaa aaaatccagc aaaaaagcag agcctgttaa ggtgctgcag      960

aaggaaaaaa aaagggggaa gcgagtagca ttatctgatg atgagacaaa ggaaactgaa     1020

aacatgagga aaaagaggag aagaatcaaa cttcctgaat ctgatagcag tgaagatgaa     1080

gtctttccag actctcctgg ggcttatgaa gctgagtcac catccccacc tcctcctccg     1140

tctccacctc ttgaaccagt gccaaagact gagcctgaac ctccttctgt caagagctca     1200

agtggagaaa acaaaagaaa acgaaaacgc gtactaaaat ctaaaactta cctggatggg     1260

gaaggctgca tagtgactga aaaagtctac gagagtgaat cctgcacaga tagtgaagag     1320

gagcttaaca tgaagacatc ctcagtacac agaccccctg ccatgactgt gaaaaaagaa     1380

cccagagagg aacgaaaggg ccccaagaaa gggactgctg ctctgggcaa agccaacaga     1440

caggtgtcca ttactggctt cttccagagg aaataaactg ccatctctgg tagatcagag     1500

acttggagtg gtcaagggag aagaccaaga aatgtactcc tcacttacta tgtaagttca     1560

tctagatctc cacctcacct gtatcaaaag actgttcttt catcctgtga ggtttatact     1620

atttctggtt tttaaccaaa aggaaatcat ctggaagcag gaggcaaaaa gctgttacct     1680

tctaatgaca tttaaaaagc acagtctttg acctgtccag gagaaggatt tactccaaaa     1740

ttatactgga acagttttca gaattctcac tgaagccatt tagtggctaa cccactgtgc     1800

tccactcacc ctatgccctg gtccgcatat ggcacaggaa ttattccttc ttgttcctct     1860

gtattctaag aattcatgtg ggtgtttctt atccttacat tctgctggat acgtttaccc     1920

ctcttgtctt cctgcagtac cacacttctg tcccctaacc tcctgaggct gttctctgta     1980

agtcttttaa gttttggttg gactaaaggc tgaagtgaaa atctccctgt aatcctcttc     2040

ctccattatg cagtacacgg acacctggct acagaccagg acgtggcttg tgttctgttc     2100

ctttcacaaa agctctctgg gaccttcact tgcaattagt ggttagggaa aagcctcagg     2160

cagaacacaa atagaaattt aatgatgtgt tcaactccac cagaaattac ctcgagtcag     2220

cattgacgat attggaggag ctgccgtgct gctgatacgg ggtgtgcttt atgctgctct     2280

ttgcggtttg ttgatcccct cctcccccac tctcaatacc tagagagtga aacccgtaca     2340

atgagataaa gactaaaaag agaaatccct tcctatatac agtgtgctac atttacaaaa     2400

aatttctcct taagaaaaca gaatattcaa aaacagcact tttccaggaa gttagtgagg     2460

aagataaggc acacatttat ttataaatgg atgttgctcc tttgtatttt tagcttccct     2520

atttgcttaa aagtacaggc tccctaagag aggatggaga gggagagact gaattgttag     2580

taggtctaaa catcaaagaa aacattttta ttagttactt atggaaaatc atctattaca     2640

atgataacct tcaagtgact tccattatgg ctggacaggc ggtgagctca gtggattgca     2700

gtggtgtgct ggtgattttg cacagtgagc tctgcggaag gggtcaggct caactgctga     2760

tgtgtctcac acgtagcaga caaggggtgt ctgactggct tcttttgcct caagatggtg     2820

tatgtcgtaa gtgatgcaat cagctgtctg ctttttaagg ttgggattgt gctgactttg     2880

ggattaacat gagcttcttt agcaaccaag catgaacttg attaagacca gaagtttggg     2940

agatgagtcc tggcattatg tctaggacta aagcagtggc tttgtatagc aagctgagta     3000

aaggttgaca tattccaaaa cccttctttt taaaatgaaa aaggatggag agaaggatgg     3060

aaagcctgga cttaaacctt tagaaaaaac ttctggagag aaatcccttt taaacagtta     3120

cttttgtcat tgcctctggt catttgtcta aataggaatg gaaaattaaa agaaaagcaa     3180

caatccaatc ttttttctaa aaattatgct ggggtctcga ctaaaactga atttgaattg     3240

gaaaattctg gtgttggttg gagttccatc ttgcaaggga taatacaaat cctatgatct     3300

ctatgcccaa tatgctgcct caactctgag ctgtctgcaa ggcttagtaa gtattgagtg     3360

gtgttttttt tttcttttta tacaatacca tgttaaccac atgagttaaa taaatttgag     3420

aagttgtttt                                                            3430


<210>  116
<211>  3811
<212>  DNA
<213>  Homo sapiens

<400>  116
tgctgcctcc tatagaccca gactctgatt ggcagtggag tccagggcct gagctcaggc       60

ctgggaaaga ctaggccccc tttaggtttc aggccttgaa ggaccatcca gacttaggga      120

gcctgggcct tggggaggga gagaccctga tgccaggact gagctttggg cagcgaggtg      180

gggagggaag gtggccgcat tcagaggtgc cttggactca caacaacacc cccacccccg      240

tgtgtgcagc cgtgttgccg cccgctgtgc tatgagcagt cagagcgccg tctccacaag      300

agtttacaaa tgaaaatgga ggaaatgtct ttgtctggcc tggataacag caaactagag      360

gccatcgctc aggagatata cgcggacctg gtcgaggatt cttgtttggg attctgcttt      420

gaggtacacc gggctgtcaa gtgtggctac ttcttcttgg acgacacgga ccctgatagc      480

atgaaggatt ttgagatcgt ggaccagccg ggcttggaca tctttggaca ggttttcaac      540

cagtggaaga gcaaggagtg tgtttgcccc aattgcagtc gcagcattgc cgcctcccgc      600

tttgctcccc atctggagaa gtgcctggga atgggtcgga acagcagccg aatcgccaac      660

cgccggattg ccaatagcaa caatatgaat aagtctgaga gtgaccaaga agataatgat      720

gacatcaatg acaacgactg gtcctatggc tcggagaaga aagccaagaa gagaaagtca      780

gacaagaacc ccaattcccc tcgaagatcc aagtcattaa aacacaaaaa tggggaactt      840

agcaattcgg atccttttaa gtataacaat tcaactggga tcagctatga gaccctgggg      900

ccggaggagc ttcgcagcct gctaaccacg caatgtgggg tgatttctga acacaccaag      960

aagatgtgca caaggtccct gcgctgccca cagcacacag atgagcagag gcgaaccgta     1020

cggatttatt ttctcgggcc ctcggctgtc cttccagagg tcgagagctc cctggataat     1080

gacagctttg acatgactga cagccaggcc ctgatcagcc ggcttcagtg ggacggctcc     1140

tctgacctct caccctctga ttcaggctcc tccaagacga gtgaaaatca gggatggggt     1200

ctaggtacca acagctctga gtcacggaaa accaagaaaa agaaatccca tctgagcctg     1260

gtagggactg cctccggcct aggttccaac aagaagaaga agccaaagcc accggcaccc     1320

ccgacgccca gcatctatga tgacatcaac tgacttgggt gcaagggata gcctttggct     1380

gagcagagcc ctctctcctg acccccaccc aggtggcata gcctggcaaa tggacggctg     1440

ctgggggttg gggcttggga agcttggtgg gccaggcagg cagaggatcc gattatgcgc     1500

ccctgggggg tgtcaaagtc ctctgcaatg gagcacgact cctcggcgtg caggactcag     1560

acctggacat attatgcctt ggacataagt ttggtgggga ggcggttttc ctatttattc     1620

tgtgagttac tggatgtcca gctaggccag gggcctgacc tgggcactgt gccagggcac     1680

tgcctgcccc ccaccccagg aactggacta agccctgctg aggggcaatg tggcgacccg     1740

ggaggctgtg ggttggaagc tgagcctgga gggggcctgc ctcggccgcc ctcagcaatg     1800

tgaatgggtc cggtgcttgg agctgagggg caaggctggg catgtcctgt ctgtgtgcag     1860

aatcttatca aatgccccca gtcccagggg taggcaggca cagagtgctg tctgctgagg     1920

tgggcgtcca gaactgccgc caccttccct gcccctcaca ggggcagccc tttcccctca     1980

gtccccatgg gcctccttgg cagcaggagc tgtccttttg ttgggtgcca ggaaagggcc     2040

tccagcctct acagcttcaa ggaatgggaa agggagggta ggaagaggga gaagtgtcag     2100

aattcctccc cctgcctctc ctccctgacc cagggctggt gaggagtggg gccccaaggt     2160

gagagggaac ggtgctgctt tatttgaaat gttttcttac ctcattccct gccccaggaa     2220

gggacccagc ctcaccctcc tggggtggcc ccgtgttcct cctgcccacc ctgccccact     2280

gccctaccgg ggcagcccag gttcccaact gctgcttcca cccccttcac cttgactggc     2340

ttcagttcct ctcagcgctc ctgcctccaa agcgtgccct gtttcccttc cttagcgctt     2400

ttaagttatt tattctgtac ttgtggtttg gggctctgag gaaaatccta atcttgtgcc     2460

tctccccctt tgctaggagt tgggtgggaa gagagggtgg cctctgtgcc ccaggttgtc     2520

agtggagggg aaggggtgtc actgcccctc tgtgggactg tcatgccagt gtgcccacct     2580

gcctggtcta catcctaaag agatgtaccg tcccccctcc atgcgggcac caccactccc     2640

aggagccaag ctggaggacc gcgacctggg ctgggagcag agctgactga catgggtgga     2700

ggtgaccctg agccaagttc tctggcactt gctggacatg tcccctaccc tcttcccaag     2760

aggagccatc ccacatttgg gtagttagta cccaggactg gttggactga tcgggttagg     2820

gaccctagag ggttaaggga acaacagaga tggggctgca atgccctgtc tggaactccg     2880

ctctcccgct ggggtggttc tgattgtggc tcatgcctgg ttgcaaattg gtttttaacc     2940

cacaaattgt gattattttt taaaaagcca aacagatttt ggcaggagtt agaataaatc     3000

ccggggcctg ggcttctcta ttcttggccc tccgtagtct ccctccgaga ggaggccaga     3060

gggagaggag gatctcagca ggcctctagc cgcttccaga tgcagtctgg ggagtgggct     3120

gaaggtgaag ggaggaaggc tgtgggccac tctcccttct gagaggcagc tgcagctcag     3180

gccctaatac actctttgcc ctgtggcctc tcccttttcc ccccttctgg ttggaggagg     3240

gagaagtggg aagtagcttg ggaactggtt tgtccacata aacttcccca ttgttccttg     3300

gcccgccctc agggcagagc cccctgccca ggctgggtaa gagatgggct tggtccagca     3360

gggaccctga gggaacaaac ccttttcctt ctggggagag agtgcccccc ctaccatgta     3420

gttgaacagg ggctaggagc tccccactcc cctccctcta acagcaggct gtgtgggttt     3480

caattcccat ccttcccacc ccggctaggt gtcgtccacc ctgtatcctg tgtctgagtg     3540

tgtgtggggg ggttctgtac taatttccat ggccggtggc ttttccttcc atgcatcact     3600

cccccccgca tgcccagggg ccacccgcct ggcattaccg catgctgggg tcattggggg     3660

aggggggtgg ggctcacgct gtcctgtggt cttgagattt ttatttttgc atatgtaatc     3720

cattctgtac aggtagctaa ctttgtaaac gctgtgtatt ccctctgccc ccatggctgc     3780

tggtgtaaat aaactgcatc tcccgttggt a                                    3811


<210>  117
<211>  1259
<212>  DNA
<213>  Homo sapiens

<400>  117
gcgggcgcga ggcggcggcg gaggcccgag cccggcccag cctcgtcccg cccggagccc       60

gcctggctgc taccccgacc ccggctccgg tcccgtcctg tcccggcgcg ccgcggcctc      120

gccccggccc ccgctcggcg cctcccgagg gagcggcgct gccggccgag agcgcaggcc      180

cggccatgac cgacttcaaa ttgggtatcg tgcggctcgg ccgggtggcc gggaagacca      240

aatacacgct gatcgatgag caggacatcc cgctggtgga gagctactcc tttgaggccc      300

gaatggaagt ggatgcagat ggaaatggtg ctaagatatt tgcctatgcc tttgacaaga      360

accgaggaag gggctctggg agactccttc atgagctgct gtgggagcgg caccgggggg      420

gcgtggcccc gggcttccag gtggtgcacc tcaacgctgt gaccgtggac aatcgcctgg      480

acaacctgca actggtgccg tggggctggc ggcccaaggc tgaagagacc tccagcaagc      540

agagggagca aagcttgtat tggcttgcaa ttcagcagct gcctacagac cctatagaag      600

aacagtttcc tgtcctaaat gtgacccggt attataatgc caacggggat gtagtggaag      660

aggaggagaa ctcttgcacc tactatgagt gccactaccc tccctgcaca gtgattgaga      720

agcagctccg ggagttcaac atctgtgggc gctgccaggt ggcccggtac tgcggctccc      780

agtgccagca gaaggactgg cctgcccaca agaagcactg tcgggagagg aagcgtccct      840

tccagcatga gcttgagcca gagcgatgac gggcagggga gccacacata ctcacagccc      900

ccgggctcta ccctgggcac agcagagaca gactggtggt tgaacctgga ggtgccaaaa      960

aagccagctg cgggcccagg acagctgccg tgagactccc gatgtcacag gcagtctgtg     1020

tggttacagc gcccctcagt gttcatctcc agcagagaca acggaggagg ctcccaccag     1080

gacggttctc attatttata tgttaatatg tttgtaaact catgtacagt tttttttggg     1140

ggggaggcaa tgggaagggt agaaattaca aatagaatca tttgcaaaaa aaaaaaaaaa     1200

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaa      1259


<210>  118
<211>  1261
<212>  DNA
<213>  Homo sapiens

<400>  118
catttttcag tcaagtctgt ttgtttgctt cttcagaaat gttttttaca atctcaagaa       60

aaaatatgtc ccagaaattg agtttactgt tgcttgtatt tggactcatt tggggattga      120

tgttactgca ctatactttt caacaaccaa gacatcaaag cagtgtcaag ttacgtgagc      180

aaatactaga cttaagcaaa agatatgtta aagctctagc agaggaaaat aagaacacag      240

tggatgtcga gaacggtgct tctatggcag gatatgcgga tctgaaaaga acaattgctg      300

tccttctgga tgacattttg caacgattgg tgaagctgga gaacaaagtt gactatattg      360

ttgtgaatgg ctcagcagcc aacaccacca atggtactag tgggaatttg gtgccagtaa      420

ccacaaataa aagaacgaat gtctcgggca gtatcagata gcagttgaaa atcaccttgt      480

gctgctccat ccactgtgga ttatatccta tggcagaaaa gctttataat tgctggctta      540

ggacagagca atactttaca ataaaagctc tacacatttt caaggagtat gctggattca      600

tggaactcta attctgtaca taaaaatttt aaagttattt gtttgctttc aggcaagtct      660

gttcaatgct gtactatgtc cttaaagaga atttggtaat ttggttgatg tggtaagcag      720

ataggtgagt tttgtataaa tcttttgtgt ttgagatcaa gctgaaatga aaacactgaa      780

aaacatggat tcatttctat aacacattta tttaagtata taacacgttt tttggacaag      840

tgaagaatgt ttaatcattc tgtcatttgt tctcaataga tgtaactgtt agactacggc      900

tatttgaaaa aatgtgctta ttgtactata ttttgttatt ccaattatga gcagagaaag      960

gaaatataat gttgaaaata atgttttgaa atcatgaccc aaagaatgta ttgatttgca     1020

ctatccttca gaataactga aggttaatta ttgtatattt ttaaaaatta cacttataag     1080

agtataatct tgaaatgggt agcagccact gtccattacc tatcgtaaac attggggcaa     1140

tttaataaca gcattaaaat agttgtaaac tctaatctta tacttattga agaataaaag     1200

atatttttat gatgagagta acaataaagt attcatgatt tttcaaaaaa aaaaaaaaaa     1260

a                                                                     1261


<210>  119
<211>  1977
<212>  DNA
<213>  Homo sapiens

<400>  119
tgaagtgggc agatggcaaa atgatcaaga atgaagtgga catgcaggtc ctccaccttc       60

tgggccccaa gttggaggct gatctggaga agaagttcaa ggtggcaaaa gctcggctag      120

aagaaacaga ccggaggacg gcaaaggatg tggtggagaa tggcgagact gctgaccaga      180

ccctgtctct gatggagcag ctccgggggg aggcccttaa gttccacaag cctggtgaga      240

actacaagac cccaggctat gtggtcactc cacacaccat gaatctacta aagcagcacc      300

tggagattac tggtgggcag gtacgtaccc ggttcccgcc agaacccaat ggaatcctgc      360

atattggaca tgccaaagcc atcaatttca actttggcta tgccaaggcc aacaatggca      420

tctgttttct gcgttttgat gacaccaacc ctgagaagga ggaagcaaag ttcttcacgg      480

ccatctgtga catggtagcc tggctaggct acacacctta caaagtcaca tatgcgtctg      540

actattttga ccagctatat gcgtgggctg tggagctcat ccgcaggggt ctggcttatg      600

tgtgccacca gcgaggagag gagctcaaag gccataatac tctgccttca ccctggagag      660

accgtcccat ggaggagtca ctgctgctct ttgaggcaat gcgcaagggc aagttttcag      720

agggcgaggc cacactacgg atgaagctgg tgatggagga tggcaagatg gaccctgtag      780

cctatcgagt caagtataca ccacaccacc gcacagggga caaatggtgc atctatccca      840

cctacgacta cacacactgc ctctgtgact ccatcgagca catcactcac tcactctgca      900

ccaaggaatt ccaggcccga cgctcttcct acttctggct ttgcaatgca ctggacgtct      960

attgccctgt gcagtgggag tatggccgcc tcaacctgca ctatgctgtt gtctctaaga     1020

ggaagatcct ccagcttgta gcaactggtg ctgtgcggga ctgggatgac ccacggctct     1080

ttacactcac ggccctgcga cggcggggct tcccacctga ggccatcaac aacttctgtg     1140

cccgggtggg agtgactgtg gcacaaacca caatggagcc acatcttcta gaagcctgtg     1200

tgcgtgatgt gctgaatgac acagccccac gagccatggc tgtgctggag tcactacggg     1260

tcatcatcac caactttcct gctgccaagt ccttggacat ccaggtgccc aacttcccag     1320

ctgatgagac caaaggcttc catcaggttc cctttgcacc cattgtcttc attgagagga     1380

ctgacttcaa ggaggagcca gagccaggat ttaagcgcct ggcttggggc cagcctgtgg     1440

gcctgaggca tacaggctac gtcattgagc tgcagcatgt tgtcaagggc cccagtggtt     1500

gtgtagagag tctggaggtg acctgcagac gggcagatgc tggagagaag ccaaaggcct     1560

ttattcactg ggtgtcacag cctttgatgt gtgaggttcg cctctatgag cgactattcc     1620

agcacaagaa ccctgaagat cctactgagg tgcctggtgg atttttaagt gacctgaacc     1680

tggcatcact acacgtggtg gatgcagcat tagtggactg ctctgtggcc ctggcaaaac     1740

ccttcgacaa gttccagttt gagcgtcttg gatatttctc cgtggatcca gacagccatc     1800

agggaaagct tgtctttaac cgaactgtca cactgaagga agacccagga aaggtgtgag     1860

ctggaagcac tgaacctacc tcatcctcct ggagggtgtg gctaccctcg ccaccccaaa     1920

ttccatgtca ataaagaaca gctaaattct cctagaaaaa aaaaaaaaaa aaaaaaa        1977


<210>  120
<211>  1361
<212>  DNA
<213>  Homo sapiens

<400>  120
cgcggggatg gagcccctgc gggtgctgga gctatacagc ggcgtgggcg gcatgcacca       60

cgcgctgaga gaaagctgta tacctgcaca agtggtggct gccattgatg tcaacactgt      120

cgctaatgaa gtatacaagt ataattttcc tcacacacag ttacttgcca agacaattga      180

aggcattaca ctcgaagagt ttgacagatt atctttcgat atgattttaa tgagccctcc      240

ctgccagcca ttcacaagga ttggccggca gggtgatatg actgattcaa ggacgaatag      300

cttcttatat attctagata ttctcccaag attacaaaaa ttaccaaagt atattctttt      360

ggaaaatgtt aaaggttttg aagtatcttc tacaagagac ctcttgatac aaacaataga      420

aaattgtggc tttcagtacc aagagtttct attatctcca acctctcttg gcattccaaa      480

ttcaaggcta cgatattttc ttattgcaaa gcttcagtca gagccattac cctttcaagc      540

ccctggtcag gtacttatgg agttccccaa aattgaatct gtacatccac aaaaatatgc      600

aatggatgta gaaaataaaa ttcaagaaaa gaacgttgaa ccaaatatta gctttgatgg      660

cagcatacag tgttctggaa aagatgccat tctttttaag cttgaaactg cagaagaaat      720

tcacaggaaa aatcaacaag atagtgatct ctctgtgaaa atgctaaaag attttcttga      780

agatgacact gacgtgaacc agtatctttt accaccaaag tcattgctgc gatatgctct      840

tctgttagac attgttcagc ccacttgtag aaggtccgtg tgctttacca aaggatatgg      900

aagctacata gaagggacag ggtctgtgtt acagactgca gaggatgtgc aggttgagaa      960

tatctacaaa tcccttacca atttgtcaca agaagaacag ataacaaagc tgttaatact     1020

taaactgcga tatttcactc ctaaagaaat agcaaatctc cttggatttc ctccagagtt     1080

cggatttcct gagaagataa cagtgaaaca gcgttatcgc ctacttggaa atagtctcaa     1140

cgtgcatgta gtagctaaac taatcaaaat cttatatgaa taattttgaa ataactctga     1200

aagatggtca tatgatattc cttcattttc agagagtaat tctgaaattc tgttttgaac     1260

taattctggt gaaatttaac taaattattt taatctgtcc ttattaagaa atttggattt     1320

tattaaaaaa atccatgtgt ttcatcaaaa aaaaaaaaaa a                         1361


<210>  121
<211>  1564
<212>  DNA
<213>  Homo sapiens

<400>  121
agaaagaaaa ggtgtagtgt ttggggaggt caacgggcta tgctggcttg acagggctgg       60

gctcttcaga acagaagcat ggatctcgga atccctgacc tgctggacgc gtggctggag      120

cccccagagg atatcttctc gacaggatcc gtcctggagc tgggactcca ctgcccccct      180

ccagaggttc cggtaactag gctacaggaa cagggactgc aaggctggaa gtccggtggg      240

gaccgtggct gtggccttca agagagtgag cctgaagatt tcttgaagct tttcattgat      300

cccaatgagg tgtactgctc agaagcatct cctggcagtg acagtggcat ctctgaggac      360

ccctgccatc cagacagtcc ccctgccccc agggcaacca gttctcctat gctctatgag      420

gttgtctatg aggcaggggc cctggagagg atgcaggggg aaactgggcc aaatgtaggc      480

cttatctcca tccagctaga tcagtggagc ccagcattta tggtgcctga ttcctgcatg      540

gtcagtgagc tgccctttga tgctcatgcc cacatcctgc ccagagcagg caccgtagcc      600

ccagtgccct gtacaaccct gctgccctgt caaaccctgt tcctgaccga tgaggagaag      660

cgtctgctgg ggcaggaagg ggtttccctg ccctctcacc tgcccctcac caaggcagag      720

gagagggtcc tcaagaaggt caggaggaaa atccgtaaca agcagtcagc tcaggacagt      780

cggcggcgga agaaggagta cattgatggg ctggagagca gggtggcagc ctgttctgca      840

cagaaccaag aattacagaa aaaagtccag gagctggaga ggcacaacat ctccttggta      900

gctcagctcc gccagctgca gacgctaatt gctcaaactt ccaacaaagc tgcccagacc      960

agcacttgtg ttttgattct tcttttttcc ctggctctca tcatcctgcc cagcttcagt     1020

ccattccaga gtcgaccaga agctgggtct gaggattacc agcctcacgg agtgacttcc     1080

agaaatatcc tgacccacaa ggacgtaaca gaaaatctgg agacccaagt ggtagagtcc     1140

agactgaggg agccacctgg agccaaggat gcaaatggct caacaaggac actgcttgag     1200

aagatgggag ggaagccaag acccagtggg cgcatccggt ccgtgctgca tgcagatgag     1260

atgtgagctg gaacagacct tcctggccca cttcctgatc acaaggaatc ctgggcttcc     1320

ttatggcttt gcttcccact gggattccta cttaggtgtc tgccctcagg ggtccaaatc     1380

acttcaggac accccaagag atgtccttta gtctctgcct gaggcctagt ctgcatttgt     1440

ttgcatatat gagagggtac ctcaaatact tctgttatgt atctgtgatt ttatttcttc     1500

tttgggtata gggttgaggg gaaataagtt ttgagtgaga aataaacgtt ttagctgaaa     1560

ttgt                                                                  1564


<210>  122
<211>  1999
<212>  DNA
<213>  Homo sapiens

<400>  122
agtggcaaga tggcgtccct ggatcgggtg aaggtactgg tgttgggaga ctcaggtgtt       60

gggaaatctt cgttagtcca tctcctatgc caaaatcaag tgctgggaaa tccatcatgg      120

actgtgggct gctcagtgga tgtcagagtt catgattaca aagaaggaac cccagaagag      180

aagacctgct acatagaatt atgggatgtt ggaggctctg tgggcagtgc cagcagcgtg      240

aaaagcacaa gagcagtatt ctacaactcc gtaaatggta ttattttcgt acacgactta      300

acaaataaga agtcctccca aaacttgcgt cgttggtcat tggaagctct caacagggat      360

ttggtgccaa ctggagtctt ggtgacaaat ggggattatg atcaagaaca gtttgctgat      420

aaccaaatac cactgttggt aatagggact aaactggacc agattcatga aacaaagcgc      480

catgaagttt taactacgac tgctttcctg gctgaggatt tcaatccaga agaaattaat      540

ttggactgca caaatccacg gtacttagct gcaggttctt ccaatgctgt caagctcagt      600

aggttttttg ataaggtcat agagaagaga tactttttaa gagaaggtaa tcagattcca      660

ggctttcctg atcggaaaag atttggggca ggaacattaa agagccttca ttatgactga      720

attacactca tcctttggaa gagtgagcaa gcagtggcag tttttcacag ctcatcttgc      780

tgtgttcaat tattaccatc acagcctttt aacaaaatca tcttaaaatg ctacccttca      840

gccttaccct ttaatggaaa aatgaaagga agtgacaata cgggaggtcc aaactttgtc      900

cctgttctct gtgttcctta cctttctgtc cctgtgtata gattatgtaa aagccttgtg      960

taaatatgag atgttgtcaa aatgatgcag taaatgagca atgacagtgt actgcagaga     1020

aaatttactc ttgcctagaa ctggagggtt tttatgggtc tgtaattttc ccacactcat     1080

tgctgaaagc ttaattaagt acttcaaaaa cgtatctcca ttgttttacc ttcttgaggg     1140

gaacggtctt gttaaccagc actgagttgt ctaccccaaa caatctctgt cattttcaaa     1200

gatgcaaaat ggtgttattt aattgtctcc accattgtca cacacaggaa tgcctaataa     1260

tagcaaccct tgtctccctc ttctctcctt tgcaaatggg tcagtgactg gaagaggcgg     1320

actaatagcc agagttaaat ataaatacaa attaataata catagagaac agcaatacca     1380

gaaaaaaaga attctggtaa aatgatgtga aaaattgaca gctccctcac tcttaaggtt     1440

gctgctatat acagtctagg ttttctgttt ggaaataggt agggtaaaat ctaagacctg     1500

cacaagggca gtgagagaca tttacagcct cctctctatt tgttttttta aggaaaagtc     1560

aactcctgaa atgtccctta gctataatca gaaaactaag aatattattc tgtgtcaaca     1620

atgtatttat ggagagaagt aaaaataagt tccacagcaa cacatttaca tgaattatga     1680

actaggattc ttggatttca taatcactcc aaagcttttt ggggatggtg tgtgtgtgtg     1740

tgtgtgtccg taattgttca tcattacttt ttttaaccta tctttttgct tgcttaatct     1800

tctctgcccc agttcttcct gagtatatga atttgatttc taaaaacaat ttattcaaca     1860

ctctatcacc cgtattctct ctctggctct gctgcaggtc tctgcactcc tgattttgct     1920

ccatactttt aaataacaat aataaatata cagttttcat ttctcatcta aaaaaaaaaa     1980

aaaaaaaaaa aaaaaaaaa                                                  1999


<210>  123
<211>  4530
<212>  DNA
<213>  Homo sapiens

<400>  123
ggcacgaggc tggggtggag ggcgggacag aggggctggg cccaggcaaa gcttctgtcg       60

ctgctgctgc ggaggccgag gacaggacgt gggctgggcc gggcagtgcc ggactcggag      120

gagcaggagg cgaggtccgc cggagctctg agcccccgct gctctgccgc gcggtgaccc      180

cgcgccccgg cgccgtccga cccgtggctg ttccgagacg attggtgggg gcgcggcggc      240

ggcggcggcg gctgttgggg gtggggagac gcgcggcgag gagacgagcg aggtcagcga      300

gtttgaggga ggaccgcgag ccgctgccgc cgtcatgtcc gaggactcga gcgccctgcc      360

ctggtccatc aacagggacg attacgagct gcaggaggtg atcgggagtg gagcaactgc      420

tgtagtccaa gcagcttatt gtgcccctaa aaaggagaaa gtggcaatca aacggataaa      480

ccttgagaaa tgtcaaacta gcatggatga actcctgaaa gaaattcaag ccatgagtca      540

atgccatcat cctaatattg tatcttacta cacatctttt gtggtaaaag atgagctgtg      600

gcttgtcatg aagctgctaa gtggaggttc tgttctggat attattaagc acattgtggc      660

aaaaggggaa cacaaaagtg gagtcctaga tgaatctacc attgctacga tactccgaga      720

agtactggaa gggctggaat atctgcataa aaatggacag atccacagag atgtgaaagc      780

tggaaacatt cttcttggag aagatggctc agtacagatt gcagactttg gggttagtgc      840

ttttttagca actggtggtg atattacccg aaataaagtg agaaagacct ttgttggcac      900

cccttgttgg atggcacctg aagttatgga acaggtccgt ggttatgatt tcaaagctga      960

tatttggagt tttggaatta cagcaattga attggctaca ggggcggctc cttatcataa     1020

atatccacca atgaaggttt taatgctgac actgcagaac gatcctcctt ctttggaaac     1080

tggtgttcaa gataaagaaa tgctgaaaaa atatggaaaa tcatttagaa aaatgatttc     1140

attgtgcctt caaaaagatc cagaaaaaag accaacagca gcagaactat taaggcacaa     1200

atttttccag aaagcaaaga ataaagaatt tcttcaagaa aaaacattgc agagagcacc     1260

aaccatttct gaaagagcaa aaaaggttcg gagagtacca ggttccagtg ggcgtcttca     1320

taagacagag gatggaggct gggagtggag tgatgatgaa tttgatgaag aaagtgagga     1380

agggaaagca gcaatttcac aactcaggtc tccccgagtg aaagaatcaa tatcaaattc     1440

tgagctcttt ccaacaactg atcctgtggg tactttgctc caagttccag aacagatctc     1500

tgctcatcta cctcagccag ctgggcagat tgctacacag ccaactcaag tctctctccc     1560

acccaccgca gagccagcaa aaacagctca ggctttgtct tcaggatcag gttcacaaga     1620

aaccaagatc ccaatcagtc tagtactaag attaaggaat tccaaaaaag aactaaatga     1680

tattcgattt gaatttactc ctgggagaga tacagcagag ggtgtctctc aggaactcat     1740

ttctgctggc ctggtcgacg gaagggattt agtaatagtg gcagctaatt tgcagaaaat     1800

tgtggaagaa cctcagtcaa atcgatctgt cactttcaaa ctggcatctg gtgtcgaagg     1860

ctcagatatt cctgatgatg gtaaactgat aggatttgcc cagctcagca tcagctaaac     1920

cacaaccctg gaagaggcgg cctaaggaga ttccacacat gcgtatctct gttgcttcta     1980

ttggcctaaa cccactactg ccaaagaacc cagcaacaaa cctcccggct aggagcttta     2040

gaagtcttta tgttcttcct gccatcattc ctccttttcc cacagggaaa gaaaagttgg     2100

atcactagtg gccagcatcc ccagagttcc gttagtaaac ttacttcata tgtcccctgt     2160

cttcctccat ctgagaagtg gcccatgtgc ttcaaggccc aggagggaga tctgtcagct     2220

cattcttgcc ttactccaat gatggcccag gtggaaaagt agcagctgta tcgggcttcc     2280

tcatcctgcc tgttccccca cacctgccag gatatggaca tcttgggata tctctttacc     2340

actgaagtag aattgattgt tcagctggag cccagagaat ttaatttaat gttttttctt     2400

tgtacctgat gtgaattcta gcaacctttg ttaggaaaaa gcacagcctc agatggaggc     2460

agcctaaact gtgttcttgt tttgttcatg gtgtttctaa gcgttttgct gaagctgctc     2520

tcaggcaccc ccttcttcat tgctctctcc agaaagggtt gctagcctta acttcagctg     2580

gtgcaaaaca tctgactgta gccgaacttc agccatcaga tccttcaaag tggaactttg     2640

gattgttttt acagacaaca tcgagtaatg gcttgtaaat gtgaattttg ccagaggtgg     2700

tttttgaaca ggaaaatcat aattcatatc attggagaag tatttatttt caaatatcaa     2760

attgaagaaa aactcaatcc tcccatgaaa atcagttcgc ctggcctcca agtcgtgagg     2820

aaatgggtat gcaaggctga gatttctaca gcaataaagg agacacacac tgggccagag     2880

aggcctgcct tctgcctgct ctcctgcact gaccctttgg agggggtctc tgtgtgctga     2940

agctaactca agatggaaag tgaaaccaca tgtgccgtga cctttaggtt ttatgagtag     3000

acagtgttca tttgattttc tacagaaata atataaatta ttctttaggt ttaaaaaaga     3060

gcactcataa tgcaatatgt gaataatcag tgaggttgat ttttcttttt tcctaccgtt     3120

tcatagtctt tgtctaactg ctagtaaccc taccgagttt tatatatgag tgggatactc     3180

aatctggcct taaaaagata cacaaagatg ggctgtgggt ccctggaaag ggggagagtt     3240

gccctttaca gaatcactcg agccctttcc agcactgttg gtctgatgaa caaggttgtt     3300

ttaccttatt ttctcttgga acatatctga aaaccttccc cacaaataac ttgtcacacc     3360

ttttgtttca ttctgagtct ttagttttag tcatgggctt tcttcacctg ctctaggtgc     3420

aaaggcatgt tgggaaagag atggatgttg gggaggaaga gaggagatgg atttcagttg     3480

ggagttagga ggagagtagg tgagatgatc agacaccgga gttcaacgtc ccagcagtct     3540

tggtaaaagg agggagcctg ctgagccagg agggagaaaa gaagattgac cagcttgcta     3600

gaaaaatact tagcttttct ttttcttttt ttgtggaggg gggacggaga ggaacaagga     3660

tggggaggta ggaatgaggt atagaaaaga gatagcatct tctttggcac aagactagtg     3720

gcttaccgct taccttagag ttttgttttt tttttttcaa acccatcaaa atctacttat     3780

ttatgaatcc aaggggtggc agcatcactc tgttctagca ttctttgtgg agatggtctg     3840

gtgcctagct gggagtgagc agcagcccat cccctgttca ctttctctag cccatcatta     3900

cctgtgaact gcagtggggc agtcatggca aatagaattg ggctggggtt tctccttctt     3960

ttcagttcat tgtttgccct gctaggaatt agaagacaga caccatgtcc caggacagtg     4020

ttacttcttc tgcatgatgt gtggtagact ccctttgctg gcttgtgcag tgatactgag     4080

aaaatacatg aacagaaact gcccaggtgg aacagcacgt aacctagtga gtgactgtac     4140

tcctttctag gaatgctgat tcagagtgca cctctttgac taggtcccag gatccccttg     4200

tccctggagt agggactaac tatagcacaa agtaatatgt gccaatgcta tttgtgaaat     4260

gtttggtctt tctaaacgac taaaggattt gttgggtttt tgcttaagtt ttgaaccaaa     4320

tcctagagcc agctgataat atttaataat ctagaggaga gaataatgat gtaccaataa     4380

gtggagattc ctccttatga tgtatgctag gttatggaag atgtaaaata ttcaactttt     4440

tcctcctttt tttggacttt gtattttact gcatgttttc ttcattttta atcaataaag     4500

agtaaattgt caaaaaaaaa aaaaaaaaaa                                      4530


<210>  124
<211>  1520
<212>  DNA
<213>  Homo sapiens

<400>  124
gggaccactg agtccagaag caagacctgt gagagtgcac agtgccactt cgccccatgg       60

ctgaagatgg tttgcccaaa atttattctc atcctccaac agaaagcagt aaaacaccaa      120

ctgcagcaac cattttcttt ggggctgaca atgctattcc caaatcagaa acaactatta      180

cttcagaagg agaccacgtc acttcagtaa atgaatatat gctagaaagc gatttttcaa      240

caactacaga caacaaactg acagctaaaa aggaaaaact caaatcagaa gatgatatgg      300

ggaccgactt tattaagtca acaactcacc tacagaaaga aattacctct ctgactggca      360

ctacaaactc cataacaaga gactctatta ccgaacattt catgccagtg aaaattggga      420

atatttcatc accagttact actgtttctt taatagattt ttccactgac atagcaaaag      480

aagatatcct cttagctacc attgacacag gagatgcaga gatctcaata acctctgaag      540

tctctggcac actaaaggac agcagtgctg gtgttgctga cgctcctgcc tttccacgta      600

aaaaggatga agctgatatg agcaattata attcctccat caaatccaat gtccctgctg      660

atgaggctgt ccaggtcact gattccacta ttcctgaggc tgaaatccct cctgctcctg      720

aagaaagctt cactactatt ccagacataa ctgcccttga agaagagaaa ataaccgaaa      780

ttgacctaag tgttttagaa gatgacacca gtgctgtggc tacattaact gactctgatg      840

agaagtttat cactgtgttt gaactcacta cctctgctga aaaagacaaa gataaacggg      900

aagatactct gctaactgat gaagaaacta ccgagggagc cagtatttgg atggagagag      960

atactgcaaa tgaagcagag acccattctg ttttgcttac tgctgttgaa tccagatatg     1020

acttcgttgt ccctgcatca atagctacaa acctagtgga agaatcatct acagaagaag     1080

atttgtctga aactgataat acagagactg tacctaagat cactgagcca ttttctggaa     1140

ctacctctgt attagatacc ccagactata aggaagacac ctccacaact gaaacggata     1200

tctttgaact actgaaagaa gaacccgatg agttcatgat ttaaaagcaa caaaagggat     1260

accatgtaga attgtgcaat agtctagcca gctagcctta acatctaaga aatttttcca     1320

acaagcaaaa acctttagaa atgaaagaat gtgggcattt aaggtcttaa acactgaata     1380

tcacactctt cttatgactc ttgttagcga ttcaaggaca taaatcttca ttcttttctg     1440

gcacagacta cttaaatggg tctgttttca ctttgctcat ttttcttcaa taaatctttt     1500

tggcaagcaa aaaaaaaaaa                                                 1520


<210>  125
<211>  1500
<212>  DNA
<213>  Homo sapiens

<400>  125
ggcacgaggg tcgcgagtgc tggtgtccga catccttcaa agttgagccc tttttttccg       60

ctgtgagtct ctacacatgt ctgacactct catgtcccac ggattacaga aagacattcc      120

ttgcaggaga acatggcttc ccagtgatgt gggaaagatg gactctgatc tccagggtag      180

aagtggcaac cagagtaagc cagttcgttg aagcaaatga tggctgcagt gaagagtacc      240

gaggcacacc catcctcaaa caaggatccc acacagggcc agaaatcagc cctccagggt      300

aacagccctg actccgaggc ctcccgtcag cgcttcaggc agttttgcta ccaggaggta      360

actggcccac atgaagcttt tagcaaactc tgggaactct gttgtcagtg gctgaggccg      420

aagacccact caaaagagga aatcctggag ctgctggttt tggagcagtt tctgactatc      480

ttgccagagg agatccagac ctgggtgagg gagcagcatc cagaaaacgg cgaggaagct      540

gtggctctgg ttgaggatgt acagagagct cctggacaac aggttctaga ttctgagaag      600

gacttgaaag tactcatgaa ggagatggcc cctttgggag caaccagaga atcactgaga      660

tcccaatgga aacaggaggt tcagccagag gaaccgactt ttaagggatc acagagctca      720

caccaaagac caggggaaca gtcagaagcc tggcttgctc ctcaggctcc caggaacctg      780

cctcaaaaca caggtctcca cgaccaggag acaggtgctg tggtctggac agctgggtcc      840

cagggaccag ccatgcgtga caacagagct gtatccctct gtcagcaaga atggatgtgc      900

ccaggccctg cacaaagggc cctctacagg ggtgccaccc agaggaagga cagtcacgtc      960

tcgctggcaa caggtgccct ggggctatga agagaccaag acgctcctgg ctattcttag     1020

tagttctcaa ttttatggaa aactccagac ctgtcagcag aacagccaga tctacagggc     1080

catggcggaa ggactctggg agcagggttt tctgcggacc ccagaacagt gtcgcaccaa     1140

gttcaaaagc ctacagttga gttaccgcaa agtgaggaga ggccgtgtgc ctgagccttg     1200

tatcttttat gaggaaatga atgctctttc aggctcctgg gcctctgcac ctcctatggc     1260

aagcgatgct gttcctggcc aagaaggaag tgatattgag gctggagagc tgaatcacca     1320

gaatggggaa cccacggagg tagaagatgg cactgtggat ggtgcagaca gggatgaaaa     1380

ggacttcagg aatcctggcc aggaagtcag gaaactagac ctgccagtgc tgttcccaaa     1440

cagacttggt tttgagttca agaacgagat taaaaaaaaa aaaaaaaaaa aaaaaaaaaa     1500


<210>  126
<211>  2466
<212>  DNA
<213>  Homo sapiens

<400>  126
gggataatgc tcccgagaag gattctggca gcagttctca aaggctagac ttgagtggta       60

ttgctgcata tgcgctgatt cttcagcttg tctctaaccg aggaagcatt gattgggagc      120

tactcattca gaaaattaaa agaaagaagc cagaaaatat tatcaaccct ttgagaacac      180

gacacaacga actttatatt ttaccacttc cttgaatagt tgcaggagaa ataacaaggc      240

attgaagaat ggcagatgaa cggaaagacg aagcaaaggc acctcactgg acctcagcac      300

cgctaacaga ggcatctgca cactcacatc cacctgagat taaggatcaa ggcggagcag      360

gggaaggact tgtccgaagc gccaatggat tcccatacag ggaggatgaa gagggtgcct      420

ttggagagca tgggtcacag ggcacctatt caaataccaa agagaatggg atcaacggag      480

agctgacctc agctgacaga gaaacagcag aggaggtgtc tgcaaggata gttcaagtag      540

tcactgctga ggctgtagca gtcctgaaag gtgaacaaga gaaagaagct caacataaag      600

accagactgc agctctgcct ttagcagctg aagaaacagc taatctgcct ccttctccac      660

ccccatcacc tgcctcagaa cagactgtca cagtggagga agcagcaggt ggggaatcag      720

ctctggctcc cagtgtattt aaacaggcaa aggacaaagt ctctgacgga gtaaccaaga      780

gcccagaaaa gcgctcttct ctcccaagac cttcctccat tctccctcct cggcgaggtg      840

tgtcaggaga cagagatgag aattccttct ctctcaacag ttctatctct tcttcagcac      900

ggcggaccac caggtcagag ccaattcgca gagcagggaa gagtggtacc tcaacaccca      960

ctacccctgg gtctactgcc atcactcctg gcaccccacc aagttattct tcacgcacac     1020

caggcactcc tggaacccct agctatccca ggacccctca cacaccagga acccccaagt     1080

ctgccatctt ggtgccgagt gagaagaagg tcgccatcat acgtactcct ccaaaatctc     1140

ctgcgactcc caagcagctt cggcttatta accaaccact gccagacctg aagaatgtca     1200

aatccaaaat cggatcaaca gacaacatca aataccagcc taaagggggg caggtacaaa     1260

ttgttaccaa gaaaatagac ctaagccatg tgacatccaa atgtggctct ctgaagaaca     1320

tcggccacag gccaggtggc ggacgtgtga aaattgagag tgtaaaacta gatttcaaag     1380

aaaaggccca agctaaagtt ggttctcttg ataatgctca tcatgtacct ggaggtggta     1440

atgtcaagat tgacagccaa aagttgaact tcagagagca tgctaaagcc cgtgtggacc     1500

atggggctga gatcattaca cagtccccag gcagatccag cgtggcatca ccccgacgac     1560

tcagcaatgt ctcctcgtct ggaagcatca acctgctcga atctcctcag cttgccactt     1620

tggctgagga tgtcactgct gcactcgcta agcagggctt gtgaatattt ctcatttagc     1680

attgaaataa taatatttag gcatgagctc ttggcaggag tgggctctga gcagttgtta     1740

tattcattct ttataaacca taaaataaat aatctcatcc ccaaactgta gtaattgtta     1800

caattttcta tttaaaaaat gaatagtaca tgcagaaatt gacctgattt ccatttgcaa     1860

caggaagaca ctggctttac atgggttcaa ttggacaatt atttttgctc tgctctgttt     1920

tgcatggagt attattattt taaaaattgc atttttacct ttcatgtgcc tgaaggctat     1980

ccactacatt ctgaaggcct tgttaaaatc caagctgctc atttcactat tctgtttctg     2040

agtgagaaga taaaaactgc ccattgtaac ttatttcagg ttaaattaaa ccaaggagtc     2100

tgattgcagg aagggaagag catgtaagaa ataagttttt ttaaagtgtt attttgtata     2160

aatgggaaga aagattcaat taagttatta acatttggga cctggataat tatatcagag     2220

tatgtcagtc caataaatta tttaactaat taaaaaatag ttgcaaagca tttgagctgt     2280

ggttgaggaa gtggtgttta gaatgtcagt tgatcagcta gatttgtgtc cacactacca     2340

gtttcacccc ccctttcatc tgtttgatac agtattatag atataaatat atatatattt     2400

ctctgaggcc atttgggata cttcctcata tactcgaata ttataacttc ttattcacag     2460

gatctg                                                                2466


<210>  127
<211>  1266
<212>  DNA
<213>  Homo sapiens

<400>  127
ctctcccgcg gaattcaggt ttacggccct gcgggttctc agagaatttc tagaatttgg       60

aatcgagtgc attttctgac atttgagtac agtacccagg ggttcttgga gaagaacctg      120

gtcccagagg agcttgactg accataaaaa tgagtactgc agatgcactt gatgatgaaa      180

acacatttaa aatattagtt gcaacagata ttcatcttgg atttatggag aaagatgcag      240

tcagaggaaa tgatacgttt gtaacactcg atgaaatttt aagacttgcc caggaaaatg      300

aagtggattt tattttgtta ggtggtgatc tttttcatga aaataagccc tcaaggaaaa      360

cattacatac ctgcctcgag ttattaagaa aatattgtat gggtgatcgg cctgtccagt      420

ttgaaattct cagtgatcag tcagtcaact ttggttttag taagtttcca tgggtgaact      480

atcaagatgg caacctcaac atttcaattc cagtgtttag tattcatggc aatcatgacg      540

atcccacagg ggcagatgca ctttgtgcct tggacatttt aagttgtgct ggatttgtaa      600

atcactttgg acgttcaatg tctgtggaga agatagacat tagtccggtt ttgcttcaaa      660

aaggaagcac aaagattgcg ctatatggtt taggatccat tccagatgaa aggctctatc      720

gaatgtttgt caataaaaaa gtaacaatgt tgagaccaaa ggaagattag aactcttggt      780

ttaacttatt tgtgattcat cagaacaggg tataggattg attgaaaaga agacagactt      840

gaagaagcaa gatttattat ctgatcactg cagtaaaaat gtgaggtggt gacagtgatg      900

gcaatgaaac agaaatggga gggacacacc ggagaagttg tcagggaaga actcaaagga      960

tttggggcct gattatataa tttattacag ttgtcccttg gtatccacgg ggggtgttcg     1020

gtccaggacc taaaatcctg ggatgctgaa atcccttgaa taaaatggta tagcatttgc     1080

atataaccta catatatcct cctatgtact ttaaatcatc tctagattac ttgtaatacc     1140

tgatacaatg taaatactgt ttaaatagtt gttatactgt attgctttaa aaatttatat     1200

ttttcgttgt taaaaaaaaa aaaaaaaaaa aaaacgaaaa aaaaaaaaaa aaaaaaaaaa     1260

aaaaaa                                                                1266


<210>  128
<211>  2504
<212>  DNA
<213>  Homo sapiens

<400>  128
ccattctccg cagagttgga gcacacagct gtattaaaaa ggcaaatcga aggccgggcg       60

cggtgactca cgcctgtcat cctagcactt tgggaggccg aggcggctga atcacttgag      120

gttaggagtt tgagatcagc ccgggcaaca tggtgaaacc ccgtctctac aaaaatagaa      180

aaattagccg agcgtgatgg tggatgcctg taatcctagc tcttcgggag gctaaggagt      240

ataatgtctc aggaaggcga ttatgggagg tggaccatat ctagtagtga tgaaagtgag      300

gaagaaaagc caaaaccaga caagccatct acctcttctc ttctctgtgc caggcaagga      360

gcagcaaatg agcccaggta cacctgttcc gaggcccaga aagctgcaca caagaggaaa      420

atatcacctg tgaaattcag caatacagat tcagttttac ctcccaaaag gcagaaaagc      480

ggttcccagg aggacctcgg ctggtgtctg tccagcagtg atgatgagct gcaaccagaa      540

atgccgcaga agcaggctga gaaagtggtg atcaaaaagg agaaagacat ctctgctccc      600

aatgacggca ctgcccaaag aactgaaaat catggcgctc ccgcctgcca caggctcaaa      660

gaggaggaag acgagtatga gacatcaggg gagggccagg acatttggga catgctggat      720

aaagggaacc ccttccagtt ttacctcact agagtctctg gagttaagcc aaagtataac      780

tctggagccc tccacatcaa ggatatttta tctcctttat ttgggacgct tgtttcttca      840

gctcagttta actactgctt tgacgtggac tggctcgtaa aacagtatcc accagagttc      900

aggaagaagc caatcctgct tgtgcatggt gataagcgag aggctaaggc tcacctccat      960

gcccaggcca agccttacga gaacatctct ctctgccagg caaagttgga tattgcgttt     1020

ggaacacacc acacgaaaat gatgctgctg ctctatgaag aaggcctccg ggttgtcata     1080

cacacctcca acctcatcca tgctgactgg caccagaaaa ctcaaggaac tcacctgtga     1140

gtgaatctct gatccaggag gagcctcact cagcctggga actttgaggt gctattgcaa     1200

ggggaggtcc tccacgtctg tccagcccaa cctggtcatt ttacacacgg aggcaaaggc     1260

ccagagagat cacagagctt acccaaaatg aatatggttg agccccttat acccacgaat     1320

tgctgatgga acccacaaat ctggagagtc gccaacacat tttaaagctg atctcatcag     1380

ttacttgatg gcttataatg ccccttctct caaggagtgg atagatgtca ttcacaagca     1440

cgatctctct gaaacaaatg tttatcttat tggttcaacc ccaggacgct ttcaaggaag     1500

tcaaaaagat aattggggac attttagact taagaagctt tgcataatta tcaaagcagg     1560

aaatgcagat cagtcttctg cagtgtttta gctgcttctg aaagaccatg cctcatccat     1620

gcctaacgca gagtcctggc ctgtcgtagg tcagttttca agcgttggct ccttgggagc     1680

cgatgaatca aagtggttat gttctgagtt taaagagagc atgctgacac tggggaagga     1740

aagcaagact ccaggaaaaa gctctgttcc tctttacttg atctatcctt ctgtggaaaa     1800

tgtgcggacc agtttagaag gatatcctgc tgggggctct cttccctata gcatccagac     1860

agctgaaaaa cagaattggc tgcattccta ttttcacaaa tggtcagctg agacttctgg     1920

ccgcagcaat gccatgccac atattaagac atatatgagg ccttctccag acttcagtaa     1980

aattgcttgg ttccttgtca caagcgcaaa tctgtccaag gctgcctggg gagcattgga     2040

gaagaatggc acccagctga tgatccgctc ctacgagctc ggggtccttt tcctcccttc     2100

agcatttggt ctagacagtt tcaaagtgaa acagaagttc ttcgctggca gccaggagcc     2160

aatggccacc tttcctgtgc catatgattt gcctccagaa ctgtatggaa gtaaagatcg     2220

gccatggata tggaacattc cttatgtcaa agcaccggat acgcatggga acatgtgggt     2280

gccctcctga gaatcttgag gcactgtgaa atttaagtgt aagacattga gccacaaaca     2340

tggaatctct tctttgtact ggatgtccac ttcccttaaa gtcttatttg cacccttaca     2400

aaatctttcc aaaggtcact cttatgaatg gatgttggtt atacttttaa tggacattaa     2460

cattcctaat aaagtattag tttcttaaaa aaaaaaaaaa aaaa                      2504


<210>  129
<211>  2949
<212>  DNA
<213>  Homo sapiens

<400>  129
gcgtaccttt ctccaggttt tcagcctgtg atttgataac cgccgccggg tggcgtggag       60

cgtcccgaga cttcttcctt cattgcagcc cctcttcttt tagttctaga ctgaagttcg      120

aggaacgcac cacttggctg aaattaggat ccagatttcc caaacttcct tcggaggaaa      180

aagccctaac gatggaggac agtgaattcc tagcttatgt ggaactacta gatgaagtgg      240

aacaaggctc agtgagagca aaagcatctt ctgttagtct acatgcagaa agaacctgga      300

tggagaaaat gaaagttgaa gacctaaatg tatgtgagcc tgcttctcct gcccctgaag      360

caccagctac ctctctgctg aatgacctca agtacagccc atcagaggaa gaggaggtga      420

catacacagt cattaatcaa ttccagcaga agtttggtgc tgcgatactc catatcaaga      480

agcagaatgt cctgagtgtg gcagcagaag gagcgaatgt atgtcgccat ggcaaactgt      540

gctggctgca ggtggccaca aattgccgag tttacttatt tgacattttc cttctgggaa      600

gtcgagcttt ccacaatgga cttcagatga tactagaaga caagagaatt ttgaaggtta      660

tccatgattg tcgttggctt tctgattgcc tctctcatca gtatggaatt ttgctgaata      720

atgtctttga cacacaggta gcagatgtac ttcagttttc catggaaacg ggtggctatc      780

ttccaaactg catcactact ttgcaggaga gtttaatcaa acaccttcaa gtagccccta      840

aatatctctc ctttctagaa aagagacaaa aactaattca ggaaaatcca gaagtatggt      900

tcatccgacc tgtttcaccc tctttactga aaattttggc cctggaagct acctacctgt      960

taccccttcg cttggcactc ctagatgaga tgatgtctga cctaaccacc ctggtggatg     1020

gttacctaaa cacgtatcgc gaagggtctg cagaccggct tggaggcact gagcctacat     1080

gtatggagct gccagaggaa ctgcttcaac tcaaggactt ccagaagcag cgcagggaga     1140

aagctgcaag agaatatagg gtgaatgcac agggactcct gataaggaca gtgctacagc     1200

caaagaaatt agtgacagag acagcaggga aagaggagaa agtcaaaggc ttcttatttg     1260

gtaaaaattt taggatagat aaagctccaa gttttacatc tcaagacttt cacggggatg     1320

tgaatttact gaaagaagaa tctttgaata aacaagctac aaatcctcaa catctacctc     1380

ccacggagga aggggaaact agtgaggatt ccagtaacaa actcatttgc acaaagtcaa     1440

aggggtcaga ggaccagaga ataactcaga aagaacactt tatgacaccc aaacatgagt     1500

ttcaggcaag tttatctttg aaagaggaga cagaacagtt attgatggtg gaaaacaagg     1560

aagatttaaa atgcacaaaa caggctgttt caatgtcttc ctttcctcag gaaaccagag     1620

tgtctccaag tgacactttt tatcctatca gaaagactgt ggtttccaca ctccctccct     1680

gtccagcctt ggagaagatc gattcctgga taagtccttt tctaaatctg ccctagagat     1740

gggcagtttg ttcttaaggc catgcagatg gcttatttcc tttgccatca gggctttcca     1800

cagtgcccag gtttctcatg ttgtaaatgt agtaatgctt cagtcacagg ggaaaattat     1860

atcctcttgc ttactcctgt gttcctggta tgcggagaat gagaatgaat aagttaaata     1920

atggaagaag tataatttct gattatgtca ctgtgtagaa atgttctcag tgaccagagt     1980

gcattatttt tcataatttg ggtttagagg atttgaagaa aggaagaatc ttgggcttag     2040

tatcaggaag actccatcat tttcaaattt tgttttgctt cttgactttt ggattccttt     2100

gaagagacct ggtaaaacta ttaacaattc atttaaaaaa ttggtacctg ataactttac     2160

cagtactttt ttccttttta tttatttgtt ttatttattt ttttttaccg ctccttgtgg     2220

agcagggcta caccataggc agtgtgccca gagtaaccac ttttttcctt tttaaaatat     2280

aatattaact ttatgtttga atgttgaatg ttttgtctgt ctcttaggca aataatgtta     2340

taggaatcaa taatttaatt tttgttttat ttgttttttg atggagtctc actctgtcac     2400

ccaggctgga gtgtagtggt gtaatctctg ctcactgcaa cctccgcctc ccgggttcaa     2460

gcaattctcc tgcctcagcc tcctgagtag ctgggattac aggtgcgtgc caccacgccc     2520

ggctaatttt tgtattttta gtagagatgg ggtttcacca tgttggccag gctggtctcg     2580

aactcctgac tgaccttgtg gtccacctgc cttggccttc caaagtgctg ggattacagg     2640

tgtgaggcac ggtgcccagc caatatcttt attttaattt gtttttattt cctttatttt     2700

tagctggttt tgtccatttt cctaacaaag cagggaccct gggtttcttt ttagtctgtc     2760

tgttatataa acttgaagcc tgactccatt ctatttgcct ggagttagta tactttctta     2820

gggtgaaagg aaggcagctt gtattgagcc ttttaaagta ttgaatgctt gcaaattgct     2880

aacattcttt tgtgtaaaat aaccaataaa cctgttttgt catactctac ttaaaaaaaa     2940

aaaaaaaaa                                                             2949


<210>  130
<211>  4336
<212>  DNA
<213>  Homo sapiens

<400>  130
gcggcggcgg cagcggcgga gaagggagcg ggaccggaag ggtcgcagcg ccccggcgcc       60

cctcacaccc actgcggcgg cggcggcggc ggcggcggcg gggcggagcg gagcggggcg      120

ggccggcggc ggagccgggg ccgcggagcc aggagtgact agcacgcagc gccgccagtc      180

cgcccgcccg ccctctcccc gtggcgcggc ggcggggagg cgagggatct gaaacttgcc      240

cacccttcgg gatattgcag gacgctgcat catgagcgac agtaaatgtg acagtcagtt      300

ttatagtgtg caagtggcag actcaacctt cactgtccta aaacgttacc agcagctgaa      360

accaattggc tctggggccc aagggattgt ttgtgctgca tttgatacag ttcttgggat      420

aaatgttgca gtcaagaaac taagccgtcc ttttcagaac caaactcatg caaagagagc      480

ttatcgtgaa cttgtcctct taaaatgtgt caatcataaa aatataatta gtttgttaaa      540

tgtgtttaca ccacaaaaaa ctctagaaga atttcaagat gtgtatttgg ttatggaatt      600

aatggatgct aacttatgtc aggttattca catggagctg gatcatgaaa gaatgtccta      660

ccttctttac cagatgcttt gtggtattaa acatctgcat tcagctggta taattcatag      720

agatttgaag cctagcaaca ttgttgtgaa atcagactgc accctgaaga tccttgactt      780

tggcctggcc cggacagcgt gcactaactt catgatgacc ccttacgtgg tgacacggta      840

ctaccgggcg cccgaagtca tcctgggtat gggctacaaa gagaacgttg atatctggtc      900

agtgggttgc atcatgggag agctggtgaa aggttgtgtg atattccaag gcactgacca      960

tattgatcag tggaataaag ttattgagca gctgggaaca ccatcagcag agttcatgaa     1020

gaaacttcag ccaactgtga ggaattatgt cgaaaacaga ccaaagtatc ctggaatcaa     1080

atttgaagaa ctctttccag attggatatt cccatcagaa tctgagcgag acaaaataaa     1140

aacaagtcaa gccagagatc tgttatcaaa aatgttagtg attgatcctg acaagcggat     1200

ctctgtagac gaagctctgc gtcacccata catcactgtt tggtatgacc ccgccgaagc     1260

agaagcccca ccacctcaaa tttatgatgc ccagttggaa gaaagagaac atgcaattga     1320

agaatggaaa gagctaattt acaaagaagt catggattgg gaagaaagaa gcaagaatgg     1380

tgttgtaaaa gatcagcctt cagatgcagc agtaagtagc aacgccactc cttctcagtc     1440

ttcatcgatc aatgacattt catccatgtc cactgagcag acgctggcct cagacacaga     1500

cagcagtctt gatgcctcga cgggacccct tgaaggctgt cgatgatagg ttagaaatag     1560

caaacctgtc agcattgaag gaactctcac ctccgtgggc ctgaaatgct tgggagttga     1620

tggaaccaaa tagaaaaact ccatgttctg catgtaagaa acacaatgcc ttgccctact     1680

cagacctgat aggattgcct gcttagatga taaaatgagg cagaatatgt ctgaagaaaa     1740

aaattgcaag ccacacttct agagattttg ttcaagatca tttcaggtga gcagttagag     1800

taggtgaatt tgtttcaaat tgtactagtg acagtttctc atcatctgta actgttgaga     1860

tgtatgtgca tgtgaccaca aatgcttgct tggacttgcc catctagcac tttggaaatc     1920

agtatttaaa tgccaaataa tcttccaggt agtgctgctt ctgaagttat ctcttaatcc     1980

tcttaagtaa tttggtgtct gtccagaaaa agtcgattta tgtgtattaa ttggccatca     2040

tgatgttatc atatcttatt cccttttatg ctatgattta ttctatcttt tgtatttcag     2100

aagacatata attaaatcta tttaataaat aaaaatatat agcttttctt agatttgtga     2160

tgtttggggc tgagaattat cacggctaaa accaagacac ttatgtggac atcttgtttt     2220

ctttaaactg tcttgtctgg gatgattgta cattcagctt tactgcacga tacaatttta     2280

agttttgctt agtgctgctt gaaatcctag ctaccttatc tcttttcttc ttggtcttct     2340

agacttctta tgaatttaaa atgctaccta gaacttcacc ttctttatta ggtgcgtaac     2400

actccatctt aattaaatat gatggcagat aggttcctgc atccatggcc taacgttgga     2460

gtggaatttt acaaaatgct cactagagat cactgcagtc atttcctaag tgcttccttt     2520

gccacagact ggcctgggtc ctttatttac cttccctcat tcactttccc tcggccaata     2580

ccacgttctt gattttcttt cttcactgga agaaagcaga taaactcctc tttggtctgt     2640

tttcagaggc caggctgatt cagatgcctg ttgctattgt tgctctccat tgttgggagg     2700

cattcctttt cacaagaatg ttctgggaaa ctcttcagag gacgtgaagg aaataccctg     2760

aagagtcatg attaactatt gactattttc tgatttaaaa ctgctcacct gaaattgata     2820

cttttagact ttacgatcag taaattattc agaattcatg aagatgctga gtatgttaag     2880

tgtcactgca ggaacggagc tgtggtgatc acgttttgcc tgcctgtgcc catgtctctt     2940

cccttgagct tattctgttg ctgattcata tcttgtgttc aattattttg gaagcttttc     3000

agtcgacatt ctgtagagtg tgttctgagg aggaactgtg ataagaaagt ttattataaa     3060

tattatgtaa aatatatggc tctctctgca ccagttatat cttattggtt ggtcatatca     3120

ctggaaactg gaacctttga ttagcaaaat taatattgaa ataagaaata gttcttttat     3180

attgtgtcat ttggacactt tcaagtacaa aatggtaata ataacttgga ttgaggcgga     3240

aacacctatt ttatggctat ctatctaaac atcttaaaat ggccttctct gtaatacact     3300

ttcttttaaa agacttcact aaatctatct ttaaaaggaa aaacaaaagg gagaggttga     3360

aaatgcgcga gctgccctgc actgtgtgat gctccctccc cgggagacgt ggacggggga     3420

cgaggcaccc gcagacgccc ttctgctcac tcgctcctct gtgcattcag cgagccactt     3480

gccacagatg gagcccgtga cggtgtggag ggtttcctgg aaaggccatc ttccaccagg     3540

tagaggcgag cgtgcctagg acaggccaca gggctccaca gaaatacctc accccagctt     3600

cagggttctc tctcctgagc ctagatttgc cagggtcttg gtgccacgca aatggtttca     3660

aactgatctc tatggataaa tgctgatgtt ggttaaagaa ctgaaaaatg tgctcaactg     3720

tttcatcttt tctattttat ttttgtaatt tatattgtac acaacccagg aagtaactat     3780

tttggacatg tatttttata aaccaggtaa tttactatta tcctggaatt tagactaggt     3840

ttgtttcatt tgttgactta gtttccagcc aagaaggaaa cgactgtctc ccccatgtcc     3900

aggtctcagt ttcaagggca gagtccagag agcagacaga gttctgtgag agcaggagag     3960

cagtctggaa accctggctg tgcataccgt gtcagccgtg ggcctggaga tgggagcagg     4020

tgagacgcag agccccagta ctgagaggag gaagccctct tacagggccc cttgcccacc     4080

ccaagtccgt gtctgaaaca cggagcgggt gctgcttcaa cccgcattta atgctgtgta     4140

agtagcgata accacgtacg agtctgtctg gttgatttct aatgtgactc ctctggtatt     4200

tcctcctggt aataaataca agtgtgacct ttcagattgc atatctcaaa agtaacattg     4260

ctaatgtttt ataataaaat atattatgtg tgttttggtt ggtgaaaata atacagacta     4320

cattttaaaa gataaa                                                     4336


<210>  131
<211>  3581
<212>  DNA
<213>  Homo sapiens

<400>  131
ggtagatgcg gctgtgacag cagcaaagaa tgacggccaa gggcgacagc aggggctggc       60

catgctgtaa aggggcttct tgggagggtc cagcctcagg aatcaagggg aactcctgag      120

ccgagaattc tgaagatctc ctccctccct gaagctgtgg gctgggccat cggaaaactt      180

tcagttttgt ttccttgcct gcaagaaacg aaactcaacc gaaagcctgc agagagcaga      240

acatggaagg agacttctcg gtgtgcagga actgtaaaag acatgtagtc tctgccaact      300

tcaccctcca tgaggcttac tgcctgcggt tcctggtcct gtgtccggag tgtgaggagc      360

ctgtccccaa ggaaaccatg gaggagcact gcaagcttga gcaccagcag gccaatgagt      420

gccaggagcg ccctgttgag tgtaagttct gcaaactgga catgcagctc agcaagctgg      480

agctccacga gtcctactgt ggcagccgga cagagctctg ccaaggctgt ggccagttca      540

tcatgcaccg catgctcgcc cagcacagag atgtctgtcg cagtgaacag gcccagctcg      600

ggaaagggga aagaatttca gctcctgaaa gggaaatcta ctgtcattat tgcaaccaaa      660

tgattccaga aaataagtat ttccaccata tgggtaaatg ttgtccagac tcagagttta      720

agaaacactt tcctgttgga aatccagaaa ttcttccttc atctcttcca agtcaagctg      780

ctgaaaatca aacttccacg atggagaaag atgttcgtcc aaagacaaga agtataaaca      840

gatttcctct tcattctgaa agttcatcaa agaaagcacc aagaagcaaa aacaaaacct      900

tggatccact tttgatgtca gagcccaagc ccaggaccag ctcccctaga ggagataaag      960

cagcctatga cattctgagg agatgttctc agtgtggcat cctgcttccc ctgccgatcc     1020

taaatcaaca tcaggagaaa tgccggtggt tagcttcatc aaaaggaaaa caagtgagaa     1080

atttcagcta gatttggaaa aggaaaggta ctacaaattc aaaagatttc acttttaaca     1140

ctggcattcc tgcctacttg ctgtggtggt cttgtgaaag gtgatgggtt ttattcgttg     1200

ggctttaaaa gaaaaggttt ggcagaacta aaaacaaaac tcacgtatca tctcaataga     1260

tacagaaaag gcttttgata aaattcaact tgacttcatg ttaaaaaccc tcaacaaacc     1320

aggcgtcgaa ggaacatacc tcaaaataat aagagccatc tatgacaaaa ccacagccaa     1380

catcatactg aatgagcaaa agctggagca ttactcttga gaagtagaac aaggcacttc     1440

agtcctattc aacatagtac tggaagtcct cgccacagca atcaggcaag agaaagaaat     1500

aaaaggcaac caaaaagaaa ggaagtcgaa gtatctctgt ttgcagacga tatgattcta     1560

tatctagaaa accccatgat cttggcccaa aagctcctag atctgataaa caacttcagc     1620

taactttcag gagacaaaat caatatacaa aatatggtag catttttata caccaacgac     1680

atccaagctg agagccaaat caagaatgca atcctattca caattgccac aaaaagaata     1740

aaatacctag gaatacagct aaccagggag atgaaagatc tctacaacaa aaattacaaa     1800

acactgctga aagaaatcag agatgacaca aatggaaaaa cattccatac ttatggatag     1860

gaagaatcaa tattgttaaa atggccatac tacccaaagc aatttataga ttcaatgcta     1920

ttcctatcaa actaccaata acattcttca cagaatcaga aaaaaaaagc attaaaattt     1980

atttgaaacc aaaaaagagc ccaaaaagcc aaagcaatcc taagcaaaaa gaacaaagct     2040

ggaggcatcg cattacccaa cttcaaacta tactacaggg ctacagtaac caaaactgca     2100

tgatactggt acaaaagcat ggtgctggta caaaagcaga cacatagatc aatggaacag     2160

aatagagggc ccagaaataa agctacacac ctacaaccat ctaatctttg acaaagttga     2220

caaaaatacg caatggggaa agaattcccc attcagtaag tggtactggg ataactagct     2280

agccatatgc agaggattga aactgaacca cttccttaca ccatatgcaa aaatcaactc     2340

aagatggatt aaagacttaa atgtaaaacc ccaaactata aaaactctgg aagataacct     2400

aggcaatacc attctggaca taggaacgga aaaagatttc atgacaaaga tcccaaaaat     2460

aattgtaacg aaagcaaaaa ttgacaaatg ggacatgatt aaacagaatt accatttgac     2520

tcagcaatcc cattattggt tatataccca aaggaatcta aatcattctg tcataaagac     2580

atatatacac aaatgttcac ggcagcacta tacacaatcg caaagtcagg gaatcaaact     2640

aaatgtccat cagtggtaga aaggataaag aaaatgtggt ggcagggagt ggtggctcat     2700

gtctgtaatc ccagcacttt gggaggctga ggcgggtggt tcacctgagg tcaggagttt     2760

gagaccagcc tggccaacat ggcgaaactc cgtctccgct aaaaatacga aaattagcca     2820

ggcgtggtgg cgagcacctg tcatcccagc tacttgggag gcctaggcgt gagaatcgct     2880

tgaacctgga aggtggtggt tgcagtgagc cgagatcctg ccactgcact ccagcctggg     2940

caaccaagcg agactctgcc ttaaaaaaaa aaaaaagaaa atgtggcaca tatacaccat     3000

ggaatactat gcagccataa aaaagaatgg gatcatgtcc tgtgcagcaa cgtggatgga     3060

gctggaagcc attatcctaa atgaactcac tcagaaacag aaaaccaaat accacatgtt     3120

ctcacttata agtagaagct aaacattgag tacacatgga tacaaagaag ggaaccgcag     3180

acactggggc ctacctgagg tcggagcatg gaaggagggt gaggatcaaa aaactaccta     3240

tctggtacta tgctttttat ctggatgatg aaataatctg tacaacaaac cctggtgaca     3300

tgcaatttac ctatatagca agcctacaca tgtgcccctg aacctaaaaa aaaagttaaa     3360

agaaaaacgt ttggattatt ttccctcttt cgaacaaaga cattggtttg cccaaggact     3420

acaaataaac caacgggaaa aaagaaaggt tccagttttg tctgaaaatt ctgattaagc     3480

ctctgggccc tacagcctgg agaacctgga gaatcctaca cccacagaac ccggctttgt     3540

ccccaaagaa taaaaacacc tctctaaaaa aaaaaaaaaa a                         3581


<210>  132
<211>  2097
<212>  DNA
<213>  Homo sapiens

<400>  132
ggcacgaggc gagcaccagg gcggcggcgg cggcggcggc ggcggcggcg gctggagcag       60

cccgggagga ggaggcggcg agaatggcag cggcgtcgtg ggcgcggcgg agatgagcgc      120

ccgcgacccc gggcccaggg cggcacagcc ggagtgggcg ggggtcccga tgcaggcccg      180

aggggggcca tggggcaggt cctgccggtc ttcgcccact gcaaagaagc tccgtctaca      240

gcctcctcaa ctcctgattc cacagaagga gggaacgacg actctgattt tcgagagctg      300

cacacagccc gggaattctc agaggaggac gaggaggaga ccacgtcgca ggactggggc      360

accccccggg agctgacctt ctcctacatc gcctttgatg gtgtagtggg ctccgggggc      420

cgcagggatt caactgcccg ccgcccccgc ccccagggcc gctcagtctc ggaaccacga      480

gaccagcacc ctcagcccag cctgggcgac agcttggaga gcatccccag cctgagccaa      540

tccccggagc ctggacgacg gggtgatcct gacaccgcgc ctccatccga gcgccctctg      600

gaagacctga ggcttcggtt ggaccatctg ggctgggtgg cccggggaac gggatccggg      660

gaggactctt ccaccagcag ctccaccccg ctggaagacg aagaacccca agaacccaac      720

agattggaga caggagaagc tggggaagaa ctggacctac gactccgact tgctcagccc      780

tcatcgcccg aggtcttgac tccccagctc agtccgggct ctgggacacc ccaggccggt      840

actccgtccc catcccgatc gcgagattcg aactctgggc ccgaagagcc attgctggaa      900

gaggaagaaa agcagtgggg gccactggag cgagagccag taaggggaca gtgcctcgat      960

agcacggacc aattagaatt cacggtggag ccacgccttc taggtaagca acgtgtatga     1020

agatgctgca ttggcccaca gaaggcaaaa gtggcggacc tgctgtactg gaaggacacg     1080

aggacgtcag gagtggtctt cacaggcctg atggtctccc tcctctgcct cctgcacttt     1140

agcatcgtgt ccgtggccgc gcacttggct ctgttgctgc tctgcggcac catctctctc     1200

agggtttacc gcaaagtgct gcaggccgtg caccgggggg atggagccaa ccctttccag     1260

gcctacctgg atgtggacct caccctgact cgggagcaga cggaacgttt gtcccaccag     1320

atcacctccc gcgtggtctc ggcggccacg cagctgcggc acttcttcct ggtagaagac     1380

ctcgtggatt ccctcaagct ggccctcctc ttctacatct tgaccttcgt gggtgccatc     1440

ttcaatggtt tgactcttct cattctggga gtgattggtc tattcaccat ccccctgctg     1500

taccggcagc accaggctca gatcgaccaa tatgtggggt tggtgaccaa tcagttgagc     1560

cacatcaaag ctaagatccg agctaaaatc ccagggaccg gagccctggc ctctgcagca     1620

gccgcagtct ccggatccaa agccaaagcc gaatgagaac ggtgtctctg cccgcaggac     1680

gcctgccccc agcccccgca gccctctggc cccctccatc tcttgtccgt tcccacccac     1740

ccccctcctc ggcccgagcc ttttcccggt gggtgtcagg atcactccca ctagggactc     1800

tgcgctaatt acctgagcga ccaggactac atttcccaag aggctctgct ccaggagtcc     1860

aggaaagacg aggcaccttg gccgcggggc ctgctgggac ttgtagttgc ctagacaggg     1920

caccaccctg cacttccgga cccgccgctg gaggcgccgt gaggcgttgg tgtctcctgg     1980

atgctactag ccccaacgcc ggggctttgc atggggccca ggggaggcct gagcttggat     2040

ttacactgta ataaagactc ctgtggaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaa        2097


<210>  133
<211>  1530
<212>  DNA
<213>  Homo sapiens

<400>  133
aatcctggaa caaggctaca gcgtcgaaga tccccagcgc tgcgggctcg gagagcagtc       60

ctaacggcgc ctcgtacgct agtgtcctcc cttttcagtc cgcgtccctc cctgggccgg      120

gctggcactc ttgccttccc cgtccctcat ggcgctgctc cgacgcccga cggtgtccag      180

tgatttggag aatattgaca caggagttaa ttctaaagtt aagagtcatg tgactattag      240

gcgaactgtt ttagaagaaa ttggaaatag agttacaacc agagcagcac aagtagctaa      300

gaaagctcag aacaccaaag ttccagttca acccaccaaa acaacaaatg tcaacaaaca      360

actgaaacct actgcttctg tcaaaccagt acagatggaa aagttggctc caaagggtcc      420

ttctcccaca cctgaggatg tctccatgaa ggaagagaat ctctgccaag ctttttctga      480

tgccttgctc tgcaaaatcg aggacattga taacgaagat tgggagaacc ctcagctctg      540

cagtgactac gttaaggata tctatcagta tctcaggcag ctggaggttt tgcagtccat      600

aaacccacat ttcttagatg gaagagatat aaatggacgc atgcgtgcca tcctagtgga      660

ttggctggta caagtccact ccaagtttag gcttctgcag gagactctgt acatgtgcgt      720

tggcattatg gatcgatttt tacaggttca gccagtttcc cggaagaagc ttcaattagt      780

tgggattact gctctgctct tggcttccaa gtatgaggag atgttttctc caaatattga      840

agactttgtt tacatcacag acaatgctta taccagttcc caaatccgag aaatggaaac      900

tctaattttg aaagaattga aatttgagtt gggtcgaccc ttgccactac acttcttaag      960

gcgagcatca aaagccgggg aggttgatgt tgaacagcac actttagcca agtatttgat     1020

ggagctgact ctcatcgact atgatatggt gcattatcat ccttctaagg tagcagcagc     1080

tgcttcctgc ttgtctcaga aggttctagg acaaggaaaa tggaacttaa agcagcagta     1140

ttacacagga tacacagaga atgaagtatt ggaagtcatg cagcacatgg ccaagaatgt     1200

ggtgaaagta aatgaaaact taactaaatt catcgccatc aagaataagt atgcaagcag     1260

caaactcctg aagatcagca tgatccctca gctgaactca aaagccgtca aagaccttgc     1320

ctccccactg ataggaaggt cctaggctgc cgtgggccct ggggatgtgt gcttcattgt     1380

gccctttttc ttattggttt agaactcttg attttgtaca tagtcctctg gtctatctca     1440

tgaaacctct tctcagacca gttttctaaa catatattga ggaaaaataa agcgattggt     1500

ttttcttaag gtaaaaaaaa aaaaaaaaaa                                      1530


<210>  134
<211>  1825
<212>  DNA
<213>  Homo sapiens

<400>  134
ggagtatagg gcttgaactg agagcctggc ctcccagaag gttttaatag acctacggca       60

cagaaattga cacagcccgg aaaagaccca caaagagaag cccaaccagc cagcccccag      120

gccgccccgc cagggaccca ccaatgaggc acagatggca gccgctgccg ccctagcccg      180

gctggagcag aagcagtccc gggcctgggg ccccacatcg caggacacca tccgaaacca      240

ggtgagaaag gaacttcaag ccgaagccac cgtcagcggg agccccgagg ccccagggac      300

caacgtggta tctgagccca gagaggaagg ctctgcccac ctggctgtgc ctggcgtgta      360

cttcacctgt ccgctcactg gggccaccct gaggaaggac cagcgggacg cctgcatcaa      420

ggaggccatt ctcttgcact tctccaccga cccagtggcc gcctccatca tgaagatcta      480

cacgttcaac aaagaccagg accgggtgaa gctgggtgtg gacaccattg ccaagtacct      540

ggacaacatc cacctgcacc ccgaggagga gaagtaccgg aagatcaagc tgcagaacaa      600

ggtgtttcag gagcgcatta actgcctgga agggacccac gagttttttg aggccattgg      660

gttccagaag gtgttgcttc ccgcccagga tcaggaggac cccgaggagt tctacgtgct      720

gagcgagacc accttggccc agccccagag cctggagagg cacaaggaac agctgctggc      780

tgcggagccc gtgcgcgcca agctggacag gcagcgccgc gtcttccagc cctcgcccct      840

ggcctcgcag ttcgaactgc ctggggactt cttcaacctc acagcagagg agatcaagcg      900

ggagcagagg ctcaggtccg aggcggtgga gcggctgagc gtgctgcgga ccaaggccat      960

gcgggagaag gaggagcagc gggggctgcg caagtacaac tacacgctgc tgcgcgtgcg     1020

cctccccgat ggctgcctcc tgcagggcac tttctacgct cgggagcggc tgggggcggt     1080

gtacgggttc gtccgggagg ccctgcagag cgactggctg ccttttgagc tgctggcctc     1140

gggagggcag aagctgtccg aggacgagaa cctggccttg aacgagtgcg ggctggtgcc     1200

ctctgccctc ctgaccttct cgtgggacat ggctgtgctg gaggacatca aggccgcggg     1260

ggccgagccg gactccatcc tgaaacccga gctcctgtca gccatcgaga agctcttgtg     1320

aaataaaagc agggttggcc tcagccctgt gggtctgtct catgctctcc ctgttcctct     1380

ccccgccacc ccagggcctc caagccacct ctggaaatac ttggctctgc cccatgggca     1440

cgggaggggc gccagccgtg gagctgtgga attgggcccc gtggcagagc ccccatccct     1500

tgggggctgt ggggatgcgc ccaagccccc gagggagagg cctggggaca ccaacaaatc     1560

taagccctcc ctagctgctt ggtaactgtg tcatgaagct gccggacaga cacacgtggc     1620

atctccctgg gcaggagagc aggcctgcag catgggtccc gttcccgtgt gccgtgggtg     1680

gcagtggctg cacctggcac tagggctgct ctgtggatgt gggtgacaac ggcaggaggg     1740

gacgctggcc ttcctgcaca tagacctgca gttagtaaat cataagccca aataaacagg     1800

ttgtttgaaa aaaaaaaaaa aaaaa                                           1825


<210>  135
<211>  6821
<212>  DNA
<213>  Homo sapiens

<400>  135
aatctcccaa ggcctaagga ggcaagaggc ctgcaaatcg cctcctgctc agcaaacggg       60

ttgctcagca ggcccggggt cctggtccac cccaggtccc tggtttgccc acctccgatg      120

gcggccttcg ctggcagggt gggcgcctct ggggagccag ctccgtcccg gcgcctttag      180

agccccatct cttccacgtc cctggccttc ctccccttcc aggcggctgt ccccgccggg      240

gtccagatgg tgtcggaggg ccggcggttc gacggcgggc ccggggttca gcctcccggc      300

ctccctccgt ccctgactct cctttcttcg gagagggcgc gggggccggg gccaaagcgc      360

cgctcttggg gttctcctgg actcggagtt gccccaggcg ggcgcagctc tgccccgcgg      420

ggtgccagcc tcgggcgggc aaggtccgtg agtcaccgcc tgtaaccgaa caccaggcct      480

ccctgccccc tcccccagct ccggccgcca ggctgcggcg acacctacaa gaaaatgaag      540

gggcgcccag gcccgcggcg gccccggccg tatcgcgagc aggtcccggc ggcccccggc      600

tcgcggcgct ctttcttccc cggccccggg gctcggccag ccgcaaccgc cgccccggcg      660

ccagcaggaa tccaggccga gcgaccggcc ccggagcccg aggcggcgga gggcccgcgg      720

tagctgcgac tggcgagccc gagagcgccc ggggaggggg cgcccggctt ggaatttccc      780

ggtcccttcc ggcccagcga ggacaaagca ctcctggccg ccgccgccgc cgccgccgtg      840

gcctacgccg cgccgcacaa agggcgagtc gcgacacgct cccatccccc tcccagctca      900

cggcggcccc ggccccgggt ggctgcaggg aggtggggga agccctggct gcaccgcccc      960

tcgctccccc tcccctgggg ccgcgcgagc gccgcccccg ccccgtctgc gcgtcctccc     1020

ggggaggggt tggggggcgc ggcgccccac ataacactcc ccctcctgcg ctgcgagcca     1080

ccctctcccc tccctcctgc aaacaccacc gcctcccctg ccaccgccgc cacctcgccc     1140

gacgctccac agctcgccgc ggccgggggg cggtgcgcgg accgtgcgcg ccgcgggcgc     1200

cagatgtgca gtccccgccg ccgccagtga ccgagccgca gtccgagcgg tatcgggccg     1260

cctccctgat gctgcggggg cgaccttgag cgtacagcgg cttccctcgg tggggacccc     1320

gacatcccag cgctgtgccc ggtcttgccc tctgtagccc ggctcgcccc gcgcttggac     1380

atggaagggg ccgccgcgcc tgtggcgggg gaccgccccg acttggggct gggggcgccg     1440

ggctctcccc gagaggcggt ggcgggggcg actgcagccc tggagcccag gaagccgcac     1500

ggggtgaagc ggcatcacca caagcacaac ttgaagcacc gctacgagct gcaggagacc     1560

ctgggcaaag gcacctacgg caaagtcaag cgggccaccg agaggttttc tggccgagtg     1620

gttgctataa aatccattcg taaggacaaa attaaggatg aacaagacat ggttcacatc     1680

agacgagaga ttgagatcat gtcatctctc aaccatcctc atatcatcag tatttatgaa     1740

gtgtttgaga acaaagataa gattgtgatc atcatggaat atgccagcaa aggggagctg     1800

tacgattaca tcagtgagcg gcgacgcctc agtgagaggg agacccggca cttcttccgg     1860

cagatcgtct ctgctgtgca ctattgtcac aagaacggtg tggtccaccg ggacttgaag     1920

ctggaaaata tactgctcga tgacaactgc aatattaaga ttgctgactt tgggctttcc     1980

aacctgtacc agaaggataa gttcttacaa acgttttgtg ggagtccact ctatgcatct     2040

cctgagattg tcaatgggag accttaccga gggccagagg tggacagctg ggccctgggt     2100

gtgttgcttt acactcttgt ttatggaaca atgcccttcg atggtttcga tcacaaaaac     2160

ctcattcggc aaatcagcag cggagagtac cgggagccaa cacagccctc agatgctcga     2220

ggactcatac ggtggatgct gatggtgaac cccgatcgcc gggccactat tgaggacatt     2280

gccaaccact ggtgggtgaa ctggggctat aagagcagcg tgtgtgactg tgatgccctc     2340

catgactctg agtccccact cctggctcgg atcattgact ggcaccaccg ttccacaggg     2400

ctgcaggctg acaccgaagc caaaatgaag ggcctggcca aacccacgac ctctgaggtc     2460

atgctagagc ggcagcggtc gctgaagaaa tccaagaaag agaatgactt tgctcagtct     2520

ggtcaggatg cagtgcctga aagcccatcc aagttgagtt ctaagaggcc caaggggatc     2580

ctgaagaagc gaagcaacag cgagcatcgc tctcacagca ctggcttcat tgaaggtgta     2640

gttggtcctg ccttaccctc tactttcaag atggagcagg acttgtgcag gactggcgtg     2700

ctcctcccaa gctcaccaga ggcagaggtg ccgggaaaac tcagccccaa gcagtcggcc     2760

acgatgccca agaaaggcat cttgaaaaag acccagcaga gagaatcagg ttactactct     2820

tccccagagc gcagtgagtc ttcggagctg ttggacagta atgatgtgat gggcagcagc     2880

atcccctccc ccagcccccc ggacccagcc agggtaacct cccacagcct ctcctgccgg     2940

aggaagggca tcttgaaaca cagcagcaaa tactcagcgg gcaccatgga cccagccctg     3000

gtcagccctg aaatgcccac actggaatcc ctgtcagagc ctggtgtccc tgccgagggc     3060

ctctcccgga gctacagccg cccttccagt gtcatcagcg atgacagcgt gctgtccagc     3120

gactcttttg acttgctgga tttgcaggag aatcgccctg cccgccagcg catccgcagc     3180

tgcgtctctg cagaaaactt cctccagatc caggactttg aggggctcca gaaccggccc     3240

cggccccagt acctgaagcg gtaccggaac cggctggcag acagcagctt ctccctcctc     3300

acagacatgg atgatgtgac tcaggtctac aagcaagcgc tggagatctg cagcaagctc     3360

aactagcatt ccagggcgcc caggggcggg cgggggtacg agggaggaag gggagcaaga     3420

cttgggctca caggctggtt acctctttgc tggctgtgac aacagactga aaaaggattg     3480

gcactgtctc acttggccaa gtttgcagcc ttgagccaac acctaaaagg gagaggtggg     3540

ctcttctgcc agttctgtca attgtcagtc agaatttggg ccctgtttgg catttgcttt     3600

atggcacctc ctagaggacc agctgtccag gggaggtggt attgaccggc actcagtggg     3660

tggagaggaa gcatatgtgg aaggagcatt tccttagaag tcatccagat gcttctggag     3720

gaggggcagg agacacttgg gctgtttgcc ttgggtgagc ccaaagaact tgcccctttt     3780

ctccttgtat tagcaagcta ggtctggctg cgtggagctg gcaagtagat ttcagcaact     3840

tgagcttgag ttgacgatca attaatagtg gctgccagtt gtgctggcgt aagtggccca     3900

catcatgggg aaggagtgct gtgattgact agtaatggct accacgggaa agggaagggg     3960

aagcagtagc actaatgcta tgtagttgtc atctttgatc tggctaggcc ctgggaatcg     4020

ggtttagtca tcctgtggga tctatgttaa ctctttcatg ccactggtga ggcatttgtt     4080

aatttgctac tcaactttga ggaaagacag ggccttggtc agagagagaa tgctctgaac     4140

tctgctaagg acatagagtc agcccatggt gatttagctc cttgctgttc acctcctctt     4200

tcctgatgtc tgccttgctc tacagcacaa cctcttgagg gtggacaggg agaaagatga     4260

tggtgtcaga ggtcaaaact attatatatg acagggcaca agatggtctg tgatctttgc     4320

acagatgaat ggaagttgat gcacaccaac aagaggcaac ttgtcacttt ctttctcaat     4380

attaactgga atgctgcctc ttgggttctc acctgcatgg atgctttgag ttggacgtga     4440

tactgtccat attctccaga ggattacctg gctgaaccat tggctctgtt caccagtgac     4500

agatggtttc cccatccact gagtgtagca tcctcagagg taggcaagtt tgcttctagg     4560

gagttagcat gtagatggga tattgggatg aggaaaggaa aatcaggtag atggtgcttt     4620

ttttccccca aatctaagta ttctatgtca tggttttaaa ctttgccatg aactcctggg     4680

ctttggggga agagaaagtt ccattcattt aaatgaataa ggtgttgaaa gagtgcaggg     4740

ggttgggagg aagcatgtaa gagagggaac atttccttag atgttaccca gatggttctg     4800

ggggagacag aaaagaggtg cggcaggact cttatcttaa aaagtaaaca aaacaaaaca     4860

aaacaaaaca aaaaactaga tatgtaattt ctaaacaccc agatcacaat gacaagatgc     4920

cactccaacc atgggacacc ttcatgatac taggtttgta cttcctggtc tctgggatga     4980

cttcagattc tgctggccaa ggcaaattga actcagttca agatggccac cactggtaga     5040

cgtgtagata gaaaagagga ctggtcttgg gaacatcttt ggaaaaacca acaaacaata     5100

gttctaggga gatgagaaaa aaattcacct tacagtgcta agaaagtgca ttagaatgga     5160

attgcccttt ccttaaggag acagtttggg ctctcccctt gccaccggct ctggtgtttt     5220

ggcttatgcg ttccttcagg ttgagctgag cagtgtgtta tgggaagctg ctcaatttcc     5280

tttcattcaa ttccacctcc ttcctgaact ctaatagagg ttaaaaggga aaaaaaaaat     5340

tctgtagata gcaaattgtg tgtgtggggg ggggtggggg tgtgggtgca tggaggacaa     5400

cctgcaactc tgagctccct acttcctgcc tcatttcatg cagtcttttc tgaacagcct     5460

atgctgctgc cctgctggcc ccttgtgcac ggcagctggc cgtgtccgta gctgtcagta     5520

tgacttagat ctagctccta cctactggtt gatgtgtttt ttccttttgc caagtgattg     5580

agtctgttta gtagtttcca tcattctagt ctttaagtaa aaatgacact attgaggaaa     5640

gtcagtctac tcccttcttc ctccccccaa acacgtgttc tcttttgtca ggaaactcag     5700

ccagtggact gtggcagaga aagtcctcca ctcagaggca gagactgagt taagtcatag     5760

gtggccttag gcatctgcat tgtttgcagg ggttaagttt tccttccagt gagggctgga     5820

gggatgaatt agctggtacc tgaagccccg cttagctctg acactctgcc aacatcctct     5880

gattctaggt gtggtgttga ctgtcctttc aaggaaaaac ttgcaataga gggaaaagcc     5940

attaaagcag ctccctgctt catcattaag tcctgtcatc cctaccagcc aatcccagtc     6000

aaagaagtta tgctttattc acttctgtgg aattacaagt gagagacact tttaggacct     6060

gatggacaaa gcaggagatt cactgtcagc tttcctggtc ctctccttac ttctgtgggc     6120

cttgcaccgt cttagtttac acatctgcca aaggggtaga attacacttc tttttacagg     6180

taaatgtcaa ggcacaatca gttttcagga agtgcttcaa gaccccaggt gaaatgaaaa     6240

tgctaagtac cctctgaatg gccatgcctg ttaccaggtg ctgcttcttc agatgatggg     6300

gagcactttt cagggtgaaa ttcaggcgag ttttgcccag gcctgctgtc ttgagtacaa     6360

atgtgaatga tcgactgact gcttgttgcc aaactggaaa tgttctgtag ggatttactg     6420

gcatggtatc attcctagaa gaaaaaaaga gagaaacttg actgcacatt aaaaaaaaaa     6480

aaaaatccac attgtgactt ttatttaatt tctatttttt ttggtaataa aaagttgact     6540

tttttatttg aatttgtctt ttttatttat tggtctgaaa ggcatttcaa aggtattata     6600

ataatatatt ggtgtaattt aattggtgca acatgcttta tggctcctgt caaaattggt     6660

tttcactcat ttgattggtt tgagcccaga acagcctaca ggggaaaaac aagctggata     6720

accacccaaa gtgtttgtat tttcgttgga aactgatttt tgtttcattt tggtttttgt     6780

ttctgttttt atttttaaat taaataaatt gcaatgaact g                         6821


<210>  136
<211>  1745
<212>  DNA
<213>  Homo sapiens

<400>  136
tccagaaggt accttgggtc tcactgtgtc atccagagct ggagtgcagc ggcacagtca       60

tggctcactg gaactcaggc tcaagcaatc ctcccgcctc agccttccaa gtaactagga      120

ctacaggtgt ctgagatgct gccaccgcag aagaagccct gggagtccat ggctaagggg      180

ctggtgctgg gcgcgctctt cactagtttc ctgctgctga tgtactccta tgccgtgccc      240

ccgctgcatg ccggcctggc ctccacgacc ccggaggccg cagcgtcctg ctctccacct      300

gcactcgagc cagaggcagt gatccgggcc aacggctcgg cgggggagtg ccagccgcgg      360

cgcaacatcg tgttcttgaa gacgcacaag acggccagca gcaccctgct caacatcctg      420

ttccgcttcg gccagaagca ccggctcaag ttcgccttcc ctaacggccg caatgacttc      480

gactacccga ccttcttcgc ccgcagcctg gtgcaggact atcggcccgg ggcctgcttc      540

aacatcatct gcaaccacat gcgcttccac tacgacgagg tgcgcggcct ggtgccgacc      600

aacgccatct tcatcacggt gctccgcgac cccgcccgct tgttcgagtc ctccttccac      660

tacttcgggc cggtggtgcc cctcacgtgg aagctctcgg ccggcgacaa gctgaccgag      720

ttcctgcaag acccggatcg ctactacgac cccaacggct tcaatgccca ctacctccga      780

aacctgctct tcttcgacct gggctatgac aacagcctgg accccagcag cccgcaggtg      840

caggagcaca tcctggaggt ggagcgtcgc ttccacctgg tgctccttca agagtacttc      900

gacgagtcgc tggtgctgct gaaggacctg ctgtgctggg agctggagga cgtgctctac      960

ttcaagctca acgcccgccg cgactcgccc gtgccgcggc tctcggggga gctgtatggg     1020

cgcgccaccg cctggaacat gctggactcc cacctctacc gccacttcaa cgccagcttc     1080

tggcgcaagg tggaggcctt cgggcgggag cgcatggccc gcgaggtggc cgccctgcgc     1140

catgccaacg agcgcatgcg gaccatctgc atcgacgggg gccacgccgt ggacgccgcc     1200

gccatccagg acgaggccat gcagccctgg cagccgctgg gcaccaagtc catcctgggc     1260

tacaacctca agaagagcat cgggcagcgg cacgcgcagc tctgccggcg catgctcacg     1320

cccgagatcc agtacctgat ggacctcggc gccaacctgt gggtcaccaa gctctggaag     1380

ttcattcgcg atttcctgcg gtggtgacgt cccaccgccc agcggcttgc ctgcctgctc     1440

gctccctgca gaggggctga gcaggacgcc gctggtgctg gccgccccca gccccctcct     1500

ggtgccacct cagaccccgg ggtgaggggg ggctccctgg ggggaggcag ccagccaaga     1560

ctgggcccat gaacacagag agggcctaac cgagatcagt atttaactaa ttataccagt     1620

ttttattaaa cccctttccc tccccgataa agaatgttct atttctgcct ccccttaaag     1680

gggagacctc agaagtaaag gaatttgatg ttgaaaaaaa aaaaaaaaaa aaaaaaaaaa     1740

aaaaa                                                                 1745


<210>  137
<211>  1157
<212>  DNA
<213>  Homo sapiens

<400>  137
gtcagcagag gcctcgctcg ggcgcccagt ggtcctgccg cctggtctca cctcgctatg       60

gttcgtctgc ctctgcagtg cgtcctctgg ggctgcttgc tgaccgctgt ccatccagaa      120

ccacccactg catgcagaga aaaacagtac ctaataaaca gtcagtgctg ttctttgtgc      180

cagccaggac agaaactggt gagtgactgc acagagttca ctgaaacgga atgccttcct      240

tgcggtgaaa gcgaattcct agacacctgg aacagagaga cacactgcca ccagcacaaa      300

tactgcgacc ccaacctagg gcttcgggtc cagcagaagg gcacctcaga aacagacacc      360

atctgcacct gtgaagaagg ctggcactgt acgagtgagg cctgtgagag ctgtgtcctg      420

caccgctcat gctcgcccgg ctttggggtc aagcagattg ctacaggggt ttctgatacc      480

atctgcgagc cctgcccagt cggcttcttc tccaatgtgt catctgcttt cgaaaaatgt      540

cacccttgga caagctgtga gaccaaagac ctggttgtgc aacaggcagg cacaaacaag      600

actgatgttg tctgtggtcc ccaggatcgg ctgagagccc tggtggtgat ccccatcatc      660

ttcgggatcc tgtttgccat cctcttggtg ctggtcttta tcaaaaaggt ggccaagaag      720

ccaaccaata aggcccccca ccccaagcag gaaccccagg agatcaattt tcccgacgat      780

cttcctggct ccaacactgc tgctccagtg caggagactt tacatggatg ccaaccggtc      840

acccaggagg atggcaaaga gagtcgcatc tcagtgcagg agagacagtg aggctgcacc      900

cacccaggag tgtggccacg tgggcaaaca ggcagttggc cagagagcct ggtgctgctg      960

ctgctgtggc gtgagggtga ggggctggca ctgactgggc atagctcccc gcttctgcct     1020

gcacccctgc agtttgagac aggagacctg gcactggatg cagaaacagt tcaccttgaa     1080

gaacctctca cttcaccctg gagcccatcc agtctcccaa cttgtattaa agacagaggc     1140

agaaaaaaaa aaaaaaa                                                    1157


<210>  138
<211>  872
<212>  DNA
<213>  Homo sapiens

<400>  138
gagattggaa acagccaggt tggagcagtg agtgagtaag gaaacctggc tgccctctcc       60

agattcccca ggctctcaga gaagatcagc agaaagtctg caagacccta agaaccatca      120

gccctcagct gcacctcctc ccctccaagg atgacaaagg cgctactcat ctatttggtc      180

agcagctttc ttgccctaaa tcaggccagc ctcatcagtc gctgtgactt ggcccaggtg      240

ctgcagctgg aggacttgga tgggtttgag ggttactccc tgagtgactg gctgtgcctg      300

gcttttgtgg aaagcaagtt caacatatca aagataaatg aaaatgcaga tggaagcttt      360

gactatggcc tcttccagat caacagccac tactggtgca acgattataa gagttactcg      420

gaaaaccttt gccacgtaga ctgtcaagat ctgctgaatc ccaaccttct tgcaggcatc      480

cactgcgcaa aaaggattgt gtccggagca cgggggatga acaactgggt agaatggagg      540

ttgcactgtt caggccggcc actcttctac tggctgacag gatgccgcct gagatgaaac      600

agggtgcggg tgcaccgtgg agtcattcca agactcctgt cctcactcag ggattcttca      660

tttcttcttc ctactgcctc cacttcatgt tattttcttc ccttcccatt tacaactaaa      720

actgaccaga gccccaggaa taaatggttt tcttggcttc ctccttactc ccatctggac      780

ccagtcccct ggttcctgtc tgttatttgt aaactgagga ccacaataaa gaaatcttta      840

tatttatcga aatattaaag cactcgctct gc                                    872


<210>  139
<211>  1322
<212>  DNA
<213>  Homo sapiens

<400>  139
gcggactccg cggacaaggc caggcctagc cttgagctcc gtcgggcagg gccgccggga       60

ttggtgtccg gcagagcgtg agcccagcgg gctggagtcg gcgagcggga gtgaaagaag      120

aaaagctaga gagcgaaggc aaagcccgag gagagagggc cacggtcggc ggaggaatct      180

gactgcacgg ttgcgtgcgc tcactgccgg agggctccct cagccgggcg gctccgctag      240

tggctaaagg caaagcattc cggggcgcgg cgcatgaagt tgagcttcgt ccctgctagc      300

cgccgctttc tccccaaaaa tacatcctag ccttaatgtt tatgcctcca ttgccccagt      360

tcttatctgt tttgctcaat gtctcatagc tacaagaagg caatttctga cgaagccctc      420

cgtcccttcc aaatggatta ttttggcggg cttccacccg gacagtatgc cacccgaatg      480

actggacaag tgcacgggag cggctgtcat ttgcggagtg cgccttgcga tctaggcgcc      540

tcacagcgca aattatccag taatttctct gaaatcgatg ctggtttgtt ttcccaaggc      600

aaatcagcag cttatacaga cattggggcc acaaagccgg tggaacaacg ggagacggct      660

tcctgagtgt caggtcctcc aagatgagct taaacttcgg gtggtgggca ggctcggtag      720

gcgggaaagg cccgtgtcca gatgaatgca gtccatgttt atattgatga aagacacgta      780

taccatttgg tccagctcaa ccattcttaa caagtgctgg ctgtgagcac tggtgtgtgt      840

gtgcctgcgt gcaaccagca atgtaagtga tgaccagctg catgatgcct taatttgagt      900

ggacaaagtc ggtcaagaac cactttcagg cttctgggtc tccaagtctt tgtctccctg      960

tatccaaacg aggcattcca agtttgacag catggaacat tgcatgtccg aaataccaac     1020

cgtgaaactg ggtaaaaagc ttcaggaggt gatattgatg tgtatagttt aggaaataaa     1080

acccaatact tacttcaaag aacgtaattt gtggcttttt agagagaagg atactttgac     1140

agttttcatt tgtcgtctac atgtatatgg tacgtttcat tctgcctttt aattaatttg     1200

gtattttact atgaaaacta ctttgtatta ataaaataat gtatttccaa tgttataagt     1260

tgtgttataa cagtttcaaa agccaaataa acaagatgca ttttgaaaaa aaaaaaaaaa     1320

aa                                                                    1322


<210>  140
<211>  3599
<212>  DNA
<213>  Homo sapiens

<400>  140
gcccgttgtc tgtgtgtggg actgaggggc cccgggggcg gtgggggctc ccggtggggg       60

cagcggtggg gagggagggc ctggacatgg cgctgagggg ccgccccgcg ggaagatgaa      120

taagggctgg ctggagctgg agagcgaccc aggcctcttc accctgctcg tggaagattt      180

cggtgtcaag ggggtgcaag tggaggagat ctacgacctt cagagcaaat gtcagggccc      240

tgtatatgga tttatcttcc tgttcaaatg gatcgaagag cgccggtccc ggcgaaaggt      300

ctctaccttg gtggatgata cgtccgtgat tgatgatgat attgtgaata acatgttctt      360

tgcccaccag ctgataccca actcttgtgc aactcatgcc ttgctgagcg tgctcctgaa      420

ctgcagcagc gtggacctgg gacccaccct gagtcgcatg aaggacttca ccaagggttt      480

cagccctgag agcaaaggat atgcgattgg caatgccccg gagttggcca aggcccataa      540

tagccatgcc aggcccgagc cacgccacct ccctgagaag cagaatggcc ttagtgcagt      600

gcggaccatg gaggcgttcc actttgtcag ctatgtgcct atcacaggcc ggctctttga      660

gctggatggg ctgaaggtct accccattga ccatgggccc tggggggagg acgaggagtg      720

gacagacaag gcccggcggg tcatcatgga gcgtatcggc ctcgccactg caggggagcc      780

ctaccacgac atccgcttca acctgatggc agtggtgccc gaccgcagga tcaagtatga      840

ggccaggctg catgtgctga aggtgaaccg tcagacagta ctagaggctc tgcagcagct      900

gataagagta acacagccag agctgattca gacccacaag tctcaagagt cacagctgcc      960

tgaggagtcc aagtcagcca gcaacaagtc cccgctggtg ctggaagcaa acagggcccc     1020

tgcagcctct gagggcaacc acacagatgg tgcagaggag gcggctggtt catgcgcaca     1080

agccccatcc cacagccctc ccaacaaacc caagctagtg gtgaagcctc caggcagcag     1140

cctcaatggg gttcacccca accccactcc cattgtccag cggctgccgg cctttctaga     1200

caatcacaat tatgccaagt cccccatgca ggaggaagaa gacctggcgg caggtgtggg     1260

ccgcagccga gttccagtcc gcccacccca gcagtactca gatgatgagg atgactatga     1320

ggatgacgag gaggatgacg tgcagaacac caactctgcc cttaggtata aggggaaggg     1380

aacagggaag ccaggggcat tgagcggttc tgctgatggg caactgtcag tgctgcagcc     1440

caacaccatc aacgtcttgg ctgagaagct caaagagtcc cagaaggacc tctcaattcc     1500

tctgtccatc aagactagca gcggggctgg gagtccggct gtggcagtgc ccacacactc     1560

gcagccctca cccaccccca gcaatgagag tacagacacg gcctctgaga tcggcagtgc     1620

tttcaactcg ccactgcgct cgcctatccg ctcagccaac ccgacgcggc cctccagccc     1680

tgtcacctcc cacatctcca aggtgctttt tggagaggat gacagcctgc tgcgtgttga     1740

ctgcatacgc tacaaccgtg ctgtccgtga tctgggtcct gtcatcagca caggcctgct     1800

gcacctggct gaggatgggg tgctgagtcc cctggcgctg acagagggtg ggaagggttc     1860

ctcgccctcc atcagaccaa tccaaggcag ccaggggtcc agcagcccag tggagaagga     1920

ggtcgtggaa gccacggaca gcagagagaa gacggggatg gtgaggcctg gcgagccctt     1980

gagtggggag aaatactcac ccaaggagct gctggcactg ctgaagtgtg tggaggctga     2040

gattgcaaac tatgaggcgt gcctcaagga ggaggtagag aagaggaaga agttcaagat     2100

tgatgaccag agaaggaccc acaactacga tgagttcatc tgcaccttta tctccatgct     2160

ggctcaggaa ggcatgctgg ccaacctagt ggagcagaac atctccgtgc ggcggcgcca     2220

aggggtcagc atcggccggc tccacaagca gcggaagcct gaccggcgga aacgctctcg     2280

cccctacaag gccaagcgcc agtgaggact gctggccctg actctgcagc ccactcttgc     2340

cgtgtggccc tcaccagggt ccttccctgc cccacttccc cttttcccag tattactgaa     2400

tagtcccagc tggagagtcc aggccctggg aatgggagga accaggccac attccttcca     2460

tcgtgccctg aggcctgaca cggcagatca gccccatagt gctcaggagg cagcatctgg     2520

agttggggca cagcgaggta ctgcagcttc ctccacagcc ggctgtggag cagcaggacc     2580

tggcccttct gcctgggcag cagaatatat attttaccta tcagagacat ctatttttct     2640

gggctccaac ccaacatgcc accatgttga cataagttcc tacctgacta tgctttctct     2700

cctaggagct gtcctggtgg gcccaggtcc ttgtatcatg ccacggtccc aactacaggg     2760

tcctagctgg gggcctgggt gggccctggg ctctgggccc tgctgctcta gccccagcca     2820

ccagcctgtc cctgttgtaa ggaagccagg tcttctctct tcattcctct taggagagtg     2880

ccaaactcag ggacccagca ctgggctggg ttgggagtag ggtgtcccag tggggttggg     2940

gtgagcaggc tgctgggatc ccatggcctg agcagagcat gtgggaactg ttcagtggcc     3000

tgtgaactgt cttccttgtt ctagccaggc tgttcaagac tgctctccat agcaaggttc     3060

tagggctctt cgccttcagt gttgtggccc tagctatggg cctaaattgg gctctaggtc     3120

tctgtccctg gcgcttgagg ctcagaagag cctctgtcca gcccctcagt attaccatgt     3180

ctccctctca ggggtagcag agacagggtt gcttatagga agctggcacc actcagctct     3240

tcctgctact ccagtttcct cagcctctgc aaggcactca gggtggggga cagcaggatc     3300

aagacaaccc gttggagccc ctgtgttcca gaggacctga tgccaagggg taatgggccc     3360

agcagtgcct ctggagccca ggccccaaca cagccccatg gcctctgcca gatggctttg     3420

aaaaaggtga tccaagcagg cccctttatc tgtacatagt gactgagtgg ggggtgctgg     3480

caagtgtggc agctgcctct gggctgagca cagcttgacc cctctagccc ctgtaaatac     3540

tggatcaatg aatgaataaa actctcctaa gaatctcctg agaaaaaaaa aaaaaaaaa      3599


<210>  141
<211>  4793
<212>  DNA
<213>  Homo sapiens

<400>  141
attggatcaa acatgtcaca agagtcggac aataataaaa gactagtggc cttagtgccc       60

atgcccagtg accctccatt caatacccga agagcctaca ccagtgagga tgaagcctgg      120

aagtcatact tggagaatcc cctgacagca gccaccaagg ccatgatgat cattaatggt      180

gatgaggaca gtgctgctgc cctcggcctg ctctatgact actacaaggt tcctcgagac      240

aagaggctgc tgtctgtaag caaagcaagt gacagccaag aagaccagga gaaaagaaac      300

tgccttggca ccagtgaagc ccagagtaat ttgagtggag gagaaaaccg agtgcaagtc      360

ctaaagactg ttccagtgaa cctttcccta aatcaagatc acctggagaa ttccaagcgg      420

gaacagtaca gcatcagctt ccccgagagc tctgccatca tcccggtgtc gggaatcacg      480

gtggtgaaag ctgaagattt cacaccagtt ttcatggccc cacctgtgca ctatccccgg      540

ggagatgggg aagagcaacg agtggttatc tttgaacaga ctcagtatga cgtgccctcg      600

ctggccaccc acagcgccta tctcaaagac gaccagcgca gcactccgga cagcacatac      660

agcgagagct tcaaggacgc agccacagag aaatttcgga gtgcttcagt tggggctgag      720

gagtacatgt atgatcagac atcaagtggc acatttcagt acaccctgga agccaccaaa      780

tctctccgtc agaagcaggg ggagggcccc atgacctacc tcaacaaagg acagttctat      840

gccataacac tcagcgagac cggagacaac aaatgcttcc gacaccccat cagcaaagtc      900

aggagtgtgg tgatggtggt cttcagtgaa gacaaaaaca gagatgaaca gctcaaatac      960

tggaaatact ggcactctcg gcagcatacg gcgaagcaga gggtccttga cattgccgat     1020

tacaaggaga gctttaatac gattggaaac attgaagaga ttgcatataa tgctgtttcc     1080

tttacctggg acgtgaatga agaggcgaag attttcatca ccgtgaattg cttgagcaca     1140

gatttctcct cccaaaaagg ggtgaaagga cttcctttga tgattcagat tgacacatac     1200

agttataaca atcgtagcaa taaacccatt catagagctt attgccagat caaggtcttc     1260

tgtgacaaag gagcagaaag aaaaatccga gatgaagagc agaagcagaa caggaagaac     1320

gggaaaggcc aggcctccca aactcaatgc aacagctcct ctgatgggaa gttggctgcc     1380

atacctttac agaagaagag tgacatcacc tacttcaaaa ccatgcctga tctccactca     1440

cagccagttc tcttcatacc tgatgttcac tttgcaaacc tgcagaggac cggacaggtg     1500

tattacaaca cggatgatga acgagaaggt ggcagtgtcc ttgttaaacg gatgttccgg     1560

cccatggaag aggagtttgg tccggtgcct tcaaagcaga tgaaagaaga agggacaaag     1620

cgagtgctct tgtacgtgag gaaggagact gacgatgtgt tcgatgcatt gatgttgaag     1680

tctcccacag tgatgggcct gatggaagcg atatctgaga aatatgggct gcccgtggag     1740

aagatagcaa agctttacaa gaaaagcaaa aaaggcatct tggtgaacat ggatgacaac     1800

atcatcgagc actactcgaa cgaggacacc ttcatcctca acatggagag catggtggag     1860

ggcttcaagg tcacgctcat ggaaatctag ccctgggttt ggcatccgct ttggctggag     1920

ctctcagtgc gttcctccct gagagagaca gaagccccag ccccagaacc tggagaccca     1980

tctcccccat ctcacaactg ctgttacaag accgtgctgg ggagtggggc aagggacagg     2040

ccccacagtc ggtgtgcttg gcccatccac tggcacctac cacggagccg aagcctgagc     2100

ccctcaggaa ggtgccttag gcctgttgga ttcctattta ttgcccacct tttcctggag     2160

cccaggtcca ggcccgccag gactctgcag gtcactgcta gctccagatg agaccgtcca     2220

gcgttccccc ttcaagagaa acactcatcc cgaacagcct aaaaaattcc catcccttct     2280

ttctcacccc tccatatcta tatctcccga gtggctggac aaaatgagct acgtctgggt     2340

gcagtagtta taggtggggc aagaggtgga tgcccacttt ctggtcagac acctttaggt     2400

tgctctgggg aaggctgtct tgctaaatac ctccagggtt cccagcaagt ggccaccagg     2460

ccttgtacag gaagacattc agtcaccgtg taattagtaa cacagaaagt ctgcctgtct     2520

gcattgtaca tagtgtttat aatattgtaa taatatattt tacctgtggt atgtgggcat     2580

gtttactgcc actggcctag aggagacaca gacctggaga ccgttttaat gggggttttt     2640

gcctctgtgc ctgttcaaga gacttgcagg gctaggtaga gggcctttgg gatgttaagg     2700

tgactgcagc tgatgccaag atggactctg caatgggcat acctgggggc tcgttccctg     2760

tccccagagg aagccccctc tccttctcca tgggcatgac tctccttcga ggccaccacg     2820

tttatctcac aatgatgtgt tttgcctgac tttccctttg cgctgtctcg tgggaaaggt     2880

cattctgtct gagaccccag ctccttctcc agctttggct gcgggcatgg cctgagcttt     2940

ctggagagcc tctgcagggg gtttgccatc agggccctgt ggctgggtct gctgcagagc     3000

tccttggcta tcaggagaat cctggacact gtactgtgcc tcccagttta caaacacgcc     3060

cttcatctca agtggccctt taaaaggcct gctgccatgt gagagctgtg aacagctcag     3120

ctctgagtcg gcagactggg gcttcctcct gggccaccag atggaaaggg ggtattgttt     3180

gcctcactcc tggatgctgc gttttaagga agtgagtgag aaagaatgtg ccaagatacc     3240

tggctcctgt gaaaccagcc tcaggaggga aactgggaga gagaagctgt ggtctcctgc     3300

tacatgccct gggagctgga agagaaaaac actcccctaa acaatcgcaa aatgatgaac     3360

catcatgggc cactgttctc tttgagggga caggtttagg ggtttgcgtt cgcccttgtg     3420

ggctgaagca ctagcttttt ggtagctaga cacatcctgc acccaaaggt tctctacaaa     3480

ggcccagatt tgtttgtaaa gcactttgac tcttacctgg aggcccgctc tctaagggct     3540

tcctgcgctc ccacctcatc tgtccctgag atgcagagca ggatggaggg tctgcttcta     3600

gctcagctgt ttctccttga ggttgcggag gaattgaatt gaatgggaca gagggcaggt     3660

gctgtggcca agaagatctc cgagcagcag tgacggggca ccttgctgtg tgtcctctgg     3720

gcatgttaac ccttctgtgg ggccaaaggt ttgcatcgtg gatccagctg tgctccagtc     3780

tgtcccctcc tcctccactc tgactgccac gccccggacc agcagcttgg ggaccctcca     3840

gggtactaat ggggctctgt tctgagatgg acaaattcag tgttggaaat acatgttgta     3900

ctatgcactt cccatgctcc tagggttagg aatagtttca aacatgattg gcagacataa     3960

caacggcaaa tactcggact ggggcatagg actccagagt aggaaaaaga caaaagattt     4020

ggcagcctga cacaggcaac ctacccctct ctctccagcc tctttatgaa actgtttgtt     4080

tgccagtcct gccctaaggc agaagatgaa ttgaagatgc tgtgcatgtt tcctaagtcc     4140

ttgagcaatc atggtggtga caattgccac aagggatatg aggccagtgc caccagaggg     4200

tggtgccaag tgccacatcc cttccgatcc attcccctct gtatcctcgg agcaccccag     4260

tttgcctttg atgtgtccgc tgtgtatgtt agctgaactt tgatgagcaa aatttcctga     4320

gcgaaacact ccaaagagat aggaaaactt gccgcctctt cttttttgtc ccttaatcaa     4380

actcaaataa gcttaaaaaa aatccatgga agatcatgga catgtgaaat gagcattttt     4440

ttcttttctt tttttttttt tttttttaac aaagtctgaa ctgaacagaa caagactttt     4500

tcctcataca tctccaaatt gtttaaactt actttatgag tgtttgttta gaagttcgga     4560

ccaacagaaa aatgcagtca gatgtcatct tggaattggt ttctaaaaga gtaaggcatg     4620

tccctgccca gaaacttagg aagcatgaaa taaatcaaat gtttattttc cttcttattt     4680

aaaatcatgc taatgcaaca gaaatagagg gtttgtgcca aatgctatga acggcccttt     4740

cttaaagaca agcaagggag attgatatat gtacaatttg ctctcatgtt ttt            4793


<210>  142
<211>  1208
<212>  DNA
<213>  Homo sapiens

<400>  142
atggcggcca ccatgaagaa ggcggctgca gaagatgtca atgttacttt cgaagatcaa       60

caaaagataa acaaatttgc acggaataca agtagaatca cagagctgaa ggaagaaata      120

gaagtaaaaa agaaacaact ccaaaaccta gaagatgctt gtgatgacat catgcttgca      180

gatgatgatt gcttaatgat accttatcaa attggtgatg tcttcattag ccattctcaa      240

gaagaaacgc aagaaatgtt agaagaagca aagaaaaatt tgcaagaaga aattgacgcc      300

ttagaatcca gagtggaatc aattcagcga gtgttagcag atttgaaagt tcagttgtat      360

gcaaaattcg ggagcaacat aaaccttgaa gctgatgaaa gttaaacatt ttataatact      420

ttttttattt gtttaataaa cttgaatatt gtttaaaatg ataattttcc ttcttcaaat      480

gacatggaaa gcaaaacttt cttttttaaa aattttcatt tatttaatgg aaacttgccc      540

attttcacat gtctgcttat ttattttata tttttaaaag aagacagtat tcacctatgt      600

attttgcata acgattatat caagtctagg ggcttcatgt catgttatta aaatcagtta      660

agcaatcttt tatgtttcta tattatttag aatatttgtt gttgcaattt tcacataaga      720

aaatttaaca gttgtgtcat gttgtttctg tctgatttta attgctgtct aatgacgggg      780

aaagcacgat gaaaagatgt acaatcctgc atccttgctt atttcacaac taaagctttg      840

tcatagactt caaaatatat atgtatatat tttatttaaa tatatgttac atattatatt      900

taaacataca tatttaacat tttttacata tctatcaata tcagagattt gggtaaaaga      960

atgggtaatg tttaaacatg tggaggcatg tggagcttta tacaaacagg gcagaaccac     1020

agaagaacgt tttagaaacc aagagatgtg cagaaagaaa tgtttagtgt tttttcgttt     1080

taaattttag attttatttt agtgctttgt aattaattgg ggtttatatt gataaagatg     1140

tggaagttaa acagctatgt atgtaaaagt aaggcttatt tcttaaataa aggatgcatt     1200

tcttccca                                                              1208


<210>  143
<211>  2654
<212>  DNA
<213>  Homo sapiens

<400>  143
agctgccgcg ccggggcctg agctgccgcc tcctccgccg cccgaaaacc cggagtgccc       60

cgcacaggtt tagacccagt gtgcctggtg ggctgtgccc aggttcagag tcatgccact      120

ctgtgggtga agcttgaggc aaaaatggag ccacttcagc agcagcagca gcagcagcag      180

caacaacaga agcagccaca cctggctcct ctgcagatgg atgccagaga gaagcagggc      240

cagcagatga gagaagccca gttcttgtat gcccaaaagc tggtcacaca gccgactctc      300

ctttccgcca cagctgggag accttctggc agcactccct taggtccctt agccagagtt      360

ccacccaccg cagcagtggc ccaagtgttt gaacggggca acatgaactc agagcctgag      420

gaagaggacg gaggtttgga agatgaggat ggggatgatg aagttgcaga ggtggctgag      480

aaagaaaccc aggctgcttc aaaatatttt catgtgcaga aagtagctcg ccaagatccc      540

agagtggcac ccatgtccaa tctacttcca gcaccagggc tcccaccaca tggacaacaa      600

gctaaagaag accataccaa agatgcttcc aaggcctcac cttctgtctc cacagcagga      660

cagccgaact ggaatctgga tgagcagctc aagcagaatg gtggtttggc ctggagtgat      720

gatgcagatg gaggccgggg aagagagatc tctcgagatt ttgccaagct gtatgaactg      780

gacggtgatc ctgaaaggaa agagttcctg gatgacctct tcgtctttat gcagaagagg      840

ggtgagtgtg catctactca tcattccaat tcagggaata ctgatagagt gcctactgtg      900

tgctagtcac tgttagacat cctggcccac taatcctcat ccaggaggag aagaggcatt      960

tactgccagt tggttctgga tttagccaat taaccgatag ccagattgaa gaggacagag     1020

aaggtgttgg cacaaagtag atggaatgat cgtccacttt tggccctgcc tgattttgtc     1080

tcttcttcca attgactggt ctctggagtc acttcaaatt caaatatgcc ttttttaagc     1140

cttaaagcta ccctggactt cacttaatct agcatgtggg ccttcttgtt ggcatatcta     1200

gtctcatgga gaaaggtaag tgaaagaaaa gaggcccctc aggatatttt ggaagggtct     1260

gaaatgatcc atggaaagaa aaggccaaca ctttcttctt acccattggc tttcgatgtt     1320

tgtatttgct ggcttggtta gaacattcct gcagtttaat agtcaggtac ataggcatct     1380

gccttttttt ttttttgaga tggagtctcg ctctgttgcc caggctggag tgccatggtg     1440

tgatctcagc tcactgcaac ctctgcctcc cgtgttcagg caattctcat gcctcagcct     1500

cccaagtagc tgggactaca ggcgcgtacc accacacctg gctaattttt gtatttcttt     1560

tttcagtaga gttggggttt caccatgttg gccaggctgg tctcaaaatc cagacctcaa     1620

gtgatccacc tgccttgacc tcccaaagta ctgggattac aggcatgagc caccgcgccc     1680

agccggcatc tgctttataa tgcaccctcc caattctctt tccttctctc ctcactctgc     1740

acatccccaa gagccatctt cactgtagac tatggtgtga ctgagtttag agctgagtga     1800

ctcaacttcc tggctttgta ttcagtcata gcaatgggtt caccagccag gtcagccctc     1860

agaacacatg gccagcaccc cagcctctct aggagaaggc cttcagcaac ctgtgtggct     1920

ccaccttcgt caccctcagg acaaaaccat aggagagagc tactcccagt agcctgctcc     1980

cagcatcctg ttatagctga tcatgcatcc cttggtgcct gtgtcaacaa ctttattgag     2040

acctaagaat gaaatcttcc tctttatcct gggccaagct gtaatggcag cccccagcag     2100

ctaaatattc taagttaact tctctctctc tctatttccc tccttcctcc ctactccttt     2160

acctttggca gccttattgc cttcttggtg tagcctgcct gttactgttg gtttgcgtaa     2220

aaaaggcaat cgaaagtttt gaatcttggt tttccccagt ctctaagccc atcaaagcaa     2280

tctgagcagc cttaattagt ttgctcctcc agctgttacc tggaactgca tgtgtcagta     2340

aaaaacaata taatcctgag gctgggcgcg gtggctcctg cctgtaatcc cagcactttg     2400

ggaggccaag gtgggtggat caggatgtca agaggtcgag accatcctgg ccaacatggt     2460

gaaacccgtc tctactaaaa atacaaaaat tagctgggca tggtagcgcg tgcctgtagt     2520

tccagctact caggaggctg aggcaggaga attgcttgaa ctcgggagat ggaggttgca     2580

gtgagccaag atttcaccac tgccctccat cctggcgaca gagcgagact ccatcccaaa     2640

aaaaaaaaaa aaaa                                                       2654


<210>  144
<211>  946
<212>  DNA
<213>  Homo sapiens

<400>  144
tcagtcttag acgactgcgt cgtgctatga ccggactttt tcttgaaagg ggatgacagc       60

atgggaggca atggctccac atgtaaaccc gacactgaaa gacaaggcac tctctccaca      120

gcagccccaa caactagccc tgcaccctgt ctctctaacc accacaacaa aaaacattta      180

atccttgcct tttgtgctgg ggttctactg acactgctgc tgatagcctt tatcttcctc      240

atcataaaga gctacagaaa atatcgaagg gagaggcttc ccatttcccc aggcccattg      300

ctgagatggg tccctcttct ttctggcacc atggcagatc actccaagcc ccaggcccca      360

gatcctcact cagatcctcc agccaagctt tcatccatcc caggggaatc acttacctat      420

gccagcacaa ctttcaaact ctcagaagaa aagagcaatc acttggctga gaaccattct      480

gcagactttg accccattgt ctatgctcaa attaaagtaa caaactaact cagcttttcc      540

aatgaggctt gaatccattt cctctcatct cagccctatc ttcacacatc actttcactt      600

ttttacaaat tttggaccac cacctgtgtg aaactgcagt cggagttgtt tagatgtgat      660

ctggcaatgc tatccagcat ctttggagac caatggtcag tcttttcctg gccagaggaa      720

agattgatgg ccctcccact tgaactgaca gcctgtgagc cccttggggg catagactgc      780

cttccttgga cccttccaaa gtgtgtggta cggggctcag tgcacagagt attcacccag      840

catcatgaat caacttggga ggagtcaacc aaatgaacaa tctaccaaaa atttcaaata      900

aagtcaaacc ccccacaaaa aaaaaaaaaa aaaaaaaaaa aaaaaa                     946


<210>  145
<211>  3694
<212>  DNA
<213>  Homo sapiens

<400>  145
tccctttcgg ccgtggggga gggggctcgt gtccccccca acccagcccg gaggccgcgt       60

ccgcccgcgc ccgctctggc ccccgcggag ccgcgcaact tcccgggagc ccgggccaaa      120

gtgagcgcaa agtgctgccc aagttgccgg gatggagctg cagagccggc ccgaggcgct      180

cgccgtggaa ctcgcgcgcc accagaacgg cgacctcaag aagcagctcc acgaaaggca      240

gccgcggatc gccgcgctca gcgacaaaca agctttggga acgatcactg cagtgcctgt      300

cacgggtcct caggtcagct ccttgcagag gttggccggg caaggagcgg cagtgctacc      360

tcaggttagg ccaaagactc tgattccaga cagcctcccc gttgccccgg gccgggaccg      420

gccacccaag cagcccccaa cattccagaa ggccaccgtg gtcagcgtca agaaccccag      480

cccagccctc cccaccgcca acaacactgt cagccatgtg ccagcgcccg gcagccagcc      540

ccaggccctc gccgagcccg ccgccctcgc ctctccgctg agcagtgcgg gggtggccta      600

cgccatcatc tccacctccc ccagcaatgc cgccgccatg gcccccagca ccgccgtgtc      660

tgtggtcagt gacagcatca aagtccagcc cctcctcatc agtgctgaca acaagcctcc      720

tccacgcctc ctctcttccc ctcaccccgc aacccatcac tgtcccctcc acccctcctc      780

tcttcccctc acccctccct ccccatcact gtccccttca cccctccatg gcatcttcca      840

ggtcatcatc attcagcctc aagtgcagac gcagcccgag agcacggcag agtcgcggcc      900

gcccacagag gagccatctc agggagctca ggccaccaaa aagaagaagg aagaccggcc      960

cccgacccag gagaaccccg agaaaatcgc cttcatggta gcgctaggcc tggttaccac     1020

ggaacatttg gaagaaatcc agagcaagcg acaggagcgg aagagaagaa gcacagccaa     1080

ccctgcctac agcggcctcc tggagaccga gaggaaacgg ctggcctcca actatctcaa     1140

caaccccctg ttcctcacag cgagagccaa tgaggacccc tgctggaaga acgagatcac     1200

ccacgatgag cactgtgccg cctgcaagcg aggggccaac ctgcagccct gcggcacctg     1260

cccgggggcc taccacctca gctgcctgga gccgcccctc aagacggcgc ccaagggcgt     1320

gtgggtgtgc cccaggtgcc agcagaaggc cttaaagaaa gacgagggtg tgccctggac     1380

tgggatgctg gccatcgtgc actcttatgt cacccacaag acagtcaaag aagaggagaa     1440

gcagaagctg ctgcaacgag gcagtgagct gcagaacgag caccagcagc tggaggagcg     1500

ggaccggcgg ctggcgtcag cagtgcagaa atgcctggag ttgaagacaa gcctgctggc     1560

ccgccagagg ggcacccagt catccctgga ccgcctgcgg gccctcctga gactgataca     1620

gggcgagcag ctgctccagg tcaccatgac gaccactagc cctgccccac tgctggccgg     1680

gccctggacc aagccctcag tggcagccac acaccccacc gtccagcacc cccagggcca     1740

caactgaccc cgagggacca gtcttcatac ccacggaaag ttattgggac cctgcttaca     1800

cagcctgggg gttctgtcgg ccttaattca taaacactat gaatttcaga caaaaattaa     1860

ccagacagag gagaggaggg aggaagagct gggcgagagg cctagagcca ggaccaggtg     1920

ggggtgcggc cctgtgccct ccaaattcac agggggtacc taggagccag gtggggtacg     1980

acaggctggg gcacacagtc tccccccggc cacctcgggg ctgcctgggc ctctggcttc     2040

caggccctgc tctccacggc ctccctctgg cccgttggag gggcaggctg aggctgtgga     2100

ggggacaagc acgcccccca gaacgcagtc tccactgagg gcaccgccta ttggtgtcct     2160

gtgggagggc gagctgagaa cacatggact agctgagtgg tagcggtagt tgggacgaga     2220

agcggggtag tggatctagg tagttcctca atgccccacg ctcctaggag gtccccctgg     2280

ggtgggcggg cgggcctggg gcactccgtc gcctttgcag aaccacctgg gcccctttct     2340

gtcagtatta ttagggttac gaattgcagc tgtttaactt gaaagacact gtcggaggtg     2400

agcatctggg cgccgggacg ctgcagtgat ccccgccaga gcctgtgccc ttcctgctcc     2460

gtctttgggg tcctcaaggc tgcctccttc cttttgccaa tctcttggac tcagtttgcc     2520

gttgatgcgt ttttctcatg gagtttctgg gcagagtgga gctgcaaccc tgttgtgggg     2580

ggcagcattt ggcaggtttt ctccttgggg ttgaatcatt caacttaacg actgaagccc     2640

tttcttgtct cctttggaag agccgataag tattccactc ctcccttttt gccagtgcag     2700

acactatgcc aaaaaataac ttcacacttt tgtatggcgt ttttattgtg agatatttaa     2760

tgtgaatggt tggggggact ctggctgact tcctttctgc ttctagtagt ctctgcttca     2820

aggtacaaat gggaacacct cccctcggga agcctggcca agctggaaga tccggcaggt     2880

tttttacgag ccgggtggag ggttggggag gaaagaaagg gcggtggcct cgggaggttc     2940

cggccttcgg ggaccagact tgctgccaag ggcttctgca tccagggtgg gcagtggcag     3000

cttgtcaccc ttgcccgatt cccacatccc agtcctgagg gactcagcac aacaggataa     3060

gcgtccagga gccacgggct cccaccccga gcatatcaca tggtgccgaa ttgcactgaa     3120

cacgcgtgtg tgcatcgcac gcggccacga ccacagacac gcatgcacac acgcagaggt     3180

gcagagcgag gaggccggca aatcccgcag ctgccacggt ccctcctgtc attctcacga     3240

ctccgggaga aactgtgctg tatgatacag atctatttta atacacttac cactgggtga     3300

acaagatttt tatattcttt tattgatgaa caaagtgaac cgtgtgaggc acacgtcttc     3360

tatattggct actctgtgcc aagtatgcat taccgcgtgg cttgcgatgt ccatgtcttc     3420

agcttccttt tctgttggtt tggttttctt cgcggatgga ttgagttaca tgttttaaca     3480

gtgtaatggg aggatctgaa aggttggacc cgggaggggt agctgccgat gtgtcttgag     3540

attgttaggt tttttttgga ccaaggagga ccgtccagtg ggtagtgagg atagagaaaa     3600

agtgtttgtc ttaaatacgc caatgtagtt ttccttcttt acaatgtatt aaactcgatc     3660

gatgatttca aaaacaaaaa aaaaaaaaaa aaaa                                 3694


<210>  146
<211>  1728
<212>  DNA
<213>  Homo sapiens

<400>  146
acgcgagctg actgagggcc ggagcggagc gaggcgacgc ggggaggggc gagggatcgc       60

ggccggtggc tgggggccac ctgctccccg agcaccggcc cccgctccgg ggagcagagt      120

ccggagcggg atccgcggcc cacaggttgc gaggggcggt gttgaagaat gtgtgggcga      180

acatcctgtc acttacctag agatgttctc acgagagctt gcgcctacca ggatcggcgg      240

ggccagcagc ggctcccgga gtggagggac cctgataagt actgcccctc ttacaacaag      300

agtcctcaat ccaacagccc agtgcttctg tctcgactgc actttgataa ggatgcagac      360

tcatctgagc gtatcattgc tcccatgcgc tggggcttgg tcccttcttg gttcaaagaa      420

agtgatcctt ccaagctgca gttcaatact accaactgtc gtagtgatac cgtaatggag      480

aaacggtcat ttaaggtgcc tctgggaaag ggaagacgct gtgtcgtttt agcagatgga      540

ttctatgagt ggcagcgatg tcagggaaca aaccagaggc agccatactt catctatttt      600

cctcaaatca agacagagaa gtcaggtagc attggtgctg cagatagtcc tgagaactgg      660

gagaaagtct gggacaactg gaggctgctg acaatggccg ggatctttga ctgctgggag      720

cccccagagg gaggagatgt cctgtattcc tataccatca tcacagtgga ttcctgcaaa      780

ggcttgagtg acatccacca caggatgcct gccatattag atggagagga ggcagtttct      840

aaatggcttg actttggtga agtctcaact caggaagctc tgaaattaat ccacccaaca      900

gagaacatca ccttccatgc agtctcttct gtggtgaaca actcgcgaaa caacactcct      960

gagtgtctgg ctcctgtcga cttggtggtc aaaaaggagc tcagggcaag tggcagtagc     1020

cagaggatgt tgcagtggtt ggccacaaag tcacccaaaa aggaagactc aaaaacacct     1080

caaaaggaag agtcagatgt tccccagtgg tccagtcagt tcctgcagaa gagtccactc     1140

cccaccaaga gaggcactgc aggactccta gagcaatggc tgaagcggga gaaggaggag     1200

gaacctgtgg ccaagcgtcc ttacagccag tgacacagga ctttcagaga ccaaggccag     1260

ggtctgctgc actgctgttc tgataatagg ttcttaacat tgtatgtata tgtgtttgct     1320

ttgggaggag gtggcactgt gttagttgac agttgtgggc tcatgtagtc ttttttgcca     1380

tgagtaggag cccctagtgg ggctggtgga cagctttgga agaggtgtcc tgctgctgtt     1440

accagccatg tgggccccat aggggcactg cgcctgctgc cctttcctgg cagggctggt     1500

ggagtcttcc ctcaaagcat gccttaccca gctgggaagt ctctgccctg atctggtact     1560

ccttgtagta agctgttttc tgctcagcca ctgggctctt tcactttttt agttcttaaa     1620

aatttatttt taagttctaa aataaaataa aaataagttc ttaaaattta tttttttcct     1680

gaataaattg tatttggtaa acttctgcct aaaaaaaaaa aaaaaaaa                  1728


<210>  147
<211>  1465
<212>  DNA
<213>  Homo sapiens

<400>  147
ttgtctctta agtggggtcg gaataaggtt gtggctagga agatcctgac aacccagggc       60

cagtgagtgt ctcggaagcc tgtgaggggc ggagacccgg cccggggagg tggagaagct      120

cgccggccgc ggaagactag gggtgaggct gctgcgagga agacccggtc agctgtccct      180

tcccccatcg gtcctcttag gggaagtgga gatgtgggcc tcggagctgc gtggcccggg      240

ctgtgcggat tccctaaacg ccgcacttgc gcacagcccc ttacgtaacc gtcagtgccg      300

gggattccct ggagggggtc attctattca accattatac acaccccggg ctcctgccgc      360

cgcgccgccg ccgcctcaca aaatggcggc gcccatagag gagaccgcgg ccgcctcccc      420

ggccccattt tgtgggaggc gagagatctg tcaacatgga aaacctctgc tgaggatgca      480

tccgagtttg gaaaccccac ttaagggatg gagcctgggg gatcacatta aacggaaaat      540

gccaacgact tctaccacct ctacgcgttt ttagtttttc attttctcga aggaagcgcc      600

agaagcctgt ggagtaattg taactagagg gagaacggaa agctgaggtg actgctccgg      660

ggacttggcg cggcgccttg gtggctttgg ttgctcttcc acgctcccgg cagctgacca      720

gaatctcttg gagggtctcc tgggccacct cggccgcgcc agtcgtgcag tgagacttct      780

gtagttttaa aatgccacag tccacggccc ggtcggcacc gctcgcctga atcgtgggct      840

ttgggaacct tggaggctgc tgctccagga actcgcggtc ggccgggagc cggggagctt      900

cgttgctggg agcgggcggt attcgcggac tccggcggcc ctggcgggtc gcggccggga      960

tccgagccgg ggatgacgat gctgatggag ctgatggggc aagagtggga acggagaagt     1020

gcagctttct gcaggctgcg cctcaatcgc taagttccac tctccatcct ctgccgcgct     1080

actcctggca tgtggatcac caagatacaa tttctggtcc tgtctgttct tattgatgtc     1140

ctttacagtt aataaatttg attgccacta atcagtctgt atctcttgca aaaacaccac     1200

atttagcatc caagtagagt cagagtatgt tttttatgag attgtactaa agtaaccttc     1260

tattacattt cttattacca tattgcattt cctatagtgg gcagcataga gcaggtggat     1320

cctgacaaag taatgttaga gatgtgctga cagctttaca atagatattc tccaactaat     1380

ttgacaagat ataaaataaa atgtagttcg tagttttcaa gcattaatgg aaagtgttcc     1440

tattaaaaaa ttaccaataa cagtg                                           1465


<210>  148
<211>  3412
<212>  DNA
<213>  Homo sapiens

<400>  148
taactccagg acgagaccgg agcgacccgc gcagcgagca taggcggcga agctgcgccc       60

ggcgcccgag accggcagct gcgtggggcg ggggctgcgc ccgagcccga tctgccggct      120

ccgagcagtg gtctcggaaa gagggtcgtg gtcccgcacg gatgcgcttg ttgggagaaa      180

ccttggagat tcacggcaag gcgtaaagcc tggggcttcc aacgatactc tgggcaggga      240

tggaagccta gatgcctcac cgcaaggagc ggccgagcgg gtcctcgctt cacacacacg      300

gcagcaccgg caccgcggag ggaggaaaca tgtcccggct gtctctcacc cggtcgcctg      360

tgtctcccct ggctgcccag ggcatccccc tgccagccca gctcaccaag tccaatgcac      420

ctgtgcacat cgatgtgggc agccacatgt acaccagcag cctggccacg ctcaccaagt      480

accctgactc caggataagc cgcctcttca atggcactga acccatcgtc ctggacagtt      540

tgaagcaaca ttatttcatt gaccgggatg gggagatttt ccgctacgtc ctgagcttcc      600

tgcggacgtc caagctgctg cttccggatg actttaagga cttcagtctg ctgtacgagg      660

aggcgcgcta ctatcagctc cagcccatgg tgcgcgagct ggagcgctgg cagcaggagc      720

aggagcagcg gcgccgcagc cgggcctgtg actgcctggt ggtgcgcgtc acgcccgact      780

tgggcgagcg gatcgcactc agcggcgaga aggccctcat cgaggaggtc ttccccgaga      840

ccggagacgt catgtgcaac tccgtcaacg ccggctggaa ccaggacccc acgcacgtca      900

tccgcttccc gctcaatggc tactgccggc tcaactcggt acaggatgtt ctataaaaat      960

ggcccagagt attttcaaca aagcgtgctt catttgacac ccagagtctg actttggatt     1020

cgaactaaac ccaggcaaca ggcgaggcag gacagaggct gagtggaaag gtggtctgga     1080

gccccttccc tctccctgct gaccttggag tcgcaggcac ccaccagctg ccaagagaat     1140

ccctggaccg gctcttcctg gatgggtcca agaattggac agctcagatg gagtgagggc     1200

ctattttcca acagctcttc gcagacccaa gagcttggca catttccggg ttagggtgga     1260

atgggctttg cagggaagag ggccccctgt gcacgcattc cacagcctgt cggtcagaac     1320

ttgctagttg caggagacgg gtgttacacg cagtcatcag acctcaccct cacagaggca     1380

caaacccaca tagttgtgga cgcctgcaga gactcaaata ttgagaggac ttctcctttt     1440

tctctccctc cagagctccc acgagctgat gcacccccag gcttcaaacc acctggaatg     1500

cacagctcag ggaagctggt ggatgcctag aggctgaagg acagggaact ctccattatt     1560

ggggcaggac tcagggagga cacttggggc catgtgtctg gagagagggc ataggttaca     1620

ccctacagaa taaagaaggg acccaaagcc tctttttgcc tcccggaatc aaggccctga     1680

gggcagcagg atggtggcct gggtggggtc gtccaactag gtttgctaac ctgaggggtc     1740

actgggcctg gccacttctg tccctctggt ggtggaaccc agcacgtggt tctgtaggga     1800

cctttgtcag tgagcaagac tgagatcgtc acaggagaag gtgcccttgc tggctgcccc     1860

agcaggcacc cacctccctg ccaggccaag ccaggtgtcc tcttgcagct tggccttgat     1920

gacctctgtt tcttcctggg caggtcctgg agcggctgtt ccagaggggt ttcagcgtgg     1980

ctgcgtcctg tgggggcggt gtggactcct cccagttcag cgagtatgtg ctttgccggg     2040

aggagcggcg gccgcagccc acccccactg ctgttcgaat caagcaggaa cccctggact     2100

aggccctgct tcagtgccca cctgggcccc cccagggacc tggaaacagt gctggggagt     2160

tctgcctgtg tatacttggc cgtgggcatg agaccgaggg tgaggctgga gggtccaaag     2220

ctggcccagc gagcaccagg gtcccaggtg tcatggcaac agaacgtggg atgctggagg     2280

catgcctgca gaaggactgt tgatgcgacc caaagataca gcggtgggat ctctgctgcc     2340

agctctccca gcccctcagc ttcgcagcct ggcgcagcat cctctgaggc cccggggcct     2400

gttggggcgg ggttggaaga gccgtctgca gctacttcag aggagctgtt tatccctctc     2460

cacgcggggc agactctggc gggtctccta gcgtccgaga gatggcttat ttttctacag     2520

tatttaaaat ggatgcagcc ctaactgcaa aagtcagaga ggctgacaag gaccaatgct     2580

tctttatctg gtgctcagtt ctcagtcaga cgtgcagcat ggctgcaggg tggaccagct     2640

gcctggcatt caggcccaga tgcctgcagg gctggggctc tcgggacaga tgcagggatg     2700

tgtgctgcag ggctgctggg aggagagtgg tgggggcctg agggctgagt gattctgtaa     2760

ccacctgaga ccttcacgtt tgctgccgtt gggggctcag gctgcactcc ccgggtcacc     2820

tgacctgctg cccaggggct tccagtcctg tctgtgtgga ctggcacctg ggctgctgga     2880

gaagtctcct cccgttcgga ccagcctcag ggctgcacgt tacctcagga atgggcccca     2940

ccatgaaggg gcccatctgt cagcagcgtc ttctaggtcc ccagctcagg gagccatccc     3000

cagctccagt tttctcatgc gaatatgcac agttttaatt cacgttgtta cactagcctg     3060

ccgatgagac ccagacacag gcagacctgg cgctcttgac ccctgattcc agtgaggact     3120

ggccctgagg agtccttgca gacctgctgc ctgccccacg acaggcccaa agatggaccc     3180

cccctggcct tgtgacagct ccccaagtgt tctccggtgg agaaactgca gaggactggt     3240

gggcggggct ccccagccat caccatcctg tgtacaatgg ctgtagactt gtatatggct     3300

cctttaatat tgtaaagatg ctgatgtaca attgtcgtgc atttgtgtga acacattgcg     3360

ttcccagtcc atgccataaa tgatgctctc aagcaaaaaa aaaaaaaaaa aa             3412


<210>  149
<211>  636
<212>  DNA
<213>  Homo sapiens

<400>  149
cccacagccg cagccatgct gtgcctcctg ctcaccctgg gcgtggccct ggtctgtggt       60

gtcccggcca tggacatccc ccagaccaag caggacctgg agctcccaaa gttggcaggg      120

acctggcact ccatggccat ggcgaccaac aacatctccc tcatggcgac actgaaggcc      180

cctctgaggg tccacatcac ctcactgttg cccacccccg aggacaacct ggagatcgtt      240

ctgcacagat gggagaacaa cagctgtgtt gagaagaagg tccttggaga gaagactgag      300

aatccaaaga agttcaagat caactatacg gtggcgaacg aggccacgct gctcgatact      360

gactacgaca atttcctgtt tctctgccta caggacacca ccacccccat ccagagcatg      420

atgtgccagt acctggccag agtcctggtg gaggacgatg agatcatgca gggattcatc      480

agggctttca ggcccctgcc caggcaccta tggtacttgc tggacttgaa acagatggaa      540

gagccgtgcc gtttctagct cacctccgcc tccaggaaga ccagactccc acccttccac      600

acctccagag cagtgggact tcctcctgcc ctttca                                636


<210>  150
<211>  1723
<212>  DNA
<213>  Homo sapiens

<400>  150
cgcagatccg ggccgcggct gtggggaggg cgacggagcg ggtgaccttc cggaggcggg       60

agcgagcgag gaggcccggg agcgccgagc gtcgccgccg ccgccgccat gaacaactcg      120

ggcgccgacg agatcgggaa gctcttcgtg ggcggtcttg actggagcac gacccaagag      180

actctgcgca gctacttttc ccaatatgga gaagtcgtag attgtgttat catgaaagat      240

aaaaccacca accagtctcg aggctttggg tttgtcaaat ttaaagaccc aaactgtgtg      300

gggacggtgc tggccagcag accgcacacg ctagatggcc gaaacatcga ccccaagcca      360

tgcacacccc gggggatgca gccggagaga acacggccga aggaaggatg gcagaaagga      420

cccaggagcg attacagtaa atcaaataag atatttgtcg gtggaattcc tcacaattgt      480

ggtgagacag agctcaggga atacttcaag aagttcggag tggtcacgga ggtagtcatg      540

atctatgacg ccgagaagca gaggccccga ggttttggat ttattacttt cgaggacgaa      600

caatcagtgg accaggctgt caacatgcat tttcacgaca tcatgggcaa aaaagtggaa      660

gttaaacgag ctgagcctcg ggacagcaag agccaagcgc cgggacagcc aggtgccagc      720

cagtggggga gccgggttgt gcccaacgct gccaatggct gggcaggcca gcccccgccc      780

acgtggcagc aaggatatgg cccgcaagga atgtgggtgc cggcaggaca ggcgattggt      840

ggctatggac cgccccctgc aggaagagga gcccccccgc cacccccacc gttcacctcc      900

tacatcgtgt ccacccctcc tggaggcttt ccccctcccc agggcttccc tcagggctac      960

ggtgccccgc cacagttcag ttttggctac gggcctccac ctccaccgcc agatcagttt     1020

gcccctccgg gggttcctcc tccaccagcc actcccgggg cagcacctct ggctttccca     1080

ccgcctccgt ctcaggctgc cccggacatg agcaagcccc cgacagctca gccagacttc     1140

ccctatggtc agtatgcagg ttacgggcag gacttgagtg gcttcggaca gggcttctca     1200

gaccccagcc agcagcctcc ttcctacggg ggtccatccg tgccagggtc ggggggcccc     1260

cccgccggcg gcagcggctt tggacgaggg cagaaccaca acgtgcaagg gttccacccc     1320

taccgacgct agcccgcggc gccgcgacgt ctgcacggcc cagacccagg attccaaact     1380

tgtgaactcg tgacaatcac aaacttggcg gcaaagtggc gactcaacct tggggggggg     1440

ggcgggggga gggcgcgagg cttttggagc ggctgtgggt gtcgtctgga ctgaggtttt     1500

taaatatttc tttctctaac ccatcagcac aataaaaaaa agtcactggt tcaacaacag     1560

ggtttaaaaa aaatgtcttc agctttaatt caaaacttca ggtttctttt tcttcctttt     1620

ttttggaaat tattttcctg agccttttgt tttacggtat attgtaaact tttatgttaa     1680

agaaaaaata tacatttaca aattgtgaga tttttaagaa aaa                       1723


<210>  151
<211>  2078
<212>  DNA
<213>  Homo sapiens

<400>  151
gcaacgcaaa gcgcttggta ttgagtctgt ggccgacttc ggttccggtc tctgcagcag       60

ccgtgatcgc ttagtggagt gcttagggta gttggccagg atgccgaata tcaaaatctt      120

cagcggcagc tcccaccagg acttatctca gaaaattgct gaccgcctgg gcctggagct      180

aggcaaggtg gtgactaaga aattcagcaa ccaggagacc tgtgtggaaa ttggtgaaag      240

tgtacgtgga gaggatgtct acattgttca gagtggttgt ggcgaaatca atgacaattt      300

aatggagctt ttgatcatga ttaatgcctg caagattgct tcagccagcc gggttactgc      360

agtcatccca tgcttccctt atgcccggca ggataagaaa gataagagcc gggcgccaat      420

ctcagccaag cttgttgcaa atatgctatc tgtagcaggt gcagatcata ttatcaccat      480

ggacctacat gcttctcaaa ttcagggctt ttttgatatc ccagtagaca atttgtatgc      540

agagccggct gtcctaaagt ggataaggga gaatatctct gagtggagga actgcactat      600

tgtctcacct gatgctggtg gagctaagag agtgacctcc attgcagaca ggctgaatgt      660

ggactttgcc ttgattcaca aagaacggaa gaaggccaat gaagtggacc gcatggtgct      720

tgtgggagat gtgaaggatc gggtggccat ccttgtggat gacatggctg acacttgtgg      780

cacaatctgc catgcagctg acaaacttct ctcagctggc gccaccagag tttatgccat      840

cttgactcat ggaatcttct ccggtcctgc tatttctcgc atcaacaacg catgctttga      900

ggcagtagta gtcaccaata ccatacctca ggaggacaag atgaagcatt gctccaaaat      960

acaggtgatt gacatctcta tgatccttgc agaagccatc aggagaactc acaatggaga     1020

atccgtttct tacctattca gccatgtccc tttataatag agtaacttct gaggcttttt     1080

gagaataaaa tccaccccac ccttgtttcc ccttggtatt tgatgacaaa ttcagcagaa     1140

gacccggctt gctccagtgt agctttctac atcccacatc aggtatatta gagcttatcc     1200

gaactgggga aagacggatt gagattaact gctgggacct cctacctgca ttatctcatt     1260

ctggcttcct tgataattct gtgggccttg cagctttaac tatagctcag ctgctgcaag     1320

atttcagact tttgaggatg ttgtgtgagg gtgtttgact gtgactgggg aagctcagac     1380

tactttgtat gtgaatgctt cagggttttc tttgttgaga acaactagca acaaaggcaa     1440

cccatgtgtg accagttctc cccaaggtct atgctaaatt atagcaagag ccctgggcaa     1500

ccccaaacct agtcctggta gctgagcacc ctgtaaggca ggagcaggca gctcagcttg     1560

agcagacatt gggtgggggg tggggggtgg ttgagggggg aggcagcaca gtgcagcaaa     1620

tgtttcttgg gaggaagaag cctgatccat caccatctgc ttgactatgt agcttggatt     1680

ctcctttgta cctatccctt tcgatttggc tttaccttca tctatcttga tcctttcctg     1740

gccaaatatc ctcttgggcc caaatgaaca ttgtaccata gtcttctgga aagcaaacat     1800

gcttcctgct atgtaattgc taacattcat attagatgat gtgctgtagc ttgatcttcc     1860

ttagcctact gccactgagg cagtaggttt taggtggtat cgtagtgcct tttgattaat     1920

ttaagtattt aattttcatc ttccttcttt ggatctattt ggcctctcaa atgaactgag     1980

attcctgtta aaaaagattg atgttattgt ctcttgtaga ggaaactaat aaagtgtgtg     2040

tacctgtgtg aaaaaaaaaa aaaaaaaaaa aaaaaaaa                             2078


<210>  152
<211>  4006
<212>  DNA
<213>  Homo sapiens

<400>  152
gaagggcaga cagagtgtcc aaaagcgtga gagcacgaag tgaggagaag gtggagaaga       60

gagaagagga agaggaagag gaagagagga agcggaggga actgcggcca ggctaaaagg      120

ggaagaagag gatcagccca aggaggagga agaggaaaac aagacaaaca gccagtgcag      180

aggagaggaa cgtgtgtcca gtgtcccgat ccctgcggag ctagtagctg agagctctgt      240

gccctgggca ccttgcagcc ctgcacctgc ctgccacttc cccaccgagg ccatgggccc      300

aggagttctg ctgctcctgc tggtggccac agcttggcat ggtcagggaa tcccagtgat      360

agagcccagt gtccctgagc tggtcgtgaa gccaggagca acggtgacct tgcgatgtgt      420

gggcaatggc agcgtggaat gggatggccc cccatcacct cactggaccc tgtactctga      480

tggctccagc agcatcctca gcaccaacaa cgctaccttc caaaacacgg ggacctatcg      540

ctgcactgag cctggagacc ccctgggagg cagcgccgcc atccacctct atgtcaaaga      600

ccctgcccgg ccctggaacg tgctagcaca ggaggtggtc gtgttcgagg accaggacgc      660

actactgccc tgtctgctca cagacccggt gctggaagca ggcgtctcgc tggtgcgtgt      720

gcgtggccgg cccctcatgc gccacaccaa ctactccttc tcgccctggc atggcttcac      780

catccacagg gccaagttca ttcagagcca ggactatcaa tgcagtgccc tgatgggtgg      840

caggaaggtg atgtccatca gcatccggct gaaagtgcag aaagtcatcc cagggccccc      900

agccttgaca ctggtgcctg cagagctggt gcggattcga ggggaggctg cccagatcgt      960

gtgctcagcc agcagcgttg atgttaactt tgatgtcttc ctccaacaca acaacaccaa     1020

gctcgcaatc cctcaacaat ctgactttca taataaccgt taccaaaaag tcctgaccct     1080

caacctcgat caagtagatt tccaacatgc cggcaactac tcctgcgtgg ccagcaacgt     1140

gcagggcaag cactccacct ccatgttctt ccgggtggta gagagtgcct acttgaactt     1200

gagctctgag cagaacctca tccaggaggt gaccgtgggg gaggggctca acctcaaagt     1260

catggtggag gcctacccag gcctgcaagg ttttaactgg acctacctgg gacccttttc     1320

tgaccaccag cctgagccca agcttgctaa tgctaccacc aaggacacat acaggcacac     1380

cttcaccctc tctctgcccc gcctgaagcc ctctgaggct ggccgctact ccttcctggc     1440

cagaaaccca ggaggctgga gagctctgac gtttgagctc acccttcgat accccccaga     1500

ggtaagcgtc atatggacat tcatcaacgg ctctggcacc cttttgtgtg ctgcctctgg     1560

gtacccccag cccaacgtga catggctgca gtgcagtggc cacactgata ggtgtgatga     1620

ggcccaagtg ctgcaggtct gggatgaccc ataccctgag gtcctgagcc aggagccctt     1680

ccacaaggtg acggtgcaga gcctgctgac tgttgagacc ttagagcaca accaaaccta     1740

cgagtgcagg gcccacaaca gcgtggggag tggctcctgg gccttcatac ccatctctgc     1800

aggagcccac acgcatcccc cggatgagtt cctcttcaca ccagtggtgg tcgcctgcat     1860

gtccatcatg gccttgctgc tgctgctgct cctgctgcta ttgtacaagt ataagcagaa     1920

gcccaagtac caggtccgct ggaagatcat cgagagctat gagggcaaca gttatacttt     1980

catcgacccc acgcagctgc cttacaacga gaagtgggag ttcccccgga acaacctgca     2040

gtttggtaag accctcggag ctggagcctt tgggaaggtg gtggaggcca cggcctttgg     2100

tctgggcaag gaggatgctg tcctgaaggt ggctgtgaag atgctgaagt ccacggccca     2160

tgctgatgag aaggaggccc tcatgtccga gctgaagatc atgagccacc tgggccagca     2220

cgagaacatc gtcaaccttc tgggagcctg tacccatgga ggccctgtac tggtcatcac     2280

ggagtactgt tgctatggcg acctgctcaa ctttctgcga aggaaggctg aggccatgct     2340

gggacccagc ctgagccccg gccaggaccc cgagggaggc gtcgactata agaacatcca     2400

cctcgagaag aaatatgtcc gcagggacag tggcttctcc agccagggtg tggacaccta     2460

tgtggagatg aggcctgtct ccacttcttc aaatgactcc ttctctgagc aagacctgga     2520

caaggaggat ggacggcccc tggagctccg ggacctgctt cacttctcca gccaagtagc     2580

ccagggcatg gccttcctcg cttccaagaa ttgcatccac cgggacgtgg cagcgcgtaa     2640

cgtgctgttg accaatggtc atgtggccaa gattggggac ttcgggctgg ctagggacat     2700

catgaatgac tccaactaca ttgtcaaggg caatgcccgc ctgcctgtga agtggatggc     2760

cccagagagc atctttgact gtgtctacac ggttcagagc gacgtctggt cctatggcat     2820

cctcctctgg gagatcttct cacttgggct gaatccctac cctggcatcc tggtgaacag     2880

caagttctat aaactggtga aggatggata ccaaatggcc cagcctgcat ttgccccaaa     2940

gaatatatac agcatcatgc aggcctgctg ggccttggag cccacccaca gacccacctt     3000

ccagcagatc tgctccttcc ttcaggagca ggcccaagag gacaggagag agcgggacta     3060

taccaatctg ccgagcagca gcagaagcgg tggcagcggc agcagcagca gtgagctgga     3120

ggaggagagc tctagtgagc acctgacctg ctgcgagcaa ggggatatcg cccagccctt     3180

gctgcagccc aacaactatc agttctgctg aggagttgac gacagggagt accactctcc     3240

cctcccacaa acttcaactc ctccatggat ggggcgacac ggggagaaca tacaaactct     3300

gccttcggtc atttcactca acagctcggc ccagctctga aacttgggaa ggtgagggat     3360

tcaggggagg tcagaggatc ccacttcctg agcatgggcc atcactgcca gtcaggggct     3420

gggggctgag ccctcacccc cccctcccct actgttctca tggtgttggc ctcgtgtttg     3480

ctatgccaac tagtagaacc ttctttccta atccccttat cttcatggaa atggactgac     3540

tttatgccta tgaagtcccc aggagctaca ctgatactga gaaaaccagg ctctttgggg     3600

ctagacagac tggcagagag tgagatctcc ctctctgaga ggagcagcag atgctcacag     3660

accacactca gctcaggccc cttggagcag gatggctcct ctaagaatct cacaggacct     3720

cttagtctct gccctatacg ccgccttcac tccacagcct cacccctccc acccccatac     3780

tggtactgct gtaatgagcc aagtggcagc taaaagttgg gggtgttctg cccagtcccg     3840

tcattctggg ctagaaggca ggggaccttg gcatgtggct ggccacacca agcaggaagc     3900

acaaactccc ccaagctgac tcatcctaac taacagtcac gccgtgggat gtctctgtcc     3960

acattaaact aacagcatta atgcagtcaa aaaaaaaaaa aaaaaa                    4006


<210>  153
<211>  3975
<212>  DNA
<213>  Homo sapiens

<400>  153
cggagggacc gggcgggaga gagagaaagc ctgaccgacc ggctggcgaa gagctgcatg       60

caaccggtgg gaggccgggc cggctgggtc tggggctcgg gctcaggctc gcaccgtttc      120

tcggcaggtc cctggcggtg agcgcggacg gcccggaggc ggcggctctg agctggcagg      180

cggagggctg tctcctgcgc ccgcctgccc ggcgcggtcc gaggatgcgg gggggcgatg      240

cccggggcca gggacgcgct ctgtcaccag gcgctgcagc tgctggccga gctctgtgcc      300

cgtggggccc tggagcacga cagctgccag gatttcattt accacctgcg ggaccgtgcc      360

agaccccggc tccgcgaccc agatatctca gtgagcctgc tgacccttgt ggtcactgcc      420

tgtggtctcg ctctctttgg cgtgtctctc ttcgtatctt ggaaactctg ctgggttccg      480

tggcgagaac gaggcctgcc ctctggtagc aaagacaaca accaggagcc ccttaactac      540

atggacacag agaccaatga gcaggagaac agtgaggact tcctagaccc tcccacgccc      600

tgccctgact cctccatgaa gatcagccac acctcccctg acattcccct ctccacccag      660

acggggatcc aggagaactg tgcccatggc gtccgcgtgc agcgccaagt cacagagcca      720

acctcgtcgg cccggcataa ttcaatccga agacaactca acttgtcaaa cccggacttc      780

aatatccagc agcttcaaaa acaggaacag ttgactggaa ttggtagaat taaaccagag      840

ttatataagc agaggtcatt ggataatgat gacgggagac ggagtaacag caaggcttgt      900

gggaaactga acttcatttt aaaatatgac tgtgacttag agcagctcat agtgaagatt      960

cacaaagctg tcaatttgcc cgccaaggac ttttctggga cttcagatcc ttatgtcaag     1020

atctatttgc ttcctgatcg gaaaacaaaa caccagacta aagttcacag aaagaccctg     1080

aaccctgtgt ttgatgaagt gtttttattt ccggttccct acaatgacct tgaagcacgg     1140

aagcttcact tctctgtgta cgactttgac aggttctctc gtcatgactt aatcggccaa     1200

gtggtggtgg atcacttcct agacttggct gatttcccca gggagtgcat cctttggaag     1260

gatatcgaat atgtcaccaa tgacaacgtg gatctgggag agctgatgtt ttccctgtgc     1320

tatcttccaa cggctggcag gctgaccatt accattataa aagcaaggaa tttaaaggca     1380

atggacataa caggagcatc agatccctat gtgaaagtct cgctgatgtg tgatggcaga     1440

cgactgaaga agaggaaaac atccaccaag aggaacacct tgaatcctgt ttacaacgaa     1500

gccatagtct ttgatgtccc tcccgagaac attgaccaaa tccacttgtc catagcagtc     1560

atggactatg accgtgtagg tcacaatgag atcatcggcg tgtgtcaagt aggcaacgag     1620

gctgagaggc tgggcagaga ccactggagt gaaatgttgt catatcctcg gaagcccatt     1680

gcacactggc attccctggt ggagaaacga tgaccatggg taagaggact gcttgtgcca     1740

aggacaaaat aggacaacca tctcacaaag atcttaagta actttttcca tccagcaaca     1800

tccagacgat ttcagtgacc aaatgctcag ctgtaaccac agcactaact ggccttcttt     1860

ccagattggg tttggtgaac ctgaatggtc cagccacctt ctgcaggtgg cccaaggtga     1920

tgtgctgcag ggaagcatgt ctctcatgcc aagaaccaag atcggactat gaacaaaaac     1980

aaatgataga tatagtgaca gtaccaagag taccaggact cagtgtttca tatgaagccc     2040

ttggtgatga ggacatagca tctgccctgg aaatcgttat tccaacataa tattattttc     2100

tagaatgccc tggaaggaca gaatatttaa aaatatatcc aggtgctaaa taggcagcag     2160

atctcaattc acacatgact acctttgagc taatgactgt ctccagaaaa taactgtgcc     2220

ccaagaagtg ctccagattt gcaaggaata gccccaagag aataccaaga caagcaggct     2280

gttccctgga aaaaatctaa tgcaaggagg gctagttcac agcaaattca ctgcctcctc     2340

ccatgcacgt ggtagagagt accagtatca acatggccct gttttctgct aaaaccagat     2400

tttgaggaat cagagacccc caacactact cactcagtag ctagcagccc cttcctttca     2460

actgggagtg ttattagaat gaaaagtaat tagttagaag ggcatacatc tcagtggcat     2520

gagcattgtg gaatatcctt tcctaggcac atttgtccac taagggaaca gcctcagaaa     2580

ctggtacagc aatgggtgag atgagatcct ggagagagaa cacagccatc ccctatagaa     2640

aggcacagct tttgggcttc tctggcctga atgccttctg gggtatttcc atatgcaaca     2700

gcccagagtc atagccttgg gcaaccacac atagaggttt ccttctcact tcagacacat     2760

acatcacttt cacaccactt ggggatggaa atacctacaa gagtgaaggt caagggccct     2820

ccccaggcat ctcattcatt actcagcttc cttcctgacc aagtctgcca accaatggcc     2880

agctatgcgc ctcatcctca ttgcttctgc ctccacgtaa atgaaaccaa aggcctcagc     2940

atatcctggg aggactgggg gctgttacct aatggtcctc tctgtcccat tataggtgca     3000

aggcacccca tccacacatt tgcaccacta ctccaagata gtatttttct tttcacacaa     3060

tctctttaca gcagaatcca gagttggatt gtagtttacc ttcctggaaa gctcattatc     3120

tttgtttgaa ttaacatttc agcatggaac taactgggcg gaggaaggat cgttatacgt     3180

cttcagaaag ttctcattgc cccagctgcc tagtactata caagaagctc tactttgatg     3240

gcagatctaa gaaggctata ggcctttgtt tgtaggaagc agtgtcatta cattcaagct     3300

tcacttctct gattggcttc caaccactgg gattcaaaga gaatccaagg ttctgcctat     3360

gtctgatgac ataaggaaaa cttggcttcc tctgctcaag gttcccctct gctcatccct     3420

cctcattcag acatcctcca ccataccagt gtttagaagc aaaacatgaa gggctagcgc     3480

caccaggata gttagcagaa ctattgtctg taaagctagg cagatgagcc cagaagaatg     3540

gtcccagaga aagcagactg gctccaatag atatcaggca gcaatcccaa taaattctga     3600

catgtccttg gcaatggaag cctgggttgg agatcctgag gcagctgtgc ctactgttcc     3660

ccacctcaga agcttcctgc ccagagagcc agcagccttg ggatactaat gaggatgcaa     3720

ctggcttatt ggtatgaaat agaaggtggc tttgtagggg caagcaggca aagagtacta     3780

tccacatggc aggcaggtgg ctttgtgtct ggaaagcttt gcctagccag tacagctgtg     3840

agcagaggct ggttataaat ttgaactccc tcagcccatt tgcaactctg cctctgttct     3900

cttgcattct gtttggttgc cctttagttt cctagtaaat gctccttttg aaaaaaaaaa     3960

aaaaaaaaaa aaaaa                                                      3975


<210>  154
<211>  1903
<212>  DNA
<213>  Homo sapiens

<400>  154
gcagcagccg agtctgacgg cgccggttcg ctgcccggtc cgcccgcgat gccgtagggc       60

caggtgagct gctgtgaagg actcattctt ggtagccggc agttactggc aacttgtgag      120

cttggtgggc tcctactaac gcacctggga caccaggctg ctgggctccc ctctaggcag      180

cctcccctcc aggcagcctc accagcagct cccctgagcc atggagaccc cagaggtccc      240

cgtgggctcg ctaatcgact ttgggcctga ggcacccacc tcttctcccc tggaggcacc      300

accccctgtg ctgcaggacg gcgatggctc cctgggggac ggtgcatcag agagtgagac      360

cactgagtct gcggacagtg agaatgacat gggcgagtcg ccctcgcacc cgtcctggga      420

ccaagaccgc cgttcctcct ccaacgagtc cttctcctcc aaccagagca ccgagtctac      480

ccaggatgaa gagaccctgg cactcaggga cttcatgcgt ggctacgtgg agaagatctt      540

ctctggaggg gaggacttgg atcaggagga gaaagccaag tttggagagt actgcagcag      600

tgaaaatgga aaaggccggg agtggtttgc tcgatacgtg agtgcccagc gctgcaactc      660

caagtgtgtc tcagaggcaa ccttctaccg cctggtgcag tcttttgcag tggtgctgtt      720

cgagtgtcat cagatggatg actttgggcc tgccaagaac ctcatgacca tgtgcttcac      780

ctactaccac atcggaaaac cacagctgct gcccccggag tcccgggaga agcccgcggg      840

cagcatcgac tcctacctga aatccgcaaa cagctggctg gccgaaaaga aggacatcgc      900

cgagcggctg ctgaagaaca cctcggccag gactgagaat gtcaagggct tcttcggggg      960

gctggagacc aagctgaagg ggcccctggc caggaggaac gaggaagacg agaacaaacc     1020

ccaggagaag cggcccaggg ctgtgaccgc gtacagcccc gaggacgaaa agaaggggga     1080

gaagatctac ctgtacacgc acctgaagca acagcccatc tggtaaggcc gagcccgcgg     1140

cttcccgtca ccctcttact gacggggcca gcagtcactc cccgggatca cttctagctg     1200

cctttgtccc catcagaatg gcagaattct cacactcacc agagtggcag aataaaaaga     1260

tgaacactca caggcgttgg tgaggatgtg gagaaactgg agctctcctg tatggctagg     1320

agcaatgtaa atgagcagcc gctgagaaac agtctggcag ttcctttaaa ggtgaaacac     1380

aagagttact ctgtgaccca gcagctccac tcctaggagt cgcccaagag aaaaacatgt     1440

cctcacaaaa ccttgtacac aaatgtctgt agcaacgtcg tttattatgg ccccgaggtg     1500

gaaaccacct tcatggctgt ccagtgatga atgggtaaac aaaatgtggt ccatccgttg     1560

catggactat tagccagcca tgaaaagcaa tggcatgctg ctccacgctg tagcagggat     1620

agacctggga aacatcgtga aactcagtgg aagaagccag acacagaagc ccaagtattg     1680

tatcatccct atgaaatgtc cagaactgca gattcctaga gacacagcag atgacagatt     1740

gcccgggcag agggtgggga atggggagca gggcgtgact gctgatgggg atggggcttc     1800

tttatggggt gagagaatgt tctggaaatg gtggtggctg cacaactctg tgaatacact     1860

aaaaatcact gaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaa                       1903


<210>  155
<211>  2340
<212>  DNA
<213>  Homo sapiens

<400>  155
ggggattcaa catggcggcg ggagtgtccg cggtggtggc ggtgcaagag agctgaagga       60

ggcgcgaggg cgcggagttc caggccgagc agttaggccg cgagcgactg cggcgccgag      120

ccgatgagta acccgaagcc cctagaggag tggtcacctg cctgagggca cttctgtccc      180

accagcatca gaccaggccg caccgagtcc ccggcaccat gtttgggaag aggaagaagc      240

gggtggagat ctccgcgccg tccaacttcg agcaccgcgt gcacacgggc ttcgaccagc      300

acgagcagaa gttcacgggg ctgccccgcc agtggcagag cctgatcgag gagtcggctc      360

gccggcccaa gcccctcgtc gaccccgcct gcatcacctc catccagccc ggggccccca      420

agaccatcgt gcggggcagc aaaggtgcca aagatggggc cctcacgctg ctgctggacg      480

agtttgagaa catgtcggtg acacgctcca actccctgcg gagagacagc ccgccgccgc      540

ccgcccgtgc ccgccaggaa aatgggatgc cagaaaagcc ccctggcccc cgctcaccac      600

agcgggagcc acagcgagta tcccatgagc agttccgggc tgccctgcag ctggtggtgg      660

acccaggcga cccccgctcc tacctggaca acttcatcaa gattggcgag ggctccacgg      720

gcatcgtgtg catcgccacc gtgcgcagct cgggcaagct ggtggccgtc aagaagatgg      780

acctgcgcaa gcagcagagg cgcgagctgc tcttcaacga ggtggtaatc atgagggact      840

accagcacga gaatgtggtg gagatgtaca acagctacct ggtgggggac gagctctggg      900

tggtcatgga gttcctggaa ggaggcgccc tcaccgacat cgtcacccac accaggatga      960

acgaggagca gatcgcggcc gtgtgccttg cagtgctgca ggccctgtcg gtgctccacg     1020

cccagggcgt catccaccgg gacatcaaga gcgactcgat cctgctgacc catgatggca     1080

gggtgaagct gtcagacttt gggttctgcg cccaggtgag caaggaagtg ccccgaagga     1140

agtcgctggt cggcacgccc tactggatgg ccccagagct catctcccgc cttccctacg     1200

ggccagaggt agacatctgg tcgctgggga taatggtgat tgagatggtg gacggagagc     1260

ccccctactt caacgagcca cccctcaaag ccatgaagat gattcgggac aacctgccac     1320

cccgactgaa gaacctgcac aaggtgtcgc catccctgaa gggcttcctg gaccgcctgc     1380

tggtgcgaga ccctgcccag cgggccacgg cagccgagct gctgaagcac ccattcctgg     1440

ccaaggcagg gccgcctgcc agcatcgtgc ccctcatgcg ccagaaccgc accagatgag     1500

gcccagcgcc cttcccctca accaaagagc cccccgggtc acccccgccc cactgaggcc     1560

agtagggggc caggcctccc actcctccca gcccgggaga tgctccgcgt ggcaccaccc     1620

tccttgctgg gggtagatga gaccctacta ctgaactcca gttttgatct cgtgactttt     1680

agaaaaacac agggactcgt gggagcaagc gaggctccca ggacccccac cctctgggac     1740

aggccctccc ccatgttctt ctgtctccag gaagggcagc ggccctccca tcactggaag     1800

tctgcagtgg gggtcgctgg gggtggagag aacactaaga ggtgaacatg tatgagtgtg     1860

tgcacgcgtg tgagtgtgca tgtgtgtgtg tgtgcaaagg tccagccacc ccgtcctcca     1920

gcccgcaagg ggtgtctggc gccttgcctg acacccagcc ccctctcccc ctgagccatt     1980

gtgggggtcg atcatgaatg tccgaagagt ggccttttcc cgtagccctg cgcccccttt     2040

ctgtggctgg atggggagac aggtcagggc cccccaccct ctccagcccc tgcagcaaat     2100

gactactgca cctggacagc ctcctctttt ctagaagtct atttatattg tcattttata     2160

acactctagc ccctgccctt attgggggac agatggtccc tgtcctgcgg ggtggccctg     2220

gcagaaccac tgcctgaaga accaggttcc tgcccggtca gcgcagcccc agcccgccca     2280

cccctgcctc gagttagttt tacaattaaa acattgtctt gtaaaaaaaa aaaaaaaaaa     2340


<210>  156
<211>  1946
<212>  DNA
<213>  Homo sapiens

<400>  156
gcttctgagc ggaaactgaa agtgaaatag ggagctggct accagcgttg agtcccctgt       60

aaagccaaac cccctaaagg tctccacact gctgtttaac ggcacacttg acaatggctt      120

cagcagcacg cttgacaatg atgtgggagg aggtcacatg ccctatctgc ctggacccct      180

tcgtggagcc tgtgagcatc gagtgtggcc acagcttctg ccaggaatgc atctctcagg      240

ttgggaaagg tgggggcagc gtctgtcctg tgtgccggca gcgctttctg ctcaagaatc      300

tccggcccaa tcgacagcta gccaacatgg tgaacaacct taaagaaatc agccaggagg      360

ccagagaggg cacacagggg gaacggtgtg cagtgcatgg agagagactt cacctgttct      420

gtgagaaaga tgggaaggcc ctttgctggg tatgtgccca gtctcggaaa caccgtgacc      480

acgccatggt ccctcttgag gaggctgcac aggagtacca ggagaagctc caggtggcat      540

taggggaact gagaagaaag caggagttgg ctgagaagtt ggaagtggaa attgcaataa      600

agagagcaga ctggaagaaa acagtggaaa cacagaaatc taggattcac gcagagtttg      660

tgcagcaaaa aaacttcctg gttgaagaag aacagaggca gctgcaggag ctggagaagg      720

atgagaggga gcagctgaga atcctggggg agaaagaggc caagctggcc cagcagagcc      780

aggccctaca ggagctcatc tcagagctag atcgaaggtg ccacagctca gcactggaac      840

tgctgcagga ggtgataatt gtcctggaaa ggagtgagtc ctggaacctg aaggacctgg      900

atattacctc tccagaactc aggagtgtgt gccatgtgcc agggctgaag aagatgctga      960

ggacatgtgc agtccacatc actctggatc cagacacagc caatccgtgg ctgatacttt     1020

cagaagatcg gagacaagtg aggcttggag acacccagca gagcatacct ggaaatgaag     1080

agagatttga tagttatcct atggtcctgg gtgcccagca ctttcactct ggaaaacatt     1140

actgggaggt agatgtgaca ggaaaggagg cctgggacct gggtgtctgc agagactctg     1200

tgcgcaggaa ggggcacttt ttgcttagtt ccaagagtgg cttctggaca atttggttgt     1260

ggaacaaaca aaaatatgag gctggcacct acccccagac tcccctccac cttcaggtgc     1320

ctccatgcca agttgggatt ttcctggact atgaggctgg catggtctcc ttctacaaca     1380

tcactgacca tggctccctc atctactcct tctctgaatg tgcctttaca ggacctctgc     1440

ggcccttctt cagtcctggt ttcaatgatg gaggaaaaaa cacagcccct ctaaccctct     1500

gtccactgaa tattggatca caaggatcca ctgactattg atggctttct ctggacactg     1560

ccactctccc cattggcacc gcttctcagc cacaaaccct gcctcttttc cccatgaact     1620

ctgaaccacc tttgtctctg cagaggcatc cggatcccag caagcgagct ttagcaggga     1680

agtcacttca ccatcaacat tcctgcccca gatggctttg tgattccctc cagtgaagca     1740

gcctccttat atttggccca aactcatctt gatcaaccaa aaacatgttt ctgccttctt     1800

tatgggactt aagttttttt tttctcctct ccatctctag gatgtcgtct ttggtgagat     1860

ctctattata tcttgtatgg tttgcaaaag ggcttcctaa aaataaaaaa taaaatttaa     1920

aaaactgtga aaaaaaaaaa aaaaaa                                          1946


<210>  157
<211>  1248
<212>  DNA
<213>  Homo sapiens

<400>  157
ggcacgaggg ggatgacctt caaaattctt tgcatctcct gcaagcgccg cagcgagacc       60

aacgctgaga ccttcaccga gtggaccttc cgccagaagg gcactgagga gtttgtcaag      120

atcctgcgct atgagaatga ggtgttgcag ctggaggagg atgagcgctt cgagggccgc      180

gtggtgtgga atggcagccg gggcaccaaa gacctgcagg atctgtctat cttcatcacc      240

aatgtcacct acaaccactc gggcgactac gagtgccacg tctaccgcct gctcttcttc      300

gaaaactacg agcacaacac cagcgtcgtc aagaagatcc acattgaggt agtggacaaa      360

gccaacagag acatggcatc catcgtgtct gagatcatga tgtatgtgct cattgtggtg      420

ttgaccatat ggctcgtggc agagatgatt tactgctaca agaagatcgc tgccgccacg      480

gagactgctg cacaggagaa tgcctcggaa tacctggcca tcacctctga aagcaaagag      540

aactgcacgg gcgtccaggt ggccgaatag ccctggccct gggccccgcc tcaaggaaga      600

gccagccgta acggggactc tccaggcacc gcctgccccc agcgtggggg tggcccctcc      660

tgggccccag aaagcctcag agtcctgccg acggagccac tggggtggga gggggcaggg      720

ggcttggctc gcacccccac tttcgcctcc tccagctcct gccccgccgg ccgcgcaccg      780

ccatgcatga tgggtaaagc aatactgccg ctgcccccac cctgcttctg ctgcctgttt      840

ggggaggggg gcggtgaggt gggggcagcg gccccgcacc cctcctcctt gctgatttgc      900

acacattggc cgcttcagac acgcacttct ggggccagcc cctccccgcc tcctccctgc      960

ctggcggcag gggtcgcgat gatgggctgg agcagtttgg ggcagggggt tctgggaccc     1020

actccgactc cccctccccg gcatcatttc ccctcccgct tcctccggct ggacctgggg     1080

tcccccctcc ctgtaatgca ctcctgcccc ggcccaacct cgccctctct caccagcctt     1140

gaactgtggc cacctagaaa ggggcccatt cagcctcgtc tctttacaga agtagttttg     1200

ttcatgaaat aaagactctt ggacttgaaa aaaaaaaaaa aaaaaaaa                  1248


<210>  158
<211>  1912
<212>  DNA
<213>  Homo sapiens

<400>  158
tgcgttttga gtctcgggac ccctgttgga gagactatgg cgctcaacaa gaatcactcg       60

gagggcggcg gagtgatcgt caataacacc gagagcatcc taatgtccta tgatcacgtg      120

gaactcacat tcaatgacat gaagaacgtg ccagaagcct tcaaagggac caagaaaggc      180

actgtctacc ttacccctta ccgggtcatc tttctgtcca agggcaagga tgccatgcag      240

tccttcatga tgccatttta tctcatgaaa gactgtgaga tcaagcagcc cgtatttggt      300

gcaaactaca tcaagggaac agtgaaggcg gaagcgggag gtggctggga aggctctgct      360

tcctacaagt tgactttcac ggcagggggc gccattgagt tcggacagcg gatgctccag      420

gtggcatctc aagcctccag aggtgaagtc cccagtggag cctatggcta ctcttacatg      480

cccagcgggg cctatgtcta tcccccgcca gtcgccaatg gaatgtaccc ctgccctcct      540

ggctacccct atccaccgcc cccacctgag ttctatccag gaccccccat gatggacggg      600

gccatgggat acgtgcagcc cccaccaccg ccctaccctg ggcccatgga acctccggtc      660

agcggccccg atgtcccctc cactcctgca gccgaagcca aggccgcaga agcagccgcc      720

agcgcctatt acaacccagg caatcctcac aacgtctaca tgcccacgag ccagccgccg      780

ccacctccct actacccacc ggaagataag aagacccagt aggccctcct gcctccctgc      840

ctcccaccct catctctcta ccctacccct cccatcgggg ctgtgctggg gcttggggag      900

gggagggggc gccttgttct ccctccaggt ctgatcataa acaattacca ggaactagca      960

ttgtgggaca ttagggcccc cggcctcggg agaggtgccg cccagcttcc catgccagcc     1020

cggagcccac agtgctgccc agcgtacctc cctcaccgtc tggggctctt ctgggagcac     1080

ggagcatccc ctgttcctgt ttcactctca gcttctcccc tcgaagggac tctctggcca     1140

cctcctccac cgcagtccag ctccctcagt ctggcaccca ctgctacact cagcctcatg     1200

agccacttca gaccagccag gtgtcttccc gggccctgcc agaccctgct cacattccct     1260

ctgctggtct gtgctggtct cagaaggcca ccgcgcccgc attccactca gccagggtcc     1320

agctgcagcc cccgccaccc ttccttccct tccctgtcct gggtcatgtt gttgccaccc     1380

tgtgtgactt ttgaagctgt aaaatgagct tccagggctt gggtggcgtc ggggcagggc     1440

cgccgaggct gggaggaagc ccttctgcct tttgctggtg tttctggaat ttgctttccc     1500

tcacctctca cttccttcta gaaggagctt cctgactgga accagagaat gcatgtctgt     1560

ccacttggtg gctgctgggt ggggccggga acaagggccc ctgaccctgt gtgctggccg     1620

ggacctgcca ccagcccccc agcctgcttc ttccccttaa gctttgtgcc cctggatgcg     1680

ctaacattca ctcttgtttg tccctggact ggccatgaag tgaggagatg gttatttaaa     1740

gagaattccc tatttatttg acaaaaaatc cagttaatat attaatgtga aataaaccct     1800

gtttgcacct cgatttgttt gctgaaaatg tgaaatagta aaaatgaaat aactggaaaa     1860

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aa             1912


<210>  159
<211>  2101
<212>  DNA
<213>  Homo sapiens

<400>  159
cgcgcgcggc gaatctcaac gctgcgccgt ctgcgggcgc ttccgggcca ccagtttctc       60

tgctttccac cctggcgccc cccagccctg gctccccagc tgcgctgccc cgggcgtcca      120

cgccctgcgg gcttagcggg ttcagtgggc tcaatctgcg cagcgccacc tccatgttga      180

ccaagcctct acaggggcct cccgcgcccc ccgggacccc cacgccgccg ccaggaggca      240

aggatcggga agcgttcgag gccgagtatc gactcggccc cctcctgggt aaggggggct      300

ttggcaccgt cttcgcagga caccgcctca cagatcgact ccaggtggcc atcaaagtga      360

ttccccggaa tcgtgtgctg ggctggtccc ccttgtcaga ctcagtcaca tgcccactcg      420

aagtcgcact gctatggaaa gtgggtgcag gtggtgggca ccctggcgtg atccgcctgc      480

ttgactggtt tgagacacag gagggcttca tgctggtcct cgagcggcct ttgcccgccc      540

aggatctctt tgactatatc acagagaagg gcccactggg tgaaggccca agccgctgct      600

tctttggcca agtagtggca gccatccagc actgccattc ccgtggagtt gtccatcgtg      660

acatcaagga tgagaacatc ctgatagacc tacgccgtgg ctgtgccaaa ctcattgatt      720

ttggttctgg tgccctgctt catgatgaac cctacactga ctttgatggg acaagggtgt      780

acagcccccc agagtggatc tctcgacacc agtaccatgc actcccggcc actgtctggt      840

cactgggcat cctcctctat gacatggtgt gtggggacat tccctttgag agggaccagg      900

agattctgga agctgagctc cacttcccag cccatgtctc cccagactgc tgtgccctaa      960

tccgccggtg cctggccccc aaaccttctt cccgaccctc actggaagag atcctgctgg     1020

acccctggat gcaaacacca gccgaggatg tacccctcaa cccctccaaa ggaggccctg     1080

cccctttggc ctggtccttg ctaccctaag cctggcctgg cctggcctgg cccccaatgg     1140

tcagaagagc catcccatgg ccatgtcaca gggatagatg gacatttgtt gacttggttt     1200

tacaggtcat taccagtcat taaagtccag tattactaag gtaagggatt gaggatcagg     1260

ggttagaaga cataaaccaa gtctgcccag ttcccttccc aatcctacaa aggagccttc     1320

ctcccagaac ctgtggtccc tgattctgga gggggaactt cttgcttctc attttgctaa     1380

ggaagtttat tttggtgaag ttgttcccat tctgagcccc gggactctta ttctgatgat     1440

gtgtcacccc acattggcac ctcctactac caccacacaa acttagttca tatgctctta     1500

cttgggcaag ggtgctttcc ttccaatacc ccagtagctt ttattttagt aaagggaccc     1560

tttcccctag cctagggtcc catattgggt caagctgctt acctgcctca gcccaggatt     1620

ctttattctg ggggaggtaa tgccctgttg ttaccccaag gcttcttttt tttttttttt     1680

tgggtgaggg gaccctactc tgttatccca agtgctctta ttctggtgag aagaacctta     1740

cttccataat ttgggaagga atggaagatg gacaccaccg gacaccacca gacactagga     1800

tgggatggat ggttttttgg gggatgggct aggggaaata aggcttgctg tttgttctcc     1860

tggggcgctc cctccaactt ttgcagattc ttgcaacctc ctcctgagcc gggattgtcc     1920

aattactaaa atgtaaataa tcacgtattg tggggagggg agttccaagt gtgccctcct     1980

ctcttctcct gcctggatta tttaaaaagc catgtgtgga aacccactat ttaataaaag     2040

taatagaatc agaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa     2100

a                                                                     2101


<210>  160
<211>  1129
<212>  DNA
<213>  Homo sapiens

<400>  160
gctctcggat gcagggagcc tgggcccaaa cagcagcttc cggagtcgga aggagctgag       60

gaagaagact gactgaagga gcttgcgact tttccgcctc ggcaaccgga cccagcagca      120

agcaggacgg gcggcgctct gctactggtc ccgttaagcc agagtagccc aagccctgaa      180

gtcactgctc atccggaatg gaaatcccgc cgaccaacta cccagcctcc agggcggcct      240

tggtggcaca gaactacatc aactaccagc aggggacccc gcacagggtg tttgaggtgc      300

agaaggtcaa acaagccagc atggaggata ttccaggaag aggacataag tatcacctta      360

aatttgctgt tgaagaaatt atacaaaaac aagttaaggt gaactgcaca gctgaagtac      420

tttacccttc aacgggacaa gaaactgcac cagaagtcaa cttcacattt gaaggagaaa      480

ctggaaagaa tccagatgaa gaagacaaca cattttatca aagacttaag tccatgaagg      540

aaccgctaga agcacaaaat attccagaca attttggaaa tgtatctcca gaaatgacgc      600

tcgttctaca tttagcctgg gttgcctgtg gttatataat atggcaaaat tctactgaag      660

acacatggta taaaatggta aaaattcaaa ctgtcaagca agtgcaaaga aatgatgact      720

ttattgaatt agactacacc attctacttc ataatatagc atctcaggag attattccct      780

ggcaaatgca agttctctgg catccacaat acggcactaa agtaaaacat aatagccgtc      840

tgccaaagga agtacaactg gaataaacaa aaaccctaac actggaagtg taaacatgtc      900

tattgatgtg tatgccaatt tcactggcat ctagcttatg aggccaaata atcccaaagt      960

gtcactttat ataaatgtct tgattacagt atagaacttt atagagtcca taatacaaag     1020

tatcactaca taaaaatgtc tttaaaacag taatagtggt atgtatatcc aaaataaaaa     1080

gcttcaattt cagcctcagg aaaaaaaaaa aaaaaaaaaa aaaaaaaaa                 1129


<210>  161
<211>  1439
<212>  DNA
<213>  Homo sapiens

<400>  161
ggcacgaggc ttccctcagc ttgaaacacc tgctgcttcg cggcggtggc tttgtgccac       60

ttttcccagg gcttgggcat cattctggac ccatgttcgg tgaaccggtt actctcagag      120

ctgctttcgg gcgcagctcc tgctgcagcc agggcccgtt ttaagagagg cttccaggtc      180

cagccctccc gctgcagcct gcagggagcg agccggcctg tcccgatgac atagacacta      240

ggtttttaca gcaattctct gatgaccttg atatggtaga acgctgtgta tttcaagagt      300

aagctctcgt ttgaggagac taacaattcc tgttttcgcc agatttcttc ttgaatggca      360

acctaaatgc cagtccaaag aggcccccaa tagacttgtt cacccttcat gtcctcaact      420

ctggggaagt taagtaatca agttgaagaa acacttccac tacttaaaaa ggtacctgca      480

aattactttc acatttgttc agctatccta atgggatttt cacttagtaa atctgctact      540

caggtatctg ctatacatat ggattcaaaa gtggatgatc acttaatacg agggactgaa      600

aaaagcaggt tggaaccagc gactcagtta tttcaaaaca ccaagaaaat aagattagaa      660

gacacaaatc aagaaaactt tacaaggatt gaagggactg gcacaggatc tctttctggg      720

aaagccttgg gttcagtggt atatgtcaaa gaaagtgatg gactagaaat gacagatgtg      780

gaatgaagca atttgtacgt attaccaaag aaaccaaaaa ctgcctttga ctaagggggg      840

tgttgaaaga gaacttaacc ttattaggaa accctgacaa aatgatggaa gactattgcc      900

ttattttgca ctatttgtga atcatcttac actgcatttt tttatgatgc ttattcaaaa      960

ggcagttgct ttagggtgaa aaagccttcc aagattcaaa gcagatttct ctggtattat     1020

attatatcct tcttaaaaac cagagttttt aagtaacagt atttgaatgg catcaaaaca     1080

ttttcatttt aatgtatttc tttaacaagt ggttaaaaaa agtgtccaag cagccgggcg     1140

cagtggctca cacctgtaat cccagcactt tgggaggcca aggcgggtca atcacctgag     1200

gtcaggagtt cgcaaccagc ctggccaata tggtgagacc ccatctctac taaaaatgca     1260

aaaagttagc caggcatggt ggtgggcacc tgtgatccca gctacctggg aggctgagga     1320

aggagaatcg cttgaagcct ggaggcggag gctgcactga gctgaggtca tgccattgta     1380

ctccagcctg ggcaacaaga gcaaaactcc gtctcaaaaa aaaaaaaaaa aaaaaaaaa      1439


<210>  162
<211>  3596
<212>  DNA
<213>  Homo sapiens

<400>  162
gataccattt gacctttcaa aggttctcca gcagtattta actgatgcaa aaggaacaca       60

cttgcaattt tctacttttg acatgacaga ccctcctctt agttcacaca atgttcaaaa      120

ggcacaagtc cctcgcttcg gaacgcaaga gagcattact ttcccaaaga gctacacggt      180

tcatactgaa ggatgatatg agaaattttc actttttgtc aaaacttgta ctctcagcgg      240

gccctctaag accaactcca gcagtcaaac attcaaaaac gactcacttt gagattgaaa      300

tatttgatgc tcaaacaagg aaacagatat gtattctgga taaggtgaca caatcatcta      360

ctattcatga tgttaagcaa aagtttcaca aagcatgtcc aaagtggtac ccttctcgag      420

ttggtctgca gctagaatgt ggcgggcctt ttttgaagga ctacattacc attcaaagta      480

ttgcagcttc ctccattgtc acactgtatg ctacagacct aggtcaacaa gtcagttgga      540

ccacagtgtt tttggctgaa tacacaggac ctctgctaat atacctcctc ttttatttga      600

ggatcccatg tatatatgat ggaaaagaga gtgctagaag attacgccac ccagtggtac      660

acttggcttg cttctgtcat tgtatacact acatccgata ccttttggaa accttatttg      720

ttcacaaagt ttctgcagga cacacacctt tgaaaaattt gataatgagt tgtgcctttt      780

actggggatt tacttcttgg attgcctact acattaatca tccactatat acaccaccat      840

catttggaaa caggcaaatc acagtatctg ctatcaattt tctgatttgt gaagctggga      900

atcatttcat caatgtaatg ttgtctcatc ccaatcacac aggaaacaat gcctgtttcc      960

caagtccaaa ttataacccc ttcacatgga tgtttttcct ggtttcatgt cctaactaca     1020

cctatgagat tggatcatgg attagtttca cagtcatgac acaaacactg ccagttggaa     1080

tttttacact tctgatgagt atccagatgt ctttgtgggc acaaaagaaa cataagattt     1140

atctgagaaa attcaattca tatattcata gaaaatcagc aatgattcca ttcatattgt     1200

aaaaaaagaa tcttatctcc tatagaaaac agcaacatat aaattcaata aataagactt     1260

agttaaggat agttaactat tatactccaa caattcatga gcaacagtat atacactgag     1320

taaaaatata aaatagtaaa atttcactaa atttagagaa atgcacatgg taataaaaag     1380

tataaattat aaatgcaatt aactaagaac agctctgaat gtatttgcat gggattggtc     1440

cttgaataaa attgtcttac ttcattaata cttcacaata ctatttgcat aagacaaaat     1500

accacagcaa aaaaaaaatc tgattaaaaa atgaaaaagc gatctgaaca gacatttccc     1560

aaaggaagac atatacatgg tcaataagta tatttttaaa atgctcaaca ttaactattc     1620

atacagaaat gcaaatcaaa accacaatga gatatcatct catcctaatt aaggtgacta     1680

ttttcaaaaa gacaaaaaat atgacagccg tggtggttca tatctgtaat cctaacactt     1740

tgacaggcca aggcagggga attgcttgag ttcagaagtt tgagatctgg gcaacatatt     1800

gagactctgt ctctaaaaag catattgaga ctctgtctct acaaaaaaat tttaaaaagt     1860

aaaaattagc tgggcgtggt ggcacatgcc agtaggtagt cccagctact cgaggttgct     1920

ccagctcagg cgttcaaggc tagagagagc catgattaaa ccaaggcact ccagcctggg     1980

tgacagagtg agactgtctc aaaataaaat aaaaataaca tattggtgaa gatgcgggga     2040

aaaaaaaaga actcttagac actgctggtg ggaatgtaaa ctagagcagc catgtggaga     2100

acaacatgga gtttcttcaa aaattacaaa tagaactatc atatgatcca gcaataccat     2160

tactggaaaa aggaaatctg tatattaaag agacatttga accctatgtt tactgcagca     2220

ctattcacaa tagccaagat ataggagcaa cctaggtgtc caacaacaga tgaatggata     2280

aagaaaatgt ggtatatata cacaatagaa tactatgcag ccataaaaac cgaattcctg     2340

tcattcagga caacatggat ggaattggag ggcatatgtt aagtgaaaca agccaggaac     2400

agaaagttaa acattgcatg ttattactta tatgtggaag ctaaaaaaat tgatatcata     2460

gaagtaaaaa ataaaacaga ggatactaca ggctgggaaa gctgcagcaa agggagacta     2520

gagagagatt tgttaaagga tacaaagtta cagcttggta ggaggaataa tttctggtgt     2580

tctataccac tgtaggacga ctatagttaa gaacattata ttccatttag tttcaaatag     2640

ctaaaaggag attttgtccc caacaaaaag aaatgataaa tatttgaaac catggatact     2700

ctaatttctc tgatctgacc actataaatt atatgtattg aaacattatt atgtatctcc     2760

caaatatgtt caattcttat gtcgctcaaa aaataaaatt taatttaaaa agtatctgat     2820

ttttaaagta aatatttttt taaagttttg acatttaaat tacttgaatc tcattatttt     2880

gacaataatt taattctttt attgttcaat ctgttagtga gatgtgtcat aggtattatg     2940

tcattagttc aaattcttgt ggaaattata gctacattaa aagtgtaaca tttttattta     3000

gatgtgtact tatttgttaa taatacagac attgtatgtt atcatactgc aatttacaat     3060

taaaatattt tctgtagatt atttgaaaat cattctgaat atatattttg aaatatatag     3120

attatatttg tatgtaaatt atatttatac atctgaaata tatttcaaaa tatgtgtgta     3180

cgtgtgtata tgtgtatata tatacacata tatatacaca tacacaaata tatgcatatt     3240

tcaaatggat tgtatgcact tgcaaagcaa aagtacattg gtaatttggg cacattcaga     3300

gtggaaaaaa tttgttctat ttttacatct ttaaatacct atcttctatg aaagcctatg     3360

tgcatgtgtg tgtgtgtatg agtttctatg tgagcatgca tatatacttc acaaagagat     3420

gacctatata aatcaaagta cacattattt aaaatattta aaagaaattt tcagtttctt     3480

catttttaaa ttgtgatttt tagatttgtt agtctatgga gcattttcaa ttctcagatt     3540

atacatatgt aataaaatat gttcactaaa aaaaaaaaaa aaaaaaaaaa aaaaaa         3596


<210>  163
<211>  1741
<212>  DNA
<213>  Homo sapiens

<400>  163
aaacaatgtc ctccaccgag agaaacgtaa aggacacttg atcacacaat ccctggaata       60

atatccagga aacacttgct ggagccactc gcagcaccct tccctggcag cacacttggg      120

gacagcgagg agatgagcgc atctctgaat tacaaatctt tttccaaaga gcagcagacc      180

atggataact tagagaagca actcatctgt cccatctgct tagagatgtt cacgaaacct      240

gtggtgattc tcccttgtca gcacaacctg tgtaggaaat gtgccagtga tattttccag      300

gcctctaacc cgtatttgcc cacaagagga ggtaccacca tggcatcagg gggccgattc      360

cgctgcccat cctgtagaca tgaagtggtt ttggatagac atggggtata tggacttcag      420

aggaacctgc tggtggaaaa tatcattgac atctacaagc aggagtccac caggccagaa      480

aagaaatccg accagcccat gtgcgaggaa catgaagagg agcgcatcaa catctactgt      540

ctgaactgcg aagtacccac ctgctctctg tgcaaggtgt ttggtgcaca caaagactgc      600

caggtggctc ccctcactca tgtgttccag agacagaagt ctgagctcag tgatggcatc      660

gccatcctcg tgggcagcaa cgatcgagtc cagggagtga tcagccagct ggaagacacc      720

tgcaaaacta tcgaggaatg ttgcagaaaa cagaaacaag agctttgtga gaagtttgat      780

tacctgtatg gcattttgga ggagaggaag aatgaaatga cccaagtcat tacccgaacc      840

caagaggaga aactggaaca tgtccgtgct ctgatcaaaa agtattctga tcatttggag      900

aacgtctcaa agttggttga gtcaggaatt cagtttatgg atgagccaga aatggcagtg      960

tttctgcaga atgccaaaac cctgctaaaa aaaatctcgg aagcatcaaa ggcatttcag     1020

atggagaaaa tagaacatgg ctatgagaac atgaaccact tcacagtcaa cctcaataga     1080

gaagaaaaga taatacgtga aattgacttt tacagagaag atgaagatga agaagaagaa     1140

gaaggcggag aaggagaaaa agaaggagaa ggagaagtgg gaggagaagc agtagaagtg     1200

gaagaggtag aaaatgttca aacagagttt ccaggagaag atgaaaaccc agaaaaagct     1260

tcagagctct ctcaggtgga gctgcaggct gcccctgggg cacttccagt ttcctctcca     1320

gagccacctc cagccctgcc acctgctgcg gatgcccctg tgacacagat tggatttgag     1380

gctcctcccc tccagggaca ggctgcagct ccagcgagtg gcagtggagc tgattctgag     1440

ccagctcgcc atatcttctc cttttcctgg ttgaactccc taaatgaatg atattcattc     1500

caactgctgc ccctctgtct gcctggctga gatgcatgtg ggcagcagga agcccaagtg     1560

aaattaatat tatgcagatg atgaaaggga cctctgaaca ggatttctgc aaaaatagcc     1620

ccaaactgca attccatatg acttatctaa catcttgggg ggaaagaata ttttgagaaa     1680

atagttgcag aaagcactgg aaataataaa cttgatctta tacaaaaaaa aaaaaaaaaa     1740

a                                                                     1741


<210>  164
<211>  1888
<212>  DNA
<213>  Homo sapiens

<400>  164
gcggcgcggg gcgggcgcag cgggggtcgg ggcgctggga gcccgttggg ccgcgaacgc       60

agccgccacg ccggggccgc cgagatcggg tgcccgggat gagcctcatc cggaaaaagg      120

gcttctacaa gcaggacgtc aacaagaccg cctgggagct gcccaagacc tacgtgtccc      180

cgacgcacgt cggcagcggg gcctatggct ccgtgtgctc ggccatcgac aagcggtcag      240

gggagaaggt ggccatcaag aagctgagcc gaccctttca gtccgagatc ttcgccaagc      300

gcgcctaccg ggagctgctg ctgctgaagc acatgcagca tgagaacgtc attgggctcc      360

tggatgtctt caccccagcc tcctccctgc gcaacttcta tgacttctac ctggtgatgc      420

ccttcatgca gacggatctg cagaagatca tggggatgga gttcagtgag gagaagatcc      480

agtacctggt gtatcagatg ctcaaaggcc ttaagtacat ccactctgct ggggtcgtgc      540

acagggacct gaagccaggc aacctggctg tgaatgagga ctgtgaactg aagattctgg      600

attttgggct ggcgcgacat gcagacgccg agatgactgg ctacgtggtg acccgctggt      660

accgagcccc cgaggtgatc ctcagctgga tgcactacaa ccagacagtg gacatctggt      720

ctgtgggctg tatcatggca gagatgctga cagggaaaac tctgttcaag gggaaagatt      780

acctggacca gctgacccag atcctgaaag tgaccggggt gcctggcacg gagtttgtgc      840

agaagctgaa cgacaaagcg gccaaatcct acatccagtc cctgccacag acccccagga      900

aggatttcac tcagctgttc ccacgggcca gcccccaggc tgcggacctg ctggagaaga      960

tgctggagct agacgtggac aagcgcctga cggccgcgca ggccctcacc catcccttct     1020

ttgaaccctt ccgggaccct gaggaagaga cggaggccca gcagccgttt gatgattcct     1080

tagaacacga gaaactcaca gtggatgaat ggaagcagca catctacaag gagattgtga     1140

acttcagccc cattgcccgg aaggactcac ggcgccggag tggcatgaag ctgtagggac     1200

tcatcttgca tggcaccacc ggccagacac tgcccaagga ccagtatttg tcactaccaa     1260

actcagccct tcttggaata cagcctttca agcagaggac agaagggtcc ttctccttat     1320

gtgggaaatg ggcctagtag atgcagaatt caaagatgtc ggttgggaga aactagctct     1380

gatcctaaca ggccacgtta aactgcccat ctggagaatc gcctgcaggt ggggcccttt     1440

ccttcccgcc agagtggggc tgagtgggcg ctgagccagg ccgggggcct atggcagtga     1500

tgctgtgttg gtttcctagg gatgctctaa cgaattacca caaacctggt ggattgaaac     1560

agcagaactt gattccctta cagttctgga ggctggaaat ctgggatgga ggtgttggca     1620

gggctgtggt ccctttgaag gctctgggga agaatccttc cttggctctt tttagcttgt     1680

ggcggcagtg ggcagtccgt ggcattcccc agcttattgc tgcatcactc cagtctctgt     1740

ctcttctgtt ctctcctctt ttaacaacag tcattggatt tagggcccac cctaatcctg     1800

tgtgatctta tcttgatcct tattaattaa acctgcaaat actctagttc caaataaagt     1860

cacattctca ggttccaggt ggacatga                                        1888


<210>  165
<211>  3680
<212>  DNA
<213>  Homo sapiens

<400>  165
tgagtaaatg ccgcagattc tggaaagttc tgatcagtgc gatacataag gctgaggaag       60

tgggacctcc ccttttgggt cggtagttca gcgccggcgc cggtgtgcga gccgcggcag      120

agtgaggcag gcaacccgag gtgcggagcg acctgcggag gctgagcccc gctttctccc      180

agggtttctt atcagccagc cgccgctgtc cccgggggag taggaggctc ctgacaggcc      240

gcggctgtct gtgtgtcctt ctgagtgtca gaggaacggc cagaccccgc gggccggagc      300

agaacgcggc cagggcagaa agcggcggca ggagaagcag gcagggggcc ggaggacgca      360

gaccgagacc cgaggcggag gcggaccgcg agccggccat gtcggtggtg gggttggacg      420

tgggctcgca gagctgctac atcgcggtag cccgggccgg gggcatcgag accatcgcca      480

atgagttcag cgaccggtgc accccgtcag tcatatcatt tggatcaaaa aatagaacaa      540

tcggagttgc agccaaaaat cagcaaatca ctcatgcaaa caatacggtg tctaacttca      600

aaagatttca tggccgagca ttcaatgacc ccttcattca aaaggagaag gaaaacttga      660

gttacgattt ggttccattg aaaaatggtg gagttggaat aaaggtaatg tacatgggtg      720

aagaacatct atttagtgtg gagcagataa cagccatgtt gttgactaag ctgaaggaaa      780

ctgctgaaaa cagcctcaag aaaccagtaa cagattgtgt tatttcagtc ccctccttct      840

ttacagatgc tgagaggcga tctgtgttag atgctgcaca gattgttggc ctaaactgtt      900

taagacttat gaatgacatg acagctgttg ctttgaatta cggaatttat aagcaggatc      960

tcccaagcct ggatgagaaa cctcggatag tggtttttgt tgatatggga cattcagctt     1020

ttcaagtgtc tgcttgtgct tttaacaagg gaaaattgaa ggtactggga acagcttttg     1080

atcctttctt aggaggaaaa aacttcgatg aaaagttagt ggaacatttt tgtgcagaat     1140

ttaaaactaa gtacaagttg gatgcaaaat ccaaaatacg agcactccta cgtctgtatc     1200

aggaatgtga aaaactgaaa aagctaatga gctctaacag cacagacctt ccactgaata     1260

tcgaatgctt tatgaatgat aaagatgttt ccggaaagat gaacaggtca caatttgaag     1320

aactctgtgc tgaacttctg caaaagatag aagtacccct ttattcactg ttggaacaaa     1380

ctcatctcaa agtagaagat gtgagtgcag ttgagattgt tggaggcgct acacgaattc     1440

cagctgtgaa ggaaagaatt gccaaattct ttggaaaaga tattagcaca acactcaatg     1500

cagatgaagc agtagccaga ggatgtgcat tacagtgtgc aatactttcc ccggcattta     1560

aagttagaga attttccgtc acagatgcag ttccttttcc aatatctctg atctggaacc     1620

atgattcaga agatactgaa ggtgttcatg aagtctttag tcgaaaccat gctgctcctt     1680

tctccaaagt tctcaccttt ctgagaaggg ggccttttga gctagaagct ttctattctg     1740

atccccaagg agttccatat ccagaagcaa aaataggccg ctttgtagtt cagaatgttt     1800

ctgcacagaa agatggagaa aaatctagag taaaagtcaa agtgcgagtc aacacccatg     1860

gcattttcac catctctacg gcatctatgg tggagaaagt cccaactgag gagaatgaaa     1920

tgtcttctga agctgacatg gagtgtctga atcagagacc accagaaaac ccagacactg     1980

ataaaaatgt ccagcaagac aacagtgaag ctggaacaca gccccaggta caaactgatg     2040

ctcaacaaac ctcacagtct cccccttcac ctgaacttac ctcagaagaa aacaaaatcc     2100

cagatgctga caaagcaaat gaaaaaaaag ttgaccagcc tccagaagct aaaaagccca     2160

aaataaaggt ggtgaatgtt gagctgccta ttgaagccaa cttggtctgg cagttaggga     2220

aagaccttct taacatgtat attgagacag agggtaagat gataatgcaa gataaattgg     2280

aaaaagaaag gaatgatgct aaaaatgcag ttgaggaata tgtgtatgag ttcagagaca     2340

agctgtgtgg accatatgaa aaatttatat gtgagcagga tcatcaaaat tttttgagac     2400

tcctcacaga aactgaagac tggctgtatg aagaaggaga ggaccaagct aaacaagcat     2460

atgttgacaa gttggaagaa ttaatgaaaa ttggcactcc agttaaagtt cggtttcagg     2520

aagctgaaga acggccaaaa atgtttgaag aactaggaca gaggctgcag cattatgcca     2580

agatagcagc tgacttcaga aataaggatg agaaatacaa ccatattgat gagtctgaaa     2640

tgaaaaaagt ggagaagtct gttaatgaag tgatggaatg gatgaataat gtcatgaatg     2700

ctcaggctaa aaagagtctt gatcaggatc cagttgtacg tgctcaggaa attaaaacaa     2760

aaatcaagga attgaacaac acatgtgaac ccgttgtaac acaaccgaaa ccaaaaattg     2820

aatcacccaa actggaaaga actccaaatg gcccaaatat tgataaaaag gaagaagatt     2880

tagaagacaa aaacaatttt ggtgctgaac ctccacatca gaatggtgaa tgttacccta     2940

atgagaaaaa ttctgttaat atggacttgg actagataac cttaaattgg cctattcctt     3000

caattaataa aatatttttg ccatagtatg tgactctaca taacatactg aaactattta     3060

tattttcttt tttaaggata tttagaaatt ttgtgtatta tatggaaaaa gaaaaaaagc     3120

ttaagtctgt agtctttatg atcctaaaag ggaaaattgc cttggtaact ttcagattcc     3180

tgtggaattg tgaattcata ctaagctttc tgtgcagtct caccatttgc atcactgagg     3240

atgaaactga cttttgtctt ttggagaaaa aaaactgtac tgcttgttca agagggctgt     3300

gattaaaatc tttaagcatt tgttcctgcc aaggtagttt tcttgcattt tgctctccat     3360

tcagcatgtg tgtgggtgtg gatgtttata aacaagacta agtctgactt cataagggct     3420

ttctaaaacc atttctgtcc aagagaaaat gactttttgc tttgatatta aaaattcaat     3480

gagtaaaaca aaagctagtc aaatgtgtta gcagcatgca gaacaaaaac tttaaacttt     3540

ctctctcact atacagtata ttgtcatgtg aaagtgtgga atggaagaaa tgtcgatcct     3600

gttgtaactg attgtgaaca cttttatgag ctttaaaata aagttcatct tatggtgtca     3660

tttctaaaaa aaaaaaaaaa                                                 3680


<210>  166
<211>  1466
<212>  DNA
<213>  Homo sapiens

<400>  166
ggcacgaggc tgccacctag actcggagct ccatccaaac ctccagcgaa gacatcccag       60

ccatggccat gcagaaaatc tttgcccggg aaatcttgga ctccaggggc aaccccacgg      120

tggaggtgga cctgcacacg gccaagggcc gattccgagc agctgtgccc agtggggctt      180

ccacgggtat ctatgaggct ctggaactaa gagacggaga caaaggccgc tacctgggga      240

aaggagtcct gaaggctgtg gagaacatca acagtactct gggccctgct ctgctgcaaa      300

agaaactaag cgttgcggat caagaaaaag ttgacaaatt tatgattgag ctagatggga      360

ccgagaataa gtccaagttt ggggccaatg ccatcctggg cgtgtccttg gccgtgtgta      420

aggcgggagc agctgagaag ggggtccccc tgtaccgcca catcgcagat ctcgctggga      480

accctgacct catactccca gtgccagcct tcaatgtgat caacgggggc tcccatgctg      540

gaaacaagct ggccatgcag gagttcatga ttctgcctgt gggagccagc tccttcaagg      600

aagccatgcg cattggcgcc gaggtctacc accacctcaa gggggtcatc aaggccaagt      660

atgggaagga tgccaccaat gtgggtgatg aaggtggctt cgcacccaac atcctggaga      720

acaatgaggc cctggagctg ctgaagacgg ccatccaggc ggctggttac ccagacaagg      780

tggtgatcgg catggatgtg gcagcatctg agttctatcg caatgggaag tacgatcttg      840

acttcaagtc gcctgatgat cccgcacggc acatcactgg ggagaagctc ggagagctgt      900

ataagagctt tatcaagaac tatcctgtgg tctccatcga agaccccttt gaccaggatg      960

actgggccac ttggacctcc ttcctctcgg gggtgaacat ccagattgtg ggggatgact     1020

tgacagtcac caaccccaag aggattgccc aggccgttga gaagaaggcc tgcaactgtc     1080

tgctgctgaa ggtcaaccag atcggctcgg tgaccgaatc gatccaggcg tgcaaactgg     1140

ctcagtctaa tggctggggg gtgatggtga gccaccgctc tggggagact gaggacacat     1200

tcattgctga ccttgtggtg gggctctgca caggacagat caagactggc gccccctgcc     1260

gctcggagcg tctggccaaa tacaaccaac tcatgaggat cgaggaggct cttggggaca     1320

aggcaatctt tgctggacgc aagttccgta acccgaaggc caagtgagaa gctggaggct     1380

ccaggactcc actggacaga cccaggtctt ccagacctgc ttcctgaaat aaacactggt     1440

gccaaccaaa aaaaaaaaaa aaaaaa                                          1466


<210>  167
<211>  2109
<212>  DNA
<213>  Homo sapiens

<400>  167
gattcggccg gagctgccag cggggaggct gcagccgcgg gttgttacag ctgctggagc       60

agcagcggcc cccgctcccg ggaaccgttc ccgggccgtt gatcttcggc cccacacgaa      120

cagcagagag gggcagcagg atgaatgtgg gcacagcgca cagcgaggtg aaccccaaca      180

cgcgggtgat gaacagccgt ggcatctggc tctcctacgt gctggccatc ggtctcctcc      240

acatcgtgct gctgagcatc ccgtttgtga gtgtccctgt cgtctggacc ctcaccaacc      300

tcattcacaa catgggcatg tatatcttcc tgcacacggt gaaggggaca ccctttgaga      360

ccccggacca gggcaaggcg aggctgctaa cccactggga gcagatggat tatggggtcc      420

agttcacggc ctctcggaag ttcttgacca tcacacccat cgtgctgtac ttcctcacca      480

gcttctacac taagtacgac cagatccatt ttgtgctcaa caccgtgtcc ctgatgagcg      540

tgcttatccc caagctgccc cagctccacg gagtccggat ttttggaatc aataagtact      600

gagagtgcag ccccttcccc tgcccagggt ggcaggggag gggtagggta aaaggcatgt      660

gctgcaacac tgaagacaga aagaagaagc ctctggacac tgccagagat gggggttgag      720

cctctggcct aatttccccc ctcgcttccc ccagtagcca acttggagta gcttgtagtg      780

gggttggggt aggccccctg ggctctgacc ttttctgaat tttttgatct cttccttttg      840

ctttttgaat agagactcca tggagttggt catggaatgg gctgggctcc tgggctgaac      900

atggaccacg cagttgcgac aggaggccag gggaaaaacc cctgctcact tgtttgccct      960

caggcagcca aagcacttta acccctgcat agggagcaga gggcggtacg gcttctggat     1020

tgtttcactg tgattcctag gttttttcga tgccatgcag tgtgtgcttt tgtgtatgga     1080

agcaagtgtg ggatgggtct ttgcctttct gggtagggag ctgtctaatc caagtcccag     1140

gcttttggca gcttctctgc aacccaccgt gggtcctggt tgggagtggg gagggtcagg     1200

ttggggaaag atggggtaga gtgtagatgg cttggttcca gaggtgaggg ggccagggct     1260

gctgccatcc tggcctggtg gaggttgggg agctgtagga gagctagtga gtcgagactt     1320

agaagaatgg ggccacatag cagcagagga ctggtgtaag ggagggaggg gtagggacag     1380

aagctagacc caatctcctt tgggatgtgg gcagggaggg aagcaggctt ggagggttaa     1440

tttacccaca gaatgtgata gtaatagggg agggaggctg ctgtgggttt aactcctggg     1500

ttggctgttg ggtagacagg tggggaaaag gcccgtgagt cattgtaagc acaggtccaa     1560

cttggccctg actcctgcgg gggtatgggg aagctgtgac agaaacgatg ggtgctgtgg     1620

tcctctgcag gccctcaccc cttaacttcc tcatgcagac tggcactggg cagggcctct     1680

catgtggcag ccacatgtgg cgttgtgagg ccaccccatg tggggtctgt ggtgagagtc     1740

ctgtaggatc cctgctcaag cagcacagag gaaggggcaa gacgtggcct gtaggcactg     1800

tctcagcctg cagagaagaa agtgaggccg ggagcctgag cctgggctgg agccttctcc     1860

cctccccagt tggactaggg gcagtgttaa ttttgaaaag gtgtgggtcc ctgtgtcctt     1920

ttccaggggt ccaagggaac aggagaggtc actgggcctg ttttctccct cctgaccctg     1980

catctcccac cctgtgtatc atagggaact ttcaccttaa aatctttcta agcaaagtgt     2040

gaataggatt tttactccct ttgtacagta ttctgaggaa cgcaaataaa agggcaacat     2100

gtttctgtt                                                             2109


<210>  168
<211>  2125
<212>  DNA
<213>  Homo sapiens

<400>  168
cgacgacaag gatggggccc atctcttcgg agcctaagga tccagcccag gtccagccct       60

gcgcagccgc ccaccaagct gccagaagac gagccggacg cccaaggcta cgagaggacg      120

attgcagaat tgtacaggct agtggttggg gaatattttt tcgtggaagg gaccgtcttc      180

cttagctgtg gccctctcat caggtctggg aagaggtaat tggaaaatag aactcatgga      240

gaagtgttac cacaggccat ggacaaggcc agaatttccc tgacatctgt ccgccagcac      300

cgcccttcag gtacaattcc acaagagacc ccccaaactt gatgaagtca cccgcttaca      360

agggctcact ctccacctgc gcaaggactg caattcccag gggcctccag ggcacccggc      420

cgctccagtc cagtcgtgca ggcggcgcgc tctttctcgc tccgctcaag tccaggaacc      480

ggttcccggg ctcccagcct ctcggcagcg cccacgcgcc tgggccaaag tccgcgaacg      540

gaagccggcg gcgaggagga ttctgggagt tggaggccga ggctgcgacc tgcgcaggcg      600

caaacctgcc cctggggtga gggctgtaag tggcgcgatt cgcggcagcg ccccgatgga      660

acctcctggt cctgtgaggg ggcccttgca agattccagc tggtatgagc cttctgcaga      720

gctagtgcag actaggatgg ctgtatcact aacagcagct gaaactctgg cccttcaggg      780

tacacaggga caagagaaga tgatgatgat gggaccaaag gaagaggaac agtcttgtga      840

gtatgagacc aggctacctg ggaaccactc taccagtcaa gagatcttcc gccaacgctt      900

caggcatctc cgctaccagg agactcctgg tccccgggag gccttgagcc aactacgagt      960

actctgctgt gagtggctga ggccagagaa acacacgaag gagcagatcc tggagttcct     1020

ggtgctggaa caattcttga ccatcctgcc tgaggagctc caatcctggg tgcggggaca     1080

tcaccctaag agtggagagg aggctgtgac tgtgctggag gatttagaga aaggacttga     1140

accagagccg caggtcccag gccctgcaca tggacctgca caggaagagc catgggagaa     1200

gaaggaatct ctgggagcag cccaggaagc actgagcatc cagctccagc ctaaggagac     1260

ccagcctttc ccaaagagtg aacaggtata tttacatttt ctgtcagttg ttacagaaga     1320

tggcccagag cccaaggaca aaggatcatt gccacaacca cccattactg aagtggaatc     1380

acaggtgttc tcagaaaaac ttgctactga cacctctaca tttgaagcta cctctgaggg     1440

taccttagaa ctgcagcaga gaaatcccaa agcggagaga ctgaggtggt cccctgccca     1500

ggaggaaagt ttcaggcaga tggttgtcat ccataaggaa attcccacag ggaagaaaga     1560

ccatgaatgt agtgaatgtg gtaaaacctt catttataac tcacatcttg ttgtccacca     1620

gagagttcat tctggagaga aaccctataa gtgtagtgac tgtgggaaaa ctttcaaaca     1680

gagctcaaac ctcggtcagc atcagagaat tcatacagga gagaaaccct tcgaatgtaa     1740

tgaatgtggg aaggccttca gatggggtgc tcatcttgtt cagcatcaga ggattcactc     1800

aggagagaag ccctatgagt gtaatgagtg tgggaaggcc tttagtcaaa gctcatatct     1860

aagtcagcat cggagaattc acagtggaga gaaacctttt atatgtaaag aatgtgggaa     1920

agcttatgga tggtgctcag agctcattag acatcggaga gttcatgcca gaaaagagcc     1980

ttcccattga attgaagggg agaacgtctc cagacagaat tctacatcgg tctaatctac     2040

tttaggactg gatcccataa aagttataag ttccttaaaa aaaaaaaaaa aaaaaaaaaa     2100

aaaaaaaaaa aaaaaaaaaa aaaaa                                           2125


<210>  169
<211>  2125
<212>  DNA
<213>  Homo sapiens

<400>  169
caggactgct agcagtaaag atgggggagc cagggccccc atcccctcca gcccccaagg       60

ctgccccagg cctcattgac agcttctctg agatgaacaa ctaccggcgg gccatgcaga      120

agatggcaga ggacatcctg tctctgcgga gacaggccag catcctggaa ggagagaacc      180

gcatactgag gagccgcctg gcccagcagg aggaggaaga ggggcagggc aaagccagtg      240

aggcccagaa cacggtgtcc atgaagcaga aactgctgct gagtgagctg gatatgaaga      300

aactgaggga cagggtgcag catttgcaga atgagctgat tcgaaagaat gatcgagaga      360

aggagctgct ccttctgtat caggcccagc agccacaggc cgctctgctg aagcagtacc      420

agggcaagct gcagaagatg aaggcgctgg aggagactgt gcggcaccaa gagaaggtga      480

tcgagaagat ggagcgggtg ctggaggaca ggctgcagga caggagcaag ccccctcctc      540

tgaacaggca gcagggaaag ccctacacgg gcttccctat gctctcagcc tctggccttc      600

ccttgggttc tatgggagag aacctgccgg ttgaacttta ctcggtgctg ctggcagaaa      660

acgcgaagct gcggacggag ctggataaga accgccacca gcaggcccat cattctgcag      720

caacaggccc tgccggtgga ccccggggag ttgggagcag gaggagactt gacagagagg      780

ctacaagaga cgcatggccc aggccactca gagtgcacag agaccctgcc cgcacaggat      840

ctcctctctg gtacttcaga caagttcaac ctcctggcca agctggaaca cgctcagagc      900

cggatcctgt ccctggaaag ccagttagag gactcagctc gacgctgggg acgagagaag      960

caggatctgg ccacacggct gcaggagcaa gaaaaaggtt tcaggcaccc ctcgaactcc     1020

atcatcatag aacagcctgt gagtgacccc cctggagtag ctcccagggg ttcaggtggt     1080

ggagcaggaa gccaccgcac ccccaaagtc actgggccct gagaaaagcc attgtggagc     1140

caactccagg gctgggggtc aggagtccta ggctcccatt cctgctccat taccaaccga     1200

aggctcggtc ttaattcccc cacctgtcta aggggaacag aaaacccctg ccaaaactac     1260

cctttccccc atggggtgct gtgaaactca aggagatgac tgtggatgag gggtccatgc     1320

aggcatctcc aggatgccct gacactgtgc tttaggactg gctgcgctca tgggcagagt     1380

agcttgtggc cctacccccc tgaatccata gagcctaaga ttctcaaatt agcacaccct     1440

tctcagatgg ccacgatgta ggctccactt tgccaacttc ccgagaacaa acaggcctgc     1500

tcacaactgc ccctcaagtt caaccccggg accgcccagc cccgcaaagc aaagaccctg     1560

acttctcctg ctcttgagcc agctgtgctt tgcccgtggc cagaagctca gcagcggctc     1620

ctgggaaagg cctggaaagg atgagggaac aggcgaggaa caaaggcaac ctttgcacac     1680

tcacctgagc cctggggacc cttggagaaa ttaggtgtca cctgctgtgg caaaatgggt     1740

ttagaaatct ttgccaggtc atggcccact ggattctgga tactctgagg cctggtttgt     1800

caggcaatat gcccttgagc aggtcacccc ctgggaatgg ggggtactca cgcaccccgc     1860

tttgcacacc acagagtgcc ctcacccact ccatggacct caagcagccc tcagagctgg     1920

agcccctgct gcccagctca gactctaagc tcaacaagcc cttgagcccc cagaaggaga     1980

ccgctaactc tcagcagacc tgagccccag agcaggcctc cttccctgtg tgctggggag     2040

tctcatcacc gccccctaaa aatgacgtta ttaaatgttg tagctctgtg aaaaaaaaaa     2100

aaaaaaaaaa aaaaaaaaaa aaaaa                                           2125


<210>  170
<211>  520
<212>  DNA
<213>  Homo sapiens

<400>  170
gtctcccgcg aagaggagat ggcggagtcg ttgaggtctc cgcgccgctc cctgtacaaa       60

ctggtgggct cgccgccttg gaaagaggct ttccggcaga gatgcctgga gagaatgaga      120

aacagccggg acaggctcct aaacaggtac cgccaggctg gaagcagtgg gccagggaat      180

tctcagaaca gctttctagt tcaagaggtg atggaagaag agtggaatgc tttgcagtca      240

gtggagaatt gtccagaaga cttggctcag ctggaggagc tgatagacat ggctgtgctg      300

gaggaaattc aacaggagct gatcaaccaa ggcctgtgat acttgggctg tgatcctcta      360

gagccagctt ggactcacat cattctatgg ggttgaagac aactcattcc ctctgaggag      420

ccttgtacat acaagccttt tatttataac ttattttgta ttgaaacttt taaacaatac      480

tgaagaaaaa aaaacttttc cgacaaaaaa aaaaaaaaaa                            520


<210>  171
<211>  1561
<212>  DNA
<213>  Homo sapiens

<400>  171
cggccctgcg ccccagcccg gccgcggcac ctccgcctcg ccgccgctag gtcggccggc       60

tccgcccggc tgccgcctag gatgaatatc atggacttca acgtgaagaa gctggcggcc      120

gacgcaggca ccttcctcag tcgcgccgtg cagttcacag aagaaaagct tggccaggct      180

gagaagacag aattggatgc tcacttagag aacctcctta gcaaagctga atgtaccaaa      240

atatggacag aaaaaataat gaaacaaact gaagtgttat tgcagccaaa tccaaatgcc      300

aggatagaag aatttgttta tgagaaactg gatagaaaag ctccaagtcg tataaacaac      360

ccagaacttt tgggacaata tatgattgat gcagggactg agtttggccc aggaacagct      420

tatggtaatg cccttattaa atgtggagaa acccaaaaaa gaattggaac agcagacaga      480

gaactgattc aaacgtcagc cttaaatttt cttactcctt taagaaactt tatagaagga      540

gattacaaaa caattgctaa agaaaggaaa ctattgcaaa ataagagact ggatttggat      600

gctgcaaaaa cgagactaaa aaaggcaaaa gctgcagaaa ctagaaattc atctgaacag      660

gaattaagaa taactcaaag tgaatttgat cgtcaagcag agattaccag acttctgcta      720

gagggaatca gcagtacaca tgcccatcac cttcgctgtc tgaatgactt tgtagaagcc      780

cagatgactt actatgcaca gtgttaccag tatatgttgg acctccagaa acaactggga      840

agttttccat ccaattatct tagtaacaac aatcagactt ctgtgacacc tgtaccatca      900

gttttaccaa atgcgattgg ttcttctgcc atggcttcaa caagtggcct agtaatcacc      960

tctccttcca acctcagtga ccttaaggag tgtagtggca gcagaaaggc cagggttctc     1020

tatgattatg atgcagcaaa cagtactgaa ttatcacttc tggcagatga ggtgatcact     1080

gtgttcagtg ttgttggaat ggattcagac tggctaatgg gggaaagggg aaaccagaag     1140

ggcaaggtgc caattaccta cttagaactg ctcaattaag taggtggact atggaaaggt     1200

tgcccatcat gactttgtat ttatatacaa ttaactctaa ataaagcagg ttaagtatct     1260

tccatgttaa tgtgttaaga gactgaaaat accagccatc agaaactggc ctttctgcca     1320

ataaagttgc atggtaaata tttcattaca gaatttatgt tagagctttc atgccaagaa     1380

tgttttctta caaaattctc tttttattga ggtttcacta ataagcagct tctacttttg     1440

agcctcaact taaagcagaa ctgttttcta ctggattttt cattaacagc aagctttttc     1500

ttttatgtaa aataaatcta ttgtgaattg aaaaaaaaat aaaaagagaa ttttgtaaga     1560

a                                                                     1561


<210>  172
<211>  1127
<212>  DNA
<213>  Homo sapiens

<400>  172
gcagatcggc ttccggttcc ggtgggctct gaaccctgaa aggctcgcga tgcctctaca       60

caagtatccc gtgtggctct ggaagcggct gcagctgcgg gagggcatct gttcccgcct      120

gcccggccac tacctgcgct ccctggagga ggagcggacg cccactcccg tgcactatag      180

gcctcatggg gccaagttca agatcaaccc caagaacggg cagcgggagc gtgtggagga      240

cgtgcccatt cccatctact ttccccccga atcccagcgg gggttgtggg gcggcgaggg      300

ctggatcctg ggccaaatat atgccaacaa cgacaagctc tccaagaggc tgaagaaagt      360

gtggaagcca cagctgtttg agcgagagtt ctacagtgag atcctggaca agaagttcac      420

agtgactgtg accatgcgga ccctggacct catcgatgag gcttatgggc tcgactttta      480

catcctcaag accccgaagg aggacctgtg ctccaagttt gggatggacc tgaagcgagg      540

gatgctgctg cggcttgccc ggcaggaccc ccagctgcac cccgaggacc ccgagcggcg      600

ggcagccatc tacgacaagt acaaggaatt tgccatccca gaggaggagg cagagtgggt      660

gggcctcacg ctggaggagg ccattgagaa gcagagactt ttggaggaga aggaccctgt      720

acccctgttc aagatctatg tggcggagct gatccagcag ctgcagcagc aggcactgtc      780

agagccggcg gtggtgcaga agagagccag tggccagtga ccacacagct cctccatgcc      840

tgaccaacag gcccagcttt ccctgccagg ccctttgcac tgaggacaca gatcccgggg      900

agctgtgagg gccaccggtg ggcagtgggt ggatcctggt ttcgtgtgct gcccatgcac      960

cttccagccc ggggccagct tggcagggat ccccaggagg cctgggccgc ccagaggctc     1020

ctctcaggct gggccccgac gtttgcggca gtgttccttg tgcccgtggg gccgggagcg     1080

agtaaagtct gggccaggca aaaaaaaaaa aaaaaaaaaa aaaaaaa                   1127


<210>  173
<211>  1984
<212>  DNA
<213>  Homo sapiens

<400>  173
ggcgtagtgt gggtgactcc tccgttcctt gggtcccgtc gtctgtgata ctgcagcgca       60

gccatggcag aaccgcagcc cccgtccggc ggcctcacgg acgaggccgc cctcagttgc      120

tgctccgacg cggaccccag taccaaggat tttctattgc agcagaccat gctacgagtg      180

aaggatccta agaagtcact ggatttttat actagagttc ttggaatgac gctaatccaa      240

aaatgtgatt ttcccattat gaagttttca ctctacttct tggcttatga ggataaaaat      300

gacatcccta aagaaaaaga tgaaaaaata gcctgggcgc tctccagaaa agctacactt      360

gagctgacac acaattgggg cactgaagat gatgagaccc agagttacca caatggcaat      420

tcagaccctc gaggattcgg tcatattgga attgctgttc ctgatgtata cagtgcttgt      480

aaaaggtttg aagaactggg agtcaaattt gtgaagaaac ctgatgatgg taaaatgaaa      540

ggcctggcat ttattcaaga tcctgatggc tactggattg aaattttgaa tcctaacaaa      600

atggcaacct taatgtagtg ctgtgagaat tctcctttga gatttcagaa gaaaggaaac      660

aatgtgattc aagatattta cataccagaa gcatctagga ctgatggatc actgtcccga      720

ttcaaattat tcttcagtcc atttcccctt cctatttcag ctgttccttt tcacctaact      780

gttcagtcat tctggttttc aagcagtgct ttatctcatg tccttgaata tagttgtgta      840

actttatttt ttaggtaata attagaacag ttcccttcag aggctgcatt tgccttcttc      900

tgccacctaa atattacttc ccttcaaatc tgcctttgaa tcatcatttt taaaaaaaaa      960

ttaacatgtt tttgttgtag ttatcttctg gggtttcaat tcctcagaaa caactttttt     1020

cacaacggaa aggaaagaac actagtgttc tttcagtaaa gtacaaattg tttattttac     1080

aaaagagtag gtactcttga gagcaattca aatcatgctg acaaggatac tgatagaaaa     1140

agtgatttct tcttattata aagtacattt aaagttcaag gactaacctt atttatttgg     1200

gaaaggggag gaggaaggaa atgatatggt acccagacac tgggctaggc tgcaacttta     1260

tctcatttaa tactcccagc tgtcatgtga gaaagaaagc aggctaggca tgtgaaatca     1320

ctttcatgga ttattaatgg atttaagagg gcatcaatca gctcaactca agatttcata     1380

atcattttta gtatttagat tgtgcctcaa agttgtagta cctcacaata cctccactgg     1440

tttcctgttg taaaaacctt cagtgagttt gaccattgtg ctcttggctc ttgggctgga     1500

gtaccgtggt gagggagtaa acactagaag tctttagtac aaaactgctc tagggacacc     1560

tggtgattcc tacacaagtg atgtttatat ttctcataaa gagtcttccc tatcccaagg     1620

tcttcatgat gccagtagcc atatatgata aattatgttc agtgataact tagttatcag     1680

aaatcagctc agtggtcttc cccgccatga ttcacatttg atgagttttt aaaaatcaaa     1740

gtgattttga aaatctctaa tggctcagaa aataaaaaca tccagtttgt ggatgactat     1800

atttagattt ctctagactc tagtggaaga cctttggaaa ggccatgcca accgtgcttg     1860

tactgctaga agcactttat gtttcctttt tgggtgaaat ggatttatgt gagtgcttta     1920

aacaaatagc aatacttata gactgaaata aaatgaaact tcaaataaaa aaaaaaaaaa     1980

aaaa                                                                  1984


<210>  174
<211>  1520
<212>  DNA
<213>  Homo sapiens

<400>  174
ggcacgaggc cgagcctagt gcctcccacg cccggcggcc gcgagccggg gtccgcgagg       60

gcggagtggg gcgcggcagc caggaacccg actacgaatc ccagggtgcg ggcgggcgga      120

gcgaggaggg acgctgggcc tgcccggtgc gcacgggggc ggggaccggc aaggcgggac      180

catttcccgg cataggctcc ggtgcccctg cccggctccc gccgggaagt tctaggccgc      240

cgcacagaaa gccctgccct ccacgccggg tctctggagc gccctgggtt gcccggccgg      300

tccctgccgc tgacttgttg acactgcgag cactcagtcc ctcccgcgcg cctcctcccc      360

gcccgccccg ccgctcctcc tccctgtaac atgccatagt gcgcctgcga ccacacggcc      420

ggggcgctag cgttcgcctt cagccaccat ggggaatggg atgaacaaga tcctgcccgg      480

cctgtacatc ggcaacttca aagatgccag agacgcggaa caattgagca agaacaaggt      540

gacacatatt ctgtctgtcc atgatagtgc caggcctatg ttggagggag ttaaatacct      600

gtgcatccca gcagcggatt caccatctca aaacctgaca agacatttca aagaaagtat      660

taaattcatt cacgagtgcc ggctccgcgg tgagagctgc cttgtacact gcctggccgg      720

ggtctccagg agcgtgacac tggtgatcgc atacatcatg accgtcactg actttggctg      780

ggaggatgcc ctgcacaccg tgcgtgctgg gagatcctgt gccaacccca acgtgggctt      840

ccagagacag ctccaggagt ttgagaagca tgaggtccat cagtatcggc agtggctgaa      900

ggaagaatat ggagagagcc ctttgcagga tgcagaagaa gccaaaaaca ttctggccgc      960

tccaggaatt ctgaagttct gggcctttct cagaagactg taatgtacct gaagtttctg     1020

aaatattgca aacccacaga gtttaggctg gtgctgccaa aaagaaaagc aacatagagt     1080

ttaagtatcc agtagtgatt tgtaaacttg tttttcattt gaagctgaat atatacgtag     1140

tcatgtttat gttgagaact aaggatattc tttagcaaga gaaaatattt tccccttatc     1200

cccactgctg tggaggtttc tgtacctcgc ttggatgcct gtaaggatcc cgggagcctt     1260

gccgcactgc cttgtgggtg gcttggcgct cgtgattgct tcctgtgaac gcctcccaag     1320

gacgagccca gtgtagttgt gtggcgtgaa ctctgcccgt gtgttctcaa attccccagc     1380

ttgggaaata gcccttggtg tgggttttat ctctggtttg tgttctccgt ggtggaattg     1440

accgaaagct ctatgttttc gttaataaag ggcaacttag ccaagtttaa aaaaaaaaaa     1500

aaaaaaaaaa aaaaaaaaaa                                                 1520


<210>  175
<211>  2768
<212>  DNA
<213>  Homo sapiens

<400>  175
ggcctggccg gggcggcgca ctcaggtggc ctcgcttccc tgcgggtcac cgcccgccac       60

tcgcacagct aggtcggcct gttgggatcg ggagaggtgg gcgcacgagt tttagtgcgg      120

gagtccgggg tgcgggcgga gtcctattgt ccccgtgcac ccgggcggca gcacctccgg      180

gtccctcttt aaaccgagcg tccggcgacc tttctttgtg cttagggagt cgaaagcggc      240

atcttctccg agagaagtcg cctactgggg ggtggcgctg gggaggtaac aatgggcgcc      300

cattgtcctc cgagggtcca acggtgaccc cccccgctgc gcacgcgccc ggccaccggt      360

tggccccggg ccagggcaca ggtaccgcgg ccgggagggt cggccccgct gcccgcgccc      420

tccgccccgc cccagtgagt ccccgcgccg ccggccccgc cccgcgccgc cccgccctcc      480

gcaggttcag tcctcgcgtc cggccgcccc gcgctcagtc gcgcgcacct tctctcgcgg      540

ccgggggacc gcagcgcggg gctagcccgg agacccggcc accggcctgg ggcgccttca      600

cgccgtctcg gagcggataa tgcggtgagc aggcaccacg ccggcagact cggctggatc      660

tgcgcacagc ggcagggatt gcgtgcgccc gcgggaggcc cggggcagcg gctgggatcc      720

tcagcggcgg ccggtttgtc ctggttgtgg tcaagactgg atgatgtaac tggctctcta      780

ggaagcctca cttggccgta acctcaggaa ggttctcttt gaccccatct catttcgaag      840

ccacttctga agccacttga gaaaaatgat gtgacagttc ctatcaaaaa ggattcagaa      900

acatatacca tctgtgaaga aagtggccct ttctcccgct tgcaaaatag acattctcaa      960

attccaaaat gccagccaag accccaattt acctgaaagc agccaataac aagaaaggaa     1020

agaaatttaa actgagggac attctgtctc ctgatatgat cagtcccccg cttggagact     1080

ttcgccacac catccacatt ggcaaagagg gccagcacga tgtctttgga gatatttcct     1140

ttcttcaagg gaactacgag cttttacctg gaaaccagga gaaagcacac ctgggccagt     1200

tccctgggca taatgagttc ttccgggcca acagcacctc ggactctgtg ttcacagaaa     1260

cgccctcccc ggtgctcaaa aatgccatct ccctcccgac cattggagga tcccaagctc     1320

tcatgttgcc cttattgtca ccagtgacat ttaattccaa acaggagtcc ttcgggccag     1380

caaagctgcc caggcttagc tgcgagcccg tcatggagga aaaagctcag gagaaaagca     1440

gtctgttgga gaatgggaca gtccaccagg gagacacctc gtggggctcc agcggttctg     1500

catctcagtc cagccaaggc agagacagcc actcctccag cctgtccgaa cagtaccccg     1560

actggccagc cgaggacatg tttgaccatc ccaccccatg cgagctcatc aagggaaaga     1620

ctaagtcaga ggagtccctc tctgacctta caggttccct cctctccctg cagcttgatc     1680

ttgggccctc acttttggat gaggtgctga atgtaatgga taaaaataag taacaagatg     1740

ccaacttttt tcctttgggg taaaaggtac aaaaacaaac taaccacagt tgaagagaag     1800

ggcttccgga gctgtatttg cagttttgtg ttgggttttc taaaataata ttcttacaaa     1860

gtattttttt acctgttatg ccctgtttgc aaaaacaatt tagaaaaaaa caacaaagca     1920

aaacctatct tggcaaaaaa aggaagtgag tcagagccca ttttcaggag gcattggtga     1980

tgttcggctc acatattgtt tgcagacaca caagaaatct ggcttggcca ggattggcac     2040

tagctatgaa gggctgagcg agtcacatta aggaacttca cggaacttta tagcactccg     2100

acattttctg agcaagagga agtcaaaatt tatttaacac ctaagccttt ttgtagactc     2160

ttttctatat attgcttagg ctcaccatag cgaattctcc agtgttaaaa cttttctgtt     2220

ttcacatttg aactttatgg gttttgggga ttttcttgta gttcttatat atccctatat     2280

attatatcta tattgcaaaa ttttgactgt cagctacatg ttggtaagac acaggcaaag     2340

tattactgta actaagttat ttttaaagtt aaaatatatt tttacgtgcc tttggctttt     2400

tattgcagag tctacatttt atagattcta catcagatgt tgtcacttat ttccattggg     2460

attccattgt aagctgtgta tgtgcgtgtt tggaaaagtg tattcatact tagttttttt     2520

ttcttcatct gttatcatac ttttaacagc aaccaataac ggattgtaaa gtgtaaaggc     2580

acaggttact catgatgctt ctgcagagac tgtgggctac accacatatg ttatttggaa     2640

atataggtat tttagtacag tacatacttg cattacatag gtacttcaag caacacaata     2700

aaaagtaaat gataaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa     2760

aaaaaaag                                                              2768


<210>  176
<211>  10891
<212>  DNA
<213>  Homo sapiens

<400>  176
agccgctgag aggctctgcg tgtgcgtgtg cgcgggtgac gccgtgtgtg tgcgagtgtg       60

tgtgtgtgtg tgcgcgcgcg cgtgtgagag agagaaaggg agagagagag ggggactctg      120

tgtgagggaa agaaaacaat ttctcctgct ctgcagcttc tgttcaggat caatgtgact      180

ctaagaacaa atggatgaat gaatatccat atgaagagaa aaacaataaa gaatatcaac      240

acctttgaga acagaatgtt aatgcttgat gggatgccgg cagtcagagt caaaacagag      300

cttttggaat ctgaacaagg gtctccaaac gtccacaact atcccgatat ggaagccgtt      360

cccctgttgc taaataatgt gaaaggggag cccccggagg actcgttatc tgtagatcac      420

ttccaaacac aaactgagcc agtggacttg tcaataaaca aagccaggac gtcccctact      480

gccgtttcat cctccccagt ttccatgaca gcatctgcct cctcaccttc ttcaacttca      540

acctcttcat cgtcttctag tcgtctagcc tcatccccaa ctgttatcac atcagtatct      600

tcagcgtcat cttcgtcaac agtattaact ccagggcccc ttgtggcctc tgcatctggt      660

gttggaggcc agcagttttt gcacattatc catcccgtac cgccttcaag tcccatgaat      720

ttacagtcta acaaactgag tcatgttcac cgcatccccg tggtggtaca gtcggtgcct      780

gttgtctaca cagctgtaag gtcacctgga aatgtgaaca acactattgt cgtgccgctt      840

ttggaggatg ggagaggcca tggcaaagca caaatggacc cccgaggcct atctcccaga      900

caaagtaaaa gtgacagtga tgatgatgac ctgccaaatg tgaccttaga tagcgttaat      960

gaaactggat ctacggccct ttccatagcc agagcagtac aagaggtaca tccgtcccca     1020

gtatcaaggg tccggggcaa tcgaatgaat aatcaaaagt ttccttgttc aatttcacca     1080

tttagtattg agagcacaag acgccagaga cggtctgaat ccccagactc cagaaaacgg     1140

cgtatccaca gatgtgattt tgagggatgc aacaaagtgt acacaaaaag ttctcacctg     1200

aaggctcacc ggaggacaca tacaggagag aaaccttaca agtgtacctg ggaaggctgc     1260

acctggaagt tcgctcgttc agatgaactg acgaggcatt accgcaaaca tacgggagtg     1320

aagccattca agtgcgcgga ctgtgatcgc agcttttccc ggtcagatca tttggccctg     1380

caccgccgga ggcatatgtt ggtgtgagga atgctacctg tccagctgag cgtaagagct     1440

ggatctctta gcggcaccca attcagcagg gctgaatccc cttcacagtg ttaacacaaa     1500

agggcatcac catcccacga tgtctgaaac cagagcagga aaaagaaggc acacttcttt     1560

tggtctgaag gtaaccccca tcatgactag acgagaaccg tctttacccg gcctgggagc     1620

tcagtgacat aaatgctgaa gagacaggca ttgttttccg tgctgtgtcc tctgccattt     1680

aaagatgttt gtagcttgta cattttctga gctgtcagac attttgttat tgatacctta     1740

aaggtcacct accacaaatt gatggctaga gcaagacctt ttaaatttgg atgaatctcc     1800

catcatccca tcccttaacc cctttttaca gaaattttag ttacaatctg agtaagctag     1860

aacacacatc caatctgtta ccagcaagca gcatgaaagt agaaacgaag aagcagatgg     1920

agaggtccca ttacctgcaa agaaagggca ctcaggcagc cctttgcaat cgcgatggca     1980

gccactagat atcactctca acttgtcatt ctgccatgcc ctgaagaaaa ccaacattga     2040

atctttcatt tgtttgtcgt tgattgtttt tgttttgttt cgattctgtt ttgttcatct     2100

gttcgagcag aggggcagtt gaagtctcgt cctggtctct gccctggcat ggactggcac     2160

agaggtgttc tgtagttgaa taggaagagc ctgtctaaaa aactactgcc ccacttcaaa     2220

ttgcagtgtt ctgtcaccta ggcatcatct cttcctgccc ctagtatttg attacaagga     2280

accaggggaa aaaaactttc ttagacacac tggcaccaag gtaagaggtg gggctgccca     2340

ggcaaagtca gtgaacatga aaactcagac aaagcagaga tggaaataat gcgcctcttg     2400

aggagaaaag caataatgaa taaaaggact ttcctacaat aacttcactg aggactcacg     2460

ttaccaattt tcatacttac taaagggatt gtaaaaaaca ccccagcatt ttaggtgtct     2520

tggttccatt tacagcactg aggtaatctt tctgctgttt gttgtcctgc ttggttgagt     2580

accacaatta aagattatgc tccccttttc ttgtttgaaa acagttattt ggtgactaga     2640

aaggcaaggg aggcatagcc gggaattaac tcttcggtta atgggtcagt tctccttgga     2700

actgaatcag tggaaagaga atgcttccca tagaaagccc gacatggtgc tagtttcctc     2760

tcttggagag ccaaggataa gtgactctcc aataggttct tctataccga tttcattttc     2820

taaactgtat caggacccag gtgtcctgca ttggcatctg cagggatatt gaacccactc     2880

atcctgtgca gaggatgaga ggaaggtgtt agttccatca gccccataaa attatgaacc     2940

tttttgcaac taggaacata tacagtaaac aagcaataca tcaccaacga gcattctttc     3000

agaaaaatta ccatattttt gtccccacca caagctgggt ttttttccag ctttctgtgg     3060

ctgaggggct ggtgagattt tttgttgtta ttgttgttgt tgctagaatt ttttatagct     3120

tagatataaa aggtctccaa caaagacctt tgcaatatat tttaattaca aacacttgat     3180

tttgggaatt gcacatatta acctcacaat attactagct catttttaaa tgtctggaca     3240

ttctgaaata atttccggtt acagaattac cctttttagg atcatcttct aattcagata     3300

atcttattct gatgaagcga gaactatgaa cgttgaaaca aggacaattt gtgttggatg     3360

gtattcaaaa ggaatttttt aaaacattaa gcaacagtgt aatgattttc aggtcaaatt     3420

atggcttcac aaatatgtgc tctatattgt ctgccaggtc tcaaaaattc atcaagcaat     3480

ttccctccaa caagggctgc agttctagtg ataaatagca tctttagctg cacagtctac     3540

tactcatcaa ccagtgggtt ttttttagca cctggaaagt ttttttgtac tatatgcaac     3600

tcctacttca cattgcctgt gaccattcag aatagaaaaa ggtctgttga tgcatgccag     3660

tgctggttac tagtcagtga cagagaacac agagagggac aaacacagcc atgaaccccc     3720

tggcactagt accagcacct agttggcaag tagtgggtgc atctctcaag tgaagtgtag     3780

atttgtattt agtcctgctt gctctcataa aaagagccag ttcttttctc tgctgaaaga     3840

tgtcttgaga gtattacagg tagacttggt ttttagaatt cataaaactg acaggcaggg     3900

gaatcttcct gagtgacagc ttggtttaaa tttagcacag aactagatga gttgcacttt     3960

tctaataaca taggatggat ttggggaagg gaacattttc cctcatcctc tgaaagtgga     4020

aaccagactg agatggtaag ttaactgata aaacctgtca gcattccatc attttcccct     4080

tttgacgtat cagtacttct aagaagggat ctaagcacaa ttaagtgaat tgagtccctg     4140

gtctagcctc aggaactgaa acttctttgg ggcttgtctt gagacgtggc aaattctcct     4200

tggtgagttt tctaaaagta tttccccatg gaaaggagaa agtggtttgg gacagaaaga     4260

aatggaatgt cttcagtcat ggaagagcct ccatttcatc tcatgtccat ttctagcctc     4320

tttcaaaaag cacagtgcat catgagcaac agaaaagcag tagaatccta aaggacataa     4380

cagttgttcc gtaactagaa gcattctttg attttaaatt tgaagctgtt cagtttgcag     4440

ctggggatat gtgcatggtt gggaacttat acacatagag ccattaacta cttaagcagc     4500

tgcagtagac ctgattttct gtttgcagta tagagattga tttcaaggga gttacattat     4560

ttgaaaagtt atgactttca gcctttgagg ttttaagaat cccttttcat ggtctgatct     4620

taagttgttt gaaaaaagat tcacgcttct gcatccacct ctgccctcat tctgtcaatt     4680

gtgtgtggac tctgagaagc ctgcttgata acttgtctta agttctatta aggcagttag     4740

actgagattt ctaatgactt caccataaag attatacttc tgcctggcgt cgtttctata     4800

aaacactata ggacatttgt tttcaaaagc agttgagtaa cagcaacata aaccacattt     4860

tttaaaaaaa tgagcacttt tcattcactt gaaagcttaa gtgggaaaaa ggaagatgat     4920

tgtcagggga aaaacttaca aaatgctaca gtgtttacaa atgccagttc caggtgatta     4980

gaaaggccgt tttcattatg gttcagattt ggaatagctt atgcaaagat tgtgttcatt     5040

tttatacaat tctttttaac tttaaattgc catctgtgtt ttaaacataa ttctgcactt     5100

tggaatcagt tcattagaat gataacattt atatggataa agatgcagta ttccttattc     5160

tgtacttgat ttattatact taccaaagct gcaactgaat aaatctggtg aggtgaggcc     5220

ttcaaaatgt attaatacgc ctttgttatg ttgttatgac tgcttagaaa tgtagccatg     5280

atgttgttct aaagatgtct taacatttat agtgaggatt gacagaaatt aagcagtgtt     5340

aagaatacca gcatccatgt tacagtctgc gtataaggga ctgaatgtga ggtaactctt     5400

atgaatcata ataggcccag aaagccttaa tattcatagt tcataatcca gtctcagatt     5460

ttgctcttca atgttgcctg taaacttagc aggtaaatgt attctagtat aaaacatcat     5520

tgaccaaatc tcttccttta gtttttctga ggtagtgcat cccattaaaa aagtctcttc     5580

aattagattt ggctttagtt tagaaagggg tttggtaagt catgtcttcc atatgacatt     5640

tctactcatc cccacactgc cttccactta acctgtacag acagccccaa cacatgcaca     5700

tgtgtgtaca caactgtata tgcagcagcc agtgggctaa caaatatcag caaagaactt     5760

ttttaaaaag aatttgtaat aatccgtgct gtctagaaat gtgagttact taccttatta     5820

ggaaaccggc ttataatact atatatgact ctgcctgcat tttatagtta agaaatgtac     5880

ataaaaattg ctatattttc acagtttcat tataatgtct gtttagtaac ccatgtccac     5940

tgatacttta aatatgctaa ttactgagca attgcaatag aaatccagat tttcataaga     6000

aaatgaaata gaaggatact gcatctttaa aaaatagagt gaagatattt tactgtattc     6060

gtaacatatg tgatagtgga aaaagtattt tcaaactcac aaattttaca gaggttgtaa     6120

atagtttgat gaagtatgtt gggaaagaga gcttctagtt ttcatcacaa taaaaagaaa     6180

aaacttgttc agatatgcct tgtatatctt acacacaatg agtgaaattg ccatgggaac     6240

tctgtccaac tttgtcagag catgctcttc gtgttctgtt caaaatagag tggccacttg     6300

tcatggttta gccaggatgg tttaaaatat aatgaagtca ttttaagttg cagacaactg     6360

attccaaact agtaatgtct tttcctgaaa agggcaaaac agctgcacag gattttgctt     6420

gtactaaaga ggagcatctt acaattgttc tcttttctca gttatctccc tcctcaacag     6480

agtgtgaaca accatacagg tgtttattct tgttttattc cagggagact gcttttaggt     6540

ataactacat gttgacaaga ttaagtgctg tggatatggc cacgtgttaa aggaatctat     6600

actcgcaata ggaataagct aatgcccatt ttcagaaata aattaaatgc tgaaagtgcc     6660

tgtcagtaaa ccttatgacc aatgagatat tcctatactt ttacacagca ataattctta     6720

ataagactgg gttttttcct gcacatgtga acacacacac acatacacac agagagagta     6780

aatacataca catagtaaat caaatctgtt cacatgccca caaaaaacgc ttttatagct     6840

ttcaaatata cctaatcttg tttacattaa catttcttaa tttgatcttt ctaacttgca     6900

gaacgttaag aacacaaatc tgaacattaa gtttatcttc agtgaacact attgcatatg     6960

gtaattataa tttccagata aaaagttgac tgtcatttgc cccaaactta tgaaacagta     7020

tgtatgattc aaaaagtttt gctcagttaa aaacaccaat ttatttggcg caaaagactg     7080

aaggatattt gtttgcttgt tcattttatc cactcatatc aaacgcacaa attcatcttt     7140

acatttcttc attccccttt cccctaatat ttcctattat catcttaaga atcattttgg     7200

aatgaatatt gacagaatca tttctcccca aaaagtctgt tgaagtacca ctgacactta     7260

gtaagcctag cctttaacca tctttgcagt tagtcctaaa aattaccaga tgcacattca     7320

gaagctcaca ggttttttcc tgtaattact gtactgctaa aagtggagtc atggatagaa     7380

atatacaatg agactatatg aatagacatg aaccctggaa attctccaac cctgccatct     7440

cagagcacaa attcacccaa acaagctact gaggctatca gtaaaattat actcatggag     7500

agtcacacat cgggtaaggg caattttaaa agtaggactg tgattaaaca ttcaggcttt     7560

agacttccat gatggactca gaccacaggc ctcaaaaaaa catccactgt tttctcctcc     7620

caatgttaga aagaagaaaa gggagacgga aatgtaccag gataaggggg taaaataacc     7680

aattaagtgt caaaggaaag ctgctgggtt ccttaatctc actgaagtca agtcttctga     7740

ctgggcttct taccatgtgt tgtctgaaaa aactaaagta ccttgaaagg ttacacattc     7800

agcaaaccat gaagataata gctattcttt attaaacact gtgtgccaag caatagacta     7860

ggcaattttt agatacgtta cctgcaacct gtacaacatt tctacacttt atggatggga     7920

aacggagaca tgggaagtgt ggctgagttg ttcatggatg tagaaatagt aaacggcaga     7980

gtaggaaagt gaaaccgcct atctctgacc tggaggtctg cctgtatctt tcccactcca     8040

ccacactgca cgtgggtgtc ccgaaaccac cttcccagat tcctgactct cagtaatttt     8100

attatggaca acatgcatga gtagtcatca tatttttcaa gtgaaatatc gggacatgat     8160

ataacacatg acttaacaat ggtactgaat atttgaaatc aggcctttcc cggaaaatca     8220

tgcatgaagg atcattataa acaaacaata gcaaccagtt gtctccccga acttgtcact     8280

tttctcataa atgtctggcc tggagctcca aaatcatcca aatacttagt agcattttag     8340

cctgagtaca ctttctcagt tcctcaactc tttgtatacc tttccaccaa tatagacatt     8400

ctagaatctg cttcagatgc atttgaaatt ttcaccccca tggaactagt gattaatatc     8460

agagcccact cttgcagttg gtaatggggt ggcaatcaaa cgttcagatg atgataaagg     8520

agagataatg gataattctt tttcagagtt ctcacttaac agctctgttg tggaatgttt     8580

taaatagtct tataaataat ttgtttatag tattgttgtt agtttaattg aattttatgt     8640

aagaagctgt ccaacatcag agaaatgaaa ttcctcccac tttctgtgta gaacaaggtc     8700

tctgacagta ttgattcatg gaagtactaa tggacttaga aaacattaag agaatgtcat     8760

ttctcatagt gtttctgttt ctgaaaatga atctcctgaa ttattatctt tctccctgtt     8820

acttggctgg ggaaagagat agaagctgta taaacaaatt ctcttccatg ctcaaagcaa     8880

gtgttccatg tgcacaacct gctgcagact ggggcccttc tcagttaatt gggtttcaca     8940

agcaataatt tctccacaac aaaaaccaca acttgaagtg agttgaaaag agatcaatag     9000

tggaaacagt cgcctcagta ctttttcttt ctggatttca tctctagaaa tttgaagtgt     9060

ttgagacaga gtccaccctt tgtgcaaggc gagaaccaat gaatggactc cttgtgtgaa     9120

ttattgcatc ttcttccaaa gcaggttcat caagactttc acagagattc atttttgttg     9180

agaagtaagg gttaatagga ggatagaatt tggatccaaa tctagtgata aaagtgtcca     9240

agcaatcaaa aagtaagata ttttagggac ataccaacat cttccctttc tgctaatttc     9300

atgctccaaa gatatggcaa aaaaaaaaat cataaaaagt gcttttgccc tacttgtgtt     9360

ctagttttcc catggcagaa ttttgtaatt acatccagaa tatagtgtat attttgttcc     9420

tcaaacttta ttacattgga tggatattgt tgaactgggg cactggtgcc tatattcaag     9480

gctctttcct atcaacgtgt ctgtccacga tttgttgtgt ttaaagcttc attttgaaaa     9540

atcactgtcc ccctgtgggg tagtgactgt attgttttgt tcatgtctat gtgggacaca     9600

ttgcatcaca tggcaaacca actctctgtg gatgtgagat aagtacttat aaaaccagct     9660

tgaaaacatc gtcttatgta ttatgtcatc ctgcatcata atgcaattat gtgtatcata     9720

acatgctcat ttaaaaaaag agaaaccagc aaattcatgt ttgtccatag aagaatgtac     9780

tcagaacttt gtgttgtgaa acgatgagaa cagaccacct ttaagatacc cacctgccac     9840

ttaaaatgac ttagttataa ttagtagtag tctagacgtt gttcttggtg tgtgggggtc     9900

aattctaacg tcatgttctt ttgaataaat ctctcagtca tatttgaaaa aaaaatacat     9960

gggaataaag aaaaatatca tctttggcca aatcaagcag gcatcttttt tcttttcctt    10020

gacgtttagc tcattatacg tggtgattgg atcacgagat ctgtccgtgt gaaaatacag    10080

aaacatcctt tagtttacaa aacagttatt ctaggcttga agcctctgaa cagcaaattg    10140

aatagatggg ctgcatctga tttgctttat ggatgtaatt ttacaaaaca ctcttgggtc    10200

tctgacccca gggagttaag agtgcccaga ggaggtccta cacattaaag gataaagccc    10260

cccagtgatg ctggcaagca aatgtgttga gttcttaaat cttcatttgg ttttctgttc    10320

aggattttaa ttgcaaatga atttatttct ccagtttatc taaagaccta atttcccaat    10380

agtttcctct gcatttatat actctgtagt gtttaggcaa ccctgttata agtttattaa    10440

tattatgtaa gtgttgttct tgtatttatg tatagtgtat gtattgtaaa tatactcaga    10500

gcttttttcc ttttactgta aaatggtgat ttttttgccc tatgataatg taaagggaga    10560

ccctcctaat gagattctct cagaggatga ttattccagt ctattctcag agatttaaat    10620

gaacaagtgt tattgttttt aatggtgtct cagacatatt ctgttggtgc attgcttttc    10680

tgtattcaac tttcctatga attgagctgt gaactgaaat agagtttaaa cctttaactg    10740

tatgcatttg tataattatc tgaatgaagg catgaaggtt aaataaagca ttttgtatgg    10800

aacaaaaaac aaaactccct aactgactca gacactttgg aaatcatagt tattaaccat    10860

tctaattaaa cctttgttat gaaaagtttt a                                   10891


<210>  177
<211>  684
<212>  DNA
<213>  Homo sapiens

<400>  177
cattcccagc ctcacatcac tcacaccttg catttcaccc ctgcatccca gtcgccctgc       60

agcctcacac agatcctgca cacacccaga cagctggcgc tcacacattc accgttggcc      120

tgcctctgtt caccctccat ggccctgcta ctggccctca gcctgctggt tctctggact      180

tccccagccc caactctgag tggcaccaat gatgctgaag actgctgcct gtctgtgacc      240

cagaaaccca tccctgggta catcgtgagg aacttccact accttctcat caaggatggc      300

tgcagggtgc ctgctgtagt gttcaccaca ctgaggggcc gccagctctg tgcaccccca      360

gaccagccct gggtagaacg catcatccag agactgcaga ggacctcagc caagatgaag      420

cgccgcagca gttaacctat gaccgtgcag agggagcccg gagtccgagt caagcattgt      480

gaattattac ctaacctggg gaaccgagga ccagaaggaa ggaccaggct tccagctcct      540

ctgcaccaga cctgaccagc caggacaggg cctggggtgt gtgtgagtgt gagtgtgagc      600

gagagggtga gtgtggtcag agtaaagctg ctccaccccc agattgcaat gctaccaata      660

aagccgcctg gtgtttacaa ctaa                                             684


<210>  178
<211>  4718
<212>  DNA
<213>  Homo sapiens

<400>  178
gtccctcgcg gagcttactg agcgcggccg ccgagcccag ctccgccgcc gagcgcctgt       60

gccggcacgg ctacaccatg gagcgcccgg ataaggcggc gctgaacgca ctgcagcctc      120

ctgagttcag aaatgaaagc tcattagcat ctacactgaa gacgctcctg ttcttcacag      180

ctttaatgat cactgttcct attgggttat atttcacaac taaatcttac atatttgaag      240

gcgcccttgg gatgtccaat agggacagct atttttacgc tgctattgtt gcagtggtcg      300

ccgtccatgt ggtgctggcc ctctttgtgt atgtggcctg gaatgaaggc tcacgacagt      360

ggcgtgaagg caaacaggat taaagtgaac atcacctttt tatagcatta aattcatttt      420

ttaaaatgat aaatgctgga gggggccatc tgatttgaat aaagtcgaaa gaacatgtta      480

aagtcagtct taaggagtca cgtttgagta tgtaaatttt gatctttcta atatgttggt      540

ttgtatattc agttttaact gtatgaatct gatttgcaaa tgagaatttg gaaaagttag      600

ttacaaagaa atatgttaat ttaattagac aatactctgg aaggaatttt atcttctttc      660

aacaaaacat gttttatagt attctgactt acggttgctt ttgagtttta ctcatttgga      720

tatattaaga tgcacacagt gaagcaaatt aaactccact ttacgctgga atgctttctt      780

tagcatgaaa ataccaggtc cttggatttg ggattttaat ttcctatgga aagttgctta      840

aattgtggac actggaatta atctgaatgt cactgaggaa tttcacatga agtgtaatcc      900

ctagtcaata agaattatcc attacattat tttatgggaa aactaggcta aattacatcc      960

attcaggtaa aaggacctta gcttactgaa ggatctaaag agcaaagcaa agatctcact     1020

actcaaacac tcagcctgct tccttcgagc ccccttgcag gccagctttg tgctttgcag     1080

accaactttt taatgagata ctttgcttcc tcattcaaca ttgaagctag gcttcaatta     1140

aaaggttcga ggaagctcca tttaaaattg ttttttttac tattttttaa aattgtagtg     1200

tatatgatag gaatttgcat ttaaatatgt tcatttttgc atatgttagg agtggaaaca     1260

atctggaaaa catttttttt tcatccaaaa agtattctcc ttgggcatat ctgatggaaa     1320

aaaaccttga ttttattttc gtatctttag tctgtgttct ttctagttat ttggtactaa     1380

ttatgtgcaa tctaaaaaca ctcccacaag tatttgtttt ttaattataa aatcatagta     1440

catgttcttt gtagaaaact ggaaaaatac atattcaaac aggaaaaaaa atcaaaattc     1500

cccataatgt tgccatctaa aaataacctc tattttagtt gatatcccgt attcattttt     1560

gaaagccatt ccttaatgct agtttgatac acactaaaag tttagcttac aagttcaaat     1620

tctgccagct tttcctgaca gctatttgca tttttttcag atgagtgatt attggccatt     1680

ttctttttct ttttctttat tttatttatt tatttttttg agacagagtt ttgctctgtt     1740

gcccaggctg gagtgcagtg gtgcaatctc ggctcactgc aacctctgcc tcctgggttc     1800

aagtgattct ccacctcagc ctcccaagta gctgggacta cggatgcctg ccaccacgcc     1860

tggctaattt ttttttgtat ttttttgtag agacggggtt tcaccatgtt gtccaggcta     1920

atcttgaact tgtgacctca ggtgatccac ccgcctcggc ctccgaaagt gctgggatta     1980

caggcgtgag ctaccacgcc cggccttatt gaccattttc taaataagca cattctatct     2040

ttattctctt aaaattcaaa ttttctgtta ctgataatcc taatactagg attcttgctt     2100

aagtatgtga aaccattacc gatttgttgt tcacatttat tttttatgtt gtgaaactgg     2160

actaaaggaa tagagggatg attagtcata aaagtcaaat agcatttgtg tttaactgtt     2220

gagaaaagtg aaagatcagt gtgattatta tggaactgtt tttaattctt gcttaaagac     2280

tacaatttta gtataatgac atttgagtct agggtagtat gtggtagatt tctagatggt     2340

ccctaattaa gaagtattgt tgtatttaga attgtccacc taatttcttt ttatataatg     2400

ccaaggtatt tcttgtgctt ttgggatctt atgctgtttg taaaatgtta ctgtccaatg     2460

ttggattatt gttttggttt caggcatttg ctgaataggt gatgatacat gggtattttt     2520

ctgcaagtat ttaaaccagg ggcatatgca aaggcagttg taatttcctc ttggaaaaag     2580

cgccaaatgt ttgaaggtta aaatcaaatg ctagggttga tatttaggct tataacaaaa     2640

taggcttgtt ttcaaagcag ttttttccta gagttttaac tgttaactca ctagtttgct     2700

gctgttttta actatgttaa ataacatatg gtatttggca aatagattta tttttcaaaa     2760

tgtctcacta gtttcctttt acacaatgta tatacttcaa gatgtataga aaggaaagct     2820

acagctgagc ccttatacat gttttaaggt agaaatatgt tccctattgt ttgaaaactg     2880

attgtaagaa taacctcagt taggagatat aacttgaagt gtcagtccaa actactgatt     2940

taaccctatt tacggtaaca cattaccttc ctcacctcct gtttggccct ggagaatgta     3000

gtcctttttc tcatttgtgt tgagaaatga aaagtctgct gtagaatgta tctgatgtca     3060

ttagttcttc aaatggatac cattgtacat ataacagtag aatttggttt ggggttgtta     3120

gtgaaaaaaa atttaaacct gccattaaaa atccccatgt ttcatggaaa tctaacagaa     3180

atacattgta ataattagaa cattttgttt tcttttttct tttttttttt ttcgagacgg     3240

agttttgccc ttcttgccca ggctggagtg caagggcgca atctcggctc gctgcaacct     3300

ccgcctcccg ggttcaagca gttctcctgc ctcagccccc tgagtacctc agatgacagg     3360

tgcgtgccac cacacccggc taatttttgt atttttagta gagacggggt ttcaccatgt     3420

tagccaggct agtctcgaac tcctgacctc aggtgatcca cccgcctccg cctcccaaag     3480

tgctgggatt acaggtatca gccaccgtgc ctggcctaat aattggaaca ttttcatcat     3540

gaaaatgtca tcagctttgc caaaagaaac aaccaattga cttgtttggc gtttgttttc     3600

cattttcatg tcaattttat gtatacagtt agaataccca aggagaccac taaaatcagt     3660

taaacaagta gggtatatac aaagaaaggt gaaacccgaa agtacataaa aaggatttaa     3720

atccgatttt agatgtacct agtgtgtatt tcttatctct agacaagttc atgtttattg     3780

tttaatttat gcccaagtga agttgtaaac ttatggttca actctgacac agaatttgtc     3840

acttgtctga ggtcagtggc aggtttctct gctgtcaagc actctgtgtc acccaccaga     3900

ttagtataac tattaattca gactgtactc ctatgtttaa gataattttt acaagagctg     3960

gctgaagcag cacattagta acctgacaag atttcttttt cccttttcag ggggaaaggg     4020

tcaccttaaa aataaattat tttcagggac tttgggaatc taatgataaa tattacacat     4080

aatctatgaa tagcttaatc ctttatatat tccttaaaat aggaattcct cgacatcact     4140

cctggccaca ctttccttgc ctgtgttgtt gctatgtgta tttgaaagta atatctgcat     4200

tccttttaag atgttctgta agtcatattt gtcagttata cagagtagtc ttccttttcc     4260

ccacgttcag tgtaatctca ctgaacagta ataatagcaa tagctaacaa catctgcaca     4320

gcaccttaca gtttgcaaag aacgttcaca cattctcatt tgagttttgc atagtgaacc     4380

tgttacgaga tgtctcttga cgtcgatgct aaaagtgtta gaatctttac atcactagag     4440

tcattgaata tgctgtagta ttgaatagtg ccctgactag ggggaggatt tggatgtgct     4500

gcatttcaag ccgtgtataa tcatcaaaat ggggggcttg agttccttag ctacttgaat     4560

ccgatttact tctgttaagt gatgcttttc taaccgtttt ctggatggat tttgtattca     4620

ctatattgta gcttgtaatt tgtataaatg taccatctga tgtcattaaa aaaagtgttt     4680

gtagtgctaa aaaaaaaaaa aaaaaaaaaa aaaaaaaa                             4718


<210>  179
<211>  1156
<212>  DNA
<213>  Homo sapiens

<400>  179
ggcacggggg caacccgagc cgcacccgcc gcggacggag cccatgcgcg gggcgaaccg       60

cgcgcccccg cccccgcccc gccccggcct cggccccggc cctggccccg ggggcagtcg      120

cgcctgtgaa cggtggggca ggagaccctg taggaggacc ccgggccgca ggcccctgag      180

gagcgatgac ggaatataag ctggtggtgg tgggcgccgg cggtgtgggc aagagtgcgc      240

tgaccatcca gctgatccag aaccattttg tggacgaata cgaccccact atagaggatt      300

cctaccggaa gcaggtggtc attgatgggg agacgtgcct gttggacatc ctggataccg      360

ccggccagga ggagtacagc gccatgcggg accagtacat gcgcaccggg gagggcttcc      420

tgtgtgtgtt tgccatcaac aacaccaagt cttttgagga catccaccag tacagggagc      480

agatcaaacg ggtgaaggac tcggatgacg tgcccatggt gctggtgggg aacaagtgtg      540

acctggctgc acgcactgtg gaatctcggc aggctcagga cctcgcccga agctacggca      600

tcccctacat cgagacctcg gccaagaccc ggcagggcag ccgctctggc tctagctcca      660

gctccgggac cctctgggac cccccgggac ccatgtgacc cagcggcccc tcgcgctgga      720

gtggaggatg ccttctacac gttggtgcgt gagatccggc agcacaagct gcggaagctg      780

aaccctcctg atgagagtgg ccccggctgc atgagctgca agtgtgtgct ctcctgacgc      840

agcacaagct caggacatgg aggtgccgga tgcaggaagg aggtgcagac ggaaggagga      900

ggaaggaagg acggaagcaa ggaaggaagg aagggctgct ggagcccagt caccccggga      960

ccgtgggccg aggtgactgc agaccctccc agggaggctg tgcacagact gtcttgaaca     1020

tcccaaatgc caccggaacc ccagccctta gctcccctcc caggcctctg tgggcccttg     1080

tcgggcacag atgggatcac agtaaattat tggatggtct tgaaaaaaaa aaaaaaaaaa     1140

aaaaaaaaaa aaaaaa                                                     1156


<210>  180
<211>  1110
<212>  DNA
<213>  Homo sapiens

<400>  180
gcaagcgcag attgtgggcg gctgtgtcag ctgacccaag gggccttcga ggtgccttag       60

gccgcttgcc ttgctctcag aatcgctgcc gccatggcta gtcagtctca ggggattcag      120

cagctgctgc aggccgagaa gcgggcagcc gagaaggtgt ccgaggcccg caaaagaaag      180

aaccggaggc tgaagcaggc caaagaagaa gctcaggctg aaattgaaca gtaccgcctg      240

cagagggaga aagaattcaa ggccaaggaa gctgcggcat tgggatcccg tggcagttgc      300

agcactgaag tggagaagga gacccaggag aagatgacca tcctccagac atacttccgg      360

cagaacaggg atgaagtctt ggacaacctc ttggcttttg tctgtgacat tcggccagaa      420

atccatgaaa actaccgcat aaatggatag aagagagaag cacctgtgct gtggagtggc      480

attttagatg ccctcacgaa tatgaagctt agcacagctc tagttacatt cttatgatat      540

ggcattaaat tatttccata tattatataa taggtccttc cactttttgg agagtagcaa      600

atctagcttt tttgtacaga cttagaaatt atctaaagat ttcatctttt tacctcatat      660

ttcttaggaa tttaatggtt atatgttgtc tttttttcct atgtcttttg gctcaagcaa      720

catgtatatc agtgttgact ttttctttct tagatctagt ttaaaaaaaa aaaaaaccac      780

ataacaattc tttgaagaaa ggaagggatt aaataatttt tttccctaac actttcttga      840

aggtcagggg ctttatctat gaaaaagtag taaatagttc tttgtaacct gtgtgaagca      900

gcagccagcc ttaaagtagt ccattcttgc taatggttag aacagtgaat actagtggaa      960

ttgtttgggc tgcttttagt ttctcttaat caaaattact agatgataga attcaagaac     1020

ttgttacatg tattacttgg tgtatcgata atcatttaaa agtaaagact ctgtcatgca     1080

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa                                      1110


<210>  181
<211>  5384
<212>  DNA
<213>  Homo sapiens

<400>  181
aaaatgttgg agatctgcct gaagctggtg ggctgcaaat ccaagaaggg gctgtcctcg       60

tcctccagct gttatctgga agaagccctt cagcggccag tagcatctga ctttgagcct      120

cagggtctga gtgaagccgc tcgttggaac tccaaggaaa accttctcgc tggacccagt      180

gaaaatgacc ccaacctttt cgttgcactg tatgattttg tggccagtgg agataacact      240

ctaagcataa ctaaaggtga aaagctccgg gtcttaggct ataatcacaa tggggaatgg      300

tgtgaagccc aaaccaaaaa tggccaaggc tgggtcccaa gcaactacat cacgccagtc      360

aacagtctgg agaaacactc ctggtaccat gggcctgtgt cccgcaatgc cgctgagtat      420

ctgctgagca gcgggatcaa tggcagcttc ttggtgcgtg agagtgagag cagtcctggc      480

cagaggtcca tctcgctgag atacgaaggg agggtgtacc attacaggat caacactgct      540

tctgatggca agctctacgt ctcctccgag agccgcttca acaccctggc cgagttggtt      600

catcatcatt caacggtggc cgacgggctc atcaccacgc tccattatcc agccccaaag      660

cgcaacaagc ccactgtcta tggtgtgtcc cccaactacg acaagtggga gatggaacgc      720

acggacatca ccatgaagca caagctgggc gggggccagt acggggaggt gtacgagggc      780

gtgtggaaga aatacagcct gacggtggcc gtgaagacct tgaaggagga caccatggag      840

gtggaagagt tcttgaaaga agctgcagtc atgaaagaga tcaaacaccc taacctggtg      900

cagctccttg gggtctgcac ccgggagccc ccgttctata tcatcactga gttcatgacc      960

tacgggaacc tcctggacta cctgagggag tgcaaccggc aggaggtgaa cgccgtggtg     1020

ctgctgtaca tggccactca gatctcgtca gccatggagt acctggagaa gaaaaacttc     1080

atccacagag atcttgctgc ccgaaactgc ctggtagggg agaaccactt ggtgaaggta     1140

gctgattttg gcctgagcag gttgatgaca ggggacacct acacagccca tgctggagcc     1200

aagttcccca tcaaatggac tgcacccgag agcctggcct acaacaagtt ctccatcaag     1260

tccgacgtct gggcatttgg agtattgctt tgggaaattg ctacctatgg catgtcccct     1320

tacccgggaa ttgacctgtc ccaggtgtat gagctgctag agaaggacta ccgcatggag     1380

cgcccagaag gctgcccaga gaaggtctat gaactcatgc gagcatgttg gcagtggaat     1440

ccctctgacc ggccctcctt tgctgaaatc caccaagcct ttgaaacaat gttccaggaa     1500

tccagtatct cagacgaagt ggaaaaggag ctggggaaac aaggcgtccg tggggctgtg     1560

agtaccttgc tgcaggcccc agagctgccc accaagacga ggacctccag gagagctgca     1620

gagcacagag acaccactga cgtgcctgag atgcctcact ccaagggcca gggagagagc     1680

gatcctctgg accatgagcc tgccgtgtct ccattgctcc ctcgaaaaga gcgaggtccc     1740

ccggagggcg gcctgaatga agatgagcgc cttctcccca aagacaaaaa gaccaacttg     1800

ttcagcgcct tgatcaagaa gaagaagaag acagccccaa cccctcccaa acgcagcagc     1860

tccttccggg agatggacgg ccagccggag cgcagagggg ccggcgagga agagggccga     1920

gacatcagca acggggcact ggctttcacc cccttggaca cagctgaccc agccaagtcc     1980

ccaaagccca gcaatggggc tggggtcccc aatggagccc tccgggagtc cgggggctca     2040

ggcttccggt ctccccacct gtggaagaag tccagcacgc tgaccagcag ccgcctagcc     2100

accggcgagg aggagggcgg tggcagctcc agcaagcgct tcctgcgctc ttgctccgcc     2160

tcctgcgttc cccatggggc caaggacacg gagtggaggt cagtcacgct gcctcgggac     2220

ttgcagtcca cgggaagaca gtttgactcg tccacatttg gagggcacaa aagtgagaag     2280

ccggctctgc ctcggaagag ggcaggggag aacaggtctg accaggtgac ccgaggcaca     2340

gtaacgcctc cccccaggct ggtgaaaaag aatgaggaag ctgctgatga ggtcttcaaa     2400

gacatcatgg agtccagccc gggctccagc ccgcccaacc tgactccaaa acccctccgg     2460

cggcaggtca ccgtggcccc tgcctcgggc ctcccccaca aggaagaagc tggaaagggc     2520

agtgccttag ggacccctgc tgcagctgag ccagtgaccc ccaccagcaa agcaggctca     2580

ggtgcaccag ggggcaccag caagggcccc gccgaggagt ccagagtgag gaggcacaag     2640

cactcctctg agtcgccagg gagggacaag gggaaattgt ccaggctcaa acctgccccg     2700

ccgcccccac cagcagcctc tgcagggaag gctggaggaa agccctcgca gagcccgagc     2760

caggaggcgg ccggggaggc agtcctgggc gcaaagacaa aagccacgag tctggttgat     2820

gctgtgaaca gtgacgctgc caagcccagc cagccgggag agggcctcaa aaagcccgtg     2880

ctcccggcca ctccaaagcc acagtccgcc aagccgtcgg ggacccccat cagcccagcc     2940

cccgttccct ccacgttgcc atcagcatcc tcggccctgg caggggacca gccgtcttcc     3000

accgccttca tccctctcat atcaacccga gtgtctcttc ggaaaacccg ccagcctcca     3060

gagcggatcg ccagcggcgc catcaccaag ggcgtggtcc tggacagcac cgaggcgctg     3120

tgcctcgcca tctctaggaa ctccgagcag atggccagcc acagcgcagt gctggaggcc     3180

ggcaaaaacc tctacacgtt ctgcgtgagc tatgtggatt ccatccagca aatgaggaac     3240

aagtttgcct tccgagaggc catcaacaaa ctggagaata atctccggga gcttcagatc     3300

tgcccggcga cagcaggcag tggtccagcg gccactcagg acttcagcaa gctcctcagt     3360

tcggtgaagg aaatcagtga catagtgcag aggtagcagc agtcaggggt caggtgtcag     3420

gcccgtcgga gctgcctgca gcacatgcgg gctcgcccat acccgtgaca gtggctgaca     3480

agggactagt gagtcagcac cttggcccag gagctctgcg ccaggcagag ctgagggccc     3540

tgtggagtcc agctctacta cctacgtttg caccgcctgc cctcccgcac cttcctcctc     3600

cccgctccgt ctctgtcctc gaattttatc tgtggagttc ctgctccgtg gactgcagtc     3660

ggcatgccag gacccgccag ccccgctccc acctagtgcc ccagactgag ctctccaggc     3720

caggtgggaa cggctgatgt ggactgtctt tttcattttt ttctctctgg agcccctcct     3780

cccccggctg ggcctccttc ttccacttct ccaagaatgg aagcctgaac tgaggccttg     3840

tgtgtcaggc cctctgcctg cactccctgg ccttgcccgt cgtgtgctga agacatgttt     3900

caagaaccgc atttcgggaa gggcatgcac gggcatgcac acggctggtc actctgccct     3960

ctgctgctgc ccggggtggg gtgcactcgc catttcctca cgtgcaggac agctcttgat     4020

ttgggtggaa aacagggtgc taaagccaac cagcctttgg gtcctgggca ggtgggagct     4080

gaaaaggatc gaggcatggg gcatgtcctt tccatctgtc cacatcccca gagcccagct     4140

cttgctctct tgtgacgtgc actgtgaatc ctggcaagaa agcttgagtc tcaagggtgg     4200

caggtcactg tcactgccga catccctccc ccagcagaat ggaggcaggg gacaagggag     4260

gcagtggcta gtggggtgaa cagctggtgc caaatagccc cagactgggc ccaggcaggt     4320

ctgcaagggc ccagagtgaa ccgtcctttc acacatctgg gtgccctgaa agggcccttc     4380

ccctccccca ctcctctaag acaaagtaga ttcttacaag gccctttcct ttggaacaag     4440

acagccttca cttttctgag ttcttgaagc atttcaaagc cctgcctctg tgtagccgcc     4500

ctgagagaga atagagctgc cactgggcac ctgcgcacag gtgggaggaa agggcctggc     4560

cagtcctggt cctggctgca ctcttgaact gggcgaatgt cttatttaat taccgtgagt     4620

gacatagcct catgttctgt gggggtcatc agggagggtt aggaaaacca caaacggagc     4680

ccctgaaagc ctcacgtatt tcacagagca cgcctgccat cttctccccg aggctgcccc     4740

aggccggagc ccagatacgg gggctgtgac tctgggcagg gacccggggt ctcctggacc     4800

ttgacagagc agctaactcc gagagcagtg ggcaggtggc cgcccctgag gcttcacgcc     4860

gggagaagcc accttcccac cccttcatac cgcctcgtgc cagcagcctc gcacaggccc     4920

tagctttacg ctcatcacct aaacttgtac tttatttttc tgatagaaat ggtttcctct     4980

ggatcgtttt atgcggttct tacagcacat cacctctttg cccccgacgg ctgtgacgca     5040

gccggaggga ggcactagtc accgacagcg gccttgaaga cagagcaaag cgcccaccca     5100

ggtcccccga ctgcctgtct ccatgaggta ctggtccctt ccttttgtta acgtgatgtg     5160

ccactatatt ttacacgtat ctcttggtat gcatctttta tagacgctct tttctaagtg     5220

gcgtgtgcat agcgtcctgc cctgccccct cgggggcctg tggtggctcc ccctctgctt     5280

ctcggggtcc agtgcatttt gtttctgtat atgattctct gtggtttttt ttgaatccaa     5340

atctgtcctc tgtagtattt tttaaataaa tcagtgttta catt                      5384


<210>  182
<211>  2937
<212>  DNA
<213>  Homo sapiens

<400>  182
gttagaagag acccgagaag ccttggcagg acgagcatat gcagctgaac agatggaagg       60

atttgaactg cagaccaagc agctgacccg tgaggtggag gagctgaaaa gtgaactgca      120

ggccattcga gatgagaaga atcagccaga tccccggctg caagaacttc aggaagaggc      180

tgcccgcctt aagagccatt tccaggctca gttacagcag gaaatgagaa agacagctct      240

tgcagaggat caactccgtc agcaatctca ggtagaagaa cagagggtgg cagccctgga      300

gaatcaaata tccgaggtgt ctgagctgct aggcacctac gagaaagcca agcagaagga      360

ccagctggcc attcagaagc tgaaggagcg cattctgcag ctggacctgg agaacaagac      420

actggctcta gcagcctcca gcaggtcccc tttagacagc catggagagg agtccagtct      480

ggatgtcaat gtcctgaaag ataagatgga gaagctgaag aggctgctgc aggttgcggc      540

caggaaaagc caggtgaccc tggatgtgga gaagctctgt gacctggaga taatgcccag      600

ctcggaggct gctgatgggg agaaggctac tgcactctat taccaacagg agctgaaaca      660

gctgaaggaa gagtttgaga ggtacaagat gagagcccag gttgtcctca aaagcaagaa      720

taccaaagat ggtaacctgg gaaaggagct ggaggcagcc caggaacagc ttgcagagct      780

gaaggagaag tatatttccc tgcggctctc ctgcgaggag ctggagcacc aacaccagca      840

ggaggctgat gactggaagc aggagctggc ccggctgcag cagctccacc ggcaggagct      900

ggagcggtgc cagctggact tcagggaccg cacactgaaa ctggaggagg agctgcacaa      960

gcagcgggat cgtgccctag ctgtgctcac cgagaaggac ttggaactgg agcaactgcg     1020

ttctgtggcc ttggcctctg ggctgccagg acgcagaagt cctgtgggtg gtggcggtcc     1080

tggggaccca gctgacacat catcctctga tagcctgacc caagcattac aacttgcagc     1140

ggccaatgag cccactttct ttctgtacgc tgagcaactg gcccgcaagg aggtggagat     1200

cacatcactg aggaagcaga agcacaggct ggaggtcgag gtgcatcagc tgcaggatcg     1260

gctgctggag gagggcgaac ggcatcgtga ggaggttgca gccctgcaga gccacatcga     1320

aaagaacatc agggaccaga gcagggaggg agccaatctg gagtacctca aaaacatcat     1380

ctaccgcttc ctgaccttac ctgactccct gggccgccag cagactctca cagccatact     1440

gactatcttg cacttcagtc cagaggagaa acaagtgata atgcgactcc caaccagtgc     1500

cagctggtgg ccttctggca agagatgatg ccattttcat gaattcctgg aatttctgtg     1560

cctcttttat gtgggaaagg gcaggctctg gtttctgctg cctcttctct tacattgtca     1620

tttatttctt cactgtgttg agctgggagg agtcttcaat gtgggaaggg attttctgcc     1680

aaatgccatt aatgctgctt tatccttagg ccctagagat actgaaagtc ctggggcagt     1740

atcttctgat ggtgtgcatg tgaggagaag atgaggttag gactgagaag tgcagaagtt     1800

ggaacagtgg taaggctgtt ttaaaataag atgttttgtt ttaataatat gctcctggca     1860

caaagctagg agtaaatgtg actccaaagg gagttcagtt aatctctgaa atgcacaaaa     1920

cctagctatt ttctccctct catcacagtc tgagtctggt ccattgctac cccaattctc     1980

tggggacata aaaccaggct ggaaagggac caggaagttt gaaatagtga catatcatcc     2040

actagtccca agggctaagg aatagtgagt ttattctgga aggaactggg aagcttagtc     2100

taattagtgc ctggggatga cctatgcaat cacaccgctt atgaccatcc tagagagggc     2160

cctgagcacc agcttgatct tagggatttc caaagtaacc tgctttttgc ctggataggg     2220

ttaaaataga cctttcttgc ctatccttgc cttaacctat ctgcctgagg ttggcctgag     2280

attgtgagtc aacgactttg ctatcttttc ctcagtgttg aactttcatt aagaaataaa     2340

gtcctagctt cttacagaga ggggtccaaa tggtgaatgc tcatcctgcc tggattcaag     2400

gaattagctc agagattggc ccctagcttt tctgcctttg tagggacagc aaaaggggaa     2460

aatttgctgc agaaaattcc aaaagattgc tgtagctctc acagggaagt ggtaaagatc     2520

agctaaacct gggttggggt gctttctgcc cagtgggtct tggcataagt agattaatcc     2580

tgctctttta agaaaaggca acttattcag gcagtctgga aagggggttc tcagaaaact     2640

cagtttcttt attccttctt ttctcccaac tactgttact ggttatagag gtctttggac     2700

tctaaagacc aatgtttggc cactaactgg actaatatgt atctttctgt gatttcatca     2760

tagaggtctg ttttgtgagg gtttggggtg cagaaaactt tgattaaatc ttaatgggag     2820

gctgggtgac ctggattatc tacagtgagc agacttaaat ggaacagaag tttatgtgtc     2880

caaatgatgg aatcattaaa cctgagtgac ttgaaaaaaa aaaaaaaaaa aaaaaaa        2937


<210>  183
<211>  1709
<212>  DNA
<213>  Homo sapiens

<400>  183
aagagaaaga acaagaaaaa gaaaaagaag aggaaaaaat ccccagtacc catagaaacc       60

cttaaagatg tttaaaaaga gttaacttat cagaacacag atttaagtga aattaaggaa      120

gaagagcagg taaagtctac tgacagaaag tcagcagtgg aagcccaaaa cgaggtgact      180

gaaaatccaa aacagaaaat tgcagcagaa agcagtgaaa atgttgattg tccagagaat      240

cctaaaatga agttggatgg aaaacttgac caagaaggca atgatgtaaa aacagcagct      300

gaggaggtac tagctggtag agacacatta gattttgagg atgtcacagt tcaatcatca      360

ggcccgaggg ctggtggtga agaattagat gaaggtgttg caaaagataa tgctaaaata      420

gctggtgcca cttaaagcaa tcctgaagaa ccagagagcg aagatgcaga tcactgcacc      480

gtacccaaaa atgaaagtcc ctcacaggac attagtgatg cctgtgaagc agaaagtaca      540

gagaggtgtg ggatgtcaga acatccaagt cagaccatca ggaaagcttt agacagcaat      600

agcctaaaaa accatgactt gttggcacca ggaggagagc cgggggactt caatccagaa      660

agcagagaag ataccagagg agggaacgag aagggcaaaa gcaaagaaga ccgtaccatg      720

tcctaagctg aggcaggcgg caggcgtggt gcacaggaag tctgagtgtg aggggctctt      780

ttctctccac tgccaatgac agcctttcct gcctcaggga agaagagaga gacagactac      840

agtgatggag acccactaga tgtgcacaag aggctgccat ccagtgctgg agaggaccga      900

gccgtgatgc tggggtttgc catgatgggc ttctcagtcc taatgttctt cttgctcgga      960

acaaccattc taaagccttt tatgctcagc attcagagag aagaatcgac ctgcactgcc     1020

atccacacag atatcatgga cgactggctg gactgtgcct tcacctgtgg tgtgcactgc     1080

cacggtcagg ggaagtaccc gtgtcttcag gtgtttgtga acctcagcca tccaggtcag     1140

aaagctctcc tacattataa tgaagaggct gtccagataa atcccaagtg cttttacaca     1200

cctaagtgcc accaagatag aaatgatttg ctcaacagtg ctctggacat aaaagaattc     1260

ttcgatcaca aaaatggaac ccccttttca tgcttctaca gtccagccag ccaatctgaa     1320

gatgtcattc ttataaaaaa gtatgaccaa atggctatct tccactgttt attttggcct     1380

tcactgactc tgctaggtgg tgccctgatt gttggcatgg tgagattaac acaacacctg     1440

tccttactgt gtgaaaaata tagcactgta gtcagagatg aggtaggtgg aaaagtacct     1500

tatatagaac agcatcagtt caaactgtgc attatgagga ggagcaaagg aagagcagag     1560

aaatcttaag acggtggcca aattaaagtg ctggccttca gatgtctgtg atttctgcaa     1620

ctgaggacct aattatgcct gtctgcaaac taataatgta aaaggtaata attaaagtat     1680

catattttca tgtgggaaaa aatttaaaa                                       1709


<210>  184
<211>  2592
<212>  DNA
<213>  Homo sapiens

<400>  184
ggcacgaggg ttgcctggtt gtgagagtca ggggagcagg gacaggtcca agacaaggaa       60

ggcagttggg ctgtgggaat ggggagccca gggaaggcct ccagagctgg cctggagagt      120

caccgccgag ggatgaggac gcgccagccc gggggaacgc gccagctgct ttcgcggccc      180

caagcgcgca gtgcccagca gccgcgccga gcctgacacg ctgtcctctc ccctcgcgca      240

cagggctctg cgagtgaccc ggcgggcgag ctccgtgctg catggaacgg ctgcagaagc      300

aaccacttac ctcccccggg agcgtgagcc cctcccgaga ttccagtgtg cctggctctc      360

cctccagcat cgtggccaag atggacaatc aggtgctggg ctacaaggac ctggctgcca      420

tccccaagga caaggccatc ctggacatcg agcggcccga cctcatgatc tacgagcctc      480

acttcactta ttccctcctg gaacacgtgg agctgcctcg cagccgcgag cgctcgctgt      540

cacccaaatc cacatccccc ccaccatccc cagaggtgtg ggcggacagc cggtcgcctg      600

gaatcatctc tcaggcctcg gcccccagaa ccactggaac cccccggacc agcctgcccc      660

atttccacca ccctgagacc tcccgcccag attccaacat ctacaagaag cctcccatct      720

ataagcagag agagtccgtg ggaggcagcc ctcagaccaa gcacctcatc gaggatctca      780

tcatcgagtc atccaagttt cctgcagccc agcccccaga ccccaaccag ccagccaaaa      840

tcgaaaccga ctactggcca tgccccccgt ctctggctgt tgtggagaca gaatggagga      900

agcggaaggc gtctcggagg ggagcagagg aagaggagga ggaggaagat gacgactctg      960

gagaggagat gaaggctctc agggagcgtc agagagagga actcagtaag gttacttcca     1020

acttgggaaa gatgatcttg aaagaagaga tggaaaagtc attgccgatc cgaaggaaaa     1080

cccgctctct gcctgaccgg acacccttcc atacctcctt gcaccaggga acgtctaaat     1140

cttcctctct ccccgcctat ggcaggacca ccctgagccg gctacagtcc acagagttca     1200

gcccatcagg gagtgagact ggaagcccag gcctgcagaa cggagagggc cagaggggga     1260

ggatggaccg ggggaactcc ctgccctgtg tgctggagca gaagatctat ccctatgaaa     1320

tgctagtggt gaccaacaag gggcgaacca agctgccacc gggggtggat cggatgcggc     1380

ttgagaggca tctgtctgcc gaggacttct caagggtatt tgccatgtcc cctgaagagt     1440

ttggcaagct ggctctgtgg aagcggaatg agctcaagaa gaaggcctct ctcttctgat     1500

ggcccccacc tgctccggga cggccccctt acccctgctg cttcagggtt tttccccggc     1560

gggttgggag gggcaggagg tggggtggaa atagggtggg ctcctttcct caggtagagt     1620

ggggggccaa aacctctgca gtccccggca gtgagctatg gactttcttc cccctcacaa     1680

ggctgggggc ctcctgctct cgtccctggc cctccctgca cagggcaaag ccagtctggg     1740

ctctggcaca cagagttcat gtttgcgccc tctccctgcc cctcacccca gagggtgagg     1800

aggaatgagg ggcattggtg gttaggccgg ttggctgtct tgaacagctg gagggaagat     1860

gcaggggtgg gaagcggcca ggcagaaaga gctccaggct cttgtgtcgc ccacccagcc     1920

ctcccatact cactcctgac agctttcctg cactgcagct tcctgctcct ctgactctag     1980

tgggaacagg ccccagctca gcctccggca gggaggtcac ccctccactt cagcttgccc     2040

tgacctccgc tcgcaaaccc cgagcttcca agccttttgc tccagccctg cggcttcccc     2100

agaagcctgg gcttagggtg gagatgccgc ctacacacga tcctggccct ccacctgcct     2160

ccaggccacg aaatgggaat tccagcacta agccaggcac cgggcagaag ctgggccttc     2220

cgcctccctt ggatggggtc aagaggccag gcctggcaca ttttggagtg tcctggctac     2280

cagctctcac ctacacccac gcaccccccc acacactatg ctctctcaag aatgtaattt     2340

attggggccc cccccagctg ctttcctcac ctgcccctgc cctaccttac acccccagct     2400

tgacttcttt ccagtccacg tgtgtatata atgatatcta tatttttgcc caggtctggg     2460

tattgctcct gcccagaccc tgacatccct ttccactgtg tgtgtgacca tgctggggga     2520

gggggactct gcttggaatt aaaaggttgc attgggtccc taaaaaaaaa aaaaaaaaaa     2580

aaaaaaaaaa aa                                                         2592


<210>  185
<211>  1878
<212>  DNA
<213>  Homo sapiens

<400>  185
ctgacactga acgccgcttg tcccctccgg cttgccgtcc tcgcagccat ggcggccgcc       60

gcgctcccag catggctgtc tctgcagtcg agggcaagga ctctgcgtgc attctccact      120

gccgtctact cggccactcc ggtcccgaca cctagcctgc cggaaagaac acccggaaat      180

gaaaggccac caagaagaaa ggcactacct cctaggacag agaaaatggc tgttgaccag      240

gactggccta gtgtttaccc agttgcagca ccatttaaac cctctgcagt acctcttcct      300

gttcgaatgg gttatccagt aaaaaagggc gtgcccatgg caaaggaggg aaatctagaa      360

cttttaaaga ttcccaattt tctgcatttg actcctgtag caattaaaaa gcactgtgaa      420

gcccttaaag atttttgcac tgagtggcca gccgcactgg acagtgacga gaaatgtgag      480

aagcattttc caattgaaat tgacagcact gattatgttt catcaggacc atctgttcgg      540

aaccccagag cacgagtagt agtcttaaga gtaaagcttt ccagtttgaa tttagatgat      600

cacgcaaaga agaaattaat taaacttgta ggagagcgat actgcaagac cacagatgtg      660

cttaccatca aaacagatag gtgcccttta aggaggcaga attacgatta tgcagtgtat      720

ctactaacag tgttatacca tgagtcttgg aatactgaag aatgggaaaa aagtaagact      780

gaagcagaca tggaagagta tatatgggaa aatagctcat cagaaagaaa tatcctggaa      840

acgcttctcc agatgaaagc tgctgagaaa aatatggaaa taaataaaga agagctcctt      900

ggtactaaag aaattgaaga gtacaaaaag tctgttgtta gtcttaaaaa tgaggaggaa      960

aatgaaaatt ccatttctca gtacaaagaa tccgtgaaga gactattaaa tgtgacatga     1020

attatggagt agaaaaatct gcttgattta ttaattttat gatatatgtg atcagtatct     1080

aatttgatat aaaattgaaa atgttaaaaa atcatttttt ttcctcagag ttaaaattat     1140

ttccctcata ctaatgctta atggcaatga ttactccaga gttttttaat ttttacactg     1200

gggcaataga ctaggaggtc tctgatttct tcttggtcta aagtgttttg attttatttc     1260

tacataatag ctttggtatt catgtatata catgcattta attgtgattt tatcaccttt     1320

cccatttctt tccccacaag ctggcatttc agtagttgct tttgaataat ggttttggtt     1380

acctgggaag gcaggcccag aacccatttc cttgacttgc agttccgggc tgtgttcaca     1440

tgactgctgt ctagctgatg catttttcac atttgtcaac tctggttaga aacaggtcct     1500

caggagtatt ctctaacctg atattttcta aaaagatatg ttgattcaac tttgtttagc     1560

atcctacttt ctagattgtg gggctcattt tgccagggcc aagctaccag aaaagtagaa     1620

gtggagatta cctggtatgt atctctctgg gtgccccagt tagagctgcc acagctcagg     1680

aaaaagatga ggcataacga ccttgaatgt aattggagta agtgacaaaa taagaactac     1740

cctgggaaac cctgcattca atgtagctgt caattcagta tttttaagta cacctgtcag     1800

ctgtttctta ccacttcgat ggttgtgatt aatttaaaat caaaataaag gaattactga     1860

gtttaaaaaa aaaaaaaa                                                   1878


<210>  186
<211>  2334
<212>  DNA
<213>  Homo sapiens

<400>  186
cggcgtcaag tggggcaatc gctggtggag gtggcggaga gcaaggtggc agccgggagc       60

ccatcagagg aaaagtccga ggcgctggaa ccctgcgtcc aggcgtgacg gtcatcccga      120

aaggccggcc ccagtttcat ccttttatcc tgtaatctgt caccatgacc ctgacaaaag      180

gttccttcac ctactccagt ggggaggaat atcgtggcga gtggaaggag ggccgcaggc      240

atggttttgg tcaactgatg tttgcagatg gtggcaccta cctgggtcat tttgagaatg      300

ggctctttaa tggctttggg gtattgacct tctcagatgg ttcaaggtat gagggggagt      360

ttgcccaggg caagtttaat ggcgtcggag tcttcattcg atatgacaac atgacctttg      420

agggggaatt taaaaatggc agagtagatg gttttggcct gctgactttc cctgatggtt      480

ctcatggaat cccccgcaat gaaggtctct ttgagaacaa caagctgctg cgacgtgaga      540

agtgttctgc cattgttcag cgggcccaga gcgcctccaa gtcagccaga aatctcactg      600

cctgacagcg cagtgggcac cagctgataa gtattgggta aagccagtgc ccctgttgtt      660

gattcgaggt gaacaaatga atcagagctg agatgagttg acaatgacag tggagcagag      720

gccttgtatg tgccctgtca cctgccattc cagaactgga ccacagaaaa gtgctgagga      780

tgctggccag cagaccctgc agcagtcatt ggtggttctg tctttcccta acccttatgt      840

gctggaggac agaggagcca cctcttctca ctggttgata ctctgttcct aagacctcag      900

gttacccagt gtagcctgct gtgacccttc tgcttcattt tctgccaagt gatacagaac      960

cttcgttctg ctgctttggg gacaggtgat cctagcccca gcttagggcc agtgctctgt     1020

gccactctgg agaaataggg aaaagatagg ggtggctcag tacagcagcc ctgtgaaagt     1080

caaggccaga gcttttcttt tttaattttt ttattattat tattattatt ttatttttta     1140

tttttgagat ggagttttac tctcgcccag gctagagtgc agtggcatga tctcagctca     1200

ctgcaacttc tgcctcccag gttcaagcaa ttcccctgcc tcagcttcct gagtagctgg     1260

gactacagga gcgcgccacc acacccagct aatttttgta ttttttttta gtagagacgg     1320

ggtttcacca tattggccag gctggtctca aactcctgac ctcgtgatcc acccgccttg     1380

gtctcccaaa gtgctgggat tacaggcgtg agccaccacg ctcagccttt aattttatta     1440

ttataaaaaa ttgagccagg gtcttgctat gtggctcagg ctcatctcaa aatcctgggc     1500

tcaagtgatc ctcctgcctg ggcctgccaa agtgctagga ttgcaggtgt gagccactgt     1560

gcctggctgg cagagctttt ccatatgtta ctcctcatgc tggttggaat catggctgca     1620

ggcttccact tggtctgatc agactggtat tcattcctgc ctatgtcccc gtgaaggatt     1680

cggtaagagt gctatttcct cctcccttta gaagacaggc tgtcttcttt catcaactta     1740

gagcagataa tccccatgtg tgcctctctc cttccttaga tggggaacag gatccctttt     1800

tgggacaatc aagaaaaaaa ctcatgtaaa cagtaatctt attacttgta tttgtgacta     1860

actccaggga aaagggtaga atatttaggc cacttcaggc actaccatgg agtgaactga     1920

attcatacgg atggcttggg ctgacacagt ttcttcccag tggaccaata aatcagactc     1980

acccgaaccc ctggggtttt ggtagaattg gacctactct aggactgtgg ggaactaaag     2040

gagcatttgg ctcactgtag ctcttctatc atgagccttg accgtcaggc cgcaatcaga     2100

ccttactgat gggatctctg cagtttatta cgtaggcctc ccgttaccct ggtacccaaa     2160

tacgtccccc acctctagct ccctagcctc acattgaatg tctcttcaac agcagattgt     2220

ggtggaagtt atagccgtgt gcctctattt attctctgaa ttgtactgta gaaaaaggtg     2280

tttataaaga ataaagaaat caccagaact gcctaaaaaa aaaaaaaaaa aaaa           2334


<210>  187
<211>  1548
<212>  DNA
<213>  Homo sapiens

<400>  187
tccttttctt tttaaaaaaa aaacactgca actggaacag tttctgatct caaaaggcaa       60

gcctcttccc gtgtgatctt tataatttac actcttttcc gtgagctttc ttacctccct      120

ttttttataa ctctccatat tctctattca tacatatatc cattatatta gtagtggaat      180

aatttttatt tttatttatt ttttttggct ttagtacttg caccctcaca cacactctcc      240

cgagaaccag aagtcggttg ggtgtttata taatgaagaa ttatggggct gtttgatcga      300

ggtgttcaaa tgcttttaac caccgttggt gctttcgctg ccttcagcct gatgaccata      360

gctgtgggaa ccgactattg gctctactcc agaggggttt gcaagaccaa aagtgtcagt      420

gagaatgaaa ccagcaaaaa gaacgaggaa gttatgaccc attccggatt atggagaacc      480

tgctgcctag aagggaattt caaaggtctg tgcaagcaaa ttgatcactt cccagaggat      540

gcagattacg aagctgacac agcagaatat ttcctccggg ccgtgagggc ctccagcatt      600

ttcccaatcc tgagtgtgat tctgcttttc atgggtggcc tctgcatcgc agccagcgag      660

ttctacaaaa ctcgacacaa catcatcctg agtgccggca tcttcttcgt gtctgcaggt      720

ctgagtaaca tcattggcat catagtgtac atatctgcca atgccggaga cccctccaag      780

agcgactcca aaaagaatag ttactcatac ggctggtcct tctacttcgg ggccctgtcc      840

ttcatcatcg ccgagatggt cggggtgctg gcggtgcaca tgtttatcga ccggcacaaa      900

cagctgcggg ccacggcccg cgccacggac tacctccagg cctctgccat cacccgcatc      960

cccagctacc gctaccgcta ccagcgccgc agccgctcca gctcgcgctc cacggagccc     1020

tcacactcca gggacgcctc ccccgtgggc atcaagggct tcaacaccct gccgtccacg     1080

gagatctcca tgtacacgct cagcagggac cccctgaagg ccgccaccac gcccaccgcc     1140

acctacaact ccgacaggga taacagcttc ctccaggttc acaactgtat ccagaaggag     1200

aacaaggact ctctccactc caacacagcc aaccgccgga ccacccccgt ataaagaccg     1260

cgggcctcgc cagaagaccg cgggaggagg gcgcggtccc cgggggcggg gcggggcggg     1320

gagacccaga ccctccgctg ggagaccttc caaaagcaaa aacaaaaaac aaaaaaaaca     1380

aaaaaacaaa aaacaaaaaa acacacacac acaaaaaaag agaaaaaaca taacaagtaa     1440

attttaaaaa aaagaacaaa atataagagg aacaaagaag caaaacaaca ggaaatgtgg     1500

gaaaatataa acgagggaag aaaacaaact ttaaaaaaaa gcgagagg                  1548


<210>  188
<211>  1075
<212>  DNA
<213>  Homo sapiens

<400>  188
gggggttttc ggaagttgct gggttcgttt tattcagcgg cagtggtgct ttcccgaatc       60

tcagaatgcc ttttgctccc gttgcccagg ctggagtgca atggcacgat ttccgttcac      120

tgcaacatct gcttcccgcg ttcaagcgat tctcctgcct cagccttggg agtagttggg      180

attacagtgt taaaagatca ctgaagttgg atggtctgtt agaagaaaat tcatttgatc      240

cttcaaaaat cacaaggaag aaaagtgtta taacttattc tccaacaact ggaacttgtc      300

aaatgagtct atttgcttct cccacaagtt ctgaagagca aaagcacaga aatggactat      360

caaatgaaaa gagaaaaaaa ttgaatcacc ccagtttaac tgaaagcaaa gaatctacaa      420

caaaagacaa tgatgaattc atgatgttgc tatcaaaagt tgagaaattg tcagaagaaa      480

tcatggagat aatgcaaaat ttaagtagta tacaggcttt ggagggcagt agagagcttg      540

aaaatctcat tggaatctcc tgtgcatcac atttcttaaa aagagaaatg cagaaaacca      600

aagaactaat gacaaaagtg aataaacaaa aactgtttga aaagagtaca ggacttcctc      660

acaaagcatc acgtcatctt gacagctatg aattccttaa agccatttta aactgaggca      720

ttaagaagaa atgcactcac catgagcacc aacttctgca tctgcctgat catatttaaa      780

ggaacagaga aatatttgta attaatctgc ccagtaaata ccagctcgta gcagttggca      840

ggtgcatgtc tagataaaat ttcttgcagc taatttaaac tttctacacg caccagtaga      900

taatctcaat gtaaataata catttcttct tggctcttta atgtaagcca acatggagag      960

gaagatcttg acttatattc tgtaccacat acacttctgt ggacttttag catttgtggg     1020

tagacttaat aaagcatgta taaaagtcaa aaaaaaaaaa aaaaaaaaaa aaaaa          1075


<210>  189
<211>  1788
<212>  DNA
<213>  Homo sapiens

<400>  189
tacagtaaaa agtccgagtg cagccgccgg gcgcaggatg ggatccggct cctccagcta       60

ccggcccaag gccatctacc tggacatcga tggacgcatt cagaaggtaa tcttcagcaa      120

gtactgcaac tccagcgaca tcatggacct gttctgcatc gccaccggcc tgcctcggaa      180

cacgaccatc tccctgctga ccaccgacga cgccatggtc tccatcgacc ccaccatgcc      240

cgcgaattca gaacgcactc cgtacaaagt gagacctgtg gccatcaagc aactctccga      300

gagagaagaa ttaatccaga gcgtgctggc gcaggttgca gagcagttct caagagcatt      360

caaaatcaat gaactgaaag ctgaagttgc aaatcacttg gctgtcctag agaaacgcgt      420

ggaattggaa ggactaaaag tggtggagat tgagaaatgc aagagtgaca ttaagaagat      480

gagggaggag ctggcggcca gaagcagcag gaccaactgc ccctgtaagt acagtttttt      540

ggataaccac aagaagttga ctcctcgacg cgatgttccc acttacccca agtacctgct      600

ctctccagag accatcgagg ccctgcggaa gccgaccttt gacgtctggc tttgggagcc      660

caatgagatg ctgagctgcc tggagcacat gtaccacgac ctcgggctgg tcagggactt      720

cagcatcaac cctgtcaccc tcaggaggtg gctgttctgc gtccacgaca actacagaaa      780

caaccccttc cacaacttcc ggcactgctt ctgcgtggcc cagatgatgt acagcatggt      840

ctggctctgc agtctccagg agaagttctc acaaacggat atcctgatcc taatgacagc      900

ggccatctgc cacgatctgg accatcccgg ctacaacaac acgtaccaga tcaatgcccg      960

cacagagctg gcggtccgct acaatgacat ctcaccgctg gagaaccacc actgcgccgt     1020

ggccttccag atcctcgccg agcctgagtg caacatcttc tccaacatcc cacctgatgg     1080

gttcaagcag atccgacagg gaatgatcac attaatcttg gccactgaca tggcaagaca     1140

tgcagaaatt atggattctt tcaaagagaa aatggagaat tttgactaca gcaacgagga     1200

gcacatgacc ctgctgaaga tgattttgat aaaatgctgt gatatctcta acgaggtccg     1260

tccaatggaa gtcgcagagc cttgggtgga ctgtttatta gaggaatatt ttatgcagag     1320

cgaccgtgag aagtcagaag gccttcccgt ggccccgttc atggaccgag acaaagtgac     1380

caaggccaca gcccagattg ggttcatcaa gtttgtcctg atcccaatgt ttgaaacagt     1440

gaccaagctc ttccccatgg ttgaggagat catgctgcag ccactttggg aatcccgaga     1500

tcgctacgag gagctgaagc ggatagatga cgccatgaaa gagttacaga agaagactga     1560

cagcttgacg tctggggcca ccgagaagtc cagagagaga agcagagatg tgaaaaacag     1620

tgaaggagac tgtgcctgag gaaagcgggg ggcgtggctg cagttctgga cgggctggcc     1680

gagctgcgcg ggatccttgt gcagggaaga gctgccctgg gcacctggca ccacaagacc     1740

atgttttcta agaaccattt tgttcactga tacaaaaaaa aaaaaaaa                  1788


<210>  190
<211>  2079
<212>  DNA
<213>  Homo sapiens

<400>  190
ggcacgaggg ttcgatgctg gtttagggtt tcaggcgtgg aggttccaaa atccgaggtt       60

tgatttcagc ctgcccttgc cagtgcctgg gccgctggga gccgttattg gctgccgtta      120

aggaccgtta cgtttcccgg gtccttctgg cactcctctg gtggaccgcc cccatcggcc      180

acacttgccc tgctctccag tgattctgta gctcctggct ccgtagtctc gcggacagct      240

ctctttcctg gaagatgttt ctggtgggcc tgacaggggg cattgcctca ggcaagagct      300

cagtgatcca ggtgttccag cagctgggct gtgcggtgat tgacgtggac gtgatggccc      360

ggcacgtcgt gcagccagga taccctgccc accggcgcat cgtagaggtc ttcggcactg      420

aggtcttgct ggagaatggc gacataaatc gcaaggtcct gggggacctg atctttaacc      480

agcctgaccg gcggcagctg ctcatcgcca tcacccaccc cgagattcgc aaggagatga      540

tgaaggagac gttcaagtac ttcctccggg gataccgcta cgtgattctg gatatccccc      600

tgctgtttga gaccaagaag ttgctcaagt acatgaagca caccgtggta gtatactgcg      660

accgggacac acagctggca cggctgatgc ggcggaacag cctgaaccgc aaggacgcag      720

aggcccgcat caatgcccag ctgcccctga cagacaaggc ccgcatggcc cgccatgtcc      780

tagacaactc gggcgagtgg agtgtcacca aacgccaggt catcctcttg cacactgagc      840

tggagcgctc cctggagtac ctgccgctga ggtttggggt cctcacaggg ctcgctgcca      900

ttgccagcct cctctacctg ctcacccact accttctgcc ttacgcctag tggggcactc      960

aaggcaggga gccccaggcc tccatctatc tccttggagg ctgaagccag gtaacacatc     1020

ctgtttcctc tcagccccct ccacacacac acacacacac acacacacac acacacacac     1080

acacacggac tctccgaatc agggctgggc ctctgtgcca ggccatcccg tctttggagt     1140

gtatcctatt tgaggtcaag aaatagcctg ctgtccttcc caccttccct gagcagcacc     1200

tacagaacag caaccgtgat ggtgtgtgaa agcaacagtc agagactgct atacatttct     1260

gtgggtgggg gtagggaata ctggctctgt ggccctcctc agagctggga ggccaagggt     1320

tcactgggct tgaatcctct ctaagcacct accccattat ggcctaaacc tcctcagtgg     1380

accacgggaa atcatgttgg accaagggtt tccatgttca aacagtcaac aaggccctcc     1440

cctaggttga gatatttttg atactgaagg cccaggcccc ccagtatggc ttgctgccag     1500

caagcagcaa ggattctctc gtgggtaacg ctgtagccag gcaggaccag cctcttctgg     1560

gagacccctc tccccacgta gggtttgtgt agtgctccca catcctgctt attgcctgcc     1620

acccctgctt ctcgcctgga cctcttggta ttccgtgtac accatccttg ctgtttcttg     1680

cctctgtgcc ttcaacctgc tgctcctggc ctgggatacc ttttattttc ttttatttct     1740

tcttcctttt tttttttttt tttttttttt aacctacaac tagctctcag ttcaggcact     1800

gtctaaagcc ccaggctggg ttaggtggtc taggatacca actccccctc aacattttac     1860

cttaatccaa cagtacagta attagccgaa acttgcctgg tttttcctac tagactgtaa     1920

gccctctagg gacagggaca gtgtcttatt catctctgtg ttcttagtgc agagcctggc     1980

ccgctgttgg tgtttaataa agtgtgttga tctgaaatgc cccagaccaa aaaaaaaaaa     2040

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaa                            2079


<210>  191
<211>  835
<212>  DNA
<213>  Homo sapiens

<400>  191
aggggtttgg actgctggat ctgacagact atgaggacca tggcagccgt gggctttgag       60

gagttctcag cgccgccagg ctcagagttg gcgttgcctc ccctatttgg tggccacatc      120

ctggagagcg agctggagac ggaagtggag tttgtgtcag gtggtctggg cggctcaggg      180

ctccgggagc gagatgaaga ggaagaggca gcccggggtc ggcggcggcg ccagcgggaa      240

ttaaatcgca gaaagtacca ggcactaggt cggcgctgcc gggagatcga gcaggtgaac      300

gagcgggtcc tgaacaggct ccatcaggtg cagaggataa ctcggaggct gcagcaggaa      360

cggaggttcc tcatgagagt gctggactcc tacggggatg actaccgggc cagccagttc      420

accattgtgc tggaggatga gggcagccag ggcacggatg cccccacccc aggcaatgcg      480

gagaatgagc ctccagagaa agagacactg tccccgccca gaaggactcc tgcaccccca      540

gaacccggca gcccagcccc cggtgagggg cccagtgggc ggaagaggcg gcgagtgcca      600

cgggatggac gccgagcagg aaatgcgctg actccagagc tggccccggt gcagattaag      660

gttgaggaag actttggctt tgaagcagat gaggccctgg attccagttg ggtttctcgg      720

ggtccagaca aactgctgcc ctacccgacc ctggccagcc cagcctctga ctgacgcatg      780

cccaataaac tgaccccaca ctcaaaaaaa aaaaaacaaa aaaaaaaaaa aaaaa           835


<210>  192
<211>  2824
<212>  DNA
<213>  Homo sapiens

<400>  192
ggagctgttg cggggtccgc ggggaagtct tggcggtgga gccatggtcg gccaactgag       60

cgagggggcc attgcggcca tcatgcagaa gggggataca aacataaagc ccatcctcca      120

agtcatcaac atccgtccca ttactacggg gaatagtccg ccgcgttatc gactgctcat      180

gagtgatgga ttgaacactc tatcctcttt catgttggcg acacagttga accctctcgt      240

ggaggaagaa caattgtcca gcaactgtgt atgccagatt cacagattta ttgtgaacac      300

tctgaaagac ggaaggagag tagttatctt gatggaatta gaagttttga agtcagctga      360

agcagttgga gtgaagattg gcaatccagt gccctataat gaaggactcg ggcagccgca      420

agtagctcct ccagcgccag cagccagccc agcagcaagc agcaggcccc agccgcagaa      480

tggaagctcg ggaatgggtt ctactgtttc taaggcttat ggtgcttcaa agacatttgg      540

aaaagctgca ggtcccagcc tgtcacacac ttctggggga acacagtcca aagtggtgcc      600

cattgccagc ctcactcctt accagtccaa gtggaccatt tgtgctcgtg ttaccaacaa      660

aagtcagatc cgtacctgga gcaactcccg aggggaaggg aagcttttct ccctagaact      720

ggttgacgaa agtggtgaaa tccgagctac agctttcaat gagcaagtgg acaagttctt      780

tcctcttatt gaagtgaaca aggtgtatta tttctcgaaa ggcaccctga agattgctaa      840

caagcagttc acagctgtta aaaatgacta cgagatgacc ttcaataacg agacttccgt      900

catgccctgt gaggacgacc atcatttacc tacggttcag tttgatttca cggggattga      960

tgacctcgag aacaagtcga aagactcact tgtagacatc atcgggatct gcaagagcta     1020

tgaagacgcc actaaaatca cagtgaggtc taacaacaga gaagttgcca agaggaatat     1080

ctacttgatg gacacatctg ggaaggtggt gactgctaca ctgtgggggg aagatgctga     1140

taaatttgat ggttctagac agcccgtgtt ggctatcaaa ggagcccgag tctctgattt     1200

cggtggacgg agcctctccg tgctgtcttc aagcactatc attgcgaatc ctgacatccc     1260

agaggcctat aagcttcgtg gatggtttga cgcagaagga caagccttag atggtgtttc     1320

catctctgat ctaaagagcg gcggagtcgg agggagtaac accaactgga aaaccttgta     1380

tgaggtcaaa tccgagaacc tgggccaagg cgacaagccg gactacttta gttctgtggc     1440

cacagtggtg tatcttcgca aagagaactg catgtaccaa gcctgcccga ctcaggactg     1500

caataagaaa gtgattgatc aacagaatgg attgtaccgc tgtgagaagt gcgacaccga     1560

atttcccaat ttcaagtacc gcatgatcct gtcagtaaat attgcagatt ttcaagagaa     1620

tcagtgggtg acttgtttcc aggagtctgc tgaagctatc cttggacaaa atgctgctta     1680

tcttggggaa ttaaaagaca agaatgaaca ggcatttgaa gaagttttcc agaatgccaa     1740

cttccgatct ttcatattca gagtcagggt caaagtggag acctacaacg acgagtctcg     1800

aattaaggcc actgtgatgg acgtgaagcc cgtggactac agagagtatg gccgaaggct     1860

ggtcatgagc atcaggagaa gtgcattgat gtgagaggag cagtgccaat cgggcagaag     1920

tttgcaaata ggcagaatgg aatcgatttc ctcccacctc cgtgtgacga tcccatgtta     1980

gctacacagt gcagaggctc ttgatggtgg actaagcaat ttcctccctt gtgcgcatct     2040

cagaacccat cggtaggcaa aggaaaatac gctcaggtgg ttgtggtgta gactgtgtca     2100

ggcctacgga gtcagccagt ggctagcgca agaccagtca ctccctctgc cttcaggctt     2160

ctgtcaattt cattatcatc aagcaggaat tatgtcgtaa gtcactgacc ctaactgcag     2220

accatgaagt aaattatgta actaggtttt tgcttctcca gtggtgacca cccccccccc     2280

atccccgctc acaacttggg ttcttctcag cggggcgagc tgagaagcgg tcatgagcac     2340

ctggggattt tagtaagtgt gtcttcctag aattcgaagg ctctctcttt ctagaggtgc     2400

tacatagttg gtaatgcttg gaatggcaat agggtagaat gattaatcaa aggcatatct     2460

tctatatctg aagagtatcc ttccttcagg gtttaataga ctgagtcaga tgggtctgat     2520

attaatcaaa attgtctctt ctgaggaccg ctgataagca ttgacttgct gtcccctaag     2580

gaaatccgag cggctacaaa gcgtttcttt acttttcact tcaattaatg ctgcgcttcg     2640

cttggtgagt gcgtactttt tctacctgta cacattcctg cattcatgta ttttgttttt     2700

tttgactaaa gctatgttac atggaaagga ttttgaagcc ttttgtttcc cttgctttgt     2760

tttaataaac agtatattct ttggttgtga atcctaaaaa aaaaaaaaaa aaaaaaaaaa     2820

aaaa                                                                  2824


<210>  193
<211>  938
<212>  DNA
<213>  Homo sapiens

<400>  193
caagagagag agagaggtgc aagccccaaa gcgagcgaca tgtccctttg gggagcagtc       60

cctctgcacc ccagagtgag gaggacgcag gggtcagagg tggctacagg gcaggcagag      120

gaggcacctg tagggggtgg tgggctggtg gcccaggaga agtcaggaag ggagcccagc      180

tggtgacaag agagcccaga ggtgcctggg gctgagtgtg agagcccgga agatttcagc      240

catgcctcac agctccgaca gcagtgactc cagcttcagc cgctctcctc cccctggcaa      300

acaggactca tctgatgatg tgagaagagt tcagaggagg gagaaaaatc gtattgccgc      360

ccagaagagc cgacagaggc agacacagaa ggccgacacc ctgcacctgg agagcgaaga      420

cctggagaaa cagaacgcgg ctctacgcaa ggagatcaag cagctcacag aggaactgaa      480

gtacttcacg tcggtgctga acagccacga gcccctgtgc tcggtgctgg ccgccagcac      540

gccctcgccc cccgaggtgg tgtacagcgc ccacgcattc caccaacctc atgtcagctc      600

cccgcgcttc cagccctgag cttccgatgc ggggagagca gagcctcggg aggggcacac      660

agactgtggc agagctgcgc ccatcccgca gaggcccctg tccacctgga gacccggaga      720

cagaggcctg gacaaggagt gaacacggga actgtcacga ctggaagggc gtgaggcctc      780

ccagcagtgc cgcagcgttt cgaggggcgt gtgctggacc ccaccactgt gggttgcagg      840

cccaatgcag aagagtatta agaaagatgc tcaagtccca tggcacagag caaggcgggc      900

agggaacggt tatttttcta aataaatgct ttaaaaga                              938


<210>  194
<211>  2364
<212>  DNA
<213>  Homo sapiens

<400>  194
agcggggaaa aatatggagc aggaacagga aagcatttaa tggaacaaag ttctccagga       60

tttaggcaaa ctcacctaca agatttatca gaagccactc aagatgtgaa ggaagagaat      120

cattatctta ctcctcgaag tgttctttta gagttggata atatcattgc ttccagtgat      180

tctggtgaat ccattgaaac tgatggtcca gaccaggtct ctggaagaat tgagtgtcat      240

tatgagccaa tggaatccta ttttttcaaa gagacatccc atgagtctgt ggatagcagc      300

aaagaggaac cccagaccct tccagagacc caggatgggg acctccacct gcaagaacaa      360

ggctcaggaa ttgattggtg tctttcccct gccgatgtgg aagcacagac cacaaatgac      420

caaaaggggt cggcctcact aactgttgtg caattgtcta tattaatcaa taatatcccc      480

gatgaaagcc aagtggagaa actgaacgtt ttcctttctc ctcctgatgt catcaactat      540

cttgctctca cagaagccac aggacggata tgtgtgtctc agtgggaagg cccccgacgt      600

ttgggatgca tattttgcca cggagatcat cttctggcag tgaatgacct gaaaccccag      660

agcctggagg aggtctccct gtttcttacc cggtccatcc agaaggagaa attaaagctt      720

accatcggca ggatcccaaa ttcagagaca ttccatgctg catcctgtat gtgtccctca      780

aaatgccaaa gtgctgcacc ttctcagctg gataagccta gactgaacag agctcccaag      840

aggagtccgg ccattaaaaa gagccagcag aaaggagcca gggagtaacg caccccagac      900

ccatggcagc agaaccagga tggagctggg actgtccagc tctgccccct gctgctgcca      960

tgtgatagga gacagtcggc acccccctct gaatttctgc atctgcatct taacaatggg     1020

gatgactatc ccctctctgg ttattgtatc agagatgcta agagggtcat gtggcatgat     1080

tggagaacct gggggaattg gaaggcctta ttatctcagc tattgtccca aacaccacag     1140

acacagattg ggtcagtcct tcatgtaata catgctgtgt tctgtgagga tgtggtccac     1200

acaattcctt ctttgttaag ggacatacag ttgcaaatac tcactgcaag aaggcaagat     1260

tcccaaggga gatgtgatag ctgatcaggc ttcccagaca cctccttccc aaacacctcc     1320

ttcccaacac ctccttcccc aacatccttc ccaacacctc cttcccaaca cctccttccc     1380

ccttccccaa cacctccttc cccaacacct ccttcccaac acctccttcc caaacccctc     1440

cttccccaac atccttccca acacctcctt cccaacacct ccttcccaaa cacctccttc     1500

ccaaacacct ccttcccaac acctccttcc ccaacacctc cttcccaaac acctctttcc     1560

caaacacctc cttcccagac acctccttcc caacaccgcc ttcccaacac ctccttccca     1620

aacccctctt tcccaaacac ctccttcccc aacacctcct tccccaacac ctccttccca     1680

acacctcctt cccccttccc caacaactcc ttccccaaca cctccttccc aaacatcccc     1740

ttcccaaaca cctgcctctc ttcaacccca caggccagag tgctgagaca gagtggcctt     1800

ttggattcaa taagtatctt gttctcttaa agactcagca acgattttag aagtcgcagc     1860

agttttacat cacatgcagc caagatcagc ttgctctaca agcaataaca gaactactta     1920

gcacttcaag gttgaaagtt cttcactaat ggatccattg actaattgat cctggaaggc     1980

caaaggaata aaattctttt atataaatag gaaaacaaag gcagagagct aaagcactaa     2040

tcaaatcggg gggtgttaga gcaaaaacag gcttcagaaa gagtatttta ccatgcttca     2100

catgaaaaaa atcgagcccc ggagcgatga aaggcatatt ttctttgttt ctccaagttt     2160

cataaccgtt cagttgcaga accaagaatc taaaaccagc tctgggaaac aaatgtccag     2220

atgccagcct catagttgaa cttggatttg aaaatacctt cagcacttag aagagacatt     2280

caaatacatt tcatttcctg ttacccagat tgttcggaaa gtattaaaaa tttttcattt     2340

acatgctgaa aaaaaaaaaa aaaa                                            2364


<210>  195
<211>  2734
<212>  DNA
<213>  Homo sapiens

<400>  195
cccgctcccc gcaggggtgg agcctgagcg aggagcccgc gagctctcct ctctcctctg       60

gtctccgcgg atgacgagtg gctggataac atggagtcgg gcaagatggc gcctcccaag      120

aacgctccga gagatgcctt ggtgatggca cagatcctga aggatatggg aatcacagag      180

tatgaaccaa gggttataaa tcaaatgttg gaatttgctt tccgttatgt gactacaatt      240

ctggatgatg caaaaattta ttcgagccat gctaagaaac ctaatgttga tgcagatgat      300

gtgagactgg caatccagtg tcgtgctgac caatctttta cctctcctcc cccaagagat      360

tttttactgg atatcgcaag gcagaaaaat caaacccctt tgccactgat taagccatat      420

gcaggaccta gactgccacc tgatagatac tgcttaacag ctccaaacta taggctgaag      480

tccttaatta aaaagggacc taaccaaggg agactagttc cacgattaag tgttggtgct      540

gttagtagca aacctactac tcctactata gcaaccccac aaacggtgtc tgtcccaaat      600

aaagttgcaa ctccaatgtc agtgacaagc caaagattta cggtgcagat tccaccttct      660

cagtccacac ctgtcaaacc agttcctgca acaactgcag ttcaaaatgt tctgattaat      720

ccttcaatga ttgggcccaa aaatattctt attaccacca acatggtttc gtcacagaac      780

acagccaatg aagcaaaccc actgaagaga aaacatgaag atgatgatga caatgatatt      840

atgtaaggaa tatagtctag tctagatgca tttcaaaagg aaagttggtt ttgagcccag      900

tatactgaac tagaatattc tagatcttgt tttaccttaa aagactgaaa tgtagctgca      960

gtatttttcg tcagttaaaa ctgttagatc tctttagtaa acatacaaat gtgtttttca     1020

gtaggcttca attacaaaca gttaagtact tgtttcttaa tagtttcatt aatgttgagt     1080

cctaatatgg caattctgtt tttgagacac ttttctgcct tctatcactg atagtagcat     1140

ttaagtttca gattctacag cctagtcagc agatttatct ttgacagcat aatttctgat     1200

ctacatttaa atactacttt attttataag gtaatatagt tacttactgt cactagctaa     1260

tttttttttt ttaccaaatc tctcaatata ggaaacattt tttggaaagg atggatttag     1320

aggagagatt ctaaatccat tttggatgta tttgtttctt tgacttcctt aacttccaaa     1380

ctcaactccc tttctagatc ccattcattt tctgcacctc ccccataggc ttgtttctct     1440

ccattgctat taaatgtaga aggccatacc tggaatttta aaaatattat tcctggtaat     1500

acagctcagt gtcattttcc tatttttaaa acatgctcta catgcctaat gtttcgtgat     1560

tcactttaac ctgatggttt gcatttgctg tttttcactc ttatgtcaga gcagttgggt     1620

tttacccctt agtttttatg cctgttaagc tttactgtgc ttttgacagg tagttttggg     1680

tcagttatat tcagttttag tattgtattc caagttgata actcttccat gtttcacatt     1740

tctaaattta acagagatgc tgtagcttaa aacatgtttt gataagtaat tacactggac     1800

ctaggcaaaa ccactgaaga acaagtgttc ctttttacca catacatatt atgttttgat     1860

cactgctgct tgagccccgc tattggtata attcagatca tattagcttg ttgctgagga     1920

tgtcacatat aagacaggat caaacctgaa agacactaat ggttcatcct ctataaggcc     1980

aacaaagaaa acaaattaat gtgatgtaac ttgcatttat gtgcactctg cataggtttc     2040

ccaataatac tgtaatgttg ctgaacacct ttccctgttt tccatttata cacatattaa     2100

agtcatattg ggaaagatgg caaagctttt gagaatataa acacacctgt tttgtttttc     2160

ttaagttcaa catacttttg tagaatttgt aaaataaatg ttcgtatcat aattgagaat     2220

ttatagccaa ggatcctcaa aacagaagtt tcatcttagg atagtgtttg atatatctaa     2280

gaaagtccag taacagagaa gaaatgtctc aaatgtctcg tatcagtttt agtgtttttc     2340

agtattaggg aaaggtaata taaaaacagg taaaatgtat aaaaatagac ctgatcaaca     2400

tcataggaga taaatattca ttatatagca taggatatta ttacttgaat gttctcaggg     2460

aggcagcaag tcagaaggcc taggttctag tcctagctcc atcatttacc aactgtgtga     2520

ccttacttca cctcttagcc ttgttctcct cactagcagt aggaaagtaa cacctaccct     2580

gcctacctca cagggctgtt gtgagggttc aattggtata tgtgaaaatt ctttcagaat     2640

tgtaaaatgc tatatgactg taaggaatta ttgcatttgt tccaaggtta ataaaaattt     2700

gagcttaaaa aaaaaaaaaa aaaaaaaaaa aaaa                                 2734


<210>  196
<211>  2944
<212>  DNA
<213>  Homo sapiens

<400>  196
atatgatccg ctcggcttcc tgggtctggc tgctgccgcc cgccggtgtc cgcccgtgtc       60

gcgccggggc accaaggagc cgttggaggg tccgggcgga ggcccgctcg tgtggaagtc      120

gtcgacgccg ccgctcgtcc gtcctcccgt ccgttctcgc tcccggccgc catcatgctg      180

gcgctcatct cccgcctgct ggactggttc cgttcgctct tctggaagga agagatggag      240

ctgacgctcg tggggctgca gtactcgggc aagaccacct tcgtcaatgt catcgcgtca      300

ggtcaattca gtgaagatat gatacccaca gtgggcttca acatgaggaa ggtaactaaa      360

ggtaacgtca caataaagat ctgggacata ggaggacaac cccgatttcg aagcatgtgg      420

gagcggtatt gcagaggagt caatgctatt gtttacatga tagatgctgc agatcgtgaa      480

aagatagaag cttcccgaaa tgagctacat aatcttctag ataaaccaca gttacaagga      540

attccagtgc tagtgcttgg aaacaagaga gatcttccta atgccttgga tgagaaacag      600

ctaattgaaa aaatgaatct gtctgctatt caggatagag aaatttgctg ctattcaatt      660

tcttgcaaag aaaaggataa tatagatatc acacttcagt ggcttattca gcattcaaaa      720

tctagaagaa gctgaagcat ctcttgaagt cttccagtcc ttcttggcta taatcctaga      780

attattgtcc gttcctctga agtaattccc agaatacggt ccttcctaaa ccccagaaat      840

tgcctttttc agagtctatt tctcatgtgc actgctgaag atgaatatcc ctaatccttc      900

ataaagaatc agctagagtt gtcatgataa agtcagcaca cacaaaaagg cttcttacac      960

ataccaaaaa aaatgtctta aaccatgtgt agagctttaa aaacagaaaa aaaaccccat     1020

atacttatga ccatcttaaa tcaagaaaat tgcatatttc cattctggtc tttctgggcc     1080

agatttttat attggttttc agtaaatgtc tatctataat atttcattat agagtccagt     1140

agcttaatac tgacactgac ttgatacagc acgaagtttc tagtgccaca cacagtattt     1200

agaaaacctt taggcgtgaa tgactcatgt gggatatatg taaacataat gtttatttta     1260

tctcacaaat gcatgtgaaa tgtataatta catcttagga atccaaaatg gtctgcagag     1320

agtgagcgga ggcaccagat caatgttggt tctttgcact ggtgagattc tgcctgatga     1380

atattaaaga tatcctgctt tctgagaact ctatcaccag atggcagttg ggatatggga     1440

ggaactaaag catcctgttt tgtatctgtc cagatcatta tttctgtctc ttgttttttc     1500

ttcctggttc aggatacttt tttaaggggt tgagaattga agattttcca aaagcgttca     1560

tgaatttaga gcattccacc caatataata aaacctgtta agaatgtcag tctttgttca     1620

aacatctgtt tgttctatct ccagtcatta aatcagtgct gctgcatgac actcttaact     1680

cctgactttt tatatccagt cataaagttg actttcagca caaaagatac ttataaacaa     1740

ataaaaaatt tttatttttc tctcttactg atgtaagctt tggcactctt ttgactggtg     1800

ccattagaca tcttgattat tgtgacaact ctagacctgc ctgctttatc taatgtaatc     1860

atgctcaatg tctacaggtt gtttaataat cagtcacaca gagaactgag gaactgatgc     1920

tgtttgtttg cttctatgat acagagatgt ctaaaaactt caaatggaca tgttttgtag     1980

tttagcgact tccgtataca taaagggaca tattaatact ggttcatttg taaattatta     2040

ttcatataga ccactgtagt agataaaact ctatggtaca cctgcttatg tgttgcctca     2100

cactgtgtgt gattttgttt cttttgttaa gcagcactta tgtagactgc atttccaaat     2160

gtgttgagca ctcggagtgt agtcaacagt aagttctttt aatgaatatc agttttaatt     2220

tatagactgc catggcctta aaaatattct gtacaatata ctgcactgtg ttgcacagac     2280

actacttgct tttctccatt catattttta tgagtagaat ctgggctttt aaatttctct     2340

tcttattctt tgaagcatgt tgcatactac cctggtggga tggatggttc tgtaaatgaa     2400

gggatattta aacttgctac tgttgttcaa caccattaat ggtcagtgtg aaccattaca     2460

aagaatgtgg caacttgctt gtgcctaaaa ggaggaattg gaactagaat gtgtgactct     2520

gtggggactg cataggtttg ttaattgacc tatagctaaa ccttaatgtg tttgtgtgtc     2580

tatacattgc tttccgcatt tcaagacatc cagacgctat taccaacatt ttcctgtgca     2640

ttaacctctg catgtgaaaa cttttaacag ttactgaact atgtaaatat gtgaattttt     2700

ttatttaggt ggatgcattt tttgtctgtt tactgctctt ctcagcttta ttcaataaac     2760

ttgcatttta agggttgtat tggcaatttt aacttaaaat gtgcatcatg atggaaggtg     2820

cagacttttt tggaagtttc cgagaggagg gtctatagac catttgtcag aaatcagatc     2880

agccctcaaa gaatggggtc tgtgggctag ttaaaataga aataaacttt taaaatatcc     2940

acag                                                                  2944


<210>  197
<211>  1916
<212>  DNA
<213>  Homo sapiens

<400>  197
gagtttgaaa ctgctcgcac ttggcttcaa agctggctct tggaaattga gcggagagcg       60

acgcggttgt tgtagctgcc gctgcggccg ccgcggaata ataagccggg atctaccata      120

cccattgact aactatggaa gattatacca aaatagagaa aattggagaa ggtacctatg      180

gagttgtgta taagggtaga cacaaaacta caggtcaagt ggtagccatg aaaaaaatca      240

gactagaaag tgaagaggaa ggggttccta gtactgcaat tcgggaaatt tctctattaa      300

aggaacttcg tcatccaaat atagtcagtc ttcaggatgt gcttatgcag gattccaggt      360

tatatctcat ctttgagttt ctttccatgg atctgaagaa atacttggat tctatccctc      420

ctggtcagta catggattct tcacttgtta agagttattt ataccaaatc ctacagggga      480

ttgtgttttg tcactctaga agagttcttc acagagactt aaaacctcaa aatctcttga      540

ttgatgacaa aggaacaatt aaactggctg attttggcct tgccagagct tttggaatac      600

ctatcagagt atatacacat gaggtagtaa cactctggta cagatctcca gaagtattgc      660

tggggtcagc tcgttactca actccagttg acatttggag tataggcacc atatttgctg      720

aactagcaac taagaaacca cttttccatg gggattcaga aattgatcaa ctcttcagga      780

ttttcagagc tttgggcact cccaataatg aagtgtggcc agaagtggaa tctttacagg      840

actataagaa tacatttccc aaatggaaac caggaagcct agcatcccat gtcaaaaact      900

tggatgaaaa tggcttggat ttgctctcga aaatgttaat ctatgatcca gccaaacgaa      960

tttctggcaa aatggcactg aatcatccat attttaatga tttggacaat cagattaaga     1020

agatgtagct ttctgacaaa aagtttccat atgttatatc aacagatagt tgtgttttta     1080

ttgttaactc ttgtctattt ttgtcttata tatatttctt tgttatcaaa cttcagctgt     1140

acttcgtctt ctaatttcaa aaatataact taaaaatgta aatattctat atgaatttaa     1200

atataattct gtaaatgtgt gtaggtctca ctgtaacaac tatttgttac tataataaaa     1260

ctataatatt gatgtcagga atcaggaaaa aatttgagtt ggcttaaatc atctcagtcc     1320

ttatggcagt tttattttcc tgtagttgga actactaaaa tttaggaaaa tgctaagttc     1380

aagtttcgta atgctttgaa gtatttttat gctctgaatg tttaaatgtt ctcatcagtt     1440

tcttgccatg ttgttaacta tacaacctgg ctaaagatga atatttttct actggtattt     1500

taatttttga cctaaatgtt taagcattcg gaatgagaaa actatacaga tttgagaaat     1560

gatgctaaat ttataggagt tttcagtaac ttaaaaagct aacatgagag catgccaaaa     1620

tttgctaagt cttacaaaga tcaagggctg tccgcaacag ggaagaacag ttttgaaaat     1680

ttatgaacta tcttattttt aggtaggttt tgaaagcttt ttgtctaagt gaattcttat     1740

gccttggtca gagtaataac tgaaggagtt gcttatcttg gctttcgagt ctgagtttaa     1800

aactacacat tttgacatag tgtttattag cagccatcta aaaaggctct aatgtatatt     1860

taactaaaat tactagcttt gggaattaaa ctgtttaaca aataaaaaaa aaaaaa         1916


<210>  198
<211>  4359
<212>  DNA
<213>  Homo sapiens

<400>  198
ggaggcgacg gtggagacgg ctgccctagt gggagaggcg gcggcggcgg ccgaggagga       60

ggagggggaa gcggcggcgg caaaggaaaa tgcttggaca gaagagatga gtactatttc      120

cactaaggcc tagaattgcc tactgtacaa atagtcctga tcaggcaata tacgaatggc      180

ccaaggaagc caccaaattg attttcaggt tttacatgac ctgcgacaaa aattccctga      240

agtacctgaa gttgttgtat ccaggtgcat gttacagaat aataataacc tggatgcctg      300

ctgtgctgtt ctctctcagg agagtacaag atatctttat ggtgaaggag acttgaattt      360

ttcagatgat tctggaattt ctggtctacg caatcacatg acttctctca acttggactt      420

gcaatcacag aacatttacc accatggaag agaaggaagt aggatgaatg gaagtaggac      480

tctaacgcac agcattagtg atggacaact tcaaggtggc cagtccaata gtgaactatt      540

tcagcaggag ccacagacag caccagctca agttcctcaa ggctttaatg tttttggaat      600

gtccagttcc tctggtgctt caaattcagc accacatctt ggatttcact taggcagcaa      660

aggaacatct agcctttctc aacaaactcc cagatttaat cccattatgg taactttagc      720

cccaaatatc cagactggtc gtaatactcc tacatctttg cacatacatg gtgtacctcc      780

acctgtactt aacagtccac agggaaattc tatctatatt aggccttaca ttacaactcc      840

tggtggtaca actcgacaga cacaacagca ttctggctgg gtatctcagt ttaatcccat      900

gaaccctcag caagtttatc agccttcaca gcctggtccc tggactactt gtcctgcatc      960

taatcctctg tcacatacct catctcaaca gccaaatcag caaggccacc agacctctca     1020

tgtctacatg ccaatcagtt cacctactac ttcacaacca ccaaccattc attcatctgg     1080

tagctcacag tcttctgccc atagccaata taacattcag aatatttcaa caggacctcg     1140

aaaaaaccag attgaaatca aacttgaacc cccacaaaga aataattctt caaaactgcg     1200

ttcttctgga cctcgaacct ccagcacttc ctcttcagtc aatagccaga ccttaaacag     1260

aaatcagccc actgtttaca tagctgccag ccccccaaat acggatgagc tgatgtcccg     1320

tagtcaacct aaggtctata tttcagcgaa tgctgccaca ggagatgaac aggtcatgcg     1380

gaatcagccc acactcttca tatccacaaa ctctggagca tctgctgcct ccaggaacat     1440

gtctgggcaa gtgagcatgg gtcctgcctt tattcatcac catcctccca aaagtcgagc     1500

aataggcaat aactctgcaa cctctcctcg agtggtagtc actcagccca atacgaaata     1560

cactttcaaa attacagtct ctcccaataa gccccctgca gtttcaccag gggtggtgtc     1620

ccctaccttt gaacttacaa atcttcttaa tcatcctgat cattatgtag aaaccgagaa     1680

tattcagcac ctcacggacc ctacattagc acatgtggat agaataagtg aaacacggaa     1740

actgagtatg ggatctgatg atgctgccta cacacaagat atttgaagaa taagtaattc     1800

ttggctgggc atggtggctc acgcctgtaa ttccagtgct ttgggaggcc aagatgggag     1860

gatcatttga gcccaggagt ttgagaccag ctggggcaac atatggagac tccgtctcta     1920

cagaaggttt tgaaattatg caggcatggt ggcacacacc tgtagtccca gttactcagt     1980

agactgagct cttttggtac accagaaggc cagaatggaa cgacttcaaa gagaacttga     2040

gattcaaaag aaaaagctgg ataaattaaa atctgaggtt aatgaaatgg aaaataatct     2100

aactcgaagg cgcctgaaaa gatcaaattc tatatcccag ataccttccc ttgaagaaat     2160

gcagcagctg agaagttgta atagacaact ccagattgac attgactgct taaccaaaga     2220

aattgatctt tttcaagccc gaggaccaca ttttaacccc agcgctattc ataactttta     2280

tgacaatatt ggatttgtag gtcctgtgcc accaaaaccc aaagatcaaa ggtccatcat     2340

caaaacacca aagactcaag acacagaaga tgatgaggga gctcagtgga attgtaccgc     2400

ctgtactttt ttgaaccatc cagccttaat tcgctgtgaa cagtgtgaga tgccaaggca     2460

tttctgagcc aaatggccct gtatcttctc taaaaccaca tctaaagttc aagaaactag     2520

tctgtcatcg ggaaaaagtt tcactgctac ataggatttt gtcaaattga aggtgtgaca     2580

agatggtgtt ctgctaatgt taaatgtcag cccacagagc taataatacc tcagtataat     2640

gtcatgagca gttgaaattc atcacatgaa aagtaatctg ctgaaagact tggttgccca     2700

ctgcctaact gtgtacagtg ttaccagtgt cccattatgg ataattctca atatgttaac     2760

acctaggtgt tcccaatacc tttttcccct catgtcacta ctgaattttg acaggaggaa     2820

ggaatagaat gatagcttgt tttatttgta aagctttcag tgaaacacta catacacgaa     2880

gaaaaggaac aaggtttaac tatttaagaa ccatttgctg ccgcatagtg ccattggata     2940

gggaagaact tcagaaatct gtggtactct tggccttgtc tttgtcttcc ctgaacgtgt     3000

ctccactctg tgaagccagc atctaggggc taaagatgca aaggaaagca gcatgcattg     3060

tctgtacaaa tgtgcagcga aataccccaa agcttttcct actgtacaga tctctcgagt     3120

ctgctttaag tgatttcttt tcttcttgat tattttctta tatttctata tgtatagtgt     3180

aatagccttt tgttaactaa ttttcttttt tccttttagt aattaagcac gatcatgtcc     3240

ctttttaagc cttacctgag aggaacaatg ccttaaaata aaaaagcatt aatgagatga     3300

aagtatgcac agaataactt tcctctactt attctgtact ttgccctcat gagttccaat     3360

gttgtgtgaa gacaggcaga tgctgcacag tgaattgcag atgatattac agaagtgatg     3420

tctgtaggtc acattaaata ctgacttgag cagtgggtga cacaacacag tgtttgtctt     3480

ccacagggaa gcttaaaaca aaagatattt ttaacccact gacagaacaa caaggttaag     3540

cttcatctgc ttggtgtccc acagaacttg cacaagcagt tgttattggg aaagtacagt     3600

ctcaaaacca gcaacagcag cagtacctac agcccttttt ttggagagaa gtttaaatgc     3660

tttactgttg gggcagtcca tttctaatcc tgacttggtg acagtatcat gtgtatttat     3720

aaaacaaggc tagccatatt taggacaact gaagaaaagc tggaaaaaaa aacaagcaaa     3780

cttgaacact gaagcaacct caagcatctc tttattttga tgatatattt ttgtaaggaa     3840

aatattcaga tgatcaggaa tgtatataac tgaaatcaag aaaaagaaca gtatgcattt     3900

aaaaagacag aattatgaaa ttatatgagt gcttagaatg gggctaaggg aagtgctgaa     3960

atagagcaaa ggatggaaga taatatagac taccacccac tgtaaatgtt tgcaagtggc     4020

tgtgttttaa atgggattat tacagttgat ctctatgaat gtcagagccc taactttcag     4080

gctttgcatt ttgtatatgg gaagaaatat gacaatccta ggtaattaaa ccatagaccc     4140

aaagccctta cgtttgatgc aatttatttt taaaataggc cttgtttttc agcttcatct     4200

gcagttctat gtgaagattg ataaatcagt ttttacttgt tttattaata aaacgtaatt     4260

tggatatctt gagttgatgg ttttgtgatt tagctgggta aactatcttt gtaacagata     4320

agttatttat aaaaattaaa aaacttatat tctaatgtg                            4359


<210>  199
<211>  4733
<212>  DNA
<213>  Homo sapiens

<400>  199
agtctaggcc tccgcctccg ttaccctgga gcccaggtta ccgccgctgc cacccaggag       60

ccccgatcct cgcctctgtc ccatccttgt gttcaaacct cccgcatctc ggcaacctcg      120

gcacccgccc ggcagcctcc gcaggaacca ggcacccgct ctttggcggt cagacgccga      180

ggccccagct gggagtttgg tcctaagagg gaaggcaagg aggcgggacg ccgcatcggc      240

tctgctgaag agcctgcggg ttggaggtgg gctttgaagt gggcgtggag acggcggggg      300

aggtggaggt gcgagtataa atgatcaacc agaaattatc ttcaaaggaa taaaaccaga      360

agtatgtaaa taaaaagccc aagataaaga aacagaaaag ctgacactac atgaagcaga      420

gggcaaaaaa gtttatcttc tggatgccaa tgtgaattgt ggtctacaaa tacattgtgg      480

agaaaataga ttgcacagaa atgaatatta tcaggatctg aagactgtga aaatgttttt      540

cagtattgtc gtagtctcct ctggagaaaa taatctgtga aattatgtga atagagacca      600

tttttcaaaa caatggggga aagagcagga agtccaggta ctgatcaaga aagagaggca      660

ggcaaacacc attattctta ctcatctgat tttgaaacgc cacagtcttc tggccgatca      720

tcgctggtca gttcttcacc tgcaagtgtt aggagaaaaa atcctaaaag acaaacttca      780

gatggccaag tacatcacca agcccctcgg aaaccaagcc ctaagggtct accaaacaga      840

aagggagtcc gagtgggatt tcgctcccag agcctcaata gagagccact tcggaaagat      900

actgatcttg ttacaaaacg gattctgtct gcaagactgc taaaaatcaa tgagttgcag      960

aatgaagtat ctgaactcca ggtcaagtta gctgagctgc taaaagaaaa taaatctttg     1020

aaaaggcttc agtacagaca ggagaaagcc ctgaataagt ttgaagatgc cgaaaatgaa     1080

atctcacaac ttatatttcg tcataacaat gagattacag cactcaaaga acgcttaaga     1140

aaatctcaag agaaagaacg ggcaactgag aaaagggtaa aagatacaga aagtgaacta     1200

tttaggacaa aattttcctt acagaaactg aaagagatct ctgaagctag acacctacct     1260

gaacgagatg atttggcaaa gaaactagtt tcagcagagt taaagttaga tgacaccgag     1320

agaagaatta aggagctatc gaaaaacctt gaactgagta ctaacagttt ccaacgacag     1380

ttgcttgctg aaaggaaaag ggcatatgag gctcatgatg aaaataaagt tcttcaaaag     1440

gaggtacagc gactatatca caaattaaag gaaaaggaga gagaactgga tataaaaaat     1500

atatattcta atcgtctgcc aaagtcctct ccaaataaag agaaagaact tgcattaaga     1560

aaaaatgctg catgccagag tgattttgca gacctgtgta caaaaggagt acaaaccatg     1620

gaagacttca agccagaaga atatccttta actccagaaa caattatgtg ttacgaaaac     1680

aaatgggaag aaccaggaca tcttactttg gacttgcaat ctcaaaagca agacaggcat     1740

ggagaagcag ggattctaaa cccaattatg gaaagagaag aaaaatttgt tacagatgaa     1800

gaactccatg tcgtaaaaca ggaggttgaa aagctggagg atgaatggga aagagaagaa     1860

cttgataaaa agcaaaaaga aaaggcatct ttactggaaa gagaagaaaa gccagagtgg     1920

gaaactggaa ggtaccaact aggaatgtat ccaattcaga atatggataa attgcaagga     1980

gaggaagaag aaagactgaa gagagaaatg ctacttgcta aactgaatga aattgacaga     2040

gaactccaag attctcgaaa tctaaaatac cctgttttgc cattgttacc tgattttgaa     2100

tcaaaactac actcccgaga gagaagcccc aaaacataca ggttctctga atcctcagag     2160

agattattta atgggcatca tttgcaagac atcagtttct caactccaaa aggagaaggt     2220

cagaattcag gaaatgttag aagtccagcc tcccctaatg agttcgcatt tggtagctac     2280

gtgccttcgt ttgcaaaaac atcagagagg tcaaatccat ttagtcaaaa aagtagtttt     2340

ttggatttcc aaagaaacag tatggaaaaa cttagtaaag atggtgtaga tttaattaca     2400

agaaaagaga aaaaagctaa tttgatggaa cagttatttg gtgccagtgg tagcagcacc     2460

atttcctcca aaagcagtgg cccaaattct gtggcttcca gtaaaggaga cattgaccct     2520

ctaaattttc tccctgggaa taaaggcagc agagatcaag aacatgatga agatgaaggc     2580

tttttcctca gtgaaggaag aagttttaat ccaaataggc accgattaaa acatgcagac     2640

gataaaccag cagtaaaagc agctgattct gtagaagatg aaattgaaga agtagcactg     2700

agatgactga ctagagtata cattttttct aattgtaaat attgaaatat tttaatacag     2760

tatttattat aaacatttag actttttaat gctaaaatgt ccttattaag gaatgatttt     2820

taatagctaa atacaatgca gttaaaaaga agtagatcat acatacacca catagatagt     2880

ttgccaagaa tgaaggaggc ttttttgaat gaaaccaaaa ataaaaatat gtcttgaaaa     2940

atgaaataga ttttaactct tcatccagtg ctatggcaag tttaactgca ctggaggtgg     3000

tattcctttt ctacttttat tcctatttat gtatttattt ttaatcatat tctcactgtg     3060

ctaaatacag tcttcccact aattgttgaa tgaaaattaa gggtgaaagt ctgtgttggg     3120

aagtgtagct ccggatggtg gagaaccagt gcttcttagg agcccttccc tttatggata     3180

gggccagggg tccctatctt acgtggcagt cctaagctac tcttgagtga tagcagtcac     3240

aacattggga tttcccattc ctctgaaagt acccacagct aaacactact catttcccaa     3300

tttcagtatt tactgaaatc acttacctac aattctgtta ggatattatg ttgagttcgg     3360

aagacatttc tctgtttgca aggacagtta gttgctctct gtcatagccc gcagaagctt     3420

ggctacagtg taattcctct ccttgttctc ctacactctt tgtatctcag tgactgggtg     3480

taagatttca tgccaaatgc aaggaatagt ggaaatacat accaactgca aagaatagaa     3540

aaactttatc ccaatatatt atagaaagat cttcagttca attatgtcca gagtaatata     3600

atttggcaat gttaatgctt ttaagatttg aacttgtcct caaaccaagg agacaacaat     3660

agtgtaatac tattggactt acaggattag ttttaaagca actttgaata gaagtgtttc     3720

agacatagga cttctgcctt gttgactaga gtggatagtt ttctgtttaa atgcattggt     3780

cttttggctg tttgtaattc acttcagctt atagagaagt tgatgacctt ggatcatgct     3840

gggtatgatt ggtctttaaa aagcaataat ataccaccag cccaaggaga aaacattgtt     3900

aaaatgaaga gtggtggaaa tagtgtgttg ggaagaataa aaaatttaga ttggcactta     3960

ttctaaagtg agctgttttt ttcaagaatt tactagcatt tgctcgtagt atgatttctg     4020

acgccagtca tatatactga tgaggggaag gagttactgt gttattctga gttcttataa     4080

atgcatatta ttgaatttca ttgcatgact atttgtcaag acttacctgg ttaggtctcc     4140

aattaaaaga tgtaccacct gtcatcttct aaattgtgtt cctttcattt attgggaaca     4200

gaatctctca aaagtgctaa actatattaa aaagttttct taatagattt gtatgtctga     4260

tatgtataac catttactat aatatgttgc aaatcattct aatatatgta aaacaatatt     4320

atttgtaatg cagttattgg taaaatatta tgtaatgtta attttgttcc tagctgctaa     4380

tttttctgcc aaaagtattc taattttcag gttgttttaa aggcttttaa aactttttag     4440

ttaagttttt tattcacgtc atttaaatta gttttttgct ttttttctac ctgataatct     4500

ctttaacaag atgcaacaag acagaattat taaaattaaa cctaaagtta agttacagat     4560

ttaaaggcat tatgatatta agcattaaaa ttggagatta aaatgtacaa aacagggttt     4620

tccttatgaa caaaccttac agggtaaatt gttttttttt ctaaatgtca ttaaatttat     4680

ttgtactcag aactgttact aataaaaatt aaaaatgcaa aaaaaaaaaa aaa            4733


<210>  200
<211>  1114
<212>  DNA
<213>  Homo sapiens

<400>  200
acactgcgct gcccagaggc cccgctgact cctgccagcc tccaggtccc cgtggtacca       60

aagctgaaca tggacgtgac catccagcac ccctggttca agcgcaccct ggggcccttc      120

taccccagcc ggctgttcga ccagtttttc ggcgagggcc tttttgagta tgacctgctg      180

cccttcctgt cgtccaccat cagcccctac taccgccagt ccctcttccg caccgtgctg      240

gactccggca tctctgaggt tcgatccgac cgggacaagt tcgtcatctt cctcgatgtg      300

aagcacttct ccccggagga cctcaccgtg aaggtgcagg acgactttgt ggagatccac      360

ggaaagcaca acgagcgcca ggacgaccac ggctacattt cccgtgagtt ccaccgccgc      420

taccgcctgc cgtccaacgt ggaccagtcg gccctctctt gctccctgtc tgccgatggc      480

atgctgacct tctgtggccc caagatccag actggcctgg atgccaccca cgccgagcga      540

gccatccccg tgtcgcggga ggagaagccc acctcggctc cctcgtccta agcaggcatt      600

gcctcggctg gctcccctgc agccctggcc catcatgggg ggagcaccct gagggcgggg      660

tgtctgtctt cctttgcttc ccttttttcc tttccacctt ctcacatgga atgagggttt      720

gagagagcag ccaggagagc ttagggtctc agggtgtccc agaccccgac accggccagt      780

ggcggaagtg accgcacctc acactccttt agatagcagc ctggctcccc tggggtgcag      840

gcgcctcaac tctgctgagg gtccagaagg agggggtgac ctccggccag gtgcctcctg      900

acacacctgc agcctccctc cgcggcgggc cctgcccaca cctcctgggg cgcgtgaggc      960

ccgtggggcc ggggcttctg tgcacctggg ctctcgcggc ctcttctctc agaccgtctt     1020

cctccaaccc ctctatgtag tgccgctctt ggggacatgg gtcgcccatg agagcgcagc     1080

ccgcggcaat caataaacag caggtgatac aagc                                 1114


<210>  201
<211>  921
<212>  PRT
<213>  Homo sapiens

<400>  201

Met Lys Thr Cys Trp Lys Ile Pro Val Phe Phe Phe Val Cys Ser Phe 
1               5                   10                  15      


Leu Glu Pro Trp Ala Ser Ala Ala Val Lys Arg Arg Pro Arg Phe Pro 
            20                  25                  30          


Val Asn Ser Asn Ser Asn Gly Gly Asn Glu Leu Cys Pro Lys Ile Arg 
        35                  40                  45              


Ile Gly Gln Asp Asp Leu Pro Gly Phe Asp Leu Ile Ser Gln Phe Gln 
    50                  55                  60                  


Val Asp Lys Ala Ala Ser Arg Arg Ala Ile Gln Arg Val Val Gly Ser 
65                  70                  75                  80  


Ala Thr Leu Gln Val Ala Tyr Lys Leu Gly Asn Asn Val Asp Phe Arg 
                85                  90                  95      


Ile Pro Thr Arg Asn Leu Tyr Pro Ser Gly Leu Pro Glu Glu Tyr Ser 
            100                 105                 110         


Phe Leu Thr Thr Phe Arg Met Thr Gly Ser Thr Leu Lys Lys Asn Trp 
        115                 120                 125             


Asn Ile Trp Gln Ile Gln Asp Ser Ser Gly Lys Glu Gln Val Gly Ile 
    130                 135                 140                 


Lys Ile Asn Gly Gln Thr Gln Ser Val Val Phe Ser Tyr Lys Gly Leu 
145                 150                 155                 160 


Asp Gly Ser Leu Gln Thr Ala Ala Phe Ser Asn Leu Ser Ser Leu Phe 
                165                 170                 175     


Asp Ser Gln Trp His Lys Ile Met Ile Gly Val Glu Arg Ser Ser Ala 
            180                 185                 190         


Thr Leu Phe Val Asp Cys Asn Arg Ile Glu Ser Leu Pro Ile Lys Pro 
        195                 200                 205             


Arg Gly Pro Ile Asp Ile Asp Gly Phe Ala Val Leu Gly Lys Leu Ala 
    210                 215                 220                 


Asp Asn Pro Gln Val Ser Val Pro Phe Glu Leu Gln Trp Met Leu Ile 
225                 230                 235                 240 


His Cys Asp Pro Leu Arg Pro Arg Arg Glu Thr Cys His Glu Leu Pro 
                245                 250                 255     


Ala Arg Ile Thr Pro Ser Gln Thr Thr Asp Glu Arg Gly Pro Pro Gly 
            260                 265                 270         


Glu Gln Gly Pro Pro Gly Pro Pro Gly Pro Pro Gly Val Pro Gly Ile 
        275                 280                 285             


Asp Gly Ile Asp Gly Asp Arg Gly Pro Lys Gly Pro Pro Gly Pro Pro 
    290                 295                 300                 


Gly Pro Ala Gly Glu Pro Gly Lys Pro Gly Ala Pro Gly Lys Pro Gly 
305                 310                 315                 320 


Thr Pro Gly Ala Asp Gly Leu Thr Gly Pro Asp Gly Ser Pro Gly Ser 
                325                 330                 335     


Ile Gly Ser Lys Gly Gln Lys Gly Glu Pro Gly Val Pro Gly Ser Arg 
            340                 345                 350         


Gly Phe Pro Gly Arg Gly Ile Pro Gly Pro Pro Gly Pro Pro Gly Thr 
        355                 360                 365             


Ala Gly Leu Pro Gly Glu Leu Gly Arg Val Gly Pro Val Gly Asp Pro 
    370                 375                 380                 


Gly Arg Arg Gly Pro Pro Gly Pro Pro Gly Pro Pro Gly Pro Arg Gly 
385                 390                 395                 400 


Thr Ile Gly Phe His Asp Gly Asp Pro Leu Cys Pro Asn Ala Cys Pro 
                405                 410                 415     


Pro Gly Arg Ser Gly Tyr Pro Gly Leu Pro Gly Met Arg Gly His Lys 
            420                 425                 430         


Gly Ala Lys Gly Glu Ile Gly Glu Pro Gly Arg Gln Gly His Lys Gly 
        435                 440                 445             


Glu Glu Gly Asp Gln Gly Glu Leu Gly Glu Val Gly Ala Gln Gly Pro 
    450                 455                 460                 


Pro Gly Ala Gln Gly Leu Arg Gly Ile Thr Gly Ile Val Gly Asp Lys 
465                 470                 475                 480 


Gly Glu Lys Gly Ala Arg Gly Leu Asp Gly Glu Pro Gly Pro Gln Gly 
                485                 490                 495     


Leu Pro Gly Ala Pro Gly Asp Gln Gly Gln Arg Gly Pro Pro Gly Glu 
            500                 505                 510         


Ala Gly Pro Lys Gly Asp Arg Gly Ala Glu Gly Ala Arg Gly Ile Pro 
        515                 520                 525             


Gly Leu Pro Gly Pro Lys Gly Asp Thr Gly Leu Pro Gly Val Asp Gly 
    530                 535                 540                 


Arg Asp Gly Ile Pro Gly Met Pro Gly Thr Lys Gly Glu Pro Gly Lys 
545                 550                 555                 560 


Pro Gly Pro Pro Gly Asp Ala Gly Leu Gln Gly Leu Pro Gly Val Pro 
                565                 570                 575     


Gly Ile Pro Gly Ala Lys Gly Val Ala Gly Glu Lys Gly Ser Thr Gly 
            580                 585                 590         


Ala Pro Gly Lys Pro Gly Gln Met Gly Asn Ser Gly Lys Pro Gly Gln 
        595                 600                 605             


Gln Gly Pro Pro Gly Glu Val Gly Pro Arg Gly Pro Gln Gly Leu Pro 
    610                 615                 620                 


Gly Ser Arg Gly Glu Leu Gly Pro Val Gly Ser Pro Gly Leu Pro Gly 
625                 630                 635                 640 


Lys Leu Gly Ser Leu Gly Ser Pro Gly Leu Pro Gly Leu Pro Gly Pro 
                645                 650                 655     


Pro Gly Leu Pro Gly Met Lys Gly Asp Arg Gly Val Val Gly Glu Pro 
            660                 665                 670         


Gly Pro Lys Gly Glu Gln Gly Ala Ser Gly Glu Glu Gly Glu Ala Gly 
        675                 680                 685             


Glu Arg Gly Glu Leu Gly Asp Ile Gly Leu Pro Gly Pro Lys Gly Ser 
    690                 695                 700                 


Ala Gly Asn Pro Gly Glu Pro Gly Leu Arg Gly Pro Glu Gly Ser Arg 
705                 710                 715                 720 


Gly Leu Pro Gly Val Glu Gly Pro Arg Gly Pro Pro Gly Pro Arg Gly 
                725                 730                 735     


Val Gln Gly Glu Gln Gly Ala Thr Gly Leu Pro Gly Val Gln Gly Pro 
            740                 745                 750         


Pro Gly Arg Ala Pro Thr Asp Gln His Ile Lys Gln Val Cys Met Arg 
        755                 760                 765             


Val Ile Gln Glu His Phe Ala Glu Met Ala Ala Ser Leu Lys Arg Pro 
    770                 775                 780                 


Asp Ser Gly Ala Thr Gly Leu Pro Gly Arg Pro Gly Pro Pro Gly Pro 
785                 790                 795                 800 


Pro Gly Pro Pro Gly Glu Asn Gly Phe Pro Gly Gln Met Gly Ile Arg 
                805                 810                 815     


Gly Leu Pro Gly Ile Lys Gly Pro Pro Gly Ala Leu Gly Leu Arg Gly 
            820                 825                 830         


Pro Lys Gly Asp Leu Gly Glu Lys Gly Glu Arg Gly Pro Pro Gly Arg 
        835                 840                 845             


Gly Pro Asn Gly Leu Pro Gly Ala Ile Gly Leu Pro Gly Asp Pro Gly 
    850                 855                 860                 


Pro Ala Ser Tyr Gly Lys Asn Gly Arg Asp Gly Glu Arg Gly Pro Pro 
865                 870                 875                 880 


Gly Leu Ala Gly Ile Pro Gly Val Pro Gly Pro Pro Gly Pro Pro Gly 
                885                 890                 895     


Leu Pro Gly Phe Cys Glu Pro Ala Ser Cys Thr Met Gln Ala Gly Gln 
            900                 905                 910         


Arg Ala Phe Asn Lys Gly Pro Asp Pro 
        915                 920     


<210>  202
<211>  527
<212>  PRT
<213>  Homo sapiens

<400>  202

Met Ser Leu Cys Gly Ala Arg Ala Asn Ala Lys Met Met Ala Ala Tyr 
1               5                   10                  15      


Asn Gly Gly Thr Ser Ala Ala Ala Ala Gly His His His His His His 
            20                  25                  30          


His His Leu Pro His Leu Pro Pro Pro His Leu His His His His His 
        35                  40                  45              


Pro Gln His His Leu His Pro Gly Ser Ala Ala Ala Val His Pro Val 
    50                  55                  60                  


Gln Gln His Thr Ser Ser Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala 
65                  70                  75                  80  


Ala Ala Ala Met Leu Asn Pro Gly Gln Gln Gln Pro Tyr Phe Pro Ser 
                85                  90                  95      


Pro Ala Pro Gly Gln Ala Pro Gly Pro Ala Ala Ala Ala Pro Ala Gln 
            100                 105                 110         


Val Gln Ala Ala Ala Ala Ala Thr Val Lys Ala His His His Gln His 
        115                 120                 125             


Ser His His Pro Gln Gln Gln Leu Asp Ile Glu Pro Asp Arg Pro Ile 
    130                 135                 140                 


Gly Tyr Gly Ala Phe Gly Val Val Trp Ser Val Thr Asp Pro Arg Asp 
145                 150                 155                 160 


Gly Lys Arg Val Ala Leu Lys Lys Met Pro Asn Val Phe Gln Asn Leu 
                165                 170                 175     


Val Ser Cys Lys Arg Val Phe Arg Glu Leu Lys Met Leu Cys Phe Phe 
            180                 185                 190         


Lys His Asp Asn Val Leu Ser Ala Leu Asp Ile Leu Gln Pro Pro His 
        195                 200                 205             


Ile Asp Tyr Phe Glu Glu Ile Tyr Val Val Thr Glu Leu Met Gln Ser 
    210                 215                 220                 


Asp Leu His Lys Ile Ile Val Ser Pro Gln Pro Leu Ser Ser Asp His 
225                 230                 235                 240 


Val Lys Val Phe Leu Tyr Gln Ile Leu Arg Gly Leu Lys Tyr Leu His 
                245                 250                 255     


Ser Ala Gly Ile Leu His Arg Asp Ile Lys Pro Gly Asn Leu Leu Val 
            260                 265                 270         


Asn Ser Asn Cys Val Leu Lys Ile Cys Asp Phe Gly Leu Ala Arg Val 
        275                 280                 285             


Glu Glu Leu Asp Glu Ser Arg His Met Thr Gln Glu Val Val Thr Gln 
    290                 295                 300                 


Tyr Tyr Arg Ala Pro Glu Ile Leu Met Gly Ser Arg His Tyr Ser Asn 
305                 310                 315                 320 


Ala Ile Asp Ile Trp Ser Val Gly Cys Ile Phe Ala Glu Leu Leu Gly 
                325                 330                 335     


Arg Arg Ile Leu Phe Gln Ala Gln Ser Pro Ile Gln Gln Leu Asp Leu 
            340                 345                 350         


Ile Thr Asp Leu Leu Gly Thr Pro Ser Leu Glu Ala Met Arg Thr Ala 
        355                 360                 365             


Cys Glu Gly Ala Lys Ala His Ile Leu Arg Gly Pro His Lys Gln Pro 
    370                 375                 380                 


Ser Leu Pro Val Leu Tyr Thr Leu Ser Ser Gln Ala Thr His Glu Ala 
385                 390                 395                 400 


Val His Leu Leu Cys Arg Met Leu Val Phe Asp Pro Ser Lys Arg Ile 
                405                 410                 415     


Ser Ala Lys Asp Ala Leu Ala His Pro Tyr Leu Asp Glu Gly Arg Leu 
            420                 425                 430         


Arg Tyr His Thr Cys Met Cys Lys Cys Cys Phe Ser Thr Ser Thr Gly 
        435                 440                 445             


Arg Val Tyr Thr Ser Asp Phe Glu Pro Val Thr Asn Pro Lys Phe Asp 
    450                 455                 460                 


Asp Thr Phe Glu Lys Asn Leu Ser Ser Val Arg Gln Val Lys Glu Ile 
465                 470                 475                 480 


Ile His Gln Phe Ile Leu Glu Gln Gln Lys Gly Asn Arg Val Pro Leu 
                485                 490                 495     


Cys Ile Asn Pro Gln Ser Ala Ala Phe Lys Ser Phe Ile Ser Ser Thr 
            500                 505                 510         


Val Ala Gln Pro Ser Glu Met Pro Pro Ser Pro Leu Val Trp Glu 
        515                 520                 525         


<210>  203
<211>  553
<212>  PRT
<213>  Homo sapiens

<400>  203

Met Val Asp Met Gly Ala Leu Asp Asn Leu Ile Ala Asn Thr Ala Tyr 
1               5                   10                  15      


Leu Gln Ala Arg Lys Pro Ser Asp Cys Asp Ser Lys Glu Leu Gln Arg 
            20                  25                  30          


Arg Arg Arg Ser Leu Ala Leu Pro Gly Leu Gln Gly Cys Ala Glu Leu 
        35                  40                  45              


Arg Gln Lys Leu Ser Leu Asn Phe His Ser Leu Cys Glu Gln Gln Pro 
    50                  55                  60                  


Ile Gly Arg Arg Leu Phe Arg Asp Phe Leu Ala Thr Val Pro Thr Phe 
65                  70                  75                  80  


Arg Lys Ala Ala Thr Phe Leu Glu Asp Val Gln Asn Trp Glu Leu Ala 
                85                  90                  95      


Glu Glu Gly Pro Thr Lys Asp Ser Ala Leu Gln Gly Leu Val Ala Thr 
            100                 105                 110         


Cys Ala Ser Ala Pro Ala Pro Gly Asn Pro Gln Pro Phe Leu Ser Gln 
        115                 120                 125             


Ala Val Ala Thr Lys Cys Gln Ala Ala Thr Thr Glu Glu Glu Arg Val 
    130                 135                 140                 


Ala Ala Val Thr Leu Ala Lys Ala Glu Ala Met Ala Phe Leu Gln Glu 
145                 150                 155                 160 


Gln Pro Phe Lys Asp Phe Val Thr Ser Ala Phe Tyr Asp Lys Phe Leu 
                165                 170                 175     


Gln Trp Lys Leu Phe Glu Met Gln Pro Val Ser Asp Lys Tyr Phe Thr 
            180                 185                 190         


Glu Phe Arg Val Leu Gly Lys Gly Gly Phe Gly Glu Val Cys Ala Val 
        195                 200                 205             


Gln Val Lys Asn Thr Gly Lys Met Tyr Ala Cys Lys Lys Leu Asp Lys 
    210                 215                 220                 


Lys Arg Leu Lys Lys Lys Gly Gly Glu Lys Met Ala Leu Leu Glu Lys 
225                 230                 235                 240 


Glu Ile Leu Glu Lys Val Ser Ser Pro Phe Ile Val Ser Leu Ala Tyr 
                245                 250                 255     


Ala Phe Glu Ser Lys Thr His Leu Cys Leu Val Met Ser Leu Met Asn 
            260                 265                 270         


Gly Gly Asp Leu Lys Phe His Ile Tyr Asn Val Gly Thr Arg Gly Leu 
        275                 280                 285             


Asp Met Ser Arg Val Ile Phe Tyr Ser Ala Gln Ile Ala Cys Gly Met 
    290                 295                 300                 


Leu His Leu His Glu Leu Gly Ile Val Tyr Arg Asp Met Lys Pro Glu 
305                 310                 315                 320 


Asn Val Leu Leu Asp Asp Leu Gly Asn Cys Arg Leu Ser Asp Leu Gly 
                325                 330                 335     


Leu Ala Val Glu Met Lys Gly Gly Lys Pro Ile Thr Gln Arg Ala Gly 
            340                 345                 350         


Thr Asn Gly Tyr Met Ala Pro Glu Ile Leu Met Glu Lys Val Ser Tyr 
        355                 360                 365             


Ser Tyr Pro Val Asp Trp Phe Ala Met Gly Cys Ser Ile Tyr Glu Met 
    370                 375                 380                 


Val Ala Gly Arg Thr Pro Phe Lys Asp Tyr Lys Glu Lys Val Ser Lys 
385                 390                 395                 400 


Glu Asp Leu Lys Gln Arg Thr Leu Gln Asp Glu Val Lys Phe Gln His 
                405                 410                 415     


Asp Asn Phe Thr Glu Glu Ala Lys Asp Ile Cys Arg Leu Phe Leu Ala 
            420                 425                 430         


Lys Lys Pro Glu Gln Arg Leu Gly Ser Arg Glu Lys Ser Asp Asp Pro 
        435                 440                 445             


Arg Lys His His Phe Phe Lys Thr Ile Asn Phe Pro Arg Leu Glu Ala 
    450                 455                 460                 


Gly Leu Ile Glu Pro Pro Phe Val Pro Asp Pro Ser Val Val Tyr Ala 
465                 470                 475                 480 


Lys Asp Ile Ala Glu Ile Asp Asp Phe Ser Glu Val Arg Gly Val Glu 
                485                 490                 495     


Phe Asp Asp Lys Asp Lys Gln Phe Phe Lys Asn Phe Ala Thr Gly Ala 
            500                 505                 510         


Val Pro Ile Ala Trp Gln Glu Glu Ile Ile Glu Thr Gly Leu Phe Glu 
        515                 520                 525             


Glu Leu Asn Asp Pro Asn Arg Pro Thr Gly Cys Glu Glu Gly Asn Ser 
    530                 535                 540                 


Ser Lys Ser Gly Val Cys Leu Leu Leu 
545                 550             


<210>  204
<211>  926
<212>  PRT
<213>  Homo sapiens

<400>  204

Met Val Met Ala Asp Gly Pro Arg His Leu Gln Arg Gly Pro Val Arg 
1               5                   10                  15      


Val Gly Phe Tyr Asp Ile Glu Gly Thr Leu Gly Lys Gly Asn Phe Ala 
            20                  25                  30          


Val Val Lys Leu Gly Arg His Arg Ile Thr Lys Thr Glu Val Ala Ile 
        35                  40                  45              


Lys Ile Ile Asp Lys Ser Gln Leu Asp Ala Val Asn Leu Glu Lys Ile 
    50                  55                  60                  


Tyr Arg Glu Val Gln Ile Met Lys Met Leu Asp His Pro His Ile Ile 
65                  70                  75                  80  


Lys Leu Tyr Gln Val Met Glu Thr Lys Ser Met Leu Tyr Leu Val Thr 
                85                  90                  95      


Glu Tyr Ala Lys Asn Gly Glu Ile Phe Asp Tyr Leu Ala Asn His Gly 
            100                 105                 110         


Arg Leu Asn Glu Ser Glu Ala Arg Arg Lys Phe Trp Gln Ile Leu Ser 
        115                 120                 125             


Ala Val Asp Tyr Cys His Gly Arg Lys Ile Val His Arg Asp Leu Lys 
    130                 135                 140                 


Ala Glu Asn Leu Leu Leu Asp Asn Asn Met Asn Ile Lys Ile Ala Asp 
145                 150                 155                 160 


Phe Gly Phe Gly Asn Phe Phe Lys Ser Gly Glu Leu Leu Ala Thr Trp 
                165                 170                 175     


Cys Gly Ser Pro Pro Tyr Ala Ala Pro Glu Val Phe Glu Gly Gln Gln 
            180                 185                 190         


Tyr Glu Gly Pro Gln Leu Asp Ile Trp Ser Met Gly Val Val Leu Tyr 
        195                 200                 205             


Val Leu Val Cys Gly Ala Leu Pro Phe Asp Gly Pro Thr Leu Pro Ile 
    210                 215                 220                 


Leu Arg Gln Arg Val Leu Glu Gly Arg Phe Arg Ile Pro Tyr Phe Met 
225                 230                 235                 240 


Ser Glu Asp Cys Glu His Leu Ile Arg Arg Met Leu Val Leu Asp Pro 
                245                 250                 255     


Ser Lys Arg Leu Thr Ile Ala Gln Ile Lys Glu His Lys Trp Met Leu 
            260                 265                 270         


Ile Glu Val Pro Val Gln Arg Pro Val Leu Tyr Pro Gln Glu Gln Glu 
        275                 280                 285             


Asn Glu Pro Ser Ile Gly Glu Phe Asn Glu Gln Val Leu Arg Leu Met 
    290                 295                 300                 


His Ser Leu Gly Ile Asp Gln Gln Lys Thr Ile Glu Ser Leu Gln Asn 
305                 310                 315                 320 


Lys Ser Tyr Asn His Phe Ala Ala Ile Tyr Phe Leu Leu Val Glu Arg 
                325                 330                 335     


Leu Lys Ser His Arg Ser Ser Phe Pro Val Glu Gln Arg Leu Asp Gly 
            340                 345                 350         


Arg Gln Arg Arg Pro Ser Thr Ile Ala Glu Gln Thr Val Ala Lys Ala 
        355                 360                 365             


Gln Thr Val Gly Leu Pro Val Thr Met His Ser Pro Asn Met Arg Leu 
    370                 375                 380                 


Leu Arg Ser Ala Leu Leu Pro Gln Ala Ser Asn Val Glu Ala Phe Ser 
385                 390                 395                 400 


Phe Pro Ala Ser Gly Cys Gln Ala Glu Ala Ala Phe Met Glu Glu Glu 
                405                 410                 415     


Cys Val Asp Thr Pro Lys Val Asn Gly Cys Leu Leu Asp Pro Val Pro 
            420                 425                 430         


Pro Val Leu Val Arg Lys Gly Cys Gln Ser Leu Pro Ser Asn Met Met 
        435                 440                 445             


Glu Thr Ser Ile Asp Glu Gly Leu Glu Thr Glu Gly Glu Ala Glu Glu 
    450                 455                 460                 


Asp Pro Ala His Ala Phe Glu Ala Phe Gln Ser Thr Arg Ser Gly Gln 
465                 470                 475                 480 


Arg Arg His Thr Leu Ser Glu Val Thr Asn Gln Leu Val Val Met Pro 
                485                 490                 495     


Gly Ala Gly Lys Ile Phe Ser Met Asn Asp Ser Pro Ser Leu Asp Ser 
            500                 505                 510         


Val Asp Ser Glu Tyr Asp Met Gly Ser Val Gln Arg Asp Leu Asn Phe 
        515                 520                 525             


Leu Glu Asp Asn Pro Ser Leu Lys Asp Ile Met Leu Ala Asn Gln Pro 
    530                 535                 540                 


Ser Pro Arg Met Thr Ser Pro Phe Ile Ser Leu Arg Pro Thr Asn Pro 
545                 550                 555                 560 


Ala Met Gln Ala Leu Ser Ser Gln Lys Arg Glu Val His Asn Arg Ser 
                565                 570                 575     


Pro Val Ser Phe Arg Glu Gly Arg Arg Ala Ser Asp Thr Ser Leu Thr 
            580                 585                 590         


Gln Gly Ile Val Ala Phe Arg Gln His Leu Gln Asn Leu Ala Arg Thr 
        595                 600                 605             


Lys Gly Ile Leu Glu Leu Asn Lys Val Gln Leu Leu Tyr Glu Gln Ile 
    610                 615                 620                 


Gly Pro Glu Ala Asp Pro Asn Leu Ala Pro Ala Ala Pro Gln Leu Gln 
625                 630                 635                 640 


Asp Leu Ala Ser Ser Cys Pro Gln Glu Glu Val Ser Gln Gln Gln Glu 
                645                 650                 655     


Ser Val Ser Thr Leu Pro Ala Ser Val His Pro Gln Leu Ser Pro Arg 
            660                 665                 670         


Gln Ser Leu Glu Thr Gln Tyr Leu Gln His Arg Leu Gln Lys Pro Ser 
        675                 680                 685             


Leu Leu Ser Lys Ala Gln Asn Thr Cys Gln Leu Tyr Cys Lys Glu Pro 
    690                 695                 700                 


Pro Arg Ser Leu Glu Gln Gln Leu Gln Glu His Arg Leu Gln Gln Lys 
705                 710                 715                 720 


Arg Leu Phe Leu Gln Lys Gln Ser Gln Leu Gln Ala Tyr Phe Asn Gln 
                725                 730                 735     


Met Gln Ile Ala Glu Ser Ser Tyr Pro Gln Pro Ser Gln Gln Leu Pro 
            740                 745                 750         


Leu Pro Arg Gln Glu Thr Pro Pro Pro Ser Gln Gln Ala Pro Pro Phe 
        755                 760                 765             


Ser Leu Thr Gln Pro Leu Ser Pro Val Leu Glu Pro Ser Ser Glu Gln 
    770                 775                 780                 


Met Gln Tyr Ser Pro Phe Leu Ser Gln Tyr Gln Glu Met Gln Leu Gln 
785                 790                 795                 800 


Pro Leu Pro Ser Thr Ser Gly Pro Arg Ala Ala Pro Pro Leu Pro Thr 
                805                 810                 815     


Gln Leu Gln Gln Gln Gln Pro Pro Pro Pro Pro Pro Pro Pro Pro Pro 
            820                 825                 830         


Arg Gln Pro Gly Ala Ala Pro Ala Pro Leu Gln Phe Ser Tyr Gln Thr 
        835                 840                 845             


Cys Glu Leu Pro Ser Ala Ala Ser Pro Ala Pro Asp Tyr Pro Thr Pro 
    850                 855                 860                 


Cys Gln Tyr Pro Val Asp Gly Ala Gln Gln Ser Asp Leu Thr Gly Pro 
865                 870                 875                 880 


Asp Cys Pro Arg Ser Pro Gly Leu Gln Glu Ala Pro Ser Ser Tyr Asp 
                885                 890                 895     


Pro Leu Ala Leu Ser Glu Leu Pro Gly Leu Phe Asp Cys Glu Met Leu 
            900                 905                 910         


Asp Ala Val Asp Pro Gln His Asn Gly Tyr Val Leu Val Asn 
        915                 920                 925     


<210>  205
<211>  677
<212>  PRT
<213>  Homo sapiens

<400>  205

Met Gln Pro Thr Leu Leu Leu Ser Leu Leu Gly Ala Val Gly Leu Ala 
1               5                   10                  15      


Ala Val Asn Ser Met Pro Val Asp Asn Arg Asn His Asn Glu Gly Met 
            20                  25                  30          


Val Thr Arg Cys Ile Ile Glu Val Leu Ser Asn Ala Leu Ser Lys Ser 
        35                  40                  45              


Ser Ala Pro Pro Ile Thr Pro Glu Cys Arg Gln Val Leu Lys Thr Ser 
    50                  55                  60                  


Arg Lys Asp Val Lys Asp Lys Glu Thr Thr Glu Asn Glu Asn Thr Lys 
65                  70                  75                  80  


Phe Glu Val Arg Leu Leu Arg Asp Pro Ala Asp Ala Ser Glu Ala His 
                85                  90                  95      


Glu Ser Ser Ser Arg Gly Glu Ala Gly Ala Pro Gly Glu Glu Asp Ile 
            100                 105                 110         


Gln Gly Pro Thr Lys Ala Asp Thr Glu Lys Trp Ala Glu Gly Gly Gly 
        115                 120                 125             


His Ser Arg Glu Arg Ala Asp Glu Pro Gln Trp Ser Leu Tyr Pro Ser 
    130                 135                 140                 


Asp Ser Gln Val Ser Glu Glu Val Lys Thr Arg His Ser Glu Lys Ser 
145                 150                 155                 160 


Gln Arg Glu Asp Glu Glu Glu Glu Glu Gly Glu Asn Tyr Gln Lys Gly 
                165                 170                 175     


Glu Arg Gly Glu Asp Ser Ser Glu Glu Lys His Leu Glu Glu Pro Gly 
            180                 185                 190         


Glu Thr Gln Asn Ala Phe Leu Asn Glu Arg Lys Gln Ala Ser Ala Ile 
        195                 200                 205             


Lys Lys Glu Glu Leu Val Ala Arg Ser Glu Thr His Ala Ala Gly His 
    210                 215                 220                 


Ser Gln Glu Lys Thr His Ser Arg Glu Lys Ser Ser Gln Glu Ser Gly 
225                 230                 235                 240 


Glu Glu Ala Gly Ser Gln Glu Asn His Pro Gln Glu Ser Lys Gly Gln 
                245                 250                 255     


Pro Arg Ser Gln Glu Glu Ser Glu Glu Gly Glu Glu Asp Ala Thr Ser 
            260                 265                 270         


Glu Val Asp Lys Arg Arg Thr Arg Pro Arg His His His Gly Arg Ser 
        275                 280                 285             


Arg Pro Asp Arg Ser Ser Gln Gly Gly Ser Leu Pro Ser Glu Glu Lys 
    290                 295                 300                 


Gly His Pro Gln Glu Glu Ser Glu Glu Ser Asn Val Ser Met Ala Ser 
305                 310                 315                 320 


Leu Gly Glu Lys Arg Asp His His Ser Thr His Tyr Arg Ala Ser Glu 
                325                 330                 335     


Glu Glu Pro Glu Tyr Gly Glu Glu Ile Lys Gly Tyr Pro Gly Val Gln 
            340                 345                 350         


Ala Pro Glu Asp Leu Glu Trp Glu Arg Tyr Arg Gly Arg Gly Ser Glu 
        355                 360                 365             


Glu Tyr Arg Ala Pro Arg Pro Gln Ser Glu Glu Ser Trp Asp Glu Glu 
    370                 375                 380                 


Asp Lys Arg Asn Tyr Pro Ser Leu Glu Leu Asp Lys Met Ala His Gly 
385                 390                 395                 400 


Tyr Gly Glu Glu Ser Glu Glu Glu Arg Gly Leu Glu Pro Gly Lys Gly 
                405                 410                 415     


Arg His His Arg Gly Arg Gly Gly Glu Pro Arg Ala Tyr Phe Met Ser 
            420                 425                 430         


Asp Thr Arg Glu Glu Lys Arg Phe Leu Gly Glu Gly His His Arg Val 
        435                 440                 445             


Gln Glu Asn Gln Met Asp Lys Ala Arg Arg His Pro Gln Gly Ala Trp 
    450                 455                 460                 


Lys Glu Leu Asp Arg Asn Tyr Leu Asn Tyr Gly Glu Glu Gly Ala Pro 
465                 470                 475                 480 


Gly Lys Trp Gln Gln Gln Gly Asp Leu Gln Asp Thr Lys Glu Asn Arg 
                485                 490                 495     


Glu Glu Ala Arg Phe Gln Asp Lys Gln Tyr Ser Ser His His Thr Ala 
            500                 505                 510         


Glu Lys Arg Lys Arg Leu Gly Glu Leu Phe Asn Pro Tyr Tyr Asp Pro 
        515                 520                 525             


Leu Gln Trp Lys Ser Ser His Phe Glu Arg Arg Asp Asn Met Asn Asp 
    530                 535                 540                 


Asn Phe Leu Glu Gly Glu Glu Glu Asn Glu Leu Thr Leu Asn Glu Lys 
545                 550                 555                 560 


Asn Phe Phe Pro Glu Tyr Asn Tyr Asp Trp Trp Glu Lys Lys Pro Phe 
                565                 570                 575     


Ser Glu Asp Val Asn Trp Gly Tyr Glu Lys Arg Asn Leu Ala Arg Val 
            580                 585                 590         


Pro Lys Leu Asp Leu Lys Arg Gln Tyr Asp Arg Val Ala Gln Leu Asp 
        595                 600                 605             


Gln Leu Leu His Tyr Arg Lys Lys Ser Ala Glu Phe Pro Asp Phe Tyr 
    610                 615                 620                 


Asp Ser Glu Glu Pro Val Ser Thr His Gln Glu Ala Glu Asn Glu Lys 
625                 630                 635                 640 


Asp Arg Ala Asp Gln Thr Val Leu Thr Glu Asp Glu Lys Lys Glu Leu 
                645                 650                 655     


Glu Asn Leu Ala Ala Met Asp Leu Glu Leu Gln Lys Ile Ala Glu Lys 
            660                 665                 670         


Phe Ser Gln Arg Gly 
        675         


<210>  206
<211>  463
<212>  PRT
<213>  Homo sapiens

<400>  206

Met Arg Ala Gly Pro Glu Pro Gln Ala Leu Ala Gly Gln Lys Arg Gly 
1               5                   10                  15      


Ala Leu Arg Leu Leu Val Pro Arg Leu Val Leu Thr Val Ser Ala Pro 
            20                  25                  30          


Ala Glu Val Arg Arg Arg Val Leu Arg Pro Val Leu Ser Trp Met Asp 
        35                  40                  45              


Arg Glu Thr Arg Ala Leu Ala Asp Ser His Phe Arg Gly Leu Gly Val 
    50                  55                  60                  


Asp Val Pro Gly Val Gly Gln Ala Pro Gly Arg Val Ala Phe Val Ser 
65                  70                  75                  80  


Glu Pro Gly Ala Phe Ser Tyr Ala Asp Phe Val Arg Gly Phe Leu Leu 
                85                  90                  95      


Pro Asn Leu Pro Cys Val Phe Ser Ser Ala Phe Thr Gln Gly Trp Gly 
            100                 105                 110         


Ser Arg Arg Arg Trp Val Thr Pro Ala Gly Arg Pro Asp Phe Asp His 
        115                 120                 125             


Leu Leu Arg Thr Tyr Gly Asp Val Val Val Pro Val Ala Asn Cys Gly 
    130                 135                 140                 


Val Gln Glu Tyr Asn Ser Asn Pro Lys Glu His Met Thr Leu Arg Asp 
145                 150                 155                 160 


Tyr Ile Thr Tyr Trp Lys Glu Tyr Ile Gln Ala Gly Tyr Ser Ser Pro 
                165                 170                 175     


Arg Gly Cys Leu Tyr Leu Lys Asp Trp His Leu Cys Arg Asp Phe Pro 
            180                 185                 190         


Val Glu Asp Val Phe Thr Leu Pro Val Tyr Phe Ser Ser Asp Trp Leu 
        195                 200                 205             


Asn Glu Phe Trp Asp Ala Leu Asp Val Asp Asp Tyr Arg Phe Val Tyr 
    210                 215                 220                 


Ala Gly Pro Ala Gly Ser Trp Ser Pro Phe His Ala Asp Ile Phe Arg 
225                 230                 235                 240 


Ser Phe Ser Trp Ser Val Asn Val Cys Gly Arg Lys Lys Trp Leu Leu 
                245                 250                 255     


Phe Pro Pro Gly Gln Glu Glu Ala Leu Arg Asp Arg His Gly Asn Leu 
            260                 265                 270         


Pro Tyr Asp Val Thr Ser Pro Ala Leu Cys Asp Thr His Leu His Pro 
        275                 280                 285             


Arg Asn Gln Leu Ala Gly Pro Pro Leu Glu Ile Thr Gln Glu Ala Gly 
    290                 295                 300                 


Glu Met Val Phe Val Pro Ser Gly Trp His His Gln Val His Asn Leu 
305                 310                 315                 320 


Asp Asp Thr Ile Ser Ile Asn His Asn Trp Val Asn Gly Phe Asn Leu 
                325                 330                 335     


Ala Asn Met Trp Arg Phe Leu Gln Gln Glu Leu Cys Ala Val Gln Glu 
            340                 345                 350         


Glu Val Ser Glu Trp Arg Asp Ser Met Pro Asp Trp His His His Cys 
        355                 360                 365             


Gln Val Ile Met Arg Ser Cys Ser Gly Ile Asn Phe Glu Glu Phe Tyr 
    370                 375                 380                 


His Phe Leu Lys Val Ile Ala Glu Lys Arg Leu Leu Val Leu Arg Glu 
385                 390                 395                 400 


Ala Ala Ala Glu Asp Gly Ala Gly Leu Gly Phe Glu Gln Ala Ala Phe 
                405                 410                 415     


Asp Val Gly Arg Ile Thr Glu Val Leu Ala Ser Leu Val Ala His Pro 
            420                 425                 430         


Asp Phe Gln Arg Val Asp Thr Ser Ala Phe Ser Pro Gln Pro Lys Glu 
        435                 440                 445             


Leu Leu Gln Gln Leu Arg Glu Ala Val Asp Ala Ala Ala Ala Pro 
    450                 455                 460             


<210>  207
<211>  1914
<212>  PRT
<213>  Homo sapiens

<400>  207

Met Gly Asp Val Lys Leu Val Ala Ser Ser His Ile Ser Lys Thr Ser 
1               5                   10                  15      


Leu Ser Val Asp Pro Ser Arg Val Asp Ser Met Pro Leu Thr Glu Ala 
            20                  25                  30          


Pro Ala Phe Ile Leu Pro Pro Arg Asn Leu Cys Ile Lys Glu Gly Ala 
        35                  40                  45              


Thr Ala Lys Phe Glu Gly Arg Val Arg Gly Tyr Pro Glu Pro Gln Val 
    50                  55                  60                  


Thr Trp His Arg Asn Gly Gln Pro Ile Thr Ser Gly Gly Arg Phe Leu 
65                  70                  75                  80  


Leu Asp Cys Gly Ile Arg Gly Thr Phe Ser Leu Val Ile His Ala Val 
                85                  90                  95      


His Glu Glu Asp Arg Gly Lys Tyr Thr Cys Glu Ala Thr Asn Gly Ser 
            100                 105                 110         


Gly Ala Arg Gln Val Thr Val Glu Leu Thr Val Glu Gly Ser Phe Ala 
        115                 120                 125             


Lys Gln Leu Gly Gln Pro Val Val Ser Lys Thr Leu Gly Asp Arg Phe 
    130                 135                 140                 


Ser Ala Ser Ala Val Glu Thr Arg Pro Ser Ile Trp Gly Glu Cys Pro 
145                 150                 155                 160 


Pro Lys Phe Ala Thr Lys Leu Gly Arg Val Val Val Lys Glu Gly Gln 
                165                 170                 175     


Met Gly Arg Phe Ser Cys Lys Ile Thr Gly Arg Pro Gln Pro Gln Val 
            180                 185                 190         


Thr Trp Leu Lys Gly Asn Val Pro Leu Gln Pro Ser Ala Arg Val Ser 
        195                 200                 205             


Val Ser Glu Lys Asn Gly Met Gln Val Leu Glu Ile His Gly Val Asn 
    210                 215                 220                 


Gln Asp Asp Val Gly Val Tyr Thr Cys Leu Val Val Asn Gly Ser Gly 
225                 230                 235                 240 


Lys Ala Ser Met Ser Ala Glu Leu Ser Ile Gln Gly Leu Asp Ser Ala 
                245                 250                 255     


Asn Arg Ser Phe Val Arg Glu Thr Lys Ala Thr Asn Ser Asp Val Arg 
            260                 265                 270         


Lys Glu Val Thr Asn Val Ile Ser Lys Glu Ser Lys Leu Asp Ser Leu 
        275                 280                 285             


Glu Ala Ala Ala Lys Ser Lys Asn Cys Ser Ser Pro Gln Arg Gly Gly 
    290                 295                 300                 


Ser Pro Pro Trp Ala Ala Asn Ser Gln Pro Gln Pro Pro Arg Glu Ser 
305                 310                 315                 320 


Lys Leu Glu Ser Cys Lys Asp Ser Pro Arg Thr Ala Pro Gln Thr Pro 
                325                 330                 335     


Val Leu Gln Lys Thr Ser Ser Ser Ile Thr Leu Gln Ala Ala Arg Val 
            340                 345                 350         


Gln Pro Glu Pro Arg Ala Pro Gly Leu Gly Val Leu Ser Pro Ser Gly 
        355                 360                 365             


Glu Glu Arg Lys Arg Pro Ala Pro Pro Arg Pro Ala Thr Phe Pro Thr 
    370                 375                 380                 


Arg Gln Pro Gly Leu Gly Ser Gln Asp Val Val Ser Lys Ala Ala Asn 
385                 390                 395                 400 


Arg Arg Ile Pro Met Glu Gly Gln Arg Asp Ser Ala Phe Pro Lys Phe 
                405                 410                 415     


Glu Ser Lys Pro Gln Ser Gln Glu Val Lys Glu Asn Gln Thr Val Lys 
            420                 425                 430         


Phe Arg Cys Glu Val Ser Gly Ile Pro Lys Pro Glu Val Ala Trp Phe 
        435                 440                 445             


Leu Glu Gly Thr Pro Val Arg Arg Gln Glu Gly Ser Ile Glu Val Tyr 
    450                 455                 460                 


Glu Asp Ala Gly Ser His Tyr Leu Cys Leu Leu Lys Ala Arg Thr Arg 
465                 470                 475                 480 


Asp Ser Gly Thr Tyr Ser Cys Thr Ala Ser Asn Ala Gln Gly Gln Val 
                485                 490                 495     


Ser Cys Ser Trp Thr Leu Gln Val Glu Arg Leu Ala Val Met Glu Val 
            500                 505                 510         


Ala Pro Ser Phe Ser Ser Val Leu Lys Asp Cys Ala Val Ile Glu Gly 
        515                 520                 525             


Gln Asp Phe Val Leu Gln Cys Ser Val Arg Gly Thr Pro Val Pro Arg 
    530                 535                 540                 


Ile Thr Trp Leu Leu Asn Gly Gln Pro Ile Gln Tyr Ala Arg Ser Thr 
545                 550                 555                 560 


Cys Glu Ala Gly Val Ala Glu Leu His Ile Gln Asp Ala Leu Pro Glu 
                565                 570                 575     


Asp His Gly Thr Tyr Thr Cys Leu Ala Glu Asn Ala Leu Gly Gln Val 
            580                 585                 590         


Ser Cys Ser Ala Trp Val Thr Val His Glu Lys Lys Ser Ser Arg Lys 
        595                 600                 605             


Ser Glu Tyr Leu Leu Pro Val Ala Pro Ser Lys Pro Thr Ala Pro Ile 
    610                 615                 620                 


Phe Leu Gln Gly Leu Ser Asp Leu Lys Val Met Asp Gly Ser Gln Val 
625                 630                 635                 640 


Thr Met Thr Val Gln Val Ser Gly Asn Pro Pro Pro Glu Val Ile Trp 
                645                 650                 655     


Leu His Asn Gly Asn Glu Ile Gln Glu Ser Glu Asp Phe His Phe Glu 
            660                 665                 670         


Gln Arg Gly Thr Gln His Ser Leu Trp Ile Gln Glu Val Phe Pro Glu 
        675                 680                 685             


Asp Thr Gly Thr Tyr Thr Cys Glu Ala Trp Asn Ser Ala Gly Glu Val 
    690                 695                 700                 


Arg Thr Gln Ala Val Leu Thr Val Gln Glu Pro His Asp Gly Thr Gln 
705                 710                 715                 720 


Pro Trp Phe Ile Ser Lys Pro Arg Ser Val Thr Ala Ser Leu Gly Gln 
                725                 730                 735     


Ser Val Leu Ile Ser Cys Ala Ile Ala Gly Asp Pro Phe Pro Thr Val 
            740                 745                 750         


His Trp Leu Arg Asp Gly Lys Ala Leu Cys Lys Asp Thr Gly His Phe 
        755                 760                 765             


Glu Val Leu Gln Asn Glu Asp Val Phe Thr Leu Val Leu Lys Lys Val 
    770                 775                 780                 


Gln Pro Trp His Ala Gly Gln Tyr Glu Ile Leu Leu Lys Asn Arg Val 
785                 790                 795                 800 


Gly Glu Cys Ser Cys Gln Val Ser Leu Met Leu Gln Asn Ser Ser Ala 
                805                 810                 815     


Arg Ala Leu Pro Arg Gly Arg Glu Pro Ala Ser Cys Glu Asp Leu Cys 
            820                 825                 830         


Gly Gly Gly Val Gly Ala Asp Gly Gly Gly Ser Asp Arg Tyr Gly Ser 
        835                 840                 845             


Leu Arg Pro Gly Trp Pro Ala Arg Gly Gln Gly Trp Leu Glu Glu Glu 
    850                 855                 860                 


Asp Gly Glu Asp Val Arg Gly Val Leu Lys Arg Arg Val Glu Thr Arg 
865                 870                 875                 880 


Gln His Thr Glu Glu Ala Ile Arg Gln Gln Glu Val Glu Gln Leu Asp 
                885                 890                 895     


Phe Arg Asp Leu Leu Gly Lys Lys Val Ser Thr Lys Thr Leu Ser Glu 
            900                 905                 910         


Asp Asp Leu Lys Glu Ile Pro Ala Glu Gln Met Asp Phe Arg Ala Asn 
        915                 920                 925             


Leu Gln Arg Gln Val Lys Pro Lys Thr Val Ser Glu Glu Glu Arg Lys 
    930                 935                 940                 


Val His Ser Pro Gln Gln Val Asp Phe Arg Ser Val Leu Ala Lys Lys 
945                 950                 955                 960 


Gly Thr Ser Lys Thr Pro Val Pro Glu Lys Val Pro Pro Pro Lys Pro 
                965                 970                 975     


Ala Thr Pro Asp Phe Arg Ser Val Leu Gly Gly Lys Lys Lys Leu Pro 
            980                 985                 990         


Ala Glu Asn Gly Ser Ser Ser Ala  Glu Thr Leu Asn Ala  Lys Ala Val 
        995                 1000                 1005             


Glu Ser  Ser Lys Pro Leu Ser  Asn Ala Gln Pro Ser  Gly Pro Leu 
    1010                 1015                 1020             


Lys Pro  Val Gly Asn Ala Lys  Pro Ala Glu Thr Leu  Lys Pro Met 
    1025                 1030                 1035             


Gly Asn  Ala Lys Pro Ala Glu  Thr Leu Lys Pro Met  Gly Asn Ala 
    1040                 1045                 1050             


Lys Pro  Asp Glu Asn Leu Lys  Ser Ala Ser Lys Glu  Glu Leu Lys 
    1055                 1060                 1065             


Lys Asp  Val Lys Asn Asp Val  Asn Cys Lys Arg Gly  His Ala Gly 
    1070                 1075                 1080             


Thr Thr  Asp Asn Glu Lys Arg  Ser Glu Ser Gln Gly  Thr Ala Pro 
    1085                 1090                 1095             


Ala Phe  Lys Gln Lys Leu Gln  Asp Val His Val Ala  Glu Gly Lys 
    1100                 1105                 1110             


Lys Leu  Leu Leu Gln Cys Gln  Val Ser Ser Asp Pro  Pro Ala Thr 
    1115                 1120                 1125             


Ile Ile  Trp Thr Leu Asn Gly  Lys Thr Leu Lys Thr  Thr Lys Phe 
    1130                 1135                 1140             


Ile Ile  Leu Ser Gln Glu Gly  Ser Leu Cys Ser Val  Ser Ile Glu 
    1145                 1150                 1155             


Lys Ala  Leu Pro Glu Asp Arg  Gly Leu Tyr Lys Cys  Val Ala Lys 
    1160                 1165                 1170             


Asn Asp  Ala Gly Gln Ala Glu  Cys Ser Cys Gln Val  Thr Val Asp 
    1175                 1180                 1185             


Asp Ala  Pro Ala Ser Glu Asn  Thr Lys Ala Pro Glu  Met Lys Ser 
    1190                 1195                 1200             


Arg Arg  Pro Lys Ser Ser Leu  Pro Pro Val Leu Gly  Thr Glu Ser 
    1205                 1210                 1215             


Asp Ala  Thr Val Lys Lys Lys  Pro Ala Pro Lys Thr  Pro Pro Lys 
    1220                 1225                 1230             


Ala Ala  Met Pro Pro Gln Ile  Ile Gln Phe Pro Glu  Asp Gln Lys 
    1235                 1240                 1245             


Val Arg  Ala Gly Glu Ser Val  Glu Leu Phe Gly Lys  Val Thr Gly 
    1250                 1255                 1260             


Thr Gln  Pro Ile Thr Cys Thr  Trp Met Lys Phe Arg  Lys Gln Ile 
    1265                 1270                 1275             


Gln Glu  Ser Glu His Met Lys  Val Glu Asn Ser Glu  Asn Gly Ser 
    1280                 1285                 1290             


Lys Leu  Thr Ile Leu Ala Ala  Arg Gln Glu His Cys  Gly Cys Tyr 
    1295                 1300                 1305             


Thr Leu  Leu Val Glu Asn Lys  Leu Gly Ser Arg Gln  Ala Gln Val 
    1310                 1315                 1320             


Asn Leu  Thr Val Val Asp Lys  Pro Asp Pro Pro Ala  Gly Thr Pro 
    1325                 1330                 1335             


Cys Ala  Ser Asp Ile Arg Ser  Ser Ser Leu Thr Leu  Ser Trp Tyr 
    1340                 1345                 1350             


Gly Ser  Ser Tyr Asp Gly Gly  Ser Ala Val Gln Ser  Tyr Ser Ile 
    1355                 1360                 1365             


Glu Ile  Trp Asp Ser Ala Asn  Lys Thr Trp Lys Glu  Leu Ala Thr 
    1370                 1375                 1380             


Cys Arg  Ser Thr Ser Phe Asn  Val Gln Asp Leu Leu  Pro Asp His 
    1385                 1390                 1395             


Glu Tyr  Lys Phe Arg Val Arg  Ala Ile Asn Val Tyr  Gly Thr Ser 
    1400                 1405                 1410             


Glu Pro  Ser Gln Glu Ser Glu  Leu Thr Thr Val Gly  Glu Lys Pro 
    1415                 1420                 1425             


Glu Glu  Pro Lys Asp Glu Val  Glu Val Ser Asp Asp  Asp Glu Lys 
    1430                 1435                 1440             


Glu Pro  Glu Val Asp Tyr Arg  Thr Val Thr Ile Asn  Thr Glu Gln 
    1445                 1450                 1455             


Lys Val  Ser Asp Phe Tyr Asp  Ile Glu Glu Arg Leu  Gly Ser Gly 
    1460                 1465                 1470             


Lys Phe  Gly Gln Val Phe Arg  Leu Val Glu Lys Lys  Thr Arg Lys 
    1475                 1480                 1485             


Val Trp  Ala Gly Lys Phe Phe  Lys Ala Tyr Ser Ala  Lys Glu Lys 
    1490                 1495                 1500             


Glu Asn  Ile Arg Gln Glu Ile  Ser Ile Met Asn Cys  Leu His His 
    1505                 1510                 1515             


Pro Lys  Leu Val Gln Cys Val  Asp Ala Phe Glu Glu  Lys Ala Asn 
    1520                 1525                 1530             


Ile Val  Met Val Leu Glu Ile  Val Ser Gly Gly Glu  Leu Phe Glu 
    1535                 1540                 1545             


Arg Ile  Ile Asp Glu Asp Phe  Glu Leu Thr Glu Arg  Glu Cys Ile 
    1550                 1555                 1560             


Lys Tyr  Met Arg Gln Ile Ser  Glu Gly Val Glu Tyr  Ile His Lys 
    1565                 1570                 1575             


Gln Gly  Ile Val His Leu Asp  Leu Lys Pro Glu Asn  Ile Met Cys 
    1580                 1585                 1590             


Val Asn  Lys Thr Gly Thr Arg  Ile Lys Leu Ile Asp  Phe Gly Leu 
    1595                 1600                 1605             


Ala Arg  Arg Leu Glu Asn Ala  Gly Ser Leu Lys Val  Leu Phe Gly 
    1610                 1615                 1620             


Thr Pro  Glu Phe Val Ala Pro  Glu Val Ile Asn Tyr  Glu Pro Ile 
    1625                 1630                 1635             


Gly Tyr  Ala Thr Asp Met Trp  Ser Ile Gly Val Ile  Cys Tyr Ile 
    1640                 1645                 1650             


Leu Val  Ser Gly Leu Ser Pro  Phe Met Gly Asp Asn  Asp Asn Glu 
    1655                 1660                 1665             


Thr Leu  Ala Asn Val Thr Ser  Ala Thr Trp Asp Phe  Asp Asp Glu 
    1670                 1675                 1680             


Ala Phe  Asp Glu Ile Ser Asp  Asp Ala Lys Asp Phe  Ile Ser Asn 
    1685                 1690                 1695             


Leu Leu  Lys Lys Asp Met Lys  Asn Arg Leu Asp Cys  Thr Gln Cys 
    1700                 1705                 1710             


Leu Gln  His Pro Trp Leu Met  Lys Asp Thr Lys Asn  Met Glu Ala 
    1715                 1720                 1725             


Lys Lys  Leu Ser Lys Asp Arg  Met Lys Lys Tyr Met  Ala Arg Arg 
    1730                 1735                 1740             


Lys Trp  Gln Lys Thr Gly Asn  Ala Val Arg Ala Ile  Gly Arg Leu 
    1745                 1750                 1755             


Ser Ser  Met Ala Met Ile Ser  Gly Leu Ser Gly Arg  Lys Ser Ser 
    1760                 1765                 1770             


Thr Gly  Ser Pro Thr Ser Pro  Leu Asn Ala Glu Lys  Leu Glu Ser 
    1775                 1780                 1785             


Glu Glu  Asp Val Ser Gln Ala  Phe Leu Glu Ala Val  Ala Glu Glu 
    1790                 1795                 1800             


Lys Pro  His Val Lys Pro Tyr  Phe Ser Lys Thr Ile  Arg Asp Leu 
    1805                 1810                 1815             


Glu Val  Val Glu Gly Ser Ala  Ala Arg Phe Asp Cys  Lys Ile Glu 
    1820                 1825                 1830             


Gly Tyr  Pro Asp Pro Glu Val  Val Trp Phe Lys Asp  Asp Gln Ser 
    1835                 1840                 1845             


Ile Arg  Glu Ser Arg His Phe  Gln Ile Asp Tyr Asp  Glu Asp Gly 
    1850                 1855                 1860             


Asn Cys  Ser Leu Ile Ile Ser  Asp Val Cys Gly Asp  Asp Asp Ala 
    1865                 1870                 1875             


Lys Tyr  Thr Cys Lys Ala Val  Asn Ser Leu Gly Glu  Ala Thr Cys 
    1880                 1885                 1890             


Thr Ala  Glu Leu Ile Val Glu  Thr Met Glu Glu Gly  Glu Gly Glu 
    1895                 1900                 1905             


Gly Glu  Glu Glu Glu Glu 
    1910                 


<210>  208
<211>  329
<212>  PRT
<213>  Homo sapiens

<400>  208

Met Ala Glu Ala Gly Thr Gly Glu Pro Ser Pro Ser Val Glu Gly Glu 
1               5                   10                  15      


His Gly Thr Glu Tyr Asp Thr Leu Pro Ser Asp Thr Val Ser Leu Ser 
            20                  25                  30          


Asp Ser Asp Ser Asp Leu Ser Leu Pro Gly Gly Ala Glu Val Glu Ala 
        35                  40                  45              


Leu Ser Pro Met Gly Leu Pro Gly Glu Glu Asp Ser Gly Pro Asp Glu 
    50                  55                  60                  


Pro Pro Ser Pro Pro Ser Gly Leu Leu Pro Ala Thr Val Gln Pro Phe 
65                  70                  75                  80  


His Leu Arg Gly Met Ser Ser Thr Phe Ser Gln Arg Ser Arg Asp Ile 
                85                  90                  95      


Phe Asp Cys Leu Glu Gly Ala Ala Arg Arg Ala Pro Ser Ser Val Ala 
            100                 105                 110         


His Thr Ser Met Ser Asp Asn Gly Gly Phe Lys Arg Pro Leu Ala Pro 
        115                 120                 125             


Ser Gly Arg Ser Pro Val Glu Gly Leu Gly Arg Ala His Arg Ser Pro 
    130                 135                 140                 


Ala Ser Pro Arg Val Pro Pro Val Pro Asp Tyr Val Ala His Pro Glu 
145                 150                 155                 160 


Arg Trp Thr Lys Tyr Ser Leu Glu Asp Val Thr Glu Val Ser Glu Gln 
                165                 170                 175     


Ser Asn Gln Ala Thr Ala Leu Ala Phe Leu Gly Ser Gln Ser Leu Ala 
            180                 185                 190         


Ala Pro Thr Asp Cys Val Ser Ser Phe Asn Gln Asp Pro Ser Ser Cys 
        195                 200                 205             


Gly Glu Gly Arg Val Ile Phe Thr Lys Pro Val Arg Gly Val Glu Ala 
    210                 215                 220                 


Arg His Glu Arg Lys Arg Val Leu Gly Lys Val Gly Glu Pro Gly Arg 
225                 230                 235                 240 


Gly Gly Leu Gly Asn Pro Ala Thr Asp Arg Gly Glu Gly Pro Val Glu 
                245                 250                 255     


Leu Ala His Leu Ala Gly Pro Gly Ser Pro Glu Ala Glu Glu Trp Gly 
            260                 265                 270         


Ser Pro His Gly Gly Leu Gln Glu Val Glu Ala Leu Ser Gly Ser Val 
        275                 280                 285             


His Ser Gly Ser Val Pro Gly Leu Pro Pro Val Glu Thr Val Gly Phe 
    290                 295                 300                 


His Gly Ser Arg Lys Arg Ser Arg Asp His Phe Arg Asn Lys Ser Ser 
305                 310                 315                 320 


Ser Pro Glu Asp Pro Gly Ala Glu Val 
                325                 


<210>  209
<211>  514
<212>  PRT
<213>  Homo sapiens

<400>  209

Met Tyr Ser Gln Arg Phe Gly Thr Val Gln Arg Glu Val Lys Gly Pro 
1               5                   10                  15      


Thr Pro Lys Val Val Ile Val Arg Ser Lys Pro Pro Lys Gly Gln Gly 
            20                  25                  30          


Ala Glu His His Leu Glu Arg Ile Arg Arg Ser His Gln Lys His Asn 
        35                  40                  45              


Ala Ile Leu Ala Ser Ile Lys Ser Ser Glu Arg Asp Arg Leu Lys Ala 
    50                  55                  60                  


Glu Trp Asp Gln His Asn Asp Cys Lys Ile Leu Asp Ser Leu Val Arg 
65                  70                  75                  80  


Ala Arg Ile Lys Asp Ala Val Gln Gly Phe Ile Ile Asn Ile Glu Glu 
                85                  90                  95      


Arg Arg Asn Lys Leu Arg Glu Leu Leu Ala Leu Glu Glu Asn Glu Tyr 
            100                 105                 110         


Phe Thr Glu Met Gln Leu Lys Lys Glu Thr Ile Glu Glu Lys Lys Asp 
        115                 120                 125             


Arg Met Arg Glu Lys Thr Lys Leu Leu Lys Glu Lys Asn Glu Lys Glu 
    130                 135                 140                 


Arg Gln Asp Phe Val Ala Glu Lys Leu Asp Gln Gln Phe Arg Glu Arg 
145                 150                 155                 160 


Cys Glu Glu Leu Arg Val Glu Leu Leu Ser Ile His Gln Lys Lys Val 
                165                 170                 175     


Cys Glu Glu Arg Lys Ala Gln Ile Ala Phe Asn Glu Glu Leu Ser Arg 
            180                 185                 190         


Gln Lys Leu Val Glu Glu Gln Met Phe Ser Lys Leu Trp Glu Glu Asp 
        195                 200                 205             


Arg Leu Ala Lys Glu Lys Arg Glu Ala Gln Glu Ala Arg Arg Gln Lys 
    210                 215                 220                 


Glu Leu Met Glu Asn Thr Arg Leu Gly Leu Asn Ala Gln Ile Thr Ser 
225                 230                 235                 240 


Ile Lys Ala Gln Arg Gln Ala Thr Gln Leu Leu Lys Glu Glu Glu Ala 
                245                 250                 255     


Arg Leu Val Glu Ser Asn Asn Ala Gln Ile Lys His Glu Asn Glu Gln 
            260                 265                 270         


Asp Met Leu Lys Lys Gln Lys Ala Lys Gln Glu Thr Arg Thr Ile Leu 
        275                 280                 285             


Gln Lys Ala Leu Gln Glu Arg Ile Glu His Ile Gln Gln Glu Tyr Arg 
    290                 295                 300                 


Asp Glu Gln Asp Leu Asn Met Lys Leu Val Gln Arg Ala Leu Gln Asp 
305                 310                 315                 320 


Leu Gln Glu Glu Ala Asp Lys Lys Lys Gln Lys Arg Glu Asp Met Ile 
                325                 330                 335     


Arg Glu Gln Lys Ile Tyr His Lys Tyr Leu Ala Gln Arg Arg Glu Glu 
            340                 345                 350         


Glu Lys Ala Gln Glu Lys Glu Phe Asp Arg Ile Leu Glu Glu Asp Lys 
        355                 360                 365             


Ala Lys Lys Leu Ala Glu Lys Asp Lys Glu Leu Arg Leu Glu Lys Glu 
    370                 375                 380                 


Ala Arg Arg Gln Leu Val Asp Glu Val Met Cys Thr Arg Lys Leu Gln 
385                 390                 395                 400 


Val Gln Glu Lys Leu Gln Arg Glu Ala Lys Glu Gln Glu Glu Arg Ala 
                405                 410                 415     


Met Glu Gln Lys His Ile Asn Glu Ser Leu Lys Glu Leu Asn Cys Glu 
            420                 425                 430         


Glu Lys Glu Asn Phe Ala Arg Arg Gln Arg Leu Ala Gln Glu Tyr Arg 
        435                 440                 445             


Lys Gln Leu Gln Met Gln Ile Ala Tyr Gln Gln Gln Ser Gln Glu Ala 
    450                 455                 460                 


Glu Lys Glu Glu Lys Arg Arg Glu Phe Glu Ala Gly Val Ala Ala Asn 
465                 470                 475                 480 


Lys Met Cys Leu Asp Lys Val Gln Glu Val Leu Ser Thr His Gln Val 
                485                 490                 495     


Leu Pro Gln Asn Ile His Pro Met Arg Lys Ala Cys Pro Ser Lys Leu 
            500                 505                 510         


Pro Pro 
        


<210>  210
<211>  500
<212>  PRT
<213>  Homo sapiens

<400>  210

Met Ser Ser Asp Asp Arg His Leu Gly Ser Ser Cys Gly Ser Phe Ile 
1               5                   10                  15      


Lys Thr Glu Pro Ser Ser Pro Ser Ser Gly Ile Asp Ala Leu Ser His 
            20                  25                  30          


His Ser Pro Ser Gly Ser Ser Asp Ala Ser Gly Gly Phe Gly Leu Ala 
        35                  40                  45              


Leu Gly Thr His Ala Asn Gly Leu Asp Ser Pro Pro Met Phe Ala Gly 
    50                  55                  60                  


Ala Gly Leu Gly Gly Thr Pro Cys Arg Lys Ser Tyr Glu Asp Cys Ala 
65                  70                  75                  80  


Ser Gly Ile Met Glu Asp Ser Ala Ile Lys Cys Glu Tyr Met Leu Asn 
                85                  90                  95      


Ala Ile Pro Lys Arg Leu Cys Leu Val Cys Gly Asp Ile Ala Ser Gly 
            100                 105                 110         


Tyr His Tyr Gly Val Ala Ser Cys Glu Ala Cys Lys Ala Phe Phe Lys 
        115                 120                 125             


Arg Thr Ile Gln Gly Asn Ile Glu Tyr Ser Cys Pro Ala Thr Asn Glu 
    130                 135                 140                 


Cys Glu Ile Thr Lys Arg Arg Arg Lys Ser Cys Gln Ala Cys Arg Phe 
145                 150                 155                 160 


Met Lys Cys Leu Lys Val Gly Met Leu Lys Glu Gly Val Arg Leu Asp 
                165                 170                 175     


Arg Val Arg Gly Gly Arg Gln Lys Tyr Lys Arg Arg Leu Asp Ser Glu 
            180                 185                 190         


Ser Ser Pro Tyr Leu Ser Leu Gln Ile Ser Pro Pro Ala Lys Lys Pro 
        195                 200                 205             


Leu Thr Lys Ile Val Ser Tyr Leu Leu Val Ala Glu Pro Asp Lys Leu 
    210                 215                 220                 


Tyr Ala Met Pro Pro Pro Gly Met Pro Glu Gly Asp Ile Lys Ala Leu 
225                 230                 235                 240 


Thr Thr Leu Cys Asp Leu Ala Asp Arg Glu Leu Val Val Ile Ile Gly 
                245                 250                 255     


Trp Ala Lys His Ile Pro Gly Phe Ser Ser Leu Ser Leu Gly Asp Gln 
            260                 265                 270         


Met Ser Leu Leu Gln Ser Ala Trp Met Glu Ile Leu Ile Leu Gly Ile 
        275                 280                 285             


Val Tyr Arg Ser Leu Pro Tyr Asp Asp Lys Leu Val Tyr Ala Glu Asp 
    290                 295                 300                 


Tyr Ile Met Asp Glu Glu His Ser Arg Leu Ala Gly Leu Leu Glu Leu 
305                 310                 315                 320 


Tyr Arg Ala Ile Leu Gln Leu Val Arg Arg Tyr Lys Lys Leu Lys Val 
                325                 330                 335     


Glu Lys Glu Glu Phe Val Thr Leu Lys Ala Leu Ala Leu Ala Asn Ser 
            340                 345                 350         


Asp Ser Met Tyr Ile Glu Asp Leu Glu Ala Val Gln Lys Leu Gln Asp 
        355                 360                 365             


Leu Leu His Glu Ala Leu Gln Asp Tyr Glu Leu Ser Gln Arg His Glu 
    370                 375                 380                 


Glu Pro Trp Arg Thr Gly Lys Leu Leu Leu Thr Leu Pro Leu Leu Arg 
385                 390                 395                 400 


Gln Thr Ala Ala Lys Ala Val Gln His Phe Tyr Ser Val Lys Leu Gln 
                405                 410                 415     


Gly Lys Val Pro Met His Lys Leu Phe Leu Glu Met Leu Glu Ala Lys 
            420                 425                 430         


Ala Trp Ala Arg Ala Asp Ser Leu Gln Glu Trp Arg Pro Leu Glu Gln 
        435                 440                 445             


Val Pro Ser Pro Leu His Arg Ala Thr Lys Arg Gln His Val His Phe 
    450                 455                 460                 


Leu Thr Pro Leu Pro Pro Pro Pro Ser Val Ala Trp Val Gly Thr Ala 
465                 470                 475                 480 


Gln Ala Gly Tyr His Leu Glu Val Phe Leu Pro Gln Arg Ala Gly Trp 
                485                 490                 495     


Pro Arg Ala Ala 
            500 


<210>  211
<211>  1210
<212>  PRT
<213>  Homo sapiens

<400>  211

Met Arg Pro Ser Gly Thr Ala Gly Ala Ala Leu Leu Ala Leu Leu Ala 
1               5                   10                  15      


Ala Leu Cys Pro Ala Ser Arg Ala Leu Glu Glu Lys Lys Val Cys Gln 
            20                  25                  30          


Gly Thr Ser Asn Lys Leu Thr Gln Leu Gly Thr Phe Glu Asp His Phe 
        35                  40                  45              


Leu Ser Leu Gln Arg Met Phe Asn Asn Cys Glu Val Val Leu Gly Asn 
    50                  55                  60                  


Leu Glu Ile Thr Tyr Val Gln Arg Asn Tyr Asp Leu Ser Phe Leu Lys 
65                  70                  75                  80  


Thr Ile Gln Glu Val Ala Gly Tyr Val Leu Ile Ala Leu Asn Thr Val 
                85                  90                  95      


Glu Arg Ile Pro Leu Glu Asn Leu Gln Ile Ile Arg Gly Asn Met Tyr 
            100                 105                 110         


Tyr Glu Asn Ser Tyr Ala Leu Ala Val Leu Ser Asn Tyr Asp Ala Asn 
        115                 120                 125             


Lys Thr Gly Leu Lys Glu Leu Pro Met Arg Asn Leu Gln Glu Ile Leu 
    130                 135                 140                 


His Gly Ala Val Arg Phe Ser Asn Asn Pro Ala Leu Cys Asn Val Glu 
145                 150                 155                 160 


Ser Ile Gln Trp Arg Asp Ile Val Ser Ser Asp Phe Leu Ser Asn Met 
                165                 170                 175     


Ser Met Asp Phe Gln Asn His Leu Gly Ser Cys Gln Lys Cys Asp Pro 
            180                 185                 190         


Ser Cys Pro Asn Gly Ser Cys Trp Gly Ala Gly Glu Glu Asn Cys Gln 
        195                 200                 205             


Lys Leu Thr Lys Ile Ile Cys Ala Gln Gln Cys Ser Gly Arg Cys Arg 
    210                 215                 220                 


Gly Lys Ser Pro Ser Asp Cys Cys His Asn Gln Cys Ala Ala Gly Cys 
225                 230                 235                 240 


Thr Gly Pro Arg Glu Ser Asp Cys Leu Val Cys Arg Lys Phe Arg Asp 
                245                 250                 255     


Glu Ala Thr Cys Lys Asp Thr Cys Pro Pro Leu Met Leu Tyr Asn Pro 
            260                 265                 270         


Thr Thr Tyr Gln Met Asp Val Asn Pro Glu Gly Lys Tyr Ser Phe Gly 
        275                 280                 285             


Ala Thr Cys Val Lys Lys Cys Pro Arg Asn Tyr Val Val Thr Asp His 
    290                 295                 300                 


Gly Ser Cys Val Arg Ala Cys Gly Ala Asp Ser Tyr Glu Met Glu Glu 
305                 310                 315                 320 


Asp Gly Val Arg Lys Cys Lys Lys Cys Glu Gly Pro Cys Arg Lys Val 
                325                 330                 335     


Cys Asn Gly Ile Gly Ile Gly Glu Phe Lys Asp Ser Leu Ser Ile Asn 
            340                 345                 350         


Ala Thr Asn Ile Lys His Phe Lys Asn Cys Thr Ser Ile Ser Gly Asp 
        355                 360                 365             


Leu His Ile Leu Pro Val Ala Phe Arg Gly Asp Ser Phe Thr His Thr 
    370                 375                 380                 


Pro Pro Leu Asp Pro Gln Glu Leu Asp Ile Leu Lys Thr Val Lys Glu 
385                 390                 395                 400 


Ile Thr Gly Phe Leu Leu Ile Gln Ala Trp Pro Glu Asn Arg Thr Asp 
                405                 410                 415     


Leu His Ala Phe Glu Asn Leu Glu Ile Ile Arg Gly Arg Thr Lys Gln 
            420                 425                 430         


His Gly Gln Phe Ser Leu Ala Val Val Ser Leu Asn Ile Thr Ser Leu 
        435                 440                 445             


Gly Leu Arg Ser Leu Lys Glu Ile Ser Asp Gly Asp Val Ile Ile Ser 
    450                 455                 460                 


Gly Asn Lys Asn Leu Cys Tyr Ala Asn Thr Ile Asn Trp Lys Lys Leu 
465                 470                 475                 480 


Phe Gly Thr Ser Gly Gln Lys Thr Lys Ile Ile Ser Asn Arg Gly Glu 
                485                 490                 495     


Asn Ser Cys Lys Ala Thr Gly Gln Val Cys His Ala Leu Cys Ser Pro 
            500                 505                 510         


Glu Gly Cys Trp Gly Pro Glu Pro Arg Asp Cys Val Ser Cys Arg Asn 
        515                 520                 525             


Val Ser Arg Gly Arg Glu Cys Val Asp Lys Cys Asn Leu Leu Glu Gly 
    530                 535                 540                 


Glu Pro Arg Glu Phe Val Glu Asn Ser Glu Cys Ile Gln Cys His Pro 
545                 550                 555                 560 


Glu Cys Leu Pro Gln Ala Met Asn Ile Thr Cys Thr Gly Arg Gly Pro 
                565                 570                 575     


Asp Asn Cys Ile Gln Cys Ala His Tyr Ile Asp Gly Pro His Cys Val 
            580                 585                 590         


Lys Thr Cys Pro Ala Gly Val Met Gly Glu Asn Asn Thr Leu Val Trp 
        595                 600                 605             


Lys Tyr Ala Asp Ala Gly His Val Cys His Leu Cys His Pro Asn Cys 
    610                 615                 620                 


Thr Tyr Gly Cys Thr Gly Pro Gly Leu Glu Gly Cys Pro Thr Asn Gly 
625                 630                 635                 640 


Pro Lys Ile Pro Ser Ile Ala Thr Gly Met Val Gly Ala Leu Leu Leu 
                645                 650                 655     


Leu Leu Val Val Ala Leu Gly Ile Gly Leu Phe Met Arg Arg Arg His 
            660                 665                 670         


Ile Val Arg Lys Arg Thr Leu Arg Arg Leu Leu Gln Glu Arg Glu Leu 
        675                 680                 685             


Val Glu Pro Leu Thr Pro Ser Gly Glu Ala Pro Asn Gln Ala Leu Leu 
    690                 695                 700                 


Arg Ile Leu Lys Glu Thr Glu Phe Lys Lys Ile Lys Val Leu Gly Ser 
705                 710                 715                 720 


Gly Ala Phe Gly Thr Val Tyr Lys Gly Leu Trp Ile Pro Glu Gly Glu 
                725                 730                 735     


Lys Val Lys Ile Pro Val Ala Ile Lys Glu Leu Arg Glu Ala Thr Ser 
            740                 745                 750         


Pro Lys Ala Asn Lys Glu Ile Leu Asp Glu Ala Tyr Val Met Ala Ser 
        755                 760                 765             


Val Asp Asn Pro His Val Cys Arg Leu Leu Gly Ile Cys Leu Thr Ser 
    770                 775                 780                 


Thr Val Gln Leu Ile Thr Gln Leu Met Pro Phe Gly Cys Leu Leu Asp 
785                 790                 795                 800 


Tyr Val Arg Glu His Lys Asp Asn Ile Gly Ser Gln Tyr Leu Leu Asn 
                805                 810                 815     


Trp Cys Val Gln Ile Ala Lys Gly Met Asn Tyr Leu Glu Asp Arg Arg 
            820                 825                 830         


Leu Val His Arg Asp Leu Ala Ala Arg Asn Val Leu Val Lys Thr Pro 
        835                 840                 845             


Gln His Val Lys Ile Thr Asp Phe Gly Arg Ala Lys Leu Leu Gly Ala 
    850                 855                 860                 


Glu Glu Lys Glu Tyr His Ala Glu Gly Gly Lys Val Pro Ile Lys Trp 
865                 870                 875                 880 


Met Ala Leu Glu Ser Ile Leu His Arg Ile Tyr Thr His Gln Ser Asp 
                885                 890                 895     


Val Trp Ser Tyr Gly Val Thr Val Trp Glu Leu Met Thr Phe Gly Ser 
            900                 905                 910         


Lys Pro Tyr Asp Gly Ile Pro Ala Ser Glu Ile Ser Ser Ile Leu Glu 
        915                 920                 925             


Lys Gly Glu Arg Leu Pro Gln Pro Pro Ile Cys Thr Ile Asp Val Tyr 
    930                 935                 940                 


Met Ile Met Val Lys Cys Trp Met Ile Asp Ala Asp Ser Arg Pro Lys 
945                 950                 955                 960 


Phe Arg Glu Leu Ile Ile Glu Phe Ser Lys Met Ala Arg Asp Pro Gln 
                965                 970                 975     


Arg Tyr Leu Val Ile Gln Gly Asp Glu Arg Met His Leu Pro Ser Pro 
            980                 985                 990         


Thr Asp Ser Asn Phe Tyr Arg Ala  Leu Met Asp Glu Glu  Asp Met Asp 
        995                 1000                 1005             


Asp Val  Val Asp Ala Asp Glu  Tyr Leu Ile Pro Gln  Gln Gly Phe 
    1010                 1015                 1020             


Phe Ser  Ser Pro Ser Thr Ser  Arg Thr Pro Leu Leu  Ser Ser Leu 
    1025                 1030                 1035             


Ser Ala  Thr Ser Asn Asn Ser  Thr Val Ala Cys Ile  Asp Arg Asn 
    1040                 1045                 1050             


Gly Leu  Gln Ser Cys Pro Ile  Lys Glu Asp Ser Phe  Leu Gln Arg 
    1055                 1060                 1065             


Tyr Ser  Ser Asp Pro Thr Gly  Ala Leu Thr Glu Asp  Ser Ile Asp 
    1070                 1075                 1080             


Asp Thr  Phe Leu Pro Val Pro  Glu Tyr Ile Asn Gln  Ser Val Pro 
    1085                 1090                 1095             


Lys Arg  Pro Ala Gly Ser Val  Gln Asn Pro Val Tyr  His Asn Gln 
    1100                 1105                 1110             


Pro Leu  Asn Pro Ala Pro Ser  Arg Asp Pro His Tyr  Gln Asp Pro 
    1115                 1120                 1125             


His Ser  Thr Ala Val Gly Asn  Pro Glu Tyr Leu Asn  Thr Val Gln 
    1130                 1135                 1140             


Pro Thr  Cys Val Asn Ser Thr  Phe Asp Ser Pro Ala  His Trp Ala 
    1145                 1150                 1155             


Gln Lys  Gly Ser His Gln Ile  Ser Leu Asp Asn Pro  Asp Tyr Gln 
    1160                 1165                 1170             


Gln Asp  Phe Phe Pro Lys Glu  Ala Lys Pro Asn Gly  Ile Phe Lys 
    1175                 1180                 1185             


Gly Ser  Thr Ala Glu Asn Ala  Glu Tyr Leu Arg Val  Ala Pro Gln 
    1190                 1195                 1200             


Ser Ser  Glu Phe Ile Gly Ala  
    1205                 1210 


<210>  212
<211>  2028
<212>  PRT
<213>  Homo sapiens

<400>  212

Met Asp Val Thr Val Ser Glu Leu Leu Glu Leu Phe Leu Gln Ser Pro 
1               5                   10                  15      


Leu Val Thr Trp Val Lys Thr Phe Gly Pro Phe Gly Ser Gly Ser Gln 
            20                  25                  30          


Asp Asn Leu Thr Met Tyr Met Asp Leu Val Asp Gly Ile Phe Leu Asn 
        35                  40                  45              


Gln Ile Met Leu Gln Ile Asp Pro Arg Pro Thr Asn Gln Arg Ile Asn 
    50                  55                  60                  


Lys His Val Asn Asn Asp Val Asn Leu Arg Ile Gln Asn Leu Thr Ile 
65                  70                  75                  80  


Leu Val Arg Asn Ile Lys Thr Tyr Tyr Gln Glu Val Leu Gln Gln Leu 
                85                  90                  95      


Ile Val Met Asn Leu Pro Asn Val Leu Met Ile Gly Arg Asp Pro Leu 
            100                 105                 110         


Ser Gly Lys Ser Met Glu Glu Ile Lys Lys Val Leu Leu Leu Val Leu 
        115                 120                 125             


Gly Cys Ala Val Gln Cys Glu Arg Lys Glu Glu Phe Ile Glu Arg Ile 
    130                 135                 140                 


Lys Gln Leu Asp Ile Glu Thr Gln Ala Gly Ile Val Ala His Ile Gln 
145                 150                 155                 160 


Glu Val Thr His Asn Gln Glu Asn Val Phe Asp Leu Gln Trp Leu Glu 
                165                 170                 175     


Leu Pro Asp Val Ala Pro Glu Glu Leu Glu Ala Leu Ser Arg Ser Met 
            180                 185                 190         


Val Leu His Leu Arg Arg Leu Ile Asp Gln Arg Asp Glu Cys Thr Glu 
        195                 200                 205             


Leu Ile Val Asp Leu Thr Gln Glu Arg Asp Tyr Leu Gln Ala Gln His 
    210                 215                 220                 


Pro Pro Ser Pro Ile Lys Ser Ser Ser Ala Asp Ser Thr Pro Ser Pro 
225                 230                 235                 240 


Thr Ser Ser Leu Ser Ser Glu Asp Lys Gln His Leu Ala Val Glu Leu 
                245                 250                 255     


Ala Asp Thr Lys Ala Arg Leu Arg Arg Val Arg Gln Glu Leu Glu Asp 
            260                 265                 270         


Lys Thr Glu Gln Leu Val Asp Thr Arg His Glu Val Asp Gln Leu Val 
        275                 280                 285             


Leu Glu Leu Gln Lys Val Lys Gln Glu Asn Ile Gln Leu Ala Ala Asp 
    290                 295                 300                 


Ala Arg Ser Ala Arg Ala Tyr Arg Asp Glu Leu Asp Ser Leu Arg Glu 
305                 310                 315                 320 


Lys Ala Asn Arg Val Glu Arg Leu Glu Leu Glu Leu Thr Arg Cys Lys 
                325                 330                 335     


Glu Lys Leu His Asp Val Asp Phe Tyr Lys Ala Arg Met Glu Glu Leu 
            340                 345                 350         


Arg Glu Asp Asn Ile Ile Leu Ile Glu Thr Lys Ala Met Leu Glu Glu 
        355                 360                 365             


Gln Leu Thr Ala Ala Arg Ala Arg Gly Asp Lys Val His Glu Leu Glu 
    370                 375                 380                 


Lys Glu Asn Leu Gln Leu Lys Ser Lys Leu His Asp Leu Glu Leu Asp 
385                 390                 395                 400 


Arg Asp Thr Asp Lys Lys Arg Ile Glu Glu Leu Leu Glu Glu Asn Met 
                405                 410                 415     


Val Leu Glu Ile Ala Gln Lys Gln Ser Met Asn Glu Ser Ala His Leu 
            420                 425                 430         


Gly Trp Glu Leu Glu Gln Leu Ser Lys Asn Ala Asp Leu Ser Asp Ala 
        435                 440                 445             


Ser Arg Lys Ser Phe Val Phe Glu Leu Asn Glu Cys Ala Ser Ser Arg 
    450                 455                 460                 


Ile Leu Lys Leu Glu Lys Glu Asn Gln Ser Leu Gln Ser Thr Ile Gln 
465                 470                 475                 480 


Gly Leu Arg Asp Ala Ser Leu Val Leu Glu Glu Ser Gly Leu Lys Cys 
                485                 490                 495     


Gly Glu Leu Glu Lys Glu Asn His Gln Leu Ser Lys Lys Ile Glu Lys 
            500                 505                 510         


Leu Gln Thr Gln Leu Glu Arg Glu Lys Gln Ser Asn Gln Asp Leu Glu 
        515                 520                 525             


Thr Leu Ser Glu Glu Leu Ile Arg Glu Lys Glu Gln Leu Gln Ser Asp 
    530                 535                 540                 


Met Glu Thr Leu Lys Ala Asp Lys Ala Arg Gln Ile Lys Asp Leu Glu 
545                 550                 555                 560 


Gln Glu Lys Asp His Leu Asn Arg Ala Met Trp Ser Leu Arg Glu Arg 
                565                 570                 575     


Ser Gln Val Ser Ser Glu Ala Arg Met Lys Asp Val Glu Lys Glu Asn 
            580                 585                 590         


Lys Ala Leu His Gln Thr Val Thr Glu Ala Asn Gly Lys Leu Ser Gln 
        595                 600                 605             


Leu Glu Phe Glu Lys Arg Gln Leu His Arg Asp Leu Glu Gln Ala Lys 
    610                 615                 620                 


Glu Lys Gly Glu Arg Ala Glu Lys Leu Glu Arg Glu Leu Gln Arg Leu 
625                 630                 635                 640 


Gln Glu Glu Asn Gly Arg Leu Ala Arg Lys Val Thr Ser Leu Glu Thr 
                645                 650                 655     


Ala Thr Glu Lys Val Glu Ala Leu Glu His Glu Ser Gln Gly Leu Gln 
            660                 665                 670         


Leu Glu Asn Arg Thr Leu Arg Lys Ser Leu Asp Thr Leu Gln Asn Val 
        675                 680                 685             


Ser Leu Gln Leu Glu Gly Leu Glu Arg Asp Asn Lys Gln Leu Asp Ala 
    690                 695                 700                 


Glu Asn Leu Glu Leu Arg Arg Leu Val Glu Thr Met Arg Phe Thr Ser 
705                 710                 715                 720 


Thr Lys Leu Ala Gln Met Glu Arg Glu Asn Gln Gln Leu Glu Arg Glu 
                725                 730                 735     


Lys Glu Glu Leu Arg Lys Asn Val Asp Leu Leu Lys Ala Leu Gly Lys 
            740                 745                 750         


Lys Ser Glu Arg Leu Glu Leu Ser Tyr Gln Ser Val Ser Ala Glu Asn 
        755                 760                 765             


Leu Arg Leu Gln Gln Ser Leu Glu Ser Ser Ser His Lys Thr Gln Thr 
    770                 775                 780                 


Leu Glu Ser Glu Leu Gly Glu Leu Glu Ala Glu Arg Gln Ala Leu Arg 
785                 790                 795                 800 


Arg Asp Leu Glu Ala Leu Arg Leu Ala Asn Ala Gln Leu Glu Gly Ala 
                805                 810                 815     


Glu Lys Asp Arg Lys Ala Leu Glu Gln Glu Val Ala Gln Leu Glu Lys 
            820                 825                 830         


Asp Lys Lys Leu Leu Glu Lys Glu Ala Lys Arg Leu Trp Gln Gln Val 
        835                 840                 845             


Glu Leu Lys Asp Ala Val Leu Asp Asp Ser Thr Ala Lys Leu Ser Ala 
    850                 855                 860                 


Val Glu Lys Glu Ser Arg Ala Leu Asp Lys Glu Leu Ala Arg Cys Arg 
865                 870                 875                 880 


Asp Ala Ala Gly Lys Leu Lys Glu Leu Glu Lys Asp Asn Arg Asp Leu 
                885                 890                 895     


Thr Lys Gln Val Thr Val His Ala Arg Thr Leu Thr Thr Leu Arg Glu 
            900                 905                 910         


Asp Leu Val Leu Glu Lys Leu Lys Ser Gln Gln Leu Ser Ser Glu Leu 
        915                 920                 925             


Asp Lys Leu Ser Gln Glu Leu Glu Lys Val Gly Leu Asn Arg Glu Leu 
    930                 935                 940                 


Leu Leu Gln Glu Asp Asp Ser Gly Ser Asp Thr Lys Tyr Lys Ile Leu 
945                 950                 955                 960 


Glu Gly Arg Asn Glu Ser Ala Leu Lys Thr Thr Leu Ala Met Lys Glu 
                965                 970                 975     


Glu Lys Ile Val Leu Leu Glu Ala Gln Met Glu Glu Lys Ala Ser Leu 
            980                 985                 990         


Asn Arg Gln Leu Glu Ser Glu Leu  Gln Met Leu Lys Lys  Glu Cys Glu 
        995                 1000                 1005             


Thr Leu  Arg Gln Asn Gln Gly  Glu Gly Gln His Leu  Gln Asn Ser 
    1010                 1015                 1020             


Phe Lys  His Pro Ala Gly Lys  Thr Ala Ala Ser His  Gln Gly Lys 
    1025                 1030                 1035             


Glu Ala  Trp Gly Pro Gly His  Lys Glu Ala Thr Met  Glu Leu Leu 
    1040                 1045                 1050             


Arg Val  Lys Asp Arg Ala Ile  Glu Leu Glu Arg Asn  Asn Ala Ala 
    1055                 1060                 1065             


Leu Gln  Ala Glu Lys Gln Leu  Leu Lys Glu Gln Leu  Gln His Leu 
    1070                 1075                 1080             


Glu Thr  Gln Asn Val Thr Phe  Ser Ser Gln Ile Leu  Thr Leu Gln 
    1085                 1090                 1095             


Lys Gln  Ser Ala Phe Leu Gln  Glu His Asn Thr Thr  Leu Gln Thr 
    1100                 1105                 1110             


Gln Thr  Ala Lys Leu Gln Val  Glu Asn Ser Thr Leu  Ser Ser Gln 
    1115                 1120                 1125             


Ser Ala  Ala Leu Thr Ala Gln  Tyr Thr Leu Leu Gln  Asn His His 
    1130                 1135                 1140             


Thr Ala  Lys Glu Thr Glu Asn  Glu Ser Leu Gln Arg  Gln Gln Glu 
    1145                 1150                 1155             


Gln Leu  Thr Ala Ala Tyr Glu  Ala Leu Leu Gln Asp  His Glu His 
    1160                 1165                 1170             


Leu Gly  Thr Leu His Glu Arg  Gln Ser Ala Glu Tyr  Glu Ala Leu 
    1175                 1180                 1185             


Ile Arg  Gln His Ser Cys Leu  Lys Thr Leu His Arg  Asn Leu Glu 
    1190                 1195                 1200             


Leu Glu  His Lys Glu Leu Gly  Glu Arg His Gly Asp  Met Leu Lys 
    1205                 1210                 1215             


Arg Lys  Ala Glu Leu Glu Glu  Arg Glu Lys Val Leu  Thr Thr Glu 
    1220                 1225                 1230             


Arg Glu  Ala Leu Gln Gln Glu  Gln Arg Thr Asn Ala  Leu Ala Met 
    1235                 1240                 1245             


Gly Glu  Asn Gln Arg Leu Arg  Gly Glu Leu Asp Arg  Val Asn Phe 
    1250                 1255                 1260             


Leu His  His Gln Leu Lys Gly  Glu Tyr Glu Glu Leu  His Ala His 
    1265                 1270                 1275             


Thr Lys  Glu Leu Lys Thr Ser  Leu Asn Asn Ala Gln  Leu Glu Leu 
    1280                 1285                 1290             


Asn Arg  Trp Gln Ala Arg Phe  Asp Glu Leu Lys Glu  Gln His Gln 
    1295                 1300                 1305             


Thr Met  Asp Ile Ser Leu Thr  Lys Leu Asp Asn His  Cys Glu Leu 
    1310                 1315                 1320             


Leu Ser  Arg Leu Lys Gly Asn  Leu Glu Glu Glu Asn  His His Leu 
    1325                 1330                 1335             


Leu Ser  Gln Ile Gln Leu Leu  Ser Gln Gln Asn Gln  Met Leu Leu 
    1340                 1345                 1350             


Glu Gln  Asn Met Glu Asn Lys  Glu Gln Tyr His Glu  Glu Gln Lys 
    1355                 1360                 1365             


Gln Tyr  Ile Asp Lys Leu Asn  Ala Leu Arg Arg His  Lys Glu Lys 
    1370                 1375                 1380             


Leu Glu  Glu Lys Ile Met Asp  Gln Tyr Lys Phe Tyr  Asp Pro Pro 
    1385                 1390                 1395             


Pro Lys  Lys Lys Asn His Trp  Ile Gly Ala Lys Ala  Leu Val Lys 
    1400                 1405                 1410             


Leu Ile  Lys Pro Lys Lys Glu  Gly Ser Arg Glu Arg  Leu Lys Ser 
    1415                 1420                 1425             


Thr Val  Asp Ser Pro Pro Trp  Gln Leu Glu Ser Ser  Asp Pro Ala 
    1430                 1435                 1440             


Ser Pro  Ala Ala Ser Gln Pro  Leu Arg Ser Gln Ala  Glu Asn Pro 
    1445                 1450                 1455             


Asp Thr  Pro Ala Leu Gly Ser  Asn Cys Ala Glu Glu  Arg Asp Ala 
    1460                 1465                 1470             


His Asn  Gly Ser Val Gly Lys  Gly Pro Gly Asp Leu  Lys Pro Lys 
    1475                 1480                 1485             


Arg Gly  Ser Pro His Arg Gly  Ser Leu Asp Arg Thr  Asp Ala Ser 
    1490                 1495                 1500             


Thr Asp  Leu Ala Met Arg Ser  Trp Pro Ser Glu Leu  Gly Ser Arg 
    1505                 1510                 1515             


Thr Cys  Ser Thr Ser Ala Thr  Thr Thr Ala Pro Ser  Asn Ser Thr 
    1520                 1525                 1530             


Pro Ile  Ala Arg His Pro Gly  Arg Thr Lys Gly Tyr  Asn Ser Asp 
    1535                 1540                 1545             


Asp Asn  Leu Cys Glu Pro Ser  Leu Glu Phe Glu Val  Pro Asn His 
    1550                 1555                 1560             


Arg Gln  Tyr Val Ser Arg Pro  Ser Ser Leu Glu Ser  Ser Arg Asn 
    1565                 1570                 1575             


Thr Ser  Ser Asn Ser Ser Pro  Leu Asn Leu Lys Gly  Ser Ser Glu 
    1580                 1585                 1590             


Gln Leu  His Gly Arg Ser Glu  Ser Phe Ser Ser Glu  Asp Leu Ile 
    1595                 1600                 1605             


Pro Ser  Arg Asp Leu Ala Thr  Leu Pro Arg Glu Ala  Ser Thr Pro 
    1610                 1615                 1620             


Gly Arg  Asn Ala Leu Gly Arg  His Glu Tyr Pro Leu  Pro Arg Asn 
    1625                 1630                 1635             


Gly Pro  Leu Pro Gln Glu Gly  Ala Gln Lys Arg Gly  Thr Ala Pro 
    1640                 1645                 1650             


Pro Tyr  Val Gly Val Arg Pro  Cys Ser Ala Ser Pro  Ser Ser Glu 
    1655                 1660                 1665             


Met Val  Thr Leu Glu Glu Phe  Leu Glu Glu Ser Asn  Arg Ser Ser 
    1670                 1675                 1680             


Pro Thr  His Asp Thr Pro Ser  Cys Arg Asp Asp Leu  Leu Ser Asp 
    1685                 1690                 1695             


Tyr Phe  Arg Lys Ala Ser Asp  Pro Pro Ala Ile Gly  Gly Gln Pro 
    1700                 1705                 1710             


Gly Pro  Pro Ala Lys Lys Glu  Gly Ala Lys Met Pro  Thr Asn Phe 
    1715                 1720                 1725             


Val Ala  Pro Thr Val Lys Met  Ala Ala Pro Thr Ser  Glu Gly Arg 
    1730                 1735                 1740             


Pro Leu  Lys Pro Gly Gln Tyr  Val Lys Pro Asn Phe  Arg Leu Thr 
    1745                 1750                 1755             


Glu Ala  Glu Ala Pro Pro Ser  Val Ala Pro Arg Gln  Ala Gln Pro 
    1760                 1765                 1770             


Pro Gln  Ser Leu Ser Leu Gly  Arg Pro Arg Gln Ala  Pro Val Pro 
    1775                 1780                 1785             


Pro Ala  Ser His Ala Pro Ala  Ser Arg Ser Ala Ser  Leu Ser Arg 
    1790                 1795                 1800             


Ala Phe  Ser Leu Ala Ser Ala  Asp Leu Leu Arg Ala  Ser Gly Pro 
    1805                 1810                 1815             


Glu Ala  Cys Lys Gln Glu Ser  Pro Gln Lys Leu Gly  Ala Pro Glu 
    1820                 1825                 1830             


Ala Leu  Gly Gly Arg Glu Thr  Gly Ser His Thr Leu  Gln Ser Pro 
    1835                 1840                 1845             


Ala Pro  Pro Ser Ser His Ser  Leu Ala Arg Glu Arg  Thr Pro Leu 
    1850                 1855                 1860             


Val Gly  Lys Ala Gly Ser Ser  Cys Gln Gly Pro Gly  Pro Arg Ser 
    1865                 1870                 1875             


Arg Pro  Leu Asp Thr Arg Arg  Phe Ser Leu Ala Pro  Pro Lys Glu 
    1880                 1885                 1890             


Glu Arg  Leu Ala Pro Leu His  Gln Ser Ala Thr Ala  Pro Ala Ile 
    1895                 1900                 1905             


Ala Thr  Ala Gly Ala Gly Ala  Ala Ala Ala Gly Ser  Gly Ser Asn 
    1910                 1915                 1920             


Ser Gln  Leu Leu His Phe Ser  Pro Ala Ala Ala Pro  Ala Ala Arg 
    1925                 1930                 1935             


Thr Lys  Pro Lys Ala Pro Pro  Arg Ser Gly Glu Val  Ala Thr Ile 
    1940                 1945                 1950             


Thr Pro  Val Arg Ala Gly Leu  Ser Leu Ser Glu Gly  Asp Gly Val 
    1955                 1960                 1965             


Pro Gly  Gln Gly Cys Ser Glu  Gly Leu Pro Ala Lys  Ser Pro Gly 
    1970                 1975                 1980             


Arg Ser  Pro Asp Leu Ala Pro  His Pro Gly Arg Ala  Leu Glu Asp 
    1985                 1990                 1995             


Cys Ser  Arg Gly Ser Val Ser  Lys Ser Ser Pro Ala  Ser Pro Glu 
    2000                 2005                 2010             


Pro Gly  Gly Asp Pro Gln Thr  Val Trp Tyr Glu Tyr  Gly Cys Val 
    2015                 2020                 2025             


<210>  213
<211>  801
<212>  PRT
<213>  Homo sapiens

<400>  213

Met Glu Ser Arg Ala Glu Gly Gly Ser Pro Ala Val Phe Asp Trp Phe 
1               5                   10                  15      


Phe Glu Ala Ala Cys Pro Ala Ser Leu Gln Glu Asp Pro Pro Ile Leu 
            20                  25                  30          


Arg Gln Phe Pro Pro Asp Phe Arg Asp Gln Glu Ala Met Gln Met Val 
        35                  40                  45              


Pro Lys Phe Cys Phe Pro Phe Asp Val Glu Arg Glu Pro Pro Ser Pro 
    50                  55                  60                  


Ala Val Gln His Phe Thr Phe Ala Leu Thr Asp Leu Ala Gly Asn Arg 
65                  70                  75                  80  


Arg Phe Gly Phe Cys Arg Leu Arg Ala Gly Thr Gln Ser Cys Leu Cys 
                85                  90                  95      


Ile Leu Ser His Leu Pro Trp Phe Glu Val Phe Tyr Lys Leu Leu Asn 
            100                 105                 110         


Thr Val Gly Asp Leu Leu Ala Gln Asp Gln Val Thr Glu Ala Glu Glu 
        115                 120                 125             


Leu Leu Gln Asn Leu Phe Gln Gln Ser Leu Ser Gly Pro Gln Ala Ser 
    130                 135                 140                 


Val Gly Leu Glu Leu Gly Ser Gly Val Thr Val Ser Ser Gly Gln Gly 
145                 150                 155                 160 


Ile Pro Pro Pro Thr Arg Gly Asn Ser Lys Pro Leu Ser Cys Phe Val 
                165                 170                 175     


Ala Pro Asp Ser Gly Arg Leu Pro Ser Ile Pro Glu Asn Arg Asn Leu 
            180                 185                 190         


Thr Glu Leu Val Val Ala Val Thr Asp Glu Asn Ile Val Gly Leu Phe 
        195                 200                 205             


Ala Ala Leu Leu Ala Glu Arg Arg Val Leu Leu Thr Ala Ser Lys Leu 
    210                 215                 220                 


Ser Thr Leu Thr Ser Cys Val His Ala Ser Cys Ala Leu Leu Tyr Pro 
225                 230                 235                 240 


Met Arg Trp Glu His Val Leu Ile Pro Thr Leu Pro Pro His Leu Leu 
                245                 250                 255     


Asp Tyr Cys Cys Ala Pro Met Pro Tyr Leu Ile Gly Val His Ala Ser 
            260                 265                 270         


Leu Ala Glu Arg Val Arg Glu Lys Ala Leu Glu Asp Val Val Val Leu 
        275                 280                 285             


Asn Val Asp Ala Asn Thr Leu Glu Thr Thr Phe Asn Asp Val Gln Ala 
    290                 295                 300                 


Leu Pro Pro Asp Val Val Ser Leu Leu Arg Leu Arg Leu Arg Lys Val 
305                 310                 315                 320 


Ala Leu Ala Pro Gly Glu Gly Val Ser Arg Leu Phe Leu Lys Ala Gln 
                325                 330                 335     


Ala Leu Leu Phe Gly Gly Tyr Arg Asp Ala Leu Val Cys Ser Pro Gly 
            340                 345                 350         


Gln Pro Val Thr Phe Ser Glu Glu Val Phe Leu Ala Gln Lys Pro Gly 
        355                 360                 365             


Ala Pro Leu Gln Ala Phe His Arg Arg Ala Val His Leu Gln Leu Phe 
    370                 375                 380                 


Lys Gln Phe Ile Glu Ala Arg Leu Glu Lys Leu Asn Lys Gly Glu Gly 
385                 390                 395                 400 


Phe Ser Asp Gln Phe Glu Gln Glu Ile Thr Gly Cys Gly Ala Ser Ser 
                405                 410                 415     


Gly Ala Leu Arg Ser Tyr Gln Leu Trp Ala Asp Asn Leu Lys Lys Gly 
            420                 425                 430         


Gly Gly Ala Leu Leu His Ser Val Lys Ala Lys Thr Gln Pro Ala Val 
        435                 440                 445             


Lys Asn Met Tyr Arg Ser Ala Lys Ser Gly Leu Lys Gly Val Gln Ser 
    450                 455                 460                 


Leu Leu Met Tyr Lys Asp Gly Asp Ser Val Leu Gln Arg Gly Gly Ser 
465                 470                 475                 480 


Leu Arg Ala Pro Ala Leu Pro Ser Arg Ser Asp Arg Leu Gln Gln Arg 
                485                 490                 495     


Leu Pro Ile Thr Gln His Phe Gly Lys Asn Arg Pro Leu Arg Pro Ser 
            500                 505                 510         


Arg Arg Arg Gln Leu Glu Glu Gly Thr Ser Glu Pro Pro Gly Ala Gly 
        515                 520                 525             


Thr Pro Pro Leu Ser Pro Glu Asp Glu Gly Cys Pro Trp Ala Glu Glu 
    530                 535                 540                 


Ala Leu Asp Ser Ser Phe Leu Gly Ser Gly Glu Glu Leu Asp Leu Leu 
545                 550                 555                 560 


Ser Glu Ile Leu Asp Ser Leu Ser Met Gly Ala Lys Ser Ala Gly Ser 
                565                 570                 575     


Leu Arg Pro Ser Gln Ser Leu Asp Cys Cys His Arg Gly Asp Leu Asp 
            580                 585                 590         


Ser Cys Phe Ser Leu Pro Asn Ile Pro Arg Trp Gln Pro Asp Asp Lys 
        595                 600                 605             


Lys Leu Pro Glu Pro Glu Pro Gln Pro Leu Ser Leu Pro Ser Leu Gln 
    610                 615                 620                 


Asn Ala Ser Ser Leu Asp Ala Thr Ser Ser Ser Lys Asp Ser Arg Ser 
625                 630                 635                 640 


Gln Leu Ile Pro Ser Glu Ser Asp Gln Glu Val Thr Ser Pro Ser Gln 
                645                 650                 655     


Ser Ser Thr Ala Ser Ala Asp Pro Ser Ile Trp Gly Asp Pro Lys Pro 
            660                 665                 670         


Ser Pro Leu Thr Glu Pro Leu Ile Leu His Leu Thr Pro Ser His Lys 
        675                 680                 685             


Ala Ala Glu Asp Ser Thr Ala Gln Glu Asn Pro Thr Pro Trp Leu Ser 
    690                 695                 700                 


Thr Ala Pro Thr Glu Pro Ser Pro Pro Glu Ser Pro Gln Ile Leu Ala 
705                 710                 715                 720 


Pro Thr Lys Pro Asn Phe Asp Ile Ala Trp Thr Ser Gln Pro Leu Asp 
                725                 730                 735     


Pro Ser Ser Asp Pro Ser Ser Leu Glu Asp Pro Arg Ala Arg Pro Pro 
            740                 745                 750         


Lys Ala Leu Leu Ala Glu Arg Ala His Leu Gln Pro Arg Glu Glu Pro 
        755                 760                 765             


Gly Ala Leu Asn Ser Pro Ala Thr Pro Thr Ser Asn Cys Gln Lys Ser 
    770                 775                 780                 


Gln Pro Ser Ser Arg Pro Arg Val Ala Asp Leu Lys Lys Cys Phe Glu 
785                 790                 795                 800 


Gly 
    


<210>  214
<211>  613
<212>  PRT
<213>  Homo sapiens

<400>  214

Met Ala Ala Thr Ala Val Ala Ala Ala Val Ala Gly Thr Glu Ser Ala 
1               5                   10                  15      


Gln Gly Pro Pro Gly Pro Ala Ala Ser Leu Glu Leu Trp Leu Asn Lys 
            20                  25                  30          


Ala Thr Asp Pro Ser Met Ser Glu Gln Asp Trp Ser Ala Ile Gln Asn 
        35                  40                  45              


Phe Cys Glu Gln Val Asn Thr Asp Pro Asn Gly Pro Thr His Ala Pro 
    50                  55                  60                  


Trp Leu Leu Ala His Lys Ile Gln Ser Pro Gln Glu Lys Glu Ala Leu 
65                  70                  75                  80  


Tyr Ala Leu Thr Val Leu Glu Met Cys Met Asn His Cys Gly Glu Lys 
                85                  90                  95      


Phe His Ser Glu Val Ala Lys Phe Arg Phe Leu Asn Glu Leu Ile Lys 
            100                 105                 110         


Val Leu Ser Pro Lys Tyr Leu Gly Ser Trp Ala Thr Gly Lys Val Lys 
        115                 120                 125             


Gly Arg Val Ile Glu Ile Leu Phe Ser Trp Thr Val Trp Phe Pro Glu 
    130                 135                 140                 


Asp Ile Lys Ile Arg Asp Ala Tyr Gln Met Leu Lys Lys Gln Gly Ile 
145                 150                 155                 160 


Ile Lys Gln Asp Pro Lys Leu Pro Val Asp Lys Ile Leu Pro Pro Pro 
                165                 170                 175     


Ser Pro Trp Pro Lys Ser Ser Ile Phe Asp Ala Asp Glu Glu Lys Ser 
            180                 185                 190         


Lys Leu Leu Thr Arg Leu Leu Lys Ser Asn His Pro Glu Asp Leu Gln 
        195                 200                 205             


Ala Ala Asn Arg Leu Ile Lys Asn Leu Val Lys Glu Glu Gln Glu Lys 
    210                 215                 220                 


Ser Glu Lys Val Ser Lys Arg Val Ser Ala Val Glu Glu Val Arg Ser 
225                 230                 235                 240 


His Val Lys Val Leu Gln Glu Met Leu Ser Met Tyr Arg Arg Pro Gly 
                245                 250                 255     


Gln Ala Pro Pro Asp Gln Glu Ala Leu Gln Val Val Tyr Glu Arg Cys 
            260                 265                 270         


Glu Lys Leu Arg Pro Thr Leu Phe Arg Leu Ala Ser Asp Thr Thr Asp 
        275                 280                 285             


Asp Asp Asp Ala Leu Ala Glu Ile Leu Gln Ala Asn Asp Leu Leu Thr 
    290                 295                 300                 


Gln Gly Val Leu Leu Tyr Lys Gln Val Met Glu Gly Arg Val Thr Phe 
305                 310                 315                 320 


Gly Asn Arg Val Thr Ser Ser Leu Gly Asp Ile Pro Val Ser Arg Val 
                325                 330                 335     


Phe Gln Asn Pro Ala Gly Cys Met Lys Thr Cys Pro Leu Ile Asp Leu 
            340                 345                 350         


Glu Val Asp Asn Gly Pro Ala Gln Met Gly Thr Val Val Pro Ser Leu 
        355                 360                 365             


Leu His Gln Asp Leu Ala Ala Leu Gly Ile Ser Asp Ala Pro Val Thr 
    370                 375                 380                 


Gly Met Val Ser Gly Gln Asn Cys Cys Glu Glu Lys Arg Asn Pro Ser 
385                 390                 395                 400 


Ser Ser Thr Leu Pro Gly Gly Gly Val Gln Asn Pro Ser Ala Asp Arg 
                405                 410                 415     


Asn Leu Leu Asp Leu Leu Ser Ala Gln Pro Ala Pro Cys Pro Leu Asn 
            420                 425                 430         


Tyr Val Ser Gln Lys Ser Val Pro Lys Glu Val Pro Pro Gly Thr Lys 
        435                 440                 445             


Ser Ser Pro Gly Trp Ser Trp Glu Ala Gly Pro Leu Ala Pro Ser Pro 
    450                 455                 460                 


Ser Ser Gln Asn Thr Pro Leu Ala Gln Val Phe Val Pro Leu Glu Ser 
465                 470                 475                 480 


Val Lys Pro Ser Ser Leu Pro Pro Leu Ile Val Tyr Asp Arg Asn Gly 
                485                 490                 495     


Phe Arg Ile Leu Leu His Phe Ser Gln Thr Gly Ala Pro Gly His Pro 
            500                 505                 510         


Glu Val Gln Val Leu Leu Leu Thr Met Met Ser Thr Ala Pro Gln Pro 
        515                 520                 525             


Val Trp Asp Ile Met Phe Gln Val Ala Val Pro Lys Ser Met Arg Val 
    530                 535                 540                 


Lys Leu Gln Pro Ala Ser Ser Ser Lys Leu Pro Ala Phe Ser Pro Leu 
545                 550                 555                 560 


Met Pro Pro Ala Val Ile Ser Gln Met Leu Leu Leu Asp Asn Pro His 
                565                 570                 575     


Lys Glu Pro Ile Arg Leu Arg Tyr Lys Leu Thr Phe Asn Gln Gly Gly 
            580                 585                 590         


Gln Pro Phe Ser Glu Val Gly Glu Val Lys Asp Phe Pro Asp Leu Ala 
        595                 600                 605             


Val Leu Gly Ala Ala 
    610             


<210>  215
<211>  564
<212>  PRT
<213>  Homo sapiens

<400>  215

Met Ala Val Phe Arg Ser Gly Leu Leu Val Leu Thr Thr Pro Leu Ala 
1               5                   10                  15      


Ser Leu Ala Pro Arg Leu Ala Ser Ile Leu Thr Ser Ala Ala Arg Leu 
            20                  25                  30          


Val Asn His Thr Leu Tyr Val His Leu Gln Pro Gly Met Ser Leu Glu 
        35                  40                  45              


Gly Pro Ala Gln Pro Gln Ser Ser Pro Val Gln Ala Thr Phe Glu Val 
    50                  55                  60                  


Leu Asp Phe Ile Thr His Leu Tyr Ala Gly Ala Asp Val His Arg His 
65                  70                  75                  80  


Leu Asp Val Arg Ile Leu Leu Thr Asn Ile Arg Thr Lys Ser Thr Phe 
                85                  90                  95      


Leu Pro Pro Leu Pro Thr Ser Val Gln Asn Leu Ala His Pro Pro Glu 
            100                 105                 110         


Val Val Leu Thr Asp Phe Gln Thr Leu Asp Gly Ser Gln Tyr Asn Pro 
        115                 120                 125             


Val Lys Gln Gln Leu Val Arg Tyr Ala Thr Ser Cys Tyr Ser Cys Cys 
    130                 135                 140                 


Pro Arg Leu Ala Ser Val Leu Leu Tyr Ser Asp Tyr Gly Ile Gly Glu 
145                 150                 155                 160 


Val Pro Val Glu Pro Leu Asp Val Pro Leu Pro Ser Thr Ile Arg Pro 
                165                 170                 175     


Ala Ser Pro Val Ala Gly Ser Pro Lys Gln Pro Val Arg Gly Tyr Tyr 
            180                 185                 190         


Arg Gly Ala Val Gly Gly Thr Phe Asp Arg Leu His Asn Ala His Lys 
        195                 200                 205             


Val Leu Leu Ser Val Ala Cys Ile Leu Ala Gln Glu Gln Leu Val Val 
    210                 215                 220                 


Gly Val Ala Asp Lys Asp Leu Leu Lys Ser Lys Leu Leu Pro Glu Leu 
225                 230                 235                 240 


Leu Gln Pro Tyr Thr Glu Arg Val Glu His Leu Ser Glu Phe Leu Val 
                245                 250                 255     


Asp Ile Lys Pro Ser Leu Thr Phe Asp Val Ile Pro Leu Leu Asp Pro 
            260                 265                 270         


Tyr Gly Pro Ala Gly Ser Asp Pro Ser Leu Glu Phe Leu Val Val Ser 
        275                 280                 285             


Glu Glu Thr Tyr Arg Gly Gly Met Ala Ile Asn Arg Phe Arg Leu Glu 
    290                 295                 300                 


Asn Asp Leu Glu Glu Leu Ala Leu Tyr Gln Ile Gln Leu Leu Lys Asp 
305                 310                 315                 320 


Leu Arg His Thr Glu Asn Glu Glu Asp Lys Val Ser Ser Ser Ser Phe 
                325                 330                 335     


Arg Gln Arg Met Leu Gly Asn Leu Leu Arg Pro Pro Tyr Glu Arg Pro 
            340                 345                 350         


Glu Leu Pro Thr Cys Leu Tyr Val Ile Gly Leu Thr Gly Ile Ser Gly 
        355                 360                 365             


Ser Gly Lys Ser Ser Ile Ala Gln Arg Leu Lys Gly Leu Gly Ala Phe 
    370                 375                 380                 


Val Ile Asp Ser Asp His Leu Gly His Arg Ala Tyr Ala Pro Gly Gly 
385                 390                 395                 400 


Pro Ala Tyr Gln Pro Val Val Glu Ala Phe Gly Thr Asp Ile Leu His 
                405                 410                 415     


Lys Asp Gly Ile Ile Asn Arg Lys Val Leu Gly Ser Arg Val Phe Gly 
            420                 425                 430         


Asn Lys Lys Gln Leu Lys Ile Leu Thr Asp Ile Met Trp Pro Ile Ile 
        435                 440                 445             


Ala Lys Leu Ala Arg Glu Glu Met Asp Arg Ala Val Ala Glu Gly Lys 
    450                 455                 460                 


Arg Val Cys Val Ile Asp Ala Ala Val Leu Leu Glu Ala Gly Trp Gln 
465                 470                 475                 480 


Asn Leu Val His Glu Val Trp Thr Ala Val Ile Pro Glu Thr Glu Ala 
                485                 490                 495     


Val Arg Arg Ile Val Glu Arg Asp Gly Leu Ser Glu Ala Ala Ala Gln 
            500                 505                 510         


Ser Arg Leu Gln Ser Gln Met Ser Gly Gln Gln Leu Val Glu Gln Ser 
        515                 520                 525             


His Val Val Leu Ser Thr Leu Trp Glu Pro His Ile Thr Gln Arg Gln 
    530                 535                 540                 


Val Glu Lys Ala Trp Ala Leu Leu Gln Lys Arg Ile Pro Lys Thr His 
545                 550                 555                 560 


Gln Ala Leu Asp 
                


<210>  216
<211>  317
<212>  PRT
<213>  Homo sapiens

<400>  216

Met Gly Tyr Asp Val Thr Arg Phe Gln Gly Asp Val Asp Glu Asp Leu 
1               5                   10                  15      


Ile Cys Pro Ile Cys Ser Gly Val Leu Glu Glu Pro Val Gln Ala Pro 
            20                  25                  30          


His Cys Glu His Ala Phe Cys Asn Ala Cys Ile Thr Gln Trp Phe Ser 
        35                  40                  45              


Gln Gln Gln Thr Cys Pro Val Asp Arg Ser Val Val Thr Val Ala His 
    50                  55                  60                  


Leu Arg Pro Val Pro Arg Ile Met Arg Asn Met Leu Ser Lys Leu Gln 
65                  70                  75                  80  


Ile Ala Cys Asp Asn Ala Val Phe Gly Cys Ser Ala Val Val Arg Leu 
                85                  90                  95      


Asp Asn Leu Met Ser His Leu Ser Asp Cys Glu His Asn Pro Lys Arg 
            100                 105                 110         


Pro Val Thr Cys Glu Gln Gly Cys Gly Leu Glu Met Pro Lys Asp Glu 
        115                 120                 125             


Leu Pro Asn His Asn Cys Ile Lys His Leu Arg Ser Val Val Gln Gln 
    130                 135                 140                 


Gln Gln Thr Arg Ile Ala Glu Leu Glu Lys Thr Ser Ala Glu His Lys 
145                 150                 155                 160 


His Gln Leu Ala Glu Gln Lys Arg Asp Ile Gln Leu Leu Lys Ala Tyr 
                165                 170                 175     


Met Arg Ala Ile Arg Ser Val Asn Pro Asn Leu Gln Asn Leu Glu Glu 
            180                 185                 190         


Thr Ile Glu Tyr Asn Glu Ile Leu Glu Trp Val Asn Ser Leu Gln Pro 
        195                 200                 205             


Ala Arg Val Thr Arg Trp Gly Gly Met Ile Ser Thr Pro Asp Ala Val 
    210                 215                 220                 


Leu Gln Ala Val Ile Lys Arg Ser Leu Val Glu Ser Gly Cys Pro Ala 
225                 230                 235                 240 


Ser Ile Val Asn Glu Leu Ile Glu Asn Ala His Glu Arg Ser Trp Pro 
                245                 250                 255     


Gln Gly Leu Ala Thr Leu Glu Thr Arg Gln Met Asn Arg Arg Tyr Tyr 
            260                 265                 270         


Glu Asn Tyr Val Ala Lys Arg Ile Pro Gly Lys Gln Ala Val Val Val 
        275                 280                 285             


Met Ala Cys Glu Asn Gln His Met Gly Asp Asp Met Val Gln Glu Pro 
    290                 295                 300                 


Gly Leu Val Met Ile Phe Ala His Gly Val Glu Glu Ile 
305                 310                 315         


<210>  217
<211>  83
<212>  PRT
<213>  Homo sapiens

<400>  217

Met Ser Phe Phe Gln Leu Leu Met Lys Arg Lys Glu Leu Ile Pro Leu 
1               5                   10                  15      


Val Val Phe Met Thr Val Ala Ala Gly Gly Ala Ser Ser Phe Ala Val 
            20                  25                  30          


Tyr Ser Leu Trp Lys Thr Asp Val Ile Leu Asp Arg Lys Lys Asn Pro 
        35                  40                  45              


Glu Pro Trp Glu Thr Val Asp Pro Thr Val Pro Gln Lys Leu Ile Thr 
    50                  55                  60                  


Ile Asn Gln Gln Trp Lys Pro Ile Glu Glu Leu Gln Asn Val Gln Arg 
65                  70                  75                  80  


Val Thr Lys 
            


<210>  218
<211>  1210
<212>  PRT
<213>  Homo sapiens

<400>  218

Met Arg Pro Ser Gly Thr Ala Gly Ala Ala Leu Leu Ala Leu Leu Ala 
1               5                   10                  15      


Ala Leu Cys Pro Ala Ser Arg Ala Leu Glu Glu Lys Lys Val Cys Gln 
            20                  25                  30          


Gly Thr Ser Asn Lys Leu Thr Gln Leu Gly Thr Phe Glu Asp His Phe 
        35                  40                  45              


Leu Ser Leu Gln Arg Met Phe Asn Asn Cys Glu Val Val Leu Gly Asn 
    50                  55                  60                  


Leu Glu Ile Thr Tyr Val Gln Arg Asn Tyr Asp Leu Ser Phe Leu Lys 
65                  70                  75                  80  


Thr Ile Gln Glu Val Ala Gly Tyr Val Leu Ile Ala Leu Asn Thr Val 
                85                  90                  95      


Glu Arg Ile Pro Leu Glu Asn Leu Gln Ile Ile Arg Gly Asn Met Tyr 
            100                 105                 110         


Tyr Glu Asn Ser Tyr Ala Leu Ala Val Leu Ser Asn Tyr Asp Ala Asn 
        115                 120                 125             


Lys Thr Gly Leu Lys Glu Leu Pro Met Arg Asn Leu Gln Glu Ile Leu 
    130                 135                 140                 


His Gly Ala Val Arg Phe Ser Asn Asn Pro Ala Leu Cys Asn Val Glu 
145                 150                 155                 160 


Ser Ile Gln Trp Arg Asp Ile Val Ser Ser Asp Phe Leu Ser Asn Met 
                165                 170                 175     


Ser Met Asp Phe Gln Asn His Leu Gly Ser Cys Gln Lys Cys Asp Pro 
            180                 185                 190         


Ser Cys Pro Asn Gly Ser Cys Trp Gly Ala Gly Glu Glu Asn Cys Gln 
        195                 200                 205             


Lys Leu Thr Lys Ile Ile Cys Ala Gln Gln Cys Ser Gly Arg Cys Arg 
    210                 215                 220                 


Gly Lys Ser Pro Ser Asp Cys Cys His Asn Gln Cys Ala Ala Gly Cys 
225                 230                 235                 240 


Thr Gly Pro Arg Glu Ser Asp Cys Leu Val Cys Arg Lys Phe Arg Asp 
                245                 250                 255     


Glu Ala Thr Cys Lys Asp Thr Cys Pro Pro Leu Met Leu Tyr Asn Pro 
            260                 265                 270         


Thr Thr Tyr Gln Met Asp Val Asn Pro Glu Gly Lys Tyr Ser Phe Gly 
        275                 280                 285             


Ala Thr Cys Val Lys Lys Cys Pro Arg Asn Tyr Val Val Thr Asp His 
    290                 295                 300                 


Gly Ser Cys Val Arg Ala Cys Gly Ala Asp Ser Tyr Glu Met Glu Glu 
305                 310                 315                 320 


Asp Gly Val Arg Lys Cys Lys Lys Cys Glu Gly Pro Cys Arg Lys Val 
                325                 330                 335     


Cys Asn Gly Ile Gly Ile Gly Glu Phe Lys Asp Ser Leu Ser Ile Asn 
            340                 345                 350         


Ala Thr Asn Ile Lys His Phe Lys Asn Cys Thr Ser Ile Ser Gly Asp 
        355                 360                 365             


Leu His Ile Leu Pro Val Ala Phe Arg Gly Asp Ser Phe Thr His Thr 
    370                 375                 380                 


Pro Pro Leu Asp Pro Gln Glu Leu Asp Ile Leu Lys Thr Val Lys Glu 
385                 390                 395                 400 


Ile Thr Gly Phe Leu Leu Ile Gln Ala Trp Pro Glu Asn Arg Thr Asp 
                405                 410                 415     


Leu His Ala Phe Glu Asn Leu Glu Ile Ile Arg Gly Arg Thr Lys Gln 
            420                 425                 430         


His Gly Gln Phe Ser Leu Ala Val Val Ser Leu Asn Ile Thr Ser Leu 
        435                 440                 445             


Gly Leu Arg Ser Leu Lys Glu Ile Ser Asp Gly Asp Val Ile Ile Ser 
    450                 455                 460                 


Gly Asn Lys Asn Leu Cys Tyr Ala Asn Thr Ile Asn Trp Lys Lys Leu 
465                 470                 475                 480 


Phe Gly Thr Ser Gly Gln Lys Thr Lys Ile Ile Ser Asn Arg Gly Glu 
                485                 490                 495     


Asn Ser Cys Lys Ala Thr Gly Gln Val Cys His Ala Leu Cys Ser Pro 
            500                 505                 510         


Glu Gly Cys Trp Gly Pro Glu Pro Arg Asp Cys Val Ser Cys Arg Asn 
        515                 520                 525             


Val Ser Arg Gly Arg Glu Cys Val Asp Lys Cys Asn Leu Leu Glu Gly 
    530                 535                 540                 


Glu Pro Arg Glu Phe Val Glu Asn Ser Glu Cys Ile Gln Cys His Pro 
545                 550                 555                 560 


Glu Cys Leu Pro Gln Ala Met Asn Ile Thr Cys Thr Gly Arg Gly Pro 
                565                 570                 575     


Asp Asn Cys Ile Gln Cys Ala His Tyr Ile Asp Gly Pro His Cys Val 
            580                 585                 590         


Lys Thr Cys Pro Ala Gly Val Met Gly Glu Asn Asn Thr Leu Val Trp 
        595                 600                 605             


Lys Tyr Ala Asp Ala Gly His Val Cys His Leu Cys His Pro Asn Cys 
    610                 615                 620                 


Thr Tyr Gly Cys Thr Gly Pro Gly Leu Glu Gly Cys Pro Thr Asn Gly 
625                 630                 635                 640 


Pro Lys Ile Pro Ser Ile Ala Thr Gly Met Val Gly Ala Leu Leu Leu 
                645                 650                 655     


Leu Leu Val Val Ala Leu Gly Ile Gly Leu Phe Met Arg Arg Arg His 
            660                 665                 670         


Ile Val Arg Lys Arg Thr Leu Arg Arg Leu Leu Gln Glu Arg Glu Leu 
        675                 680                 685             


Val Glu Pro Leu Thr Pro Ser Gly Glu Ala Pro Asn Gln Ala Leu Leu 
    690                 695                 700                 


Arg Ile Leu Lys Glu Thr Glu Phe Lys Lys Ile Lys Val Leu Gly Ser 
705                 710                 715                 720 


Gly Ala Phe Gly Thr Val Tyr Lys Gly Leu Trp Ile Pro Glu Gly Glu 
                725                 730                 735     


Lys Val Lys Ile Pro Val Ala Ile Lys Glu Leu Arg Glu Ala Thr Ser 
            740                 745                 750         


Pro Lys Ala Asn Lys Glu Ile Leu Asp Glu Ala Tyr Val Met Ala Ser 
        755                 760                 765             


Val Asp Asn Pro His Val Cys Arg Leu Leu Gly Ile Cys Leu Thr Ser 
    770                 775                 780                 


Thr Val Gln Leu Ile Thr Gln Leu Met Pro Phe Gly Cys Leu Leu Asp 
785                 790                 795                 800 


Tyr Val Arg Glu His Lys Asp Asn Ile Gly Ser Gln Tyr Leu Leu Asn 
                805                 810                 815     


Trp Cys Val Gln Ile Ala Lys Gly Met Asn Tyr Leu Glu Asp Arg Arg 
            820                 825                 830         


Leu Val His Arg Asp Leu Ala Ala Arg Asn Val Leu Val Lys Thr Pro 
        835                 840                 845             


Gln His Val Lys Ile Thr Asp Phe Gly Leu Ala Lys Gln Leu Gly Ala 
    850                 855                 860                 


Glu Glu Lys Glu Tyr His Ala Glu Gly Gly Lys Val Pro Ile Lys Trp 
865                 870                 875                 880 


Met Ala Leu Glu Ser Ile Leu His Arg Ile Tyr Thr His Gln Ser Asp 
                885                 890                 895     


Val Trp Ser Tyr Gly Val Thr Val Trp Glu Leu Met Thr Phe Gly Ser 
            900                 905                 910         


Lys Pro Tyr Asp Gly Ile Pro Ala Ser Glu Ile Ser Ser Ile Leu Glu 
        915                 920                 925             


Lys Gly Glu Arg Leu Pro Gln Pro Pro Ile Cys Thr Ile Asp Val Tyr 
    930                 935                 940                 


Met Ile Met Val Lys Cys Trp Met Ile Asp Ala Asp Ser Arg Pro Lys 
945                 950                 955                 960 


Phe Arg Glu Leu Ile Ile Glu Phe Ser Lys Met Ala Arg Asp Pro Gln 
                965                 970                 975     


Arg Tyr Leu Val Ile Gln Gly Asp Glu Arg Met His Leu Pro Ser Pro 
            980                 985                 990         


Thr Asp Ser Asn Phe Tyr Arg Ala  Leu Met Asp Glu Glu  Asp Met Asp 
        995                 1000                 1005             


Asp Val  Val Asp Ala Asp Glu  Tyr Leu Ile Pro Gln  Gln Gly Phe 
    1010                 1015                 1020             


Phe Ser  Ser Pro Ser Thr Ser  Arg Thr Pro Leu Leu  Ser Ser Leu 
    1025                 1030                 1035             


Ser Ala  Thr Ser Asn Asn Ser  Thr Val Ala Cys Ile  Asp Arg Asn 
    1040                 1045                 1050             


Gly Leu  Gln Ser Cys Pro Ile  Lys Glu Asp Ser Phe  Leu Gln Arg 
    1055                 1060                 1065             


Tyr Ser  Ser Asp Pro Thr Gly  Ala Leu Thr Glu Asp  Ser Ile Asp 
    1070                 1075                 1080             


Asp Thr  Phe Leu Pro Val Pro  Glu Tyr Ile Asn Gln  Ser Val Pro 
    1085                 1090                 1095             


Lys Arg  Pro Ala Gly Ser Val  Gln Asn Pro Val Tyr  His Asn Gln 
    1100                 1105                 1110             


Pro Leu  Asn Pro Ala Pro Ser  Arg Asp Pro His Tyr  Gln Asp Pro 
    1115                 1120                 1125             


His Ser  Thr Ala Val Gly Asn  Pro Glu Tyr Leu Asn  Thr Val Gln 
    1130                 1135                 1140             


Pro Thr  Cys Val Asn Ser Thr  Phe Asp Ser Pro Ala  His Trp Ala 
    1145                 1150                 1155             


Gln Lys  Gly Ser His Gln Ile  Ser Leu Asp Asn Pro  Asp Tyr Gln 
    1160                 1165                 1170             


Gln Asp  Phe Phe Pro Lys Glu  Ala Lys Pro Asn Gly  Ile Phe Lys 
    1175                 1180                 1185             


Gly Ser  Thr Ala Glu Asn Ala  Glu Tyr Leu Arg Val  Ala Pro Gln 
    1190                 1195                 1200             


Ser Ser  Glu Phe Ile Gly Ala  
    1205                 1210 


<210>  219
<211>  359
<212>  PRT
<213>  Homo sapiens

<400>  219

Met Ile Ala Ala Gln Ala Lys Leu Val Tyr Gln Leu Asn Lys Tyr Tyr 
1               5                   10                  15      


Thr Glu Arg Cys Gln Ala Arg Lys Ala Ala Ile Ala Lys Thr Ile Arg 
            20                  25                  30          


Glu Val Cys Lys Val Val Ser Asp Val Leu Lys Glu Val Glu Val Gln 
        35                  40                  45              


Glu Pro Arg Phe Ile Ser Ser Leu Ser Glu Ile Asp Ala Arg Tyr Glu 
    50                  55                  60                  


Gly Leu Glu Val Ile Ser Pro Thr Glu Phe Glu Val Val Leu Tyr Leu 
65                  70                  75                  80  


Asn Gln Met Gly Val Phe Asn Phe Val Asp Asp Gly Ser Leu Pro Gly 
                85                  90                  95      


Cys Ala Val Leu Lys Leu Ser Asp Gly Arg Lys Arg Ser Met Ser Leu 
            100                 105                 110         


Trp Val Glu Phe Ile Thr Ala Ser Gly Tyr Leu Ser Ala Arg Lys Ile 
        115                 120                 125             


Arg Ser Arg Phe Gln Thr Leu Val Ala Gln Ala Val Asp Lys Cys Ser 
    130                 135                 140                 


Tyr Arg Asp Val Val Lys Met Ile Ala Asp Thr Ser Glu Val Lys Leu 
145                 150                 155                 160 


Arg Ile Arg Glu Arg Tyr Val Val Gln Ile Thr Pro Ala Phe Lys Cys 
                165                 170                 175     


Thr Gly Ile Trp Pro Arg Ser Ala Ala Gln Trp Pro Met Pro His Ile 
            180                 185                 190         


Pro Trp Pro Gly Pro Asn Arg Val Ala Glu Val Lys Ala Glu Gly Phe 
        195                 200                 205             


Asn Leu Leu Ser Lys Glu Cys Tyr Ser Leu Thr Gly Lys Gln Ser Ser 
    210                 215                 220                 


Ala Glu Ser Asp Ala Trp Val Leu Gln Phe Gly Glu Ala Glu Asn Arg 
225                 230                 235                 240 


Leu Leu Met Gly Gly Cys Arg Asn Lys Cys Leu Ser Val Leu Lys Thr 
                245                 250                 255     


Leu Arg Asp Arg His Leu Glu Leu Pro Gly Gln Pro Leu Asn Asn Tyr 
            260                 265                 270         


His Met Lys Thr Leu Leu Leu Tyr Glu Cys Glu Lys His Pro Arg Glu 
        275                 280                 285             


Thr Asp Trp Asp Glu Ser Cys Leu Gly Asp Arg Leu Asn Gly Ile Leu 
    290                 295                 300                 


Leu Gln Leu Ile Ser Cys Leu Gln Cys Arg Arg Cys Pro His Tyr Phe 
305                 310                 315                 320 


Leu Pro Asn Leu Asp Leu Phe Gln Gly Lys Pro His Ser Ala Leu Glu 
                325                 330                 335     


Ser Ala Ala Lys Gln Thr Trp Arg Leu Ala Arg Glu Ile Leu Thr Asn 
            340                 345                 350         


Pro Lys Ser Leu Asp Lys Leu 
        355                 


<210>  220
<211>  380
<212>  PRT
<213>  Homo sapiens

<400>  220

Met Glu Glu Ile Tyr Ala Lys Phe Val Ser Gln Lys Ile Ser Lys Thr 
1               5                   10                  15      


Arg Trp Arg Pro Leu Pro Pro Gly Ser Leu Gln Thr Ala Glu Thr Phe 
            20                  25                  30          


Ala Thr Gly Ser Trp Asp Asn Glu Glu Asn Tyr Ile Ser Leu Trp Ser 
        35                  40                  45              


Ile Gly Asp Phe Gly Asn Leu Asp Ser Asp Gly Gly Phe Glu Gly Asp 
    50                  55                  60                  


His Gln Leu Leu Cys Asp Ile Arg His His Gly Asp Val Met Asp Leu 
65                  70                  75                  80  


Gln Phe Phe Asp Gln Glu Arg Ile Val Ala Ala Ser Ser Thr Gly Cys 
                85                  90                  95      


Val Thr Val Phe Leu His His Pro Asn Asn Gln Thr Leu Ser Val Asn 
            100                 105                 110         


Gln Gln Trp Thr Thr Ala His Tyr His Thr Gly Pro Gly Ser Pro Ser 
        115                 120                 125             


Tyr Ser Ser Ala Pro Cys Thr Gly Val Val Cys Asn Asn Pro Glu Ile 
    130                 135                 140                 


Val Thr Val Gly Glu Asp Gly Arg Ile Asn Leu Phe Arg Ala Asp His 
145                 150                 155                 160 


Lys Glu Ala Val Arg Thr Ile Asp Asn Ala Asp Ser Ser Thr Leu His 
                165                 170                 175     


Ala Val Thr Phe Leu Arg Thr Pro Glu Ile Leu Thr Val Asn Ser Ile 
            180                 185                 190         


Gly Gln Leu Lys Ile Trp Asp Phe Arg Gln Gln Gly Asn Glu Pro Ser 
        195                 200                 205             


Gln Ile Leu Ser Leu Thr Gly Asp Arg Val Pro Leu His Cys Val Asp 
    210                 215                 220                 


Arg His Pro Asn Gln Gln His Val Val Ala Thr Gly Gly Gln Asp Gly 
225                 230                 235                 240 


Met Leu Ser Ile Trp Asp Val Arg Gln Gly Thr Met Pro Val Ser Leu 
                245                 250                 255     


Leu Lys Ala His Glu Ala Glu Met Trp Glu Val His Phe His Pro Ser 
            260                 265                 270         


Asn Pro Glu His Leu Phe Thr Cys Ser Glu Asp Gly Ser Leu Trp His 
        275                 280                 285             


Trp Asp Ala Ser Thr Asp Val Pro Glu Lys Ser Ser Leu Phe His Gln 
    290                 295                 300                 


Gly Gly Arg Ser Ser Thr Phe Leu Ser His Ser Ile Ser Asn Gln Ala 
305                 310                 315                 320 


Asn Val His Gln Ser Val Ile Ser Ser Trp Leu Ser Thr Asp Pro Ala 
                325                 330                 335     


Lys Asp Arg Ile Glu Ile Thr Ser Leu Leu Pro Ser Arg Ser Leu Ser 
            340                 345                 350         


Val Asn Thr Leu Asp Val Leu Gly Pro Cys Leu Val Cys Gly Thr Asp 
        355                 360                 365             


Ala Glu Ala Ile Tyr Val Thr Arg His Leu Phe Ser 
    370                 375                 380 


<210>  221
<211>  142
<212>  PRT
<213>  Homo sapiens

<400>  221

Met Ser Leu Thr Lys Thr Glu Arg Thr Ile Ile Val Ser Met Trp Ala 
1               5                   10                  15      


Lys Ile Ser Thr Gln Ala Asp Thr Ile Gly Thr Glu Thr Leu Glu Arg 
            20                  25                  30          


Leu Phe Leu Ser His Pro Gln Thr Lys Thr Tyr Phe Pro His Phe Asp 
        35                  40                  45              


Leu His Pro Gly Ser Ala Gln Leu Arg Ala His Gly Ser Lys Val Val 
    50                  55                  60                  


Ala Ala Val Gly Asp Ala Val Lys Ser Ile Asp Asp Ile Gly Gly Ala 
65                  70                  75                  80  


Leu Ser Lys Leu Ser Glu Leu His Ala Tyr Ile Leu Arg Val Asp Pro 
                85                  90                  95      


Val Asn Phe Lys Leu Leu Ser His Cys Leu Leu Val Thr Leu Ala Ala 
            100                 105                 110         


Arg Phe Pro Ala Asp Phe Thr Ala Glu Ala His Ala Ala Trp Asp Lys 
        115                 120                 125             


Phe Leu Ser Val Val Ser Ser Val Leu Thr Glu Lys Tyr Arg 
    130                 135                 140         


<210>  222
<211>  467
<212>  PRT
<213>  Homo sapiens

<400>  222

Met Ala Leu His Pro Arg Arg Val Arg Leu Lys Pro Trp Leu Val Ala 
1               5                   10                  15      


Gln Val Asp Ser Gly Leu Tyr Pro Gly Leu Ile Trp Leu His Arg Asp 
            20                  25                  30          


Ser Lys Arg Phe Gln Ile Pro Trp Lys His Ala Thr Arg His Ser Pro 
        35                  40                  45              


Gln Gln Glu Glu Glu Asn Thr Ile Phe Lys Ala Trp Ala Val Glu Thr 
    50                  55                  60                  


Gly Lys Tyr Gln Glu Gly Val Asp Asp Pro Asp Pro Ala Lys Trp Lys 
65                  70                  75                  80  


Ala Gln Leu Arg Cys Ala Leu Asn Lys Ser Arg Glu Phe Asn Leu Met 
                85                  90                  95      


Tyr Asp Gly Thr Lys Glu Val Pro Met Asn Pro Val Lys Ile Tyr Gln 
            100                 105                 110         


Val Cys Asp Ile Pro Gln Pro Gln Gly Ser Ile Ile Asn Pro Gly Ser 
        115                 120                 125             


Thr Gly Ser Ala Pro Trp Asp Glu Lys Asp Asn Asp Val Asp Glu Glu 
    130                 135                 140                 


Asp Glu Glu Asp Glu Leu Asp Gln Ser Gln His His Val Pro Ile Gln 
145                 150                 155                 160 


Asp Thr Phe Pro Phe Leu Asn Ile Asn Gly Ser Pro Met Ala Pro Ala 
                165                 170                 175     


Ser Val Gly Asn Cys Ser Val Gly Asn Cys Ser Pro Glu Ala Val Trp 
            180                 185                 190         


Pro Lys Thr Glu Pro Leu Glu Met Glu Val Pro Gln Ala Pro Ile Gln 
        195                 200                 205             


Pro Phe Tyr Ser Ser Pro Glu Leu Trp Ile Ser Ser Leu Pro Met Thr 
    210                 215                 220                 


Asp Leu Asp Ile Lys Phe Gln Tyr Arg Gly Lys Glu Tyr Gly Gln Thr 
225                 230                 235                 240 


Met Thr Val Ser Asn Pro Gln Gly Cys Arg Leu Phe Tyr Gly Asp Leu 
                245                 250                 255     


Gly Pro Met Pro Asp Gln Glu Glu Leu Phe Gly Pro Val Ser Leu Glu 
            260                 265                 270         


Gln Val Lys Phe Pro Gly Pro Glu His Ile Thr Asn Glu Lys Gln Lys 
        275                 280                 285             


Leu Phe Thr Ser Lys Leu Leu Asp Val Met Asp Arg Gly Leu Ile Leu 
    290                 295                 300                 


Glu Val Ser Gly His Ala Ile Tyr Ala Ile Arg Leu Cys Gln Cys Lys 
305                 310                 315                 320 


Val Tyr Trp Ser Gly Pro Cys Ala Pro Ser Leu Val Ala Pro Asn Leu 
                325                 330                 335     


Ile Glu Arg Gln Lys Lys Val Lys Leu Phe Cys Leu Glu Thr Phe Leu 
            340                 345                 350         


Ser Asp Leu Ile Ala His Gln Lys Gly Gln Ile Glu Lys Gln Pro Pro 
        355                 360                 365             


Phe Glu Ile Tyr Leu Cys Phe Gly Glu Glu Trp Pro Asp Gly Lys Pro 
    370                 375                 380                 


Leu Glu Arg Lys Leu Ile Leu Val Gln Val Ile Pro Val Val Ala Arg 
385                 390                 395                 400 


Met Ile Tyr Glu Met Phe Ser Gly Asp Phe Thr Arg Ser Phe Asp Ser 
                405                 410                 415     


Gly Ser Val Arg Leu Gln Ile Ser Thr Pro Asp Ile Lys Asp Asn Ile 
            420                 425                 430         


Val Ala Gln Leu Lys Gln Leu Tyr Arg Ile Leu Gln Thr Gln Glu Ser 
        435                 440                 445             


Trp Gln Pro Met Gln Pro Thr Pro Ser Met Gln Leu Pro Pro Ala Leu 
    450                 455                 460                 


Pro Pro Gln 
465         


<210>  223
<211>  117
<212>  PRT
<213>  Homo sapiens

<400>  223

Met Pro Leu Pro Pro Cys Val Val Ser Thr Leu Gln Asp Phe Ile Leu 
1               5                   10                  15      


Gly His Pro Lys Ala Glu Asp Ile Ala Gly Gln Gln Glu Ile His Gly 
            20                  25                  30          


Ala Ser Arg Lys Thr Ser Lys Arg Trp Trp Ser Arg Gly Arg His Thr 
        35                  40                  45              


Gln Thr Ala Val Cys Asn Cys Ala Ala Ala Gly Cys Cys Gly Cys Trp 
    50                  55                  60                  


Pro Ala Val His Ser Gly His Thr Gly Leu Cys His Arg Met Gln Ala 
65                  70                  75                  80  


Val Ala Gly Gly Gly Thr Ala Gly Arg Gln Gly Leu Cys Ala Trp Lys 
                85                  90                  95      


Pro Ala Gly Leu Leu Gln Glu Glu Gly Cys Arg Met Leu Gln Leu Arg 
            100                 105                 110         


Pro Asp Ser Gly Phe 
        115         


<210>  224
<211>  348
<212>  PRT
<213>  Homo sapiens

<400>  224

Met Ala Glu Lys Val Leu Val Thr Gly Gly Ala Gly Tyr Ile Gly Ser 
1               5                   10                  15      


His Thr Val Leu Glu Leu Leu Glu Ala Gly Tyr Leu Pro Val Val Ile 
            20                  25                  30          


Asp Asn Phe His Asn Ala Phe Arg Gly Gly Gly Ser Leu Pro Glu Ser 
        35                  40                  45              


Leu Arg Arg Val Gln Glu Leu Thr Gly Arg Ser Val Glu Phe Glu Glu 
    50                  55                  60                  


Met Asp Ile Leu Asp Gln Gly Ala Leu Gln Arg Leu Phe Lys Lys Tyr 
65                  70                  75                  80  


Ser Phe Met Ala Val Ile His Phe Ala Gly Leu Lys Ala Val Gly Glu 
                85                  90                  95      


Ser Val Gln Lys Pro Leu Asp Tyr Tyr Arg Val Asn Leu Thr Gly Thr 
            100                 105                 110         


Ile Gln Leu Leu Glu Ile Met Lys Ala His Gly Val Lys Asn Leu Val 
        115                 120                 125             


Phe Ser Ser Ser Ala Thr Val Tyr Gly Asn Pro Gln Tyr Leu Pro Leu 
    130                 135                 140                 


Asp Glu Ala His Pro Thr Gly Gly Cys Thr Asn Pro Tyr Gly Lys Ser 
145                 150                 155                 160 


Lys Phe Phe Ile Glu Glu Met Ile Arg Asp Leu Cys Gln Ala Asp Lys 
                165                 170                 175     


Thr Trp Asn Ala Val Leu Leu Arg Tyr Phe Asn Pro Thr Gly Ala His 
            180                 185                 190         


Ala Ser Gly Cys Ile Gly Glu Asp Pro Gln Gly Ile Pro Asn Asn Leu 
        195                 200                 205             


Met Pro Tyr Val Ser Gln Val Ala Ile Gly Arg Arg Glu Ala Leu Asn 
    210                 215                 220                 


Val Phe Gly Asn Asp Tyr Asp Thr Glu Asp Gly Thr Gly Val Arg Asp 
225                 230                 235                 240 


Tyr Ile His Val Val Asp Leu Ala Lys Gly His Ile Ala Ala Leu Arg 
                245                 250                 255     


Lys Leu Lys Glu Gln Cys Gly Cys Arg Ile Tyr Asn Leu Gly Thr Gly 
            260                 265                 270         


Thr Gly Tyr Ser Val Leu Gln Met Val Gln Ala Met Glu Lys Ala Ser 
        275                 280                 285             


Gly Lys Lys Ile Pro Tyr Lys Val Val Ala Arg Arg Glu Gly Asp Val 
    290                 295                 300                 


Ala Ala Cys Tyr Ala Asn Pro Ser Leu Ala Gln Glu Glu Leu Gly Trp 
305                 310                 315                 320 


Thr Ala Ala Leu Gly Leu Asp Arg Met Cys Glu Asp Leu Trp Arg Trp 
                325                 330                 335     


Gln Lys Gln Asn Pro Ser Gly Phe Gly Thr Gln Ala 
            340                 345             


<210>  225
<211>  214
<212>  PRT
<213>  Homo sapiens

<400>  225

Met Ala Gly Glu Asn Phe Ala Thr Pro Phe His Gly His Val Gly Arg 
1               5                   10                  15      


Gly Ala Phe Ser Asp Val Tyr Glu Pro Ala Glu Asp Thr Phe Leu Leu 
            20                  25                  30          


Leu Asp Ala Leu Glu Ala Ala Ala Ala Glu Leu Ala Gly Val Glu Ile 
        35                  40                  45              


Cys Leu Glu Val Gly Ser Gly Ser Gly Val Val Ser Ala Phe Leu Ala 
    50                  55                  60                  


Ser Met Ile Gly Pro Gln Ala Leu Tyr Met Cys Thr Asp Ile Asn Pro 
65                  70                  75                  80  


Glu Ala Ala Ala Cys Thr Leu Glu Thr Ala Arg Cys Asn Lys Val His 
                85                  90                  95      


Ile Gln Pro Val Ile Thr Asp Leu Val Lys Gly Leu Leu Pro Arg Leu 
            100                 105                 110         


Thr Glu Lys Val Asp Leu Leu Val Phe Asn Pro Pro Tyr Val Val Thr 
        115                 120                 125             


Pro Pro Gln Glu Val Gly Ser His Gly Ile Glu Ala Ala Trp Ala Gly 
    130                 135                 140                 


Gly Lys Asn Gly Arg Glu Val Met Asp Arg Phe Phe Pro Leu Val Pro 
145                 150                 155                 160 


Asp Leu Leu Ser Pro Lys Gly Leu Phe Tyr Leu Val Thr Ile Lys Glu 
                165                 170                 175     


Asn Asn Pro Glu Glu Ile Leu Lys Ile Met Lys Thr Lys Gly Leu Gln 
            180                 185                 190         


Gly Thr Thr Ala Leu Ser Arg Gln Ala Gly Gln Glu Thr Leu Ser Val 
        195                 200                 205             


Leu Lys Phe Thr Lys Ser 
    210                 


<210>  226
<211>  642
<212>  PRT
<213>  Homo sapiens

<400>  226

Met Ala Glu Ala Ala Pro Ala Pro Thr Ser Glu Trp Asp Ser Glu Cys 
1               5                   10                  15      


Leu Thr Ser Leu Gln Pro Leu Pro Leu Pro Thr Pro Pro Ala Ala Asn 
            20                  25                  30          


Glu Ala His Leu Gln Thr Ala Ala Ile Ser Leu Trp Thr Val Val Ala 
        35                  40                  45              


Ala Val Gln Ala Ile Glu Arg Lys Val Glu Ile His Ser Arg Arg Leu 
    50                  55                  60                  


Leu His Leu Glu Gly Arg Thr Gly Thr Ala Glu Lys Lys Leu Ala Ser 
65                  70                  75                  80  


Cys Glu Lys Thr Val Thr Glu Leu Gly Asn Gln Leu Glu Gly Lys Trp 
                85                  90                  95      


Ala Val Leu Gly Thr Leu Leu Gln Glu Tyr Gly Leu Leu Gln Arg Arg 
            100                 105                 110         


Leu Glu Asn Leu Glu Asn Leu Leu Arg Asn Arg Asn Phe Trp Ile Leu 
        115                 120                 125             


Arg Leu Pro Pro Gly Ile Lys Gly Asp Ile Pro Lys Val Pro Val Ala 
    130                 135                 140                 


Phe Asp Asp Val Ser Ile Tyr Phe Ser Thr Pro Glu Trp Glu Lys Leu 
145                 150                 155                 160 


Glu Glu Trp Gln Lys Glu Leu Tyr Lys Asn Ile Met Lys Gly Asn Tyr 
                165                 170                 175     


Glu Ser Leu Ile Ser Met Asp Tyr Ala Ile Asn Gln Pro Asp Val Leu 
            180                 185                 190         


Ser Gln Ile Gln Pro Glu Gly Glu His Asn Thr Glu Asp Gln Ala Gly 
        195                 200                 205             


Pro Glu Glu Ser Glu Ile Pro Thr Asp Pro Ser Glu Glu Pro Gly Ile 
    210                 215                 220                 


Ser Thr Ser Asp Ile Leu Ser Trp Ile Lys Gln Glu Glu Glu Pro Gln 
225                 230                 235                 240 


Val Gly Ala Pro Pro Glu Ser Lys Glu Ser Asp Val Tyr Lys Ser Thr 
                245                 250                 255     


Tyr Ala Asp Glu Glu Leu Val Ile Lys Ala Glu Gly Leu Ala Arg Ser 
            260                 265                 270         


Ser Leu Cys Pro Glu Val Pro Val Pro Phe Ser Ser Pro Pro Ala Ala 
        275                 280                 285             


Ala Lys Asp Ala Phe Ser Asp Val Ala Phe Lys Ser Gln Gln Ser Thr 
    290                 295                 300                 


Ser Met Thr Pro Phe Gly Arg Pro Ala Thr Asp Leu Pro Glu Ala Ser 
305                 310                 315                 320 


Glu Gly Gln Val Thr Phe Thr Gln Leu Gly Ser Tyr Pro Leu Pro Pro 
                325                 330                 335     


Pro Val Gly Glu Gln Val Phe Ser Cys His His Cys Gly Lys Asn Leu 
            340                 345                 350         


Ser Gln Asp Met Leu Leu Thr His Gln Cys Ser His Ala Thr Glu His 
        355                 360                 365             


Pro Leu Pro Cys Ala Gln Cys Pro Lys His Phe Thr Pro Gln Ala Asp 
    370                 375                 380                 


Leu Ser Ser Thr Ser Gln Asp His Ala Ser Glu Thr Pro Pro Thr Cys 
385                 390                 395                 400 


Pro His Cys Ala Arg Thr Phe Thr His Pro Ser Arg Leu Thr Tyr His 
                405                 410                 415     


Leu Arg Val His Asn Ser Thr Glu Arg Pro Phe Pro Cys Pro Asp Cys 
            420                 425                 430         


Pro Lys Arg Phe Ala Asp Gln Ala Arg Leu Thr Ser His Arg Arg Ala 
        435                 440                 445             


His Ala Ser Glu Arg Pro Phe Arg Cys Ala Gln Cys Gly Arg Ser Phe 
    450                 455                 460                 


Ser Leu Lys Ile Ser Leu Leu Leu His Gln Arg Gly His Ala Gln Glu 
465                 470                 475                 480 


Arg Pro Phe Ser Cys Pro Gln Cys Gly Ile Asp Phe Asn Gly His Ser 
                485                 490                 495     


Ala Leu Ile Arg His Gln Met Ile His Thr Gly Glu Arg Pro Tyr Pro 
            500                 505                 510         


Cys Thr Asp Cys Ser Lys Ser Phe Met Arg Lys Glu His Leu Leu Asn 
        515                 520                 525             


His Arg Arg Leu His Thr Gly Glu Arg Pro Phe Ser Cys Pro His Cys 
    530                 535                 540                 


Gly Lys Ser Phe Ile Arg Lys His His Leu Met Lys His Gln Arg Ile 
545                 550                 555                 560 


His Thr Gly Glu Arg Pro Tyr Pro Cys Ser Tyr Cys Gly Arg Ser Phe 
                565                 570                 575     


Arg Tyr Lys Gln Thr Leu Lys Asp His Leu Arg Ser Gly His Asn Gly 
            580                 585                 590         


Gly Cys Gly Gly Asp Ser Asp Pro Ser Gly Gln Pro Pro Asn Pro Pro 
        595                 600                 605             


Gly Pro Leu Ile Thr Gly Leu Glu Thr Ser Gly Leu Gly Val Asn Thr 
    610                 615                 620                 


Glu Gly Leu Glu Thr Asn Gln Trp Tyr Gly Glu Gly Ser Gly Gly Gly 
625                 630                 635                 640 


Val Leu 
        


<210>  227
<211>  331
<212>  PRT
<213>  Homo sapiens

<400>  227

Met Ser Gly Glu Asn Val Thr Arg Val Gly Thr Phe Ile Leu Val Gly 
1               5                   10                  15      


Phe Pro Thr Ala Pro Gly Leu Gln Tyr Leu Leu Phe Leu Leu Phe Leu 
            20                  25                  30          


Leu Thr Tyr Leu Phe Val Leu Val Glu Asn Leu Ala Ile Ile Leu Thr 
        35                  40                  45              


Val Trp Ser Ser Thr Ser Leu His Arg Pro Met Tyr Tyr Phe Leu Ser 
    50                  55                  60                  


Ser Met Ser Phe Leu Glu Ile Trp Tyr Val Ser Asp Ile Thr Pro Lys 
65                  70                  75                  80  


Met Leu Glu Gly Phe Leu Leu Gln Gln Lys Arg Ile Ser Phe Val Gly 
                85                  90                  95      


Cys Met Thr Gln Leu Tyr Phe Phe Ser Ser Leu Val Cys Thr Glu Cys 
            100                 105                 110         


Val Leu Leu Ala Ser Met Ala Tyr Asp Arg Tyr Val Ala Ile Cys His 
        115                 120                 125             


Pro Leu Arg Tyr His Val Leu Val Thr Pro Gly Leu Cys Leu Gln Leu 
    130                 135                 140                 


Val Gly Phe Ser Phe Val Ser Gly Phe Thr Ile Ser Met Ile Lys Val 
145                 150                 155                 160 


Cys Phe Ile Ser Ser Val Thr Phe Cys Gly Ser Asn Val Leu Asn His 
                165                 170                 175     


Phe Phe Cys Asp Ile Ser Pro Ile Leu Lys Leu Ala Cys Thr Asp Phe 
            180                 185                 190         


Ser Thr Ala Glu Leu Val Asp Phe Ile Leu Ala Phe Ile Ile Leu Val 
        195                 200                 205             


Phe Pro Leu Leu Ala Thr Met Leu Ser Tyr Ala His Ile Thr Leu Ala 
    210                 215                 220                 


Val Leu Arg Ile Pro Ser Ala Thr Gly Cys Trp Arg Ala Phe Phe Thr 
225                 230                 235                 240 


Cys Ala Ser His Leu Thr Val Val Thr Val Phe Tyr Thr Ala Leu Leu 
                245                 250                 255     


Phe Met Tyr Val Arg Pro Gln Ala Ile Asp Ser Arg Ser Ser Asn Lys 
            260                 265                 270         


Leu Ile Ser Val Leu Tyr Thr Val Ile Thr Pro Ile Leu Asn Pro Leu 
        275                 280                 285             


Ile Tyr Cys Leu Arg Asn Lys Glu Phe Lys Asn Ala Leu Lys Lys Ala 
    290                 295                 300                 


Phe Gly Leu Thr Ser Cys Ala Val Glu Gly Arg Leu Ser Ser Leu Leu 
305                 310                 315                 320 


Glu Leu His Leu Gln Ile His Ser Gln Pro Leu 
                325                 330     


<210>  228
<211>  676
<212>  PRT
<213>  Homo sapiens

<400>  228

Met Ala Pro Phe Leu Arg Ile Ala Phe Asn Ser Tyr Glu Leu Gly Ser 
1               5                   10                  15      


Leu Gln Ala Glu Asp Glu Ala Asn Gln Pro Phe Cys Ala Val Lys Met 
            20                  25                  30          


Lys Glu Ala Leu Ser Thr Glu Arg Gly Lys Thr Leu Val Gln Lys Lys 
        35                  40                  45              


Pro Thr Met Tyr Pro Glu Trp Lys Ser Thr Phe Asp Ala His Ile Tyr 
    50                  55                  60                  


Glu Gly Arg Val Ile Gln Ile Val Leu Met Arg Ala Ala Glu Glu Pro 
65                  70                  75                  80  


Val Ser Glu Val Thr Val Gly Val Ser Val Leu Ala Glu Arg Cys Lys 
                85                  90                  95      


Lys Asn Asn Gly Lys Ala Glu Phe Trp Leu Asp Leu Gln Pro Gln Ala 
            100                 105                 110         


Lys Val Leu Met Ser Val Gln Tyr Phe Leu Glu Asp Val Asp Cys Lys 
        115                 120                 125             


Gln Ser Met Arg Ser Glu Asp Glu Ala Lys Phe Pro Thr Met Asn Arg 
    130                 135                 140                 


Arg Gly Ala Ile Lys Gln Ala Lys Ile His Tyr Ile Lys Asn His Glu 
145                 150                 155                 160 


Phe Ile Ala Thr Phe Phe Gly Gln Pro Thr Phe Cys Ser Val Cys Lys 
                165                 170                 175     


Asp Phe Val Trp Gly Leu Asn Lys Gln Gly Tyr Lys Cys Arg Gln Cys 
            180                 185                 190         


Asn Ala Ala Ile His Lys Lys Cys Ile Asp Lys Ile Ile Gly Arg Cys 
        195                 200                 205             


Thr Gly Thr Ala Ala Asn Ser Arg Asp Thr Ile Phe Gln Lys Glu Arg 
    210                 215                 220                 


Phe Asn Ile Asp Met Pro His Arg Phe Lys Val His Asn Tyr Met Ser 
225                 230                 235                 240 


Pro Thr Phe Cys Asp His Cys Gly Ser Leu Leu Trp Gly Leu Val Lys 
                245                 250                 255     


Gln Gly Leu Lys Cys Glu Asp Cys Gly Met Asn Val His His Lys Cys 
            260                 265                 270         


Arg Glu Lys Val Ala Asn Leu Cys Gly Ile Asn Gln Lys Leu Leu Ala 
        275                 280                 285             


Glu Ala Leu Asn Gln Val Thr Gln Arg Ala Ser Arg Arg Ser Asp Ser 
    290                 295                 300                 


Ala Ser Ser Glu Pro Val Gly Ile Tyr Gln Gly Phe Glu Lys Lys Thr 
305                 310                 315                 320 


Gly Val Ala Gly Glu Asp Met Gln Asp Asn Ser Gly Thr Tyr Gly Lys 
                325                 330                 335     


Ile Trp Glu Gly Ser Ser Lys Cys Asn Ile Asn Asn Phe Ile Phe His 
            340                 345                 350         


Lys Val Leu Gly Lys Gly Ser Phe Gly Lys Val Leu Leu Gly Glu Leu 
        355                 360                 365             


Lys Gly Arg Gly Glu Tyr Phe Ala Ile Lys Ala Leu Lys Lys Asp Val 
    370                 375                 380                 


Val Leu Ile Asp Asp Asp Val Glu Cys Thr Met Val Glu Lys Arg Val 
385                 390                 395                 400 


Leu Thr Leu Ala Ala Glu Asn Pro Phe Leu Thr His Leu Ile Cys Thr 
                405                 410                 415     


Phe Gln Thr Lys Asp His Leu Phe Phe Val Met Glu Phe Leu Asn Gly 
            420                 425                 430         


Gly Asp Leu Met Tyr His Ile Gln Asp Lys Gly Arg Phe Glu Leu Tyr 
        435                 440                 445             


Arg Ala Thr Phe Tyr Ala Ala Glu Ile Met Cys Gly Leu Gln Phe Leu 
    450                 455                 460                 


His Ser Lys Gly Ile Ile Tyr Arg Asp Leu Lys Leu Asp Asn Val Leu 
465                 470                 475                 480 


Leu Asp Arg Asp Gly His Ile Lys Ile Ala Asp Phe Gly Met Cys Lys 
                485                 490                 495     


Glu Asn Ile Phe Gly Glu Ser Arg Ala Ser Thr Phe Cys Gly Thr Pro 
            500                 505                 510         


Asp Tyr Ile Ala Pro Glu Ile Leu Gln Gly Leu Lys Tyr Thr Phe Ser 
        515                 520                 525             


Val Asp Trp Trp Ser Phe Gly Val Leu Leu Tyr Glu Met Leu Ile Gly 
    530                 535                 540                 


Gln Ser Pro Phe His Gly Asp Asp Glu Asp Glu Leu Phe Glu Ser Ile 
545                 550                 555                 560 


Arg Val Asp Thr Pro His Tyr Pro Arg Trp Ile Thr Lys Glu Ser Lys 
                565                 570                 575     


Asp Ile Leu Glu Lys Leu Phe Glu Arg Glu Pro Thr Lys Arg Leu Gly 
            580                 585                 590         


Val Thr Gly Asn Ile Lys Ile His Pro Phe Phe Lys Thr Ile Asn Trp 
        595                 600                 605             


Thr Leu Leu Glu Lys Arg Arg Leu Glu Pro Pro Phe Arg Pro Lys Val 
    610                 615                 620                 


Lys Ser Pro Arg Asp Tyr Ser Asn Phe Asp Gln Glu Phe Leu Asn Glu 
625                 630                 635                 640 


Lys Ala Arg Leu Ser Tyr Ser Asp Lys Asn Leu Ile Asp Ser Met Asp 
                645                 650                 655     


Gln Ser Ala Phe Ala Gly Phe Ser Phe Val Asn Pro Lys Phe Glu His 
            660                 665                 670         


Leu Leu Glu Asp 
        675     


<210>  229
<211>  309
<212>  PRT
<213>  Homo sapiens

<400>  229

Met Ser Pro Ser Pro Ser Asn Ser Tyr Asp Thr Ser Pro Gln Pro Cys 
1               5                   10                  15      


Thr Thr Asn Gln Asn Gly Arg Glu Asn Asn Glu Arg Leu Ser Thr Ser 
            20                  25                  30          


Asn Gly Lys Met Ser Pro Thr Arg Tyr His Ala Asn Ser Met Gly Gln 
        35                  40                  45              


Arg Ser Tyr Ser Phe Glu Ala Ser Glu Glu Asp Leu Asp Val Asp Asp 
    50                  55                  60                  


Lys Val Glu Glu Leu Met Arg Arg Asp Ser Ser Val Ile Lys Glu Glu 
65                  70                  75                  80  


Ile Lys Ala Phe Leu Ala Asn Arg Arg Ile Ser Gln Ala Val Val Ala 
                85                  90                  95      


Gln Val Thr Gly Ile Ser Gln Ser Arg Ile Ser His Trp Leu Leu Gln 
            100                 105                 110         


Gln Gly Ser Asp Leu Ser Glu Gln Lys Lys Arg Ala Phe Tyr Arg Trp 
        115                 120                 125             


Tyr Gln Leu Glu Lys Thr Asn Pro Gly Ala Thr Leu Ser Met Arg Pro 
    130                 135                 140                 


Ala Pro Ile Pro Ile Glu Asp Pro Glu Trp Arg Gln Thr Pro Pro Pro 
145                 150                 155                 160 


Val Ser Ala Thr Ser Gly Thr Phe Arg Leu Arg Arg Gly Ser Arg Phe 
                165                 170                 175     


Thr Trp Arg Lys Glu Cys Leu Ala Val Met Glu Ser Tyr Phe Asn Glu 
            180                 185                 190         


Asn Gln Tyr Pro Asp Glu Ala Lys Arg Glu Glu Ile Ala Asn Ala Cys 
        195                 200                 205             


Asn Ala Val Ile Gln Lys Pro Gly Lys Lys Leu Ser Asp Leu Glu Arg 
    210                 215                 220                 


Val Thr Ser Leu Lys Val Tyr Asn Trp Phe Ala Asn Arg Arg Lys Glu 
225                 230                 235                 240 


Ile Lys Arg Arg Ala Asn Ile Ala Ala Ile Leu Glu Ser His Gly Ile 
                245                 250                 255     


Asp Val Gln Ser Pro Gly Gly His Ser Asn Ser Asp Asp Val Asp Gly 
            260                 265                 270         


Asn Asp Tyr Ser Glu Gln Asp Thr Trp Gln Val Arg Asn Gly Glu Glu 
        275                 280                 285             


Glu Glu Gly Arg Ser Ser Glu Gly Gly Arg Glu Ala Glu Lys Val Glu 
    290                 295                 300                 


Glu Glu Arg Arg Ile 
305                 


<210>  230
<211>  427
<212>  PRT
<213>  Homo sapiens

<400>  230

Met Gln Gly Leu Leu Thr Ser Gly Arg Lys Pro Ser Gly Gly Gly Arg 
1               5                   10                  15      


Cys Thr Gly Arg Gly Gly Trp Arg Gly Gln Trp Cys Leu Lys Pro Trp 
            20                  25                  30          


Met Gly Gly Ala Asp Pro Pro Thr Pro Thr Leu Ser Cys Leu Leu Leu 
        35                  40                  45              


Pro Val Pro Pro Glu Leu Pro Asp His Cys Tyr Arg Met Asn Ser Ser 
    50                  55                  60                  


Pro Ala Gly Thr Pro Ser Pro Gln Pro Ser Arg Ala Asn Gly Asn Ile 
65                  70                  75                  80  


Asn Leu Gly Pro Ser Ala Asn Pro Asn Ala Gln Pro Thr Asp Phe Asp 
                85                  90                  95      


Phe Leu Lys Val Ile Gly Lys Gly Asn Tyr Gly Lys Val Leu Leu Ala 
            100                 105                 110         


Lys Arg Lys Ser Asp Gly Ala Phe Tyr Ala Val Lys Val Leu Gln Lys 
        115                 120                 125             


Lys Ser Ile Leu Lys Lys Lys Glu Gln Ser His Ile Met Ala Glu Arg 
    130                 135                 140                 


Ser Val Leu Leu Lys Asn Val Arg His Pro Phe Leu Val Gly Leu Arg 
145                 150                 155                 160 


Tyr Ser Phe Gln Thr Pro Glu Lys Leu Tyr Phe Val Leu Asp Tyr Val 
                165                 170                 175     


Asn Gly Gly Glu Leu Phe Phe His Leu Gln Arg Glu Arg Arg Phe Leu 
            180                 185                 190         


Glu Pro Arg Ala Arg Phe Tyr Ala Ala Glu Val Ala Ser Ala Ile Gly 
        195                 200                 205             


Tyr Leu His Ser Leu Asn Ile Ile Tyr Arg Asp Leu Lys Pro Glu Asn 
    210                 215                 220                 


Ile Leu Leu Asp Cys Gln Gly His Val Val Leu Thr Asp Phe Gly Leu 
225                 230                 235                 240 


Cys Lys Glu Gly Val Glu Pro Glu Asp Thr Thr Ser Thr Phe Cys Gly 
                245                 250                 255     


Thr Pro Glu Tyr Leu Ala Pro Glu Val Leu Arg Lys Glu Pro Tyr Asp 
            260                 265                 270         


Arg Ala Val Asp Trp Trp Cys Leu Gly Ala Val Leu Tyr Glu Met Leu 
        275                 280                 285             


His Gly Leu Pro Pro Phe Tyr Ser Gln Asp Val Ser Gln Met Tyr Glu 
    290                 295                 300                 


Asn Ile Leu His Gln Pro Leu Gln Ile Pro Gly Gly Arg Thr Val Ala 
305                 310                 315                 320 


Ala Cys Asp Leu Leu Gln Ser Leu Leu His Lys Asp Gln Arg Gln Arg 
                325                 330                 335     


Leu Gly Ser Lys Ala Asp Phe Leu Glu Ile Lys Asn His Val Phe Phe 
            340                 345                 350         


Ser Pro Ile Asn Trp Asp Asp Leu Tyr His Lys Arg Leu Thr Pro Pro 
        355                 360                 365             


Phe Asn Pro Asn Val Thr Gly Pro Ala Asp Leu Lys His Phe Asp Pro 
    370                 375                 380                 


Glu Phe Thr Gln Glu Ala Val Ser Lys Ser Ile Gly Cys Thr Pro Asp 
385                 390                 395                 400 


Thr Val Ala Ser Ser Ser Gly Ala Ser Ser Ala Phe Leu Gly Phe Ser 
                405                 410                 415     


Tyr Ala Pro Glu Asp Asp Asp Ile Leu Asp Cys 
            420                 425         


<210>  231
<211>  311
<212>  PRT
<213>  Homo sapiens

<400>  231

Met Gly Val Pro Thr Ala Leu Glu Ala Gly Ser Trp Arg Trp Gly Ser 
1               5                   10                  15      


Leu Leu Phe Ala Leu Phe Leu Ala Ala Ser Leu Gly Pro Val Ala Ala 
            20                  25                  30          


Phe Lys Val Ala Thr Pro Tyr Ser Leu Tyr Val Cys Pro Glu Gly Gln 
        35                  40                  45              


Asn Val Thr Leu Thr Cys Arg Leu Leu Gly Pro Val Asp Lys Gly His 
    50                  55                  60                  


Asp Val Thr Phe Tyr Lys Thr Trp Tyr Arg Ser Ser Arg Gly Glu Val 
65                  70                  75                  80  


Gln Thr Cys Ser Glu Arg Arg Pro Ile Arg Asn Leu Thr Phe Gln Asp 
                85                  90                  95      


Leu His Leu His His Gly Gly His Gln Ala Ala Asn Thr Ser His Asp 
            100                 105                 110         


Leu Ala Gln Arg His Gly Leu Glu Ser Ala Ser Asp His His Gly Asn 
        115                 120                 125             


Phe Ser Ile Thr Met Arg Asn Leu Thr Leu Leu Asp Ser Gly Leu Tyr 
    130                 135                 140                 


Cys Cys Leu Val Val Glu Ile Arg His His His Ser Glu His Arg Val 
145                 150                 155                 160 


His Gly Ala Met Glu Leu Gln Val Gln Thr Gly Lys Asp Ala Pro Ser 
                165                 170                 175     


Asn Cys Val Val Tyr Pro Ser Ser Ser Gln Glu Ser Glu Asn Ile Thr 
            180                 185                 190         


Ala Ala Ala Leu Ala Thr Gly Ala Cys Ile Val Gly Ile Leu Cys Leu 
        195                 200                 205             


Pro Leu Ile Leu Leu Leu Val Tyr Lys Gln Arg Gln Ala Ala Ser Asn 
    210                 215                 220                 


Arg Arg Ala Gln Glu Leu Val Arg Met Asp Ser Asn Ile Gln Gly Ile 
225                 230                 235                 240 


Glu Asn Pro Gly Phe Glu Ala Ser Pro Pro Ala Gln Gly Ile Pro Glu 
                245                 250                 255     


Ala Lys Val Arg His Pro Leu Ser Tyr Val Ala Gln Arg Gln Pro Ser 
            260                 265                 270         


Glu Ser Gly Arg His Leu Leu Ser Glu Pro Ser Thr Pro Leu Ser Pro 
        275                 280                 285             


Pro Gly Pro Gly Asp Val Phe Phe Pro Ser Leu Asp Pro Val Pro Asp 
    290                 295                 300                 


Ser Pro Asn Phe Glu Val Ile 
305                 310     


<210>  232
<211>  1390
<212>  PRT
<213>  Homo sapiens

<400>  232

Met Lys Ala Pro Ala Val Leu Ala Pro Gly Ile Leu Val Leu Leu Phe 
1               5                   10                  15      


Thr Leu Val Gln Arg Ser Asn Gly Glu Cys Lys Glu Ala Leu Ala Lys 
            20                  25                  30          


Ser Glu Met Asn Val Asn Met Lys Tyr Gln Leu Pro Asn Phe Thr Ala 
        35                  40                  45              


Glu Thr Pro Ile Gln Asn Val Ile Leu His Glu His His Ile Phe Leu 
    50                  55                  60                  


Gly Ala Thr Asn Tyr Ile Tyr Val Leu Asn Glu Glu Asp Leu Gln Lys 
65                  70                  75                  80  


Val Ala Glu Tyr Lys Thr Gly Pro Val Leu Glu His Pro Asp Cys Phe 
                85                  90                  95      


Pro Cys Gln Asp Cys Ser Ser Lys Ala Asn Leu Ser Gly Gly Val Trp 
            100                 105                 110         


Lys Asp Asn Ile Asn Met Ala Leu Val Val Asp Thr Tyr Tyr Asp Asp 
        115                 120                 125             


Gln Leu Ile Ser Cys Gly Ser Val Asn Arg Gly Thr Cys Gln Arg His 
    130                 135                 140                 


Val Phe Pro His Asn His Thr Ala Asp Ile Gln Ser Glu Val His Cys 
145                 150                 155                 160 


Ile Phe Ser Pro Gln Ile Glu Glu Pro Ser Gln Cys Pro Asp Cys Val 
                165                 170                 175     


Val Ser Ala Leu Gly Ala Lys Val Leu Ser Ser Val Lys Asp Arg Phe 
            180                 185                 190         


Ile Asn Phe Phe Val Gly Asn Thr Ile Asn Ser Ser Tyr Phe Pro Asp 
        195                 200                 205             


His Pro Leu His Ser Ile Ser Val Arg Arg Leu Lys Glu Thr Lys Asp 
    210                 215                 220                 


Gly Phe Met Phe Leu Thr Asp Gln Ser Tyr Ile Asp Val Leu Pro Glu 
225                 230                 235                 240 


Phe Arg Asp Ser Tyr Pro Ile Lys Tyr Val His Ala Phe Glu Ser Asn 
                245                 250                 255     


Asn Phe Ile Tyr Phe Leu Thr Val Gln Arg Glu Thr Leu Asp Ala Gln 
            260                 265                 270         


Thr Phe His Thr Arg Ile Ile Arg Phe Cys Ser Ile Asn Ser Gly Leu 
        275                 280                 285             


His Ser Tyr Met Glu Met Pro Leu Glu Cys Ile Leu Thr Glu Lys Arg 
    290                 295                 300                 


Lys Lys Arg Ser Thr Lys Lys Glu Val Phe Asn Ile Leu Gln Ala Ala 
305                 310                 315                 320 


Tyr Val Ser Lys Pro Gly Ala Gln Leu Ala Arg Gln Ile Gly Ala Ser 
                325                 330                 335     


Leu Asn Asp Asp Ile Leu Phe Gly Val Phe Ala Gln Ser Lys Pro Asp 
            340                 345                 350         


Ser Ala Glu Pro Met Asp Arg Ser Ala Met Cys Ala Phe Pro Ile Lys 
        355                 360                 365             


Tyr Val Asn Asp Phe Phe Asn Lys Ile Val Asn Lys Asn Asn Val Arg 
    370                 375                 380                 


Cys Leu Gln His Phe Tyr Gly Pro Asn His Glu His Cys Phe Asn Arg 
385                 390                 395                 400 


Thr Leu Leu Arg Asn Ser Ser Gly Cys Glu Ala Arg Arg Asp Glu Tyr 
                405                 410                 415     


Arg Thr Glu Phe Thr Thr Ala Leu Gln Arg Val Asp Leu Phe Met Gly 
            420                 425                 430         


Gln Phe Ser Glu Val Leu Leu Thr Ser Ile Ser Thr Phe Ile Lys Gly 
        435                 440                 445             


Asp Leu Thr Ile Ala Asn Leu Gly Thr Ser Glu Gly Arg Phe Met Gln 
    450                 455                 460                 


Val Val Val Ser Arg Ser Gly Pro Ser Thr Pro His Val Asn Phe Leu 
465                 470                 475                 480 


Leu Asp Ser His Pro Val Ser Pro Glu Val Ile Val Glu His Thr Leu 
                485                 490                 495     


Asn Gln Asn Gly Tyr Thr Leu Val Ile Thr Gly Lys Lys Ile Thr Lys 
            500                 505                 510         


Ile Pro Leu Asn Gly Leu Gly Cys Arg His Phe Gln Ser Cys Ser Gln 
        515                 520                 525             


Cys Leu Ser Ala Pro Pro Phe Val Gln Cys Gly Trp Cys His Asp Lys 
    530                 535                 540                 


Cys Val Arg Ser Glu Glu Cys Leu Ser Gly Thr Trp Thr Gln Gln Ile 
545                 550                 555                 560 


Cys Leu Pro Ala Ile Tyr Lys Val Phe Pro Asn Ser Ala Pro Leu Glu 
                565                 570                 575     


Gly Gly Thr Arg Leu Thr Ile Cys Gly Trp Asp Phe Gly Phe Arg Arg 
            580                 585                 590         


Asn Asn Lys Phe Asp Leu Lys Lys Thr Arg Val Leu Leu Gly Asn Glu 
        595                 600                 605             


Ser Cys Thr Leu Thr Leu Ser Glu Ser Thr Met Asn Thr Leu Lys Cys 
    610                 615                 620                 


Thr Val Gly Pro Ala Met Asn Lys His Phe Asn Met Ser Ile Ile Ile 
625                 630                 635                 640 


Ser Asn Gly His Gly Thr Thr Gln Tyr Ser Thr Phe Ser Tyr Val Asp 
                645                 650                 655     


Pro Val Ile Thr Ser Ile Ser Pro Lys Tyr Gly Pro Met Ala Gly Gly 
            660                 665                 670         


Thr Leu Leu Thr Leu Thr Gly Asn Tyr Leu Asn Ser Gly Asn Ser Arg 
        675                 680                 685             


His Ile Ser Ile Gly Gly Lys Thr Cys Thr Leu Lys Ser Val Ser Asn 
    690                 695                 700                 


Ser Ile Leu Glu Cys Tyr Thr Pro Ala Gln Thr Ile Ser Thr Glu Phe 
705                 710                 715                 720 


Ala Val Lys Leu Lys Ile Asp Leu Ala Asn Arg Glu Thr Ser Ile Phe 
                725                 730                 735     


Ser Tyr Arg Glu Asp Pro Ile Val Tyr Glu Ile His Pro Thr Lys Ser 
            740                 745                 750         


Phe Ile Ser Gly Gly Ser Thr Ile Thr Gly Val Gly Lys Asn Leu Asn 
        755                 760                 765             


Ser Val Ser Val Pro Arg Met Val Ile Asn Val His Glu Ala Gly Arg 
    770                 775                 780                 


Asn Phe Thr Val Ala Cys Gln His Arg Ser Asn Ser Glu Ile Ile Cys 
785                 790                 795                 800 


Cys Thr Thr Pro Ser Leu Gln Gln Leu Asn Leu Gln Leu Pro Leu Lys 
                805                 810                 815     


Thr Lys Ala Phe Phe Met Leu Asp Gly Ile Leu Ser Lys Tyr Phe Asp 
            820                 825                 830         


Leu Ile Tyr Val His Asn Pro Val Phe Lys Pro Phe Glu Lys Pro Val 
        835                 840                 845             


Met Ile Ser Met Gly Asn Glu Asn Val Leu Glu Ile Lys Gly Asn Asp 
    850                 855                 860                 


Ile Asp Pro Glu Ala Val Lys Gly Glu Val Leu Lys Val Gly Asn Lys 
865                 870                 875                 880 


Ser Cys Glu Asn Ile His Leu His Ser Glu Ala Val Leu Cys Thr Val 
                885                 890                 895     


Pro Asn Asp Leu Leu Lys Leu Asn Ser Glu Leu Asn Ile Glu Trp Lys 
            900                 905                 910         


Gln Ala Ile Ser Ser Thr Val Leu Gly Lys Val Ile Val Gln Pro Asp 
        915                 920                 925             


Gln Asn Phe Thr Gly Leu Ile Ala Gly Val Val Ser Ile Ser Thr Ala 
    930                 935                 940                 


Leu Leu Leu Leu Leu Gly Phe Phe Leu Trp Leu Lys Lys Arg Lys Gln 
945                 950                 955                 960 


Ile Lys Asp Leu Gly Ser Glu Leu Val Arg Tyr Asp Ala Arg Val His 
                965                 970                 975     


Thr Pro His Leu Asp Arg Leu Val Ser Ala Arg Ser Val Ser Pro Thr 
            980                 985                 990         


Thr Glu Met Val Ser Asn Glu Ser  Val Asp Tyr Arg Ala  Thr Phe Pro 
        995                 1000                 1005             


Glu Asp  Gln Phe Pro Asn Ser  Ser Gln Asn Gly Ser  Cys Arg Gln 
    1010                 1015                 1020             


Val Gln  Tyr Pro Leu Thr Asp  Met Ser Pro Ile Leu  Thr Ser Gly 
    1025                 1030                 1035             


Asp Ser  Asp Ile Ser Ser Pro  Leu Leu Gln Asn Thr  Val His Ile 
    1040                 1045                 1050             


Asp Leu  Ser Ala Leu Asn Pro  Glu Leu Val Gln Ala  Val Gln His 
    1055                 1060                 1065             


Val Val  Ile Gly Pro Ser Ser  Leu Ile Val His Phe  Asn Glu Val 
    1070                 1075                 1080             


Ile Gly  Arg Gly His Phe Gly  Cys Val Tyr His Gly  Thr Leu Leu 
    1085                 1090                 1095             


Asp Asn  Asp Gly Lys Lys Ile  His Cys Ala Val Lys  Ser Leu Asn 
    1100                 1105                 1110             


Arg Ile  Thr Asp Ile Gly Glu  Val Ser Gln Phe Leu  Thr Glu Gly 
    1115                 1120                 1125             


Ile Ile  Met Lys Asp Phe Ser  His Pro Asn Val Leu  Ser Leu Leu 
    1130                 1135                 1140             


Gly Ile  Cys Leu Arg Ser Glu  Gly Ser Pro Leu Val  Val Leu Pro 
    1145                 1150                 1155             


Tyr Met  Lys His Gly Asp Leu  Arg Asn Phe Ile Arg  Asn Glu Thr 
    1160                 1165                 1170             


His Asn  Pro Thr Val Lys Asp  Leu Ile Gly Phe Gly  Leu Gln Val 
    1175                 1180                 1185             


Ala Lys  Gly Met Lys Tyr Leu  Ala Ser Lys Lys Phe  Val His Arg 
    1190                 1195                 1200             


Asp Leu  Ala Ala Arg Asn Cys  Met Leu Asp Glu Lys  Phe Thr Val 
    1205                 1210                 1215             


Lys Val  Ala Asp Phe Gly Leu  Ala Arg Asp Met Tyr  Asp Lys Glu 
    1220                 1225                 1230             


Tyr Tyr  Ser Val His Asn Lys  Thr Gly Ala Lys Leu  Pro Val Lys 
    1235                 1240                 1245             


Trp Met  Ala Leu Glu Ser Leu  Gln Thr Gln Lys Phe  Thr Thr Lys 
    1250                 1255                 1260             


Ser Asp  Val Trp Ser Phe Gly  Val Leu Leu Trp Glu  Leu Met Thr 
    1265                 1270                 1275             


Arg Gly  Ala Pro Pro Tyr Pro  Asp Val Asn Thr Phe  Asp Ile Thr 
    1280                 1285                 1290             


Val Tyr  Leu Leu Gln Gly Arg  Arg Leu Leu Gln Pro  Glu Tyr Cys 
    1295                 1300                 1305             


Pro Asp  Pro Leu Tyr Glu Val  Met Leu Lys Cys Trp  His Pro Lys 
    1310                 1315                 1320             


Ala Glu  Met Arg Pro Ser Phe  Ser Glu Leu Val Ser  Arg Ile Ser 
    1325                 1330                 1335             


Ala Ile  Phe Ser Thr Phe Ile  Gly Glu His Tyr Val  His Val Asn 
    1340                 1345                 1350             


Ala Thr  Tyr Val Asn Val Lys  Cys Val Ala Pro Tyr  Pro Ser Leu 
    1355                 1360                 1365             


Leu Ser  Ser Glu Asp Asn Ala  Asp Asp Glu Val Asp  Thr Arg Pro 
    1370                 1375                 1380             


Ala Ser  Phe Trp Glu Thr Ser  
    1385                 1390 


<210>  233
<211>  175
<212>  PRT
<213>  Homo sapiens

<400>  233

Met Thr Ala Ile Ser Val Ile Asn Arg Ile Thr Pro Val Leu Gln Asp 
1               5                   10                  15      


Thr Ala Phe Ile Thr Ser Gly Cys Asp His Gln Gln Thr Glu Lys Asn 
            20                  25                  30          


Lys Val Ile Lys Tyr Pro Arg Ser Arg Leu Asp Ala Lys Ile Lys Gln 
        35                  40                  45              


Ser Trp Asn Lys Glu Ser His Phe Gln Gly Asn Tyr Val Lys Ser Val 
    50                  55                  60                  


Val Ala Phe Gly Gln Pro Arg Gly Glu Leu Ser Gln Pro Arg Leu Leu 
65                  70                  75                  80  


Thr Leu Pro His Thr Leu Ser Val Tyr Glu Gly Ser Pro Arg Asn Gln 
                85                  90                  95      


Leu Pro Pro Gly Arg Phe Val Pro Phe Lys Asn Gln Pro Cys Gly Gly 
            100                 105                 110         


Ile Leu Gly Leu Gly Gln Met Thr Val Ser Pro Lys Tyr Leu His Ala 
        115                 120                 125             


Gln Gly Thr Ala Pro Phe Ile Pro Ala Ala Gly Ser Gly Pro Pro Asn 
    130                 135                 140                 


Ser Pro Thr Asn Leu Pro Ser Lys Val Val Asn Asn Lys Asp Phe Leu 
145                 150                 155                 160 


Cys Gly Lys Ser Cys Ser Lys Leu Cys Thr Asp Glu Ser Thr Asn 
                165                 170                 175 


<210>  234
<211>  703
<212>  PRT
<213>  Homo sapiens

<400>  234

Met Glu Arg Ala Ala Pro Ser Arg Arg Val Pro Leu Pro Leu Leu Leu 
1               5                   10                  15      


Leu Gly Gly Leu Ala Leu Leu Ala Ala Gly Val Asp Ala Asp Val Leu 
            20                  25                  30          


Leu Glu Ala Cys Cys Ala Asp Gly His Arg Met Ala Thr His Gln Lys 
        35                  40                  45              


Asp Cys Ser Leu Pro Tyr Ala Thr Glu Ser Lys Glu Cys Arg Met Val 
    50                  55                  60                  


Gln Glu Gln Cys Cys His Ser Gln Leu Glu Glu Leu His Cys Ala Thr 
65                  70                  75                  80  


Gly Ile Ser Leu Ala Asn Glu Gln Asp Arg Cys Ala Thr Pro His Gly 
                85                  90                  95      


Asp Asn Ala Ser Leu Glu Ala Thr Phe Val Lys Arg Cys Cys His Cys 
            100                 105                 110         


Cys Leu Leu Gly Arg Ala Ala Gln Ala Gln Gly Gln Ser Cys Glu Tyr 
        115                 120                 125             


Ser Leu Met Val Gly Tyr Gln Cys Gly Gln Val Phe Gln Ala Cys Cys 
    130                 135                 140                 


Val Lys Ser Gln Glu Thr Gly Asp Leu Asp Val Gly Gly Leu Gln Glu 
145                 150                 155                 160 


Thr Asp Lys Ile Ile Glu Val Glu Glu Glu Gln Glu Asp Pro Tyr Leu 
                165                 170                 175     


Asn Asp Arg Cys Arg Gly Gly Gly Pro Cys Lys Gln Gln Cys Arg Asp 
            180                 185                 190         


Thr Gly Asp Glu Val Val Cys Ser Cys Phe Val Gly Tyr Gln Leu Leu 
        195                 200                 205             


Ser Asp Gly Val Ser Cys Glu Asp Val Asn Glu Cys Ile Thr Gly Ser 
    210                 215                 220                 


His Ser Cys Arg Leu Gly Glu Ser Cys Ile Asn Thr Val Gly Ser Phe 
225                 230                 235                 240 


Arg Cys Gln Arg Asp Ser Ser Cys Gly Thr Gly Tyr Glu Leu Thr Glu 
                245                 250                 255     


Asp Asn Ser Cys Lys Asp Ile Asp Glu Cys Glu Ser Gly Ile His Asn 
            260                 265                 270         


Cys Leu Pro Asp Phe Ile Cys Gln Asn Thr Leu Gly Ser Phe Arg Cys 
        275                 280                 285             


Arg Pro Lys Leu Gln Cys Lys Ser Gly Phe Ile Gln Asp Ala Leu Gly 
    290                 295                 300                 


Asn Cys Ile Asp Ile Asn Glu Cys Leu Ser Ile Ser Ala Pro Cys Pro 
305                 310                 315                 320 


Ile Gly His Thr Cys Ile Asn Thr Glu Gly Ser Tyr Thr Cys Gln Lys 
                325                 330                 335     


Asn Val Pro Asn Cys Gly Arg Gly Tyr His Leu Asn Glu Glu Gly Thr 
            340                 345                 350         


Arg Cys Val Asp Val Asp Glu Cys Ala Pro Pro Ala Glu Pro Cys Gly 
        355                 360                 365             


Lys Gly His Arg Cys Val Asn Ser Pro Gly Ser Phe Arg Cys Glu Cys 
    370                 375                 380                 


Lys Thr Gly Tyr Tyr Phe Asp Gly Ile Ser Arg Met Cys Val Asp Val 
385                 390                 395                 400 


Asn Glu Cys Gln Arg Tyr Pro Gly Arg Leu Cys Gly His Lys Cys Glu 
                405                 410                 415     


Asn Thr Leu Gly Ser Tyr Leu Cys Ser Cys Ser Val Gly Phe Arg Leu 
            420                 425                 430         


Ser Val Asp Gly Arg Ser Cys Glu Asp Ile Asn Glu Cys Ser Ser Ser 
        435                 440                 445             


Pro Cys Ser Gln Glu Cys Ala Asn Val Tyr Gly Ser Tyr Gln Cys Tyr 
    450                 455                 460                 


Cys Arg Arg Gly Tyr Gln Leu Ser Asp Val Asp Gly Val Thr Cys Glu 
465                 470                 475                 480 


Asp Ile Asp Glu Cys Ala Leu Pro Thr Gly Gly His Ile Cys Ser Tyr 
                485                 490                 495     


Arg Cys Ile Asn Ile Pro Gly Ser Phe Gln Cys Ser Cys Pro Ser Ser 
            500                 505                 510         


Gly Tyr Arg Leu Ala Pro Asn Gly Arg Asn Cys Gln Asp Ile Asp Glu 
        515                 520                 525             


Cys Val Thr Gly Ile His Asn Cys Ser Ile Asn Glu Thr Cys Phe Asn 
    530                 535                 540                 


Ile Gln Gly Gly Phe Arg Cys Leu Ala Phe Glu Cys Pro Glu Asn Tyr 
545                 550                 555                 560 


Arg Arg Ser Ala Ala Thr Leu Gln Gln Glu Lys Thr Asp Thr Val Arg 
                565                 570                 575     


Cys Ile Lys Ser Cys Arg Pro Asn Asp Val Thr Cys Val Phe Asp Pro 
            580                 585                 590         


Val His Thr Ile Ser His Thr Val Ile Ser Leu Pro Thr Phe Arg Glu 
        595                 600                 605             


Phe Thr Arg Pro Glu Glu Ile Ile Phe Leu Arg Ala Ile Thr Pro Pro 
    610                 615                 620                 


His Pro Ala Ser Gln Ala Asn Ile Ile Phe Asp Ile Thr Glu Gly Asn 
625                 630                 635                 640 


Leu Arg Asp Ser Phe Asp Ile Ile Lys Arg Tyr Met Asp Gly Met Thr 
                645                 650                 655     


Val Gly Val Val Arg Gln Val Arg Pro Ile Val Gly Pro Phe His Ala 
            660                 665                 670         


Val Leu Lys Leu Glu Met Asn Tyr Val Val Gly Gly Val Val Ser His 
        675                 680                 685             


Arg Asn Val Val Asn Val His Ile Phe Val Ser Glu Tyr Trp Phe 
    690                 695                 700             


<210>  235
<211>  271
<212>  PRT
<213>  Homo sapiens

<400>  235

Met Glu Ala Leu Pro Leu Leu Ala Ala Thr Thr Pro Asp His Gly Arg 
1               5                   10                  15      


His Arg Arg Leu Leu Leu Leu Pro Leu Leu Leu Phe Leu Leu Pro Ala 
            20                  25                  30          


Gly Ala Val Gln Gly Trp Glu Thr Glu Glu Arg Pro Arg Thr Arg Glu 
        35                  40                  45              


Glu Glu Cys His Phe Tyr Ala Gly Gly Gln Val Tyr Pro Gly Glu Ala 
    50                  55                  60                  


Ser Arg Val Ser Val Ala Asp His Ser Leu His Leu Ser Lys Ala Lys 
65                  70                  75                  80  


Ile Ser Lys Pro Ala Pro Tyr Trp Glu Gly Thr Ala Val Ile Asp Gly 
                85                  90                  95      


Glu Phe Lys Glu Leu Lys Leu Thr Asp Tyr Arg Gly Lys Tyr Leu Val 
            100                 105                 110         


Phe Phe Phe Tyr Pro Leu Asp Phe Thr Phe Val Cys Pro Thr Glu Ile 
        115                 120                 125             


Ile Ala Phe Gly Asp Arg Leu Glu Glu Phe Arg Ser Ile Asn Thr Glu 
    130                 135                 140                 


Val Val Ala Cys Ser Val Asp Ser Gln Phe Thr His Leu Ala Trp Ile 
145                 150                 155                 160 


Asn Thr Pro Arg Arg Gln Gly Gly Leu Gly Pro Ile Arg Ile Pro Leu 
                165                 170                 175     


Leu Ser Asp Leu Thr His Gln Ile Ser Lys Asp Tyr Gly Val Tyr Leu 
            180                 185                 190         


Glu Asp Ser Gly His Thr Leu Arg Gly Leu Phe Ile Ile Asp Asp Lys 
        195                 200                 205             


Gly Ile Leu Arg Gln Ile Thr Leu Asn Asp Leu Pro Val Gly Arg Ser 
    210                 215                 220                 


Val Asp Glu Thr Leu Arg Leu Val Gln Ala Phe Gln Tyr Thr Asp Lys 
225                 230                 235                 240 


His Gly Glu Val Cys Pro Ala Gly Trp Lys Pro Gly Ser Glu Thr Ile 
                245                 250                 255     


Ile Pro Asp Pro Ala Gly Lys Leu Lys Tyr Phe Asp Lys Leu Asn 
            260                 265                 270     


<210>  236
<211>  321
<212>  PRT
<213>  Homo sapiens

<400>  236

Met Ser Leu Gln Lys Leu Met Glu Pro Glu Ala Gly Thr Asn Arg Thr 
1               5                   10                  15      


Ala Val Ala Glu Phe Ile Leu Leu Gly Leu Val Gln Thr Glu Glu Met 
            20                  25                  30          


Gln Pro Val Val Phe Val Leu Leu Leu Phe Ala Tyr Leu Val Thr Thr 
        35                  40                  45              


Gly Gly Asn Leu Ser Ile Leu Ala Ala Val Leu Val Glu Pro Lys Leu 
    50                  55                  60                  


His Ala Pro Met Tyr Phe Phe Leu Gly Asn Leu Ser Val Leu Asp Val 
65                  70                  75                  80  


Gly Cys Ile Thr Val Thr Val Pro Ala Met Leu Gly Arg Leu Leu Ser 
                85                  90                  95      


His Lys Ser Thr Ile Ser Tyr Asp Ala Cys Leu Ser Gln Leu Phe Phe 
            100                 105                 110         


Phe His Leu Leu Ala Gly Met Asp Cys Phe Leu Leu Thr Ala Met Ala 
        115                 120                 125             


Tyr Asp Arg Leu Leu Ala Ile Cys Gln Pro Leu Thr Tyr Ser Thr Arg 
    130                 135                 140                 


Met Ser Gln Thr Val Gln Arg Met Leu Val Ala Ala Ser Trp Ala Cys 
145                 150                 155                 160 


Ala Phe Thr Asn Ala Leu Thr His Thr Val Ala Met Ser Thr Leu Asn 
                165                 170                 175     


Phe Cys Gly Pro Asn Glu Val Asn His Phe Tyr Cys Asp Leu Pro Gln 
            180                 185                 190         


Leu Phe Gln Leu Ser Cys Ser Ser Thr Gln Leu Asn Glu Leu Leu Leu 
        195                 200                 205             


Phe Val Ala Ala Ala Phe Met Ala Val Ala Pro Leu Val Phe Ile Ser 
    210                 215                 220                 


Val Ser Tyr Ala His Val Val Ala Ala Val Leu Gln Ile Arg Ser Ala 
225                 230                 235                 240 


Glu Gly Arg Lys Lys Ala Phe Ser Thr Cys Gly Ser His Leu Thr Val 
                245                 250                 255     


Val Gly Ile Phe Tyr Gly Thr Gly Val Phe Ser Tyr Met Arg Leu Gly 
            260                 265                 270         


Ser Val Glu Ser Ser Asp Lys Asp Lys Gly Val Gly Val Phe Met Thr 
        275                 280                 285             


Val Ile Asn Pro Met Leu Asn Pro Leu Ile Tyr Ser Leu Arg Asn Thr 
    290                 295                 300                 


Asp Val Gln Gly Ala Leu Cys Gln Leu Leu Val Gly Lys Arg Ser Leu 
305                 310                 315                 320 


Thr 
    


<210>  237
<211>  269
<212>  PRT
<213>  Homo sapiens

<400>  237

Met Ser Ser Tyr Phe Val Asn Ser Phe Ser Gly Arg Tyr Pro Asn Gly 
1               5                   10                  15      


Pro Asp Tyr Gln Leu Leu Asn Tyr Gly Ser Gly Ser Ser Leu Ser Gly 
            20                  25                  30          


Ser Tyr Arg Asp Pro Ala Ala Met His Thr Gly Ser Tyr Gly Tyr Asn 
        35                  40                  45              


Tyr Asn Gly Met Asp Leu Ser Val Asn Arg Ser Ser Ala Ser Ser Ser 
    50                  55                  60                  


His Phe Gly Ala Val Gly Glu Ser Ser Arg Ala Phe Pro Ala Pro Ala 
65                  70                  75                  80  


Gln Glu Pro Arg Phe Arg Gln Ala Ala Ser Ser Cys Ser Leu Ser Ser 
                85                  90                  95      


Pro Glu Ser Leu Pro Cys Thr Asn Gly Asp Ser His Gly Ala Lys Pro 
            100                 105                 110         


Ser Ala Ser Ser Pro Ser Asp Gln Ala Thr Ser Ala Ser Ser Ser Ala 
        115                 120                 125             


Asn Phe Thr Glu Ile Asp Glu Ala Ser Ala Ser Ser Glu Pro Glu Glu 
    130                 135                 140                 


Ala Ala Ser Gln Leu Ser Ser Pro Ser Leu Ala Arg Ala Gln Pro Glu 
145                 150                 155                 160 


Pro Met Ala Thr Ser Thr Ala Ala Pro Glu Gly Gln Thr Pro Gln Ile 
                165                 170                 175     


Phe Pro Trp Met Arg Lys Leu His Ile Ser His Asp Met Thr Gly Pro 
            180                 185                 190         


Asp Gly Lys Arg Ala Arg Thr Ala Tyr Thr Arg Tyr Gln Thr Leu Glu 
        195                 200                 205             


Leu Glu Lys Glu Phe His Phe Asn Arg Tyr Leu Thr Arg Arg Arg Arg 
    210                 215                 220                 


Ile Glu Ile Ala His Ala Leu Cys Leu Ser Glu Arg Gln Ile Lys Ile 
225                 230                 235                 240 


Trp Phe Gln Asn Arg Arg Met Lys Trp Lys Lys Asp Asn Lys Leu Lys 
                245                 250                 255     


Ser Met Ser Leu Ala Thr Ala Gly Ser Ala Phe Gln Pro 
            260                 265                 


<210>  238
<211>  189
<212>  PRT
<213>  Homo sapiens

<400>  238

Met Thr Glu Tyr Lys Leu Val Val Val Gly Ala Gly Gly Val Gly Lys 
1               5                   10                  15      


Ser Ala Leu Thr Ile Gln Leu Ile Gln Asn His Phe Val Asp Glu Tyr 
            20                  25                  30          


Asp Pro Thr Ile Glu Asp Ser Tyr Arg Lys Gln Val Val Ile Asp Gly 
        35                  40                  45              


Glu Thr Cys Leu Leu Asp Ile Leu Asp Thr Ala Gly Gln Glu Glu Tyr 
    50                  55                  60                  


Ser Ala Met Arg Asp Gln Tyr Met Arg Thr Gly Glu Gly Phe Leu Cys 
65                  70                  75                  80  


Val Phe Ala Ile Asn Asn Thr Lys Ser Phe Glu Asp Ile His His Tyr 
                85                  90                  95      


Arg Glu Gln Ile Lys Arg Val Lys Asp Ser Glu Asp Val Pro Met Val 
            100                 105                 110         


Leu Val Gly Asn Lys Cys Asp Leu Pro Ser Arg Thr Val Asp Thr Lys 
        115                 120                 125             


Gln Ala Gln Asp Leu Ala Arg Ser Tyr Gly Ile Pro Phe Ile Glu Thr 
    130                 135                 140                 


Ser Ala Lys Thr Arg Gln Arg Val Glu Asp Ala Phe Tyr Thr Leu Val 
145                 150                 155                 160 


Arg Glu Ile Arg Gln Tyr Arg Leu Lys Lys Ile Ser Lys Glu Glu Lys 
                165                 170                 175     


Thr Pro Gly Cys Val Lys Ile Lys Lys Cys Ile Ile Met 
            180                 185                 


<210>  239
<211>  420
<212>  PRT
<213>  Homo sapiens

<400>  239

Met Leu Ser Ser Phe Pro Val Val Leu Leu Glu Thr Met Ser His Tyr 
1               5                   10                  15      


Thr Asp Glu Pro Arg Phe Thr Ile Glu Gln Ile Asp Leu Leu Gln Arg 
            20                  25                  30          


Leu Arg Arg Thr Gly Met Thr Lys His Glu Ile Leu His Ala Leu Glu 
        35                  40                  45              


Thr Leu Asp Arg Leu Asp Gln Glu His Ser Asp Lys Phe Gly Arg Arg 
    50                  55                  60                  


Ser Ser Tyr Gly Gly Ser Ser Tyr Gly Asn Ser Thr Asn Asn Val Pro 
65                  70                  75                  80  


Ala Ser Ser Ser Thr Ala Thr Ala Ser Thr Gln Thr Gln His Ser Gly 
                85                  90                  95      


Met Ser Pro Ser Pro Ser Asn Ser Tyr Asp Thr Ser Pro Gln Pro Cys 
            100                 105                 110         


Thr Thr Asn Gln Asn Gly Arg Glu Asn Asn Glu Arg Leu Ser Thr Ser 
        115                 120                 125             


Asn Gly Lys Met Ser Pro Thr Arg Tyr His Ala Asn Ser Met Gly Gln 
    130                 135                 140                 


Arg Ser Tyr Ser Phe Glu Ala Ser Glu Glu Asp Leu Asp Val Asp Asp 
145                 150                 155                 160 


Lys Val Glu Glu Leu Met Arg Arg Asp Ser Ser Val Ile Lys Glu Glu 
                165                 170                 175     


Ile Lys Ala Phe Leu Ala Asn Arg Arg Ile Ser Gln Ala Val Val Ala 
            180                 185                 190         


Gln Val Thr Gly Ile Ser Gln Ser Arg Ile Ser His Trp Leu Leu Gln 
        195                 200                 205             


Gln Gly Ser Asp Leu Ser Glu Gln Lys Lys Arg Ala Phe Tyr Arg Trp 
    210                 215                 220                 


Tyr Gln Leu Glu Lys Thr Asn Pro Gly Ala Thr Leu Ser Met Arg Pro 
225                 230                 235                 240 


Ala Pro Ile Pro Ile Glu Asp Pro Glu Trp Arg Gln Thr Pro Pro Pro 
                245                 250                 255     


Val Ser Ala Thr Ser Gly Thr Phe Arg Leu Arg Arg Gly Ser Arg Phe 
            260                 265                 270         


Thr Trp Arg Lys Glu Cys Leu Ala Val Met Glu Ser Tyr Phe Asn Glu 
        275                 280                 285             


Asn Gln Tyr Pro Asp Glu Ala Lys Arg Glu Glu Ile Ala Asn Ala Cys 
    290                 295                 300                 


Asn Ala Val Ile Gln Lys Pro Gly Lys Lys Leu Ser Asp Leu Glu Arg 
305                 310                 315                 320 


Val Thr Ser Leu Lys Val Tyr Asn Trp Phe Ala Asn Arg Arg Lys Glu 
                325                 330                 335     


Ile Lys Arg Arg Ala Asn Ile Glu Ala Ala Ile Leu Glu Ser His Gly 
            340                 345                 350         


Ile Asp Val Gln Ser Pro Gly Gly His Ser Asn Ser Asp Asp Val Asp 
        355                 360                 365             


Gly Asn Asp Tyr Ser Glu Gln Asp Asp Ser Thr Ser His Ser Asp His 
    370                 375                 380                 


Gln Asp Pro Ile Ser Leu Ala Val Glu Met Ala Ala Val Asn His Thr 
385                 390                 395                 400 


Ile Leu Ala Leu Ala Arg Gln Gly Ala Asn Glu Ile Lys Thr Glu Ala 
                405                 410                 415     


Leu Asp Asp Asp 
            420 


<210>  240
<211>  161
<212>  PRT
<213>  Homo sapiens

<400>  240

Met Ala Gly Arg Lys Leu Ala Leu Lys Thr Ile Asp Trp Val Ala Phe 
1               5                   10                  15      


Ala Glu Ile Ile Pro Gln Asn Gln Lys Ala Ile Ala Ser Ser Leu Lys 
            20                  25                  30          


Ser Trp Asn Glu Thr Leu Thr Ser Arg Leu Ala Ala Leu Pro Glu Asn 
        35                  40                  45              


Pro Pro Ala Ile Asp Trp Ala Tyr Tyr Lys Ala Asn Val Ala Lys Ala 
    50                  55                  60                  


Gly Leu Val Asp Asp Phe Glu Lys Lys Phe Asn Ala Leu Lys Val Pro 
65                  70                  75                  80  


Val Pro Glu Asp Lys Tyr Thr Ala Gln Val Asp Ala Glu Glu Lys Glu 
                85                  90                  95      


Asp Val Lys Ser Cys Ala Glu Trp Val Ser Leu Ser Lys Ala Arg Ile 
            100                 105                 110         


Val Glu Tyr Glu Lys Glu Met Glu Lys Met Lys Asn Leu Ile Pro Phe 
        115                 120                 125             


Asp Gln Met Thr Ile Glu Asp Leu Asn Glu Ala Phe Pro Glu Thr Lys 
    130                 135                 140                 


Leu Asp Lys Lys Lys Tyr Pro Tyr Trp Pro His Gln Pro Ile Glu Asn 
145                 150                 155                 160 


Leu 
    


<210>  241
<211>  514
<212>  PRT
<213>  Homo sapiens

<400>  241

Met Ala Asp Tyr Leu Ile Ser Gly Gly Thr Gly Tyr Val Pro Glu Asp 
1               5                   10                  15      


Gly Leu Thr Ala Gln Gln Leu Phe Ala Ser Ala Asp Gly Leu Thr Tyr 
            20                  25                  30          


Asn Asp Phe Leu Ile Leu Pro Gly Phe Ile Asp Phe Ile Ala Asp Glu 
        35                  40                  45              


Val Asp Leu Thr Ser Ala Leu Thr Arg Lys Ile Thr Leu Lys Thr Pro 
    50                  55                  60                  


Leu Ile Ser Ser Pro Met Asp Thr Val Thr Glu Ala Asp Met Ala Ile 
65                  70                  75                  80  


Ala Met Ala Leu Met Gly Gly Ile Gly Phe Ile His His Asn Cys Thr 
                85                  90                  95      


Pro Glu Phe Gln Ala Asn Glu Val Arg Lys Val Lys Lys Phe Glu Gln 
            100                 105                 110         


Gly Phe Ile Thr Asp Pro Val Val Leu Ser Pro Ser His Thr Val Gly 
        115                 120                 125             


Asp Val Leu Glu Ala Lys Met Arg His Gly Phe Ser Gly Ile Pro Ile 
    130                 135                 140                 


Thr Glu Thr Gly Thr Met Gly Ser Lys Leu Val Gly Ile Val Thr Ser 
145                 150                 155                 160 


Arg Asp Ile Asp Phe Leu Ala Glu Lys Asp His Thr Thr Leu Leu Ser 
                165                 170                 175     


Glu Val Met Thr Pro Arg Ile Glu Leu Val Val Ala Pro Ala Gly Val 
            180                 185                 190         


Thr Leu Lys Glu Ala Asn Glu Ile Leu Gln Arg Ser Lys Lys Gly Lys 
        195                 200                 205             


Leu Pro Ile Val Asn Asp Cys Asp Glu Leu Val Ala Ile Ile Ala Arg 
    210                 215                 220                 


Thr Asp Leu Lys Lys Asn Arg Asp Tyr Pro Leu Ala Ser Lys Asp Ser 
225                 230                 235                 240 


Gln Lys Gln Leu Leu Cys Gly Ala Ala Val Gly Thr Arg Glu Asp Asp 
                245                 250                 255     


Lys Tyr Arg Leu Asp Leu Leu Thr Gln Ala Gly Val Asp Val Ile Val 
            260                 265                 270         


Leu Asp Ser Ser Gln Gly Asn Ser Val Tyr Gln Ile Ala Met Val His 
        275                 280                 285             


Tyr Ile Lys Gln Lys Tyr Pro His Leu Gln Val Ile Gly Gly Asn Val 
    290                 295                 300                 


Val Thr Ala Ala Gln Ala Lys Asn Leu Ile Asp Ala Gly Val Asp Gly 
305                 310                 315                 320 


Leu Arg Val Gly Met Gly Cys Gly Ser Ile Cys Ile Thr Gln Glu Val 
                325                 330                 335     


Met Ala Cys Gly Arg Pro Gln Gly Thr Ala Val Tyr Lys Val Ala Glu 
            340                 345                 350         


Tyr Ala Arg Arg Phe Gly Val Pro Ile Ile Ala Asp Gly Gly Ile Gln 
        355                 360                 365             


Thr Val Gly His Val Val Lys Ala Leu Ala Leu Gly Ala Ser Thr Val 
    370                 375                 380                 


Met Met Gly Ser Leu Leu Ala Ala Thr Thr Glu Ala Pro Gly Glu Tyr 
385                 390                 395                 400 


Phe Phe Ser Asp Gly Val Arg Leu Lys Lys Tyr Arg Gly Met Gly Ser 
                405                 410                 415     


Leu Asp Ala Met Glu Lys Ser Ser Ser Ser Gln Lys Arg Tyr Phe Ser 
            420                 425                 430         


Glu Gly Asp Lys Val Lys Ile Ala Gln Gly Val Ser Gly Ser Ile Gln 
        435                 440                 445             


Asp Lys Gly Ser Ile Gln Lys Phe Val Pro Tyr Leu Ile Ala Gly Ile 
    450                 455                 460                 


Gln His Gly Cys Gln Asp Ile Gly Ala Arg Ser Leu Ser Val Leu Arg 
465                 470                 475                 480 


Ser Met Met Tyr Ser Gly Glu Leu Lys Phe Glu Lys Arg Thr Met Ser 
                485                 490                 495     


Ala Gln Ile Glu Gly Gly Val His Gly Leu His Ser Tyr Glu Lys Arg 
            500                 505                 510         


Leu Tyr 
        


<210>  242
<211>  261
<212>  PRT
<213>  Homo sapiens

<400>  242

Met Trp Val Pro Val Val Phe Leu Thr Leu Ser Val Thr Trp Ile Gly 
1               5                   10                  15      


Ala Ala Pro Leu Ile Leu Ser Arg Ile Val Gly Gly Trp Glu Cys Glu 
            20                  25                  30          


Lys His Ser Gln Pro Trp Gln Val Leu Val Ala Ser Arg Gly Arg Ala 
        35                  40                  45              


Val Cys Gly Gly Val Leu Val His Pro Gln Trp Val Leu Thr Ala Ala 
    50                  55                  60                  


His Cys Ile Arg Asn Lys Ser Val Ile Leu Leu Gly Arg His Ser Leu 
65                  70                  75                  80  


Phe His Pro Glu Asp Thr Gly Gln Val Phe Gln Val Ser His Ser Phe 
                85                  90                  95      


Pro His Pro Leu Tyr Asp Met Ser Leu Leu Lys Asn Arg Phe Leu Arg 
            100                 105                 110         


Pro Gly Asp Asp Ser Ser His Asp Leu Met Leu Leu Arg Leu Ser Glu 
        115                 120                 125             


Pro Ala Glu Leu Thr Asp Ala Val Lys Val Met Asp Leu Pro Thr Gln 
    130                 135                 140                 


Glu Pro Ala Leu Gly Thr Thr Cys Tyr Ala Ser Gly Trp Gly Ser Ile 
145                 150                 155                 160 


Glu Pro Glu Glu Phe Leu Thr Pro Lys Lys Leu Gln Cys Val Asp Leu 
                165                 170                 175     


His Val Ile Ser Asn Asp Val Cys Ala Gln Val His Pro Gln Lys Val 
            180                 185                 190         


Thr Lys Phe Met Leu Cys Ala Gly Arg Trp Thr Gly Gly Lys Ser Thr 
        195                 200                 205             


Cys Ser Gly Asp Ser Gly Gly Pro Leu Val Cys Asn Gly Val Leu Gln 
    210                 215                 220                 


Gly Ile Thr Ser Trp Gly Ser Glu Pro Cys Ala Leu Pro Glu Arg Pro 
225                 230                 235                 240 


Ser Leu Tyr Thr Lys Val Val His Tyr Arg Lys Trp Ile Lys Asp Thr 
                245                 250                 255     


Ile Val Ala Asn Pro 
            260     


<210>  243
<211>  562
<212>  PRT
<213>  Homo sapiens

<400>  243

Met Ala Leu Ser Lys Ser Met His Ala Arg Asn Arg Tyr Lys Asp Lys 
1               5                   10                  15      


Pro Pro Asp Phe Ala Tyr Leu Ala Ser Lys Tyr Pro Asp Phe Lys Gln 
            20                  25                  30          


His Val Gln Ile Asn Leu Asn Gly Arg Val Ser Leu Asn Phe Lys Asp 
        35                  40                  45              


Pro Glu Ala Val Arg Ala Leu Thr Cys Thr Leu Leu Arg Glu Asp Phe 
    50                  55                  60                  


Gly Leu Ser Ile Asp Ile Pro Leu Glu Arg Leu Ile Pro Thr Val Pro 
65                  70                  75                  80  


Leu Arg Leu Asn Tyr Ile His Trp Val Glu Asp Leu Ile Gly His Gln 
                85                  90                  95      


Asp Ser Asp Lys Ser Thr Leu Arg Arg Gly Ile Asp Ile Gly Thr Gly 
            100                 105                 110         


Ala Ser Cys Ile Tyr Pro Leu Leu Gly Ala Thr Leu Asn Gly Trp Tyr 
        115                 120                 125             


Phe Leu Ala Thr Glu Val Asp Asp Met Cys Phe Asn Tyr Ala Lys Lys 
    130                 135                 140                 


Asn Val Glu Gln Asn Asn Leu Ser Asp Leu Ile Lys Val Val Lys Val 
145                 150                 155                 160 


Pro Gln Lys Thr Leu Leu Met Asp Ala Leu Lys Glu Glu Ser Glu Ile 
                165                 170                 175     


Ile Tyr Asp Phe Cys Met Cys Asn Pro Pro Phe Phe Ala Asn Gln Leu 
            180                 185                 190         


Glu Ala Lys Gly Val Asn Ser Arg Asn Pro Arg Arg Pro Pro Pro Ser 
        195                 200                 205             


Ser Val Asn Thr Gly Gly Ile Thr Glu Ile Met Ala Glu Gly Gly Glu 
    210                 215                 220                 


Leu Glu Phe Val Lys Arg Ile Ile His Asp Ser Leu Gln Leu Lys Lys 
225                 230                 235                 240 


Arg Leu Arg Trp Tyr Ser Cys Met Leu Gly Lys Lys Cys Ser Leu Ala 
                245                 250                 255     


Pro Leu Lys Glu Glu Leu Arg Ile Gln Gly Val Pro Lys Val Thr Tyr 
            260                 265                 270         


Thr Glu Phe Cys Gln Gly Arg Thr Met Arg Trp Ala Leu Ala Trp Ser 
        275                 280                 285             


Phe Tyr Asp Asp Val Thr Val Pro Ser Pro Pro Ser Lys Arg Arg Lys 
    290                 295                 300                 


Leu Glu Lys Pro Arg Lys Pro Ile Thr Phe Val Val Leu Ala Ser Val 
305                 310                 315                 320 


Met Lys Glu Leu Ser Leu Lys Ala Ser Pro Leu Arg Ser Glu Thr Ala 
                325                 330                 335     


Glu Gly Ile Val Val Val Thr Thr Trp Ile Glu Lys Ile Leu Thr Asp 
            340                 345                 350         


Leu Lys Val Gln His Lys Arg Val Pro Cys Gly Lys Glu Glu Val Ser 
        355                 360                 365             


Leu Phe Leu Thr Ala Ile Glu Asn Ser Trp Ile His Leu Arg Arg Lys 
    370                 375                 380                 


Lys Arg Glu Arg Val Arg Gln Leu Arg Glu Val Pro Arg Ala Pro Glu 
385                 390                 395                 400 


Asp Val Ile Gln Ala Leu Glu Glu Lys Lys Pro Thr Pro Lys Glu Ser 
                405                 410                 415     


Gly Asn Ser Gln Glu Leu Ala Arg Gly Pro Gln Glu Arg Thr Pro Cys 
            420                 425                 430         


Gly Pro Ala Leu Arg Glu Gly Glu Ala Ala Ala Val Glu Gly Pro Cys 
        435                 440                 445             


Pro Ser Gln Glu Ser Leu Ser Gln Glu Glu Asn Pro Glu Pro Thr Glu 
    450                 455                 460                 


Asp Glu Arg Ser Glu Glu Lys Gly Gly Val Glu Val Leu Glu Asn Cys 
465                 470                 475                 480 


Gln Gly Ser Ser Asn Gly Ala Gln Asp Gln Glu Ala Ser Glu Gln Phe 
                485                 490                 495     


Gly Ser Pro Val Ala Glu Arg Gly Lys Arg Leu Pro Gly Val Ala Gly 
            500                 505                 510         


Gln Tyr Leu Phe Lys Cys Leu Ile Asn Val Lys Lys Glu Val Asp Asp 
        515                 520                 525             


Ala Leu Val Glu Met His Trp Val Glu Gly Gln Asn Arg Asp Leu Met 
    530                 535                 540                 


Asn Gln Leu Cys Thr Tyr Ile Arg Asn Gln Ile Phe Arg Leu Val Ala 
545                 550                 555                 560 


Val Asn 
        


<210>  244
<211>  411
<212>  PRT
<213>  Homo sapiens

<400>  244

Met Asp Ala Ala Leu Leu His Ser Leu Leu Glu Ala Asn Cys Ser Leu 
1               5                   10                  15      


Ala Leu Ala Glu Glu Leu Leu Leu Asp Gly Trp Gly Pro Pro Leu Asp 
            20                  25                  30          


Pro Glu Gly Pro Tyr Ser Tyr Cys Asn Thr Thr Leu Asp Gln Ile Gly 
        35                  40                  45              


Thr Cys Trp Pro Arg Ser Ala Ala Gly Ala Leu Val Glu Arg Pro Cys 
    50                  55                  60                  


Pro Glu Tyr Phe Asn Gly Val Lys Tyr Asn Thr Thr Arg Asn Ala Tyr 
65                  70                  75                  80  


Arg Glu Cys Leu Glu Asn Gly Thr Trp Ala Ser Lys Ile Asn Tyr Ser 
                85                  90                  95      


Gln Cys Glu Pro Ile Leu Asp Asp Lys Gln Arg Lys Tyr Asp Leu His 
            100                 105                 110         


Tyr Arg Ile Ala Leu Val Val Asn Tyr Leu Gly His Cys Val Ser Val 
        115                 120                 125             


Ala Ala Leu Val Ala Ala Phe Leu Leu Phe Leu Ala Leu Arg Ser Ile 
    130                 135                 140                 


Arg Cys Leu Arg Asn Val Ile His Trp Asn Leu Ile Thr Thr Phe Ile 
145                 150                 155                 160 


Leu Arg Asn Val Met Trp Phe Leu Leu Gln Leu Val Asp His Glu Val 
                165                 170                 175     


His Glu Ser Asn Glu Val Trp Cys Arg Cys Ile Thr Thr Ile Phe Asn 
            180                 185                 190         


Tyr Phe Val Val Thr Asn Phe Phe Trp Met Phe Val Glu Gly Cys Tyr 
        195                 200                 205             


Leu His Thr Ala Ile Val Met Thr Tyr Ser Thr Glu Arg Leu Arg Lys 
    210                 215                 220                 


Cys Leu Phe Leu Phe Ile Gly Trp Cys Ile Pro Phe Pro Ile Ile Val 
225                 230                 235                 240 


Ala Trp Ala Ile Gly Lys Leu Tyr Tyr Glu Asn Glu Gln Cys Trp Phe 
                245                 250                 255     


Gly Lys Glu Pro Gly Asp Leu Val Asp Tyr Ile Tyr Gln Gly Pro Ile 
            260                 265                 270         


Ile Leu Val Leu Leu Ile Asn Phe Val Phe Leu Phe Asn Ile Val Arg 
        275                 280                 285             


Ile Leu Met Thr Lys Leu Arg Ala Ser Thr Thr Ser Glu Thr Ile Gln 
    290                 295                 300                 


Tyr Arg Lys Ala Val Lys Ala Thr Leu Val Leu Leu Pro Leu Leu Gly 
305                 310                 315                 320 


Ile Thr Tyr Met Leu Phe Phe Val Asn Pro Gly Glu Asp Asp Leu Ser 
                325                 330                 335     


Gln Ile Met Phe Ile Tyr Phe Asn Ser Phe Leu Gln Ser Phe Gln Gly 
            340                 345                 350         


Phe Phe Val Ser Val Phe Tyr Cys Phe Phe Asn Gly Glu Val Arg Ser 
        355                 360                 365             


Ala Val Arg Lys Arg Trp His Arg Trp Gln Asp His His Ser Leu Arg 
    370                 375                 380                 


Val Pro Met Ala Arg Ala Met Ser Ile Pro Thr Ser Pro Thr Arg Ile 
385                 390                 395                 400 


Ser Phe His Ser Ile Lys Gln Thr Ala Ala Val 
                405                 410     


<210>  245
<211>  300
<212>  PRT
<213>  Homo sapiens

<400>  245

Met Glu Glu Glu Ala Ser Ser Pro Gly Leu Gly Cys Ser Lys Pro His 
1               5                   10                  15      


Leu Glu Lys Leu Thr Leu Gly Ile Thr Arg Ile Leu Glu Ser Ser Pro 
            20                  25                  30          


Gly Val Thr Glu Val Thr Ile Ile Glu Lys Pro Pro Ala Glu Arg His 
        35                  40                  45              


Met Ile Ser Ser Trp Glu Gln Lys Asn Asn Cys Val Met Pro Glu Asp 
    50                  55                  60                  


Val Lys Asn Phe Tyr Leu Met Thr Asn Gly Phe His Met Thr Trp Ser 
65                  70                  75                  80  


Val Lys Leu Asp Glu His Ile Ile Pro Leu Gly Ser Met Ala Ile Asn 
                85                  90                  95      


Ser Ile Ser Lys Leu Thr Gln Leu Thr Gln Ser Ser Met Tyr Ser Leu 
            100                 105                 110         


Pro Asn Ala Pro Thr Leu Ala Asp Leu Glu Asp Asp Thr His Glu Ala 
        115                 120                 125             


Ser Asp Asp Gln Pro Glu Lys Pro His Phe Asp Ser Arg Ser Val Ile 
    130                 135                 140                 


Phe Glu Leu Asp Ser Cys Asn Gly Ser Gly Lys Val Cys Leu Val Tyr 
145                 150                 155                 160 


Lys Ser Gly Lys Pro Ala Leu Ala Glu Asp Thr Glu Ile Trp Phe Leu 
                165                 170                 175     


Asp Arg Ala Leu Tyr Trp His Phe Leu Thr Asp Thr Phe Thr Ala Tyr 
            180                 185                 190         


Tyr Arg Leu Leu Ile Thr His Leu Gly Leu Pro Gln Trp Gln Tyr Ala 
        195                 200                 205             


Phe Thr Ser Tyr Gly Ile Ser Pro Gln Ala Lys Gln Trp Phe Ser Met 
    210                 215                 220                 


Tyr Lys Pro Ile Thr Tyr Asn Thr Asn Leu Leu Thr Glu Glu Thr Asp 
225                 230                 235                 240 


Ser Phe Val Asn Lys Leu Asp Pro Ser Lys Val Phe Lys Ser Lys Asn 
                245                 250                 255     


Lys Ile Val Ile Pro Lys Lys Lys Gly Pro Val Gln Pro Ala Gly Gly 
            260                 265                 270         


Gln Lys Gly Pro Ser Gly Pro Ser Gly Pro Ser Thr Ser Ser Thr Ser 
        275                 280                 285             


Lys Ser Ser Ser Gly Ser Gly Asn Pro Thr Arg Lys 
    290                 295                 300 


<210>  246
<211>  1043
<212>  PRT
<213>  Homo sapiens

<400>  246

Met Glu Leu Gln Lys Gly Lys Gly Ala Ala Ala Ala Ala Ala Ala Ser 
1               5                   10                  15      


Gly Ala Ala Gly Gly Gly Gly Gly Gly Ala Gly Ala Gly Ala Pro Gly 
            20                  25                  30          


Gly Gly Arg Leu Leu Leu Ser Thr Ser Leu Asp Ala Lys Asp Glu Leu 
        35                  40                  45              


Glu Glu Arg Leu Glu Arg Cys Met Ser Ile Val Thr Ser Met Thr Ala 
    50                  55                  60                  


Gly Val Ser Glu Arg Glu Ala Asn Asp Ala Leu Asn Ala Tyr Val Cys 
65                  70                  75                  80  


Lys Gly Leu Pro Gln His Glu Glu Ile Cys Leu Gly Leu Phe Thr Leu 
                85                  90                  95      


Ile Leu Thr Glu Pro Ala Gln Ala Gln Lys Cys Tyr Arg Asp Leu Ala 
            100                 105                 110         


Leu Val Ser Arg Asp Gly Met Asn Ile Val Leu Asn Lys Ile Asn Gln 
        115                 120                 125             


Ile Leu Met Glu Lys Tyr Leu Lys Leu Gln Asp Thr Cys Arg Thr Gln 
    130                 135                 140                 


Leu Val Trp Leu Val Arg Glu Leu Val Lys Ser Gly Val Leu Gly Ala 
145                 150                 155                 160 


Asp Gly Val Cys Met Thr Phe Met Lys Gln Ile Ala Gly Gly Gly Asp 
                165                 170                 175     


Val Thr Ala Lys Asn Ile Trp Leu Ala Glu Ser Val Leu Asp Ile Leu 
            180                 185                 190         


Thr Glu Gln Arg Glu Trp Val Leu Lys Ser Ser Ile Leu Ile Ala Met 
        195                 200                 205             


Ala Val Tyr Thr Tyr Leu Arg Leu Ile Val Asp His His Gly Thr Ala 
    210                 215                 220                 


Gln Leu Gln Ala Leu Arg Gln Lys Glu Val Asp Phe Cys Ile Ser Leu 
225                 230                 235                 240 


Leu Arg Glu Arg Phe Met Glu Cys Leu Met Ile Gly Arg Asp Leu Val 
                245                 250                 255     


Arg Leu Leu Gln Asn Val Ala Arg Ile Pro Glu Phe Glu Leu Leu Trp 
            260                 265                 270         


Lys Asp Ile Ile His Asn Pro Gln Ala Leu Ser Pro Gln Phe Thr Gly 
        275                 280                 285             


Ile Leu Gln Leu Leu Gln Ser Arg Thr Ser Arg Lys Phe Leu Ala Cys 
    290                 295                 300                 


Arg Leu Thr Pro Asp Met Glu Thr Lys Leu Leu Phe Met Thr Ser Arg 
305                 310                 315                 320 


Val Arg Phe Gly Gln Gln Lys Arg Tyr Gln Asp Trp Phe Gln Arg Gln 
                325                 330                 335     


Tyr Leu Ser Thr Pro Asp Ser Gln Ser Leu Arg Cys Asp Leu Ile Arg 
            340                 345                 350         


Tyr Ile Cys Gly Val Val His Pro Ser Asn Glu Val Leu Ser Ser Asp 
        355                 360                 365             


Ile Leu Pro Arg Trp Ala Ile Ile Gly Trp Leu Leu Thr Thr Cys Thr 
    370                 375                 380                 


Ser Asn Val Ala Ala Ser Asn Ala Lys Leu Ala Leu Phe Tyr Asp Trp 
385                 390                 395                 400 


Leu Phe Phe Ser Pro Asp Lys Asp Ser Ile Met Asn Ile Glu Pro Ala 
                405                 410                 415     


Ile Leu Val Met His His Ser Met Lys Pro His Pro Ala Ile Thr Ala 
            420                 425                 430         


Thr Leu Leu Asp Phe Met Cys Arg Ile Ile Pro Asn Phe Tyr Pro Pro 
        435                 440                 445             


Leu Glu Gly His Val Arg Gln Gly Val Phe Ser Ser Leu Asn His Ile 
    450                 455                 460                 


Val Glu Lys Arg Val Leu Ala His Leu Ala Pro Leu Phe Asp Asn Pro 
465                 470                 475                 480 


Lys Leu Asp Lys Glu Leu Arg Ala Met Leu Arg Glu Lys Phe Pro Glu 
                485                 490                 495     


Phe Cys Ser Ser Pro Ser Pro Pro Val Glu Val Lys Ile Glu Glu Pro 
            500                 505                 510         


Val Ser Met Glu Met Asp Asn His Met Ser Asp Lys Asp Glu Ser Cys 
        515                 520                 525             


Tyr Asp Asn Ala Glu Ala Ala Phe Ser Asp Asp Glu Glu Asp Leu Asn 
    530                 535                 540                 


Ser Lys Gly Lys Lys Arg Glu Phe Arg Phe His Pro Ile Lys Glu Thr 
545                 550                 555                 560 


Val Val Glu Glu Pro Val Asp Ile Thr Pro Tyr Leu Asp Gln Leu Asp 
                565                 570                 575     


Glu Ser Leu Arg Asp Lys Val Leu Gln Leu Gln Lys Gly Ser Asp Thr 
            580                 585                 590         


Glu Ala Gln Cys Glu Val Met Gln Glu Ile Val Asp Gln Val Leu Glu 
        595                 600                 605             


Glu Asp Phe Asp Ser Glu Gln Leu Ser Val Leu Ala Ser Cys Leu Gln 
    610                 615                 620                 


Glu Leu Phe Lys Ala His Phe Arg Gly Glu Val Leu Pro Glu Glu Ile 
625                 630                 635                 640 


Thr Glu Glu Ser Leu Glu Glu Ser Val Gly Lys Pro Leu Tyr Leu Ile 
                645                 650                 655     


Phe Arg Asn Leu Cys Gln Met Gln Glu Asp Asn Ser Ser Phe Ser Leu 
            660                 665                 670         


Leu Leu Asp Leu Leu Ser Glu Leu Tyr Gln Lys Gln Pro Lys Ile Gly 
        675                 680                 685             


Tyr His Leu Leu Tyr Tyr Leu Arg Ala Ser Lys Ala Ala Ala Gly Lys 
    690                 695                 700                 


Met Asn Leu Tyr Glu Ser Phe Ala Gln Ala Thr Gln Leu Gly Asp Leu 
705                 710                 715                 720 


His Thr Cys Leu Met Met Asp Met Lys Ala Cys Gln Glu Asp Asp Val 
                725                 730                 735     


Arg Leu Leu Cys His Leu Thr Pro Ser Ile Tyr Thr Glu Phe Pro Asp 
            740                 745                 750         


Glu Thr Leu Arg Ser Gly Glu Leu Leu Asn Met Ile Val Ala Val Ile 
        755                 760                 765             


Asp Ser Ala Gln Leu Gln Glu Leu Val Cys His Val Met Met Gly Asn 
    770                 775                 780                 


Leu Val Met Phe Arg Lys Asp Ser Val Leu Asn Ile Leu Ile Gln Ser 
785                 790                 795                 800 


Leu Asp Trp Glu Thr Phe Glu Gln Tyr Cys Ala Trp Gln Leu Phe Leu 
                805                 810                 815     


Ala His Asn Ile Pro Leu Glu Thr Ile Ile Pro Ile Leu Gln His Leu 
            820                 825                 830         


Lys Tyr Lys Glu His Pro Glu Ala Leu Ser Cys Leu Leu Leu Gln Leu 
        835                 840                 845             


Arg Arg Glu Lys Pro Ser Glu Glu Met Val Lys Met Val Leu Ser Arg 
    850                 855                 860                 


Pro Cys His Pro Asp Asp Gln Phe Thr Thr Ser Ile Leu Arg His Trp 
865                 870                 875                 880 


Cys Met Lys His Asp Glu Leu Leu Ala Glu His Ile Lys Ser Leu Leu 
                885                 890                 895     


Ile Lys Asn Asn Ser Leu Pro Arg Lys Arg Gln Ser Leu Arg Ser Ser 
            900                 905                 910         


Ser Ser Lys Leu Ala Gln Leu Thr Leu Glu Gln Ile Leu Glu His Leu 
        915                 920                 925             


Asp Asn Leu Arg Leu Asn Leu Thr Asn Thr Lys Gln Asn Phe Phe Ser 
    930                 935                 940                 


Gln Thr Pro Ile Leu Gln Ala Leu Gln His Val Gln Ala Ser Cys Asp 
945                 950                 955                 960 


Glu Ala His Lys Met Lys Phe Ser Asp Leu Phe Ser Leu Ala Glu Glu 
                965                 970                 975     


Tyr Glu Asp Ser Ser Thr Lys Pro Pro Lys Ser Arg Arg Lys Ala Ala 
            980                 985                 990         


Leu Ser Ser Pro Arg Ser Arg Lys  Asn Ala Thr Gln Pro  Pro Asn Ala 
        995                 1000                 1005             


Glu Glu  Glu Ser Gly Ser Ser  Ser Ala Ser Glu Glu  Glu Asp Thr 
    1010                 1015                 1020             


Lys Pro  Lys Pro Thr Lys Arg  Lys Arg Lys Gly Ser  Ser Ala Val 
    1025                 1030                 1035             


Gly Ser  Asp Ser Asp 
    1040             


<210>  247
<211>  483
<212>  PRT
<213>  Homo sapiens

<400>  247

Met Ala Gln Ala Asp Ile Ala Leu Ile Gly Leu Ala Val Met Gly Gln 
1               5                   10                  15      


Asn Leu Ile Leu Asn Met Asn Asp His Gly Phe Val Val Cys Ala Phe 
            20                  25                  30          


Asn Arg Thr Val Ser Lys Val Asp Asp Phe Leu Ala Asn Glu Ala Lys 
        35                  40                  45              


Gly Thr Lys Val Val Gly Ala Gln Ser Leu Lys Glu Met Val Ser Lys 
    50                  55                  60                  


Leu Lys Lys Pro Arg Arg Ile Ile Leu Leu Val Lys Ala Gly Gln Ala 
65                  70                  75                  80  


Val Asp Asp Phe Ile Glu Lys Leu Val Pro Leu Leu Asp Thr Gly Asp 
                85                  90                  95      


Ile Ile Ile Asp Gly Gly Asn Ser Glu Tyr Arg Asp Thr Thr Arg Arg 
            100                 105                 110         


Cys Arg Asp Leu Lys Ala Lys Gly Ile Leu Phe Val Gly Ser Gly Val 
        115                 120                 125             


Ser Gly Gly Glu Glu Gly Ala Arg Tyr Gly Pro Ser Leu Met Pro Gly 
    130                 135                 140                 


Gly Asn Lys Glu Ala Trp Pro His Ile Lys Thr Ile Phe Gln Gly Ile 
145                 150                 155                 160 


Ala Ala Lys Val Gly Thr Gly Glu Pro Cys Cys Asp Trp Val Gly Asp 
                165                 170                 175     


Glu Gly Ala Gly His Phe Val Lys Met Val His Asn Gly Ile Glu Tyr 
            180                 185                 190         


Gly Asp Met Gln Leu Ile Cys Glu Ala Tyr His Leu Met Lys Asp Val 
        195                 200                 205             


Leu Gly Met Ala Gln Asp Glu Met Ala Gln Ala Phe Glu Asp Trp Asn 
    210                 215                 220                 


Lys Thr Glu Leu Asp Ser Phe Leu Ile Glu Ile Thr Ala Asn Ile Leu 
225                 230                 235                 240 


Lys Phe Gln Asp Thr Asp Gly Lys His Leu Leu Pro Lys Ile Arg Asp 
                245                 250                 255     


Ser Ala Gly Gln Lys Gly Thr Gly Lys Trp Thr Ala Ile Ser Ala Leu 
            260                 265                 270         


Glu Tyr Gly Val Pro Val Thr Leu Ile Gly Glu Ala Val Phe Ala Arg 
        275                 280                 285             


Cys Leu Ser Ser Leu Lys Asp Glu Arg Ile Gln Ala Ser Lys Lys Leu 
    290                 295                 300                 


Lys Gly Pro Gln Lys Phe Gln Phe Asp Gly Asp Lys Lys Ser Phe Leu 
305                 310                 315                 320 


Glu Asp Ile Arg Lys Ala Leu Tyr Ala Ser Lys Ile Ile Ser Tyr Ala 
                325                 330                 335     


Gln Gly Phe Met Leu Leu Arg Gln Ala Ala Thr Glu Phe Gly Trp Thr 
            340                 345                 350         


Leu Asn Tyr Gly Gly Ile Ala Leu Met Trp Arg Gly Gly Cys Ile Ile 
        355                 360                 365             


Arg Ser Val Phe Leu Gly Lys Ile Lys Asp Ala Phe Asp Arg Asn Pro 
    370                 375                 380                 


Glu Leu Gln Asn Leu Leu Leu Asp Asp Phe Phe Lys Ser Ala Val Glu 
385                 390                 395                 400 


Asn Cys Gln Asp Ser Trp Arg Arg Ala Val Ser Thr Gly Val Gln Ala 
                405                 410                 415     


Gly Ile Pro Met Pro Cys Phe Thr Thr Ala Leu Ser Phe Tyr Asp Gly 
            420                 425                 430         


Tyr Arg His Glu Met Leu Pro Ala Ser Leu Ile Gln Ala Gln Arg Asp 
        435                 440                 445             


Tyr Phe Gly Ala His Thr Tyr Glu Leu Leu Ala Lys Pro Gly Gln Phe 
    450                 455                 460                 


Ile His Thr Asn Trp Thr Gly His Gly Gly Thr Val Ser Ser Ser Ser 
465                 470                 475                 480 


Tyr Asn Ala 
            


<210>  248
<211>  381
<212>  PRT
<213>  Homo sapiens

<400>  248

Met Gly Pro Ile Gly Ala Glu Ala Asp Glu Asn Gln Thr Val Glu Glu 
1               5                   10                  15      


Met Lys Val Glu Gln Tyr Gly Pro Gln Thr Thr Pro Arg Gly Glu Leu 
            20                  25                  30          


Val Pro Asp Pro Glu Pro Glu Leu Ile Asp Ser Thr Lys Leu Ile Glu 
        35                  40                  45              


Val Gln Val Val Leu Ile Leu Ala Tyr Cys Ser Ile Ile Leu Leu Gly 
    50                  55                  60                  


Val Ile Gly Asn Ser Leu Val Ile His Val Val Ile Lys Phe Lys Ser 
65                  70                  75                  80  


Met Arg Thr Val Thr Asn Phe Phe Ile Ala Asn Leu Ala Val Ala Asp 
                85                  90                  95      


Leu Leu Val Asn Thr Leu Cys Leu Pro Phe Thr Leu Thr Tyr Thr Leu 
            100                 105                 110         


Met Gly Glu Trp Lys Met Gly Pro Val Leu Cys His Leu Val Pro Tyr 
        115                 120                 125             


Ala Gln Gly Leu Ala Val Gln Val Ser Thr Ile Thr Leu Thr Val Ile 
    130                 135                 140                 


Ala Leu Asp Arg His Arg Cys Ile Val Tyr His Leu Glu Ser Lys Ile 
145                 150                 155                 160 


Ser Lys Arg Ile Ser Phe Leu Ile Ile Gly Leu Ala Trp Gly Ile Ser 
                165                 170                 175     


Ala Leu Leu Ala Ser Pro Leu Ala Ile Phe Arg Glu Tyr Ser Leu Ile 
            180                 185                 190         


Glu Ile Ile Pro Asp Phe Glu Ile Val Ala Cys Thr Glu Lys Trp Pro 
        195                 200                 205             


Gly Glu Glu Lys Ser Ile Tyr Gly Thr Val Tyr Ser Leu Ser Ser Leu 
    210                 215                 220                 


Leu Ile Leu Tyr Val Leu Pro Leu Gly Ile Ile Ser Phe Ser Tyr Thr 
225                 230                 235                 240 


Arg Ile Trp Ser Lys Leu Lys Asn His Val Ser Pro Gly Ala Ala Asn 
                245                 250                 255     


Asp His Tyr His Gln Arg Arg Gln Lys Thr Thr Lys Met Leu Val Cys 
            260                 265                 270         


Val Val Val Val Phe Ala Val Ser Trp Leu Pro Leu His Ala Phe Gln 
        275                 280                 285             


Leu Ala Val Asp Ile Asp Ser Gln Val Leu Asp Leu Lys Glu Tyr Lys 
    290                 295                 300                 


Leu Ile Phe Thr Val Phe His Ile Ile Ala Met Cys Ser Thr Phe Ala 
305                 310                 315                 320 


Asn Pro Leu Leu Tyr Gly Trp Met Asn Ser Asn Tyr Arg Lys Ala Phe 
                325                 330                 335     


Leu Ser Ala Phe Arg Cys Glu Gln Arg Leu Asp Ala Ile His Ser Glu 
            340                 345                 350         


Val Ser Val Thr Phe Lys Ala Lys Lys Asn Leu Glu Val Arg Lys Asn 
        355                 360                 365             


Ser Gly Pro Asn Asp Ser Phe Thr Glu Ala Thr Asn Val 
    370                 375                 380     


<210>  249
<211>  301
<212>  PRT
<213>  Homo sapiens

<400>  249

Met Leu Ser Glu Gly Tyr Leu Ser Gly Leu Glu Tyr Trp Asn Asp Ile 
1               5                   10                  15      


His Trp Ser Cys Ala Ser Tyr Asn Glu Gln Val Ala Gly Glu Lys Glu 
            20                  25                  30          


Glu Glu Thr Asn Ser Val Ala Thr Leu Ser Tyr Ser Ser Val Asp Glu 
        35                  40                  45              


Thr Gln Val Arg Ser Leu Tyr Val Ser Cys Lys Ser Ser Gly Lys Phe 
    50                  55                  60                  


Ile Ser Ser Val His Ser Arg Glu Ser Gln His Ser Arg Ser Gln Arg 
65                  70                  75                  80  


Val Thr Val Leu Gln Thr Asn Pro Asn Pro Val Phe Glu Ser Pro Asn 
                85                  90                  95      


Leu Ala Ala Val Glu Ile Cys Arg Asp Ala Ser Arg Glu Thr Tyr Leu 
            100                 105                 110         


Val Pro Ser Ser Cys Lys Ser Ile Cys Lys Asn Tyr Asn Asp Leu Gln 
        115                 120                 125             


Ile Ala Gly Gly Gln Val Met Ala Ile Asn Ser Val Thr Thr Asp Phe 
    130                 135                 140                 


Pro Ser Glu Ser Ser Phe Glu Tyr Gly Pro Leu Leu Lys Ser Ser Glu 
145                 150                 155                 160 


Ile Pro Leu Pro Met Glu Asp Ser Ile Ser Thr Gln Pro Ser Asp Phe 
                165                 170                 175     


Pro Gln Lys Pro Ile Gln Arg Tyr Ser Ser Tyr Trp Arg Ile Thr Ser 
            180                 185                 190         


Ile Lys Glu Lys Ser Ser Leu Gln Met Gln Asn Pro Ile Ser Asn Ala 
        195                 200                 205             


Val Leu Asn Glu Tyr Leu Glu Gln Lys Val Val Glu Leu Tyr Lys Gln 
    210                 215                 220                 


Tyr Ile Met Asp Thr Val Phe His Asp Ser Ser Pro Thr Gln Ile Leu 
225                 230                 235                 240 


Ala Ser Glu Leu Ile Met Thr Ser Val Asp Gln Ile Ser Leu Gln Val 
                245                 250                 255     


Ser Arg Glu Lys Asn Leu Glu Thr Ser Lys Ala Arg Asp Ile Val Phe 
            260                 265                 270         


Ser Arg Leu Leu Gln Leu Met Ser Thr Glu Ile Thr Glu Ile Ser Thr 
        275                 280                 285             


Pro Ser Leu His Ile Ser Gln Tyr Ser Asn Val Asn Pro 
    290                 295                 300     


<210>  250
<211>  346
<212>  PRT
<213>  Homo sapiens

<400>  250

Met Cys Glu Gly Pro Ser Arg Ile Ser Gly Pro Ile Pro Pro Asp Pro 
1               5                   10                  15      


Thr Leu Cys Pro Asp Asn Tyr Arg Arg Pro Thr Ser Ala Gln Gly Arg 
            20                  25                  30          


Leu Glu Gly Asn Ala Leu Lys Leu Asp Leu Leu Thr Ser Asp Arg Ala 
        35                  40                  45              


Leu Asp Thr Thr Ala Pro Arg Gly Pro Cys Ile Gly Pro Gly Ala Gly 
    50                  55                  60                  


Glu Ile Leu Glu Arg Gly Gln Arg Gly Val Gly Asp Val Leu Leu Gln 
65                  70                  75                  80  


Leu Glu Gly Ile Ser Leu Gly Pro Gly Ala Ser Leu Lys Arg Lys Asp 
                85                  90                  95      


Pro Lys Asp His Glu Lys Glu Asn Leu Arg Arg Ile Arg Glu Ile Gln 
            100                 105                 110         


Lys Arg Phe Arg Glu Gln Glu Arg Ser Arg Glu Gln Gly Gln Pro Arg 
        115                 120                 125             


Pro Leu Lys Ala Leu Trp Arg Ser Pro Lys Tyr Asp Lys Val Glu Ser 
    130                 135                 140                 


Arg Val Lys Ala Gln Leu Gln Glu Pro Gly Pro Ala Ser Gly Thr Glu 
145                 150                 155                 160 


Ser Ala His Phe Leu Arg Ala His Ser Arg Cys Gly Pro Gly Leu Pro 
                165                 170                 175     


Pro Pro His Val Ser Ser Pro Gln Pro Thr Pro Pro Gly Pro Glu Ala 
            180                 185                 190         


Lys Glu Pro Gly Leu Gly Val Asp Phe Ile Arg His Asn Ala Arg Ala 
        195                 200                 205             


Ala Lys Arg Ala Pro Arg Arg His Ser Cys Ser Leu Gln Val Leu Ala 
    210                 215                 220                 


Gln Val Leu Glu Gln Gln Arg Gln Ala Gln Glu His Tyr Asn Ala Thr 
225                 230                 235                 240 


Gln Lys Gly His Val Pro His Tyr Leu Leu Glu Arg Arg Asp Leu Trp 
                245                 250                 255     


Arg Arg Glu Ala Glu Ala Arg Lys Gln Ser Gln Pro Asp Pro Ala Met 
            260                 265                 270         


Pro Pro Gly His Thr Arg Met Pro Glu Asn Gln Arg Leu Glu Thr Leu 
        275                 280                 285             


Thr Lys Leu Leu Gln Ser Gln Ser Gln Leu Leu Arg Glu Leu Val Leu 
    290                 295                 300                 


Leu Pro Ala Gly Ala Asp Ser Leu Arg Ala Gln Ser His Arg Ala Glu 
305                 310                 315                 320 


Leu Asp Arg Lys Leu Val Gln Val Glu Glu Ala Ile Lys Ile Phe Ser 
                325                 330                 335     


Arg Pro Lys Val Phe Val Lys Met Asp Asp 
            340                 345     


<210>  251
<211>  776
<212>  PRT
<213>  Homo sapiens

<400>  251

Met Ser Thr Arg Thr Pro Leu Pro Thr Val Asn Glu Arg Asp Thr Glu 
1               5                   10                  15      


Asn His Thr Ser His Gly Asp Gly Arg Gln Glu Val Thr Ser Arg Thr 
            20                  25                  30          


Ser Arg Ser Gly Ala Arg Cys Arg Asn Ser Ile Ala Ser Cys Ala Asp 
        35                  40                  45              


Glu Gln Pro His Ile Gly Asn Tyr Arg Leu Leu Lys Thr Ile Gly Lys 
    50                  55                  60                  


Gly Asn Phe Ala Lys Val Lys Leu Ala Arg His Ile Leu Thr Gly Arg 
65                  70                  75                  80  


Glu Val Ala Ile Lys Ile Ile Asp Lys Thr Gln Leu Asn Pro Thr Ser 
                85                  90                  95      


Leu Gln Lys Leu Phe Arg Glu Val Arg Ile Met Lys Ile Leu Asn His 
            100                 105                 110         


Pro Asn Ile Val Lys Leu Phe Glu Val Ile Glu Thr Glu Lys Thr Leu 
        115                 120                 125             


Tyr Leu Ile Met Glu Tyr Ala Ser Gly Gly Glu Val Phe Asp Tyr Leu 
    130                 135                 140                 


Val Ala His Gly Arg Met Lys Glu Lys Glu Ala Arg Ser Lys Phe Arg 
145                 150                 155                 160 


Gln Gly Cys Gln Ala Gly Gln Thr Ile Lys Val Gln Val Ser Phe Asp 
                165                 170                 175     


Leu Leu Ser Leu Met Phe Thr Phe Ile Val Ser Ala Val Gln Tyr Cys 
            180                 185                 190         


His Gln Lys Arg Ile Val His Arg Asp Leu Lys Ala Glu Asn Leu Leu 
        195                 200                 205             


Leu Asp Ala Asp Met Asn Ile Lys Ile Ala Asp Phe Gly Phe Ser Asn 
    210                 215                 220                 


Glu Phe Thr Val Gly Gly Lys Leu Asp Thr Phe Cys Gly Ser Pro Pro 
225                 230                 235                 240 


Tyr Ala Ala Pro Glu Leu Phe Gln Gly Lys Lys Tyr Asp Gly Pro Glu 
                245                 250                 255     


Val Asp Val Trp Ser Leu Gly Val Ile Leu Tyr Thr Leu Val Ser Gly 
            260                 265                 270         


Ser Leu Pro Phe Asp Gly Gln Asn Leu Lys Glu Leu Arg Glu Arg Val 
        275                 280                 285             


Leu Arg Gly Lys Tyr Arg Ile Pro Phe Tyr Met Ser Thr Asp Cys Glu 
    290                 295                 300                 


Asn Leu Leu Lys Arg Phe Leu Val Leu Asn Pro Ile Lys Arg Gly Thr 
305                 310                 315                 320 


Leu Glu Gln Ile Met Lys Asp Arg Trp Ile Asn Ala Gly His Glu Glu 
                325                 330                 335     


Asp Glu Leu Lys Pro Phe Val Glu Pro Glu Leu Asp Ile Ser Asp Gln 
            340                 345                 350         


Lys Arg Ile Asp Ile Met Val Gly Met Gly Tyr Ser Gln Glu Glu Ile 
        355                 360                 365             


Gln Glu Ser Leu Ser Lys Met Lys Tyr Asp Glu Ile Thr Ala Thr Tyr 
    370                 375                 380                 


Leu Leu Leu Gly Arg Lys Ser Ser Glu Leu Asp Ala Ser Asp Ser Ser 
385                 390                 395                 400 


Ser Ser Ser Asn Leu Ser Leu Ala Lys Val Arg Pro Ser Ser Asp Leu 
                405                 410                 415     


Asn Asn Ser Thr Gly Gln Ser Pro His His Lys Val Gln Arg Ser Val 
            420                 425                 430         


Ser Ser Ser Gln Lys Gln Arg Arg Tyr Ser Asp His Ala Gly Pro Ala 
        435                 440                 445             


Ile Pro Ser Val Val Ala Tyr Pro Lys Arg Ser Gln Thr Ser Thr Ala 
    450                 455                 460                 


Asp Ser Asp Leu Lys Glu Asp Gly Ile Ser Ser Arg Lys Ser Ser Gly 
465                 470                 475                 480 


Ser Ala Val Gly Gly Lys Gly Ile Ala Pro Ala Ser Pro Met Leu Gly 
                485                 490                 495     


Asn Ala Ser Asn Pro Asn Lys Ala Asp Ile Pro Glu Arg Lys Lys Ser 
            500                 505                 510         


Ser Thr Val Pro Ser Ser Asn Thr Ala Ser Gly Gly Met Thr Arg Arg 
        515                 520                 525             


Asn Thr Tyr Val Cys Ser Glu Arg Thr Thr Ala Asp Arg His Ser Val 
    530                 535                 540                 


Ile Gln Asn Gly Lys Glu Asn Ser Thr Ile Pro Asp Gln Arg Thr Pro 
545                 550                 555                 560 


Val Ala Ser Thr His Ser Ile Ser Ser Ala Ala Thr Pro Asp Arg Ile 
                565                 570                 575     


Arg Phe Pro Arg Gly Thr Ala Ser Arg Ser Thr Phe His Gly Gln Pro 
            580                 585                 590         


Arg Glu Arg Arg Thr Ala Thr Tyr Asn Gly Pro Pro Ala Ser Pro Ser 
        595                 600                 605             


Leu Ser His Glu Ala Thr Pro Leu Ser Gln Thr Arg Ser Arg Gly Ser 
    610                 615                 620                 


Thr Asn Leu Phe Ser Lys Leu Thr Ser Lys Leu Thr Arg Arg Asn Met 
625                 630                 635                 640 


Ser Phe Arg Phe Ile Lys Arg Leu Pro Thr Glu Tyr Glu Arg Asn Gly 
                645                 650                 655     


Arg Tyr Glu Gly Ser Ser Arg Asn Val Ser Ala Glu Gln Lys Asp Glu 
            660                 665                 670         


Asn Lys Glu Ala Lys Pro Arg Ser Leu Arg Phe Thr Trp Ser Met Lys 
        675                 680                 685             


Thr Thr Ser Ser Met Asp Pro Gly Asp Met Met Arg Glu Ile Arg Lys 
    690                 695                 700                 


Val Leu Asp Ala Asn Asn Cys Asp Tyr Glu Gln Arg Glu Arg Phe Leu 
705                 710                 715                 720 


Leu Phe Cys Val His Gly Asp Gly His Ala Glu Asn Leu Val Gln Trp 
                725                 730                 735     


Glu Met Glu Val Cys Lys Leu Pro Arg Leu Ser Leu Asn Gly Val Arg 
            740                 745                 750         


Phe Lys Arg Ile Ser Gly Thr Ser Ile Ala Phe Lys Asn Ile Ala Ser 
        755                 760                 765             


Lys Ile Ala Asn Glu Leu Lys Leu 
    770                 775     


<210>  252
<211>  364
<212>  PRT
<213>  Homo sapiens

<400>  252

Met Ser Ala Asn Ser Ser Arg Val Gly Gln Leu Leu Leu Gln Gly Ser 
1               5                   10                  15      


Ala Cys Ile Arg Trp Lys Gln Asp Val Glu Gly Ala Val Tyr His Leu 
            20                  25                  30          


Ala Asn Cys Leu Leu Leu Leu Gly Phe Met Gly Gly Ser Gly Val Tyr 
        35                  40                  45              


Gly Cys Phe Tyr Leu Phe Gly Phe Leu Ser Ala Gly Tyr Leu Cys Cys 
    50                  55                  60                  


Val Leu Trp Gly Trp Phe Ser Ala Cys Gly Leu Asp Ile Val Leu Trp 
65                  70                  75                  80  


Ser Phe Leu Leu Ala Val Val Cys Leu Leu Gln Leu Ala His Leu Val 
                85                  90                  95      


Tyr Arg Leu Arg Glu Asp Thr Leu Pro Glu Glu Phe Asp Leu Leu Tyr 
            100                 105                 110         


Lys Thr Leu Cys Leu Pro Leu Gln Val Pro Leu Gln Thr Tyr Lys Glu 
        115                 120                 125             


Ile Val His Cys Cys Glu Glu Gln Val Leu Thr Leu Ala Thr Glu Gln 
    130                 135                 140                 


Thr Tyr Ala Val Glu Gly Glu Thr Pro Ile Asn Arg Leu Ser Leu Leu 
145                 150                 155                 160 


Leu Ser Gly Arg Val Arg Val Ser Gln Asp Gly Gln Phe Leu His Tyr 
                165                 170                 175     


Ile Phe Pro Tyr Gln Phe Met Asp Ser Pro Glu Trp Glu Ser Leu Gln 
            180                 185                 190         


Pro Ser Glu Glu Gly Val Phe Gln Val Thr Leu Thr Ala Glu Thr Ser 
        195                 200                 205             


Cys Ser Tyr Ile Ser Trp Pro Arg Lys Ser Leu His Leu Leu Leu Thr 
    210                 215                 220                 


Lys Glu Arg Tyr Ile Ser Cys Leu Phe Ser Ala Leu Leu Gly Tyr Asp 
225                 230                 235                 240 


Ile Ser Glu Lys Leu Tyr Thr Leu Asn Asp Lys Leu Phe Ala Lys Phe 
                245                 250                 255     


Gly Leu Arg Phe Asp Ile Arg Leu Pro Ser Leu Tyr His Val Leu Gly 
            260                 265                 270         


Pro Thr Ala Ala Asp Ala Gly Pro Glu Ser Glu Lys Gly Asp Glu Glu 
        275                 280                 285             


Val Cys Glu Pro Ala Val Ser Pro Pro Gln Ala Thr Pro Thr Ser Leu 
    290                 295                 300                 


Gln Gln Thr Pro Pro Cys Ser Thr Pro Pro Ala Thr Thr Asn Phe Pro 
305                 310                 315                 320 


Ala Pro Pro Thr Arg Ala Arg Leu Ser Arg Pro Asp Ser Gly Ile Leu 
                325                 330                 335     


Ala Ser Arg Ile Pro Leu Gln Ser Tyr Ser Gln Val Ile Ser Arg Gly 
            340                 345                 350         


Gln Ala Pro Leu Ala Pro Thr His Thr Pro Glu Leu 
        355                 360                 


<210>  253
<211>  140
<212>  PRT
<213>  Homo sapiens

<400>  253

Met Asp Val Phe Met Lys Gly Leu Ser Lys Ala Lys Glu Gly Val Val 
1               5                   10                  15      


Ala Ala Ala Glu Lys Thr Lys Gln Gly Val Ala Glu Ala Ala Gly Lys 
            20                  25                  30          


Thr Lys Glu Gly Val Leu Tyr Val Gly Ser Lys Thr Lys Glu Gly Val 
        35                  40                  45              


Val His Gly Val Ala Thr Val Ala Glu Lys Thr Lys Glu Gln Val Thr 
    50                  55                  60                  


Asn Val Gly Gly Ala Val Val Thr Gly Val Thr Ala Val Ala Gln Lys 
65                  70                  75                  80  


Thr Val Glu Gly Ala Gly Ser Ile Ala Ala Ala Thr Gly Phe Val Lys 
                85                  90                  95      


Lys Asp Gln Leu Gly Lys Asn Glu Glu Gly Ala Pro Gln Glu Gly Ile 
            100                 105                 110         


Leu Glu Asp Met Pro Val Asp Pro Asp Asn Glu Ala Tyr Glu Met Pro 
        115                 120                 125             


Ser Glu Glu Gly Tyr Gln Asp Tyr Glu Pro Glu Ala 
    130                 135                 140 


<210>  254
<211>  347
<212>  PRT
<213>  Homo sapiens

<400>  254

Met Glu Ser Pro Ala Ser Ser Gln Pro Ala Ser Met Pro Gln Ser Lys 
1               5                   10                  15      


Gly Lys Ser Lys Arg Lys Lys Asp Leu Arg Ile Ser Cys Met Ser Lys 
            20                  25                  30          


Pro Pro Ala Pro Asn Pro Thr Pro Pro Arg Asn Leu Asp Ser Arg Thr 
        35                  40                  45              


Phe Ile Thr Ile Gly Asp Arg Asn Phe Glu Val Glu Ala Asp Asp Leu 
    50                  55                  60                  


Val Thr Ile Ser Glu Leu Gly Arg Gly Ala Tyr Gly Val Val Glu Lys 
65                  70                  75                  80  


Val Arg His Ala Gln Ser Gly Thr Ile Met Ala Val Lys Arg Ile Arg 
                85                  90                  95      


Ala Thr Val Asn Ser Gln Glu Gln Lys Arg Leu Leu Met Asp Leu Asp 
            100                 105                 110         


Ile Asn Met Arg Thr Val Asp Cys Phe Tyr Thr Val Thr Phe Tyr Gly 
        115                 120                 125             


Ala Leu Phe Arg Glu Gly Asp Val Trp Ile Cys Met Glu Leu Met Asp 
    130                 135                 140                 


Thr Ser Leu Asp Lys Phe Tyr Arg Lys Val Leu Asp Lys Asn Met Thr 
145                 150                 155                 160 


Ile Pro Glu Asp Ile Leu Gly Glu Ile Ala Val Ser Ile Val Arg Ala 
                165                 170                 175     


Leu Glu His Leu His Ser Lys Leu Ser Val Ile His Arg Asp Val Lys 
            180                 185                 190         


Pro Ser Asn Val Leu Ile Asn Lys Glu Gly His Val Lys Met Cys Asp 
        195                 200                 205             


Phe Gly Ile Ser Gly Tyr Leu Val Asp Ser Val Ala Lys Thr Met Asp 
    210                 215                 220                 


Ala Gly Cys Lys Pro Tyr Met Ala Pro Glu Arg Ile Asn Pro Glu Leu 
225                 230                 235                 240 


Asn Gln Lys Gly Tyr Asn Val Lys Ser Asp Val Trp Ser Leu Gly Ile 
                245                 250                 255     


Thr Met Ile Glu Met Ala Ile Leu Arg Phe Pro Tyr Glu Ser Trp Gly 
            260                 265                 270         


Thr Pro Phe Gln Gln Leu Lys Gln Val Val Glu Glu Pro Ser Pro Gln 
        275                 280                 285             


Leu Pro Ala Asp Arg Phe Ser Pro Glu Phe Val Asp Phe Thr Ala Gln 
    290                 295                 300                 


Cys Leu Arg Lys Asn Pro Ala Glu Arg Met Ser Tyr Leu Glu Leu Met 
305                 310                 315                 320 


Glu His Pro Phe Phe Thr Leu His Lys Thr Lys Lys Thr Asp Ile Ala 
                325                 330                 335     


Ala Phe Val Lys Glu Ile Leu Gly Glu Asp Ser 
            340                 345         


<210>  255
<211>  579
<212>  PRT
<213>  Homo sapiens

<400>  255

Met Ala Gln Glu Val Ser Glu Tyr Leu Ser Gln Asn Pro Arg Val Ala 
1               5                   10                  15      


Ala Trp Val Glu Ala Leu Arg Cys Asp Gly Glu Thr Asp Lys His Trp 
            20                  25                  30          


Arg His Arg Arg Asp Phe Leu Leu Arg Asn Ala Gly Asp Leu Ala Pro 
        35                  40                  45              


Ala Gly Gly Ala Ala Ser Ala Ser Thr Asp Glu Ala Ala Asp Ala Glu 
    50                  55                  60                  


Ser Gly Thr Arg Asn Arg Gln Leu Gln Gln Leu Ile Ser Phe Ser Met 
65                  70                  75                  80  


Ala Trp Ala Asn His Val Phe Leu Gly Cys Arg Tyr Pro Gln Lys Val 
                85                  90                  95      


Met Asp Lys Ile Leu Ser Met Ala Glu Gly Ile Lys Val Thr Asp Ala 
            100                 105                 110         


Pro Thr Tyr Thr Thr Arg Asp Glu Leu Val Ala Lys Val Lys Lys Arg 
        115                 120                 125             


Gly Ile Ser Ser Ser Asn Glu Gly Val Glu Glu Pro Ser Lys Lys Arg 
    130                 135                 140                 


Val Ile Glu Gly Lys Asn Ser Ser Ala Val Glu Gln Asp His Ala Lys 
145                 150                 155                 160 


Thr Ser Ala Lys Thr Glu Arg Ala Ser Ala Gln Gln Glu Asn Ser Ser 
                165                 170                 175     


Thr Cys Ile Gly Ser Ala Ile Lys Ser Glu Ser Gly Asn Ser Ala Arg 
            180                 185                 190         


Ser Ser Gly Ile Ser Ser Gln Asn Ser Ser Thr Ser Asp Gly Asp Arg 
        195                 200                 205             


Ser Val Ser Ser Gln Ser Ser Ser Ser Val Ser Ser Gln Val Thr Thr 
    210                 215                 220                 


Ala Gly Ser Gly Lys Ala Ser Glu Ala Glu Ala Pro Asp Lys His Gly 
225                 230                 235                 240 


Ser Ser Phe Val Ser Leu Leu Lys Ser Ser Val Asn Ser His Met Thr 
                245                 250                 255     


Gln Ser Thr Asp Ser Arg Gln Gln Ser Gly Ser Pro Lys Lys Ser Ala 
            260                 265                 270         


Leu Glu Gly Ser Ser Ala Ser Ala Ser Gln Ser Ser Ser Glu Ile Glu 
        275                 280                 285             


Val Pro Leu Leu Gly Ser Ser Gly Ser Ser Glu Val Glu Leu Pro Leu 
    290                 295                 300                 


Leu Ser Ser Lys Pro Ser Ser Glu Thr Ala Ser Ser Gly Leu Thr Ser 
305                 310                 315                 320 


Lys Thr Ser Ser Glu Ala Ser Val Ser Ser Ser Val Ala Lys Asn Ser 
                325                 330                 335     


Ser Ser Ser Gly Thr Ser Leu Leu Thr Pro Lys Ser Ser Ser Ser Thr 
            340                 345                 350         


Asn Thr Ser Leu Leu Thr Ser Lys Ser Thr Ser Gln Val Ala Ala Ser 
        355                 360                 365             


Leu Leu Ala Ser Lys Ser Ser Ser Gln Thr Ser Gly Ser Leu Val Ser 
    370                 375                 380                 


Lys Ser Thr Ser Leu Ala Ser Val Ser Gln Leu Ala Ser Lys Ser Ser 
385                 390                 395                 400 


Ser Gln Thr Ser Thr Ser Gln Leu Pro Ser Lys Ser Thr Ser Gln Ser 
                405                 410                 415     


Ser Glu Ser Ser Val Lys Phe Ser Cys Lys Leu Thr Asn Glu Asp Val 
            420                 425                 430         


Lys Gln Lys Gln Pro Phe Phe Asn Arg Leu Tyr Lys Thr Val Ala Trp 
        435                 440                 445             


Lys Leu Val Ala Val Gly Gly Phe Ser Pro Asn Val Asn His Gly Glu 
    450                 455                 460                 


Leu Leu Asn Ala Ala Ile Glu Ala Leu Lys Ala Thr Leu Asp Val Phe 
465                 470                 475                 480 


Phe Val Pro Leu Lys Glu Leu Ala Asp Leu Pro Gln Asn Lys Ser Ser 
                485                 490                 495     


Gln Glu Ser Ile Val Cys Glu Leu Arg Cys Lys Ser Val Tyr Leu Gly 
            500                 505                 510         


Thr Gly Cys Gly Lys Ser Lys Glu Asn Ala Lys Ala Val Ala Ser Arg 
        515                 520                 525             


Glu Ala Leu Lys Leu Phe Leu Lys Lys Lys Val Val Val Lys Ile Cys 
    530                 535                 540                 


Lys Arg Lys Tyr Arg Gly Ser Glu Ile Glu Asp Leu Val Leu Leu Asp 
545                 550                 555                 560 


Glu Glu Ser Arg Pro Val Asn Leu Pro Pro Ala Leu Lys His Pro Gln 
                565                 570                 575     


Glu Leu Leu 
            


<210>  256
<211>  282
<212>  PRT
<213>  Homo sapiens

<400>  256

Met Asn Ser Ser Thr Ser Thr Met Ser Glu Glu Pro Asp Ala Leu Ser 
1               5                   10                  15      


Val Val Asn Gln Leu Arg Asp Leu Ala Ala Asp Pro Leu Asn Arg Arg 
            20                  25                  30          


Ala Ile Val Gln Asp Gln Gly Cys Leu Pro Gly Leu Ile Leu Phe Met 
        35                  40                  45              


Asp His Pro Asn Pro Pro Val Val His Ser Ala Leu Leu Ala Leu Arg 
    50                  55                  60                  


Tyr Leu Ala Glu Cys Arg Ala Asn Arg Glu Lys Met Lys Gly Glu Leu 
65                  70                  75                  80  


Gly Met Met Leu Ser Leu Gln Asn Val Ile Gln Lys Thr Thr Thr Pro 
                85                  90                  95      


Gly Glu Thr Lys Leu Leu Ala Ser Glu Ile Tyr Asp Ile Leu Gln Ser 
            100                 105                 110         


Ser Asn Met Ala Asp Gly Asp Ser Phe Asn Glu Met Asn Ser Arg Arg 
        115                 120                 125             


Arg Lys Ala Gln Phe Phe Leu Gly Thr Thr Asn Lys Arg Ala Lys Thr 
    130                 135                 140                 


Val Val Leu His Ile Asp Gly Leu Asp Asp Thr Ser Arg Arg Asn Leu 
145                 150                 155                 160 


Cys Glu Glu Ala Leu Leu Lys Ile Lys Gly Val Ile Ser Phe Thr Phe 
                165                 170                 175     


Gln Met Ala Val Gln Arg Cys Val Val Arg Ile Arg Ser Asp Leu Lys 
            180                 185                 190         


Ala Glu Ala Leu Ala Ser Ala Ile Ala Ser Thr Lys Val Met Lys Ala 
        195                 200                 205             


Gln Gln Val Val Lys Ser Glu Ser Gly Glu Glu Met Leu Val Pro Phe 
    210                 215                 220                 


Gln Asp Thr Pro Val Glu Val Glu Gln Asn Thr Glu Leu Pro Asp Tyr 
225                 230                 235                 240 


Leu Pro Glu Asp Glu Ser Pro Thr Lys Glu Gln Asp Lys Ala Val Ser 
                245                 250                 255     


Arg Val Gly Ser His Pro Glu Gly Gly Ala Ser Trp Leu Ser Thr Ala 
            260                 265                 270         


Ala Asn Phe Leu Ser Arg Ser Phe Tyr Trp 
        275                 280         


<210>  257
<211>  254
<212>  PRT
<213>  Homo sapiens

<400>  257

Met Ser Leu Ala Arg Gly His Gly Asp Thr Ala Ala Ser Thr Ala Ala 
1               5                   10                  15      


Pro Leu Ser Glu Glu Gly Glu Val Thr Ser Gly Leu Gln Ala Leu Ala 
            20                  25                  30          


Val Glu Asp Thr Gly Gly Pro Ser Ala Ser Ala Gly Lys Ala Glu Asp 
        35                  40                  45              


Glu Gly Glu Gly Gly Arg Glu Glu Thr Glu Arg Glu Gly Ser Gly Gly 
    50                  55                  60                  


Glu Glu Ala Gln Gly Glu Val Pro Ser Ala Gly Gly Glu Glu Pro Ala 
65                  70                  75                  80  


Glu Glu Asp Ser Glu Asp Trp Cys Val Pro Cys Ser Asp Glu Glu Val 
                85                  90                  95      


Glu Leu Pro Ala Asp Gly Gln Pro Trp Met Pro Pro Pro Ser Glu Ile 
            100                 105                 110         


Gln Arg Leu Tyr Glu Leu Leu Ala Ala His Gly Thr Leu Glu Leu Gln 
        115                 120                 125             


Ala Glu Ile Leu Pro Arg Arg Pro Pro Thr Pro Glu Ala Gln Ser Glu 
    130                 135                 140                 


Glu Glu Arg Ser Asp Glu Glu Pro Glu Ala Lys Glu Glu Glu Glu Glu 
145                 150                 155                 160 


Lys Pro His Met Pro Thr Glu Phe Asp Phe Asp Asp Glu Pro Val Thr 
                165                 170                 175     


Pro Lys Asp Ser Leu Ile Asp Arg Arg Arg Thr Pro Gly Ser Ser Ala 
            180                 185                 190         


Arg Ser Gln Lys Arg Glu Ala Arg Leu Asp Lys Val Leu Ser Asp Met 
        195                 200                 205             


Lys Arg His Lys Lys Leu Glu Glu Gln Ile Leu Arg Thr Gly Arg Asp 
    210                 215                 220                 


Leu Phe Ser Leu Asp Ser Glu Asp Pro Ser Pro Ala Ser Pro Pro Leu 
225                 230                 235                 240 


Arg Ser Ser Gly Ser Ser Leu Phe Pro Arg Gln Arg Lys Tyr 
                245                 250                 


<210>  258
<211>  659
<212>  PRT
<213>  Homo sapiens

<400>  258

Met Ala Ala Val Ile Leu Glu Ser Ile Phe Leu Lys Arg Ser Gln Gln 
1               5                   10                  15      


Lys Lys Lys Thr Ser Pro Leu Asn Phe Lys Lys Arg Leu Phe Leu Leu 
            20                  25                  30          


Thr Val His Lys Leu Ser Tyr Tyr Glu Tyr Asp Phe Glu Arg Gly Arg 
        35                  40                  45              


Arg Gly Ser Lys Lys Gly Ser Ile Asp Val Glu Lys Ile Thr Cys Val 
    50                  55                  60                  


Glu Thr Val Val Pro Glu Lys Asn Pro Pro Pro Glu Arg Gln Ile Pro 
65                  70                  75                  80  


Arg Arg Gly Glu Glu Ser Ser Glu Met Glu Gln Ile Ser Ile Ile Glu 
                85                  90                  95      


Arg Phe Pro Tyr Pro Phe Gln Val Val Tyr Asp Glu Gly Pro Leu Tyr 
            100                 105                 110         


Val Phe Ser Pro Thr Glu Glu Leu Arg Lys Arg Trp Ile His Gln Leu 
        115                 120                 125             


Lys Asn Val Ile Arg Tyr Asn Ser Asp Leu Val Gln Lys Tyr His Pro 
    130                 135                 140                 


Cys Phe Trp Ile Asp Gly Gln Tyr Leu Cys Cys Ser Gln Thr Ala Lys 
145                 150                 155                 160 


Asn Ala Met Gly Cys Gln Ile Leu Glu Asn Arg Asn Gly Ser Leu Lys 
                165                 170                 175     


Pro Gly Ser Ser His Arg Lys Thr Lys Lys Pro Leu Pro Pro Thr Pro 
            180                 185                 190         


Glu Glu Asp Gln Ile Leu Lys Lys Pro Leu Pro Pro Glu Pro Ala Ala 
        195                 200                 205             


Ala Pro Val Ser Thr Ser Glu Leu Lys Lys Val Val Ala Leu Tyr Asp 
    210                 215                 220                 


Tyr Met Pro Met Asn Ala Asn Asp Leu Gln Leu Arg Lys Gly Asp Glu 
225                 230                 235                 240 


Tyr Phe Ile Leu Glu Glu Ser Asn Leu Pro Trp Trp Arg Ala Arg Asp 
                245                 250                 255     


Lys Asn Gly Gln Glu Gly Tyr Ile Pro Ser Asn Tyr Val Thr Glu Ala 
            260                 265                 270         


Glu Asp Ser Ile Glu Met Tyr Glu Trp Tyr Ser Lys His Met Thr Arg 
        275                 280                 285             


Ser Gln Ala Glu Gln Leu Leu Lys Gln Glu Gly Lys Glu Gly Gly Phe 
    290                 295                 300                 


Ile Val Arg Asp Ser Ser Lys Ala Gly Lys Tyr Thr Val Ser Val Phe 
305                 310                 315                 320 


Ala Lys Ser Thr Gly Asp Pro Gln Gly Val Ile Arg His Tyr Val Val 
                325                 330                 335     


Cys Ser Thr Pro Gln Ser Gln Tyr Tyr Leu Ala Glu Lys His Leu Phe 
            340                 345                 350         


Ser Thr Ile Pro Glu Leu Ile Asn Tyr His Gln His Asn Ser Ala Gly 
        355                 360                 365             


Leu Ile Ser Arg Leu Lys Tyr Pro Val Ser Gln Gln Asn Lys Asn Ala 
    370                 375                 380                 


Pro Ser Thr Ala Gly Leu Gly Tyr Gly Ser Trp Glu Ile Asp Pro Lys 
385                 390                 395                 400 


Asp Leu Thr Phe Leu Lys Glu Leu Gly Thr Gly Gln Phe Gly Val Val 
                405                 410                 415     


Lys Tyr Gly Lys Trp Arg Gly Gln Tyr Asp Val Ala Ile Lys Met Ile 
            420                 425                 430         


Lys Glu Gly Ser Met Ser Glu Asp Glu Phe Ile Glu Glu Ala Lys Val 
        435                 440                 445             


Met Met Asn Leu Ser His Glu Lys Leu Val Gln Leu Tyr Gly Val Cys 
    450                 455                 460                 


Thr Lys Gln Arg Pro Ile Phe Ile Ile Thr Glu Tyr Met Ala Asn Gly 
465                 470                 475                 480 


Cys Leu Leu Asn Tyr Leu Arg Glu Met Arg His Arg Phe Gln Thr Gln 
                485                 490                 495     


Gln Leu Leu Glu Met Cys Lys Asp Val Cys Glu Ala Met Glu Tyr Leu 
            500                 505                 510         


Glu Ser Lys Gln Phe Leu His Arg Asp Leu Ala Ala Arg Asn Cys Leu 
        515                 520                 525             


Val Asn Asp Gln Gly Val Val Lys Val Ser Asp Phe Gly Leu Ser Arg 
    530                 535                 540                 


Tyr Val Leu Asp Asp Glu Tyr Thr Ser Ser Val Gly Ser Lys Phe Pro 
545                 550                 555                 560 


Val Arg Trp Ser Pro Pro Glu Val Leu Met Tyr Ser Lys Phe Ser Ser 
                565                 570                 575     


Lys Ser Asp Ile Trp Ala Phe Gly Val Leu Met Trp Glu Ile Tyr Ser 
            580                 585                 590         


Leu Gly Lys Met Pro Tyr Glu Arg Phe Thr Asn Ser Glu Thr Ala Glu 
        595                 600                 605             


His Ile Ala Gln Gly Leu Arg Leu Tyr Arg Pro His Leu Ala Ser Glu 
    610                 615                 620                 


Lys Val Tyr Thr Ile Met Tyr Ser Cys Trp His Glu Lys Ala Asp Glu 
625                 630                 635                 640 


Arg Pro Thr Phe Lys Ile Leu Leu Ser Asn Ile Leu Asp Val Met Asp 
                645                 650                 655     


Glu Glu Ser 
            


<210>  259
<211>  267
<212>  PRT
<213>  Homo sapiens

<400>  259

Met His Tyr Ile Lys Thr Trp Ser Leu Leu Gly Glu Met Ser Glu Lys 
1               5                   10                  15      


Leu Arg Arg Cys Arg Lys Glu Leu Thr Ala Ala Ile Asp Arg Ala Phe 
            20                  25                  30          


Glu Gly Val Ser Tyr Ser Gln Glu Cys Thr Gly Gln Gln Arg Leu Glu 
        35                  40                  45              


Leu Ser Ala Ala Pro Leu Ser Phe Ser Leu Pro Val His Arg Leu Leu 
    50                  55                  60                  


Cys Arg Arg His Pro Leu Ala Ala Cys Ser Ser Ala Ala Pro Phe Ala 
65                  70                  75                  80  


Ala Val Pro Cys Ala Pro Glu Asn Glu Asn Pro Ala Phe Ala Thr Asn 
                85                  90                  95      


His Ala Pro Val Asn Ala Lys Pro His Ala Leu Cys Pro Glu Arg Lys 
            100                 105                 110         


Pro Leu Thr Ser Lys Glu Asn Val Leu Met His Ser Ser Ile Leu Ala 
        115                 120                 125             


Pro Glu Arg Glu Ser Trp Arg Thr Ala Gly Glu Gly Glu Asn Trp Arg 
    130                 135                 140                 


Lys Glu Asn Leu Arg Lys Asp Met Glu Arg Asp Leu Lys Ala Asp Ser 
145                 150                 155                 160 


Asn Met Pro Leu Asn Asn Ser Ser Gln Glu Val Thr Lys Asp Leu Leu 
                165                 170                 175     


Asp Met Ile Asp His Thr Ser Ile Arg Thr Ile Glu Glu Leu Ala Gly 
            180                 185                 190         


Lys Ile Glu Phe Glu Asn Glu Leu Asn His Met Cys Gly His Cys Gln 
        195                 200                 205             


Asp Ser Pro Phe Lys Glu Glu Ala Trp Ala Leu Leu Met Asp Lys Ser 
    210                 215                 220                 


Pro Gln Lys Ala Thr Asp Ala Asp Pro Gly Ser Leu Lys Gln Ala Phe 
225                 230                 235                 240 


Asp Asp His Asn Ile Val Glu Thr Val Leu Asp Leu Glu Glu Asp Tyr 
                245                 250                 255     


Asn Val Met Thr Ser Phe Lys Tyr Gln Ile Glu 
            260                 265         


<210>  260
<211>  1037
<212>  PRT
<213>  Homo sapiens

<400>  260

Met Arg Gly Ser Gly Pro Arg Gly Ala Gly Arg Arg Arg Pro Pro Ser 
1               5                   10                  15      


Gly Gly Gly Asp Thr Pro Ile Thr Pro Ala Ser Leu Ala Gly Cys Tyr 
            20                  25                  30          


Ser Ala Pro Arg Arg Ala Pro Leu Trp Thr Cys Leu Leu Leu Cys Ala 
        35                  40                  45              


Ala Leu Arg Thr Leu Leu Ala Ser Pro Ser Asn Glu Val Asn Leu Leu 
    50                  55                  60                  


Asp Ser Arg Thr Val Met Gly Asp Leu Gly Trp Ile Ala Phe Pro Lys 
65                  70                  75                  80  


Asn Gly Trp Glu Glu Ile Gly Glu Val Asp Glu Asn Tyr Ala Pro Ile 
                85                  90                  95      


His Thr Tyr Gln Val Cys Lys Val Met Glu Gln Asn Gln Asn Asn Trp 
            100                 105                 110         


Leu Leu Thr Ser Trp Ile Ser Asn Glu Gly Ala Ser Arg Ile Phe Ile 
        115                 120                 125             


Glu Leu Lys Phe Thr Leu Arg Asp Cys Asn Ser Leu Pro Gly Gly Leu 
    130                 135                 140                 


Gly Thr Cys Lys Glu Thr Phe Asn Met Tyr Tyr Phe Glu Ser Asp Asp 
145                 150                 155                 160 


Gln Asn Gly Arg Asn Ile Lys Glu Asn Gln Tyr Ile Lys Ile Asp Thr 
                165                 170                 175     


Ile Ala Ala Asp Glu Ser Phe Thr Glu Leu Asp Leu Gly Asp Arg Val 
            180                 185                 190         


Met Lys Leu Asn Thr Glu Val Arg Asp Val Gly Pro Leu Ser Lys Lys 
        195                 200                 205             


Gly Phe Tyr Leu Ala Phe Gln Asp Val Gly Ala Cys Ile Ala Leu Val 
    210                 215                 220                 


Ser Val Arg Val Tyr Tyr Lys Lys Cys Pro Ser Val Val Arg His Leu 
225                 230                 235                 240 


Ala Val Phe Pro Asp Thr Ile Thr Gly Ala Asp Ser Ser Gln Leu Leu 
                245                 250                 255     


Glu Val Ser Gly Ser Cys Val Asn His Ser Val Thr Asp Glu Pro Pro 
            260                 265                 270         


Lys Met His Cys Ser Ala Glu Gly Glu Trp Leu Val Pro Ile Gly Lys 
        275                 280                 285             


Cys Met Cys Lys Ala Gly Tyr Glu Glu Lys Asn Gly Thr Cys Gln Val 
    290                 295                 300                 


Cys Arg Pro Gly Phe Phe Lys Ala Ser Pro His Ile Gln Ser Cys Gly 
305                 310                 315                 320 


Lys Cys Pro Pro His Ser Tyr Thr His Glu Glu Ala Ser Thr Ser Cys 
                325                 330                 335     


Val Cys Glu Lys Asp Tyr Phe Arg Arg Glu Ser Asp Pro Pro Thr Met 
            340                 345                 350         


Ala Cys Thr Arg Pro Pro Ser Ala Pro Arg Asn Ala Ile Ser Asn Val 
        355                 360                 365             


Asn Glu Thr Ser Val Phe Leu Glu Trp Ile Pro Pro Ala Asp Thr Gly 
    370                 375                 380                 


Gly Arg Lys Asp Val Ser Tyr Tyr Ile Ala Cys Lys Lys Cys Asn Ser 
385                 390                 395                 400 


His Ala Gly Val Cys Glu Glu Cys Gly Gly His Val Arg Tyr Leu Pro 
                405                 410                 415     


Arg Gln Ser Gly Leu Lys Asn Thr Ser Val Met Met Val Asp Leu Leu 
            420                 425                 430         


Ala His Thr Asn Tyr Thr Phe Glu Ile Glu Ala Val Asn Gly Val Ser 
        435                 440                 445             


Asp Leu Ser Pro Gly Ala Arg Gln Tyr Val Ser Val Asn Val Thr Thr 
    450                 455                 460                 


Asn Gln Ala Ala Pro Ser Pro Val Thr Asn Val Lys Lys Gly Lys Ile 
465                 470                 475                 480 


Ala Lys Asn Ser Ile Ser Leu Ser Trp Gln Glu Pro Asp Arg Pro Asn 
                485                 490                 495     


Gly Ile Ile Leu Glu Tyr Glu Ile Lys Tyr Phe Glu Lys Asp Gln Glu 
            500                 505                 510         


Thr Ser Tyr Thr Ile Ile Lys Ser Lys Glu Thr Thr Ile Thr Ala Glu 
        515                 520                 525             


Gly Leu Lys Pro Ala Ser Val Tyr Val Phe Gln Ile Arg Ala Arg Thr 
    530                 535                 540                 


Ala Ala Gly Tyr Gly Val Phe Ser Arg Arg Phe Glu Phe Glu Thr Thr 
545                 550                 555                 560 


Pro Val Phe Ala Ala Ser Ser Asp Gln Ser Gln Ile Pro Val Ile Ala 
                565                 570                 575     


Val Ser Val Thr Val Gly Val Ile Leu Leu Ala Val Val Ile Gly Val 
            580                 585                 590         


Leu Leu Ser Gly Ser Cys Cys Glu Cys Gly Cys Gly Arg Ala Ser Ser 
        595                 600                 605             


Leu Cys Ala Val Ala His Pro Ser Leu Ile Trp Arg Cys Gly Tyr Ser 
    610                 615                 620                 


Lys Ala Lys Gln Asp Pro Glu Glu Glu Lys Met His Phe His Asn Gly 
625                 630                 635                 640 


His Ile Lys Leu Pro Gly Val Arg Thr Tyr Ile Asp Pro His Thr Tyr 
                645                 650                 655     


Glu Asp Pro Asn Gln Ala Val His Glu Phe Ala Lys Glu Ile Glu Ala 
            660                 665                 670         


Ser Cys Ile Thr Ile Glu Arg Val Ile Gly Ala Gly Glu Phe Gly Glu 
        675                 680                 685             


Val Cys Ser Gly Arg Leu Lys Leu Pro Gly Lys Arg Glu Leu Pro Val 
    690                 695                 700                 


Ala Ile Lys Thr Leu Lys Val Gly Tyr Thr Glu Lys Gln Arg Arg Asp 
705                 710                 715                 720 


Phe Leu Gly Glu Ala Ser Ile Met Gly Gln Phe Asp His Pro Asn Ile 
                725                 730                 735     


Ile His Leu Glu Gly Val Val Thr Lys Ser Lys Pro Val Met Ile Val 
            740                 745                 750         


Thr Glu Tyr Met Glu Asn Gly Ser Leu Asp Thr Phe Leu Lys Lys Asn 
        755                 760                 765             


Asp Gly Gln Phe Thr Val Ile Gln Leu Val Gly Met Leu Arg Gly Ile 
    770                 775                 780                 


Ser Ala Gly Met Lys Tyr Leu Ser Asp Met Gly Tyr Val His Arg Asp 
785                 790                 795                 800 


Leu Ala Ala Arg Asn Ile Leu Ile Asn Ser Asn Leu Val Cys Lys Val 
                805                 810                 815     


Ser Asp Phe Gly Leu Ser Arg Val Leu Glu Asp Asp Pro Glu Ala Ala 
            820                 825                 830         


Tyr Thr Thr Arg Gly Gly Lys Ile Pro Ile Arg Trp Thr Ala Pro Glu 
        835                 840                 845             


Ala Ile Ala Phe Arg Lys Phe Thr Ser Ala Ser Asp Val Trp Ser Tyr 
    850                 855                 860                 


Gly Ile Val Met Trp Glu Val Val Ser Tyr Gly Glu Arg Pro Tyr Trp 
865                 870                 875                 880 


Glu Met Thr Asn Gln Asp Val Ile Lys Ala Val Glu Glu Gly Tyr Arg 
                885                 890                 895     


Leu Pro Ser Pro Met Asp Cys Pro Ala Ala Leu Tyr Gln Leu Met Leu 
            900                 905                 910         


Asp Cys Trp Gln Lys Glu Arg Asn Ser Arg Pro Lys Phe Asp Glu Ile 
        915                 920                 925             


Val Asn Met Leu Asp Lys Leu Ile Arg Asn Pro Ser Ser Leu Lys Thr 
    930                 935                 940                 


Leu Val Asn Ala Ser Cys Arg Val Ser Asn Leu Leu Ala Glu His Ser 
945                 950                 955                 960 


Pro Leu Gly Ser Gly Ala Tyr Arg Ser Val Gly Glu Trp Leu Glu Ala 
                965                 970                 975     


Ile Lys Met Gly Arg Tyr Thr Glu Ile Phe Met Glu Asn Gly Tyr Ser 
            980                 985                 990         


Ser Met Asp Ala Val Ala Gln Val  Thr Leu Glu Asp Leu  Arg Arg Leu 
        995                 1000                 1005             


Gly Val  Thr Leu Val Gly His  Gln Lys Lys Ile Met  Asn Ser Leu 
    1010                 1015                 1020             


Gln Glu  Met Lys Val Gln Leu  Val Asn Gly Met Val  Pro Leu 
    1025                 1030                 1035         


<210>  261
<211>  1322
<212>  PRT
<213>  Homo sapiens

<400>  261

Met Pro Val Val Trp Pro Thr Leu Leu Asp Leu Ser Arg Asp Glu Cys 
1               5                   10                  15      


Lys Arg Ile Leu Arg Lys Leu Glu Leu Glu Ala Tyr Ala Gly Val Ile 
            20                  25                  30          


Ser Ala Leu Arg Ala Gln Gly Asp Leu Thr Lys Glu Lys Lys Asp Leu 
        35                  40                  45              


Leu Gly Glu Leu Ser Lys Val Leu Ser Ile Ser Thr Glu Arg His Arg 
    50                  55                  60                  


Ala Glu Val Arg Arg Ala Val Asn Asp Glu Arg Leu Thr Thr Ile Ala 
65                  70                  75                  80  


His Asn Met Ser Gly Pro Asn Ser Ser Ser Glu Trp Ser Ile Glu Gly 
                85                  90                  95      


Arg Arg Leu Val Pro Leu Met Pro Arg Leu Val Pro Gln Thr Ala Phe 
            100                 105                 110         


Thr Val Thr Ala Asn Ala Val Ala Asn Ala Ala Ile Gln His Asn Ala 
        115                 120                 125             


Ser Leu Pro Val Pro Ala Glu Thr Gly Ser Lys Glu Val Val Cys Tyr 
    130                 135                 140                 


Ser Tyr Thr Ser Thr Thr Ser Thr Pro Thr Ser Thr Pro Val Pro Ser 
145                 150                 155                 160 


Gly Ser Ile Ala Thr Val Lys Ser Pro Arg Pro Ala Ser Pro Ala Ser 
                165                 170                 175     


Asn Val Val Val Leu Pro Ser Gly Ser Thr Val Tyr Val Lys Ser Val 
            180                 185                 190         


Ser Cys Ser Asp Glu Asp Glu Lys Pro Arg Lys Arg Arg Arg Thr Asn 
        195                 200                 205             


Ser Ser Ser Ser Ser Pro Val Val Leu Lys Glu Val Pro Lys Ala Val 
    210                 215                 220                 


Val Pro Val Ser Lys Thr Ile Thr Val Pro Val Ser Gly Ser Pro Lys 
225                 230                 235                 240 


Met Ser Asn Ile Met Gln Ser Ile Ala Asn Ser Leu Pro Pro His Met 
                245                 250                 255     


Ser Pro Val Lys Ile Thr Phe Thr Lys Pro Ser Thr Gln Thr Thr Asn 
            260                 265                 270         


Thr Thr Thr Gln Lys Val Ile Ile Val Thr Thr Ser Pro Ser Ser Thr 
        275                 280                 285             


Phe Val Pro Asn Ile Leu Ser Lys Ser His Asn Tyr Ala Ala Val Thr 
    290                 295                 300                 


Lys Leu Val Pro Thr Ser Val Ile Ala Ser Thr Thr Gln Lys Pro Pro 
305                 310                 315                 320 


Val Val Ile Thr Ala Ser Gln Ser Ser Leu Val Ser Asn Ser Ser Ser 
                325                 330                 335     


Gly Ser Ser Ser Ser Thr Pro Ser Pro Ile Pro Asn Thr Val Ala Val 
            340                 345                 350         


Thr Ala Val Val Ser Ser Thr Pro Ser Val Val Met Ser Thr Val Ala 
        355                 360                 365             


Gln Gly Val Ser Thr Ser Ala Ile Lys Met Ala Ser Thr Arg Leu Pro 
    370                 375                 380                 


Ser Pro Lys Ser Leu Val Ser Ala Pro Thr Gln Ile Leu Ala Gln Phe 
385                 390                 395                 400 


Pro Lys Gln His Gln Gln Ser Pro Lys Gln Gln Leu Tyr Gln Val Gln 
                405                 410                 415     


Gln Gln Thr Gln Gln Gln Val Ala Gln Pro Ser Pro Val Ser His Gln 
            420                 425                 430         


Gln Gln Pro Gln Gln Ser Pro Leu Pro Pro Gly Ile Lys Pro Thr Ile 
        435                 440                 445             


Gln Ile Lys Gln Glu Ser Gly Val Lys Ile Ile Thr Gln Gln Val Gln 
    450                 455                 460                 


Pro Ser Lys Ile Leu Pro Lys Pro Val Thr Ala Thr Leu Pro Thr Ser 
465                 470                 475                 480 


Ser Asn Ser Pro Ile Met Val Val Ser Ser Asn Gly Ala Ile Met Thr 
                485                 490                 495     


Thr Lys Leu Val Thr Thr Pro Thr Gly Thr Gln Ala Thr Tyr Thr Arg 
            500                 505                 510         


Pro Thr Val Ser Pro Ser Ile Gly Arg Met Ala Ala Thr Pro Gly Ala 
        515                 520                 525             


Ala Thr Tyr Val Lys Thr Thr Ser Gly Ser Ile Ile Thr Val Val Pro 
    530                 535                 540                 


Lys Ser Leu Ala Thr Leu Gly Gly Lys Ile Ile Ser Ser Asn Ile Val 
545                 550                 555                 560 


Ser Gly Thr Thr Thr Lys Ile Thr Thr Ile Pro Met Thr Ser Lys Pro 
                565                 570                 575     


Asn Val Ile Val Val Gln Lys Thr Thr Gly Lys Gly Thr Thr Ile Gln 
            580                 585                 590         


Gly Leu Pro Gly Lys Asn Val Val Thr Thr Leu Leu Asn Ala Gly Gly 
        595                 600                 605             


Glu Lys Thr Ile Gln Thr Val Pro Thr Gly Ala Lys Pro Ala Ile Leu 
    610                 615                 620                 


Thr Ala Thr Arg Pro Ile Thr Lys Met Ile Val Thr Gln Pro Lys Gly 
625                 630                 635                 640 


Ile Gly Ser Thr Val Gln Pro Ala Ala Lys Ile Ile Pro Thr Lys Ile 
                645                 650                 655     


Val Tyr Gly Gln Gln Gly Lys Thr Gln Val Leu Ile Lys Pro Lys Pro 
            660                 665                 670         


Val Thr Phe Gln Ala Thr Val Val Ser Glu Gln Thr Arg Gln Leu Val 
        675                 680                 685             


Thr Glu Thr Leu Gln Gln Ala Ser Arg Val Ala Glu Ala Gly Asn Ser 
    690                 695                 700                 


Ser Ile Gln Glu Gly Lys Glu Glu Pro Gln Asn Tyr Thr Asp Ser Ser 
705                 710                 715                 720 


Ser Ser Ser Thr Glu Ser Ser Gln Ser Ser Gln Asp Ser Gln Pro Val 
                725                 730                 735     


Val His Val Ile Ala Ser Arg Arg Gln Asp Trp Ser Glu His Glu Ile 
            740                 745                 750         


Ala Met Glu Thr Ser Pro Thr Ile Ile Tyr Gln Asp Val Ser Ser Glu 
        755                 760                 765             


Ser Gln Ser Ala Thr Ser Thr Ile Lys Ala Leu Leu Glu Leu Gln Gln 
    770                 775                 780                 


Thr Thr Val Lys Glu Lys Leu Glu Ser Lys Pro Arg Gln Pro Thr Ile 
785                 790                 795                 800 


Asp Leu Ser Gln Met Ala Val Pro Ile Gln Met Thr Gln Glu Lys Arg 
                805                 810                 815     


His Ser Pro Glu Ser Pro Ser Ile Ala Val Val Glu Ser Glu Leu Val 
            820                 825                 830         


Ala Glu Tyr Ile Thr Thr Glu Arg Thr Asp Glu Gly Thr Glu Val Ala 
        835                 840                 845             


Phe Pro Leu Leu Val Ser His Arg Ser Gln Pro Gln Gln Pro Ser Gln 
    850                 855                 860                 


Pro Gln Arg Thr Leu Leu Gln His Val Ala Gln Ser Gln Thr Ala Thr 
865                 870                 875                 880 


Gln Thr Ser Val Val Val Lys Ser Ile Pro Ala Ser Ser Pro Gly Ala 
                885                 890                 895     


Ile Thr His Ile Met Gln Gln Ala Leu Ser Ser His Thr Ala Phe Thr 
            900                 905                 910         


Lys His Ser Glu Glu Leu Gly Thr Glu Glu Gly Glu Val Glu Glu Met 
        915                 920                 925             


Asp Thr Leu Asp Pro Gln Thr Gly Leu Phe Tyr Arg Ser Ala Leu Thr 
    930                 935                 940                 


Gln Ser Gln Ser Ala Lys Gln Gln Lys Leu Ser Gln Pro Pro Leu Glu 
945                 950                 955                 960 


Gln Thr Gln Leu Gln Val Lys Thr Leu Gln Cys Phe Gln Thr Lys Gln 
                965                 970                 975     


Lys Gln Thr Ile His Leu Gln Ala Asp Gln Leu Gln His Lys Leu Pro 
            980                 985                 990         


Gln Met Pro Gln Leu Ser Ile Arg  His Gln Lys Leu Thr  Pro Leu Gln 
        995                 1000                 1005             


Gln Glu  Gln Ala Gln Pro Lys  Pro Asp Val Gln His  Thr Gln His 
    1010                 1015                 1020             


Pro Met  Val Ala Lys Asp Arg  Gln Leu Pro Thr Leu  Met Ala Gln 
    1025                 1030                 1035             


Pro Pro  Gln Thr Val Val Gln  Val Leu Ala Val Lys  Thr Thr Gln 
    1040                 1045                 1050             


Gln Leu  Pro Lys Leu Gln Gln  Ala Pro Asn Gln Pro  Lys Ile Tyr 
    1055                 1060                 1065             


Val Gln  Pro Gln Thr Pro Gln  Ser Gln Met Ser Leu  Pro Ala Ser 
    1070                 1075                 1080             


Ser Glu  Lys Gln Thr Ala Ser  Gln Val Glu Gln Pro  Ile Ile Thr 
    1085                 1090                 1095             


Gln Gly  Ser Ser Val Thr Lys  Ile Thr Phe Glu Gly  Arg Gln Pro 
    1100                 1105                 1110             


Pro Thr  Val Thr Lys Ile Thr  Gly Gly Ser Ser Val  Pro Lys Leu 
    1115                 1120                 1125             


Thr Ser  Pro Val Thr Ser Ile  Ser Pro Ile Gln Ala  Ser Glu Lys 
    1130                 1135                 1140             


Thr Ala  Val Ser Asp Ile Leu  Lys Met Ser Leu Met  Glu Ala Gln 
    1145                 1150                 1155             


Ile Asp  Thr Asn Val Glu His  Met Ile Val Asp Pro  Pro Lys Lys 
    1160                 1165                 1170             


Ala Leu  Ala Thr Ser Met Leu  Thr Gly Glu Ala Gly  Ser Leu Pro 
    1175                 1180                 1185             


Ser Thr  His Met Val Val Ala  Gly Met Ala Asn Ser  Thr Pro Gln 
    1190                 1195                 1200             


Gln Gln  Lys Cys Arg Glu Ser  Cys Ser Ser Pro Ser  Thr Val Gly 
    1205                 1210                 1215             


Ser Ser  Leu Thr Thr Arg Lys  Ile Asp Pro Pro Ala  Val Pro Ala 
    1220                 1225                 1230             


Thr Gly  Gln Phe Met Arg Ile  Gln Asn Val Gly Gln  Lys Lys Ala 
    1235                 1240                 1245             


Glu Glu  Ser Pro Ala Glu Ile  Ile Ile Gln Ala Ile  Pro Gln Tyr 
    1250                 1255                 1260             


Ala Ile  Pro Cys His Ser Ser  Ser Asn Val Val Val  Glu Pro Ser 
    1265                 1270                 1275             


Gly Leu  Leu Glu Leu Asn Asn  Phe Thr Ser Gln Gln  Leu Asp Asp 
    1280                 1285                 1290             


Glu Glu  Thr Ala Met Glu Gln  Asp Ile Asp Ser Ser  Thr Glu Asp 
    1295                 1300                 1305             


Gly Thr  Glu Pro Ser Pro Ser  Gln Ser Ser Ala Glu  Arg Ser 
    1310                 1315                 1320         


<210>  262
<211>  502
<212>  PRT
<213>  Homo sapiens

<400>  262

Met Ala Ala Pro Cys Glu Gly Gln Ala Phe Ala Val Gly Val Glu Lys 
1               5                   10                  15      


Asn Trp Gly Ala Val Val Arg Ser Pro Glu Gly Thr Pro Gln Lys Ile 
            20                  25                  30          


Arg Gln Leu Ile Asp Glu Gly Ile Ala Pro Glu Glu Gly Gly Val Asp 
        35                  40                  45              


Ala Lys Asp Thr Ser Ala Thr Ser Gln Ser Val Asn Gly Ser Pro Gln 
    50                  55                  60                  


Ala Glu Gln Pro Ser Leu Glu Ser Thr Ser Lys Glu Ala Phe Phe Ser 
65                  70                  75                  80  


Arg Val Glu Thr Phe Ser Ser Leu Lys Trp Ala Gly Lys Pro Phe Glu 
                85                  90                  95      


Leu Ser Pro Leu Val Cys Ala Lys Tyr Gly Trp Val Thr Val Glu Cys 
            100                 105                 110         


Asp Met Leu Lys Cys Ser Ser Cys Gln Ala Phe Leu Cys Ala Ser Leu 
        115                 120                 125             


Gln Pro Ala Phe Asp Phe Asp Arg Tyr Lys Gln Arg Cys Ala Glu Leu 
    130                 135                 140                 


Lys Lys Ala Leu Cys Thr Ala His Glu Lys Phe Cys Phe Trp Pro Asp 
145                 150                 155                 160 


Ser Pro Ser Pro Asp Arg Phe Gly Met Leu Pro Leu Asp Glu Pro Ala 
                165                 170                 175     


Ile Leu Val Ser Glu Phe Leu Asp Arg Phe Gln Ser Leu Cys His Leu 
            180                 185                 190         


Asp Leu Gln Leu Pro Ser Leu Arg Pro Glu Asp Leu Lys Thr Met Cys 
        195                 200                 205             


Leu Thr Glu Asp Lys Ile Ser Leu Leu Leu His Leu Leu Glu Asp Glu 
    210                 215                 220                 


Leu Asp His Arg Thr Asp Glu Arg Lys Thr Thr Ile Lys Leu Gly Ser 
225                 230                 235                 240 


Asp Ile Gln Val His Val Thr Ala Cys Ile Leu Ser Val Cys Gly Trp 
                245                 250                 255     


Ala Cys Ser Ser Ser Leu Glu Ser Met Gln Leu Ser Leu Ile Thr Cys 
            260                 265                 270         


Ser Gln Cys Met Arg Lys Val Gly Leu Trp Gly Phe Gln Gln Ile Glu 
        275                 280                 285             


Ser Ser Met Thr Asp Leu Asp Ala Ser Phe Gly Leu Thr Ser Ser Pro 
    290                 295                 300                 


Ile Pro Gly Leu Glu Gly Arg Pro Glu Arg Leu Pro Leu Val Pro Glu 
305                 310                 315                 320 


Ser Pro Arg Arg Met Met Thr Arg Ser Gln Asp Ala Thr Phe Ser Pro 
                325                 330                 335     


Gly Ser Glu Gln Ala Glu Lys Ser Pro Gly Pro Ile Val Ser Arg Thr 
            340                 345                 350         


Arg Ser Trp Asp Ser Ser Ser Pro Val Asp Arg Pro Glu Pro Glu Ala 
        355                 360                 365             


Ala Ser Pro Thr Thr Arg Thr Arg Pro Val Thr Arg Ser Met Gly Thr 
    370                 375                 380                 


Gly Asp Thr Pro Gly Leu Glu Val Pro Ser Ser Pro Leu Arg Lys Ala 
385                 390                 395                 400 


Lys Arg Ala Arg Leu Cys Ser Ser Ser Ser Ser Asp Thr Ser Ser Arg 
                405                 410                 415     


Ser Phe Phe Asp Pro Thr Ser Gln His Arg Asp Trp Cys Pro Trp Val 
            420                 425                 430         


Asn Ile Thr Leu Gly Lys Glu Ser Arg Glu Asn Gly Gly Thr Glu Pro 
        435                 440                 445             


Asp Ala Ser Ala Pro Ala Glu Pro Gly Trp Lys Ala Val Leu Thr Ile 
    450                 455                 460                 


Leu Leu Ala His Lys Gln Ser Ser Gln Pro Ala Glu Thr Asp Ser Met 
465                 470                 475                 480 


Ser Leu Ser Glu Lys Ser Arg Lys Val Phe Arg Ile Phe Arg Gln Trp 
                485                 490                 495     


Glu Ser Leu Cys Ser Cys 
            500         


<210>  263
<211>  525
<212>  PRT
<213>  Homo sapiens

<400>  263

Met Arg Arg Arg Arg Arg Arg Asp Gly Phe Tyr Pro Ala Pro Asp Phe 
1               5                   10                  15      


Arg Asp Arg Glu Ala Glu Asp Met Ala Gly Val Phe Asp Ile Asp Leu 
            20                  25                  30          


Asp Gln Pro Glu Asp Ala Gly Ser Glu Asp Glu Leu Glu Glu Gly Gly 
        35                  40                  45              


Gln Leu Asn Glu Ser Met Asp His Gly Gly Val Gly Pro Tyr Glu Leu 
    50                  55                  60                  


Gly Met Glu His Cys Glu Lys Phe Glu Ile Ser Glu Thr Ser Val Asn 
65                  70                  75                  80  


Arg Gly Pro Glu Lys Ile Arg Pro Glu Cys Phe Glu Leu Leu Arg Val 
                85                  90                  95      


Leu Gly Lys Gly Gly Tyr Gly Lys Val Phe Gln Val Arg Lys Val Thr 
            100                 105                 110         


Gly Ala Asn Thr Gly Lys Ile Phe Ala Met Lys Val Leu Lys Lys Ala 
        115                 120                 125             


Met Ile Val Arg Asn Ala Lys Asp Thr Ala His Thr Lys Ala Glu Arg 
    130                 135                 140                 


Asn Ile Leu Glu Glu Val Lys His Pro Phe Ile Val Asp Leu Ile Tyr 
145                 150                 155                 160 


Ala Phe Gln Thr Gly Gly Lys Leu Tyr Leu Ile Leu Glu Tyr Leu Ser 
                165                 170                 175     


Gly Gly Glu Leu Phe Met Gln Leu Glu Arg Glu Gly Ile Phe Met Glu 
            180                 185                 190         


Asp Thr Ala Cys Phe Tyr Leu Ala Glu Ile Ser Met Ala Leu Gly His 
        195                 200                 205             


Leu His Gln Lys Gly Ile Ile Tyr Arg Asp Leu Lys Pro Glu Asn Ile 
    210                 215                 220                 


Met Leu Asn His Gln Gly His Val Lys Leu Thr Asp Phe Gly Leu Cys 
225                 230                 235                 240 


Lys Glu Ser Ile His Asp Gly Thr Val Thr His Thr Phe Cys Gly Thr 
                245                 250                 255     


Ile Glu Tyr Met Ala Pro Glu Ile Leu Met Arg Ser Gly His Asn Arg 
            260                 265                 270         


Ala Val Asp Trp Trp Ser Leu Gly Ala Leu Met Tyr Asp Met Leu Thr 
        275                 280                 285             


Gly Ala Pro Pro Phe Thr Gly Glu Asn Arg Lys Lys Thr Ile Asp Lys 
    290                 295                 300                 


Ile Leu Lys Cys Lys Leu Asn Leu Pro Pro Tyr Leu Thr Gln Glu Ala 
305                 310                 315                 320 


Arg Asp Leu Leu Lys Lys Leu Leu Lys Arg Asn Ala Ala Ser Arg Leu 
                325                 330                 335     


Gly Ala Gly Pro Gly Asp Ala Gly Glu Val Gln Ala His Pro Phe Phe 
            340                 345                 350         


Arg His Ile Asn Trp Glu Glu Leu Leu Ala Arg Lys Val Glu Pro Pro 
        355                 360                 365             


Phe Lys Pro Leu Leu Gln Ser Glu Glu Asp Val Ser Gln Phe Asp Ser 
    370                 375                 380                 


Lys Phe Thr Arg Gln Thr Pro Val Asp Ser Pro Asp Asp Ser Thr Leu 
385                 390                 395                 400 


Ser Glu Ser Ala Asn Gln Val Phe Leu Gly Phe Thr Tyr Val Ala Pro 
                405                 410                 415     


Ser Val Leu Glu Ser Val Lys Glu Lys Phe Ser Phe Glu Pro Lys Ile 
            420                 425                 430         


Arg Ser Pro Arg Arg Phe Ile Gly Ser Pro Arg Thr Pro Val Ser Pro 
        435                 440                 445             


Val Lys Phe Ser Pro Gly Asp Phe Trp Gly Arg Gly Ala Ser Ala Ser 
    450                 455                 460                 


Thr Ala Asn Pro Gln Thr Pro Val Glu Tyr Pro Met Glu Thr Ser Gly 
465                 470                 475                 480 


Ile Glu Gln Met Asp Val Thr Met Ser Gly Glu Ala Ser Ala Pro Leu 
                485                 490                 495     


Pro Ile Arg Gln Pro Asn Ser Gly Pro Tyr Lys Lys Gln Ala Phe Pro 
            500                 505                 510         


Met Ile Ser Lys Arg Pro Glu His Leu Arg Met Asn Leu 
        515                 520                 525 


<210>  264
<211>  646
<212>  PRT
<213>  Homo sapiens

<400>  264

Met Ala Ala Glu Ser Gly Ser Asp Phe Gln Gln Arg Arg Arg Arg Arg 
1               5                   10                  15      


Arg Asp Pro Glu Glu Pro Glu Lys Thr Glu Leu Ser Glu Arg Glu Leu 
            20                  25                  30          


Ala Val Ala Val Ala Val Ser Gln Glu Asn Asp Glu Glu Asn Glu Glu 
        35                  40                  45              


Arg Trp Val Gly Pro Leu Pro Val Glu Ala Thr Leu Ala Lys Lys Arg 
    50                  55                  60                  


Lys Val Leu Glu Phe Glu Arg Val Tyr Leu Asp Asn Leu Pro Ser Ala 
65                  70                  75                  80  


Ser Met Tyr Glu Arg Ser Tyr Met His Arg Asp Val Ile Thr His Val 
                85                  90                  95      


Val Cys Thr Lys Thr Asp Phe Ile Ile Thr Ala Ser His Asp Gly His 
            100                 105                 110         


Val Lys Phe Trp Lys Lys Ile Glu Glu Gly Ile Glu Phe Val Lys His 
        115                 120                 125             


Phe Arg Ser His Leu Gly Val Ile Glu Ser Ile Ala Val Ser Ser Glu 
    130                 135                 140                 


Gly Ala Leu Phe Cys Ser Val Gly Asp Asp Lys Ala Met Lys Val Phe 
145                 150                 155                 160 


Asp Val Val Asn Phe Asp Met Ile Asn Met Leu Lys Leu Gly Tyr Phe 
                165                 170                 175     


Pro Gly Gln Cys Glu Trp Ile Tyr Cys Pro Gly Asp Ala Ile Ser Ser 
            180                 185                 190         


Val Ala Ala Ser Glu Lys Ser Thr Gly Lys Ile Phe Ile Tyr Asp Gly 
        195                 200                 205             


Arg Gly Asp Asn Gln Pro Leu His Ile Phe Asp Lys Leu His Thr Ser 
    210                 215                 220                 


Pro Leu Thr Gln Ile Arg Leu Asn Pro Val Tyr Lys Ala Val Val Ser 
225                 230                 235                 240 


Ser Asp Lys Ser Gly Met Ile Glu Tyr Trp Thr Gly Pro Pro His Glu 
                245                 250                 255     


Tyr Lys Phe Pro Lys Asn Val Asn Trp Glu Tyr Lys Thr Asp Thr Asp 
            260                 265                 270         


Leu Tyr Glu Phe Ala Lys Cys Lys Ala Tyr Pro Thr Ser Val Cys Phe 
        275                 280                 285             


Ser Pro Asp Gly Lys Lys Ile Ala Thr Ile Gly Ser Asp Arg Lys Val 
    290                 295                 300                 


Arg Ile Phe Arg Phe Val Thr Gly Lys Leu Met Arg Val Phe Asp Glu 
305                 310                 315                 320 


Ser Leu Ser Met Phe Thr Glu Leu Gln Gln Met Arg Gln Gln Leu Pro 
                325                 330                 335     


Asp Met Glu Phe Gly Arg Arg Met Ala Val Glu Arg Glu Leu Glu Lys 
            340                 345                 350         


Val Asp Ala Val Arg Leu Ile Asn Ile Val Phe Asp Glu Thr Gly His 
        355                 360                 365             


Phe Val Leu Tyr Gly Thr Met Leu Gly Ile Lys Val Ile Asn Val Glu 
    370                 375                 380                 


Thr Asn Arg Cys Val Arg Ile Leu Gly Lys Gln Glu Asn Ile Arg Val 
385                 390                 395                 400 


Met Gln Leu Ala Leu Phe Gln Gly Ile Ala Lys Lys His Arg Ala Ala 
                405                 410                 415     


Thr Thr Ile Glu Met Lys Ala Ser Glu Asn Pro Val Leu Gln Asn Ile 
            420                 425                 430         


Gln Ala Asp Pro Thr Ile Val Cys Thr Ser Phe Lys Lys Asn Arg Phe 
        435                 440                 445             


Tyr Met Phe Thr Lys Arg Glu Pro Glu Asp Thr Lys Ser Ala Asp Ser 
    450                 455                 460                 


Asp Arg Asp Val Phe Asn Glu Lys Pro Ser Lys Glu Glu Val Met Ala 
465                 470                 475                 480 


Ala Thr Gln Ala Glu Gly Pro Lys Arg Val Ser Asp Ser Ala Ile Ile 
                485                 490                 495     


His Thr Ser Met Gly Asp Ile His Thr Lys Leu Phe Pro Val Glu Cys 
            500                 505                 510         


Pro Lys Thr Val Glu Asn Phe Cys Val His Ser Arg Asn Gly Tyr Tyr 
        515                 520                 525             


Asn Gly His Thr Phe His Arg Ile Ile Lys Gly Phe Met Ile Gln Thr 
    530                 535                 540                 


Gly Asp Pro Thr Gly Thr Gly Met Gly Gly Glu Ser Ile Trp Gly Gly 
545                 550                 555                 560 


Glu Phe Glu Asp Glu Phe His Ser Thr Leu Arg His Asp Arg Pro Tyr 
                565                 570                 575     


Thr Leu Ser Met Ala Asn Ala Gly Ser Asn Thr Asn Gly Ser Gln Phe 
            580                 585                 590         


Phe Ile Thr Val Val Pro Thr Pro Trp Leu Asp Asn Lys His Thr Val 
        595                 600                 605             


Phe Gly Arg Val Thr Lys Gly Met Glu Val Val Gln Arg Ile Ser Asn 
    610                 615                 620                 


Val Lys Val Asn Pro Lys Thr Asp Lys Pro Tyr Glu Asp Val Ser Ile 
625                 630                 635                 640 


Ile Asn Ile Thr Val Lys 
                645     


<210>  265
<211>  778
<212>  PRT
<213>  Homo sapiens

<400>  265

Met Ser Lys Arg Lys Leu Ile Pro Lys Leu Ser Ile Gln Ser Pro Val 
1               5                   10                  15      


Leu His Thr Asn Leu Asn Val Gln Ser Thr His Pro Pro Leu Lys Lys 
            20                  25                  30          


Glu Asp Leu His Arg Ile Ser Lys Asp Ser Leu Glu Ser Asp Ser Glu 
        35                  40                  45              


Ser Leu Thr Gln Glu Ile Met Cys His Ser Glu Phe Asp Asp Arg Ile 
    50                  55                  60                  


Arg Gly Asn Gly Met Glu Pro Asp Ser Leu Asp Glu Glu Glu Ser Pro 
65                  70                  75                  80  


Arg Trp Gly Ser Leu His Glu Met Glu Glu Glu Ala Ser Gly Lys Ala 
                85                  90                  95      


Ala Gln Met Ala Arg Glu Gln Asn His His Thr Trp Asp Gln Gly Ala 
            100                 105                 110         


Asn Asn Arg Gln Gln Pro Ile Glu Asp Lys Tyr Ser Asp Leu Arg Tyr 
        115                 120                 125             


Asp Pro Asn Trp Lys Ser Lys Lys Glu Glu Gly Gln Leu Leu Ser Val 
    130                 135                 140                 


Glu Ala Leu Pro Glu Ser Thr Asp Ser Ser Leu Glu Asn Leu Pro Leu 
145                 150                 155                 160 


Ala Pro Leu Tyr Pro Ser Gln Glu Thr Ser Met Glu Leu Ser Gly Gly 
                165                 170                 175     


Lys Gly Glu Gln Lys Glu Ser Pro Gln Ser Ala Ala Ser Leu Leu Gly 
            180                 185                 190         


Ser Glu Phe Leu Ser Pro Asn Tyr Glu His Gly Ala Arg Arg Ser Lys 
        195                 200                 205             


Pro Phe Ser Glu Leu Ser Asp Ser Asp Leu Glu Glu Lys Ser Ser Ser 
    210                 215                 220                 


Leu Ser Pro Tyr Val Lys Ser Ser Ser Ser His Asn Glu Val Phe Leu 
225                 230                 235                 240 


Pro Gly Ser Arg Gly Pro Arg Arg Arg Lys Ser Lys Gln His Phe Val 
                245                 250                 255     


Glu Lys Asn Lys Leu Thr Leu Gly Leu Pro Thr Pro Lys Thr Asp Ser 
            260                 265                 270         


Tyr Leu Gln Leu His Asn Lys Lys Arg Gly Glu Ser His Pro Glu Gln 
        275                 280                 285             


Ile Ser Tyr Pro Val Arg Val Thr Asp Lys Thr Ser Ile Gln Asn Ala 
    290                 295                 300                 


Lys Glu Met Glu Asn Ala Ala Ile Asp Pro Glu Asp Lys Trp His Gln 
305                 310                 315                 320 


Arg Ala Gln Gln Leu Lys Asn Tyr Gln Glu His Trp Ser Gln Tyr Glu 
                325                 330                 335     


Ser Thr Lys Ser Ser Asn Val Pro Arg Gly Gln Pro Ser Asp Met Val 
            340                 345                 350         


Asn Asp His Gln Pro Ser Arg Arg Pro Ala Lys Leu Lys Ile Arg Lys 
        355                 360                 365             


Gln Cys Lys His Gln Asn Gly Leu Lys Ser Ser Thr Thr Glu Glu Val 
    370                 375                 380                 


Thr Ala Ser Gln Gly Asn Gln Asn Asn Pro Pro Arg Gln Gln Gln Asn 
385                 390                 395                 400 


Gln Asn Lys Pro Leu Asp Thr Ser Thr Lys Pro Glu Ser Ile Val Ile 
                405                 410                 415     


Met His Ala Ser Asn Asn Asp Val Gln Ala Ser Arg Ala Leu Arg Ser 
            420                 425                 430         


His Asn Leu Lys Glu Thr Ser Asn Thr Phe Ala Pro Pro Lys Gln Ala 
        435                 440                 445             


Phe Asp Lys Val Leu Ser Lys Asn Ser Thr Gly Cys Asp Ser Gly Leu 
    450                 455                 460                 


Asn Val Asn Lys Glu Arg Gly His Lys Asp Gln Glu Glu Lys Arg Phe 
465                 470                 475                 480 


Ser Tyr Gln Gln Leu His Thr Leu Ser Asp Met Asp Leu Asn Asn Leu 
                485                 490                 495     


Asn Glu Leu Ser Lys Arg His Val Leu Leu Ser Gln Lys Gly Ser Gln 
            500                 505                 510         


Phe Val Tyr His Ile Asn Thr His Gly Ser Thr Lys Asn Lys Lys Gln 
        515                 520                 525             


Leu Lys Gln Pro Tyr Thr Glu Thr Lys Tyr Arg Asn Leu Glu Met Leu 
    530                 535                 540                 


Trp Lys Phe His Ser Ser Ser Asp Ser Gln Thr Val Arg Ala Ser Pro 
545                 550                 555                 560 


Asp Ser Trp Leu Thr Gln Ile Met Glu Gln His Gln Gln Ala Leu Val 
                565                 570                 575     


Gln Leu Thr Asp Val Gln Pro Ser Glu Gly Ala Leu Ser Ser Val Thr 
            580                 585                 590         


Leu Pro Pro Ile Leu Ser Arg Val Glu Ser Glu Ser Gln Leu Ser Ser 
        595                 600                 605             


Glu Arg Ser Gln Arg Asn Gln Val Lys Ile Ser Arg Ser Asn Ser Glu 
    610                 615                 620                 


Gly Tyr Leu Phe Gln Leu Glu Lys Gly Lys Lys His Lys Lys Arg Ser 
625                 630                 635                 640 


Ser Ser Lys Asn Thr Lys Leu Lys Gly Tyr Gln Lys Arg Asp Val Lys 
                645                 650                 655     


Leu Gly Gly Leu Gly Pro Asp Phe Glu Ser Ile Arg Asp Lys Thr Gln 
            660                 665                 670         


Lys Leu Ile Gln Gln Lys Glu Tyr Ala Lys Gln Val Lys Glu Tyr Asn 
        675                 680                 685             


Met Lys Thr Leu Ser Ile Leu Ser Lys Pro Gln Thr Glu Lys Thr Gln 
    690                 695                 700                 


Lys Lys Ser Ala Ile Pro Arg Gln Lys Ala Leu Glu Tyr Ala Lys Thr 
705                 710                 715                 720 


Ile Pro Lys Pro Lys Pro Ser Asn Leu Thr His Gln Ala Ser Lys Glu 
                725                 730                 735     


Gln Lys Asn Pro Thr Tyr Ala Gly Lys Glu Glu Ser Leu Pro Glu Ile 
            740                 745                 750         


Ser Leu Leu Glu Ile Leu Gln Asn Arg His Glu Arg Glu Lys Gln Ala 
        755                 760                 765             


Val Ala Ala Phe Lys Val Leu His Ile Val 
    770                 775             


<210>  266
<211>  280
<212>  PRT
<213>  Homo sapiens

<400>  266

Met Arg Arg Ala Glu Leu Ala Gly Leu Lys Thr Met Ala Trp Val Pro 
1               5                   10                  15      


Ala Glu Ser Ala Val Glu Glu Leu Met Pro Arg Leu Leu Pro Val Glu 
            20                  25                  30          


Pro Cys Asp Leu Thr Glu Gly Phe Asp Pro Ser Val Pro Pro Arg Thr 
        35                  40                  45              


Pro Gln Glu Tyr Leu Arg Arg Val Gln Ile Glu Ala Ala Gln Cys Pro 
    50                  55                  60                  


Asp Val Val Val Ala Gln Ile Asp Pro Lys Lys Leu Lys Arg Lys Gln 
65                  70                  75                  80  


Ser Val Asn Ile Ser Leu Ser Gly Cys Gln Pro Ala Pro Glu Gly Tyr 
                85                  90                  95      


Ser Pro Thr Leu Gln Trp Gln Gln Gln Gln Val Ala Gln Phe Ser Thr 
            100                 105                 110         


Val Arg Gln Asn Val Asn Lys His Arg Ser His Trp Lys Ser Gln Gln 
        115                 120                 125             


Leu Asp Ser Asn Val Thr Met Pro Lys Ser Glu Asp Glu Glu Gly Trp 
    130                 135                 140                 


Lys Lys Phe Cys Leu Gly Glu Lys Leu Cys Ala Asp Gly Ala Val Gly 
145                 150                 155                 160 


Pro Ala Thr Asn Glu Ser Pro Gly Ile Asp Tyr Val Gln Ile Gly Phe 
                165                 170                 175     


Pro Pro Leu Leu Ser Ile Val Ser Arg Met Asn Gln Ala Thr Val Thr 
            180                 185                 190         


Ser Val Leu Glu Tyr Leu Ser Asn Trp Phe Gly Glu Arg Asp Phe Thr 
        195                 200                 205             


Pro Glu Leu Gly Arg Trp Leu Tyr Ala Leu Leu Ala Cys Leu Glu Lys 
    210                 215                 220                 


Pro Leu Leu Pro Glu Ala His Ser Leu Ile Arg Gln Leu Ala Arg Arg 
225                 230                 235                 240 


Cys Ser Glu Val Arg Leu Leu Val Asp Ser Lys Asp Asp Glu Arg Val 
                245                 250                 255     


Pro Ala Leu Asn Leu Leu Ile Cys Leu Val Ser Arg Tyr Phe Asp Gln 
            260                 265                 270         


Arg Asp Leu Ala Asp Glu Pro Ser 
        275                 280 


<210>  267
<211>  756
<212>  PRT
<213>  Homo sapiens

<400>  267

Met Gly Lys Arg Gly Ser Arg Ser Gln Ser Gln Leu Leu Asn Thr Leu 
1               5                   10                  15      


Thr Lys Lys Gln Lys Lys His Leu Arg Asp Phe Gly Glu Glu His Pro 
            20                  25                  30          


Phe Tyr Asp Arg Val Ser Arg Lys Glu Ala Lys Pro Gln Ile Cys Gln 
        35                  40                  45              


Leu Ser Glu Ser Ser Asp Ser Ser Asp Ser Glu Ser Asp Ser Glu Ser 
    50                  55                  60                  


Glu Pro Gln Gln Val Ser Gly Tyr His Arg Leu Leu Ala Thr Leu Lys 
65                  70                  75                  80  


Asn Val Ser Glu Glu Glu Glu Glu Asp Glu Glu Glu Glu Glu Glu Glu 
                85                  90                  95      


Asp Ser Ile Val Asp Asp Ala Glu Met Asn Asp Glu Asp Gly Gly Ser 
            100                 105                 110         


Asp Val Ser Val Glu Glu Glu Met Ala Ala Glu Ser Thr Glu Ser Pro 
        115                 120                 125             


Glu Asn Val Ala Leu Ser Ala Asp Pro Glu Gly Lys Glu Asp Gly Glu 
    130                 135                 140                 


Glu Pro Pro Gly Thr Ser Gln Thr Ser Pro Glu Glu Phe Thr Asp Ala 
145                 150                 155                 160 


Lys His Glu Ser Leu Phe Ser Leu Glu Thr Asn Phe Leu Glu Glu Glu 
                165                 170                 175     


Ser Gly Asp Asn Ser Ser Leu Lys Ala Ser Gln Asp Pro Phe Leu Gln 
            180                 185                 190         


His Val Asn Lys Glu Leu Lys Glu Lys Ala Ile Gln Ala Val Ala Thr 
        195                 200                 205             


Asn Pro Lys Thr Thr His Glu Leu Lys Trp Pro Ile Leu Gly Gln Leu 
    210                 215                 220                 


Phe Phe Ser Ser Lys Phe Gln Lys Leu Glu Thr Phe Lys Pro Pro Lys 
225                 230                 235                 240 


Asp Ile Asp Leu Lys Ser Leu His Leu Gln Lys Pro Leu Glu Ser Thr 
                245                 250                 255     


Trp Thr Lys Thr Asn Ser Gln Phe Leu Ser Gly Pro Gln Lys Ser Ser 
            260                 265                 270         


Ser Pro Phe Thr Pro Leu Gln Lys Glu Leu Phe Leu Ile Met Asn Ser 
        275                 280                 285             


Tyr Arg Asp Leu Phe Tyr Pro Glu Arg Thr Ala Leu Lys Asn Gly Glu 
    290                 295                 300                 


Glu Ile Arg His Val Tyr Cys Leu His Val Ile Asn His Ile Leu Lys 
305                 310                 315                 320 


Ala Asn Ala Gln Val Leu Gly Asn Asn Ser Arg Arg Arg Ser Gln Lys 
                325                 330                 335     


Phe Gly Val Gly Asp Asp Asp Asp Phe Arg Asp Gln Gly Leu Thr Arg 
            340                 345                 350         


Pro Lys Val Leu Ile Val Val Pro Phe Arg Glu Ala Ala Leu Arg Val 
        355                 360                 365             


Val Gln Leu Phe Ile Ser Leu Leu Glu Gly Asp Ser Lys Lys Lys Ile 
    370                 375                 380                 


Ile Val Ser Asn Lys Lys Arg Phe Gln Gly Glu Tyr Gly Ser Asp Pro 
385                 390                 395                 400 


Glu Glu Arg Pro Pro Asn Leu Lys Arg Pro Glu Asp Tyr Glu Ala Val 
                405                 410                 415     


Phe Val Gly Asn Ile Asp Asp His Phe Arg Ile Gly Val Ala Ile Leu 
            420                 425                 430         


Gln Arg Ser Ile Arg Leu Tyr Ala Pro Phe Tyr Ser Ser Asp Ile Leu 
        435                 440                 445             


Ile Ala Ser Pro Leu Gly Leu Arg Thr Ile Ile Gly Gly Glu Gly Glu 
    450                 455                 460                 


Lys Lys Arg Asp Phe Asp Phe Leu Ser Ser Ile Glu Leu Leu Ile Ile 
465                 470                 475                 480 


Asp Gln Ala Asp Ile Tyr Leu Met Gln Asn Trp Glu His Val Leu His 
                485                 490                 495     


Leu Met Asn His Met Asn Leu Leu Pro Leu Asp Ser His Gly Val Asp 
            500                 505                 510         


Phe Ser Arg Val Arg Met Trp Ser Leu Asn Asn Trp Ser Lys Tyr Tyr 
        515                 520                 525             


Arg Gln Thr Leu Leu Phe Gly Ala Leu Gln Asp Ala Gln Ile Asn Ser 
    530                 535                 540                 


Val Phe Asn Lys Tyr Cys Val Asn Met Gln Gly Gln Val Ala Val Arg 
545                 550                 555                 560 


Asn Val Pro Met Thr Gly Ser Ile Ser His Val Leu Val Gln Leu Pro 
                565                 570                 575     


His Val Phe Gln Arg Met Glu Ala Glu Asn Leu Ala Ser Val Ile Asp 
            580                 585                 590         


Ala Arg Phe Asn Phe Phe Val Asn Lys Ile Leu Pro Gln Tyr Arg Asp 
        595                 600                 605             


Ala Val Met Ser His Thr Leu Ile Tyr Ile Pro Ser Tyr Phe Asp Phe 
    610                 615                 620                 


Val Arg Leu Arg Asn Tyr Phe Lys Lys Glu Glu Leu Asn Phe Thr His 
625                 630                 635                 640 


Ile Cys Glu Tyr Thr Gln Lys Ser Gly Val Ser Arg Ala Arg His Phe 
                645                 650                 655     


Phe Leu Gln Gly Glu Lys Gln Phe Leu Leu Phe Thr Glu Arg Phe His 
            660                 665                 670         


Phe Tyr Lys Arg Tyr Thr Ile Lys Gly Ile Arg Asn Leu Ile Phe Tyr 
        675                 680                 685             


Glu Leu Pro Thr Tyr Pro His Phe Tyr Ser Glu Ile Cys Asn Met Leu 
    690                 695                 700                 


Arg Ala Thr Asn Arg Gly Glu Glu Ala Thr Trp Thr Cys Thr Val Leu 
705                 710                 715                 720 


Tyr Ser Lys Tyr Asp Ala Gln Arg Leu Ala Ala Val Val Gly Val Glu 
                725                 730                 735     


Arg Ala Ala Gln Met Leu Gln Ser Asn Lys Asn Val His Leu Phe Ile 
            740                 745                 750         


Thr Gly Glu Lys 
        755     


<210>  268
<211>  711
<212>  PRT
<213>  Homo sapiens

<400>  268

Met Lys Leu Lys Leu Asn Val Leu Thr Ile Ile Leu Leu Pro Val His 
1               5                   10                  15      


Leu Leu Ile Thr Ile Tyr Ser Ala Leu Ile Phe Ile Pro Trp Tyr Phe 
            20                  25                  30          


Leu Thr Asn Ala Lys Lys Lys Asn Ala Met Ala Lys Arg Ile Lys Ala 
        35                  40                  45              


Lys Pro Thr Ser Asp Lys Pro Gly Ser Pro Tyr Arg Ser Val Thr His 
    50                  55                  60                  


Phe Asp Ser Leu Ala Val Ile Asp Ile Pro Gly Ala Asp Thr Leu Asp 
65                  70                  75                  80  


Lys Leu Phe Asp His Ala Val Ser Lys Phe Gly Lys Lys Asp Ser Leu 
                85                  90                  95      


Gly Thr Arg Glu Ile Leu Ser Glu Glu Asn Glu Met Gln Pro Asn Gly 
            100                 105                 110         


Lys Val Phe Lys Lys Leu Ile Leu Gly Asn Tyr Lys Trp Met Asn Tyr 
        115                 120                 125             


Leu Glu Val Asn Arg Arg Val Asn Asn Phe Gly Ser Gly Leu Thr Ala 
    130                 135                 140                 


Leu Gly Leu Lys Pro Lys Asn Thr Ile Ala Ile Phe Cys Glu Thr Arg 
145                 150                 155                 160 


Ala Glu Trp Met Ile Ala Ala Gln Thr Cys Phe Lys Tyr Asn Phe Pro 
                165                 170                 175     


Leu Val Thr Leu Tyr Ala Thr Leu Gly Lys Glu Ala Val Val His Gly 
            180                 185                 190         


Leu Asn Glu Ser Glu Ala Ser Tyr Leu Ile Thr Ser Val Glu Leu Leu 
        195                 200                 205             


Glu Ser Lys Leu Lys Thr Ala Leu Leu Asp Ile Ser Cys Val Lys His 
    210                 215                 220                 


Ile Ile Tyr Val Asp Asn Lys Ala Ile Asn Lys Ala Glu Tyr Pro Glu 
225                 230                 235                 240 


Gly Phe Glu Ile His Ser Met Gln Ser Val Glu Glu Leu Gly Ser Asn 
                245                 250                 255     


Pro Glu Asn Leu Gly Ile Pro Pro Ser Arg Pro Thr Pro Ser Asp Met 
            260                 265                 270         


Ala Ile Val Met Tyr Thr Ser Gly Ser Thr Gly Arg Pro Lys Gly Val 
        275                 280                 285             


Met Met His His Ser Asn Leu Ile Ala Gly Met Thr Gly Gln Cys Glu 
    290                 295                 300                 


Arg Ile Pro Gly Leu Gly Pro Lys Asp Thr Tyr Ile Gly Tyr Leu Pro 
305                 310                 315                 320 


Leu Ala His Val Leu Glu Leu Thr Ala Glu Ile Ser Cys Phe Thr Tyr 
                325                 330                 335     


Gly Cys Arg Ile Gly Tyr Ser Ser Pro Leu Thr Leu Ser Asp Gln Ser 
            340                 345                 350         


Ser Lys Ile Lys Lys Gly Ser Lys Gly Asp Cys Thr Val Leu Lys Pro 
        355                 360                 365             


Thr Leu Met Ala Ala Val Pro Glu Ile Met Asp Arg Ile Tyr Lys Asn 
    370                 375                 380                 


Val Met Ser Lys Val Gln Glu Met Asn Tyr Ile Gln Lys Thr Leu Phe 
385                 390                 395                 400 


Lys Ile Gly Tyr Asp Tyr Lys Leu Glu Gln Ile Lys Lys Gly Tyr Asp 
                405                 410                 415     


Ala Pro Leu Cys Asn Leu Leu Leu Phe Lys Lys Val Lys Ala Leu Leu 
            420                 425                 430         


Gly Gly Asn Val Arg Met Met Leu Ser Gly Gly Ala Pro Leu Ser Pro 
        435                 440                 445             


Gln Thr His Arg Phe Met Asn Val Cys Phe Cys Cys Pro Ile Gly Gln 
    450                 455                 460                 


Gly Tyr Gly Leu Thr Glu Ser Cys Gly Ala Gly Thr Val Thr Glu Val 
465                 470                 475                 480 


Thr Asp Tyr Thr Thr Gly Arg Val Gly Ala Pro Leu Ile Cys Cys Glu 
                485                 490                 495     


Ile Lys Leu Lys Asp Trp Gln Glu Gly Gly Tyr Thr Ile Asn Asp Lys 
            500                 505                 510         


Pro Asn Pro Arg Gly Glu Ile Val Ile Gly Gly Gln Asn Ile Ser Met 
        515                 520                 525             


Gly Tyr Phe Lys Asn Glu Glu Lys Thr Ala Glu Asp Tyr Ser Val Asp 
    530                 535                 540                 


Glu Asn Gly Gln Arg Trp Phe Cys Thr Gly Asp Ile Gly Glu Phe His 
545                 550                 555                 560 


Pro Asp Gly Cys Leu Gln Ile Ile Asp Arg Lys Lys Asp Leu Val Lys 
                565                 570                 575     


Leu Gln Ala Gly Glu Tyr Val Ser Leu Gly Lys Val Glu Ala Ala Leu 
            580                 585                 590         


Lys Asn Cys Pro Leu Ile Asp Asn Ile Cys Ala Phe Ala Lys Ser Asp 
        595                 600                 605             


Gln Ser Tyr Val Ile Ser Phe Val Val Pro Asn Gln Lys Arg Leu Thr 
    610                 615                 620                 


Leu Leu Ala Gln Gln Lys Gly Val Glu Gly Thr Trp Val Asp Ile Cys 
625                 630                 635                 640 


Asn Asn Pro Ala Met Glu Ala Glu Ile Leu Lys Glu Ile Arg Glu Ala 
                645                 650                 655     


Ala Asn Ala Met Lys Leu Glu Arg Phe Glu Ile Pro Ile Lys Val Arg 
            660                 665                 670         


Leu Ser Pro Glu Pro Trp Thr Pro Glu Thr Gly Leu Val Thr Asp Ala 
        675                 680                 685             


Phe Lys Leu Lys Arg Lys Glu Leu Arg Asn His Tyr Leu Lys Asp Ile 
    690                 695                 700                 


Glu Arg Met Tyr Gly Gly Lys 
705                 710     


<210>  269
<211>  441
<212>  PRT
<213>  Homo sapiens

<400>  269

Met Lys Thr Leu Pro Leu His Ser His Cys Thr Glu Met Gln Arg Leu 
1               5                   10                  15      


Leu Pro Lys Leu Glu Met Leu Thr Leu Gly Ser Ser Phe Cys Ser Leu 
            20                  25                  30          


Gln Gly Glu Phe Cys Gln Ala Met Asp Ser Phe Thr Thr Val Ser His 
        35                  40                  45              


Val Gly Met Cys Glu Glu Thr Asp Ala Ser Phe Asn Val Phe Ser Pro 
    50                  55                  60                  


Lys Phe Gln Phe Asp Arg Ser His Cys Gln Ser Leu Arg Phe His Gln 
65                  70                  75                  80  


Asn Met Glu Leu Asp Phe Gly His Phe Asp Glu Arg Asp Lys Thr Ser 
                85                  90                  95      


Arg Asn Met Arg Gly Ser Arg Met Asn Gly Leu Pro Ser Pro Thr His 
            100                 105                 110         


Ser Ala His Cys Ser Phe Tyr Arg Thr Arg Thr Leu Gln Ala Leu Ser 
        115                 120                 125             


Asn Glu Lys Lys Ala Lys Lys Val Arg Phe Tyr Arg Asn Gly Asp Arg 
    130                 135                 140                 


Tyr Phe Lys Gly Ile Val Tyr Ala Val Ser Ser Asp Arg Phe Arg Ser 
145                 150                 155                 160 


Phe Asp Ala Leu Leu Ala Asp Leu Thr Arg Ser Leu Ser Asp Asn Ile 
                165                 170                 175     


Asn Leu Pro Gln Gly Val Arg Tyr Ile Tyr Thr Ile Asp Gly Ser Arg 
            180                 185                 190         


Lys Ile Gly Ser Met Asp Glu Leu Glu Glu Gly Glu Ser Tyr Val Cys 
        195                 200                 205             


Ser Ser Asp Asn Phe Phe Lys Lys Val Glu Tyr Thr Lys Asn Val Asn 
    210                 215                 220                 


Pro Asn Trp Ser Val Asn Val Lys Thr Ser Ala Asn Met Lys Ala Pro 
225                 230                 235                 240 


Gln Ser Leu Ala Ser Ser Asn Ser Ala Gln Ala Arg Glu Asn Lys Asp 
                245                 250                 255     


Phe Val Arg Pro Lys Leu Val Thr Ile Ile Arg Ser Gly Val Lys Pro 
            260                 265                 270         


Arg Lys Ala Val Arg Val Leu Leu Asn Lys Lys Thr Ala His Ser Phe 
        275                 280                 285             


Glu Gln Val Leu Thr Asp Ile Thr Glu Ala Ile Lys Leu Glu Thr Gly 
    290                 295                 300                 


Val Val Lys Lys Leu Tyr Thr Leu Asp Gly Lys Gln Val Thr Cys Leu 
305                 310                 315                 320 


His Asp Phe Phe Gly Asp Asp Asp Val Phe Ile Ala Cys Gly Pro Glu 
                325                 330                 335     


Lys Phe Arg Tyr Ala Gln Asp Asp Phe Ser Leu Asp Glu Asn Glu Cys 
            340                 345                 350         


Arg Val Met Lys Gly Asn Pro Ser Ala Thr Ala Gly Pro Lys Ala Ser 
        355                 360                 365             


Pro Thr Pro Gln Lys Thr Ser Ala Lys Ser Pro Gly Pro Met Arg Arg 
    370                 375                 380                 


Ser Lys Ser Pro Ala Asp Ser Ala Asn Gly Thr Ser Ser Ser Gln Leu 
385                 390                 395                 400 


Ser Thr Pro Lys Ser Lys Gln Ser Pro Ile Ser Thr Pro Thr Ser Pro 
                405                 410                 415     


Gly Ser Leu Arg Lys His Lys Asp Leu Tyr Leu Pro Leu Ser Leu Asp 
            420                 425                 430         


Asp Ser Asp Ser Leu Gly Asp Ser Met 
        435                 440     


<210>  270
<211>  382
<212>  PRT
<213>  Homo sapiens

<400>  270

Met Gly Ala Phe Leu Asp Lys Pro Lys Met Glu Lys His Asn Ala Gln 
1               5                   10                  15      


Gly Gln Gly Asn Gly Leu Arg Tyr Gly Leu Ser Ser Met Gln Gly Trp 
            20                  25                  30          


Arg Val Glu Met Glu Asp Ala His Thr Ala Val Ile Gly Leu Pro Ser 
        35                  40                  45              


Gly Leu Glu Ser Trp Ser Phe Phe Ala Val Tyr Asp Gly His Ala Gly 
    50                  55                  60                  


Ser Gln Val Ala Lys Tyr Cys Cys Glu His Leu Leu Asp His Ile Thr 
65                  70                  75                  80  


Asn Asn Gln Asp Phe Lys Gly Ser Ala Gly Ala Pro Ser Val Glu Asn 
                85                  90                  95      


Val Lys Asn Gly Ile Arg Thr Gly Phe Leu Glu Ile Asp Glu His Met 
            100                 105                 110         


Arg Val Met Ser Glu Lys Lys His Gly Ala Asp Arg Ser Gly Ser Thr 
        115                 120                 125             


Ala Val Gly Val Leu Ile Ser Pro Gln His Thr Tyr Phe Ile Asn Cys 
    130                 135                 140                 


Gly Asp Ser Arg Gly Leu Leu Cys Arg Asn Arg Lys Val His Phe Phe 
145                 150                 155                 160 


Thr Gln Asp His Lys Pro Ser Asn Pro Leu Glu Lys Glu Arg Ile Gln 
                165                 170                 175     


Asn Ala Gly Gly Ser Val Met Ile Gln Arg Val Asn Gly Ser Leu Ala 
            180                 185                 190         


Val Ser Arg Ala Leu Gly Asp Phe Asp Tyr Lys Cys Val His Gly Lys 
        195                 200                 205             


Gly Pro Thr Glu Gln Leu Val Ser Pro Glu Pro Glu Val His Asp Ile 
    210                 215                 220                 


Glu Arg Ser Glu Glu Asp Asp Gln Phe Ile Ile Leu Ala Cys Asp Gly 
225                 230                 235                 240 


Ile Trp Asp Val Met Gly Asn Glu Glu Leu Cys Asp Phe Val Arg Ser 
                245                 250                 255     


Arg Leu Glu Val Thr Asp Asp Leu Glu Lys Val Cys Asn Glu Val Val 
            260                 265                 270         


Asp Thr Cys Leu Tyr Lys Gly Ser Arg Asp Asn Met Ser Val Ile Leu 
        275                 280                 285             


Ile Cys Phe Pro Asn Ala Pro Lys Val Ser Pro Glu Ala Val Lys Lys 
    290                 295                 300                 


Glu Ala Glu Leu Asp Lys Tyr Leu Glu Cys Arg Val Glu Glu Ile Ile 
305                 310                 315                 320 


Lys Lys Gln Gly Glu Gly Val Pro Asp Leu Val His Val Met Arg Thr 
                325                 330                 335     


Leu Ala Ser Glu Asn Ile Pro Ser Leu Pro Pro Gly Gly Glu Leu Ala 
            340                 345                 350         


Ser Lys Arg Asn Val Ile Glu Ala Val Tyr Asn Arg Leu Asn Pro Tyr 
        355                 360                 365             


Lys Asn Asp Asp Thr Asp Ser Thr Ser Thr Asp Asp Met Trp 
    370                 375                 380         


<210>  271
<211>  360
<212>  PRT
<213>  Homo sapiens

<400>  271

Met Val Gln Ala His Gly Gly Arg Ser Arg Ala Gln Pro Leu Thr Leu 
1               5                   10                  15      


Ser Leu Gly Ala Ala Met Thr Gln Pro Pro Pro Glu Lys Thr Pro Ala 
            20                  25                  30          


Lys Lys His Val Arg Leu Gln Glu Arg Arg Gly Ser Asn Val Ala Leu 
        35                  40                  45              


Met Leu Asp Val Arg Ser Leu Gly Ala Val Glu Pro Ile Cys Ser Val 
    50                  55                  60                  


Asn Thr Pro Arg Glu Val Thr Leu His Phe Leu Arg Thr Ala Gly His 
65                  70                  75                  80  


Pro Leu Thr Arg Trp Ala Leu Gln Arg Gln Pro Pro Ser Pro Lys Gln 
                85                  90                  95      


Leu Glu Glu Glu Phe Leu Lys Ile Pro Ser Asn Phe Val Ser Pro Glu 
            100                 105                 110         


Asp Leu Asp Ile Pro Gly His Ala Ser Lys Asp Arg Tyr Lys Thr Ile 
        115                 120                 125             


Leu Pro Asn Pro Gln Ser Arg Val Cys Leu Gly Arg Ala Gln Ser Gln 
    130                 135                 140                 


Glu Asp Gly Asp Tyr Ile Asn Ala Asn Tyr Ile Arg Gly Tyr Asp Gly 
145                 150                 155                 160 


Lys Glu Lys Val Tyr Ile Ala Thr Gln Gly Pro Met Pro Asn Thr Val 
                165                 170                 175     


Ser Asp Phe Trp Glu Met Val Trp Gln Glu Glu Val Ser Leu Ile Val 
            180                 185                 190         


Met Leu Thr Gln Leu Arg Glu Gly Lys Glu Lys Cys Val His Tyr Trp 
        195                 200                 205             


Pro Thr Glu Glu Glu Thr Tyr Gly Pro Phe Gln Ile Arg Ile Gln Asp 
    210                 215                 220                 


Met Lys Glu Cys Pro Glu Tyr Thr Val Arg Gln Leu Thr Ile Gln Tyr 
225                 230                 235                 240 


Gln Glu Glu Arg Arg Ser Val Lys His Ile Leu Phe Ser Ala Trp Pro 
                245                 250                 255     


Asp His Gln Thr Pro Glu Ser Ala Gly Pro Leu Leu Arg Leu Val Ala 
            260                 265                 270         


Glu Val Glu Glu Ser Pro Glu Thr Ala Ala His Pro Gly Pro Ile Val 
        275                 280                 285             


Val His Cys Ser Ala Gly Ile Gly Arg Thr Gly Cys Phe Ile Ala Thr 
    290                 295                 300                 


Arg Ile Gly Cys Gln Gln Leu Lys Ala Arg Gly Glu Val Asp Ile Leu 
305                 310                 315                 320 


Gly Ile Val Cys Gln Leu Arg Leu Asp Arg Gly Gly Met Ile Gln Thr 
                325                 330                 335     


Ala Glu Gln Tyr Gln Phe Leu His His Thr Leu Ala Leu Tyr Ala Gly 
            340                 345                 350         


Gln Leu Pro Glu Glu Pro Ser Pro 
        355                 360 


<210>  272
<211>  109
<212>  PRT
<213>  Homo sapiens

<400>  272

Met Ala Val Val Gly Val Ser Ser Val Ser Arg Leu Leu Gly Arg Ser 
1               5                   10                  15      


Arg Pro Gln Leu Gly Arg Pro Met Ser Ser Gly Ala His Gly Glu Glu 
            20                  25                  30          


Gly Ser Ala Arg Met Trp Lys Thr Leu Thr Phe Phe Val Ala Leu Pro 
        35                  40                  45              


Gly Val Ala Val Ser Met Leu Asn Val Tyr Leu Lys Ser His His Gly 
    50                  55                  60                  


Glu His Glu Arg Pro Glu Phe Ile Ala Tyr Pro His Leu Arg Ile Arg 
65                  70                  75                  80  


Thr Lys Pro Phe Pro Trp Gly Asp Gly Asn His Thr Leu Phe His Asn 
                85                  90                  95      


Pro His Val Asn Pro Leu Pro Thr Gly Tyr Glu Asp Glu 
            100                 105                 


<210>  273
<211>  322
<212>  PRT
<213>  Homo sapiens

<400>  273

Met Glu Gly Ile Ser Asn Phe Lys Thr Pro Ser Lys Leu Ser Glu Lys 
1               5                   10                  15      


Lys Lys Ser Val Leu Cys Ser Thr Pro Thr Ile Asn Ile Pro Ala Ser 
            20                  25                  30          


Pro Phe Met Gln Lys Leu Gly Phe Gly Thr Gly Val Asn Val Tyr Leu 
        35                  40                  45              


Met Lys Arg Ser Pro Arg Gly Leu Ser His Ser Pro Trp Ala Val Lys 
    50                  55                  60                  


Lys Ile Asn Pro Ile Cys Asn Asp His Tyr Arg Ser Val Tyr Gln Lys 
65                  70                  75                  80  


Arg Leu Met Asp Glu Ala Lys Ile Leu Lys Ser Leu His His Pro Asn 
                85                  90                  95      


Ile Val Gly Tyr Arg Ala Phe Thr Glu Ala Asn Asp Gly Ser Leu Cys 
            100                 105                 110         


Leu Ala Met Glu Tyr Gly Gly Glu Lys Ser Leu Asn Asp Leu Ile Glu 
        115                 120                 125             


Glu Arg Tyr Lys Ala Ser Gln Asp Pro Phe Pro Ala Ala Ile Ile Leu 
    130                 135                 140                 


Lys Val Ala Leu Asn Met Ala Arg Gly Leu Lys Tyr Leu His Gln Glu 
145                 150                 155                 160 


Lys Lys Leu Leu His Gly Asp Ile Lys Ser Ser Asn Val Val Ile Lys 
                165                 170                 175     


Gly Asp Phe Glu Thr Ile Lys Ile Cys Asp Val Gly Val Ser Leu Pro 
            180                 185                 190         


Leu Asp Glu Asn Met Thr Val Thr Asp Pro Glu Ala Cys Tyr Ile Gly 
        195                 200                 205             


Thr Glu Pro Trp Lys Pro Lys Glu Ala Val Glu Glu Asn Gly Val Ile 
    210                 215                 220                 


Thr Asp Lys Ala Asp Ile Phe Ala Phe Gly Leu Thr Leu Trp Glu Met 
225                 230                 235                 240 


Met Thr Leu Ser Ile Pro His Ile Asn Leu Ser Asn Asp Asp Asp Asp 
                245                 250                 255     


Glu Asp Lys Thr Phe Asp Glu Ser Asp Phe Asp Asp Glu Ala Tyr Tyr 
            260                 265                 270         


Ala Ala Leu Gly Thr Arg Pro Pro Ile Asn Met Glu Glu Leu Asp Glu 
        275                 280                 285             


Ser Tyr Gln Lys Val Ile Glu Leu Phe Ser Val Cys Thr Asn Glu Asp 
    290                 295                 300                 


Pro Lys Asp Arg Pro Ser Ala Ala His Ile Val Glu Ala Leu Glu Thr 
305                 310                 315                 320 


Asp Val 
        


<210>  274
<211>  276
<212>  PRT
<213>  Homo sapiens

<400>  274

Met Ala Ala Gly Phe Lys Thr Val Glu Pro Leu Glu Tyr Tyr Arg Arg 
1               5                   10                  15      


Phe Leu Lys Glu Asn Cys Arg Pro Asp Gly Arg Glu Leu Gly Glu Phe 
            20                  25                  30          


Arg Thr Thr Thr Val Asn Ile Gly Ser Ile Ser Thr Ala Asp Gly Ser 
        35                  40                  45              


Ala Leu Val Lys Leu Gly Asn Thr Thr Val Ile Cys Gly Val Lys Ala 
    50                  55                  60                  


Glu Phe Ala Ala Pro Ser Thr Asp Ala Pro Asp Lys Gly Tyr Val Val 
65                  70                  75                  80  


Pro Asn Val Asp Leu Pro Pro Leu Cys Ser Ser Arg Phe Arg Ser Gly 
                85                  90                  95      


Pro Pro Gly Glu Glu Ala Gln Val Ala Ser Gln Phe Ile Ala Asp Val 
            100                 105                 110         


Ile Glu Asn Ser Gln Ile Ile Gln Lys Glu Asp Leu Cys Ile Ser Pro 
        115                 120                 125             


Gly Lys Leu Val Trp Val Leu Tyr Cys Asp Leu Ile Cys Leu Asp Tyr 
    130                 135                 140                 


Asp Gly Asn Ile Leu Asp Ala Cys Thr Phe Ala Leu Leu Ala Ala Leu 
145                 150                 155                 160 


Lys Asn Val Gln Leu Pro Glu Val Thr Ile Asn Glu Glu Thr Ala Leu 
                165                 170                 175     


Ala Glu Val Asn Leu Lys Lys Lys Ser Tyr Leu Asn Ile Arg Thr His 
            180                 185                 190         


Pro Val Ala Thr Ser Phe Ala Val Phe Asp Asp Thr Leu Leu Ile Val 
        195                 200                 205             


Asp Pro Thr Gly Glu Glu Glu His Leu Ala Thr Gly Thr Leu Thr Ile 
    210                 215                 220                 


Val Met Asp Glu Glu Gly Lys Leu Cys Cys Leu His Lys Pro Gly Gly 
225                 230                 235                 240 


Ser Gly Leu Thr Gly Ala Lys Leu Gln Asp Cys Met Ser Arg Ala Val 
                245                 250                 255     


Thr Arg His Lys Glu Val Lys Lys Leu Met Asp Glu Val Ile Lys Ser 
            260                 265                 270         


Met Lys Pro Lys 
        275     


<210>  275
<211>  209
<212>  PRT
<213>  Homo sapiens

<400>  275

Met Asp Ser Asp Glu Thr Gly Phe Glu His Ser Gly Leu Trp Val Ser 
1               5                   10                  15      


Val Leu Ala Gly Leu Leu Leu Gly Ala Cys Gln Ala His Pro Ile Pro 
            20                  25                  30          


Asp Ser Ser Pro Leu Leu Gln Phe Gly Gly Gln Val Arg Gln Arg Tyr 
        35                  40                  45              


Leu Tyr Thr Asp Asp Ala Gln Gln Thr Glu Ala His Leu Glu Ile Arg 
    50                  55                  60                  


Glu Asp Gly Thr Val Gly Gly Ala Ala Asp Gln Ser Pro Glu Ser Leu 
65                  70                  75                  80  


Leu Gln Leu Lys Ala Leu Lys Pro Gly Val Ile Gln Ile Leu Gly Val 
                85                  90                  95      


Lys Thr Ser Arg Phe Leu Cys Gln Arg Pro Asp Gly Ala Leu Tyr Gly 
            100                 105                 110         


Ser Leu His Phe Asp Pro Glu Ala Cys Ser Phe Arg Glu Leu Leu Leu 
        115                 120                 125             


Glu Asp Gly Tyr Asn Val Tyr Gln Ser Glu Ala His Gly Leu Pro Leu 
    130                 135                 140                 


His Leu Pro Gly Asn Lys Ser Pro His Arg Asp Pro Ala Pro Arg Gly 
145                 150                 155                 160 


Pro Ala Arg Phe Leu Pro Leu Pro Gly Leu Pro Pro Ala Leu Pro Glu 
                165                 170                 175     


Pro Pro Gly Ile Leu Ala Pro Gln Pro Pro Asp Val Gly Ser Ser Asp 
            180                 185                 190         


Pro Leu Ser Met Val Gly Pro Ser Gln Gly Arg Ser Pro Ser Tyr Ala 
        195                 200                 205             


Ser 
    


<210>  276
<211>  361
<212>  PRT
<213>  Homo sapiens

<400>  276

Met Ser Lys Cys Ala Arg Lys Lys Tyr Ile Lys Thr Asn Pro Arg Gln 
1               5                   10                  15      


Met Thr Met Glu Thr Val Glu Ser Gln His Asp Gly Ser Ile Thr Ala 
            20                  25                  30          


Ser Leu Thr Glu Ser Lys Ser Ala His Val Gln Thr Gln Thr Gly Gln 
        35                  40                  45              


Asn Ser Ile Pro Ala Leu Ala Gln Val Ser Val Ala Gly Ser Gly Thr 
    50                  55                  60                  


Arg Arg Gly Ser Pro Ala Val Thr Leu Val Gln Leu Pro Ser Gly Gln 
65                  70                  75                  80  


Thr Ile His Val Gln Gly Val Ile Gln Thr Pro Gln Pro Trp Val Ile 
                85                  90                  95      


Gln Ser Ser Glu Ile His Thr Val Gln Val Ala Ala Ile Ala Glu Thr 
            100                 105                 110         


Asp Glu Ser Ala Glu Ser Glu Gly Val Ile Asp Ser His Lys Arg Arg 
        115                 120                 125             


Glu Ile Leu Ser Arg Arg Pro Ser Tyr Arg Lys Ile Leu Asn Glu Leu 
    130                 135                 140                 


Ser Ser Asp Val Pro Gly Val Pro Lys Ile Glu Glu Glu Arg Ser Glu 
145                 150                 155                 160 


Glu Glu Gly Thr Pro Pro Ser Ile Ala Thr Met Ala Val Pro Thr Ser 
                165                 170                 175     


Ile Tyr Gln Thr Ser Thr Gly Gln Tyr Ile Ala Ile Ala Gln Gly Gly 
            180                 185                 190         


Thr Ile Gln Ile Ser Asn Pro Gly Ser Asp Gly Val Gln Gly Leu Gln 
        195                 200                 205             


Ala Leu Thr Met Thr Asn Ser Gly Ala Pro Pro Pro Gly Ala Thr Ile 
    210                 215                 220                 


Val Gln Tyr Ala Ala Gln Ser Ala Asp Gly Thr Gln Gln Phe Phe Val 
225                 230                 235                 240 


Pro Gly Ser Gln Val Val Val Gln Asp Glu Glu Thr Glu Leu Ala Pro 
                245                 250                 255     


Ser His Met Ala Ala Ala Thr Gly Asp Met Pro Thr Tyr Gln Ile Arg 
            260                 265                 270         


Ala Pro Thr Ala Ala Leu Pro Gln Gly Val Val Met Ala Ala Ser Pro 
        275                 280                 285             


Gly Ser Leu His Ser Pro Gln Gln Leu Ala Glu Glu Ala Thr Arg Lys 
    290                 295                 300                 


Arg Glu Leu Arg Leu Met Lys Asn Arg Glu Ala Ala Lys Glu Cys Arg 
305                 310                 315                 320 


Arg Arg Lys Lys Glu Tyr Val Lys Cys Leu Glu Ser Arg Val Ala Val 
                325                 330                 335     


Leu Glu Val Gln Asn Lys Lys Leu Ile Glu Glu Leu Glu Thr Leu Lys 
            340                 345                 350         


Asp Ile Cys Ser Pro Lys Thr Asp Tyr 
        355                 360     


<210>  277
<211>  591
<212>  PRT
<213>  Homo sapiens

<400>  277

Met Asp Asp Leu Asp Ala Leu Leu Ala Asp Leu Glu Ser Thr Thr Ser 
1               5                   10                  15      


His Ile Ser Lys Arg Pro Val Phe Leu Ser Glu Glu Thr Pro Tyr Ser 
            20                  25                  30          


Tyr Pro Thr Gly Asn His Thr Tyr Gln Glu Ile Ala Val Pro Pro Pro 
        35                  40                  45              


Val Pro Pro Pro Pro Ser Ser Glu Ala Leu Asn Gly Thr Ile Leu Asp 
    50                  55                  60                  


Pro Leu Asp Gln Trp Gln Pro Ser Gly Ser Arg Phe Ile His Gln Gln 
65                  70                  75                  80  


Pro Gln Ser Ser Ser Pro Val Tyr Gly Ser Ser Ala Lys Thr Ser Ser 
                85                  90                  95      


Val Ser Asn Pro Gln Asp Ser Val Gly Ser Pro Cys Ser Arg Val Gly 
            100                 105                 110         


Glu Glu Glu His Val Tyr Ser Phe Pro Asn Lys Gln Lys Ser Ala Glu 
        115                 120                 125             


Pro Ser Pro Thr Val Met Ser Thr Ser Leu Gly Ser Asn Leu Ser Glu 
    130                 135                 140                 


Leu Asp Arg Leu Leu Leu Glu Leu Asn Ala Val Gln His Asn Pro Pro 
145                 150                 155                 160 


Gly Phe Pro Ala Asp Glu Ala Asn Ser Ser Pro Pro Leu Pro Gly Ala 
                165                 170                 175     


Leu Ser Pro Leu Tyr Gly Val Pro Glu Thr Asn Ser Pro Leu Gly Gly 
            180                 185                 190         


Lys Ala Gly Pro Leu Thr Lys Glu Lys Pro Lys Arg Asn Gly Gly Arg 
        195                 200                 205             


Gly Leu Glu Asp Val Arg Pro Ser Val Glu Ser Leu Leu Asp Glu Leu 
    210                 215                 220                 


Glu Ser Ser Val Pro Ser Pro Val Pro Ala Ile Thr Val Asn Gln Gly 
225                 230                 235                 240 


Glu Met Ser Ser Pro Gln Arg Val Thr Ser Thr Gln Gln Gln Thr Arg 
                245                 250                 255     


Ile Ser Ala Ser Ser Ala Thr Arg Glu Leu Asp Glu Leu Met Ala Ser 
            260                 265                 270         


Leu Ser Asp Phe Lys Ile Gln Asp Leu Glu Gln Arg Ala Asp Gly Glu 
        275                 280                 285             


Arg Cys Trp Ala Ala Gly Trp Pro Arg Asp Gly Gly Arg Ser Ser Pro 
    290                 295                 300                 


Gly Gly Gln Asp Glu Gly Gly Phe Met Ala Gln Gly Lys Thr Gly Ser 
305                 310                 315                 320 


Ser Ser Pro Pro Gly Gly Pro Pro Lys Pro Gly Ser Gln Leu Asp Ser 
                325                 330                 335     


Met Leu Gly Ser Leu Gln Ser Asp Leu Asn Lys Leu Gly Val Ala Thr 
            340                 345                 350         


Val Ala Lys Gly Val Cys Gly Ala Cys Lys Lys Pro Ile Ala Gly Gln 
        355                 360                 365             


Val Val Thr Ala Met Gly Lys Thr Trp His Pro Glu His Phe Val Cys 
    370                 375                 380                 


Thr His Cys Gln Glu Glu Ile Gly Ser Arg Asn Phe Phe Glu Arg Asp 
385                 390                 395                 400 


Gly Gln Pro Tyr Cys Glu Lys Asp Tyr His Asn Leu Phe Ser Pro Arg 
                405                 410                 415     


Cys Tyr Tyr Cys Asn Gly Pro Ile Leu Asp Lys Val Val Thr Ala Leu 
            420                 425                 430         


Asp Arg Thr Trp His Pro Glu His Phe Phe Cys Ala Gln Cys Gly Ala 
        435                 440                 445             


Phe Phe Gly Pro Glu Gly Phe His Glu Lys Asp Gly Lys Ala Tyr Cys 
    450                 455                 460                 


Arg Lys Asp Tyr Phe Asp Met Phe Ala Pro Lys Cys Gly Gly Cys Ala 
465                 470                 475                 480 


Arg Ala Ile Leu Glu Asn Tyr Ile Ser Ala Leu Asn Thr Leu Trp His 
                485                 490                 495     


Pro Glu Cys Phe Val Cys Arg Glu Cys Phe Thr Pro Phe Val Asn Gly 
            500                 505                 510         


Ser Phe Phe Glu His Asp Gly Gln Pro Tyr Cys Glu Val His Tyr His 
        515                 520                 525             


Glu Arg Arg Gly Ser Leu Cys Ser Gly Cys Gln Lys Pro Ile Thr Gly 
    530                 535                 540                 


Arg Cys Ile Thr Ala Met Ala Lys Lys Phe His Pro Glu His Phe Val 
545                 550                 555                 560 


Cys Ala Phe Cys Leu Lys Gln Leu Asn Lys Gly Thr Phe Lys Glu Gln 
                565                 570                 575     


Asn Asp Lys Pro Tyr Cys Gln Asn Cys Phe Leu Lys Leu Phe Cys 
            580                 585                 590     


<210>  278
<211>  120
<212>  PRT
<213>  Homo sapiens

<400>  278

Met Ala Gly Asn His Cys Glu Leu Leu Pro Leu Ala Arg Gly Arg Leu 
1               5                   10                  15      


Gly Ala Gly Leu Gly Trp Leu Leu Val Pro Pro Leu Lys Arg Gly Ala 
            20                  25                  30          


Gln Arg Pro Gly Pro Ala Pro Gln Gln Gln Val Gln Val Gly Pro Ala 
        35                  40                  45              


Leu Gln Arg Arg His Leu Leu Pro His His Trp Ala Asp Ala Ala Val 
    50                  55                  60                  


Ser Gly Pro Glu Ile Leu Pro Val Pro Leu Glu Pro Gly Arg Pro Arg 
65                  70                  75                  80  


Pro Gly Leu Gly Gln Asp Gly Val Leu Phe Leu Leu Pro Lys Leu Glu 
                85                  90                  95      


Tyr Asn Gly Thr Ile Leu Ala His His Asn Leu Cys His Leu Gly Ser 
            100                 105                 110         


Ser Glu Ser Pro Pro Ser Val Ser 
        115                 120 


<210>  279
<211>  527
<212>  PRT
<213>  Homo sapiens

<400>  279

Met Ala Asp Ser Arg Asp Pro Ala Ser Asp Gln Met Gln His Trp Lys 
1               5                   10                  15      


Glu Gln Arg Ala Ala Gln Lys Ala Asp Val Leu Thr Thr Gly Ala Gly 
            20                  25                  30          


Asn Pro Val Gly Asp Lys Leu Asn Val Ile Thr Val Gly Pro Arg Gly 
        35                  40                  45              


Pro Leu Leu Val Gln Asp Val Val Phe Thr Asp Glu Met Ala His Phe 
    50                  55                  60                  


Asp Arg Glu Arg Ile Pro Glu Arg Val Val His Ala Lys Gly Ala Gly 
65                  70                  75                  80  


Ala Phe Gly Tyr Phe Glu Val Thr His Asp Ile Thr Lys Tyr Ser Lys 
                85                  90                  95      


Ala Lys Val Phe Glu His Ile Gly Lys Lys Thr Pro Ile Ala Val Arg 
            100                 105                 110         


Phe Ser Thr Val Ala Gly Glu Ser Gly Ser Ala Asp Thr Val Arg Asp 
        115                 120                 125             


Pro Arg Gly Phe Ala Val Lys Phe Tyr Thr Glu Asp Gly Asn Trp Asp 
    130                 135                 140                 


Leu Val Gly Asn Asn Thr Pro Ile Phe Phe Ile Arg Asp Pro Ile Leu 
145                 150                 155                 160 


Phe Pro Ser Phe Ile His Ser Gln Lys Arg Asn Pro Gln Thr His Leu 
                165                 170                 175     


Lys Asp Pro Asp Met Val Trp Asp Phe Trp Ser Leu Arg Pro Glu Ser 
            180                 185                 190         


Leu His Gln Val Ser Phe Leu Phe Ser Asp Arg Gly Ile Pro Asp Gly 
        195                 200                 205             


His Arg His Met Asn Gly Tyr Gly Ser His Thr Phe Lys Leu Val Asn 
    210                 215                 220                 


Ala Asn Gly Glu Ala Val Tyr Cys Lys Phe His Tyr Lys Thr Asp Gln 
225                 230                 235                 240 


Gly Ile Lys Asn Leu Ser Val Glu Asp Ala Ala Arg Leu Ser Gln Glu 
                245                 250                 255     


Asp Pro Asp Tyr Gly Ile Arg Asp Leu Phe Asn Ala Ile Ala Thr Gly 
            260                 265                 270         


Lys Tyr Pro Ser Trp Thr Phe Tyr Ile Gln Val Met Thr Phe Asn Gln 
        275                 280                 285             


Ala Glu Thr Phe Pro Phe Asn Pro Phe Asp Leu Thr Lys Val Trp Pro 
    290                 295                 300                 


His Lys Asp Tyr Pro Leu Ile Pro Val Gly Lys Leu Val Leu Asn Arg 
305                 310                 315                 320 


Asn Pro Val Asn Tyr Phe Ala Glu Val Glu Gln Ile Ala Phe Asp Pro 
                325                 330                 335     


Ser Asn Met Pro Pro Gly Ile Glu Ala Ser Pro Asp Lys Met Leu Gln 
            340                 345                 350         


Gly Arg Leu Phe Ala Tyr Pro Asp Thr His Arg His Arg Leu Gly Pro 
        355                 360                 365             


Asn Tyr Leu His Ile Pro Val Asn Cys Pro Tyr Arg Ala Arg Val Ala 
    370                 375                 380                 


Asn Tyr Gln Arg Asp Gly Pro Met Cys Met Gln Asp Asn Gln Gly Gly 
385                 390                 395                 400 


Ala Pro Asn Tyr Tyr Pro Asn Ser Phe Gly Ala Pro Glu Gln Gln Pro 
                405                 410                 415     


Ser Ala Leu Glu His Ser Ile Gln Tyr Ser Gly Glu Val Arg Arg Phe 
            420                 425                 430         


Asn Thr Ala Asn Asp Asp Asn Val Thr Gln Val Arg Ala Phe Tyr Val 
        435                 440                 445             


Asn Val Leu Asn Glu Glu Gln Arg Lys Arg Leu Cys Glu Asn Ile Ala 
    450                 455                 460                 


Gly His Leu Lys Asp Ala Gln Ile Phe Ile Gln Lys Lys Ala Val Lys 
465                 470                 475                 480 


Asn Phe Thr Glu Val His Pro Asp Tyr Gly Ser His Ile Gln Ala Leu 
                485                 490                 495     


Leu Asp Lys Tyr Asn Ala Glu Lys Pro Lys Asn Ala Ile His Thr Phe 
            500                 505                 510         


Val Gln Ser Gly Ser His Leu Ala Ala Arg Glu Lys Ala Asn Leu 
        515                 520                 525         


<210>  280
<211>  542
<212>  PRT
<213>  Homo sapiens

<400>  280

Met Glu Pro Asp Ser Val Ile Glu Asp Lys Thr Ile Glu Leu Met Cys 
1               5                   10                  15      


Ser Val Pro Arg Ser Leu Trp Leu Gly Cys Ala Asn Leu Val Glu Ser 
            20                  25                  30          


Met Cys Ala Leu Ser Cys Leu Gln Ser Met Pro Ser Val Arg Cys Leu 
        35                  40                  45              


Gln Ile Ser Asn Gly Thr Ser Ser Val Ile Val Ser Arg Lys Arg Pro 
    50                  55                  60                  


Ser Glu Gly Asn Tyr Gln Lys Glu Lys Asp Leu Cys Ile Lys Tyr Phe 
65                  70                  75                  80  


Asp Gln Trp Ser Glu Ser Asp Gln Val Glu Phe Val Glu His Leu Ile 
                85                  90                  95      


Ser Arg Met Cys His Tyr Gln His Gly His Ile Asn Ser Tyr Leu Lys 
            100                 105                 110         


Pro Met Leu Gln Arg Asp Phe Ile Thr Ala Leu Pro Glu Gln Gly Leu 
        115                 120                 125             


Asp His Ile Ala Glu Asn Ile Leu Ser Tyr Leu Asp Ala Arg Ser Leu 
    130                 135                 140                 


Cys Ala Ala Glu Leu Val Cys Lys Glu Trp Gln Arg Val Ile Ser Glu 
145                 150                 155                 160 


Gly Met Leu Trp Lys Lys Leu Ile Glu Arg Met Val Arg Thr Asp Pro 
                165                 170                 175     


Leu Trp Lys Gly Leu Ser Glu Arg Arg Gly Trp Asp Gln Tyr Leu Phe 
            180                 185                 190         


Lys Asn Arg Pro Thr Asp Gly Pro Pro Asn Ser Phe Tyr Arg Ser Leu 
        195                 200                 205             


Tyr Pro Lys Ile Ile Gln Asp Ile Glu Thr Ile Glu Ser Asn Trp Arg 
    210                 215                 220                 


Cys Gly Arg His Asn Leu Gln Arg Ile Gln Cys Arg Ser Glu Asn Ser 
225                 230                 235                 240 


Lys Gly Val Tyr Cys Leu Gln Tyr Asp Asp Glu Lys Ile Ile Ser Gly 
                245                 250                 255     


Leu Arg Asp Asn Ser Ile Lys Ile Trp Asp Lys Thr Ser Leu Glu Cys 
            260                 265                 270         


Leu Lys Val Leu Thr Gly His Thr Gly Ser Val Leu Cys Leu Gln Tyr 
        275                 280                 285             


Asp Glu Arg Val Ile Val Thr Gly Ser Ser Asp Ser Thr Val Arg Val 
    290                 295                 300                 


Trp Asp Val Asn Thr Gly Glu Val Leu Asn Thr Leu Ile His His Asn 
305                 310                 315                 320 


Glu Ala Val Leu His Leu Arg Phe Ser Asn Gly Leu Met Val Thr Cys 
                325                 330                 335     


Ser Lys Asp Arg Ser Ile Ala Val Trp Asp Met Ala Ser Ala Thr Asp 
            340                 345                 350         


Ile Thr Leu Arg Arg Val Leu Val Gly His Arg Ala Ala Val Asn Val 
        355                 360                 365             


Val Asp Phe Asp Asp Lys Tyr Ile Val Ser Ala Ser Gly Asp Arg Thr 
    370                 375                 380                 


Ile Lys Val Trp Ser Thr Ser Thr Cys Glu Phe Val Arg Thr Leu Asn 
385                 390                 395                 400 


Gly His Lys Arg Gly Ile Ala Cys Leu Gln Tyr Arg Asp Arg Leu Val 
                405                 410                 415     


Val Ser Gly Ser Ser Asp Asn Thr Ile Arg Leu Trp Asp Ile Glu Cys 
            420                 425                 430         


Gly Ala Cys Leu Arg Val Leu Glu Gly His Glu Glu Leu Val Arg Cys 
        435                 440                 445             


Ile Arg Phe Asp Asn Lys Arg Ile Val Ser Gly Ala Tyr Asp Gly Lys 
    450                 455                 460                 


Ile Lys Val Trp Asp Leu Gln Ala Ala Leu Asp Pro Arg Ala Pro Ala 
465                 470                 475                 480 


Ser Thr Leu Cys Leu Arg Thr Leu Val Glu His Ser Gly Arg Val Phe 
                485                 490                 495     


Arg Leu Gln Phe Asp Glu Phe Gln Ile Ile Ser Ser Ser His Asp Asp 
            500                 505                 510         


Thr Ile Leu Ile Trp Asp Phe Leu Asn Val Pro Pro Ser Ala Gln Asn 
        515                 520                 525             


Glu Thr Arg Ser Pro Ser Arg Thr Tyr Thr Tyr Ile Ser Arg 
    530                 535                 540         


<210>  281
<211>  199
<212>  PRT
<213>  Homo sapiens

<400>  281

Met Glu Ala Arg Asp Lys Gln Val Leu Arg Ser Leu Arg Leu Glu Leu 
1               5                   10                  15      


Gly Ala Glu Val Leu Val Glu Gly Leu Val Leu Gln Tyr Leu Tyr Gln 
            20                  25                  30          


Glu Gly Ile Leu Thr Glu Asn His Ile Gln Glu Ile Asn Ala Gln Thr 
        35                  40                  45              


Thr Gly Leu Arg Lys Thr Met Leu Leu Leu Asp Ile Leu Pro Ser Arg 
    50                  55                  60                  


Gly Pro Lys Ala Phe Asp Thr Phe Leu Asp Ser Leu Gln Glu Phe Pro 
65                  70                  75                  80  


Trp Val Arg Glu Lys Leu Lys Lys Ala Arg Glu Glu Ala Met Thr Asp 
                85                  90                  95      


Leu Pro Ala Gly Asp Arg Leu Thr Gly Ile Pro Ser His Ile Leu Asn 
            100                 105                 110         


Ser Ser Pro Ser Asp Arg Gln Ile Asn Gln Leu Ala Gln Arg Leu Gly 
        115                 120                 125             


Pro Glu Trp Glu Pro Met Val Leu Ser Leu Gly Leu Ser Gln Thr Asp 
    130                 135                 140                 


Ile Tyr Arg Cys Lys Ala Asn His Pro His Asn Val Gln Ser Gln Val 
145                 150                 155                 160 


Val Glu Ala Phe Ile Arg Trp Arg Gln Arg Phe Gly Lys Gln Ala Thr 
                165                 170                 175     


Phe Gln Ser Leu His Asn Gly Leu Arg Ala Val Glu Val Asp Pro Ser 
            180                 185                 190         


Leu Leu Leu His Met Leu Glu 
        195                 


<210>  282
<211>  580
<212>  PRT
<213>  Homo sapiens

<400>  282

Met Glu Val Pro Gln Pro Glu Pro Ala Pro Gly Ser Ala Leu Ser Pro 
1               5                   10                  15      


Ala Gly Val Cys Gly Gly Ala Gln Arg Pro Gly His Leu Pro Gly Leu 
            20                  25                  30          


Leu Leu Gly Ser His Gly Leu Leu Gly Ser Pro Val Arg Ala Ala Ala 
        35                  40                  45              


Ser Ser Pro Val Thr Thr Leu Thr Gln Thr Met His Asp Leu Ala Gly 
    50                  55                  60                  


Leu Gly Ser Glu Thr Pro Lys Ser Gln Val Gly Thr Leu Leu Phe Arg 
65                  70                  75                  80  


Ser Arg Ser Arg Leu Thr His Leu Ser Leu Ser Arg Arg Ala Ser Glu 
                85                  90                  95      


Ser Ser Leu Ser Ser Glu Ser Ser Glu Ser Ser Asp Ala Gly Leu Cys 
            100                 105                 110         


Met Asp Ser Pro Ser Pro Met Asp Pro His Met Ala Glu Gln Thr Phe 
        115                 120                 125             


Glu Gln Ala Ile Gln Ala Ala Ser Arg Ile Ile Arg Asn Glu Gln Phe 
    130                 135                 140                 


Ala Ile Arg Arg Phe Gln Ser Met Pro Val Arg Leu Leu Gly His Ser 
145                 150                 155                 160 


Pro Val Leu Arg Asn Ile Thr Asn Ser Gln Ala Pro Asp Gly Arg Arg 
                165                 170                 175     


Lys Ser Glu Ala Gly Ser Gly Ala Ala Ser Ser Ser Gly Glu Asp Lys 
            180                 185                 190         


Glu Asn Asp Gly Phe Val Phe Lys Met Pro Trp Lys Pro Thr His Pro 
        195                 200                 205             


Ser Ser Thr His Ala Leu Ala Glu Trp Ala Ser Arg Arg Glu Ala Phe 
    210                 215                 220                 


Ala Gln Arg Pro Ser Ser Ala Pro Asp Leu Met Cys Leu Ser Pro Asp 
225                 230                 235                 240 


Arg Lys Met Glu Val Glu Glu Leu Ser Pro Leu Ala Leu Gly Arg Phe 
                245                 250                 255     


Ser Leu Thr Pro Ala Glu Gly Asp Thr Glu Glu Asp Asp Gly Phe Val 
            260                 265                 270         


Asp Ile Leu Glu Ser Asp Leu Lys Asp Asp Asp Ala Val Pro Pro Gly 
        275                 280                 285             


Met Glu Ser Leu Ile Ser Ala Pro Leu Val Lys Thr Leu Glu Lys Glu 
    290                 295                 300                 


Glu Glu Lys Asp Leu Val Met Tyr Ser Lys Cys Gln Arg Leu Phe Arg 
305                 310                 315                 320 


Ser Pro Ser Met Pro Cys Ser Val Ile Arg Pro Ile Leu Lys Arg Leu 
                325                 330                 335     


Glu Arg Pro Gln Asp Arg Asp Thr Pro Val Gln Asn Lys Arg Arg Arg 
            340                 345                 350         


Ser Val Thr Pro Pro Glu Glu Gln Gln Glu Ala Glu Glu Pro Lys Ala 
        355                 360                 365             


Arg Val Leu Arg Ser Lys Ser Leu Cys His Asp Glu Ile Glu Asn Leu 
    370                 375                 380                 


Leu Asp Ser Asp His Arg Glu Leu Ile Gly Asp Tyr Ser Lys Ala Phe 
385                 390                 395                 400 


Leu Leu Gln Thr Val Asp Gly Lys His Gln Asp Leu Lys Tyr Ile Ser 
                405                 410                 415     


Pro Glu Thr Met Val Ala Leu Leu Thr Gly Lys Phe Ser Asn Ile Val 
            420                 425                 430         


Asp Lys Phe Val Ile Val Asp Cys Arg Tyr Pro Tyr Glu Tyr Glu Gly 
        435                 440                 445             


Gly His Ile Lys Thr Ala Val Asn Leu Pro Leu Glu Arg Asp Ala Glu 
    450                 455                 460                 


Ser Phe Leu Leu Lys Ser Pro Ile Ala Pro Cys Ser Leu Asp Lys Arg 
465                 470                 475                 480 


Val Ile Leu Ile Phe His Cys Glu Phe Ser Ser Glu Arg Gly Pro Arg 
                485                 490                 495     


Met Cys Arg Phe Ile Arg Glu Arg Asp Arg Ala Val Asn Asp Tyr Pro 
            500                 505                 510         


Ser Leu Tyr Tyr Pro Glu Met Tyr Ile Leu Lys Gly Gly Tyr Lys Glu 
        515                 520                 525             


Phe Phe Pro Gln His Pro Asn Phe Cys Glu Pro Gln Asp Tyr Arg Pro 
    530                 535                 540                 


Met Asn His Glu Ala Phe Lys Asp Glu Leu Lys Thr Phe Arg Leu Lys 
545                 550                 555                 560 


Thr Arg Ser Trp Ala Gly Glu Arg Ser Arg Arg Glu Leu Cys Ser Arg 
                565                 570                 575     


Leu Gln Asp Gln 
            580 


<210>  283
<211>  1182
<212>  PRT
<213>  Homo sapiens

<400>  283

Met Gly Gln Gln Val Gly Arg Val Gly Glu Ala Pro Gly Leu Gln Gln 
1               5                   10                  15      


Pro Gln Pro Arg Gly Ile Arg Gly Ser Ser Ala Ala Arg Pro Ser Gly 
            20                  25                  30          


Arg Arg Arg Asp Pro Ala Gly Arg Thr Thr Glu Thr Gly Phe Asn Ile 
        35                  40                  45              


Phe Thr Gln His Asp His Phe Ala Ser Cys Val Glu Asp Gly Phe Glu 
    50                  55                  60                  


Gly Asp Lys Thr Gly Gly Ser Ser Pro Glu Ala Leu His Arg Pro Tyr 
65                  70                  75                  80  


Gly Cys Asp Val Glu Pro Gln Ala Leu Asn Glu Ala Ile Arg Trp Ser 
                85                  90                  95      


Ser Lys Glu Asn Leu Leu Gly Ala Thr Glu Ser Asp Pro Asn Leu Phe 
            100                 105                 110         


Val Ala Leu Tyr Asp Phe Val Ala Ser Gly Asp Asn Thr Leu Ser Ile 
        115                 120                 125             


Thr Lys Gly Glu Lys Leu Arg Val Leu Gly Tyr Asn Gln Asn Gly Glu 
    130                 135                 140                 


Trp Ser Glu Val Arg Ser Lys Asn Gly Gln Gly Trp Val Pro Ser Asn 
145                 150                 155                 160 


Tyr Ile Thr Pro Val Asn Ser Leu Glu Lys His Ser Trp Tyr His Gly 
                165                 170                 175     


Pro Val Ser Arg Ser Ala Ala Glu Tyr Leu Leu Ser Ser Leu Ile Asn 
            180                 185                 190         


Gly Ser Phe Leu Val Arg Glu Ser Glu Ser Ser Pro Gly Gln Leu Ser 
        195                 200                 205             


Ile Ser Leu Arg Tyr Glu Gly Arg Val Tyr His Tyr Arg Ile Asn Thr 
    210                 215                 220                 


Thr Ala Asp Gly Lys Val Tyr Val Thr Ala Glu Ser Arg Phe Ser Thr 
225                 230                 235                 240 


Leu Ala Glu Leu Val His His His Ser Thr Val Ala Asp Gly Leu Val 
                245                 250                 255     


Thr Thr Leu His Tyr Pro Ala Pro Lys Cys Asn Lys Pro Thr Val Tyr 
            260                 265                 270         


Gly Val Ser Pro Ile His Asp Lys Trp Glu Met Glu Arg Thr Asp Ile 
        275                 280                 285             


Thr Met Lys His Lys Leu Gly Gly Gly Gln Tyr Gly Glu Val Tyr Val 
    290                 295                 300                 


Gly Val Trp Lys Lys Tyr Ser Leu Thr Val Ala Val Lys Thr Leu Lys 
305                 310                 315                 320 


Glu Asp Thr Met Glu Val Glu Glu Phe Leu Lys Glu Ala Ala Val Met 
                325                 330                 335     


Lys Glu Ile Lys His Pro Asn Leu Val Gln Leu Leu Gly Val Cys Thr 
            340                 345                 350         


Leu Glu Pro Pro Phe Tyr Ile Val Thr Glu Tyr Met Pro Tyr Gly Asn 
        355                 360                 365             


Leu Leu Asp Tyr Leu Arg Glu Cys Asn Arg Glu Glu Val Thr Ala Val 
    370                 375                 380                 


Val Leu Leu Tyr Met Ala Thr Gln Ile Ser Ser Ala Met Glu Tyr Leu 
385                 390                 395                 400 


Glu Lys Lys Asn Phe Ile His Arg Asp Leu Ala Ala Arg Asn Cys Leu 
                405                 410                 415     


Val Gly Glu Asn His Val Val Lys Val Ala Asp Phe Gly Leu Ser Arg 
            420                 425                 430         


Leu Met Thr Gly Asp Thr Tyr Thr Ala His Ala Gly Ala Lys Phe Pro 
        435                 440                 445             


Ile Lys Trp Thr Ala Pro Glu Ser Leu Ala Tyr Asn Thr Phe Ser Ile 
    450                 455                 460                 


Lys Ser Asp Val Trp Ala Phe Gly Val Leu Leu Trp Glu Ile Ala Thr 
465                 470                 475                 480 


Tyr Gly Met Ser Pro Tyr Pro Gly Ile Asp Leu Ser Gln Val Tyr Asp 
                485                 490                 495     


Leu Leu Glu Lys Gly Tyr Arg Met Glu Gln Pro Glu Gly Cys Pro Pro 
            500                 505                 510         


Lys Val Tyr Glu Leu Met Arg Ala Cys Trp Lys Trp Ser Pro Ala Asp 
        515                 520                 525             


Arg Pro Ser Phe Ala Glu Thr His Gln Ala Phe Glu Thr Met Phe His 
    530                 535                 540                 


Asp Ser Ser Ile Ser Glu Glu Val Ala Glu Glu Leu Gly Arg Ala Ala 
545                 550                 555                 560 


Ser Ser Ser Ser Val Val Pro Tyr Leu Pro Arg Leu Pro Ile Leu Pro 
                565                 570                 575     


Ser Lys Thr Arg Thr Leu Lys Lys Gln Val Glu Asn Lys Glu Asn Ile 
            580                 585                 590         


Glu Gly Ala Gln Asp Ala Thr Glu Asn Ser Ala Ser Ser Leu Ala Pro 
        595                 600                 605             


Gly Phe Ile Arg Gly Ala Gln Ala Ser Ser Gly Ser Pro Ala Leu Pro 
    610                 615                 620                 


Arg Lys Gln Arg Asp Lys Ser Pro Ser Ser Leu Leu Glu Asp Ala Lys 
625                 630                 635                 640 


Glu Thr Cys Phe Thr Arg Asp Arg Lys Gly Gly Phe Phe Ser Ser Phe 
                645                 650                 655     


Met Lys Lys Arg Asn Ala Pro Thr Pro Pro Lys Arg Ser Ser Ser Phe 
            660                 665                 670         


Arg Glu Met Glu Asn Gln Pro His Lys Lys Tyr Glu Leu Thr Gly Asn 
        675                 680                 685             


Phe Ser Ser Val Ala Ser Leu Gln His Ala Asp Gly Phe Ser Phe Thr 
    690                 695                 700                 


Pro Ala Gln Gln Glu Ala Asn Leu Val Pro Pro Lys Cys Tyr Gly Gly 
705                 710                 715                 720 


Ser Phe Ala Gln Arg Asn Leu Cys Asn Asp Asp Gly Gly Gly Gly Gly 
                725                 730                 735     


Gly Ser Gly Thr Ala Gly Gly Gly Trp Ser Gly Ile Thr Gly Phe Phe 
            740                 745                 750         


Thr Pro Arg Leu Ile Lys Lys Thr Leu Gly Leu Arg Ala Gly Lys Pro 
        755                 760                 765             


Thr Ala Ser Asp Asp Thr Ser Lys Pro Phe Pro Arg Ser Asn Ser Thr 
    770                 775                 780                 


Ser Ser Met Ser Ser Gly Leu Pro Glu Gln Asp Arg Met Ala Met Thr 
785                 790                 795                 800 


Leu Pro Arg Asn Cys Gln Arg Ser Lys Leu Gln Leu Glu Arg Thr Val 
                805                 810                 815     


Ser Thr Ser Ser Gln Pro Glu Glu Asn Val Asp Arg Ala Asn Asp Met 
            820                 825                 830         


Leu Pro Lys Lys Ser Glu Glu Ser Ala Ala Pro Ser Arg Glu Arg Pro 
        835                 840                 845             


Lys Ala Lys Leu Leu Pro Arg Gly Ala Thr Ala Leu Pro Leu Arg Thr 
    850                 855                 860                 


Pro Ser Gly Asp Leu Ala Ile Thr Glu Lys Asp Pro Pro Gly Val Gly 
865                 870                 875                 880 


Val Ala Gly Val Ala Ala Ala Pro Lys Gly Lys Glu Lys Asn Gly Gly 
                885                 890                 895     


Ala Arg Leu Gly Met Ala Gly Val Pro Glu Asp Gly Glu Gln Pro Gly 
            900                 905                 910         


Trp Pro Ser Pro Ala Lys Ala Ala Pro Val Leu Pro Thr Thr His Asn 
        915                 920                 925             


His Lys Val Pro Val Leu Ile Ser Pro Thr Leu Lys His Thr Pro Ala 
    930                 935                 940                 


Asp Val Gln Leu Ile Gly Thr Asp Ser Gln Gly Asn Lys Phe Lys Leu 
945                 950                 955                 960 


Leu Ser Glu His Gln Val Thr Ser Ser Gly Asp Lys Asp Arg Pro Arg 
                965                 970                 975     


Arg Val Lys Pro Lys Cys Ala Pro Pro Pro Pro Pro Val Met Arg Leu 
            980                 985                 990         


Leu Gln His Pro Ser Ile Cys Ser  Asp Pro Thr Glu Glu  Pro Thr Ala 
        995                 1000                 1005             


Leu Thr  Ala Gly Gln Ser Thr  Ser Glu Thr Gln Glu  Gly Gly Lys 
    1010                 1015                 1020             


Lys Ala  Ala Leu Gly Ala Val  Pro Ile Ser Gly Lys  Ala Gly Arg 
    1025                 1030                 1035             


Pro Val  Met Pro Pro Pro Gln  Val Pro Leu Pro Thr  Ser Ser Ile 
    1040                 1045                 1050             


Ser Pro  Ala Lys Met Ala Asn  Gly Thr Ala Gly Thr  Lys Val Ala 
    1055                 1060                 1065             


Leu Arg  Lys Thr Lys Gln Ala  Ala Glu Lys Ile Ser  Ala Asp Lys 
    1070                 1075                 1080             


Ile Ser  Lys Glu Ala Leu Leu  Glu Cys Ala Asp Leu  Leu Ser Ser 
    1085                 1090                 1095             


Ala Leu  Thr Glu Pro Val Pro  Asn Ser Gln Leu Val  Asp Thr Gly 
    1100                 1105                 1110             


His Gln  Leu Leu Asp Tyr Cys  Ser Gly Tyr Val Asp  Cys Ile Pro 
    1115                 1120                 1125             


Gln Thr  Arg Asn Lys Phe Ala  Phe Arg Glu Ala Val  Ser Lys Leu 
    1130                 1135                 1140             


Glu Leu  Ser Leu Gln Glu Leu  Gln Val Ser Ser Ala  Ala Ala Gly 
    1145                 1150                 1155             


Val Pro  Gly Thr Asn Pro Val  Leu Asn Asn Leu Leu  Ser Cys Val 
    1160                 1165                 1170             


Gln Glu  Ile Ser Asp Val Val  Gln Arg 
    1175                 1180         


<210>  284
<211>  361
<212>  PRT
<213>  Homo sapiens

<400>  284

Met Ser Thr Ala Arg Glu Gln Pro Ile Phe Ser Thr Arg Ala His Val 
1               5                   10                  15      


Phe Gln Ile Asp Pro Ala Thr Lys Arg Asn Trp Ile Pro Ala Gly Lys 
            20                  25                  30          


His Ala Leu Thr Val Ser Tyr Phe Tyr Asp Ala Thr Arg Asn Val Tyr 
        35                  40                  45              


Arg Ile Ile Ser Ile Gly Gly Ala Lys Ala Ile Ile Asn Ser Thr Val 
    50                  55                  60                  


Thr Pro Asn Met Thr Phe Thr Lys Thr Ser Gln Lys Phe Gly Gln Trp 
65                  70                  75                  80  


Ala Asp Ser Arg Ala Asn Thr Val Tyr Gly Leu Gly Phe Ala Ser Glu 
                85                  90                  95      


Gln His Leu Thr Gln Phe Ala Glu Lys Phe Gln Glu Val Lys Glu Ala 
            100                 105                 110         


Ala Arg Leu Ala Arg Glu Lys Ser Gln Asp Gly Gly Glu Leu Thr Ser 
        115                 120                 125             


Pro Ala Leu Gly Leu Ala Ser His Gln Val Pro Pro Ser Pro Leu Val 
    130                 135                 140                 


Ser Ala Asn Gly Pro Gly Glu Glu Lys Leu Phe Arg Ser Gln Ser Ala 
145                 150                 155                 160 


Asp Ala Pro Gly Pro Thr Glu Arg Glu Arg Leu Lys Lys Met Leu Ser 
                165                 170                 175     


Glu Gly Ser Val Gly Glu Val Gln Trp Glu Ala Glu Phe Phe Ala Leu 
            180                 185                 190         


Gln Asp Ser Asn Asn Lys Leu Ala Gly Ala Leu Arg Glu Ala Asn Ala 
        195                 200                 205             


Ala Ala Ala Gln Trp Arg Gln Gln Leu Glu Ala Gln Arg Ala Glu Ala 
    210                 215                 220                 


Glu Arg Leu Arg Gln Arg Val Ala Glu Leu Glu Ala Gln Ala Ala Ser 
225                 230                 235                 240 


Glu Val Thr Pro Thr Gly Glu Lys Glu Gly Leu Gly Gln Gly Gln Ser 
                245                 250                 255     


Leu Glu Gln Leu Glu Ala Leu Val Gln Thr Lys Asp Gln Glu Ile Gln 
            260                 265                 270         


Thr Leu Lys Ser Gln Thr Gly Gly Pro Arg Glu Ala Leu Glu Ala Ala 
        275                 280                 285             


Glu Arg Glu Glu Thr Gln Gln Lys Val Gln Asp Leu Glu Thr Arg Asn 
    290                 295                 300                 


Ala Glu Leu Glu His Gln Leu Arg Ala Met Glu Arg Ser Leu Glu Glu 
305                 310                 315                 320 


Ala Arg Ala Glu Arg Glu Arg Ala Arg Ala Glu Val Gly Arg Ala Ala 
                325                 330                 335     


Gln Leu Leu Asp Val Ser Leu Phe Glu Leu Ser Glu Leu Arg Glu Gly 
            340                 345                 350         


Leu Ala Arg Leu Ala Glu Ala Ala Pro 
        355                 360     


<210>  285
<211>  484
<212>  PRT
<213>  Homo sapiens

<400>  285

Met Arg His Ser Lys Arg Thr Tyr Cys Pro Asp Trp Asp Asp Lys Asp 
1               5                   10                  15      


Trp Asp Tyr Gly Lys Trp Arg Ser Ser Ser Ser His Lys Arg Arg Lys 
            20                  25                  30          


Arg Ser His Ser Ser Ala Gln Glu Asn Lys Arg Cys Lys Tyr Asn His 
        35                  40                  45              


Ser Lys Met Cys Asp Ser His Tyr Leu Glu Ser Arg Ser Ile Asn Glu 
    50                  55                  60                  


Lys Asp Tyr His Ser Arg Arg Tyr Ile Asp Glu Tyr Arg Asn Asp Tyr 
65                  70                  75                  80  


Thr Gln Gly Cys Glu Pro Gly His Arg Gln Arg Asp His Glu Ser Arg 
                85                  90                  95      


Tyr Gln Asn His Ser Ser Lys Ser Ser Gly Arg Ser Gly Arg Ser Ser 
            100                 105                 110         


Tyr Lys Ser Lys His Arg Ile His His Ser Thr Ser His Arg Arg Ser 
        115                 120                 125             


His Gly Lys Ser His Arg Arg Lys Arg Thr Arg Ser Val Glu Asp Asp 
    130                 135                 140                 


Glu Glu Gly His Leu Ile Cys Gln Ser Gly Asp Val Leu Ser Ala Arg 
145                 150                 155                 160 


Tyr Glu Ile Val Asp Thr Leu Gly Glu Gly Ala Phe Gly Lys Val Val 
                165                 170                 175     


Glu Cys Ile Asp His Lys Ala Gly Gly Arg His Val Ala Val Lys Ile 
            180                 185                 190         


Val Lys Asn Val Asp Arg Tyr Cys Glu Ala Ala Arg Ser Glu Ile Gln 
        195                 200                 205             


Val Leu Glu His Leu Asn Thr Thr Asp Pro Asn Ser Thr Phe Arg Cys 
    210                 215                 220                 


Val Gln Met Leu Glu Trp Phe Glu His His Gly His Ile Cys Ile Val 
225                 230                 235                 240 


Phe Glu Leu Leu Gly Leu Ser Thr Tyr Asp Phe Ile Lys Glu Asn Gly 
                245                 250                 255     


Phe Leu Pro Phe Arg Leu Asp His Ile Arg Lys Met Ala Tyr Gln Ile 
            260                 265                 270         


Cys Lys Ser Val Asn Phe Leu His Ser Asn Lys Leu Thr His Thr Asp 
        275                 280                 285             


Leu Lys Pro Glu Asn Ile Leu Phe Val Gln Ser Asp Tyr Thr Glu Ala 
    290                 295                 300                 


Tyr Asn Pro Lys Ile Lys Arg Asp Glu Arg Thr Leu Ile Asn Pro Asp 
305                 310                 315                 320 


Ile Lys Val Val Asp Phe Gly Ser Ala Thr Tyr Asp Asp Glu His His 
                325                 330                 335     


Ser Thr Leu Val Ser Thr Arg His Tyr Arg Ala Pro Glu Val Ile Leu 
            340                 345                 350         


Ala Leu Gly Trp Ser Gln Pro Cys Asp Val Trp Ser Ile Gly Cys Ile 
        355                 360                 365             


Leu Ile Glu Tyr Tyr Leu Gly Phe Thr Val Phe Pro Thr His Asp Ser 
    370                 375                 380                 


Lys Glu His Leu Ala Met Met Glu Arg Ile Leu Gly Pro Leu Pro Lys 
385                 390                 395                 400 


His Met Ile Gln Lys Thr Arg Lys Arg Lys Tyr Phe His His Asp Arg 
                405                 410                 415     


Leu Asp Trp Asp Glu His Ser Ser Ala Gly Arg Tyr Val Ser Arg Arg 
            420                 425                 430         


Cys Lys Pro Leu Lys Glu Phe Met Leu Ser Gln Asp Val Glu His Glu 
        435                 440                 445             


Arg Leu Phe Asp Leu Ile Gln Lys Met Leu Glu Tyr Asp Pro Ala Lys 
    450                 455                 460                 


Arg Ile Thr Leu Arg Glu Ala Leu Lys His Pro Phe Phe Asp Leu Leu 
465                 470                 475                 480 


Lys Lys Ser Ile 
                


<210>  286
<211>  806
<212>  PRT
<213>  Homo sapiens

<400>  286

Met Gly Ala Pro Ala Cys Ala Leu Ala Leu Cys Val Ala Val Ala Ile 
1               5                   10                  15      


Val Ala Gly Ala Ser Ser Glu Ser Leu Gly Thr Glu Gln Arg Val Val 
            20                  25                  30          


Gly Arg Ala Ala Glu Val Pro Gly Pro Glu Pro Gly Gln Gln Glu Gln 
        35                  40                  45              


Leu Val Phe Gly Ser Gly Asp Ala Val Glu Leu Ser Cys Pro Pro Pro 
    50                  55                  60                  


Gly Gly Gly Pro Met Gly Pro Thr Val Trp Val Lys Asp Gly Thr Gly 
65                  70                  75                  80  


Leu Val Pro Ser Glu Arg Val Leu Val Gly Pro Gln Arg Leu Gln Val 
                85                  90                  95      


Leu Asn Ala Ser His Glu Asp Ser Gly Ala Tyr Ser Cys Arg Gln Arg 
            100                 105                 110         


Leu Thr Gln Arg Val Leu Cys His Phe Ser Val Arg Val Thr Asp Ala 
        115                 120                 125             


Pro Ser Ser Gly Asp Asp Glu Asp Gly Glu Asp Glu Ala Glu Asp Thr 
    130                 135                 140                 


Gly Val Asp Thr Gly Ala Pro Tyr Trp Thr Arg Pro Glu Arg Met Asp 
145                 150                 155                 160 


Lys Lys Leu Leu Ala Val Pro Ala Ala Asn Thr Val Arg Phe Arg Cys 
                165                 170                 175     


Pro Ala Ala Gly Asn Pro Thr Pro Ser Ile Ser Trp Leu Lys Asn Gly 
            180                 185                 190         


Arg Glu Phe Arg Gly Glu His Arg Ile Gly Gly Ile Lys Leu Arg His 
        195                 200                 205             


Gln Gln Trp Ser Leu Val Met Glu Ser Val Val Pro Ser Asp Arg Gly 
    210                 215                 220                 


Asn Tyr Thr Cys Val Val Glu Asn Lys Phe Gly Ser Ile Arg Gln Thr 
225                 230                 235                 240 


Tyr Thr Leu Asp Val Leu Glu Arg Ser Pro His Arg Pro Ile Leu Gln 
                245                 250                 255     


Ala Gly Leu Pro Ala Asn Gln Thr Ala Val Leu Gly Ser Asp Val Glu 
            260                 265                 270         


Phe His Cys Lys Val Tyr Ser Asp Ala Gln Pro His Ile Gln Trp Leu 
        275                 280                 285             


Lys His Val Glu Val Asn Gly Ser Lys Val Gly Pro Asp Gly Thr Pro 
    290                 295                 300                 


Tyr Val Thr Val Leu Lys Thr Ala Gly Ala Asn Thr Thr Asp Lys Glu 
305                 310                 315                 320 


Leu Glu Val Leu Ser Leu His Asn Val Thr Phe Glu Asp Ala Gly Glu 
                325                 330                 335     


Tyr Thr Cys Leu Ala Gly Asn Ser Ile Gly Phe Ser His His Ser Ala 
            340                 345                 350         


Trp Leu Val Val Leu Pro Ala Glu Glu Glu Leu Val Glu Ala Asp Glu 
        355                 360                 365             


Ala Gly Ser Val Tyr Ala Gly Ile Leu Ser Tyr Gly Val Gly Phe Phe 
    370                 375                 380                 


Leu Phe Ile Leu Val Val Ala Ala Val Thr Leu Cys Arg Leu Arg Ser 
385                 390                 395                 400 


Pro Pro Lys Lys Gly Leu Gly Ser Pro Thr Val His Lys Ile Ser Arg 
                405                 410                 415     


Phe Pro Leu Lys Arg Gln Val Ser Leu Glu Ser Asn Ala Ser Met Ser 
            420                 425                 430         


Ser Asn Thr Pro Leu Val Arg Ile Ala Arg Leu Ser Ser Gly Glu Gly 
        435                 440                 445             


Pro Thr Leu Ala Asn Val Ser Glu Leu Glu Leu Pro Ala Asp Pro Lys 
    450                 455                 460                 


Trp Glu Leu Ser Arg Ala Arg Leu Thr Leu Gly Lys Pro Leu Gly Glu 
465                 470                 475                 480 


Gly Cys Phe Gly Gln Val Val Met Ala Glu Ala Ile Gly Ile Asp Lys 
                485                 490                 495     


Asp Arg Ala Ala Lys Pro Val Thr Val Ala Val Lys Met Leu Lys Asp 
            500                 505                 510         


Asp Ala Thr Asp Lys Asp Leu Ser Asp Leu Val Ser Glu Met Glu Met 
        515                 520                 525             


Met Lys Met Ile Gly Lys His Lys Asn Ile Ile Asn Leu Leu Gly Ala 
    530                 535                 540                 


Cys Thr Gln Gly Gly Pro Leu Tyr Val Leu Val Glu Tyr Ala Ala Lys 
545                 550                 555                 560 


Gly Asn Leu Arg Glu Phe Leu Arg Ala Arg Arg Pro Pro Gly Leu Asp 
                565                 570                 575     


Tyr Ser Phe Asp Thr Cys Lys Pro Pro Glu Glu Gln Leu Thr Phe Lys 
            580                 585                 590         


Asp Leu Val Ser Cys Ala Tyr Gln Val Ala Arg Gly Met Glu Tyr Leu 
        595                 600                 605             


Ala Ser Gln Lys Cys Ile His Arg Asp Leu Ala Ala Arg Asn Val Leu 
    610                 615                 620                 


Val Thr Glu Asp Asn Val Met Lys Ile Ala Asp Phe Gly Leu Ala Arg 
625                 630                 635                 640 


Asp Val His Asn Leu Asp Tyr Tyr Lys Lys Thr Thr Asn Gly Arg Leu 
                645                 650                 655     


Pro Val Lys Trp Met Ala Pro Glu Ala Leu Phe Asp Arg Val Tyr Thr 
            660                 665                 670         


His Gln Ser Asp Val Trp Ser Phe Gly Val Leu Leu Trp Glu Ile Phe 
        675                 680                 685             


Thr Leu Gly Gly Ser Pro Tyr Pro Gly Ile Pro Val Glu Glu Leu Phe 
    690                 695                 700                 


Lys Leu Leu Lys Glu Gly His Arg Met Asp Lys Pro Ala Asn Cys Thr 
705                 710                 715                 720 


His Asp Leu Tyr Met Ile Met Arg Glu Cys Trp His Ala Ala Pro Ser 
                725                 730                 735     


Gln Arg Pro Thr Phe Lys Gln Leu Val Glu Asp Leu Asp Arg Val Leu 
            740                 745                 750         


Thr Val Thr Ser Thr Asp Glu Tyr Leu Asp Leu Ser Ala Pro Phe Glu 
        755                 760                 765             


Gln Tyr Ser Pro Gly Gly Gln Asp Thr Pro Ser Ser Ser Ser Ser Gly 
    770                 775                 780                 


Asp Asp Ser Val Phe Ala His Asp Leu Leu Pro Pro Ala Pro Pro Ser 
785                 790                 795                 800 


Ser Gly Gly Ser Arg Thr 
                805     


<210>  287
<211>  383
<212>  PRT
<213>  Homo sapiens

<400>  287

Met Asp Arg Thr Cys Glu Glu Arg Pro Ala Glu Asp Gly Ser Asp Glu 
1               5                   10                  15      


Glu Asp Pro Asp Ser Met Glu Ala Pro Thr Arg Ile Arg Asp Thr Pro 
            20                  25                  30          


Glu Asp Ile Val Leu Glu Ala Pro Ala Ser Gly Leu Ala Phe His Pro 
        35                  40                  45              


Ala Arg Asp Leu Leu Ala Ala Gly Asp Val Asp Gly Asp Val Phe Val 
    50                  55                  60                  


Phe Ser Tyr Ser Cys Gln Glu Gly Glu Thr Lys Glu Leu Trp Ser Ser 
65                  70                  75                  80  


Gly His His Leu Lys Ala Cys Arg Ala Val Ala Phe Ser Glu Asp Gly 
                85                  90                  95      


Gln Lys Leu Ile Thr Val Ser Lys Asp Lys Ala Ile His Val Leu Asp 
            100                 105                 110         


Val Glu Gln Gly Gln Leu Glu Arg Arg Val Ser Lys Ala His Gly Ala 
        115                 120                 125             


Pro Ile Asn Ser Leu Leu Leu Val Asp Glu Asn Val Leu Ala Thr Gly 
    130                 135                 140                 


Asp Asp Thr Gly Gly Ile Arg Leu Trp Asp Gln Arg Lys Glu Gly Pro 
145                 150                 155                 160 


Leu Met Asp Met Arg Gln His Glu Glu Tyr Ile Ala Asp Met Ala Leu 
                165                 170                 175     


Asp Pro Ala Lys Lys Leu Leu Leu Thr Ala Ser Gly Asp Gly Cys Leu 
            180                 185                 190         


Gly Ile Phe Asn Ile Lys Arg Arg Arg Phe Glu Leu Leu Ser Glu Pro 
        195                 200                 205             


Gln Ser Gly Asp Leu Thr Ser Val Thr Leu Met Lys Trp Gly Lys Lys 
    210                 215                 220                 


Val Ala Cys Gly Ser Ser Glu Gly Thr Ile Tyr Leu Phe Asn Trp Asn 
225                 230                 235                 240 


Gly Phe Gly Ala Thr Ser Asp Arg Phe Ala Leu Arg Ala Glu Ser Ile 
                245                 250                 255     


Asp Cys Met Val Pro Val Thr Glu Ser Leu Leu Cys Thr Gly Ser Thr 
            260                 265                 270         


Asp Gly Val Ile Arg Ala Val Asn Ile Leu Pro Asn Arg Val Val Gly 
        275                 280                 285             


Ser Val Gly Gln His Thr Gly Glu Pro Val Glu Glu Leu Ala Leu Ser 
    290                 295                 300                 


His Cys Gly Arg Phe Leu Ala Ser Ser Gly His Asp Gln Arg Leu Lys 
305                 310                 315                 320 


Phe Trp Asp Met Ala Gln Leu Arg Ala Val Val Val Asp Asp Tyr Arg 
                325                 330                 335     


Arg Arg Lys Lys Lys Gly Gly Pro Leu Arg Ala Leu Ser Ser Lys Thr 
            340                 345                 350         


Trp Ser Thr Asp Asp Phe Phe Ala Gly Leu Arg Glu Glu Gly Glu Asp 
        355                 360                 365             


Ser Met Ala Gln Glu Glu Lys Glu Glu Thr Gly Asp Asp Ser Asp 
    370                 375                 380             


<210>  288
<211>  452
<212>  PRT
<213>  Homo sapiens

<400>  288

Gly Ser Ala Ser Ala Pro Thr Leu Phe Pro Leu Val Ser Cys Glu Asn 
1               5                   10                  15      


Ser Pro Ser Asp Thr Ser Ser Val Ala Val Gly Cys Leu Ala Gln Asp 
            20                  25                  30          


Phe Leu Pro Asp Ser Ile Thr Leu Ser Trp Lys Tyr Lys Asn Asn Ser 
        35                  40                  45              


Asp Ile Ser Ser Thr Arg Gly Phe Pro Ser Val Leu Arg Gly Gly Lys 
    50                  55                  60                  


Tyr Ala Ala Thr Ser Gln Val Leu Leu Pro Ser Lys Asp Val Met Gln 
65                  70                  75                  80  


Gly Thr Asp Glu His Val Val Cys Lys Val Gln His Pro Asn Gly Asn 
                85                  90                  95      


Lys Glu Lys Asn Val Pro Leu Pro Val Ile Ala Glu Leu Pro Pro Lys 
            100                 105                 110         


Val Ser Val Phe Val Pro Pro Arg Asp Gly Phe Phe Gly Asn Pro Arg 
        115                 120                 125             


Lys Ser Lys Leu Ile Cys Gln Ala Thr Gly Phe Ser Pro Arg Gln Ile 
    130                 135                 140                 


Gln Val Ser Trp Leu Arg Glu Gly Lys Gln Val Gly Ser Gly Val Thr 
145                 150                 155                 160 


Thr Asp Gln Val Gln Ala Glu Ala Lys Glu Ser Gly Pro Thr Thr Tyr 
                165                 170                 175     


Lys Val Thr Ser Thr Leu Thr Ile Lys Glu Ser Asp Trp Leu Gly Gln 
            180                 185                 190         


Ser Met Phe Thr Cys Arg Val Asp His Arg Gly Leu Thr Phe Gln Gln 
        195                 200                 205             


Asn Ala Ser Ser Met Cys Val Pro Asp Gln Asp Thr Ala Ile Arg Val 
    210                 215                 220                 


Phe Ala Ile Pro Pro Ser Phe Ala Ser Ile Phe Leu Thr Lys Ser Thr 
225                 230                 235                 240 


Lys Leu Thr Cys Leu Val Thr Asp Leu Thr Thr Tyr Asp Ser Val Thr 
                245                 250                 255     


Ile Ser Trp Thr Arg Gln Asn Gly Glu Ala Val Lys Thr His Thr Asn 
            260                 265                 270         


Ile Ser Glu Ser His Pro Asn Ala Thr Phe Ser Ala Val Gly Glu Ala 
        275                 280                 285             


Ser Ile Cys Glu Asp Asp Trp Asn Ser Gly Glu Arg Phe Thr Cys Thr 
    290                 295                 300                 


Val Thr His Thr Asp Leu Pro Ser Pro Leu Lys Gln Thr Ile Ser Arg 
305                 310                 315                 320 


Pro Lys Gly Val Ala Leu His Arg Pro Asp Val Tyr Leu Leu Pro Pro 
                325                 330                 335     


Ala Arg Glu Gln Leu Asn Leu Arg Glu Ser Ala Thr Ile Thr Cys Leu 
            340                 345                 350         


Val Thr Gly Phe Ser Pro Ala Asp Val Phe Val Gln Trp Met Gln Arg 
        355                 360                 365             


Gly Gln Pro Leu Ser Pro Glu Lys Tyr Val Thr Ser Ala Pro Met Pro 
    370                 375                 380                 


Glu Pro Gln Ala Pro Gly Arg Tyr Phe Ala His Ser Ile Leu Thr Val 
385                 390                 395                 400 


Ser Glu Glu Glu Trp Asn Thr Gly Glu Thr Tyr Thr Cys Val Ala His 
                405                 410                 415     


Glu Ala Leu Pro Asn Arg Val Thr Glu Arg Thr Val Asp Lys Ser Thr 
            420                 425                 430         


Gly Lys Pro Thr Leu Tyr Asn Val Ser Leu Val Met Ser Asp Thr Ala 
        435                 440                 445             


Gly Thr Cys Tyr 
    450         


<210>  289
<211>  244
<212>  PRT
<213>  Homo sapiens

<400>  289

Met Met Arg Thr Gln Cys Leu Leu Gly Leu Arg Thr Phe Val Ala Phe 
1               5                   10                  15      


Ala Ala Lys Leu Trp Ser Phe Phe Ile Tyr Leu Leu Arg Arg Gln Ile 
            20                  25                  30          


Arg Thr Val Ile Gln Tyr Gln Thr Val Arg Tyr Asp Ile Leu Pro Leu 
        35                  40                  45              


Ser Pro Val Ser Arg Asn Arg Leu Ala Gln Val Lys Arg Lys Ile Leu 
    50                  55                  60                  


Val Leu Asp Leu Asp Glu Thr Leu Ile His Ser His His Asp Gly Val 
65                  70                  75                  80  


Leu Arg Pro Thr Val Arg Pro Gly Thr Pro Pro Asp Phe Ile Leu Lys 
                85                  90                  95      


Val Val Ile Asp Lys His Pro Val Arg Phe Phe Val His Lys Arg Pro 
            100                 105                 110         


His Val Asp Phe Phe Leu Glu Val Val Ser Gln Trp Tyr Glu Leu Val 
        115                 120                 125             


Val Phe Thr Ala Ser Met Glu Ile Tyr Gly Ser Ala Val Ala Asp Lys 
    130                 135                 140                 


Leu Asp Asn Ser Arg Ser Ile Leu Lys Arg Arg Tyr Tyr Arg Gln His 
145                 150                 155                 160 


Cys Thr Leu Glu Leu Gly Ser Tyr Ile Lys Asp Leu Ser Val Val His 
                165                 170                 175     


Ser Asp Leu Ser Ser Ile Val Ile Leu Asp Asn Ser Pro Gly Ala Tyr 
            180                 185                 190         


Arg Ser His Pro Asp Asn Ala Ile Pro Ile Lys Ser Trp Phe Ser Asp 
        195                 200                 205             


Pro Ser Asp Thr Ala Leu Leu Asn Leu Leu Pro Met Leu Asp Ala Leu 
    210                 215                 220                 


Arg Phe Thr Ala Asp Val Arg Ser Val Leu Ser Arg Asn Leu His Gln 
225                 230                 235                 240 


His Arg Leu Trp 
                


<210>  290
<211>  123
<212>  PRT
<213>  Homo sapiens

<400>  290

Met Asn Pro Val Tyr Ser Pro Gly Ser Ser Gly Val Pro Tyr Ala Asn 
1               5                   10                  15      


Ala Lys Gly Ile Gly Tyr Pro Ala Gly Phe Pro Met Gly Tyr Ala Ala 
            20                  25                  30          


Ala Ala Pro Ala Tyr Ser Pro Asn Met Tyr Pro Gly Ala Asn Pro Thr 
        35                  40                  45              


Phe Gln Thr Gly Tyr Thr Pro Gly Thr Pro Tyr Lys Val Ser Cys Ser 
    50                  55                  60                  


Pro Thr Ser Gly Ala Val Pro Pro Tyr Ser Ser Ser Pro Gln Ala Val 
65                  70                  75                  80  


Pro Met Ser Pro Cys Ala Asp Gln Trp Ala Arg Gln Leu Gly Gln Ile 
                85                  90                  95      


Ser Gly Gln Pro Phe Val Leu Leu Ala Gly Leu Leu Cys Trp Pro His 
            100                 105                 110         


Gly Glu Ala Leu Glu Ser Leu Met Asp Cys Asn 
        115                 120             


<210>  291
<211>  666
<212>  PRT
<213>  Homo sapiens

<400>  291

Met Glu Gln Glu Pro Gln Asn Gly Glu Pro Ala Glu Ile Lys Ile Ile 
1               5                   10                  15      


Arg Glu Ala Tyr Lys Lys Ala Phe Leu Phe Val Asn Lys Gly Leu Asn 
            20                  25                  30          


Thr Asp Glu Leu Gly Gln Lys Glu Glu Ala Lys Asn Tyr Tyr Lys Gln 
        35                  40                  45              


Gly Ile Gly His Leu Leu Arg Gly Ile Ser Ile Ser Ser Lys Glu Ser 
    50                  55                  60                  


Glu His Thr Gly Pro Gly Trp Glu Ser Ala Arg Gln Met Gln Gln Lys 
65                  70                  75                  80  


Met Lys Glu Thr Leu Gln Asn Val Arg Thr Arg Leu Glu Ile Leu Glu 
                85                  90                  95      


Lys Gly Leu Ala Thr Ser Leu Gln Asn Asp Leu Gln Glu Val Pro Lys 
            100                 105                 110         


Leu Tyr Pro Glu Phe Pro Pro Lys Asp Met Cys Glu Lys Leu Pro Glu 
        115                 120                 125             


Pro Gln Ser Phe Ser Ser Ala Pro Gln His Ala Glu Val Asn Gly Asn 
    130                 135                 140                 


Thr Ser Thr Pro Ser Ala Gly Ala Val Ala Ala Pro Ala Ser Leu Ser 
145                 150                 155                 160 


Leu Pro Ser Gln Ser Cys Pro Ala Glu Ala Pro Pro Ala Tyr Thr Pro 
                165                 170                 175     


Gln Ala Ala Glu Gly His Tyr Thr Val Ser Tyr Gly Thr Asp Ser Gly 
            180                 185                 190         


Glu Phe Ser Ser Val Gly Glu Glu Phe Tyr Arg Asn His Ser Gln Pro 
        195                 200                 205             


Pro Pro Leu Glu Thr Leu Gly Leu Asp Ala Asp Glu Leu Ile Leu Ile 
    210                 215                 220                 


Pro Asn Gly Val Gln Ile Phe Phe Val Asn Pro Ala Gly Glu Val Ser 
225                 230                 235                 240 


Ala Pro Ser Tyr Pro Gly Tyr Leu Arg Ile Val Arg Phe Leu Asp Asn 
                245                 250                 255     


Ser Leu Asp Thr Val Leu Asn Arg Pro Pro Gly Phe Leu Gln Val Cys 
            260                 265                 270         


Asp Trp Leu Tyr Pro Leu Val Pro Asp Arg Ser Pro Val Leu Lys Cys 
        275                 280                 285             


Thr Ala Gly Ala Tyr Met Phe Pro Asp Thr Met Leu Gln Ala Ala Gly 
    290                 295                 300                 


Cys Phe Val Gly Val Val Leu Ser Ser Glu Leu Pro Glu Asp Asp Arg 
305                 310                 315                 320 


Glu Leu Phe Glu Asp Leu Leu Arg Gln Met Ser Asp Leu Arg Leu Gln 
                325                 330                 335     


Ala Asn Trp Asn Arg Ala Glu Glu Glu Asn Glu Phe Gln Ile Pro Gly 
            340                 345                 350         


Arg Thr Arg Pro Ser Ser Asp Gln Leu Lys Glu Ala Ser Gly Thr Asp 
        355                 360                 365             


Val Lys Gln Leu Asp Gln Gly Asn Lys Asp Val Arg His Lys Gly Lys 
    370                 375                 380                 


Arg Gly Lys Arg Ala Lys Asp Thr Ser Ser Glu Glu Val Asn Leu Ser 
385                 390                 395                 400 


His Ile Val Pro Cys Glu Pro Val Pro Glu Glu Lys Pro Lys Glu Leu 
                405                 410                 415     


Pro Glu Trp Ser Glu Lys Val Ala His Asn Ile Leu Ser Gly Ala Ser 
            420                 425                 430         


Trp Val Ser Trp Gly Leu Val Lys Gly Ala Glu Ile Thr Gly Lys Ala 
        435                 440                 445             


Ile Gln Lys Gly Ala Ser Lys Leu Arg Glu Arg Ile Gln Pro Glu Glu 
    450                 455                 460                 


Lys Pro Val Glu Val Ser Pro Ala Val Thr Lys Gly Leu Tyr Ile Ala 
465                 470                 475                 480 


Lys Gln Ala Thr Gly Gly Ala Ala Lys Val Ser Gln Phe Leu Val Asp 
                485                 490                 495     


Gly Val Cys Thr Val Ala Asn Cys Val Gly Lys Glu Leu Ala Pro His 
            500                 505                 510         


Val Lys Lys His Gly Ser Lys Leu Val Pro Glu Ser Leu Lys Lys Asp 
        515                 520                 525             


Lys Asp Gly Lys Ser Pro Leu Asp Gly Ala Met Val Val Ala Ala Ser 
    530                 535                 540                 


Ser Val Gln Gly Phe Ser Thr Val Trp Gln Gly Leu Glu Cys Ala Ala 
545                 550                 555                 560 


Lys Cys Ile Val Asn Asn Val Ser Ala Glu Thr Val Gln Thr Val Arg 
                565                 570                 575     


Tyr Lys Tyr Gly Tyr Asn Ala Gly Glu Ala Thr His His Ala Val Asp 
            580                 585                 590         


Ser Ala Val Asn Val Gly Val Thr Ala Tyr Asn Ile Asn Asn Ile Gly 
        595                 600                 605             


Ile Lys Ala Met Val Lys Lys Thr Ala Thr Gln Thr Gly His Thr Leu 
    610                 615                 620                 


Leu Glu Asp Tyr Gln Ile Val Asp Asn Ser Gln Arg Glu Asn Gln Glu 
625                 630                 635                 640 


Gly Ala Ala Asn Val Asn Val Arg Gly Glu Lys Asp Glu Gln Thr Lys 
                645                 650                 655     


Glu Val Lys Glu Ala Lys Lys Lys Asp Lys 
            660                 665     


<210>  292
<211>  220
<212>  PRT
<213>  Homo sapiens

<400>  292

Met Ala Ser Glu Arg Leu Pro Asn Arg Pro Ala Cys Leu Leu Val Ala 
1               5                   10                  15      


Ser Gly Ala Ala Glu Gly Val Ser Ala Gln Ser Phe Leu His Cys Phe 
            20                  25                  30          


Thr Met Ala Ser Thr Ala Phe Asn Leu Gln Val Ala Thr Pro Gly Gly 
        35                  40                  45              


Lys Ala Met Glu Phe Val Asp Val Thr Glu Ser Asn Ala Arg Trp Val 
    50                  55                  60                  


Gln Asp Phe Arg Leu Lys Ala Tyr Ala Ser Pro Ala Lys Leu Glu Ser 
65                  70                  75                  80  


Ile Asp Gly Ala Arg Tyr His Ala Leu Leu Ile Pro Ser Cys Pro Gly 
                85                  90                  95      


Ala Leu Thr Asp Leu Ala Ser Ser Gly Ser Leu Ala Arg Ile Leu Gln 
            100                 105                 110         


His Phe His Ser Glu Ser Lys Pro Ile Cys Ala Val Gly His Gly Val 
        115                 120                 125             


Ala Ala Leu Cys Cys Ala Thr Asn Glu Asp Arg Ser Trp Val Phe Asp 
    130                 135                 140                 


Ser Tyr Ser Leu Thr Gly Pro Ser Val Cys Glu Leu Val Arg Ala Pro 
145                 150                 155                 160 


Gly Phe Ala Arg Leu Pro Leu Val Val Glu Asp Phe Val Lys Asp Ser 
                165                 170                 175     


Gly Ala Cys Phe Ser Ala Ser Glu Pro Asp Ala Val His Val Val Leu 
            180                 185                 190         


Asp Arg His Leu Val Thr Gly Gln Asn Ala Ser Ser Thr Val Pro Ala 
        195                 200                 205             


Val Gln Asn Leu Leu Phe Leu Cys Gly Ser Arg Lys 
    210                 215                 220 


<210>  293
<211>  354
<212>  PRT
<213>  Homo sapiens

<400>  293

Met Cys Gly Arg Thr Ser Cys His Leu Pro Arg Asp Val Leu Thr Arg 
1               5                   10                  15      


Ala Cys Ala Tyr Gln Asp Arg Arg Gly Gln Gln Arg Leu Pro Glu Trp 
            20                  25                  30          


Arg Asp Pro Asp Lys Tyr Cys Pro Ser Tyr Asn Lys Ser Pro Gln Ser 
        35                  40                  45              


Asn Ser Pro Val Leu Leu Ser Arg Leu His Phe Glu Lys Asp Ala Asp 
    50                  55                  60                  


Ser Ser Glu Arg Ile Ile Ala Pro Met Arg Trp Gly Leu Val Pro Ser 
65                  70                  75                  80  


Trp Phe Lys Glu Ser Asp Pro Ser Lys Leu Gln Phe Asn Thr Thr Asn 
                85                  90                  95      


Cys Arg Ser Asp Thr Val Met Glu Lys Arg Ser Phe Lys Val Pro Leu 
            100                 105                 110         


Gly Lys Gly Arg Arg Cys Val Val Leu Ala Asp Gly Phe Tyr Glu Trp 
        115                 120                 125             


Gln Arg Cys Gln Gly Thr Asn Gln Arg Gln Pro Tyr Phe Ile Tyr Phe 
    130                 135                 140                 


Pro Gln Ile Lys Thr Glu Lys Ser Gly Ser Ile Gly Ala Ala Asp Ser 
145                 150                 155                 160 


Pro Glu Asn Trp Glu Lys Val Trp Asp Asn Trp Arg Leu Leu Thr Met 
                165                 170                 175     


Ala Gly Ile Phe Asp Cys Trp Glu Pro Pro Glu Gly Gly Asp Val Leu 
            180                 185                 190         


Tyr Ser Tyr Thr Ile Ile Thr Val Asp Ser Cys Lys Gly Leu Ser Asp 
        195                 200                 205             


Ile His His Arg Met Pro Ala Ile Leu Asp Gly Glu Glu Ala Val Ser 
    210                 215                 220                 


Lys Trp Leu Asp Phe Gly Glu Val Ser Thr Gln Glu Ala Leu Lys Leu 
225                 230                 235                 240 


Ile His Pro Thr Glu Asn Ile Thr Phe His Ala Val Ser Ser Val Val 
                245                 250                 255     


Asn Asn Ser Arg Asn Asn Thr Pro Glu Cys Leu Ala Pro Val Asp Leu 
            260                 265                 270         


Val Val Lys Lys Glu Leu Arg Ala Ser Gly Ser Ser Gln Arg Met Leu 
        275                 280                 285             


Gln Trp Leu Ala Thr Lys Ser Pro Lys Lys Glu Asp Ser Lys Thr Pro 
    290                 295                 300                 


Gln Lys Glu Glu Ser Asp Val Pro Gln Trp Ser Ser Gln Phe Leu Gln 
305                 310                 315                 320 


Lys Ser Pro Leu Pro Thr Lys Arg Gly Thr Ala Gly Leu Leu Glu Gln 
                325                 330                 335     


Trp Leu Lys Arg Glu Lys Glu Glu Glu Pro Val Ala Lys Arg Pro Tyr 
            340                 345                 350         


Ser Gln 
        


<210>  294
<211>  268
<212>  PRT
<213>  Homo sapiens

<400>  294

Met Ser Gly Lys Ala Asn Ala Ser Lys Lys Asn Ala Gln Gln Leu Lys 
1               5                   10                  15      


Arg Asn Pro Lys Arg Lys Lys Asp Asn Glu Glu Val Val Leu Ser Glu 
            20                  25                  30          


Asn Lys Val Arg Asn Thr Val Lys Lys Asn Lys Asn His Leu Lys Asp 
        35                  40                  45              


Leu Ser Ser Glu Gly Gln Thr Lys His Thr Asn Leu Lys His Gly Lys 
    50                  55                  60                  


Thr Ala Ala Ser Lys Arg Lys Thr Trp Gln Pro Leu Ser Lys Ser Thr 
65                  70                  75                  80  


Arg Asp His Leu Gln Thr Met Met Glu Ser Val Ile Met Thr Ile Leu 
                85                  90                  95      


Ser Asn Ser Ile Lys Glu Lys Glu Glu Ile Gln Tyr His Leu Asn Phe 
            100                 105                 110         


Leu Lys Lys Arg Leu Leu Gln Gln Cys Glu Thr Leu Lys Val Pro Pro 
        115                 120                 125             


Lys Lys Met Glu Asp Leu Thr Asn Val Ser Ser Leu Leu Asn Met Glu 
    130                 135                 140                 


Arg Ala Arg Asp Lys Ala Asn Glu Glu Gly Leu Ala Leu Leu Gln Glu 
145                 150                 155                 160 


Glu Ile Asp Lys Met Val Glu Thr Thr Glu Leu Met Thr Gly Asn Ile 
                165                 170                 175     


Gln Ser Leu Lys Asn Lys Ile Gln Ile Leu Ala Ser Glu Val Glu Glu 
            180                 185                 190         


Glu Glu Glu Arg Val Lys Gln Met His Gln Ile Asn Ser Ser Gly Val 
        195                 200                 205             


Leu Ser Leu Pro Glu Leu Ser Gln Lys Thr Leu Lys Ala Pro Thr Leu 
    210                 215                 220                 


Gln Lys Glu Ile Leu Ala Leu Ile Pro Asn Gln Asn Ala Leu Leu Lys 
225                 230                 235                 240 


Asp Leu Asp Ile Leu His Asn Ser Ser Gln Met Lys Ser Met Ser Thr 
                245                 250                 255     


Phe Ile Glu Glu Ala Tyr Lys Lys Leu Asp Ala Ser 
            260                 265             


<210>  295
<211>  324
<212>  PRT
<213>  Homo sapiens

<400>  295

Met Gly Pro Trp Gly Glu Pro Glu Leu Leu Val Trp Arg Pro Glu Ala 
1               5                   10                  15      


Val Ala Ser Glu Pro Pro Val Pro Val Gly Leu Glu Val Lys Leu Gly 
            20                  25                  30          


Ala Leu Val Leu Leu Leu Val Leu Thr Leu Leu Cys Ser Leu Val Pro 
        35                  40                  45              


Ile Cys Val Leu Arg Arg Pro Gly Ala Asn His Glu Gly Ser Ala Ser 
    50                  55                  60                  


Arg Gln Lys Ala Leu Ser Leu Val Ser Cys Phe Ala Gly Gly Val Phe 
65                  70                  75                  80  


Leu Ala Thr Cys Leu Leu Asp Leu Leu Pro Asp Tyr Leu Ala Ala Ile 
                85                  90                  95      


Asp Glu Ala Leu Ala Ala Leu His Val Thr Leu Gln Phe Pro Leu Gln 
            100                 105                 110         


Glu Phe Ile Leu Ala Met Gly Phe Phe Leu Val Leu Val Met Glu Gln 
        115                 120                 125             


Ile Thr Leu Ala Tyr Lys Glu Gln Ser Gly Pro Ser Pro Leu Glu Glu 
    130                 135                 140                 


Thr Arg Ala Leu Leu Gly Thr Val Asn Gly Gly Pro Gln His Trp His 
145                 150                 155                 160 


Asp Gly Pro Gly Val Pro Gln Ala Ser Gly Ala Pro Ala Thr Pro Ser 
                165                 170                 175     


Ala Leu Arg Ala Cys Val Leu Val Phe Ser Leu Ala Leu His Ser Val 
            180                 185                 190         


Phe Glu Gly Leu Ala Val Gly Leu Gln Arg Asp Arg Ala Arg Ala Met 
        195                 200                 205             


Glu Leu Cys Leu Ala Leu Leu Leu His Lys Gly Ile Leu Ala Val Ser 
    210                 215                 220                 


Leu Ser Leu Arg Leu Leu Gln Ser His Leu Arg Ala Gln Val Val Ala 
225                 230                 235                 240 


Gly Cys Gly Ile Leu Phe Ser Cys Met Thr Pro Leu Gly Ile Gly Leu 
                245                 250                 255     


Gly Ala Ala Leu Ala Glu Ser Ala Gly Pro Leu His Gln Leu Ala Gln 
            260                 265                 270         


Ser Val Leu Glu Gly Met Ala Ala Gly Thr Phe Leu Tyr Ile Thr Phe 
        275                 280                 285             


Leu Glu Ile Leu Pro Gln Glu Leu Ala Ser Ser Glu Gln Arg Ile Leu 
    290                 295                 300                 


Lys Val Ile Leu Leu Leu Ala Gly Phe Ala Leu Leu Thr Gly Leu Leu 
305                 310                 315                 320 


Phe Ile Gln Ile 
                


<210>  296
<211>  524
<212>  PRT
<213>  Homo sapiens

<400>  296

Met Glu Leu Gly Pro Glu Pro Pro His Arg Arg Arg Leu Leu Phe Ala 
1               5                   10                  15      


Cys Ser Pro Pro Pro Ala Ser Gln Pro Val Val Lys Ala Leu Phe Gly 
            20                  25                  30          


Ala Ser Ala Ala Gly Gly Leu Ser Pro Val Thr Asn Leu Thr Val Thr 
        35                  40                  45              


Met Asp Gln Leu Gln Gly Leu Gly Ser Asp Tyr Glu Gln Pro Leu Glu 
    50                  55                  60                  


Val Lys Asn Asn Ser Asn Leu Gln Arg Met Gly Ser Ser Glu Ser Thr 
65                  70                  75                  80  


Asp Ser Gly Phe Cys Leu Asp Ser Pro Gly Pro Leu Asp Ser Lys Glu 
                85                  90                  95      


Asn Leu Glu Asn Pro Met Arg Arg Ile His Ser Leu Pro Gln Lys Leu 
            100                 105                 110         


Leu Gly Cys Ser Pro Ala Leu Lys Arg Ser His Ser Asp Ser Leu Asp 
        115                 120                 125             


His Asp Ile Phe Gln Leu Ile Asp Pro Asp Glu Asn Lys Glu Asn Glu 
    130                 135                 140                 


Ala Phe Glu Phe Lys Lys Pro Val Arg Pro Val Ser Arg Gly Cys Leu 
145                 150                 155                 160 


His Ser His Gly Leu Gln Glu Gly Lys Asp Leu Phe Thr Gln Arg Gln 
                165                 170                 175     


Asn Ser Ala Pro Ala Arg Met Leu Ser Ser Asn Glu Arg Asp Ser Ser 
            180                 185                 190         


Glu Pro Gly Asn Phe Ile Pro Leu Phe Thr Pro Gln Ser Pro Val Thr 
        195                 200                 205             


Ala Thr Leu Ser Asp Glu Asp Asp Gly Phe Val Asp Leu Leu Asp Gly 
    210                 215                 220                 


Glu Asn Leu Lys Asn Glu Glu Glu Thr Pro Ser Cys Met Ala Ser Leu 
225                 230                 235                 240 


Trp Thr Ala Pro Leu Val Met Arg Thr Thr Asn Leu Asp Asn Arg Cys 
                245                 250                 255     


Lys Leu Phe Asp Ser Pro Ser Leu Cys Ser Ser Ser Thr Arg Ser Val 
            260                 265                 270         


Leu Lys Arg Pro Glu Arg Ser Gln Glu Glu Ser Pro Pro Gly Ser Thr 
        275                 280                 285             


Lys Arg Arg Lys Ser Met Ser Gly Ala Ser Pro Lys Glu Ser Thr Asn 
    290                 295                 300                 


Pro Glu Lys Ala His Glu Thr Leu His Gln Ser Leu Ser Leu Ala Ser 
305                 310                 315                 320 


Ser Pro Lys Gly Thr Ile Glu Asn Ile Leu Asp Asn Asp Pro Arg Asp 
                325                 330                 335     


Leu Ile Gly Asp Phe Ser Lys Gly Tyr Leu Phe His Thr Val Ala Gly 
            340                 345                 350         


Lys His Gln Asp Leu Lys Tyr Ile Ser Pro Glu Ile Met Ala Ser Val 
        355                 360                 365             


Leu Asn Gly Lys Phe Ala Asn Leu Ile Lys Glu Phe Val Ile Ile Asp 
    370                 375                 380                 


Cys Arg Tyr Pro Tyr Glu Tyr Glu Gly Gly His Ile Lys Gly Ala Val 
385                 390                 395                 400 


Asn Leu His Met Glu Glu Glu Val Glu Asp Phe Leu Leu Lys Lys Pro 
                405                 410                 415     


Ile Val Pro Thr Asp Gly Lys Arg Val Ile Val Val Phe His Cys Glu 
            420                 425                 430         


Phe Ser Ser Glu Arg Gly Pro Arg Met Cys Arg Tyr Val Arg Glu Arg 
        435                 440                 445             


Asp Arg Leu Gly Asn Glu Tyr Pro Lys Leu His Tyr Pro Glu Leu Tyr 
    450                 455                 460                 


Val Leu Lys Gly Gly Tyr Lys Glu Phe Phe Met Lys Cys Gln Ser Tyr 
465                 470                 475                 480 


Cys Glu Pro Pro Ser Tyr Arg Pro Met His His Glu Asp Phe Lys Glu 
                485                 490                 495     


Asp Leu Lys Lys Phe Arg Thr Lys Ser Arg Thr Trp Ala Gly Glu Lys 
            500                 505                 510         


Ser Lys Arg Glu Met Tyr Ser Arg Leu Lys Lys Leu 
        515                 520                 


<210>  297
<211>  354
<212>  PRT
<213>  Homo sapiens

<400>  297

Met Ala Glu Ser Pro Thr Glu Glu Ala Ala Thr Ala Gly Ala Gly Ala 
1               5                   10                  15      


Ala Gly Pro Gly Ala Ser Ser Val Ala Gly Val Val Gly Val Ser Gly 
            20                  25                  30          


Ser Gly Gly Gly Phe Gly Pro Pro Phe Leu Pro Asp Val Trp Ala Ala 
        35                  40                  45              


Ala Ala Ala Ala Gly Gly Ala Gly Gly Pro Gly Ser Gly Leu Ala Pro 
    50                  55                  60                  


Leu Pro Gly Leu Pro Pro Ser Ala Ala Ala His Gly Ala Ala Leu Leu 
65                  70                  75                  80  


Ser His Trp Asp Pro Thr Leu Ser Ser Asp Trp Asp Gly Glu Arg Thr 
                85                  90                  95      


Ala Pro Gln Cys Leu Leu Arg Ile Lys Arg Asp Ile Met Ser Ile Tyr 
            100                 105                 110         


Lys Glu Pro Pro Pro Gly Met Phe Val Val Pro Asp Thr Val Asp Met 
        115                 120                 125             


Thr Lys Ile His Ala Leu Ile Thr Gly Pro Phe Asp Thr Pro Tyr Glu 
    130                 135                 140                 


Gly Gly Phe Phe Leu Phe Val Phe Arg Cys Pro Pro Asp Tyr Pro Ile 
145                 150                 155                 160 


His Pro Pro Arg Val Lys Leu Met Thr Thr Gly Asn Asn Thr Val Arg 
                165                 170                 175     


Phe Asn Pro Asn Phe Tyr Arg Asn Gly Lys Val Cys Leu Ser Ile Leu 
            180                 185                 190         


Gly Thr Trp Thr Gly Pro Ala Trp Ser Pro Ala Gln Ser Ile Ser Ser 
        195                 200                 205             


Val Leu Ile Ser Ile Gln Ser Leu Met Thr Glu Asn Pro Tyr His Asn 
    210                 215                 220                 


Glu Pro Gly Phe Glu Gln Glu Arg His Pro Gly Asp Ser Lys Asn Tyr 
225                 230                 235                 240 


Asn Glu Cys Ile Arg His Glu Thr Ile Arg Val Ala Val Cys Asp Met 
                245                 250                 255     


Met Glu Gly Lys Cys Pro Cys Pro Glu Pro Leu Arg Gly Val Met Glu 
            260                 265                 270         


Lys Ser Phe Leu Glu Tyr Tyr Asp Phe Tyr Glu Val Ala Cys Lys Asp 
        275                 280                 285             


Arg Leu His Leu Gln Gly Gln Thr Met Gln Asp Pro Phe Gly Glu Lys 
    290                 295                 300                 


Arg Gly His Phe Asp Tyr Gln Ser Leu Leu Met Arg Leu Gly Leu Ile 
305                 310                 315                 320 


Arg Gln Lys Val Leu Glu Arg Leu His Asn Glu Asn Ala Glu Met Asp 
                325                 330                 335     


Ser Asp Ser Ser Ser Ser Gly Thr Glu Thr Asp Leu His Gly Ser Leu 
            340                 345                 350         


Arg Val 
        


<210>  298
<211>  185
<212>  PRT
<213>  Homo sapiens

<400>  298

Met Ala Asp Gly Gly Gly Gly Gly Gly Thr Gly Ala Val Gly Gly Gly 
1               5                   10                  15      


Gly Thr Ser Gln Ala Ser Ala Gly Ala Ala Thr Gly Ala Thr Gly Ala 
            20                  25                  30          


Ser Gly Gly Gly Gly Pro Ile Asn Pro Ala Ser Leu Pro Pro Gly Asp 
        35                  40                  45              


Pro Gln Leu Ile Ala Leu Ile Val Glu Gln Leu Lys Ser Arg Gly Leu 
    50                  55                  60                  


Phe Asp Ser Phe Arg Arg Asp Cys Leu Ala Asp Val Asp Thr Lys Pro 
65                  70                  75                  80  


Ala Tyr Gln Asn Leu Arg Gln Lys Val Asp Asn Phe Val Ser Thr His 
                85                  90                  95      


Leu Asp Lys Gln Glu Trp Asn Pro Thr Met Asn Lys Asn Gln Leu Arg 
            100                 105                 110         


Asn Gly Leu Arg Gln Ser Val Val Gln Ser Gly Met Leu Glu Ala Gly 
        115                 120                 125             


Val Asp Arg Ile Ile Ser Gln Val Val Asp Pro Lys Leu Asn His Ile 
    130                 135                 140                 


Phe Arg Pro Gln Ile Glu Arg Ala Ile His Glu Phe Leu Ala Ala Gln 
145                 150                 155                 160 


Lys Lys Ala Ala Val Pro Ala Pro Pro Pro Glu Pro Glu Gly Gln Asp 
                165                 170                 175     


Pro Pro Ala Pro Ser Gln Asp Thr Ser 
            180                 185 


<210>  299
<211>  205
<212>  PRT
<213>  Homo sapiens

<400>  299

Met Ala Ala Ser Ser Leu Thr Val Thr Leu Gly Arg Leu Ala Ser Ala 
1               5                   10                  15      


Cys Ser His Ser Ile Leu Arg Pro Ser Gly Pro Gly Ala Ala Ser Leu 
            20                  25                  30          


Trp Ser Ala Ser Arg Arg Phe Asn Ser Gln Ser Thr Ser Tyr Leu Pro 
        35                  40                  45              


Gly Tyr Val Pro Lys Thr Ser Leu Ser Ser Pro Pro Trp Pro Glu Val 
    50                  55                  60                  


Val Leu Pro Asp Pro Val Glu Glu Thr Arg His His Ala Glu Val Val 
65                  70                  75                  80  


Lys Lys Val Asn Glu Met Ile Val Thr Gly Gln Tyr Gly Arg Leu Phe 
                85                  90                  95      


Ala Val Val His Phe Ala Ser Arg Gln Trp Lys Val Thr Ser Glu Asp 
            100                 105                 110         


Leu Ile Leu Ile Gly Asn Glu Leu Asp Leu Ala Cys Gly Glu Arg Ile 
        115                 120                 125             


Arg Leu Glu Lys Val Leu Leu Val Gly Ala Asp Asn Phe Thr Leu Leu 
    130                 135                 140                 


Gly Lys Pro Leu Leu Gly Lys Asp Leu Val Arg Val Glu Ala Thr Val 
145                 150                 155                 160 


Ile Glu Lys Thr Glu Ser Trp Pro Arg Ile Ile Met Arg Phe Arg Lys 
                165                 170                 175     


Arg Lys Asn Phe Lys Lys Lys Arg Ile Val Thr Thr Pro Gln Thr Val 
            180                 185                 190         


Leu Arg Ile Asn Ser Ile Glu Ile Ala Pro Cys Leu Leu 
        195                 200                 205 


<210>  300
<211>  507
<212>  PRT
<213>  Homo sapiens

<400>  300

Met Glu Phe Leu Leu Gly Asn Pro Phe Ser Thr Pro Val Gly Gln Cys 
1               5                   10                  15      


Leu Glu Lys Ala Thr Asp Gly Ser Leu Gln Ser Glu Asp Trp Thr Leu 
            20                  25                  30          


Asn Met Glu Ile Cys Asp Ile Ile Asn Glu Thr Glu Glu Gly Pro Lys 
        35                  40                  45              


Asp Ala Ile Arg Ala Leu Lys Lys Arg Leu Asn Gly Asn Arg Asn Tyr 
    50                  55                  60                  


Arg Glu Val Met Leu Ala Leu Thr Val Leu Glu Thr Cys Val Lys Asn 
65                  70                  75                  80  


Cys Gly His Arg Phe His Ile Leu Val Ala Asn Arg Asp Phe Ile Asp 
                85                  90                  95      


Ser Val Leu Val Lys Ile Ile Ser Pro Lys Asn Asn Pro Pro Thr Ile 
            100                 105                 110         


Val Gln Asp Lys Val Leu Ala Leu Ile Gln Ala Trp Ala Asp Ala Phe 
        115                 120                 125             


Arg Ser Ser Pro Asp Leu Thr Gly Val Val His Ile Tyr Glu Glu Leu 
    130                 135                 140                 


Lys Arg Lys Gly Val Glu Phe Pro Met Ala Asp Leu Asp Ala Leu Ser 
145                 150                 155                 160 


Pro Ile His Thr Pro Gln Arg Ser Val Pro Glu Val Asp Pro Ala Ala 
                165                 170                 175     


Thr Met Pro Arg Ser Gln Ser Gln Gln Arg Thr Ser Ala Gly Ser Tyr 
            180                 185                 190         


Ser Ser Pro Pro Pro Ala Pro Tyr Ser Ala Pro Gln Ala Pro Ala Leu 
        195                 200                 205             


Ser Val Thr Gly Pro Ile Thr Ala Asn Ser Glu Gln Ile Ala Arg Leu 
    210                 215                 220                 


Arg Ser Glu Leu Asp Val Val Arg Gly Asn Thr Lys Val Met Ser Glu 
225                 230                 235                 240 


Met Leu Thr Glu Met Val Pro Gly Gln Glu Asp Ser Ser Asp Leu Glu 
                245                 250                 255     


Leu Leu Gln Glu Leu Asn Arg Thr Cys Arg Ala Met Gln Gln Arg Ile 
            260                 265                 270         


Val Glu Leu Ile Ser Arg Val Ser Asn Glu Glu Val Thr Glu Glu Leu 
        275                 280                 285             


Leu His Val Asn Asp Asp Leu Asn Asn Val Phe Leu Arg Tyr Glu Arg 
    290                 295                 300                 


Phe Glu Arg Tyr Arg Ser Gly Arg Ser Val Gln Asn Ala Ser Asn Gly 
305                 310                 315                 320 


Val Leu Asn Glu Val Thr Glu Asp Asn Leu Ile Asp Leu Gly Pro Gly 
                325                 330                 335     


Ser Pro Ala Val Val Ser Pro Met Val Gly Asn Thr Ala Pro Pro Ser 
            340                 345                 350         


Ser Leu Ser Ser Gln Leu Ala Gly Leu Asp Leu Gly Thr Glu Ser Val 
        355                 360                 365             


Ser Gly Thr Leu Ser Ser Leu Gln Gln Cys Asn Pro Arg Asp Gly Phe 
    370                 375                 380                 


Asp Met Phe Ala Gln Thr Arg Gly Asn Ser Leu Ala Glu Gln Arg Lys 
385                 390                 395                 400 


Thr Val Thr Tyr Glu Asp Pro Gln Ala Val Gly Gly Leu Ala Ser Ala 
                405                 410                 415     


Leu Asp Asn Arg Lys Gln Ser Ser Glu Gly Ile Pro Val Ala Gln Pro 
            420                 425                 430         


Ser Val Met Asp Asp Ile Glu Val Trp Leu Arg Thr Asp Leu Lys Gly 
        435                 440                 445             


Asp Asp Leu Glu Glu Gly Val Thr Ser Glu Glu Phe Asp Lys Phe Leu 
    450                 455                 460                 


Glu Glu Arg Ala Lys Ala Ala Glu Met Val Pro Asp Leu Pro Ser Pro 
465                 470                 475                 480 


Pro Met Glu Ala Pro Ala Pro Ala Ser Asn Pro Ser Gly Arg Lys Lys 
                485                 490                 495     


Pro Glu Arg Ser Glu Asp Ala Leu Phe Ala Leu 
            500                 505         


<210>  301
<211>  392
<212>  PRT
<213>  Homo sapiens

<400>  301

Met Ser Ala Gln Ala Gln Met Arg Ala Met Leu Asp Gln Leu Met Gly 
1               5                   10                  15      


Thr Ser Arg Asp Gly Asp Thr Thr Arg Gln Arg Ile Lys Phe Ser Asp 
            20                  25                  30          


Asp Arg Val Cys Lys Ser His Leu Leu Asn Cys Cys Pro His Asp Val 
        35                  40                  45              


Leu Ser Gly Thr Arg Met Asp Leu Gly Glu Cys Leu Lys Val His Asp 
    50                  55                  60                  


Leu Ala Leu Arg Ala Asp Tyr Glu Ile Ala Ser Lys Glu Gln Asp Phe 
65                  70                  75                  80  


Phe Phe Glu Leu Asp Ala Met Asp His Leu Gln Ser Phe Ile Ala Asp 
                85                  90                  95      


Cys Asp Arg Arg Thr Glu Val Ala Lys Lys Arg Leu Ala Glu Thr Gln 
            100                 105                 110         


Glu Glu Ile Ser Ala Glu Val Ala Ala Lys Ala Glu Arg Val His Glu 
        115                 120                 125             


Leu Asn Glu Glu Ile Gly Lys Leu Leu Ala Lys Val Glu Gln Leu Gly 
    130                 135                 140                 


Ala Glu Gly Asn Val Glu Glu Ser Gln Lys Val Met Asp Glu Val Glu 
145                 150                 155                 160 


Lys Ala Arg Ala Lys Lys Arg Glu Ala Glu Glu Val Tyr Arg Asn Ser 
                165                 170                 175     


Met Pro Ala Ser Ser Phe Gln Gln Gln Lys Leu Arg Val Cys Glu Val 
            180                 185                 190         


Cys Ser Ala Tyr Leu Gly Leu His Asp Asn Asp Arg Arg Leu Ala Asp 
        195                 200                 205             


His Phe Gly Gly Lys Leu His Leu Gly Phe Ile Glu Ile Arg Glu Lys 
    210                 215                 220                 


Leu Glu Glu Leu Lys Arg Val Val Ala Glu Lys Gln Glu Lys Arg Asn 
225                 230                 235                 240 


Gln Glu Arg Leu Lys Arg Arg Glu Glu Arg Glu Arg Glu Glu Arg Glu 
                245                 250                 255     


Lys Leu Arg Arg Ser Arg Ser His Ser Lys Asn Pro Lys Arg Ser Arg 
            260                 265                 270         


Ser Arg Glu His Arg Arg His Arg Ser Arg Ser Met Ser Arg Glu Arg 
        275                 280                 285             


Lys Arg Arg Thr Arg Ser Lys Ser Arg Glu Lys Arg His Arg His Arg 
    290                 295                 300                 


Ser Arg Ser Ser Ser Arg Ser Arg Ser Arg Ser His Gln Arg Ser Arg 
305                 310                 315                 320 


His Ser Ser Arg Asp Arg Ser Arg Glu Arg Ser Lys Arg Arg Ser Ser 
                325                 330                 335     


Lys Glu Arg Phe Arg Asp Gln Asp Leu Ala Ser Cys Asp Arg Asp Arg 
            340                 345                 350         


Ser Ser Arg Asp Arg Ser Pro Arg Asp Arg Asp Arg Lys Asp Lys Lys 
        355                 360                 365             


Arg Ser Tyr Glu Ser Ala Asn Gly Arg Ser Glu Asp Arg Arg Ser Ser 
    370                 375                 380                 


Glu Glu Arg Glu Ala Gly Glu Ile 
385                 390         


<210>  302
<211>  616
<212>  PRT
<213>  Homo sapiens

<400>  302

Met Ser Thr Ile Gln Ser Glu Thr Asp Cys Tyr Asp Ile Ile Glu Val 
1               5                   10                  15      


Leu Gly Lys Gly Thr Phe Gly Glu Val Ala Lys Gly Trp Arg Arg Ser 
            20                  25                  30          


Thr Gly Glu Met Val Ala Ile Lys Ile Leu Lys Asn Asp Ala Tyr Arg 
        35                  40                  45              


Asn Arg Ile Ile Lys Asn Glu Leu Lys Leu Leu His Cys Met Arg Gly 
    50                  55                  60                  


Leu Asp Pro Glu Glu Ala His Val Ile Arg Phe Leu Glu Phe Phe His 
65                  70                  75                  80  


Asp Ala Leu Lys Phe Tyr Leu Val Phe Glu Leu Leu Glu Gln Asn Leu 
                85                  90                  95      


Phe Glu Phe Gln Lys Glu Asn Asn Phe Ala Pro Leu Pro Ala Arg His 
            100                 105                 110         


Ile Arg Thr Val Thr Leu Gln Val Leu Thr Ala Leu Ala Arg Leu Lys 
        115                 120                 125             


Glu Leu Ala Ile Ile His Ala Asp Leu Lys Pro Glu Asn Ile Met Leu 
    130                 135                 140                 


Val Asp Gln Thr Arg Cys Pro Phe Arg Val Lys Val Ile Asp Phe Gly 
145                 150                 155                 160 


Ser Ala Ser Ile Phe Ser Glu Val Arg Tyr Val Lys Glu Pro Tyr Ile 
                165                 170                 175     


Gln Ser Arg Phe Tyr Arg Ala Pro Glu Ile Leu Leu Gly Leu Pro Phe 
            180                 185                 190         


Cys Glu Lys Val Asp Val Trp Ser Leu Gly Cys Val Met Ala Glu Leu 
        195                 200                 205             


His Leu Gly Trp Pro Leu Tyr Pro Gly Asn Asn Glu Tyr Asp Gln Val 
    210                 215                 220                 


Arg Tyr Ile Cys Glu Thr Gln Gly Leu Pro Lys Pro His Leu Leu His 
225                 230                 235                 240 


Ala Ala Cys Lys Ala His His Phe Phe Lys Arg Asn Pro His Pro Asp 
                245                 250                 255     


Ala Ala Asn Pro Trp Gln Leu Lys Ser Ser Ala Asp Tyr Leu Ala Glu 
            260                 265                 270         


Thr Lys Val Arg Pro Leu Glu Arg Arg Lys Tyr Met Leu Lys Ser Leu 
        275                 280                 285             


Asp Gln Ile Glu Thr Val Asn Gly Gly Ser Val Ala Ser Arg Leu Thr 
    290                 295                 300                 


Phe Pro Asp Arg Glu Ala Leu Ala Glu His Ala Asp Leu Lys Ser Met 
305                 310                 315                 320 


Val Glu Leu Ile Lys Arg Met Leu Thr Trp Glu Ser His Glu Arg Ile 
                325                 330                 335     


Ser Pro Ser Ala Ala Leu Arg His Pro Phe Val Ser Met Gln Gln Leu 
            340                 345                 350         


Arg Ser Ala His Glu Thr Thr His Tyr Tyr Gln Leu Ser Leu Arg Ser 
        355                 360                 365             


Tyr Arg Leu Ser Leu Gln Val Glu Gly Lys Pro Pro Thr Pro Val Val 
    370                 375                 380                 


Ala Ala Glu Asp Gly Thr Pro Tyr Tyr Cys Leu Ala Glu Glu Lys Glu 
385                 390                 395                 400 


Ala Ala Gly Met Gly Ser Val Ala Gly Ser Ser Pro Phe Phe Arg Glu 
                405                 410                 415     


Glu Lys Ala Pro Gly Met Gln Arg Ala Ile Asp Gln Leu Asp Asp Leu 
            420                 425                 430         


Ser Leu Gln Glu Ala Gly His Gly Leu Trp Gly Glu Thr Cys Thr Asn 
        435                 440                 445             


Ala Val Ser Asp Met Met Val Pro Leu Lys Ala Ala Ile Thr Gly His 
    450                 455                 460                 


His Val Pro Asp Ser Gly Pro Glu Pro Ile Leu Ala Phe Tyr Ser Ser 
465                 470                 475                 480 


Arg Leu Ala Gly Arg His Lys Ala Arg Lys Pro Pro Ala Gly Ser Lys 
                485                 490                 495     


Ser Asp Ser Asn Phe Ser Asn Leu Ile Arg Leu Ser Gln Val Ser Pro 
            500                 505                 510         


Glu Asp Asp Arg Pro Cys Arg Gly Ser Ser Trp Glu Glu Gly Glu His 
        515                 520                 525             


Leu Gly Ala Ser Ala Glu Pro Leu Ala Ile Leu Gln Arg Asp Glu Asp 
    530                 535                 540                 


Gly Pro Asn Ile Asp Asn Met Thr Met Glu Ala Glu Arg Pro Asp Pro 
545                 550                 555                 560 


Glu Leu Phe Asp Pro Ser Ser Cys Pro Gly Glu Trp Leu Ser Glu Pro 
                565                 570                 575     


Asp Cys Thr Leu Glu Ser Val Arg Gly Pro Arg Ala Gln Gly Leu Pro 
            580                 585                 590         


Pro Arg Arg Ser His Gln His Gly Pro Pro Arg Gly Ala Thr Ser Phe 
        595                 600                 605             


Leu Gln His Val Thr Gly His His 
    610                 615     


<210>  303
<211>  381
<212>  PRT
<213>  Homo sapiens

<400>  303

Met Glu Ser Gly Ser Thr Ala Ala Ser Glu Glu Ala Arg Ser Leu Arg 
1               5                   10                  15      


Glu Cys Glu Leu Tyr Val Gln Lys His Asn Ile Gln Ala Leu Leu Lys 
            20                  25                  30          


Asp Ser Ile Val Gln Leu Cys Thr Ala Arg Pro Glu Arg Pro Met Ala 
        35                  40                  45              


Phe Leu Arg Glu Tyr Phe Glu Arg Leu Glu Lys Glu Glu Ala Lys Gln 
    50                  55                  60                  


Ile Gln Asn Leu Gln Lys Ala Gly Thr Arg Thr Asp Ser Arg Glu Asp 
65                  70                  75                  80  


Glu Ile Ser Pro Pro Pro Pro Asn Pro Val Val Lys Gly Arg Arg Arg 
                85                  90                  95      


Arg Gly Ala Ile Ser Ala Glu Val Tyr Thr Glu Glu Asp Ala Ala Ser 
            100                 105                 110         


Tyr Val Arg Lys Val Ile Pro Lys Asp Tyr Lys Thr Met Ala Ala Leu 
        115                 120                 125             


Ala Lys Ala Ile Glu Lys Asn Val Leu Phe Ser His Leu Asp Asp Asn 
    130                 135                 140                 


Glu Arg Ser Asp Ile Phe Asp Ala Met Phe Ser Val Ser Phe Ile Ala 
145                 150                 155                 160 


Gly Glu Thr Val Ile Gln Gln Gly Asp Glu Gly Asp Asn Phe Tyr Val 
                165                 170                 175     


Ile Asp Gln Gly Glu Thr Asp Val Tyr Val Asn Asn Glu Trp Ala Thr 
            180                 185                 190         


Ser Val Gly Glu Gly Gly Ser Phe Gly Glu Leu Ala Leu Ile Tyr Gly 
        195                 200                 205             


Thr Pro Arg Ala Ala Thr Val Lys Ala Lys Thr Asn Val Lys Leu Trp 
    210                 215                 220                 


Gly Ile Asp Arg Asp Ser Tyr Arg Arg Ile Leu Met Gly Ser Thr Leu 
225                 230                 235                 240 


Arg Lys Arg Lys Met Tyr Glu Glu Phe Leu Ser Lys Val Ser Ile Leu 
                245                 250                 255     


Glu Ser Leu Asp Lys Trp Glu Arg Leu Thr Val Ala Asp Ala Leu Glu 
            260                 265                 270         


Pro Val Gln Phe Glu Asp Gly Gln Lys Ile Val Val Gln Gly Glu Pro 
        275                 280                 285             


Gly Asp Glu Phe Phe Ile Ile Leu Glu Gly Ser Ala Ala Val Leu Gln 
    290                 295                 300                 


Arg Arg Ser Glu Asn Glu Glu Phe Val Glu Val Gly Arg Leu Gly Pro 
305                 310                 315                 320 


Ser Asp Tyr Phe Gly Glu Ile Ala Leu Leu Met Asn Arg Pro Arg Ala 
                325                 330                 335     


Ala Thr Val Val Ala Arg Gly Pro Leu Lys Cys Val Lys Leu Asp Arg 
            340                 345                 350         


Pro Arg Phe Glu Arg Val Leu Gly Pro Cys Ser Asp Ile Leu Lys Arg 
        355                 360                 365             


Asn Ile Gln Gln Tyr Asn Ser Phe Val Ser Leu Ser Val 
    370                 375                 380     


<210>  304
<211>  519
<212>  PRT
<213>  Homo sapiens

<400>  304

Met Glu Trp Lys Leu Glu Arg Thr Ala Pro Arg Arg Val Arg Thr Glu 
1               5                   10                  15      


Glu Glu Met Leu Trp Glu Ser Ile Met Arg Val Leu Ser Lys Asp Leu 
            20                  25                  30          


Lys Gln Lys Arg Ser Gln Asp Ser Ala Asn Val Leu Asp Ser Val Asn 
        35                  40                  45              


Ala Thr Tyr Ser Asp Phe Lys Ser Asn Phe Ala Lys Arg Leu Ser Ala 
    50                  55                  60                  


Glu Val Pro Val Ala Ser Ser Pro Ile Thr Thr Arg Trp Gln Gln Ser 
65                  70                  75                  80  


Gln Thr Arg Ala Leu Ser Ser Asp Ser Phe Gly Glu Glu Gln Ser Thr 
                85                  90                  95      


Thr Tyr Leu Pro Glu Ala Ser Gly Ser Val Leu Lys Thr Pro Pro Glu 
            100                 105                 110         


Lys Glu Thr Leu Thr Leu Gly Ser Cys Lys Glu Gln Leu Lys Thr Pro 
        115                 120                 125             


Ser Lys Gly Ile Ser Glu Thr Ser Asn Ser Ala Leu His Phe Cys Lys 
    130                 135                 140                 


Ala Pro His Ala Met Asp Arg Asp Trp Lys Glu Ser Val Ala Ser Lys 
145                 150                 155                 160 


Gly Gln Lys Cys Leu Lys Gln Leu Phe Val Thr Gln Asn Val Val Gln 
                165                 170                 175     


Gln Ala Asn Gly Lys Met Gln Leu Cys Glu Gln Ser Glu Cys Val Trp 
            180                 185                 190         


Lys Gly Cys Lys Asp Gly Val Arg Asp Glu Ser Phe His Leu Lys Ser 
        195                 200                 205             


Ser Gly Asp Ile Asn Asp Ser Ile Leu Gln Pro Glu Val Lys Ile His 
    210                 215                 220                 


Ile Thr Gly Leu Arg Asn Asp Tyr Tyr Leu Asn Ile Leu Asp Trp Ser 
225                 230                 235                 240 


Phe Gln Asn Leu Val Ala Ile Ala Leu Gly Ser Ala Val Tyr Ile Trp 
                245                 250                 255     


Asn Gly Glu Asn His Asn Gly Ile Glu Asn Ile Asp Leu Ser Leu Thr 
            260                 265                 270         


Cys Asn Tyr Ile Ser Ser Val Ser Trp Ile Lys Glu Gly Thr Cys Leu 
        275                 280                 285             


Ala Val Gly Thr Ser Glu Gly Glu Val Gln Leu Trp Asp Val Val Thr 
    290                 295                 300                 


Lys Lys Arg Leu Arg Asn Met Leu Gly His Leu Ser Val Val Gly Ala 
305                 310                 315                 320 


Leu Ser Trp Asn His Phe Ile Leu Ser Ser Gly Ser Arg Leu Gly Arg 
                325                 330                 335     


Val Tyr His His Asp Val Arg Val Ala Gln His His Val Gly Thr Leu 
            340                 345                 350         


Arg His Lys Gln Ala Val Cys Ala Leu Lys Trp Ser Pro Asp Gly Arg 
        355                 360                 365             


Leu Leu Ser Ser Gly Cys Ser Asp Gly Leu Leu Thr Ile Trp Pro His 
    370                 375                 380                 


Asp Pro Gly Ala Ser Ala Gln Gly Gln Pro Leu Lys Val Ile Thr Gln 
385                 390                 395                 400 


Ser Thr Ala Val Lys Ala Met Asp Trp Cys Pro Trp Gln Ser Gly Val 
                405                 410                 415     


Leu Ala Ile Gly Gly Gly Met Lys Asp Gly Arg Leu His Ile Leu Asp 
            420                 425                 430         


Ile Asn Ala Gly Lys Ser Ile Gln Thr Pro Ser Thr Asn Ser Gln Ile 
        435                 440                 445             


Cys Ser Leu Ile Trp Leu Pro Lys Thr Lys Glu Ile Ala Thr Gly Gln 
    450                 455                 460                 


Gly Thr Pro Lys Asn Asp Val Thr Val Trp Thr Cys Pro Thr Val Ser 
465                 470                 475                 480 


Arg Ser Gly Gly Phe Phe Gly His Arg Gly Arg Val Leu His Leu Ala 
                485                 490                 495     


Leu Ser Pro Asp Gln Thr Arg Val Phe Ser Ala Ala Ala Asp Gly Thr 
            500                 505                 510         


Ala Ser Val Trp Asn Cys Tyr 
        515                 


<210>  305
<211>  109
<212>  PRT
<213>  Homo sapiens

<400>  305

Met Glu Pro Asn Ser Pro Lys Lys Ile Gln Phe Ala Val Pro Val Phe 
1               5                   10                  15      


Gln Ser Gln Ile Ala Pro Glu Ala Ala Glu Gln Ile Arg Lys Arg Arg 
            20                  25                  30          


Pro Thr Pro Ala Ser Leu Val Ile Leu Asn Glu His Asn Pro Pro Glu 
        35                  40                  45              


Ile Asp Asp Lys Arg Gly Pro Asn Thr Gln Gly Glu Leu Gln Asn Ala 
    50                  55                  60                  


Ser Pro Lys Gln Arg Lys Gln Ser Val Tyr Thr Pro Pro Thr Ile Lys 
65                  70                  75                  80  


Gly Val Lys His Leu Lys Gly Gln Asn Glu Ser Ala Phe Pro Glu Glu 
                85                  90                  95      


Glu Glu Gly Thr Asn Glu Arg Glu Glu Gln Arg Asp His 
            100                 105                 


<210>  306
<211>  400
<212>  PRT
<213>  Homo sapiens

<400>  306

Met Arg Gly Arg Arg Gly Asp Arg Met Thr Ile Asn Ile Gln Glu His 
1               5                   10                  15      


Met Ala Ile Asn Val Cys Pro Gly Pro Ile Arg Pro Ile Arg Gln Ile 
            20                  25                  30          


Ser Asp Tyr Phe Pro Arg Gly Pro Gly Pro Glu Gly Gly Gly Gly Gly 
        35                  40                  45              


Gly Gly Glu Ala Pro Ala His Leu Val Pro Leu Ala Leu Ala Pro Pro 
    50                  55                  60                  


Ala Ala Leu Leu Gly Ala Thr Thr Pro Glu Asp Gly Ala Glu Val Asp 
65                  70                  75                  80  


Ser Tyr Asp Ser Asp Asp Ala Thr Ala Leu Gly Thr Leu Glu Phe Asp 
                85                  90                  95      


Leu Leu Tyr Asp Arg Ala Ser Cys Thr Leu His Cys Ser Ile Leu Arg 
            100                 105                 110         


Ala Lys Gly Leu Lys Pro Met Asp Phe Asn Gly Leu Ala Asp Pro Tyr 
        115                 120                 125             


Val Lys Leu His Leu Leu Pro Gly Ala Cys Lys Ala Asn Lys Leu Lys 
    130                 135                 140                 


Thr Lys Thr Gln Arg Asn Thr Leu Asn Pro Val Trp Asn Glu Asp Leu 
145                 150                 155                 160 


Thr Tyr Ser Gly Ile Thr Asp Asp Asp Ile Thr His Lys Val Leu Arg 
                165                 170                 175     


Ile Ala Val Cys Asp Glu Asp Lys Leu Ser His Asn Glu Phe Ile Gly 
            180                 185                 190         


Glu Ile Arg Val Pro Leu Arg Arg Leu Lys Pro Ser Gln Lys Lys His 
        195                 200                 205             


Phe Asn Ile Cys Leu Glu Arg Gln Val Pro Leu Ala Ser Pro Ser Ser 
    210                 215                 220                 


Met Ser Ala Ala Leu Arg Gly Ile Ser Cys Tyr Leu Lys Glu Leu Glu 
225                 230                 235                 240 


Gln Ala Glu Gln Gly Gln Gly Leu Leu Glu Glu Arg Gly Arg Ile Leu 
                245                 250                 255     


Leu Ser Leu Ser Tyr Ser Ser Arg Arg Arg Gly Leu Leu Val Gly Ile 
            260                 265                 270         


Leu Arg Cys Ala His Leu Ala Ala Met Asp Val Asn Gly Tyr Ser Asp 
        275                 280                 285             


Pro Tyr Val Lys Thr Tyr Leu Arg Pro Asp Val Asp Lys Lys Ser Lys 
    290                 295                 300                 


His Lys Thr Cys Val Lys Lys Lys Thr Leu Asn Pro Glu Phe Asn Glu 
305                 310                 315                 320 


Glu Phe Phe Tyr Glu Ile Glu Leu Ser Thr Leu Ala Thr Lys Thr Leu 
                325                 330                 335     


Glu Val Thr Val Trp Asp Tyr Asp Ile Gly Lys Ser Asn Asp Phe Ile 
            340                 345                 350         


Gly Gly Val Ser Leu Gly Pro Gly Ala Arg Gly Glu Ala Arg Lys His 
        355                 360                 365             


Trp Ser Asp Cys Leu Gln Gln Pro Asp Ala Ala Leu Glu Arg Trp His 
    370                 375                 380                 


Thr Leu Thr Ser Glu Leu Pro Pro Ala Ala Gly Ala Leu Ser Ser Ala 
385                 390                 395                 400 


<210>  307
<211>  394
<212>  PRT
<213>  Homo sapiens

<400>  307

Met Ser Trp Ala Ala Val Leu Ala Val Ala Ala Ala Arg Phe Gly His 
1               5                   10                  15      


Phe Trp Gly Cys Arg Trp Pro Gly Pro Met Ala Gln Gly Trp Ala Gly 
            20                  25                  30          


Phe Ser Glu Glu Glu Leu Arg Arg Leu Lys Gln Thr Lys Asp Pro Phe 
        35                  40                  45              


Glu Pro Gln Arg Arg Leu Pro Ala Lys Lys Ser Arg Gln Gln Leu Gln 
    50                  55                  60                  


Arg Glu Lys Ala Leu Val Glu Gln Ser Gln Lys Leu Gly Leu Gln Asp 
65                  70                  75                  80  


Gly Ser Thr Ser Leu Leu Pro Glu Gln Leu Leu Ser Ala Pro Lys Gln 
                85                  90                  95      


Arg Val Asn Val Gln Lys Pro Pro Phe Ser Ser Pro Thr Leu Pro Ser 
            100                 105                 110         


His Phe Thr Leu Thr Ser Pro Val Gly Asp Gly Gln Pro Gln Gly Ile 
        115                 120                 125             


Glu Ser Gln Pro Lys Glu Leu Gly Leu Glu Asn Ser His Asp Gly His 
    130                 135                 140                 


Asn Asn Val Glu Ile Leu Pro Pro Lys Pro Asp Cys Lys Leu Glu Lys 
145                 150                 155                 160 


Lys Lys Val Glu Leu Gln Glu Lys Ser Arg Trp Glu Val Leu Gln Gln 
                165                 170                 175     


Glu Gln Arg Leu Met Glu Glu Lys Asn Lys Arg Lys Lys Ala Leu Leu 
            180                 185                 190         


Ala Lys Ala Ile Ala Glu Arg Ser Lys Arg Thr Gln Ala Glu Thr Met 
        195                 200                 205             


Lys Leu Lys Arg Ile Gln Lys Glu Leu Gln Ala Leu Asp Asp Met Val 
    210                 215                 220                 


Ser Ala Asp Ile Gly Ile Leu Arg Asn Arg Ile Asp Gln Ala Ser Leu 
225                 230                 235                 240 


Asp Tyr Ser Tyr Ala Arg Lys Arg Phe Asp Arg Ala Glu Ala Glu Tyr 
                245                 250                 255     


Ile Ala Ala Lys Leu Asp Ile Gln Arg Lys Thr Glu Ile Lys Glu Gln 
            260                 265                 270         


Leu Thr Glu His Leu Cys Thr Ile Ile Gln Gln Asn Glu Leu Arg Lys 
        275                 280                 285             


Ala Lys Lys Leu Glu Glu Leu Met Gln Gln Leu Asp Val Glu Ala Asp 
    290                 295                 300                 


Glu Glu Thr Leu Glu Leu Glu Val Glu Val Glu Arg Leu Leu His Glu 
305                 310                 315                 320 


Gln Glu Val Glu Ser Arg Arg Pro Val Val Arg Leu Glu Arg Pro Phe 
                325                 330                 335     


Gln Pro Ala Glu Glu Ser Val Thr Leu Glu Phe Ala Lys Glu Asn Arg 
            340                 345                 350         


Lys Cys Gln Glu Gln Ala Val Ser Pro Lys Val Asp Asp Gln Cys Gly 
        355                 360                 365             


Asn Ser Ser Ser Ile Pro Phe Leu Ser Pro Asn Cys Pro Asn Gln Glu 
    370                 375                 380                 


Gly Asn Asp Ile Ser Ala Ala Leu Ala Thr 
385                 390                 


<210>  308
<211>  350
<212>  PRT
<213>  Homo sapiens

<400>  308

Met Leu Gly Ser Val Lys Met Glu Ala His Asp Leu Ala Glu Trp Ser 
1               5                   10                  15      


Tyr Tyr Pro Glu Ala Gly Glu Val Tyr Ser Pro Val Thr Pro Val Pro 
            20                  25                  30          


Thr Met Ala Pro Leu Asn Ser Tyr Met Thr Leu Asn Pro Leu Ser Ser 
        35                  40                  45              


Pro Tyr Pro Pro Gly Gly Leu Pro Ala Ser Pro Leu Pro Ser Gly Pro 
    50                  55                  60                  


Leu Ala Pro Pro Ala Pro Ala Ala Pro Leu Gly Pro Thr Phe Pro Gly 
65                  70                  75                  80  


Leu Gly Val Ser Gly Gly Ser Ser Ser Ser Gly Tyr Gly Ala Pro Gly 
                85                  90                  95      


Pro Gly Leu Val His Gly Lys Glu Met Pro Lys Gly Tyr Arg Arg Pro 
            100                 105                 110         


Leu Ala His Ala Lys Pro Pro Tyr Ser Tyr Ile Ser Leu Ile Thr Met 
        115                 120                 125             


Ala Ile Gln Gln Ala Pro Gly Lys Met Leu Thr Leu Ser Glu Ile Tyr 
    130                 135                 140                 


Gln Trp Ile Met Asp Leu Phe Pro Tyr Tyr Arg Glu Asn Gln Gln Arg 
145                 150                 155                 160 


Trp Gln Asn Ser Ile Arg His Ser Leu Ser Phe Asn Asp Cys Phe Val 
                165                 170                 175     


Lys Val Ala Arg Ser Pro Asp Lys Pro Gly Lys Gly Ser Tyr Trp Ala 
            180                 185                 190         


Leu His Pro Ser Ser Gly Asn Met Phe Glu Asn Gly Cys Tyr Leu Arg 
        195                 200                 205             


Arg Gln Lys Arg Phe Lys Leu Glu Glu Lys Val Lys Lys Gly Gly Ser 
    210                 215                 220                 


Gly Ala Ala Thr Thr Thr Arg Asn Gly Thr Gly Ser Ala Ala Ser Thr 
225                 230                 235                 240 


Thr Thr Pro Ala Ala Thr Val Thr Ser Pro Pro Gln Pro Pro Pro Pro 
                245                 250                 255     


Ala Pro Glu Pro Glu Ala Gln Gly Gly Glu Asp Val Gly Ala Leu Asp 
            260                 265                 270         


Cys Gly Ser Pro Ala Ser Ser Thr Pro Tyr Phe Thr Gly Leu Glu Leu 
        275                 280                 285             


Pro Gly Glu Leu Lys Leu Asp Ala Pro Tyr Asn Phe Asn His Pro Phe 
    290                 295                 300                 


Ser Ile Asn Asn Leu Met Ser Glu Gln Thr Pro Ala Pro Pro Lys Leu 
305                 310                 315                 320 


Asp Val Gly Phe Gly Gly Tyr Gly Ala Glu Gly Gly Glu Pro Gly Val 
                325                 330                 335     


Tyr Tyr Gln Gly Leu Tyr Ser Arg Ser Leu Leu Asn Ala Ser 
            340                 345                 350 


<210>  309
<211>  308
<212>  PRT
<213>  Homo sapiens

<400>  309

Met Val Val Gly Arg Gly Leu Leu Gly Arg Arg Ser Leu Ala Ala Leu 
1               5                   10                  15      


Gly Ala Ala Cys Ala Arg Arg Gly Leu Gly Pro Ala Leu Leu Gly Val 
            20                  25                  30          


Phe Cys His Thr Asp Leu Arg Lys Asn Leu Thr Val Asp Glu Gly Thr 
        35                  40                  45              


Met Lys Val Glu Val Leu Pro Ala Leu Thr Asp Asn Tyr Met Tyr Leu 
    50                  55                  60                  


Val Ile Asp Asp Glu Thr Lys Glu Ala Ala Ile Val Asp Pro Val Gln 
65                  70                  75                  80  


Pro Gln Lys Val Val Asp Ala Ala Arg Lys His Gly Val Lys Leu Thr 
                85                  90                  95      


Thr Val Leu Thr Thr His His His Trp Asp His Ala Gly Gly Asn Glu 
            100                 105                 110         


Lys Leu Val Lys Leu Glu Ser Gly Leu Lys Val Tyr Gly Gly Asp Asp 
        115                 120                 125             


Arg Ile Gly Ala Leu Thr His Lys Ile Thr His Leu Ser Thr Leu Gln 
    130                 135                 140                 


Val Gly Ser Leu Asn Val Lys Cys Leu Ala Thr Pro Cys His Thr Ser 
145                 150                 155                 160 


Gly His Ile Cys Tyr Phe Val Ser Lys Pro Gly Gly Ser Glu Pro Pro 
                165                 170                 175     


Ala Val Phe Thr Gly Asp Thr Leu Phe Val Ala Gly Cys Gly Lys Phe 
            180                 185                 190         


Tyr Glu Gly Thr Ala Asp Glu Met Cys Lys Ala Leu Leu Glu Val Leu 
        195                 200                 205             


Gly Arg Leu Pro Pro Asp Thr Arg Val Tyr Cys Gly His Glu Tyr Thr 
    210                 215                 220                 


Ile Asn Asn Leu Lys Phe Ala Arg His Val Glu Pro Gly Asn Ala Ala 
225                 230                 235                 240 


Ile Arg Glu Lys Leu Ala Trp Ala Lys Glu Lys Tyr Ser Ile Gly Glu 
                245                 250                 255     


Pro Thr Val Pro Ser Thr Leu Ala Glu Glu Phe Thr Tyr Asn Pro Phe 
            260                 265                 270         


Met Arg Val Arg Glu Lys Thr Val Gln Gln His Ala Gly Glu Thr Asp 
        275                 280                 285             


Pro Val Thr Thr Met Arg Ala Val Arg Arg Glu Lys Asp Gln Phe Lys 
    290                 295                 300                 


Met Pro Arg Asp 
305             


<210>  310
<211>  242
<212>  PRT
<213>  Homo sapiens

<400>  310

Met Pro Gly Pro Trp Leu Leu Leu Ala Leu Ala Leu Thr Leu Asn Leu 
1               5                   10                  15      


Thr Gly Val Pro Gly Gly Arg Ala Gln Pro Glu Ala Ala Gln Gln Glu 
            20                  25                  30          


Ala Val Thr Ala Ala Glu His Pro Gly Leu Asp Asp Phe Leu Arg Gln 
        35                  40                  45              


Val Glu Arg Leu Leu Phe Leu Arg Glu Asn Ile Gln Arg Leu Gln Gly 
    50                  55                  60                  


Asp Gln Gly Glu His Ser Ala Ser Gln Ile Phe Gln Ser Asp Trp Leu 
65                  70                  75                  80  


Ser Lys Arg Gln His Pro Gly Lys Arg Glu Glu Glu Glu Glu Glu Gly 
                85                  90                  95      


Val Glu Glu Glu Glu Glu Glu Glu Gly Gly Ala Val Gly Pro His Lys 
            100                 105                 110         


Arg Gln His Pro Gly Arg Arg Glu Asp Glu Ala Ser Trp Ser Val Asp 
        115                 120                 125             


Val Thr Gln His Lys Arg Gln His Pro Gly Arg Arg Ser Pro Trp Leu 
    130                 135                 140                 


Ala Tyr Ala Val Pro Lys Arg Gln His Pro Gly Arg Arg Leu Ala Asp 
145                 150                 155                 160 


Pro Lys Ala Gln Arg Ser Trp Glu Glu Glu Glu Glu Glu Glu Glu Arg 
                165                 170                 175     


Glu Glu Asp Leu Met Pro Glu Lys Arg Gln His Pro Gly Lys Arg Ala 
            180                 185                 190         


Leu Gly Gly Pro Cys Gly Pro Gln Gly Ala Tyr Gly Gln Ala Gly Leu 
        195                 200                 205             


Leu Leu Gly Leu Leu Asp Asp Leu Ser Arg Ser Gln Gly Ala Glu Glu 
    210                 215                 220                 


Lys Arg Gln His Pro Gly Arg Arg Ala Ala Trp Val Arg Glu Pro Leu 
225                 230                 235                 240 


Glu Glu 
        


<210>  311
<211>  400
<212>  PRT
<213>  Homo sapiens

<400>  311

Met Thr Thr Lys Asn Leu Glu Thr Lys Val Thr Val Thr Ser Ser Pro 
1               5                   10                  15      


Ile Arg Gly Ala Gly Asp Gly Met Glu Thr Glu Glu Pro Pro Lys Ser 
            20                  25                  30          


Val Glu Val Thr Ser Gly Val Gln Ser Arg Lys His His Ser Leu Gln 
        35                  40                  45              


Ser Pro Trp Lys Lys Ala Val Pro Ser Glu Ser Pro Gly Val Leu Gln 
    50                  55                  60                  


Leu Gly Lys Met Leu Thr Glu Lys Ala Met Glu Val Lys Ala Val Arg 
65                  70                  75                  80  


Ile Leu Val Pro Lys Ala Ala Ile Thr His Asp Ile Pro Asn Lys Asn 
                85                  90                  95      


Thr Lys Val Lys Ser Leu Gly His His Lys Gly Glu Phe Leu Gly Gln 
            100                 105                 110         


Ser Glu Gly Val Ile Glu Pro Asn Lys Glu Leu Ser Glu Val Lys Asn 
        115                 120                 125             


Val Leu Glu Lys Leu Lys Asn Ser Glu Arg Arg Leu Leu Gln Asp Lys 
    130                 135                 140                 


Glu Gly Leu Ser Asn Gln Leu Arg Val Gln Thr Glu Val Asn Arg Glu 
145                 150                 155                 160 


Leu Lys Lys Leu Leu Val Ala Ser Val Gly Asp Asp Leu Gln Tyr His 
                165                 170                 175     


Phe Glu Arg Leu Ala Arg Glu Lys Asn Gln Leu Ile Leu Glu Asn Glu 
            180                 185                 190         


Ala Leu Gly Arg Asn Thr Ala Gln Leu Ser Glu Gln Leu Glu Arg Met 
        195                 200                 205             


Ser Ile Gln Cys Asp Val Trp Arg Ser Lys Phe Leu Ala Ser Arg Val 
    210                 215                 220                 


Met Ala Asp Glu Leu Thr Asn Ser Arg Ala Ala Leu Gln Arg Gln Asn 
225                 230                 235                 240 


Arg Asp Ala His Gly Ala Ile Gln Asp Leu Leu Ser Glu Arg Glu Gln 
                245                 250                 255     


Phe Arg Gln Glu Met Ile Ala Thr Gln Lys Leu Leu Glu Glu Leu Leu 
            260                 265                 270         


Val Ser Leu Gln Trp Gly Arg Glu Gln Thr Tyr Ser Pro Ser Val Gln 
        275                 280                 285             


Pro His Ser Thr Ala Glu Leu Ala Leu Thr Asn His Lys Leu Ala Lys 
    290                 295                 300                 


Ala Val Asn Ser His Leu Leu Gly Asn Val Gly Ile Asn Asn Gln Lys 
305                 310                 315                 320 


Lys Ile Pro Ser Thr Val Glu Phe Cys Ser Thr Pro Ala Glu Lys Met 
                325                 330                 335     


Ala Glu Thr Val Leu Arg Ile Leu Asp Pro Val Thr Cys Lys Glu Ser 
            340                 345                 350         


Ser Pro Asp Asn Pro Phe Phe Glu Ser Ser Pro Thr Thr Leu Leu Ala 
        355                 360                 365             


Thr Lys Lys Asn Ile Gly Arg Phe His Pro Tyr Thr Arg Tyr Glu Asn 
    370                 375                 380                 


Ile Thr Phe Asn Cys Cys Asn His Cys Arg Gly Glu Leu Ile Ala Leu 
385                 390                 395                 400 


<210>  312
<211>  155
<212>  PRT
<213>  Homo sapiens

<400>  312

Met Glu Arg Ile Val Ile Cys Leu Met Val Ile Phe Leu Gly Thr Leu 
1               5                   10                  15      


Val His Lys Ser Ser Ser Gln Gly Gln Asp Arg His Met Ile Arg Met 
            20                  25                  30          


Arg Gln Leu Ile Asp Ile Val Asp Gln Leu Lys Asn Tyr Val Asn Asp 
        35                  40                  45              


Leu Val Pro Glu Phe Leu Pro Ala Pro Glu Asp Val Glu Thr Asn Cys 
    50                  55                  60                  


Glu Trp Ser Ala Phe Ser Cys Phe Gln Lys Ala Gln Leu Lys Ser Ala 
65                  70                  75                  80  


Asn Thr Gly Asn Asn Glu Arg Ile Ile Asn Val Ser Ile Lys Lys Leu 
                85                  90                  95      


Lys Arg Lys Pro Pro Ser Thr Asn Ala Gly Arg Arg Gln Lys His Arg 
            100                 105                 110         


Leu Thr Cys Pro Ser Cys Asp Ser Tyr Glu Lys Lys Pro Pro Lys Glu 
        115                 120                 125             


Phe Leu Glu Arg Phe Lys Ser Leu Leu Gln Lys Met Ile His Gln His 
    130                 135                 140                 


Leu Ser Ser Arg Thr His Gly Ser Glu Asp Ser 
145                 150                 155 


<210>  313
<211>  233
<212>  PRT
<213>  Homo sapiens

<400>  313

Met Glu Leu Pro Thr Lys Pro Gly Thr Phe Asp Leu Gly Leu Ala Thr 
1               5                   10                  15      


Trp Ser Pro Ser Phe Gln Gly Glu Thr His Arg Ala Gln Ala Arg Arg 
            20                  25                  30          


Arg Asp Val Gly Arg Gln Leu Pro Glu Tyr Lys Ala Val Val Val Gly 
        35                  40                  45              


Ala Ser Gly Val Gly Lys Ser Ala Leu Thr Ile Gln Leu Asn His Gln 
    50                  55                  60                  


Cys Phe Val Glu Asp His Asp Pro Thr Ile Gln Asp Ser Tyr Trp Lys 
65                  70                  75                  80  


Glu Leu Thr Leu Asp Ser Gly Asp Cys Ile Leu Asn Val Leu Asp Thr 
                85                  90                  95      


Ala Gly Gln Ala Ile His Arg Ala Leu Arg Asp Gln Cys Leu Ala Val 
            100                 105                 110         


Cys Asp Gly Val Leu Gly Val Phe Ala Leu Asp Asp Pro Ser Ser Leu 
        115                 120                 125             


Ile Gln Leu Gln Gln Ile Trp Ala Thr Trp Gly Pro His Pro Ala Gln 
    130                 135                 140                 


Pro Leu Val Leu Val Gly Asn Lys Cys Asp Leu Val Thr Thr Ala Gly 
145                 150                 155                 160 


Asp Ala His Ala Ala Ala Ala Ala Leu Ala His Ser Trp Gly Ala His 
                165                 170                 175     


Phe Val Glu Thr Ser Ala Lys Thr Arg Gln Gly Val Glu Glu Ala Phe 
            180                 185                 190         


Ser Leu Leu Val His Glu Ile Gln Arg Val Gln Glu Ala Met Ala Lys 
        195                 200                 205             


Glu Pro Met Ala Arg Ser Cys Arg Glu Lys Thr Arg His Gln Lys Ala 
    210                 215                 220                 


Thr Cys His Cys Gly Cys Ser Val Ala 
225                 230             


<210>  314
<211>  596
<212>  PRT
<213>  Homo sapiens

<400>  314

Met Ala Thr Glu Asn Gly Ala Val Glu Leu Gly Ile Gln Asn Pro Ser 
1               5                   10                  15      


Thr Asp Lys Ala Pro Lys Gly Pro Thr Gly Glu Arg Pro Leu Ala Ala 
            20                  25                  30          


Gly Lys Asp Pro Gly Pro Pro Asp Pro Lys Lys Ala Pro Asp Pro Pro 
        35                  40                  45              


Thr Leu Lys Lys Asp Ala Lys Ala Pro Ala Ser Glu Lys Gly Asp Gly 
    50                  55                  60                  


Thr Leu Ala Gln Pro Ser Thr Ser Ser Gln Gly Pro Lys Gly Glu Gly 
65                  70                  75                  80  


Asp Arg Gly Gly Gly Pro Ala Glu Gly Ser Ala Gly Pro Pro Ala Ala 
                85                  90                  95      


Leu Pro Gln Gln Thr Ala Thr Pro Glu Thr Ser Val Lys Lys Pro Lys 
            100                 105                 110         


Ala Glu Gln Gly Ala Ser Gly Ser Gln Asp Pro Gly Lys Pro Arg Val 
        115                 120                 125             


Gly Lys Lys Ala Ala Glu Gly Gln Ala Ala Ala Arg Arg Gly Ser Pro 
    130                 135                 140                 


Ala Phe Leu His Ser Pro Ser Cys Pro Ala Ile Ile Ser Ser Ser Glu 
145                 150                 155                 160 


Lys Leu Leu Ala Lys Lys Pro Pro Ser Glu Ala Ser Glu Leu Thr Phe 
                165                 170                 175     


Glu Gly Val Pro Met Thr His Ser Pro Thr Asp Pro Arg Pro Ala Lys 
            180                 185                 190         


Ala Glu Glu Gly Lys Asn Ile Leu Ala Glu Ser Gln Lys Glu Val Gly 
        195                 200                 205             


Glu Lys Thr Pro Gly Gln Ala Gly Gln Ala Lys Met Gln Gly Asp Thr 
    210                 215                 220                 


Ser Arg Gly Ile Glu Phe Gln Ala Val Pro Ser Glu Lys Ser Glu Val 
225                 230                 235                 240 


Gly Gln Ala Leu Cys Leu Thr Ala Arg Glu Glu Asp Cys Phe Gln Ile 
                245                 250                 255     


Leu Asp Asp Cys Pro Pro Pro Pro Ala Pro Phe Pro His Arg Met Val 
            260                 265                 270         


Glu Leu Arg Thr Gly Asn Val Ser Ser Glu Phe Ser Met Asn Ser Lys 
        275                 280                 285             


Glu Ala Leu Gly Gly Gly Lys Phe Gly Ala Val Cys Thr Cys Met Glu 
    290                 295                 300                 


Lys Ala Thr Gly Leu Lys Leu Ala Ala Lys Val Ile Lys Lys Gln Thr 
305                 310                 315                 320 


Pro Lys Asp Lys Glu Met Val Leu Leu Glu Ile Glu Val Met Asn Gln 
                325                 330                 335     


Leu Asn His Arg Asn Leu Ile Gln Leu Tyr Ala Ala Ile Glu Thr Pro 
            340                 345                 350         


His Glu Ile Val Leu Phe Met Glu Tyr Ile Glu Gly Gly Glu Leu Phe 
        355                 360                 365             


Glu Arg Ile Val Asp Glu Asp Tyr His Leu Thr Glu Val Asp Thr Met 
    370                 375                 380                 


Val Phe Val Arg Gln Ile Cys Asp Gly Ile Leu Phe Met His Lys Met 
385                 390                 395                 400 


Arg Val Leu His Leu Asp Leu Lys Pro Glu Asn Ile Leu Cys Val Asn 
                405                 410                 415     


Thr Thr Gly His Leu Val Lys Ile Ile Asp Phe Gly Leu Ala Arg Arg 
            420                 425                 430         


Tyr Asn Pro Asn Glu Lys Leu Lys Val Asn Phe Gly Thr Pro Glu Phe 
        435                 440                 445             


Leu Ser Pro Glu Val Val Asn Tyr Asp Gln Ile Ser Asp Lys Thr Asp 
    450                 455                 460                 


Met Trp Ser Met Gly Val Ile Thr Tyr Met Leu Leu Ser Gly Leu Ser 
465                 470                 475                 480 


Pro Phe Leu Gly Asp Asp Asp Thr Glu Thr Leu Asn Asn Val Leu Ser 
                485                 490                 495     


Gly Asn Trp Tyr Phe Asp Glu Glu Thr Phe Glu Ala Val Ser Asp Glu 
            500                 505                 510         


Ala Lys Asp Phe Val Ser Asn Leu Ile Val Lys Asp Gln Arg Ala Arg 
        515                 520                 525             


Met Asn Ala Ala Gln Cys Leu Ala His Pro Trp Leu Asn Asn Leu Ala 
    530                 535                 540                 


Glu Lys Ala Lys Arg Cys Asn Arg Arg Leu Lys Ser Gln Ile Leu Leu 
545                 550                 555                 560 


Lys Lys Tyr Leu Met Lys Arg Arg Trp Lys Lys Asn Phe Ile Ala Val 
                565                 570                 575     


Ser Ala Ala Asn Arg Phe Lys Lys Ile Ser Ser Ser Gly Ala Leu Met 
            580                 585                 590         


Ala Leu Gly Val 
        595     


<210>  315
<211>  466
<212>  PRT
<213>  Homo sapiens

<400>  315

Met Ala Asp Gln Leu Tyr Leu Glu Asn Ile Asp Glu Phe Val Thr Asp 
1               5                   10                  15      


Gln Asn Lys Ile Val Thr Tyr Lys Trp Leu Ser Tyr Thr Leu Gly Val 
            20                  25                  30          


His Val Asn Gln Ala Lys Gln Met Leu Tyr Asp Tyr Val Glu Arg Lys 
        35                  40                  45              


Arg Lys Glu Asn Ser Gly Ala Gln Leu His Val Thr Tyr Leu Val Ser 
    50                  55                  60                  


Gly Ser Leu Ile Gln Asn Gly His Ser Cys His Lys Val Ala Val Val 
65                  70                  75                  80  


Arg Glu Asp Lys Leu Glu Ala Val Lys Ser Lys Leu Ala Val Thr Ala 
                85                  90                  95      


Ser Ile His Val Tyr Ser Ile Gln Lys Ala Met Leu Lys Asp Ser Gly 
            100                 105                 110         


Pro Leu Phe Asn Thr Asp Tyr Asp Ile Leu Lys Ser Asn Leu Gln Asn 
        115                 120                 125             


Cys Ser Lys Phe Ser Ala Ile Gln Cys Ala Ala Ala Val Pro Arg Ala 
    130                 135                 140                 


Pro Ala Glu Ser Ser Ser Ser Ser Lys Lys Phe Glu Gln Ser His Leu 
145                 150                 155                 160 


His Met Ser Ser Glu Thr Gln Ala Asn Asn Glu Leu Thr Thr Asn Gly 
                165                 170                 175     


His Gly Pro Pro Ala Ser Lys Gln Val Ser Gln Gln Pro Lys Gly Ile 
            180                 185                 190         


Met Gly Met Phe Ala Ser Lys Ala Ala Ala Lys Thr Gln Glu Thr Asn 
        195                 200                 205             


Lys Glu Thr Lys Thr Glu Ala Lys Glu Val Thr Asn Ala Ser Ala Ala 
    210                 215                 220                 


Gly Asn Lys Ala Pro Gly Lys Gly Asn Met Met Ser Asn Phe Phe Gly 
225                 230                 235                 240 


Lys Ala Ala Met Asn Lys Phe Lys Val Asn Leu Asp Ser Glu Gln Ala 
                245                 250                 255     


Val Lys Glu Glu Lys Ile Val Glu Gln Pro Thr Val Ser Val Thr Glu 
            260                 265                 270         


Pro Lys Leu Ala Thr Pro Ala Gly Leu Lys Lys Ser Ser Lys Lys Ala 
        275                 280                 285             


Glu Pro Val Lys Val Leu Gln Lys Glu Lys Lys Arg Gly Lys Arg Val 
    290                 295                 300                 


Ala Leu Ser Asp Asp Glu Thr Lys Glu Thr Glu Asn Met Arg Lys Lys 
305                 310                 315                 320 


Arg Arg Arg Ile Lys Leu Pro Glu Ser Asp Ser Ser Glu Asp Glu Val 
                325                 330                 335     


Phe Pro Asp Ser Pro Gly Ala Tyr Glu Ala Glu Ser Pro Ser Pro Pro 
            340                 345                 350         


Pro Pro Pro Ser Pro Pro Leu Glu Pro Val Pro Lys Thr Glu Pro Glu 
        355                 360                 365             


Pro Pro Ser Val Lys Ser Ser Ser Gly Glu Asn Lys Arg Lys Arg Lys 
    370                 375                 380                 


Arg Val Leu Lys Ser Lys Thr Tyr Leu Asp Gly Glu Gly Cys Ile Val 
385                 390                 395                 400 


Thr Glu Lys Val Tyr Glu Ser Glu Ser Cys Thr Asp Ser Glu Glu Glu 
                405                 410                 415     


Leu Asn Met Lys Thr Ser Ser Val His Arg Pro Pro Ala Met Thr Val 
            420                 425                 430         


Lys Lys Glu Pro Arg Glu Glu Arg Lys Gly Pro Lys Lys Gly Thr Ala 
        435                 440                 445             


Ala Leu Gly Lys Ala Asn Arg Gln Val Ser Ile Thr Gly Phe Phe Gln 
    450                 455                 460                 


Arg Lys 
465     


<210>  316
<211>  345
<212>  PRT
<213>  Homo sapiens

<400>  316

Met Glu Glu Met Ser Leu Ser Gly Leu Asp Asn Ser Lys Leu Glu Ala 
1               5                   10                  15      


Ile Ala Gln Glu Ile Tyr Ala Asp Leu Val Glu Asp Ser Cys Leu Gly 
            20                  25                  30          


Phe Cys Phe Glu Val His Arg Ala Val Lys Cys Gly Tyr Phe Phe Leu 
        35                  40                  45              


Asp Asp Thr Asp Pro Asp Ser Met Lys Asp Phe Glu Ile Val Asp Gln 
    50                  55                  60                  


Pro Gly Leu Asp Ile Phe Gly Gln Val Phe Asn Gln Trp Lys Ser Lys 
65                  70                  75                  80  


Glu Cys Val Cys Pro Asn Cys Ser Arg Ser Ile Ala Ala Ser Arg Phe 
                85                  90                  95      


Ala Pro His Leu Glu Lys Cys Leu Gly Met Gly Arg Asn Ser Ser Arg 
            100                 105                 110         


Ile Ala Asn Arg Arg Ile Ala Asn Ser Asn Asn Met Asn Lys Ser Glu 
        115                 120                 125             


Ser Asp Gln Glu Asp Asn Asp Asp Ile Asn Asp Asn Asp Trp Ser Tyr 
    130                 135                 140                 


Gly Ser Glu Lys Lys Ala Lys Lys Arg Lys Ser Asp Lys Asn Pro Asn 
145                 150                 155                 160 


Ser Pro Arg Arg Ser Lys Ser Leu Lys His Lys Asn Gly Glu Leu Ser 
                165                 170                 175     


Asn Ser Asp Pro Phe Lys Tyr Asn Asn Ser Thr Gly Ile Ser Tyr Glu 
            180                 185                 190         


Thr Leu Gly Pro Glu Glu Leu Arg Ser Leu Leu Thr Thr Gln Cys Gly 
        195                 200                 205             


Val Ile Ser Glu His Thr Lys Lys Met Cys Thr Arg Ser Leu Arg Cys 
    210                 215                 220                 


Pro Gln His Thr Asp Glu Gln Arg Arg Thr Val Arg Ile Tyr Phe Leu 
225                 230                 235                 240 


Gly Pro Ser Ala Val Leu Pro Glu Val Glu Ser Ser Leu Asp Asn Asp 
                245                 250                 255     


Ser Phe Asp Met Thr Asp Ser Gln Ala Leu Ile Ser Arg Leu Gln Trp 
            260                 265                 270         


Asp Gly Ser Ser Asp Leu Ser Pro Ser Asp Ser Gly Ser Ser Lys Thr 
        275                 280                 285             


Ser Glu Asn Gln Gly Trp Gly Leu Gly Thr Asn Ser Ser Glu Ser Arg 
    290                 295                 300                 


Lys Thr Lys Lys Lys Lys Ser His Leu Ser Leu Val Gly Thr Ala Ser 
305                 310                 315                 320 


Gly Leu Gly Ser Asn Lys Lys Lys Lys Pro Lys Pro Pro Ala Pro Pro 
                325                 330                 335     


Thr Pro Ser Ile Tyr Asp Asp Ile Asn 
            340                 345 


<210>  317
<211>  227
<212>  PRT
<213>  Homo sapiens

<400>  317

Met Thr Asp Phe Lys Leu Gly Ile Val Arg Leu Gly Arg Val Ala Gly 
1               5                   10                  15      


Lys Thr Lys Tyr Thr Leu Ile Asp Glu Gln Asp Ile Pro Leu Val Glu 
            20                  25                  30          


Ser Tyr Ser Phe Glu Ala Arg Met Glu Val Asp Ala Asp Gly Asn Gly 
        35                  40                  45              


Ala Lys Ile Phe Ala Tyr Ala Phe Asp Lys Asn Arg Gly Arg Gly Ser 
    50                  55                  60                  


Gly Arg Leu Leu His Glu Leu Leu Trp Glu Arg His Arg Gly Gly Val 
65                  70                  75                  80  


Ala Pro Gly Phe Gln Val Val His Leu Asn Ala Val Thr Val Asp Asn 
                85                  90                  95      


Arg Leu Asp Asn Leu Gln Leu Val Pro Trp Gly Trp Arg Pro Lys Ala 
            100                 105                 110         


Glu Glu Thr Ser Ser Lys Gln Arg Glu Gln Ser Leu Tyr Trp Leu Ala 
        115                 120                 125             


Ile Gln Gln Leu Pro Thr Asp Pro Ile Glu Glu Gln Phe Pro Val Leu 
    130                 135                 140                 


Asn Val Thr Arg Tyr Tyr Asn Ala Asn Gly Asp Val Val Glu Glu Glu 
145                 150                 155                 160 


Glu Asn Ser Cys Thr Tyr Tyr Glu Cys His Tyr Pro Pro Cys Thr Val 
                165                 170                 175     


Ile Glu Lys Gln Leu Arg Glu Phe Asn Ile Cys Gly Arg Cys Gln Val 
            180                 185                 190         


Ala Arg Tyr Cys Gly Ser Gln Cys Gln Gln Lys Asp Trp Pro Ala His 
        195                 200                 205             


Lys Lys His Cys Arg Glu Arg Lys Arg Pro Phe Gln His Glu Leu Glu 
    210                 215                 220                 


Pro Glu Arg 
225         


<210>  318
<211>  140
<212>  PRT
<213>  Homo sapiens

<400>  318

Met Phe Phe Thr Ile Ser Arg Lys Asn Met Ser Gln Lys Leu Ser Leu 
1               5                   10                  15      


Leu Leu Leu Val Phe Gly Leu Ile Trp Gly Leu Met Leu Leu His Tyr 
            20                  25                  30          


Thr Phe Gln Gln Pro Arg His Gln Ser Ser Val Lys Leu Arg Glu Gln 
        35                  40                  45              


Ile Leu Asp Leu Ser Lys Arg Tyr Val Lys Ala Leu Ala Glu Glu Asn 
    50                  55                  60                  


Lys Asn Thr Val Asp Val Glu Asn Gly Ala Ser Met Ala Gly Tyr Ala 
65                  70                  75                  80  


Asp Leu Lys Arg Thr Ile Ala Val Leu Leu Asp Asp Ile Leu Gln Arg 
                85                  90                  95      


Leu Val Lys Leu Glu Asn Lys Val Asp Tyr Ile Val Val Asn Gly Ser 
            100                 105                 110         


Ala Ala Asn Thr Thr Asn Gly Thr Ser Gly Asn Leu Val Pro Val Thr 
        115                 120                 125             


Thr Asn Lys Arg Thr Asn Val Ser Gly Ser Ile Arg 
    130                 135                 140 


<210>  319
<211>  775
<212>  PRT
<213>  Homo sapiens

<400>  319

Met Ala Ala Leu Asp Ser Leu Ser Leu Phe Thr Ser Leu Gly Leu Ser 
1               5                   10                  15      


Glu Gln Lys Ala Arg Glu Thr Leu Lys Asn Ser Ala Leu Ser Ala Gln 
            20                  25                  30          


Leu Arg Glu Ala Ala Thr Gln Ala Gln Gln Thr Leu Gly Ser Thr Ile 
        35                  40                  45              


Asp Lys Ala Thr Gly Ile Leu Leu Tyr Gly Leu Ala Ser Arg Leu Arg 
    50                  55                  60                  


Asp Thr Arg Arg Leu Ser Phe Leu Val Ser Tyr Ile Ala Ser Lys Lys 
65                  70                  75                  80  


Ile His Thr Glu Pro Gln Leu Ser Ala Ala Leu Glu Tyr Val Arg Ser 
                85                  90                  95      


His Pro Leu Asp Pro Ile Asp Thr Val Asp Phe Glu Arg Glu Cys Gly 
            100                 105                 110         


Val Gly Val Ile Val Thr Pro Glu Gln Ile Glu Glu Ala Val Glu Ala 
        115                 120                 125             


Ala Ile Asn Arg His Arg Pro Gln Leu Leu Val Glu Arg Tyr His Phe 
    130                 135                 140                 


Asn Met Gly Leu Leu Met Gly Glu Ala Arg Ala Val Leu Lys Trp Ala 
145                 150                 155                 160 


Asp Gly Lys Met Ile Lys Asn Glu Val Asp Met Gln Val Leu His Leu 
                165                 170                 175     


Leu Gly Pro Lys Leu Glu Ala Asp Leu Glu Lys Lys Phe Lys Val Ala 
            180                 185                 190         


Lys Ala Arg Leu Glu Glu Thr Asp Arg Arg Thr Ala Lys Asp Val Val 
        195                 200                 205             


Glu Asn Gly Glu Thr Ala Asp Gln Thr Leu Ser Leu Met Glu Gln Leu 
    210                 215                 220                 


Arg Gly Glu Ala Leu Lys Phe His Lys Pro Gly Glu Asn Tyr Lys Thr 
225                 230                 235                 240 


Pro Gly Tyr Val Val Thr Pro His Thr Met Asn Leu Leu Lys Gln His 
                245                 250                 255     


Leu Glu Ile Thr Gly Gly Gln Val Arg Thr Arg Phe Pro Pro Glu Pro 
            260                 265                 270         


Asn Gly Ile Leu His Ile Gly His Ala Lys Ala Ile Asn Phe Asn Phe 
        275                 280                 285             


Gly Tyr Ala Lys Ala Asn Asn Gly Ile Cys Phe Leu Arg Phe Asp Asp 
    290                 295                 300                 


Thr Asn Pro Glu Lys Glu Glu Ala Lys Phe Phe Thr Ala Ile Cys Asp 
305                 310                 315                 320 


Met Val Ala Trp Leu Gly Tyr Thr Pro Tyr Lys Val Thr Tyr Ala Ser 
                325                 330                 335     


Asp Tyr Phe Asp Gln Leu Tyr Ala Trp Ala Val Glu Leu Ile Arg Arg 
            340                 345                 350         


Gly Leu Ala Tyr Val Cys His Gln Arg Gly Glu Glu Leu Lys Gly His 
        355                 360                 365             


Asn Thr Leu Pro Ser Pro Trp Arg Asp Arg Pro Met Glu Glu Ser Leu 
    370                 375                 380                 


Leu Leu Phe Glu Ala Met Arg Lys Gly Lys Phe Ser Glu Gly Glu Ala 
385                 390                 395                 400 


Thr Leu Arg Met Lys Leu Val Met Glu Asp Gly Lys Met Asp Pro Val 
                405                 410                 415     


Ala Tyr Arg Val Lys Tyr Thr Pro His His Arg Thr Gly Asp Lys Trp 
            420                 425                 430         


Cys Ile Tyr Pro Thr Tyr Asp Tyr Thr His Cys Leu Cys Asp Ser Ile 
        435                 440                 445             


Glu His Ile Thr His Ser Leu Cys Thr Lys Glu Phe Gln Ala Arg Arg 
    450                 455                 460                 


Ser Ser Tyr Phe Trp Leu Cys Asn Ala Leu Asp Val Tyr Cys Pro Val 
465                 470                 475                 480 


Gln Trp Glu Tyr Gly Arg Leu Asn Leu His Tyr Ala Val Val Ser Lys 
                485                 490                 495     


Arg Lys Ile Leu Gln Leu Val Ala Thr Gly Ala Val Arg Asp Trp Asp 
            500                 505                 510         


Asp Pro Arg Leu Phe Thr Leu Thr Ala Leu Arg Arg Arg Gly Phe Pro 
        515                 520                 525             


Pro Glu Ala Ile Asn Asn Phe Cys Ala Arg Val Gly Val Thr Val Ala 
    530                 535                 540                 


Gln Thr Thr Met Glu Pro His Leu Leu Glu Ala Cys Val Arg Asp Val 
545                 550                 555                 560 


Leu Asn Asp Thr Ala Pro Arg Ala Met Ala Val Leu Glu Ser Leu Arg 
                565                 570                 575     


Val Ile Ile Thr Asn Phe Pro Ala Ala Lys Ser Leu Asp Ile Gln Val 
            580                 585                 590         


Pro Asn Phe Pro Ala Asp Glu Thr Lys Gly Phe His Gln Val Pro Phe 
        595                 600                 605             


Ala Pro Ile Val Phe Ile Glu Arg Thr Asp Phe Lys Glu Glu Pro Glu 
    610                 615                 620                 


Pro Gly Phe Lys Arg Leu Ala Trp Gly Gln Pro Val Gly Leu Arg His 
625                 630                 635                 640 


Thr Gly Tyr Val Ile Glu Leu Gln His Val Val Lys Gly Pro Ser Gly 
                645                 650                 655     


Cys Val Glu Ser Leu Glu Val Thr Cys Arg Arg Ala Asp Ala Gly Glu 
            660                 665                 670         


Lys Pro Lys Ala Phe Ile His Trp Val Ser Gln Pro Leu Met Cys Glu 
        675                 680                 685             


Val Arg Leu Tyr Glu Arg Leu Phe Gln His Lys Asn Pro Glu Asp Pro 
    690                 695                 700                 


Thr Glu Val Pro Gly Gly Phe Leu Ser Asp Leu Asn Leu Ala Ser Leu 
705                 710                 715                 720 


His Val Val Asp Ala Ala Leu Val Asp Cys Ser Val Ala Leu Ala Lys 
                725                 730                 735     


Pro Phe Asp Lys Phe Gln Phe Glu Arg Leu Gly Tyr Phe Ser Val Asp 
            740                 745                 750         


Pro Asp Ser His Gln Gly Lys Leu Val Phe Asn Arg Thr Val Thr Leu 
        755                 760                 765             


Lys Glu Asp Pro Gly Lys Val 
    770                 775 


<210>  320
<211>  391
<212>  PRT
<213>  Homo sapiens

<400>  320

Met Glu Pro Leu Arg Val Leu Glu Leu Tyr Ser Gly Val Gly Gly Met 
1               5                   10                  15      


His His Ala Leu Arg Glu Ser Cys Ile Pro Ala Gln Val Val Ala Ala 
            20                  25                  30          


Ile Asp Val Asn Thr Val Ala Asn Glu Val Tyr Lys Tyr Asn Phe Pro 
        35                  40                  45              


His Thr Gln Leu Leu Ala Lys Thr Ile Glu Gly Ile Thr Leu Glu Glu 
    50                  55                  60                  


Phe Asp Arg Leu Ser Phe Asp Met Ile Leu Met Ser Pro Pro Cys Gln 
65                  70                  75                  80  


Pro Phe Thr Arg Ile Gly Arg Gln Gly Asp Met Thr Asp Ser Arg Thr 
                85                  90                  95      


Asn Ser Phe Leu His Ile Leu Asp Ile Leu Pro Arg Leu Gln Lys Leu 
            100                 105                 110         


Pro Lys Tyr Ile Leu Leu Glu Asn Val Lys Gly Phe Glu Val Ser Ser 
        115                 120                 125             


Thr Arg Asp Leu Leu Ile Gln Thr Ile Glu Asn Cys Gly Phe Gln Tyr 
    130                 135                 140                 


Gln Glu Phe Leu Leu Ser Pro Thr Ser Leu Gly Ile Pro Asn Ser Arg 
145                 150                 155                 160 


Leu Arg Tyr Phe Leu Ile Ala Lys Leu Gln Ser Glu Pro Leu Pro Phe 
                165                 170                 175     


Gln Ala Pro Gly Gln Val Leu Met Glu Phe Pro Lys Ile Glu Ser Val 
            180                 185                 190         


His Pro Gln Lys Tyr Ala Met Asp Val Glu Asn Lys Ile Gln Glu Lys 
        195                 200                 205             


Asn Val Glu Pro Asn Ile Ser Phe Asp Gly Ser Ile Gln Cys Ser Gly 
    210                 215                 220                 


Lys Asp Ala Ile Leu Phe Lys Leu Glu Thr Ala Glu Glu Ile His Arg 
225                 230                 235                 240 


Lys Asn Gln Gln Asp Ser Asp Leu Ser Val Lys Met Leu Lys Asp Phe 
                245                 250                 255     


Leu Glu Asp Asp Thr Asp Val Asn Gln Tyr Leu Leu Pro Pro Lys Ser 
            260                 265                 270         


Leu Leu Arg Tyr Ala Leu Leu Leu Asp Ile Val Gln Pro Thr Cys Arg 
        275                 280                 285             


Arg Ser Val Cys Phe Thr Lys Gly Tyr Gly Ser Tyr Ile Glu Gly Thr 
    290                 295                 300                 


Gly Ser Val Leu Gln Thr Ala Glu Asp Val Gln Val Glu Asn Ile Tyr 
305                 310                 315                 320 


Lys Ser Leu Thr Asn Leu Ser Gln Glu Glu Gln Ile Thr Lys Leu Leu 
                325                 330                 335     


Ile Leu Lys Leu Arg Tyr Phe Thr Pro Lys Glu Ile Ala Asn Leu Leu 
            340                 345                 350         


Gly Phe Pro Pro Glu Phe Gly Phe Pro Glu Lys Ile Thr Val Lys Gln 
        355                 360                 365             


Arg Tyr Arg Leu Leu Gly Asn Ser Leu Asn Val His Val Val Ala Lys 
    370                 375                 380                 


Leu Ile Lys Ile Leu Tyr Glu 
385                 390     


<210>  321
<211>  395
<212>  PRT
<213>  Homo sapiens

<400>  321

Met Asp Leu Gly Ile Pro Asp Leu Leu Asp Ala Trp Leu Glu Pro Pro 
1               5                   10                  15      


Glu Asp Ile Phe Ser Thr Gly Ser Val Leu Glu Leu Gly Leu His Cys 
            20                  25                  30          


Pro Pro Pro Glu Val Pro Val Thr Arg Leu Gln Glu Gln Gly Leu Gln 
        35                  40                  45              


Gly Trp Lys Ser Gly Gly Asp Arg Gly Cys Gly Leu Gln Glu Ser Glu 
    50                  55                  60                  


Pro Glu Asp Phe Leu Lys Leu Phe Ile Asp Pro Asn Glu Val Tyr Cys 
65                  70                  75                  80  


Ser Glu Ala Ser Pro Gly Ser Asp Ser Gly Ile Ser Glu Asp Pro Cys 
                85                  90                  95      


His Pro Asp Ser Pro Pro Ala Pro Arg Ala Thr Ser Ser Pro Met Leu 
            100                 105                 110         


Tyr Glu Val Val Tyr Glu Ala Gly Ala Leu Glu Arg Met Gln Gly Glu 
        115                 120                 125             


Thr Gly Pro Asn Val Gly Leu Ile Ser Ile Gln Leu Asp Gln Trp Ser 
    130                 135                 140                 


Pro Ala Phe Met Val Pro Asp Ser Cys Met Val Ser Glu Leu Pro Phe 
145                 150                 155                 160 


Asp Ala His Ala His Ile Leu Pro Arg Ala Gly Thr Val Ala Pro Val 
                165                 170                 175     


Pro Cys Thr Thr Leu Leu Pro Cys Gln Thr Leu Phe Leu Thr Asp Glu 
            180                 185                 190         


Glu Lys Arg Leu Leu Gly Gln Glu Gly Val Ser Leu Pro Ser His Leu 
        195                 200                 205             


Pro Leu Thr Lys Ala Glu Glu Arg Val Leu Lys Lys Val Arg Arg Lys 
    210                 215                 220                 


Ile Arg Asn Lys Gln Ser Ala Gln Asp Ser Arg Arg Arg Lys Lys Glu 
225                 230                 235                 240 


Tyr Ile Asp Gly Leu Glu Ser Arg Val Ala Ala Cys Ser Ala Gln Asn 
                245                 250                 255     


Gln Glu Leu Gln Lys Lys Val Gln Glu Leu Glu Arg His Asn Ile Ser 
            260                 265                 270         


Leu Val Ala Gln Leu Arg Gln Leu Gln Thr Leu Ile Ala Gln Thr Ser 
        275                 280                 285             


Asn Lys Ala Ala Gln Thr Ser Thr Cys Val Leu Ile Leu Leu Phe Ser 
    290                 295                 300                 


Leu Ala Leu Ile Ile Leu Pro Ser Phe Ser Pro Phe Gln Ser Arg Pro 
305                 310                 315                 320 


Glu Ala Gly Ser Glu Asp Tyr Gln Pro His Gly Val Thr Ser Arg Asn 
                325                 330                 335     


Ile Leu Thr His Lys Asp Val Thr Glu Asn Leu Glu Thr Gln Val Val 
            340                 345                 350         


Glu Ser Arg Leu Arg Glu Pro Pro Gly Ala Lys Asp Ala Asn Gly Ser 
        355                 360                 365             


Thr Arg Thr Leu Leu Glu Lys Met Gly Gly Lys Pro Arg Pro Ser Gly 
    370                 375                 380                 


Arg Ile Arg Ser Val Leu His Ala Asp Glu Met 
385                 390                 395 


<210>  322
<211>  236
<212>  PRT
<213>  Homo sapiens

<400>  322

Met Ala Ser Leu Asp Arg Val Lys Val Leu Val Leu Gly Asp Ser Gly 
1               5                   10                  15      


Val Gly Lys Ser Ser Leu Val His Leu Leu Cys Gln Asn Gln Val Leu 
            20                  25                  30          


Gly Asn Pro Ser Trp Thr Val Gly Cys Ser Val Asp Val Arg Val His 
        35                  40                  45              


Asp Tyr Lys Glu Gly Thr Pro Glu Glu Lys Thr Tyr Tyr Ile Glu Leu 
    50                  55                  60                  


Trp Asp Val Gly Gly Ser Val Gly Ser Ala Ser Ser Val Lys Ser Thr 
65                  70                  75                  80  


Arg Ala Val Phe Tyr Asn Ser Val Asn Gly Ile Ile Phe Val His Asp 
                85                  90                  95      


Leu Thr Asn Lys Lys Ser Ser Gln Asn Leu Arg Arg Trp Ser Leu Glu 
            100                 105                 110         


Ala Leu Asn Arg Asp Leu Val Pro Thr Gly Val Leu Val Thr Asn Gly 
        115                 120                 125             


Asp Tyr Asp Gln Glu Gln Phe Ala Asp Asn Gln Ile Pro Leu Leu Val 
    130                 135                 140                 


Ile Gly Thr Lys Leu Asp Gln Ile His Glu Thr Lys Arg His Glu Val 
145                 150                 155                 160 


Leu Thr Arg Thr Ala Phe Leu Ala Glu Asp Phe Asn Pro Glu Glu Ile 
                165                 170                 175     


Asn Leu Asp Cys Thr Asn Pro Arg Tyr Leu Ala Ala Gly Ser Ser Asn 
            180                 185                 190         


Ala Val Lys Leu Ser Arg Phe Phe Asp Lys Val Ile Glu Lys Arg Tyr 
        195                 200                 205             


Phe Leu Arg Glu Gly Asn Gln Ile Pro Gly Phe Pro Asp Arg Lys Arg 
    210                 215                 220                 


Phe Gly Ala Gly Thr Leu Lys Ser Leu His Tyr Asp 
225                 230                 235     


<210>  323
<211>  527
<212>  PRT
<213>  Homo sapiens

<400>  323

Met Ser Glu Asp Ser Ser Ala Leu Pro Trp Ser Ile Asn Arg Asp Asp 
1               5                   10                  15      


Tyr Glu Leu Gln Glu Val Ile Gly Ser Gly Ala Thr Ala Val Val Gln 
            20                  25                  30          


Ala Ala Tyr Cys Ala Pro Lys Lys Glu Lys Val Ala Ile Lys Arg Ile 
        35                  40                  45              


Asn Leu Glu Lys Cys Gln Thr Ser Met Asp Glu Leu Leu Lys Glu Ile 
    50                  55                  60                  


Gln Ala Met Ser Gln Cys His His Pro Asn Ile Val Ser Tyr Tyr Thr 
65                  70                  75                  80  


Ser Phe Val Val Lys Asp Glu Leu Trp Leu Val Met Lys Leu Leu Ser 
                85                  90                  95      


Gly Gly Ser Val Leu Asp Ile Ile Lys His Ile Val Ala Lys Gly Glu 
            100                 105                 110         


His Lys Ser Gly Val Leu Asp Glu Ser Thr Ile Ala Thr Ile Leu Arg 
        115                 120                 125             


Glu Val Leu Glu Gly Leu Glu Tyr Leu His Lys Asn Gly Gln Ile His 
    130                 135                 140                 


Arg Asp Val Lys Ala Gly Asn Ile Leu Leu Gly Glu Asp Gly Ser Val 
145                 150                 155                 160 


Gln Ile Ala Asp Phe Gly Val Ser Ala Phe Leu Ala Thr Gly Gly Asp 
                165                 170                 175     


Ile Thr Arg Asn Lys Val Arg Lys Thr Phe Val Gly Thr Pro Cys Trp 
            180                 185                 190         


Met Ala Pro Glu Val Met Glu Gln Val Arg Gly Tyr Asp Phe Lys Ala 
        195                 200                 205             


Asp Ile Trp Ser Phe Gly Ile Thr Ala Ile Glu Leu Ala Thr Gly Ala 
    210                 215                 220                 


Ala Pro Tyr His Lys Tyr Pro Pro Met Lys Val Leu Met Leu Thr Leu 
225                 230                 235                 240 


Gln Asn Asp Pro Pro Ser Leu Glu Thr Gly Val Gln Asp Lys Glu Met 
                245                 250                 255     


Leu Lys Lys Tyr Gly Lys Ser Phe Arg Lys Met Ile Ser Leu Cys Leu 
            260                 265                 270         


Gln Lys Asp Pro Glu Lys Arg Pro Thr Ala Ala Glu Leu Leu Arg His 
        275                 280                 285             


Lys Phe Phe Gln Lys Ala Lys Asn Lys Glu Phe Leu Gln Glu Lys Thr 
    290                 295                 300                 


Leu Gln Arg Ala Pro Thr Ile Ser Glu Arg Ala Lys Lys Val Arg Arg 
305                 310                 315                 320 


Val Pro Gly Ser Ser Gly Arg Leu His Lys Thr Glu Asp Gly Gly Trp 
                325                 330                 335     


Glu Trp Ser Asp Asp Glu Phe Asp Glu Glu Ser Glu Glu Gly Lys Ala 
            340                 345                 350         


Ala Ile Ser Gln Leu Arg Ser Pro Arg Val Lys Glu Ser Ile Ser Asn 
        355                 360                 365             


Ser Glu Leu Phe Pro Thr Thr Asp Pro Val Gly Thr Leu Leu Gln Val 
    370                 375                 380                 


Pro Glu Gln Ile Ser Ala His Leu Pro Gln Pro Ala Gly Gln Ile Ala 
385                 390                 395                 400 


Thr Gln Pro Thr Gln Val Ser Leu Pro Pro Thr Ala Glu Pro Ala Lys 
                405                 410                 415     


Thr Ala Gln Ala Leu Ser Ser Gly Ser Gly Ser Gln Glu Thr Lys Ile 
            420                 425                 430         


Pro Ile Ser Leu Val Leu Arg Leu Arg Asn Ser Lys Lys Glu Leu Asn 
        435                 440                 445             


Asp Ile Arg Phe Glu Phe Thr Pro Gly Arg Asp Thr Ala Glu Gly Val 
    450                 455                 460                 


Ser Gln Glu Leu Ile Ser Ala Gly Leu Val Asp Gly Arg Asp Leu Val 
465                 470                 475                 480 


Ile Val Ala Ala Asn Leu Gln Lys Ile Val Glu Glu Pro Gln Ser Asn 
                485                 490                 495     


Arg Ser Val Thr Phe Lys Leu Ala Ser Gly Val Glu Gly Ser Asp Ile 
            500                 505                 510         


Pro Asp Asp Gly Lys Leu Ile Gly Phe Ala Gln Leu Ser Ile Ser 
        515                 520                 525         


<210>  324
<211>  395
<212>  PRT
<213>  Homo sapiens

<400>  324

Met Ala Glu Asp Gly Leu Pro Lys Ile Tyr Ser His Pro Pro Thr Glu 
1               5                   10                  15      


Ser Ser Lys Thr Pro Thr Ala Ala Thr Ile Phe Phe Gly Ala Asp Asn 
            20                  25                  30          


Ala Ile Pro Lys Ser Glu Thr Thr Ile Thr Ser Glu Gly Asp His Val 
        35                  40                  45              


Thr Ser Val Asn Glu Tyr Met Leu Glu Ser Asp Phe Ser Thr Thr Thr 
    50                  55                  60                  


Asp Asn Lys Leu Thr Ala Lys Lys Glu Lys Leu Lys Ser Glu Asp Asp 
65                  70                  75                  80  


Met Gly Thr Asp Phe Ile Lys Ser Thr Thr His Leu Gln Lys Glu Ile 
                85                  90                  95      


Thr Ser Leu Thr Gly Thr Thr Asn Ser Ile Thr Arg Asp Ser Ile Thr 
            100                 105                 110         


Glu His Phe Met Pro Val Lys Ile Gly Asn Ile Ser Ser Pro Val Thr 
        115                 120                 125             


Thr Val Ser Leu Ile Asp Phe Ser Thr Asp Ile Ala Lys Glu Asp Ile 
    130                 135                 140                 


Leu Leu Ala Thr Ile Asp Thr Gly Asp Ala Glu Ile Ser Ile Thr Ser 
145                 150                 155                 160 


Glu Val Ser Gly Thr Leu Lys Asp Ser Ser Ala Gly Val Ala Asp Ala 
                165                 170                 175     


Pro Ala Phe Pro Arg Lys Lys Asp Glu Ala Asp Met Ser Asn Tyr Asn 
            180                 185                 190         


Ser Ser Ile Lys Ser Asn Val Pro Ala Asp Glu Ala Val Gln Val Thr 
        195                 200                 205             


Asp Ser Ile Ile Pro Glu Ala Glu Ile Pro Pro Ala Pro Glu Glu Ser 
    210                 215                 220                 


Phe Thr Thr Ile Pro Asp Ile Thr Ala Leu Glu Glu Glu Lys Ile Thr 
225                 230                 235                 240 


Glu Ile Asp Leu Ser Val Leu Glu Asp Asp Thr Ser Ala Val Ala Thr 
                245                 250                 255     


Leu Thr Asp Ser Asp Glu Lys Phe Ile Thr Val Phe Glu Leu Thr Thr 
            260                 265                 270         


Ser Ala Glu Lys Asp Lys Asp Lys Arg Glu Asp Thr Leu Leu Thr Asp 
        275                 280                 285             


Glu Glu Thr Thr Glu Gly Ala Ser Ile Trp Met Glu Arg Asp Thr Ala 
    290                 295                 300                 


Asn Glu Ala Glu Thr His Ser Val Leu Leu Thr Ala Val Glu Ser Arg 
305                 310                 315                 320 


Tyr Asp Phe Val Val Pro Ala Ser Ile Ala Thr Asn Leu Val Glu Glu 
                325                 330                 335     


Ser Ser Thr Glu Glu Asp Leu Ser Glu Thr Asp Asn Thr Glu Thr Val 
            340                 345                 350         


Pro Lys Ile Thr Glu Pro Phe Ser Gly Thr Thr Ser Val Leu Asp Thr 
        355                 360                 365             


Pro Asp Tyr Lys Glu Asp Thr Ser Thr Thr Glu Thr Asp Ile Phe Glu 
    370                 375                 380                 


Leu Leu Lys Glu Glu Pro Asp Glu Phe Met Ile 
385                 390                 395 


<210>  325
<211>  485
<212>  PRT
<213>  Homo sapiens

<400>  325

Met Arg Asp Asn Arg Ala Val Ser Leu Cys Gln Gln Glu Trp Met Cys 
1               5                   10                  15      


Pro Gly Pro Ala Gln Arg Ala Leu Tyr Arg Gly Ala Thr Gln Arg Lys 
            20                  25                  30          


Asp Ser His Val Ser Leu Ala Thr Gly Val Pro Trp Gly Tyr Glu Glu 
        35                  40                  45              


Thr Lys Thr Leu Leu Ala Ile Leu Ser Ser Ser Gln Phe Tyr Gly Lys 
    50                  55                  60                  


Leu Gln Thr Cys Gln Gln Asn Ser Gln Ile Tyr Arg Ala Met Ala Glu 
65                  70                  75                  80  


Gly Leu Trp Glu Gln Gly Phe Leu Arg Thr Pro Glu Gln Cys Arg Thr 
                85                  90                  95      


Lys Phe Lys Ser Leu Gln Leu Ser Tyr Arg Lys Val Arg Arg Gly Arg 
            100                 105                 110         


Val Pro Glu Pro Cys Ile Phe Tyr Glu Glu Met Asn Ala Leu Ser Gly 
        115                 120                 125             


Ser Trp Ala Ser Ala Pro Pro Met Ala Ser Asp Ala Val Pro Gly Gln 
    130                 135                 140                 


Glu Gly Ser Asp Ile Glu Ala Gly Glu Leu Asn His Gln Asn Gly Glu 
145                 150                 155                 160 


Pro Thr Glu Val Glu Asp Gly Thr Val Asp Gly Ala Asp Arg Asp Glu 
                165                 170                 175     


Lys Asp Phe Arg Asn Pro Gly Gln Glu Val Arg Lys Leu Asp Leu Pro 
            180                 185                 190         


Val Leu Phe Pro Asn Arg Leu Gly Phe Glu Phe Lys Asn Glu Ile Lys 
        195                 200                 205             


Lys Glu Asn Leu Lys Trp Asp Asp Ser Glu Glu Val Glu Ile Asn Lys 
    210                 215                 220                 


Ala Leu Gln Arg Lys Ser Arg Gly Val Tyr Trp His Ser Glu Leu Gln 
225                 230                 235                 240 


Lys Gly Leu Glu Ser Glu Pro Thr Ser Arg Arg Gln Cys Arg Asn Ser 
                245                 250                 255     


Pro Gly Glu Ser Glu Glu Lys Thr Pro Ser Gln Glu Lys Met Ser His 
            260                 265                 270         


Gln Ser Phe Cys Ala Arg Asp Lys Ala Cys Thr His Ile Leu Cys Gly 
        275                 280                 285             


Lys Asn Cys Ser Gln Ser Val His Ser Pro His Lys Pro Ala Leu Lys 
    290                 295                 300                 


Leu Glu Lys Val Ser Gln Cys Pro Glu Cys Gly Lys Thr Phe Ser Arg 
305                 310                 315                 320 


Ser Ser Tyr Leu Val Arg His Gln Arg Ile His Thr Gly Glu Lys Pro 
                325                 330                 335     


His Lys Cys Ser Glu Cys Gly Lys Gly Phe Ser Glu Arg Ser Asn Leu 
            340                 345                 350         


Thr Ala His Leu Arg Thr His Thr Gly Glu Arg Pro Tyr Gln Cys Gly 
        355                 360                 365             


Gln Cys Gly Lys Ser Phe Asn Gln Ser Ser Ser Leu Ile Val His Gln 
    370                 375                 380                 


Arg Thr His Thr Gly Glu Lys Pro Tyr Gln Cys Ile Val Cys Gly Lys 
385                 390                 395                 400 


Arg Phe Asn Asn Ser Ser Gln Phe Ser Ala His Arg Arg Ile His Thr 
                405                 410                 415     


Gly Glu Ser Pro Tyr Lys Cys Ala Val Cys Gly Lys Ile Phe Asn Asn 
            420                 425                 430         


Ser Ser His Phe Ser Ala His Arg Lys Thr His Thr Gly Glu Lys Pro 
        435                 440                 445             


Tyr Arg Cys Ser His Cys Glu Arg Gly Phe Thr Lys Asn Ser Ala Leu 
    450                 455                 460                 


Thr Arg His Gln Thr Val His Met Lys Ala Val Leu Ser Ser Gln Glu 
465                 470                 475                 480 


Gly Arg Asp Ala Leu 
                485 


<210>  326
<211>  1827
<212>  PRT
<213>  Homo sapiens

<400>  326

Met Ala Asp Glu Arg Lys Asp Glu Ala Lys Ala Pro His Trp Thr Ser 
1               5                   10                  15      


Ala Pro Leu Thr Glu Ala Ser Ala His Ser His Pro Pro Glu Ile Lys 
            20                  25                  30          


Asp Gln Gly Gly Ala Gly Glu Gly Leu Val Arg Ser Ala Asn Gly Phe 
        35                  40                  45              


Pro Tyr Arg Glu Asp Glu Glu Gly Ala Phe Gly Glu His Gly Ser Gln 
    50                  55                  60                  


Gly Thr Tyr Ser Asn Thr Lys Glu Asn Gly Ile Asn Gly Glu Leu Thr 
65                  70                  75                  80  


Ser Ala Asp Arg Glu Thr Ala Glu Glu Val Ser Ala Arg Ile Val Gln 
                85                  90                  95      


Val Val Thr Ala Glu Ala Val Ala Val Leu Lys Gly Glu Gln Glu Lys 
            100                 105                 110         


Glu Ala Gln His Lys Asp Gln Thr Ala Ala Leu Pro Leu Ala Ala Glu 
        115                 120                 125             


Glu Thr Ala Asn Leu Pro Pro Ser Pro Pro Pro Ser Pro Ala Ser Glu 
    130                 135                 140                 


Gln Thr Val Thr Val Glu Glu Asp Leu Leu Thr Ala Ser Lys Met Glu 
145                 150                 155                 160 


Phe His Asp Gln Gln Glu Leu Thr Pro Ser Thr Ala Glu Pro Ser Asp 
                165                 170                 175     


Gln Lys Glu Lys Glu Ser Glu Lys Gln Ser Lys Pro Gly Glu Asp Leu 
            180                 185                 190         


Lys His Ala Ala Leu Val Ser Gln Pro Glu Thr Thr Lys Thr Tyr Pro 
        195                 200                 205             


Asp Lys Lys Asp Met Gln Gly Thr Glu Glu Glu Lys Ala Pro Leu Ala 
    210                 215                 220                 


Leu Phe Gly His Thr Leu Val Ala Ser Leu Glu Asp Met Lys Gln Lys 
225                 230                 235                 240 


Thr Glu Pro Ser Leu Val Val Pro Gly Ile Asp Leu Pro Lys Glu Pro 
                245                 250                 255     


Pro Thr Pro Lys Glu Gln Lys Asp Trp Phe Ile Glu Met Pro Thr Glu 
            260                 265                 270         


Ala Lys Lys Asp Glu Trp Gly Leu Val Ala Pro Ile Ser Pro Gly Pro 
        275                 280                 285             


Leu Thr Pro Met Arg Glu Lys Asp Val Phe Asp Asp Ile Pro Lys Trp 
    290                 295                 300                 


Glu Gly Lys Gln Phe Asp Ser Pro Met Pro Ser Pro Phe Gln Gly Gly 
305                 310                 315                 320 


Ser Phe Thr Leu Pro Leu Asp Val Met Lys Asn Glu Ile Val Thr Glu 
                325                 330                 335     


Thr Ser Pro Phe Ala Pro Ala Phe Leu Gln Pro Asp Asp Lys Lys Ser 
            340                 345                 350         


Leu Gln Gln Thr Ser Gly Pro Ala Thr Ala Lys Asp Ser Phe Lys Ile 
        355                 360                 365             


Glu Glu Pro His Glu Ala Lys Pro Asp Lys Met Ala Glu Ala Pro Pro 
    370                 375                 380                 


Ser Glu Ala Met Thr Leu Pro Lys Asp Ala His Ile Pro Val Val Glu 
385                 390                 395                 400 


Glu His Val Met Gly Lys Val Leu Glu Glu Glu Lys Glu Ala Ile Asn 
                405                 410                 415     


Gln Glu Thr Val Gln Gln Arg Asp Thr Phe Thr Pro Ser Gly Gln Glu 
            420                 425                 430         


Pro Ile Leu Thr Glu Lys Glu Thr Glu Leu Lys Leu Glu Glu Lys Thr 
        435                 440                 445             


Thr Ile Ser Asp Lys Glu Ala Val Pro Lys Glu Ser Lys Pro Pro Lys 
    450                 455                 460                 


Pro Ala Asp Glu Glu Ile Gly Ile Ile Gln Thr Ser Thr Glu His Thr 
465                 470                 475                 480 


Phe Ser Glu Gln Lys Asp Gln Glu Pro Thr Thr Asp Met Leu Lys Gln 
                485                 490                 495     


Asp Ser Phe Pro Val Ser Leu Glu Gln Ala Val Thr Asp Ser Ala Met 
            500                 505                 510         


Thr Ser Lys Thr Leu Glu Lys Ala Met Thr Glu Pro Ser Ala Leu Ile 
        515                 520                 525             


Glu Lys Ser Ser Ile Gln Glu Leu Phe Glu Met Arg Val Asp Asp Lys 
    530                 535                 540                 


Asp Lys Ile Glu Gly Val Gly Ala Ala Thr Ser Ala Glu Leu Asp Met 
545                 550                 555                 560 


Pro Phe Tyr Glu Asp Lys Ser Gly Met Ser Lys Tyr Phe Glu Thr Ser 
                565                 570                 575     


Ala Leu Lys Glu Glu Ala Thr Lys Ser Ile Glu Pro Gly Ser Asp Tyr 
            580                 585                 590         


Tyr Glu Leu Ser Asp Thr Arg Glu Ser Val His Glu Ser Ile Asp Thr 
        595                 600                 605             


Met Ser Pro Met His Lys Asn Gly Asp Lys Glu Phe Gln Thr Gly Lys 
    610                 615                 620                 


Glu Ser Gln Pro Ser Pro Pro Ala Gln Glu Ala Gly Tyr Ser Thr Leu 
625                 630                 635                 640 


Ala Gln Ser Tyr Pro Ser Asp Leu Pro Glu Glu Pro Ser Ser Pro Gln 
                645                 650                 655     


Glu Arg Met Phe Thr Ile Asp Pro Lys Val Tyr Gly Glu Lys Arg Asp 
            660                 665                 670         


Leu His Ser Lys Asn Lys Asp Asp Leu Thr Leu Ser Arg Ser Leu Gly 
        675                 680                 685             


Leu Gly Gly Arg Ser Ala Ile Glu Gln Arg Ser Met Ser Ile Asn Leu 
    690                 695                 700                 


Pro Met Ser Cys Leu Asp Ser Ile Ala Leu Gly Phe Asn Phe Gly Arg 
705                 710                 715                 720 


Gly His Asp Leu Ser Pro Leu Ala Ser Asp Ile Leu Thr Asn Thr Ser 
                725                 730                 735     


Gly Ser Met Asp Glu Gly Asp Asp Tyr Leu Pro Ala Thr Thr Pro Ala 
            740                 745                 750         


Leu Glu Lys Ala Pro Cys Phe Pro Val Glu Ser Lys Glu Glu Glu Gln 
        755                 760                 765             


Ile Glu Lys Val Lys Ala Thr Gly Glu Glu Ser Thr Gln Ala Glu Ile 
    770                 775                 780                 


Ser Cys Glu Ser Pro Phe Leu Ala Lys Asp Phe Tyr Lys Asn Gly Thr 
785                 790                 795                 800 


Val Met Ala Pro Asp Leu Pro Glu Met Leu Asp Leu Ala Gly Thr Arg 
                805                 810                 815     


Ser Arg Leu Ala Ser Val Ser Ala Asp Ala Glu Val Ala Arg Arg Lys 
            820                 825                 830         


Ser Val Pro Ser Glu Thr Val Val Glu Asp Ser Arg Thr Gly Leu Pro 
        835                 840                 845             


Pro Val Thr Asp Glu Asn His Val Ile Val Lys Thr Asp Ser Gln Leu 
    850                 855                 860                 


Glu Asp Leu Gly Tyr Cys Val Phe Asn Lys Tyr Thr Val Pro Leu Pro 
865                 870                 875                 880 


Ser Pro Val Gln Asp Ser Glu Asn Leu Ser Gly Glu Ser Gly Thr Phe 
                885                 890                 895     


Tyr Glu Gly Thr Asp Asp Lys Val Arg Arg Asp Leu Ala Thr Asp Leu 
            900                 905                 910         


Ser Leu Ile Glu Val Lys Leu Ala Ala Ala Gly Arg Val Lys Asp Glu 
        915                 920                 925             


Phe Ser Val Asp Lys Glu Ala Ser Ala His Ile Ser Gly Asp Lys Ser 
    930                 935                 940                 


Gly Leu Ser Lys Glu Phe Asp Gln Glu Lys Lys Ala Asn Asp Arg Leu 
945                 950                 955                 960 


Asp Thr Val Leu Glu Lys Ser Glu Glu His Ala Asp Ser Lys Glu His 
                965                 970                 975     


Ala Lys Lys Thr Glu Glu Ala Gly Asp Glu Ile Glu Thr Phe Gly Leu 
            980                 985                 990         


Gly Val Thr Tyr Glu Gln Ala Leu  Ala Lys Asp Leu Ser  Ile Pro Thr 
        995                 1000                 1005             


Asp Ala  Ser Ser Glu Lys Ala  Glu Lys Gly Leu Ser  Ser Val Pro 
    1010                 1015                 1020             


Glu Ile  Ala Glu Val Glu Pro  Ser Lys Lys Val Glu  Gln Gly Leu 
    1025                 1030                 1035             


Asp Phe  Ala Val Gln Gly Gln  Leu Asp Val Lys Ile  Ser Asp Phe 
    1040                 1045                 1050             


Gly Gln  Met Ala Ser Gly Leu  Asn Ile Asp Asp Arg  Arg Ala Thr 
    1055                 1060                 1065             


Glu Leu  Lys Leu Glu Ala Thr  Gln Asp Met Thr Pro  Ser Ser Lys 
    1070                 1075                 1080             


Ala Pro  Gln Glu Ala Asp Ala  Phe Met Gly Val Glu  Ser Gly His 
    1085                 1090                 1095             


Met Lys  Glu Gly Thr Lys Val  Ser Glu Thr Glu Val  Lys Glu Lys 
    1100                 1105                 1110             


Val Ala  Lys Pro Asp Leu Val  His Gln Glu Ala Val  Asp Lys Glu 
    1115                 1120                 1125             


Glu Ser  Tyr Glu Ser Ser Gly  Glu His Glu Ser Leu  Thr Met Glu 
    1130                 1135                 1140             


Ser Leu  Lys Ala Asp Glu Gly  Lys Lys Glu Thr Ser  Pro Glu Ser 
    1145                 1150                 1155             


Ser Leu  Ile Gln Asp Glu Ile  Ala Val Lys Leu Ser  Val Glu Ile 
    1160                 1165                 1170             


Pro Cys  Pro Pro Ala Val Ser  Glu Ala Asp Leu Ala  Thr Asp Glu 
    1175                 1180                 1185             


Arg Ala  Asp Val Gln Met Glu  Phe Ile Gln Gly Pro  Lys Glu Glu 
    1190                 1195                 1200             


Ser Lys  Glu Thr Pro Asp Ile  Ser Ile Thr Pro Ser  Asp Val Ala 
    1205                 1210                 1215             


Glu Pro  Leu His Glu Thr Ile  Val Ser Glu Pro Ala  Glu Ile Gln 
    1220                 1225                 1230             


Ser Glu  Glu Glu Glu Ile Glu  Ala Gln Gly Glu Tyr  Asp Lys Leu 
    1235                 1240                 1245             


Leu Phe  Arg Ser Asp Thr Leu  Gln Ile Thr Asp Leu  Gly Val Ser 
    1250                 1255                 1260             


Gly Ala  Arg Glu Glu Phe Val  Glu Thr Cys Pro Ser  Glu His Lys 
    1265                 1270                 1275             


Gly Val  Ile Glu Ser Val Val  Thr Ile Glu Asp Asp  Phe Ile Thr 
    1280                 1285                 1290             


Val Val  Gln Thr Thr Thr Asp  Glu Gly Glu Ser Gly  Ser His Ser 
    1295                 1300                 1305             


Val Arg  Phe Ala Ala Leu Glu  Gln Pro Glu Val Glu  Arg Arg Pro 
    1310                 1315                 1320             


Ser Pro  His Asp Glu Glu Glu  Phe Glu Val Glu Glu  Ala Ala Glu 
    1325                 1330                 1335             


Ala Gln  Ala Glu Pro Lys Asp  Gly Ser Pro Glu Ala  Pro Ala Ser 
    1340                 1345                 1350             


Pro Glu  Arg Glu Glu Val Ala  Leu Ser Glu Tyr Lys  Thr Glu Thr 
    1355                 1360                 1365             


Tyr Asp  Asp Tyr Lys Asp Glu  Thr Thr Ile Asp Asp  Ser Ile Met 
    1370                 1375                 1380             


Asp Ala  Asp Ser Leu Trp Val  Asp Thr Gln Asp Asp  Asp Arg Ser 
    1385                 1390                 1395             


Ile Met  Thr Glu Gln Leu Glu  Thr Ile Pro Lys Glu  Glu Lys Ala 
    1400                 1405                 1410             


Glu Lys  Glu Ala Arg Arg Ser  Ser Leu Glu Lys His  Arg Lys Glu 
    1415                 1420                 1425             


Lys Pro  Phe Lys Thr Gly Arg  Gly Arg Ile Ser Thr  Pro Glu Arg 
    1430                 1435                 1440             


Lys Val  Ala Lys Lys Glu Pro  Ser Thr Val Ser Arg  Asp Glu Val 
    1445                 1450                 1455             


Arg Arg  Lys Lys Ala Val Tyr  Lys Lys Ala Glu Leu  Ala Lys Lys 
    1460                 1465                 1470             


Thr Glu  Val Gln Ala His Ser  Pro Ser Arg Lys Phe  Ile Leu Lys 
    1475                 1480                 1485             


Pro Ala  Ile Lys Tyr Thr Arg  Pro Thr His Leu Ser  Cys Val Lys 
    1490                 1495                 1500             


Arg Lys  Thr Thr Ala Ala Gly  Gly Glu Ser Ala Leu  Ala Pro Ser 
    1505                 1510                 1515             


Val Phe  Lys Gln Ala Lys Asp  Lys Val Ser Asp Gly  Val Thr Lys 
    1520                 1525                 1530             


Ser Pro  Glu Lys Arg Ser Ser  Leu Pro Arg Pro Ser  Ser Ile Leu 
    1535                 1540                 1545             


Pro Pro  Arg Arg Gly Val Ser  Gly Asp Arg Asp Glu  Asn Ser Phe 
    1550                 1555                 1560             


Ser Leu  Asn Ser Ser Ile Ser  Ser Ser Ala Arg Arg  Thr Thr Arg 
    1565                 1570                 1575             


Ser Glu  Pro Ile Arg Arg Ala  Gly Lys Ser Gly Thr  Ser Thr Pro 
    1580                 1585                 1590             


Thr Thr  Pro Gly Ser Thr Ala  Ile Thr Pro Gly Thr  Pro Pro Ser 
    1595                 1600                 1605             


Tyr Ser  Ser Arg Thr Pro Gly  Thr Pro Gly Thr Pro  Ser Tyr Pro 
    1610                 1615                 1620             


Arg Thr  Pro His Thr Pro Gly  Thr Pro Lys Ser Ala  Ile Leu Val 
    1625                 1630                 1635             


Pro Ser  Glu Lys Lys Val Ala  Ile Ile Arg Thr Pro  Pro Lys Ser 
    1640                 1645                 1650             


Pro Ala  Thr Pro Lys Gln Leu  Arg Leu Ile Asn Gln  Pro Leu Pro 
    1655                 1660                 1665             


Asp Leu  Lys Asn Val Lys Ser  Lys Ile Gly Ser Thr  Asp Asn Ile 
    1670                 1675                 1680             


Lys Tyr  Gln Pro Lys Gly Gly  Gln Val Gln Ile Val  Thr Lys Lys 
    1685                 1690                 1695             


Ile Asp  Leu Ser His Val Thr  Ser Lys Cys Gly Ser  Leu Lys Asn 
    1700                 1705                 1710             


Ile Arg  His Arg Pro Gly Gly  Gly Arg Val Lys Ile  Glu Ser Val 
    1715                 1720                 1725             


Lys Leu  Asp Phe Lys Glu Lys  Ala Gln Ala Lys Val  Gly Ser Leu 
    1730                 1735                 1740             


Asp Asn  Ala His His Val Pro  Gly Gly Gly Asn Val  Lys Ile Asp 
    1745                 1750                 1755             


Ser Gln  Lys Leu Asn Phe Arg  Glu His Ala Lys Ala  Arg Val Asp 
    1760                 1765                 1770             


His Gly  Ala Glu Ile Ile Thr  Gln Ser Pro Gly Arg  Ser Ser Val 
    1775                 1780                 1785             


Ala Ser  Pro Arg Arg Leu Ser  Asn Val Ser Ser Ser  Gly Ser Ile 
    1790                 1795                 1800             


Asn Leu  Leu Glu Ser Pro Gln  Leu Ala Thr Leu Ala  Glu Asp Val 
    1805                 1810                 1815             


Thr Ala  Ala Leu Ala Lys Gln  Gly Leu 
    1820                 1825         


<210>  327
<211>  708
<212>  PRT
<213>  Homo sapiens

<400>  327

Met Ser Thr Ala Asp Ala Leu Asp Asp Glu Asn Thr Phe Lys Ile Leu 
1               5                   10                  15      


Val Ala Thr Asp Ile His Leu Gly Phe Met Glu Lys Asp Ala Val Arg 
            20                  25                  30          


Gly Asn Asp Thr Phe Val Thr Leu Asp Glu Ile Leu Arg Leu Ala Gln 
        35                  40                  45              


Glu Asn Glu Val Asp Phe Ile Leu Leu Gly Gly Asp Leu Phe His Glu 
    50                  55                  60                  


Asn Lys Pro Ser Arg Lys Thr Leu His Thr Cys Leu Glu Leu Leu Arg 
65                  70                  75                  80  


Lys Tyr Cys Met Gly Asp Arg Pro Val Gln Phe Glu Ile Leu Ser Asp 
                85                  90                  95      


Gln Ser Val Asn Phe Gly Phe Ser Lys Phe Pro Trp Val Asn Tyr Gln 
            100                 105                 110         


Asp Gly Asn Leu Asn Ile Ser Ile Pro Val Phe Ser Ile His Gly Asn 
        115                 120                 125             


His Asp Asp Pro Thr Gly Ala Asp Ala Leu Cys Ala Leu Asp Ile Leu 
    130                 135                 140                 


Ser Cys Ala Gly Phe Val Asn His Phe Gly Arg Ser Met Ser Val Glu 
145                 150                 155                 160 


Lys Ile Asp Ile Ser Pro Val Leu Leu Gln Lys Gly Ser Thr Lys Ile 
                165                 170                 175     


Ala Leu Tyr Gly Leu Gly Ser Ile Pro Asp Glu Arg Leu Tyr Arg Met 
            180                 185                 190         


Phe Val Asn Lys Lys Val Thr Met Leu Arg Pro Lys Glu Asp Glu Asn 
        195                 200                 205             


Ser Trp Phe Asn Leu Phe Val Ile His Gln Asn Arg Ser Lys His Gly 
    210                 215                 220                 


Ser Thr Asn Phe Ile Pro Glu Gln Phe Leu Asp Asp Phe Ile Asp Leu 
225                 230                 235                 240 


Val Ile Trp Gly His Glu His Glu Cys Lys Ile Ala Pro Thr Lys Asn 
                245                 250                 255     


Glu Gln Gln Leu Phe Tyr Ile Ser Gln Pro Gly Ser Ser Val Val Thr 
            260                 265                 270         


Ser Leu Ser Pro Gly Glu Ala Val Lys Lys His Val Gly Leu Leu Arg 
        275                 280                 285             


Ile Lys Gly Arg Lys Met Asn Met His Lys Ile Pro Leu His Thr Val 
    290                 295                 300                 


Arg Gln Phe Phe Met Glu Asp Ile Val Leu Ala Asn His Pro Asp Ile 
305                 310                 315                 320 


Phe Asn Pro Asp Asn Pro Lys Val Thr Gln Ala Ile Gln Ser Phe Cys 
                325                 330                 335     


Leu Glu Lys Ile Glu Glu Met Leu Glu Asn Ala Glu Arg Glu Arg Leu 
            340                 345                 350         


Gly Asn Ser His Gln Pro Glu Lys Pro Leu Val Arg Leu Arg Val Asp 
        355                 360                 365             


Tyr Ser Gly Gly Phe Glu Pro Phe Ser Val Leu Arg Phe Ser Gln Lys 
    370                 375                 380                 


Phe Val Asp Arg Val Ala Asn Pro Lys Asp Ile Ile His Phe Phe Arg 
385                 390                 395                 400 


His Arg Glu Gln Lys Glu Lys Thr Gly Glu Glu Ile Asn Phe Gly Lys 
                405                 410                 415     


Leu Ile Thr Lys Pro Ser Glu Gly Thr Thr Leu Arg Val Glu Asp Leu 
            420                 425                 430         


Val Lys Gln Tyr Phe Gln Thr Ala Glu Lys Asn Val Gln Leu Ser Leu 
        435                 440                 445             


Leu Thr Glu Arg Gly Met Gly Glu Ala Val Gln Glu Phe Val Asp Lys 
    450                 455                 460                 


Glu Glu Lys Asp Ala Ile Glu Glu Leu Val Lys Tyr Gln Leu Glu Lys 
465                 470                 475                 480 


Thr Gln Arg Phe Leu Lys Glu Arg His Ile Asp Ala Leu Glu Asp Lys 
                485                 490                 495     


Ile Asp Glu Glu Val Arg Arg Phe Arg Glu Thr Arg Gln Lys Asn Thr 
            500                 505                 510         


Asn Glu Glu Asp Asp Glu Val Arg Glu Ala Met Thr Arg Ala Arg Ala 
        515                 520                 525             


Leu Arg Ser Gln Ser Glu Glu Ser Ala Ser Ala Phe Ser Ala Asp Asp 
    530                 535                 540                 


Leu Met Ser Ile Asp Leu Ala Glu Gln Met Ala Asn Asp Ser Asp Asp 
545                 550                 555                 560 


Ser Ile Ser Ala Ala Thr Asn Lys Gly Arg Gly Arg Gly Arg Gly Arg 
                565                 570                 575     


Arg Gly Gly Arg Gly Gln Asn Ser Ala Ser Arg Gly Gly Ser Gln Arg 
            580                 585                 590         


Gly Arg Ala Asp Thr Gly Leu Glu Thr Ser Thr Arg Ser Arg Asn Ser 
        595                 600                 605             


Lys Thr Ala Val Ser Ala Ser Arg Asn Met Ser Ile Ile Asp Ala Phe 
    610                 615                 620                 


Lys Ser Thr Arg Gln Gln Pro Ser Arg Asn Val Thr Thr Lys Asn Tyr 
625                 630                 635                 640 


Ser Glu Val Ile Glu Val Asp Glu Ser Asp Val Glu Glu Asp Ile Phe 
                645                 650                 655     


Pro Thr Thr Ser Lys Thr Asp Gln Arg Trp Ser Ser Thr Ser Ser Ser 
            660                 665                 670         


Lys Ile Met Ser Gln Ser Gln Val Ser Lys Gly Val Asp Phe Glu Ser 
        675                 680                 685             


Ser Glu Asp Asp Asp Asp Asp Pro Phe Met Asn Thr Ser Ser Leu Arg 
    690                 695                 700                 


Arg Asn Arg Arg 
705             


<210>  328
<211>  608
<212>  PRT
<213>  Homo sapiens

<400>  328

Met Ser Gln Glu Gly Asp Tyr Gly Arg Trp Thr Ile Ser Ser Ser Asp 
1               5                   10                  15      


Glu Ser Glu Glu Glu Lys Pro Lys Pro Asp Lys Pro Ser Thr Ser Ser 
            20                  25                  30          


Leu Leu Cys Ala Arg Gln Gly Ala Ala Asn Glu Pro Arg Tyr Thr Cys 
        35                  40                  45              


Ser Glu Ala Gln Lys Ala Ala His Lys Arg Lys Ile Ser Pro Val Lys 
    50                  55                  60                  


Phe Ser Asn Thr Asp Ser Val Leu Pro Pro Lys Arg Gln Lys Ser Gly 
65                  70                  75                  80  


Ser Gln Glu Asp Leu Gly Trp Cys Leu Ser Ser Ser Asp Asp Glu Leu 
                85                  90                  95      


Gln Pro Glu Met Pro Gln Lys Gln Ala Glu Lys Val Val Ile Lys Lys 
            100                 105                 110         


Glu Lys Asp Ile Ser Ala Pro Asn Asp Gly Thr Ala Gln Arg Thr Glu 
        115                 120                 125             


Asn His Gly Ala Pro Ala Cys His Arg Leu Lys Glu Glu Glu Asp Glu 
    130                 135                 140                 


Tyr Glu Thr Ser Gly Glu Gly Gln Asp Ile Trp Asp Met Leu Asp Lys 
145                 150                 155                 160 


Gly Asn Pro Phe Gln Phe Tyr Leu Thr Arg Val Ser Gly Val Lys Pro 
                165                 170                 175     


Lys Tyr Asn Ser Gly Ala Leu His Ile Lys Asp Ile Leu Ser Pro Leu 
            180                 185                 190         


Phe Gly Thr Leu Val Ser Ser Ala Gln Phe Asn Tyr Cys Phe Asp Val 
        195                 200                 205             


Asp Trp Leu Val Lys Gln Tyr Pro Pro Glu Phe Arg Lys Lys Pro Ile 
    210                 215                 220                 


Leu Leu Val His Gly Asp Lys Arg Glu Ala Lys Ala His Leu His Ala 
225                 230                 235                 240 


Gln Ala Lys Pro Tyr Glu Asn Ile Ser Leu Cys Gln Ala Lys Leu Asp 
                245                 250                 255     


Ile Ala Phe Gly Thr His His Thr Lys Met Met Leu Leu Leu Tyr Glu 
            260                 265                 270         


Glu Gly Leu Arg Val Val Ile His Thr Ser Asn Leu Ile His Ala Asp 
        275                 280                 285             


Trp His Gln Lys Thr Gln Gly Ile Trp Leu Ser Pro Leu Tyr Pro Arg 
    290                 295                 300                 


Ile Ala Asp Gly Thr His Lys Ser Gly Glu Ser Pro Thr His Phe Lys 
305                 310                 315                 320 


Ala Asp Leu Ile Ser Tyr Leu Met Ala Tyr Asn Ala Pro Ser Leu Lys 
                325                 330                 335     


Glu Trp Ile Asp Val Ile His Lys His Asp Leu Ser Glu Thr Asn Val 
            340                 345                 350         


Tyr Leu Ile Gly Ser Thr Pro Gly Arg Phe Gln Gly Ser Gln Lys Asp 
        355                 360                 365             


Asn Trp Gly His Phe Arg Leu Lys Lys Leu Leu Lys Asp His Ala Ser 
    370                 375                 380                 


Ser Met Pro Asn Ala Glu Ser Trp Pro Val Val Gly Gln Phe Ser Ser 
385                 390                 395                 400 


Val Gly Ser Leu Gly Ala Asp Glu Ser Lys Trp Leu Cys Ser Glu Phe 
                405                 410                 415     


Lys Glu Ser Met Leu Thr Leu Gly Lys Glu Ser Lys Thr Pro Gly Lys 
            420                 425                 430         


Ser Ser Val Pro Leu Tyr Leu Ile Tyr Pro Ser Val Glu Asn Val Arg 
        435                 440                 445             


Thr Ser Leu Glu Gly Tyr Pro Ala Gly Gly Ser Leu Pro Tyr Ser Ile 
    450                 455                 460                 


Gln Thr Ala Glu Lys Gln Asn Trp Leu His Ser Tyr Phe His Lys Trp 
465                 470                 475                 480 


Ser Ala Glu Thr Ser Gly Arg Ser Asn Ala Met Pro His Ile Lys Thr 
                485                 490                 495     


Tyr Met Arg Pro Ser Pro Asp Phe Ser Lys Ile Ala Trp Phe Leu Val 
            500                 505                 510         


Thr Ser Ala Asn Leu Ser Lys Ala Ala Trp Gly Ala Leu Glu Lys Asn 
        515                 520                 525             


Gly Thr Gln Leu Met Ile Arg Ser Tyr Glu Leu Gly Val Leu Phe Leu 
    530                 535                 540                 


Pro Ser Ala Phe Gly Leu Asp Ser Phe Lys Val Lys Gln Lys Phe Phe 
545                 550                 555                 560 


Ala Gly Ser Gln Glu Pro Met Ala Thr Phe Pro Val Pro Tyr Asp Leu 
                565                 570                 575     


Pro Pro Glu Leu Tyr Gly Ser Lys Asp Arg Pro Trp Ile Trp Asn Ile 
            580                 585                 590         


Pro Tyr Val Lys Ala Pro Asp Thr His Gly Asn Met Trp Val Pro Ser 
        595                 600                 605             


<210>  329
<211>  514
<212>  PRT
<213>  Homo sapiens

<400>  329

Met Glu Asp Ser Glu Phe Leu Ala Tyr Val Glu Leu Leu Asp Glu Val 
1               5                   10                  15      


Glu Gln Gly Ser Val Arg Ala Lys Ala Ser Ser Val Ser Leu His Ala 
            20                  25                  30          


Glu Arg Thr Trp Met Glu Lys Met Lys Val Glu Asp Leu Asn Val Cys 
        35                  40                  45              


Glu Pro Ala Ser Pro Ala Pro Glu Ala Pro Ala Thr Ser Leu Leu Asn 
    50                  55                  60                  


Asp Leu Lys Tyr Ser Pro Ser Glu Glu Glu Glu Val Thr Tyr Thr Val 
65                  70                  75                  80  


Ile Asn Gln Phe Gln Gln Lys Phe Gly Ala Ala Ile Leu His Ile Lys 
                85                  90                  95      


Lys Gln Asn Val Leu Ser Val Ala Ala Glu Gly Ala Asn Val Cys Arg 
            100                 105                 110         


His Gly Lys Leu Cys Trp Leu Gln Val Ala Thr Asn Cys Arg Val Tyr 
        115                 120                 125             


Leu Phe Asp Ile Phe Leu Leu Gly Ser Arg Ala Phe His Asn Gly Leu 
    130                 135                 140                 


Gln Met Ile Leu Glu Asp Lys Arg Ile Leu Lys Val Ile His Asp Cys 
145                 150                 155                 160 


Arg Trp Leu Ser Asp Cys Leu Ser His Gln Tyr Gly Ile Leu Leu Asn 
                165                 170                 175     


Asn Val Phe Asp Thr Gln Val Ala Asp Val Leu Gln Phe Ser Met Glu 
            180                 185                 190         


Thr Gly Gly Tyr Leu Pro Asn Cys Ile Thr Thr Leu Gln Glu Ser Leu 
        195                 200                 205             


Ile Lys His Leu Gln Val Ala Pro Lys Tyr Leu Ser Phe Leu Glu Lys 
    210                 215                 220                 


Arg Gln Lys Leu Ile Gln Glu Asn Pro Glu Val Trp Phe Ile Arg Pro 
225                 230                 235                 240 


Val Ser Pro Ser Leu Leu Lys Ile Leu Ala Leu Glu Ala Thr Tyr Leu 
                245                 250                 255     


Leu Pro Leu Arg Leu Ala Leu Leu Asp Glu Met Met Ser Asp Leu Thr 
            260                 265                 270         


Thr Leu Val Asp Gly Tyr Leu Asn Thr Tyr Arg Glu Gly Ser Ala Asp 
        275                 280                 285             


Arg Leu Gly Gly Thr Glu Pro Thr Cys Met Glu Leu Pro Glu Glu Leu 
    290                 295                 300                 


Leu Gln Leu Lys Asp Phe Gln Lys Gln Arg Arg Glu Lys Ala Ala Arg 
305                 310                 315                 320 


Glu Tyr Arg Val Asn Ala Gln Gly Leu Leu Ile Arg Thr Val Leu Gln 
                325                 330                 335     


Pro Lys Lys Leu Val Thr Glu Thr Ala Gly Lys Glu Glu Lys Val Lys 
            340                 345                 350         


Gly Phe Leu Phe Gly Lys Asn Phe Arg Ile Asp Lys Ala Pro Ser Phe 
        355                 360                 365             


Thr Ser Gln Asp Phe His Gly Asp Val Asn Leu Leu Lys Glu Glu Ser 
    370                 375                 380                 


Leu Asn Lys Gln Ala Thr Asn Pro Gln His Leu Pro Pro Thr Glu Glu 
385                 390                 395                 400 


Gly Glu Thr Ser Glu Asp Ser Ser Asn Lys Leu Ile Cys Thr Lys Ser 
                405                 410                 415     


Lys Gly Ser Glu Asp Gln Arg Ile Thr Gln Lys Glu His Phe Met Thr 
            420                 425                 430         


Pro Lys His Glu Phe Gln Ala Ser Leu Ser Leu Lys Glu Glu Thr Glu 
        435                 440                 445             


Gln Leu Leu Met Val Glu Asn Lys Glu Asp Leu Lys Cys Thr Lys Gln 
    450                 455                 460                 


Ala Val Ser Met Ser Ser Phe Pro Gln Glu Thr Arg Val Ser Pro Ser 
465                 470                 475                 480 


Asp Thr Phe Tyr Pro Ile Arg Lys Ala Val Val Ser Thr Leu Pro Pro 
                485                 490                 495     


Cys Pro Ala Leu Glu Lys Ile Asp Ser Trp Ile Ser Pro Phe Leu Asn 
            500                 505                 510         


Leu Pro 
        


<210>  330
<211>  424
<212>  PRT
<213>  Homo sapiens

<400>  330

Met Ser Asp Ser Lys Cys Asp Ser Gln Phe Tyr Ser Val Gln Val Ala 
1               5                   10                  15      


Asp Ser Thr Phe Thr Val Leu Lys Arg Tyr Gln Gln Leu Lys Pro Ile 
            20                  25                  30          


Gly Ser Gly Ala Gln Gly Ile Val Cys Ala Ala Phe Asp Thr Val Leu 
        35                  40                  45              


Gly Ile Asn Val Ala Val Lys Lys Leu Ser Arg Pro Phe Gln Asn Gln 
    50                  55                  60                  


Thr His Ala Lys Arg Ala Tyr Arg Glu Leu Val Leu Leu Lys Cys Val 
65                  70                  75                  80  


Asn His Lys Asn Ile Ile Ser Leu Leu Asn Val Phe Thr Pro Gln Lys 
                85                  90                  95      


Thr Leu Glu Glu Phe Gln Asp Val Tyr Leu Val Met Glu Leu Met Asp 
            100                 105                 110         


Ala Asn Leu Cys Gln Val Ile His Met Glu Leu Asp His Glu Arg Met 
        115                 120                 125             


Ser Tyr Leu Leu Tyr Gln Met Leu Cys Gly Ile Lys His Leu His Ser 
    130                 135                 140                 


Ala Gly Ile Ile His Arg Asp Leu Lys Pro Ser Asn Ile Val Val Lys 
145                 150                 155                 160 


Ser Asp Cys Thr Leu Lys Ile Leu Asp Phe Gly Leu Ala Arg Thr Ala 
                165                 170                 175     


Cys Thr Asn Phe Met Met Thr Pro Tyr Val Val Thr Arg Tyr Tyr Arg 
            180                 185                 190         


Ala Pro Glu Val Ile Leu Gly Met Gly Tyr Lys Glu Asn Val Asp Ile 
        195                 200                 205             


Trp Ser Val Gly Cys Ile Met Gly Glu Leu Val Lys Gly Cys Val Ile 
    210                 215                 220                 


Phe Gln Gly Thr Asp His Ile Asp Gln Trp Asn Lys Val Ile Glu Gln 
225                 230                 235                 240 


Leu Gly Thr Pro Ser Ala Glu Phe Met Lys Lys Leu Gln Pro Thr Val 
                245                 250                 255     


Arg Asn Tyr Val Glu Asn Arg Pro Lys Tyr Pro Gly Ile Lys Phe Glu 
            260                 265                 270         


Glu Leu Phe Pro Asp Trp Ile Phe Pro Ser Glu Ser Glu Arg Asp Lys 
        275                 280                 285             


Ile Lys Thr Ser Gln Ala Arg Asp Leu Leu Ser Lys Met Leu Val Ile 
    290                 295                 300                 


Asp Pro Asp Lys Arg Ile Ser Val Asp Glu Ala Leu Arg His Pro Tyr 
305                 310                 315                 320 


Ile Thr Val Trp Tyr Asp Pro Ala Glu Ala Glu Ala Pro Pro Pro Gln 
                325                 330                 335     


Ile Tyr Asp Ala Gln Leu Glu Glu Arg Glu His Ala Ile Glu Glu Trp 
            340                 345                 350         


Lys Glu Leu Ile Tyr Lys Glu Val Met Asp Trp Glu Glu Arg Ser Lys 
        355                 360                 365             


Asn Gly Val Val Lys Asp Gln Pro Ser Asp Ala Ala Val Ser Ser Asn 
    370                 375                 380                 


Ala Thr Pro Ser Gln Ser Ser Ser Ile Asn Asp Ile Ser Ser Met Ser 
385                 390                 395                 400 


Thr Glu Gln Thr Leu Ala Ser Asp Thr Asp Ser Ser Leu Asp Ala Ser 
                405                 410                 415     


Thr Gly Pro Leu Glu Gly Cys Arg 
            420                 


<210>  331
<211>  301
<212>  PRT
<213>  Homo sapiens

<400>  331

Met Glu Gly Asp Phe Ser Val Cys Arg Asn Cys Lys Arg His Val Val 
1               5                   10                  15      


Ser Ala Asn Phe Thr Leu His Glu Ala Tyr Cys Leu Arg Phe Leu Val 
            20                  25                  30          


Leu Cys Pro Glu Cys Glu Glu Pro Val Pro Lys Glu Thr Met Glu Glu 
        35                  40                  45              


His Cys Lys Leu Glu His Gln Gln Val Gly Cys Thr Met Cys Gln Gln 
    50                  55                  60                  


Ser Met Gln Lys Ser Ser Leu Glu Phe His Lys Ala Asn Glu Cys Gln 
65                  70                  75                  80  


Glu Arg Pro Val Glu Cys Lys Phe Cys Lys Leu Asp Met Gln Leu Ser 
                85                  90                  95      


Lys Leu Glu Leu His Glu Ser Tyr Cys Gly Ser Arg Thr Glu Leu Cys 
            100                 105                 110         


Gln Gly Cys Gly Gln Phe Ile Met His Arg Met Leu Ala Gln His Arg 
        115                 120                 125             


Asp Val Cys Arg Ser Glu Gln Ala Gln Leu Gly Lys Gly Glu Arg Ile 
    130                 135                 140                 


Ser Ala Pro Glu Arg Glu Ile Tyr Cys His Tyr Cys Asn Gln Met Ile 
145                 150                 155                 160 


Pro Glu Asn Lys Tyr Phe His His Met Gly Lys Cys Cys Pro Asp Ser 
                165                 170                 175     


Glu Phe Lys Lys His Phe Pro Val Gly Asn Pro Glu Ile Leu Pro Ser 
            180                 185                 190         


Ser Leu Pro Ser Gln Ala Ala Glu Asn Gln Thr Ser Thr Met Glu Lys 
        195                 200                 205             


Asp Val Arg Pro Lys Thr Arg Ser Ile Asn Arg Phe Pro Leu His Ser 
    210                 215                 220                 


Glu Ser Ser Ser Lys Lys Ala Pro Arg Ser Lys Asn Lys Thr Leu Asp 
225                 230                 235                 240 


Pro Leu Leu Met Ser Glu Pro Lys Pro Arg Thr Ser Ser Pro Arg Gly 
                245                 250                 255     


Asp Lys Ala Ala Tyr Asp Ile Leu Arg Arg Cys Ser Gln Cys Gly Ile 
            260                 265                 270         


Leu Leu Pro Leu Pro Ile Leu Asn Gln His Gln Glu Lys Cys Arg Trp 
        275                 280                 285             


Leu Ala Ser Ser Lys Gly Lys Gln Val Arg Asn Phe Ser 
    290                 295                 300     


<210>  332
<211>  545
<212>  PRT
<213>  Homo sapiens

<400>  332

Met Gly Gln Val Leu Pro Val Phe Ala His Cys Lys Glu Ala Pro Ser 
1               5                   10                  15      


Thr Ala Ser Ser Thr Pro Asp Ser Thr Glu Gly Gly Asn Asp Asp Ser 
            20                  25                  30          


Asp Phe Arg Glu Leu His Thr Ala Arg Glu Phe Ser Glu Glu Asp Glu 
        35                  40                  45              


Glu Glu Thr Thr Ser Gln Asp Trp Gly Thr Pro Arg Glu Leu Thr Phe 
    50                  55                  60                  


Ser Tyr Ile Ala Phe Asp Gly Val Val Gly Ser Gly Gly Arg Arg Asp 
65                  70                  75                  80  


Ser Thr Ala Arg Arg Pro Arg Pro Gln Gly Arg Ser Val Ser Glu Pro 
                85                  90                  95      


Arg Asp Gln His Pro Gln Pro Ser Leu Gly Asp Ser Leu Glu Ser Ile 
            100                 105                 110         


Pro Ser Leu Ser Gln Ser Pro Glu Pro Gly Arg Arg Gly Asp Pro Asp 
        115                 120                 125             


Thr Ala Pro Pro Ser Glu Arg Pro Leu Glu Asp Leu Arg Leu Arg Leu 
    130                 135                 140                 


Asp His Leu Gly Trp Val Ala Arg Gly Thr Gly Ser Gly Glu Asp Ser 
145                 150                 155                 160 


Ser Thr Ser Ser Ser Thr Pro Leu Glu Asp Glu Glu Pro Gln Glu Pro 
                165                 170                 175     


Asn Arg Leu Glu Thr Gly Glu Ala Gly Glu Glu Leu Asp Leu Arg Leu 
            180                 185                 190         


Arg Leu Ala Gln Pro Ser Ser Pro Glu Val Leu Thr Pro Gln Leu Ser 
        195                 200                 205             


Pro Gly Ser Gly Thr Pro Gln Ala Gly Thr Pro Ser Pro Ser Arg Ser 
    210                 215                 220                 


Arg Asp Ser Asn Ser Gly Pro Glu Glu Pro Leu Leu Glu Glu Glu Glu 
225                 230                 235                 240 


Lys Gln Trp Gly Pro Leu Glu Arg Glu Pro Val Arg Gly Gln Cys Leu 
                245                 250                 255     


Asp Ser Thr Asp Gln Leu Glu Phe Thr Val Glu Pro Arg Leu Leu Gly 
            260                 265                 270         


Thr Ala Met Glu Trp Leu Lys Thr Ser Leu Leu Leu Ala Val Tyr Lys 
        275                 280                 285             


Thr Val Pro Ile Leu Glu Leu Ser Pro Pro Leu Trp Thr Ala Ile Gly 
    290                 295                 300                 


Trp Val Gln Arg Gly Pro Thr Pro Pro Thr Pro Val Leu Arg Val Leu 
305                 310                 315                 320 


Leu Lys Trp Ala Lys Ser Pro Arg Ser Ser Gly Val Pro Ser Leu Ser 
                325                 330                 335     


Leu Gly Ala Asp Met Gly Ser Lys Val Ala Asp Leu Leu Tyr Trp Lys 
            340                 345                 350         


Asp Thr Arg Thr Ser Gly Val Val Phe Thr Gly Leu Met Val Ser Leu 
        355                 360                 365             


Leu Cys Leu Leu His Phe Ser Ile Val Ser Val Ala Ala His Leu Ala 
    370                 375                 380                 


Leu Leu Leu Leu Cys Gly Thr Ile Ser Leu Arg Val Tyr Arg Lys Val 
385                 390                 395                 400 


Leu Gln Ala Val His Arg Gly Asp Gly Ala Asn Pro Phe Gln Ala Tyr 
                405                 410                 415     


Leu Asp Val Asp Leu Thr Leu Thr Arg Glu Gln Thr Glu Arg Leu Ser 
            420                 425                 430         


His Gln Ile Thr Ser Arg Val Val Ser Ala Ala Thr Gln Leu Arg His 
        435                 440                 445             


Phe Phe Leu Val Glu Asp Leu Val Asp Ser Leu Lys Leu Ala Leu Leu 
    450                 455                 460                 


Phe Tyr Ile Leu Thr Phe Val Gly Ala Ile Phe Asn Gly Leu Thr Leu 
465                 470                 475                 480 


Leu Ile Leu Gly Val Ile Gly Leu Phe Thr Ile Pro Leu Leu Tyr Arg 
                485                 490                 495     


Gln His Gln Ala Gln Ile Asp Gln Tyr Val Gly Leu Val Thr Asn Gln 
            500                 505                 510         


Leu Ser His Ile Lys Ala Lys Ile Arg Ala Lys Ile Pro Gly Thr Gly 
        515                 520                 525             


Ala Leu Ala Ser Ala Ala Ala Ala Val Ser Gly Ser Lys Ala Lys Ala 
    530                 535                 540                 


Glu 
545 


<210>  333
<211>  398
<212>  PRT
<213>  Homo sapiens

<400>  333

Met Ala Leu Leu Arg Arg Pro Thr Val Ser Ser Asp Leu Glu Asn Ile 
1               5                   10                  15      


Asp Thr Gly Val Asn Ser Lys Val Lys Ser His Val Thr Ile Arg Arg 
            20                  25                  30          


Thr Val Leu Glu Glu Ile Gly Asn Arg Val Thr Thr Arg Ala Ala Gln 
        35                  40                  45              


Val Ala Lys Lys Ala Gln Asn Thr Lys Val Pro Val Gln Pro Thr Lys 
    50                  55                  60                  


Thr Thr Asn Val Asn Lys Gln Leu Lys Pro Thr Ala Ser Val Lys Pro 
65                  70                  75                  80  


Val Gln Met Glu Lys Leu Ala Pro Lys Gly Pro Ser Pro Thr Pro Glu 
                85                  90                  95      


Asp Val Ser Met Lys Glu Glu Asn Leu Cys Gln Ala Phe Ser Asp Ala 
            100                 105                 110         


Leu Leu Cys Lys Ile Glu Asp Ile Asp Asn Glu Asp Trp Glu Asn Pro 
        115                 120                 125             


Gln Leu Cys Ser Asp Tyr Val Lys Asp Ile Tyr Gln Tyr Leu Arg Gln 
    130                 135                 140                 


Leu Glu Val Leu Gln Ser Ile Asn Pro His Phe Leu Asp Gly Arg Asp 
145                 150                 155                 160 


Ile Asn Gly Arg Met Arg Ala Ile Leu Val Asp Trp Leu Val Gln Val 
                165                 170                 175     


His Ser Lys Phe Arg Leu Leu Gln Glu Thr Leu Tyr Met Cys Val Gly 
            180                 185                 190         


Ile Met Asp Arg Phe Leu Gln Val Gln Pro Val Ser Arg Lys Lys Leu 
        195                 200                 205             


Gln Leu Val Gly Ile Thr Ala Leu Leu Leu Ala Ser Lys Tyr Glu Glu 
    210                 215                 220                 


Met Phe Ser Pro Asn Ile Glu Asp Phe Val Tyr Ile Thr Asp Asn Ala 
225                 230                 235                 240 


Tyr Thr Ser Ser Gln Ile Arg Glu Met Glu Thr Leu Ile Leu Lys Glu 
                245                 250                 255     


Leu Lys Phe Glu Leu Gly Arg Pro Leu Pro Leu His Phe Leu Arg Arg 
            260                 265                 270         


Ala Ser Lys Ala Gly Glu Val Asp Val Glu Gln His Thr Leu Ala Lys 
        275                 280                 285             


Tyr Leu Met Glu Leu Thr Leu Ile Asp Tyr Asp Met Val His Tyr His 
    290                 295                 300                 


Pro Ser Lys Val Ala Ala Ala Ala Ser Cys Leu Ser Gln Lys Val Leu 
305                 310                 315                 320 


Gly Gln Gly Lys Trp Asn Leu Lys Gln Gln Tyr Tyr Thr Gly Tyr Thr 
                325                 330                 335     


Glu Asn Glu Val Leu Glu Val Met Gln His Met Ala Lys Asn Val Val 
            340                 345                 350         


Lys Val Asn Glu Asn Leu Thr Lys Phe Ile Ala Ile Lys Asn Lys Tyr 
        355                 360                 365             


Ala Ser Ser Lys Leu Leu Lys Ile Ser Met Ile Pro Gln Leu Asn Ser 
    370                 375                 380                 


Lys Ala Val Lys Asp Leu Ala Ser Pro Leu Ile Gly Arg Ser 
385                 390                 395             


<210>  334
<211>  441
<212>  PRT
<213>  Homo sapiens

<400>  334

Met Lys Lys Phe Phe Gln Glu Phe Lys Ala Asp Ile Lys Phe Lys Ser 
1               5                   10                  15      


Ala Gly Pro Gly Gln Lys Leu Lys Glu Ser Val Gly Glu Lys Ala His 
            20                  25                  30          


Lys Glu Lys Pro Asn Gln Pro Ala Pro Arg Pro Pro Arg Gln Gly Pro 
        35                  40                  45              


Thr Asn Glu Ala Gln Met Ala Ala Ala Ala Ala Leu Ala Arg Leu Glu 
    50                  55                  60                  


Gln Lys Gln Ser Arg Ala Trp Gly Pro Thr Ser Gln Asp Thr Ile Arg 
65                  70                  75                  80  


Asn Gln Val Arg Lys Glu Leu Gln Ala Glu Ala Thr Val Ser Gly Ser 
                85                  90                  95      


Pro Glu Ala Pro Gly Thr Asn Val Val Ser Glu Pro Arg Glu Glu Gly 
            100                 105                 110         


Ser Ala His Leu Ala Val Pro Gly Val Tyr Phe Thr Cys Pro Leu Thr 
        115                 120                 125             


Gly Ala Thr Leu Arg Lys Asp Gln Arg Asp Ala Cys Ile Lys Glu Ala 
    130                 135                 140                 


Ile Leu Leu His Phe Ser Thr Asp Pro Val Ala Ala Ser Ile Met Lys 
145                 150                 155                 160 


Ile Tyr Thr Phe Asn Lys Asp Gln Asp Arg Val Lys Leu Gly Val Asp 
                165                 170                 175     


Thr Ile Ala Lys Tyr Leu Asp Asn Ile His Leu His Pro Glu Glu Glu 
            180                 185                 190         


Lys Tyr Arg Lys Ile Lys Leu Gln Asn Lys Val Phe Gln Glu Arg Ile 
        195                 200                 205             


Asn Cys Leu Glu Gly Thr His Glu Phe Phe Glu Ala Ile Gly Phe Gln 
    210                 215                 220                 


Lys Val Leu Leu Pro Ala Gln Asp Gln Glu Asp Pro Glu Glu Phe Tyr 
225                 230                 235                 240 


Val Leu Ser Glu Thr Thr Leu Ala Gln Pro Gln Ser Leu Glu Arg His 
                245                 250                 255     


Lys Glu Gln Leu Leu Ala Ala Glu Pro Val Arg Ala Lys Leu Asp Arg 
            260                 265                 270         


Gln Arg Arg Val Phe Gln Pro Ser Pro Leu Ala Ser Gln Phe Glu Leu 
        275                 280                 285             


Pro Gly Asp Phe Phe Asn Leu Thr Ala Glu Glu Ile Lys Arg Glu Gln 
    290                 295                 300                 


Arg Leu Arg Ser Glu Ala Val Glu Arg Leu Ser Val Leu Arg Thr Lys 
305                 310                 315                 320 


Ala Met Arg Glu Lys Glu Glu Gln Arg Gly Leu Arg Lys Tyr Asn Tyr 
                325                 330                 335     


Thr Leu Leu Arg Val Arg Leu Pro Asp Gly Cys Leu Leu Gln Gly Thr 
            340                 345                 350         


Phe Tyr Ala Arg Glu Arg Leu Gly Ala Val Tyr Gly Phe Val Arg Glu 
        355                 360                 365             


Ala Leu Gln Ser Asp Trp Leu Pro Phe Glu Leu Leu Ala Ser Gly Gly 
    370                 375                 380                 


Gln Lys Leu Ser Glu Asp Glu Asn Leu Ala Leu Asn Glu Cys Gly Leu 
385                 390                 395                 400 


Val Pro Ser Ala Leu Leu Thr Phe Ser Trp Asp Met Ala Val Leu Glu 
                405                 410                 415     


Asp Ile Lys Ala Ala Gly Ala Glu Pro Asp Ser Ile Leu Lys Pro Glu 
            420                 425                 430         


Leu Leu Ser Ala Ile Glu Lys Leu Leu 
        435                 440     


<210>  335
<211>  661
<212>  PRT
<213>  Homo sapiens

<400>  335

Met Glu Gly Ala Ala Ala Pro Val Ala Gly Asp Arg Pro Asp Leu Gly 
1               5                   10                  15      


Leu Gly Ala Pro Gly Ser Pro Arg Glu Ala Val Ala Gly Ala Thr Ala 
            20                  25                  30          


Ala Leu Glu Pro Arg Lys Pro His Gly Val Lys Arg His His His Lys 
        35                  40                  45              


His Asn Leu Lys His Arg Tyr Glu Leu Gln Glu Thr Leu Gly Lys Gly 
    50                  55                  60                  


Thr Tyr Gly Lys Val Lys Arg Ala Thr Glu Arg Phe Ser Gly Arg Val 
65                  70                  75                  80  


Val Ala Ile Lys Ser Ile Arg Lys Asp Lys Ile Lys Asp Glu Gln Asp 
                85                  90                  95      


Met Val His Ile Arg Arg Glu Ile Glu Ile Met Ser Ser Leu Asn His 
            100                 105                 110         


Pro His Ile Ile Ser Ile Tyr Glu Val Phe Glu Asn Lys Asp Lys Ile 
        115                 120                 125             


Val Ile Ile Met Glu Tyr Ala Ser Lys Gly Glu Leu Tyr Asp Tyr Ile 
    130                 135                 140                 


Ser Glu Arg Arg Arg Leu Ser Glu Arg Glu Thr Arg His Phe Phe Arg 
145                 150                 155                 160 


Gln Ile Val Ser Ala Val His Tyr Cys His Lys Asn Gly Val Val His 
                165                 170                 175     


Arg Asp Leu Lys Leu Glu Asn Ile Leu Leu Asp Asp Asn Cys Asn Ile 
            180                 185                 190         


Lys Ile Ala Asp Phe Gly Leu Ser Asn Leu Tyr Gln Lys Asp Lys Phe 
        195                 200                 205             


Leu Gln Thr Phe Cys Gly Ser Pro Leu Tyr Ala Ser Pro Glu Ile Val 
    210                 215                 220                 


Asn Gly Arg Pro Tyr Arg Gly Pro Glu Val Asp Ser Trp Ala Leu Gly 
225                 230                 235                 240 


Val Leu Leu Tyr Thr Leu Val Tyr Gly Thr Met Pro Phe Asp Gly Phe 
                245                 250                 255     


Asp His Lys Asn Leu Ile Arg Gln Ile Ser Ser Gly Glu Tyr Arg Glu 
            260                 265                 270         


Pro Thr Gln Pro Ser Asp Ala Arg Gly Leu Ile Arg Trp Met Leu Met 
        275                 280                 285             


Val Asn Pro Asp Arg Arg Ala Thr Ile Glu Asp Ile Ala Asn His Trp 
    290                 295                 300                 


Trp Val Asn Trp Gly Tyr Lys Ser Ser Val Cys Asp Cys Asp Ala Leu 
305                 310                 315                 320 


His Asp Ser Glu Ser Pro Leu Leu Ala Arg Ile Ile Asp Trp His His 
                325                 330                 335     


Arg Ser Thr Gly Leu Gln Ala Asp Thr Glu Ala Lys Met Lys Gly Leu 
            340                 345                 350         


Ala Lys Pro Thr Thr Ser Glu Val Met Leu Glu Arg Gln Arg Ser Leu 
        355                 360                 365             


Lys Lys Ser Lys Lys Glu Asn Asp Phe Ala Gln Ser Gly Gln Asp Ala 
    370                 375                 380                 


Val Pro Glu Ser Pro Ser Lys Leu Ser Ser Lys Arg Pro Lys Gly Ile 
385                 390                 395                 400 


Leu Lys Lys Arg Ser Asn Ser Glu His Arg Ser His Ser Thr Gly Phe 
                405                 410                 415     


Ile Glu Gly Val Val Gly Pro Ala Leu Pro Ser Thr Phe Lys Met Glu 
            420                 425                 430         


Gln Asp Leu Cys Arg Thr Gly Val Leu Leu Pro Ser Ser Pro Glu Ala 
        435                 440                 445             


Glu Val Pro Gly Lys Leu Ser Pro Lys Gln Ser Ala Thr Met Pro Lys 
    450                 455                 460                 


Lys Gly Ile Leu Lys Lys Thr Gln Gln Arg Glu Ser Gly Tyr Tyr Ser 
465                 470                 475                 480 


Ser Pro Glu Arg Ser Glu Ser Ser Glu Leu Leu Asp Ser Asn Asp Val 
                485                 490                 495     


Met Gly Ser Ser Ile Pro Ser Pro Ser Pro Pro Asp Pro Ala Arg Val 
            500                 505                 510         


Thr Ser His Ser Leu Ser Cys Arg Arg Lys Gly Ile Leu Lys His Ser 
        515                 520                 525             


Ser Lys Tyr Ser Ala Gly Thr Met Asp Pro Ala Leu Val Ser Pro Glu 
    530                 535                 540                 


Met Pro Thr Leu Glu Ser Leu Ser Glu Pro Gly Val Pro Ala Glu Gly 
545                 550                 555                 560 


Leu Ser Arg Ser Tyr Ser Arg Pro Ser Ser Val Ile Ser Asp Asp Ser 
                565                 570                 575     


Val Leu Ser Ser Asp Ser Phe Asp Leu Leu Asp Leu Gln Glu Asn Arg 
            580                 585                 590         


Pro Ala Arg Gln Arg Ile Arg Ser Cys Val Ser Ala Glu Asn Phe Leu 
        595                 600                 605             


Gln Ile Gln Asp Phe Glu Gly Leu Gln Asn Arg Pro Arg Pro Gln Tyr 
    610                 615                 620                 


Leu Lys Arg Tyr Arg Asn Arg Leu Ala Asp Ser Ser Phe Ser Leu Leu 
625                 630                 635                 640 


Thr Asp Met Asp Asp Val Thr Gln Val Tyr Lys Gln Ala Leu Glu Ile 
                645                 650                 655     


Cys Ser Lys Leu Asn 
            660     


<210>  336
<211>  423
<212>  PRT
<213>  Homo sapiens

<400>  336

Met Leu Pro Pro Gln Lys Lys Pro Trp Glu Ser Met Ala Lys Gly Leu 
1               5                   10                  15      


Val Leu Gly Ala Leu Phe Thr Ser Phe Leu Leu Leu Val Tyr Ser Tyr 
            20                  25                  30          


Ala Val Pro Pro Leu His Ala Gly Leu Ala Ser Thr Thr Pro Glu Ala 
        35                  40                  45              


Ala Ala Ser Cys Ser Pro Pro Ala Leu Glu Pro Glu Ala Val Ile Arg 
    50                  55                  60                  


Ala Asn Gly Ser Ala Gly Glu Cys Gln Pro Arg Arg Asn Ile Val Phe 
65                  70                  75                  80  


Leu Lys Thr His Lys Thr Ala Ser Ser Thr Leu Leu Asn Ile Leu Phe 
                85                  90                  95      


Arg Phe Gly Gln Lys His Arg Leu Lys Phe Ala Phe Pro Asn Gly Arg 
            100                 105                 110         


Asn Asp Phe Asp Tyr Pro Thr Phe Phe Ala Arg Ser Leu Val Gln Asp 
        115                 120                 125             


Tyr Arg Pro Gly Ala Cys Phe Asn Ile Ile Cys Asn His Met Arg Phe 
    130                 135                 140                 


His Tyr Asp Glu Val Arg Gly Leu Val Pro Thr Asn Ala Ile Phe Ile 
145                 150                 155                 160 


Thr Val Leu Arg Asp Pro Ala Arg Leu Phe Glu Ser Ser Phe His Tyr 
                165                 170                 175     


Phe Gly Pro Val Val Pro Leu Thr Trp Lys Leu Ser Ala Gly Asp Lys 
            180                 185                 190         


Leu Thr Glu Phe Leu Gln Asp Pro Asp Arg Tyr Tyr Asp Pro Asn Gly 
        195                 200                 205             


Phe Asn Ala His Tyr Leu Arg Asn Leu Leu Phe Phe Asp Leu Gly Tyr 
    210                 215                 220                 


Asp Asn Ser Leu Asp Pro Ser Ser Pro Gln Val Gln Glu His Ile Leu 
225                 230                 235                 240 


Glu Val Glu Arg Arg Phe His Leu Val Leu Leu Gln Glu Tyr Phe Asp 
                245                 250                 255     


Glu Ser Leu Val Leu Leu Lys Asp Leu Leu Cys Trp Glu Leu Glu Asp 
            260                 265                 270         


Val Leu Tyr Phe Lys Leu Asn Ala Arg Arg Asp Ser Pro Val Pro Arg 
        275                 280                 285             


Leu Ser Gly Glu Leu Tyr Gly Arg Ala Thr Ala Trp Asn Met Leu Asp 
    290                 295                 300                 


Ser His Leu Tyr Arg His Phe Asn Ala Ser Phe Trp Arg Lys Val Glu 
305                 310                 315                 320 


Ala Phe Gly Arg Glu Arg Met Ala Arg Glu Val Ala Ala Leu Arg His 
                325                 330                 335     


Ala Asn Glu Arg Met Arg Thr Ile Cys Ile Asp Gly Gly His Ala Val 
            340                 345                 350         


Asp Ala Ala Ala Ile Gln Asp Glu Ala Met Gln Pro Trp Gln Pro Leu 
        355                 360                 365             


Gly Thr Lys Ser Ile Leu Gly Tyr Asn Leu Lys Lys Ser Ile Gly Gln 
    370                 375                 380                 


Arg His Ala Gln Leu Cys Arg Arg Met Leu Thr Pro Glu Ile Gln Tyr 
385                 390                 395                 400 


Leu Met Asp Leu Gly Ala Asn Leu Trp Val Thr Lys Leu Trp Lys Phe 
                405                 410                 415     


Ile Arg Asp Phe Leu Arg Trp 
            420             


<210>  337
<211>  277
<212>  PRT
<213>  Homo sapiens

<400>  337

Met Val Arg Leu Pro Leu Gln Cys Val Leu Trp Gly Cys Leu Leu Thr 
1               5                   10                  15      


Ala Val His Pro Glu Pro Pro Thr Ala Cys Arg Glu Lys Gln Tyr Leu 
            20                  25                  30          


Ile Asn Ser Gln Cys Cys Ser Leu Cys Gln Pro Gly Gln Lys Leu Val 
        35                  40                  45              


Ser Asp Cys Thr Glu Phe Thr Glu Thr Glu Cys Leu Pro Cys Gly Glu 
    50                  55                  60                  


Ser Glu Phe Leu Asp Thr Trp Asn Arg Glu Thr His Cys His Gln His 
65                  70                  75                  80  


Lys Tyr Cys Asp Pro Asn Leu Gly Leu Arg Val Gln Gln Lys Gly Thr 
                85                  90                  95      


Ser Glu Thr Asp Thr Ile Cys Thr Cys Glu Glu Gly Trp His Cys Thr 
            100                 105                 110         


Ser Glu Ala Cys Glu Ser Cys Val Leu His Arg Ser Cys Ser Pro Gly 
        115                 120                 125             


Phe Gly Val Lys Gln Ile Ala Thr Gly Val Ser Asp Thr Ile Cys Glu 
    130                 135                 140                 


Pro Cys Pro Val Gly Phe Phe Ser Asn Val Ser Ser Ala Phe Glu Lys 
145                 150                 155                 160 


Cys His Pro Trp Thr Ser Cys Glu Thr Lys Asp Leu Val Val Gln Gln 
                165                 170                 175     


Ala Gly Thr Asn Lys Thr Asp Val Val Cys Gly Pro Gln Asp Arg Leu 
            180                 185                 190         


Arg Ala Leu Val Val Ile Pro Ile Ile Phe Gly Ile Leu Phe Ala Ile 
        195                 200                 205             


Leu Leu Val Leu Val Phe Ile Lys Lys Val Ala Lys Lys Pro Thr Asn 
    210                 215                 220                 


Lys Ala Pro His Pro Lys Gln Glu Pro Gln Glu Ile Asn Phe Pro Asp 
225                 230                 235                 240 


Asp Leu Pro Gly Ser Asn Thr Ala Ala Pro Val Gln Glu Thr Leu His 
                245                 250                 255     


Gly Cys Gln Pro Val Thr Gln Glu Asp Gly Lys Glu Ser Arg Ile Ser 
            260                 265                 270         


Val Gln Glu Arg Gln 
        275         


<210>  338
<211>  148
<212>  PRT
<213>  Homo sapiens

<400>  338

Met Thr Lys Ala Leu Leu Ile Tyr Leu Val Ser Ser Phe Leu Ala Leu 
1               5                   10                  15      


Asn Gln Ala Ser Leu Ile Ser Arg Cys Asp Leu Ala Gln Val Leu Gln 
            20                  25                  30          


Leu Glu Asp Leu Asp Gly Phe Glu Gly Tyr Ser Leu Ser Asp Trp Leu 
        35                  40                  45              


Cys Leu Ala Phe Val Glu Ser Lys Phe Asn Ile Ser Lys Ile Asn Glu 
    50                  55                  60                  


Asn Ala Asp Gly Ser Phe Asp Tyr Gly Leu Phe Gln Ile Asn Ser His 
65                  70                  75                  80  


Tyr Trp Cys Asn Asp Tyr Lys Ser Tyr Ser Glu Asn Leu Cys His Val 
                85                  90                  95      


Asp Cys Gln Asp Leu Leu Asn Pro Asn Leu Leu Ala Gly Ile His Cys 
            100                 105                 110         


Ala Lys Arg Ile Val Ser Gly Ala Arg Gly Met Asn Asn Trp Val Glu 
        115                 120                 125             


Trp Arg Leu His Cys Ser Gly Arg Pro Leu Phe Tyr Trp Leu Thr Gly 
    130                 135                 140                 


Cys Arg Leu Arg 
145             


<210>  339
<211>  95
<212>  PRT
<213>  Homo sapiens

<400>  339

Met Ser His Ser Tyr Lys Lys Ala Ile Ser Asp Glu Ala Leu Arg Pro 
1               5                   10                  15      


Phe Gln Met Asp Tyr Phe Gly Gly Leu Pro Pro Gly Gln Tyr Ala Thr 
            20                  25                  30          


Arg Met Thr Gly Gln Val His Gly Ser Gly Cys His Leu Arg Ser Ala 
        35                  40                  45              


Pro Cys Asp Leu Gly Ala Ser Gln Arg Lys Leu Ser Ser Asn Phe Ser 
    50                  55                  60                  


Glu Ile Asp Ala Gly Leu Phe Ser Gln Gly Lys Ser Ala Ala Tyr Thr 
65                  70                  75                  80  


Asp Ile Gly Ala Thr Lys Pro Val Glu Gln Arg Glu Thr Ala Ser 
                85                  90                  95  


<210>  340
<211>  729
<212>  PRT
<213>  Homo sapiens

<400>  340

Met Asn Lys Gly Trp Leu Glu Leu Glu Ser Asp Pro Gly Leu Phe Thr 
1               5                   10                  15      


Leu Leu Val Glu Asp Phe Gly Val Lys Gly Val Gln Val Glu Glu Ile 
            20                  25                  30          


Tyr Asp Leu Gln Ser Lys Cys Gln Gly Pro Val Tyr Gly Phe Ile Phe 
        35                  40                  45              


Leu Phe Lys Trp Ile Glu Glu Arg Arg Ser Arg Arg Lys Val Ser Thr 
    50                  55                  60                  


Leu Val Asp Asp Thr Ser Val Ile Asp Asp Asp Ile Val Asn Asn Met 
65                  70                  75                  80  


Phe Phe Ala His Gln Leu Ile Pro Asn Ser Cys Ala Thr His Ala Leu 
                85                  90                  95      


Leu Ser Val Leu Leu Asn Cys Ser Ser Val Asp Leu Gly Pro Thr Leu 
            100                 105                 110         


Ser Arg Met Lys Asp Phe Thr Lys Gly Phe Ser Pro Glu Ser Lys Gly 
        115                 120                 125             


Tyr Ala Ile Gly Asn Ala Pro Glu Leu Ala Lys Ala His Asn Ser His 
    130                 135                 140                 


Ala Arg Pro Glu Pro Arg His Leu Pro Glu Lys Gln Asn Gly Leu Ser 
145                 150                 155                 160 


Ala Val Arg Thr Met Glu Ala Phe His Phe Val Ser Tyr Val Pro Ile 
                165                 170                 175     


Thr Gly Arg Leu Phe Glu Leu Asp Gly Leu Lys Val Tyr Pro Ile Asp 
            180                 185                 190         


His Gly Pro Trp Gly Glu Asp Glu Glu Trp Thr Asp Lys Ala Arg Arg 
        195                 200                 205             


Val Ile Met Glu Arg Ile Gly Leu Ala Thr Ala Gly Glu Pro Tyr His 
    210                 215                 220                 


Asp Ile Arg Phe Asn Leu Met Ala Val Val Pro Asp Arg Arg Ile Lys 
225                 230                 235                 240 


Tyr Glu Ala Arg Leu His Val Leu Lys Val Asn Arg Gln Thr Val Leu 
                245                 250                 255     


Glu Ala Leu Gln Gln Leu Ile Arg Val Thr Gln Pro Glu Leu Ile Gln 
            260                 265                 270         


Thr His Lys Ser Gln Glu Ser Gln Leu Pro Glu Glu Ser Lys Ser Ala 
        275                 280                 285             


Ser Asn Lys Ser Pro Leu Val Leu Glu Ala Asn Arg Ala Pro Ala Ala 
    290                 295                 300                 


Ser Glu Gly Asn His Thr Asp Gly Ala Glu Glu Ala Ala Gly Ser Cys 
305                 310                 315                 320 


Ala Gln Ala Pro Ser His Ser Pro Pro Asn Lys Pro Lys Leu Val Val 
                325                 330                 335     


Lys Pro Pro Gly Ser Ser Leu Asn Gly Val His Pro Asn Pro Thr Pro 
            340                 345                 350         


Ile Val Gln Arg Leu Pro Ala Phe Leu Asp Asn His Asn Tyr Ala Lys 
        355                 360                 365             


Ser Pro Met Gln Glu Glu Glu Asp Leu Ala Ala Gly Val Gly Arg Ser 
    370                 375                 380                 


Arg Val Pro Val Arg Pro Pro Gln Gln Tyr Ser Asp Asp Glu Asp Asp 
385                 390                 395                 400 


Tyr Glu Asp Asp Glu Glu Asp Asp Val Gln Asn Thr Asn Ser Ala Leu 
                405                 410                 415     


Arg Tyr Lys Gly Lys Gly Thr Gly Lys Pro Gly Ala Leu Ser Gly Ser 
            420                 425                 430         


Ala Asp Gly Gln Leu Ser Val Leu Gln Pro Asn Thr Ile Asn Val Leu 
        435                 440                 445             


Ala Glu Lys Leu Lys Glu Ser Gln Lys Asp Leu Ser Ile Pro Leu Ser 
    450                 455                 460                 


Ile Lys Thr Ser Ser Gly Ala Gly Ser Pro Ala Val Ala Val Pro Thr 
465                 470                 475                 480 


His Ser Gln Pro Ser Pro Thr Pro Ser Asn Glu Ser Thr Asp Thr Ala 
                485                 490                 495     


Ser Glu Ile Gly Ser Ala Phe Asn Ser Pro Leu Arg Ser Pro Ile Arg 
            500                 505                 510         


Ser Ala Asn Pro Thr Arg Pro Ser Ser Pro Val Thr Ser His Ile Ser 
        515                 520                 525             


Lys Val Leu Phe Gly Glu Asp Asp Ser Leu Leu Arg Val Asp Cys Ile 
    530                 535                 540                 


Arg Tyr Asn Arg Ala Val Arg Asp Leu Gly Pro Val Ile Ser Thr Gly 
545                 550                 555                 560 


Leu Leu His Leu Ala Glu Asp Gly Val Leu Ser Pro Leu Ala Leu Thr 
                565                 570                 575     


Glu Gly Gly Lys Gly Ser Ser Pro Ser Ile Arg Pro Ile Gln Gly Ser 
            580                 585                 590         


Gln Gly Ser Ser Ser Pro Val Glu Lys Glu Val Val Glu Ala Thr Asp 
        595                 600                 605             


Ser Arg Glu Lys Thr Gly Met Val Arg Pro Gly Glu Pro Leu Ser Gly 
    610                 615                 620                 


Glu Lys Tyr Ser Pro Lys Glu Leu Leu Ala Leu Leu Lys Cys Val Glu 
625                 630                 635                 640 


Ala Glu Ile Ala Asn Tyr Glu Ala Cys Leu Lys Glu Glu Val Glu Lys 
                645                 650                 655     


Arg Lys Lys Phe Lys Ile Asp Asp Gln Arg Arg Thr His Asn Tyr Asp 
            660                 665                 670         


Glu Phe Ile Cys Thr Phe Ile Ser Met Leu Ala Gln Glu Gly Met Leu 
        675                 680                 685             


Ala Asn Leu Val Glu Gln Asn Ile Ser Val Arg Arg Arg Gln Gly Val 
    690                 695                 700                 


Ser Ile Gly Arg Leu His Lys Gln Arg Lys Pro Asp Arg Arg Lys Arg 
705                 710                 715                 720 


Ser Arg Pro Tyr Lys Ala Lys Arg Gln 
                725                 


<210>  341
<211>  625
<212>  PRT
<213>  Homo sapiens

<400>  341

Met Ser Gln Glu Ser Asp Asn Asn Lys Arg Leu Val Ala Leu Val Pro 
1               5                   10                  15      


Met Pro Ser Asp Pro Pro Phe Asn Thr Arg Arg Ala Tyr Thr Ser Glu 
            20                  25                  30          


Asp Glu Ala Trp Lys Ser Tyr Leu Glu Asn Pro Leu Thr Ala Ala Thr 
        35                  40                  45              


Lys Ala Met Met Ser Ile Asn Gly Asp Glu Asp Ser Ala Ala Ala Leu 
    50                  55                  60                  


Gly Leu Leu Tyr Asp Tyr Tyr Lys Val Pro Arg Asp Lys Arg Leu Leu 
65                  70                  75                  80  


Ser Val Ser Lys Ala Ser Asp Ser Gln Glu Asp Gln Glu Lys Arg Asn 
                85                  90                  95      


Cys Leu Gly Thr Ser Glu Ala Gln Ser Asn Leu Ser Gly Gly Glu Asn 
            100                 105                 110         


Arg Val Gln Val Leu Lys Thr Val Pro Val Asn Leu Ser Leu Asn Gln 
        115                 120                 125             


Asp His Leu Glu Asn Ser Lys Arg Glu Gln Tyr Ser Ile Ser Phe Pro 
    130                 135                 140                 


Glu Ser Ser Ala Ile Ile Pro Val Ser Gly Ile Thr Val Val Lys Ala 
145                 150                 155                 160 


Glu Asp Phe Thr Pro Val Phe Met Ala Pro Pro Val His Tyr Pro Arg 
                165                 170                 175     


Gly Asp Gly Glu Glu Gln Arg Val Val Ile Phe Glu Gln Thr Gln Tyr 
            180                 185                 190         


Asp Val Pro Ser Leu Ala Thr His Ser Ala Tyr Leu Lys Asp Asp Gln 
        195                 200                 205             


Arg Ser Thr Pro Asp Ser Thr Tyr Ser Glu Ser Phe Lys Asp Ala Ala 
    210                 215                 220                 


Thr Glu Lys Phe Arg Ser Ala Ser Val Gly Ala Glu Glu Tyr Met Tyr 
225                 230                 235                 240 


Asp Gln Thr Ser Ser Gly Thr Phe Gln Tyr Thr Leu Glu Ala Thr Lys 
                245                 250                 255     


Ser Leu Arg Gln Lys Gln Gly Glu Gly Pro Met Thr Tyr Leu Asn Lys 
            260                 265                 270         


Gly Gln Phe Tyr Ala Ile Thr Leu Ser Glu Thr Gly Asp Asn Lys Cys 
        275                 280                 285             


Phe Arg His Pro Ile Ser Lys Val Arg Ser Val Val Met Val Val Phe 
    290                 295                 300                 


Ser Glu Asp Lys Asn Arg Asp Glu Gln Leu Lys Tyr Trp Lys Tyr Trp 
305                 310                 315                 320 


His Ser Arg Gln His Thr Ala Lys Gln Arg Val Leu Asp Ile Ala Asp 
                325                 330                 335     


Tyr Lys Glu Ser Phe Asn Thr Ile Gly Asn Ile Glu Glu Ile Ala Tyr 
            340                 345                 350         


Asn Ala Val Ser Phe Thr Trp Asp Val Asn Glu Glu Ala Lys Ile Phe 
        355                 360                 365             


Ile Thr Val Asn Cys Leu Ser Thr Asp Phe Ser Ser Gln Lys Gly Val 
    370                 375                 380                 


Lys Gly Leu Pro Leu Met Ile Gln Ile Asp Thr Tyr Ser Tyr Asn Asn 
385                 390                 395                 400 


Arg Ser Asn Lys Pro Ile His Arg Ala Tyr Cys Gln Ile Lys Val Phe 
                405                 410                 415     


Cys Asp Lys Gly Ala Glu Arg Lys Ile Arg Asp Glu Glu Arg Lys Gln 
            420                 425                 430         


Asn Arg Lys Lys Gly Lys Gly Gln Ala Ser Gln Thr Gln Cys Asn Ser 
        435                 440                 445             


Ser Ser Asp Gly Lys Leu Ala Ala Ile Pro Leu Gln Lys Lys Ser Asp 
    450                 455                 460                 


Ile Thr Tyr Phe Lys Thr Met Pro Asp Leu His Ser Gln Pro Val Leu 
465                 470                 475                 480 


Phe Ile Pro Asp Val His Phe Ala Asn Leu Gln Arg Thr Gly Gln Val 
                485                 490                 495     


Tyr Tyr Asn Thr Asp Asp Glu Arg Glu Gly Gly Ser Val Leu Val Lys 
            500                 505                 510         


Arg Met Phe Arg Pro Met Glu Glu Glu Phe Gly Pro Val Pro Ser Lys 
        515                 520                 525             


Gln Met Lys Glu Glu Gly Thr Lys Arg Val Leu Leu Tyr Val Arg Lys 
    530                 535                 540                 


Glu Thr Asp Asp Val Phe Asp Ala Leu Met Leu Lys Ser Pro Thr Val 
545                 550                 555                 560 


Lys Gly Leu Met Glu Ala Ile Ser Glu Lys Tyr Gly Leu Pro Val Glu 
                565                 570                 575     


Lys Ile Ala Lys Leu Tyr Lys Lys Ser Lys Lys Gly Ile Leu Val Asn 
            580                 585                 590         


Met Asp Asp Asn Ile Ile Glu His Tyr Ser Asn Glu Asp Thr Phe Ile 
        595                 600                 605             


Leu Asn Met Glu Ser Met Val Glu Gly Phe Lys Val Thr Leu Met Glu 
    610                 615                 620                 


Ile 
625 


<210>  342
<211>  134
<212>  PRT
<213>  Homo sapiens

<400>  342

Met Ala Ala Thr Met Lys Lys Ala Ala Ala Glu Asp Val Asn Val Thr 
1               5                   10                  15      


Phe Glu Asp Gln Gln Lys Ile Asn Lys Phe Ala Arg Asn Thr Ser Arg 
            20                  25                  30          


Ile Thr Glu Leu Lys Glu Glu Ile Glu Val Lys Lys Lys Gln Leu Gln 
        35                  40                  45              


Asn Leu Glu Asp Ala Cys Asp Asp Ile Met Leu Ala Asp Asp Asp Cys 
    50                  55                  60                  


Leu Met Ile Pro Tyr Gln Ile Gly Asp Val Phe Ile Ser His Ser Gln 
65                  70                  75                  80  


Glu Glu Thr Gln Glu Met Leu Glu Glu Ala Lys Lys Asn Leu Gln Glu 
                85                  90                  95      


Glu Ile Asp Ala Leu Glu Ser Arg Val Glu Ser Ile Gln Arg Val Leu 
            100                 105                 110         


Ala Asp Leu Lys Val Gln Leu Tyr Ala Lys Phe Gly Ser Asn Ile Asn 
        115                 120                 125             


Leu Glu Ala Asp Glu Ser 
    130                 


<210>  343
<211>  561
<212>  PRT
<213>  Homo sapiens

<400>  343

Met Glu Pro Leu Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Lys 
1               5                   10                  15      


Gln Pro His Leu Ala Pro Leu Gln Met Asp Ala Arg Glu Lys Gln Gly 
            20                  25                  30          


Gln Gln Met Arg Glu Ala Gln Phe Leu Tyr Ala Gln Lys Leu Val Thr 
        35                  40                  45              


Gln Pro Thr Leu Leu Ser Ala Thr Ala Gly Arg Pro Ser Gly Ser Thr 
    50                  55                  60                  


Pro Leu Gly Pro Leu Ala Arg Val Pro Pro Thr Ala Ala Val Ala Gln 
65                  70                  75                  80  


Val Phe Glu Arg Gly Asn Met Asn Ser Glu Pro Glu Glu Glu Asp Gly 
                85                  90                  95      


Gly Leu Glu Asp Glu Asp Gly Asp Asp Glu Val Ala Glu Val Ala Glu 
            100                 105                 110         


Lys Glu Thr Gln Ala Ala Ser Lys Tyr Phe His Val Gln Lys Val Ala 
        115                 120                 125             


Arg Gln Asp Pro Arg Val Ala Pro Met Ser Asn Leu Leu Pro Ala Pro 
    130                 135                 140                 


Gly Leu Pro Pro His Gly Gln Gln Ala Lys Glu Asp His Thr Lys Asp 
145                 150                 155                 160 


Ala Ser Lys Ala Ser Pro Ser Val Ser Thr Ala Gly Gln Pro Asn Trp 
                165                 170                 175     


Asn Leu Asp Glu Gln Leu Lys Gln Asn Gly Gly Leu Ala Trp Ser Asp 
            180                 185                 190         


Asp Ala Asp Gly Gly Arg Gly Arg Glu Ile Ser Arg Asp Phe Ala Lys 
        195                 200                 205             


Leu Tyr Glu Leu Asp Gly Asp Pro Glu Arg Lys Glu Phe Leu Asp Asp 
    210                 215                 220                 


Leu Phe Val Phe Met Gln Lys Arg Gly Thr Pro Ile Asn Arg Ile Pro 
225                 230                 235                 240 


Ile Met Ala Lys Gln Ile Leu Asp Leu Tyr Met Leu Tyr Lys Leu Val 
                245                 250                 255     


Thr Glu Lys Gly Gly Leu Val Glu Ile Ile Asn Lys Lys Ile Trp Arg 
            260                 265                 270         


Glu Ile Thr Lys Gly Leu Asn Leu Pro Thr Ser Ile Thr Ser Ala Ala 
        275                 280                 285             


Phe Thr Leu Arg Thr Gln Tyr Met Lys Tyr Leu Tyr Ala Tyr Glu Cys 
    290                 295                 300                 


Glu Lys Lys Ala Leu Ser Ser Pro Ala Glu Leu Gln Ala Ala Ile Asp 
305                 310                 315                 320 


Gly Asn Arg Arg Glu Gly Arg Arg Pro Ser Tyr Ser Ser Ser Leu Phe 
                325                 330                 335     


Gly Tyr Ser Pro Ala Ala Ala Thr Ala Ala Ala Ala Ala Gly Ala Pro 
            340                 345                 350         


Ala Leu Leu Ser Pro Pro Lys Ile Arg Phe Pro Ile Leu Gly Leu Gly 
        355                 360                 365             


Ser Ser Ser Gly Thr Asn Thr Ser Ser Pro Arg Ile Ser Pro Ala Thr 
    370                 375                 380                 


Thr Leu Arg Lys Gly Asp Gly Ala Pro Val Thr Thr Val Pro Val Pro 
385                 390                 395                 400 


Asn Arg Leu Ala Val Pro Val Thr Leu Ala Ser Gln Gln Ala Gly Thr 
                405                 410                 415     


Arg Thr Ala Ala Leu Glu Gln Leu Arg Glu Arg Leu Glu Ser Gly Glu 
            420                 425                 430         


Pro Ala Glu Lys Lys Ala Ser Arg Leu Ser Glu Glu Glu Gln Arg Leu 
        435                 440                 445             


Val Gln Gln Ala Phe Gln Arg Asn Phe Phe Ser Met Ala Arg Gln Leu 
    450                 455                 460                 


Pro Met Lys Ile Arg Ile Asn Gly Arg Ala Glu Asp Arg Ala Glu Ala 
465                 470                 475                 480 


Ser Ala Ala Ala Leu Asn Leu Thr Thr Ser Ser Ile Gly Ser Ile Asn 
                485                 490                 495     


Met Ser Val Asp Ile Asp Gly Thr Thr Tyr Ala Gly Val Leu Phe Ala 
            500                 505                 510         


Gln Lys Pro Val Val His Leu Ile Thr Gly Ser Ala Pro Gln Ser Leu 
        515                 520                 525             


Gly Ser Ser Ala Ser Ser Ser Ser Ser Ser His Cys Ser Pro Ser Pro 
    530                 535                 540                 


Thr Ser Ser Arg Gly Thr Pro Ser Ala Glu Pro Ser Thr Ser Trp Ser 
545                 550                 555                 560 


Leu 
    


<210>  344
<211>  155
<212>  PRT
<213>  Homo sapiens

<400>  344

Met Gly Gly Asn Gly Ser Thr Cys Lys Pro Asp Thr Glu Arg Gln Gly 
1               5                   10                  15      


Thr Leu Ser Thr Ala Ala Pro Thr Thr Ser Pro Ala Pro Cys Leu Ser 
            20                  25                  30          


Asn His His Asn Lys Lys His Leu Ile Leu Ala Phe Cys Ala Gly Val 
        35                  40                  45              


Leu Leu Thr Leu Leu Leu Ile Ala Phe Ile Phe Leu Ile Ile Lys Ser 
    50                  55                  60                  


Tyr Arg Lys Tyr Arg Arg Glu Arg Leu Pro Ile Ser Pro Gly Pro Leu 
65                  70                  75                  80  


Leu Arg Trp Val Pro Leu Leu Ser Gly Thr Met Ala Asp His Ser Lys 
                85                  90                  95      


Pro Gln Ala Pro Asp Pro His Ser Asp Pro Pro Ala Lys Leu Ser Ser 
            100                 105                 110         


Ile Pro Gly Glu Ser Leu Thr Tyr Ala Ser Thr Thr Phe Lys Leu Ser 
        115                 120                 125             


Glu Glu Lys Ser Asn His Leu Ala Glu Asn His Ser Ala Asp Phe Asp 
    130                 135                 140                 


Pro Ile Val Tyr Ala Gln Ile Lys Val Thr Asn 
145                 150                 155 


<210>  345
<211>  531
<212>  PRT
<213>  Homo sapiens

<400>  345

Met Glu Leu Gln Ser Arg Pro Glu Ala Leu Ala Val Glu Leu Ala Arg 
1               5                   10                  15      


His Gln Asn Gly Asp Leu Lys Lys Gln Leu His Glu Arg Gln Pro Arg 
            20                  25                  30          


Ile Ala Ala Leu Ser Asp Lys Gln Ala Leu Gly Thr Ile Thr Ala Val 
        35                  40                  45              


Pro Val Thr Gly Pro Gln Val Ser Ser Leu Gln Arg Leu Ala Gly Gln 
    50                  55                  60                  


Gly Ala Ala Val Leu Pro Gln Val Arg Pro Lys Thr Leu Ile Pro Asp 
65                  70                  75                  80  


Ser Leu Pro Val Ala Pro Gly Arg Asp Arg Pro Pro Lys Gln Pro Pro 
                85                  90                  95      


Thr Phe Gln Lys Ala Thr Val Val Ser Val Lys Asn Pro Ser Pro Ala 
            100                 105                 110         


Leu Pro Thr Ala Asn Asn Thr Val Ser His Val Pro Ala Pro Gly Ser 
        115                 120                 125             


Gln Pro Gln Ala Leu Ala Glu Pro Ala Ala Leu Ala Ser Pro Leu Ser 
    130                 135                 140                 


Ser Ala Gly Val Ala Tyr Ala Ile Ile Ser Thr Ser Pro Ser Asn Ala 
145                 150                 155                 160 


Ala Ala Met Ala Pro Ser Thr Ala Val Ser Val Val Ser Asp Ser Ile 
                165                 170                 175     


Lys Val Gln Pro Leu Leu Ile Ser Ala Asp Asn Lys Pro Pro Pro Arg 
            180                 185                 190         


Leu Leu Ser Ser Pro His Pro Ala Thr His His Cys Pro Leu His Pro 
        195                 200                 205             


Ser Ser Leu Pro Leu Thr Pro Pro Ser Pro Ser Leu Ser Pro Ser Pro 
    210                 215                 220                 


Leu His Gly Ile Phe Gln Val Ile Ile Ile Gln Pro Gln Val Gln Thr 
225                 230                 235                 240 


Gln Pro Glu Ser Thr Ala Glu Ser Arg Pro Pro Thr Glu Glu Pro Ser 
                245                 250                 255     


Gln Gly Ala Gln Ala Thr Lys Lys Lys Lys Glu Asp Arg Pro Pro Thr 
            260                 265                 270         


Gln Glu Asn Pro Glu Lys Ile Ala Phe Met Val Ala Leu Gly Leu Val 
        275                 280                 285             


Thr Thr Glu His Leu Glu Glu Ile Gln Ser Lys Arg Gln Glu Arg Lys 
    290                 295                 300                 


Arg Arg Ser Thr Ala Asn Pro Ala Tyr Ser Gly Leu Leu Glu Thr Glu 
305                 310                 315                 320 


Arg Lys Arg Leu Ala Ser Asn Tyr Leu Asn Asn Pro Leu Phe Leu Thr 
                325                 330                 335     


Ala Arg Ala Asn Glu Asp Pro Cys Trp Lys Asn Glu Ile Thr His Asp 
            340                 345                 350         


Glu His Cys Ala Ala Cys Lys Arg Gly Ala Asn Leu Gln Pro Cys Gly 
        355                 360                 365             


Thr Cys Pro Gly Ala Tyr His Leu Ser Cys Leu Glu Pro Pro Leu Lys 
    370                 375                 380                 


Thr Ala Pro Lys Gly Val Trp Val Cys Pro Arg Cys Gln Gln Lys Ala 
385                 390                 395                 400 


Leu Lys Lys Asp Glu Gly Val Pro Trp Thr Gly Met Leu Ala Ile Val 
                405                 410                 415     


His Ser Tyr Val Thr His Lys Thr Val Lys Glu Glu Glu Lys Gln Lys 
            420                 425                 430         


Leu Leu Gln Arg Gly Ser Glu Leu Gln Asn Glu His Gln Gln Leu Glu 
        435                 440                 445             


Glu Arg Asp Arg Arg Leu Ala Ser Ala Val Gln Lys Cys Leu Glu Leu 
    450                 455                 460                 


Lys Thr Ser Leu Leu Ala Arg Gln Arg Gly Thr Gln Ser Ser Leu Asp 
465                 470                 475                 480 


Arg Leu Arg Ala Leu Leu Arg Leu Ile Gln Gly Glu Gln Leu Leu Gln 
                485                 490                 495     


Val Thr Met Thr Thr Thr Ser Pro Ala Pro Leu Leu Ala Gly Pro Trp 
            500                 505                 510         


Thr Lys Pro Ser Val Ala Ala Thr His Pro Thr Val Gln His Pro Gln 
        515                 520                 525             


Gly His Asn 
    530     


<210>  346
<211>  120
<212>  PRT
<213>  Homo sapiens

<400>  346

Met Trp Ala Ser Glu Leu Arg Gly Pro Gly Cys Ala Asp Ser Leu Asn 
1               5                   10                  15      


Ala Ala Leu Ala His Ser Pro Leu Arg Asn Arg Gln Cys Arg Gly Phe 
            20                  25                  30          


Pro Gly Gly Gly His Ser Ile Gln Pro Leu Tyr Thr Pro Arg Ala Pro 
        35                  40                  45              


Ala Ala Ala Pro Pro Pro Pro His Lys Met Ala Ala Pro Ile Glu Glu 
    50                  55                  60                  


Thr Ala Ala Ala Ser Pro Ala Pro Phe Cys Gly Arg Arg Glu Ile Cys 
65                  70                  75                  80  


Gln His Gly Lys Pro Leu Leu Arg Met His Pro Ser Leu Glu Thr Pro 
                85                  90                  95      


Leu Lys Gly Trp Ser Leu Gly Asp His Ile Lys Arg Lys Met Pro Thr 
            100                 105                 110         


Thr Ser Thr Thr Ser Thr Arg Phe 
        115                 120 


<210>  347
<211>  354
<212>  PRT
<213>  Homo sapiens

<400>  347

Met Cys Gly Arg Thr Ser Cys His Leu Pro Arg Asp Val Leu Thr Arg 
1               5                   10                  15      


Ala Cys Ala Tyr Gln Asp Arg Arg Gly Gln Gln Arg Leu Pro Glu Trp 
            20                  25                  30          


Arg Asp Pro Asp Lys Tyr Cys Pro Ser Tyr Asn Lys Ser Pro Gln Ser 
        35                  40                  45              


Asn Ser Pro Val Leu Leu Ser Arg Leu His Phe Asp Lys Asp Ala Asp 
    50                  55                  60                  


Ser Ser Glu Arg Ile Ile Ala Pro Met Arg Trp Gly Leu Val Pro Ser 
65                  70                  75                  80  


Trp Phe Lys Glu Ser Asp Pro Ser Lys Leu Gln Phe Asn Thr Thr Asn 
                85                  90                  95      


Cys Arg Ser Asp Thr Val Met Glu Lys Arg Ser Phe Lys Val Pro Leu 
            100                 105                 110         


Gly Lys Gly Arg Arg Cys Val Val Leu Ala Asp Gly Phe Tyr Glu Trp 
        115                 120                 125             


Gln Arg Cys Gln Gly Thr Asn Gln Arg Gln Pro Tyr Phe Ile Tyr Phe 
    130                 135                 140                 


Pro Gln Ile Lys Thr Glu Lys Ser Gly Ser Ile Gly Ala Ala Asp Ser 
145                 150                 155                 160 


Pro Glu Asn Trp Glu Lys Val Trp Asp Asn Trp Arg Leu Leu Thr Met 
                165                 170                 175     


Ala Gly Ile Phe Asp Cys Trp Glu Pro Pro Glu Gly Gly Asp Val Leu 
            180                 185                 190         


Tyr Ser Tyr Thr Ile Ile Thr Val Asp Ser Cys Lys Gly Leu Ser Asp 
        195                 200                 205             


Ile His His Arg Met Pro Ala Ile Leu Asp Gly Glu Glu Ala Val Ser 
    210                 215                 220                 


Lys Trp Leu Asp Phe Gly Glu Val Ser Thr Gln Glu Ala Leu Lys Leu 
225                 230                 235                 240 


Ile His Pro Thr Glu Asn Ile Thr Phe His Ala Val Ser Ser Val Val 
                245                 250                 255     


Asn Asn Ser Arg Asn Asn Thr Pro Glu Cys Leu Ala Pro Val Asp Leu 
            260                 265                 270         


Val Val Lys Lys Glu Leu Arg Ala Ser Gly Ser Ser Gln Arg Met Leu 
        275                 280                 285             


Gln Trp Leu Ala Thr Lys Ser Pro Lys Lys Glu Asp Ser Lys Thr Pro 
    290                 295                 300                 


Gln Lys Glu Glu Ser Asp Val Pro Gln Trp Ser Ser Gln Phe Leu Gln 
305                 310                 315                 320 


Lys Ser Pro Leu Pro Thr Lys Arg Gly Thr Ala Gly Leu Leu Glu Gln 
                325                 330                 335     


Trp Leu Lys Arg Glu Lys Glu Glu Glu Pro Val Ala Lys Arg Pro Tyr 
            340                 345                 350         


Ser Gln 
        


<210>  348
<211>  283
<212>  PRT
<213>  Homo sapiens

<400>  348

Met Pro His Arg Lys Glu Arg Pro Ser Gly Ser Ser Leu His Thr His 
1               5                   10                  15      


Gly Ser Thr Gly Thr Ala Glu Gly Gly Asn Met Ser Arg Leu Ser Leu 
            20                  25                  30          


Thr Arg Ser Pro Val Ser Pro Leu Ala Ala Gln Gly Ile Pro Leu Pro 
        35                  40                  45              


Ala Gln Leu Thr Lys Ser Asn Ala Pro Val His Ile Asp Val Gly Gly 
    50                  55                  60                  


His Met Tyr Thr Ser Ser Leu Ala Thr Leu Thr Lys Tyr Pro Asp Ser 
65                  70                  75                  80  


Arg Ile Ser Arg Leu Phe Asn Gly Thr Glu Pro Ile Val Leu Asp Ser 
                85                  90                  95      


Leu Lys Gln His Tyr Phe Ile Asp Arg Asp Gly Glu Ile Phe Arg Tyr 
            100                 105                 110         


Val Leu Ser Phe Leu Arg Thr Ser Lys Leu Leu Leu Pro Asp Asp Phe 
        115                 120                 125             


Lys Asp Phe Ser Leu Leu Tyr Glu Glu Ala Arg Tyr Tyr Gln Leu Gln 
    130                 135                 140                 


Pro Met Val Arg Glu Leu Glu Arg Trp Gln Gln Glu Gln Glu Gln Arg 
145                 150                 155                 160 


Arg Arg Ser Arg Ala Cys Asp Cys Leu Val Val Arg Val Thr Pro Asp 
                165                 170                 175     


Leu Gly Glu Arg Ile Ala Leu Ser Gly Glu Lys Ala Leu Ile Glu Glu 
            180                 185                 190         


Val Phe Pro Glu Thr Gly Asp Val Met Cys Asn Ser Val Asn Ala Gly 
        195                 200                 205             


Trp Asn Gln Asp Pro Thr His Val Ile Arg Phe Pro Leu Asn Gly Tyr 
    210                 215                 220                 


Cys Arg Leu Asn Ser Val Gln Val Leu Glu Arg Leu Phe Gln Arg Gly 
225                 230                 235                 240 


Phe Ser Val Ala Ala Ser Cys Gly Gly Gly Val Asp Ser Ser Gln Phe 
                245                 250                 255     


Ser Glu Tyr Val Leu Cys Arg Glu Glu Arg Arg Pro Gln Pro Thr Pro 
            260                 265                 270         


Thr Ala Val Arg Ile Lys Gln Glu Pro Leu Asp 
        275                 280             


<210>  349
<211>  180
<212>  PRT
<213>  Homo sapiens

<400>  349

Met Leu Cys Leu Leu Leu Thr Leu Gly Val Ala Leu Val Cys Gly Val 
1               5                   10                  15      


Pro Ala Met Asp Ile Pro Gln Thr Lys Gln Asp Leu Glu Leu Pro Lys 
            20                  25                  30          


Leu Ala Gly Thr Trp His Ser Met Ala Met Ala Thr Asn Asn Ile Ser 
        35                  40                  45              


Leu Met Ala Thr Leu Lys Ala Pro Leu Arg Val His Ile Thr Ser Leu 
    50                  55                  60                  


Leu Pro Thr Pro Glu Asp Asn Leu Glu Ile Val Leu His Arg Trp Glu 
65                  70                  75                  80  


Asn Asn Ser Cys Val Glu Lys Lys Val Leu Gly Glu Lys Thr Glu Asn 
                85                  90                  95      


Pro Lys Lys Phe Lys Ile Asn Tyr Thr Val Ala Asn Glu Ala Thr Leu 
            100                 105                 110         


Leu Asp Thr Asp Tyr Asp Asn Phe Leu Phe Leu Cys Leu Gln Asp Thr 
        115                 120                 125             


Thr Thr Pro Ile Gln Ser Met Met Cys Gln Tyr Leu Ala Arg Val Leu 
    130                 135                 140                 


Val Glu Asp Asp Glu Ile Met Gln Gly Phe Ile Arg Ala Phe Arg Pro 
145                 150                 155                 160 


Leu Pro Arg His Leu Trp Tyr Leu Leu Asp Leu Lys Gln Met Glu Glu 
                165                 170                 175     


Pro Cys Arg Phe 
            180 


<210>  350
<211>  407
<212>  PRT
<213>  Homo sapiens

<400>  350

Met Asn Asn Ser Gly Ala Asp Glu Ile Gly Lys Leu Phe Val Gly Gly 
1               5                   10                  15      


Leu Asp Trp Ser Thr Thr Gln Glu Thr Leu Arg Ser Tyr Phe Ser Gln 
            20                  25                  30          


Tyr Gly Glu Val Val Asp Cys Val Ile Met Lys Asp Lys Thr Thr Asn 
        35                  40                  45              


Gln Ser Arg Gly Phe Gly Phe Val Lys Phe Lys Asp Pro Asn Cys Val 
    50                  55                  60                  


Gly Thr Val Leu Ala Ser Arg Pro His Thr Leu Asp Gly Arg Asn Ile 
65                  70                  75                  80  


Asp Pro Lys Pro Cys Thr Pro Arg Gly Met Gln Pro Glu Arg Thr Arg 
                85                  90                  95      


Pro Lys Glu Gly Trp Gln Lys Gly Pro Arg Ser Asp Asn Ser Lys Ser 
            100                 105                 110         


Asn Lys Ile Phe Val Gly Gly Ile Pro His Asn Cys Gly Glu Thr Glu 
        115                 120                 125             


Leu Arg Glu Tyr Phe Lys Lys Phe Gly Val Val Thr Glu Val Val Met 
    130                 135                 140                 


Ile Tyr Asp Ala Glu Lys Gln Arg Pro Arg Gly Phe Gly Phe Ile Thr 
145                 150                 155                 160 


Phe Glu Asp Glu Gln Ser Val Asp Gln Ala Val Asn Met His Phe His 
                165                 170                 175     


Asp Ile Met Gly Lys Lys Val Glu Val Lys Arg Ala Glu Pro Arg Asp 
            180                 185                 190         


Ser Lys Ser Gln Ala Pro Gly Gln Pro Gly Ala Ser Gln Trp Gly Ser 
        195                 200                 205             


Arg Val Val Pro Asn Ala Ala Asn Gly Trp Ala Gly Gln Pro Pro Pro 
    210                 215                 220                 


Thr Trp Gln Gln Gly Tyr Gly Pro Gln Gly Met Trp Val Pro Ala Gly 
225                 230                 235                 240 


Gln Ala Ile Gly Gly Tyr Gly Pro Pro Pro Ala Gly Arg Gly Ala Pro 
                245                 250                 255     


Pro Pro Pro Pro Pro Phe Thr Ser Tyr Ile Val Ser Thr Pro Pro Gly 
            260                 265                 270         


Gly Phe Pro Pro Pro Gln Gly Phe Pro Gln Gly Tyr Gly Ala Pro Pro 
        275                 280                 285             


Gln Phe Ser Phe Gly Tyr Gly Pro Pro Pro Pro Pro Pro Asp Gln Phe 
    290                 295                 300                 


Ala Pro Pro Gly Val Pro Pro Pro Pro Ala Thr Pro Gly Ala Ala Pro 
305                 310                 315                 320 


Leu Ala Phe Pro Pro Pro Pro Ser Gln Ala Ala Pro Asp Met Ser Lys 
                325                 330                 335     


Pro Pro Thr Ala Gln Pro Asp Phe Pro Tyr Gly Gln Tyr Ala Gly Tyr 
            340                 345                 350         


Gly Gln Asp Leu Ser Gly Phe Gly Gln Gly Phe Ser Asp Pro Ser Gln 
        355                 360                 365             


Gln Pro Pro Ser Tyr Gly Gly Pro Ser Val Pro Gly Ser Gly Gly Pro 
    370                 375                 380                 


Pro Ala Gly Gly Ser Gly Phe Gly Arg Gly Gln Asn His Asn Val Gln 
385                 390                 395                 400 


Gly Phe His Pro Tyr Arg Arg 
                405         


<210>  351
<211>  318
<212>  PRT
<213>  Homo sapiens

<400>  351

Met Pro Asn Ile Lys Ile Phe Ser Gly Ser Ser His Gln Asp Leu Ser 
1               5                   10                  15      


Gln Lys Ile Ala Asp Arg Leu Gly Leu Glu Leu Gly Lys Val Val Thr 
            20                  25                  30          


Lys Lys Phe Ser Asn Gln Glu Thr Cys Val Glu Ile Gly Glu Ser Val 
        35                  40                  45              


Arg Gly Glu Asp Val Tyr Ile Val Gln Ser Gly Cys Gly Glu Ile Asn 
    50                  55                  60                  


Asp Asn Leu Met Glu Leu Leu Ile Met Ile Asn Ala Cys Lys Ile Ala 
65                  70                  75                  80  


Ser Ala Ser Arg Val Thr Ala Val Ile Pro Cys Phe Pro Tyr Ala Arg 
                85                  90                  95      


Gln Asp Lys Lys Asp Lys Ser Arg Ala Pro Ile Ser Ala Lys Leu Val 
            100                 105                 110         


Ala Asn Met Leu Ser Val Ala Gly Ala Asp His Ile Ile Thr Met Asp 
        115                 120                 125             


Leu His Ala Ser Gln Ile Gln Gly Phe Phe Asp Ile Pro Val Asp Asn 
    130                 135                 140                 


Leu Tyr Ala Glu Pro Ala Val Leu Lys Trp Ile Arg Glu Asn Ile Ser 
145                 150                 155                 160 


Glu Trp Arg Asn Cys Thr Ile Val Ser Pro Asp Ala Gly Gly Ala Lys 
                165                 170                 175     


Arg Val Thr Ser Ile Ala Asp Arg Leu Asn Val Asp Phe Ala Leu Ile 
            180                 185                 190         


His Lys Glu Arg Lys Lys Ala Asn Glu Val Asp Arg Met Val Leu Val 
        195                 200                 205             


Gly Asp Val Lys Asp Arg Val Ala Ile Leu Val Asp Asp Met Ala Asp 
    210                 215                 220                 


Thr Cys Gly Thr Ile Cys His Ala Ala Asp Lys Leu Leu Ser Ala Gly 
225                 230                 235                 240 


Ala Thr Arg Val Tyr Ala Ile Leu Thr His Gly Ile Phe Ser Gly Pro 
                245                 250                 255     


Ala Ile Ser Arg Ile Asn Asn Ala Cys Phe Glu Ala Val Val Val Thr 
            260                 265                 270         


Asn Thr Ile Pro Gln Glu Asp Lys Met Lys His Cys Ser Lys Ile Gln 
        275                 280                 285             


Val Ile Asp Ile Ser Met Ile Leu Ala Glu Ala Ile Arg Arg Thr His 
    290                 295                 300                 


Asn Gly Glu Ser Val Ser Tyr Leu Phe Ser His Val Pro Leu 
305                 310                 315             


<210>  352
<211>  972
<212>  PRT
<213>  Homo sapiens

<400>  352

Met Gly Pro Gly Val Leu Leu Leu Leu Leu Val Ala Thr Ala Trp His 
1               5                   10                  15      


Gly Gln Gly Ile Pro Val Ile Glu Pro Ser Val Pro Glu Leu Val Val 
            20                  25                  30          


Lys Pro Gly Ala Thr Val Thr Leu Arg Cys Val Gly Asn Gly Ser Val 
        35                  40                  45              


Glu Trp Asp Gly Pro Pro Ser Pro His Trp Thr Leu Tyr Ser Asp Gly 
    50                  55                  60                  


Ser Ser Ser Ile Leu Ser Thr Asn Asn Ala Thr Phe Gln Asn Thr Gly 
65                  70                  75                  80  


Thr Tyr Arg Cys Thr Glu Pro Gly Asp Pro Leu Gly Gly Ser Ala Ala 
                85                  90                  95      


Ile His Leu Tyr Val Lys Asp Pro Ala Arg Pro Trp Asn Val Leu Ala 
            100                 105                 110         


Gln Glu Val Val Val Phe Glu Asp Gln Asp Ala Leu Leu Pro Cys Leu 
        115                 120                 125             


Leu Thr Asp Pro Val Leu Glu Ala Gly Val Ser Leu Val Arg Val Arg 
    130                 135                 140                 


Gly Arg Pro Leu Met Arg His Thr Asn Tyr Ser Phe Ser Pro Trp His 
145                 150                 155                 160 


Gly Phe Thr Ile His Arg Ala Lys Phe Ile Gln Ser Gln Asp Tyr Gln 
                165                 170                 175     


Cys Ser Ala Leu Met Gly Gly Arg Lys Val Met Ser Ile Ser Ile Arg 
            180                 185                 190         


Leu Lys Val Gln Lys Val Ile Pro Gly Pro Pro Ala Leu Thr Leu Val 
        195                 200                 205             


Pro Ala Glu Leu Val Arg Ile Arg Gly Glu Ala Ala Gln Ile Val Cys 
    210                 215                 220                 


Ser Ala Ser Ser Val Asp Val Asn Phe Asp Val Phe Leu Gln His Asn 
225                 230                 235                 240 


Asn Thr Lys Leu Ala Ile Pro Gln Gln Ser Asp Phe His Asn Asn Arg 
                245                 250                 255     


Tyr Gln Lys Val Leu Thr Leu Asn Leu Asp Gln Val Asp Phe Gln His 
            260                 265                 270         


Ala Gly Asn Tyr Ser Cys Val Ala Ser Asn Val Gln Gly Lys His Ser 
        275                 280                 285             


Thr Ser Met Phe Phe Arg Val Val Glu Ser Ala Tyr Leu Asn Leu Ser 
    290                 295                 300                 


Ser Glu Gln Asn Leu Ile Gln Glu Val Thr Val Gly Glu Gly Leu Asn 
305                 310                 315                 320 


Leu Lys Val Met Val Glu Ala Tyr Pro Gly Leu Gln Gly Phe Asn Trp 
                325                 330                 335     


Thr Tyr Leu Gly Pro Phe Ser Asp His Gln Pro Glu Pro Lys Leu Ala 
            340                 345                 350         


Asn Ala Thr Thr Lys Asp Thr Tyr Arg His Thr Phe Thr Leu Ser Leu 
        355                 360                 365             


Pro Arg Leu Lys Pro Ser Glu Ala Gly Arg Tyr Ser Phe Leu Ala Arg 
    370                 375                 380                 


Asn Pro Gly Gly Trp Arg Ala Leu Thr Phe Glu Leu Thr Leu Arg Tyr 
385                 390                 395                 400 


Pro Pro Glu Val Ser Val Ile Trp Thr Phe Ile Asn Gly Ser Gly Thr 
                405                 410                 415     


Leu Leu Cys Ala Ala Ser Gly Tyr Pro Gln Pro Asn Val Thr Trp Leu 
            420                 425                 430         


Gln Cys Ser Gly His Thr Asp Arg Cys Asp Glu Ala Gln Val Leu Gln 
        435                 440                 445             


Val Trp Asp Asp Pro Tyr Pro Glu Val Leu Ser Gln Glu Pro Phe His 
    450                 455                 460                 


Lys Val Thr Val Gln Ser Leu Leu Thr Val Glu Thr Leu Glu His Asn 
465                 470                 475                 480 


Gln Thr Tyr Glu Cys Arg Ala His Asn Ser Val Gly Ser Gly Ser Trp 
                485                 490                 495     


Ala Phe Ile Pro Ile Ser Ala Gly Ala His Thr His Pro Pro Asp Glu 
            500                 505                 510         


Phe Leu Phe Thr Pro Val Val Val Ala Cys Met Ser Ile Met Ala Leu 
        515                 520                 525             


Leu Leu Leu Leu Leu Leu Leu Leu Leu Tyr Lys Tyr Lys Gln Lys Pro 
    530                 535                 540                 


Lys Tyr Gln Val Arg Trp Lys Ile Ile Glu Ser Tyr Glu Gly Asn Ser 
545                 550                 555                 560 


Tyr Thr Phe Ile Asp Pro Thr Gln Leu Pro Tyr Asn Glu Lys Trp Glu 
                565                 570                 575     


Phe Pro Arg Asn Asn Leu Gln Phe Gly Lys Thr Leu Gly Ala Gly Ala 
            580                 585                 590         


Phe Gly Lys Val Val Glu Ala Thr Ala Phe Gly Leu Gly Lys Glu Asp 
        595                 600                 605             


Ala Val Leu Lys Val Ala Val Lys Met Leu Lys Ser Thr Ala His Ala 
    610                 615                 620                 


Asp Glu Lys Glu Ala Leu Met Ser Glu Leu Lys Ile Met Ser His Leu 
625                 630                 635                 640 


Gly Gln His Glu Asn Ile Val Asn Leu Leu Gly Ala Cys Thr His Gly 
                645                 650                 655     


Gly Pro Val Leu Val Ile Thr Glu Tyr Cys Cys Tyr Gly Asp Leu Leu 
            660                 665                 670         


Asn Phe Leu Arg Arg Lys Ala Glu Ala Met Leu Gly Pro Ser Leu Ser 
        675                 680                 685             


Pro Gly Gln Asp Pro Glu Gly Gly Val Asp Tyr Lys Asn Ile His Leu 
    690                 695                 700                 


Glu Lys Lys Tyr Val Arg Arg Asp Ser Gly Phe Ser Ser Gln Gly Val 
705                 710                 715                 720 


Asp Thr Tyr Val Glu Met Arg Pro Val Ser Thr Ser Ser Asn Asp Ser 
                725                 730                 735     


Phe Ser Glu Gln Asp Leu Asp Lys Glu Asp Gly Arg Pro Leu Glu Leu 
            740                 745                 750         


Arg Asp Leu Leu His Phe Ser Ser Gln Val Ala Gln Gly Met Ala Phe 
        755                 760                 765             


Leu Ala Ser Lys Asn Cys Ile His Arg Asp Val Ala Ala Arg Asn Val 
    770                 775                 780                 


Leu Leu Thr Asn Gly His Val Ala Lys Ile Gly Asp Phe Gly Leu Ala 
785                 790                 795                 800 


Arg Asp Ile Met Asn Asp Ser Asn Tyr Ile Val Lys Gly Asn Ala Arg 
                805                 810                 815     


Leu Pro Val Lys Trp Met Ala Pro Glu Ser Ile Phe Asp Cys Val Tyr 
            820                 825                 830         


Thr Val Gln Ser Asp Val Trp Ser Tyr Gly Ile Leu Leu Trp Glu Ile 
        835                 840                 845             


Phe Ser Leu Gly Leu Asn Pro Tyr Pro Gly Ile Leu Val Asn Ser Lys 
    850                 855                 860                 


Phe Tyr Lys Leu Val Lys Asp Gly Tyr Gln Met Ala Gln Pro Ala Phe 
865                 870                 875                 880 


Ala Pro Lys Asn Ile Tyr Ser Ile Met Gln Ala Cys Trp Ala Leu Glu 
                885                 890                 895     


Pro Thr His Arg Pro Thr Phe Gln Gln Ile Cys Ser Phe Leu Gln Glu 
            900                 905                 910         


Gln Ala Gln Glu Asp Arg Arg Glu Arg Asp Tyr Thr Asn Leu Pro Ser 
        915                 920                 925             


Ser Ser Arg Ser Gly Gly Ser Gly Ser Ser Ser Ser Glu Leu Glu Glu 
    930                 935                 940                 


Glu Ser Ser Ser Glu His Leu Thr Cys Cys Glu Gln Gly Asp Ile Ala 
945                 950                 955                 960 


Gln Pro Leu Leu Gln Pro Asn Asn Tyr Gln Phe Cys 
                965                 970         


<210>  353
<211>  491
<212>  PRT
<213>  Homo sapiens

<400>  353

Met Pro Gly Ala Arg Asp Ala Leu Cys His Gln Ala Leu Gln Leu Leu 
1               5                   10                  15      


Ala Glu Leu Cys Ala Arg Gly Ala Leu Glu His Asp Ser Cys Gln Asp 
            20                  25                  30          


Phe Ile Tyr His Leu Arg Asp Arg Ala Arg Pro Arg Leu Arg Asp Pro 
        35                  40                  45              


Asp Ile Ser Val Ser Leu Leu Thr Leu Val Val Thr Ala Cys Gly Leu 
    50                  55                  60                  


Ala Leu Phe Gly Val Ser Leu Phe Val Ser Trp Lys Leu Cys Trp Val 
65                  70                  75                  80  


Pro Trp Arg Glu Arg Gly Leu Pro Ser Gly Ser Lys Asp Asn Asn Gln 
                85                  90                  95      


Glu Pro Leu Asn Tyr Met Asp Thr Glu Thr Asn Glu Gln Glu Asn Ser 
            100                 105                 110         


Glu Asp Phe Leu Asp Pro Pro Thr Pro Cys Pro Asp Ser Ser Met Lys 
        115                 120                 125             


Ile Ser His Thr Ser Pro Asp Ile Pro Leu Ser Thr Gln Thr Gly Ile 
    130                 135                 140                 


Gln Glu Asn Cys Ala His Gly Val Arg Val Gln Arg Gln Val Thr Glu 
145                 150                 155                 160 


Pro Thr Ser Ser Ala Arg His Asn Ser Ile Arg Arg Gln Leu Asn Leu 
                165                 170                 175     


Ser Asn Pro Asp Phe Asn Ile Gln Gln Leu Gln Lys Gln Glu Gln Leu 
            180                 185                 190         


Thr Gly Ile Gly Arg Ile Lys Pro Glu Leu Tyr Lys Gln Arg Ser Leu 
        195                 200                 205             


Asp Asn Asp Asp Gly Arg Arg Ser Asn Ser Lys Ala Cys Gly Lys Leu 
    210                 215                 220                 


Asn Phe Ile Leu Lys Tyr Asp Cys Asp Leu Glu Gln Leu Ile Val Lys 
225                 230                 235                 240 


Ile His Lys Ala Val Asn Leu Pro Ala Lys Asp Phe Ser Gly Thr Ser 
                245                 250                 255     


Asp Pro Tyr Val Lys Ile Tyr Leu Leu Pro Asp Arg Lys Thr Lys His 
            260                 265                 270         


Gln Thr Lys Val His Arg Lys Thr Leu Asn Pro Val Phe Asp Glu Val 
        275                 280                 285             


Phe Leu Phe Pro Val Pro Tyr Asn Asp Leu Glu Ala Arg Lys Leu His 
    290                 295                 300                 


Phe Ser Val Tyr Asp Phe Asp Arg Phe Ser Arg His Asp Leu Ile Gly 
305                 310                 315                 320 


Gln Val Val Val Asp His Phe Leu Asp Leu Ala Asp Phe Pro Arg Glu 
                325                 330                 335     


Cys Ile Leu Trp Lys Asp Ile Glu Tyr Val Thr Asn Asp Asn Val Asp 
            340                 345                 350         


Leu Gly Glu Leu Met Phe Ser Leu Cys Tyr Leu Pro Thr Ala Gly Arg 
        355                 360                 365             


Leu Thr Ile Thr Ile Ile Lys Ala Arg Asn Leu Lys Ala Met Asp Ile 
    370                 375                 380                 


Thr Gly Ala Ser Asp Pro Tyr Val Lys Val Ser Leu Met Cys Asp Gly 
385                 390                 395                 400 


Arg Arg Leu Lys Lys Arg Lys Thr Ser Thr Lys Arg Asn Thr Leu Asn 
                405                 410                 415     


Pro Val Tyr Asn Glu Ala Ile Val Phe Asp Val Pro Pro Glu Asn Ile 
            420                 425                 430         


Asp Gln Ile His Leu Ser Ile Ala Val Met Asp Tyr Asp Arg Val Gly 
        435                 440                 445             


His Asn Glu Ile Ile Gly Val Cys Gln Val Gly Asn Glu Ala Glu Arg 
    450                 455                 460                 


Leu Gly Arg Asp His Trp Ser Glu Met Leu Ser Tyr Pro Arg Lys Pro 
465                 470                 475                 480 


Ile Ala His Trp His Ser Leu Val Glu Lys Arg 
                485                 490     


<210>  354
<211>  411
<212>  PRT
<213>  Homo sapiens

<400>  354

Met Glu Thr Pro Glu Val Pro Val Gly Ser Leu Ile Asp Phe Gly Pro 
1               5                   10                  15      


Glu Ala Pro Thr Ser Ser Pro Leu Glu Ala Pro Pro Pro Val Leu Gln 
            20                  25                  30          


Asp Gly Asp Gly Ser Leu Gly Asp Gly Ala Ser Glu Ser Glu Thr Thr 
        35                  40                  45              


Glu Ser Ala Asp Ser Glu Asn Asp Met Gly Glu Ser Pro Ser His Pro 
    50                  55                  60                  


Ser Trp Asp Gln Asp Arg Arg Ser Ser Ser Asn Glu Ser Phe Ser Ser 
65                  70                  75                  80  


Asn Gln Ser Thr Glu Ser Thr Gln Asp Glu Glu Thr Leu Ala Leu Arg 
                85                  90                  95      


Asp Phe Met Arg Gly Tyr Val Glu Lys Ile Phe Ser Gly Gly Glu Asp 
            100                 105                 110         


Leu Asp Gln Glu Glu Lys Ala Lys Phe Gly Glu Tyr Cys Ser Ser Glu 
        115                 120                 125             


Asn Gly Lys Gly Arg Glu Trp Phe Ala Arg Tyr Val Ser Ala Gln Arg 
    130                 135                 140                 


Cys Asn Ser Lys Cys Val Ser Glu Ala Thr Phe Tyr Arg Leu Val Gln 
145                 150                 155                 160 


Ser Phe Ala Val Val Leu Phe Glu Cys His Gln Met Asp Asp Phe Gly 
                165                 170                 175     


Pro Ala Lys Asn Leu Met Thr Met Cys Phe Thr Tyr Tyr His Ile Gly 
            180                 185                 190         


Lys Pro Gln Leu Leu Pro Pro Glu Ser Arg Glu Lys Pro Ala Gly Ser 
        195                 200                 205             


Ile Asp Ser Tyr Leu Lys Ser Ala Asn Ser Trp Leu Ala Glu Lys Lys 
    210                 215                 220                 


Asp Ile Ala Glu Arg Leu Leu Lys Asn Thr Ser Ala Arg Thr Glu Asn 
225                 230                 235                 240 


Val Lys Gly Phe Phe Gly Gly Leu Glu Thr Lys Leu Lys Gly Pro Leu 
                245                 250                 255     


Ala Arg Arg Asn Glu Glu Asp Glu Asn Lys Pro Gln Glu Lys Arg Pro 
            260                 265                 270         


Arg Ala Val Thr Ala Tyr Ser Pro Glu Asp Glu Lys Lys Gly Glu Lys 
        275                 280                 285             


Ile Tyr Leu Tyr Thr His Leu Lys Gln Gln Pro Ile Trp His Thr Leu 
    290                 295                 300                 


Arg Phe Trp Asn Ala Ala Phe Phe Asp Ala Val His Cys Glu Arg Thr 
305                 310                 315                 320 


Lys Arg Ser Pro Thr Thr Arg Gly Asp Ala Gly Glu Glu Glu Glu Lys 
                325                 330                 335     


Arg Glu Lys Trp Cys His Met Thr Gln Glu Glu Arg Asp Asp Ser Leu 
            340                 345                 350         


Arg Phe Asn Glu Asn Ile Thr Phe Gly Gln Leu Gly Thr Phe Thr His 
        355                 360                 365             


Asn Met Leu Ala Phe Gly Leu Asn Lys Lys Leu Cys Asn Asp Phe Leu 
    370                 375                 380                 


Lys Lys Gln Ala Val Ile Gly Asn Leu Asp Glu Glu Gln Tyr Lys Leu 
385                 390                 395                 400 


Leu Ser Asp His Ile Glu Gln Met Ala Thr Glu 
                405                 410     


<210>  355
<211>  591
<212>  PRT
<213>  Homo sapiens

<400>  355

Met Phe Gly Lys Arg Lys Lys Arg Val Glu Ile Ser Ala Pro Ser Asn 
1               5                   10                  15      


Phe Glu His Arg Val His Thr Gly Phe Asp Gln His Glu Gln Lys Phe 
            20                  25                  30          


Thr Gly Leu Pro Arg Gln Trp Gln Ser Leu Ile Glu Glu Ser Ala Arg 
        35                  40                  45              


Arg Pro Lys Pro Leu Val Asp Pro Ala Cys Ile Thr Ser Ile Gln Pro 
    50                  55                  60                  


Gly Ala Pro Lys Thr Ile Val Arg Gly Ser Lys Gly Ala Lys Asp Gly 
65                  70                  75                  80  


Ala Leu Thr Leu Leu Leu Asp Glu Phe Glu Asn Met Ser Val Thr Arg 
                85                  90                  95      


Ser Asn Ser Leu Arg Arg Asp Ser Pro Pro Pro Pro Ala Arg Ala Arg 
            100                 105                 110         


Gln Glu Asn Gly Met Pro Glu Glu Pro Ala Thr Thr Ala Arg Gly Gly 
        115                 120                 125             


Pro Gly Lys Ala Gly Ser Arg Gly Arg Phe Ala Gly His Ser Glu Ala 
    130                 135                 140                 


Gly Gly Gly Ser Gly Asp Arg Arg Arg Ala Gly Pro Glu Lys Arg Pro 
145                 150                 155                 160 


Lys Ser Ser Arg Glu Gly Ser Gly Gly Pro Gln Glu Ser Ser Arg Asp 
                165                 170                 175     


Lys Arg Pro Leu Ser Gly Pro Asp Val Gly Thr Pro Gln Pro Ala Gly 
            180                 185                 190         


Leu Ala Ser Gly Ala Lys Leu Ala Ala Gly Arg Pro Phe Asn Thr Tyr 
        195                 200                 205             


Pro Arg Ala Asp Thr Asp His Pro Ser Arg Gly Ala Gln Gly Glu Pro 
    210                 215                 220                 


His Asp Val Ala Pro Asn Gly Pro Ser Ala Gly Gly Leu Ala Ile Pro 
225                 230                 235                 240 


Gln Ser Ser Ser Ser Ser Ser Arg Pro Pro Thr Arg Ala Arg Gly Ala 
                245                 250                 255     


Pro Ser Pro Gly Val Leu Gly Pro His Ala Ser Glu Pro Gln Leu Ala 
            260                 265                 270         


Pro Pro Ala Cys Thr Pro Ala Ala Pro Ala Val Pro Gly Pro Pro Gly 
        275                 280                 285             


Pro Arg Ser Pro Gln Arg Glu Pro Gln Arg Val Ser His Glu Gln Phe 
    290                 295                 300                 


Arg Ala Ala Leu Gln Leu Val Val Asp Pro Gly Asp Pro Arg Ser Tyr 
305                 310                 315                 320 


Leu Asp Asn Phe Ile Lys Ile Gly Glu Gly Ser Thr Gly Ile Val Cys 
                325                 330                 335     


Ile Ala Thr Val Arg Ser Ser Gly Lys Leu Val Ala Val Lys Lys Met 
            340                 345                 350         


Asp Leu Arg Lys Gln Gln Arg Arg Glu Leu Leu Phe Asn Glu Val Val 
        355                 360                 365             


Ile Met Arg Asp Tyr Gln His Glu Asn Val Val Glu Met Tyr Asn Ser 
    370                 375                 380                 


Tyr Leu Val Gly Asp Glu Leu Trp Val Val Met Glu Phe Leu Glu Gly 
385                 390                 395                 400 


Gly Ala Leu Thr Asp Ile Val Thr His Thr Arg Met Asn Glu Glu Gln 
                405                 410                 415     


Ile Ala Ala Val Cys Leu Ala Val Leu Gln Ala Leu Ser Val Leu His 
            420                 425                 430         


Ala Gln Gly Val Ile His Arg Asp Ile Lys Ser Asp Ser Ile Leu Leu 
        435                 440                 445             


Thr His Asp Gly Arg Val Lys Leu Ser Asp Phe Gly Phe Cys Ala Gln 
    450                 455                 460                 


Val Ser Lys Glu Val Pro Arg Arg Lys Ser Leu Val Gly Thr Pro Tyr 
465                 470                 475                 480 


Trp Met Ala Pro Glu Leu Ile Ser Arg Leu Pro Tyr Gly Pro Glu Val 
                485                 490                 495     


Asp Ile Trp Ser Leu Gly Ile Met Val Ile Glu Met Val Asp Gly Glu 
            500                 505                 510         


Pro Pro Tyr Phe Asn Glu Pro Pro Leu Lys Ala Met Lys Met Ile Arg 
        515                 520                 525             


Asp Asn Leu Pro Pro Arg Leu Lys Asn Leu His Lys Val Ser Pro Ser 
    530                 535                 540                 


Leu Lys Gly Phe Leu Asp Arg Leu Leu Val Arg Asp Pro Ala Gln Arg 
545                 550                 555                 560 


Ala Thr Ala Ala Glu Leu Leu Lys His Pro Phe Leu Ala Lys Ala Gly 
                565                 570                 575     


Pro Pro Ala Ser Ile Val Pro Leu Met Arg Gln Asn Arg Thr Arg 
            580                 585                 590     


<210>  356
<211>  475
<212>  PRT
<213>  Homo sapiens

<400>  356

Met Ala Ser Ala Ala Arg Leu Thr Met Met Trp Glu Glu Val Thr Cys 
1               5                   10                  15      


Pro Ile Cys Leu Asp Pro Phe Val Glu Pro Val Ser Ile Glu Cys Gly 
            20                  25                  30          


His Ser Phe Cys Gln Glu Cys Ile Ser Gln Val Gly Lys Gly Gly Gly 
        35                  40                  45              


Ser Val Cys Pro Val Cys Arg Gln Arg Phe Leu Leu Lys Asn Leu Arg 
    50                  55                  60                  


Pro Asn Arg Gln Leu Ala Asn Met Val Asn Asn Leu Lys Glu Ile Ser 
65                  70                  75                  80  


Gln Glu Ala Arg Glu Gly Thr Gln Gly Glu Arg Cys Ala Val His Gly 
                85                  90                  95      


Glu Arg Leu His Leu Phe Cys Glu Lys Asp Gly Lys Ala Leu Cys Trp 
            100                 105                 110         


Val Cys Ala Gln Ser Arg Lys His Arg Asp His Ala Met Val Pro Leu 
        115                 120                 125             


Glu Glu Ala Ala Gln Glu Tyr Gln Glu Lys Leu Gln Val Ala Leu Gly 
    130                 135                 140                 


Glu Leu Arg Arg Lys Gln Glu Leu Ala Glu Lys Leu Glu Val Glu Ile 
145                 150                 155                 160 


Ala Ile Lys Arg Ala Asp Trp Lys Lys Thr Val Glu Thr Gln Lys Ser 
                165                 170                 175     


Arg Ile His Ala Glu Phe Val Gln Gln Lys Asn Phe Leu Val Glu Glu 
            180                 185                 190         


Glu Gln Arg Gln Leu Gln Glu Leu Glu Lys Asp Glu Arg Glu Gln Leu 
        195                 200                 205             


Arg Ile Leu Gly Glu Lys Glu Ala Lys Leu Ala Gln Gln Ser Gln Ala 
    210                 215                 220                 


Leu Gln Glu Leu Ile Ser Glu Leu Asp Arg Arg Cys His Ser Ser Ala 
225                 230                 235                 240 


Leu Glu Leu Leu Gln Glu Val Ile Ile Val Leu Glu Arg Ser Glu Ser 
                245                 250                 255     


Trp Asn Leu Lys Asp Leu Asp Ile Thr Ser Pro Glu Leu Arg Ser Val 
            260                 265                 270         


Cys His Val Pro Gly Leu Lys Lys Met Leu Arg Thr Cys Ala Val His 
        275                 280                 285             


Ile Thr Leu Asp Pro Asp Thr Ala Asn Pro Trp Leu Ile Leu Ser Glu 
    290                 295                 300                 


Asp Arg Arg Gln Val Arg Leu Gly Asp Thr Gln Gln Ser Ile Pro Gly 
305                 310                 315                 320 


Asn Glu Glu Arg Phe Asp Ser Tyr Pro Met Val Leu Gly Ala Gln His 
                325                 330                 335     


Phe His Ser Gly Lys His Tyr Trp Glu Val Asp Val Thr Gly Lys Glu 
            340                 345                 350         


Ala Trp Asp Leu Gly Val Cys Arg Asp Ser Val Arg Arg Lys Gly His 
        355                 360                 365             


Phe Leu Leu Ser Ser Lys Ser Gly Phe Trp Thr Ile Trp Leu Trp Asn 
    370                 375                 380                 


Lys Gln Lys Tyr Glu Ala Gly Thr Tyr Pro Gln Thr Pro Leu His Leu 
385                 390                 395                 400 


Gln Val Pro Pro Cys Gln Val Gly Ile Phe Leu Asp Tyr Glu Ala Gly 
                405                 410                 415     


Met Val Ser Phe Tyr Asn Ile Thr Asp His Gly Ser Leu Ile Tyr Ser 
            420                 425                 430         


Phe Ser Glu Cys Ala Phe Thr Gly Pro Leu Arg Pro Phe Phe Ser Pro 
        435                 440                 445             


Gly Phe Asn Asp Gly Gly Lys Asn Thr Ala Pro Leu Thr Leu Cys Pro 
    450                 455                 460                 


Leu Asn Ile Gly Ser Gln Gly Ser Thr Asp Tyr 
465                 470                 475 


<210>  357
<211>  218
<212>  PRT
<213>  Homo sapiens

<400>  357

Met Gly Arg Leu Leu Ala Leu Val Val Gly Ala Ala Leu Val Ser Ser 
1               5                   10                  15      


Ala Cys Gly Gly Cys Val Glu Val Asp Ser Glu Thr Glu Ala Val Tyr 
            20                  25                  30          


Gly Met Thr Phe Lys Ile Leu Cys Ile Ser Cys Lys Arg Arg Ser Glu 
        35                  40                  45              


Thr Asn Ala Glu Thr Phe Thr Glu Trp Thr Phe Arg Gln Lys Gly Thr 
    50                  55                  60                  


Glu Glu Phe Val Lys Ile Leu Arg Tyr Glu Asn Glu Val Leu Gln Leu 
65                  70                  75                  80  


Glu Glu Asp Glu Arg Phe Glu Gly Arg Val Val Trp Asn Gly Ser Arg 
                85                  90                  95      


Gly Thr Lys Asp Leu Gln Asp Leu Ser Ile Phe Ile Thr Asn Val Thr 
            100                 105                 110         


Tyr Asn His Ser Gly Asp Tyr Glu Cys His Val Tyr Arg Leu Leu Phe 
        115                 120                 125             


Phe Glu Asn Tyr Glu His Asn Thr Ser Val Val Lys Lys Ile His Ile 
    130                 135                 140                 


Glu Val Val Asp Lys Ala Asn Arg Asp Met Ala Ser Ile Val Ser Glu 
145                 150                 155                 160 


Ile Met Met Tyr Val Leu Ile Val Val Leu Thr Ile Trp Leu Val Ala 
                165                 170                 175     


Glu Met Ile Tyr Cys Tyr Lys Lys Ile Ala Ala Ala Thr Glu Thr Ala 
            180                 185                 190         


Ala Gln Glu Asn Ala Ser Glu Tyr Leu Ala Ile Thr Ser Glu Ser Lys 
        195                 200                 205             


Glu Asn Cys Thr Gly Val Gln Val Ala Glu 
    210                 215             


<210>  358
<211>  261
<212>  PRT
<213>  Homo sapiens

<400>  358

Met Ala Leu Asn Lys Asn His Ser Glu Gly Gly Gly Val Ile Val Asn 
1               5                   10                  15      


Asn Thr Glu Ser Ile Leu Met Ser Tyr Asp His Val Glu Leu Thr Phe 
            20                  25                  30          


Asn Asp Met Lys Asn Val Pro Glu Ala Phe Lys Gly Thr Lys Lys Gly 
        35                  40                  45              


Thr Val Tyr Leu Thr Pro Tyr Arg Val Ile Phe Leu Ser Lys Gly Lys 
    50                  55                  60                  


Asp Ala Met Gln Ser Phe Met Met Pro Phe Tyr Leu Met Lys Asp Cys 
65                  70                  75                  80  


Glu Ile Lys Gln Pro Val Phe Gly Ala Asn Tyr Ile Lys Gly Thr Val 
                85                  90                  95      


Lys Ala Glu Ala Gly Gly Gly Trp Glu Gly Ser Ala Ser Tyr Lys Leu 
            100                 105                 110         


Thr Phe Thr Ala Gly Gly Ala Ile Glu Phe Gly Gln Arg Met Leu Gln 
        115                 120                 125             


Val Ala Ser Gln Ala Ser Arg Gly Glu Val Pro Ser Gly Ala Tyr Gly 
    130                 135                 140                 


Tyr Ser Tyr Met Pro Ser Gly Ala Tyr Val Tyr Pro Pro Pro Val Ala 
145                 150                 155                 160 


Asn Gly Met Tyr Pro Cys Pro Pro Gly Tyr Pro Tyr Pro Pro Pro Pro 
                165                 170                 175     


Pro Glu Phe Tyr Pro Gly Pro Pro Met Met Asp Gly Ala Met Gly Tyr 
            180                 185                 190         


Val Gln Pro Pro Pro Pro Pro Tyr Pro Gly Pro Met Glu Pro Pro Val 
        195                 200                 205             


Ser Gly Pro Asp Val Pro Ser Thr Pro Ala Ala Glu Ala Lys Ala Ala 
    210                 215                 220                 


Glu Ala Ala Ala Ser Ala Tyr Tyr Asn Pro Gly Asn Pro His Asn Val 
225                 230                 235                 240 


Tyr Met Pro Thr Ser Gln Pro Pro Pro Pro Pro Tyr Tyr Pro Pro Glu 
                245                 250                 255     


Asp Lys Lys Thr Gln 
            260     


<210>  359
<211>  311
<212>  PRT
<213>  Homo sapiens

<400>  359

Met Leu Thr Lys Pro Leu Gln Gly Pro Pro Ala Pro Pro Gly Thr Pro 
1               5                   10                  15      


Thr Pro Pro Pro Gly Gly Lys Asp Arg Glu Ala Phe Glu Ala Glu Tyr 
            20                  25                  30          


Arg Leu Gly Pro Leu Leu Gly Lys Gly Gly Phe Gly Thr Val Phe Ala 
        35                  40                  45              


Gly His Arg Leu Thr Asp Arg Leu Gln Val Ala Ile Lys Val Ile Pro 
    50                  55                  60                  


Arg Asn Arg Val Leu Gly Trp Ser Pro Leu Ser Asp Ser Val Thr Cys 
65                  70                  75                  80  


Pro Leu Glu Val Ala Leu Leu Trp Lys Val Gly Ala Gly Gly Gly His 
                85                  90                  95      


Pro Gly Val Ile Arg Leu Leu Asp Trp Phe Glu Thr Gln Glu Gly Phe 
            100                 105                 110         


Met Leu Val Leu Glu Arg Pro Leu Pro Ala Gln Asp Leu Phe Asp Tyr 
        115                 120                 125             


Ile Thr Glu Lys Gly Pro Leu Gly Glu Gly Pro Ser Arg Cys Phe Phe 
    130                 135                 140                 


Gly Gln Val Val Ala Ala Ile Gln His Cys His Ser Arg Gly Val Val 
145                 150                 155                 160 


His Arg Asp Ile Lys Asp Glu Asn Ile Leu Ile Asp Leu Arg Arg Gly 
                165                 170                 175     


Cys Ala Lys Leu Ile Asp Phe Gly Ser Gly Ala Leu Leu His Asp Glu 
            180                 185                 190         


Pro Tyr Thr Asp Phe Asp Gly Thr Arg Val Tyr Ser Pro Pro Glu Trp 
        195                 200                 205             


Ile Ser Arg His Gln Tyr His Ala Leu Pro Ala Thr Val Trp Ser Leu 
    210                 215                 220                 


Gly Ile Leu Leu Tyr Asp Met Val Cys Gly Asp Ile Pro Phe Glu Arg 
225                 230                 235                 240 


Asp Gln Glu Ile Leu Glu Ala Glu Leu His Phe Pro Ala His Val Ser 
                245                 250                 255     


Pro Asp Cys Cys Ala Leu Ile Arg Arg Cys Leu Ala Pro Lys Pro Ser 
            260                 265                 270         


Ser Arg Pro Ser Leu Glu Glu Ile Leu Leu Asp Pro Trp Met Gln Thr 
        275                 280                 285             


Pro Ala Glu Asp Val Pro Leu Asn Pro Ser Lys Gly Gly Pro Ala Pro 
    290                 295                 300                 


Leu Ala Trp Ser Leu Leu Pro 
305                 310     


<210>  360
<211>  222
<212>  PRT
<213>  Homo sapiens

<400>  360

Met Glu Ile Pro Pro Thr Asn Tyr Pro Ala Ser Arg Ala Ala Leu Val 
1               5                   10                  15      


Ala Gln Asn Tyr Ile Asn Tyr Gln Gln Gly Thr Pro His Arg Val Phe 
            20                  25                  30          


Glu Val Gln Lys Val Lys Gln Ala Ser Met Glu Asp Ile Pro Gly Arg 
        35                  40                  45              


Gly His Lys Tyr His Leu Lys Phe Ala Val Glu Glu Ile Ile Gln Lys 
    50                  55                  60                  


Gln Val Lys Val Asn Cys Thr Ala Glu Val Leu Tyr Pro Ser Thr Gly 
65                  70                  75                  80  


Gln Glu Thr Ala Pro Glu Val Asn Phe Thr Phe Glu Gly Glu Thr Gly 
                85                  90                  95      


Lys Asn Pro Asp Glu Glu Asp Asn Thr Phe Tyr Gln Arg Leu Lys Ser 
            100                 105                 110         


Met Lys Glu Pro Leu Glu Ala Gln Asn Ile Pro Asp Asn Phe Gly Asn 
        115                 120                 125             


Val Ser Pro Glu Met Thr Leu Val Leu His Leu Ala Trp Val Ala Cys 
    130                 135                 140                 


Gly Tyr Ile Ile Trp Gln Asn Ser Thr Glu Asp Thr Trp Tyr Lys Met 
145                 150                 155                 160 


Val Lys Ile Gln Thr Val Lys Gln Val Gln Arg Asn Asp Asp Phe Ile 
                165                 170                 175     


Glu Leu Asp Tyr Thr Ile Leu Leu His Asn Ile Ala Ser Gln Glu Ile 
            180                 185                 190         


Ile Pro Trp Gln Met Gln Val Leu Trp His Pro Gln Tyr Gly Thr Lys 
        195                 200                 205             


Val Lys His Asn Ser Arg Leu Pro Lys Glu Val Gln Leu Glu 
    210                 215                 220         


<210>  361
<211>  125
<212>  PRT
<213>  Homo sapiens

<400>  361

Met Ser Ser Thr Leu Gly Lys Leu Ser Asn Gln Val Glu Glu Thr Leu 
1               5                   10                  15      


Pro Leu Leu Lys Lys Val Pro Ala Asn Tyr Phe His Ile Cys Ser Ala 
            20                  25                  30          


Ile Leu Met Gly Phe Ser Leu Ser Lys Ser Ala Thr Gln Val Ser Ala 
        35                  40                  45              


Ile His Met Asp Ser Lys Val Asp Asp His Leu Ile Arg Gly Thr Glu 
    50                  55                  60                  


Lys Ser Arg Leu Glu Pro Ala Thr Gln Leu Phe Gln Asn Thr Lys Lys 
65                  70                  75                  80  


Ile Arg Leu Glu Asp Thr Asn Gln Glu Asn Phe Thr Arg Ile Glu Gly 
                85                  90                  95      


Thr Gly Thr Gly Ser Leu Ser Gly Lys Ala Leu Gly Ser Val Val Tyr 
            100                 105                 110         


Val Lys Glu Ser Asp Gly Leu Glu Met Thr Asp Val Glu 
        115                 120                 125 


<210>  362
<211>  363
<212>  PRT
<213>  Homo sapiens

<400>  362

Met Phe Lys Arg His Lys Ser Leu Ala Ser Glu Arg Lys Arg Ala Leu 
1               5                   10                  15      


Leu Ser Gln Arg Ala Thr Arg Phe Ile Leu Lys Asp Asp Met Arg Asn 
            20                  25                  30          


Phe His Phe Leu Ser Lys Leu Val Leu Ser Ala Gly Pro Leu Arg Pro 
        35                  40                  45              


Thr Pro Ala Val Lys His Ser Lys Thr Thr His Phe Glu Ile Glu Ile 
    50                  55                  60                  


Phe Asp Ala Gln Thr Arg Lys Gln Ile Cys Ile Leu Asp Lys Val Thr 
65                  70                  75                  80  


Gln Ser Ser Thr Ile His Asp Val Lys Gln Lys Phe His Lys Ala Cys 
                85                  90                  95      


Pro Lys Trp Tyr Pro Ser Arg Val Gly Leu Gln Leu Glu Cys Gly Gly 
            100                 105                 110         


Pro Phe Leu Lys Asp Tyr Ile Thr Ile Gln Ser Ile Ala Ala Ser Ser 
        115                 120                 125             


Ile Val Thr Leu Tyr Ala Thr Asp Leu Gly Gln Gln Val Ser Trp Thr 
    130                 135                 140                 


Thr Val Phe Leu Ala Glu Tyr Thr Gly Pro Leu Leu Ile Tyr Leu Leu 
145                 150                 155                 160 


Phe Tyr Leu Arg Ile Pro Cys Ile Tyr Asp Gly Lys Glu Ser Ala Arg 
                165                 170                 175     


Arg Leu Arg His Pro Val Val His Leu Ala Cys Phe Cys His Cys Ile 
            180                 185                 190         


His Tyr Ile Arg Tyr Leu Leu Glu Thr Leu Phe Val His Lys Val Ser 
        195                 200                 205             


Ala Gly His Thr Pro Leu Lys Asn Leu Ile Met Ser Cys Ala Phe Tyr 
    210                 215                 220                 


Trp Gly Phe Thr Ser Trp Ile Ala Tyr Tyr Ile Asn His Pro Leu Tyr 
225                 230                 235                 240 


Thr Pro Pro Ser Phe Gly Asn Arg Gln Ile Thr Val Ser Ala Ile Asn 
                245                 250                 255     


Phe Leu Ile Cys Glu Ala Gly Asn His Phe Ile Asn Val Met Leu Ser 
            260                 265                 270         


His Pro Asn His Thr Gly Asn Asn Ala Cys Phe Pro Ser Pro Asn Tyr 
        275                 280                 285             


Asn Pro Phe Thr Trp Met Phe Phe Leu Val Ser Cys Pro Asn Tyr Thr 
    290                 295                 300                 


Tyr Glu Ile Gly Ser Trp Ile Ser Phe Thr Val Met Thr Gln Thr Leu 
305                 310                 315                 320 


Pro Val Gly Ile Phe Thr Leu Leu Met Ser Ile Gln Met Ser Leu Trp 
                325                 330                 335     


Ala Gln Lys Lys His Lys Ile Tyr Leu Arg Lys Phe Asn Ser Tyr Ile 
            340                 345                 350         


His Arg Lys Ser Ala Met Ile Pro Phe Ile Leu 
        355                 360             


<210>  363
<211>  548
<212>  PRT
<213>  Homo sapiens

<400>  363

Met Ser Ala Ser Leu Asn Tyr Lys Ser Phe Ser Lys Glu Gln Gln Thr 
1               5                   10                  15      


Met Asp Asn Leu Glu Lys Gln Leu Ile Cys Pro Ile Cys Leu Glu Met 
            20                  25                  30          


Phe Thr Lys Pro Val Val Ile Leu Pro Cys Gln His Asn Leu Cys Arg 
        35                  40                  45              


Lys Cys Ala Ser Asp Ile Phe Gln Ala Ser Asn Pro Tyr Leu Pro Thr 
    50                  55                  60                  


Arg Gly Gly Thr Thr Met Ala Ser Gly Gly Arg Phe Arg Cys Pro Ser 
65                  70                  75                  80  


Cys Arg His Glu Val Val Leu Asp Arg His Gly Val Tyr Gly Leu Gln 
                85                  90                  95      


Arg Asn Leu Leu Val Glu Asn Ile Ile Asp Ile Tyr Lys Gln Glu Ser 
            100                 105                 110         


Thr Arg Pro Glu Lys Lys Ser Asp Gln Pro Met Cys Glu Glu His Glu 
        115                 120                 125             


Glu Glu Arg Ile Asn Ile Tyr Cys Leu Asn Cys Glu Val Pro Thr Cys 
    130                 135                 140                 


Ser Leu Cys Lys Val Phe Gly Ala His Lys Asp Cys Gln Val Ala Pro 
145                 150                 155                 160 


Leu Thr His Val Phe Gln Arg Gln Lys Ser Glu Leu Ser Asp Gly Ile 
                165                 170                 175     


Ala Ile Leu Val Gly Ser Asn Asp Arg Val Gln Gly Val Ile Ser Gln 
            180                 185                 190         


Leu Glu Asp Thr Cys Lys Thr Ile Glu Glu Cys Cys Arg Lys Gln Lys 
        195                 200                 205             


Gln Glu Leu Cys Glu Lys Phe Asp Tyr Leu Tyr Gly Ile Leu Glu Glu 
    210                 215                 220                 


Arg Lys Asn Glu Met Thr Gln Val Ile Thr Arg Thr Gln Glu Glu Lys 
225                 230                 235                 240 


Leu Glu His Val Arg Ala Leu Ile Lys Lys Tyr Ser Asp His Leu Glu 
                245                 250                 255     


Asn Val Ser Lys Leu Val Glu Ser Gly Ile Gln Phe Met Asp Glu Pro 
            260                 265                 270         


Glu Met Ala Val Phe Leu Gln Asn Ala Lys Thr Leu Leu Lys Lys Ile 
        275                 280                 285             


Ser Glu Ala Ser Lys Ala Phe Gln Met Glu Lys Ile Glu His Gly Tyr 
    290                 295                 300                 


Glu Asn Met Asn His Phe Thr Val Asn Leu Asn Arg Glu Glu Lys Ile 
305                 310                 315                 320 


Ile Arg Glu Ile Asp Phe Tyr Arg Glu Asp Glu Asp Glu Glu Glu Glu 
                325                 330                 335     


Glu Gly Gly Glu Gly Glu Lys Glu Gly Glu Gly Glu Val Gly Gly Glu 
            340                 345                 350         


Ala Val Glu Val Glu Glu Val Glu Asn Val Gln Thr Glu Phe Pro Gly 
        355                 360                 365             


Glu Asp Glu Asn Pro Glu Lys Ala Ser Glu Leu Ser Gln Val Glu Leu 
    370                 375                 380                 


Gln Ala Ala Pro Gly Ala Leu Pro Val Ser Ser Pro Glu Pro Pro Pro 
385                 390                 395                 400 


Ala Leu Pro Pro Ala Ala Asp Ala Pro Val Thr Gln Gly Glu Val Val 
                405                 410                 415     


Pro Thr Gly Ser Glu Gln Thr Thr Glu Ser Glu Thr Pro Val Pro Ala 
            420                 425                 430         


Ala Ala Glu Thr Ala Asp Pro Leu Phe Tyr Pro Ser Trp Tyr Lys Gly 
        435                 440                 445             


Gln Thr Arg Lys Ala Thr Thr Asn Pro Pro Cys Thr Pro Gly Ser Glu 
    450                 455                 460                 


Gly Leu Gly Gln Ile Gly Pro Pro Gly Ser Glu Asp Ser Asn Val Arg 
465                 470                 475                 480 


Lys Ala Glu Val Ala Ala Ala Ala Ala Ser Glu Arg Ala Ala Val Ser 
                485                 490                 495     


Gly Lys Glu Thr Ser Ala Pro Ala Ala Thr Ser Gln Ile Gly Phe Glu 
            500                 505                 510         


Ala Pro Pro Leu Gln Gly Gln Ala Ala Ala Pro Ala Ser Gly Ser Gly 
        515                 520                 525             


Ala Asp Ser Glu Pro Ala Arg His Ile Phe Ser Phe Ser Trp Leu Asn 
    530                 535                 540                 


Ser Leu Asn Glu 
545             


<210>  364
<211>  365
<212>  PRT
<213>  Homo sapiens

<400>  364

Met Ser Leu Ile Arg Lys Lys Gly Phe Tyr Lys Gln Asp Val Asn Lys 
1               5                   10                  15      


Thr Ala Trp Glu Leu Pro Lys Thr Tyr Val Ser Pro Thr His Val Gly 
            20                  25                  30          


Ser Gly Ala Tyr Gly Ser Val Cys Ser Ala Ile Asp Lys Arg Ser Gly 
        35                  40                  45              


Glu Lys Val Ala Ile Lys Lys Leu Ser Arg Pro Phe Gln Ser Glu Ile 
    50                  55                  60                  


Phe Ala Lys Arg Ala Tyr Arg Glu Leu Leu Leu Leu Lys His Met Gln 
65                  70                  75                  80  


His Glu Asn Val Ile Gly Leu Leu Asp Val Phe Thr Pro Ala Ser Ser 
                85                  90                  95      


Leu Arg Asn Phe Tyr Asp Phe Tyr Leu Val Met Pro Phe Met Gln Thr 
            100                 105                 110         


Asp Leu Gln Lys Ile Met Gly Met Glu Phe Ser Glu Glu Lys Ile Gln 
        115                 120                 125             


Tyr Leu Val Tyr Gln Met Leu Lys Gly Leu Lys Tyr Ile His Ser Ala 
    130                 135                 140                 


Gly Val Val His Arg Asp Leu Lys Pro Gly Asn Leu Ala Val Asn Glu 
145                 150                 155                 160 


Asp Cys Glu Leu Lys Ile Leu Asp Phe Gly Leu Ala Arg His Ala Asp 
                165                 170                 175     


Ala Glu Met Thr Gly Tyr Val Val Thr Arg Trp Tyr Arg Ala Pro Glu 
            180                 185                 190         


Val Ile Leu Ser Trp Met His Tyr Asn Gln Thr Val Asp Ile Trp Ser 
        195                 200                 205             


Val Gly Cys Ile Met Ala Glu Met Leu Thr Gly Lys Thr Leu Phe Lys 
    210                 215                 220                 


Gly Lys Asp Tyr Leu Asp Gln Leu Thr Gln Ile Leu Lys Val Thr Gly 
225                 230                 235                 240 


Val Pro Gly Thr Glu Phe Val Gln Lys Leu Asn Asp Lys Ala Ala Lys 
                245                 250                 255     


Ser Tyr Ile Gln Ser Leu Pro Gln Thr Pro Arg Lys Asp Phe Thr Gln 
            260                 265                 270         


Leu Phe Pro Arg Ala Ser Pro Gln Ala Ala Asp Leu Leu Glu Lys Met 
        275                 280                 285             


Leu Glu Leu Asp Val Asp Lys Arg Leu Thr Ala Ala Gln Ala Leu Thr 
    290                 295                 300                 


His Pro Phe Phe Glu Pro Phe Arg Asp Pro Glu Glu Glu Thr Glu Ala 
305                 310                 315                 320 


Gln Gln Pro Phe Asp Asp Ser Leu Glu His Glu Lys Leu Thr Val Asp 
                325                 330                 335     


Glu Trp Lys Gln His Ile Tyr Lys Glu Ile Val Asn Phe Ser Pro Ile 
            340                 345                 350         


Ala Arg Lys Asp Ser Arg Arg Arg Ser Gly Met Lys Leu 
        355                 360                 365 


<210>  365
<211>  858
<212>  PRT
<213>  Homo sapiens

<400>  365

Met Ser Val Val Gly Leu Asp Val Gly Ser Gln Ser Cys Tyr Ile Ala 
1               5                   10                  15      


Val Ala Arg Ala Gly Gly Ile Glu Thr Ile Ala Asn Glu Phe Ser Asp 
            20                  25                  30          


Arg Cys Thr Pro Ser Val Ile Ser Phe Gly Ser Lys Asn Arg Thr Ile 
        35                  40                  45              


Gly Val Ala Ala Lys Asn Gln Gln Ile Thr His Ala Asn Asn Thr Val 
    50                  55                  60                  


Ser Asn Phe Lys Arg Phe His Gly Arg Ala Phe Asn Asp Pro Phe Ile 
65                  70                  75                  80  


Gln Lys Glu Lys Glu Asn Leu Ser Tyr Asp Leu Val Pro Leu Lys Asn 
                85                  90                  95      


Gly Gly Val Gly Ile Lys Val Met Tyr Met Gly Glu Glu His Leu Phe 
            100                 105                 110         


Ser Val Glu Gln Ile Thr Ala Met Leu Leu Thr Lys Leu Lys Glu Thr 
        115                 120                 125             


Ala Glu Asn Ser Leu Lys Lys Pro Val Thr Asp Cys Val Ile Ser Val 
    130                 135                 140                 


Pro Ser Phe Phe Thr Asp Ala Glu Arg Arg Ser Val Leu Asp Ala Ala 
145                 150                 155                 160 


Gln Ile Val Gly Leu Asn Cys Leu Arg Leu Met Asn Asp Met Thr Ala 
                165                 170                 175     


Val Ala Leu Asn Tyr Gly Ile Tyr Lys Gln Asp Leu Pro Ser Leu Asp 
            180                 185                 190         


Glu Lys Pro Arg Ile Val Val Phe Val Asp Met Gly His Ser Ala Phe 
        195                 200                 205             


Gln Val Ser Ala Cys Ala Phe Asn Lys Gly Lys Leu Lys Val Leu Gly 
    210                 215                 220                 


Thr Ala Phe Asp Pro Phe Leu Gly Gly Lys Asn Phe Asp Glu Lys Leu 
225                 230                 235                 240 


Val Glu His Phe Cys Ala Glu Phe Lys Thr Lys Tyr Lys Leu Asp Ala 
                245                 250                 255     


Lys Ser Lys Ile Arg Ala Leu Leu Arg Leu Tyr Gln Glu Cys Glu Lys 
            260                 265                 270         


Leu Lys Lys Leu Met Ser Ser Asn Ser Thr Asp Leu Pro Leu Asn Ile 
        275                 280                 285             


Glu Cys Phe Met Asn Asp Lys Asp Val Ser Gly Lys Met Asn Arg Ser 
    290                 295                 300                 


Gln Phe Glu Glu Leu Cys Ala Glu Leu Leu Gln Lys Ile Glu Val Pro 
305                 310                 315                 320 


Leu Tyr Ser Leu Leu Glu Gln Thr His Leu Lys Val Glu Asp Val Ser 
                325                 330                 335     


Ala Val Glu Ile Val Gly Gly Ala Thr Arg Ile Pro Ala Val Lys Glu 
            340                 345                 350         


Arg Ile Ala Lys Phe Phe Gly Lys Asp Ile Ser Thr Thr Leu Asn Ala 
        355                 360                 365             


Asp Glu Ala Val Ala Arg Gly Cys Ala Leu Gln Cys Ala Ile Leu Ser 
    370                 375                 380                 


Pro Ala Phe Lys Val Arg Glu Phe Ser Val Thr Asp Ala Val Pro Phe 
385                 390                 395                 400 


Pro Ile Ser Leu Ile Trp Asn His Asp Ser Glu Asp Thr Glu Gly Val 
                405                 410                 415     


His Glu Val Phe Ser Arg Asn His Ala Ala Pro Phe Ser Lys Val Leu 
            420                 425                 430         


Thr Phe Leu Arg Arg Gly Pro Phe Glu Leu Glu Ala Phe Tyr Ser Asp 
        435                 440                 445             


Pro Gln Gly Val Pro Tyr Pro Glu Ala Lys Ile Gly Arg Phe Val Val 
    450                 455                 460                 


Gln Asn Val Ser Ala Gln Lys Asp Gly Glu Lys Ser Arg Val Lys Val 
465                 470                 475                 480 


Lys Val Arg Val Asn Thr His Gly Ile Phe Thr Ile Ser Thr Ala Ser 
                485                 490                 495     


Met Val Glu Lys Val Pro Thr Glu Glu Asn Glu Met Ser Ser Glu Ala 
            500                 505                 510         


Asp Met Glu Cys Leu Asn Gln Arg Pro Pro Glu Asn Pro Asp Thr Asp 
        515                 520                 525             


Lys Asn Val Gln Gln Asp Asn Ser Glu Ala Gly Thr Gln Pro Gln Val 
    530                 535                 540                 


Gln Thr Asp Ala Gln Gln Thr Ser Gln Ser Pro Pro Ser Pro Glu Leu 
545                 550                 555                 560 


Thr Ser Glu Glu Asn Lys Ile Pro Asp Ala Asp Lys Ala Asn Glu Lys 
                565                 570                 575     


Lys Val Asp Gln Pro Pro Glu Ala Lys Lys Pro Lys Ile Lys Val Val 
            580                 585                 590         


Asn Val Glu Leu Pro Ile Glu Ala Asn Leu Val Trp Gln Leu Gly Lys 
        595                 600                 605             


Asp Leu Leu Asn Met Tyr Ile Glu Thr Glu Gly Lys Met Ile Met Gln 
    610                 615                 620                 


Asp Lys Leu Glu Lys Glu Arg Asn Asp Ala Lys Asn Ala Val Glu Glu 
625                 630                 635                 640 


Tyr Val Tyr Glu Phe Arg Asp Lys Leu Cys Gly Pro Tyr Glu Lys Phe 
                645                 650                 655     


Ile Cys Glu Gln Asp His Gln Asn Phe Leu Arg Leu Leu Thr Glu Thr 
            660                 665                 670         


Glu Asp Trp Leu Tyr Glu Glu Gly Glu Asp Gln Ala Lys Gln Ala Tyr 
        675                 680                 685             


Val Asp Lys Leu Glu Glu Leu Met Lys Ile Gly Thr Pro Val Lys Val 
    690                 695                 700                 


Arg Phe Gln Glu Ala Glu Glu Arg Pro Lys Met Phe Glu Glu Leu Gly 
705                 710                 715                 720 


Gln Arg Leu Gln His Tyr Ala Lys Ile Ala Ala Asp Phe Arg Asn Lys 
                725                 730                 735     


Asp Glu Lys Tyr Asn His Ile Asp Glu Ser Glu Met Lys Lys Val Glu 
            740                 745                 750         


Lys Ser Val Asn Glu Val Met Glu Trp Met Asn Asn Val Met Asn Ala 
        755                 760                 765             


Gln Ala Lys Lys Ser Leu Asp Gln Asp Pro Val Val Arg Ala Gln Glu 
    770                 775                 780                 


Ile Lys Thr Lys Ile Lys Glu Leu Asn Asn Thr Cys Glu Pro Val Val 
785                 790                 795                 800 


Thr Gln Pro Lys Pro Lys Ile Glu Ser Pro Lys Leu Glu Arg Thr Pro 
                805                 810                 815     


Asn Gly Pro Asn Ile Asp Lys Lys Glu Glu Asp Leu Glu Asp Lys Asn 
            820                 825                 830         


Asn Phe Gly Ala Glu Pro Pro His Gln Asn Gly Glu Cys Tyr Pro Asn 
        835                 840                 845             


Glu Lys Asn Ser Val Asn Met Asp Leu Asp 
    850                 855             


<210>  366
<211>  434
<212>  PRT
<213>  Homo sapiens

<400>  366

Met Ala Met Gln Lys Ile Phe Ala Arg Glu Ile Leu Asp Ser Arg Gly 
1               5                   10                  15      


Asn Pro Thr Val Glu Val Asp Leu His Thr Ala Lys Gly Arg Phe Arg 
            20                  25                  30          


Ala Ala Val Pro Ser Gly Ala Ser Thr Gly Ile Tyr Glu Ala Leu Glu 
        35                  40                  45              


Leu Arg Asp Gly Asp Lys Gly Arg Tyr Leu Gly Lys Gly Val Leu Lys 
    50                  55                  60                  


Ala Val Glu Asn Ile Asn Ser Thr Leu Gly Pro Ala Leu Leu Gln Lys 
65                  70                  75                  80  


Lys Leu Ser Val Ala Asp Gln Glu Lys Val Asp Lys Phe Met Ile Glu 
                85                  90                  95      


Leu Asp Gly Thr Glu Asn Lys Ser Lys Phe Gly Ala Asn Ala Ile Leu 
            100                 105                 110         


Gly Val Ser Leu Ala Val Cys Lys Ala Gly Ala Ala Glu Lys Gly Val 
        115                 120                 125             


Pro Leu Tyr Arg His Ile Ala Asp Leu Ala Gly Asn Pro Asp Leu Ile 
    130                 135                 140                 


Leu Pro Val Pro Ala Phe Asn Val Ile Asn Gly Gly Ser His Ala Gly 
145                 150                 155                 160 


Asn Lys Leu Ala Met Gln Glu Phe Met Ile Leu Pro Val Gly Ala Ser 
                165                 170                 175     


Ser Phe Lys Glu Ala Met Arg Ile Gly Ala Glu Val Tyr His His Leu 
            180                 185                 190         


Lys Gly Val Ile Lys Ala Lys Tyr Gly Lys Asp Ala Thr Asn Val Gly 
        195                 200                 205             


Asp Glu Gly Gly Phe Ala Pro Asn Ile Leu Glu Asn Asn Glu Ala Leu 
    210                 215                 220                 


Glu Leu Leu Lys Thr Ala Ile Gln Ala Ala Gly Tyr Pro Asp Lys Val 
225                 230                 235                 240 


Val Ile Gly Met Asp Val Ala Ala Ser Glu Phe Tyr Arg Asn Gly Lys 
                245                 250                 255     


Tyr Asp Leu Asp Phe Lys Ser Pro Asp Asp Pro Ala Arg His Ile Thr 
            260                 265                 270         


Gly Glu Lys Leu Gly Glu Leu Tyr Lys Ser Phe Ile Lys Asn Tyr Pro 
        275                 280                 285             


Val Val Ser Ile Glu Asp Pro Phe Asp Gln Asp Asp Trp Ala Thr Trp 
    290                 295                 300                 


Thr Ser Phe Leu Ser Gly Val Asn Ile Gln Ile Val Gly Asp Asp Leu 
305                 310                 315                 320 


Thr Val Thr Asn Pro Lys Arg Ile Ala Gln Ala Val Glu Lys Lys Ala 
                325                 330                 335     


Cys Asn Cys Leu Leu Leu Lys Val Asn Gln Ile Gly Ser Val Thr Glu 
            340                 345                 350         


Ser Ile Gln Ala Cys Lys Leu Ala Gln Ser Asn Gly Trp Gly Val Met 
        355                 360                 365             


Val Ser His Arg Ser Gly Glu Thr Glu Asp Thr Phe Ile Ala Asp Leu 
    370                 375                 380                 


Val Val Gly Leu Cys Thr Gly Gln Ile Lys Thr Gly Ala Pro Cys Arg 
385                 390                 395                 400 


Ser Glu Arg Leu Ala Lys Tyr Asn Gln Leu Met Arg Ile Glu Glu Ala 
                405                 410                 415     


Leu Gly Asp Lys Ala Ile Phe Ala Gly Arg Lys Phe Arg Asn Pro Lys 
            420                 425                 430         


Ala Lys 
        


<210>  367
<211>  153
<212>  PRT
<213>  Homo sapiens

<400>  367

Met Asn Val Gly Thr Ala His Ser Glu Val Asn Pro Asn Thr Arg Val 
1               5                   10                  15      


Met Asn Ser Arg Gly Ile Trp Leu Ser Tyr Val Leu Ala Ile Gly Leu 
            20                  25                  30          


Leu His Ile Val Leu Leu Ser Ile Pro Phe Val Ser Val Pro Val Val 
        35                  40                  45              


Trp Thr Leu Thr Asn Leu Ile His Asn Met Gly Met Tyr Ile Phe Leu 
    50                  55                  60                  


His Thr Val Lys Gly Thr Pro Phe Glu Thr Pro Asp Gln Gly Lys Ala 
65                  70                  75                  80  


Arg Leu Leu Thr His Trp Glu Gln Met Asp Tyr Gly Val Gln Phe Thr 
                85                  90                  95      


Ala Ser Arg Lys Phe Leu Thr Ile Thr Pro Ile Val Leu Tyr Phe Leu 
            100                 105                 110         


Thr Ser Phe Tyr Thr Lys Tyr Asp Gln Ile His Phe Val Leu Asn Thr 
        115                 120                 125             


Val Ser Leu Met Ser Val Leu Ile Pro Lys Leu Pro Gln Leu His Gly 
    130                 135                 140                 


Val Arg Ile Phe Gly Ile Asn Lys Tyr 
145                 150             


<210>  368
<211>  417
<212>  PRT
<213>  Homo sapiens

<400>  368

Met Ala Val Ser Leu Thr Ala Ala Glu Thr Leu Ala Leu Gln Gly Thr 
1               5                   10                  15      


Gln Gly Gln Glu Lys Met Met Met Met Gly Pro Lys Glu Glu Glu Gln 
            20                  25                  30          


Ser Cys Glu Tyr Glu Thr Arg Leu Pro Gly Asn His Ser Thr Ser Gln 
        35                  40                  45              


Glu Ile Phe Arg Gln Arg Phe Arg His Leu Arg Tyr Gln Glu Thr Pro 
    50                  55                  60                  


Gly Pro Arg Glu Ala Leu Ser Gln Leu Arg Val Leu Cys Cys Glu Trp 
65                  70                  75                  80  


Leu Arg Pro Glu Lys His Thr Lys Glu Gln Ile Leu Glu Phe Leu Val 
                85                  90                  95      


Leu Glu Gln Phe Leu Thr Ile Leu Pro Glu Glu Leu Gln Ser Trp Val 
            100                 105                 110         


Arg Gly His His Pro Lys Ser Gly Glu Glu Ala Val Thr Val Leu Glu 
        115                 120                 125             


Asp Leu Glu Lys Gly Leu Glu Pro Glu Pro Gln Val Pro Gly Pro Ala 
    130                 135                 140                 


His Gly Pro Ala Gln Glu Glu Pro Trp Glu Lys Lys Glu Ser Leu Gly 
145                 150                 155                 160 


Ala Ala Gln Glu Ala Leu Ser Ile Gln Leu Gln Pro Lys Glu Thr Gln 
                165                 170                 175     


Pro Phe Pro Lys Ser Glu Gln Val Tyr Leu His Phe Leu Ser Val Val 
            180                 185                 190         


Thr Glu Asp Gly Pro Glu Pro Lys Asp Lys Gly Ser Leu Pro Gln Pro 
        195                 200                 205             


Pro Ile Thr Glu Val Glu Ser Gln Val Phe Ser Glu Lys Leu Ala Thr 
    210                 215                 220                 


Asp Thr Ser Thr Phe Glu Ala Thr Ser Glu Gly Thr Leu Glu Leu Gln 
225                 230                 235                 240 


Gln Arg Asn Pro Lys Ala Glu Arg Leu Arg Trp Ser Pro Ala Gln Glu 
                245                 250                 255     


Glu Ser Phe Arg Gln Met Val Val Ile His Lys Glu Ile Pro Thr Gly 
            260                 265                 270         


Lys Lys Asp His Glu Cys Ser Glu Cys Gly Lys Thr Phe Ile Tyr Asn 
        275                 280                 285             


Ser His Leu Val Val His Gln Arg Val His Ser Gly Glu Lys Pro Tyr 
    290                 295                 300                 


Lys Cys Ser Asp Cys Gly Lys Thr Phe Lys Gln Ser Ser Asn Leu Gly 
305                 310                 315                 320 


Gln His Gln Arg Ile His Thr Gly Glu Lys Pro Phe Glu Cys Asn Glu 
                325                 330                 335     


Cys Gly Lys Ala Phe Arg Trp Gly Ala His Leu Val Gln His Gln Arg 
            340                 345                 350         


Ile His Ser Gly Glu Lys Pro Tyr Glu Cys Asn Glu Cys Gly Lys Ala 
        355                 360                 365             


Phe Ser Gln Ser Ser Tyr Leu Ser Gln His Arg Arg Ile His Ser Gly 
    370                 375                 380                 


Glu Lys Pro Phe Ile Cys Lys Glu Cys Gly Lys Ala Tyr Gly Trp Cys 
385                 390                 395                 400 


Ser Glu Leu Ile Arg His Arg Arg Val His Ala Arg Lys Glu Pro Ser 
                405                 410                 415     


His 
    


<210>  369
<211>  958
<212>  PRT
<213>  Homo sapiens

<400>  369

Met Ala Phe Arg Gly Pro Glu Pro Trp Val Ser Ala Ser Leu Leu Arg 
1               5                   10                  15      


Gln Arg Leu Lys Ala Glu Glu Lys Thr Leu Asp Leu Glu Phe Glu Val 
            20                  25                  30          


Leu Ser Val Gly Phe Asn Glu Ala Gly Arg Tyr Ala Leu Arg Leu Ser 
        35                  40                  45              


Ala Glu Asn Pro Leu Gln Val Gly Ser Gly Ala Gly Val Gln Leu Gln 
    50                  55                  60                  


Val Asn Asp Gly Asp Pro Phe Pro Ala Cys Ser Ala Ile Thr Asp Val 
65                  70                  75                  80  


Ile Glu Gln Gln Glu Pro Gly Gln Ser Leu Thr Leu Thr Arg Ser Lys 
                85                  90                  95      


Phe Ile Phe Thr Leu Pro Lys Gly Phe Cys Lys Asn Asp Gly Gln His 
            100                 105                 110         


Asp Ala Gln Leu His Val Glu Ala Leu Arg Leu Asp Glu Pro Leu Gly 
        115                 120                 125             


Arg Ala Ala Gln Arg Val Gly Glu Ala Ile Phe Pro Ile Tyr Pro Arg 
    130                 135                 140                 


Pro Asp Gln Pro Arg Met Asn Pro Lys Ala Gln Asp His Glu Asp Leu 
145                 150                 155                 160 


Tyr Arg Tyr Cys Gly Asn Leu Ala Leu Leu Arg Ala Ser Thr Asp Pro 
                165                 170                 175     


Thr Ala Arg His Cys Gly Ser Leu Ala Tyr Ser Val Ala Phe His Val 
            180                 185                 190         


His Arg Gly Pro Gln Pro Pro Val Ser Asp Ser Pro Pro Arg Ala Gly 
        195                 200                 205             


Gln Pro Glu Leu Met Ser Pro Glu Glu Pro Leu Ile Ala Ser Gln Ser 
    210                 215                 220                 


Thr Glu Pro Glu Ile Gly His Leu Ser Pro Ser Lys Lys Glu Thr Ile 
225                 230                 235                 240 


Met Val Thr Leu His Gly Ala Thr Asn Leu Pro Ala Cys Lys Asp Gly 
                245                 250                 255     


Ser Glu Pro Trp Pro Tyr Val Val Val Lys Ser Thr Ser Glu Glu Lys 
            260                 265                 270         


Asn Asn Gln Ser Ser Lys Ala Val Thr Ser Val Thr Ser Glu Pro Thr 
        275                 280                 285             


Arg Ala Pro Ile Trp Gly Asp Thr Val Asn Val Glu Ile Gln Ala Glu 
    290                 295                 300                 


Asp Ala Gly Gln Glu Asp Val Ile Leu Lys Val Val Asp Asn Arg Lys 
305                 310                 315                 320 


Lys Gln Glu Leu Leu Ser Tyr Lys Ile Pro Ile Lys Tyr Leu Arg Val 
                325                 330                 335     


Phe His Pro Tyr His Phe Glu Leu Val Lys Pro Thr Glu Ser Gly Lys 
            340                 345                 350         


Ala Asp Glu Ala Thr Ala Lys Thr Gln Leu Tyr Ala Thr Val Val Arg 
        355                 360                 365             


Lys Ser Ser Phe Ile Pro Arg Tyr Ile Gly Cys Asn His Met Ala Leu 
    370                 375                 380                 


Glu Ile Phe Leu Arg Gly Val Asn Glu Pro Leu Ala Asn Asn Pro Asn 
385                 390                 395                 400 


Pro Ile Val Val Ile Ala Arg Val Val Pro Asn Tyr Lys Glu Phe Lys 
                405                 410                 415     


Val Ser Gln Ala Asn Arg Asp Leu Ala Ser Val Gly Leu Pro Ile Thr 
            420                 425                 430         


Pro Leu Ser Phe Pro Ile Pro Ser Met Met Asn Phe Asp Val Pro Arg 
        435                 440                 445             


Val Ser Gln Asn Gly Cys Pro Gln Leu Ser Lys Pro Gly Gly Pro Pro 
    450                 455                 460                 


Glu Gln Pro Leu Trp Asn Gln Ser Phe Leu Phe Gln Gly Arg Asp Gly 
465                 470                 475                 480 


Ala Thr Ser Phe Ser Glu Asp Thr Ala Leu Val Leu Glu Tyr Tyr Ser 
                485                 490                 495     


Ser Thr Ser Met Lys Gly Ser Gln Pro Trp Thr Leu Asn Gln Pro Leu 
            500                 505                 510         


Gly Ile Ser Val Leu Pro Leu Lys Ser Arg Leu Tyr Gln Lys Met Leu 
        515                 520                 525             


Thr Gly Lys Gly Leu Asp Gly Leu His Val Glu Arg Leu Pro Ile Met 
    530                 535                 540                 


Asp Thr Ser Leu Lys Thr Ile Asn Asp Glu Ala Pro Thr Val Ala Leu 
545                 550                 555                 560 


Ser Phe Gln Leu Leu Ser Ser Glu Arg Pro Glu Asn Phe Leu Thr Pro 
                565                 570                 575     


Asn Asn Ser Lys Ala Leu Pro Thr Leu Asp Pro Lys Ile Leu Asp Lys 
            580                 585                 590         


Lys Leu Arg Thr Ile Gln Glu Ser Trp Ser Lys Asp Thr Val Ser Ser 
        595                 600                 605             


Thr Met Asp Leu Ser Thr Ser Thr Pro Arg Glu Ala Glu Glu Glu Pro 
    610                 615                 620                 


Leu Val Pro Glu Met Ser His Asp Thr Glu Met Asn Asn Tyr Arg Arg 
625                 630                 635                 640 


Ala Met Gln Lys Met Ala Glu Asp Ile Leu Ser Leu Arg Arg Gln Ala 
                645                 650                 655     


Ser Ile Leu Glu Gly Glu Asn Arg Ile Leu Arg Ser Arg Leu Ala Gln 
            660                 665                 670         


Gln Glu Glu Glu Glu Gly Gln Gly Lys Ala Ser Glu Ala Gln Asn Thr 
        675                 680                 685             


Val Ser Met Lys Gln Lys Leu Leu Leu Ser Glu Leu Asp Met Lys Lys 
    690                 695                 700                 


Leu Arg Asp Arg Val Gln His Leu Gln Asn Glu Leu Ile Arg Lys Asn 
705                 710                 715                 720 


Asp Arg Glu Lys Glu Leu Leu Leu Leu Tyr Gln Ala Gln Gln Pro Gln 
                725                 730                 735     


Ala Ala Leu Leu Lys Gln Tyr Gln Gly Lys Leu Gln Lys Met Lys Ala 
            740                 745                 750         


Leu Glu Glu Thr Val Arg His Gln Glu Lys Val Ile Glu Lys Met Glu 
        755                 760                 765             


Arg Val Leu Glu Asp Arg Leu Gln Asp Arg Ser Lys Pro Pro Pro Leu 
    770                 775                 780                 


Asn Arg Gln Gln Gly Lys Pro Tyr Thr Gly Phe Pro Met Leu Ser Ala 
785                 790                 795                 800 


Ser Gly Leu Pro Leu Gly Ser Met Gly Glu Asn Leu Pro Val Glu Leu 
                805                 810                 815     


Tyr Ser Val Leu Leu Ala Glu Asn Ala Lys Leu Arg Thr Glu Leu Asp 
            820                 825                 830         


Lys Asn Arg His Gln Gln Ala Pro Ile Ile Leu Gln Gln Gln Ala Leu 
        835                 840                 845             


Pro Asp Leu Leu Ser Gly Thr Ser Asp Lys Phe Asn Leu Leu Ala Lys 
    850                 855                 860                 


Leu Glu His Ala Gln Ser Arg Ile Leu Ser Leu Glu Ser Gln Leu Glu 
865                 870                 875                 880 


Asp Ser Ala Arg Arg Trp Gly Arg Glu Lys Gln Asp Leu Ala Thr Arg 
                885                 890                 895     


Leu Gln Glu Gln Glu Lys Gly Phe Arg His Pro Ser Asn Ser Ile Ile 
            900                 905                 910         


Ile Glu Gln Pro Ser Ala Leu Thr His Ser Met Asp Leu Lys Gln Pro 
        915                 920                 925             


Ser Glu Leu Glu Pro Leu Leu Pro Ser Ser Asp Ser Lys Leu Asn Lys 
    930                 935                 940                 


Pro Leu Ser Pro Gln Lys Glu Thr Ala Asn Ser Gln Gln Thr 
945                 950                 955             


<210>  370
<211>  219
<212>  PRT
<213>  Homo sapiens

<400>  370

Met Ala Glu Ser Leu Arg Ser Pro Arg Arg Ser Leu Tyr Lys Leu Val 
1               5                   10                  15      


Gly Ser Pro Pro Trp Lys Glu Ala Phe Arg Gln Arg Cys Leu Glu Arg 
            20                  25                  30          


Met Arg Asn Ser Arg Asp Arg Leu Leu Asn Arg Tyr Arg Gln Ala Gly 
        35                  40                  45              


Ser Ser Gly Pro Gly Asn Ser Gln Asn Ser Phe Leu Val Gln Glu Val 
    50                  55                  60                  


Met Glu Glu Glu Trp Asn Ala Leu Gln Ser Val Glu Asn Cys Pro Glu 
65                  70                  75                  80  


Asp Leu Ala Gln Leu Glu Glu Leu Ile Asp Met Ala Val Leu Glu Glu 
                85                  90                  95      


Ile Gln Gln Glu Leu Ile Lys Gln Glu Gln Ser Ile Ile Ser Glu Tyr 
            100                 105                 110         


Glu Lys Ser Leu Gln Phe Asp Glu Lys Cys Leu Ser Ile Met Leu Ala 
        115                 120                 125             


Glu Trp Glu Ala Asn Pro Leu Ile Cys Pro Val Cys Thr Lys Tyr Asn 
    130                 135                 140                 


Leu Arg Ile Thr Ser Gly Val Val Val Cys Gln Cys Gly Leu Ser Ile 
145                 150                 155                 160 


Pro Ser His Ser Ser Glu Leu Thr Glu Gln Lys Leu Arg Ala Cys Leu 
                165                 170                 175     


Glu Gly Ser Ile Asn Glu His Ser Ala His Cys Pro His Thr Pro Glu 
            180                 185                 190         


Phe Ser Val Thr Gly Gly Thr Glu Glu Lys Ser Ser Leu Leu Met Ser 
        195                 200                 205             


Cys Leu Ala Cys Asp Thr Trp Ala Val Ile Leu 
    210                 215                 


<210>  371
<211>  365
<212>  PRT
<213>  Homo sapiens

<400>  371

Met Asn Ile Met Asp Phe Asn Val Lys Lys Leu Ala Ala Asp Ala Gly 
1               5                   10                  15      


Thr Phe Leu Ser Arg Ala Val Gln Phe Thr Glu Glu Lys Leu Gly Gln 
            20                  25                  30          


Ala Glu Lys Thr Glu Leu Asp Ala His Leu Glu Asn Leu Leu Ser Lys 
        35                  40                  45              


Ala Glu Cys Thr Lys Ile Trp Thr Glu Lys Ile Met Lys Gln Thr Glu 
    50                  55                  60                  


Val Leu Leu Gln Pro Asn Pro Asn Ala Arg Ile Glu Glu Phe Val Tyr 
65                  70                  75                  80  


Glu Lys Leu Asp Arg Lys Ala Pro Ser Arg Ile Asn Asn Pro Glu Leu 
                85                  90                  95      


Leu Gly Gln Tyr Met Ile Asp Ala Gly Thr Glu Phe Gly Pro Gly Thr 
            100                 105                 110         


Ala Tyr Gly Asn Ala Leu Ile Lys Cys Gly Glu Thr Gln Lys Arg Ile 
        115                 120                 125             


Gly Thr Ala Asp Arg Glu Leu Ile Gln Thr Ser Ala Leu Asn Phe Leu 
    130                 135                 140                 


Thr Pro Leu Arg Asn Phe Ile Glu Gly Asp Tyr Lys Thr Ile Ala Lys 
145                 150                 155                 160 


Glu Arg Lys Leu Leu Gln Asn Lys Arg Leu Asp Leu Asp Ala Ala Lys 
                165                 170                 175     


Thr Arg Leu Lys Lys Ala Lys Ala Ala Glu Thr Arg Asn Ser Ser Glu 
            180                 185                 190         


Gln Glu Leu Arg Ile Thr Gln Ser Glu Phe Asp Arg Gln Ala Glu Ile 
        195                 200                 205             


Thr Arg Leu Leu Leu Glu Gly Ile Ser Ser Thr His Ala His His Leu 
    210                 215                 220                 


Arg Cys Leu Asn Asp Phe Val Glu Ala Gln Met Thr Tyr Tyr Ala Gln 
225                 230                 235                 240 


Cys Tyr Gln Tyr Met Leu Asp Leu Gln Lys Gln Leu Gly Ser Phe Pro 
                245                 250                 255     


Ser Asn Tyr Leu Ser Asn Asn Asn Gln Thr Ser Val Thr Pro Val Pro 
            260                 265                 270         


Ser Val Leu Pro Asn Ala Ile Gly Ser Ser Ala Met Ala Ser Thr Ser 
        275                 280                 285             


Gly Leu Val Ile Thr Ser Pro Ser Asn Leu Ser Asp Leu Lys Glu Cys 
    290                 295                 300                 


Ser Gly Ser Arg Lys Ala Arg Val Leu Tyr Asp Tyr Asp Ala Ala Asn 
305                 310                 315                 320 


Ser Thr Glu Leu Ser Leu Leu Ala Asp Glu Val Ile Thr Val Phe Ser 
                325                 330                 335     


Val Val Gly Met Asp Ser Asp Trp Leu Met Gly Glu Arg Gly Asn Gln 
            340                 345                 350         


Lys Gly Lys Val Pro Ile Thr Tyr Leu Glu Leu Leu Asn 
        355                 360                 365 


<210>  372
<211>  256
<212>  PRT
<213>  Homo sapiens

<400>  372

Met Pro Leu His Lys Tyr Pro Val Trp Leu Trp Lys Arg Leu Gln Leu 
1               5                   10                  15      


Arg Glu Gly Ile Cys Ser Arg Leu Pro Gly His Tyr Leu Arg Ser Leu 
            20                  25                  30          


Glu Glu Glu Arg Thr Pro Thr Pro Val His Tyr Arg Pro His Gly Ala 
        35                  40                  45              


Lys Phe Lys Ile Asn Pro Lys Asn Gly Gln Arg Glu Arg Val Glu Asp 
    50                  55                  60                  


Val Pro Ile Pro Ile Tyr Phe Pro Pro Glu Ser Gln Arg Gly Leu Trp 
65                  70                  75                  80  


Gly Gly Glu Gly Trp Ile Leu Gly Gln Ile Tyr Ala Asn Asn Asp Lys 
                85                  90                  95      


Leu Ser Lys Arg Leu Lys Lys Val Trp Lys Pro Gln Leu Phe Glu Arg 
            100                 105                 110         


Glu Phe Tyr Ser Glu Ile Leu Asp Lys Lys Phe Thr Val Thr Val Thr 
        115                 120                 125             


Met Arg Thr Leu Asp Leu Ile Asp Glu Ala Tyr Gly Leu Asp Phe Tyr 
    130                 135                 140                 


Ile Leu Lys Thr Pro Lys Glu Asp Leu Cys Ser Lys Phe Gly Met Asp 
145                 150                 155                 160 


Leu Lys Arg Gly Met Leu Leu Arg Leu Ala Arg Gln Asp Pro Gln Leu 
                165                 170                 175     


His Pro Glu Asp Pro Glu Arg Arg Ala Ala Ile Tyr Asp Lys Tyr Lys 
            180                 185                 190         


Glu Phe Ala Ile Pro Glu Glu Glu Ala Glu Trp Val Gly Leu Thr Leu 
        195                 200                 205             


Glu Glu Ala Ile Glu Lys Gln Arg Leu Leu Glu Glu Lys Asp Pro Val 
    210                 215                 220                 


Pro Leu Phe Lys Ile Tyr Val Ala Glu Leu Ile Gln Gln Leu Gln Gln 
225                 230                 235                 240 


Gln Ala Leu Ser Glu Pro Ala Val Val Gln Lys Arg Ala Ser Gly Gln 
                245                 250                 255     


<210>  373
<211>  184
<212>  PRT
<213>  Homo sapiens

<400>  373

Met Ala Glu Pro Gln Pro Pro Ser Gly Gly Leu Thr Asp Glu Ala Ala 
1               5                   10                  15      


Leu Ser Cys Cys Ser Asp Ala Asp Pro Ser Thr Lys Asp Phe Leu Leu 
            20                  25                  30          


Gln Gln Thr Met Leu Arg Val Lys Asp Pro Lys Lys Ser Leu Asp Phe 
        35                  40                  45              


Tyr Thr Arg Val Leu Gly Met Thr Leu Ile Gln Lys Cys Asp Phe Pro 
    50                  55                  60                  


Ile Met Lys Phe Ser Leu Tyr Phe Leu Ala Tyr Glu Asp Lys Asn Asp 
65                  70                  75                  80  


Ile Pro Lys Glu Lys Asp Glu Lys Ile Ala Trp Ala Leu Ser Arg Lys 
                85                  90                  95      


Ala Thr Leu Glu Leu Thr His Asn Trp Gly Thr Glu Asp Asp Glu Thr 
            100                 105                 110         


Gln Ser Tyr His Asn Gly Asn Ser Asp Pro Arg Gly Phe Gly His Ile 
        115                 120                 125             


Gly Ile Ala Val Pro Asp Val Tyr Ser Ala Cys Lys Arg Phe Glu Glu 
    130                 135                 140                 


Leu Gly Val Lys Phe Val Lys Lys Pro Asp Asp Gly Lys Met Lys Gly 
145                 150                 155                 160 


Leu Ala Phe Ile Gln Asp Pro Asp Gly Tyr Trp Ile Glu Ile Leu Asn 
                165                 170                 175     


Pro Asn Lys Met Ala Thr Leu Met 
            180                 


<210>  374
<211>  184
<212>  PRT
<213>  Homo sapiens

<400>  374

Met Gly Asn Gly Met Asn Lys Ile Leu Pro Gly Leu Tyr Ile Gly Asn 
1               5                   10                  15      


Phe Lys Asp Ala Arg Asp Ala Glu Gln Leu Ser Lys Asn Lys Val Thr 
            20                  25                  30          


His Ile Leu Ser Val His Asp Ser Ala Arg Pro Met Leu Glu Gly Val 
        35                  40                  45              


Lys Tyr Leu Cys Ile Pro Ala Ala Asp Ser Pro Ser Gln Asn Leu Thr 
    50                  55                  60                  


Arg His Phe Lys Glu Ser Ile Lys Phe Ile His Glu Cys Arg Leu Arg 
65                  70                  75                  80  


Gly Glu Ser Cys Leu Val His Cys Leu Ala Gly Val Ser Arg Ser Val 
                85                  90                  95      


Thr Leu Val Ile Ala Tyr Ile Met Thr Val Thr Asp Phe Gly Trp Glu 
            100                 105                 110         


Asp Ala Leu His Thr Val Arg Ala Gly Arg Ser Cys Ala Asn Pro Asn 
        115                 120                 125             


Val Gly Phe Gln Arg Gln Leu Gln Glu Phe Glu Lys His Glu Val His 
    130                 135                 140                 


Gln Tyr Arg Gln Trp Leu Lys Glu Glu Tyr Gly Glu Ser Pro Leu Gln 
145                 150                 155                 160 


Asp Ala Glu Glu Ala Lys Asn Ile Leu Ala Ala Pro Gly Ile Leu Lys 
                165                 170                 175     


Phe Trp Ala Phe Leu Arg Arg Leu 
            180                 


<210>  375
<211>  254
<212>  PRT
<213>  Homo sapiens

<400>  375

Met Pro Ala Lys Thr Pro Ile Tyr Leu Lys Ala Ala Asn Asn Lys Lys 
1               5                   10                  15      


Gly Lys Lys Phe Lys Leu Arg Asp Ile Leu Ser Pro Asp Met Ile Ser 
            20                  25                  30          


Pro Pro Leu Gly Asp Phe Arg His Thr Ile His Ile Gly Lys Glu Gly 
        35                  40                  45              


Gln His Asp Val Phe Gly Asp Ile Ser Phe Leu Gln Gly Asn Tyr Glu 
    50                  55                  60                  


Leu Leu Pro Gly Asn Gln Glu Lys Ala His Leu Gly Gln Phe Pro Gly 
65                  70                  75                  80  


His Asn Glu Phe Phe Arg Ala Asn Ser Thr Ser Asp Ser Val Phe Thr 
                85                  90                  95      


Glu Thr Pro Ser Pro Val Leu Lys Asn Ala Ile Ser Leu Pro Thr Ile 
            100                 105                 110         


Gly Gly Ser Gln Ala Leu Met Leu Pro Leu Leu Ser Pro Val Thr Phe 
        115                 120                 125             


Asn Ser Lys Gln Glu Ser Phe Gly Pro Ala Lys Leu Pro Arg Leu Ser 
    130                 135                 140                 


Cys Glu Pro Val Met Glu Glu Lys Ala Gln Glu Lys Ser Ser Leu Leu 
145                 150                 155                 160 


Glu Asn Gly Thr Val His Gln Gly Asp Thr Ser Trp Gly Ser Ser Gly 
                165                 170                 175     


Ser Ala Ser Gln Ser Ser Gln Gly Arg Asp Ser His Ser Ser Ser Leu 
            180                 185                 190         


Ser Glu Gln Tyr Pro Asp Trp Pro Ala Glu Asp Met Phe Asp His Pro 
        195                 200                 205             


Thr Pro Cys Glu Leu Ile Lys Gly Lys Thr Lys Ser Glu Glu Ser Leu 
    210                 215                 220                 


Ser Asp Leu Thr Gly Ser Leu Leu Ser Leu Gln Leu Asp Leu Gly Pro 
225                 230                 235                 240 


Ser Leu Leu Asp Glu Val Leu Asn Val Met Asp Lys Asn Lys 
                245                 250                 


<210>  376
<211>  402
<212>  PRT
<213>  Homo sapiens

<400>  376

Met Asn Ile His Met Lys Arg Lys Thr Ile Lys Asn Ile Asn Thr Phe 
1               5                   10                  15      


Glu Asn Arg Met Leu Met Leu Asp Gly Met Pro Ala Val Arg Val Lys 
            20                  25                  30          


Thr Glu Leu Leu Glu Ser Glu Gln Gly Ser Pro Asn Val His Asn Tyr 
        35                  40                  45              


Pro Asp Met Glu Ala Val Pro Leu Leu Leu Asn Asn Val Lys Gly Glu 
    50                  55                  60                  


Pro Pro Glu Asp Ser Leu Ser Val Asp His Phe Gln Thr Gln Thr Glu 
65                  70                  75                  80  


Pro Val Asp Leu Ser Ile Asn Lys Ala Arg Thr Ser Pro Thr Ala Val 
                85                  90                  95      


Ser Ser Ser Pro Val Ser Met Thr Ala Ser Ala Ser Ser Pro Ser Ser 
            100                 105                 110         


Thr Ser Thr Ser Ser Ser Ser Ser Ser Arg Leu Ala Ser Ser Pro Thr 
        115                 120                 125             


Val Ile Thr Ser Val Ser Ser Ala Ser Ser Ser Ser Thr Val Leu Thr 
    130                 135                 140                 


Pro Gly Pro Leu Val Ala Ser Ala Ser Gly Val Gly Gly Gln Gln Phe 
145                 150                 155                 160 


Leu His Ile Ile His Pro Val Pro Pro Ser Ser Pro Met Asn Leu Gln 
                165                 170                 175     


Ser Asn Lys Leu Ser His Val His Arg Ile Pro Val Val Val Gln Ser 
            180                 185                 190         


Val Pro Val Val Tyr Thr Ala Val Arg Ser Pro Gly Asn Val Asn Asn 
        195                 200                 205             


Thr Ile Val Val Pro Leu Leu Glu Asp Gly Arg Gly His Gly Lys Ala 
    210                 215                 220                 


Gln Met Asp Pro Arg Gly Leu Ser Pro Arg Gln Ser Lys Ser Asp Ser 
225                 230                 235                 240 


Asp Asp Asp Asp Leu Pro Asn Val Thr Leu Asp Ser Val Asn Glu Thr 
                245                 250                 255     


Gly Ser Thr Ala Leu Ser Ile Ala Arg Ala Val Gln Glu Val His Pro 
            260                 265                 270         


Ser Pro Val Ser Arg Val Arg Gly Asn Arg Met Asn Asn Gln Lys Phe 
        275                 280                 285             


Pro Cys Ser Ile Ser Pro Phe Ser Ile Glu Ser Thr Arg Arg Gln Arg 
    290                 295                 300                 


Arg Ser Glu Ser Pro Asp Ser Arg Lys Arg Arg Ile His Arg Cys Asp 
305                 310                 315                 320 


Phe Glu Gly Cys Asn Lys Val Tyr Thr Lys Ser Ser His Leu Lys Ala 
                325                 330                 335     


His Arg Arg Thr His Thr Gly Glu Lys Pro Tyr Lys Cys Thr Trp Glu 
            340                 345                 350         


Gly Cys Thr Trp Lys Phe Ala Arg Ser Asp Glu Leu Thr Arg His Tyr 
        355                 360                 365             


Arg Lys His Thr Gly Val Lys Pro Phe Lys Cys Ala Asp Cys Asp Arg 
    370                 375                 380                 


Ser Phe Ser Arg Ser Asp His Leu Ala Leu His Arg Arg Arg His Met 
385                 390                 395                 400 


Leu Val 
        


<210>  377
<211>  98
<212>  PRT
<213>  Homo sapiens

<400>  377

Met Ala Leu Leu Leu Ala Leu Ser Leu Leu Val Leu Trp Thr Ser Pro 
1               5                   10                  15      


Ala Pro Thr Leu Ser Gly Thr Asn Asp Ala Glu Asp Cys Cys Leu Ser 
            20                  25                  30          


Val Thr Gln Lys Pro Ile Pro Gly Tyr Ile Val Arg Asn Phe His Tyr 
        35                  40                  45              


Leu Leu Ile Lys Asp Gly Cys Arg Val Pro Ala Val Val Phe Thr Thr 
    50                  55                  60                  


Leu Arg Gly Arg Gln Leu Cys Ala Pro Pro Asp Gln Pro Trp Val Glu 
65                  70                  75                  80  


Arg Ile Ile Gln Arg Leu Gln Arg Thr Ser Ala Lys Met Lys Arg Arg 
                85                  90                  95      


Ser Ser 
        


<210>  378
<211>  101
<212>  PRT
<213>  Homo sapiens

<400>  378

Met Glu Arg Pro Asp Lys Ala Ala Leu Asn Ala Leu Gln Pro Pro Glu 
1               5                   10                  15      


Phe Arg Asn Glu Ser Ser Leu Ala Ser Thr Leu Lys Thr Leu Leu Phe 
            20                  25                  30          


Phe Thr Ala Leu Met Ile Thr Val Pro Ile Gly Leu Tyr Phe Thr Thr 
        35                  40                  45              


Lys Ser Tyr Ile Phe Glu Gly Ala Leu Gly Met Ser Asn Arg Asp Ser 
    50                  55                  60                  


Tyr Phe Tyr Ala Ala Ile Val Ala Val Val Ala Val His Val Val Leu 
65                  70                  75                  80  


Ala Leu Phe Val Tyr Val Ala Trp Asn Glu Gly Ser Arg Gln Trp Arg 
                85                  90                  95      


Glu Gly Lys Gln Asp 
            100     


<210>  379
<211>  189
<212>  PRT
<213>  Homo sapiens

<400>  379

Met Thr Glu Tyr Lys Leu Val Val Val Gly Ala Gly Gly Val Gly Lys 
1               5                   10                  15      


Ser Ala Leu Thr Ile Gln Leu Ile Gln Asn His Phe Val Asp Glu Tyr 
            20                  25                  30          


Asp Pro Thr Ile Glu Asp Ser Tyr Arg Lys Gln Val Val Ile Asp Gly 
        35                  40                  45              


Glu Thr Cys Leu Leu Asp Ile Leu Asp Thr Ala Gly Gln Glu Glu Tyr 
    50                  55                  60                  


Ser Ala Met Arg Asp Gln Tyr Met Arg Thr Gly Glu Gly Phe Leu Cys 
65                  70                  75                  80  


Val Phe Ala Ile Asn Asn Thr Lys Ser Phe Glu Asp Ile His Gln Tyr 
                85                  90                  95      


Arg Glu Gln Ile Lys Arg Val Lys Asp Ser Asp Asp Val Pro Met Val 
            100                 105                 110         


Leu Val Gly Asn Lys Cys Asp Leu Ala Ala Arg Thr Val Glu Ser Arg 
        115                 120                 125             


Gln Ala Gln Asp Leu Ala Arg Ser Tyr Gly Ile Pro Tyr Ile Glu Thr 
    130                 135                 140                 


Ser Ala Lys Thr Arg Gln Gly Val Glu Asp Ala Phe Tyr Thr Leu Val 
145                 150                 155                 160 


Arg Glu Ile Arg Gln His Lys Leu Arg Lys Leu Asn Pro Pro Asp Glu 
                165                 170                 175     


Ser Gly Pro Gly Cys Met Ser Cys Lys Cys Val Leu Ser 
            180                 185                 


<210>  380
<211>  118
<212>  PRT
<213>  Homo sapiens

<400>  380

Met Ala Ser Gln Ser Gln Gly Ile Gln Gln Leu Leu Gln Ala Glu Lys 
1               5                   10                  15      


Arg Ala Ala Glu Lys Val Ser Glu Ala Arg Lys Arg Lys Asn Arg Arg 
            20                  25                  30          


Leu Lys Gln Ala Lys Glu Glu Ala Gln Ala Glu Ile Glu Gln Tyr Arg 
        35                  40                  45              


Leu Gln Arg Glu Lys Glu Phe Lys Ala Lys Glu Ala Ala Ala Leu Gly 
    50                  55                  60                  


Ser Arg Gly Ser Cys Ser Thr Glu Val Glu Lys Glu Thr Gln Glu Lys 
65                  70                  75                  80  


Met Thr Ile Leu Gln Thr Tyr Phe Arg Gln Asn Arg Asp Glu Val Leu 
                85                  90                  95      


Asp Asn Leu Leu Ala Phe Val Cys Asp Ile Arg Pro Glu Ile His Glu 
            100                 105                 110         


Asn Tyr Arg Ile Asn Gly 
        115             


<210>  381
<211>  1130
<212>  PRT
<213>  Homo sapiens

<400>  381

Met Leu Glu Ile Cys Leu Lys Leu Val Gly Cys Lys Ser Lys Lys Gly 
1               5                   10                  15      


Leu Ser Ser Ser Ser Ser Cys Tyr Leu Glu Glu Ala Leu Gln Arg Pro 
            20                  25                  30          


Val Ala Ser Asp Phe Glu Pro Gln Gly Leu Ser Glu Ala Ala Arg Trp 
        35                  40                  45              


Asn Ser Lys Glu Asn Leu Leu Ala Gly Pro Ser Glu Asn Asp Pro Asn 
    50                  55                  60                  


Leu Phe Val Ala Leu Tyr Asp Phe Val Ala Ser Gly Asp Asn Thr Leu 
65                  70                  75                  80  


Ser Ile Thr Lys Gly Glu Lys Leu Arg Val Leu Gly Tyr Asn His Asn 
                85                  90                  95      


Gly Glu Trp Cys Glu Ala Gln Thr Lys Asn Gly Gln Gly Trp Val Pro 
            100                 105                 110         


Ser Asn Tyr Ile Thr Pro Val Asn Ser Leu Glu Lys His Ser Trp Tyr 
        115                 120                 125             


His Gly Pro Val Ser Arg Asn Ala Ala Glu Tyr Leu Leu Ser Ser Gly 
    130                 135                 140                 


Ile Asn Gly Ser Phe Leu Val Arg Glu Ser Glu Ser Ser Pro Gly Gln 
145                 150                 155                 160 


Arg Ser Ile Ser Leu Arg Tyr Glu Gly Arg Val Tyr His Tyr Arg Ile 
                165                 170                 175     


Asn Thr Ala Ser Asp Gly Lys Leu Tyr Val Ser Ser Glu Ser Arg Phe 
            180                 185                 190         


Asn Thr Leu Ala Glu Leu Val His His His Ser Thr Val Ala Asp Gly 
        195                 200                 205             


Leu Ile Thr Thr Leu His Tyr Pro Ala Pro Lys Arg Asn Lys Pro Thr 
    210                 215                 220                 


Val Tyr Gly Val Ser Pro Asn Tyr Asp Lys Trp Glu Met Glu Arg Thr 
225                 230                 235                 240 


Asp Ile Thr Met Lys His Lys Leu Gly Gly Gly Gln Tyr Gly Glu Val 
                245                 250                 255     


Tyr Glu Gly Val Trp Lys Lys Tyr Ser Leu Thr Val Ala Val Lys Thr 
            260                 265                 270         


Leu Lys Glu Asp Thr Met Glu Val Glu Glu Phe Leu Lys Glu Ala Ala 
        275                 280                 285             


Val Met Lys Glu Ile Lys His Pro Asn Leu Val Gln Leu Leu Gly Val 
    290                 295                 300                 


Cys Thr Arg Glu Pro Pro Phe Tyr Ile Ile Thr Glu Phe Met Thr Tyr 
305                 310                 315                 320 


Gly Asn Leu Leu Asp Tyr Leu Arg Glu Cys Asn Arg Gln Glu Val Asn 
                325                 330                 335     


Ala Val Val Leu Leu Tyr Met Ala Thr Gln Ile Ser Ser Ala Met Glu 
            340                 345                 350         


Tyr Leu Glu Lys Lys Asn Phe Ile His Arg Asp Leu Ala Ala Arg Asn 
        355                 360                 365             


Cys Leu Val Gly Glu Asn His Leu Val Lys Val Ala Asp Phe Gly Leu 
    370                 375                 380                 


Ser Arg Leu Met Thr Gly Asp Thr Tyr Thr Ala His Ala Gly Ala Lys 
385                 390                 395                 400 


Phe Pro Ile Lys Trp Thr Ala Pro Glu Ser Leu Ala Tyr Asn Lys Phe 
                405                 410                 415     


Ser Ile Lys Ser Asp Val Trp Ala Phe Gly Val Leu Leu Trp Glu Ile 
            420                 425                 430         


Ala Thr Tyr Gly Met Ser Pro Tyr Pro Gly Ile Asp Leu Ser Gln Val 
        435                 440                 445             


Tyr Glu Leu Leu Glu Lys Asp Tyr Arg Met Glu Arg Pro Glu Gly Cys 
    450                 455                 460                 


Pro Glu Lys Val Tyr Glu Leu Met Arg Ala Cys Trp Gln Trp Asn Pro 
465                 470                 475                 480 


Ser Asp Arg Pro Ser Phe Ala Glu Ile His Gln Ala Phe Glu Thr Met 
                485                 490                 495     


Phe Gln Glu Ser Ser Ile Ser Asp Glu Val Glu Lys Glu Leu Gly Lys 
            500                 505                 510         


Gln Gly Val Arg Gly Ala Val Ser Thr Leu Leu Gln Ala Pro Glu Leu 
        515                 520                 525             


Pro Thr Lys Thr Arg Thr Ser Arg Arg Ala Ala Glu His Arg Asp Thr 
    530                 535                 540                 


Thr Asp Val Pro Glu Met Pro His Ser Lys Gly Gln Gly Glu Ser Asp 
545                 550                 555                 560 


Pro Leu Asp His Glu Pro Ala Val Ser Pro Leu Leu Pro Arg Lys Glu 
                565                 570                 575     


Arg Gly Pro Pro Glu Gly Gly Leu Asn Glu Asp Glu Arg Leu Leu Pro 
            580                 585                 590         


Lys Asp Lys Lys Thr Asn Leu Phe Ser Ala Leu Ile Lys Lys Lys Lys 
        595                 600                 605             


Lys Thr Ala Pro Thr Pro Pro Lys Arg Ser Ser Ser Phe Arg Glu Met 
    610                 615                 620                 


Asp Gly Gln Pro Glu Arg Arg Gly Ala Gly Glu Glu Glu Gly Arg Asp 
625                 630                 635                 640 


Ile Ser Asn Gly Ala Leu Ala Phe Thr Pro Leu Asp Thr Ala Asp Pro 
                645                 650                 655     


Ala Lys Ser Pro Lys Pro Ser Asn Gly Ala Gly Val Pro Asn Gly Ala 
            660                 665                 670         


Leu Arg Glu Ser Gly Gly Ser Gly Phe Arg Ser Pro His Leu Trp Lys 
        675                 680                 685             


Lys Ser Ser Thr Leu Thr Ser Ser Arg Leu Ala Thr Gly Glu Glu Glu 
    690                 695                 700                 


Gly Gly Gly Ser Ser Ser Lys Arg Phe Leu Arg Ser Cys Ser Ala Ser 
705                 710                 715                 720 


Cys Val Pro His Gly Ala Lys Asp Thr Glu Trp Arg Ser Val Thr Leu 
                725                 730                 735     


Pro Arg Asp Leu Gln Ser Thr Gly Arg Gln Phe Asp Ser Ser Thr Phe 
            740                 745                 750         


Gly Gly His Lys Ser Glu Lys Pro Ala Leu Pro Arg Lys Arg Ala Gly 
        755                 760                 765             


Glu Asn Arg Ser Asp Gln Val Thr Arg Gly Thr Val Thr Pro Pro Pro 
    770                 775                 780                 


Arg Leu Val Lys Lys Asn Glu Glu Ala Ala Asp Glu Val Phe Lys Asp 
785                 790                 795                 800 


Ile Met Glu Ser Ser Pro Gly Ser Ser Pro Pro Asn Leu Thr Pro Lys 
                805                 810                 815     


Pro Leu Arg Arg Gln Val Thr Val Ala Pro Ala Ser Gly Leu Pro His 
            820                 825                 830         


Lys Glu Glu Ala Gly Lys Gly Ser Ala Leu Gly Thr Pro Ala Ala Ala 
        835                 840                 845             


Glu Pro Val Thr Pro Thr Ser Lys Ala Gly Ser Gly Ala Pro Gly Gly 
    850                 855                 860                 


Thr Ser Lys Gly Pro Ala Glu Glu Ser Arg Val Arg Arg His Lys His 
865                 870                 875                 880 


Ser Ser Glu Ser Pro Gly Arg Asp Lys Gly Lys Leu Ser Arg Leu Lys 
                885                 890                 895     


Pro Ala Pro Pro Pro Pro Pro Ala Ala Ser Ala Gly Lys Ala Gly Gly 
            900                 905                 910         


Lys Pro Ser Gln Ser Pro Ser Gln Glu Ala Ala Gly Glu Ala Val Leu 
        915                 920                 925             


Gly Ala Lys Thr Lys Ala Thr Ser Leu Val Asp Ala Val Asn Ser Asp 
    930                 935                 940                 


Ala Ala Lys Pro Ser Gln Pro Gly Glu Gly Leu Lys Lys Pro Val Leu 
945                 950                 955                 960 


Pro Ala Thr Pro Lys Pro Gln Ser Ala Lys Pro Ser Gly Thr Pro Ile 
                965                 970                 975     


Ser Pro Ala Pro Val Pro Ser Thr Leu Pro Ser Ala Ser Ser Ala Leu 
            980                 985                 990         


Ala Gly Asp Gln Pro Ser Ser Thr  Ala Phe Ile Pro Leu  Ile Ser Thr 
        995                 1000                 1005             


Arg Val  Ser Leu Arg Lys Thr  Arg Gln Pro Pro Glu  Arg Ile Ala 
    1010                 1015                 1020             


Ser Gly  Ala Ile Thr Lys Gly  Val Val Leu Asp Ser  Thr Glu Ala 
    1025                 1030                 1035             


Leu Cys  Leu Ala Ile Ser Arg  Asn Ser Glu Gln Met  Ala Ser His 
    1040                 1045                 1050             


Ser Ala  Val Leu Glu Ala Gly  Lys Asn Leu Tyr Thr  Phe Cys Val 
    1055                 1060                 1065             


Ser Tyr  Val Asp Ser Ile Gln  Gln Met Arg Asn Lys  Phe Ala Phe 
    1070                 1075                 1080             


Arg Glu  Ala Ile Asn Lys Leu  Glu Asn Asn Leu Arg  Glu Leu Gln 
    1085                 1090                 1095             


Ile Cys  Pro Ala Thr Ala Gly  Ser Gly Pro Ala Ala  Thr Gln Asp 
    1100                 1105                 1110             


Phe Ser  Lys Leu Leu Ser Ser  Val Lys Glu Ile Ser  Asp Ile Val 
    1115                 1120                 1125             


Gln Arg  
    1130 


<210>  382
<211>  775
<212>  PRT
<213>  Homo sapiens

<400>  382

Met Glu Lys Phe Gly Met Asn Phe Gly Gly Gly Pro Ser Lys Lys Asp 
1               5                   10                  15      


Leu Leu Glu Thr Ile Glu Thr Gln Lys Lys Gln Leu Leu Gln Tyr Gln 
            20                  25                  30          


Ala Arg Leu Lys Asp Val Val Arg Ala Tyr Lys Ser Leu Leu Lys Glu 
        35                  40                  45              


Lys Glu Ala Leu Glu Ala Ser Ile Lys Val Leu Ser Val Ser His Glu 
    50                  55                  60                  


Ala Asp Val Gly Leu Ala Gly Val Gln Leu Pro Gly Leu Thr Phe Pro 
65                  70                  75                  80  


Asp Ser Val Asp Asp Arg Cys Ser Thr His Ser Glu Asp Ser Thr Gly 
                85                  90                  95      


Thr Ala Thr Ser Leu Asp Thr Ala Ala Ser Leu Thr Ser Thr Lys Gly 
            100                 105                 110         


Glu Phe Gly Val Glu Asp Asp Arg Pro Ala Arg Gly Pro Pro Pro Pro 
        115                 120                 125             


Lys Ser Glu Glu Ala Ser Trp Ser Glu Ser Gly Val Ser Ser Ser Ser 
    130                 135                 140                 


Gly Asp Gly Pro Phe Ala Gly Gly Glu Val Asp Lys Arg Leu His Gln 
145                 150                 155                 160 


Leu Lys Thr Gln Leu Ala Thr Leu Thr Ser Ser Leu Ala Thr Val Thr 
                165                 170                 175     


Gln Glu Lys Ser Arg Met Glu Ala Ser Tyr Leu Ala Asp Lys Lys Lys 
            180                 185                 190         


Met Lys Gln Asp Leu Glu Asp Ala Ser Asn Lys Ala Glu Glu Glu Arg 
        195                 200                 205             


Ala Arg Leu Glu Gly Glu Leu Lys Gly Leu Gln Glu Gln Ile Ala Glu 
    210                 215                 220                 


Thr Lys Ala Arg Leu Ile Thr Gln Gln His Asp Arg Ala Gln Glu Gln 
225                 230                 235                 240 


Ser Asp His Ala Leu Met Leu Arg Glu Leu Gln Lys Leu Leu Gln Glu 
                245                 250                 255     


Glu Arg Thr Gln Arg Gln Asp Leu Glu Leu Arg Leu Glu Glu Thr Arg 
            260                 265                 270         


Glu Ala Leu Ala Gly Arg Ala Tyr Ala Ala Glu Gln Met Glu Gly Phe 
        275                 280                 285             


Glu Leu Gln Thr Lys Gln Leu Thr Arg Glu Val Glu Glu Leu Lys Ser 
    290                 295                 300                 


Glu Leu Gln Ala Ile Arg Asp Glu Lys Asn Gln Pro Asp Pro Arg Leu 
305                 310                 315                 320 


Gln Glu Leu Gln Glu Glu Ala Ala Arg Leu Lys Ser His Phe Gln Ala 
                325                 330                 335     


Gln Leu Gln Gln Glu Met Arg Lys Thr Ala Leu Ala Glu Asp Gln Leu 
            340                 345                 350         


Arg Gln Gln Ser Gln Val Glu Glu Gln Arg Val Ala Ala Leu Glu Asn 
        355                 360                 365             


Gln Ile Ser Glu Val Ser Glu Leu Leu Gly Thr Tyr Glu Lys Ala Lys 
    370                 375                 380                 


Gln Lys Asp Gln Leu Ala Ile Gln Lys Leu Lys Glu Arg Ile Leu Gln 
385                 390                 395                 400 


Leu Asp Leu Glu Asn Lys Thr Leu Ala Leu Ala Ala Ser Ser Arg Ser 
                405                 410                 415     


Pro Leu Asp Ser His Gly Glu Glu Ser Ser Leu Asp Val Asn Val Leu 
            420                 425                 430         


Lys Asp Lys Met Glu Lys Leu Lys Arg Leu Leu Gln Val Ala Ala Arg 
        435                 440                 445             


Lys Ser Gln Val Thr Leu Asp Val Glu Lys Leu Cys Asp Leu Glu Ile 
    450                 455                 460                 


Met Pro Ser Ser Glu Ala Ala Asp Gly Glu Lys Ala Thr Ala Leu Tyr 
465                 470                 475                 480 


Tyr Gln Gln Glu Leu Lys Gln Leu Lys Glu Glu Phe Glu Arg Tyr Lys 
                485                 490                 495     


Met Arg Ala Gln Val Val Leu Lys Ser Lys Asn Thr Lys Asp Gly Asn 
            500                 505                 510         


Leu Gly Lys Glu Leu Glu Ala Ala Gln Glu Gln Leu Ala Glu Leu Lys 
        515                 520                 525             


Glu Lys Tyr Ile Ser Leu Arg Leu Ser Cys Glu Glu Leu Glu His Gln 
    530                 535                 540                 


His Gln Gln Glu Ala Asp Asp Trp Lys Gln Glu Leu Ala Arg Leu Gln 
545                 550                 555                 560 


Gln Leu His Arg Gln Glu Leu Glu Arg Cys Gln Leu Asp Phe Arg Asp 
                565                 570                 575     


Arg Thr Leu Lys Leu Glu Glu Glu Leu His Lys Gln Arg Asp Arg Ala 
            580                 585                 590         


Leu Ala Val Leu Thr Glu Lys Asp Leu Glu Leu Glu Gln Leu Arg Ser 
        595                 600                 605             


Val Ala Leu Ala Ser Gly Leu Pro Gly Arg Arg Ser Pro Val Gly Gly 
    610                 615                 620                 


Gly Gly Pro Gly Asp Pro Ala Asp Thr Ser Ser Ser Asp Ser Leu Thr 
625                 630                 635                 640 


Gln Ala Leu Gln Leu Ala Ala Ala Asn Glu Pro Thr Phe Phe Leu Tyr 
                645                 650                 655     


Ala Glu Gln Leu Ala Arg Lys Glu Val Glu Ile Thr Ser Leu Arg Lys 
            660                 665                 670         


Gln Lys His Arg Leu Glu Val Glu Val His Gln Leu Gln Asp Arg Leu 
        675                 680                 685             


Leu Glu Glu Gly Glu Arg His Arg Glu Glu Val Ala Ala Leu Gln Ser 
    690                 695                 700                 


His Ile Glu Lys Asn Ile Arg Asp Gln Ser Arg Glu Gly Ala Asn Leu 
705                 710                 715                 720 


Glu Tyr Leu Lys Asn Ile Ile Tyr Arg Phe Leu Thr Leu Pro Asp Ser 
                725                 730                 735     


Leu Gly Arg Gln Gln Thr Leu Thr Ala Ile Leu Thr Ile Leu His Phe 
            740                 745                 750         


Ser Pro Glu Glu Lys Gln Val Ile Met Arg Leu Pro Thr Ser Ala Ser 
        755                 760                 765             


Trp Trp Pro Ser Gly Lys Arg 
    770                 775 


<210>  383
<211>  279
<212>  PRT
<213>  Homo sapiens

<400>  383

Met Asp Phe Ser Pro Ser Ser Glu Leu Gly Phe His Phe Val Ala Phe 
1               5                   10                  15      


Ile Leu Leu Thr Arg His Arg Thr Ala Phe Pro Ala Ser Gly Lys Lys 
            20                  25                  30          


Arg Glu Thr Asp Tyr Ser Asp Gly Asp Pro Leu Asp Val His Lys Arg 
        35                  40                  45              


Leu Pro Ser Ser Ala Gly Glu Asp Arg Ala Val Met Leu Gly Phe Ala 
    50                  55                  60                  


Met Met Gly Phe Ser Val Leu Met Phe Phe Leu Leu Gly Thr Thr Ile 
65                  70                  75                  80  


Leu Lys Pro Phe Met Leu Ser Ile Gln Arg Glu Glu Ser Thr Cys Thr 
                85                  90                  95      


Ala Ile His Thr Asp Ile Met Asp Asp Trp Leu Asp Cys Ala Phe Thr 
            100                 105                 110         


Cys Gly Val His Cys His Gly Gln Gly Lys Tyr Pro Cys Leu Gln Val 
        115                 120                 125             


Phe Val Asn Leu Ser His Pro Gly Gln Lys Ala Leu Leu His Tyr Asn 
    130                 135                 140                 


Glu Glu Ala Val Gln Ile Asn Pro Lys Cys Phe Tyr Thr Pro Lys Cys 
145                 150                 155                 160 


His Gln Asp Arg Asn Asp Leu Leu Asn Ser Ala Leu Asp Ile Lys Glu 
                165                 170                 175     


Phe Phe Asp His Lys Asn Gly Thr Pro Phe Ser Cys Phe Tyr Ser Pro 
            180                 185                 190         


Ala Ser Gln Ser Glu Asp Val Ile Leu Ile Lys Lys Tyr Asp Gln Met 
        195                 200                 205             


Ala Ile Phe His Cys Leu Phe Trp Pro Ser Leu Thr Leu Leu Gly Gly 
    210                 215                 220                 


Ala Leu Ile Val Gly Met Val Arg Leu Thr Gln His Leu Ser Leu Leu 
225                 230                 235                 240 


Cys Glu Lys Tyr Ser Thr Val Val Arg Asp Glu Val Gly Gly Lys Val 
                245                 250                 255     


Pro Tyr Ile Glu Gln His Gln Phe Lys Leu Cys Ile Met Arg Arg Ser 
            260                 265                 270         


Lys Gly Arg Ala Glu Lys Ser 
        275                 


<210>  384
<211>  405
<212>  PRT
<213>  Homo sapiens

<400>  384

Met Glu Arg Leu Gln Lys Gln Pro Leu Thr Ser Pro Gly Ser Val Ser 
1               5                   10                  15      


Pro Ser Arg Asp Ser Ser Val Pro Gly Ser Pro Ser Ser Ile Val Ala 
            20                  25                  30          


Lys Met Asp Asn Gln Val Leu Gly Tyr Lys Asp Leu Ala Ala Ile Pro 
        35                  40                  45              


Lys Asp Lys Ala Ile Leu Asp Ile Glu Arg Pro Asp Leu Met Ile Tyr 
    50                  55                  60                  


Glu Pro His Phe Thr Tyr Ser Leu Leu Glu His Val Glu Leu Pro Arg 
65                  70                  75                  80  


Ser Arg Glu Arg Ser Leu Ser Pro Lys Ser Thr Ser Pro Pro Pro Ser 
                85                  90                  95      


Pro Glu Val Trp Ala Asp Ser Arg Ser Pro Gly Ile Ile Ser Gln Ala 
            100                 105                 110         


Ser Ala Pro Arg Thr Thr Gly Thr Pro Arg Thr Ser Leu Pro His Phe 
        115                 120                 125             


His His Pro Glu Thr Ser Arg Pro Asp Ser Asn Ile Tyr Lys Lys Pro 
    130                 135                 140                 


Pro Ile Tyr Lys Gln Arg Glu Ser Val Gly Gly Ser Pro Gln Thr Lys 
145                 150                 155                 160 


His Leu Ile Glu Asp Leu Ile Ile Glu Ser Ser Lys Phe Pro Ala Ala 
                165                 170                 175     


Gln Pro Pro Asp Pro Asn Gln Pro Ala Lys Ile Glu Thr Asp Tyr Trp 
            180                 185                 190         


Pro Cys Pro Pro Ser Leu Ala Val Val Glu Thr Glu Trp Arg Lys Arg 
        195                 200                 205             


Lys Ala Ser Arg Arg Gly Ala Glu Glu Glu Glu Glu Glu Glu Asp Asp 
    210                 215                 220                 


Asp Ser Gly Glu Glu Met Lys Ala Leu Arg Glu Arg Gln Arg Glu Glu 
225                 230                 235                 240 


Leu Ser Lys Val Thr Ser Asn Leu Gly Lys Met Ile Leu Lys Glu Glu 
                245                 250                 255     


Met Glu Lys Ser Leu Pro Ile Arg Arg Lys Thr Arg Ser Leu Pro Asp 
            260                 265                 270         


Arg Thr Pro Phe His Thr Ser Leu His Gln Gly Thr Ser Lys Ser Ser 
        275                 280                 285             


Ser Leu Pro Ala Tyr Gly Arg Thr Thr Leu Ser Arg Leu Gln Ser Thr 
    290                 295                 300                 


Glu Phe Ser Pro Ser Gly Ser Glu Thr Gly Ser Pro Gly Leu Gln Asn 
305                 310                 315                 320 


Gly Glu Gly Gln Arg Gly Arg Met Asp Arg Gly Asn Ser Leu Pro Cys 
                325                 330                 335     


Val Leu Glu Gln Lys Ile Tyr Pro Tyr Glu Met Leu Val Val Thr Asn 
            340                 345                 350         


Lys Gly Arg Thr Lys Leu Pro Pro Gly Val Asp Arg Met Arg Leu Glu 
        355                 360                 365             


Arg His Leu Ser Ala Glu Asp Phe Ser Arg Val Phe Ala Met Ser Pro 
    370                 375                 380                 


Glu Glu Phe Gly Lys Leu Ala Leu Trp Lys Arg Asn Glu Leu Lys Lys 
385                 390                 395                 400 


Lys Ala Ser Leu Phe 
                405 


<210>  385
<211>  323
<212>  PRT
<213>  Homo sapiens

<400>  385

Met Ala Ala Ala Ala Leu Pro Ala Trp Leu Ser Leu Gln Ser Arg Ala 
1               5                   10                  15      


Arg Thr Leu Arg Ala Phe Ser Thr Ala Val Tyr Ser Ala Thr Pro Val 
            20                  25                  30          


Pro Thr Pro Ser Leu Pro Glu Arg Thr Pro Gly Asn Glu Arg Pro Pro 
        35                  40                  45              


Arg Arg Lys Ala Leu Pro Pro Arg Thr Glu Lys Met Ala Val Asp Gln 
    50                  55                  60                  


Asp Trp Pro Ser Val Tyr Pro Val Ala Ala Pro Phe Lys Pro Ser Ala 
65                  70                  75                  80  


Val Pro Leu Pro Val Arg Met Gly Tyr Pro Val Lys Lys Gly Val Pro 
                85                  90                  95      


Met Ala Lys Glu Gly Asn Leu Glu Leu Leu Lys Ile Pro Asn Phe Leu 
            100                 105                 110         


His Leu Thr Pro Val Ala Ile Lys Lys His Cys Glu Ala Leu Lys Asp 
        115                 120                 125             


Phe Cys Thr Glu Trp Pro Ala Ala Leu Asp Ser Asp Glu Lys Cys Glu 
    130                 135                 140                 


Lys His Phe Pro Ile Glu Ile Asp Ser Thr Asp Tyr Val Ser Ser Gly 
145                 150                 155                 160 


Pro Ser Val Arg Asn Pro Arg Ala Arg Val Val Val Leu Arg Val Lys 
                165                 170                 175     


Leu Ser Ser Leu Asn Leu Asp Asp His Ala Lys Lys Lys Leu Ile Lys 
            180                 185                 190         


Leu Val Gly Glu Arg Tyr Cys Lys Thr Thr Asp Val Leu Thr Ile Lys 
        195                 200                 205             


Thr Asp Arg Cys Pro Leu Arg Arg Gln Asn Tyr Asp Tyr Ala Val Tyr 
    210                 215                 220                 


Leu Leu Thr Val Leu Tyr His Glu Ser Trp Asn Thr Glu Glu Trp Glu 
225                 230                 235                 240 


Lys Ser Lys Thr Glu Ala Asp Met Glu Glu Tyr Ile Trp Glu Asn Ser 
                245                 250                 255     


Ser Ser Glu Arg Asn Ile Leu Glu Thr Leu Leu Gln Met Lys Ala Ala 
            260                 265                 270         


Glu Lys Asn Met Glu Ile Asn Lys Glu Glu Leu Leu Gly Thr Lys Glu 
        275                 280                 285             


Ile Glu Glu Tyr Lys Lys Ser Val Val Ser Leu Lys Asn Glu Glu Glu 
    290                 295                 300                 


Asn Glu Asn Ser Ile Ser Gln Tyr Lys Glu Ser Val Lys Arg Leu Leu 
305                 310                 315                 320 


Asn Val Thr 
            


<210>  386
<211>  146
<212>  PRT
<213>  Homo sapiens

<400>  386

Met Thr Leu Thr Lys Gly Ser Phe Thr Tyr Ser Ser Gly Glu Glu Tyr 
1               5                   10                  15      


Arg Gly Glu Trp Lys Glu Gly Arg Arg His Gly Phe Gly Gln Leu Met 
            20                  25                  30          


Phe Ala Asp Gly Gly Thr Tyr Leu Gly His Phe Glu Asn Gly Leu Phe 
        35                  40                  45              


Asn Gly Phe Gly Val Leu Thr Phe Ser Asp Gly Ser Arg Tyr Glu Gly 
    50                  55                  60                  


Glu Phe Ala Gln Gly Lys Phe Asn Gly Val Gly Val Phe Ile Arg Tyr 
65                  70                  75                  80  


Asp Asn Met Thr Phe Glu Gly Glu Phe Lys Asn Gly Arg Val Asp Gly 
                85                  90                  95      


Phe Gly Leu Leu Thr Phe Pro Asp Gly Ser His Gly Ile Pro Arg Asn 
            100                 105                 110         


Glu Gly Leu Phe Glu Asn Asn Lys Leu Leu Arg Arg Glu Lys Cys Ser 
        115                 120                 125             


Ala Ile Val Gln Arg Ala Gln Ser Ala Ser Lys Ser Ala Arg Asn Leu 
    130                 135                 140                 


Thr Ala 
145     


<210>  387
<211>  323
<212>  PRT
<213>  Homo sapiens

<400>  387

Met Gly Leu Phe Asp Arg Gly Val Gln Met Leu Leu Thr Thr Val Gly 
1               5                   10                  15      


Ala Phe Ala Ala Phe Ser Leu Met Thr Ile Ala Val Gly Thr Asp Tyr 
            20                  25                  30          


Trp Leu Tyr Ser Arg Gly Val Cys Lys Thr Lys Ser Val Ser Glu Asn 
        35                  40                  45              


Glu Thr Ser Lys Lys Asn Glu Glu Val Met Thr His Ser Gly Leu Trp 
    50                  55                  60                  


Arg Thr Cys Cys Leu Glu Gly Asn Phe Lys Gly Leu Cys Lys Gln Ile 
65                  70                  75                  80  


Asp His Phe Pro Glu Asp Ala Asp Tyr Glu Ala Asp Thr Ala Glu Tyr 
                85                  90                  95      


Phe Leu Arg Ala Val Arg Ala Ser Ser Ile Phe Pro Ile Leu Ser Val 
            100                 105                 110         


Ile Leu Leu Phe Met Gly Gly Leu Cys Ile Ala Ala Ser Glu Phe Tyr 
        115                 120                 125             


Lys Thr Arg His Asn Ile Ile Leu Ser Ala Gly Ile Phe Phe Val Ser 
    130                 135                 140                 


Ala Gly Leu Ser Asn Ile Ile Gly Ile Ile Val Tyr Ile Ser Ala Asn 
145                 150                 155                 160 


Ala Gly Asp Pro Ser Lys Ser Asp Ser Lys Lys Asn Ser Tyr Ser Tyr 
                165                 170                 175     


Gly Trp Ser Phe Tyr Phe Gly Ala Leu Ser Phe Ile Ile Ala Glu Met 
            180                 185                 190         


Val Gly Val Leu Ala Val His Met Phe Ile Asp Arg His Lys Gln Leu 
        195                 200                 205             


Arg Ala Thr Ala Arg Ala Thr Asp Tyr Leu Gln Ala Ser Ala Ile Thr 
    210                 215                 220                 


Arg Ile Pro Ser Tyr Arg Tyr Arg Tyr Gln Arg Arg Ser Arg Ser Ser 
225                 230                 235                 240 


Ser Arg Ser Thr Glu Pro Ser His Ser Arg Asp Ala Ser Pro Val Gly 
                245                 250                 255     


Ile Lys Gly Phe Asn Thr Leu Pro Ser Thr Glu Ile Ser Met Tyr Thr 
            260                 265                 270         


Leu Ser Arg Asp Pro Leu Lys Ala Ala Thr Thr Pro Thr Ala Thr Tyr 
        275                 280                 285             


Asn Ser Asp Arg Asp Asn Ser Phe Leu Gln Val His Asn Cys Ile Gln 
    290                 295                 300                 


Lys Glu Asn Lys Asp Ser Leu His Ser Asn Thr Ala Asn Arg Arg Thr 
305                 310                 315                 320 


Thr Pro Val 
            


<210>  388
<211>  177
<212>  PRT
<213>  Homo sapiens

<400>  388

Met Pro Val Lys Arg Ser Leu Lys Leu Asp Gly Leu Leu Glu Glu Asn 
1               5                   10                  15      


Ser Phe Asp Pro Ser Lys Ile Thr Arg Lys Lys Ser Val Ile Thr Tyr 
            20                  25                  30          


Ser Pro Thr Thr Gly Thr Cys Gln Met Ser Leu Phe Ala Ser Pro Thr 
        35                  40                  45              


Ser Ser Glu Glu Gln Lys His Arg Asn Gly Leu Ser Asn Glu Lys Arg 
    50                  55                  60                  


Lys Lys Leu Asn His Pro Ser Leu Thr Glu Ser Lys Glu Ser Thr Thr 
65                  70                  75                  80  


Lys Asp Asn Asp Glu Phe Met Met Leu Leu Ser Lys Val Glu Lys Leu 
                85                  90                  95      


Ser Glu Glu Ile Met Glu Ile Met Gln Asn Leu Ser Ser Ile Gln Ala 
            100                 105                 110         


Leu Glu Gly Ser Arg Glu Leu Glu Asn Leu Ile Gly Ile Ser Cys Ala 
        115                 120                 125             


Ser His Phe Leu Lys Arg Glu Met Gln Lys Thr Lys Glu Leu Met Thr 
    130                 135                 140                 


Lys Val Asn Lys Gln Lys Leu Phe Glu Lys Ser Thr Gly Leu Pro His 
145                 150                 155                 160 


Lys Ala Ser Arg His Leu Asp Ser Tyr Glu Phe Leu Lys Ala Ile Leu 
                165                 170                 175     


Asn 
    


<210>  389
<211>  593
<212>  PRT
<213>  Homo sapiens

<400>  389

Met Gly Ser Gly Ser Ser Ser Tyr Arg Pro Lys Ala Ile Tyr Leu Asp 
1               5                   10                  15      


Ile Asp Gly Arg Ile Gln Lys Val Ile Phe Ser Lys Tyr Cys Asn Ser 
            20                  25                  30          


Ser Asp Ile Met Asp Leu Phe Cys Ile Ala Thr Gly Leu Pro Arg Asn 
        35                  40                  45              


Thr Thr Ile Ser Leu Leu Thr Thr Asp Asp Ala Met Val Ser Ile Asp 
    50                  55                  60                  


Pro Thr Met Pro Ala Asn Ser Glu Arg Thr Pro Tyr Lys Val Arg Pro 
65                  70                  75                  80  


Val Ala Ile Lys Gln Leu Ser Ala Gly Val Glu Asp Lys Arg Thr Thr 
                85                  90                  95      


Ser Arg Gly Gln Ser Ala Glu Arg Pro Leu Arg Asp Arg Arg Val Val 
            100                 105                 110         


Gly Leu Glu Gln Pro Arg Arg Glu Gly Ala Phe Glu Ser Gly Gln Val 
        115                 120                 125             


Glu Pro Arg Pro Arg Glu Pro Gln Gly Cys Tyr Gln Glu Gly Gln Arg 
    130                 135                 140                 


Ile Pro Pro Glu Arg Glu Glu Leu Ile Gln Ser Val Leu Ala Gln Val 
145                 150                 155                 160 


Ala Glu Gln Phe Ser Arg Ala Phe Lys Ile Asn Glu Leu Lys Ala Glu 
                165                 170                 175     


Val Ala Asn His Leu Ala Val Leu Glu Lys Arg Val Glu Leu Glu Gly 
            180                 185                 190         


Leu Lys Val Val Glu Ile Glu Lys Cys Lys Ser Asp Ile Lys Lys Met 
        195                 200                 205             


Arg Glu Glu Leu Ala Ala Arg Ser Ser Arg Thr Asn Cys Pro Cys Lys 
    210                 215                 220                 


Tyr Ser Phe Leu Asp Asn His Lys Lys Leu Thr Pro Arg Arg Asp Val 
225                 230                 235                 240 


Pro Thr Tyr Pro Lys Tyr Leu Leu Ser Pro Glu Thr Ile Glu Ala Leu 
                245                 250                 255     


Arg Lys Pro Thr Phe Asp Val Trp Leu Trp Glu Pro Asn Glu Met Leu 
            260                 265                 270         


Ser Cys Leu Glu His Met Tyr His Asp Leu Gly Leu Val Arg Asp Phe 
        275                 280                 285             


Ser Ile Asn Pro Val Thr Leu Arg Arg Trp Leu Phe Cys Val His Asp 
    290                 295                 300                 


Asn Tyr Arg Asn Asn Pro Phe His Asn Phe Arg His Cys Phe Cys Val 
305                 310                 315                 320 


Ala Gln Met Met Tyr Ser Met Val Trp Leu Cys Ser Leu Gln Glu Lys 
                325                 330                 335     


Phe Ser Gln Thr Asp Ile Leu Ile Leu Met Thr Ala Ala Ile Cys His 
            340                 345                 350         


Asp Leu Asp His Pro Gly Tyr Asn Asn Thr Tyr Gln Ile Asn Ala Arg 
        355                 360                 365             


Thr Glu Leu Ala Val Arg Tyr Asn Asp Ile Ser Pro Leu Glu Asn His 
    370                 375                 380                 


His Cys Ala Val Ala Phe Gln Ile Leu Ala Glu Pro Glu Cys Asn Ile 
385                 390                 395                 400 


Phe Ser Asn Ile Pro Pro Asp Gly Phe Lys Gln Ile Arg Gln Gly Met 
                405                 410                 415     


Ile Thr Leu Ile Leu Ala Thr Asp Met Ala Arg His Ala Glu Ile Met 
            420                 425                 430         


Asp Ser Phe Lys Glu Lys Met Glu Asn Phe Asp Tyr Ser Asn Glu Glu 
        435                 440                 445             


His Met Thr Leu Leu Lys Met Ile Leu Ile Lys Cys Cys Asp Ile Ser 
    450                 455                 460                 


Asn Glu Val Arg Pro Met Glu Val Ala Glu Pro Trp Val Asp Cys Leu 
465                 470                 475                 480 


Leu Glu Glu Tyr Phe Met Gln Ser Asp Arg Glu Lys Ser Glu Gly Leu 
                485                 490                 495     


Pro Val Ala Pro Phe Met Asp Arg Asp Lys Val Thr Lys Ala Thr Ala 
            500                 505                 510         


Gln Ile Gly Phe Ile Lys Phe Val Leu Ile Pro Met Phe Glu Thr Val 
        515                 520                 525             


Thr Lys Leu Phe Pro Met Val Glu Glu Ile Met Leu Gln Pro Leu Trp 
    530                 535                 540                 


Glu Ser Arg Asp Arg Tyr Glu Glu Leu Lys Arg Ile Asp Asp Ala Met 
545                 550                 555                 560 


Lys Glu Leu Gln Lys Lys Thr Asp Ser Leu Thr Ser Gly Ala Thr Glu 
                565                 570                 575     


Lys Ser Arg Glu Arg Ser Arg Asp Val Lys Asn Ser Glu Gly Asp Cys 
            580                 585                 590         


Ala 
    


<210>  390
<211>  231
<212>  PRT
<213>  Homo sapiens

<400>  390

Met Phe Leu Val Gly Leu Thr Gly Gly Ile Ala Ser Gly Lys Ser Ser 
1               5                   10                  15      


Val Ile Gln Val Phe Gln Gln Leu Gly Cys Ala Val Ile Asp Val Asp 
            20                  25                  30          


Val Met Ala Arg His Val Val Gln Pro Gly Tyr Pro Ala His Arg Arg 
        35                  40                  45              


Ile Val Glu Val Phe Gly Thr Glu Val Leu Leu Glu Asn Gly Asp Ile 
    50                  55                  60                  


Asn Arg Lys Val Leu Gly Asp Leu Ile Phe Asn Gln Pro Asp Arg Arg 
65                  70                  75                  80  


Gln Leu Leu Asn Ala Ile Thr His Pro Glu Ile Arg Lys Glu Met Met 
                85                  90                  95      


Lys Glu Thr Phe Lys Tyr Phe Leu Arg Gly Tyr Arg Tyr Val Ile Leu 
            100                 105                 110         


Asp Ile Pro Leu Leu Phe Glu Thr Lys Lys Leu Leu Lys Tyr Met Lys 
        115                 120                 125             


His Thr Val Val Val Tyr Cys Asp Arg Asp Thr Gln Leu Ala Arg Leu 
    130                 135                 140                 


Met Arg Arg Asn Ser Leu Asn Arg Lys Asp Ala Glu Ala Arg Ile Asn 
145                 150                 155                 160 


Ala Gln Leu Pro Leu Thr Asp Lys Ala Arg Met Ala Arg His Val Leu 
                165                 170                 175     


Asp Asn Ser Gly Glu Trp Ser Val Thr Lys Arg Gln Val Ile Leu Leu 
            180                 185                 190         


His Thr Glu Leu Glu Arg Ser Leu Glu Tyr Leu Pro Leu Arg Phe Gly 
        195                 200                 205             


Val Leu Thr Gly Leu Ala Ala Ile Ala Ser Leu Leu Tyr Leu Leu Thr 
    210                 215                 220                 


His Tyr Leu Leu Pro Tyr Ala 
225                 230     


<210>  391
<211>  253
<212>  PRT
<213>  Homo sapiens

<400>  391

Met Glu Leu Glu Gln Arg Glu Gly Thr Met Ala Ala Val Gly Phe Glu 
1               5                   10                  15      


Glu Phe Ser Ala Pro Pro Gly Ser Glu Leu Ala Leu Pro Pro Leu Phe 
            20                  25                  30          


Gly Gly His Ile Leu Glu Ser Glu Leu Glu Thr Glu Val Glu Phe Val 
        35                  40                  45              


Ser Gly Gly Leu Gly Gly Ser Gly Leu Arg Glu Arg Asp Glu Glu Glu 
    50                  55                  60                  


Glu Ala Ala Arg Gly Arg Arg Arg Arg Gln Arg Glu Leu Asn Arg Arg 
65                  70                  75                  80  


Lys Tyr Gln Ala Leu Gly Arg Arg Cys Arg Glu Ile Glu Gln Val Asn 
                85                  90                  95      


Glu Arg Val Leu Asn Arg Leu His Gln Val Gln Arg Ile Thr Arg Arg 
            100                 105                 110         


Leu Gln Gln Glu Arg Arg Phe Leu Met Arg Val Leu Asp Ser Tyr Gly 
        115                 120                 125             


Asp Asp Tyr Arg Ala Ser Gln Phe Thr Ile Val Leu Glu Asp Glu Gly 
    130                 135                 140                 


Ser Gln Gly Thr Asp Ala Pro Thr Pro Gly Asn Ala Glu Asn Glu Pro 
145                 150                 155                 160 


Pro Glu Lys Glu Thr Leu Ser Pro Pro Arg Arg Thr Pro Ala Pro Pro 
                165                 170                 175     


Glu Pro Gly Ser Pro Ala Pro Gly Glu Gly Pro Ser Gly Arg Lys Arg 
            180                 185                 190         


Arg Arg Val Pro Arg Asp Gly Arg Arg Ala Gly Asn Ala Leu Thr Pro 
        195                 200                 205             


Glu Leu Ala Pro Val Gln Ile Lys Val Glu Glu Asp Phe Gly Phe Glu 
    210                 215                 220                 


Ala Asp Glu Ala Leu Asp Ser Ser Trp Val Ser Arg Gly Pro Asp Lys 
225                 230                 235                 240 


Leu Leu Pro Tyr Pro Thr Leu Ala Ser Pro Ala Ser Asp 
                245                 250             


<210>  392
<211>  616
<212>  PRT
<213>  Homo sapiens

<400>  392

Met Val Gly Gln Leu Ser Glu Gly Ala Ile Ala Ala Ile Met Gln Lys 
1               5                   10                  15      


Gly Asp Thr Asn Ile Lys Pro Ile Leu Gln Val Ile Asn Ile Arg Pro 
            20                  25                  30          


Ile Thr Thr Gly Asn Ser Pro Pro Arg Tyr Arg Leu Leu Met Ser Asp 
        35                  40                  45              


Gly Leu Asn Thr Leu Ser Ser Phe Met Leu Ala Thr Gln Leu Asn Pro 
    50                  55                  60                  


Leu Val Glu Glu Glu Gln Leu Ser Ser Asn Cys Val Cys Gln Ile His 
65                  70                  75                  80  


Arg Phe Ile Val Asn Thr Leu Lys Asp Gly Arg Arg Val Val Ile Leu 
                85                  90                  95      


Met Glu Leu Glu Val Leu Lys Ser Ala Glu Ala Val Gly Val Lys Ile 
            100                 105                 110         


Gly Asn Pro Val Pro Tyr Asn Glu Gly Leu Gly Gln Pro Gln Val Ala 
        115                 120                 125             


Pro Pro Ala Pro Ala Ala Ser Pro Ala Ala Ser Ser Arg Pro Gln Pro 
    130                 135                 140                 


Gln Asn Gly Ser Ser Gly Met Gly Ser Thr Val Ser Lys Ala Tyr Gly 
145                 150                 155                 160 


Ala Ser Lys Thr Phe Gly Lys Ala Ala Gly Pro Ser Leu Ser His Thr 
                165                 170                 175     


Ser Gly Gly Thr Gln Ser Lys Val Val Pro Ile Ala Ser Leu Thr Pro 
            180                 185                 190         


Tyr Gln Ser Lys Trp Thr Ile Cys Ala Arg Val Thr Asn Lys Ser Gln 
        195                 200                 205             


Ile Arg Thr Trp Ser Asn Ser Arg Gly Glu Gly Lys Leu Phe Ser Leu 
    210                 215                 220                 


Glu Leu Val Asp Glu Ser Gly Glu Ile Arg Ala Thr Ala Phe Asn Glu 
225                 230                 235                 240 


Gln Val Asp Lys Phe Phe Pro Leu Ile Glu Val Asn Lys Val Tyr Tyr 
                245                 250                 255     


Phe Ser Lys Gly Thr Leu Lys Ile Ala Asn Lys Gln Phe Thr Ala Val 
            260                 265                 270         


Lys Asn Asp Tyr Glu Met Thr Phe Asn Asn Glu Thr Ser Val Met Pro 
        275                 280                 285             


Cys Glu Asp Asp His His Leu Pro Thr Val Gln Phe Asp Phe Thr Gly 
    290                 295                 300                 


Ile Asp Asp Leu Glu Asn Lys Ser Lys Asp Ser Leu Val Asp Ile Ile 
305                 310                 315                 320 


Gly Ile Cys Lys Ser Tyr Glu Asp Ala Thr Lys Ile Thr Val Arg Ser 
                325                 330                 335     


Asn Asn Arg Glu Val Ala Lys Arg Asn Ile Tyr Leu Met Asp Thr Ser 
            340                 345                 350         


Gly Lys Val Val Thr Ala Thr Leu Trp Gly Glu Asp Ala Asp Lys Phe 
        355                 360                 365             


Asp Gly Ser Arg Gln Pro Val Leu Ala Ile Lys Gly Ala Arg Val Ser 
    370                 375                 380                 


Asp Phe Gly Gly Arg Ser Leu Ser Val Leu Ser Ser Ser Thr Ile Ile 
385                 390                 395                 400 


Ala Asn Pro Asp Ile Pro Glu Ala Tyr Lys Leu Arg Gly Trp Phe Asp 
                405                 410                 415     


Ala Glu Gly Gln Ala Leu Asp Gly Val Ser Ile Ser Asp Leu Lys Ser 
            420                 425                 430         


Gly Gly Val Gly Gly Ser Asn Thr Asn Trp Lys Thr Leu Tyr Glu Val 
        435                 440                 445             


Lys Ser Glu Asn Leu Gly Gln Gly Asp Lys Pro Asp Tyr Phe Ser Ser 
    450                 455                 460                 


Val Ala Thr Val Val Tyr Leu Arg Lys Glu Asn Cys Met Tyr Gln Ala 
465                 470                 475                 480 


Cys Pro Thr Gln Asp Cys Asn Lys Lys Val Ile Asp Gln Gln Asn Gly 
                485                 490                 495     


Leu Tyr Arg Cys Glu Lys Cys Asp Thr Glu Phe Pro Asn Phe Lys Tyr 
            500                 505                 510         


Arg Met Ile Leu Ser Val Asn Ile Ala Asp Phe Gln Glu Asn Gln Trp 
        515                 520                 525             


Val Thr Cys Phe Gln Glu Ser Ala Glu Ala Ile Leu Gly Gln Asn Ala 
    530                 535                 540                 


Ala Tyr Leu Gly Glu Leu Lys Asp Lys Asn Glu Gln Ala Phe Glu Glu 
545                 550                 555                 560 


Val Phe Gln Asn Ala Asn Phe Arg Ser Phe Ile Phe Arg Val Arg Val 
                565                 570                 575     


Lys Val Glu Thr Tyr Asn Asp Glu Ser Arg Ile Lys Ala Thr Val Met 
            580                 585                 590         


Asp Val Lys Pro Val Asp Tyr Arg Glu Tyr Gly Arg Arg Leu Val Met 
        595                 600                 605             


Ser Ile Arg Arg Ser Ala Leu Met 
    610                 615     


<210>  393
<211>  125
<212>  PRT
<213>  Homo sapiens

<400>  393

Met Pro His Ser Ser Asp Ser Ser Asp Ser Ser Phe Ser Arg Ser Pro 
1               5                   10                  15      


Pro Pro Gly Lys Gln Asp Ser Ser Asp Asp Val Arg Arg Val Gln Arg 
            20                  25                  30          


Arg Glu Lys Asn Arg Ile Ala Ala Gln Lys Ser Arg Gln Arg Gln Thr 
        35                  40                  45              


Gln Lys Ala Asp Thr Leu His Leu Glu Ser Glu Asp Leu Glu Lys Gln 
    50                  55                  60                  


Asn Ala Ala Leu Arg Lys Glu Ile Lys Gln Leu Thr Glu Glu Leu Lys 
65                  70                  75                  80  


Tyr Phe Thr Ser Val Leu Asn Ser His Glu Pro Leu Cys Ser Val Leu 
                85                  90                  95      


Ala Ala Ser Thr Pro Ser Pro Pro Glu Val Val Tyr Ser Ala His Ala 
            100                 105                 110         


Phe His Gln Pro His Val Ser Ser Pro Arg Phe Gln Pro 
        115                 120                 125 


<210>  394
<211>  462
<212>  PRT
<213>  Homo sapiens

<400>  394

Met Ala Gly Gly Lys Gln Phe Thr Phe Ser Tyr Glu Asn Glu Val Cys 
1               5                   10                  15      


Lys Gln Asp Tyr Phe Ile Lys Ser Pro Pro Ser Gln Leu Phe Ser Ser 
            20                  25                  30          


Val Thr Ser Trp Lys Lys Arg Phe Phe Ile Leu Ser Lys Ala Gly Glu 
        35                  40                  45              


Lys Ser Phe Ser Leu Ser Tyr Tyr Lys Asp His His His Arg Gly Ser 
    50                  55                  60                  


Ile Glu Ile Asp Gln Asn Ser Ser Val Glu Val Gly Ile Ser Ser Gln 
65                  70                  75                  80  


Glu Lys Met Gln Ser Val Gln Lys Met Phe Lys Cys His Pro Asp Glu 
                85                  90                  95      


Val Met Ser Ile Arg Thr Thr Asn Arg Glu Tyr Phe Leu Ile Gly His 
            100                 105                 110         


Asp Arg Glu Lys Ile Lys Asp Trp Val Ser Phe Met Ser Ser Phe Arg 
        115                 120                 125             


Gln Asp Ile Lys Ala Thr Gln Gln Asn Thr Glu Glu Glu Leu Ser Leu 
    130                 135                 140                 


Gly Asn Lys Arg Thr Leu Phe Tyr Ser Ser Pro Leu Leu Gly Pro Ser 
145                 150                 155                 160 


Ser Thr Ser Glu Ala Val Gly Ser Ser Ser Pro Arg Asn Gly Leu Gln 
                165                 170                 175     


Asp Lys His Leu Met Glu Gln Ser Ser Pro Gly Phe Arg Gln Thr His 
            180                 185                 190         


Leu Gln Asp Leu Ser Glu Ala Thr Gln Asp Val Lys Glu Glu Asn His 
        195                 200                 205             


Tyr Leu Thr Pro Arg Ser Val Leu Leu Glu Leu Asp Asn Ile Ile Ala 
    210                 215                 220                 


Ser Ser Asp Ser Gly Glu Ser Ile Glu Thr Asp Gly Pro Asp Gln Val 
225                 230                 235                 240 


Ser Gly Arg Ile Glu Cys His Tyr Glu Pro Met Glu Ser Tyr Phe Phe 
                245                 250                 255     


Lys Glu Thr Ser His Glu Ser Val Asp Ser Ser Lys Glu Glu Pro Gln 
            260                 265                 270         


Thr Leu Pro Glu Thr Gln Asp Gly Asp Leu His Leu Gln Glu Gln Gly 
        275                 280                 285             


Ser Gly Ile Asp Trp Cys Leu Ser Pro Ala Asp Val Glu Ala Gln Thr 
    290                 295                 300                 


Thr Asn Asp Gln Lys Gly Ser Ala Ser Leu Thr Val Val Gln Leu Ser 
305                 310                 315                 320 


Ile Leu Ile Asn Asn Ile Pro Asp Glu Ser Gln Val Glu Lys Leu Asn 
                325                 330                 335     


Val Phe Leu Ser Pro Pro Asp Val Ile Asn Tyr Leu Ala Leu Thr Glu 
            340                 345                 350         


Ala Thr Gly Arg Ile Cys Val Ser Gln Trp Glu Gly Pro Pro Arg Leu 
        355                 360                 365             


Gly Cys Ile Phe Cys His Gly Asp His Leu Leu Ala Val Asn Asp Leu 
    370                 375                 380                 


Lys Pro Gln Ser Leu Glu Glu Val Ser Leu Phe Leu Thr Arg Ser Ile 
385                 390                 395                 400 


Gln Lys Glu Lys Leu Lys Leu Thr Ile Gly Arg Ile Pro Asn Ser Glu 
                405                 410                 415     


Thr Phe His Ala Ala Ser Cys Met Cys Pro Ser Lys Cys Gln Ser Ala 
            420                 425                 430         


Ala Pro Ser Gln Leu Asp Lys Pro Arg Leu Asn Arg Ala Pro Lys Arg 
        435                 440                 445             


Ser Pro Ala Ile Lys Lys Ser Gln Gln Lys Gly Ala Arg Glu 
    450                 455                 460         


<210>  395
<211>  251
<212>  PRT
<213>  Homo sapiens

<400>  395

Met Glu Ser Gly Lys Met Ala Pro Pro Lys Asn Ala Pro Arg Asp Ala 
1               5                   10                  15      


Leu Val Met Ala Gln Ile Leu Lys Asp Met Gly Ile Thr Glu Tyr Glu 
            20                  25                  30          


Pro Arg Val Ile Asn Gln Met Leu Glu Phe Ala Phe Arg Tyr Val Thr 
        35                  40                  45              


Thr Ile Leu Asp Asp Ala Lys Ile Tyr Ser Ser His Ala Lys Lys Pro 
    50                  55                  60                  


Asn Val Asp Ala Asp Asp Val Arg Leu Ala Ile Gln Cys Arg Ala Asp 
65                  70                  75                  80  


Gln Ser Phe Thr Ser Pro Pro Pro Arg Asp Phe Leu Leu Asp Ile Ala 
                85                  90                  95      


Arg Gln Lys Asn Gln Thr Pro Leu Pro Leu Ile Lys Pro Tyr Ala Gly 
            100                 105                 110         


Pro Arg Leu Pro Pro Asp Arg Tyr Cys Leu Thr Ala Pro Asn Tyr Arg 
        115                 120                 125             


Leu Lys Ser Leu Ile Lys Lys Gly Pro Asn Gln Gly Arg Leu Val Pro 
    130                 135                 140                 


Arg Leu Ser Val Gly Ala Val Ser Ser Lys Pro Thr Thr Pro Thr Ile 
145                 150                 155                 160 


Ala Thr Pro Gln Thr Val Ser Val Pro Asn Lys Val Ala Thr Pro Met 
                165                 170                 175     


Ser Val Thr Ser Gln Arg Phe Thr Val Gln Ile Pro Pro Ser Gln Ser 
            180                 185                 190         


Thr Pro Val Lys Pro Val Pro Ala Thr Thr Ala Val Gln Asn Val Leu 
        195                 200                 205             


Ile Asn Pro Ser Met Ile Gly Pro Lys Asn Ile Leu Ile Thr Thr Asn 
    210                 215                 220                 


Met Val Ser Ser Gln Asn Thr Ala Asn Glu Ala Asn Pro Leu Lys Arg 
225                 230                 235                 240 


Lys His Glu Asp Asp Asp Asp Asn Asp Ile Met 
                245                 250     


<210>  396
<211>  186
<212>  PRT
<213>  Homo sapiens

<400>  396

Met Leu Ala Leu Ile Ser Arg Leu Leu Asp Trp Phe Arg Ser Leu Phe 
1               5                   10                  15      


Trp Lys Glu Glu Met Glu Leu Thr Leu Val Gly Leu Gln Tyr Ser Gly 
            20                  25                  30          


Lys Thr Thr Phe Val Asn Val Ile Ala Ser Gly Gln Phe Ser Glu Asp 
        35                  40                  45              


Met Ile Pro Thr Val Gly Phe Asn Met Arg Lys Val Thr Lys Gly Asn 
    50                  55                  60                  


Val Thr Ile Lys Ile Trp Asp Ile Gly Gly Gln Pro Arg Phe Arg Ser 
65                  70                  75                  80  


Met Trp Glu Arg Tyr Cys Arg Gly Val Asn Ala Ile Val Tyr Met Ile 
                85                  90                  95      


Asp Ala Ala Asp Arg Glu Lys Ile Glu Ala Ser Arg Asn Glu Leu His 
            100                 105                 110         


Asn Leu Leu Asp Lys Pro Gln Leu Gln Gly Ile Pro Val Leu Val Leu 
        115                 120                 125             


Gly Asn Lys Arg Asp Leu Pro Asn Ala Leu Asp Glu Lys Gln Leu Ile 
    130                 135                 140                 


Glu Lys Met Asn Leu Ser Ala Ile Gln Asp Arg Glu Ile Cys Cys Tyr 
145                 150                 155                 160 


Ser Ile Ser Cys Lys Glu Lys Asp Asn Ile Asp Ile Thr Leu Gln Trp 
                165                 170                 175     


Leu Ile Gln His Ser Lys Ser Arg Arg Ser 
            180                 185     


<210>  397
<211>  297
<212>  PRT
<213>  Homo sapiens

<400>  397

Met Glu Asp Tyr Thr Lys Ile Glu Lys Ile Gly Glu Gly Thr Tyr Gly 
1               5                   10                  15      


Val Val Tyr Lys Gly Arg His Lys Thr Thr Gly Gln Val Val Ala Met 
            20                  25                  30          


Lys Lys Ile Arg Leu Glu Ser Glu Glu Glu Gly Val Pro Ser Thr Ala 
        35                  40                  45              


Ile Arg Glu Ile Ser Leu Leu Lys Glu Leu Arg His Pro Asn Ile Val 
    50                  55                  60                  


Ser Leu Gln Asp Val Leu Met Gln Asp Ser Arg Leu Tyr Leu Ile Phe 
65                  70                  75                  80  


Glu Phe Leu Ser Met Asp Leu Lys Lys Tyr Leu Asp Ser Ile Pro Pro 
                85                  90                  95      


Gly Gln Tyr Met Asp Ser Ser Leu Val Lys Ser Tyr Leu Tyr Gln Ile 
            100                 105                 110         


Leu Gln Gly Ile Val Phe Cys His Ser Arg Arg Val Leu His Arg Asp 
        115                 120                 125             


Leu Lys Pro Gln Asn Leu Leu Ile Asp Asp Lys Gly Thr Ile Lys Leu 
    130                 135                 140                 


Ala Asp Phe Gly Leu Ala Arg Ala Phe Gly Ile Pro Ile Arg Val Tyr 
145                 150                 155                 160 


Thr His Glu Val Val Thr Leu Trp Tyr Arg Ser Pro Glu Val Leu Leu 
                165                 170                 175     


Gly Ser Ala Arg Tyr Ser Thr Pro Val Asp Ile Trp Ser Ile Gly Thr 
            180                 185                 190         


Ile Phe Ala Glu Leu Ala Thr Lys Lys Pro Leu Phe His Gly Asp Ser 
        195                 200                 205             


Glu Ile Asp Gln Leu Phe Arg Ile Phe Arg Ala Leu Gly Thr Pro Asn 
    210                 215                 220                 


Asn Glu Val Trp Pro Glu Val Glu Ser Leu Gln Asp Tyr Lys Asn Thr 
225                 230                 235                 240 


Phe Pro Lys Trp Lys Pro Gly Ser Leu Ala Ser His Val Lys Asn Leu 
                245                 250                 255     


Asp Glu Asn Gly Leu Asp Leu Leu Ser Lys Met Leu Ile Tyr Asp Pro 
            260                 265                 270         


Ala Lys Arg Ile Ser Gly Lys Met Ala Leu Asn His Pro Tyr Phe Asn 
        275                 280                 285             


Asp Leu Asp Asn Gln Ile Lys Lys Met 
    290                 295         


<210>  398
<211>  693
<212>  PRT
<213>  Homo sapiens

<400>  398

Met Ala Gln Gly Ser His Gln Ile Asp Phe Gln Val Leu His Asp Leu 
1               5                   10                  15      


Arg Gln Lys Phe Pro Glu Val Pro Glu Val Val Val Ser Arg Cys Met 
            20                  25                  30          


Leu Gln Asn Asn Asn Asn Leu Asp Ala Cys Cys Ala Val Leu Ser Gln 
        35                  40                  45              


Glu Ser Thr Arg Tyr Leu Tyr Gly Glu Gly Asp Leu Asn Phe Ser Asp 
    50                  55                  60                  


Asp Ser Gly Ile Ser Gly Leu Arg Asn His Met Thr Ser Leu Asn Leu 
65                  70                  75                  80  


Asp Leu Gln Ser Gln Asn Ile Tyr His His Gly Arg Glu Gly Ser Arg 
                85                  90                  95      


Met Asn Gly Ser Arg Thr Leu Thr His Ser Ile Ser Asp Gly Gln Leu 
            100                 105                 110         


Gln Gly Gly Gln Ser Asn Ser Glu Leu Phe Gln Gln Glu Pro Gln Thr 
        115                 120                 125             


Ala Pro Ala Gln Val Pro Gln Gly Phe Asn Val Phe Gly Met Ser Ser 
    130                 135                 140                 


Ser Ser Gly Ala Ser Asn Ser Ala Pro His Leu Gly Phe His Leu Gly 
145                 150                 155                 160 


Ser Lys Gly Thr Ser Ser Leu Ser Gln Gln Thr Pro Arg Phe Asn Pro 
                165                 170                 175     


Ile Met Val Thr Leu Ala Pro Asn Ile Gln Thr Gly Arg Asn Thr Pro 
            180                 185                 190         


Thr Ser Leu His Ile His Gly Val Pro Pro Pro Val Leu Asn Ser Pro 
        195                 200                 205             


Gln Gly Asn Ser Ile Tyr Ile Arg Pro Tyr Ile Thr Thr Pro Gly Gly 
    210                 215                 220                 


Thr Thr Arg Gln Thr Gln Gln His Ser Gly Trp Val Ser Gln Phe Asn 
225                 230                 235                 240 


Pro Met Asn Pro Gln Gln Val Tyr Gln Pro Ser Gln Pro Gly Pro Trp 
                245                 250                 255     


Thr Thr Cys Pro Ala Ser Asn Pro Leu Ser His Thr Ser Ser Gln Gln 
            260                 265                 270         


Pro Asn Gln Gln Gly His Gln Thr Ser His Val Tyr Met Pro Ile Ser 
        275                 280                 285             


Ser Pro Thr Thr Ser Gln Pro Pro Thr Ile His Ser Ser Gly Ser Ser 
    290                 295                 300                 


Gln Ser Ser Ala His Ser Gln Tyr Asn Ile Gln Asn Ile Ser Thr Gly 
305                 310                 315                 320 


Pro Arg Lys Asn Gln Ile Glu Ile Lys Leu Glu Pro Pro Gln Arg Asn 
                325                 330                 335     


Asn Ser Ser Lys Leu Arg Ser Ser Gly Pro Arg Thr Ser Ser Thr Ser 
            340                 345                 350         


Ser Ser Val Asn Ser Gln Thr Leu Asn Arg Asn Gln Pro Thr Val Tyr 
        355                 360                 365             


Ile Ala Ala Ser Pro Pro Asn Thr Asp Glu Leu Met Ser Arg Ser Gln 
    370                 375                 380                 


Pro Lys Val Tyr Ile Ser Ala Asn Ala Ala Thr Gly Asp Glu Gln Val 
385                 390                 395                 400 


Met Arg Asn Gln Pro Thr Leu Phe Ile Ser Thr Asn Ser Gly Ala Ser 
                405                 410                 415     


Ala Ala Ser Arg Asn Met Ser Gly Gln Val Ser Met Gly Pro Ala Phe 
            420                 425                 430         


Ile His His His Pro Pro Lys Ser Arg Ala Ile Gly Asn Asn Ser Ala 
        435                 440                 445             


Thr Ser Pro Arg Val Val Val Thr Gln Pro Asn Thr Lys Tyr Thr Phe 
    450                 455                 460                 


Lys Ile Thr Val Ser Pro Asn Lys Pro Pro Ala Val Ser Pro Gly Val 
465                 470                 475                 480 


Val Ser Pro Thr Phe Glu Leu Thr Asn Leu Leu Asn His Pro Asp His 
                485                 490                 495     


Tyr Val Glu Thr Glu Asn Ile Gln His Leu Thr Asp Pro Thr Leu Ala 
            500                 505                 510         


His Val Asp Arg Ile Ser Glu Thr Arg Lys Leu Ser Met Gly Ser Asp 
        515                 520                 525             


Asp Ala Ala Tyr Thr Gln Ala Leu Leu Val His Gln Lys Ala Arg Met 
    530                 535                 540                 


Glu Arg Leu Gln Arg Glu Leu Glu Ile Gln Lys Lys Lys Leu Asp Lys 
545                 550                 555                 560 


Leu Lys Ser Glu Val Asn Glu Met Glu Asn Asn Leu Thr Arg Arg Arg 
                565                 570                 575     


Leu Lys Arg Ser Asn Ser Ile Ser Gln Ile Pro Ser Leu Glu Glu Met 
            580                 585                 590         


Gln Gln Leu Arg Ser Cys Asn Arg Gln Leu Gln Ile Asp Ile Asp Cys 
        595                 600                 605             


Leu Thr Lys Glu Ile Asp Leu Phe Gln Ala Arg Gly Pro His Phe Asn 
    610                 615                 620                 


Pro Ser Ala Ile His Asn Phe Tyr Asp Asn Ile Gly Phe Val Gly Pro 
625                 630                 635                 640 


Val Pro Pro Lys Pro Lys Asp Gln Arg Ser Ile Ile Lys Thr Pro Lys 
                645                 650                 655     


Thr Gln Asp Thr Glu Asp Asp Glu Gly Ala Gln Trp Asn Cys Thr Ala 
            660                 665                 670         


Cys Thr Phe Leu Asn His Pro Ala Leu Ile Arg Cys Glu Gln Cys Glu 
        675                 680                 685             


Met Pro Arg His Phe 
    690             


<210>  399
<211>  697
<212>  PRT
<213>  Homo sapiens

<400>  399

Met Gly Glu Arg Ala Gly Ser Pro Gly Thr Asp Gln Glu Arg Lys Ala 
1               5                   10                  15      


Gly Lys His His Tyr Ser Tyr Leu Ser Asp Phe Glu Thr Pro Gln Ser 
            20                  25                  30          


Ser Gly Arg Ser Ser Leu Val Ser Ser Ser Pro Ala Ser Val Arg Arg 
        35                  40                  45              


Lys Asn Pro Lys Arg Gln Thr Ser Asp Gly Gln Val His His Gln Ala 
    50                  55                  60                  


Pro Arg Lys Pro Ser Pro Lys Gly Leu Pro Asn Arg Lys Gly Val Arg 
65                  70                  75                  80  


Val Gly Phe Arg Ser Gln Ser Leu Asn Arg Glu Pro Leu Arg Lys Asp 
                85                  90                  95      


Thr Asp Leu Val Thr Lys Arg Ile Leu Ser Ala Arg Leu Leu Lys Ile 
            100                 105                 110         


Asn Glu Leu Gln Asn Glu Val Ser Glu Leu Gln Val Lys Leu Ala Glu 
        115                 120                 125             


Leu Leu Lys Glu Asn Lys Ser Leu Lys Arg Leu Gln Tyr Arg Gln Glu 
    130                 135                 140                 


Lys Ala Leu Asn Lys Phe Glu Asp Ala Glu Asn Glu Ile Ser Gln Leu 
145                 150                 155                 160 


Ile Phe Arg His Asn Asn Glu Ile Thr Ala Leu Lys Glu Arg Leu Arg 
                165                 170                 175     


Lys Ser Gln Glu Lys Glu Arg Ala Thr Glu Lys Arg Val Lys Asp Thr 
            180                 185                 190         


Glu Ser Glu Leu Phe Arg Thr Lys Phe Ser Leu Gln Lys Leu Lys Glu 
        195                 200                 205             


Ile Ser Glu Ala Arg His Leu Pro Glu Arg Asp Asp Leu Ala Lys Lys 
    210                 215                 220                 


Leu Val Ser Ala Glu Leu Lys Leu Asp Asp Thr Glu Arg Arg Ile Lys 
225                 230                 235                 240 


Glu Leu Ser Lys Asn Leu Glu Leu Ser Thr Asn Ser Phe Gln Arg Gln 
                245                 250                 255     


Leu Leu Ala Glu Arg Lys Arg Ala Tyr Glu Ala His Asp Glu Asn Lys 
            260                 265                 270         


Val Leu Gln Lys Glu Val Gln Arg Leu Tyr His Lys Leu Lys Glu Lys 
        275                 280                 285             


Glu Arg Glu Leu Asp Ile Lys Asn Ile Tyr Ser Asn Arg Leu Pro Lys 
    290                 295                 300                 


Ser Ser Pro Asn Lys Glu Lys Glu Leu Ala Leu Arg Lys Asn Ala Ala 
305                 310                 315                 320 


Cys Gln Ser Asp Phe Ala Asp Leu Cys Thr Lys Gly Val Gln Thr Met 
                325                 330                 335     


Glu Asp Phe Lys Pro Glu Glu Tyr Pro Leu Thr Pro Glu Thr Ile Met 
            340                 345                 350         


Cys Tyr Glu Asn Lys Trp Glu Glu Pro Gly His Leu Thr Leu Asp Leu 
        355                 360                 365             


Gln Ser Gln Lys Gln Asp Arg His Gly Glu Ala Gly Ile Leu Asn Pro 
    370                 375                 380                 


Ile Met Glu Arg Glu Glu Lys Phe Val Thr Asp Glu Glu Leu His Val 
385                 390                 395                 400 


Val Lys Gln Glu Val Glu Lys Leu Glu Asp Glu Trp Glu Arg Glu Glu 
                405                 410                 415     


Leu Asp Lys Lys Gln Lys Glu Lys Ala Ser Leu Leu Glu Arg Glu Glu 
            420                 425                 430         


Lys Pro Glu Trp Glu Thr Gly Arg Tyr Gln Leu Gly Met Tyr Pro Ile 
        435                 440                 445             


Gln Asn Met Asp Lys Leu Gln Gly Glu Glu Glu Glu Arg Leu Lys Arg 
    450                 455                 460                 


Glu Met Leu Leu Ala Lys Leu Asn Glu Ile Asp Arg Glu Leu Gln Asp 
465                 470                 475                 480 


Ser Arg Asn Leu Lys Tyr Pro Val Leu Pro Leu Leu Pro Asp Phe Glu 
                485                 490                 495     


Ser Lys Leu His Ser Pro Glu Arg Ser Pro Lys Thr Tyr Arg Phe Ser 
            500                 505                 510         


Glu Ser Ser Glu Arg Leu Phe Asn Gly His His Leu Gln Asp Ile Ser 
        515                 520                 525             


Phe Ser Thr Pro Lys Gly Glu Gly Gln Asn Ser Gly Asn Val Arg Ser 
    530                 535                 540                 


Pro Ala Ser Pro Asn Glu Phe Ala Phe Gly Ser Tyr Val Pro Ser Phe 
545                 550                 555                 560 


Ala Lys Thr Ser Glu Arg Ser Asn Pro Phe Ser Gln Lys Ser Ser Phe 
                565                 570                 575     


Leu Asp Phe Gln Arg Asn Ser Met Glu Lys Leu Ser Lys Asp Gly Val 
            580                 585                 590         


Asp Leu Ile Thr Arg Lys Glu Lys Lys Ala Asn Leu Met Glu Gln Leu 
        595                 600                 605             


Phe Gly Ala Ser Gly Ser Ser Thr Ile Ser Ser Lys Ser Ser Asp Pro 
    610                 615                 620                 


Asn Ser Val Ala Ser Ser Lys Gly Asp Ile Asp Pro Leu Asn Phe Leu 
625                 630                 635                 640 


Pro Gly Asn Lys Gly Ser Arg Asp Gln Glu His Asp Glu Asp Glu Gly 
                645                 650                 655     


Phe Phe Leu Ser Glu Gly Arg Ser Phe Asn Pro Asn Arg His Arg Leu 
            660                 665                 670         


Lys His Ala Asp Asp Lys Pro Ala Val Lys Ala Ala Asp Ser Val Glu 
        675                 680                 685             


Asp Glu Ile Glu Glu Val Ala Leu Arg 
    690                 695         


<210>  400
<211>  173
<212>  PRT
<213>  Homo sapiens

<400>  400

Met Asp Val Thr Ile Gln His Pro Trp Phe Lys Arg Thr Leu Gly Pro 
1               5                   10                  15      


Phe Tyr Pro Ser Arg Leu Phe Asp Gln Phe Phe Gly Glu Gly Leu Phe 
            20                  25                  30          


Glu Tyr Asp Leu Leu Pro Phe Leu Ser Ser Thr Ile Ser Pro Tyr Tyr 
        35                  40                  45              


Arg Gln Ser Leu Phe Arg Thr Val Leu Asp Ser Gly Ile Ser Glu Val 
    50                  55                  60                  


Arg Ser Asp Arg Asp Lys Phe Val Ile Phe Leu Asp Val Lys His Phe 
65                  70                  75                  80  


Ser Pro Glu Asp Leu Thr Val Lys Val Gln Asp Asp Phe Val Glu Ile 
                85                  90                  95      


His Gly Lys His Asn Glu Arg Gln Asp Asp His Gly Tyr Ile Ser Arg 
            100                 105                 110         


Glu Phe His Arg Arg Tyr Arg Leu Pro Ser Asn Val Asp Gln Ser Ala 
        115                 120                 125             


Leu Ser Cys Ser Leu Ser Ala Asp Gly Met Leu Thr Phe Cys Gly Pro 
    130                 135                 140                 


Lys Ile Gln Thr Gly Leu Asp Ala Thr His Ala Glu Arg Ala Ile Pro 
145                 150                 155                 160 


Val Ser Arg Glu Glu Lys Pro Thr Ser Ala Pro Ser Ser 
                165                 170             


<210>  401
<211>  328
<212>  PRT
<213>  Homo sapiens

<400>  401

Met Lys Thr Cys Trp Lys Ile Pro Val Phe Phe Phe Val Cys Ser Phe 
1               5                   10                  15      


Leu Glu Pro Trp Ala Ser Ala Ala Val Lys Arg Arg Pro Arg Phe Pro 
            20                  25                  30          


Val Asn Ser Asn Ser Asn Gly Gly Asn Glu Leu Cys Pro Lys Ile Arg 
        35                  40                  45              


Ile Gly Gln Asp Asp Leu Pro Gly Phe Asp Leu Ile Ser Gln Phe Gln 
    50                  55                  60                  


Val Asp Lys Ala Ala Ser Arg Arg Ala Ile Gln Arg Val Val Gly Ser 
65                  70                  75                  80  


Ala Thr Leu Gln Val Ala Tyr Lys Leu Gly Asn Asn Val Asp Phe Arg 
                85                  90                  95      


Ile Pro Thr Arg Asn Leu Tyr Pro Ser Gly Leu Pro Glu Glu Tyr Ser 
            100                 105                 110         


Phe Leu Thr Thr Phe Arg Met Thr Gly Ser Thr Leu Lys Lys Asn Trp 
        115                 120                 125             


Asn Ile Trp Gln Ile Gln Asp Ser Ser Gly Lys Glu Gln Val Gly Ile 
    130                 135                 140                 


Lys Ile Asn Gly Gln Thr Gln Ser Val Val Phe Ser Tyr Lys Gly Leu 
145                 150                 155                 160 


Asp Gly Ser Leu Gln Thr Ala Ala Phe Ser Asn Leu Ser Ser Leu Phe 
                165                 170                 175     


Asp Ser Gln Trp His Lys Ile Met Ile Gly Val Glu Arg Ser Ser Ala 
            180                 185                 190         


Thr Leu Phe Val Asp Cys Asn Arg Ile Glu Ser Leu Pro Ile Lys Pro 
        195                 200                 205             


Arg Gly Pro Ile Asp Ile Asp Gly Phe Ala Val Leu Gly Lys Leu Ala 
    210                 215                 220                 


Asp Asn Pro Gln Val Ser Val Pro Phe Glu Leu Gln Trp Met Leu Ile 
225                 230                 235                 240 


His Cys Asp Pro Leu Arg Pro Arg Arg Glu Thr Cys His Glu Leu Pro 
                245                 250                 255     


Ala Arg Ile Thr Pro Ser Gln Thr Thr Asp Glu Arg Gly Pro Pro Gly 
            260                 265                 270         


Glu Gln Gly Pro Pro Gly Pro Pro Gly Pro Pro Gly Val Pro Gly Ile 
        275                 280                 285             


Asp Gly Ile Asp Gly Asp Arg Gly Pro Lys Gly Pro Pro Gly Pro Pro 
    290                 295                 300                 


Gly Pro Ala Gly Glu Pro Gly Lys Pro Gly Ala Pro Gly Lys Pro Gly 
305                 310                 315                 320 


Thr Pro Gly Ala Asp Thr Ser Pro 
                325             


<210>  402
<211>  514
<212>  PRT
<213>  Homo sapiens

<400>  402

Ala Ala Tyr Asn Gly Gly Thr Ser Ala Ala Ala Ala Gly His His His 
1               5                   10                  15      


His His His His His Leu Pro His Leu Pro Pro Pro His Leu His His 
            20                  25                  30          


His His His Pro Gln His His Leu His Pro Gly Ser Ala Ala Ala Val 
        35                  40                  45              


His Pro Val Gln Gln His Thr Ser Ser Ala Ala Ala Ala Ala Ala Ala 
    50                  55                  60                  


Ala Ala Ala Ala Ala Ala Met Leu Asn Pro Gly Gln Gln Gln Pro Tyr 
65                  70                  75                  80  


Phe Pro Ser Pro Ala Pro Gly Gln Ala Pro Gly Pro Ala Ala Ala Ala 
                85                  90                  95      


Pro Ala Gln Val Gln Ala Ala Ala Ala Ala Thr Val Lys Ala His His 
            100                 105                 110         


His Gln His Ser His His Pro Gln Gln Gln Leu Asp Ile Glu Pro Asp 
        115                 120                 125             


Arg Pro Ile Gly Tyr Gly Ala Phe Gly Val Val Trp Ser Val Thr Asp 
    130                 135                 140                 


Pro Arg Asp Gly Lys Arg Val Ala Leu Lys Lys Met Pro Asn Val Phe 
145                 150                 155                 160 


Gln Asn Leu Val Ser Cys Lys Arg Val Phe Arg Glu Leu Lys Met Leu 
                165                 170                 175     


Cys Phe Phe Lys His Asp Asn Val Leu Ser Ala Leu Asp Ile Leu Gln 
            180                 185                 190         


Pro Pro His Ile Asp Tyr Phe Glu Glu Ile Tyr Val Val Thr Glu Leu 
        195                 200                 205             


Met Gln Ser Asp Leu His Lys Ile Ile Val Ser Pro Gln Pro Leu Ser 
    210                 215                 220                 


Ser Asp His Val Lys Val Phe Leu Tyr Gln Ile Leu Arg Gly Leu Lys 
225                 230                 235                 240 


Tyr Leu His Ser Ala Gly Ile Leu His Arg Asp Ile Lys Pro Gly Asn 
                245                 250                 255     


Leu Leu Val Asn Ser Asn Cys Val Leu Lys Ile Cys Asp Phe Gly Leu 
            260                 265                 270         


Ala Arg Val Glu Glu Leu Asp Glu Ser Arg His Met Thr Gln Glu Val 
        275                 280                 285             


Val Thr Gln Tyr Tyr Arg Ala Pro Glu Ile Leu Met Gly Ser Arg His 
    290                 295                 300                 


Tyr Ser Asn Ala Ile Asp Ile Trp Ser Val Gly Cys Ile Phe Ala Glu 
305                 310                 315                 320 


Leu Leu Gly Arg Arg Ile Leu Phe Gln Ala Gln Ser Pro Ile Gln Gln 
                325                 330                 335     


Leu Asp Leu Ile Thr Asp Leu Leu Gly Thr Pro Ser Leu Glu Ala Met 
            340                 345                 350         


Arg Thr Ala Cys Glu Gly Ala Lys Ala His Ile Leu Arg Gly Pro His 
        355                 360                 365             


Lys Gln Pro Ser Leu Pro Val Leu Tyr Thr Leu Ser Ser Gln Ala Thr 
    370                 375                 380                 


His Glu Ala Val His Leu Leu Cys Arg Met Leu Val Phe Asp Pro Ser 
385                 390                 395                 400 


Lys Arg Ile Ser Ala Lys Asp Ala Leu Ala His Pro Tyr Leu Asp Glu 
                405                 410                 415     


Gly Arg Leu Arg Tyr His Thr Cys Met Cys Lys Cys Cys Phe Ser Thr 
            420                 425                 430         


Ser Thr Gly Arg Val Tyr Thr Ser Asp Phe Glu Pro Val Thr Asn Pro 
        435                 440                 445             


Lys Phe Asp Asp Thr Phe Glu Lys Asn Leu Ser Ser Val Arg Gln Val 
    450                 455                 460                 


Lys Glu Ile Ile His Gln Phe Ile Leu Glu Gln Gln Lys Gly Asn Arg 
465                 470                 475                 480 


Val Pro Leu Cys Ile Asn Pro Gln Ser Ala Ala Phe Lys Ser Phe Ile 
                485                 490                 495     


Ser Ser Thr Val Ala Gln Pro Ser Glu Met Pro Pro Ser Pro Leu Val 
            500                 505                 510         


Trp Glu 
        


<210>  403
<211>  552
<212>  PRT
<213>  Homo sapiens

<400>  403

Val Asp Met Gly Ala Leu Asp Asn Leu Ile Ala Asn Thr Ala Tyr Leu 
1               5                   10                  15      


Gln Ala Arg Lys Pro Ser Asp Cys Asp Ser Lys Glu Leu Gln Arg Arg 
            20                  25                  30          


Arg Arg Ser Leu Ala Leu Pro Gly Leu Gln Gly Cys Ala Glu Leu Arg 
        35                  40                  45              


Gln Lys Leu Ser Leu Asn Phe His Ser Leu Cys Glu Gln Gln Pro Ile 
    50                  55                  60                  


Gly Arg Arg Leu Phe Arg Asp Phe Leu Ala Thr Val Pro Thr Phe Arg 
65                  70                  75                  80  


Lys Ala Ala Thr Phe Leu Glu Asp Val Gln Asn Trp Glu Leu Ala Glu 
                85                  90                  95      


Glu Gly Pro Thr Lys Asp Ser Ala Leu Gln Gly Leu Val Ala Thr Cys 
            100                 105                 110         


Ala Ser Ala Pro Ala Pro Gly Asn Pro Gln Pro Phe Leu Ser Gln Ala 
        115                 120                 125             


Val Ala Thr Lys Cys Gln Ala Ala Thr Thr Glu Glu Glu Arg Val Ala 
    130                 135                 140                 


Ala Val Thr Leu Ala Lys Ala Glu Ala Met Ala Phe Leu Gln Glu Gln 
145                 150                 155                 160 


Pro Phe Lys Asp Phe Val Thr Ser Ala Phe Tyr Asp Lys Phe Leu Gln 
                165                 170                 175     


Trp Lys Leu Phe Glu Met Gln Pro Val Ser Asp Lys Tyr Phe Thr Glu 
            180                 185                 190         


Phe Arg Val Leu Gly Lys Gly Gly Phe Gly Glu Val Cys Ala Val Gln 
        195                 200                 205             


Val Lys Asn Thr Gly Lys Met Tyr Ala Cys Lys Lys Leu Asp Lys Lys 
    210                 215                 220                 


Arg Leu Lys Lys Lys Gly Gly Glu Lys Met Ala Leu Leu Glu Lys Glu 
225                 230                 235                 240 


Ile Leu Glu Lys Val Ser Ser Pro Phe Ile Val Ser Leu Ala Tyr Ala 
                245                 250                 255     


Phe Glu Ser Lys Thr His Leu Cys Leu Val Met Ser Leu Met Asn Gly 
            260                 265                 270         


Gly Asp Leu Lys Phe His Ile Tyr Asn Val Gly Thr Arg Gly Leu Asp 
        275                 280                 285             


Met Ser Arg Val Ile Phe Tyr Ser Ala Gln Ile Ala Cys Gly Met Leu 
    290                 295                 300                 


His Leu His Glu Leu Gly Ile Val Tyr Arg Asp Met Lys Pro Glu Asn 
305                 310                 315                 320 


Val Leu Leu Asp Asp Leu Gly Asn Cys Arg Leu Ser Asp Leu Gly Leu 
                325                 330                 335     


Ala Val Glu Met Lys Gly Gly Lys Pro Ile Thr Gln Arg Ala Gly Thr 
            340                 345                 350         


Asn Gly Tyr Met Ala Pro Glu Ile Leu Met Glu Lys Val Ser Tyr Ser 
        355                 360                 365             


Tyr Pro Val Asp Trp Phe Ala Met Gly Cys Ser Ile Tyr Glu Met Val 
    370                 375                 380                 


Ala Gly Arg Thr Pro Phe Lys Asp Tyr Lys Glu Lys Val Ser Lys Glu 
385                 390                 395                 400 


Asp Leu Lys Gln Arg Thr Leu Gln Asp Glu Val Lys Phe Gln His Asp 
                405                 410                 415     


Asn Phe Thr Glu Glu Ala Lys Asp Ile Cys Arg Leu Phe Leu Ala Lys 
            420                 425                 430         


Lys Pro Glu Gln Arg Leu Gly Ser Arg Glu Lys Ser Asp Asp Pro Arg 
        435                 440                 445             


Lys His His Phe Phe Lys Thr Ile Asn Phe Pro Arg Leu Glu Ala Gly 
    450                 455                 460                 


Leu Ile Glu Pro Pro Phe Val Pro Asp Pro Ser Val Val Tyr Ala Lys 
465                 470                 475                 480 


Asp Ile Ala Glu Ile Asp Asp Phe Ser Glu Val Arg Gly Val Glu Phe 
                485                 490                 495     


Asp Asp Lys Asp Lys Gln Phe Phe Lys Asn Phe Ala Thr Gly Ala Val 
            500                 505                 510         


Pro Ile Ala Trp Gln Glu Glu Ile Ile Glu Thr Gly Leu Phe Glu Glu 
        515                 520                 525             


Leu Asn Asp Pro Asn Arg Pro Thr Gly Cys Glu Glu Gly Asn Ser Ser 
    530                 535                 540                 


Lys Ser Gly Val Cys Leu Leu Leu 
545                 550         


<210>  404
<211>  926
<212>  PRT
<213>  Homo sapiens

<400>  404

Met Val Met Ala Asp Gly Pro Arg His Leu Gln Arg Gly Pro Val Arg 
1               5                   10                  15      


Val Gly Phe Tyr Asp Ile Glu Gly Thr Leu Gly Lys Gly Asn Phe Ala 
            20                  25                  30          


Val Val Lys Leu Gly Arg His Arg Ile Thr Lys Thr Glu Val Ala Ile 
        35                  40                  45              


Lys Ile Ile Asp Lys Ser Gln Leu Asp Ala Val Asn Leu Glu Lys Ile 
    50                  55                  60                  


Tyr Arg Glu Val Gln Ile Met Lys Met Leu Asp His Pro His Ile Ile 
65                  70                  75                  80  


Lys Leu Tyr Gln Val Met Glu Thr Lys Ser Met Leu Tyr Leu Val Thr 
                85                  90                  95      


Glu Tyr Ala Lys Asn Gly Glu Ile Phe Asp Tyr Leu Ala Asn His Gly 
            100                 105                 110         


Arg Leu Asn Glu Ser Glu Ala Arg Arg Lys Phe Trp Gln Ile Leu Ser 
        115                 120                 125             


Ala Val Asp Tyr Cys His Gly Arg Lys Ile Val His Arg Asp Leu Lys 
    130                 135                 140                 


Ala Glu Asn Leu Leu Leu Asp Asn Asn Met Asn Ile Lys Ile Ala Asp 
145                 150                 155                 160 


Phe Gly Phe Gly Asn Phe Phe Lys Ser Gly Glu Leu Leu Ala Thr Trp 
                165                 170                 175     


Cys Gly Ser Pro Pro Tyr Ala Ala Pro Glu Val Phe Glu Gly Gln Gln 
            180                 185                 190         


Tyr Glu Gly Pro Gln Leu Asp Ile Trp Ser Met Gly Val Val Leu Tyr 
        195                 200                 205             


Val Leu Val Cys Gly Ala Leu Pro Phe Asp Gly Pro Thr Leu Pro Ile 
    210                 215                 220                 


Leu Arg Gln Arg Val Leu Glu Gly Arg Phe Arg Ile Pro Tyr Phe Met 
225                 230                 235                 240 


Ser Glu Asp Cys Glu His Leu Ile Arg Arg Met Leu Val Leu Asp Pro 
                245                 250                 255     


Ser Lys Arg Leu Thr Ile Ala Gln Ile Lys Glu His Lys Trp Met Leu 
            260                 265                 270         


Ile Glu Val Pro Val Gln Arg Pro Val Leu Tyr Pro Gln Glu Gln Glu 
        275                 280                 285             


Asn Glu Pro Ser Ile Gly Glu Phe Asn Glu Gln Val Leu Arg Leu Met 
    290                 295                 300                 


His Ser Leu Gly Ile Asp Gln Gln Lys Thr Ile Glu Ser Leu Gln Asn 
305                 310                 315                 320 


Lys Ser Tyr Asn His Phe Ala Ala Ile Tyr Phe Leu Leu Val Glu Arg 
                325                 330                 335     


Leu Lys Ser His Arg Ser Ser Phe Pro Val Glu Gln Arg Leu Asp Gly 
            340                 345                 350         


Arg Gln Arg Arg Pro Ser Thr Ile Ala Glu Gln Thr Val Ala Lys Ala 
        355                 360                 365             


Gln Thr Val Gly Leu Pro Val Thr Met His Ser Pro Asn Met Arg Leu 
    370                 375                 380                 


Leu Arg Ser Ala Leu Leu Pro Gln Ala Ser Asn Val Glu Ala Phe Ser 
385                 390                 395                 400 


Phe Pro Ala Ser Gly Cys Gln Ala Glu Ala Ala Phe Met Glu Glu Glu 
                405                 410                 415     


Cys Val Asp Thr Pro Lys Val Asn Gly Cys Leu Leu Asp Pro Val Pro 
            420                 425                 430         


Pro Val Leu Val Arg Lys Gly Cys Gln Ser Leu Pro Ser Asn Met Met 
        435                 440                 445             


Glu Thr Ser Ile Asp Glu Gly Leu Glu Thr Glu Gly Glu Ala Glu Glu 
    450                 455                 460                 


Asp Pro Ala His Ala Phe Glu Ala Phe Gln Ser Thr Arg Ser Gly Gln 
465                 470                 475                 480 


Arg Arg His Thr Leu Ser Glu Val Thr Asn Gln Leu Val Val Met Pro 
                485                 490                 495     


Gly Ala Gly Lys Ile Phe Ser Met Asn Asp Ser Pro Ser Leu Asp Ser 
            500                 505                 510         


Val Asp Ser Glu Tyr Asp Met Gly Ser Val Gln Arg Asp Leu Asn Phe 
        515                 520                 525             


Leu Glu Asp Asn Pro Ser Leu Lys Asp Ile Met Leu Ala Asn Gln Pro 
    530                 535                 540                 


Ser Pro Arg Met Thr Ser Pro Phe Ile Ser Leu Arg Pro Thr Asn Pro 
545                 550                 555                 560 


Ala Met Gln Ala Leu Ser Ser Gln Lys Arg Glu Val His Asn Arg Ser 
                565                 570                 575     


Pro Val Ser Phe Arg Glu Gly Arg Arg Ala Ser Asp Thr Ser Leu Thr 
            580                 585                 590         


Gln Gly Ile Val Ala Phe Arg Gln His Leu Gln Asn Leu Ala Arg Thr 
        595                 600                 605             


Lys Gly Ile Leu Glu Leu Asn Lys Val Gln Leu Leu Tyr Glu Gln Ile 
    610                 615                 620                 


Gly Pro Glu Ala Asp Pro Asn Leu Ala Pro Ala Ala Pro Gln Leu Gln 
625                 630                 635                 640 


Asp Leu Ala Ser Ser Cys Pro Gln Glu Glu Val Ser Gln Gln Gln Glu 
                645                 650                 655     


Ser Val Ser Thr Leu Pro Ala Ser Val His Pro Gln Leu Ser Pro Arg 
            660                 665                 670         


Gln Ser Leu Glu Thr Gln Tyr Leu Gln His Arg Leu Gln Lys Pro Ser 
        675                 680                 685             


Leu Leu Ser Lys Ala Gln Asn Thr Cys Gln Leu Tyr Cys Lys Glu Pro 
    690                 695                 700                 


Pro Arg Ser Leu Glu Gln Gln Leu Gln Glu His Arg Leu Gln Gln Lys 
705                 710                 715                 720 


Arg Leu Phe Leu Gln Lys Gln Ser Gln Leu Gln Ala Tyr Phe Asn Gln 
                725                 730                 735     


Met Gln Ile Ala Glu Ser Ser Tyr Pro Gln Pro Ser Gln Gln Leu Pro 
            740                 745                 750         


Leu Pro Arg Gln Glu Thr Pro Pro Pro Ser Gln Gln Ala Pro Pro Phe 
        755                 760                 765             


Ser Leu Thr Gln Pro Leu Ser Pro Val Leu Glu Pro Ser Ser Glu Gln 
    770                 775                 780                 


Met Gln Tyr Ser Pro Phe Leu Ser Gln Tyr Gln Glu Met Gln Leu Gln 
785                 790                 795                 800 


Pro Leu Pro Ser Thr Ser Gly Pro Arg Ala Ala Pro Pro Leu Pro Thr 
                805                 810                 815     


Gln Leu Gln Gln Gln Gln Pro Pro Pro Pro Pro Pro Pro Pro Pro Pro 
            820                 825                 830         


Arg Gln Pro Gly Ala Ala Pro Ala Pro Leu Gln Phe Ser Tyr Gln Thr 
        835                 840                 845             


Cys Glu Leu Pro Ser Ala Ala Ser Pro Ala Pro Asp Tyr Pro Thr Pro 
    850                 855                 860                 


Cys Gln Tyr Pro Val Asp Gly Ala Gln Gln Ser Asp Leu Thr Gly Pro 
865                 870                 875                 880 


Asp Cys Pro Arg Ser Pro Gly Leu Gln Glu Ala Pro Ser Ser Tyr Asp 
                885                 890                 895     


Pro Leu Ala Leu Ser Glu Leu Pro Gly Leu Phe Asp Cys Glu Met Leu 
            900                 905                 910         


Asp Ala Val Asp Pro Gln His Asn Gly Tyr Val Leu Val Asn 
        915                 920                 925     


<210>  405
<211>  677
<212>  PRT
<213>  Homo sapiens

<400>  405

Met Gln Pro Thr Leu Leu Leu Ser Leu Leu Gly Ala Val Gly Leu Ala 
1               5                   10                  15      


Ala Val Asn Ser Met Pro Val Asp Asn Arg Asn His Asn Glu Gly Met 
            20                  25                  30          


Val Thr Arg Cys Ile Ile Glu Val Leu Ser Asn Ala Leu Ser Lys Ser 
        35                  40                  45              


Ser Ala Pro Pro Ile Thr Pro Glu Cys Arg Gln Val Leu Lys Thr Ser 
    50                  55                  60                  


Arg Lys Asp Val Lys Asp Lys Glu Thr Thr Glu Asn Glu Asn Thr Lys 
65                  70                  75                  80  


Phe Glu Val Arg Leu Leu Arg Asp Pro Ala Asp Ala Ser Glu Ala His 
                85                  90                  95      


Glu Ser Ser Ser Arg Gly Glu Ala Gly Ala Pro Gly Glu Glu Asp Ile 
            100                 105                 110         


Gln Gly Pro Thr Lys Ala Asp Thr Glu Lys Trp Ala Glu Gly Gly Gly 
        115                 120                 125             


His Ser Arg Glu Arg Ala Asp Glu Pro Gln Trp Ser Leu Tyr Pro Ser 
    130                 135                 140                 


Asp Ser Gln Val Ser Glu Glu Val Lys Thr Arg His Ser Glu Lys Ser 
145                 150                 155                 160 


Gln Arg Glu Asp Glu Glu Glu Glu Glu Gly Glu Asn Tyr Gln Lys Gly 
                165                 170                 175     


Glu Arg Gly Glu Asp Ser Ser Glu Glu Lys His Leu Glu Glu Pro Gly 
            180                 185                 190         


Glu Thr Gln Asn Ala Phe Leu Asn Glu Arg Lys Gln Ala Ser Ala Ile 
        195                 200                 205             


Lys Lys Glu Glu Leu Val Ala Arg Ser Glu Thr His Ala Ala Gly His 
    210                 215                 220                 


Ser Gln Glu Lys Thr His Ser Arg Glu Lys Ser Ser Gln Glu Ser Gly 
225                 230                 235                 240 


Glu Glu Ala Gly Ser Gln Glu Asn His Pro Gln Glu Ser Lys Gly Gln 
                245                 250                 255     


Pro Arg Ser Gln Glu Glu Ser Glu Glu Gly Glu Glu Asp Ala Thr Ser 
            260                 265                 270         


Glu Val Asp Lys Arg Arg Thr Arg Pro Arg His His His Gly Arg Ser 
        275                 280                 285             


Arg Pro Asp Arg Ser Ser Gln Gly Gly Ser Leu Pro Ser Glu Glu Lys 
    290                 295                 300                 


Gly His Pro Gln Glu Glu Ser Glu Glu Ser Asn Val Ser Met Ala Ser 
305                 310                 315                 320 


Leu Gly Glu Lys Arg Asp His His Ser Thr His Tyr Arg Ala Ser Glu 
                325                 330                 335     


Glu Glu Pro Glu Tyr Gly Glu Glu Ile Lys Gly Tyr Pro Gly Val Gln 
            340                 345                 350         


Ala Pro Glu Asp Leu Glu Trp Glu Arg Tyr Arg Gly Arg Gly Ser Glu 
        355                 360                 365             


Glu Tyr Arg Ala Pro Arg Pro Gln Ser Glu Glu Ser Trp Asp Glu Glu 
    370                 375                 380                 


Asp Lys Arg Asn Tyr Pro Ser Leu Glu Leu Asp Lys Met Ala His Gly 
385                 390                 395                 400 


Tyr Gly Glu Glu Ser Glu Glu Glu Arg Gly Leu Glu Pro Gly Lys Gly 
                405                 410                 415     


Arg His His Arg Gly Arg Gly Gly Glu Pro Arg Ala Tyr Phe Met Ser 
            420                 425                 430         


Asp Thr Arg Glu Glu Lys Arg Phe Leu Gly Glu Gly His His Arg Val 
        435                 440                 445             


Gln Glu Asn Gln Met Asp Lys Ala Arg Arg His Pro Gln Gly Ala Trp 
    450                 455                 460                 


Lys Glu Leu Asp Arg Asn Tyr Leu Asn Tyr Gly Glu Glu Gly Ala Pro 
465                 470                 475                 480 


Gly Lys Trp Gln Gln Gln Gly Asp Leu Gln Asp Thr Lys Glu Asn Arg 
                485                 490                 495     


Glu Glu Ala Arg Phe Gln Asp Lys Gln Tyr Ser Ser His His Thr Ala 
            500                 505                 510         


Glu Lys Arg Lys Arg Leu Gly Glu Leu Phe Asn Pro Tyr Tyr Asp Pro 
        515                 520                 525             


Leu Gln Trp Lys Ser Ser His Phe Glu Arg Arg Asp Asn Met Asn Asp 
    530                 535                 540                 


Asn Phe Leu Glu Gly Glu Glu Glu Asn Glu Leu Thr Leu Asn Glu Lys 
545                 550                 555                 560 


Asn Phe Phe Pro Glu Tyr Asn Tyr Asp Trp Trp Glu Lys Lys Pro Phe 
                565                 570                 575     


Ser Glu Asp Val Asn Trp Gly Tyr Glu Lys Arg Asn Leu Ala Arg Val 
            580                 585                 590         


Pro Lys Leu Asp Leu Lys Arg Gln Tyr Asp Arg Val Ala Gln Leu Asp 
        595                 600                 605             


Gln Leu Leu His Tyr Arg Lys Lys Ser Ala Glu Phe Pro Asp Phe Tyr 
    610                 615                 620                 


Asp Ser Glu Glu Pro Val Ser Thr His Gln Glu Ala Glu Asn Glu Lys 
625                 630                 635                 640 


Asp Arg Ala Asp Gln Thr Val Leu Thr Glu Asp Glu Lys Lys Glu Leu 
                645                 650                 655     


Glu Asn Leu Ala Ala Met Asp Leu Glu Leu Gln Lys Ile Ala Glu Lys 
            660                 665                 670         


Phe Ser Gln Arg Gly 
        675         


<210>  406
<211>  417
<212>  PRT
<213>  Homo sapiens

<400>  406

Met Asp Arg Glu Thr Arg Ala Leu Ala Asp Ser His Phe Arg Gly Leu 
1               5                   10                  15      


Gly Val Asp Val Pro Gly Val Gly Gln Ala Pro Gly Arg Val Ala Phe 
            20                  25                  30          


Val Ser Glu Pro Gly Ala Phe Ser Tyr Ala Asp Phe Val Arg Gly Phe 
        35                  40                  45              


Leu Leu Pro Asn Leu Pro Cys Val Phe Ser Ser Ala Phe Thr Gln Gly 
    50                  55                  60                  


Trp Gly Ser Arg Arg Arg Trp Val Thr Pro Ala Gly Arg Pro Asp Phe 
65                  70                  75                  80  


Asp His Leu Leu Arg Thr Tyr Gly Asp Val Val Val Pro Val Ala Asn 
                85                  90                  95      


Cys Gly Val Gln Glu Tyr Asn Ser Asn Pro Lys Glu His Met Thr Leu 
            100                 105                 110         


Arg Asp Tyr Ile Thr Tyr Trp Lys Glu Tyr Ile Gln Ala Gly Tyr Ser 
        115                 120                 125             


Ser Pro Arg Gly Cys Leu Tyr Leu Lys Asp Trp His Leu Cys Arg Asp 
    130                 135                 140                 


Phe Pro Val Glu Asp Val Phe Thr Leu Pro Val Tyr Phe Ser Ser Asp 
145                 150                 155                 160 


Trp Leu Asn Glu Phe Trp Asp Ala Leu Asp Val Asp Asp Tyr Arg Phe 
                165                 170                 175     


Val Tyr Ala Gly Pro Ala Gly Ser Trp Ser Pro Phe His Ala Asp Ile 
            180                 185                 190         


Phe Arg Ser Phe Ser Trp Ser Val Asn Val Cys Gly Arg Lys Lys Trp 
        195                 200                 205             


Leu Leu Phe Pro Pro Gly Gln Glu Glu Ala Leu Arg Asp Arg His Gly 
    210                 215                 220                 


Asn Leu Pro Tyr Asp Val Thr Ser Pro Ala Leu Cys Asp Thr His Leu 
225                 230                 235                 240 


His Pro Arg Asn Gln Leu Ala Gly Pro Pro Leu Glu Ile Thr Gln Glu 
                245                 250                 255     


Ala Gly Glu Met Val Phe Val Pro Ser Gly Trp His His Gln Val His 
            260                 265                 270         


Asn Leu Asp Asp Thr Ile Ser Ile Asn His Asn Trp Val Asn Gly Phe 
        275                 280                 285             


Asn Leu Ala Asn Met Trp Arg Phe Leu Gln Gln Glu Leu Cys Ala Val 
    290                 295                 300                 


Gln Glu Glu Val Ser Glu Trp Arg Asp Ser Met Pro Asp Trp His His 
305                 310                 315                 320 


His Cys Gln Val Ile Met Arg Ser Cys Ser Gly Ile Asn Phe Glu Glu 
                325                 330                 335     


Phe Tyr His Phe Leu Lys Val Ile Ala Glu Lys Arg Leu Leu Val Leu 
            340                 345                 350         


Arg Glu Ala Ala Ala Glu Asp Gly Ala Gly Leu Gly Phe Glu Gln Ala 
        355                 360                 365             


Ala Phe Asp Val Gly Arg Ile Thr Glu Val Leu Ala Ser Leu Val Ala 
    370                 375                 380                 


His Pro Asp Phe Gln Arg Val Asp Thr Ser Ala Phe Ser Pro Gln Pro 
385                 390                 395                 400 


Lys Glu Leu Leu Gln Gln Leu Arg Glu Ala Val Asp Ala Ala Ala Ala 
                405                 410                 415     


Pro 
    


<210>  407
<211>  794
<212>  PRT
<213>  Homo sapiens

<400>  407

Asp Thr Lys Leu Asn Met Leu Asn Glu Lys Val Asp Gln Leu Leu His 
1               5                   10                  15      


Phe Gln Glu Asp Val Thr Glu Lys Leu Gln Ser Met Cys Arg Asp Met 
            20                  25                  30          


Gly His Leu Glu Arg Gly Leu His Arg Leu Glu Ala Ser Arg Ala Pro 
        35                  40                  45              


Gly Pro Gly Gly Ala Asp Gly Val Pro His Ile Asp Thr Gln Ala Gly 
    50                  55                  60                  


Trp Pro Glu Val Leu Glu Leu Val Arg Ala Met Gln Gln Asp Ala Ala 
65                  70                  75                  80  


Gln His Gly Ala Arg Leu Glu Ala Leu Phe Arg Met Val Ala Ala Val 
                85                  90                  95      


Asp Arg Ala Ile Ala Leu Val Gly Ala Thr Phe Gln Lys Ser Lys Val 
            100                 105                 110         


Ala Asp Phe Leu Met Gln Gly Arg Val Pro Trp Arg Arg Gly Ser Pro 
        115                 120                 125             


Gly Asp Ser Pro Glu Glu Asn Lys Glu Arg Val Glu Glu Glu Gly Gly 
    130                 135                 140                 


Lys Pro Lys His Val Leu Ser Thr Ser Gly Leu Gln Ser Asp Ala Arg 
145                 150                 155                 160 


Glu Pro Gly Glu Glu Ser Gln Lys Ala Asp Val Leu Glu Gly Thr Ala 
                165                 170                 175     


Glu Arg Leu Pro Pro Ile Arg Ala Ser Gly Leu Gly Ala Asp Pro Ala 
            180                 185                 190         


Gln Ala Val Val Ser Pro Gly Gln Gly Asp Gly Val Pro Gly Pro Ala 
        195                 200                 205             


Gln Ala Phe Pro Gly His Leu Pro Leu Pro Thr Lys Val Glu Ala Lys 
    210                 215                 220                 


Ala Pro Glu Thr Pro Ser Glu Asn Leu Arg Thr Gly Leu Glu Leu Ala 
225                 230                 235                 240 


Pro Ala Pro Gly Arg Val Asn Val Val Ser Pro Ser Leu Glu Val Ala 
                245                 250                 255     


Pro Gly Ala Gly Gln Gly Ala Ser Ser Ser Arg Pro Asp Pro Glu Pro 
            260                 265                 270         


Leu Glu Glu Gly Thr Arg Leu Thr Pro Gly Pro Gly Pro Gln Cys Pro 
        275                 280                 285             


Gly Pro Pro Gly Leu Pro Ala Gln Ala Arg Ala Thr His Ser Gly Gly 
    290                 295                 300                 


Glu Thr Pro Pro Arg Ile Ser Ile His Ile Gln Glu Met Asp Thr Pro 
305                 310                 315                 320 


Gly Glu Met Leu Met Thr Gly Arg Gly Ser Leu Gly Pro Thr Leu Thr 
                325                 330                 335     


Thr Glu Ala Pro Ala Ala Ala Gln Pro Gly Lys Gln Gly Pro Pro Gly 
            340                 345                 350         


Thr Gly Arg Cys Leu Gln Ala Pro Gly Thr Glu Pro Gly Glu Gln Thr 
        355                 360                 365             


Pro Glu Gly Ala Arg Glu Leu Ser Pro Leu Gln Glu Ser Ser Ser Pro 
    370                 375                 380                 


Gly Gly Val Lys Ala Glu Glu Glu Gln Arg Ala Gly Ala Glu Pro Gly 
385                 390                 395                 400 


Thr Arg Pro Ser Leu Ala Arg Ser Asp Asp Asn Asp His Glu Val Gly 
                405                 410                 415     


Ala Leu Gly Leu Gln Gln Gly Lys Ser Pro Gly Ala Gly Asn Pro Glu 
            420                 425                 430         


Pro Glu Gln Asp Cys Ala Ala Arg Ala Pro Val Arg Ala Glu Ala Val 
        435                 440                 445             


Arg Arg Met Pro Pro Gly Ala Glu Ala Gly Ser Val Val Leu Asp Asp 
    450                 455                 460                 


Ser Pro Ala Pro Pro Ala Pro Phe Glu His Arg Val Val Ser Val Lys 
465                 470                 475                 480 


Glu Thr Ser Ile Ser Ala Gly Tyr Glu Val Cys Gln His Glu Val Leu 
                485                 490                 495     


Gly Gly Gly Arg Phe Gly Gln Val His Arg Cys Thr Glu Lys Ser Thr 
            500                 505                 510         


Gly Leu Pro Leu Ala Ala Lys Ile Ile Lys Val Lys Ser Ala Lys Asp 
        515                 520                 525             


Arg Glu Asp Val Lys Asn Glu Ile Asn Ile Met Asn Gln Leu Ser His 
    530                 535                 540                 


Val Asn Leu Ile Gln Leu Tyr Asp Ala Phe Glu Ser Lys His Ser Cys 
545                 550                 555                 560 


Thr Leu Val Met Glu Tyr Val Asp Gly Gly Glu Leu Phe Asp Arg Ile 
                565                 570                 575     


Thr Asp Glu Lys Tyr His Leu Thr Glu Leu Asp Val Val Leu Phe Thr 
            580                 585                 590         


Arg Gln Ile Cys Glu Gly Val His Tyr Leu His Gln His Tyr Ile Leu 
        595                 600                 605             


His Leu Asp Leu Lys Pro Glu Asn Ile Leu Cys Val Asn Gln Thr Gly 
    610                 615                 620                 


His Gln Ile Lys Ile Ile Asp Phe Gly Leu Ala Arg Arg Tyr Lys Pro 
625                 630                 635                 640 


Arg Glu Lys Leu Lys Val Asn Phe Gly Thr Pro Glu Phe Leu Ala Pro 
                645                 650                 655     


Glu Val Val Asn Tyr Glu Phe Val Ser Phe Pro Thr Asp Met Trp Ser 
            660                 665                 670         


Val Gly Val Ile Thr Tyr Met Leu Leu Ser Gly Leu Ser Pro Phe Leu 
        675                 680                 685             


Gly Glu Thr Asp Ala Glu Thr Met Asn Phe Ile Val Asn Cys Ser Trp 
    690                 695                 700                 


Asp Phe Asp Ala Asp Thr Phe Glu Gly Leu Ser Glu Glu Ala Lys Asp 
705                 710                 715                 720 


Phe Val Ser Arg Leu Leu Val Lys Glu Lys Ser Cys Arg Met Ser Ala 
                725                 730                 735     


Thr Gln Cys Leu Lys His Glu Trp Leu Asn Asn Leu Pro Ala Lys Ala 
            740                 745                 750         


Ser Arg Ser Lys Thr Arg Leu Lys Ser Gln Leu Leu Leu Gln Lys Tyr 
        755                 760                 765             


Ile Ala Gln Arg Lys Trp Lys Lys His Phe Tyr Val Val Thr Ala Ala 
    770                 775                 780                 


Asn Arg Leu Arg Lys Phe Pro Thr Ser Pro 
785                 790                 


<210>  408
<211>  265
<212>  PRT
<213>  Homo sapiens

<400>  408

Met Ala Glu Ala Gly Thr Gly Leu Leu Pro Ala Thr Val Gln Pro Phe 
1               5                   10                  15      


His Leu Arg Gly Met Ser Ser Thr Phe Ser Gln Arg Ser Arg Asp Ile 
            20                  25                  30          


Phe Asp Cys Leu Glu Gly Ala Ala Arg Arg Ala Pro Ser Ser Val Ala 
        35                  40                  45              


His Thr Ser Met Ser Asp Asn Gly Gly Phe Lys Arg Pro Leu Ala Pro 
    50                  55                  60                  


Ser Gly Arg Ser Pro Val Glu Gly Leu Gly Arg Ala His Arg Ser Pro 
65                  70                  75                  80  


Ala Ser Pro Arg Val Pro Pro Val Pro Asp Tyr Val Ala His Pro Glu 
                85                  90                  95      


Arg Trp Thr Lys Tyr Ser Leu Glu Asp Val Thr Glu Val Ser Glu Gln 
            100                 105                 110         


Ser Asn Gln Ala Thr Ala Leu Ala Phe Leu Gly Ser Gln Ser Leu Ala 
        115                 120                 125             


Ala Pro Thr Asp Cys Val Ser Ser Phe Asn Gln Asp Pro Ser Ser Cys 
    130                 135                 140                 


Gly Glu Gly Arg Val Ile Phe Thr Lys Pro Val Arg Gly Val Glu Ala 
145                 150                 155                 160 


Arg His Glu Arg Lys Arg Val Leu Gly Lys Val Gly Glu Pro Gly Arg 
                165                 170                 175     


Gly Gly Leu Gly Asn Pro Ala Thr Asp Arg Gly Glu Gly Pro Val Glu 
            180                 185                 190         


Leu Ala His Leu Ala Gly Pro Gly Ser Pro Glu Ala Glu Glu Trp Gly 
        195                 200                 205             


Ser Pro His Gly Gly Leu Gln Glu Val Glu Ala Leu Ser Gly Ser Val 
    210                 215                 220                 


His Ser Gly Ser Val Pro Gly Leu Pro Pro Val Glu Thr Val Gly Phe 
225                 230                 235                 240 


His Gly Ser Arg Lys Arg Ser Arg Asp His Phe Arg Asn Lys Ser Ser 
                245                 250                 255     


Ser Pro Glu Asp Pro Gly Ala Glu Val 
            260                 265 


<210>  409
<211>  399
<212>  PRT
<213>  Homo sapiens

<400>  409

Met Gln Leu Lys Lys Glu Thr Ile Glu Glu Lys Lys Asp Arg Met Arg 
1               5                   10                  15      


Glu Lys Thr Lys Leu Leu Lys Glu Lys Asn Glu Lys Glu Arg Gln Asp 
            20                  25                  30          


Phe Val Ala Glu Lys Leu Asp Gln Gln Phe Arg Glu Arg Cys Glu Glu 
        35                  40                  45              


Leu Arg Val Glu Leu Leu Ser Ile His Gln Lys Lys Val Cys Glu Glu 
    50                  55                  60                  


Arg Lys Ala Gln Ile Ala Phe Asn Glu Glu Leu Ser Arg Gln Lys Leu 
65                  70                  75                  80  


Val Glu Glu Gln Met Phe Ser Lys Leu Trp Glu Glu Asp Arg Leu Ala 
                85                  90                  95      


Lys Glu Lys Arg Glu Ala Gln Glu Ala Arg Arg Gln Lys Glu Leu Met 
            100                 105                 110         


Glu Asn Thr Arg Leu Gly Leu Asn Ala Gln Ile Thr Ser Ile Lys Ala 
        115                 120                 125             


Gln Arg Gln Ala Thr Gln Leu Leu Lys Glu Glu Glu Ala Arg Leu Val 
    130                 135                 140                 


Glu Ser Asn Asn Ala Gln Ile Lys His Glu Asn Glu Gln Asp Met Leu 
145                 150                 155                 160 


Lys Lys Gln Lys Ala Lys Gln Glu Thr Arg Thr Ile Leu Gln Lys Ala 
                165                 170                 175     


Leu Gln Glu Arg Ile Glu His Ile Gln Gln Glu Tyr Arg Asp Glu Gln 
            180                 185                 190         


Asp Leu Asn Met Lys Leu Val Gln Arg Ala Leu Gln Asp Leu Gln Glu 
        195                 200                 205             


Glu Ala Asp Lys Lys Lys Gln Lys Arg Glu Asp Met Ile Arg Glu Gln 
    210                 215                 220                 


Lys Ile Tyr His Lys Tyr Leu Ala Gln Arg Arg Glu Glu Glu Lys Ala 
225                 230                 235                 240 


Gln Glu Lys Glu Phe Asp Arg Ile Leu Glu Glu Asp Lys Ala Lys Lys 
                245                 250                 255     


Leu Ala Glu Lys Asp Lys Glu Leu Arg Leu Glu Lys Glu Ala Arg Arg 
            260                 265                 270         


Gln Leu Val Asp Glu Val Met Cys Thr Arg Lys Leu Gln Val Gln Glu 
        275                 280                 285             


Lys Leu Gln Arg Glu Ala Lys Glu Gln Glu Glu Arg Ala Met Glu Gln 
    290                 295                 300                 


Lys His Ile Asn Glu Ser Leu Lys Glu Leu Asn Cys Glu Glu Lys Glu 
305                 310                 315                 320 


Asn Phe Ala Arg Arg Gln Arg Leu Ala Gln Glu Tyr Arg Lys Gln Leu 
                325                 330                 335     


Gln Met Gln Ile Ala Tyr Gln Gln Gln Ser Gln Glu Ala Glu Lys Glu 
            340                 345                 350         


Glu Lys Arg Arg Glu Phe Glu Ala Gly Val Ala Ala Asn Lys Met Cys 
        355                 360                 365             


Leu Asp Lys Val Gln Glu Val Leu Ser Thr His Gln Val Leu Pro Gln 
    370                 375                 380                 


Asn Ile His Pro Met Arg Lys Ala Cys Pro Ser Lys Leu Pro Pro 
385                 390                 395                 


<210>  410
<211>  241
<212>  PRT
<213>  Homo sapiens

<400>  410

Lys Lys Ala Gly Ser Ala Ala Ala Pro Phe Thr Pro Ala Lys Lys Pro 
1               5                   10                  15      


Leu Thr Lys Ile Val Ser Tyr Leu Leu Val Ala Glu Pro Asp Lys Leu 
            20                  25                  30          


Tyr Ala Met Pro Pro Pro Gly Met Pro Glu Gly Asp Ile Lys Ala Leu 
        35                  40                  45              


Thr Thr Leu Cys Asp Leu Ala Asp Arg Glu Leu Val Val Ile Ile Gly 
    50                  55                  60                  


Trp Ala Lys His Ile Pro Gly Phe Ser Ser Leu Ser Leu Gly Asp Gln 
65                  70                  75                  80  


Met Ser Leu Leu Gln Ser Ala Trp Met Glu Ile Leu Ile Leu Gly Ile 
                85                  90                  95      


Val Tyr Arg Ser Leu Pro Tyr Asp Asp Lys Leu Val Tyr Ala Glu Asp 
            100                 105                 110         


Tyr Ile Met Asp Glu Glu His Ser Arg Leu Ala Gly Leu Leu Glu Leu 
        115                 120                 125             


Tyr Arg Ala Ile Leu Gln Leu Val Arg Arg Tyr Lys Lys Leu Lys Val 
    130                 135                 140                 


Glu Lys Glu Glu Phe Val Thr Leu Lys Ala Leu Ala Leu Ala Asn Ser 
145                 150                 155                 160 


Asp Ser Met Tyr Ile Glu Asp Leu Glu Ala Val Gln Lys Leu Gln Asp 
                165                 170                 175     


Leu Leu His Glu Ala Leu Gln Asp Tyr Glu Leu Ser Gln Arg His Glu 
            180                 185                 190         


Glu Pro Trp Arg Thr Gly Lys Leu Leu Leu Thr Leu Pro Leu Leu Arg 
        195                 200                 205             


Gln Thr Ala Ala Lys Ala Val Gln His Phe Tyr Ser Val Lys Leu Gln 
    210                 215                 220                 


Gly Lys Val Pro Met His Lys Leu Phe Leu Glu Met Leu Glu Ala Lys 
225                 230                 235                 240 


Val 
    


<210>  411
<211>  571
<212>  PRT
<213>  Homo sapiens

<400>  411

His Asn Gln Thr Ser Leu Tyr Lys Lys Ala Gly Ser Ala Ala Ala Val 
1               5                   10                  15      


Leu Glu Glu Asn Leu Tyr Phe Gln Gly Ser Phe Thr Met Arg Arg Arg 
            20                  25                  30          


His Ile Val Arg Lys Arg Thr Leu Arg Arg Leu Leu Gln Glu Arg Glu 
        35                  40                  45              


Leu Val Glu Pro Leu Thr Pro Ser Gly Glu Ala Pro Asn Gln Ala Leu 
    50                  55                  60                  


Leu Arg Ile Leu Lys Glu Thr Glu Phe Lys Lys Ile Lys Val Leu Gly 
65                  70                  75                  80  


Ser Gly Ala Phe Gly Thr Val Tyr Lys Gly Leu Trp Ile Pro Glu Gly 
                85                  90                  95      


Glu Lys Val Lys Ile Pro Val Ala Ile Lys Glu Leu Arg Glu Ala Thr 
            100                 105                 110         


Ser Pro Lys Ala Asn Lys Glu Ile Leu Asp Glu Ala Tyr Val Met Ala 
        115                 120                 125             


Ser Val Asp Asn Pro His Val Cys Arg Leu Leu Gly Ile Cys Leu Thr 
    130                 135                 140                 


Ser Thr Val Gln Leu Ile Thr Gln Leu Met Pro Phe Gly Cys Leu Leu 
145                 150                 155                 160 


Asp Tyr Val Arg Glu His Lys Asp Asn Ile Gly Ser Gln Tyr Leu Leu 
                165                 170                 175     


Asn Trp Cys Val Gln Ile Ala Lys Gly Met Asn Tyr Leu Glu Asp Arg 
            180                 185                 190         


Arg Leu Val His Arg Asp Leu Ala Ala Arg Asn Val Leu Val Lys Thr 
        195                 200                 205             


Pro Gln His Val Lys Ile Thr Asp Phe Gly Arg Ala Lys Leu Leu Gly 
    210                 215                 220                 


Ala Glu Glu Lys Glu Tyr His Ala Glu Gly Gly Lys Val Pro Ile Lys 
225                 230                 235                 240 


Trp Met Ala Leu Glu Ser Ile Leu His Arg Ile Tyr Thr His Gln Ser 
                245                 250                 255     


Asp Val Trp Ser Tyr Gly Val Thr Val Trp Glu Leu Met Thr Phe Gly 
            260                 265                 270         


Ser Lys Pro Tyr Asp Gly Ile Pro Ala Ser Glu Ile Ser Ser Ile Leu 
        275                 280                 285             


Glu Lys Gly Glu Arg Leu Pro Gln Pro Pro Ile Cys Thr Ile Asp Val 
    290                 295                 300                 


Tyr Met Ile Met Val Lys Cys Trp Met Ile Asp Ala Asp Ser Arg Pro 
305                 310                 315                 320 


Lys Phe Arg Glu Leu Ile Ile Glu Phe Ser Lys Met Ala Arg Asp Pro 
                325                 330                 335     


Gln Arg Tyr Leu Val Ile Gln Gly Asp Glu Arg Met His Leu Pro Ser 
            340                 345                 350         


Pro Thr Asp Ser Asn Phe Tyr Arg Ala Leu Met Asp Glu Glu Asp Met 
        355                 360                 365             


Asp Asp Val Val Asp Ala Asp Glu Tyr Leu Ile Pro Gln Gln Gly Phe 
    370                 375                 380                 


Phe Ser Ser Pro Ser Thr Ser Arg Thr Pro Leu Leu Ser Ser Leu Ser 
385                 390                 395                 400 


Ala Thr Ser Asn Asn Ser Thr Val Ala Cys Ile Asp Arg Asn Gly Leu 
                405                 410                 415     


Gln Ser Cys Pro Ile Lys Glu Asp Ser Phe Leu Gln Arg Tyr Ser Ser 
            420                 425                 430         


Asp Pro Thr Gly Ala Leu Thr Glu Asp Ser Ile Asp Asp Thr Phe Leu 
        435                 440                 445             


Pro Val Pro Glu Tyr Ile Asn Gln Ser Val Pro Lys Arg Pro Ala Gly 
    450                 455                 460                 


Ser Val Gln Asn Pro Val Tyr His Asn Gln Pro Leu Asn Pro Ala Pro 
465                 470                 475                 480 


Ser Arg Asp Pro His Tyr Gln Asp Pro His Ser Thr Ala Val Gly Asn 
                485                 490                 495     


Pro Glu Tyr Leu Asn Thr Val Gln Pro Thr Cys Val Asn Ser Thr Phe 
            500                 505                 510         


Asp Ser Pro Ala His Trp Ala Gln Lys Gly Ser His Gln Ile Ser Leu 
        515                 520                 525             


Asp Asn Pro Asp Tyr Gln Gln Asp Phe Phe Pro Lys Glu Ala Lys Pro 
    530                 535                 540                 


Asn Gly Ile Phe Lys Gly Ser Thr Ala Glu Asn Ala Glu Tyr Leu Arg 
545                 550                 555                 560 


Val Ala Pro Gln Ser Ser Glu Phe Ile Gly Ala 
                565                 570     


<210>  412
<211>  360
<212>  PRT
<213>  Homo sapiens

<400>  412

Met Val Thr Leu Glu Glu Phe Leu Glu Glu Ser Asn Arg Ser Ser Pro 
1               5                   10                  15      


Thr His Asp Thr Pro Ser Cys Arg Asp Asp Leu Leu Ser Asp Tyr Phe 
            20                  25                  30          


Arg Lys Ala Ser Asp Pro Pro Ala Ile Gly Gly Gln Pro Gly Pro Pro 
        35                  40                  45              


Ala Lys Lys Glu Gly Ala Lys Met Pro Thr Asn Phe Val Ala Pro Thr 
    50                  55                  60                  


Val Lys Met Ala Ala Pro Thr Ser Glu Gly Arg Pro Leu Lys Pro Gly 
65                  70                  75                  80  


Gln Tyr Val Lys Pro Asn Phe Arg Leu Thr Glu Ala Glu Ala Pro Pro 
                85                  90                  95      


Ser Val Ala Pro Arg Gln Ala Gln Pro Pro Gln Ser Leu Ser Leu Gly 
            100                 105                 110         


Arg Pro Arg Gln Ala Pro Val Pro Pro Ala Ser His Ala Pro Ala Ser 
        115                 120                 125             


Arg Ser Ala Ser Leu Ser Arg Ala Phe Ser Leu Ala Ser Ala Asp Leu 
    130                 135                 140                 


Leu Arg Ala Ser Gly Pro Glu Ala Cys Lys Gln Glu Ser Pro Gln Lys 
145                 150                 155                 160 


Leu Gly Ala Pro Glu Ala Leu Gly Gly Arg Glu Thr Gly Ser His Thr 
                165                 170                 175     


Leu Gln Ser Pro Ala Pro Pro Ser Ser His Ser Leu Ala Arg Glu Arg 
            180                 185                 190         


Thr Pro Leu Val Gly Lys Ala Gly Ser Ser Cys Gln Gly Pro Gly Pro 
        195                 200                 205             


Arg Ser Arg Pro Leu Asp Thr Arg Arg Phe Ser Leu Ala Pro Pro Lys 
    210                 215                 220                 


Glu Glu Arg Leu Ala Pro Leu His Gln Ser Ala Thr Ala Pro Ala Ile 
225                 230                 235                 240 


Ala Thr Ala Gly Ala Gly Ala Ala Ala Ala Gly Ser Gly Ser Asn Ser 
                245                 250                 255     


Gln Leu Leu His Phe Ser Pro Ala Ala Ala Pro Ala Ala Arg Thr Lys 
            260                 265                 270         


Pro Lys Ala Pro Pro Arg Ser Gly Glu Val Ala Thr Ile Thr Pro Val 
        275                 280                 285             


Arg Ala Gly Leu Ser Leu Ser Glu Gly Asp Gly Val Pro Gly Gln Gly 
    290                 295                 300                 


Cys Ser Glu Gly Leu Pro Ala Lys Ser Pro Gly Arg Ser Pro Asp Leu 
305                 310                 315                 320 


Ala Pro His Pro Gly Arg Ala Leu Glu Asp Cys Ser Arg Gly Ser Val 
                325                 330                 335     


Ser Lys Ser Ser Pro Ala Ser Pro Glu Pro Gly Gly Asp Pro Gln Thr 
            340                 345                 350         


Val Trp Tyr Glu Tyr Gly Cys Val 
        355                 360 


<210>  413
<211>  801
<212>  PRT
<213>  Homo sapiens

<400>  413

Met Glu Ser Arg Ala Glu Gly Gly Ser Pro Ala Val Phe Asp Trp Phe 
1               5                   10                  15      


Phe Glu Ala Ala Cys Pro Ala Ser Leu Gln Glu Asp Pro Pro Ile Leu 
            20                  25                  30          


Arg Gln Phe Pro Pro Asp Phe Arg Asp Gln Glu Ala Met Gln Met Val 
        35                  40                  45              


Pro Lys Phe Cys Phe Pro Phe Asp Val Glu Arg Glu Pro Pro Ser Pro 
    50                  55                  60                  


Ala Val Gln His Phe Thr Phe Ala Leu Thr Asp Leu Ala Gly Asn Arg 
65                  70                  75                  80  


Arg Phe Gly Phe Cys Arg Leu Arg Ala Gly Thr Gln Ser Cys Leu Cys 
                85                  90                  95      


Ile Leu Ser His Leu Pro Trp Phe Glu Val Phe Tyr Lys Leu Leu Asn 
            100                 105                 110         


Thr Val Gly Asp Leu Leu Ala Gln Asp Gln Val Thr Glu Ala Glu Glu 
        115                 120                 125             


Leu Leu Gln Asn Leu Phe Gln Gln Ser Leu Ser Gly Pro Gln Ala Ser 
    130                 135                 140                 


Val Gly Leu Glu Leu Gly Ser Gly Val Thr Val Ser Ser Gly Gln Gly 
145                 150                 155                 160 


Ile Pro Pro Pro Thr Arg Gly Asn Ser Lys Pro Leu Ser Cys Phe Val 
                165                 170                 175     


Ala Pro Asp Ser Gly Arg Leu Pro Ser Ile Pro Glu Asn Arg Asn Leu 
            180                 185                 190         


Thr Glu Leu Val Val Ala Val Thr Asp Glu Asn Ile Val Gly Leu Phe 
        195                 200                 205             


Ala Ala Leu Leu Ala Glu Arg Arg Val Leu Leu Thr Ala Ser Lys Leu 
    210                 215                 220                 


Ser Thr Leu Thr Ser Cys Val His Ala Ser Cys Ala Leu Leu Tyr Pro 
225                 230                 235                 240 


Met Arg Trp Glu His Val Leu Ile Pro Thr Leu Pro Pro His Leu Leu 
                245                 250                 255     


Asp Tyr Cys Cys Ala Pro Met Pro Tyr Leu Ile Gly Val His Ala Ser 
            260                 265                 270         


Leu Ala Glu Arg Val Arg Glu Lys Ala Leu Glu Asp Val Val Val Leu 
        275                 280                 285             


Asn Val Asp Ala Asn Thr Leu Glu Thr Thr Phe Asn Asp Val Gln Ala 
    290                 295                 300                 


Leu Pro Pro Asp Val Val Ser Leu Leu Arg Leu Arg Leu Arg Lys Val 
305                 310                 315                 320 


Ala Leu Ala Pro Gly Glu Gly Val Ser Arg Leu Phe Leu Lys Ala Gln 
                325                 330                 335     


Ala Leu Leu Phe Gly Gly Tyr Arg Asp Ala Leu Val Cys Ser Pro Gly 
            340                 345                 350         


Gln Pro Val Thr Phe Ser Glu Glu Val Phe Leu Ala Gln Lys Pro Gly 
        355                 360                 365             


Ala Pro Leu Gln Ala Phe His Arg Arg Ala Val His Leu Gln Leu Phe 
    370                 375                 380                 


Lys Gln Phe Ile Glu Ala Arg Leu Glu Lys Leu Asn Lys Gly Glu Gly 
385                 390                 395                 400 


Phe Ser Asp Gln Phe Glu Gln Glu Ile Thr Gly Cys Gly Ala Ser Ser 
                405                 410                 415     


Gly Ala Leu Arg Ser Tyr Gln Leu Trp Ala Asp Asn Leu Lys Lys Gly 
            420                 425                 430         


Gly Gly Ala Leu Leu His Ser Val Lys Ala Lys Thr Gln Pro Ala Val 
        435                 440                 445             


Lys Asn Met Tyr Arg Ser Ala Lys Ser Gly Leu Lys Gly Val Gln Ser 
    450                 455                 460                 


Leu Leu Met Tyr Lys Asp Gly Asp Ser Val Leu Gln Arg Gly Gly Ser 
465                 470                 475                 480 


Leu Arg Ala Pro Ala Leu Pro Ser Arg Ser Asp Arg Leu Gln Gln Arg 
                485                 490                 495     


Leu Pro Ile Thr Gln His Phe Gly Lys Asn Arg Pro Leu Arg Pro Ser 
            500                 505                 510         


Arg Arg Arg Gln Leu Glu Glu Gly Thr Ser Glu Pro Pro Gly Ala Gly 
        515                 520                 525             


Thr Pro Pro Leu Ser Pro Glu Asp Glu Gly Cys Pro Trp Ala Glu Glu 
    530                 535                 540                 


Ala Leu Asp Ser Ser Phe Leu Gly Ser Gly Glu Glu Leu Asp Leu Leu 
545                 550                 555                 560 


Ser Glu Ile Leu Asp Ser Leu Ser Met Gly Ala Lys Ser Ala Gly Ser 
                565                 570                 575     


Leu Arg Pro Ser Gln Ser Leu Asp Cys Cys His Arg Gly Asp Leu Asp 
            580                 585                 590         


Ser Cys Phe Ser Leu Pro Asn Ile Pro Arg Trp Gln Pro Asp Asp Lys 
        595                 600                 605             


Lys Leu Pro Glu Pro Glu Pro Gln Pro Leu Ser Leu Pro Ser Leu Gln 
    610                 615                 620                 


Asn Ala Ser Ser Leu Asp Ala Thr Ser Ser Ser Lys Asp Ser Arg Ser 
625                 630                 635                 640 


Gln Leu Ile Pro Ser Glu Ser Asp Gln Glu Val Thr Ser Pro Ser Gln 
                645                 650                 655     


Ser Ser Thr Ala Ser Ala Asp Pro Ser Ile Trp Gly Asp Pro Lys Pro 
            660                 665                 670         


Ser Pro Leu Thr Glu Pro Leu Ile Leu His Leu Thr Pro Ser His Lys 
        675                 680                 685             


Ala Ala Glu Asp Ser Thr Ala Gln Glu Asn Pro Thr Pro Trp Leu Ser 
    690                 695                 700                 


Thr Ala Pro Thr Glu Pro Ser Pro Pro Glu Ser Pro Gln Ile Leu Ala 
705                 710                 715                 720 


Pro Thr Lys Pro Asn Phe Asp Ile Ala Trp Thr Ser Gln Pro Leu Asp 
                725                 730                 735     


Pro Ser Ser Asp Pro Ser Ser Leu Glu Asp Pro Arg Ala Arg Pro Pro 
            740                 745                 750         


Lys Ala Leu Leu Ala Glu Arg Ala His Leu Gln Pro Arg Glu Glu Pro 
        755                 760                 765             


Gly Ala Leu Asn Ser Pro Ala Thr Pro Thr Ser Asn Cys Gln Lys Ser 
    770                 775                 780                 


Gln Pro Ser Ser Arg Pro Arg Val Ala Asp Leu Lys Lys Cys Phe Glu 
785                 790                 795                 800 


Gly 
    


<210>  414
<211>  222
<212>  PRT
<213>  Homo sapiens

<400>  414

Met Ala Ala Thr Ala Val Ala Ala Ala Val Ala Gly Thr Glu Ser Ala 
1               5                   10                  15      


Gln Gly Pro Pro Gly Pro Ala Ala Ser Leu Glu Leu Trp Leu Asn Lys 
            20                  25                  30          


Ala Thr Asp Pro Ser Met Ser Glu Gln Asp Trp Ser Ala Ile Gln Asn 
        35                  40                  45              


Phe Cys Glu Gln Val Asn Thr Asp Pro Asn Gly Pro Thr His Ala Pro 
    50                  55                  60                  


Trp Leu Leu Ala His Lys Ile Gln Ser Pro Gln Glu Lys Glu Ala Leu 
65                  70                  75                  80  


Tyr Ala Leu Thr Val Leu Glu Met Cys Met Asn His Cys Gly Glu Lys 
                85                  90                  95      


Phe His Ser Glu Val Ala Lys Phe Arg Phe Leu Asn Glu Leu Ile Lys 
            100                 105                 110         


Val Leu Ser Pro Lys Tyr Leu Gly Ser Trp Ala Thr Gly Lys Val Lys 
        115                 120                 125             


Gly Arg Val Ile Glu Ile Leu Phe Ser Trp Thr Val Trp Phe Pro Glu 
    130                 135                 140                 


Asp Ile Lys Ile Arg Asp Ala Tyr Gln Met Leu Lys Lys Gln Gly Ile 
145                 150                 155                 160 


Ile Lys Gln Asp Pro Lys Leu Pro Val Asp Lys Ile Leu Pro Pro Pro 
                165                 170                 175     


Ser Pro Trp Pro Lys Ser Ser Ile Phe Asp Ala Asp Glu Glu Lys Ser 
            180                 185                 190         


Lys Leu Phe Leu Ser Ala Ser Glu Pro Gly Pro Ile His Phe Pro Ser 
        195                 200                 205             


Thr Met Asn Ser Pro Asn Arg Tyr Ser Leu Asp Ile Ser Ile 
    210                 215                 220         


<210>  415
<211>  269
<212>  PRT
<213>  Homo sapiens

<400>  415

Met Ala Ile Asn Arg Phe Arg Leu Glu Asn Asp Leu Glu Glu Leu Ala 
1               5                   10                  15      


Leu Tyr Gln Ile Gln Leu Leu Lys Asp Leu Arg His Thr Glu Asn Glu 
            20                  25                  30          


Glu Asp Lys Val Ser Ser Ser Ser Phe Arg Gln Arg Met Leu Gly Asn 
        35                  40                  45              


Leu Leu Arg Pro Pro Tyr Glu Arg Pro Glu Leu Pro Thr Cys Leu Tyr 
    50                  55                  60                  


Val Ile Gly Leu Thr Gly Ile Ser Gly Ser Gly Lys Ser Ser Ile Ala 
65                  70                  75                  80  


Gln Arg Leu Lys Gly Leu Gly Ala Phe Val Ile Asp Ser Asp His Leu 
                85                  90                  95      


Gly His Arg Ala Tyr Ala Pro Gly Gly Pro Ala Tyr Gln Pro Val Val 
            100                 105                 110         


Glu Ala Phe Gly Thr Asp Ile Leu His Lys Asp Gly Ile Ile Asn Arg 
        115                 120                 125             


Lys Val Leu Gly Ser Arg Val Phe Gly Asn Lys Lys Gln Leu Lys Ile 
    130                 135                 140                 


Leu Thr Asp Ile Met Trp Pro Ile Ile Ala Lys Leu Ala Arg Glu Glu 
145                 150                 155                 160 


Met Asp Arg Ala Val Ala Glu Gly Lys Arg Val Cys Val Ile Asp Ala 
                165                 170                 175     


Ala Val Leu Leu Glu Ala Gly Trp Gln Asn Leu Val His Glu Val Trp 
            180                 185                 190         


Thr Ala Val Ile Pro Glu Thr Glu Ala Val Arg Arg Ile Val Glu Arg 
        195                 200                 205             


Asp Gly Leu Ser Glu Ala Ala Ala Gln Ser Arg Leu Gln Ser Gln Met 
    210                 215                 220                 


Ser Gly Gln Gln Leu Val Glu Gln Ser His Val Val Leu Ser Thr Leu 
225                 230                 235                 240 


Trp Glu Pro His Ile Thr Gln Arg Gln Val Glu Lys Ala Trp Ala Leu 
                245                 250                 255     


Leu Gln Lys Arg Ile Pro Lys Thr His Gln Ala Leu Asp 
            260                 265                 


<210>  416
<211>  246
<212>  PRT
<213>  Homo sapiens

<400>  416

Met Arg Asn Met Leu Ser Lys Leu Gln Ile Ala Cys Asp Asn Ala Val 
1               5                   10                  15      


Phe Gly Cys Ser Ala Val Val Arg Leu Asp Asn Leu Met Ser His Leu 
            20                  25                  30          


Ser Asp Cys Glu His Asn Pro Lys Arg Pro Val Thr Cys Glu Gln Gly 
        35                  40                  45              


Cys Gly Leu Glu Met Pro Lys Asp Glu Leu Pro Asn His Asn Cys Ile 
    50                  55                  60                  


Lys His Leu Arg Ser Val Val Gln Gln Gln Gln Thr Arg Ile Ala Glu 
65                  70                  75                  80  


Leu Glu Lys Thr Ser Ala Glu His Lys His Gln Leu Ala Glu Gln Lys 
                85                  90                  95      


Arg Asp Ile Gln Leu Leu Lys Ala Tyr Met Arg Ala Ile Arg Ser Val 
            100                 105                 110         


Asn Pro Asn Leu Gln Asn Leu Glu Glu Thr Ile Glu Tyr Asn Glu Ile 
        115                 120                 125             


Leu Glu Trp Val Asn Ser Leu Gln Pro Ala Arg Val Thr Arg Trp Gly 
    130                 135                 140                 


Gly Met Ile Ser Thr Pro Asp Ala Val Leu Gln Ala Val Ile Lys Arg 
145                 150                 155                 160 


Ser Leu Val Glu Ser Gly Cys Pro Ala Ser Ile Val Asn Glu Leu Ile 
                165                 170                 175     


Glu Asn Ala His Glu Arg Ser Trp Pro Gln Gly Leu Ala Thr Leu Glu 
            180                 185                 190         


Thr Arg Gln Met Asn Arg Arg Tyr Tyr Glu Asn Tyr Val Ala Lys Arg 
        195                 200                 205             


Ile Pro Gly Lys Gln Ala Val Val Val Met Ala Cys Glu Asn Gln His 
    210                 215                 220                 


Met Gly Asp Asp Met Val Gln Glu Pro Gly Leu Val Met Ile Phe Ala 
225                 230                 235                 240 


His Gly Val Glu Glu Ile 
                245     


<210>  417
<211>  83
<212>  PRT
<213>  Homo sapiens

<400>  417

Met Ser Phe Phe Gln Leu Leu Met Lys Arg Lys Glu Leu Ile Pro Leu 
1               5                   10                  15      


Val Val Phe Met Thr Val Ala Ala Gly Gly Ala Ser Ser Phe Ala Val 
            20                  25                  30          


Tyr Ser Leu Trp Lys Thr Asp Val Ile Leu Asp Arg Lys Lys Asn Pro 
        35                  40                  45              


Glu Pro Trp Glu Thr Val Asp Pro Thr Val Pro Gln Lys Leu Ile Thr 
    50                  55                  60                  


Ile Asn Gln Gln Trp Lys Pro Ile Glu Glu Leu Gln Asn Val Gln Arg 
65                  70                  75                  80  


Val Thr Lys 
            


<210>  418
<211>  571
<212>  PRT
<213>  Homo sapiens

<400>  418

His Asn Gln Thr Ser Leu Tyr Lys Lys Ala Gly Ser Ala Ala Ala Val 
1               5                   10                  15      


Leu Glu Glu Asn Leu Tyr Phe Gln Gly Ser Phe Thr Met Arg Arg Arg 
            20                  25                  30          


His Ile Val Arg Lys Arg Thr Leu Arg Arg Leu Leu Gln Glu Arg Glu 
        35                  40                  45              


Leu Val Glu Pro Leu Thr Pro Ser Gly Glu Ala Pro Asn Gln Ala Leu 
    50                  55                  60                  


Leu Arg Ile Leu Lys Glu Thr Glu Phe Lys Lys Ile Lys Val Leu Gly 
65                  70                  75                  80  


Ser Gly Ala Phe Gly Thr Val Tyr Lys Gly Leu Trp Ile Pro Glu Gly 
                85                  90                  95      


Glu Lys Val Lys Ile Pro Val Ala Ile Lys Glu Leu Arg Glu Ala Thr 
            100                 105                 110         


Ser Pro Lys Ala Asn Lys Glu Ile Leu Asp Glu Ala Tyr Val Met Ala 
        115                 120                 125             


Ser Val Asp Asn Pro His Val Cys Arg Leu Leu Gly Ile Cys Leu Thr 
    130                 135                 140                 


Ser Thr Val Gln Leu Ile Thr Gln Leu Met Pro Phe Gly Cys Leu Leu 
145                 150                 155                 160 


Asp Tyr Val Arg Glu His Lys Asp Asn Ile Gly Ser Gln Tyr Leu Leu 
                165                 170                 175     


Asn Trp Cys Val Gln Ile Ala Lys Gly Met Asn Tyr Leu Glu Asp Arg 
            180                 185                 190         


Arg Leu Val His Arg Asp Leu Ala Ala Arg Asn Val Leu Val Lys Thr 
        195                 200                 205             


Pro Gln His Val Lys Ile Thr Asp Phe Gly Leu Ala Lys Gln Leu Gly 
    210                 215                 220                 


Ala Glu Glu Lys Glu Tyr His Ala Glu Gly Gly Lys Val Pro Ile Lys 
225                 230                 235                 240 


Trp Met Ala Leu Glu Ser Ile Leu His Arg Ile Tyr Thr His Gln Ser 
                245                 250                 255     


Asp Val Trp Ser Tyr Gly Val Thr Val Trp Glu Leu Met Thr Phe Gly 
            260                 265                 270         


Ser Lys Pro Tyr Asp Gly Ile Pro Ala Ser Glu Ile Ser Ser Ile Leu 
        275                 280                 285             


Glu Lys Gly Glu Arg Leu Pro Gln Pro Pro Ile Cys Thr Ile Asp Val 
    290                 295                 300                 


Tyr Met Ile Met Val Lys Cys Trp Met Ile Asp Ala Asp Ser Arg Pro 
305                 310                 315                 320 


Lys Phe Arg Glu Leu Ile Ile Glu Phe Ser Lys Met Ala Arg Asp Pro 
                325                 330                 335     


Gln Arg Tyr Leu Val Ile Gln Gly Asp Glu Arg Met His Leu Pro Ser 
            340                 345                 350         


Pro Thr Asp Ser Asn Phe Tyr Arg Ala Leu Met Asp Glu Glu Asp Met 
        355                 360                 365             


Asp Asp Val Val Asp Ala Asp Glu Tyr Leu Ile Pro Gln Gln Gly Phe 
    370                 375                 380                 


Phe Ser Ser Pro Ser Thr Ser Arg Thr Pro Leu Leu Ser Ser Leu Ser 
385                 390                 395                 400 


Ala Thr Ser Asn Asn Ser Thr Val Ala Cys Ile Asp Arg Asn Gly Leu 
                405                 410                 415     


Gln Ser Cys Pro Ile Lys Glu Asp Ser Phe Leu Gln Arg Tyr Ser Ser 
            420                 425                 430         


Asp Pro Thr Gly Ala Leu Thr Glu Asp Ser Ile Asp Asp Thr Phe Leu 
        435                 440                 445             


Pro Val Pro Glu Tyr Ile Asn Gln Ser Val Pro Lys Arg Pro Ala Gly 
    450                 455                 460                 


Ser Val Gln Asn Pro Val Tyr His Asn Gln Pro Leu Asn Pro Ala Pro 
465                 470                 475                 480 


Ser Arg Asp Pro His Tyr Gln Asp Pro His Ser Thr Ala Val Gly Asn 
                485                 490                 495     


Pro Glu Tyr Leu Asn Thr Val Gln Pro Thr Cys Val Asn Ser Thr Phe 
            500                 505                 510         


Asp Ser Pro Ala His Trp Ala Gln Lys Gly Ser His Gln Ile Ser Leu 
        515                 520                 525             


Asp Asn Pro Asp Tyr Gln Gln Asp Phe Phe Pro Lys Glu Ala Lys Pro 
    530                 535                 540                 


Asn Gly Ile Phe Lys Gly Ser Thr Ala Glu Asn Ala Glu Tyr Leu Arg 
545                 550                 555                 560 


Val Ala Pro Gln Ser Ser Glu Phe Ile Gly Ala 
                565                 570     


<210>  419
<211>  359
<212>  PRT
<213>  Homo sapiens

<400>  419

Met Ile Ala Ala Gln Ala Lys Leu Val Tyr Gln Leu Asn Lys Tyr Tyr 
1               5                   10                  15      


Thr Glu Arg Cys Gln Ala Arg Lys Ala Ala Ile Ala Lys Thr Ile Arg 
            20                  25                  30          


Glu Val Cys Lys Val Val Ser Asp Val Leu Lys Glu Val Glu Val Gln 
        35                  40                  45              


Glu Pro Arg Phe Ile Ser Ser Leu Ser Glu Ile Asp Ala Arg Tyr Glu 
    50                  55                  60                  


Gly Leu Glu Val Ile Ser Pro Thr Glu Phe Glu Val Val Leu Tyr Leu 
65                  70                  75                  80  


Asn Gln Met Gly Val Phe Asn Phe Val Asp Asp Gly Ser Leu Pro Gly 
                85                  90                  95      


Cys Ala Val Leu Lys Leu Ser Asp Gly Arg Lys Arg Ser Met Ser Leu 
            100                 105                 110         


Trp Val Glu Phe Ile Thr Ala Ser Gly Tyr Leu Ser Ala Arg Lys Ile 
        115                 120                 125             


Arg Ser Arg Phe Gln Thr Leu Val Ala Gln Ala Val Asp Lys Cys Ser 
    130                 135                 140                 


Tyr Arg Asp Val Val Lys Met Ile Ala Asp Thr Ser Glu Val Lys Leu 
145                 150                 155                 160 


Arg Ile Arg Glu Arg Tyr Val Val Gln Ile Thr Pro Ala Phe Lys Cys 
                165                 170                 175     


Thr Gly Ile Trp Pro Arg Ser Ala Ala Gln Trp Pro Met Pro His Ile 
            180                 185                 190         


Pro Trp Pro Gly Pro Asn Arg Val Ala Glu Val Lys Ala Glu Gly Phe 
        195                 200                 205             


Asn Leu Leu Ser Lys Glu Cys Tyr Ser Leu Thr Gly Lys Gln Ser Ser 
    210                 215                 220                 


Ala Glu Ser Asp Ala Trp Val Leu Gln Phe Gly Glu Ala Glu Asn Arg 
225                 230                 235                 240 


Leu Leu Met Gly Gly Cys Arg Asn Lys Cys Leu Ser Val Leu Lys Thr 
                245                 250                 255     


Leu Arg Asp Arg His Leu Glu Leu Pro Gly Gln Pro Leu Asn Asn Tyr 
            260                 265                 270         


His Met Lys Thr Leu Leu Leu Tyr Glu Cys Glu Lys His Pro Arg Glu 
        275                 280                 285             


Thr Asp Trp Asp Glu Ser Cys Leu Gly Asp Arg Leu Asn Gly Ile Leu 
    290                 295                 300                 


Leu Gln Leu Ile Ser Cys Leu Gln Cys Arg Arg Cys Pro His Tyr Phe 
305                 310                 315                 320 


Leu Pro Asn Leu Asp Leu Phe Gln Gly Lys Pro His Ser Ala Leu Glu 
                325                 330                 335     


Ser Ala Ala Lys Gln Thr Trp Arg Leu Ala Arg Glu Ile Leu Thr Asn 
            340                 345                 350         


Pro Lys Ser Leu Asp Lys Leu 
        355                 


<210>  420
<211>  380
<212>  PRT
<213>  Homo sapiens

<400>  420

Met Glu Glu Ile Tyr Ala Lys Phe Val Ser Gln Lys Ile Ser Lys Thr 
1               5                   10                  15      


Arg Trp Arg Pro Leu Pro Pro Gly Ser Leu Gln Thr Ala Glu Thr Phe 
            20                  25                  30          


Ala Thr Gly Ser Trp Asp Asn Glu Glu Asn Tyr Ile Ser Leu Trp Ser 
        35                  40                  45              


Ile Gly Asp Phe Gly Asn Leu Asp Ser Asp Gly Gly Phe Glu Gly Asp 
    50                  55                  60                  


His Gln Leu Leu Cys Asp Ile Arg His His Gly Asp Val Met Asp Leu 
65                  70                  75                  80  


Gln Phe Phe Asp Gln Glu Arg Ile Val Ala Ala Ser Ser Thr Gly Cys 
                85                  90                  95      


Val Thr Val Phe Leu His His Pro Asn Asn Gln Thr Leu Ser Val Asn 
            100                 105                 110         


Gln Gln Trp Thr Thr Ala His Tyr His Thr Gly Pro Gly Ser Pro Ser 
        115                 120                 125             


Tyr Ser Ser Ala Pro Cys Thr Gly Val Val Cys Asn Asn Pro Glu Ile 
    130                 135                 140                 


Val Thr Val Gly Glu Asp Gly Arg Ile Asn Leu Phe Arg Ala Asp His 
145                 150                 155                 160 


Lys Glu Ala Val Arg Thr Ile Asp Asn Ala Asp Ser Ser Thr Leu His 
                165                 170                 175     


Ala Val Thr Phe Leu Arg Thr Pro Glu Ile Leu Thr Val Asn Ser Ile 
            180                 185                 190         


Gly Gln Leu Lys Ile Trp Asp Phe Arg Gln Gln Gly Asn Glu Pro Ser 
        195                 200                 205             


Gln Ile Leu Ser Leu Thr Gly Asp Arg Val Pro Leu His Cys Val Asp 
    210                 215                 220                 


Arg His Pro Asn Gln Gln His Val Val Ala Thr Gly Gly Gln Asp Gly 
225                 230                 235                 240 


Met Leu Ser Ile Trp Asp Val Arg Gln Gly Thr Met Pro Val Ser Leu 
                245                 250                 255     


Leu Lys Ala His Glu Ala Glu Met Trp Glu Val His Phe His Pro Ser 
            260                 265                 270         


Asn Pro Glu His Leu Phe Thr Cys Ser Glu Asp Gly Ser Leu Trp His 
        275                 280                 285             


Trp Asp Ala Ser Thr Asp Val Pro Glu Lys Ser Ser Leu Phe His Gln 
    290                 295                 300                 


Gly Gly Arg Ser Ser Thr Phe Leu Ser His Ser Ile Ser Asn Gln Ala 
305                 310                 315                 320 


Asn Val His Gln Ser Val Ile Ser Ser Trp Leu Ser Thr Asp Pro Ala 
                325                 330                 335     


Lys Asp Arg Ile Glu Ile Thr Ser Leu Leu Pro Ser Arg Ser Leu Ser 
            340                 345                 350         


Val Asn Thr Leu Asp Val Leu Gly Pro Cys Leu Val Cys Gly Thr Asp 
        355                 360                 365             


Ala Glu Ala Ile Tyr Val Thr Arg His Leu Phe Ser 
    370                 375                 380 


<210>  421
<211>  142
<212>  PRT
<213>  Homo sapiens

<400>  421

Met Ser Leu Thr Lys Thr Glu Arg Thr Ile Ile Val Ser Met Trp Ala 
1               5                   10                  15      


Lys Ile Ser Thr Gln Ala Asp Thr Ile Gly Thr Glu Thr Leu Glu Arg 
            20                  25                  30          


Leu Phe Leu Ser His Pro Gln Thr Lys Thr Tyr Phe Pro His Phe Asp 
        35                  40                  45              


Leu His Pro Gly Ser Ala Gln Leu Arg Ala His Gly Ser Lys Val Val 
    50                  55                  60                  


Ala Ala Val Gly Asp Ala Val Lys Ser Ile Asp Asp Ile Gly Gly Ala 
65                  70                  75                  80  


Leu Ser Lys Leu Ser Glu Leu His Ala Tyr Ile Leu Arg Val Asp Pro 
                85                  90                  95      


Val Asn Phe Lys Leu Leu Ser His Cys Leu Leu Val Thr Leu Ala Ala 
            100                 105                 110         


Arg Phe Pro Ala Asp Phe Thr Ala Glu Ala His Ala Ala Trp Asp Lys 
        115                 120                 125             


Phe Leu Ser Val Val Ser Ser Val Leu Thr Glu Lys Tyr Arg 
    130                 135                 140         


<210>  422
<211>  467
<212>  PRT
<213>  Homo sapiens

<400>  422

Met Ala Leu His Pro Arg Arg Val Arg Leu Lys Pro Trp Leu Val Ala 
1               5                   10                  15      


Gln Val Asp Ser Gly Leu Tyr Pro Gly Leu Ile Trp Leu His Arg Asp 
            20                  25                  30          


Ser Lys Arg Phe Gln Ile Pro Trp Lys His Ala Thr Arg His Ser Pro 
        35                  40                  45              


Gln Gln Glu Glu Glu Asn Thr Ile Phe Lys Ala Trp Ala Val Glu Thr 
    50                  55                  60                  


Gly Lys Tyr Gln Glu Gly Val Asp Asp Pro Asp Pro Ala Lys Trp Lys 
65                  70                  75                  80  


Ala Gln Leu Arg Cys Ala Leu Asn Lys Ser Arg Glu Phe Asn Leu Met 
                85                  90                  95      


Tyr Asp Gly Thr Lys Glu Val Pro Met Asn Pro Val Lys Ile Tyr Gln 
            100                 105                 110         


Val Cys Asp Ile Pro Gln Pro Gln Gly Ser Ile Ile Asn Pro Gly Ser 
        115                 120                 125             


Thr Gly Ser Ala Pro Trp Asp Glu Lys Asp Asn Asp Val Asp Glu Glu 
    130                 135                 140                 


Asp Glu Glu Asp Glu Leu Asp Gln Ser Gln His His Val Pro Ile Gln 
145                 150                 155                 160 


Asp Thr Phe Pro Phe Leu Asn Ile Asn Gly Ser Pro Met Ala Pro Ala 
                165                 170                 175     


Ser Val Gly Asn Cys Ser Val Gly Asn Cys Ser Pro Glu Ala Val Trp 
            180                 185                 190         


Pro Lys Thr Glu Pro Leu Glu Met Glu Val Pro Gln Ala Pro Ile Gln 
        195                 200                 205             


Pro Phe Tyr Ser Ser Pro Glu Leu Trp Ile Ser Ser Leu Pro Met Thr 
    210                 215                 220                 


Asp Leu Asp Ile Lys Phe Gln Tyr Arg Gly Lys Glu Tyr Gly Gln Thr 
225                 230                 235                 240 


Met Thr Val Ser Asn Pro Gln Gly Cys Arg Leu Phe Tyr Gly Asp Leu 
                245                 250                 255     


Gly Pro Met Pro Asp Gln Glu Glu Leu Phe Gly Pro Val Ser Leu Glu 
            260                 265                 270         


Gln Val Lys Phe Pro Gly Pro Glu His Ile Thr Asn Glu Lys Gln Lys 
        275                 280                 285             


Leu Phe Thr Ser Lys Leu Leu Asp Val Met Asp Arg Gly Leu Ile Leu 
    290                 295                 300                 


Glu Val Ser Gly His Ala Ile Tyr Ala Ile Arg Leu Cys Gln Cys Lys 
305                 310                 315                 320 


Val Tyr Trp Ser Gly Pro Cys Ala Pro Ser Leu Val Ala Pro Asn Leu 
                325                 330                 335     


Ile Glu Arg Gln Lys Lys Val Lys Leu Phe Cys Leu Glu Thr Phe Leu 
            340                 345                 350         


Ser Asp Leu Ile Ala His Gln Lys Gly Gln Ile Glu Lys Gln Pro Pro 
        355                 360                 365             


Phe Glu Ile Tyr Leu Cys Phe Gly Glu Glu Trp Pro Asp Gly Lys Pro 
    370                 375                 380                 


Leu Glu Arg Lys Leu Ile Leu Val Gln Val Ile Pro Val Val Ala Arg 
385                 390                 395                 400 


Met Ile Tyr Glu Met Phe Ser Gly Asp Phe Thr Arg Ser Phe Asp Ser 
                405                 410                 415     


Gly Ser Val Arg Leu Gln Ile Ser Thr Pro Asp Ile Lys Asp Asn Ile 
            420                 425                 430         


Val Ala Gln Leu Lys Gln Leu Tyr Arg Ile Leu Gln Thr Gln Glu Ser 
        435                 440                 445             


Trp Gln Pro Met Gln Pro Thr Pro Ser Met Gln Leu Pro Pro Ala Leu 
    450                 455                 460                 


Pro Pro Gln 
465         


<210>  423
<211>  117
<212>  PRT
<213>  Homo sapiens

<400>  423

Met Pro Leu Pro Pro Cys Val Val Ser Thr Leu Gln Asp Phe Ile Leu 
1               5                   10                  15      


Gly His Pro Lys Ala Glu Asp Ile Ala Gly Gln Gln Glu Ile His Gly 
            20                  25                  30          


Ala Ser Arg Lys Thr Ser Lys Arg Trp Trp Ser Arg Gly Arg His Thr 
        35                  40                  45              


Gln Thr Ala Val Cys Asn Cys Ala Ala Ala Gly Cys Cys Gly Cys Trp 
    50                  55                  60                  


Pro Ala Val His Ser Gly His Thr Gly Leu Cys His Arg Met Gln Ala 
65                  70                  75                  80  


Val Ala Gly Gly Gly Thr Ala Gly Arg Gln Gly Leu Cys Ala Trp Lys 
                85                  90                  95      


Pro Ala Gly Leu Leu Gln Glu Glu Gly Cys Arg Met Leu Gln Leu Arg 
            100                 105                 110         


Pro Asp Ser Gly Phe 
        115         


<210>  424
<211>  348
<212>  PRT
<213>  Homo sapiens

<400>  424

Met Ala Glu Lys Val Leu Val Thr Gly Gly Ala Gly Tyr Ile Gly Ser 
1               5                   10                  15      


His Thr Val Leu Glu Leu Leu Glu Ala Gly Tyr Leu Pro Val Val Ile 
            20                  25                  30          


Asp Asn Phe His Asn Ala Phe Arg Gly Gly Gly Ser Leu Pro Glu Ser 
        35                  40                  45              


Leu Arg Arg Val Gln Glu Leu Thr Gly Arg Ser Val Glu Phe Glu Glu 
    50                  55                  60                  


Met Asp Ile Leu Asp Gln Gly Ala Leu Gln Arg Leu Phe Lys Lys Tyr 
65                  70                  75                  80  


Ser Phe Met Ala Val Ile His Phe Ala Gly Leu Lys Ala Val Gly Glu 
                85                  90                  95      


Ser Val Gln Lys Pro Leu Asp Tyr Tyr Arg Val Asn Leu Thr Gly Thr 
            100                 105                 110         


Ile Gln Leu Leu Glu Ile Met Lys Ala His Gly Val Lys Asn Leu Val 
        115                 120                 125             


Phe Ser Ser Ser Ala Thr Val Tyr Gly Asn Pro Gln Tyr Leu Pro Leu 
    130                 135                 140                 


Asp Glu Ala His Pro Thr Gly Gly Cys Thr Asn Pro Tyr Gly Lys Ser 
145                 150                 155                 160 


Lys Phe Phe Ile Glu Glu Met Ile Arg Asp Leu Cys Gln Ala Asp Lys 
                165                 170                 175     


Thr Trp Asn Ala Val Leu Leu Arg Tyr Phe Asn Pro Thr Gly Ala His 
            180                 185                 190         


Ala Ser Gly Cys Ile Gly Glu Asp Pro Gln Gly Ile Pro Asn Asn Leu 
        195                 200                 205             


Met Pro Tyr Val Ser Gln Val Ala Ile Gly Arg Arg Glu Ala Leu Asn 
    210                 215                 220                 


Val Phe Gly Asn Asp Tyr Asp Thr Glu Asp Gly Thr Gly Val Arg Asp 
225                 230                 235                 240 


Tyr Ile His Val Val Asp Leu Ala Lys Gly His Ile Ala Ala Leu Arg 
                245                 250                 255     


Lys Leu Lys Glu Gln Cys Gly Cys Arg Ile Tyr Asn Leu Gly Thr Gly 
            260                 265                 270         


Thr Gly Tyr Ser Val Leu Gln Met Val Gln Ala Met Glu Lys Ala Ser 
        275                 280                 285             


Gly Lys Lys Ile Pro Tyr Lys Val Val Ala Arg Arg Glu Gly Asp Val 
    290                 295                 300                 


Ala Ala Cys Tyr Ala Asn Pro Ser Leu Ala Gln Glu Glu Leu Gly Trp 
305                 310                 315                 320 


Thr Ala Ala Leu Gly Leu Asp Arg Met Cys Glu Asp Leu Trp Arg Trp 
                325                 330                 335     


Gln Lys Gln Asn Pro Ser Gly Phe Gly Thr Gln Ala 
            340                 345             


<210>  425
<211>  186
<212>  PRT
<213>  Homo sapiens

<400>  425

Met Ala Gly Glu Asn Phe Ala Thr Pro Phe His Gly His Val Gly Arg 
1               5                   10                  15      


Gly Ala Phe Ser Asp Val Tyr Glu Pro Ala Glu Asp Thr Phe Leu Leu 
            20                  25                  30          


Leu Asp Ala Leu Glu Ala Ala Ala Ala Glu Leu Ala Gly Val Glu Ile 
        35                  40                  45              


Cys Leu Glu Val Gly Ser Gly Ser Gly Val Val Ser Ala Phe Leu Ala 
    50                  55                  60                  


Ser Met Ile Gly Pro Gln Ala Leu Tyr Met Cys Thr Asp Ile Asn Pro 
65                  70                  75                  80  


Glu Ala Ala Ala Cys Thr Leu Glu Thr Ala Arg Cys Asn Lys Val His 
                85                  90                  95      


Ile Gln Pro Val Ile Thr Asp Leu Val Gly Ser His Gly Ile Glu Ala 
            100                 105                 110         


Ala Trp Ala Gly Gly Arg Asn Gly Arg Glu Val Met Asp Arg Phe Phe 
        115                 120                 125             


Pro Leu Val Pro Asp Leu Leu Ser Pro Arg Gly Leu Phe Tyr Leu Val 
    130                 135                 140                 


Thr Ile Lys Glu Asn Asn Pro Glu Glu Ile Leu Lys Ile Met Lys Thr 
145                 150                 155                 160 


Lys Gly Leu Gln Gly Thr Thr Ala Leu Ser Arg Gln Ala Gly Gln Glu 
                165                 170                 175     


Thr Leu Ser Val Leu Lys Phe Thr Lys Ser 
            180                 185     


<210>  426
<211>  471
<212>  PRT
<213>  Homo sapiens

<400>  426

Met Lys Gly Asn Tyr Glu Ser Leu Ile Ser Met Asp Tyr Ala Ile Asn 
1               5                   10                  15      


Gln Pro Asp Val Leu Ser Gln Ile Gln Pro Glu Gly Glu His Asn Thr 
            20                  25                  30          


Glu Asp Gln Ala Gly Pro Glu Glu Ser Glu Ile Pro Thr Asp Pro Ser 
        35                  40                  45              


Glu Glu Pro Gly Ile Ser Thr Ser Asp Ile Leu Ser Trp Ile Lys Gln 
    50                  55                  60                  


Glu Glu Glu Pro Gln Val Gly Ala Pro Pro Glu Ser Lys Glu Ser Asp 
65                  70                  75                  80  


Val Tyr Lys Ser Thr Tyr Ala Asp Glu Glu Leu Val Ile Lys Ala Glu 
                85                  90                  95      


Gly Leu Ala Arg Ser Ser Leu Cys Pro Glu Val Pro Val Pro Phe Ser 
            100                 105                 110         


Ser Pro Pro Ala Ala Ala Lys Asp Ala Phe Ser Asp Val Ala Phe Lys 
        115                 120                 125             


Ser Gln Gln Ser Thr Ser Met Thr Pro Phe Gly Arg Pro Ala Thr Asp 
    130                 135                 140                 


Leu Pro Glu Ala Ser Glu Gly Gln Val Thr Phe Thr Gln Leu Gly Ser 
145                 150                 155                 160 


Tyr Pro Leu Pro Pro Pro Val Gly Glu Gln Val Phe Ser Cys His His 
                165                 170                 175     


Cys Gly Lys Asn Leu Ser Gln Asp Met Leu Leu Thr His Gln Cys Ser 
            180                 185                 190         


His Ala Thr Glu His Pro Leu Pro Cys Ala Gln Cys Pro Lys His Phe 
        195                 200                 205             


Thr Pro Gln Ala Asp Leu Ser Ser Thr Ser Gln Asp His Ala Ser Glu 
    210                 215                 220                 


Thr Pro Pro Thr Cys Pro His Cys Ala Arg Thr Phe Thr His Pro Ser 
225                 230                 235                 240 


Arg Leu Thr Tyr His Leu Arg Val His Asn Ser Thr Glu Arg Pro Phe 
                245                 250                 255     


Pro Cys Pro Asp Cys Pro Lys Arg Phe Ala Asp Gln Ala Arg Leu Thr 
            260                 265                 270         


Ser His Arg Arg Ala His Ala Ser Glu Arg Pro Phe Arg Cys Ala Gln 
        275                 280                 285             


Cys Gly Arg Ser Phe Ser Leu Lys Ile Ser Leu Leu Leu His Gln Arg 
    290                 295                 300                 


Gly His Ala Gln Glu Arg Pro Phe Ser Cys Pro Gln Cys Gly Ile Asp 
305                 310                 315                 320 


Phe Asn Gly His Ser Ala Leu Ile Arg His Gln Met Ile His Thr Gly 
                325                 330                 335     


Glu Arg Pro Tyr Pro Cys Thr Asp Cys Ser Lys Ser Phe Met Arg Lys 
            340                 345                 350         


Glu His Leu Leu Asn His Arg Arg Leu His Thr Gly Glu Arg Pro Phe 
        355                 360                 365             


Ser Cys Pro His Cys Gly Lys Ser Phe Ile Arg Lys His His Leu Met 
    370                 375                 380                 


Lys His Gln Arg Ile His Thr Gly Glu Arg Pro Tyr Pro Cys Ser Tyr 
385                 390                 395                 400 


Cys Gly Arg Ser Phe Arg Tyr Lys Gln Thr Leu Lys Asp His Leu Arg 
                405                 410                 415     


Ser Gly His Asn Gly Gly Cys Gly Gly Asp Ser Asp Pro Ser Gly Gln 
            420                 425                 430         


Pro Pro Asn Pro Pro Gly Pro Leu Ile Thr Gly Leu Glu Thr Ser Gly 
        435                 440                 445             


Leu Gly Val Asn Thr Glu Gly Leu Glu Thr Asn Gln Trp Tyr Gly Glu 
    450                 455                 460                 


Gly Ser Gly Gly Gly Val Leu 
465                 470     


<210>  427
<211>  331
<212>  PRT
<213>  Homo sapiens

<400>  427

Met Ser Gly Glu Asn Val Thr Arg Val Gly Thr Phe Ile Leu Val Gly 
1               5                   10                  15      


Phe Pro Thr Ala Pro Gly Leu Gln Tyr Leu Leu Phe Leu Leu Phe Leu 
            20                  25                  30          


Leu Thr Tyr Leu Phe Val Leu Val Glu Asn Leu Ala Ile Ile Leu Thr 
        35                  40                  45              


Val Trp Ser Ser Thr Ser Leu His Arg Pro Met Tyr Tyr Phe Leu Ser 
    50                  55                  60                  


Ser Met Ser Phe Leu Glu Ile Trp Tyr Val Ser Asp Ile Thr Pro Lys 
65                  70                  75                  80  


Met Leu Glu Gly Phe Leu Leu Gln Gln Lys Arg Ile Ser Phe Val Gly 
                85                  90                  95      


Cys Met Thr Gln Leu Tyr Phe Phe Ser Ser Leu Val Cys Thr Glu Cys 
            100                 105                 110         


Val Leu Leu Ala Ser Met Ala Tyr Asp Arg Tyr Val Ala Ile Cys His 
        115                 120                 125             


Pro Leu Arg Tyr His Val Leu Val Thr Pro Gly Leu Cys Leu Gln Leu 
    130                 135                 140                 


Val Gly Phe Ser Phe Val Ser Gly Phe Thr Ile Ser Met Ile Lys Val 
145                 150                 155                 160 


Cys Phe Ile Ser Ser Val Thr Phe Cys Gly Ser Asn Val Leu Asn His 
                165                 170                 175     


Phe Phe Cys Asp Ile Ser Pro Ile Leu Lys Leu Ala Cys Thr Asp Phe 
            180                 185                 190         


Ser Thr Ala Glu Leu Val Asp Phe Ile Leu Ala Phe Ile Ile Leu Val 
        195                 200                 205             


Phe Pro Leu Leu Ala Thr Met Leu Ser Tyr Ala His Ile Thr Leu Ala 
    210                 215                 220                 


Val Leu Arg Ile Pro Ser Ala Thr Gly Cys Trp Arg Ala Phe Phe Thr 
225                 230                 235                 240 


Cys Ala Ser His Leu Thr Val Val Thr Val Phe Tyr Thr Ala Leu Leu 
                245                 250                 255     


Phe Met Tyr Val Arg Pro Gln Ala Ile Asp Ser Arg Ser Ser Asn Lys 
            260                 265                 270         


Leu Ile Ser Val Leu Tyr Thr Val Ile Thr Pro Ile Leu Asn Pro Leu 
        275                 280                 285             


Ile Tyr Cys Leu Arg Asn Lys Glu Phe Lys Asn Ala Leu Lys Lys Ala 
    290                 295                 300                 


Phe Gly Leu Thr Ser Cys Ala Val Glu Gly Arg Leu Ser Ser Leu Leu 
305                 310                 315                 320 


Glu Leu His Leu Gln Ile His Ser Gln Pro Leu 
                325                 330     


<210>  428
<211>  675
<212>  PRT
<213>  Homo sapiens

<400>  428

Met Ala Pro Phe Leu Arg Ile Ala Phe Asn Ser Tyr Glu Leu Gly Ser 
1               5                   10                  15      


Leu Gln Ala Glu Asp Glu Ala Asn Gln Pro Phe Cys Ala Val Lys Met 
            20                  25                  30          


Lys Glu Ala Leu Ser Thr Glu Arg Gly Lys Thr Leu Val Gln Lys Lys 
        35                  40                  45              


Pro Thr Met Tyr Pro Glu Trp Lys Ser Thr Phe Asp Ala His Ile Tyr 
    50                  55                  60                  


Glu Gly Arg Val Ile Gln Ile Val Leu Met Arg Ala Ala Glu Glu Pro 
65                  70                  75                  80  


Val Ser Glu Val Thr Val Gly Val Ser Val Leu Ala Glu Arg Cys Lys 
                85                  90                  95      


Lys Asn Asn Gly Lys Ala Glu Phe Trp Leu Asp Leu Gln Pro Gln Ala 
            100                 105                 110         


Lys Val Leu Met Ser Val Gln Tyr Phe Leu Glu Asp Val Asp Cys Lys 
        115                 120                 125             


Gln Ser Met Arg Ser Glu Asp Glu Ala Lys Phe Pro Thr Met Asn Arg 
    130                 135                 140                 


Arg Gly Ala Ile Lys Gln Ala Lys Ile His Tyr Ile Lys Asn His Glu 
145                 150                 155                 160 


Phe Ile Ala Thr Phe Phe Gly Gln Pro Thr Phe Cys Ser Val Cys Lys 
                165                 170                 175     


Asp Phe Val Trp Gly Leu Asn Lys Gln Gly Tyr Lys Cys Arg Gln Cys 
            180                 185                 190         


Asn Ala Ala Ile His Lys Lys Cys Ile Asp Lys Ile Ile Ser Arg Cys 
        195                 200                 205             


Thr Gly Thr Ala Ala Asn Ser Arg Asp Thr Ile Phe Gln Lys Glu Arg 
    210                 215                 220                 


Phe Asn Ile Asp Met Pro His Arg Phe Lys Val His Asn Tyr Met Ser 
225                 230                 235                 240 


Pro Thr Phe Cys Asp His Cys Gly Ser Leu Leu Trp Gly Leu Val Lys 
                245                 250                 255     


Gln Gly Leu Lys Cys Glu Asp Cys Gly Met Asn Val His His Lys Cys 
            260                 265                 270         


Arg Glu Lys Val Ala Asn Leu Cys Gly Ile Asn Gln Lys Leu Leu Ala 
        275                 280                 285             


Glu Ala Leu Asn Gln Val Thr Gln Arg Ala Ser Arg Arg Ser Asp Ser 
    290                 295                 300                 


Ala Ser Ser Glu Pro Val Gly Ile Tyr Gln Gly Phe Glu Lys Lys Thr 
305                 310                 315                 320 


Gly Val Ala Gly Glu Asp Met Gln Asp Asn Ser Gly Thr Tyr Gly Lys 
                325                 330                 335     


Ile Trp Glu Gly Ser Ser Lys Cys Asn Ile Asn Asn Phe Ile Phe His 
            340                 345                 350         


Lys Val Leu Gly Lys Gly Ser Phe Gly Lys Val Leu Leu Gly Glu Leu 
        355                 360                 365             


Lys Gly Arg Gly Glu Tyr Phe Ala Ile Lys Ala Leu Lys Lys Asp Val 
    370                 375                 380                 


Val Leu Ile Asp Asp Asp Val Glu Cys Thr Met Val Glu Lys Arg Val 
385                 390                 395                 400 


Leu Thr Leu Ala Ala Glu Asn Pro Phe Leu Thr His Leu Ile Cys Thr 
                405                 410                 415     


Phe Gln Thr Lys Asp His Leu Phe Phe Val Met Glu Phe Leu Asn Gly 
            420                 425                 430         


Gly Asp Leu Met Tyr His Ile Gln Asp Lys Gly Arg Phe Glu Leu Tyr 
        435                 440                 445             


Arg Ala Thr Phe Tyr Ala Ala Glu Ile Met Cys Gly Leu Gln Phe Leu 
    450                 455                 460                 


His Ser Lys Gly Ile Ile Tyr Arg Asp Leu Lys Leu Asp Asn Val Leu 
465                 470                 475                 480 


Leu Asp Arg Asp Gly His Ile Lys Ile Ala Asp Phe Gly Met Cys Lys 
                485                 490                 495     


Glu Asn Ile Phe Gly Glu Ser Arg Ala Ser Thr Phe Cys Gly Thr Pro 
            500                 505                 510         


Asp Tyr Ile Ala Pro Glu Ile Leu Gln Gly Leu Lys Tyr Thr Phe Ser 
        515                 520                 525             


Val Asp Trp Trp Ser Phe Gly Val Leu Leu Tyr Glu Met Leu Ile Gly 
    530                 535                 540                 


Gln Ser Pro Phe His Gly Asp Asp Glu Asp Glu Leu Phe Glu Ser Ile 
545                 550                 555                 560 


Arg Val Asp Thr Pro His Tyr Pro Arg Trp Ile Thr Lys Glu Ser Lys 
                565                 570                 575     


Asp Ile Leu Glu Lys Leu Phe Glu Arg Glu Pro Thr Lys Arg Leu Gly 
            580                 585                 590         


Val Thr Gly Asn Ile Lys Ile His Pro Phe Phe Lys Thr Ile Asn Trp 
        595                 600                 605             


Thr Leu Leu Glu Lys Arg Arg Leu Glu Pro Pro Phe Arg Pro Lys Val 
    610                 615                 620                 


Lys Ser Pro Arg Asp Tyr Ser Asn Phe Asp Gln Glu Phe Leu Asn Glu 
625                 630                 635                 640 


Lys Ala Arg Leu Ser Tyr Ser Asp Lys Asn Leu Ile Asp Ser Met Asp 
                645                 650                 655     


Gln Ser Ala Phe Ala Gly Phe Ser Phe Val Asn Pro Lys Phe Glu His 
            660                 665                 670         


Leu Leu Glu 
        675 


<210>  429
<211>  309
<212>  PRT
<213>  Homo sapiens

<400>  429

Met Ser Pro Ser Pro Ser Asn Ser Tyr Asp Thr Ser Pro Gln Pro Cys 
1               5                   10                  15      


Thr Thr Asn Gln Asn Gly Arg Glu Asn Asn Glu Arg Leu Ser Thr Ser 
            20                  25                  30          


Asn Gly Lys Met Ser Pro Thr Arg Tyr His Ala Asn Ser Met Gly Gln 
        35                  40                  45              


Arg Ser Tyr Ser Phe Glu Ala Ser Glu Glu Asp Leu Asp Val Asp Asp 
    50                  55                  60                  


Lys Val Glu Glu Leu Met Arg Arg Asp Ser Ser Val Ile Lys Glu Glu 
65                  70                  75                  80  


Ile Lys Ala Phe Leu Ala Asn Arg Arg Ile Ser Gln Ala Val Val Ala 
                85                  90                  95      


Gln Val Thr Gly Ile Ser Gln Ser Arg Ile Ser His Trp Leu Leu Gln 
            100                 105                 110         


Gln Gly Ser Asp Leu Ser Glu Gln Lys Lys Arg Ala Phe Tyr Arg Trp 
        115                 120                 125             


Tyr Gln Leu Glu Lys Thr Asn Pro Gly Ala Thr Leu Ser Met Arg Pro 
    130                 135                 140                 


Ala Pro Ile Pro Ile Glu Asp Pro Glu Trp Arg Gln Thr Pro Pro Pro 
145                 150                 155                 160 


Val Ser Ala Thr Ser Gly Thr Phe Arg Leu Arg Arg Gly Ser Arg Phe 
                165                 170                 175     


Thr Trp Arg Lys Glu Cys Leu Ala Val Met Glu Ser Tyr Phe Asn Glu 
            180                 185                 190         


Asn Gln Tyr Pro Asp Glu Ala Lys Arg Glu Glu Ile Ala Asn Ala Cys 
        195                 200                 205             


Asn Ala Val Ile Gln Lys Pro Gly Lys Lys Leu Ser Asp Leu Glu Arg 
    210                 215                 220                 


Val Thr Ser Leu Lys Val Tyr Asn Trp Phe Ala Asn Arg Arg Lys Glu 
225                 230                 235                 240 


Ile Lys Arg Arg Ala Asn Ile Ala Ala Ile Leu Glu Ser His Gly Ile 
                245                 250                 255     


Asp Val Gln Ser Pro Gly Gly His Ser Asn Ser Asp Asp Val Asp Gly 
            260                 265                 270         


Asn Asp Tyr Ser Glu Gln Asp Thr Trp Gln Val Arg Asn Gly Glu Glu 
        275                 280                 285             


Glu Glu Gly Arg Ser Ser Glu Gly Gly Arg Glu Ala Glu Lys Val Glu 
    290                 295                 300                 


Glu Glu Arg Arg Ile 
305                 


<210>  430
<211>  367
<212>  PRT
<213>  Homo sapiens

<400>  430

Met Asn Ser Ser Pro Ala Gly Thr Pro Ser Pro Gln Pro Ser Arg Ala 
1               5                   10                  15      


Asn Gly Asn Ile Asn Leu Gly Pro Ser Ala Asn Pro Asn Ala Gln Pro 
            20                  25                  30          


Thr Asp Phe Asp Phe Leu Lys Val Ile Gly Lys Gly Asn Tyr Gly Lys 
        35                  40                  45              


Val Leu Leu Ala Lys Arg Lys Ser Asp Gly Ala Phe Tyr Ala Val Lys 
    50                  55                  60                  


Val Leu Gln Lys Lys Ser Ile Leu Lys Lys Lys Glu Gln Ser His Ile 
65                  70                  75                  80  


Met Ala Glu Arg Ser Val Leu Leu Lys Asn Val Arg His Pro Phe Leu 
                85                  90                  95      


Val Gly Leu Arg Tyr Ser Phe Gln Thr Pro Glu Lys Leu Tyr Phe Val 
            100                 105                 110         


Leu Asp Tyr Val Asn Gly Gly Glu Leu Phe Phe His Leu Gln Arg Glu 
        115                 120                 125             


Arg Arg Phe Leu Glu Pro Arg Ala Arg Phe Tyr Ala Ala Glu Val Ala 
    130                 135                 140                 


Ser Ala Ile Gly Tyr Leu His Ser Leu Asn Ile Ile Tyr Arg Asp Leu 
145                 150                 155                 160 


Lys Pro Glu Asn Ile Leu Leu Asp Cys Gln Gly His Val Val Leu Thr 
                165                 170                 175     


Asp Phe Gly Leu Cys Lys Glu Gly Val Glu Pro Glu Asp Thr Thr Ser 
            180                 185                 190         


Thr Phe Cys Gly Thr Pro Glu Tyr Leu Ala Pro Glu Val Leu Arg Lys 
        195                 200                 205             


Glu Pro Tyr Asp Arg Ala Val Asp Trp Trp Cys Leu Gly Ala Val Leu 
    210                 215                 220                 


Tyr Glu Met Leu His Gly Leu Pro Pro Phe Tyr Ser Gln Asp Val Ser 
225                 230                 235                 240 


Gln Met Tyr Glu Asn Ile Leu His Gln Pro Leu Gln Ile Pro Gly Gly 
                245                 250                 255     


Arg Thr Val Ala Ala Cys Asp Leu Leu Gln Ser Leu Leu His Lys Asp 
            260                 265                 270         


Gln Arg Gln Arg Leu Gly Ser Lys Ala Asp Phe Leu Glu Ile Lys Asn 
        275                 280                 285             


His Val Phe Phe Ser Pro Ile Asn Trp Asp Asp Leu Tyr His Lys Arg 
    290                 295                 300                 


Leu Thr Pro Pro Phe Asn Pro Asn Val Thr Gly Pro Ala Asp Leu Lys 
305                 310                 315                 320 


His Phe Asp Pro Glu Phe Thr Gln Glu Ala Val Ser Lys Ser Ile Gly 
                325                 330                 335     


Cys Thr Pro Asp Thr Val Ala Ser Ser Ser Gly Ala Ser Ser Ala Phe 
            340                 345                 350         


Leu Gly Phe Ser Tyr Ala Pro Glu Asp Asp Asp Ile Leu Asp Cys 
        355                 360                 365         


<210>  431
<211>  311
<212>  PRT
<213>  Homo sapiens

<400>  431

Met Gly Val Pro Thr Ala Leu Glu Ala Gly Ser Trp Arg Trp Gly Ser 
1               5                   10                  15      


Leu Leu Phe Ala Leu Phe Leu Ala Ala Ser Leu Gly Pro Val Ala Ala 
            20                  25                  30          


Phe Lys Val Ala Thr Pro Tyr Ser Leu Tyr Val Cys Pro Glu Gly Gln 
        35                  40                  45              


Asn Val Thr Leu Thr Cys Arg Leu Leu Gly Pro Val Asp Lys Gly His 
    50                  55                  60                  


Asp Val Thr Phe Tyr Lys Thr Trp Tyr Arg Ser Ser Arg Gly Glu Val 
65                  70                  75                  80  


Gln Thr Cys Ser Glu Arg Arg Pro Ile Arg Asn Leu Thr Phe Gln Asp 
                85                  90                  95      


Leu His Leu His His Gly Gly His Gln Ala Ala Asn Thr Ser His Asp 
            100                 105                 110         


Leu Ala Gln Arg His Gly Leu Glu Ser Ala Ser Asp His His Gly Asn 
        115                 120                 125             


Phe Ser Ile Thr Met Arg Asn Leu Thr Leu Leu Asp Ser Gly Leu Tyr 
    130                 135                 140                 


Cys Cys Leu Val Val Glu Ile Arg His His His Ser Glu His Arg Val 
145                 150                 155                 160 


His Gly Ala Met Glu Leu Gln Val Gln Thr Gly Lys Asp Ala Pro Ser 
                165                 170                 175     


Asn Cys Val Val Tyr Pro Ser Ser Ser Gln Glu Ser Glu Asn Ile Thr 
            180                 185                 190         


Ala Ala Ala Leu Ala Thr Gly Ala Cys Ile Val Gly Ile Leu Cys Leu 
        195                 200                 205             


Pro Leu Ile Leu Leu Leu Val Tyr Lys Gln Arg Gln Ala Ala Ser Asn 
    210                 215                 220                 


Arg Arg Ala Gln Glu Leu Val Arg Met Asp Ser Asn Ile Gln Gly Ile 
225                 230                 235                 240 


Glu Asn Pro Gly Phe Glu Ala Ser Pro Pro Ala Gln Gly Ile Pro Glu 
                245                 250                 255     


Ala Lys Val Arg His Pro Leu Ser Tyr Val Ala Gln Arg Gln Pro Ser 
            260                 265                 270         


Glu Ser Gly Arg His Leu Leu Ser Glu Pro Ser Thr Pro Leu Ser Pro 
        275                 280                 285             


Pro Gly Pro Gly Asp Val Phe Phe Pro Ser Leu Asp Pro Val Pro Asp 
    290                 295                 300                 


Ser Pro Asn Phe Glu Val Ile 
305                 310     


<210>  432
<211>  474
<212>  PRT
<213>  Homo sapiens

<400>  432

Met Ser Tyr Tyr His His His His His His Asp Tyr Asp Ile Pro Thr 
1               5                   10                  15      


Thr Glu Asn Leu Tyr Phe Gln Gly Ala Met Leu Val Pro Arg Gly Ser 
            20                  25                  30          


Pro Trp Ile Pro Phe Thr Met Lys Lys Arg Lys Gln Ile Lys Asp Leu 
        35                  40                  45              


Gly Ser Glu Leu Val Arg Tyr Asp Ala Arg Val His Thr Pro His Leu 
    50                  55                  60                  


Asp Arg Leu Val Ser Ala Arg Ser Val Ser Pro Thr Thr Glu Met Val 
65                  70                  75                  80  


Ser Asn Glu Ser Val Asp Tyr Arg Ala Thr Phe Pro Glu Asp Gln Phe 
                85                  90                  95      


Pro Asn Ser Ser Gln Asn Gly Ser Cys Arg Gln Val Gln Tyr Pro Leu 
            100                 105                 110         


Thr Asp Met Ser Pro Ile Leu Thr Ser Gly Asp Ser Asp Ile Ser Ser 
        115                 120                 125             


Pro Leu Leu Gln Asn Thr Val His Ile Asp Leu Ser Ala Leu Asn Pro 
    130                 135                 140                 


Glu Leu Val Gln Ala Val Gln His Val Val Ile Gly Pro Ser Ser Leu 
145                 150                 155                 160 


Ile Val His Phe Asn Glu Val Ile Gly Arg Gly His Phe Gly Cys Val 
                165                 170                 175     


Tyr His Gly Thr Leu Leu Asp Asn Asp Gly Lys Lys Ile His Cys Ala 
            180                 185                 190         


Val Lys Ser Leu Asn Arg Ile Thr Asp Ile Gly Glu Val Ser Gln Phe 
        195                 200                 205             


Leu Thr Glu Gly Ile Ile Met Lys Asp Phe Ser His Pro Asn Val Leu 
    210                 215                 220                 


Ser Leu Leu Gly Ile Cys Leu Arg Ser Glu Gly Ser Pro Leu Val Val 
225                 230                 235                 240 


Leu Pro Tyr Met Lys His Gly Asp Leu Arg Asn Phe Ile Arg Asn Glu 
                245                 250                 255     


Thr His Asn Pro Thr Val Lys Asp Leu Ile Gly Phe Gly Leu Gln Val 
            260                 265                 270         


Ala Lys Gly Met Lys Tyr Leu Ala Ser Lys Lys Phe Val His Arg Asp 
        275                 280                 285             


Leu Ala Ala Arg Asn Cys Met Leu Asp Glu Lys Phe Thr Val Lys Val 
    290                 295                 300                 


Ala Asp Phe Gly Leu Ala Arg Asp Met Tyr Asp Lys Glu Tyr Tyr Ser 
305                 310                 315                 320 


Val His Asn Lys Thr Gly Ala Lys Leu Pro Val Lys Trp Met Ala Leu 
                325                 330                 335     


Glu Ser Leu Gln Thr Gln Lys Phe Thr Thr Lys Ser Asp Val Trp Ser 
            340                 345                 350         


Phe Gly Val Leu Leu Trp Glu Leu Met Thr Arg Gly Ala Pro Pro Tyr 
        355                 360                 365             


Pro Asp Val Asn Thr Phe Asp Ile Thr Val Tyr Leu Leu Gln Gly Arg 
    370                 375                 380                 


Arg Leu Leu Gln Pro Glu Tyr Cys Pro Asp Pro Leu Tyr Glu Val Met 
385                 390                 395                 400 


Leu Lys Cys Trp His Pro Lys Ala Glu Met Arg Pro Ser Phe Ser Glu 
                405                 410                 415     


Leu Val Ser Arg Ile Ser Ala Ile Phe Ser Thr Phe Ile Gly Glu His 
            420                 425                 430         


Tyr Val His Val Asn Ala Thr Tyr Val Asn Val Lys Cys Val Ala Pro 
        435                 440                 445             


Tyr Pro Ser Leu Leu Ser Ser Glu Asp Asn Ala Asp Asp Glu Val Asp 
    450                 455                 460                 


Thr Arg Pro Ala Ser Phe Trp Glu Thr Ser 
465                 470                 


<210>  433
<211>  175
<212>  PRT
<213>  Homo sapiens

<400>  433

Met Thr Ala Ile Ser Val Ile Asn Arg Ile Thr Pro Val Leu Gln Asp 
1               5                   10                  15      


Thr Ala Phe Ile Thr Ser Gly Cys Asp His Gln Gln Thr Glu Lys Asn 
            20                  25                  30          


Lys Val Ile Lys Tyr Pro Arg Ser Arg Leu Asp Ala Lys Ile Lys Gln 
        35                  40                  45              


Ser Trp Asn Lys Glu Ser His Phe Gln Gly Asn Tyr Val Lys Ser Val 
    50                  55                  60                  


Val Ala Phe Gly Gln Pro Arg Gly Glu Leu Ser Gln Pro Arg Leu Leu 
65                  70                  75                  80  


Thr Leu Pro His Thr Leu Ser Val Tyr Glu Gly Ser Pro Arg Asn Gln 
                85                  90                  95      


Leu Pro Pro Gly Arg Phe Val Pro Phe Lys Asn Gln Pro Cys Gly Gly 
            100                 105                 110         


Ile Leu Gly Leu Gly Gln Met Thr Val Ser Pro Lys Tyr Leu His Ala 
        115                 120                 125             


Gln Gly Thr Ala Pro Phe Ile Pro Ala Ala Gly Ser Gly Pro Pro Asn 
    130                 135                 140                 


Ser Pro Thr Asn Leu Pro Ser Lys Val Val Asn Asn Lys Asp Phe Leu 
145                 150                 155                 160 


Cys Gly Lys Ser Cys Ser Lys Leu Cys Thr Asp Glu Ser Thr Asn 
                165                 170                 175 


<210>  434
<211>  683
<212>  PRT
<213>  Homo sapiens

<400>  434

Met Glu Arg Ala Ala Pro Ser Arg Arg Val Pro Leu Gln Leu Leu Leu 
1               5                   10                  15      


Leu Gly Gly Leu Ala Leu Leu Ala Ala Gly Val Asp Ala Asp Val Leu 
            20                  25                  30          


Leu Glu Ala Cys Cys Ala Asp Gly His Arg Met Ala Thr His Gln Lys 
        35                  40                  45              


Asp Cys Ser Leu Pro Tyr Ala Thr Glu Ser Lys Glu Cys Arg Met Val 
    50                  55                  60                  


Gln Glu Gln Cys Cys His Ser Gln Leu Glu Glu Leu His Cys Ala Thr 
65                  70                  75                  80  


Gly Ile Ser Leu Ala Asn Glu Gln Asp Arg Cys Ala Thr Pro His Gly 
                85                  90                  95      


Asp Asn Ala Ser Leu Glu Ala Thr Phe Val Lys Arg Cys Cys His Cys 
            100                 105                 110         


Cys Leu Leu Gly Arg Ala Ala Gln Ala Gln Gly Gln Ser Cys Glu Tyr 
        115                 120                 125             


Ser Leu Met Val Gly Tyr Gln Cys Gly Gln Val Phe Arg Ala Cys Cys 
    130                 135                 140                 


Val Lys Ser Gln Glu Thr Gly Asp Leu Asp Val Gly Gly Leu Gln Glu 
145                 150                 155                 160 


Thr Asp Lys Ile Ile Glu Val Glu Glu Glu Gln Glu Asp Pro Tyr Leu 
                165                 170                 175     


Asn Asp Arg Cys Arg Gly Gly Gly Pro Cys Lys Gln Gln Cys Arg Asp 
            180                 185                 190         


Thr Gly Asp Glu Val Val Cys Ser Cys Phe Val Gly Tyr Gln Leu Leu 
        195                 200                 205             


Ser Asp Gly Val Ser Cys Glu Asp Val Asn Glu Cys Ile Thr Gly Ser 
    210                 215                 220                 


His Ser Cys Arg Leu Gly Glu Ser Cys Ile Asn Thr Val Gly Ser Phe 
225                 230                 235                 240 


Arg Cys Gln Arg Asp Ser Ser Cys Gly Thr Gly Tyr Glu Leu Thr Glu 
                245                 250                 255     


Asp Asn Ser Cys Lys Asp Ile Asp Glu Cys Glu Ser Gly Ile His Asn 
            260                 265                 270         


Cys Leu Pro Asp Phe Ile Cys Gln Asn Thr Leu Gly Ser Phe Arg Cys 
        275                 280                 285             


Arg Pro Lys Leu Gln Cys Lys Ser Gly Phe Ile Gln Asp Ala Leu Gly 
    290                 295                 300                 


Asn Cys Ile Asp Ile Asn Glu Cys Leu Ser Ile Ser Ala Pro Cys Pro 
305                 310                 315                 320 


Ile Gly His Thr Cys Ile Asn Thr Glu Gly Ser Tyr Thr Cys Gln Lys 
                325                 330                 335     


Asn Val Pro Asn Cys Gly Arg Gly Tyr His Leu Asn Glu Glu Gly Thr 
            340                 345                 350         


Arg Cys Val Asp Val Asp Glu Cys Ala Pro Pro Ala Glu Pro Cys Gly 
        355                 360                 365             


Lys Gly His Arg Cys Val Asn Ser Pro Gly Ser Phe Arg Cys Glu Cys 
    370                 375                 380                 


Lys Thr Gly Tyr Tyr Phe Asp Gly Ile Ser Arg Met Cys Val Asp Val 
385                 390                 395                 400 


Asn Glu Cys Gln Arg Tyr Pro Gly Arg Leu Cys Gly His Lys Cys Glu 
                405                 410                 415     


Asn Thr Leu Gly Ser Tyr Leu Cys Ser Cys Ser Val Gly Phe Arg Leu 
            420                 425                 430         


Ser Val Asp Gly Arg Ser Cys Glu Asp Ile Asn Glu Cys Ser Ser Ser 
        435                 440                 445             


Pro Cys Ser Gln Glu Cys Ala Asn Val Tyr Gly Ser Tyr Gln Cys Tyr 
    450                 455                 460                 


Cys Arg Arg Gly Tyr Gln Leu Ser Asp Val Asp Gly Val Thr Cys Glu 
465                 470                 475                 480 


Asp Ile Asp Glu Cys Ala Leu Pro Thr Gly Gly His Ile Cys Ser Tyr 
                485                 490                 495     


Arg Cys Ile Asn Ile Pro Gly Ser Phe Gln Cys Ser Cys Pro Ser Ser 
            500                 505                 510         


Gly Tyr Arg Leu Ala Pro Asn Gly Ser Asn Cys Gln Asp Ile Asp Glu 
        515                 520                 525             


Cys Val Thr Gly Ile His Asn Cys Ser Ile Asn Glu Thr Cys Phe Asn 
    530                 535                 540                 


Ile Gln Gly Gly Phe Arg Cys Leu Ala Phe Glu Cys Pro Glu Asn Tyr 
545                 550                 555                 560 


Arg Arg Ser Ala Ala Thr Arg Cys Glu Arg Leu Pro Cys His Glu Asn 
                565                 570                 575     


Arg Glu Cys Ser Lys Leu Pro Leu Arg Ile Thr Tyr Tyr His Leu Ser 
            580                 585                 590         


Phe Pro Thr Asn Ile Gln Ala Pro Ala Val Val Phe Arg Met Gly Pro 
        595                 600                 605             


Ser Ser Ala Val Pro Gly Asp Ser Met Gln Leu Ala Ile Thr Gly Gly 
    610                 615                 620                 


Asn Glu Glu Gly Phe Phe Thr Thr Arg Lys Val Ser Pro His Ser Gly 
625                 630                 635                 640 


Val Val Ala Leu Thr Lys Pro Val Pro Glu Pro Arg Asp Leu Leu Leu 
                645                 650                 655     


Thr Val Lys Met Asp Leu Ser Arg His Gly Thr Val Ser Ser Phe Val 
            660                 665                 670         


Ala Lys Leu Phe Ile Phe Val Ser Ala Glu Leu 
        675                 680             


<210>  435
<211>  271
<212>  PRT
<213>  Homo sapiens

<400>  435

Met Glu Ala Leu Pro Leu Leu Ala Ala Thr Thr Pro Asp His Gly Arg 
1               5                   10                  15      


His Arg Arg Leu Leu Leu Leu Pro Leu Leu Leu Phe Leu Leu Pro Ala 
            20                  25                  30          


Gly Ala Val Gln Gly Trp Glu Thr Glu Glu Arg Pro Arg Thr Arg Glu 
        35                  40                  45              


Glu Glu Cys His Phe Tyr Ala Gly Gly Gln Val Tyr Pro Gly Glu Ala 
    50                  55                  60                  


Ser Arg Val Ser Val Ala Asp His Ser Leu His Leu Ser Lys Ala Lys 
65                  70                  75                  80  


Ile Ser Lys Pro Ala Pro Tyr Trp Glu Gly Thr Ala Val Ile Asp Gly 
                85                  90                  95      


Glu Phe Lys Glu Leu Lys Leu Thr Asp Tyr Arg Gly Lys Tyr Leu Val 
            100                 105                 110         


Phe Phe Phe Tyr Pro Leu Asp Phe Thr Phe Val Cys Pro Thr Glu Ile 
        115                 120                 125             


Ile Ala Phe Gly Asp Arg Leu Glu Glu Phe Arg Ser Ile Asn Thr Glu 
    130                 135                 140                 


Val Val Ala Cys Ser Val Asp Ser Gln Phe Thr His Leu Ala Trp Ile 
145                 150                 155                 160 


Asn Thr Pro Arg Arg Gln Gly Gly Leu Gly Pro Ile Arg Ile Pro Leu 
                165                 170                 175     


Leu Ser Asp Leu Thr His Gln Ile Ser Lys Asp Tyr Gly Val Tyr Leu 
            180                 185                 190         


Glu Asp Ser Gly His Thr Leu Arg Gly Leu Phe Ile Ile Asp Asp Lys 
        195                 200                 205             


Gly Ile Leu Arg Gln Ile Thr Leu Asn Asp Leu Pro Val Gly Arg Ser 
    210                 215                 220                 


Val Asp Glu Thr Leu Arg Leu Val Gln Ala Phe Gln Tyr Thr Asp Lys 
225                 230                 235                 240 


His Gly Glu Val Cys Pro Ala Gly Trp Lys Pro Gly Ser Glu Thr Ile 
                245                 250                 255     


Ile Pro Asp Pro Ala Gly Lys Leu Lys Tyr Phe Asp Lys Leu Asn 
            260                 265                 270     


<210>  436
<211>  321
<212>  PRT
<213>  Homo sapiens

<400>  436

Met Ser Leu Gln Lys Leu Met Glu Pro Glu Ala Gly Thr Asn Arg Thr 
1               5                   10                  15      


Ala Val Ala Glu Phe Ile Leu Leu Gly Leu Val Gln Thr Glu Glu Met 
            20                  25                  30          


Gln Pro Val Val Phe Val Leu Leu Leu Phe Ala Tyr Leu Val Thr Thr 
        35                  40                  45              


Gly Gly Asn Leu Ser Ile Leu Ala Ala Val Leu Val Glu Pro Lys Leu 
    50                  55                  60                  


His Ala Pro Met Tyr Phe Phe Leu Gly Asn Leu Ser Val Leu Asp Val 
65                  70                  75                  80  


Gly Cys Ile Thr Val Thr Val Pro Ala Met Leu Gly Arg Leu Leu Ser 
                85                  90                  95      


His Lys Ser Thr Ile Ser Tyr Asp Ala Cys Leu Ser Gln Leu Phe Phe 
            100                 105                 110         


Phe His Leu Leu Ala Gly Met Asp Cys Phe Leu Leu Thr Ala Met Ala 
        115                 120                 125             


Tyr Asp Arg Leu Leu Ala Ile Cys Gln Pro Leu Thr Tyr Ser Thr Arg 
    130                 135                 140                 


Met Ser Gln Thr Val Gln Arg Met Leu Val Ala Ala Ser Trp Ala Cys 
145                 150                 155                 160 


Ala Phe Thr Asn Ala Leu Thr His Thr Val Ala Met Ser Thr Leu Asn 
                165                 170                 175     


Phe Cys Gly Pro Asn Glu Val Asn His Phe Tyr Cys Asp Leu Pro Gln 
            180                 185                 190         


Leu Phe Gln Leu Ser Cys Ser Ser Thr Gln Leu Asn Glu Leu Leu Leu 
        195                 200                 205             


Phe Val Ala Ala Ala Phe Met Ala Val Ala Pro Leu Val Phe Ile Ser 
    210                 215                 220                 


Val Ser Tyr Ala His Val Val Ala Ala Val Leu Gln Ile Arg Ser Ala 
225                 230                 235                 240 


Glu Gly Arg Lys Lys Ala Phe Ser Thr Cys Gly Ser His Leu Thr Val 
                245                 250                 255     


Val Gly Ile Phe Tyr Gly Thr Gly Val Phe Ser Tyr Met Arg Leu Gly 
            260                 265                 270         


Ser Val Glu Ser Ser Asp Lys Asp Lys Gly Val Gly Val Phe Met Thr 
        275                 280                 285             


Val Ile Asn Pro Met Leu Asn Pro Leu Ile Tyr Ser Leu Arg Asn Thr 
    290                 295                 300                 


Asp Val Gln Gly Ala Leu Cys Gln Leu Leu Val Gly Glu Arg Ser Leu 
305                 310                 315                 320 


Thr 
    


<210>  437
<211>  269
<212>  PRT
<213>  Homo sapiens

<400>  437

Met Ser Ser Tyr Phe Val Asn Ser Phe Ser Gly Arg Tyr Pro Asn Gly 
1               5                   10                  15      


Pro Asp Tyr Gln Leu Leu Asn Tyr Gly Ser Gly Ser Ser Leu Ser Gly 
            20                  25                  30          


Ser Tyr Arg Asp Pro Ala Ala Met His Thr Gly Ser Tyr Gly Tyr Asn 
        35                  40                  45              


Tyr Asn Gly Met Asp Leu Ser Val Asn Arg Ser Ser Ala Ser Ser Ser 
    50                  55                  60                  


His Phe Gly Ala Val Gly Glu Ser Ser Arg Ala Phe Pro Ala Pro Ala 
65                  70                  75                  80  


Gln Glu Pro Arg Phe Arg Gln Ala Ala Ser Ser Cys Ser Leu Ser Ser 
                85                  90                  95      


Pro Glu Ser Leu Pro Cys Thr Asn Gly Asp Ser His Gly Ala Lys Pro 
            100                 105                 110         


Ser Ala Ser Ser Pro Ser Asp Gln Ala Thr Ser Ala Ser Ser Ser Ala 
        115                 120                 125             


Asn Phe Thr Glu Ile Asp Glu Ala Ser Ala Ser Ser Glu Pro Glu Glu 
    130                 135                 140                 


Ala Ala Ser Gln Leu Ser Ser Pro Ser Leu Ala Arg Ala Gln Pro Glu 
145                 150                 155                 160 


Pro Met Ala Thr Ser Thr Ala Ala Pro Glu Gly Gln Thr Pro Gln Ile 
                165                 170                 175     


Phe Pro Trp Met Arg Lys Leu His Ile Ser His Asp Met Thr Gly Pro 
            180                 185                 190         


Asp Gly Lys Arg Ala Arg Thr Ala Tyr Thr Arg Tyr Gln Thr Leu Glu 
        195                 200                 205             


Leu Glu Lys Glu Phe His Phe Asn Arg Tyr Leu Thr Arg Arg Arg Arg 
    210                 215                 220                 


Ile Glu Ile Ala His Ala Leu Cys Leu Ser Glu Arg Gln Ile Lys Ile 
225                 230                 235                 240 


Trp Phe Gln Asn Arg Arg Met Lys Trp Lys Lys Asp Asn Lys Leu Lys 
                245                 250                 255     


Ser Met Ser Leu Ala Thr Ala Gly Ser Ala Phe Gln Pro 
            260                 265                 


<210>  438
<211>  188
<212>  PRT
<213>  Homo sapiens

<400>  438

Met Thr Glu Tyr Lys Leu Val Val Val Gly Ala Gly Gly Val Gly Lys 
1               5                   10                  15      


Ser Ala Leu Thr Ile Gln Leu Ile Gln Asn His Phe Val Asp Glu Tyr 
            20                  25                  30          


Asp Pro Thr Ile Glu Asp Ser Tyr Arg Lys Gln Val Val Ile Asp Gly 
        35                  40                  45              


Glu Thr Cys Leu Leu Asp Ile Leu Asp Thr Ala Gly His Glu Glu Tyr 
    50                  55                  60                  


Ser Ala Met Arg Asp Gln Tyr Met Arg Thr Gly Glu Gly Phe Leu Cys 
65                  70                  75                  80  


Val Phe Ala Ile Asn Asn Thr Lys Ser Phe Glu Asp Ile His His Tyr 
                85                  90                  95      


Arg Glu Gln Ile Lys Arg Val Lys Asp Ser Glu Asp Val Pro Met Val 
            100                 105                 110         


Leu Val Gly Asn Lys Cys Asp Leu Pro Ser Arg Thr Val Asp Thr Lys 
        115                 120                 125             


Gln Ala Gln Asp Leu Ala Arg Ser Tyr Gly Ile Pro Phe Ile Glu Thr 
    130                 135                 140                 


Ser Ala Lys Thr Arg Gln Gly Val Asp Asp Ala Phe Tyr Thr Leu Val 
145                 150                 155                 160 


Arg Glu Ile Arg Lys His Lys Glu Lys Met Ser Lys Asp Gly Lys Lys 
                165                 170                 175     


Lys Lys Lys Lys Ser Lys Thr Lys Cys Val Ile Met 
            180                 185             


<210>  439
<211>  420
<212>  PRT
<213>  Homo sapiens

<400>  439

Met Leu Ser Ser Phe Pro Val Val Leu Leu Glu Thr Met Ser His Tyr 
1               5                   10                  15      


Thr Asp Glu Pro Arg Phe Thr Ile Glu Gln Ile Asp Leu Leu Gln Arg 
            20                  25                  30          


Leu Arg Arg Thr Gly Met Thr Lys His Glu Ile Leu His Ala Leu Glu 
        35                  40                  45              


Thr Leu Asp Arg Leu Asp Gln Glu His Ser Asp Lys Phe Gly Arg Arg 
    50                  55                  60                  


Ser Ser Tyr Gly Gly Ser Ser Tyr Gly Asn Ser Thr Asn Asn Val Pro 
65                  70                  75                  80  


Ala Ser Ser Ser Thr Ala Thr Ala Ser Thr Gln Thr Gln His Ser Gly 
                85                  90                  95      


Met Ser Pro Ser Pro Ser Asn Ser Tyr Asp Thr Ser Pro Gln Pro Cys 
            100                 105                 110         


Thr Thr Asn Gln Asn Gly Arg Glu Asn Asn Glu Arg Leu Ser Thr Ser 
        115                 120                 125             


Asn Gly Lys Met Ser Pro Thr Arg Tyr His Ala Asn Ser Met Gly Gln 
    130                 135                 140                 


Arg Ser Tyr Ser Phe Glu Ala Ser Glu Glu Asp Leu Asp Val Asp Asp 
145                 150                 155                 160 


Lys Val Glu Glu Leu Met Arg Arg Asp Ser Ser Val Ile Lys Glu Glu 
                165                 170                 175     


Ile Lys Ala Phe Leu Ala Asn Arg Arg Ile Ser Gln Ala Val Val Ala 
            180                 185                 190         


Gln Val Thr Gly Ile Ser Gln Ser Arg Ile Ser His Trp Leu Leu Gln 
        195                 200                 205             


Gln Gly Ser Asp Leu Ser Glu Gln Lys Lys Arg Ala Phe Tyr Arg Trp 
    210                 215                 220                 


Tyr Gln Leu Glu Lys Thr Asn Pro Gly Ala Thr Leu Ser Met Arg Pro 
225                 230                 235                 240 


Ala Pro Ile Pro Ile Glu Asp Pro Glu Trp Arg Gln Thr Pro Pro Pro 
                245                 250                 255     


Val Ser Ala Thr Ser Gly Thr Phe Arg Leu Arg Arg Gly Ser Arg Phe 
            260                 265                 270         


Thr Trp Arg Lys Glu Cys Leu Ala Val Met Glu Ser Tyr Phe Asn Glu 
        275                 280                 285             


Asn Gln Tyr Pro Asp Glu Ala Lys Arg Glu Glu Ile Ala Asn Ala Cys 
    290                 295                 300                 


Asn Ala Val Ile Gln Lys Pro Gly Lys Lys Leu Ser Asp Leu Glu Arg 
305                 310                 315                 320 


Val Thr Ser Leu Lys Val Tyr Asn Trp Phe Ala Asn Arg Arg Lys Glu 
                325                 330                 335     


Ile Lys Arg Arg Ala Asn Ile Glu Ala Ala Ile Leu Glu Ser His Gly 
            340                 345                 350         


Ile Asp Val Gln Ser Pro Gly Gly His Ser Asn Ser Asp Asp Val Asp 
        355                 360                 365             


Gly Asn Asp Tyr Ser Glu Gln Asp Asp Ser Thr Ser His Ser Asp His 
    370                 375                 380                 


Gln Asp Pro Ile Ser Leu Ala Val Glu Met Ala Ala Val Asn His Thr 
385                 390                 395                 400 


Ile Leu Ala Leu Ala Arg Gln Gly Ala Asn Glu Ile Lys Thr Glu Ala 
                405                 410                 415     


Leu Asp Asp Asp 
            420 


<210>  440
<211>  161
<212>  PRT
<213>  Homo sapiens

<400>  440

Met Ala Gly Arg Lys Leu Ala Leu Lys Thr Ile Asp Trp Val Ala Phe 
1               5                   10                  15      


Ala Glu Ile Ile Pro Gln Asn Gln Lys Ala Ile Ala Ser Ser Leu Lys 
            20                  25                  30          


Ser Trp Asn Glu Thr Leu Thr Ser Arg Leu Ala Ala Leu Pro Glu Asn 
        35                  40                  45              


Pro Pro Ala Ile Asp Trp Ala Tyr Tyr Lys Ala Asn Val Ala Lys Ala 
    50                  55                  60                  


Gly Leu Val Asp Asp Phe Glu Lys Lys Phe Asn Ala Leu Lys Val Pro 
65                  70                  75                  80  


Val Pro Glu Asp Lys Tyr Thr Ala Gln Val Asp Ala Glu Glu Lys Glu 
                85                  90                  95      


Asp Val Lys Ser Cys Ala Glu Trp Val Ser Leu Ser Lys Ala Arg Ile 
            100                 105                 110         


Val Glu Tyr Glu Lys Glu Met Glu Lys Met Lys Asn Leu Ile Pro Phe 
        115                 120                 125             


Asp Gln Met Thr Ile Glu Asp Leu Asn Glu Ala Phe Pro Glu Thr Lys 
    130                 135                 140                 


Leu Asp Lys Lys Lys Tyr Pro Tyr Trp Pro His Gln Pro Ile Glu Asn 
145                 150                 155                 160 


Leu 
    


<210>  441
<211>  563
<212>  PRT
<213>  Homo sapiens

<400>  441

Met Glu Gly Pro Leu Thr Pro Pro Pro Leu Gln Gly Gly Gly Ala Ala 
1               5                   10                  15      


Ala Val Pro Glu Pro Gly Ala Arg Gln His Pro Gly His Glu Thr Ala 
            20                  25                  30          


Ala Gln Arg Tyr Ser Ala Arg Leu Leu Gln Ala Gly Tyr Glu Pro Glu 
        35                  40                  45              


Ser Met Ala Asp Tyr Leu Ile Ser Gly Gly Thr Gly Tyr Val Pro Glu 
    50                  55                  60                  


Asp Gly Leu Thr Ala Gln Gln Leu Phe Ala Ser Ala Asp Gly Leu Thr 
65                  70                  75                  80  


Tyr Asn Asp Phe Leu Ile Leu Pro Gly Phe Ile Asp Phe Ile Ala Asp 
                85                  90                  95      


Glu Val Asp Leu Thr Ser Ala Leu Thr Arg Lys Ile Thr Leu Lys Thr 
            100                 105                 110         


Pro Leu Ile Ser Ser Pro Met Asp Thr Val Thr Glu Ala Asp Met Ala 
        115                 120                 125             


Ile Ala Met Ala Leu Met Gly Gly Ile Gly Phe Ile His His Asn Cys 
    130                 135                 140                 


Thr Pro Glu Phe Gln Ala Asn Glu Val Arg Lys Val Lys Lys Phe Glu 
145                 150                 155                 160 


Gln Gly Phe Ile Thr Asp Pro Val Val Leu Ser Pro Ser His Thr Val 
                165                 170                 175     


Gly Asp Val Leu Glu Ala Lys Met Arg His Gly Phe Ser Gly Ile Pro 
            180                 185                 190         


Ile Thr Glu Thr Gly Thr Met Gly Ser Lys Leu Val Gly Ile Val Thr 
        195                 200                 205             


Ser Arg Asp Ile Asp Phe Leu Ala Glu Lys Asp His Thr Thr Leu Leu 
    210                 215                 220                 


Ser Glu Val Met Thr Pro Arg Ile Glu Leu Val Val Ala Pro Ala Gly 
225                 230                 235                 240 


Val Thr Leu Lys Glu Ala Asn Glu Ile Leu Gln Arg Ser Lys Lys Gly 
                245                 250                 255     


Lys Leu Pro Ile Val Asn Asp Cys Asp Glu Leu Val Ala Ile Ile Ala 
            260                 265                 270         


Arg Thr Asp Leu Lys Lys Asn Arg Asp Tyr Pro Leu Ala Ser Lys Asp 
        275                 280                 285             


Ser Gln Lys Gln Leu Leu Cys Gly Ala Ala Val Gly Thr Arg Glu Asp 
    290                 295                 300                 


Asp Lys Tyr Arg Leu Asp Leu Leu Thr Gln Ala Gly Val Asp Val Ile 
305                 310                 315                 320 


Val Leu Asp Ser Ser Gln Gly Asn Ser Val Tyr Gln Ile Ala Met Val 
                325                 330                 335     


His Tyr Ile Lys Gln Lys Tyr Pro His Leu Gln Val Ile Gly Gly Asn 
            340                 345                 350         


Val Val Thr Ala Ala Gln Ala Lys Asn Leu Ile Asp Ala Gly Val Asp 
        355                 360                 365             


Gly Leu Arg Val Gly Met Gly Cys Gly Ser Ile Cys Ile Thr Gln Glu 
    370                 375                 380                 


Val Met Ala Cys Gly Arg Pro Gln Gly Thr Ala Val Tyr Lys Val Ala 
385                 390                 395                 400 


Glu Tyr Ala Arg Arg Phe Gly Val Pro Ile Ile Ala Asp Gly Gly Ile 
                405                 410                 415     


Gln Thr Val Gly His Val Val Lys Ala Leu Ala Leu Gly Ala Ser Thr 
            420                 425                 430         


Val Met Met Gly Ser Leu Leu Ala Ala Thr Thr Glu Ala Pro Gly Glu 
        435                 440                 445             


Tyr Phe Phe Ser Asp Gly Val Arg Leu Lys Lys Tyr Arg Gly Met Gly 
    450                 455                 460                 


Ser Leu Asp Ala Met Glu Lys Ser Ser Ser Ser Gln Lys Arg Tyr Phe 
465                 470                 475                 480 


Ser Glu Gly Asp Lys Val Lys Ile Ala Gln Gly Val Ser Gly Ser Ile 
                485                 490                 495     


Gln Asp Lys Gly Ser Ile Gln Lys Phe Val Pro Tyr Leu Ile Ala Gly 
            500                 505                 510         


Ile Gln His Gly Cys Gln Asp Ile Gly Ala Arg Ser Leu Ser Val Leu 
        515                 520                 525             


Arg Ser Met Met Tyr Ser Gly Glu Leu Lys Phe Glu Lys Arg Thr Met 
    530                 535                 540                 


Ser Ala Gln Ile Glu Gly Gly Val His Gly Leu His Ser Tyr Glu Lys 
545                 550                 555                 560 


Arg Leu Tyr 
            


<210>  442
<211>  261
<212>  PRT
<213>  Homo sapiens

<400>  442

Met Trp Val Pro Val Val Phe Leu Thr Leu Ser Val Thr Trp Ile Gly 
1               5                   10                  15      


Ala Ala Pro Leu Ile Leu Ser Arg Ile Val Gly Gly Trp Glu Cys Glu 
            20                  25                  30          


Lys His Ser Gln Pro Trp Gln Val Leu Val Ala Ser Arg Gly Arg Ala 
        35                  40                  45              


Val Cys Gly Gly Val Leu Val His Pro Gln Trp Val Leu Thr Ala Ala 
    50                  55                  60                  


His Cys Ile Arg Asn Lys Ser Val Ile Leu Leu Gly Arg His Ser Leu 
65                  70                  75                  80  


Phe His Pro Glu Asp Thr Gly Gln Val Phe Gln Val Ser His Ser Phe 
                85                  90                  95      


Pro His Pro Leu Tyr Asp Met Ser Leu Leu Lys Asn Arg Phe Leu Arg 
            100                 105                 110         


Pro Gly Asp Asp Ser Ser His Asp Leu Met Leu Leu Arg Leu Ser Glu 
        115                 120                 125             


Pro Ala Glu Leu Thr Asp Ala Val Lys Val Met Asp Leu Pro Thr Gln 
    130                 135                 140                 


Glu Pro Ala Leu Gly Thr Thr Cys Tyr Ala Ser Gly Trp Gly Ser Ile 
145                 150                 155                 160 


Glu Pro Glu Glu Phe Leu Thr Pro Lys Lys Leu Gln Cys Val Asp Leu 
                165                 170                 175     


His Val Ile Ser Asn Asp Val Cys Ala Gln Val His Pro Gln Lys Val 
            180                 185                 190         


Thr Lys Phe Met Leu Cys Ala Gly Arg Trp Thr Gly Gly Lys Ser Thr 
        195                 200                 205             


Cys Ser Gly Asp Ser Gly Gly Pro Leu Val Cys Asn Gly Val Leu Gln 
    210                 215                 220                 


Gly Ile Thr Ser Trp Gly Ser Glu Pro Cys Ala Leu Pro Glu Arg Pro 
225                 230                 235                 240 


Ser Leu Tyr Thr Lys Val Val His Tyr Arg Lys Trp Ile Lys Asp Thr 
                245                 250                 255     


Ile Val Ala Asn Pro 
            260     


<210>  443
<211>  562
<212>  PRT
<213>  Homo sapiens

<400>  443

Met Ala Leu Ser Lys Ser Met His Ala Arg Asn Arg Tyr Lys Asp Lys 
1               5                   10                  15      


Pro Pro Asp Phe Ala Tyr Leu Ala Ser Lys Tyr Pro Asp Phe Lys Gln 
            20                  25                  30          


His Val Gln Ile Asn Leu Asn Gly Arg Val Ser Leu Asn Phe Lys Asp 
        35                  40                  45              


Pro Glu Ala Val Arg Ala Leu Thr Cys Thr Leu Leu Arg Glu Asp Phe 
    50                  55                  60                  


Gly Leu Ser Ile Asp Ile Pro Leu Glu Arg Leu Ile Pro Thr Val Pro 
65                  70                  75                  80  


Leu Arg Leu Asn Tyr Ile His Trp Val Glu Asp Leu Ile Gly His Gln 
                85                  90                  95      


Asp Ser Asp Lys Ser Thr Leu Arg Arg Gly Ile Asp Ile Gly Thr Gly 
            100                 105                 110         


Ala Ser Cys Ile Tyr Pro Leu Leu Gly Ala Thr Leu Asn Gly Trp Tyr 
        115                 120                 125             


Phe Leu Ala Thr Glu Val Asp Asp Met Cys Phe Asn Tyr Ala Lys Lys 
    130                 135                 140                 


Asn Val Glu Gln Asn Asn Leu Ser Asp Leu Ile Lys Val Val Lys Val 
145                 150                 155                 160 


Pro Gln Lys Thr Leu Leu Met Asp Ala Leu Lys Glu Glu Ser Glu Ile 
                165                 170                 175     


Ile Tyr Asp Phe Cys Met Cys Asn Pro Pro Phe Phe Ala Asn Gln Leu 
            180                 185                 190         


Glu Ala Lys Gly Val Asn Ser Arg Asn Pro Arg Arg Pro Pro Pro Ser 
        195                 200                 205             


Ser Val Asn Thr Gly Gly Ile Thr Glu Ile Met Ala Glu Gly Gly Glu 
    210                 215                 220                 


Leu Glu Phe Val Lys Arg Ile Ile His Asp Ser Leu Gln Leu Lys Lys 
225                 230                 235                 240 


Arg Leu Arg Trp Tyr Ser Cys Met Leu Gly Lys Lys Cys Ser Leu Ala 
                245                 250                 255     


Pro Leu Lys Glu Glu Leu Arg Ile Gln Gly Val Pro Lys Val Thr Tyr 
            260                 265                 270         


Thr Glu Phe Cys Gln Gly Arg Thr Met Arg Trp Ala Leu Ala Trp Ser 
        275                 280                 285             


Phe Tyr Asp Asp Val Thr Val Pro Ser Pro Pro Ser Lys Arg Arg Lys 
    290                 295                 300                 


Leu Glu Lys Pro Arg Lys Pro Ile Thr Phe Val Val Leu Ala Ser Val 
305                 310                 315                 320 


Met Lys Glu Leu Ser Leu Lys Ala Ser Pro Leu Arg Ser Glu Thr Ala 
                325                 330                 335     


Glu Gly Ile Val Val Val Thr Thr Trp Ile Glu Lys Ile Leu Thr Asp 
            340                 345                 350         


Leu Lys Val Gln His Lys Arg Val Pro Cys Gly Lys Glu Glu Val Ser 
        355                 360                 365             


Leu Phe Leu Thr Ala Ile Glu Asn Ser Trp Ile His Leu Arg Arg Lys 
    370                 375                 380                 


Lys Arg Glu Arg Val Arg Gln Leu Arg Glu Val Pro Arg Ala Pro Glu 
385                 390                 395                 400 


Asp Val Ile Gln Ala Leu Glu Glu Lys Lys Pro Thr Pro Lys Glu Ser 
                405                 410                 415     


Gly Asn Ser Gln Glu Leu Ala Arg Gly Pro Gln Glu Arg Thr Pro Cys 
            420                 425                 430         


Gly Pro Ala Leu Arg Glu Gly Glu Ala Ala Ala Val Glu Gly Pro Cys 
        435                 440                 445             


Pro Ser Gln Glu Ser Leu Ser Gln Glu Glu Asn Pro Glu Pro Thr Glu 
    450                 455                 460                 


Asp Glu Arg Ser Glu Glu Lys Gly Gly Val Glu Val Leu Glu Asn Cys 
465                 470                 475                 480 


Gln Gly Ser Ser Asn Gly Ala Gln Asp Gln Glu Ala Ser Glu Gln Phe 
                485                 490                 495     


Gly Ser Pro Val Ala Glu Arg Gly Lys Arg Leu Pro Gly Val Ala Gly 
            500                 505                 510         


Gln Tyr Leu Phe Lys Cys Leu Ile Asn Val Lys Lys Glu Val Asp Asp 
        515                 520                 525             


Ala Leu Val Glu Met His Trp Val Glu Gly Gln Asn Arg Asp Leu Met 
    530                 535                 540                 


Asn Gln Leu Cys Thr Tyr Ile Arg Asn Gln Ile Phe Arg Leu Val Ala 
545                 550                 555                 560 


Val Asn 
        


<210>  444
<211>  411
<212>  PRT
<213>  Homo sapiens

<400>  444

Met Asp Ala Ala Leu Leu His Ser Leu Leu Glu Ala Asn Cys Ser Leu 
1               5                   10                  15      


Ala Leu Ala Glu Glu Leu Leu Leu Asp Gly Trp Gly Pro Pro Leu Asp 
            20                  25                  30          


Pro Glu Gly Pro Tyr Ser Tyr Cys Asn Thr Thr Leu Asp Gln Ile Gly 
        35                  40                  45              


Thr Cys Trp Pro Arg Ser Ala Ala Gly Ala Leu Val Glu Arg Pro Cys 
    50                  55                  60                  


Pro Glu Tyr Phe Asn Gly Val Lys Tyr Asn Thr Thr Arg Asn Ala Tyr 
65                  70                  75                  80  


Arg Glu Cys Leu Glu Asn Gly Thr Trp Ala Ser Lys Ile Asn Tyr Ser 
                85                  90                  95      


Gln Cys Glu Pro Ile Leu Asp Asp Lys Gln Arg Lys Tyr Asp Leu His 
            100                 105                 110         


Tyr Arg Ile Ala Leu Val Val Asn Tyr Leu Gly His Cys Val Ser Val 
        115                 120                 125             


Ala Ala Leu Val Ala Ala Phe Leu Leu Phe Leu Ala Leu Arg Ser Ile 
    130                 135                 140                 


Arg Cys Leu Arg Asn Val Ile His Trp Asn Leu Ile Thr Thr Phe Ile 
145                 150                 155                 160 


Leu Arg Asn Val Met Trp Phe Leu Leu Gln Leu Val Asp His Glu Val 
                165                 170                 175     


His Glu Ser Asn Glu Val Trp Cys Arg Cys Ile Thr Thr Ile Phe Asn 
            180                 185                 190         


Tyr Phe Val Val Thr Asn Phe Phe Trp Met Phe Val Glu Gly Cys Tyr 
        195                 200                 205             


Leu His Thr Ala Ile Val Met Thr Tyr Ser Thr Glu Arg Leu Arg Lys 
    210                 215                 220                 


Cys Leu Phe Leu Phe Ile Gly Trp Cys Ile Pro Phe Pro Ile Ile Val 
225                 230                 235                 240 


Ala Trp Ala Ile Gly Lys Leu Tyr Tyr Glu Asn Glu Gln Cys Trp Phe 
                245                 250                 255     


Gly Lys Glu Pro Gly Asp Leu Val Asp Tyr Ile Tyr Gln Gly Pro Ile 
            260                 265                 270         


Ile Leu Val Leu Leu Ile Asn Phe Val Phe Leu Phe Asn Ile Val Arg 
        275                 280                 285             


Ile Leu Met Thr Lys Leu Arg Ala Ser Thr Thr Ser Glu Thr Ile Gln 
    290                 295                 300                 


Tyr Arg Lys Ala Val Lys Ala Thr Leu Val Leu Leu Pro Leu Leu Gly 
305                 310                 315                 320 


Ile Thr Tyr Met Leu Phe Phe Val Asn Pro Gly Glu Asp Asp Leu Ser 
                325                 330                 335     


Gln Ile Met Phe Ile Tyr Phe Asn Ser Phe Leu Gln Ser Phe Gln Gly 
            340                 345                 350         


Phe Phe Val Ser Val Phe Tyr Cys Phe Phe Asn Gly Glu Val Arg Ser 
        355                 360                 365             


Ala Val Arg Lys Arg Trp His Arg Trp Gln Asp His His Ser Leu Arg 
    370                 375                 380                 


Val Pro Met Ala Arg Ala Met Ser Ile Pro Thr Ser Pro Thr Arg Ile 
385                 390                 395                 400 


Ser Phe His Ser Ile Lys Gln Thr Ala Ala Val 
                405                 410     


<210>  445
<211>  167
<212>  PRT
<213>  Homo sapiens

<400>  445

Met Pro Glu Asp Val Lys Asn Phe Tyr Leu Met Thr Asn Gly Phe His 
1               5                   10                  15      


Met Thr Trp Ser Val Lys Leu Asp Glu His Ile Ile Pro Leu Gly Ser 
            20                  25                  30          


Met Ala Ile Asn Ser Ile Ser Lys Leu Thr Gln Leu Thr Gln Ser Ser 
        35                  40                  45              


Met Tyr Ser Leu Pro Asn Ala Pro Thr Leu Ala Asp Leu Glu Asp Asp 
    50                  55                  60                  


Thr His Glu Ala Ser Asp Asp Gln Pro Glu Lys Pro His Phe Asp Ser 
65                  70                  75                  80  


Arg Ser Val Ile Phe Glu Leu Asp Ser Cys Asn Gly Ser Gly Lys Val 
                85                  90                  95      


Cys Leu Val Tyr Lys Ser Gly Lys Pro Ala Leu Ala Glu Asp Thr Glu 
            100                 105                 110         


Ile Trp Phe Leu Asp Arg Ala Leu Tyr Trp His Phe Leu Thr Asp Thr 
        115                 120                 125             


Phe Thr Ala Tyr Tyr Arg Leu Leu Ile Thr His Leu Gly Leu Pro Gln 
    130                 135                 140                 


Trp Gln Tyr Ala Phe Thr Ser Tyr Gly Ile Ser Pro Gln Ala Lys Val 
145                 150                 155                 160 


Arg Glu Glu His Leu Pro Leu 
                165         


<210>  446
<211>  1042
<212>  PRT
<213>  Homo sapiens

<400>  446

Met Glu Leu Gln Lys Gly Lys Gly Ala Ala Ala Ala Ala Ala Ala Ser 
1               5                   10                  15      


Gly Ala Ala Gly Gly Gly Gly Gly Gly Ala Gly Ala Gly Ala Pro Gly 
            20                  25                  30          


Gly Gly Arg Leu Leu Leu Ser Thr Ser Leu Asp Ala Lys Asp Glu Leu 
        35                  40                  45              


Glu Glu Arg Leu Glu Arg Cys Met Ser Ile Val Thr Ser Met Thr Ala 
    50                  55                  60                  


Gly Val Ser Glu Arg Glu Ala Asn Asp Ala Leu Asn Ala Tyr Val Cys 
65                  70                  75                  80  


Lys Gly Leu Pro Gln His Glu Glu Ile Cys Leu Gly Leu Phe Thr Leu 
                85                  90                  95      


Ile Leu Thr Glu Pro Ala Gln Ala Gln Lys Cys Tyr Arg Asp Leu Ala 
            100                 105                 110         


Leu Val Ser Arg Asp Gly Met Asn Ile Val Leu Asn Lys Ile Asn Gln 
        115                 120                 125             


Ile Leu Met Glu Lys Tyr Leu Lys Leu Gln Asp Thr Cys Arg Thr Gln 
    130                 135                 140                 


Leu Val Trp Leu Val Arg Glu Leu Val Lys Ser Gly Val Leu Gly Ala 
145                 150                 155                 160 


Asp Gly Val Cys Met Thr Phe Met Lys Gln Ile Ala Gly Gly Asp Val 
                165                 170                 175     


Thr Ala Lys Asn Ile Trp Leu Ala Glu Ser Val Leu Asp Ile Leu Thr 
            180                 185                 190         


Glu Gln Arg Glu Trp Val Leu Lys Ser Ser Ile Leu Ile Ala Met Ala 
        195                 200                 205             


Val Tyr Thr Tyr Leu Arg Leu Ile Val Asp His His Gly Thr Ala Gln 
    210                 215                 220                 


Leu Gln Ala Leu Arg Gln Lys Glu Val Asp Phe Cys Ile Ser Leu Leu 
225                 230                 235                 240 


Arg Glu Arg Phe Met Glu Cys Leu Met Ile Gly Arg Asp Leu Val Arg 
                245                 250                 255     


Leu Leu Gln Asn Val Ala Arg Ile Pro Glu Phe Glu Leu Leu Trp Lys 
            260                 265                 270         


Asp Ile Ile His Asn Pro Gln Ala Leu Ser Pro Gln Phe Thr Gly Ile 
        275                 280                 285             


Leu Gln Leu Leu Gln Ser Arg Thr Ser Arg Lys Phe Leu Ala Cys Arg 
    290                 295                 300                 


Leu Thr Pro Asp Met Glu Thr Lys Leu Leu Phe Met Thr Ser Arg Val 
305                 310                 315                 320 


Arg Phe Gly Gln Gln Lys Arg Tyr Gln Asp Trp Phe Gln Arg Gln Tyr 
                325                 330                 335     


Leu Ser Thr Pro Asp Ser Gln Ser Leu Arg Cys Asp Leu Ile Arg Tyr 
            340                 345                 350         


Ile Cys Gly Val Val His Pro Ser Asn Glu Val Leu Ser Ser Asp Ile 
        355                 360                 365             


Leu Pro Arg Trp Ala Ile Ile Gly Trp Leu Leu Thr Thr Cys Thr Ser 
    370                 375                 380                 


Asn Val Ala Ala Ser Asn Ala Lys Leu Ala Leu Phe Tyr Asp Trp Leu 
385                 390                 395                 400 


Phe Phe Ser Pro Asp Lys Asp Ser Ile Met Asn Ile Glu Pro Ala Ile 
                405                 410                 415     


Leu Val Met His His Ser Met Lys Pro His Pro Ala Ile Thr Ala Thr 
            420                 425                 430         


Leu Leu Asp Phe Met Cys Arg Ile Ile Pro Asn Phe Tyr Pro Pro Leu 
        435                 440                 445             


Glu Gly His Val Arg Gln Gly Val Phe Ser Ser Leu Asn His Ile Val 
    450                 455                 460                 


Glu Lys Arg Val Leu Ala His Leu Ala Pro Leu Phe Asp Asn Pro Lys 
465                 470                 475                 480 


Leu Asp Lys Glu Leu Arg Ala Met Leu Arg Glu Lys Phe Pro Glu Phe 
                485                 490                 495     


Cys Ser Ser Pro Ser Pro Pro Val Glu Val Lys Ile Glu Glu Pro Val 
            500                 505                 510         


Ser Met Glu Met Asp Asn His Met Ser Asp Lys Asp Glu Ser Cys Tyr 
        515                 520                 525             


Asp Asn Ala Glu Ala Ala Phe Ser Asp Asp Glu Glu Asp Leu Asn Ser 
    530                 535                 540                 


Lys Gly Lys Lys Arg Glu Phe Arg Phe His Pro Ile Lys Glu Thr Val 
545                 550                 555                 560 


Val Glu Glu Pro Val Asp Ile Thr Pro Tyr Leu Asp Gln Leu Asp Glu 
                565                 570                 575     


Ser Leu Arg Asp Lys Val Leu Gln Leu Gln Lys Gly Ser Asp Thr Glu 
            580                 585                 590         


Ala Gln Cys Glu Val Met Gln Glu Ile Val Asp Gln Val Leu Glu Glu 
        595                 600                 605             


Asp Phe Asp Ser Glu Gln Leu Ser Val Leu Ala Ser Cys Leu Gln Glu 
    610                 615                 620                 


Leu Phe Lys Ala His Phe Arg Gly Glu Val Leu Pro Glu Glu Ile Thr 
625                 630                 635                 640 


Glu Glu Ser Leu Glu Glu Ser Val Gly Lys Pro Leu Tyr Leu Ile Phe 
                645                 650                 655     


Arg Asn Leu Cys Gln Met Gln Glu Asp Asn Ser Ser Phe Ser Leu Leu 
            660                 665                 670         


Leu Asp Leu Leu Ser Glu Leu Tyr Gln Lys Gln Pro Lys Ile Gly Tyr 
        675                 680                 685             


His Leu Leu Tyr Tyr Leu Arg Ala Ser Lys Ala Ala Ala Gly Lys Met 
    690                 695                 700                 


Asn Leu Tyr Glu Ser Phe Ala Gln Ala Thr Gln Leu Gly Asp Leu His 
705                 710                 715                 720 


Thr Cys Leu Met Met Asp Met Lys Ala Cys Gln Glu Asp Asp Val Arg 
                725                 730                 735     


Leu Leu Cys His Leu Thr Pro Ser Ile Tyr Thr Glu Phe Pro Asp Glu 
            740                 745                 750         


Thr Leu Arg Ser Gly Glu Leu Leu Asn Met Ile Val Ala Val Ile Asp 
        755                 760                 765             


Ser Ala Gln Leu Gln Glu Leu Val Cys His Val Met Met Gly Asn Leu 
    770                 775                 780                 


Val Met Phe Arg Lys Asp Ser Val Leu Asn Ile Leu Ile Gln Ser Leu 
785                 790                 795                 800 


Asp Trp Glu Thr Phe Glu Gln Tyr Cys Ala Trp Gln Leu Phe Leu Ala 
                805                 810                 815     


His Asn Ile Pro Leu Glu Thr Ile Ile Pro Ile Leu Gln His Leu Lys 
            820                 825                 830         


Tyr Lys Glu His Pro Glu Ala Leu Ser Cys Leu Leu Leu Gln Leu Arg 
        835                 840                 845             


Arg Glu Lys Pro Ser Glu Glu Met Val Lys Met Val Leu Ser Arg Pro 
    850                 855                 860                 


Cys His Pro Asp Asp Gln Phe Thr Thr Ser Ile Leu Arg His Trp Cys 
865                 870                 875                 880 


Met Lys His Asp Glu Leu Leu Ala Glu His Ile Lys Ser Leu Leu Ile 
                885                 890                 895     


Lys Asn Asn Ser Leu Pro Arg Lys Arg Gln Ser Leu Arg Ser Ser Ser 
            900                 905                 910         


Ser Lys Leu Ala Gln Leu Thr Leu Glu Gln Ile Leu Glu His Leu Asp 
        915                 920                 925             


Asn Leu Arg Leu Asn Leu Thr Asn Thr Lys Gln Asn Phe Phe Ser Gln 
    930                 935                 940                 


Thr Pro Ile Leu Gln Ala Leu Gln His Val Gln Ala Ser Cys Asp Glu 
945                 950                 955                 960 


Ala His Lys Met Lys Phe Ser Asp Leu Phe Ser Leu Ala Glu Glu Tyr 
                965                 970                 975     


Glu Asp Ser Ser Thr Lys Pro Pro Lys Ser Arg Arg Lys Ala Ala Leu 
            980                 985                 990         


Ser Ser Pro Arg Ser Arg Lys Asn  Ala Thr Gln Pro Pro  Asn Ala Glu 
        995                 1000                 1005             


Glu Glu  Ser Gly Ser Ser Ser  Ala Ser Glu Glu Glu  Asp Thr Lys 
    1010                 1015                 1020             


Pro Lys  Pro Thr Lys Arg Lys  Arg Lys Gly Ser Ser  Ala Val Gly 
    1025                 1030                 1035             


Ser Asp  Ser Asp 
    1040         


<210>  447
<211>  483
<212>  PRT
<213>  Homo sapiens

<400>  447

Met Ala Gln Ala Asp Ile Ala Leu Ile Gly Leu Ala Val Met Gly Gln 
1               5                   10                  15      


Asn Leu Ile Leu Asn Met Asn Asp His Gly Phe Val Val Cys Ala Phe 
            20                  25                  30          


Asn Arg Thr Val Ser Lys Val Asp Asp Phe Leu Ala Asn Glu Ala Lys 
        35                  40                  45              


Gly Thr Lys Val Val Gly Ala Gln Ser Leu Lys Glu Met Val Ser Lys 
    50                  55                  60                  


Leu Lys Lys Pro Arg Arg Ile Ile Leu Leu Val Lys Ala Gly Gln Ala 
65                  70                  75                  80  


Val Asp Asp Phe Ile Glu Lys Leu Val Pro Leu Leu Asp Thr Gly Asp 
                85                  90                  95      


Ile Ile Ile Asp Gly Gly Asn Ser Glu Tyr Arg Asp Thr Thr Arg Arg 
            100                 105                 110         


Cys Arg Asp Leu Lys Ala Lys Gly Ile Leu Phe Val Gly Ser Gly Val 
        115                 120                 125             


Ser Gly Gly Glu Glu Gly Ala Arg Tyr Gly Pro Ser Leu Met Pro Gly 
    130                 135                 140                 


Gly Asn Lys Glu Ala Trp Pro His Ile Lys Thr Ile Phe Gln Gly Ile 
145                 150                 155                 160 


Ala Ala Lys Val Gly Thr Gly Glu Pro Cys Cys Asp Trp Val Gly Asp 
                165                 170                 175     


Glu Gly Ala Gly His Phe Val Lys Met Val His Asn Gly Ile Glu Tyr 
            180                 185                 190         


Gly Asp Met Gln Leu Ile Cys Glu Ala Tyr His Leu Met Lys Asp Val 
        195                 200                 205             


Leu Gly Met Ala Gln Asp Glu Met Ala Gln Ala Phe Glu Asp Trp Asn 
    210                 215                 220                 


Lys Thr Glu Leu Asp Ser Phe Leu Ile Glu Ile Thr Ala Asn Ile Leu 
225                 230                 235                 240 


Lys Phe Gln Asp Thr Asp Gly Lys His Leu Leu Pro Lys Ile Arg Asp 
                245                 250                 255     


Ser Ala Gly Gln Lys Gly Thr Gly Lys Trp Thr Ala Ile Ser Ala Leu 
            260                 265                 270         


Glu Tyr Gly Val Pro Val Thr Leu Ile Gly Glu Ala Val Phe Ala Arg 
        275                 280                 285             


Cys Leu Ser Ser Leu Lys Asp Glu Arg Ile Gln Ala Ser Lys Lys Leu 
    290                 295                 300                 


Lys Gly Pro Gln Lys Phe Gln Phe Asp Gly Asp Lys Lys Ser Phe Leu 
305                 310                 315                 320 


Glu Asp Ile Arg Lys Ala Leu Tyr Ala Ser Lys Ile Ile Ser Tyr Ala 
                325                 330                 335     


Gln Gly Phe Met Leu Leu Arg Gln Ala Ala Thr Glu Phe Gly Trp Thr 
            340                 345                 350         


Leu Asn Tyr Gly Gly Ile Ala Leu Met Trp Arg Gly Gly Cys Ile Ile 
        355                 360                 365             


Arg Ser Val Phe Leu Gly Lys Ile Lys Asp Ala Phe Asp Arg Asn Pro 
    370                 375                 380                 


Glu Leu Gln Asn Leu Leu Leu Asp Asp Phe Phe Lys Ser Ala Val Glu 
385                 390                 395                 400 


Asn Cys Gln Asp Ser Trp Arg Arg Ala Val Ser Thr Gly Val Gln Ala 
                405                 410                 415     


Gly Ile Pro Met Pro Cys Phe Thr Thr Ala Leu Ser Phe Tyr Asp Gly 
            420                 425                 430         


Tyr Arg His Glu Met Leu Pro Ala Ser Leu Ile Gln Ala Gln Arg Asp 
        435                 440                 445             


Tyr Phe Gly Ala His Thr Tyr Glu Leu Leu Ala Lys Pro Gly Gln Phe 
    450                 455                 460                 


Ile His Thr Asn Trp Thr Gly His Gly Gly Thr Val Ser Ser Ser Ser 
465                 470                 475                 480 


Tyr Asn Ala 
            


<210>  448
<211>  381
<212>  PRT
<213>  Homo sapiens

<400>  448

Met Gly Pro Ile Gly Ala Glu Ala Asp Glu Asn Gln Thr Val Glu Glu 
1               5                   10                  15      


Met Lys Val Glu Gln Tyr Gly Pro Gln Thr Thr Pro Arg Gly Glu Leu 
            20                  25                  30          


Val Pro Asp Pro Glu Pro Glu Leu Ile Asp Ser Thr Lys Leu Ile Glu 
        35                  40                  45              


Val Gln Val Val Leu Ile Leu Ala Tyr Cys Ser Ile Ile Leu Leu Gly 
    50                  55                  60                  


Val Ile Gly Asn Ser Leu Val Ile His Val Val Ile Lys Phe Lys Ser 
65                  70                  75                  80  


Met Arg Thr Val Thr Asn Phe Phe Ile Ala Asn Leu Ala Val Ala Asp 
                85                  90                  95      


Leu Leu Val Asn Thr Leu Cys Leu Pro Phe Thr Leu Thr Tyr Thr Leu 
            100                 105                 110         


Met Gly Glu Trp Lys Met Gly Pro Val Leu Cys His Leu Val Pro Tyr 
        115                 120                 125             


Ala Gln Gly Leu Ala Val Gln Val Ser Thr Ile Thr Leu Thr Val Ile 
    130                 135                 140                 


Ala Leu Asp Arg His Arg Cys Ile Val Tyr His Leu Glu Ser Lys Ile 
145                 150                 155                 160 


Ser Lys Arg Ile Ser Phe Leu Ile Ile Gly Leu Ala Trp Gly Ile Ser 
                165                 170                 175     


Ala Leu Leu Ala Ser Pro Leu Ala Ile Phe Arg Glu Tyr Ser Leu Ile 
            180                 185                 190         


Glu Ile Ile Pro Asp Phe Glu Ile Val Ala Cys Thr Glu Lys Trp Pro 
        195                 200                 205             


Gly Glu Glu Lys Ser Ile Tyr Gly Thr Val Tyr Ser Leu Ser Ser Leu 
    210                 215                 220                 


Leu Ile Leu Tyr Val Leu Pro Leu Gly Ile Ile Ser Phe Ser Tyr Thr 
225                 230                 235                 240 


Arg Ile Trp Ser Lys Leu Lys Asn His Val Ser Pro Gly Ala Ala Asn 
                245                 250                 255     


Asp His Tyr His Gln Arg Arg Gln Lys Thr Thr Lys Met Leu Val Cys 
            260                 265                 270         


Val Val Val Val Phe Ala Val Ser Trp Leu Pro Leu His Ala Phe Gln 
        275                 280                 285             


Leu Ala Val Asp Ile Asp Ser Gln Val Leu Asp Leu Lys Glu Tyr Lys 
    290                 295                 300                 


Leu Ile Phe Thr Val Phe His Ile Ile Ala Met Cys Ser Thr Phe Ala 
305                 310                 315                 320 


Asn Pro Leu Leu Tyr Gly Trp Met Asn Ser Asn Tyr Arg Lys Ala Phe 
                325                 330                 335     


Leu Ser Ala Phe Arg Cys Glu Gln Arg Leu Asp Ala Ile His Ser Glu 
            340                 345                 350         


Val Ser Val Thr Phe Lys Ala Lys Lys Asn Leu Glu Val Arg Lys Asn 
        355                 360                 365             


Ser Gly Pro Asn Asp Ser Phe Thr Glu Ala Thr Asn Val 
    370                 375                 380     


<210>  449
<211>  301
<212>  PRT
<213>  Homo sapiens

<400>  449

Met Leu Ser Glu Gly Tyr Leu Ser Gly Leu Glu Tyr Trp Asn Asp Ile 
1               5                   10                  15      


His Trp Ser Cys Ala Ser Tyr Asn Glu Gln Val Ala Gly Glu Lys Glu 
            20                  25                  30          


Glu Glu Thr Asn Ser Val Ala Thr Leu Ser Tyr Ser Ser Val Asp Glu 
        35                  40                  45              


Thr Gln Val Arg Ser Leu Tyr Val Ser Cys Lys Ser Ser Gly Lys Phe 
    50                  55                  60                  


Ile Ser Ser Val His Ser Arg Glu Ser Gln His Ser Arg Ser Gln Arg 
65                  70                  75                  80  


Val Thr Val Leu Gln Thr Asn Pro Asn Pro Val Phe Glu Ser Pro Asn 
                85                  90                  95      


Leu Ala Ala Val Glu Ile Cys Arg Asp Ala Ser Arg Glu Thr Tyr Leu 
            100                 105                 110         


Val Pro Ser Ser Cys Lys Ser Ile Cys Lys Asn Tyr Asn Asp Leu Gln 
        115                 120                 125             


Ile Ala Gly Gly Gln Val Met Ala Ile Asn Ser Val Thr Thr Asp Phe 
    130                 135                 140                 


Pro Ser Glu Ser Ser Phe Glu Tyr Gly Pro Leu Leu Lys Ser Ser Glu 
145                 150                 155                 160 


Ile Pro Leu Pro Met Glu Asp Ser Ile Ser Thr Gln Pro Ser Asp Phe 
                165                 170                 175     


Pro Gln Lys Pro Ile Gln Arg Tyr Ser Ser Tyr Trp Arg Ile Thr Ser 
            180                 185                 190         


Ile Lys Glu Lys Ser Ser Leu Gln Met Gln Asn Pro Ile Ser Asn Ala 
        195                 200                 205             


Val Leu Asn Glu Tyr Leu Glu Gln Lys Val Val Glu Leu Tyr Lys Gln 
    210                 215                 220                 


Tyr Ile Met Asp Thr Val Phe His Asp Ser Ser Pro Thr Gln Ile Leu 
225                 230                 235                 240 


Ala Ser Glu Leu Ile Met Thr Ser Val Asp Gln Ile Ser Leu Gln Val 
                245                 250                 255     


Ser Arg Glu Lys Asn Leu Glu Thr Ser Lys Ala Arg Asp Ile Val Phe 
            260                 265                 270         


Ser Arg Leu Leu Gln Leu Met Ser Thr Glu Ile Thr Glu Ile Ser Thr 
        275                 280                 285             


Pro Ser Leu His Ile Ser Gln Tyr Ser Asn Val Asn Pro 
    290                 295                 300     


<210>  450
<211>  346
<212>  PRT
<213>  Homo sapiens

<400>  450

Met Cys Glu Gly Pro Ser Arg Ile Ser Gly Pro Ile Pro Pro Asp Pro 
1               5                   10                  15      


Thr Leu Cys Pro Asp Asn Tyr Arg Arg Pro Thr Ser Ala Gln Gly Arg 
            20                  25                  30          


Leu Glu Gly Asn Ala Leu Lys Leu Asp Leu Leu Thr Ser Asp Arg Ala 
        35                  40                  45              


Leu Asp Thr Thr Ala Pro Arg Gly Pro Cys Ile Gly Pro Gly Ala Gly 
    50                  55                  60                  


Glu Ile Leu Glu Arg Gly Gln Arg Gly Val Gly Asp Val Leu Leu Gln 
65                  70                  75                  80  


Leu Glu Gly Ile Ser Leu Gly Pro Gly Ala Ser Leu Lys Arg Lys Asp 
                85                  90                  95      


Pro Lys Asp His Glu Lys Glu Asn Leu Arg Arg Ile Arg Glu Ile Gln 
            100                 105                 110         


Lys Arg Phe Arg Glu Gln Glu Arg Ser Arg Glu Gln Gly Gln Pro Arg 
        115                 120                 125             


Pro Leu Lys Ala Leu Trp Arg Ser Pro Lys Tyr Asp Lys Val Glu Ser 
    130                 135                 140                 


Arg Val Lys Ala Gln Leu Gln Glu Pro Gly Pro Ala Ser Gly Thr Glu 
145                 150                 155                 160 


Ser Ala His Phe Leu Arg Ala His Ser Arg Cys Gly Pro Gly Leu Pro 
                165                 170                 175     


Pro Pro His Val Ser Ser Pro Gln Pro Thr Pro Pro Gly Pro Glu Ala 
            180                 185                 190         


Lys Glu Pro Gly Leu Gly Val Asp Phe Ile Arg His Asn Ala Arg Ala 
        195                 200                 205             


Ala Lys Arg Ala Pro Arg Arg His Ser Cys Ser Leu Gln Val Leu Ala 
    210                 215                 220                 


Gln Val Leu Glu Gln Gln Arg Gln Ala Gln Glu His Tyr Asn Ala Thr 
225                 230                 235                 240 


Gln Lys Gly His Val Pro His Tyr Leu Leu Glu Arg Arg Asp Leu Trp 
                245                 250                 255     


Arg Arg Glu Ala Glu Ala Arg Lys Gln Ser Gln Pro Asp Pro Ala Met 
            260                 265                 270         


Pro Pro Gly His Thr Arg Met Pro Glu Asn Gln Arg Leu Glu Thr Leu 
        275                 280                 285             


Thr Lys Leu Leu Gln Ser Gln Ser Gln Leu Leu Arg Glu Leu Val Leu 
    290                 295                 300                 


Leu Pro Ala Gly Ala Asp Ser Leu Arg Ala Gln Ser His Arg Ala Glu 
305                 310                 315                 320 


Leu Asp Arg Lys Leu Val Gln Val Glu Glu Ala Ile Lys Ile Phe Ser 
                325                 330                 335     


Arg Pro Lys Val Phe Val Lys Met Asp Asp 
            340                 345     


<210>  451
<211>  729
<212>  PRT
<213>  Homo sapiens

<400>  451

Met Ser Thr Arg Thr Pro Leu Pro Thr Val Asn Glu Arg Asp Thr Glu 
1               5                   10                  15      


Asn His Thr Ser His Gly Asp Gly Arg Gln Glu Val Thr Ser Arg Thr 
            20                  25                  30          


Ser Arg Ser Gly Ala Arg Cys Arg Asn Ser Ile Ala Ser Cys Ala Asp 
        35                  40                  45              


Glu Gln Pro His Ile Gly Asn Tyr Arg Leu Leu Lys Thr Ile Gly Lys 
    50                  55                  60                  


Gly Asn Phe Ala Lys Val Lys Leu Ala Arg His Ile Leu Thr Gly Arg 
65                  70                  75                  80  


Glu Val Ala Ile Lys Ile Ile Asp Lys Thr Gln Leu Asn Pro Thr Ser 
                85                  90                  95      


Leu Gln Lys Leu Phe Arg Glu Val Arg Ile Met Lys Ile Leu Asn His 
            100                 105                 110         


Pro Asn Ile Val Lys Leu Phe Glu Val Ile Glu Thr Glu Lys Thr Leu 
        115                 120                 125             


Tyr Leu Ile Met Glu Tyr Ala Ser Gly Gly Glu Val Phe Asp Tyr Leu 
    130                 135                 140                 


Val Ala His Gly Arg Met Lys Glu Lys Glu Ala Arg Ser Lys Phe Arg 
145                 150                 155                 160 


Gln Ile Val Ser Ala Val Gln Tyr Cys His Gln Lys Arg Ile Val His 
                165                 170                 175     


Arg Asp Leu Lys Ala Glu Asn Leu Leu Leu Asp Ala Asp Met Asn Ile 
            180                 185                 190         


Lys Ile Ala Asp Phe Gly Phe Ser Asn Glu Phe Thr Val Gly Gly Lys 
        195                 200                 205             


Leu Asp Thr Phe Cys Gly Ser Pro Pro Tyr Ala Ala Pro Glu Leu Phe 
    210                 215                 220                 


Gln Gly Lys Lys Tyr Asp Gly Pro Glu Val Asp Val Trp Ser Leu Gly 
225                 230                 235                 240 


Val Ile Leu Tyr Thr Leu Val Ser Gly Ser Leu Pro Phe Asp Gly Gln 
                245                 250                 255     


Asn Leu Lys Glu Leu Arg Glu Arg Val Leu Arg Gly Lys Tyr Arg Ile 
            260                 265                 270         


Pro Phe Tyr Met Ser Thr Asp Cys Glu Asn Leu Leu Lys Arg Phe Leu 
        275                 280                 285             


Val Leu Asn Pro Ile Lys Arg Gly Thr Leu Glu Gln Ile Met Lys Asp 
    290                 295                 300                 


Arg Trp Ile Asn Ala Gly His Glu Glu Asp Glu Leu Lys Pro Phe Val 
305                 310                 315                 320 


Glu Pro Glu Leu Asp Ile Ser Asp Gln Lys Arg Ile Asp Ile Met Val 
                325                 330                 335     


Gly Met Gly Tyr Ser Gln Glu Glu Ile Gln Glu Ser Leu Ser Lys Met 
            340                 345                 350         


Lys Tyr Asp Glu Ile Thr Ala Thr Tyr Leu Leu Leu Gly Arg Lys Ser 
        355                 360                 365             


Ser Glu Leu Asp Ala Ser Asp Ser Ser Ser Ser Ser Asn Leu Ser Leu 
    370                 375                 380                 


Ala Lys Val Arg Pro Ser Ser Asp Leu Asn Asn Ser Thr Gly Gln Ser 
385                 390                 395                 400 


Pro His His Lys Val Gln Arg Ser Val Ser Ser Ser Gln Lys Gln Arg 
                405                 410                 415     


Arg Tyr Ser Asp His Ala Gly Pro Ala Ile Pro Ser Val Val Ala Tyr 
            420                 425                 430         


Pro Lys Arg Ser Gln Thr Ser Thr Ala Asp Ser Asp Leu Lys Glu Asp 
        435                 440                 445             


Gly Ile Ser Ser Arg Lys Ser Ser Gly Ser Ala Val Gly Gly Lys Gly 
    450                 455                 460                 


Ile Ala Pro Ala Ser Pro Met Leu Gly Asn Ala Ser Asn Pro Asn Lys 
465                 470                 475                 480 


Ala Asp Ile Pro Glu Arg Lys Lys Ser Ser Thr Val Pro Ser Ser Asn 
                485                 490                 495     


Thr Ala Ser Gly Gly Met Thr Arg Arg Asn Thr Tyr Val Cys Ser Glu 
            500                 505                 510         


Arg Thr Thr Ala Asp Arg His Ser Val Ile Gln Asn Gly Lys Glu Asn 
        515                 520                 525             


Ser Thr Ile Pro Asp Gln Arg Thr Pro Val Ala Ser Thr His Ser Ile 
    530                 535                 540                 


Ser Ser Ala Ala Thr Pro Asp Arg Ile Arg Phe Pro Arg Gly Thr Ala 
545                 550                 555                 560 


Ser Arg Ser Thr Phe His Gly Gln Pro Arg Glu Arg Arg Thr Ala Thr 
                565                 570                 575     


Tyr Asn Gly Pro Pro Ala Ser Pro Ser Leu Ser His Glu Ala Thr Pro 
            580                 585                 590         


Leu Ser Gln Thr Arg Ser Arg Gly Ser Thr Asn Leu Phe Ser Lys Leu 
        595                 600                 605             


Thr Ser Lys Leu Thr Arg Ser Arg Asn Val Ser Ala Glu Gln Lys Asp 
    610                 615                 620                 


Glu Asn Lys Glu Ala Lys Pro Arg Ser Leu Arg Phe Thr Trp Ser Met 
625                 630                 635                 640 


Lys Thr Thr Ser Ser Met Asp Pro Gly Asp Met Met Arg Glu Ile Arg 
                645                 650                 655     


Lys Val Leu Asp Ala Asn Asn Cys Asp Tyr Glu Gln Arg Glu Arg Phe 
            660                 665                 670         


Leu Leu Phe Cys Val His Gly Asp Gly His Ala Glu Asn Leu Val Gln 
        675                 680                 685             


Trp Glu Met Glu Val Cys Lys Leu Pro Arg Leu Ser Leu Asn Gly Val 
    690                 695                 700                 


Arg Phe Lys Arg Ile Ser Gly Thr Ser Ile Ala Phe Lys Asn Ile Ala 
705                 710                 715                 720 


Ser Lys Ile Ala Asn Glu Leu Lys Leu 
                725                 


<210>  452
<211>  364
<212>  PRT
<213>  Homo sapiens

<400>  452

Met Ser Ala Asn Ser Ser Arg Val Gly Gln Leu Leu Leu Gln Gly Ser 
1               5                   10                  15      


Ala Cys Ile Arg Trp Lys Gln Asp Val Glu Gly Ala Val Tyr His Leu 
            20                  25                  30          


Ala Asn Cys Leu Leu Leu Leu Gly Phe Met Gly Gly Ser Gly Val Tyr 
        35                  40                  45              


Gly Cys Phe Tyr Leu Phe Gly Phe Leu Ser Ala Gly Tyr Leu Cys Cys 
    50                  55                  60                  


Val Leu Trp Gly Trp Phe Ser Ala Cys Gly Leu Asp Ile Val Leu Trp 
65                  70                  75                  80  


Ser Phe Leu Leu Ala Val Val Cys Leu Leu Gln Leu Ala His Leu Val 
                85                  90                  95      


Tyr Arg Leu Arg Glu Asp Thr Leu Pro Glu Glu Phe Asp Leu Leu Tyr 
            100                 105                 110         


Lys Thr Leu Cys Leu Pro Leu Gln Val Pro Leu Gln Thr Tyr Lys Glu 
        115                 120                 125             


Ile Val His Cys Cys Glu Glu Gln Val Leu Thr Leu Ala Thr Glu Gln 
    130                 135                 140                 


Thr Tyr Ala Val Glu Gly Glu Thr Pro Ile Asn Arg Leu Ser Leu Leu 
145                 150                 155                 160 


Leu Ser Gly Arg Val Arg Val Ser Gln Asp Gly Gln Phe Leu His Tyr 
                165                 170                 175     


Ile Phe Pro Tyr Gln Phe Met Asp Ser Pro Glu Trp Glu Ser Leu Gln 
            180                 185                 190         


Pro Ser Glu Glu Gly Val Phe Gln Val Thr Leu Thr Ala Glu Thr Ser 
        195                 200                 205             


Cys Ser Tyr Ile Ser Trp Pro Arg Lys Ser Leu His Leu Leu Leu Thr 
    210                 215                 220                 


Lys Glu Arg Tyr Ile Ser Cys Leu Phe Ser Ala Leu Leu Gly Tyr Asp 
225                 230                 235                 240 


Ile Ser Glu Lys Leu Tyr Thr Leu Asn Asp Lys Leu Phe Ala Lys Phe 
                245                 250                 255     


Gly Leu Arg Phe Asp Ile Arg Leu Pro Ser Leu Tyr His Val Leu Gly 
            260                 265                 270         


Pro Thr Ala Ala Asp Ala Gly Pro Glu Ser Glu Lys Gly Asp Glu Glu 
        275                 280                 285             


Val Cys Glu Pro Ala Val Ser Pro Pro Gln Ala Thr Pro Thr Ser Leu 
    290                 295                 300                 


Gln Gln Thr Pro Pro Cys Ser Thr Pro Pro Ala Thr Thr Asn Phe Pro 
305                 310                 315                 320 


Ala Pro Pro Thr Arg Ala Arg Leu Ser Arg Pro Asp Ser Gly Ile Leu 
                325                 330                 335     


Ala Ser Arg Ile Pro Leu Gln Ser Tyr Ser Gln Val Ile Ser Arg Gly 
            340                 345                 350         


Gln Ala Pro Leu Ala Pro Thr His Thr Pro Glu Leu 
        355                 360                 


<210>  453
<211>  140
<212>  PRT
<213>  Homo sapiens

<400>  453

Met Asp Val Phe Met Lys Gly Leu Ser Lys Ala Lys Glu Gly Val Val 
1               5                   10                  15      


Ala Ala Ala Glu Lys Thr Lys Gln Gly Val Ala Glu Ala Ala Gly Lys 
            20                  25                  30          


Thr Lys Glu Gly Val Leu Tyr Val Gly Ser Lys Thr Lys Glu Gly Val 
        35                  40                  45              


Val His Gly Val Ala Thr Val Ala Glu Lys Thr Lys Glu Gln Val Thr 
    50                  55                  60                  


Asn Val Gly Gly Ala Val Val Thr Gly Val Thr Ala Val Ala Gln Lys 
65                  70                  75                  80  


Thr Val Glu Gly Ala Gly Ser Ile Ala Ala Ala Thr Gly Phe Val Lys 
                85                  90                  95      


Lys Asp Gln Leu Gly Lys Asn Glu Glu Gly Ala Pro Gln Glu Gly Ile 
            100                 105                 110         


Leu Glu Asp Met Pro Val Asp Pro Asp Asn Glu Ala Tyr Glu Met Pro 
        115                 120                 125             


Ser Glu Glu Gly Tyr Gln Asp Tyr Glu Pro Glu Ala 
    130                 135                 140 


<210>  454
<211>  336
<212>  PRT
<213>  Homo sapiens

<400>  454

His Asn Gln Thr Ser Leu Tyr Lys Lys Ala Gly Ser Ala Ala Ala Pro 
1               5                   10                  15      


Phe Thr Met Ser Lys Pro Pro Ala Pro Asn Pro Thr Pro Pro Arg Asn 
            20                  25                  30          


Leu Asp Ser Arg Thr Phe Ile Thr Ile Gly Asp Arg Asn Phe Glu Val 
        35                  40                  45              


Glu Ala Asp Asp Leu Val Thr Ile Ser Glu Leu Gly Arg Gly Ala Tyr 
    50                  55                  60                  


Gly Val Val Glu Lys Val Arg His Ala Gln Ser Gly Thr Ile Met Ala 
65                  70                  75                  80  


Val Lys Arg Ile Arg Ala Thr Val Asn Ser Gln Glu Gln Lys Arg Leu 
                85                  90                  95      


Leu Met Asp Leu Asp Ile Asn Met Arg Thr Val Asp Cys Phe Tyr Thr 
            100                 105                 110         


Val Thr Phe Tyr Gly Ala Leu Phe Arg Glu Gly Asp Val Trp Ile Cys 
        115                 120                 125             


Met Glu Leu Met Asp Thr Ser Leu Asp Lys Phe Tyr Arg Lys Val Leu 
    130                 135                 140                 


Asp Lys Asn Met Thr Ile Pro Glu Asp Ile Leu Gly Glu Ile Ala Val 
145                 150                 155                 160 


Ser Ile Val Arg Ala Leu Glu His Leu His Ser Lys Leu Ser Val Ile 
                165                 170                 175     


His Arg Asp Val Lys Pro Ser Asn Val Leu Ile Asn Lys Glu Gly His 
            180                 185                 190         


Val Lys Met Cys Asp Phe Gly Ile Ser Gly Tyr Leu Val Asp Ser Val 
        195                 200                 205             


Ala Lys Thr Met Asp Ala Gly Cys Lys Pro Tyr Met Ala Pro Glu Arg 
    210                 215                 220                 


Ile Asn Pro Glu Leu Asn Gln Lys Gly Tyr Asn Val Lys Ser Asp Val 
225                 230                 235                 240 


Trp Ser Leu Gly Ile Thr Met Ile Glu Met Ala Ile Leu Arg Phe Pro 
                245                 250                 255     


Tyr Glu Ser Trp Gly Thr Pro Phe Gln Gln Leu Lys Gln Val Val Glu 
            260                 265                 270         


Glu Pro Ser Pro Gln Leu Pro Ala Asp Arg Phe Ser Pro Glu Phe Val 
        275                 280                 285             


Asp Phe Thr Ala Gln Cys Leu Arg Lys Asn Pro Ala Glu Arg Met Ser 
    290                 295                 300                 


Tyr Leu Glu Leu Met Glu His Pro Phe Phe Thr Leu His Lys Thr Lys 
305                 310                 315                 320 


Lys Thr Asp Ile Ala Ala Phe Val Lys Glu Ile Leu Gly Glu Asp Ser 
                325                 330                 335     


<210>  455
<211>  579
<212>  PRT
<213>  Homo sapiens

<400>  455

Met Ala Gln Glu Val Ser Glu Tyr Leu Ser Gln Asn Pro Arg Val Ala 
1               5                   10                  15      


Ala Trp Val Glu Ala Leu Arg Cys Asp Gly Glu Thr Asp Lys His Trp 
            20                  25                  30          


Arg His Arg Arg Asp Phe Leu Leu Arg Asn Ala Gly Asp Leu Ala Pro 
        35                  40                  45              


Ala Gly Gly Ala Ala Ser Ala Ser Thr Asp Glu Ala Ala Asp Ala Glu 
    50                  55                  60                  


Ser Gly Thr Arg Asn Arg Gln Leu Gln Gln Leu Ile Ser Phe Ser Met 
65                  70                  75                  80  


Ala Trp Ala Asn His Val Phe Leu Gly Cys Arg Tyr Pro Gln Lys Val 
                85                  90                  95      


Met Asp Lys Ile Leu Ser Met Ala Glu Gly Ile Lys Val Thr Asp Ala 
            100                 105                 110         


Pro Thr Tyr Thr Thr Arg Asp Glu Leu Val Ala Lys Val Lys Lys Arg 
        115                 120                 125             


Gly Ile Ser Ser Ser Asn Glu Gly Val Glu Glu Pro Ser Lys Lys Arg 
    130                 135                 140                 


Val Ile Glu Gly Lys Asn Ser Ser Ala Val Glu Gln Asp His Ala Lys 
145                 150                 155                 160 


Thr Ser Ala Lys Thr Glu Arg Ala Ser Ala Gln Gln Glu Asn Ser Ser 
                165                 170                 175     


Thr Cys Ile Gly Ser Ala Ile Lys Ser Glu Ser Gly Asn Ser Ala Arg 
            180                 185                 190         


Ser Ser Gly Ile Ser Ser Gln Asn Ser Ser Thr Ser Asp Gly Asp Arg 
        195                 200                 205             


Ser Val Ser Ser Gln Ser Ser Ser Ser Val Ser Ser Gln Val Thr Thr 
    210                 215                 220                 


Ala Gly Ser Gly Lys Ala Ser Glu Ala Glu Ala Pro Asp Lys His Gly 
225                 230                 235                 240 


Ser Ser Phe Val Ser Leu Leu Lys Ser Ser Val Asn Ser His Met Thr 
                245                 250                 255     


Gln Ser Thr Asp Ser Arg Gln Gln Ser Gly Ser Pro Lys Lys Ser Ala 
            260                 265                 270         


Leu Glu Gly Ser Ser Ala Ser Ala Ser Gln Ser Ser Ser Glu Ile Glu 
        275                 280                 285             


Val Pro Leu Leu Gly Ser Ser Gly Ser Ser Glu Val Glu Leu Pro Leu 
    290                 295                 300                 


Leu Ser Ser Lys Pro Ser Ser Glu Thr Ala Ser Ser Gly Leu Thr Ser 
305                 310                 315                 320 


Lys Thr Ser Ser Glu Ala Ser Val Ser Ser Ser Val Ala Lys Asn Ser 
                325                 330                 335     


Ser Ser Ser Gly Thr Ser Leu Leu Thr Pro Lys Ser Ser Ser Ser Thr 
            340                 345                 350         


Asn Thr Ser Leu Leu Thr Ser Lys Ser Thr Ser Gln Val Ala Ala Ser 
        355                 360                 365             


Leu Leu Ala Ser Lys Ser Ser Ser Gln Thr Ser Gly Ser Leu Val Ser 
    370                 375                 380                 


Lys Ser Thr Ser Leu Ala Ser Val Ser Gln Leu Ala Ser Lys Ser Ser 
385                 390                 395                 400 


Ser Gln Thr Ser Thr Ser Gln Leu Pro Ser Lys Ser Thr Ser Gln Ser 
                405                 410                 415     


Ser Glu Ser Ser Val Lys Phe Ser Cys Lys Leu Thr Asn Glu Asp Val 
            420                 425                 430         


Lys Gln Lys Gln Pro Phe Phe Asn Arg Leu Tyr Lys Thr Val Ala Trp 
        435                 440                 445             


Lys Leu Val Ala Val Gly Gly Phe Ser Pro Asn Val Asn His Gly Glu 
    450                 455                 460                 


Leu Leu Asn Ala Ala Ile Glu Ala Leu Lys Ala Thr Leu Asp Val Phe 
465                 470                 475                 480 


Phe Val Pro Leu Lys Glu Leu Ala Asp Leu Pro Gln Asn Lys Ser Ser 
                485                 490                 495     


Gln Glu Ser Ile Val Cys Glu Leu Arg Cys Lys Ser Val Tyr Leu Gly 
            500                 505                 510         


Thr Gly Cys Gly Lys Ser Lys Glu Asn Ala Lys Ala Val Ala Ser Arg 
        515                 520                 525             


Glu Ala Leu Lys Leu Phe Leu Lys Lys Lys Val Val Val Lys Ile Cys 
    530                 535                 540                 


Lys Arg Lys Tyr Arg Gly Ser Glu Ile Glu Asp Leu Val Leu Leu Asp 
545                 550                 555                 560 


Glu Glu Ser Arg Pro Val Asn Leu Pro Pro Ala Leu Lys His Pro Gln 
                565                 570                 575     


Glu Leu Leu 
            


<210>  456
<211>  282
<212>  PRT
<213>  Homo sapiens

<400>  456

Met Asn Ser Ser Thr Ser Thr Met Ser Glu Glu Pro Asp Ala Leu Ser 
1               5                   10                  15      


Val Val Asn Gln Leu Arg Asp Leu Ala Ala Asp Pro Leu Asn Arg Arg 
            20                  25                  30          


Ala Ile Val Gln Asp Gln Gly Cys Leu Pro Gly Leu Ile Leu Phe Met 
        35                  40                  45              


Asp His Pro Asn Pro Pro Val Val His Ser Ala Leu Leu Ala Leu Arg 
    50                  55                  60                  


Tyr Leu Ala Glu Cys Arg Ala Asn Arg Glu Lys Met Lys Gly Glu Leu 
65                  70                  75                  80  


Gly Met Met Leu Ser Leu Gln Asn Val Ile Gln Lys Thr Thr Thr Pro 
                85                  90                  95      


Gly Glu Thr Lys Leu Leu Ala Ser Glu Ile Tyr Asp Ile Leu Gln Ser 
            100                 105                 110         


Ser Asn Met Ala Asp Gly Asp Ser Phe Asn Glu Met Asn Ser Arg Arg 
        115                 120                 125             


Arg Lys Ala Gln Phe Phe Leu Gly Thr Thr Asn Lys Arg Ala Lys Thr 
    130                 135                 140                 


Val Val Leu His Ile Asp Gly Leu Asp Asp Thr Ser Arg Arg Asn Leu 
145                 150                 155                 160 


Cys Glu Glu Ala Leu Leu Lys Ile Lys Gly Val Ile Ser Phe Thr Phe 
                165                 170                 175     


Gln Met Ala Val Gln Arg Cys Val Val Arg Ile Arg Ser Asp Leu Lys 
            180                 185                 190         


Ala Glu Ala Leu Ala Ser Ala Ile Ala Ser Thr Lys Val Met Lys Ala 
        195                 200                 205             


Gln Gln Val Val Lys Ser Glu Ser Gly Glu Glu Met Leu Val Pro Phe 
    210                 215                 220                 


Gln Asp Thr Pro Val Glu Val Glu Gln Asn Thr Glu Leu Pro Asp Tyr 
225                 230                 235                 240 


Leu Pro Glu Asp Glu Ser Pro Thr Lys Glu Gln Asp Lys Ala Val Ser 
                245                 250                 255     


Arg Val Gly Ser His Pro Glu Gly Gly Ala Ser Trp Leu Ser Thr Ala 
            260                 265                 270         


Ala Asn Phe Leu Ser Arg Ser Phe Tyr Trp 
        275                 280         


<210>  457
<211>  254
<212>  PRT
<213>  Homo sapiens

<400>  457

Met Ser Leu Ala Arg Gly His Gly Asp Thr Ala Ala Ser Thr Ala Ala 
1               5                   10                  15      


Pro Leu Ser Glu Glu Gly Glu Val Thr Ser Gly Leu Gln Ala Leu Ala 
            20                  25                  30          


Val Glu Asp Thr Gly Gly Pro Ser Ala Ser Ala Gly Lys Ala Glu Asp 
        35                  40                  45              


Glu Gly Glu Gly Gly Arg Glu Glu Thr Glu Arg Glu Gly Ser Gly Gly 
    50                  55                  60                  


Glu Glu Ala Gln Gly Glu Val Pro Ser Ala Gly Gly Glu Glu Pro Ala 
65                  70                  75                  80  


Glu Glu Asp Ser Glu Asp Trp Cys Val Pro Cys Ser Asp Glu Glu Val 
                85                  90                  95      


Glu Leu Pro Ala Asp Gly Gln Pro Trp Met Pro Pro Pro Ser Glu Ile 
            100                 105                 110         


Gln Arg Leu Tyr Glu Leu Leu Ala Ala His Gly Thr Leu Glu Leu Gln 
        115                 120                 125             


Ala Glu Ile Leu Pro Arg Arg Pro Pro Thr Pro Glu Ala Gln Ser Glu 
    130                 135                 140                 


Glu Glu Arg Ser Asp Glu Glu Pro Glu Ala Lys Glu Glu Glu Glu Glu 
145                 150                 155                 160 


Lys Pro His Met Pro Thr Glu Phe Asp Phe Asp Asp Glu Pro Val Thr 
                165                 170                 175     


Pro Lys Asp Ser Leu Ile Asp Arg Arg Arg Thr Pro Gly Ser Ser Ala 
            180                 185                 190         


Arg Ser Gln Lys Arg Glu Ala Arg Leu Asp Lys Val Leu Ser Asp Met 
        195                 200                 205             


Lys Arg His Lys Lys Leu Glu Glu Gln Ile Leu Arg Thr Gly Arg Asp 
    210                 215                 220                 


Leu Phe Ser Leu Asp Ser Glu Asp Pro Ser Pro Ala Ser Pro Pro Leu 
225                 230                 235                 240 


Arg Ser Ser Gly Ser Ser Leu Phe Pro Arg Gln Arg Lys Tyr 
                245                 250                 


<210>  458
<211>  263
<212>  PRT
<213>  Homo sapiens

<400>  458

Ile Asp Pro Lys Asp Leu Thr Phe Leu Lys Glu Leu Gly Thr Gly Gln 
1               5                   10                  15      


Phe Gly Val Val Lys Tyr Gly Lys Trp Arg Gly Gln Tyr Asp Val Ala 
            20                  25                  30          


Ile Lys Met Ile Lys Glu Gly Ser Met Ser Glu Asp Glu Phe Ile Glu 
        35                  40                  45              


Glu Ala Lys Val Met Met Asn Leu Ser His Glu Lys Leu Val Gln Leu 
    50                  55                  60                  


Tyr Gly Val Cys Thr Lys Gln Arg Pro Ile Phe Ile Ile Thr Glu Tyr 
65                  70                  75                  80  


Met Ala Asn Gly Cys Leu Leu Asn Tyr Leu Arg Glu Met Arg His Arg 
                85                  90                  95      


Phe Gln Thr Gln Gln Leu Leu Glu Met Cys Lys Asp Val Cys Glu Ala 
            100                 105                 110         


Met Glu Tyr Leu Glu Ser Lys Gln Phe Leu His Arg Asp Leu Ala Ala 
        115                 120                 125             


Arg Asn Cys Leu Val Asn Asp Gln Gly Val Val Lys Val Ser Asp Phe 
    130                 135                 140                 


Gly Leu Ser Arg Tyr Val Leu Asp Asp Glu Tyr Thr Ser Ser Val Gly 
145                 150                 155                 160 


Ser Lys Phe Pro Val Arg Trp Ser Pro Pro Glu Val Leu Met Tyr Ser 
                165                 170                 175     


Lys Phe Ser Ser Lys Ser Asp Ile Trp Ala Phe Gly Val Leu Met Trp 
            180                 185                 190         


Glu Ile Tyr Ser Leu Gly Lys Met Pro Tyr Glu Arg Phe Thr Asn Ser 
        195                 200                 205             


Glu Thr Ala Glu His Ile Ala Gln Gly Leu Arg Leu Tyr Arg Pro His 
    210                 215                 220                 


Leu Ala Ser Glu Lys Val Tyr Thr Ile Met Tyr Ser Cys Trp His Glu 
225                 230                 235                 240 


Lys Ala Asp Glu Arg Pro Thr Phe Lys Ile Leu Leu Ser Asn Ile Leu 
                245                 250                 255     


Asp Val Met Asp Glu Glu Ser 
            260             


<210>  459
<211>  255
<212>  PRT
<213>  Homo sapiens

<400>  459

Met Ser Glu Lys Leu Arg Arg Cys Arg Lys Glu Leu Thr Ala Ala Ile 
1               5                   10                  15      


Asp Arg Ala Phe Glu Gly Val Ser Tyr Ser Gln Glu Cys Thr Gly Gln 
            20                  25                  30          


Gln Arg Leu Glu Leu Ser Ala Ala Pro Leu Ser Phe Ser Leu Pro Val 
        35                  40                  45              


His Arg Leu Leu Cys Arg Arg His Pro Leu Ser Ala Cys Ser Ser Ala 
    50                  55                  60                  


Ala Pro Phe Ala Ala Val Pro Cys Ala Pro Glu Asn Glu Asn Pro Ala 
65                  70                  75                  80  


Phe Ala Thr Asn His Ala Pro Val Asn Ala Lys Pro His Ala Leu Cys 
                85                  90                  95      


Pro Glu Arg Lys Pro Leu Thr Ser Lys Glu Asn Val Leu Met His Ser 
            100                 105                 110         


Ser Ile Leu Ala Pro Glu Arg Glu Ser Trp Arg Thr Ala Gly Glu Gly 
        115                 120                 125             


Glu Asn Trp Arg Lys Glu Asn Leu Arg Lys Asp Met Glu Arg Asp Leu 
    130                 135                 140                 


Lys Ala Asp Ser Asn Met Pro Leu Asn Asn Ser Ser Gln Glu Val Thr 
145                 150                 155                 160 


Lys Asp Leu Leu Asp Met Ile Asp His Thr Ser Ile Arg Thr Ile Glu 
                165                 170                 175     


Glu Leu Ala Gly Lys Ile Glu Phe Glu Asn Glu Leu Asn His Met Cys 
            180                 185                 190         


Gly His Cys Gln Asp Ser Pro Phe Lys Glu Glu Ala Trp Ala Leu Leu 
        195                 200                 205             


Met Asp Lys Ser Pro Gln Lys Ala Thr Asp Ala Asp Pro Gly Ser Leu 
    210                 215                 220                 


Lys Gln Ala Phe Asp Asp His Asn Ile Val Glu Thr Val Leu Asp Leu 
225                 230                 235                 240 


Glu Glu Asp Tyr Asn Val Met Thr Ser Phe Lys Tyr Gln Ile Glu 
                245                 250                 255 


<210>  460
<211>  455
<212>  PRT
<213>  Homo sapiens

<400>  460

His Asn Gln Thr Ser Leu Tyr Lys Lys Ala Gly Thr Ser Gly Ser Cys 
1               5                   10                  15      


Cys Glu Cys Gly Cys Gly Arg Ala Ser Ser Leu Cys Ala Val Ala His 
            20                  25                  30          


Pro Ile Leu Ile Trp Arg Cys Gly Tyr Ser Lys Ala Lys Gln Asp Pro 
        35                  40                  45              


Glu Glu Glu Lys Met His Phe His Asn Gly His Ile Lys Leu Pro Gly 
    50                  55                  60                  


Val Arg Thr Tyr Ile Asp Pro His Thr Tyr Glu Asp Pro Asn Gln Ala 
65                  70                  75                  80  


Val His Glu Phe Ala Lys Glu Ile Glu Ala Ser Cys Ile Thr Ile Glu 
                85                  90                  95      


Arg Val Ile Gly Ala Gly Glu Phe Gly Glu Val Cys Ser Gly Arg Leu 
            100                 105                 110         


Lys Leu Pro Gly Lys Arg Glu Leu Pro Val Ala Ile Lys Thr Leu Lys 
        115                 120                 125             


Val Gly Tyr Thr Glu Lys Gln Arg Arg Asp Phe Leu Gly Glu Ala Ser 
    130                 135                 140                 


Ile Met Gly Gln Phe Asp His Pro Asn Ile Ile His Leu Glu Gly Val 
145                 150                 155                 160 


Val Thr Lys Ser Lys Pro Val Met Ile Val Thr Glu Tyr Met Glu Asn 
                165                 170                 175     


Gly Ser Leu Asp Thr Phe Leu Lys Lys Asn Asp Gly Gln Phe Thr Val 
            180                 185                 190         


Ile Gln Leu Val Gly Met Leu Arg Gly Ile Ser Ala Gly Met Lys Tyr 
        195                 200                 205             


Leu Ser Asp Met Gly Tyr Val His Arg Asp Leu Ala Ala Arg Asn Ile 
    210                 215                 220                 


Leu Ile Asn Ser Asn Leu Val Cys Lys Val Ser Asp Phe Gly Leu Ser 
225                 230                 235                 240 


Arg Val Leu Glu Asp Asp Pro Glu Ala Ala Tyr Thr Thr Arg Gly Gly 
                245                 250                 255     


Lys Ile Pro Ile Arg Trp Thr Ala Pro Glu Ala Ile Ala Phe Arg Lys 
            260                 265                 270         


Phe Thr Ser Ala Ser Asp Val Trp Ser Tyr Gly Ile Val Met Trp Glu 
        275                 280                 285             


Val Val Ser Tyr Gly Glu Arg Pro Tyr Trp Glu Met Thr Asn Gln Asp 
    290                 295                 300                 


Val Ile Lys Ala Val Glu Glu Gly Tyr Arg Leu Pro Ser Pro Met Asp 
305                 310                 315                 320 


Cys Pro Ala Ala Leu Tyr Gln Leu Met Leu Asp Cys Trp Gln Lys Glu 
                325                 330                 335     


Arg Asn Ser Arg Pro Lys Phe Asp Glu Ile Val Asn Met Leu Asp Lys 
            340                 345                 350         


Leu Ile Arg Asn Pro Ser Ser Leu Lys Thr Leu Val Asn Ala Ser Cys 
        355                 360                 365             


Arg Val Ser Asn Leu Leu Ala Glu His Ser Pro Leu Gly Ser Gly Ala 
    370                 375                 380                 


Tyr Arg Ser Val Gly Glu Trp Leu Glu Ala Ile Lys Met Gly Arg Tyr 
385                 390                 395                 400 


Thr Glu Ile Phe Met Glu Asn Gly Tyr Ser Ser Met Asp Ala Val Ala 
                405                 410                 415     


Gln Val Thr Leu Glu Asp Leu Arg Arg Leu Gly Val Thr Leu Val Gly 
            420                 425                 430         


His Gln Lys Lys Ile Met Asn Ser Leu Gln Glu Met Lys Val Gln Leu 
        435                 440                 445             


Val Asn Gly Met Val Pro Leu 
    450                 455 


<210>  461
<211>  171
<212>  PRT
<213>  Homo sapiens

<400>  461

Met Ser Leu Met Glu Ala Gln Ile Asp Thr Asn Val Glu His Met Ile 
1               5                   10                  15      


Val Asp Pro Pro Lys Lys Ala Leu Ala Thr Ser Met Leu Thr Gly Glu 
            20                  25                  30          


Ala Gly Ser Leu Pro Ser Thr His Met Val Val Ala Gly Met Ala Asn 
        35                  40                  45              


Ser Thr Pro Gln Gln Gln Lys Cys Arg Glu Ser Cys Ser Ser Pro Ser 
    50                  55                  60                  


Thr Val Gly Ser Ser Leu Thr Thr Arg Lys Ile Asp Pro Pro Ala Val 
65                  70                  75                  80  


Pro Ala Thr Gly Gln Phe Met Arg Ile Gln Asn Val Gly Gln Lys Lys 
                85                  90                  95      


Ala Glu Glu Ser Pro Ala Glu Ile Ile Ile Gln Ala Ile Pro Gln Tyr 
            100                 105                 110         


Ala Ile Pro Cys His Ser Ser Ser Asn Val Val Val Glu Pro Ser Gly 
        115                 120                 125             


Leu Leu Glu Leu Asn Asn Phe Thr Ser Gln Gln Leu Asp Asp Glu Glu 
    130                 135                 140                 


Thr Ala Met Glu Gln Asp Ile Asp Ser Ser Thr Glu Asp Gly Thr Glu 
145                 150                 155                 160 


Pro Ser Pro Ser Gln Ser Ser Ala Glu Arg Ser 
                165                 170     


<210>  462
<211>  51
<212>  PRT
<213>  Homo sapiens

<400>  462

Met Arg Gly Leu Pro Arg Lys Arg Glu Ala Trp Thr Arg Arg Thr Arg 
1               5                   10                  15      


Leu Pro His Pro Ser Gln Leu Met Asp His Pro Lys Arg Asn Asn Leu 
            20                  25                  30          


His Trp Asn Leu Gln Ala Lys Lys Pro Ser Leu Ala Glu Trp Lys His 
        35                  40                  45              


Phe Leu Leu 
    50      


<210>  463
<211>  525
<212>  PRT
<213>  Homo sapiens

<400>  463

Met Arg Arg Arg Arg Arg Arg Asp Gly Phe Tyr Pro Ala Pro Asp Phe 
1               5                   10                  15      


Arg Asp Arg Glu Ala Glu Asp Met Ala Gly Val Phe Asp Ile Asp Leu 
            20                  25                  30          


Asp Gln Pro Glu Asp Ala Gly Ser Glu Asp Glu Leu Glu Glu Gly Gly 
        35                  40                  45              


Gln Leu Asn Glu Ser Met Asp His Gly Gly Val Gly Pro Tyr Glu Leu 
    50                  55                  60                  


Gly Met Glu His Cys Glu Lys Phe Glu Ile Ser Glu Thr Ser Val Asn 
65                  70                  75                  80  


Arg Gly Pro Glu Lys Ile Arg Pro Glu Cys Phe Glu Leu Leu Arg Val 
                85                  90                  95      


Leu Gly Lys Gly Gly Tyr Gly Lys Val Phe Gln Val Arg Lys Val Thr 
            100                 105                 110         


Gly Ala Asn Thr Gly Lys Ile Phe Ala Met Lys Val Leu Lys Lys Ala 
        115                 120                 125             


Met Ile Val Arg Asn Ala Lys Asp Thr Ala His Thr Lys Ala Glu Arg 
    130                 135                 140                 


Asn Ile Leu Glu Glu Val Lys His Pro Phe Ile Val Asp Leu Ile Tyr 
145                 150                 155                 160 


Ala Phe Gln Thr Gly Gly Lys Leu Tyr Leu Ile Leu Glu Tyr Leu Ser 
                165                 170                 175     


Gly Gly Glu Leu Phe Met Gln Leu Glu Arg Glu Gly Ile Phe Met Glu 
            180                 185                 190         


Asp Thr Ala Cys Phe Tyr Leu Ala Glu Ile Ser Met Ala Leu Gly His 
        195                 200                 205             


Leu His Gln Lys Gly Ile Ile Tyr Arg Asp Leu Lys Pro Glu Asn Ile 
    210                 215                 220                 


Met Leu Asn His Gln Gly His Val Lys Leu Thr Asp Phe Gly Leu Cys 
225                 230                 235                 240 


Lys Glu Ser Ile His Asp Gly Thr Val Thr His Thr Phe Cys Gly Thr 
                245                 250                 255     


Ile Glu Tyr Met Ala Pro Glu Ile Leu Met Arg Ser Gly His Asn Arg 
            260                 265                 270         


Ala Val Asp Trp Trp Ser Leu Gly Ala Leu Met Tyr Asp Met Leu Thr 
        275                 280                 285             


Gly Ala Pro Pro Phe Thr Gly Glu Asn Arg Lys Lys Thr Ile Asp Lys 
    290                 295                 300                 


Ile Leu Lys Cys Lys Leu Asn Leu Pro Pro Tyr Leu Thr Gln Glu Ala 
305                 310                 315                 320 


Arg Asp Leu Leu Lys Lys Leu Leu Lys Arg Asn Ala Ala Ser Arg Leu 
                325                 330                 335     


Gly Ala Gly Pro Gly Asp Ala Gly Glu Val Gln Ala His Pro Phe Phe 
            340                 345                 350         


Arg His Ile Asn Trp Glu Glu Leu Leu Ala Arg Lys Val Glu Pro Pro 
        355                 360                 365             


Phe Lys Pro Leu Leu Gln Ser Glu Glu Asp Val Ser Gln Phe Asp Ser 
    370                 375                 380                 


Lys Phe Thr Arg Gln Thr Pro Val Asp Ser Pro Asp Asp Ser Thr Leu 
385                 390                 395                 400 


Ser Glu Ser Ala Asn Gln Val Phe Leu Gly Phe Thr Tyr Val Ala Pro 
                405                 410                 415     


Ser Val Leu Glu Ser Val Lys Glu Lys Phe Ser Phe Glu Pro Lys Ile 
            420                 425                 430         


Arg Ser Pro Arg Arg Phe Ile Gly Ser Pro Arg Thr Pro Val Ser Pro 
        435                 440                 445             


Val Lys Phe Ser Pro Gly Asp Phe Trp Gly Arg Gly Ala Ser Ala Ser 
    450                 455                 460                 


Thr Ala Asn Pro Gln Thr Pro Val Glu Tyr Pro Met Glu Thr Ser Gly 
465                 470                 475                 480 


Ile Glu Gln Met Asp Val Thr Met Ser Gly Glu Ala Ser Ala Pro Leu 
                485                 490                 495     


Pro Ile Arg Gln Pro Asn Ser Gly Pro Tyr Lys Lys Gln Ala Phe Pro 
            500                 505                 510         


Met Ile Ser Lys Arg Pro Glu His Leu Arg Met Asn Leu 
        515                 520                 525 


<210>  464
<211>  646
<212>  PRT
<213>  Homo sapiens

<400>  464

Met Ala Ala Glu Ser Gly Ser Asp Phe Gln Gln Arg Arg Arg Arg Arg 
1               5                   10                  15      


Arg Asp Pro Glu Glu Pro Glu Lys Thr Glu Leu Ser Glu Arg Glu Leu 
            20                  25                  30          


Ala Val Ala Val Ala Val Ser Gln Glu Asn Asp Glu Glu Asn Glu Glu 
        35                  40                  45              


Arg Trp Val Gly Pro Leu Pro Val Glu Ala Thr Leu Ala Lys Lys Arg 
    50                  55                  60                  


Lys Val Leu Glu Phe Glu Arg Val Tyr Leu Asp Asn Leu Pro Ser Ala 
65                  70                  75                  80  


Ser Met Tyr Glu Arg Ser Tyr Met His Arg Asp Val Ile Thr His Val 
                85                  90                  95      


Val Cys Thr Lys Thr Asp Phe Ile Ile Thr Ala Ser His Asp Gly His 
            100                 105                 110         


Val Lys Phe Trp Lys Lys Ile Glu Glu Gly Ile Glu Phe Val Lys His 
        115                 120                 125             


Phe Arg Ser His Leu Gly Val Ile Glu Ser Ile Ala Val Ser Ser Glu 
    130                 135                 140                 


Gly Ala Leu Phe Cys Ser Val Gly Asp Asp Lys Ala Met Lys Val Phe 
145                 150                 155                 160 


Asp Val Val Asn Phe Asp Met Ile Asn Met Leu Lys Leu Gly Tyr Phe 
                165                 170                 175     


Pro Gly Gln Cys Glu Trp Ile Tyr Cys Pro Gly Asp Ala Ile Ser Ser 
            180                 185                 190         


Val Ala Ala Ser Glu Lys Ser Thr Gly Lys Ile Phe Ile Tyr Asp Gly 
        195                 200                 205             


Arg Gly Asp Asn Gln Pro Leu His Ile Phe Asp Lys Leu His Thr Ser 
    210                 215                 220                 


Pro Leu Thr Gln Ile Arg Leu Asn Pro Val Tyr Lys Ala Val Val Ser 
225                 230                 235                 240 


Ser Asp Lys Ser Gly Met Ile Glu Tyr Trp Thr Gly Pro Pro His Glu 
                245                 250                 255     


Tyr Lys Phe Pro Lys Asn Val Asn Trp Glu Tyr Lys Thr Asp Thr Asp 
            260                 265                 270         


Leu Tyr Glu Phe Ala Lys Cys Lys Ala Tyr Pro Thr Ser Val Cys Phe 
        275                 280                 285             


Ser Pro Asp Gly Lys Lys Ile Ala Thr Ile Gly Ser Asp Arg Lys Val 
    290                 295                 300                 


Arg Ile Phe Arg Phe Val Thr Gly Lys Leu Met Arg Val Phe Asp Glu 
305                 310                 315                 320 


Ser Leu Ser Met Phe Thr Glu Leu Gln Gln Met Arg Gln Gln Leu Pro 
                325                 330                 335     


Asp Met Glu Phe Gly Arg Arg Met Ala Val Glu Arg Glu Leu Glu Lys 
            340                 345                 350         


Val Asp Ala Val Arg Leu Ile Asn Ile Val Phe Asp Glu Thr Gly His 
        355                 360                 365             


Phe Val Leu Tyr Gly Thr Met Leu Gly Ile Lys Val Ile Asn Val Glu 
    370                 375                 380                 


Thr Asn Arg Cys Val Arg Ile Leu Gly Lys Gln Glu Asn Ile Arg Val 
385                 390                 395                 400 


Met Gln Leu Ala Leu Phe Gln Gly Ile Ala Lys Lys His Arg Ala Ala 
                405                 410                 415     


Thr Thr Ile Glu Met Lys Ala Ser Glu Asn Pro Val Leu Gln Asn Ile 
            420                 425                 430         


Gln Ala Asp Pro Thr Ile Val Cys Thr Ser Phe Lys Lys Asn Arg Phe 
        435                 440                 445             


Tyr Met Phe Thr Lys Arg Glu Pro Glu Asp Thr Lys Ser Ala Asp Ser 
    450                 455                 460                 


Asp Arg Asp Val Phe Asn Glu Lys Pro Ser Lys Glu Glu Val Met Ala 
465                 470                 475                 480 


Ala Thr Gln Ala Glu Gly Pro Lys Arg Val Ser Asp Ser Ala Ile Ile 
                485                 490                 495     


His Thr Ser Met Gly Asp Ile His Thr Lys Leu Phe Pro Val Glu Cys 
            500                 505                 510         


Pro Lys Thr Val Glu Asn Phe Cys Val His Ser Arg Asn Gly Tyr Tyr 
        515                 520                 525             


Asn Gly His Thr Phe His Arg Ile Ile Lys Gly Phe Met Ile Gln Thr 
    530                 535                 540                 


Gly Asp Pro Thr Gly Thr Gly Met Gly Gly Glu Ser Ile Trp Gly Gly 
545                 550                 555                 560 


Glu Phe Glu Asp Glu Phe His Ser Thr Leu Arg His Asp Arg Pro Tyr 
                565                 570                 575     


Thr Leu Ser Met Ala Asn Ala Gly Ser Asn Thr Asn Gly Ser Gln Phe 
            580                 585                 590         


Phe Ile Thr Val Val Pro Thr Pro Trp Leu Asp Asn Lys His Thr Val 
        595                 600                 605             


Phe Gly Arg Val Thr Lys Gly Met Glu Val Val Gln Arg Ile Ser Asn 
    610                 615                 620                 


Val Lys Val Asn Pro Lys Thr Asp Lys Pro Tyr Glu Asp Val Ser Ile 
625                 630                 635                 640 


Ile Asn Ile Thr Val Lys 
                645     


<210>  465
<211>  307
<212>  PRT
<213>  Homo sapiens

<400>  465

Met Ser Lys Arg Lys Leu Ile Pro Lys Leu Ser Ile Gln Ser Pro Val 
1               5                   10                  15      


Leu His Thr Asn Leu Asn Val Gln Ser Thr His Pro Pro Leu Lys Lys 
            20                  25                  30          


Glu Asp Leu His Arg Ile Ser Lys Asp Ser Leu Glu Ser Asp Ser Glu 
        35                  40                  45              


Ser Leu Thr Gln Glu Ile Met Cys His Ser Glu Phe Asp Asp Arg Ile 
    50                  55                  60                  


Arg Gly Asn Gly Met Glu Pro Asp Ser Leu Asp Glu Glu Glu Ser Pro 
65                  70                  75                  80  


Arg Trp Gly Ser Leu His Glu Met Glu Glu Glu Ala Ser Gly Lys Ala 
                85                  90                  95      


Ala Gln Met Ala Arg Glu Gln Asn His His Thr Trp Asp Gln Gly Ala 
            100                 105                 110         


Asn Asn Arg Gln Gln Pro Ile Glu Asp Lys Tyr Ser Asp Leu Arg Tyr 
        115                 120                 125             


Asp Pro Asn Trp Lys Ser Lys Lys Glu Glu Gly Gln Leu Leu Ser Val 
    130                 135                 140                 


Glu Ala Leu Pro Glu Ser Thr Asp Ser Ser Leu Glu Asn Leu Pro Leu 
145                 150                 155                 160 


Ala Pro Leu Tyr Pro Ser Gln Glu Thr Ser Met Glu Leu Ser Gly Gly 
                165                 170                 175     


Lys Gly Glu Gln Lys Glu Ser Pro Gln Ser Ala Ala Ser Leu Leu Gly 
            180                 185                 190         


Ser Glu Phe Leu Ser Pro Asn Tyr Glu His Gly Ala Arg Arg Ser Lys 
        195                 200                 205             


Pro Phe Ser Glu Leu Ser Asp Ser Asp Leu Glu Glu Lys Ser Ser Ser 
    210                 215                 220                 


Leu Ser Pro Tyr Val Lys Ser Ser Ser Ser His Asn Glu Val Phe Leu 
225                 230                 235                 240 


Pro Gly Ser Arg Gly Pro Arg Arg Arg Lys Ser Lys Gln His Phe Val 
                245                 250                 255     


Glu Lys Asn Lys Leu Thr Leu Gly Leu Pro Thr Pro Lys Thr Asp Ser 
            260                 265                 270         


Tyr Leu Gln Leu His Asn Lys Lys Arg Gly Glu Ser His Pro Glu Gln 
        275                 280                 285             


Val Ile Leu Arg Val Asn Ser Leu Pro Arg Asp Gly Phe Lys Thr Phe 
    290                 295                 300                 


Trp Ser Gln 
305         


<210>  466
<211>  280
<212>  PRT
<213>  Homo sapiens

<400>  466

Met Arg Arg Ala Glu Leu Ala Gly Leu Lys Thr Met Ala Trp Val Pro 
1               5                   10                  15      


Ala Glu Ser Ala Val Glu Glu Leu Met Pro Arg Leu Leu Pro Val Glu 
            20                  25                  30          


Pro Cys Asp Leu Thr Glu Gly Phe Asp Pro Ser Val Pro Pro Arg Thr 
        35                  40                  45              


Pro Gln Glu Tyr Leu Arg Arg Val Gln Ile Glu Ala Ala Gln Cys Pro 
    50                  55                  60                  


Asp Val Val Val Ala Gln Ile Asp Pro Lys Lys Leu Lys Arg Lys Gln 
65                  70                  75                  80  


Ser Val Asn Ile Ser Leu Ser Gly Cys Gln Pro Ala Pro Glu Gly Tyr 
                85                  90                  95      


Ser Pro Thr Leu Gln Trp Gln Gln Gln Gln Val Ala Gln Phe Ser Thr 
            100                 105                 110         


Val Arg Gln Asn Val Asn Lys His Arg Ser His Trp Lys Ser Gln Gln 
        115                 120                 125             


Leu Asp Ser Asn Val Thr Met Pro Lys Ser Glu Asp Glu Glu Gly Trp 
    130                 135                 140                 


Lys Lys Phe Cys Leu Gly Glu Lys Leu Cys Ala Asp Gly Ala Val Gly 
145                 150                 155                 160 


Pro Ala Thr Asn Glu Ser Pro Gly Ile Asp Tyr Val Gln Ile Gly Phe 
                165                 170                 175     


Pro Pro Leu Leu Ser Ile Val Ser Arg Met Asn Gln Ala Thr Val Thr 
            180                 185                 190         


Ser Val Leu Glu Tyr Leu Ser Asn Trp Phe Gly Glu Arg Asp Phe Thr 
        195                 200                 205             


Pro Glu Leu Gly Arg Trp Leu Tyr Ala Leu Leu Ala Cys Leu Glu Lys 
    210                 215                 220                 


Pro Leu Leu Pro Glu Ala His Ser Leu Ile Arg Gln Leu Ala Arg Arg 
225                 230                 235                 240 


Cys Ser Glu Val Arg Leu Leu Val Asp Ser Lys Asp Asp Glu Arg Val 
                245                 250                 255     


Pro Ala Leu Asn Leu Leu Ile Cys Leu Val Ser Arg Tyr Phe Asp Gln 
            260                 265                 270         


Arg Asp Leu Ala Asp Glu Pro Ser 
        275                 280 


<210>  467
<211>  756
<212>  PRT
<213>  Homo sapiens

<400>  467

Met Gly Lys Arg Gly Ser Arg Ser Gln Ser Gln Leu Leu Asn Thr Leu 
1               5                   10                  15      


Thr Lys Lys Gln Lys Lys His Leu Arg Asp Phe Gly Glu Glu His Pro 
            20                  25                  30          


Phe Tyr Asp Arg Val Ser Arg Lys Glu Ala Lys Pro Gln Ile Cys Gln 
        35                  40                  45              


Leu Ser Glu Ser Ser Asp Ser Ser Asp Ser Glu Ser Asp Ser Glu Ser 
    50                  55                  60                  


Glu Pro Gln Gln Val Ser Gly Tyr His Arg Leu Leu Ala Thr Leu Lys 
65                  70                  75                  80  


Asn Val Ser Glu Glu Glu Glu Glu Asp Glu Glu Glu Glu Glu Glu Glu 
                85                  90                  95      


Asp Ser Ile Val Asp Asp Ala Glu Met Asn Asp Glu Asp Gly Gly Ser 
            100                 105                 110         


Asp Val Ser Val Glu Glu Glu Met Ala Ala Glu Ser Thr Glu Ser Pro 
        115                 120                 125             


Glu Asn Val Ala Leu Ser Ala Asp Pro Glu Gly Lys Glu Asp Gly Glu 
    130                 135                 140                 


Glu Pro Pro Gly Thr Ser Gln Thr Ser Pro Glu Glu Phe Thr Asp Ala 
145                 150                 155                 160 


Lys His Glu Ser Leu Phe Ser Leu Glu Thr Asn Phe Leu Glu Glu Glu 
                165                 170                 175     


Ser Gly Asp Asn Ser Ser Leu Lys Ala Ser Gln Asp Pro Phe Leu Gln 
            180                 185                 190         


His Val Asn Lys Glu Leu Lys Glu Lys Ala Ile Gln Ala Val Ala Thr 
        195                 200                 205             


Asn Pro Lys Thr Thr His Glu Leu Lys Trp Pro Ile Leu Gly Gln Leu 
    210                 215                 220                 


Phe Phe Ser Ser Lys Phe Gln Lys Leu Glu Thr Phe Lys Pro Pro Lys 
225                 230                 235                 240 


Asp Ile Asp Leu Lys Ser Leu His Leu Gln Lys Pro Leu Glu Ser Thr 
                245                 250                 255     


Trp Thr Lys Thr Asn Ser Gln Phe Leu Ser Gly Pro Gln Lys Ser Ser 
            260                 265                 270         


Ser Pro Phe Thr Pro Leu Gln Lys Glu Leu Phe Leu Ile Met Asn Ser 
        275                 280                 285             


Tyr Arg Asp Leu Phe Tyr Pro Glu Arg Thr Ala Leu Lys Asn Gly Glu 
    290                 295                 300                 


Glu Ile Arg His Val Tyr Cys Leu His Val Ile Asn His Ile Leu Lys 
305                 310                 315                 320 


Ala Asn Ala Gln Val Leu Gly Asn Asn Ser Arg Arg Arg Ser Gln Lys 
                325                 330                 335     


Phe Gly Val Gly Asp Asp Asp Asp Phe Arg Asp Gln Gly Leu Thr Arg 
            340                 345                 350         


Pro Lys Val Leu Ile Val Val Pro Phe Arg Glu Ala Ala Leu Arg Val 
        355                 360                 365             


Val Gln Leu Phe Ile Ser Leu Leu Glu Gly Asp Ser Lys Lys Lys Ile 
    370                 375                 380                 


Ile Val Ser Asn Lys Lys Arg Phe Gln Gly Glu Tyr Gly Ser Asp Pro 
385                 390                 395                 400 


Glu Glu Arg Pro Pro Asn Leu Lys Arg Pro Glu Asp Tyr Glu Ala Val 
                405                 410                 415     


Phe Val Gly Asn Ile Asp Asp His Phe Arg Ile Gly Val Ala Ile Leu 
            420                 425                 430         


Gln Arg Ser Ile Arg Leu Tyr Ala Pro Phe Tyr Ser Ser Asp Ile Leu 
        435                 440                 445             


Ile Ala Ser Pro Leu Gly Leu Arg Thr Ile Ile Gly Gly Glu Gly Glu 
    450                 455                 460                 


Lys Lys Arg Asp Phe Asp Phe Leu Ser Ser Ile Glu Leu Leu Ile Ile 
465                 470                 475                 480 


Asp Gln Ala Asp Ile Tyr Leu Met Gln Asn Trp Glu His Val Leu His 
                485                 490                 495     


Leu Met Asn His Met Asn Leu Leu Pro Leu Asp Ser His Gly Val Asp 
            500                 505                 510         


Phe Ser Arg Val Arg Met Trp Ser Leu Asn Asn Trp Ser Lys Tyr Tyr 
        515                 520                 525             


Arg Gln Thr Leu Leu Phe Gly Ala Leu Gln Asp Ala Gln Ile Asn Ser 
    530                 535                 540                 


Val Phe Asn Lys Tyr Cys Val Asn Met Gln Gly Gln Val Ala Val Arg 
545                 550                 555                 560 


Asn Val Pro Met Thr Gly Ser Ile Ser His Val Leu Val Gln Leu Pro 
                565                 570                 575     


His Val Phe Gln Arg Met Glu Ala Glu Asn Leu Ala Ser Val Ile Asp 
            580                 585                 590         


Ala Arg Phe Asn Phe Phe Val Asn Lys Ile Leu Pro Gln Tyr Arg Asp 
        595                 600                 605             


Ala Val Met Ser His Thr Leu Ile Tyr Ile Pro Ser Tyr Phe Asp Phe 
    610                 615                 620                 


Val Arg Leu Arg Asn Tyr Phe Lys Lys Glu Glu Leu Asn Phe Thr His 
625                 630                 635                 640 


Ile Cys Glu Tyr Thr Gln Lys Ser Gly Val Ser Arg Ala Arg His Phe 
                645                 650                 655     


Phe Leu Gln Gly Glu Lys Gln Phe Leu Leu Phe Thr Glu Arg Phe His 
            660                 665                 670         


Phe Tyr Lys Arg Tyr Thr Ile Lys Gly Ile Arg Asn Leu Ile Phe Tyr 
        675                 680                 685             


Glu Leu Pro Thr Tyr Pro His Phe Tyr Ser Glu Ile Cys Asn Met Leu 
    690                 695                 700                 


Arg Ala Thr Asn Arg Gly Glu Glu Ala Thr Trp Thr Cys Thr Val Leu 
705                 710                 715                 720 


Tyr Ser Lys Tyr Asp Ala Gln Arg Leu Ala Ala Val Val Gly Val Glu 
                725                 730                 735     


Arg Ala Ala Gln Met Leu Gln Ser Asn Lys Asn Val His Leu Phe Ile 
            740                 745                 750         


Thr Gly Glu Lys 
        755     


<210>  468
<211>  711
<212>  PRT
<213>  Homo sapiens

<400>  468

Met Lys Leu Lys Leu Asn Val Leu Thr Ile Ile Leu Leu Pro Val His 
1               5                   10                  15      


Leu Leu Ile Thr Ile Tyr Ser Ala Leu Ile Phe Ile Pro Trp Tyr Phe 
            20                  25                  30          


Leu Thr Asn Ala Lys Lys Lys Asn Ala Met Ala Lys Arg Ile Lys Ala 
        35                  40                  45              


Lys Pro Thr Ser Asp Lys Pro Gly Ser Pro Tyr Arg Ser Val Thr His 
    50                  55                  60                  


Phe Asp Ser Leu Ala Val Ile Asp Ile Pro Gly Ala Asp Thr Leu Asp 
65                  70                  75                  80  


Lys Leu Phe Asp His Ala Val Ser Lys Phe Gly Lys Lys Asp Ser Leu 
                85                  90                  95      


Gly Thr Arg Glu Ile Leu Ser Glu Glu Asn Glu Met Gln Pro Asn Gly 
            100                 105                 110         


Lys Val Phe Lys Lys Leu Ile Leu Gly Asn Tyr Lys Trp Met Asn Tyr 
        115                 120                 125             


Leu Glu Val Asn Arg Arg Val Asn Asn Phe Gly Ser Gly Leu Thr Ala 
    130                 135                 140                 


Leu Gly Leu Lys Pro Lys Asn Thr Ile Ala Ile Phe Cys Glu Thr Arg 
145                 150                 155                 160 


Ala Glu Trp Met Ile Ala Ala Gln Thr Cys Phe Lys Tyr Asn Phe Pro 
                165                 170                 175     


Leu Val Thr Leu Tyr Ala Thr Leu Gly Lys Glu Ala Val Val His Gly 
            180                 185                 190         


Leu Asn Glu Ser Glu Ala Ser Tyr Leu Ile Thr Ser Val Glu Leu Leu 
        195                 200                 205             


Glu Ser Lys Leu Lys Thr Ala Leu Leu Asp Ile Ser Cys Val Lys His 
    210                 215                 220                 


Ile Ile Tyr Val Asp Asn Lys Ala Ile Asn Lys Ala Glu Tyr Pro Glu 
225                 230                 235                 240 


Gly Phe Glu Ile His Ser Met Gln Ser Val Glu Glu Leu Gly Ser Asn 
                245                 250                 255     


Pro Glu Asn Leu Gly Ile Pro Pro Ser Arg Pro Thr Pro Ser Asp Met 
            260                 265                 270         


Ala Ile Val Met Tyr Thr Ser Gly Ser Thr Gly Arg Pro Lys Gly Val 
        275                 280                 285             


Met Met His His Ser Asn Leu Ile Ala Gly Met Thr Gly Gln Cys Glu 
    290                 295                 300                 


Arg Ile Pro Gly Leu Gly Pro Lys Asp Thr Tyr Ile Gly Tyr Leu Pro 
305                 310                 315                 320 


Leu Ala His Val Leu Glu Leu Thr Ala Glu Ile Ser Cys Phe Thr Tyr 
                325                 330                 335     


Gly Cys Arg Ile Gly Tyr Ser Ser Pro Leu Thr Leu Ser Asp Gln Ser 
            340                 345                 350         


Ser Lys Ile Lys Lys Gly Ser Lys Gly Asp Cys Thr Val Leu Lys Pro 
        355                 360                 365             


Thr Leu Met Ala Ala Val Pro Glu Ile Met Asp Arg Ile Tyr Lys Asn 
    370                 375                 380                 


Val Met Ser Lys Val Gln Glu Met Asn Tyr Ile Gln Lys Thr Leu Phe 
385                 390                 395                 400 


Lys Ile Gly Tyr Asp Tyr Lys Leu Glu Gln Ile Lys Lys Gly Tyr Asp 
                405                 410                 415     


Ala Pro Leu Cys Asn Leu Leu Leu Phe Lys Lys Val Lys Ala Leu Leu 
            420                 425                 430         


Gly Gly Asn Val Arg Met Met Leu Ser Gly Gly Ala Pro Leu Ser Pro 
        435                 440                 445             


Gln Thr His Arg Phe Met Asn Val Cys Phe Cys Cys Pro Ile Gly Gln 
    450                 455                 460                 


Gly Tyr Gly Leu Thr Glu Ser Cys Gly Ala Gly Thr Val Thr Glu Val 
465                 470                 475                 480 


Thr Asp Tyr Thr Thr Gly Arg Val Gly Ala Pro Leu Ile Cys Cys Glu 
                485                 490                 495     


Ile Lys Leu Lys Asp Trp Gln Glu Gly Gly Tyr Thr Ile Asn Asp Lys 
            500                 505                 510         


Pro Asn Pro Arg Gly Glu Ile Val Ile Gly Gly Gln Asn Ile Ser Met 
        515                 520                 525             


Gly Tyr Phe Lys Asn Glu Glu Lys Thr Ala Glu Asp Tyr Ser Val Asp 
    530                 535                 540                 


Glu Asn Gly Gln Arg Trp Phe Cys Thr Gly Asp Ile Gly Glu Phe His 
545                 550                 555                 560 


Pro Asp Gly Cys Leu Gln Ile Ile Asp Arg Lys Lys Asp Leu Val Lys 
                565                 570                 575     


Leu Gln Ala Gly Glu Tyr Val Ser Leu Gly Lys Val Glu Ala Ala Leu 
            580                 585                 590         


Lys Asn Cys Pro Leu Ile Asp Asn Ile Cys Ala Phe Ala Lys Ser Asp 
        595                 600                 605             


Gln Ser Tyr Val Ile Ser Phe Val Val Pro Asn Gln Lys Arg Leu Thr 
    610                 615                 620                 


Leu Leu Ala Gln Gln Lys Gly Val Glu Gly Thr Trp Val Asp Ile Cys 
625                 630                 635                 640 


Asn Asn Pro Ala Met Glu Ala Glu Ile Leu Lys Glu Ile Arg Glu Ala 
                645                 650                 655     


Ala Asn Ala Met Lys Leu Glu Arg Phe Glu Ile Pro Ile Lys Val Arg 
            660                 665                 670         


Leu Ser Pro Glu Pro Trp Thr Pro Glu Thr Gly Leu Val Thr Asp Ala 
        675                 680                 685             


Phe Lys Leu Lys Arg Lys Glu Leu Arg Asn His Tyr Leu Lys Asp Ile 
    690                 695                 700                 


Glu Arg Met Tyr Gly Gly Lys 
705                 710     


<210>  469
<211>  360
<212>  PRT
<213>  Homo sapiens

<400>  469

Met Glu Leu Asp Phe Gly His Phe Asp Glu Arg Asp Lys Thr Ser Arg 
1               5                   10                  15      


Asn Met Arg Gly Ser Arg Met Asn Gly Leu Pro Ser Pro Thr His Ser 
            20                  25                  30          


Ala His Cys Ser Phe Tyr Arg Thr Arg Thr Leu Gln Ala Leu Ser Asn 
        35                  40                  45              


Glu Lys Lys Ala Lys Lys Val Arg Phe Tyr Arg Asn Gly Asp Arg Tyr 
    50                  55                  60                  


Phe Lys Gly Ile Val Tyr Ala Val Ser Ser Asp Arg Phe Arg Ser Phe 
65                  70                  75                  80  


Asp Ala Leu Leu Ala Asp Leu Thr Arg Ser Leu Ser Asp Asn Ile Asn 
                85                  90                  95      


Leu Pro Gln Gly Val Arg Tyr Ile Tyr Thr Ile Asp Gly Ser Arg Lys 
            100                 105                 110         


Ile Gly Ser Met Asp Glu Leu Glu Glu Gly Glu Ser Tyr Val Cys Ser 
        115                 120                 125             


Ser Asp Asn Phe Phe Lys Lys Val Glu Tyr Thr Lys Asn Val Asn Pro 
    130                 135                 140                 


Asn Trp Ser Val Asn Val Lys Thr Ser Ala Asn Met Lys Ala Pro Gln 
145                 150                 155                 160 


Ser Leu Ala Ser Ser Asn Ser Ala Gln Ala Arg Glu Asn Lys Asp Phe 
                165                 170                 175     


Val Arg Pro Lys Leu Val Thr Ile Ile Arg Ser Gly Val Lys Pro Arg 
            180                 185                 190         


Lys Ala Val Arg Val Leu Leu Asn Lys Lys Thr Ala His Ser Phe Glu 
        195                 200                 205             


Gln Val Leu Thr Asp Ile Thr Glu Ala Ile Lys Leu Glu Thr Gly Val 
    210                 215                 220                 


Val Lys Lys Leu Tyr Thr Leu Asp Gly Lys Gln Val Thr Cys Leu His 
225                 230                 235                 240 


Asp Phe Phe Gly Asp Asp Asp Val Phe Ile Ala Cys Gly Pro Glu Lys 
                245                 250                 255     


Phe Arg Tyr Ala Gln Asp Asp Phe Ser Leu Asp Glu Asn Glu Cys Arg 
            260                 265                 270         


Val Met Lys Gly Asn Pro Ser Ala Thr Ala Gly Pro Lys Ala Ser Pro 
        275                 280                 285             


Thr Pro Gln Lys Thr Ser Ala Lys Ser Pro Gly Pro Met Arg Arg Ser 
    290                 295                 300                 


Lys Ser Pro Ala Asp Ser Ala Asn Gly Thr Ser Ser Ser Gln Leu Ser 
305                 310                 315                 320 


Thr Pro Lys Ser Lys Gln Ser Pro Ile Ser Thr Pro Thr Ser Pro Gly 
                325                 330                 335     


Ser Leu Arg Lys His Lys Asp Leu Tyr Leu Pro Leu Ser Leu Asp Asp 
            340                 345                 350         


Ser Asp Ser Leu Gly Asp Ser Met 
        355                 360 


<210>  470
<211>  324
<212>  PRT
<213>  Homo sapiens

<400>  470

Met Gly Ala Phe Leu Asp Lys Pro Lys Met Glu Lys His Asn Ala Gln 
1               5                   10                  15      


Gly Gln Gly Asn Gly Leu Arg Tyr Gly Leu Ser Ser Met Gln Gly Trp 
            20                  25                  30          


Arg Val Glu Met Glu Asp Ala His Thr Ala Val Ile Gly Leu Pro Ser 
        35                  40                  45              


Gly Leu Glu Ser Trp Ser Phe Phe Ala Val Tyr Asp Gly His Ala Gly 
    50                  55                  60                  


Ser Gln Val Ala Lys Tyr Cys Cys Glu His Leu Leu Asp His Ile Thr 
65                  70                  75                  80  


Asn Asn Gln Asp Phe Lys Gly Ser Ala Gly Ala Pro Ser Val Glu Asn 
                85                  90                  95      


Val Lys Asn Gly Ile Arg Thr Gly Phe Leu Glu Ile Asp Glu His Met 
            100                 105                 110         


Arg Val Met Ser Glu Lys Lys His Gly Ala Asp Arg Ser Gly Ser Thr 
        115                 120                 125             


Ala Val Gly Val Leu Ile Ser Pro Gln His Thr Tyr Phe Ile Asn Cys 
    130                 135                 140                 


Gly Asp Ser Arg Gly Leu Leu Cys Arg Asn Arg Lys Val His Phe Phe 
145                 150                 155                 160 


Thr Gln Asp His Lys Pro Ser Asn Pro Leu Glu Lys Glu Arg Ile Gln 
                165                 170                 175     


Asn Ala Gly Gly Ser Val Met Ile Gln Arg Val Asn Gly Ser Leu Ala 
            180                 185                 190         


Val Ser Arg Ala Leu Gly Asp Phe Asp Tyr Lys Cys Val His Gly Lys 
        195                 200                 205             


Gly Pro Thr Glu Gln Leu Val Ser Pro Glu Pro Glu Val His Asp Ile 
    210                 215                 220                 


Glu Arg Ser Glu Glu Asp Asp Gln Phe Ile Ile Leu Ala Cys Asp Gly 
225                 230                 235                 240 


Ile Trp Asp Val Met Gly Asn Glu Glu Leu Cys Asp Phe Val Arg Ser 
                245                 250                 255     


Arg Leu Glu Val Thr Asp Asp Leu Glu Lys Val Cys Asn Glu Val Val 
            260                 265                 270         


Asp Thr Cys Leu Tyr Lys Gly Ser Arg Asp Asn Met Ser Val Ile Leu 
        275                 280                 285             


Ile Cys Phe Pro Asn Ala Pro Lys Val Ser Pro Glu Ala Val Lys Lys 
    290                 295                 300                 


Glu Ala Glu Leu Asp Lys Tyr Leu Glu Cys Arg Val Glu Gly Gly Ser 
305                 310                 315                 320 


Phe Asn Lys Lys 
                


<210>  471
<211>  399
<212>  PRT
<213>  Homo sapiens

<400>  471

Met Gly Ala Ser Phe Trp Pro Ile Arg Gln Ala Arg Glu Gln Gln Arg 
1               5                   10                  15      


Arg Ala Leu Ser Phe Arg Gln Thr Ser Trp Leu Ser Glu Pro Pro Leu 
            20                  25                  30          


Gly Pro Ala Pro His Leu Ser Met Val Gln Ala His Gly Gly Arg Ser 
        35                  40                  45              


Arg Ala Gln Pro Leu Thr Leu Ser Leu Gly Ala Ala Met Thr Gln Pro 
    50                  55                  60                  


Pro Pro Glu Lys Thr Pro Ala Lys Lys His Val Arg Leu Gln Glu Arg 
65                  70                  75                  80  


Arg Gly Ser Asn Val Ala Leu Met Leu Asp Val Arg Ser Leu Gly Ala 
                85                  90                  95      


Val Glu Pro Ile Cys Ser Val Asn Thr Pro Arg Glu Val Thr Leu His 
            100                 105                 110         


Phe Leu Arg Thr Ala Gly His Pro Leu Thr Arg Trp Ala Leu Gln Arg 
        115                 120                 125             


Gln Pro Pro Ser Pro Lys Gln Leu Glu Glu Glu Phe Leu Lys Ile Pro 
    130                 135                 140                 


Ser Asn Phe Val Ser Pro Glu Asp Leu Asp Ile Pro Gly His Ala Ser 
145                 150                 155                 160 


Lys Asp Arg Tyr Lys Thr Ile Leu Pro Asn Pro Gln Ser Arg Val Cys 
                165                 170                 175     


Leu Gly Arg Ala Gln Ser Gln Glu Asp Gly Asp Tyr Ile Asn Ala Asn 
            180                 185                 190         


Tyr Ile Arg Gly Tyr Asp Gly Lys Glu Lys Val Tyr Ile Ala Thr Gln 
        195                 200                 205             


Gly Pro Met Pro Asn Thr Val Ser Asp Phe Trp Glu Met Val Trp Gln 
    210                 215                 220                 


Glu Glu Val Ser Leu Ile Val Met Leu Thr Gln Leu Arg Glu Gly Lys 
225                 230                 235                 240 


Glu Lys Cys Val His Tyr Trp Pro Thr Glu Glu Glu Thr Tyr Gly Pro 
                245                 250                 255     


Phe Gln Ile Arg Ile Gln Asp Met Lys Glu Cys Pro Glu Tyr Thr Val 
            260                 265                 270         


Arg Gln Leu Thr Ile Gln Tyr Gln Glu Glu Arg Arg Ser Val Lys His 
        275                 280                 285             


Ile Leu Phe Ser Ala Trp Pro Asp His Gln Thr Pro Glu Ser Ala Gly 
    290                 295                 300                 


Pro Leu Leu Arg Leu Val Ala Glu Val Glu Glu Ser Pro Glu Thr Ala 
305                 310                 315                 320 


Ala His Pro Gly Pro Ile Val Val His Cys Ser Ala Gly Ile Gly Arg 
                325                 330                 335     


Thr Gly Cys Phe Ile Ala Thr Arg Ile Gly Cys Gln Gln Leu Lys Ala 
            340                 345                 350         


Arg Gly Glu Val Asp Ile Leu Gly Ile Val Cys Gln Leu Arg Leu Asp 
        355                 360                 365             


Arg Gly Gly Met Ile Gln Thr Ala Glu Gln Tyr Gln Phe Leu His His 
    370                 375                 380                 


Thr Leu Ala Leu Tyr Ala Gly Gln Leu Pro Glu Glu Pro Ser Pro 
385                 390                 395                 


<210>  472
<211>  109
<212>  PRT
<213>  Homo sapiens

<400>  472

Met Ala Val Val Gly Val Ser Ser Val Ser Arg Leu Leu Gly Arg Ser 
1               5                   10                  15      


Arg Pro Gln Leu Gly Arg Pro Met Ser Ser Gly Ala His Gly Glu Glu 
            20                  25                  30          


Gly Ser Ala Arg Met Trp Lys Thr Leu Thr Phe Phe Val Ala Leu Pro 
        35                  40                  45              


Gly Val Ala Val Ser Met Leu Asn Val Tyr Leu Lys Ser His His Gly 
    50                  55                  60                  


Glu His Glu Arg Pro Glu Phe Ile Ala Tyr Pro His Leu Arg Ile Arg 
65                  70                  75                  80  


Thr Lys Pro Phe Pro Trp Gly Asp Gly Asn His Thr Leu Phe His Asn 
                85                  90                  95      


Pro His Val Asn Pro Leu Pro Thr Gly Tyr Glu Asp Glu 
            100                 105                 


<210>  473
<211>  322
<212>  PRT
<213>  Homo sapiens

<400>  473

Met Glu Gly Ile Ser Asn Phe Lys Thr Pro Ser Lys Leu Ser Glu Lys 
1               5                   10                  15      


Lys Lys Ser Val Leu Cys Ser Thr Pro Thr Ile Asn Ile Pro Ala Ser 
            20                  25                  30          


Pro Phe Met Gln Lys Leu Gly Phe Gly Thr Gly Val Asn Val Tyr Leu 
        35                  40                  45              


Met Lys Arg Ser Pro Arg Gly Leu Ser His Ser Pro Trp Ala Val Lys 
    50                  55                  60                  


Lys Ile Asn Pro Ile Cys Asn Asp His Tyr Arg Ser Val Tyr Gln Lys 
65                  70                  75                  80  


Arg Leu Met Asp Glu Ala Lys Ile Leu Lys Ser Leu His His Pro Asn 
                85                  90                  95      


Ile Val Gly Tyr Arg Ala Phe Thr Glu Ala Asn Asp Gly Ser Leu Cys 
            100                 105                 110         


Leu Ala Met Glu Tyr Gly Gly Glu Lys Ser Leu Asn Asp Leu Ile Glu 
        115                 120                 125             


Glu Arg Tyr Lys Ala Ser Gln Asp Pro Phe Pro Ala Ala Ile Ile Leu 
    130                 135                 140                 


Lys Val Ala Leu Asn Met Ala Arg Gly Leu Lys Tyr Leu His Gln Glu 
145                 150                 155                 160 


Lys Lys Leu Leu His Gly Asp Ile Lys Ser Ser Asn Val Val Ile Lys 
                165                 170                 175     


Gly Asp Phe Glu Thr Ile Lys Ile Cys Asp Val Gly Val Ser Leu Pro 
            180                 185                 190         


Leu Asp Glu Asn Met Thr Val Thr Asp Pro Glu Ala Cys Tyr Ile Gly 
        195                 200                 205             


Thr Glu Pro Trp Lys Pro Lys Glu Ala Val Glu Glu Asn Gly Val Ile 
    210                 215                 220                 


Thr Asp Lys Ala Asp Ile Phe Ala Phe Gly Leu Thr Leu Trp Glu Met 
225                 230                 235                 240 


Met Thr Leu Ser Ile Pro His Ile Asn Leu Ser Asn Asp Asp Asp Asp 
                245                 250                 255     


Glu Asp Lys Thr Phe Asp Glu Ser Asp Phe Asp Asp Glu Ala Tyr Tyr 
            260                 265                 270         


Ala Ala Leu Gly Thr Arg Pro Pro Ile Asn Met Glu Glu Leu Asp Glu 
        275                 280                 285             


Ser Tyr Gln Lys Val Ile Glu Leu Phe Ser Val Cys Thr Asn Glu Asp 
    290                 295                 300                 


Pro Lys Asp Arg Pro Ser Ala Ala His Ile Val Glu Ala Leu Glu Thr 
305                 310                 315                 320 


Asp Val 
        


<210>  474
<211>  276
<212>  PRT
<213>  Homo sapiens

<400>  474

Met Ala Ala Gly Phe Lys Thr Val Glu Pro Leu Glu Tyr Tyr Arg Arg 
1               5                   10                  15      


Phe Leu Lys Glu Asn Cys Arg Pro Asp Gly Arg Glu Leu Gly Glu Phe 
            20                  25                  30          


Arg Thr Thr Thr Val Asn Ile Gly Ser Ile Ser Thr Ala Asp Gly Ser 
        35                  40                  45              


Ala Leu Val Lys Leu Gly Asn Thr Thr Val Ile Cys Gly Val Lys Ala 
    50                  55                  60                  


Glu Phe Ala Ala Pro Ser Thr Asp Ala Pro Asp Lys Gly Tyr Val Val 
65                  70                  75                  80  


Pro Asn Val Asp Leu Pro Pro Leu Cys Ser Ser Arg Phe Arg Ser Gly 
                85                  90                  95      


Pro Pro Gly Glu Glu Ala Gln Val Ala Ser Gln Phe Ile Ala Asp Val 
            100                 105                 110         


Ile Glu Asn Ser Gln Ile Ile Gln Lys Glu Asp Leu Cys Ile Ser Pro 
        115                 120                 125             


Gly Lys Leu Val Trp Val Leu Tyr Cys Asp Leu Ile Cys Leu Asp Tyr 
    130                 135                 140                 


Asp Gly Asn Ile Leu Asp Ala Cys Thr Phe Ala Leu Leu Ala Ala Leu 
145                 150                 155                 160 


Lys Asn Val Gln Leu Pro Glu Val Thr Ile Asn Glu Glu Thr Ala Leu 
                165                 170                 175     


Ala Glu Val Asn Leu Lys Lys Lys Ser Tyr Leu Asn Ile Arg Thr His 
            180                 185                 190         


Pro Val Ala Thr Ser Phe Ala Val Phe Asp Asp Thr Leu Leu Ile Val 
        195                 200                 205             


Asp Pro Thr Gly Glu Glu Glu His Leu Ala Thr Gly Thr Leu Thr Ile 
    210                 215                 220                 


Val Met Asp Glu Glu Gly Lys Leu Cys Cys Leu His Lys Pro Gly Gly 
225                 230                 235                 240 


Ser Gly Leu Thr Gly Ala Lys Leu Gln Asp Cys Met Ser Arg Ala Val 
                245                 250                 255     


Thr Arg His Lys Glu Val Lys Lys Leu Met Asp Glu Val Ile Lys Ser 
            260                 265                 270         


Met Lys Pro Lys 
        275     


<210>  475
<211>  209
<212>  PRT
<213>  Homo sapiens

<400>  475

Met Asp Ser Asp Glu Thr Gly Phe Glu His Ser Gly Leu Trp Val Ser 
1               5                   10                  15      


Val Leu Ala Gly Leu Leu Leu Gly Ala Cys Gln Ala His Pro Ile Pro 
            20                  25                  30          


Asp Ser Ser Pro Leu Leu Gln Phe Gly Gly Gln Val Arg Gln Arg Tyr 
        35                  40                  45              


Leu Tyr Thr Asp Asp Ala Gln Gln Thr Glu Ala His Leu Glu Ile Arg 
    50                  55                  60                  


Glu Asp Gly Thr Val Gly Gly Ala Ala Asp Gln Ser Pro Glu Ser Leu 
65                  70                  75                  80  


Leu Gln Leu Lys Ala Leu Lys Pro Gly Val Ile Gln Ile Leu Gly Val 
                85                  90                  95      


Lys Thr Ser Arg Phe Leu Cys Gln Arg Pro Asp Gly Ala Leu Tyr Gly 
            100                 105                 110         


Ser Leu His Phe Asp Pro Glu Ala Cys Ser Phe Arg Glu Leu Leu Leu 
        115                 120                 125             


Glu Asp Gly Tyr Asn Val Tyr Gln Ser Glu Ala His Gly Leu Pro Leu 
    130                 135                 140                 


His Leu Pro Gly Asn Lys Ser Pro His Arg Asp Pro Ala Pro Arg Gly 
145                 150                 155                 160 


Pro Ala Arg Phe Leu Pro Leu Pro Gly Leu Pro Pro Ala Pro Pro Glu 
                165                 170                 175     


Pro Pro Gly Ile Leu Ala Pro Gln Pro Pro Asp Val Gly Ser Ser Asp 
            180                 185                 190         


Pro Leu Ser Met Val Gly Pro Ser Gln Gly Arg Ser Pro Ser Tyr Ala 
        195                 200                 205             


Ser 
    


<210>  476
<211>  137
<212>  PRT
<213>  Homo sapiens

<400>  476

Met Thr Met Glu Thr Val Glu Ser Gln His Asp Gly Ser Ile Thr Ala 
1               5                   10                  15      


Ser Leu Thr Glu Ser Lys Ser Ala His Val Gln Thr Gln Thr Gly Gln 
            20                  25                  30          


Asn Ser Ile Pro Ala Leu Ala Gln Val Ala Ala Ile Ala Glu Thr Asp 
        35                  40                  45              


Glu Ser Ala Glu Ser Glu Gly Val Ile Asp Ser His Lys Arg Arg Glu 
    50                  55                  60                  


Ile Leu Ser Arg Arg Pro Ser Tyr Arg Lys Ile Leu Asn Glu Leu Ser 
65                  70                  75                  80  


Ser Asp Val Pro Gly Val Pro Lys Ile Glu Glu Glu Arg Ser Glu Glu 
                85                  90                  95      


Glu Gly Thr Pro Pro Ser Ile Ala Thr Met Ala Val Pro Thr Ser Ile 
            100                 105                 110         


Tyr Gln Thr Ser Thr Gly Gln Tyr Ser Met Tyr Ala Ala Ile Arg Tyr 
        115                 120                 125             


Asp Thr Val Leu Ala Leu Ser Leu Leu 
    130                 135         


<210>  477
<211>  22
<212>  PRT
<213>  Homo sapiens

<400>  477

Met Glu Gly Ser Leu Cys Ser Ser Tyr Pro Ser Ser Ala Leu Gly Leu 
1               5                   10                  15      


Ala Thr Ala Pro Ala Phe 
            20          


<210>  478
<211>  120
<212>  PRT
<213>  Homo sapiens

<400>  478

Met Ala Gly Asn His Cys Glu Leu Leu Pro Leu Ala Arg Gly Arg Leu 
1               5                   10                  15      


Gly Ala Gly Leu Gly Trp Leu Leu Val Pro Pro Leu Lys Arg Gly Ala 
            20                  25                  30          


Gln Arg Pro Gly Pro Ala Pro Gln Gln Gln Val Gln Val Gly Pro Ala 
        35                  40                  45              


Leu Gln Arg Arg His Leu Leu Pro His His Trp Ala Asp Ala Ala Val 
    50                  55                  60                  


Ser Gly Pro Glu Ile Leu Pro Val Pro Leu Glu Pro Gly Arg Pro Arg 
65                  70                  75                  80  


Pro Gly Leu Gly Gln Asp Gly Val Leu Phe Leu Leu Pro Lys Leu Glu 
                85                  90                  95      


Tyr Asn Gly Thr Ile Leu Ala His His Asn Leu Cys His Leu Gly Ser 
            100                 105                 110         


Ser Glu Ser Pro Pro Ser Val Ser 
        115                 120 


<210>  479
<211>  527
<212>  PRT
<213>  Homo sapiens

<400>  479

Met Ala Asp Ser Arg Asp Pro Ala Ser Asp Gln Met Gln His Trp Lys 
1               5                   10                  15      


Glu Gln Arg Ala Ala Gln Lys Ala Asp Val Leu Thr Thr Gly Ala Gly 
            20                  25                  30          


Asn Pro Val Gly Asp Lys Leu Asn Val Ile Thr Val Gly Pro Arg Gly 
        35                  40                  45              


Pro Leu Leu Val Gln Asp Val Val Phe Thr Asp Glu Met Ala His Phe 
    50                  55                  60                  


Asp Arg Glu Arg Ile Pro Glu Arg Val Val His Ala Lys Gly Ala Gly 
65                  70                  75                  80  


Ala Phe Gly Tyr Phe Glu Val Thr His Asp Ile Thr Lys Tyr Ser Lys 
                85                  90                  95      


Ala Lys Val Phe Glu His Ile Gly Lys Lys Thr Pro Ile Ala Val Arg 
            100                 105                 110         


Phe Ser Thr Val Ala Gly Glu Ser Gly Ser Ala Asp Thr Val Arg Asp 
        115                 120                 125             


Pro Arg Gly Phe Ala Val Lys Phe Tyr Thr Glu Asp Gly Asn Trp Asp 
    130                 135                 140                 


Leu Val Gly Asn Asn Thr Pro Ile Phe Phe Ile Arg Asp Pro Ile Leu 
145                 150                 155                 160 


Phe Pro Ser Phe Ile His Ser Gln Lys Arg Asn Pro Gln Thr His Leu 
                165                 170                 175     


Lys Asp Pro Asp Met Val Trp Asp Phe Trp Ser Leu Arg Pro Glu Ser 
            180                 185                 190         


Leu His Gln Val Ser Phe Leu Phe Ser Asp Arg Gly Ile Pro Asp Gly 
        195                 200                 205             


His Arg His Met Asn Gly Tyr Gly Ser His Thr Phe Lys Leu Val Asn 
    210                 215                 220                 


Ala Asn Gly Glu Ala Val Tyr Cys Lys Phe His Tyr Lys Thr Asp Gln 
225                 230                 235                 240 


Gly Ile Lys Asn Leu Ser Val Glu Asp Ala Ala Arg Leu Ser Gln Glu 
                245                 250                 255     


Asp Pro Asp Tyr Gly Ile Arg Asp Leu Phe Asn Ala Ile Ala Thr Gly 
            260                 265                 270         


Lys Tyr Pro Ser Trp Thr Phe Tyr Ile Gln Val Met Thr Phe Asn Gln 
        275                 280                 285             


Ala Glu Thr Phe Pro Phe Asn Pro Phe Asp Leu Thr Lys Val Trp Pro 
    290                 295                 300                 


His Lys Asp Tyr Pro Leu Ile Pro Val Gly Lys Leu Val Leu Asn Arg 
305                 310                 315                 320 


Asn Pro Val Asn Tyr Phe Ala Glu Val Glu Gln Ile Ala Phe Asp Pro 
                325                 330                 335     


Ser Asn Met Pro Pro Gly Ile Glu Ala Ser Pro Asp Lys Met Leu Gln 
            340                 345                 350         


Gly Arg Leu Phe Ala Tyr Pro Asp Thr His Arg His Arg Leu Gly Pro 
        355                 360                 365             


Asn Tyr Leu His Ile Pro Val Asn Cys Pro Tyr Arg Ala Arg Val Ala 
    370                 375                 380                 


Asn Tyr Gln Arg Asp Gly Pro Met Cys Met Gln Asp Asn Gln Gly Gly 
385                 390                 395                 400 


Ala Pro Asn Tyr Tyr Pro Asn Ser Phe Gly Ala Pro Glu Gln Gln Pro 
                405                 410                 415     


Ser Ala Leu Glu His Ser Ile Gln Tyr Ser Gly Glu Val Arg Arg Phe 
            420                 425                 430         


Asn Thr Ala Asn Asp Asp Asn Val Thr Gln Val Arg Ala Phe Tyr Val 
        435                 440                 445             


Asn Val Leu Asn Glu Glu Gln Arg Lys Arg Leu Cys Glu Asn Ile Ala 
    450                 455                 460                 


Gly His Leu Lys Asp Ala Gln Ile Phe Ile Gln Lys Lys Ala Val Lys 
465                 470                 475                 480 


Asn Phe Thr Glu Val His Pro Asp Tyr Gly Ser His Ile Gln Ala Leu 
                485                 490                 495     


Leu Asp Lys Tyr Asn Ala Glu Lys Pro Lys Asn Ala Ile His Thr Phe 
            500                 505                 510         


Val Gln Ser Gly Ser His Leu Ala Ala Arg Glu Lys Ala Asn Leu 
        515                 520                 525         


<210>  480
<211>  529
<212>  PRT
<213>  Homo sapiens

<400>  480

Met Glu Pro Asp Ser Val Ile Glu Asp Lys Thr Ile Glu Leu Met Asn 
1               5                   10                  15      


Thr Ser Val Met Glu Asp Gln Asn Glu Asp Glu Ser Pro Lys Lys Asn 
            20                  25                  30          


Thr Leu Trp Gln Ile Ser Asn Gly Thr Ser Ser Val Ile Val Ser Arg 
        35                  40                  45              


Lys Arg Pro Ser Glu Gly Asn Tyr Gln Lys Glu Lys Asp Leu Cys Ile 
    50                  55                  60                  


Lys Tyr Phe Asp Gln Trp Ser Glu Ser Asp Gln Val Glu Phe Val Glu 
65                  70                  75                  80  


His Leu Ile Ser Arg Met Cys His Tyr Gln His Gly His Ile Asn Ser 
                85                  90                  95      


Tyr Leu Lys Pro Met Leu Gln Arg Asp Phe Ile Thr Ala Leu Pro Glu 
            100                 105                 110         


Gln Gly Leu Asp His Ile Ala Glu Asn Ile Leu Ser Tyr Leu Asp Ala 
        115                 120                 125             


Arg Ser Leu Cys Ala Ala Glu Leu Val Cys Lys Glu Trp Gln Arg Val 
    130                 135                 140                 


Ile Ser Glu Gly Met Leu Trp Lys Lys Leu Ile Glu Arg Met Val Arg 
145                 150                 155                 160 


Thr Asp Pro Leu Trp Lys Gly Leu Ser Glu Arg Arg Gly Trp Asp Gln 
                165                 170                 175     


Tyr Leu Phe Lys Asn Arg Pro Thr Asp Gly Pro Pro Asn Ser Phe Tyr 
            180                 185                 190         


Arg Ser Leu Tyr Pro Lys Ile Ile Gln Asp Ile Glu Thr Ile Glu Ser 
        195                 200                 205             


Asn Trp Arg Cys Gly Arg His Asn Leu Gln Arg Ile Gln Cys Arg Ser 
    210                 215                 220                 


Glu Asn Ser Lys Gly Val Tyr Cys Leu Gln Tyr Asp Asp Glu Lys Ile 
225                 230                 235                 240 


Ile Ser Gly Leu Arg Asp Asn Ser Ile Lys Ile Trp Asp Lys Thr Ser 
                245                 250                 255     


Leu Glu Cys Leu Lys Val Leu Thr Gly His Thr Gly Ser Val Leu Cys 
            260                 265                 270         


Leu Gln Tyr Asp Glu Arg Val Ile Val Thr Gly Ser Ser Asp Ser Thr 
        275                 280                 285             


Val Arg Val Trp Asp Val Asn Thr Gly Glu Val Leu Asn Thr Leu Ile 
    290                 295                 300                 


His His Asn Glu Ala Val Leu His Leu Arg Phe Ser Asn Gly Leu Met 
305                 310                 315                 320 


Val Thr Cys Ser Lys Asp Arg Ser Ile Ala Val Trp Asp Met Ala Ser 
                325                 330                 335     


Ala Thr Asp Ile Thr Leu Arg Arg Val Leu Val Gly His Arg Ala Ala 
            340                 345                 350         


Val Asn Val Val Asp Phe Asp Asp Lys Tyr Ile Val Ser Ala Ser Gly 
        355                 360                 365             


Asp Arg Thr Ile Lys Val Trp Ser Thr Ser Thr Cys Glu Phe Val Arg 
    370                 375                 380                 


Thr Leu Asn Gly His Lys Arg Gly Ile Ala Cys Leu Gln Tyr Arg Asp 
385                 390                 395                 400 


Arg Leu Val Val Ser Gly Ser Ser Asp Asn Thr Ile Arg Leu Trp Asp 
                405                 410                 415     


Ile Glu Cys Gly Ala Cys Leu Arg Val Leu Glu Gly His Glu Glu Leu 
            420                 425                 430         


Val Arg Cys Ile Arg Phe Asp Asn Lys Arg Ile Val Ser Gly Ala Tyr 
        435                 440                 445             


Asp Gly Lys Ile Lys Val Trp Asp Leu Gln Ala Ala Leu Asp Pro Arg 
    450                 455                 460                 


Ala Pro Ala Ser Thr Leu Cys Leu Arg Thr Leu Val Glu His Ser Gly 
465                 470                 475                 480 


Arg Val Phe Arg Leu Gln Phe Asp Glu Phe Gln Ile Ile Ser Ser Ser 
                485                 490                 495     


His Asp Asp Thr Ile Leu Ile Trp Asp Phe Leu Asn Val Pro Pro Ser 
            500                 505                 510         


Ala Gln Asn Glu Thr Arg Ser Pro Ser Arg Thr Tyr Thr Tyr Ile Ser 
        515                 520                 525             


Arg 
    


<210>  481
<211>  199
<212>  PRT
<213>  Homo sapiens

<400>  481

Met Glu Ala Arg Asp Lys Gln Val Leu Arg Ser Leu Arg Leu Glu Leu 
1               5                   10                  15      


Gly Ala Glu Val Leu Val Glu Gly Leu Val Leu Gln Tyr Leu Tyr Gln 
            20                  25                  30          


Glu Gly Ile Leu Thr Glu Asn His Ile Gln Glu Ile Asn Ala Gln Thr 
        35                  40                  45              


Thr Gly Leu Arg Lys Thr Met Leu Leu Leu Asp Ile Leu Pro Ser Arg 
    50                  55                  60                  


Gly Pro Lys Ala Phe Asp Thr Phe Leu Asp Ser Leu Gln Glu Phe Pro 
65                  70                  75                  80  


Trp Val Arg Glu Lys Leu Lys Lys Ala Arg Glu Glu Ala Met Thr Asp 
                85                  90                  95      


Leu Pro Ala Gly Asp Arg Leu Thr Gly Ile Pro Ser His Ile Leu Asn 
            100                 105                 110         


Ser Ser Pro Ser Asp Arg Gln Ile Asn Gln Leu Ala Gln Arg Leu Gly 
        115                 120                 125             


Pro Glu Trp Glu Pro Met Val Leu Ser Leu Gly Leu Ser Gln Thr Asp 
    130                 135                 140                 


Ile Tyr Arg Cys Lys Ala Asn His Pro His Asn Val Gln Ser Gln Val 
145                 150                 155                 160 


Val Glu Ala Phe Ile Arg Trp Arg Gln Arg Phe Gly Lys Gln Ala Thr 
                165                 170                 175     


Phe Gln Ser Leu His Asn Gly Leu Arg Ala Val Glu Val Asp Pro Ser 
            180                 185                 190         


Leu Leu Leu His Met Leu Glu 
        195                 


<210>  482
<211>  468
<212>  PRT
<213>  Homo sapiens

<400>  482

Met Asp Ser Pro Ser Pro Met Asp Pro His Met Ala Glu Gln Thr Phe 
1               5                   10                  15      


Glu Gln Ala Ile Gln Ala Ala Ser Arg Ile Ile Arg Asn Glu Gln Phe 
            20                  25                  30          


Ala Ile Arg Arg Phe Gln Ser Met Pro Val Arg Leu Leu Gly His Ser 
        35                  40                  45              


Pro Val Leu Arg Asn Ile Thr Asn Ser Gln Ala Pro Asp Gly Arg Arg 
    50                  55                  60                  


Lys Ser Glu Ala Gly Ser Gly Ala Ala Ser Ser Ser Gly Glu Asp Lys 
65                  70                  75                  80  


Glu Asn Asp Gly Phe Val Phe Lys Met Pro Trp Lys Pro Thr His Pro 
                85                  90                  95      


Ser Ser Thr His Ala Leu Ala Glu Trp Ala Ser Arg Arg Glu Ala Phe 
            100                 105                 110         


Ala Gln Arg Pro Ser Ser Ala Pro Asp Leu Met Cys Leu Ser Pro Asp 
        115                 120                 125             


Arg Lys Met Glu Val Glu Glu Leu Ser Pro Leu Ala Leu Gly Arg Phe 
    130                 135                 140                 


Ser Leu Thr Pro Ala Glu Gly Asp Thr Glu Glu Asp Asp Gly Phe Val 
145                 150                 155                 160 


Asp Ile Leu Glu Ser Asp Leu Lys Asp Asp Asp Ala Val Pro Pro Gly 
                165                 170                 175     


Met Glu Ser Leu Ile Ser Ala Pro Leu Val Lys Thr Leu Glu Lys Glu 
            180                 185                 190         


Glu Glu Lys Asp Leu Val Met Tyr Ser Lys Cys Gln Arg Leu Phe Arg 
        195                 200                 205             


Ser Pro Ser Met Pro Cys Ser Val Ile Arg Pro Ile Leu Lys Arg Leu 
    210                 215                 220                 


Glu Arg Pro Gln Asp Arg Asp Thr Pro Val Gln Asn Lys Arg Arg Arg 
225                 230                 235                 240 


Ser Val Thr Pro Pro Glu Glu Gln Gln Glu Ala Glu Glu Pro Lys Ala 
                245                 250                 255     


Arg Val Leu Arg Ser Lys Ser Leu Cys His Asp Glu Ile Glu Asn Leu 
            260                 265                 270         


Leu Asp Ser Asp His Arg Glu Leu Ile Gly Asp Tyr Ser Lys Ala Phe 
        275                 280                 285             


Leu Leu Gln Thr Val Asp Gly Lys His Gln Asp Leu Lys Tyr Ile Ser 
    290                 295                 300                 


Pro Glu Thr Met Val Ala Leu Leu Thr Gly Lys Phe Ser Asn Ile Val 
305                 310                 315                 320 


Asp Lys Phe Val Ile Val Asp Cys Arg Tyr Pro Tyr Glu Tyr Glu Gly 
                325                 330                 335     


Gly His Ile Lys Thr Ala Val Asn Leu Pro Leu Glu Arg Asp Ala Glu 
            340                 345                 350         


Ser Phe Leu Leu Lys Ser Pro Ile Ala Pro Cys Ser Leu Asp Lys Arg 
        355                 360                 365             


Val Ile Leu Ile Phe His Cys Glu Phe Ser Ser Glu Arg Gly Pro Arg 
    370                 375                 380                 


Met Cys Arg Phe Ile Arg Glu Arg Asp Arg Ala Val Asn Asp Tyr Pro 
385                 390                 395                 400 


Ser Leu Tyr Tyr Pro Glu Met Tyr Ile Leu Lys Gly Gly Tyr Lys Glu 
                405                 410                 415     


Phe Phe Pro Gln His Pro Asn Phe Cys Glu Pro Gln Asp Tyr Arg Pro 
            420                 425                 430         


Met Asn His Glu Ala Phe Lys Asp Glu Leu Lys Thr Phe Arg Leu Lys 
        435                 440                 445             


Thr Arg Ser Trp Ala Gly Glu Arg Ser Arg Arg Glu Leu Cys Ser Arg 
    450                 455                 460                 


Leu Gln Asp Gln 
465             


<210>  483
<211>  1204
<212>  PRT
<213>  Homo sapiens

<400>  483

Met Gly Gln Gln Val Gly Arg Val Gly Glu Ala Pro Gly Leu Gln Gln 
1               5                   10                  15      


Pro Gln Pro Arg Gly Ile Arg Gly Ser Ser Ala Ala Arg Pro Ser Gly 
            20                  25                  30          


Arg Arg Arg Asp Pro Ala Gly Arg Thr Thr Glu Thr Gly Phe Asn Ile 
        35                  40                  45              


Phe Thr Gln His Asp His Phe Ala Ser Cys Val Glu Asp Gly Phe Glu 
    50                  55                  60                  


Gly Asp Lys Thr Gly Gly Ser Ser Pro Glu Ala Leu His Arg Pro Tyr 
65                  70                  75                  80  


Gly Cys Asp Val Glu Pro Gln Ala Leu Asn Glu Ala Ile Arg Trp Ser 
                85                  90                  95      


Ser Lys Glu Asn Leu Leu Gly Ala Thr Glu Ser Asp Pro Asn Leu Phe 
            100                 105                 110         


Val Ala Leu Tyr Asp Phe Val Ala Ser Gly Asp Asn Thr Leu Ser Ile 
        115                 120                 125             


Thr Lys Gly Glu Lys Leu Arg Val Leu Gly Tyr Asn Gln Asn Gly Glu 
    130                 135                 140                 


Trp Ser Glu Val Arg Ser Lys Asn Gly Gln Gly Trp Val Pro Ser Asn 
145                 150                 155                 160 


Tyr Ile Thr Pro Val Asn Ser Leu Glu Lys His Ser Trp Tyr His Gly 
                165                 170                 175     


Pro Val Ser Arg Ser Ala Ala Glu Tyr Leu Leu Ser Ser Leu Ile Asn 
            180                 185                 190         


Gly Ser Phe Leu Val Arg Glu Ser Glu Ser Ser Pro Gly Gln Leu Ser 
        195                 200                 205             


Ile Ser Leu Arg Tyr Glu Gly Arg Val Tyr His Tyr Arg Ile Asn Thr 
    210                 215                 220                 


Thr Ala Asp Gly Lys Val Tyr Val Thr Ala Glu Ser Arg Phe Ser Thr 
225                 230                 235                 240 


Leu Ala Glu Leu Val His His His Ser Thr Val Ala Asp Gly Leu Val 
                245                 250                 255     


Thr Thr Leu His Tyr Pro Ala Pro Lys Cys Asn Lys Pro Thr Val Tyr 
            260                 265                 270         


Gly Val Ser Pro Ile His Asp Lys Trp Glu Met Glu Arg Thr Asp Ile 
        275                 280                 285             


Thr Met Lys His Lys Leu Gly Gly Gly Gln Tyr Gly Glu Val Tyr Val 
    290                 295                 300                 


Gly Val Trp Lys Lys Tyr Ser Leu Thr Val Ala Val Lys Thr Leu Lys 
305                 310                 315                 320 


Glu Asp Thr Met Glu Val Glu Glu Phe Leu Lys Glu Ala Ala Val Met 
                325                 330                 335     


Lys Glu Ile Lys His Pro Asn Leu Val Gln Leu Leu Gly Val Cys Thr 
            340                 345                 350         


Leu Glu Pro Pro Phe Tyr Ile Val Thr Glu Tyr Met Pro Tyr Gly Asn 
        355                 360                 365             


Leu Leu Asp Tyr Leu Arg Glu Cys Asn Arg Glu Glu Val Thr Ala Val 
    370                 375                 380                 


Val Leu Leu Tyr Met Ala Thr Gln Ile Ser Ser Ala Met Glu Tyr Leu 
385                 390                 395                 400 


Glu Lys Lys Asn Phe Ile His Arg Asp Leu Ala Ala Arg Asn Cys Leu 
                405                 410                 415     


Val Gly Glu Asn His Val Val Lys Val Ala Asp Phe Gly Leu Ser Arg 
            420                 425                 430         


Leu Met Thr Gly Asp Thr Tyr Thr Ala His Ala Gly Ala Lys Phe Pro 
        435                 440                 445             


Ile Lys Trp Thr Ala Pro Glu Ser Leu Ala Tyr Asn Thr Phe Ser Ile 
    450                 455                 460                 


Lys Ser Asp Val Trp Ala Phe Gly Val Leu Leu Trp Glu Ile Ala Thr 
465                 470                 475                 480 


Tyr Gly Met Ser Pro Tyr Pro Gly Ile Asp Leu Ser Gln Val Tyr Asp 
                485                 490                 495     


Leu Leu Glu Lys Gly Tyr Arg Met Glu Gln Pro Glu Gly Cys Pro Pro 
            500                 505                 510         


Lys Val Tyr Glu Leu Met Arg Ala Cys Trp Lys Trp Ser Pro Ala Asp 
        515                 520                 525             


Arg Pro Ser Phe Ala Glu Thr His Gln Ala Phe Glu Thr Met Phe His 
    530                 535                 540                 


Asp Ser Ser Ile Ser Glu Glu Val Ala Glu Glu Leu Gly Arg Ala Ala 
545                 550                 555                 560 


Ser Ser Ser Ser Val Val Pro Tyr Leu Pro Arg Leu Pro Ile Leu Pro 
                565                 570                 575     


Ser Lys Thr Arg Thr Leu Lys Lys Gln Val Glu Asn Lys Glu Asn Ile 
            580                 585                 590         


Glu Gly Ala Gln Asp Ala Thr Glu Asn Ser Ala Ser Ser Leu Ala Pro 
        595                 600                 605             


Gly Phe Ile Arg Gly Ala Gln Ala Ser Ser Gly Ser Pro Ala Leu Pro 
    610                 615                 620                 


Arg Lys Gln Arg Asp Lys Ser Pro Ser Ser Leu Leu Glu Asp Ala Lys 
625                 630                 635                 640 


Glu Thr Cys Phe Thr Arg Asp Arg Lys Gly Gly Phe Phe Ser Ser Phe 
                645                 650                 655     


Met Lys Lys Arg Asn Ala Pro Thr Pro Pro Lys Arg Ser Ser Ser Phe 
            660                 665                 670         


Arg Glu Met Glu Asn Gln Pro His Lys Lys Tyr Glu Leu Thr Gly Asn 
        675                 680                 685             


Phe Ser Ser Val Ala Ser Leu Gln His Ala Asp Gly Phe Ser Phe Thr 
    690                 695                 700                 


Pro Ala Gln Gln Glu Ala Asn Leu Val Pro Pro Lys Cys Tyr Gly Gly 
705                 710                 715                 720 


Ser Phe Ala Gln Arg Asn Leu Cys Asn Asp Asp Gly Gly Gly Gly Gly 
                725                 730                 735     


Gly Ser Gly Thr Ala Gly Gly Gly Trp Ser Gly Ile Thr Gly Phe Phe 
            740                 745                 750         


Thr Pro Arg Leu Ile Lys Lys Thr Leu Gly Leu Arg Ala Gly Lys Pro 
        755                 760                 765             


Thr Ala Ser Asp Asp Thr Ser Lys Pro Phe Pro Arg Ser Asn Ser Thr 
    770                 775                 780                 


Ser Ser Met Ser Ser Gly Leu Pro Glu Gln Asp Arg Met Ala Met Thr 
785                 790                 795                 800 


Leu Pro Arg Asn Cys Gln Arg Ser Lys Leu Gln Leu Glu Arg Thr Val 
                805                 810                 815     


Ser Thr Ser Ser Gln Pro Glu Glu Asn Val Asp Arg Ala Asn Asp Met 
            820                 825                 830         


Leu Pro Lys Lys Ser Glu Glu Ser Ala Ala Pro Ser Arg Glu Arg Pro 
        835                 840                 845             


Lys Ala Lys Leu Leu Pro Arg Gly Ala Thr Ala Leu Pro Leu Arg Thr 
    850                 855                 860                 


Pro Ser Gly Asp Leu Ala Ile Thr Glu Lys Asp Pro Pro Gly Val Gly 
865                 870                 875                 880 


Val Ala Gly Val Ala Ala Ala Pro Lys Gly Lys Glu Lys Asn Gly Gly 
                885                 890                 895     


Ala Arg Leu Gly Met Ala Gly Val Pro Glu Asp Gly Glu Gln Pro Gly 
            900                 905                 910         


Trp Pro Ser Pro Ala Lys Ala Ala Pro Val Leu Pro Thr Thr His Asn 
        915                 920                 925             


His Lys Val Pro Val Leu Ile Ser Pro Thr Leu Lys His Thr Pro Ala 
    930                 935                 940                 


Asp Val Gln Leu Ile Gly Thr Asp Ser Gln Gly Asn Lys Phe Lys Leu 
945                 950                 955                 960 


Leu Ser Glu His Gln Val Thr Ser Ser Gly Asp Lys Asp Arg Pro Arg 
                965                 970                 975     


Arg Val Lys Pro Lys Cys Ala Pro Pro Pro Pro Pro Val Met Arg Leu 
            980                 985                 990         


Leu Gln His Pro Ser Ile Cys Ser  Asp Pro Thr Glu Glu  Pro Thr Ala 
        995                 1000                 1005             


Leu Thr  Ala Gly Gln Ser Thr  Ser Glu Thr Gln Glu  Gly Gly Lys 
    1010                 1015                 1020             


Lys Ala  Ala Leu Gly Ala Val  Pro Ile Ser Gly Lys  Ala Gly Arg 
    1025                 1030                 1035             


Pro Val  Met Pro Pro Pro Gln  Val Pro Leu Pro Thr  Ser Ser Ile 
    1040                 1045                 1050             


Ser Pro  Ala Lys Met Ala Asn  Gly Thr Ala Gly Thr  Lys Val Ala 
    1055                 1060                 1065             


Leu Arg  Lys Thr Lys Gln Ala  Ala Glu Lys Ile Ser  Ala Asp Lys 
    1070                 1075                 1080             


Ile Ser  Lys Glu Ala Leu Leu  Glu Cys Ala Asp Leu  Leu Ser Ser 
    1085                 1090                 1095             


Ala Leu  Thr Glu Pro Val Pro  Asn Ser Gln Leu Val  Asp Thr Gly 
    1100                 1105                 1110             


His Gln  Leu Leu Asp Tyr Cys  Ser Gly Tyr Val Asp  Cys Ile Pro 
    1115                 1120                 1125             


Gln Thr  Arg Asn Lys Phe Ala  Phe Arg Glu Ala Val  Ser Lys Leu 
    1130                 1135                 1140             


Glu Leu  Ser Leu Gln Glu Leu  Gln Val Ser Ser Ala  Ala Ala Gly 
    1145                 1150                 1155             


Val Pro  Gly Thr Asn Pro Val  Leu Asn Asn Leu Leu  Ser Cys Val 
    1160                 1165                 1170             


Gln Glu  Ile Ser Asp Val Val  Gln Arg Leu Glu Ala  Cys Gln Leu 
    1175                 1180                 1185             


Gly Thr  Asp Asp Tyr Asp Ile  Pro Thr Thr His His  His His His 
    1190                 1195                 1200             


His 
    


<210>  484
<211>  361
<212>  PRT
<213>  Homo sapiens

<400>  484

Met Ser Thr Ala Arg Glu Gln Pro Ile Phe Ser Thr Arg Ala His Val 
1               5                   10                  15      


Phe Gln Ile Asp Pro Ala Thr Lys Arg Asn Trp Ile Pro Ala Gly Lys 
            20                  25                  30          


His Ala Leu Thr Val Ser Tyr Phe Tyr Asp Ala Thr Arg Asn Val Tyr 
        35                  40                  45              


Arg Ile Ile Ser Ile Gly Gly Ala Lys Ala Ile Ile Asn Ser Thr Val 
    50                  55                  60                  


Thr Pro Asn Met Thr Phe Thr Lys Thr Ser Gln Lys Phe Gly Gln Trp 
65                  70                  75                  80  


Ala Asp Ser Arg Ala Asn Thr Val Tyr Gly Leu Gly Phe Ala Ser Glu 
                85                  90                  95      


Gln His Leu Thr Gln Phe Ala Glu Lys Phe Gln Glu Val Lys Glu Ala 
            100                 105                 110         


Ala Arg Leu Ala Arg Glu Lys Ser Gln Asp Gly Gly Glu Leu Thr Ser 
        115                 120                 125             


Pro Ala Leu Gly Leu Ala Ser His Gln Val Pro Pro Ser Pro Leu Val 
    130                 135                 140                 


Ser Ala Asn Gly Pro Gly Glu Glu Lys Leu Phe Arg Ser Gln Ser Ala 
145                 150                 155                 160 


Asp Ala Pro Gly Pro Thr Glu Arg Glu Arg Leu Lys Lys Met Leu Ser 
                165                 170                 175     


Glu Gly Ser Val Gly Glu Val Gln Trp Glu Ala Glu Phe Phe Ala Leu 
            180                 185                 190         


Gln Asp Ser Asn Asn Lys Leu Ala Gly Ala Leu Arg Glu Ala Asn Ala 
        195                 200                 205             


Ala Ala Ala Gln Trp Arg Gln Gln Leu Glu Ala Gln Arg Ala Glu Ala 
    210                 215                 220                 


Glu Arg Leu Arg Gln Arg Val Ala Glu Leu Glu Ala Gln Ala Ala Ser 
225                 230                 235                 240 


Glu Val Thr Pro Thr Gly Glu Lys Glu Gly Leu Gly Gln Gly Gln Ser 
                245                 250                 255     


Leu Glu Gln Leu Glu Ala Leu Val Gln Thr Lys Asp Gln Glu Ile Gln 
            260                 265                 270         


Thr Leu Lys Ser Gln Thr Gly Gly Pro Arg Glu Ala Leu Glu Ala Ala 
        275                 280                 285             


Glu Arg Glu Glu Thr Gln Gln Lys Val Gln Asp Leu Glu Thr Arg Asn 
    290                 295                 300                 


Ala Glu Leu Glu His Gln Leu Arg Ala Met Glu Arg Ser Leu Glu Glu 
305                 310                 315                 320 


Ala Arg Ala Glu Arg Glu Arg Ala Arg Ala Glu Val Gly Arg Ala Ala 
                325                 330                 335     


Gln Leu Leu Asp Val Arg Leu Phe Glu Leu Ser Glu Leu Arg Glu Gly 
            340                 345                 350         


Leu Ala Arg Leu Ala Glu Ala Ala Pro 
        355                 360     


<210>  485
<211>  484
<212>  PRT
<213>  Homo sapiens

<400>  485

Met Arg His Ser Lys Arg Thr Tyr Cys Pro Asp Trp Asp Asp Lys Asp 
1               5                   10                  15      


Trp Asp Tyr Gly Lys Trp Arg Ser Ser Ser Ser His Lys Arg Arg Lys 
            20                  25                  30          


Arg Ser His Ser Ser Ala Gln Glu Asn Lys Arg Cys Lys Tyr Asn His 
        35                  40                  45              


Ser Lys Met Cys Asp Ser His Tyr Leu Glu Ser Arg Ser Ile Asn Glu 
    50                  55                  60                  


Lys Asp Tyr His Ser Arg Arg Tyr Ile Asp Glu Tyr Arg Asn Asp Tyr 
65                  70                  75                  80  


Thr Gln Gly Cys Glu Pro Gly His Arg Gln Arg Asp His Glu Ser Arg 
                85                  90                  95      


Tyr Gln Asn His Ser Ser Lys Ser Ser Gly Arg Ser Gly Arg Ser Ser 
            100                 105                 110         


Tyr Lys Ser Lys His Arg Ile His His Ser Thr Ser His Arg Arg Ser 
        115                 120                 125             


His Gly Lys Ser His Arg Arg Lys Arg Thr Arg Ser Val Glu Asp Asp 
    130                 135                 140                 


Glu Glu Gly His Leu Ile Cys Gln Ser Gly Asp Val Leu Ser Ala Arg 
145                 150                 155                 160 


Tyr Glu Ile Val Asp Thr Leu Gly Glu Gly Ala Phe Gly Lys Val Val 
                165                 170                 175     


Glu Cys Ile Asp His Lys Ala Gly Gly Arg His Val Ala Val Lys Ile 
            180                 185                 190         


Val Lys Asn Val Asp Arg Tyr Cys Glu Ala Ala Arg Ser Glu Ile Gln 
        195                 200                 205             


Val Leu Glu His Leu Asn Thr Thr Asp Pro Asn Ser Thr Phe Arg Cys 
    210                 215                 220                 


Val Gln Met Leu Glu Trp Phe Glu His His Gly His Ile Cys Ile Val 
225                 230                 235                 240 


Phe Glu Leu Leu Gly Leu Ser Thr Tyr Asp Phe Ile Lys Glu Asn Gly 
                245                 250                 255     


Phe Leu Pro Phe Arg Leu Asp His Ile Arg Lys Met Ala Tyr Gln Ile 
            260                 265                 270         


Cys Lys Ser Val Asn Phe Leu His Ser Asn Lys Leu Thr His Thr Asp 
        275                 280                 285             


Leu Lys Pro Glu Asn Ile Leu Phe Val Gln Ser Asp Tyr Thr Glu Ala 
    290                 295                 300                 


Tyr Asn Pro Lys Ile Lys Arg Asp Glu Arg Thr Leu Ile Asn Pro Asp 
305                 310                 315                 320 


Ile Lys Val Val Asp Phe Gly Ser Ala Thr Tyr Asp Asp Glu His His 
                325                 330                 335     


Ser Thr Leu Val Ser Thr Arg His Tyr Arg Ala Pro Glu Val Ile Leu 
            340                 345                 350         


Ala Leu Gly Trp Ser Gln Pro Cys Asp Val Trp Ser Ile Gly Cys Ile 
        355                 360                 365             


Leu Ile Glu Tyr Tyr Leu Gly Phe Thr Val Phe Pro Thr His Asp Ser 
    370                 375                 380                 


Lys Glu His Leu Ala Met Met Glu Arg Ile Leu Gly Pro Leu Pro Lys 
385                 390                 395                 400 


His Met Ile Gln Lys Thr Arg Lys Arg Lys Tyr Phe His His Asp Arg 
                405                 410                 415     


Leu Asp Trp Asp Glu His Ser Ser Ala Gly Arg Tyr Val Ser Arg Ala 
            420                 425                 430         


Cys Lys Pro Leu Lys Glu Phe Met Leu Ser Gln Asp Val Glu His Glu 
        435                 440                 445             


Arg Leu Phe Asp Leu Ile Gln Lys Met Leu Glu Tyr Asp Pro Ala Lys 
    450                 455                 460                 


Arg Ile Thr Leu Arg Glu Ala Leu Lys His Pro Phe Phe Asp Leu Leu 
465                 470                 475                 480 


Lys Lys Ser Ile 
                


<210>  486
<211>  446
<212>  PRT
<213>  Homo sapiens

<400>  486

Met Ser Tyr Tyr His His His His His His Asp Tyr Asp Ile Pro Thr 
1               5                   10                  15      


Thr Glu Asn Leu Tyr Phe Gln Gly Ala Met Leu Val Pro Arg Gly Ser 
            20                  25                  30          


Pro Trp Asp Pro Glu Phe Arg Ser Pro Pro Lys Lys Gly Leu Gly Ser 
        35                  40                  45              


Pro Thr Val His Lys Ile Ser Arg Phe Pro Leu Lys Arg Gln Val Ser 
    50                  55                  60                  


Leu Glu Ser Asn Ala Ser Met Ser Ser Asn Thr Pro Leu Val Arg Ile 
65                  70                  75                  80  


Ala Arg Leu Ser Ser Gly Glu Gly Pro Thr Leu Ala Asn Val Ser Glu 
                85                  90                  95      


Leu Glu Leu Pro Ala Asp Pro Lys Trp Glu Leu Ser Arg Ala Arg Leu 
            100                 105                 110         


Thr Leu Gly Lys Pro Leu Gly Glu Gly Cys Phe Gly Gln Val Val Met 
        115                 120                 125             


Ala Glu Ala Ile Gly Ile Asp Lys Asp Arg Ala Ala Lys Pro Val Thr 
    130                 135                 140                 


Val Ala Val Lys Met Leu Lys Asp Asp Ala Thr Asp Lys Asp Leu Ser 
145                 150                 155                 160 


Asp Leu Val Ser Glu Met Glu Met Met Lys Met Ile Gly Lys His Lys 
                165                 170                 175     


Asn Ile Ile Asn Leu Leu Gly Ala Cys Thr Gln Gly Gly Pro Leu Tyr 
            180                 185                 190         


Val Leu Val Glu Tyr Ala Ala Lys Gly Asn Leu Arg Glu Phe Leu Arg 
        195                 200                 205             


Ala Arg Arg Pro Pro Gly Leu Asp Tyr Ser Phe Asp Thr Cys Lys Pro 
    210                 215                 220                 


Pro Glu Glu Gln Leu Thr Phe Lys Asp Leu Val Ser Cys Ala Tyr Gln 
225                 230                 235                 240 


Val Ala Arg Gly Met Glu Tyr Leu Ala Ser Gln Lys Cys Ile His Arg 
                245                 250                 255     


Asp Leu Ala Ala Arg Asn Val Leu Val Thr Glu Asp Asn Val Met Lys 
            260                 265                 270         


Ile Ala Asp Phe Gly Leu Ala Arg Asp Val His Asn Leu Asp Tyr Tyr 
        275                 280                 285             


Lys Lys Thr Thr Asn Gly Arg Leu Pro Val Lys Trp Met Ala Pro Glu 
    290                 295                 300                 


Ala Leu Phe Asp Arg Val Tyr Thr His Gln Ser Asp Val Trp Ser Phe 
305                 310                 315                 320 


Gly Val Leu Leu Trp Glu Ile Phe Thr Leu Gly Gly Ser Pro Tyr Pro 
                325                 330                 335     


Gly Ile Pro Val Glu Glu Leu Phe Lys Leu Leu Lys Glu Gly His Arg 
            340                 345                 350         


Met Asp Lys Pro Ala Asn Cys Thr His Asp Leu Tyr Met Ile Met Arg 
        355                 360                 365             


Glu Cys Trp His Ala Ala Pro Ser Gln Arg Pro Thr Phe Lys Gln Leu 
    370                 375                 380                 


Val Glu Asp Leu Asp Arg Val Leu Thr Val Thr Ser Thr Asp Glu Tyr 
385                 390                 395                 400 


Leu Asp Leu Ser Ala Pro Phe Glu Gln Tyr Ser Pro Gly Gly Gln Asp 
                405                 410                 415     


Thr Pro Ser Ser Ser Ser Ser Gly Asp Asp Ser Val Phe Ala His Asp 
            420                 425                 430         


Leu Leu Pro Pro Ala Pro Pro Ser Ser Gly Gly Ser Arg Thr 
        435                 440                 445     


<210>  487
<211>  165
<212>  PRT
<213>  Homo sapiens

<400>  487

Met Lys Trp Gly Lys Lys Val Ala Cys Gly Ser Ser Glu Gly Thr Ile 
1               5                   10                  15      


Tyr Leu Phe Asn Trp Asn Gly Phe Gly Ala Thr Ser Asp Arg Phe Ala 
            20                  25                  30          


Leu Arg Ala Glu Ser Ile Asp Cys Met Val Pro Val Thr Glu Ser Leu 
        35                  40                  45              


Leu Cys Thr Gly Ser Thr Asp Gly Val Ile Arg Ala Val Asn Ile Leu 
    50                  55                  60                  


Pro Asn Arg Val Val Gly Ser Val Gly Gln His Thr Gly Glu Pro Val 
65                  70                  75                  80  


Glu Glu Leu Ala Leu Ser His Cys Gly Arg Phe Leu Ala Ser Ser Gly 
                85                  90                  95      


His Asp Gln Arg Leu Lys Phe Trp Asp Met Ala Gln Leu Arg Ala Val 
            100                 105                 110         


Val Val Asp Asp Tyr Arg Arg Arg Lys Lys Lys Gly Gly Pro Leu Arg 
        115                 120                 125             


Ala Leu Ser Ser Lys Thr Trp Ser Thr Asp Asp Phe Phe Ala Gly Leu 
    130                 135                 140                 


Arg Glu Glu Gly Glu Asp Ser Met Ala Gln Glu Glu Lys Glu Glu Thr 
145                 150                 155                 160 


Gly Asp Asp Ser Asp 
                165 


<210>  488
<211>  618
<212>  PRT
<213>  Homo sapiens

<400>  488

Met Lys His Leu Trp Phe Phe Leu Leu Leu Val Ala Ala Pro Arg Trp 
1               5                   10                  15      


Val Leu Ser Gln Val Gln Leu Gln Gln Trp Gly Ala Gly Leu Leu Lys 
            20                  25                  30          


Pro Ser Glu Thr Leu Ser Leu Thr Cys Gly Val Tyr Gly Gly Ser Phe 
        35                  40                  45              


Ser Gly Tyr Tyr Trp Ser Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu 
    50                  55                  60                  


Glu Trp Ile Gly Glu Ile Asn His Ser Gly Ser Thr Asn Tyr Asn Pro 
65                  70                  75                  80  


Ser Leu Lys Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Lys Gln 
                85                  90                  95      


Leu Ser Leu Lys Leu Ser Ser Val Asn Ala Ala Asp Thr Ala Val Tyr 
            100                 105                 110         


Tyr Cys Ala Arg Val Ile Thr Arg Ala Ser Pro Gly Thr Asp Gly Arg 
        115                 120                 125             


Tyr Gly Met Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 
    130                 135                 140                 


Gly Ser Ala Ser Ala Pro Thr Leu Phe Pro Leu Val Ser Cys Glu Asn 
145                 150                 155                 160 


Ser Pro Ser Asp Thr Ser Ser Val Ala Val Gly Cys Leu Ala Gln Asp 
                165                 170                 175     


Phe Leu Pro Asp Ser Ile Thr Phe Ser Trp Lys Tyr Lys Asn Asn Ser 
            180                 185                 190         


Asp Ile Ser Ser Thr Arg Gly Phe Pro Ser Val Leu Arg Gly Gly Lys 
        195                 200                 205             


Tyr Ala Ala Thr Ser Gln Val Leu Leu Pro Ser Lys Asp Val Met Gln 
    210                 215                 220                 


Gly Thr Asp Glu His Val Val Cys Lys Val Gln His Pro Asn Gly Asn 
225                 230                 235                 240 


Lys Glu Lys Asn Val Pro Leu Pro Val Ile Ala Glu Leu Pro Pro Lys 
                245                 250                 255     


Val Ser Val Phe Val Pro Pro Arg Asp Gly Phe Phe Gly Asn Pro Arg 
            260                 265                 270         


Lys Ser Lys Leu Ile Cys Gln Ala Thr Gly Phe Ser Pro Arg Gln Ile 
        275                 280                 285             


Gln Val Ser Trp Leu Arg Glu Gly Lys Gln Val Gly Ser Gly Val Thr 
    290                 295                 300                 


Thr Asp Gln Val Gln Ala Glu Ala Lys Glu Ser Gly Pro Thr Thr Tyr 
305                 310                 315                 320 


Lys Val Thr Ser Thr Leu Thr Ile Lys Glu Ser Asp Trp Leu Ser Gln 
                325                 330                 335     


Ser Met Phe Thr Cys Arg Val Asp His Arg Gly Leu Thr Phe Gln Gln 
            340                 345                 350         


Asn Ala Ser Ser Met Cys Val Pro Asp Gln Asp Thr Ala Ile Arg Val 
        355                 360                 365             


Phe Ala Ile Pro Pro Ser Phe Ala Ser Ile Phe Leu Thr Lys Ser Thr 
    370                 375                 380                 


Lys Leu Thr Cys Leu Val Thr Asp Leu Thr Thr Tyr Asp Ser Val Thr 
385                 390                 395                 400 


Ile Ser Trp Thr Arg Gln Asn Gly Glu Ala Val Lys Thr His Thr Asn 
                405                 410                 415     


Ile Ser Glu Ser His Pro Asn Ala Thr Phe Ser Ala Val Gly Glu Ala 
            420                 425                 430         


Ser Ile Cys Glu Asp Asp Trp Asn Ser Gly Glu Arg Phe Thr Cys Thr 
        435                 440                 445             


Val Thr His Thr Asp Leu Pro Ser Pro Leu Lys Gln Thr Ile Ser Arg 
    450                 455                 460                 


Pro Lys Gly Val Ala Leu His Arg Pro Asp Val Tyr Leu Leu Pro Pro 
465                 470                 475                 480 


Ala Arg Glu Gln Leu Asn Leu Arg Glu Ser Ala Thr Ile Thr Cys Leu 
                485                 490                 495     


Val Thr Gly Phe Ser Pro Ala Asp Val Phe Val Gln Trp Met Gln Arg 
            500                 505                 510         


Gly Gln Pro Leu Ser Pro Glu Lys Tyr Val Thr Ser Ala Pro Met Pro 
        515                 520                 525             


Glu Pro Gln Ala Pro Gly Arg Tyr Phe Ala His Ser Ile Leu Thr Val 
    530                 535                 540                 


Ser Glu Glu Glu Trp Asn Thr Gly Glu Thr Tyr Thr Cys Val Val Ala 
545                 550                 555                 560 


His Glu Ala Leu Pro Asn Arg Val Thr Glu Arg Thr Val Asp Lys Ser 
                565                 570                 575     


Thr Glu Gly Glu Val Ser Ala Asp Glu Glu Gly Phe Glu Asn Leu Trp 
            580                 585                 590         


Ala Thr Ala Ser Thr Phe Ile Val Leu Phe Leu Leu Ser Leu Phe Tyr 
        595                 600                 605             


Ser Thr Thr Val Thr Leu Phe Lys Val Lys 
    610                 615             


<210>  489
<211>  244
<212>  PRT
<213>  Homo sapiens

<400>  489

Met Met Arg Thr Gln Cys Leu Leu Gly Leu Arg Thr Phe Val Ala Phe 
1               5                   10                  15      


Ala Ala Lys Leu Trp Ser Phe Phe Ile Tyr Leu Leu Arg Arg Gln Ile 
            20                  25                  30          


Arg Thr Val Ile Gln Tyr Gln Thr Val Arg Tyr Asp Ile Leu Pro Leu 
        35                  40                  45              


Ser Pro Val Ser Arg Asn Arg Leu Ala Gln Val Lys Arg Lys Ile Leu 
    50                  55                  60                  


Val Leu Asp Leu Asp Glu Thr Leu Ile His Ser His His Asp Gly Val 
65                  70                  75                  80  


Leu Arg Pro Thr Val Arg Pro Gly Thr Pro Pro Asp Phe Ile Leu Lys 
                85                  90                  95      


Val Val Ile Asp Lys His Pro Val Arg Phe Phe Val His Lys Arg Pro 
            100                 105                 110         


His Val Asp Phe Phe Leu Glu Val Val Ser Gln Trp Tyr Glu Leu Val 
        115                 120                 125             


Val Phe Thr Ala Ser Met Glu Ile Tyr Gly Ser Ala Val Ala Asp Lys 
    130                 135                 140                 


Leu Asp Asn Ser Arg Ser Ile Leu Lys Arg Arg Tyr Tyr Arg Gln His 
145                 150                 155                 160 


Cys Thr Leu Glu Leu Gly Ser Tyr Ile Lys Asp Leu Ser Val Val His 
                165                 170                 175     


Ser Asp Leu Ser Ser Ile Val Ile Leu Asp Asn Ser Pro Gly Ala Tyr 
            180                 185                 190         


Arg Ser His Pro Asp Asn Ala Ile Pro Ile Lys Ser Trp Phe Ser Asp 
        195                 200                 205             


Pro Ser Asp Thr Ala Leu Leu Asn Leu Leu Pro Met Leu Asp Ala Leu 
    210                 215                 220                 


Arg Phe Thr Ala Asp Val Arg Ser Val Leu Ser Arg Asn Leu His Gln 
225                 230                 235                 240 


His Arg Leu Trp 
                


<210>  490
<211>  123
<212>  PRT
<213>  Homo sapiens

<400>  490

Met Asn Pro Val Tyr Ser Pro Gly Ser Ser Gly Val Pro Tyr Ala Asn 
1               5                   10                  15      


Ala Lys Gly Ile Gly Tyr Pro Ala Gly Phe Pro Met Gly Tyr Ala Ala 
            20                  25                  30          


Ala Ala Pro Ala Tyr Ser Pro Asn Met Tyr Pro Gly Ala Asn Pro Thr 
        35                  40                  45              


Phe Gln Thr Gly Tyr Thr Pro Gly Thr Pro Tyr Lys Val Ser Cys Ser 
    50                  55                  60                  


Pro Thr Ser Gly Ala Val Pro Pro Tyr Ser Ser Ser Pro Gln Ala Val 
65                  70                  75                  80  


Pro Met Ser Pro Cys Ala Asp Gln Trp Ala Arg Gln Leu Gly Gln Ile 
                85                  90                  95      


Ser Gly Gln Pro Phe Val Leu Leu Ala Gly Leu Leu Cys Trp Pro His 
            100                 105                 110         


Gly Glu Ala Leu Glu Ser Leu Met Asp Cys Asn 
        115                 120             


<210>  491
<211>  666
<212>  PRT
<213>  Homo sapiens

<400>  491

Met Glu Gln Glu Pro Gln Asn Gly Glu Pro Ala Glu Ile Lys Ile Ile 
1               5                   10                  15      


Arg Glu Ala Tyr Lys Lys Ala Phe Leu Phe Val Asn Lys Gly Leu Asn 
            20                  25                  30          


Thr Asp Glu Leu Gly Gln Lys Glu Glu Ala Lys Asn Tyr Tyr Lys Gln 
        35                  40                  45              


Gly Ile Gly His Leu Leu Arg Gly Ile Ser Ile Ser Ser Lys Glu Ser 
    50                  55                  60                  


Glu His Thr Gly Thr Gly Trp Glu Ser Ala Arg Gln Met Gln Gln Lys 
65                  70                  75                  80  


Met Lys Glu Thr Leu Gln Asn Val Arg Thr Arg Leu Glu Ile Leu Glu 
                85                  90                  95      


Lys Gly Leu Ala Thr Ser Leu Gln Asn Asp Leu Gln Glu Val Pro Lys 
            100                 105                 110         


Leu Tyr Pro Glu Phe Pro Pro Lys Asp Met Cys Glu Lys Leu Pro Glu 
        115                 120                 125             


Pro Gln Ser Phe Ser Ser Ala Pro Gln His Ala Glu Val Asn Gly Asn 
    130                 135                 140                 


Thr Ser Thr Pro Ser Ala Gly Ala Val Ala Ala Pro Ala Ser Leu Ser 
145                 150                 155                 160 


Leu Pro Ser Gln Ser Cys Pro Ala Glu Ala Pro Pro Ala Tyr Thr Pro 
                165                 170                 175     


Gln Ala Ala Glu Gly His Tyr Thr Val Ser Tyr Gly Thr Asp Ser Gly 
            180                 185                 190         


Glu Phe Ser Ser Val Gly Glu Glu Phe Tyr Arg Asn His Ser Gln Pro 
        195                 200                 205             


Pro Pro Leu Glu Thr Leu Gly Leu Asp Ala Asp Glu Leu Ile Leu Ile 
    210                 215                 220                 


Pro Asn Gly Val Gln Ile Phe Phe Val Asn Pro Ala Gly Glu Val Ser 
225                 230                 235                 240 


Ala Pro Ser Tyr Pro Gly Tyr Leu Arg Ile Val Arg Phe Leu Asp Asn 
                245                 250                 255     


Ser Leu Asp Thr Val Leu Asn Arg Pro Pro Gly Phe Leu Gln Val Cys 
            260                 265                 270         


Asp Trp Leu Tyr Pro Leu Val Pro Asp Arg Ser Pro Val Leu Lys Cys 
        275                 280                 285             


Thr Ala Gly Ala Tyr Met Phe Pro Asp Thr Met Leu Gln Ala Ala Gly 
    290                 295                 300                 


Cys Phe Val Gly Val Val Leu Ser Ser Glu Leu Pro Glu Asp Asp Arg 
305                 310                 315                 320 


Glu Leu Phe Glu Asp Leu Leu Arg Gln Met Ser Asp Leu Arg Leu Gln 
                325                 330                 335     


Ala Asn Trp Asn Arg Ala Glu Glu Glu Asn Glu Phe Gln Ile Pro Gly 
            340                 345                 350         


Arg Thr Arg Pro Ser Ser Asp Gln Leu Lys Glu Ala Ser Gly Thr Asp 
        355                 360                 365             


Val Lys Gln Leu Asp Gln Gly Asn Lys Asp Val Arg His Lys Gly Lys 
    370                 375                 380                 


Arg Gly Lys Arg Ala Lys Asp Thr Ser Ser Glu Glu Val Asn Leu Ser 
385                 390                 395                 400 


His Ile Val Pro Cys Glu Pro Val Pro Glu Glu Lys Pro Lys Glu Leu 
                405                 410                 415     


His Glu Trp Ser Glu Lys Val Ala His Asn Ile Leu Ser Gly Ala Ser 
            420                 425                 430         


Trp Val Ser Trp Gly Leu Val Lys Gly Ala Glu Ile Thr Gly Lys Ala 
        435                 440                 445             


Ile Gln Lys Gly Ala Ser Lys Leu Arg Glu Arg Ile Gln Pro Glu Glu 
    450                 455                 460                 


Lys Pro Val Glu Val Ser Pro Ala Val Thr Lys Gly Leu Tyr Ile Ala 
465                 470                 475                 480 


Lys Gln Ala Thr Gly Gly Ala Ala Lys Val Ser Gln Phe Leu Val Asp 
                485                 490                 495     


Gly Val Cys Thr Val Ala Asn Cys Val Gly Lys Glu Leu Ala Pro His 
            500                 505                 510         


Val Lys Lys His Gly Ser Lys Leu Val Pro Glu Ser Leu Lys Lys Asp 
        515                 520                 525             


Lys Asp Gly Lys Ser Pro Leu Asp Gly Ala Met Val Val Ala Ala Ser 
    530                 535                 540                 


Ser Val Gln Gly Phe Ser Thr Val Trp Gln Gly Leu Glu Cys Ala Ala 
545                 550                 555                 560 


Lys Cys Ile Val Asn Asn Val Ser Ala Glu Thr Val Gln Thr Val Arg 
                565                 570                 575     


Tyr Lys Tyr Gly Tyr Asn Ala Gly Glu Ala Thr His His Ala Val Asp 
            580                 585                 590         


Ser Ala Val Asn Val Gly Val Thr Ala Tyr Asn Ile Asn Asn Ile Gly 
        595                 600                 605             


Ile Lys Ala Met Val Lys Lys Thr Ala Thr Gln Thr Gly His Thr Leu 
    610                 615                 620                 


Leu Glu Asp Tyr Gln Ile Val Asp Asn Ser Gln Arg Glu Asn Gln Glu 
625                 630                 635                 640 


Gly Ala Ala Asn Val Asn Val Arg Gly Glu Lys Asp Glu Gln Thr Lys 
                645                 650                 655     


Glu Val Lys Glu Ala Lys Lys Lys Asp Lys 
            660                 665     


<210>  492
<211>  220
<212>  PRT
<213>  Homo sapiens

<400>  492

Met Ala Ser Glu Arg Leu Pro Asn Arg Pro Ala Cys Leu Leu Val Ala 
1               5                   10                  15      


Ser Gly Ala Ala Glu Gly Val Ser Ala Gln Ser Phe Leu His Cys Phe 
            20                  25                  30          


Thr Met Ala Ser Thr Ala Phe Asn Leu Gln Val Ala Thr Pro Gly Gly 
        35                  40                  45              


Lys Ala Met Glu Phe Val Asp Val Thr Glu Ser Asn Ala Arg Trp Val 
    50                  55                  60                  


Gln Asp Phe Arg Leu Lys Ala Tyr Ala Ser Pro Ala Lys Leu Glu Ser 
65                  70                  75                  80  


Ile Asp Gly Ala Arg Tyr His Ala Leu Leu Ile Pro Ser Cys Pro Gly 
                85                  90                  95      


Ala Leu Thr Asp Leu Ala Ser Ser Gly Ser Leu Ala Arg Ile Leu Gln 
            100                 105                 110         


His Phe His Ser Glu Ser Lys Pro Ile Cys Ala Val Gly His Gly Val 
        115                 120                 125             


Ala Ala Leu Cys Cys Ala Thr Asn Glu Asp Arg Ser Trp Val Phe Asp 
    130                 135                 140                 


Ser Tyr Ser Leu Thr Gly Pro Ser Val Cys Glu Leu Val Arg Ala Pro 
145                 150                 155                 160 


Gly Phe Ala Arg Leu Pro Leu Val Val Glu Asp Phe Val Lys Asp Ser 
                165                 170                 175     


Gly Ala Cys Phe Ser Ala Ser Glu Pro Asp Ala Val His Val Val Leu 
            180                 185                 190         


Asp Arg His Leu Val Thr Gly Gln Asn Ala Ser Ser Thr Val Pro Ala 
        195                 200                 205             


Val Gln Asn Leu Leu Phe Leu Cys Gly Ser Arg Lys 
    210                 215                 220 


<210>  493
<211>  354
<212>  PRT
<213>  Homo sapiens

<400>  493

Met Cys Gly Arg Thr Ser Cys His Leu Pro Arg Asp Val Leu Thr Arg 
1               5                   10                  15      


Ala Cys Ala Tyr Gln Asp Arg Arg Gly Gln Gln Arg Leu Pro Glu Trp 
            20                  25                  30          


Arg Asp Pro Asp Lys Tyr Cys Pro Ser Tyr Asn Lys Ser Pro Gln Ser 
        35                  40                  45              


Asn Ser Pro Val Leu Leu Ser Arg Leu His Phe Glu Lys Asp Ala Asp 
    50                  55                  60                  


Ser Ser Glu Arg Ile Ile Ala Pro Met Arg Trp Gly Leu Val Pro Ser 
65                  70                  75                  80  


Trp Phe Lys Glu Ser Asp Pro Ser Lys Leu Gln Phe Asn Thr Thr Asn 
                85                  90                  95      


Cys Arg Ser Asp Thr Val Met Glu Lys Arg Ser Phe Lys Val Pro Leu 
            100                 105                 110         


Gly Lys Gly Arg Arg Cys Val Val Leu Ala Asp Gly Phe Tyr Glu Trp 
        115                 120                 125             


Gln Arg Cys Gln Gly Thr Asn Gln Arg Gln Pro Tyr Phe Ile Tyr Phe 
    130                 135                 140                 


Pro Gln Ile Lys Thr Glu Lys Ser Gly Ser Ile Gly Ala Ala Asp Ser 
145                 150                 155                 160 


Pro Glu Asn Trp Glu Lys Val Trp Asp Asn Trp Arg Leu Leu Thr Met 
                165                 170                 175     


Ala Gly Ile Phe Asp Cys Trp Glu Pro Pro Glu Gly Gly Asp Val Leu 
            180                 185                 190         


Tyr Ser Tyr Thr Ile Ile Thr Val Asp Ser Cys Lys Gly Leu Ser Asp 
        195                 200                 205             


Ile His His Arg Met Pro Ala Ile Leu Asp Gly Glu Glu Ala Val Ser 
    210                 215                 220                 


Lys Trp Leu Asp Phe Gly Glu Val Ser Thr Gln Glu Ala Leu Lys Leu 
225                 230                 235                 240 


Ile His Pro Thr Glu Asn Ile Thr Phe His Ala Val Ser Ser Val Val 
                245                 250                 255     


Asn Asn Ser Arg Asn Asn Thr Pro Glu Cys Leu Ala Pro Val Asp Leu 
            260                 265                 270         


Val Val Lys Lys Glu Leu Arg Ala Ser Gly Ser Ser Gln Arg Met Leu 
        275                 280                 285             


Gln Trp Leu Ala Thr Lys Ser Pro Lys Lys Glu Asp Ser Lys Thr Pro 
    290                 295                 300                 


Gln Lys Glu Glu Ser Asp Val Pro Gln Trp Ser Ser Gln Phe Leu Gln 
305                 310                 315                 320 


Lys Ser Pro Leu Pro Thr Lys Arg Gly Thr Ala Gly Leu Leu Glu Gln 
                325                 330                 335     


Trp Leu Lys Arg Glu Lys Glu Glu Glu Pro Val Ala Lys Arg Pro Tyr 
            340                 345                 350         


Ser Gln 
        


<210>  494
<211>  138
<212>  PRT
<213>  Homo sapiens

<400>  494

Met Glu Asp Leu Thr Asn Val Ser Ser Leu Leu Asn Met Glu Arg Ala 
1               5                   10                  15      


Arg Asp Lys Ala Asn Glu Glu Gly Leu Ala Leu Leu Gln Glu Glu Ile 
            20                  25                  30          


Asp Lys Met Val Glu Thr Thr Glu Leu Met Thr Gly Asn Ile Gln Ser 
        35                  40                  45              


Leu Lys Asn Lys Ile Gln Ile Leu Ala Ser Glu Val Glu Glu Glu Glu 
    50                  55                  60                  


Glu Arg Val Lys Gln Met His Gln Ile Asn Ser Ser Gly Val Leu Ser 
65                  70                  75                  80  


Leu Pro Glu Leu Ser Gln Lys Thr Leu Lys Ala Pro Thr Leu Gln Lys 
                85                  90                  95      


Glu Ile Leu Ala Leu Ile Pro Asn Gln Asn Ala Leu Leu Lys Asp Leu 
            100                 105                 110         


Asp Ile Leu His Asn Ser Ser Gln Met Lys Ser Met Ser Thr Phe Ile 
        115                 120                 125             


Glu Glu Ala Tyr Lys Lys Leu Asp Ala Ser 
    130                 135             


<210>  495
<211>  324
<212>  PRT
<213>  Homo sapiens

<400>  495

Met Gly Pro Trp Gly Glu Pro Glu Leu Leu Val Trp Arg Pro Glu Ala 
1               5                   10                  15      


Val Ala Ser Glu Pro Pro Val Pro Val Gly Leu Glu Val Lys Leu Gly 
            20                  25                  30          


Ala Leu Val Leu Leu Leu Val Leu Thr Leu Leu Cys Ser Leu Val Pro 
        35                  40                  45              


Ile Cys Val Leu Arg Arg Pro Gly Ala Asn His Glu Gly Ser Ala Ser 
    50                  55                  60                  


Arg Gln Lys Ala Leu Ser Leu Val Ser Cys Phe Ala Gly Gly Val Phe 
65                  70                  75                  80  


Leu Ala Thr Cys Leu Leu Asp Leu Leu Pro Asp Tyr Leu Ala Ala Ile 
                85                  90                  95      


Asp Glu Ala Leu Ala Ala Leu His Val Thr Leu Gln Phe Pro Leu Gln 
            100                 105                 110         


Glu Phe Ile Leu Ala Met Gly Phe Phe Leu Val Leu Val Met Glu Gln 
        115                 120                 125             


Ile Thr Leu Ala Tyr Lys Glu Gln Ser Gly Pro Ser Pro Leu Glu Glu 
    130                 135                 140                 


Thr Arg Ala Leu Leu Gly Thr Val Asn Gly Gly Pro Gln His Trp His 
145                 150                 155                 160 


Asp Gly Pro Gly Val Pro Gln Ala Ser Gly Ala Pro Ala Thr Pro Ser 
                165                 170                 175     


Ala Leu Arg Ala Cys Val Leu Val Phe Ser Leu Ala Leu His Ser Val 
            180                 185                 190         


Phe Glu Gly Leu Ala Val Gly Leu Gln Arg Asp Arg Ala Arg Ala Met 
        195                 200                 205             


Glu Leu Cys Leu Ala Leu Leu Leu His Lys Gly Ile Leu Ala Val Ser 
    210                 215                 220                 


Leu Ser Leu Arg Leu Leu Gln Ser His Leu Arg Ala Gln Val Val Ala 
225                 230                 235                 240 


Gly Cys Gly Ile Leu Phe Ser Cys Met Thr Pro Leu Gly Ile Gly Leu 
                245                 250                 255     


Gly Ala Ala Leu Ala Glu Ser Ala Gly Pro Leu His Gln Leu Ala Gln 
            260                 265                 270         


Ser Val Leu Glu Gly Met Ala Ala Gly Thr Phe Leu Tyr Ile Thr Phe 
        275                 280                 285             


Leu Glu Ile Leu Pro Gln Glu Leu Ala Ser Ser Glu Gln Arg Ile Leu 
    290                 295                 300                 


Lys Val Ile Leu Leu Leu Ala Gly Phe Ala Leu Leu Thr Gly Leu Leu 
305                 310                 315                 320 


Phe Ile Gln Ile 
                


<210>  496
<211>  524
<212>  PRT
<213>  Homo sapiens

<400>  496

Met Glu Leu Gly Pro Glu Pro Pro His Arg Arg Arg Leu Leu Phe Ala 
1               5                   10                  15      


Cys Ser Pro Pro Pro Ala Ser Gln Pro Val Val Lys Ala Leu Phe Gly 
            20                  25                  30          


Ala Ser Ala Ala Gly Gly Leu Ser Pro Val Thr Asn Leu Thr Val Thr 
        35                  40                  45              


Met Asp Gln Leu Gln Gly Leu Gly Ser Asp Tyr Glu Gln Pro Leu Glu 
    50                  55                  60                  


Val Lys Asn Asn Ser Asn Leu Gln Arg Met Gly Ser Ser Glu Ser Thr 
65                  70                  75                  80  


Asp Ser Gly Phe Cys Leu Asp Ser Pro Gly Pro Leu Asp Ser Lys Glu 
                85                  90                  95      


Asn Leu Glu Asn Pro Met Arg Arg Ile His Ser Leu Pro Gln Lys Leu 
            100                 105                 110         


Leu Gly Cys Ser Pro Ala Leu Lys Arg Ser His Ser Asp Ser Leu Asp 
        115                 120                 125             


His Asp Ile Phe Gln Leu Ile Asp Pro Asp Glu Asn Lys Glu Asn Glu 
    130                 135                 140                 


Ala Phe Glu Phe Lys Lys Pro Val Arg Pro Val Ser Arg Gly Cys Leu 
145                 150                 155                 160 


His Ser His Gly Leu Gln Glu Gly Lys Asp Leu Phe Thr Gln Arg Gln 
                165                 170                 175     


Asn Ser Ala Pro Ala Arg Met Leu Ser Ser Asn Glu Arg Asp Ser Ser 
            180                 185                 190         


Glu Pro Gly Asn Phe Ile Pro Leu Phe Thr Pro Gln Ser Pro Val Thr 
        195                 200                 205             


Ala Thr Leu Ser Asp Glu Asp Asp Gly Phe Val Asp Leu Leu Asp Gly 
    210                 215                 220                 


Glu Asn Leu Lys Asn Glu Glu Glu Thr Pro Ser Cys Met Ala Ser Leu 
225                 230                 235                 240 


Trp Thr Ala Pro Leu Val Met Arg Thr Thr Asn Leu Asp Asn Arg Cys 
                245                 250                 255     


Lys Leu Phe Asp Ser Pro Ser Leu Cys Ser Ser Ser Thr Arg Ser Val 
            260                 265                 270         


Leu Lys Arg Pro Glu Arg Ser Gln Glu Glu Ser Pro Pro Gly Ser Thr 
        275                 280                 285             


Lys Arg Arg Lys Ser Met Ser Gly Ala Ser Pro Lys Glu Ser Thr Asn 
    290                 295                 300                 


Pro Glu Lys Ala His Glu Thr Leu His Gln Ser Leu Ser Leu Ala Ser 
305                 310                 315                 320 


Ser Pro Lys Gly Thr Ile Glu Asn Ile Leu Asp Asn Asp Pro Arg Asp 
                325                 330                 335     


Leu Ile Gly Asp Phe Ser Lys Gly Tyr Leu Phe His Thr Val Ala Gly 
            340                 345                 350         


Lys His Gln Asp Leu Lys Tyr Ile Ser Pro Glu Ile Met Ala Ser Val 
        355                 360                 365             


Leu Asn Gly Lys Phe Ala Asn Leu Ile Lys Glu Phe Val Ile Ile Asp 
    370                 375                 380                 


Cys Arg Tyr Pro Tyr Glu Tyr Glu Gly Gly His Ile Lys Gly Ala Val 
385                 390                 395                 400 


Asn Leu His Met Glu Glu Glu Val Glu Asp Phe Leu Leu Lys Lys Pro 
                405                 410                 415     


Ile Val Pro Thr Asp Gly Lys Arg Val Ile Val Val Phe His Cys Glu 
            420                 425                 430         


Phe Ser Ser Glu Arg Gly Pro Arg Met Cys Arg Tyr Val Arg Glu Arg 
        435                 440                 445             


Asp Arg Leu Gly Asn Glu Tyr Pro Lys Leu His Tyr Pro Glu Leu Tyr 
    450                 455                 460                 


Val Leu Lys Gly Gly Tyr Lys Glu Phe Phe Met Lys Cys Gln Ser Tyr 
465                 470                 475                 480 


Cys Glu Pro Pro Ser Tyr Arg Pro Met His His Glu Asp Phe Lys Glu 
                485                 490                 495     


Asp Leu Lys Lys Phe Arg Thr Lys Ser Arg Thr Trp Ala Gly Glu Lys 
            500                 505                 510         


Ser Lys Arg Glu Met Tyr Ser Arg Leu Lys Lys Leu 
        515                 520                 


<210>  497
<211>  246
<212>  PRT
<213>  Homo sapiens

<400>  497

Met Ser Ile Tyr Lys Glu Pro Pro Pro Gly Met Phe Val Val Pro Asp 
1               5                   10                  15      


Thr Val Asp Met Thr Lys Ile His Ala Leu Ile Thr Gly Pro Phe Asp 
            20                  25                  30          


Thr Pro Tyr Glu Gly Gly Phe Phe Leu Phe Val Phe Arg Cys Pro Pro 
        35                  40                  45              


Asp Tyr Pro Ile His Pro Pro Arg Val Lys Leu Met Thr Thr Gly Asn 
    50                  55                  60                  


Asn Thr Val Arg Phe Asn Pro Asn Phe Tyr Arg Asn Gly Lys Val Cys 
65                  70                  75                  80  


Leu Ser Ile Leu Gly Thr Trp Thr Gly Pro Ala Trp Ser Pro Ala Gln 
                85                  90                  95      


Ser Ile Ser Ser Val Leu Ile Ser Ile Gln Ser Leu Met Thr Glu Asn 
            100                 105                 110         


Pro Tyr His Asn Glu Pro Gly Phe Glu Gln Glu Arg His Pro Gly Asp 
        115                 120                 125             


Ser Lys Asn Tyr Asn Glu Cys Ile Arg His Glu Thr Ile Arg Val Ala 
    130                 135                 140                 


Val Cys Asp Met Met Glu Gly Lys Cys Pro Cys Pro Glu Pro Leu Arg 
145                 150                 155                 160 


Gly Val Met Glu Lys Ser Phe Leu Glu Tyr Tyr Asp Phe Tyr Glu Val 
                165                 170                 175     


Ala Cys Lys Asp Arg Leu His Leu Gln Gly Gln Thr Met Gln Asp Pro 
            180                 185                 190         


Phe Gly Glu Lys Arg Gly His Phe Asp Tyr Gln Ser Leu Leu Met Arg 
        195                 200                 205             


Leu Gly Leu Ile Arg Gln Lys Val Leu Glu Arg Leu His Asn Glu Asn 
    210                 215                 220                 


Ala Glu Met Asp Ser Asp Ser Ser Ser Ser Gly Thr Glu Thr Asp Leu 
225                 230                 235                 240 


His Gly Ser Leu Arg Val 
                245     


<210>  498
<211>  185
<212>  PRT
<213>  Homo sapiens

<400>  498

Met Ala Asp Gly Gly Gly Gly Gly Gly Thr Gly Ala Val Gly Gly Gly 
1               5                   10                  15      


Gly Thr Ser Gln Ala Ser Ala Gly Ala Ala Thr Gly Ala Thr Gly Ala 
            20                  25                  30          


Ser Gly Gly Gly Gly Pro Ile Asn Pro Ala Ser Leu Pro Pro Gly Asp 
        35                  40                  45              


Pro Gln Leu Ile Ala Leu Ile Val Glu Gln Leu Lys Ser Arg Gly Leu 
    50                  55                  60                  


Phe Asp Ser Phe Arg Arg Asp Cys Leu Ala Asp Val Asp Thr Lys Pro 
65                  70                  75                  80  


Ala Tyr Gln Asn Leu Arg Gln Lys Val Asp Asn Phe Val Ser Thr His 
                85                  90                  95      


Leu Asp Lys Gln Glu Trp Asn Pro Thr Met Asn Lys Asn Gln Leu Arg 
            100                 105                 110         


Asn Gly Leu Arg Gln Ser Val Val Gln Ser Gly Met Leu Glu Ala Gly 
        115                 120                 125             


Val Asp Arg Ile Ile Ser Gln Val Val Asp Pro Lys Leu Asn His Ile 
    130                 135                 140                 


Phe Arg Pro Gln Ile Glu Arg Ala Ile His Glu Phe Leu Ala Ala Gln 
145                 150                 155                 160 


Lys Lys Ala Ala Val Pro Ala Pro Pro Pro Glu Pro Glu Gly Gln Asp 
                165                 170                 175     


Pro Pro Ala Pro Ser Gln Asp Thr Ser 
            180                 185 


<210>  499
<211>  120
<212>  PRT
<213>  Homo sapiens

<400>  499

Met Ile Val Thr Gly Gln Tyr Gly Arg Leu Phe Ala Val Val His Phe 
1               5                   10                  15      


Ala Ser Arg Gln Trp Lys Val Thr Ser Glu Asp Leu Ile Leu Ile Gly 
            20                  25                  30          


Asn Glu Leu Asp Leu Ala Cys Gly Glu Arg Ile Arg Leu Glu Lys Val 
        35                  40                  45              


Leu Leu Val Gly Ala Asp Asn Phe Thr Leu Leu Gly Lys Pro Leu Leu 
    50                  55                  60                  


Gly Lys Asp Leu Val Arg Val Glu Ala Thr Val Ile Glu Lys Thr Glu 
65                  70                  75                  80  


Ser Trp Pro Arg Ile Ile Met Arg Phe Arg Lys Arg Lys Asn Phe Lys 
                85                  90                  95      


Lys Lys Arg Ile Val Thr Thr Pro Gln Thr Val Leu Arg Ile Asn Ser 
            100                 105                 110         


Ile Glu Ile Ala Pro Cys Leu Leu 
        115                 120 


<210>  500
<211>  457
<212>  PRT
<213>  Homo sapiens

<400>  500

Met Glu Phe Leu Leu Gly Asn Pro Phe Ser Thr Pro Val Gly Gln Cys 
1               5                   10                  15      


Leu Glu Lys Ala Thr Asp Gly Ser Leu Gln Ser Glu Asp Trp Thr Leu 
            20                  25                  30          


Asn Met Glu Ile Cys Asp Ile Ile Asn Glu Thr Glu Glu Gly Pro Lys 
        35                  40                  45              


Asp Ala Ile Arg Ala Leu Lys Lys Arg Leu Asn Gly Asn Arg Asn Tyr 
    50                  55                  60                  


Arg Glu Val Met Leu Ala Leu Thr Ala Trp Ala Asp Ala Phe Arg Ser 
65                  70                  75                  80  


Ser Pro Asp Leu Thr Gly Val Val His Ile Tyr Glu Glu Leu Lys Arg 
                85                  90                  95      


Lys Gly Val Glu Phe Pro Met Ala Asp Leu Asp Ala Leu Ser Pro Ile 
            100                 105                 110         


His Thr Pro Gln Arg Ser Val Pro Glu Val Asp Pro Ala Ala Thr Met 
        115                 120                 125             


Pro Arg Ser Gln Ser Gln Gln Arg Thr Ser Ala Gly Ser Tyr Ser Ser 
    130                 135                 140                 


Pro Pro Pro Ala Pro Tyr Ser Ala Pro Gln Ala Pro Ala Leu Ser Val 
145                 150                 155                 160 


Thr Gly Pro Ile Thr Ala Asn Ser Glu Gln Ile Ala Arg Leu Arg Ser 
                165                 170                 175     


Glu Leu Asp Val Val Arg Gly Asn Thr Lys Val Met Ser Glu Met Leu 
            180                 185                 190         


Thr Glu Met Val Pro Gly Gln Glu Asp Ser Ser Asp Leu Glu Leu Leu 
        195                 200                 205             


Gln Glu Leu Asn Arg Thr Cys Arg Ala Met Gln Gln Arg Ile Val Glu 
    210                 215                 220                 


Leu Ile Ser Arg Val Ser Asn Glu Glu Val Thr Glu Glu Leu Leu His 
225                 230                 235                 240 


Val Asn Asp Asp Leu Asn Asn Val Phe Leu Arg Tyr Glu Arg Phe Glu 
                245                 250                 255     


Arg Tyr Arg Ser Gly Arg Ser Val Gln Asn Ala Ser Asn Gly Val Leu 
            260                 265                 270         


Asn Glu Val Thr Glu Asp Asn Leu Ile Asp Leu Gly Pro Gly Ser Pro 
        275                 280                 285             


Ala Val Val Ser Pro Met Val Gly Asn Thr Ala Pro Pro Ser Ser Leu 
    290                 295                 300                 


Ser Ser Gln Leu Ala Gly Leu Asp Leu Gly Thr Glu Ser Val Ser Gly 
305                 310                 315                 320 


Thr Leu Ser Ser Leu Gln Gln Cys Asn Pro Arg Asp Gly Phe Asp Met 
                325                 330                 335     


Phe Ala Gln Thr Arg Gly Asn Ser Leu Ala Glu Gln Arg Lys Thr Val 
            340                 345                 350         


Thr Tyr Glu Asp Pro Gln Ala Val Gly Gly Leu Ala Ser Ala Leu Asp 
        355                 360                 365             


Asn Arg Lys Gln Ser Ser Glu Gly Ile Pro Val Ala Gln Pro Ser Val 
    370                 375                 380                 


Met Asp Asp Ile Glu Val Trp Leu Arg Thr Asp Leu Lys Gly Asp Asp 
385                 390                 395                 400 


Leu Glu Glu Gly Val Thr Ser Glu Glu Phe Asp Lys Phe Leu Glu Glu 
                405                 410                 415     


Arg Ala Lys Ala Ala Glu Met Val Pro Asp Leu Pro Ser Pro Pro Met 
            420                 425                 430         


Glu Ala Pro Ala Pro Ala Ser Asn Pro Ser Gly Arg Lys Lys Pro Glu 
        435                 440                 445             


Arg Ser Glu Asp Ala Leu Phe Ala Leu 
    450                 455         


<210>  501
<211>  392
<212>  PRT
<213>  Homo sapiens

<400>  501

Met Ser Ala Gln Ala Gln Met Arg Ala Met Leu Asp Gln Leu Met Gly 
1               5                   10                  15      


Thr Ser Arg Asp Gly Asp Thr Thr Arg Gln Arg Ile Lys Phe Ser Asp 
            20                  25                  30          


Asp Arg Val Cys Lys Ser His Leu Leu Asn Cys Cys Pro His Asp Val 
        35                  40                  45              


Leu Ser Gly Thr Arg Met Asp Leu Gly Glu Cys Leu Lys Val His Asp 
    50                  55                  60                  


Leu Ala Leu Arg Ala Asp Tyr Glu Ile Ala Ser Lys Glu Gln Asp Phe 
65                  70                  75                  80  


Phe Phe Glu Leu Asp Ala Met Asp His Leu Gln Ser Phe Ile Ala Asp 
                85                  90                  95      


Cys Asp Arg Arg Thr Glu Val Ala Lys Lys Arg Leu Ala Glu Thr Gln 
            100                 105                 110         


Glu Glu Ile Ser Ala Glu Val Ala Ala Lys Ala Glu Arg Val His Glu 
        115                 120                 125             


Leu Asn Glu Glu Ile Gly Lys Leu Leu Ala Lys Val Glu Gln Leu Gly 
    130                 135                 140                 


Ala Glu Gly Asn Val Glu Glu Ser Gln Lys Val Met Asp Glu Val Glu 
145                 150                 155                 160 


Lys Ala Arg Ala Lys Lys Arg Glu Ala Glu Glu Val Tyr Arg Asn Ser 
                165                 170                 175     


Met Pro Ala Ser Ser Phe Gln Gln Gln Lys Leu Arg Val Cys Glu Val 
            180                 185                 190         


Cys Ser Ala Tyr Leu Gly Leu His Asp Asn Asp Arg Arg Leu Ala Asp 
        195                 200                 205             


His Phe Gly Gly Lys Leu His Leu Gly Phe Ile Glu Ile Arg Glu Lys 
    210                 215                 220                 


Leu Glu Glu Leu Lys Arg Val Val Ala Glu Lys Gln Glu Lys Arg Asn 
225                 230                 235                 240 


Gln Glu Arg Leu Lys Arg Arg Glu Glu Arg Glu Arg Glu Glu Arg Glu 
                245                 250                 255     


Lys Leu Arg Arg Ser Arg Ser His Ser Lys Asn Pro Lys Arg Ser Arg 
            260                 265                 270         


Ser Arg Glu His Arg Arg His Arg Ser Arg Ser Met Ser Arg Glu Arg 
        275                 280                 285             


Lys Arg Arg Thr Arg Ser Lys Ser Arg Glu Lys Arg His Arg His Arg 
    290                 295                 300                 


Ser Arg Ser Ser Ser Arg Ser Arg Ser Arg Ser His Gln Arg Ser Arg 
305                 310                 315                 320 


His Ser Ser Arg Asp Arg Ser Arg Glu Arg Ser Lys Arg Arg Ser Ser 
                325                 330                 335     


Lys Glu Arg Phe Arg Asp Gln Asp Leu Ala Ser Cys Asp Arg Asp Arg 
            340                 345                 350         


Ser Ser Arg Asp Arg Ser Pro Arg Asp Arg Asp Arg Lys Asp Lys Lys 
        355                 360                 365             


Arg Ser Tyr Glu Ser Ala Asn Gly Arg Ser Glu Asp Arg Arg Ser Ser 
    370                 375                 380                 


Glu Glu Arg Glu Ala Gly Glu Ile 
385                 390         


<210>  502
<211>  615
<212>  PRT
<213>  Homo sapiens

<400>  502

Ser Thr Ile Gln Ser Glu Thr Asp Cys Tyr Asp Ile Ile Glu Val Leu 
1               5                   10                  15      


Gly Lys Gly Thr Phe Gly Glu Val Ala Lys Gly Trp Arg Arg Ser Thr 
            20                  25                  30          


Gly Glu Met Val Ala Ile Lys Ile Leu Lys Asn Asp Ala Tyr Arg Asn 
        35                  40                  45              


Arg Ile Ile Lys Asn Glu Leu Lys Leu Leu His Cys Met Arg Gly Leu 
    50                  55                  60                  


Asp Pro Glu Glu Ala His Val Ile Arg Phe Leu Glu Phe Phe His Asp 
65                  70                  75                  80  


Ala Leu Lys Phe Tyr Leu Val Phe Glu Leu Leu Glu Gln Asn Leu Phe 
                85                  90                  95      


Glu Phe Gln Lys Glu Asn Asn Phe Ala Pro Leu Pro Ala Arg His Ile 
            100                 105                 110         


Arg Thr Val Thr Leu Gln Val Leu Thr Ala Leu Ala Arg Leu Lys Glu 
        115                 120                 125             


Leu Ala Ile Ile His Ala Asp Leu Lys Pro Glu Asn Ile Met Leu Val 
    130                 135                 140                 


Asp Gln Thr Arg Cys Pro Phe Arg Val Lys Val Ile Asp Phe Gly Ser 
145                 150                 155                 160 


Ala Ser Ile Phe Ser Glu Val Arg Tyr Val Lys Glu Pro Tyr Ile Gln 
                165                 170                 175     


Ser Arg Phe Tyr Arg Ala Pro Glu Ile Leu Leu Gly Leu Pro Phe Cys 
            180                 185                 190         


Glu Lys Val Asp Val Trp Ser Leu Gly Cys Val Met Ala Glu Leu His 
        195                 200                 205             


Leu Gly Trp Pro Leu Tyr Pro Gly Asn Asn Glu Tyr Asp Gln Val Arg 
    210                 215                 220                 


Tyr Ile Cys Glu Thr Gln Gly Leu Pro Lys Pro His Leu Leu His Ala 
225                 230                 235                 240 


Ala Cys Lys Ala His His Phe Phe Lys Arg Asn Pro His Pro Asp Ala 
                245                 250                 255     


Ala Asn Pro Trp Gln Leu Lys Ser Ser Ala Asp Tyr Leu Ala Glu Thr 
            260                 265                 270         


Lys Val Arg Pro Leu Glu Arg Arg Lys Tyr Met Leu Lys Ser Leu Asp 
        275                 280                 285             


Gln Ile Glu Thr Val Asn Gly Gly Ser Val Ala Ser Arg Leu Thr Phe 
    290                 295                 300                 


Pro Asp Arg Glu Ala Leu Ala Glu His Ala Asp Leu Lys Ser Met Val 
305                 310                 315                 320 


Glu Leu Ile Lys Arg Met Leu Thr Trp Glu Ser His Glu Arg Ile Ser 
                325                 330                 335     


Pro Ser Ala Ala Leu Arg His Pro Phe Val Ser Met Gln Gln Leu Arg 
            340                 345                 350         


Ser Ala His Glu Thr Thr His Tyr Tyr Gln Leu Ser Leu Arg Ser Tyr 
        355                 360                 365             


Arg Leu Ser Leu Gln Val Glu Gly Lys Pro Pro Thr Pro Val Val Ala 
    370                 375                 380                 


Ala Glu Asp Gly Thr Pro Tyr Tyr Cys Leu Ala Glu Glu Lys Glu Ala 
385                 390                 395                 400 


Ala Gly Met Gly Ser Val Ala Gly Ser Ser Pro Phe Phe Arg Glu Glu 
                405                 410                 415     


Lys Ala Pro Gly Met Gln Arg Ala Ile Asp Gln Leu Asp Asp Leu Ser 
            420                 425                 430         


Leu Gln Glu Ala Gly His Gly Leu Trp Gly Glu Thr Cys Thr Asn Ala 
        435                 440                 445             


Val Ser Asp Met Met Val Pro Leu Lys Ala Ala Ile Thr Gly His His 
    450                 455                 460                 


Val Pro Asp Ser Gly Pro Glu Pro Ile Leu Ala Phe Tyr Ser Ser Arg 
465                 470                 475                 480 


Leu Ala Gly Arg His Lys Ala Arg Lys Pro Pro Ala Gly Ser Lys Ser 
                485                 490                 495     


Asp Ser Asn Phe Ser Asn Leu Ile Arg Leu Ser Gln Val Ser Pro Glu 
            500                 505                 510         


Asp Asp Arg Pro Cys Arg Gly Ser Ser Trp Glu Glu Gly Glu His Leu 
        515                 520                 525             


Gly Ala Ser Ala Glu Pro Leu Ala Ile Leu Gln Arg Asp Glu Asp Gly 
    530                 535                 540                 


Pro Asn Ile Asp Asn Met Thr Met Glu Ala Glu Arg Pro Asp Pro Glu 
545                 550                 555                 560 


Leu Phe Asp Pro Ser Ser Cys Pro Gly Glu Trp Leu Ser Glu Pro Asp 
                565                 570                 575     


Cys Thr Leu Glu Ser Val Arg Gly Pro Arg Ala Gln Gly Leu Pro Pro 
            580                 585                 590         


Arg Arg Ser His Gln His Gly Pro Pro Arg Gly Ala Thr Ser Phe Leu 
        595                 600                 605             


Gln His Val Thr Gly His His 
    610                 615 


<210>  503
<211>  381
<212>  PRT
<213>  Homo sapiens

<400>  503

Met Glu Ser Gly Ser Thr Ala Ala Ser Glu Glu Ala Arg Ser Leu Arg 
1               5                   10                  15      


Glu Cys Glu Leu Tyr Val Gln Lys His Asn Ile Gln Ala Leu Leu Lys 
            20                  25                  30          


Asp Ser Ile Val Gln Leu Cys Thr Ala Arg Pro Glu Arg Pro Met Ala 
        35                  40                  45              


Phe Leu Arg Glu Tyr Phe Glu Arg Leu Glu Lys Glu Glu Ala Lys Gln 
    50                  55                  60                  


Ile Gln Asn Leu Gln Lys Ala Gly Thr Arg Thr Asp Ser Arg Glu Asp 
65                  70                  75                  80  


Glu Ile Ser Pro Pro Pro Pro Asn Pro Val Val Lys Gly Arg Arg Arg 
                85                  90                  95      


Arg Gly Ala Ile Ser Ala Glu Val Tyr Thr Glu Glu Asp Ala Ala Ser 
            100                 105                 110         


Tyr Val Arg Lys Val Ile Pro Lys Asp Tyr Lys Thr Met Ala Ala Leu 
        115                 120                 125             


Ala Lys Ala Ile Glu Lys Asn Val Leu Phe Ser His Leu Asp Asp Asn 
    130                 135                 140                 


Glu Arg Ser Asp Ile Phe Asp Ala Met Phe Ser Val Ser Phe Ile Ala 
145                 150                 155                 160 


Gly Glu Thr Val Ile Gln Gln Gly Asp Glu Gly Asp Asn Phe Tyr Val 
                165                 170                 175     


Ile Asp Gln Gly Glu Thr Asp Val Tyr Val Asn Asn Glu Trp Ala Thr 
            180                 185                 190         


Ser Val Gly Glu Gly Gly Ser Phe Gly Glu Leu Ala Leu Ile Tyr Gly 
        195                 200                 205             


Thr Pro Arg Ala Ala Thr Val Lys Ala Lys Thr Asn Val Lys Leu Trp 
    210                 215                 220                 


Gly Ile Asp Arg Asp Ser Tyr Arg Arg Ile Leu Met Gly Ser Thr Leu 
225                 230                 235                 240 


Arg Lys Arg Lys Met Tyr Glu Glu Phe Leu Ser Lys Val Ser Ile Leu 
                245                 250                 255     


Glu Ser Leu Asp Lys Trp Glu Arg Leu Thr Val Ala Asp Ala Leu Glu 
            260                 265                 270         


Pro Val Gln Phe Glu Asp Gly Gln Lys Ile Val Val Gln Gly Glu Pro 
        275                 280                 285             


Gly Asp Glu Phe Phe Ile Ile Leu Glu Gly Ser Ala Ala Val Leu Gln 
    290                 295                 300                 


Arg Arg Ser Glu Asn Glu Glu Phe Val Glu Val Gly Arg Leu Gly Pro 
305                 310                 315                 320 


Ser Asp Tyr Phe Gly Glu Ile Ala Leu Leu Met Asn Arg Pro Arg Ala 
                325                 330                 335     


Ala Thr Val Val Ala Arg Gly Pro Leu Lys Cys Val Lys Leu Asp Arg 
            340                 345                 350         


Pro Arg Phe Glu Arg Val Leu Gly Pro Cys Ser Asp Ile Leu Lys Arg 
        355                 360                 365             


Asn Ile Gln Gln Tyr Asn Ser Phe Val Ser Leu Ser Val 
    370                 375                 380     


<210>  504
<211>  192
<212>  PRT
<213>  Homo sapiens

<400>  504

Met Glu Trp Lys Leu Glu Arg Thr Ala Pro Arg Arg Val Arg Thr Glu 
1               5                   10                  15      


Glu Glu Met Leu Trp Val Leu Asp Ser Val Asn Ala Thr Tyr Ser Asp 
            20                  25                  30          


Phe Lys Ser Asn Phe Ala Lys Arg Leu Ser Ala Glu Val Pro Val Ala 
        35                  40                  45              


Ser Ser Pro Ile Thr Thr Arg Trp Gln Gln Ser Gln Thr Arg Ala Leu 
    50                  55                  60                  


Ser Ser Asp Ser Phe Gly Glu Glu Gln Ser Thr Thr Tyr Leu Pro Glu 
65                  70                  75                  80  


Ala Ser Gly Ser Val Leu Lys Thr Pro Pro Glu Lys Glu Thr Leu Thr 
                85                  90                  95      


Leu Gly Ser Cys Lys Glu Gln Leu Lys Thr Pro Ser Lys Gly Ile Ser 
            100                 105                 110         


Glu Thr Ser Asn Ser Ala Leu His Phe Cys Lys Ala Pro His Ala Met 
        115                 120                 125             


Asp Arg Asp Trp Lys Glu Ser Val Ala Ser Lys Gly Gln Lys Cys Leu 
    130                 135                 140                 


Lys Gln Leu Phe Val Thr Gln Asn Val Val Gln Gln Ala Asn Gly Lys 
145                 150                 155                 160 


Met Gln Leu Cys Glu Gln Ser Glu Cys Val Trp Lys Asp His Phe Ser 
                165                 170                 175     


Gly Ser Met Lys Lys Arg Phe Glu Gln Glu Asp Val Gly Gly Lys Asp 
            180                 185                 190         


<210>  505
<211>  109
<212>  PRT
<213>  Homo sapiens

<400>  505

Met Glu Pro Asn Ser Pro Lys Lys Ile Gln Phe Ala Val Pro Val Phe 
1               5                   10                  15      


Gln Ser Gln Ile Ala Pro Glu Ala Ala Glu Gln Ile Arg Lys Arg Arg 
            20                  25                  30          


Pro Thr Pro Ala Ser Leu Val Ile Leu Asn Glu His Asn Pro Pro Glu 
        35                  40                  45              


Ile Asp Asp Lys Arg Gly Pro Asn Thr Gln Gly Glu Leu Gln Asn Ala 
    50                  55                  60                  


Ser Pro Lys Gln Arg Lys Gln Ser Val Tyr Thr Pro Pro Thr Ile Lys 
65                  70                  75                  80  


Gly Val Lys His Leu Lys Gly Gln Asn Glu Ser Ala Phe Pro Glu Glu 
                85                  90                  95      


Glu Glu Gly Thr Asn Glu Arg Glu Glu Gln Arg Asp His 
            100                 105                 


<210>  506
<211>  392
<212>  PRT
<213>  Homo sapiens

<400>  506

Met Thr Ile Asn Ile Gln Glu His Met Ala Ile Asn Val Cys Pro Gly 
1               5                   10                  15      


Pro Ile Arg Pro Ile Arg Gln Ile Ser Asp Tyr Phe Pro Arg Gly Pro 
            20                  25                  30          


Gly Pro Glu Gly Gly Gly Gly Gly Gly Gly Glu Ala Pro Ala His Leu 
        35                  40                  45              


Val Pro Leu Ala Leu Ala Pro Pro Ala Ala Leu Leu Gly Ala Thr Thr 
    50                  55                  60                  


Pro Glu Asp Gly Ala Glu Val Asp Ser Tyr Asp Ser Asp Asp Ala Thr 
65                  70                  75                  80  


Ala Leu Gly Thr Leu Glu Phe Asp Leu Leu Tyr Asp Arg Ala Ser Cys 
                85                  90                  95      


Thr Leu His Cys Ser Ile Leu Arg Ala Lys Gly Leu Lys Pro Met Asp 
            100                 105                 110         


Phe Asn Gly Leu Ala Asp Pro Tyr Val Lys Leu His Leu Leu Pro Gly 
        115                 120                 125             


Ala Cys Lys Ala Asn Lys Leu Lys Thr Lys Thr Gln Arg Asn Thr Leu 
    130                 135                 140                 


Asn Pro Val Trp Asn Glu Asp Leu Thr Tyr Ser Gly Ile Thr Asp Asp 
145                 150                 155                 160 


Asp Ile Thr His Lys Val Leu Arg Ile Ala Val Cys Asp Glu Asp Lys 
                165                 170                 175     


Leu Ser His Asn Glu Phe Ile Gly Glu Ile Arg Val Pro Leu Arg Arg 
            180                 185                 190         


Leu Lys Pro Ser Gln Lys Lys His Phe Asn Ile Cys Leu Glu Arg Gln 
        195                 200                 205             


Val Pro Leu Ala Ser Pro Ser Ser Met Ser Ala Ala Leu Arg Gly Ile 
    210                 215                 220                 


Ser Cys Tyr Leu Lys Glu Leu Glu Gln Ala Glu Gln Gly Gln Gly Leu 
225                 230                 235                 240 


Leu Glu Glu Arg Gly Arg Ile Leu Leu Ser Leu Ser Tyr Ser Ser Arg 
                245                 250                 255     


Arg Arg Gly Leu Leu Val Gly Ile Leu Arg Cys Ala His Leu Ala Ala 
            260                 265                 270         


Met Asp Val Asn Gly Tyr Ser Asp Pro Tyr Val Lys Thr Tyr Leu Arg 
        275                 280                 285             


Pro Asp Val Asp Lys Lys Ser Lys His Lys Thr Cys Val Lys Lys Lys 
    290                 295                 300                 


Thr Leu Asn Pro Glu Phe Asn Glu Glu Phe Phe Tyr Glu Ile Glu Leu 
305                 310                 315                 320 


Ser Thr Leu Ala Thr Lys Thr Leu Glu Val Thr Val Trp Asp Tyr Asp 
                325                 330                 335     


Ile Gly Lys Ser Asn Asp Phe Ile Gly Gly Val Ser Leu Gly Pro Gly 
            340                 345                 350         


Ala Arg Gly Glu Ala Arg Lys His Trp Ser Asp Cys Leu Gln Gln Pro 
        355                 360                 365             


Asp Ala Ala Leu Glu Arg Trp His Thr Leu Thr Ser Glu Leu Pro Pro 
    370                 375                 380                 


Ala Ala Gly Ala Leu Ser Ser Ala 
385                 390         


<210>  507
<211>  246
<212>  PRT
<213>  Homo sapiens

<400>  507

Met Ser Trp Ala Ala Val Leu Ala Val Ala Ala Ala Arg Phe Gly His 
1               5                   10                  15      


Phe Trp Gly Cys Arg Trp Pro Gly Pro Met Ala Gln Gly Trp Ala Gly 
            20                  25                  30          


Phe Ser Glu Glu Glu Leu Arg Arg Leu Lys Gln Thr Lys Asp Pro Phe 
        35                  40                  45              


Glu Pro Gln Arg Arg Leu Pro Ala Lys Lys Ser Arg Gln Gln Leu Gln 
    50                  55                  60                  


Arg Glu Lys Ala Leu Val Glu Gln Ser Gln Lys Leu Gly Leu Gln Asp 
65                  70                  75                  80  


Gly Ser Thr Ser Leu Leu Pro Glu Gln Leu Leu Ser Ala Pro Lys Gln 
                85                  90                  95      


Arg Val Asn Val Gln Lys Pro Pro Phe Ser Ser Pro Thr Leu Pro Ser 
            100                 105                 110         


His Phe Thr Leu Thr Ser Pro Val Gly Asp Gly Gln Pro Gln Gly Ile 
        115                 120                 125             


Glu Ser Gln Pro Lys Glu Leu Gly Leu Glu Asn Ser His Asp Gly His 
    130                 135                 140                 


Asn Asn Val Glu Ile Leu Pro Pro Lys Pro Asp Cys Lys Leu Glu Lys 
145                 150                 155                 160 


Lys Lys Val Glu Leu Gln Glu Lys Ser Arg Trp Glu Val Leu Gln Gln 
                165                 170                 175     


Glu Gln Arg Leu Met Glu Glu Lys Asn Lys Arg Lys Lys Ala Leu Leu 
            180                 185                 190         


Ala Lys Ala Ile Ala Glu Arg Ser Lys Arg Thr Gln Ala Glu Thr Met 
        195                 200                 205             


Lys Leu Lys Arg Ile Gln Lys Glu Leu Gln Ala Leu Asp Asp Met Val 
    210                 215                 220                 


Ser Ala Asp Ile Gly Ile Leu Arg Asn Arg Ile Asp Gln Ala Ser Leu 
225                 230                 235                 240 


Asp Tyr Ser Tyr Ala Arg 
                245     


<210>  508
<211>  350
<212>  PRT
<213>  Homo sapiens

<400>  508

Met Leu Gly Ser Val Lys Met Glu Ala His Asp Leu Ala Glu Trp Ser 
1               5                   10                  15      


Tyr Tyr Pro Glu Ala Gly Glu Val Tyr Ser Pro Val Thr Pro Val Pro 
            20                  25                  30          


Thr Met Ala Pro Leu Asn Ser Tyr Met Thr Leu Asn Pro Leu Ser Ser 
        35                  40                  45              


Pro Tyr Pro Pro Gly Gly Leu Pro Ala Ser Pro Leu Pro Ser Gly Pro 
    50                  55                  60                  


Leu Ala Pro Pro Ala Pro Ala Ala Pro Leu Gly Pro Thr Phe Pro Gly 
65                  70                  75                  80  


Leu Gly Val Ser Gly Gly Ser Ser Ser Ser Gly Tyr Gly Ala Pro Gly 
                85                  90                  95      


Pro Gly Leu Val His Gly Lys Glu Met Pro Lys Gly Tyr Arg Arg Pro 
            100                 105                 110         


Leu Ala His Ala Lys Pro Pro Tyr Ser Tyr Ile Ser Leu Ile Thr Met 
        115                 120                 125             


Ala Ile Gln Gln Ala Pro Gly Lys Met Leu Thr Leu Ser Glu Ile Tyr 
    130                 135                 140                 


Gln Trp Ile Met Asp Leu Phe Pro Tyr Tyr Arg Glu Asn Gln Gln Arg 
145                 150                 155                 160 


Trp Gln Asn Ser Ile Arg His Ser Leu Ser Phe Asn Asp Cys Phe Val 
                165                 170                 175     


Lys Val Ala Arg Ser Pro Asp Lys Pro Gly Lys Gly Ser Tyr Trp Ala 
            180                 185                 190         


Leu His Pro Ser Ser Gly Asn Met Phe Glu Asn Gly Cys Tyr Leu Arg 
        195                 200                 205             


Arg Gln Lys Arg Phe Lys Leu Glu Glu Lys Val Lys Lys Gly Gly Ser 
    210                 215                 220                 


Gly Ala Ala Thr Thr Thr Arg Asn Gly Thr Gly Ser Ala Ala Ser Thr 
225                 230                 235                 240 


Thr Thr Pro Ala Ala Thr Val Thr Ser Pro Pro Gln Pro Pro Pro Pro 
                245                 250                 255     


Ala Pro Glu Pro Glu Ala Gln Gly Gly Glu Asp Val Gly Ala Leu Asp 
            260                 265                 270         


Cys Gly Ser Pro Ala Ser Ser Thr Pro Tyr Phe Thr Gly Leu Glu Leu 
        275                 280                 285             


Pro Gly Glu Leu Lys Leu Asp Ala Pro Tyr Asn Phe Asn His Pro Phe 
    290                 295                 300                 


Ser Ile Asn Asn Leu Met Ser Glu Gln Thr Pro Ala Pro Pro Lys Leu 
305                 310                 315                 320 


Asp Val Gly Phe Gly Gly Tyr Gly Ala Glu Gly Gly Glu Pro Gly Val 
                325                 330                 335     


Tyr Tyr Gln Gly Leu Tyr Ser Arg Ser Leu Leu Asn Ala Ser 
            340                 345                 350 


<210>  509
<211>  260
<212>  PRT
<213>  Homo sapiens

<400>  509

Met Lys Val Glu Val Leu Pro Ala Leu Thr Asp Asn Tyr Met Tyr Leu 
1               5                   10                  15      


Val Ile Asp Asp Glu Thr Lys Glu Ala Ala Ile Val Asp Pro Val Gln 
            20                  25                  30          


Pro Gln Lys Val Val Asp Ala Ala Arg Lys His Gly Val Lys Leu Thr 
        35                  40                  45              


Thr Val Leu Thr Thr His His His Trp Asp His Ala Gly Gly Asn Glu 
    50                  55                  60                  


Lys Leu Val Lys Leu Glu Ser Gly Leu Lys Val Tyr Gly Gly Asp Asp 
65                  70                  75                  80  


Arg Ile Gly Ala Leu Thr His Lys Ile Thr His Leu Ser Thr Leu Gln 
                85                  90                  95      


Val Gly Ser Leu Asn Val Lys Cys Leu Ala Thr Pro Cys His Thr Ser 
            100                 105                 110         


Gly His Ile Cys Tyr Phe Val Ser Lys Pro Gly Gly Ser Glu Pro Pro 
        115                 120                 125             


Ala Val Phe Thr Gly Asp Thr Leu Phe Val Ala Gly Cys Gly Lys Phe 
    130                 135                 140                 


Tyr Glu Gly Thr Ala Asp Glu Met Cys Lys Ala Leu Leu Glu Val Leu 
145                 150                 155                 160 


Gly Arg Leu Pro Pro Asp Thr Arg Val Tyr Cys Gly His Glu Tyr Thr 
                165                 170                 175     


Ile Asn Asn Leu Lys Phe Ala Arg His Val Glu Pro Gly Asn Ala Ala 
            180                 185                 190         


Ile Arg Glu Lys Leu Ala Trp Ala Lys Glu Lys Tyr Ser Ile Gly Glu 
        195                 200                 205             


Pro Thr Val Pro Ser Thr Leu Ala Glu Glu Phe Thr Tyr Asn Pro Phe 
    210                 215                 220                 


Met Arg Val Arg Glu Lys Thr Val Gln Gln His Ala Gly Glu Thr Asp 
225                 230                 235                 240 


Pro Val Thr Thr Met Arg Ala Val Arg Arg Glu Lys Asp Gln Phe Lys 
                245                 250                 255     


Met Pro Arg Asp 
            260 


<210>  510
<211>  242
<212>  PRT
<213>  Homo sapiens

<400>  510

Met Pro Gly Pro Trp Leu Leu Leu Ala Leu Ala Leu Thr Leu Asn Leu 
1               5                   10                  15      


Thr Gly Val Pro Gly Gly Arg Ala Gln Pro Glu Ala Ala Gln Gln Glu 
            20                  25                  30          


Ala Val Thr Ala Ala Glu His Pro Gly Leu Asp Asp Phe Leu Arg Gln 
        35                  40                  45              


Val Glu Arg Leu Leu Phe Leu Arg Glu Asn Ile Gln Arg Leu Gln Gly 
    50                  55                  60                  


Asp Gln Gly Glu His Ser Ala Ser Gln Ile Phe Gln Ser Asp Trp Leu 
65                  70                  75                  80  


Ser Lys Arg Gln His Pro Gly Lys Arg Glu Glu Glu Glu Glu Glu Gly 
                85                  90                  95      


Val Glu Glu Glu Glu Glu Glu Glu Gly Gly Ala Val Gly Pro His Lys 
            100                 105                 110         


Arg Gln His Pro Gly Arg Arg Glu Asp Glu Ala Ser Trp Ser Val Asp 
        115                 120                 125             


Val Thr Gln His Lys Arg Gln His Pro Gly Arg Arg Ser Pro Trp Leu 
    130                 135                 140                 


Ala Tyr Ala Val Pro Lys Arg Gln His Pro Gly Arg Arg Leu Ala Asp 
145                 150                 155                 160 


Pro Lys Ala Gln Arg Ser Trp Glu Glu Glu Glu Glu Glu Glu Glu Arg 
                165                 170                 175     


Glu Glu Asp Leu Met Pro Glu Lys Arg Gln His Pro Gly Lys Arg Ala 
            180                 185                 190         


Leu Gly Gly Pro Cys Gly Pro Gln Gly Ala Tyr Gly Gln Ala Gly Leu 
        195                 200                 205             


Leu Leu Gly Leu Leu Asp Asp Leu Ser Arg Ser Gln Gly Ala Glu Glu 
    210                 215                 220                 


Lys Arg Gln His Pro Gly Arg Arg Ala Ala Trp Val Arg Glu Pro Leu 
225                 230                 235                 240 


Glu Glu 
        


<210>  511
<211>  400
<212>  PRT
<213>  Homo sapiens

<400>  511

Met Thr Thr Lys Asn Leu Glu Thr Lys Val Thr Val Thr Ser Ser Pro 
1               5                   10                  15      


Ile Arg Gly Ala Gly Asp Gly Met Glu Thr Glu Glu Pro Pro Lys Ser 
            20                  25                  30          


Val Glu Val Thr Ser Gly Val Gln Ser Arg Lys His His Ser Leu Gln 
        35                  40                  45              


Ser Pro Trp Lys Lys Ala Val Pro Ser Glu Ser Pro Gly Val Leu Gln 
    50                  55                  60                  


Leu Gly Lys Met Leu Thr Glu Lys Ala Met Glu Val Lys Ala Val Arg 
65                  70                  75                  80  


Ile Leu Val Pro Lys Ala Ala Ile Thr His Asp Ile Pro Asn Lys Asn 
                85                  90                  95      


Thr Lys Val Lys Ser Leu Gly His His Lys Gly Glu Phe Leu Gly Gln 
            100                 105                 110         


Ser Glu Gly Val Ile Glu Pro Asn Lys Glu Leu Ser Glu Val Lys Asn 
        115                 120                 125             


Val Leu Glu Lys Leu Lys Asn Ser Glu Arg Arg Leu Leu Gln Asp Lys 
    130                 135                 140                 


Glu Gly Leu Ser Asn Gln Leu Arg Val Gln Thr Glu Val Asn Arg Glu 
145                 150                 155                 160 


Leu Lys Lys Leu Leu Val Ala Ser Val Gly Asp Asp Leu Gln Tyr His 
                165                 170                 175     


Phe Glu Arg Leu Ala Arg Glu Lys Asn Gln Leu Ile Leu Glu Asn Glu 
            180                 185                 190         


Ala Leu Gly Arg Asn Thr Ala Gln Leu Ser Glu Gln Leu Glu Arg Met 
        195                 200                 205             


Ser Ile Gln Cys Asp Val Trp Arg Ser Lys Phe Leu Ala Ser Arg Val 
    210                 215                 220                 


Met Ala Asp Glu Leu Thr Asn Ser Arg Ala Ala Leu Gln Arg Gln Asn 
225                 230                 235                 240 


Arg Asp Ala His Gly Ala Ile Gln Asp Leu Leu Ser Glu Arg Glu Gln 
                245                 250                 255     


Phe Arg Gln Glu Met Ile Ala Thr Gln Lys Leu Leu Glu Glu Leu Leu 
            260                 265                 270         


Val Ser Leu Gln Trp Gly Arg Glu Gln Thr Tyr Ser Pro Ser Val Gln 
        275                 280                 285             


Pro His Ser Thr Ala Glu Leu Ala Leu Thr Asn His Lys Leu Ala Lys 
    290                 295                 300                 


Ala Val Asn Ser His Leu Leu Gly Asn Val Gly Ile Asn Asn Gln Lys 
305                 310                 315                 320 


Lys Ile Pro Ser Thr Val Glu Phe Cys Ser Thr Pro Ala Glu Lys Met 
                325                 330                 335     


Ala Glu Thr Val Leu Arg Ile Leu Asp Pro Val Thr Cys Lys Glu Ser 
            340                 345                 350         


Ser Pro Asp Asn Pro Phe Phe Glu Ser Ser Pro Thr Thr Leu Leu Ala 
        355                 360                 365             


Thr Lys Lys Asn Ile Gly Arg Phe His Pro Tyr Thr Arg Tyr Glu Asn 
    370                 375                 380                 


Ile Thr Phe Asn Cys Cys Asn His Cys Arg Gly Glu Leu Ile Ala Leu 
385                 390                 395                 400 


<210>  512
<211>  131
<212>  PRT
<213>  Homo sapiens

<400>  512

Gln Asp Arg His Met Ile Arg Met Arg Gln Leu Ile Asp Ile Val Asp 
1               5                   10                  15      


Gln Leu Lys Asn Tyr Val Asn Asp Leu Val Pro Glu Phe Leu Pro Ala 
            20                  25                  30          


Pro Glu Asp Val Glu Thr Asn Cys Glu Trp Ser Ala Phe Ser Cys Phe 
        35                  40                  45              


Gln Lys Ala Gln Leu Lys Ser Ala Asn Thr Gly Asn Asn Glu Arg Ile 
    50                  55                  60                  


Ile Asn Val Ser Ile Lys Lys Leu Lys Arg Lys Pro Pro Ser Thr Asn 
65                  70                  75                  80  


Ala Gly Arg Arg Gln Lys His Arg Leu Thr Cys Pro Ser Cys Asp Ser 
                85                  90                  95      


Tyr Glu Lys Lys Pro Pro Lys Glu Phe Leu Glu Arg Phe Lys Ser Leu 
            100                 105                 110         


Leu Gln Lys Met Ile His Gln His Leu Ser Ser Arg Thr His Gly Ser 
        115                 120                 125             


Glu Asp Ser 
    130     


<210>  513
<211>  233
<212>  PRT
<213>  Homo sapiens

<400>  513

Met Glu Leu Pro Thr Lys Pro Gly Thr Phe Asp Leu Gly Leu Ala Thr 
1               5                   10                  15      


Trp Ser Pro Ser Phe Gln Gly Glu Thr His Arg Ala Gln Ala Arg Arg 
            20                  25                  30          


Arg Asp Val Gly Arg Gln Leu Pro Glu Tyr Lys Ala Val Val Val Gly 
        35                  40                  45              


Ala Ser Gly Val Gly Lys Ser Ala Leu Thr Ile Gln Leu Asn His Gln 
    50                  55                  60                  


Cys Phe Val Glu Asp His Asp Pro Thr Ile Gln Asp Ser Tyr Trp Lys 
65                  70                  75                  80  


Glu Leu Thr Leu Asp Ser Gly Asp Cys Ile Leu Asn Val Leu Asp Thr 
                85                  90                  95      


Ala Gly Gln Ala Ile His Arg Ala Leu Arg Asp Gln Cys Leu Ala Val 
            100                 105                 110         


Cys Asp Gly Val Leu Gly Val Phe Ala Leu Asp Asp Pro Ser Ser Leu 
        115                 120                 125             


Ile Gln Leu Gln Gln Ile Trp Ala Thr Trp Gly Pro His Pro Ala Gln 
    130                 135                 140                 


Pro Leu Val Leu Val Gly Asn Lys Cys Asp Leu Val Thr Thr Ala Gly 
145                 150                 155                 160 


Asp Ala His Ala Ala Ala Ala Ala Leu Ala His Ser Trp Gly Ala His 
                165                 170                 175     


Phe Val Glu Thr Ser Ala Lys Thr Arg Gln Gly Val Glu Glu Ala Phe 
            180                 185                 190         


Ser Leu Leu Val His Glu Ile Gln Arg Val Gln Glu Ala Met Ala Lys 
        195                 200                 205             


Glu Pro Met Ala Arg Ser Cys Arg Glu Lys Thr Arg His Gln Lys Ala 
    210                 215                 220                 


Thr Cys His Cys Gly Cys Ser Val Ala 
225                 230             


<210>  514
<211>  595
<212>  PRT
<213>  Homo sapiens

<400>  514

Ala Thr Glu Asn Gly Ala Val Glu Leu Gly Ile Gln Asn Pro Ser Thr 
1               5                   10                  15      


Asp Lys Ala Pro Lys Gly Pro Thr Gly Glu Arg Pro Leu Ala Ala Gly 
            20                  25                  30          


Lys Asp Pro Gly Pro Pro Asp Pro Lys Lys Ala Pro Asp Pro Pro Thr 
        35                  40                  45              


Leu Lys Lys Asp Ala Lys Ala Pro Ala Ser Glu Lys Gly Asp Gly Thr 
    50                  55                  60                  


Leu Ala Gln Pro Ser Thr Ser Ser Gln Gly Pro Lys Gly Glu Gly Asp 
65                  70                  75                  80  


Arg Gly Gly Gly Pro Ala Glu Gly Ser Ala Gly Pro Pro Ala Ala Leu 
                85                  90                  95      


Pro Gln Gln Thr Ala Thr Pro Glu Thr Ser Val Lys Lys Pro Lys Ala 
            100                 105                 110         


Glu Gln Gly Ala Ser Gly Ser Gln Asp Pro Gly Lys Pro Arg Val Gly 
        115                 120                 125             


Lys Lys Ala Ala Glu Gly Gln Ala Ala Ala Arg Arg Gly Ser Pro Ala 
    130                 135                 140                 


Phe Leu His Ser Pro Ser Cys Pro Ala Ile Ile Ser Ser Ser Glu Lys 
145                 150                 155                 160 


Leu Leu Ala Lys Lys Pro Pro Ser Glu Ala Ser Glu Leu Thr Phe Glu 
                165                 170                 175     


Gly Val Pro Met Thr His Ser Pro Thr Asp Pro Arg Pro Ala Lys Ala 
            180                 185                 190         


Glu Glu Gly Lys Asn Ile Leu Ala Glu Ser Gln Lys Glu Val Gly Glu 
        195                 200                 205             


Lys Thr Pro Gly Gln Ala Gly Gln Ala Lys Met Gln Gly Asp Thr Ser 
    210                 215                 220                 


Arg Gly Ile Glu Phe Gln Ala Val Pro Ser Glu Lys Ser Glu Val Gly 
225                 230                 235                 240 


Gln Ala Leu Cys Leu Thr Ala Arg Glu Glu Asp Cys Phe Gln Ile Leu 
                245                 250                 255     


Asp Asp Cys Pro Pro Pro Pro Ala Pro Phe Pro His Arg Met Val Glu 
            260                 265                 270         


Leu Arg Thr Gly Asn Val Ser Ser Glu Phe Ser Met Asn Ser Lys Glu 
        275                 280                 285             


Ala Leu Gly Gly Gly Lys Phe Gly Ala Val Cys Thr Cys Met Glu Lys 
    290                 295                 300                 


Ala Thr Gly Leu Lys Leu Ala Ala Lys Val Ile Lys Lys Gln Thr Pro 
305                 310                 315                 320 


Lys Asp Lys Glu Met Val Leu Leu Glu Ile Glu Val Met Asn Gln Leu 
                325                 330                 335     


Asn His Arg Asn Leu Ile Gln Leu Tyr Ala Ala Ile Glu Thr Pro His 
            340                 345                 350         


Glu Ile Val Leu Phe Met Glu Tyr Ile Glu Gly Gly Glu Leu Phe Glu 
        355                 360                 365             


Arg Ile Val Asp Glu Asp Tyr His Leu Thr Glu Val Asp Thr Met Val 
    370                 375                 380                 


Phe Val Arg Gln Ile Cys Asp Gly Ile Leu Phe Met His Lys Met Arg 
385                 390                 395                 400 


Val Leu His Leu Asp Leu Lys Pro Glu Asn Ile Leu Cys Val Asn Thr 
                405                 410                 415     


Thr Gly His Leu Val Lys Ile Ile Asp Phe Gly Leu Ala Arg Arg Tyr 
            420                 425                 430         


Asn Pro Asn Glu Lys Leu Lys Val Asn Phe Gly Thr Pro Glu Phe Leu 
        435                 440                 445             


Ser Pro Glu Val Val Asn Tyr Asp Gln Ile Ser Asp Lys Thr Asp Met 
    450                 455                 460                 


Trp Ser Met Gly Val Ile Thr Tyr Met Leu Leu Ser Gly Leu Ser Pro 
465                 470                 475                 480 


Phe Leu Gly Asp Asp Asp Thr Glu Thr Leu Asn Asn Val Leu Ser Gly 
                485                 490                 495     


Asn Trp Tyr Phe Asp Glu Glu Thr Phe Glu Ala Val Ser Asp Glu Ala 
            500                 505                 510         


Lys Asp Phe Val Ser Asn Leu Ile Val Lys Asp Gln Arg Ala Arg Met 
        515                 520                 525             


Asn Ala Ala Gln Cys Leu Ala His Pro Trp Leu Asn Asn Leu Ala Glu 
    530                 535                 540                 


Lys Ala Lys Arg Cys Asn Arg Arg Leu Lys Ser Gln Ile Leu Leu Lys 
545                 550                 555                 560 


Lys Tyr Leu Met Lys Arg Arg Trp Lys Lys Asn Phe Ile Ala Val Ser 
                565                 570                 575     


Ala Ala Asn Arg Phe Lys Lys Ile Ser Ser Ser Gly Ala Leu Met Ala 
            580                 585                 590         


Leu Gly Val 
        595 


<210>  515
<211>  466
<212>  PRT
<213>  Homo sapiens

<400>  515

Met Ala Asp Gln Leu Tyr Leu Glu Asn Ile Asp Glu Phe Val Thr Asp 
1               5                   10                  15      


Gln Asn Lys Ile Val Thr Tyr Lys Trp Leu Ser Tyr Thr Leu Gly Val 
            20                  25                  30          


His Val Asn Gln Ala Lys Gln Met Leu Tyr Asp Tyr Val Glu Arg Lys 
        35                  40                  45              


Arg Lys Glu Asn Ser Gly Ala Gln Leu His Val Thr Tyr Leu Val Ser 
    50                  55                  60                  


Gly Ser Leu Ile Gln Asn Gly His Ser Cys His Lys Val Ala Val Val 
65                  70                  75                  80  


Arg Glu Asp Lys Leu Glu Ala Val Lys Ser Lys Leu Ala Val Thr Ala 
                85                  90                  95      


Ser Ile His Val Tyr Ser Ile Gln Lys Ala Met Leu Lys Asp Ser Gly 
            100                 105                 110         


Pro Leu Phe Asn Thr Asp Tyr Asp Ile Leu Lys Ser Asn Leu Gln Asn 
        115                 120                 125             


Cys Ser Lys Phe Ser Ala Ile Gln Cys Ala Ala Ala Val Pro Arg Ala 
    130                 135                 140                 


Pro Ala Glu Ser Ser Ser Ser Ser Lys Lys Phe Glu Gln Ser His Leu 
145                 150                 155                 160 


His Met Ser Ser Glu Thr Gln Ala Asn Asn Glu Leu Thr Thr Asn Gly 
                165                 170                 175     


His Gly Pro Pro Ala Ser Lys Gln Val Ser Gln Gln Pro Lys Gly Ile 
            180                 185                 190         


Met Gly Met Phe Ala Ser Lys Ala Ala Ala Lys Thr Gln Glu Thr Asn 
        195                 200                 205             


Lys Glu Thr Lys Thr Glu Ala Lys Glu Val Thr Asn Ala Ser Ala Ala 
    210                 215                 220                 


Gly Asn Lys Ala Pro Gly Lys Gly Asn Met Met Ser Asn Phe Phe Gly 
225                 230                 235                 240 


Lys Ala Ala Met Asn Lys Phe Lys Val Asn Leu Asp Ser Glu Gln Ala 
                245                 250                 255     


Val Lys Glu Glu Lys Ile Val Glu Gln Pro Thr Val Ser Val Thr Glu 
            260                 265                 270         


Pro Lys Leu Ala Thr Pro Ala Gly Leu Lys Lys Ser Ser Lys Lys Ala 
        275                 280                 285             


Glu Pro Val Lys Val Leu Gln Lys Glu Lys Lys Arg Gly Lys Arg Val 
    290                 295                 300                 


Ala Leu Ser Asp Asp Glu Thr Lys Glu Thr Glu Asn Met Arg Lys Lys 
305                 310                 315                 320 


Arg Arg Arg Ile Lys Leu Pro Glu Ser Asp Ser Ser Glu Asp Glu Val 
                325                 330                 335     


Phe Pro Asp Ser Pro Gly Ala Tyr Glu Ala Glu Ser Pro Ser Pro Pro 
            340                 345                 350         


Pro Pro Pro Ser Pro Pro Leu Glu Pro Val Pro Lys Thr Glu Pro Glu 
        355                 360                 365             


Pro Pro Ser Val Lys Ser Ser Ser Gly Glu Asn Lys Arg Lys Arg Lys 
    370                 375                 380                 


Arg Val Leu Lys Ser Lys Thr Tyr Leu Asp Gly Glu Gly Cys Ile Val 
385                 390                 395                 400 


Thr Glu Lys Val Tyr Glu Ser Glu Ser Cys Thr Asp Ser Glu Glu Glu 
                405                 410                 415     


Leu Asn Met Lys Thr Ser Ser Val His Arg Pro Pro Ala Met Thr Val 
            420                 425                 430         


Lys Lys Glu Pro Arg Glu Glu Arg Lys Gly Pro Lys Lys Gly Thr Ala 
        435                 440                 445             


Ala Leu Gly Lys Ala Asn Arg Gln Val Ser Ile Thr Gly Phe Phe Gln 
    450                 455                 460                 


Arg Lys 
465     


<210>  516
<211>  345
<212>  PRT
<213>  Homo sapiens

<400>  516

Met Glu Glu Met Ser Leu Ser Gly Leu Asp Asn Ser Lys Leu Glu Ala 
1               5                   10                  15      


Ile Ala Gln Glu Ile Tyr Ala Asp Leu Val Glu Asp Ser Cys Leu Gly 
            20                  25                  30          


Phe Cys Phe Glu Val His Arg Ala Val Lys Cys Gly Tyr Phe Phe Leu 
        35                  40                  45              


Asp Asp Thr Asp Pro Asp Ser Met Lys Asp Phe Glu Ile Val Asp Gln 
    50                  55                  60                  


Pro Gly Leu Asp Ile Phe Gly Gln Val Phe Asn Gln Trp Lys Ser Lys 
65                  70                  75                  80  


Glu Cys Val Cys Pro Asn Cys Ser Arg Ser Ile Ala Ala Ser Arg Phe 
                85                  90                  95      


Ala Pro His Leu Glu Lys Cys Leu Gly Met Gly Arg Asn Ser Ser Arg 
            100                 105                 110         


Ile Ala Asn Arg Arg Ile Ala Asn Ser Asn Asn Met Asn Lys Ser Glu 
        115                 120                 125             


Ser Asp Gln Glu Asp Asn Asp Asp Ile Asn Asp Asn Asp Trp Ser Tyr 
    130                 135                 140                 


Gly Ser Glu Lys Lys Ala Lys Lys Arg Lys Ser Asp Lys Asn Pro Asn 
145                 150                 155                 160 


Ser Pro Arg Arg Ser Lys Ser Leu Lys His Lys Asn Gly Glu Leu Ser 
                165                 170                 175     


Asn Ser Asp Pro Phe Lys Tyr Asn Asn Ser Thr Gly Ile Ser Tyr Glu 
            180                 185                 190         


Thr Leu Gly Pro Glu Glu Leu Arg Ser Leu Leu Thr Thr Gln Cys Gly 
        195                 200                 205             


Val Ile Ser Glu His Thr Lys Lys Met Cys Thr Arg Ser Leu Arg Cys 
    210                 215                 220                 


Pro Gln His Thr Asp Glu Gln Arg Arg Thr Val Arg Ile Tyr Phe Leu 
225                 230                 235                 240 


Gly Pro Ser Ala Val Leu Pro Glu Val Glu Ser Ser Leu Asp Asn Asp 
                245                 250                 255     


Ser Phe Asp Met Thr Asp Ser Gln Ala Leu Ile Ser Arg Leu Gln Trp 
            260                 265                 270         


Asp Gly Ser Ser Asp Leu Ser Pro Ser Asp Ser Gly Ser Ser Lys Thr 
        275                 280                 285             


Ser Glu Asn Gln Gly Trp Gly Leu Gly Thr Asn Ser Ser Glu Ser Arg 
    290                 295                 300                 


Lys Thr Lys Lys Lys Lys Ser His Leu Ser Leu Val Gly Thr Ala Ser 
305                 310                 315                 320 


Gly Leu Gly Ser Asn Lys Lys Lys Lys Pro Lys Pro Pro Ala Pro Pro 
                325                 330                 335     


Thr Pro Ser Ile Tyr Asp Asp Ile Asn 
            340                 345 


<210>  517
<211>  227
<212>  PRT
<213>  Homo sapiens

<400>  517

Met Thr Asp Phe Lys Leu Gly Ile Val Arg Leu Gly Arg Val Ala Gly 
1               5                   10                  15      


Lys Thr Lys Tyr Thr Leu Ile Asp Glu Gln Asp Ile Pro Leu Val Glu 
            20                  25                  30          


Ser Tyr Ser Phe Glu Ala Arg Met Glu Val Asp Ala Asp Gly Asn Gly 
        35                  40                  45              


Ala Lys Ile Phe Ala Tyr Ala Phe Asp Lys Asn Arg Gly Arg Gly Ser 
    50                  55                  60                  


Gly Arg Leu Leu His Glu Leu Leu Trp Glu Arg His Arg Gly Gly Val 
65                  70                  75                  80  


Ala Pro Gly Phe Gln Val Val His Leu Asn Ala Val Thr Val Asp Asn 
                85                  90                  95      


Arg Leu Asp Asn Leu Gln Leu Val Pro Trp Gly Trp Arg Pro Lys Ala 
            100                 105                 110         


Glu Glu Thr Ser Ser Lys Gln Arg Glu Gln Ser Leu Tyr Trp Leu Ala 
        115                 120                 125             


Ile Gln Gln Leu Pro Thr Asp Pro Ile Glu Glu Gln Phe Pro Val Leu 
    130                 135                 140                 


Asn Val Thr Arg Tyr Tyr Asn Ala Asn Gly Asp Val Val Glu Glu Glu 
145                 150                 155                 160 


Glu Asn Ser Cys Thr Tyr Tyr Glu Cys His Tyr Pro Pro Cys Thr Val 
                165                 170                 175     


Ile Glu Lys Gln Leu Arg Glu Phe Asn Ile Cys Gly Arg Cys Gln Val 
            180                 185                 190         


Ala Arg Tyr Cys Gly Ser Gln Cys Gln Gln Lys Asp Trp Pro Ala His 
        195                 200                 205             


Lys Lys His Cys Arg Glu Arg Lys Arg Pro Phe Gln His Glu Leu Glu 
    210                 215                 220                 


Pro Glu Arg 
225         


<210>  518
<211>  113
<212>  PRT
<213>  Homo sapiens

<400>  518

Met Leu Leu His Tyr Thr Phe Gln Gln Pro Arg His Gln Ser Ser Val 
1               5                   10                  15      


Lys Leu Arg Glu Gln Ile Leu Asp Leu Ser Lys Arg Tyr Val Lys Ala 
            20                  25                  30          


Leu Ala Glu Glu Asn Lys Asn Thr Val Asp Val Glu Asn Gly Ala Ser 
        35                  40                  45              


Met Ala Gly Tyr Ala Asp Leu Lys Arg Thr Ile Ala Val Leu Leu Asp 
    50                  55                  60                  


Asp Ile Leu Gln Arg Leu Val Lys Leu Glu Asn Lys Val Asp Tyr Ile 
65                  70                  75                  80  


Val Val Asn Gly Ser Ala Ala Asn Thr Thr Asn Gly Thr Ser Gly Asn 
                85                  90                  95      


Leu Val Pro Val Thr Thr Asn Lys Arg Thr Asn Val Ser Gly Ser Ile 
            100                 105                 110         


Arg 
    


<210>  519
<211>  612
<212>  PRT
<213>  Homo sapiens

<400>  519

Met Ile Lys Asn Glu Val Asp Met Gln Val Leu His Leu Leu Gly Pro 
1               5                   10                  15      


Lys Leu Glu Ala Asp Leu Glu Lys Lys Phe Lys Val Ala Lys Ala Arg 
            20                  25                  30          


Leu Glu Glu Thr Asp Arg Arg Thr Ala Lys Asp Val Val Glu Asn Gly 
        35                  40                  45              


Glu Thr Ala Asp Gln Thr Leu Ser Leu Met Glu Gln Leu Arg Gly Glu 
    50                  55                  60                  


Ala Leu Lys Phe His Lys Pro Gly Glu Asn Tyr Lys Thr Pro Gly Tyr 
65                  70                  75                  80  


Val Val Thr Pro His Thr Met Asn Leu Leu Lys Gln His Leu Glu Ile 
                85                  90                  95      


Thr Gly Gly Gln Val Arg Thr Arg Phe Pro Pro Glu Pro Asn Gly Ile 
            100                 105                 110         


Leu His Ile Gly His Ala Lys Ala Ile Asn Phe Asn Phe Gly Tyr Ala 
        115                 120                 125             


Lys Ala Asn Asn Gly Ile Cys Phe Leu Arg Phe Asp Asp Thr Asn Pro 
    130                 135                 140                 


Glu Lys Glu Glu Ala Lys Phe Phe Thr Ala Ile Cys Asp Met Val Ala 
145                 150                 155                 160 


Trp Leu Gly Tyr Thr Pro Tyr Lys Val Thr Tyr Ala Ser Asp Tyr Phe 
                165                 170                 175     


Asp Gln Leu Tyr Ala Trp Ala Val Glu Leu Ile Arg Arg Gly Leu Ala 
            180                 185                 190         


Tyr Val Cys His Gln Arg Gly Glu Glu Leu Lys Gly His Asn Thr Leu 
        195                 200                 205             


Pro Ser Pro Trp Arg Asp Arg Pro Met Glu Glu Ser Leu Leu Leu Phe 
    210                 215                 220                 


Glu Ala Met Arg Lys Gly Lys Phe Ser Glu Gly Glu Ala Thr Leu Arg 
225                 230                 235                 240 


Met Lys Leu Val Met Glu Asp Gly Lys Met Asp Pro Val Ala Tyr Arg 
                245                 250                 255     


Val Lys Tyr Thr Pro His His Arg Thr Gly Asp Lys Trp Cys Ile Tyr 
            260                 265                 270         


Pro Thr Tyr Asp Tyr Thr His Cys Leu Cys Asp Ser Ile Glu His Ile 
        275                 280                 285             


Thr His Ser Leu Cys Thr Lys Glu Phe Gln Ala Arg Arg Ser Ser Tyr 
    290                 295                 300                 


Phe Trp Leu Cys Asn Ala Leu Asp Val Tyr Cys Pro Val Gln Trp Glu 
305                 310                 315                 320 


Tyr Gly Arg Leu Asn Leu His Tyr Ala Val Val Ser Lys Arg Lys Ile 
                325                 330                 335     


Leu Gln Leu Val Ala Thr Gly Ala Val Arg Asp Trp Asp Asp Pro Arg 
            340                 345                 350         


Leu Phe Thr Leu Thr Ala Leu Arg Arg Arg Gly Phe Pro Pro Glu Ala 
        355                 360                 365             


Ile Asn Asn Phe Cys Ala Arg Val Gly Val Thr Val Ala Gln Thr Thr 
    370                 375                 380                 


Met Glu Pro His Leu Leu Glu Ala Cys Val Arg Asp Val Leu Asn Asp 
385                 390                 395                 400 


Thr Ala Pro Arg Ala Met Ala Val Leu Glu Ser Leu Arg Val Ile Ile 
                405                 410                 415     


Thr Asn Phe Pro Ala Ala Lys Ser Leu Asp Ile Gln Val Pro Asn Phe 
            420                 425                 430         


Pro Ala Asp Glu Thr Lys Gly Phe His Gln Val Pro Phe Ala Pro Ile 
        435                 440                 445             


Val Phe Ile Glu Arg Thr Asp Phe Lys Glu Glu Pro Glu Pro Gly Phe 
    450                 455                 460                 


Lys Arg Leu Ala Trp Gly Gln Pro Val Gly Leu Arg His Thr Gly Tyr 
465                 470                 475                 480 


Val Ile Glu Leu Gln His Val Val Lys Gly Pro Ser Gly Cys Val Glu 
                485                 490                 495     


Ser Leu Glu Val Thr Cys Arg Arg Ala Asp Ala Gly Glu Lys Pro Lys 
            500                 505                 510         


Ala Phe Ile His Trp Val Ser Gln Pro Leu Met Cys Glu Val Arg Leu 
        515                 520                 525             


Tyr Glu Arg Leu Phe Gln His Lys Asn Pro Glu Asp Pro Thr Glu Val 
    530                 535                 540                 


Pro Gly Gly Phe Leu Ser Asp Leu Asn Leu Ala Ser Leu His Val Val 
545                 550                 555                 560 


Asp Ala Ala Leu Val Asp Cys Ser Val Ala Leu Ala Lys Pro Phe Asp 
                565                 570                 575     


Lys Phe Gln Phe Glu Arg Leu Gly Tyr Phe Ser Val Asp Pro Asp Ser 
            580                 585                 590         


His Gln Gly Lys Leu Val Phe Asn Arg Thr Val Thr Leu Lys Glu Asp 
        595                 600                 605             


Pro Gly Lys Val 
    610         


<210>  520
<211>  391
<212>  PRT
<213>  Homo sapiens

<400>  520

Met Glu Pro Leu Arg Val Leu Glu Leu Tyr Ser Gly Val Gly Gly Met 
1               5                   10                  15      


His His Ala Leu Arg Glu Ser Cys Ile Pro Ala Gln Val Val Ala Ala 
            20                  25                  30          


Ile Asp Val Asn Thr Val Ala Asn Glu Val Tyr Lys Tyr Asn Phe Pro 
        35                  40                  45              


His Thr Gln Leu Leu Ala Lys Thr Ile Glu Gly Ile Thr Leu Glu Glu 
    50                  55                  60                  


Phe Asp Arg Leu Ser Phe Asp Met Ile Leu Met Ser Pro Pro Cys Gln 
65                  70                  75                  80  


Pro Phe Thr Arg Ile Gly Arg Gln Gly Asp Met Thr Asp Ser Arg Thr 
                85                  90                  95      


Asn Ser Phe Leu Tyr Ile Leu Asp Ile Leu Pro Arg Leu Gln Lys Leu 
            100                 105                 110         


Pro Lys Tyr Ile Leu Leu Glu Asn Val Lys Gly Phe Glu Val Ser Ser 
        115                 120                 125             


Thr Arg Asp Leu Leu Ile Gln Thr Ile Glu Asn Cys Gly Phe Gln Tyr 
    130                 135                 140                 


Gln Glu Phe Leu Leu Ser Pro Thr Ser Leu Gly Ile Pro Asn Ser Arg 
145                 150                 155                 160 


Leu Arg Tyr Phe Leu Ile Ala Lys Leu Gln Ser Glu Pro Leu Pro Phe 
                165                 170                 175     


Gln Ala Pro Gly Gln Val Leu Met Glu Phe Pro Lys Ile Glu Ser Val 
            180                 185                 190         


His Pro Gln Lys Tyr Ala Met Asp Val Glu Asn Lys Ile Gln Glu Lys 
        195                 200                 205             


Asn Val Glu Pro Asn Ile Ser Phe Asp Gly Ser Ile Gln Cys Ser Gly 
    210                 215                 220                 


Lys Asp Ala Ile Leu Phe Lys Leu Glu Thr Ala Glu Glu Ile His Arg 
225                 230                 235                 240 


Lys Asn Gln Gln Asp Ser Asp Leu Ser Val Lys Met Leu Lys Asp Phe 
                245                 250                 255     


Leu Glu Asp Asp Thr Asp Val Asn Gln Tyr Leu Leu Pro Pro Lys Ser 
            260                 265                 270         


Leu Leu Arg Tyr Ala Leu Leu Leu Asp Ile Val Gln Pro Thr Cys Arg 
        275                 280                 285             


Arg Ser Val Cys Phe Thr Lys Gly Tyr Gly Ser Tyr Ile Glu Gly Thr 
    290                 295                 300                 


Gly Ser Val Leu Gln Thr Ala Glu Asp Val Gln Val Glu Asn Ile Tyr 
305                 310                 315                 320 


Lys Ser Leu Thr Asn Leu Ser Gln Glu Glu Gln Ile Thr Lys Leu Leu 
                325                 330                 335     


Ile Leu Lys Leu Arg Tyr Phe Thr Pro Lys Glu Ile Ala Asn Leu Leu 
            340                 345                 350         


Gly Phe Pro Pro Glu Phe Gly Phe Pro Glu Lys Ile Thr Val Lys Gln 
        355                 360                 365             


Arg Tyr Arg Leu Leu Gly Asn Ser Leu Asn Val His Val Val Ala Lys 
    370                 375                 380                 


Leu Ile Lys Ile Leu Tyr Glu 
385                 390     


<210>  521
<211>  395
<212>  PRT
<213>  Homo sapiens

<400>  521

Met Asp Leu Gly Ile Pro Asp Leu Leu Asp Ala Trp Leu Glu Pro Pro 
1               5                   10                  15      


Glu Asp Ile Phe Ser Thr Gly Ser Val Leu Glu Leu Gly Leu His Cys 
            20                  25                  30          


Pro Pro Pro Glu Val Pro Val Thr Arg Leu Gln Glu Gln Gly Leu Gln 
        35                  40                  45              


Gly Trp Lys Ser Gly Gly Asp Arg Gly Cys Gly Leu Gln Glu Ser Glu 
    50                  55                  60                  


Pro Glu Asp Phe Leu Lys Leu Phe Ile Asp Pro Asn Glu Val Tyr Cys 
65                  70                  75                  80  


Ser Glu Ala Ser Pro Gly Ser Asp Ser Gly Ile Ser Glu Asp Pro Cys 
                85                  90                  95      


His Pro Asp Ser Pro Pro Ala Pro Arg Ala Thr Ser Ser Pro Met Leu 
            100                 105                 110         


Tyr Glu Val Val Tyr Glu Ala Gly Ala Leu Glu Arg Met Gln Gly Glu 
        115                 120                 125             


Thr Gly Pro Asn Val Gly Leu Ile Ser Ile Gln Leu Asp Gln Trp Ser 
    130                 135                 140                 


Pro Ala Phe Met Val Pro Asp Ser Cys Met Val Ser Glu Leu Pro Phe 
145                 150                 155                 160 


Asp Ala His Ala His Ile Leu Pro Arg Ala Gly Thr Val Ala Pro Val 
                165                 170                 175     


Pro Cys Thr Thr Leu Leu Pro Cys Gln Thr Leu Phe Leu Thr Asp Glu 
            180                 185                 190         


Glu Lys Arg Leu Leu Gly Gln Glu Gly Val Ser Leu Pro Ser His Leu 
        195                 200                 205             


Pro Leu Thr Lys Ala Glu Glu Arg Val Leu Lys Lys Val Arg Arg Lys 
    210                 215                 220                 


Ile Arg Asn Lys Gln Ser Ala Gln Asp Ser Arg Arg Arg Lys Lys Glu 
225                 230                 235                 240 


Tyr Ile Asp Gly Leu Glu Ser Arg Val Ala Ala Cys Ser Ala Gln Asn 
                245                 250                 255     


Gln Glu Leu Gln Lys Lys Val Gln Glu Leu Glu Arg His Asn Ile Ser 
            260                 265                 270         


Leu Val Ala Gln Leu Arg Gln Leu Gln Thr Leu Ile Ala Gln Thr Ser 
        275                 280                 285             


Asn Lys Ala Ala Gln Thr Ser Thr Cys Val Leu Ile Leu Leu Phe Ser 
    290                 295                 300                 


Leu Ala Leu Ile Ile Leu Pro Ser Phe Ser Pro Phe Gln Ser Arg Pro 
305                 310                 315                 320 


Glu Ala Gly Ser Glu Asp Tyr Gln Pro His Gly Val Thr Ser Arg Asn 
                325                 330                 335     


Ile Leu Thr His Lys Asp Val Thr Glu Asn Leu Glu Thr Gln Val Val 
            340                 345                 350         


Glu Ser Arg Leu Arg Glu Pro Pro Gly Ala Lys Asp Ala Asn Gly Ser 
        355                 360                 365             


Thr Arg Thr Leu Leu Glu Lys Met Gly Gly Lys Pro Arg Pro Ser Gly 
    370                 375                 380                 


Arg Ile Arg Ser Val Leu His Ala Asp Glu Met 
385                 390                 395 


<210>  522
<211>  236
<212>  PRT
<213>  Homo sapiens

<400>  522

Met Ala Ser Leu Asp Arg Val Lys Val Leu Val Leu Gly Asp Ser Gly 
1               5                   10                  15      


Val Gly Lys Ser Ser Leu Val His Leu Leu Cys Gln Asn Gln Val Leu 
            20                  25                  30          


Gly Asn Pro Ser Trp Thr Val Gly Cys Ser Val Asp Val Arg Val His 
        35                  40                  45              


Asp Tyr Lys Glu Gly Thr Pro Glu Glu Lys Thr Cys Tyr Ile Glu Leu 
    50                  55                  60                  


Trp Asp Val Gly Gly Ser Val Gly Ser Ala Ser Ser Val Lys Ser Thr 
65                  70                  75                  80  


Arg Ala Val Phe Tyr Asn Ser Val Asn Gly Ile Ile Phe Val His Asp 
                85                  90                  95      


Leu Thr Asn Lys Lys Ser Ser Gln Asn Leu Arg Arg Trp Ser Leu Glu 
            100                 105                 110         


Ala Leu Asn Arg Asp Leu Val Pro Thr Gly Val Leu Val Thr Asn Gly 
        115                 120                 125             


Asp Tyr Asp Gln Glu Gln Phe Ala Asp Asn Gln Ile Pro Leu Leu Val 
    130                 135                 140                 


Ile Gly Thr Lys Leu Asp Gln Ile His Glu Thr Lys Arg His Glu Val 
145                 150                 155                 160 


Leu Thr Thr Thr Ala Phe Leu Ala Glu Asp Phe Asn Pro Glu Glu Ile 
                165                 170                 175     


Asn Leu Asp Cys Thr Asn Pro Arg Tyr Leu Ala Ala Gly Ser Ser Asn 
            180                 185                 190         


Ala Val Lys Leu Ser Arg Phe Phe Asp Lys Val Ile Glu Lys Arg Tyr 
        195                 200                 205             


Phe Leu Arg Glu Gly Asn Gln Ile Pro Gly Phe Pro Asp Arg Lys Arg 
    210                 215                 220                 


Phe Gly Ala Gly Thr Leu Lys Ser Leu His Tyr Asp 
225                 230                 235     


<210>  523
<211>  527
<212>  PRT
<213>  Homo sapiens

<400>  523

Met Ser Glu Asp Ser Ser Ala Leu Pro Trp Ser Ile Asn Arg Asp Asp 
1               5                   10                  15      


Tyr Glu Leu Gln Glu Val Ile Gly Ser Gly Ala Thr Ala Val Val Gln 
            20                  25                  30          


Ala Ala Tyr Cys Ala Pro Lys Lys Glu Lys Val Ala Ile Lys Arg Ile 
        35                  40                  45              


Asn Leu Glu Lys Cys Gln Thr Ser Met Asp Glu Leu Leu Lys Glu Ile 
    50                  55                  60                  


Gln Ala Met Ser Gln Cys His His Pro Asn Ile Val Ser Tyr Tyr Thr 
65                  70                  75                  80  


Ser Phe Val Val Lys Asp Glu Leu Trp Leu Val Met Lys Leu Leu Ser 
                85                  90                  95      


Gly Gly Ser Val Leu Asp Ile Ile Lys His Ile Val Ala Lys Gly Glu 
            100                 105                 110         


His Lys Ser Gly Val Leu Asp Glu Ser Thr Ile Ala Thr Ile Leu Arg 
        115                 120                 125             


Glu Val Leu Glu Gly Leu Glu Tyr Leu His Lys Asn Gly Gln Ile His 
    130                 135                 140                 


Arg Asp Val Lys Ala Gly Asn Ile Leu Leu Gly Glu Asp Gly Ser Val 
145                 150                 155                 160 


Gln Ile Ala Asp Phe Gly Val Ser Ala Phe Leu Ala Thr Gly Gly Asp 
                165                 170                 175     


Ile Thr Arg Asn Lys Val Arg Lys Thr Phe Val Gly Thr Pro Cys Trp 
            180                 185                 190         


Met Ala Pro Glu Val Met Glu Gln Val Arg Gly Tyr Asp Phe Lys Ala 
        195                 200                 205             


Asp Ile Trp Ser Phe Gly Ile Thr Ala Ile Glu Leu Ala Thr Gly Ala 
    210                 215                 220                 


Ala Pro Tyr His Lys Tyr Pro Pro Met Lys Val Leu Met Leu Thr Leu 
225                 230                 235                 240 


Gln Asn Asp Pro Pro Ser Leu Glu Thr Gly Val Gln Asp Lys Glu Met 
                245                 250                 255     


Leu Lys Lys Tyr Gly Lys Ser Phe Arg Lys Met Ile Ser Leu Cys Leu 
            260                 265                 270         


Gln Lys Asp Pro Glu Lys Arg Pro Thr Ala Ala Glu Leu Leu Arg His 
        275                 280                 285             


Lys Phe Phe Gln Lys Ala Lys Asn Lys Glu Phe Leu Gln Glu Lys Thr 
    290                 295                 300                 


Leu Gln Arg Ala Pro Thr Ile Ser Glu Arg Ala Lys Lys Val Arg Arg 
305                 310                 315                 320 


Val Pro Gly Ser Ser Gly Arg Leu His Lys Thr Glu Asp Gly Gly Trp 
                325                 330                 335     


Glu Trp Ser Asp Asp Glu Phe Asp Glu Glu Ser Glu Glu Gly Lys Ala 
            340                 345                 350         


Ala Ile Ser Gln Leu Arg Ser Pro Arg Val Lys Glu Ser Ile Ser Asn 
        355                 360                 365             


Ser Glu Leu Phe Pro Thr Thr Asp Pro Val Gly Thr Leu Leu Gln Val 
    370                 375                 380                 


Pro Glu Gln Ile Ser Ala His Leu Pro Gln Pro Ala Gly Gln Ile Ala 
385                 390                 395                 400 


Thr Gln Pro Thr Gln Val Ser Leu Pro Pro Thr Ala Glu Pro Ala Lys 
                405                 410                 415     


Thr Ala Gln Ala Leu Ser Ser Gly Ser Gly Ser Gln Glu Thr Lys Ile 
            420                 425                 430         


Pro Ile Ser Leu Val Leu Arg Leu Arg Asn Ser Lys Lys Glu Leu Asn 
        435                 440                 445             


Asp Ile Arg Phe Glu Phe Thr Pro Gly Arg Asp Thr Ala Glu Gly Val 
    450                 455                 460                 


Ser Gln Glu Leu Ile Ser Ala Gly Leu Val Asp Gly Arg Asp Leu Val 
465                 470                 475                 480 


Ile Val Ala Ala Asn Leu Gln Lys Ile Val Glu Glu Pro Gln Ser Asn 
                485                 490                 495     


Arg Ser Val Thr Phe Lys Leu Ala Ser Gly Val Glu Gly Ser Asp Ile 
            500                 505                 510         


Pro Asp Asp Gly Lys Leu Ile Gly Phe Ala Gln Leu Ser Ile Ser 
        515                 520                 525         


<210>  524
<211>  395
<212>  PRT
<213>  Homo sapiens

<400>  524

Met Ala Glu Asp Gly Leu Pro Lys Ile Tyr Ser His Pro Pro Thr Glu 
1               5                   10                  15      


Ser Ser Lys Thr Pro Thr Ala Ala Thr Ile Phe Phe Gly Ala Asp Asn 
            20                  25                  30          


Ala Ile Pro Lys Ser Glu Thr Thr Ile Thr Ser Glu Gly Asp His Val 
        35                  40                  45              


Thr Ser Val Asn Glu Tyr Met Leu Glu Ser Asp Phe Ser Thr Thr Thr 
    50                  55                  60                  


Asp Asn Lys Leu Thr Ala Lys Lys Glu Lys Leu Lys Ser Glu Asp Asp 
65                  70                  75                  80  


Met Gly Thr Asp Phe Ile Lys Ser Thr Thr His Leu Gln Lys Glu Ile 
                85                  90                  95      


Thr Ser Leu Thr Gly Thr Thr Asn Ser Ile Thr Arg Asp Ser Ile Thr 
            100                 105                 110         


Glu His Phe Met Pro Val Lys Ile Gly Asn Ile Ser Ser Pro Val Thr 
        115                 120                 125             


Thr Val Ser Leu Ile Asp Phe Ser Thr Asp Ile Ala Lys Glu Asp Ile 
    130                 135                 140                 


Leu Leu Ala Thr Ile Asp Thr Gly Asp Ala Glu Ile Ser Ile Thr Ser 
145                 150                 155                 160 


Glu Val Ser Gly Thr Leu Lys Asp Ser Ser Ala Gly Val Ala Asp Ala 
                165                 170                 175     


Pro Ala Phe Pro Arg Lys Lys Asp Glu Ala Asp Met Ser Asn Tyr Asn 
            180                 185                 190         


Ser Ser Ile Lys Ser Asn Val Pro Ala Asp Glu Ala Val Gln Val Thr 
        195                 200                 205             


Asp Ser Ile Ile Pro Glu Ala Glu Ile Pro Pro Ala Pro Glu Glu Ser 
    210                 215                 220                 


Phe Thr Thr Ile Pro Asp Ile Thr Ala Leu Glu Glu Glu Lys Ile Thr 
225                 230                 235                 240 


Glu Ile Asp Leu Ser Val Leu Glu Asp Asp Thr Ser Ala Val Ala Thr 
                245                 250                 255     


Leu Thr Asp Ser Asp Glu Lys Phe Ile Thr Val Phe Glu Leu Thr Thr 
            260                 265                 270         


Ser Ala Glu Lys Asp Lys Asp Lys Arg Glu Asp Thr Leu Leu Thr Asp 
        275                 280                 285             


Glu Glu Thr Thr Glu Gly Ala Ser Ile Gly Met Glu Arg Asp Thr Ala 
    290                 295                 300                 


Asn Glu Ala Glu Thr His Ser Val Leu Leu Thr Ala Val Glu Ser Arg 
305                 310                 315                 320 


Tyr Asp Phe Val Val Pro Ala Ser Ile Ala Thr Asn Leu Val Glu Glu 
                325                 330                 335     


Ser Ser Thr Glu Glu Asp Leu Ser Glu Thr Asp Asn Thr Glu Thr Val 
            340                 345                 350         


Pro Lys Ile Thr Glu Pro Phe Ser Gly Thr Thr Ser Val Leu Asp Thr 
        355                 360                 365             


Pro Asp Tyr Lys Glu Asp Thr Ser Thr Thr Glu Thr Asp Ile Phe Glu 
    370                 375                 380                 


Leu Leu Lys Glu Glu Pro Asp Glu Phe Met Ile 
385                 390                 395 


<210>  525
<211>  256
<212>  PRT
<213>  Homo sapiens

<400>  525

Met Ala Ala Val Lys Ser Thr Glu Ala His Pro Ser Ser Asn Lys Asp 
1               5                   10                  15      


Pro Thr Gln Gly Gln Lys Ser Ala Leu Gln Gly Asn Ser Pro Asp Ser 
            20                  25                  30          


Glu Ala Ser Arg Gln Arg Phe Arg Gln Phe Cys Tyr Gln Glu Val Thr 
        35                  40                  45              


Gly Pro His Glu Ala Phe Ser Lys Leu Trp Glu Leu Cys Cys Gln Trp 
    50                  55                  60                  


Leu Arg Pro Lys Thr His Ser Lys Glu Glu Ile Leu Glu Leu Leu Val 
65                  70                  75                  80  


Leu Glu Gln Phe Leu Thr Ile Leu Pro Glu Glu Ile Gln Thr Trp Val 
                85                  90                  95      


Arg Glu Gln His Pro Glu Asn Gly Glu Glu Ala Val Ala Leu Val Glu 
            100                 105                 110         


Asp Val Gln Arg Ala Pro Gly Gln Gln Val Leu Asp Ser Glu Lys Asp 
        115                 120                 125             


Leu Lys Val Leu Met Lys Glu Met Ala Pro Leu Gly Ala Thr Arg Glu 
    130                 135                 140                 


Ser Leu Arg Ser Gln Trp Lys Gln Glu Val Gln Pro Glu Glu Pro Thr 
145                 150                 155                 160 


Phe Lys Gly Ser Gln Ser Ser His Gln Arg Pro Gly Glu Gln Ser Glu 
                165                 170                 175     


Ala Trp Leu Ala Pro Gln Ala Pro Arg Asn Leu Pro Gln Asn Thr Gly 
            180                 185                 190         


Leu His Asp Gln Glu Thr Gly Ala Val Val Trp Thr Ala Gly Ser Gln 
        195                 200                 205             


Gly Pro Ala Met Arg Asp Asn Arg Ala Val Ser Leu Cys Gln Gln Glu 
    210                 215                 220                 


Trp Met Cys Pro Gly Pro Ala Gln Arg Ala Leu Tyr Arg Gly Ala Thr 
225                 230                 235                 240 


Gln Arg Lys Asp Ser His Val Ser Leu Ala Thr Gly Ala Leu Gly Leu 
                245                 250                 255     


<210>  526
<211>  471
<212>  PRT
<213>  Homo sapiens

<400>  526

Met Ala Asp Glu Arg Lys Asp Glu Ala Lys Ala Pro His Trp Thr Ser 
1               5                   10                  15      


Ala Pro Leu Thr Glu Ala Ser Ala His Ser His Pro Pro Glu Ile Lys 
            20                  25                  30          


Asp Gln Gly Gly Ala Gly Glu Gly Leu Val Arg Ser Ala Asn Gly Phe 
        35                  40                  45              


Pro Tyr Arg Glu Asp Glu Glu Gly Ala Phe Gly Glu His Gly Ser Gln 
    50                  55                  60                  


Gly Thr Tyr Ser Asn Thr Lys Glu Asn Gly Ile Asn Gly Glu Leu Thr 
65                  70                  75                  80  


Ser Ala Asp Arg Glu Thr Ala Glu Glu Val Ser Ala Arg Ile Val Gln 
                85                  90                  95      


Val Val Thr Ala Glu Ala Val Ala Val Leu Lys Gly Glu Gln Glu Lys 
            100                 105                 110         


Glu Ala Gln His Lys Asp Gln Thr Ala Ala Leu Pro Leu Ala Ala Glu 
        115                 120                 125             


Glu Thr Ala Asn Leu Pro Pro Ser Pro Pro Pro Ser Pro Ala Ser Glu 
    130                 135                 140                 


Gln Thr Val Thr Val Glu Glu Ala Ala Gly Gly Glu Ser Ala Leu Ala 
145                 150                 155                 160 


Pro Ser Val Phe Lys Gln Ala Lys Asp Lys Val Ser Asp Gly Val Thr 
                165                 170                 175     


Lys Ser Pro Glu Lys Arg Ser Ser Leu Pro Arg Pro Ser Ser Ile Leu 
            180                 185                 190         


Pro Pro Arg Arg Gly Val Ser Gly Asp Arg Asp Glu Asn Ser Phe Ser 
        195                 200                 205             


Leu Asn Ser Ser Ile Ser Ser Ser Ala Arg Arg Thr Thr Arg Ser Glu 
    210                 215                 220                 


Pro Ile Arg Arg Ala Gly Lys Ser Gly Thr Ser Thr Pro Thr Thr Pro 
225                 230                 235                 240 


Gly Ser Thr Ala Ile Thr Pro Gly Thr Pro Pro Ser Tyr Ser Ser Arg 
                245                 250                 255     


Thr Pro Gly Thr Pro Gly Thr Pro Ser Tyr Pro Arg Thr Pro His Thr 
            260                 265                 270         


Pro Gly Thr Pro Lys Ser Ala Ile Leu Val Pro Ser Glu Lys Lys Val 
        275                 280                 285             


Ala Ile Ile Arg Thr Pro Pro Lys Ser Pro Ala Thr Pro Lys Gln Leu 
    290                 295                 300                 


Arg Leu Ile Asn Gln Pro Leu Pro Asp Leu Lys Asn Val Lys Ser Lys 
305                 310                 315                 320 


Ile Gly Ser Thr Asp Asn Ile Lys Tyr Gln Pro Lys Gly Gly Gln Val 
                325                 330                 335     


Gln Ile Val Thr Lys Lys Ile Asp Leu Ser His Val Thr Ser Lys Cys 
            340                 345                 350         


Gly Ser Leu Lys Asn Ile Arg His Arg Pro Gly Gly Gly Arg Val Lys 
        355                 360                 365             


Ile Glu Ser Val Lys Leu Asp Phe Lys Glu Lys Ala Gln Ala Lys Val 
    370                 375                 380                 


Gly Ser Leu Asp Asn Ala His His Val Pro Gly Gly Gly Asn Val Lys 
385                 390                 395                 400 


Ile Asp Ser Gln Lys Leu Asn Phe Arg Glu His Ala Lys Ala Arg Val 
                405                 410                 415     


Asp His Gly Ala Glu Ile Ile Thr Gln Ser Pro Gly Arg Ser Ser Val 
            420                 425                 430         


Ala Ser Pro Arg Arg Leu Ser Asn Val Ser Ser Ser Gly Ser Ile Asn 
        435                 440                 445             


Leu Leu Glu Ser Pro Gln Leu Ala Thr Leu Ala Glu Asp Val Thr Ala 
    450                 455                 460                 


Ala Leu Ala Lys Gln Gly Leu 
465                 470     


<210>  527
<211>  206
<212>  PRT
<213>  Homo sapiens

<400>  527

Met Ser Thr Ala Asp Ala Leu Asp Asp Glu Asn Thr Phe Lys Ile Leu 
1               5                   10                  15      


Val Ala Thr Asp Ile His Leu Gly Phe Met Glu Lys Asp Ala Val Arg 
            20                  25                  30          


Gly Asn Asp Thr Phe Val Thr Leu Asp Glu Ile Leu Arg Leu Ala Gln 
        35                  40                  45              


Glu Asn Glu Val Asp Phe Ile Leu Leu Gly Gly Asp Leu Phe His Glu 
    50                  55                  60                  


Asn Lys Pro Ser Arg Lys Thr Leu His Thr Cys Leu Glu Leu Leu Arg 
65                  70                  75                  80  


Lys Tyr Cys Met Gly Asp Arg Pro Val Gln Phe Glu Ile Leu Ser Asp 
                85                  90                  95      


Gln Ser Val Asn Phe Gly Phe Ser Lys Phe Pro Trp Val Asn Tyr Gln 
            100                 105                 110         


Asp Gly Asn Leu Asn Ile Ser Ile Pro Val Phe Ser Ile His Gly Asn 
        115                 120                 125             


His Asp Asp Pro Thr Gly Ala Asp Ala Leu Cys Ala Leu Asp Ile Leu 
    130                 135                 140                 


Ser Cys Ala Gly Phe Val Asn His Phe Gly Arg Ser Met Ser Val Glu 
145                 150                 155                 160 


Lys Ile Asp Ile Ser Pro Val Leu Leu Gln Lys Gly Ser Thr Lys Ile 
                165                 170                 175     


Ala Leu Tyr Gly Leu Gly Ser Ile Pro Asp Glu Arg Leu Tyr Arg Met 
            180                 185                 190         


Phe Val Asn Lys Lys Val Thr Met Leu Arg Pro Lys Glu Asp 
        195                 200                 205     


<210>  528
<211>  298
<212>  PRT
<213>  Homo sapiens

<400>  528

Met Ser Gln Glu Gly Asp Tyr Gly Arg Trp Thr Ile Ser Ser Ser Asp 
1               5                   10                  15      


Glu Ser Glu Glu Glu Lys Pro Lys Pro Asp Lys Pro Ser Thr Ser Ser 
            20                  25                  30          


Leu Leu Cys Ala Arg Gln Gly Ala Ala Asn Glu Pro Arg Tyr Thr Cys 
        35                  40                  45              


Ser Glu Ala Gln Lys Ala Ala His Lys Arg Lys Ile Ser Pro Val Lys 
    50                  55                  60                  


Phe Ser Asn Thr Asp Ser Val Leu Pro Pro Lys Arg Gln Lys Ser Gly 
65                  70                  75                  80  


Ser Gln Glu Asp Leu Gly Trp Cys Leu Ser Ser Ser Asp Asp Glu Leu 
                85                  90                  95      


Gln Pro Glu Met Pro Gln Lys Gln Ala Glu Lys Val Val Ile Lys Lys 
            100                 105                 110         


Glu Lys Asp Ile Ser Ala Pro Asn Asp Gly Thr Ala Gln Arg Thr Glu 
        115                 120                 125             


Asn His Gly Ala Pro Ala Cys His Arg Leu Lys Glu Glu Glu Asp Glu 
    130                 135                 140                 


Tyr Glu Thr Ser Gly Glu Gly Gln Asp Ile Trp Asp Met Leu Asp Lys 
145                 150                 155                 160 


Gly Asn Pro Phe Gln Phe Tyr Leu Thr Arg Val Ser Gly Val Lys Pro 
                165                 170                 175     


Lys Tyr Asn Ser Gly Ala Leu His Ile Lys Asp Ile Leu Ser Pro Leu 
            180                 185                 190         


Phe Gly Thr Leu Val Ser Ser Ala Gln Phe Asn Tyr Cys Phe Asp Val 
        195                 200                 205             


Asp Trp Leu Val Lys Gln Tyr Pro Pro Glu Phe Arg Lys Lys Pro Ile 
    210                 215                 220                 


Leu Leu Val His Gly Asp Lys Arg Glu Ala Lys Ala His Leu His Ala 
225                 230                 235                 240 


Gln Ala Lys Pro Tyr Glu Asn Ile Ser Leu Cys Gln Ala Lys Leu Asp 
                245                 250                 255     


Ile Ala Phe Gly Thr His His Thr Lys Met Met Leu Leu Leu Tyr Glu 
            260                 265                 270         


Glu Gly Leu Arg Val Val Ile His Thr Ser Asn Leu Ile His Ala Asp 
        275                 280                 285             


Trp His Gln Lys Thr Gln Gly Thr His Leu 
    290                 295             


<210>  529
<211>  514
<212>  PRT
<213>  Homo sapiens

<400>  529

Met Glu Asp Ser Glu Phe Leu Ala Tyr Val Glu Leu Leu Asp Glu Val 
1               5                   10                  15      


Glu Gln Gly Ser Val Arg Ala Lys Ala Ser Ser Val Ser Leu His Ala 
            20                  25                  30          


Glu Arg Thr Trp Met Glu Lys Met Lys Val Glu Asp Leu Asn Val Cys 
        35                  40                  45              


Glu Pro Ala Ser Pro Ala Pro Glu Ala Pro Ala Thr Ser Leu Leu Asn 
    50                  55                  60                  


Asp Leu Lys Tyr Ser Pro Ser Glu Glu Glu Glu Val Thr Tyr Thr Val 
65                  70                  75                  80  


Ile Asn Gln Phe Gln Gln Lys Phe Gly Ala Ala Ile Leu His Ile Lys 
                85                  90                  95      


Lys Gln Asn Val Leu Ser Val Ala Ala Glu Gly Ala Asn Val Cys Arg 
            100                 105                 110         


His Gly Lys Leu Cys Trp Leu Gln Val Ala Thr Asn Cys Arg Val Tyr 
        115                 120                 125             


Leu Phe Asp Ile Phe Leu Leu Gly Ser Arg Ala Phe His Asn Gly Leu 
    130                 135                 140                 


Gln Met Ile Leu Glu Asp Lys Arg Ile Leu Lys Val Ile His Asp Cys 
145                 150                 155                 160 


Arg Trp Leu Ser Asp Cys Leu Ser His Gln Tyr Gly Ile Leu Leu Asn 
                165                 170                 175     


Asn Val Phe Asp Thr Gln Val Ala Asp Val Leu Gln Phe Ser Met Glu 
            180                 185                 190         


Thr Gly Gly Tyr Leu Pro Asn Cys Ile Thr Thr Leu Gln Glu Ser Leu 
        195                 200                 205             


Ile Lys His Leu Gln Val Ala Pro Lys Tyr Leu Ser Phe Leu Glu Lys 
    210                 215                 220                 


Arg Gln Lys Leu Ile Gln Glu Asn Pro Glu Val Trp Phe Ile Arg Pro 
225                 230                 235                 240 


Val Ser Pro Ser Leu Leu Lys Ile Leu Ala Leu Glu Ala Thr Tyr Leu 
                245                 250                 255     


Leu Pro Leu Arg Leu Ala Leu Leu Asp Glu Met Met Ser Asp Leu Thr 
            260                 265                 270         


Thr Leu Val Asp Gly Tyr Leu Asn Thr Tyr Arg Glu Gly Ser Ala Asp 
        275                 280                 285             


Arg Leu Gly Gly Thr Glu Pro Thr Cys Met Glu Leu Pro Glu Glu Leu 
    290                 295                 300                 


Leu Gln Leu Lys Asp Phe Gln Lys Gln Arg Arg Glu Lys Ala Ala Arg 
305                 310                 315                 320 


Glu Tyr Arg Val Asn Ala Gln Gly Leu Leu Ile Arg Thr Val Leu Gln 
                325                 330                 335     


Pro Lys Lys Leu Val Thr Glu Thr Ala Gly Lys Glu Glu Lys Val Lys 
            340                 345                 350         


Gly Phe Leu Phe Gly Lys Asn Phe Arg Ile Asp Lys Ala Pro Ser Phe 
        355                 360                 365             


Thr Ser Gln Asp Phe His Gly Asp Val Asn Leu Leu Lys Glu Glu Ser 
    370                 375                 380                 


Leu Asn Lys Gln Ala Thr Asn Pro Gln His Leu Pro Pro Thr Glu Glu 
385                 390                 395                 400 


Gly Glu Thr Ser Glu Asp Ser Ser Asn Lys Leu Ile Cys Thr Lys Ser 
                405                 410                 415     


Lys Gly Ser Glu Asp Gln Arg Ile Thr Gln Lys Glu His Phe Met Thr 
            420                 425                 430         


Pro Lys His Glu Phe Gln Ala Ser Leu Ser Leu Lys Glu Glu Thr Glu 
        435                 440                 445             


Gln Leu Leu Met Val Glu Asn Lys Glu Asp Leu Lys Cys Thr Lys Gln 
    450                 455                 460                 


Ala Val Ser Met Ser Ser Phe Pro Gln Glu Thr Arg Val Ser Pro Ser 
465                 470                 475                 480 


Asp Thr Phe Tyr Pro Ile Arg Lys Thr Val Val Ser Thr Leu Pro Pro 
                485                 490                 495     


Cys Pro Ala Leu Glu Lys Ile Asp Ser Trp Ile Ser Pro Phe Leu Asn 
            500                 505                 510         


Leu Pro 
        


<210>  530
<211>  458
<212>  PRT
<213>  Homo sapiens

<400>  530

Met Ser Tyr Tyr His His His His His His Asp Tyr Asp Ile Pro Thr 
1               5                   10                  15      


Thr Glu Asn Leu Tyr Phe Gln Gly Ile Thr Ser Leu Tyr Lys Lys Ala 
            20                  25                  30          


Gly Thr Met Ser Asp Ser Lys Cys Asp Ser Gln Phe Tyr Ser Val Gln 
        35                  40                  45              


Val Ala Asp Ser Thr Phe Thr Val Leu Lys Arg Tyr Gln Gln Leu Lys 
    50                  55                  60                  


Pro Ile Gly Ser Gly Ala Gln Gly Ile Val Cys Ala Ala Phe Asp Thr 
65                  70                  75                  80  


Val Leu Gly Ile Asn Val Ala Val Lys Lys Leu Ser Arg Pro Phe Gln 
                85                  90                  95      


Asn Gln Thr His Ala Lys Arg Ala Tyr Arg Glu Leu Val Leu Leu Lys 
            100                 105                 110         


Cys Val Asn His Lys Asn Ile Ile Ser Leu Leu Asn Val Phe Thr Pro 
        115                 120                 125             


Gln Lys Thr Leu Glu Glu Phe Gln Asp Val Tyr Leu Val Met Glu Leu 
    130                 135                 140                 


Met Asp Ala Asn Leu Cys Gln Val Ile His Met Glu Leu Asp His Glu 
145                 150                 155                 160 


Arg Met Ser Tyr Leu Leu Tyr Gln Met Leu Cys Gly Ile Lys His Leu 
                165                 170                 175     


His Ser Ala Gly Ile Ile His Arg Asp Leu Lys Pro Ser Asn Ile Val 
            180                 185                 190         


Val Lys Ser Asp Cys Thr Leu Lys Ile Leu Asp Phe Gly Leu Ala Arg 
        195                 200                 205             


Thr Ala Cys Thr Asn Phe Met Met Thr Pro Tyr Val Val Thr Arg Tyr 
    210                 215                 220                 


Tyr Arg Ala Pro Glu Val Ile Leu Gly Met Gly Tyr Lys Glu Asn Val 
225                 230                 235                 240 


Asp Ile Trp Ser Val Gly Cys Ile Met Gly Glu Leu Val Lys Gly Cys 
                245                 250                 255     


Val Ile Phe Gln Gly Thr Asp His Ile Asp Gln Trp Asn Lys Val Ile 
            260                 265                 270         


Glu Gln Leu Gly Thr Pro Ser Ala Glu Phe Met Lys Lys Leu Gln Pro 
        275                 280                 285             


Thr Val Arg Asn Tyr Val Glu Asn Arg Pro Lys Tyr Pro Gly Ile Lys 
    290                 295                 300                 


Phe Glu Glu Leu Phe Pro Asp Trp Ile Phe Pro Ser Glu Ser Glu Arg 
305                 310                 315                 320 


Asp Lys Ile Lys Thr Ser Gln Ala Arg Asp Leu Leu Ser Lys Met Leu 
                325                 330                 335     


Val Ile Asp Pro Asp Lys Arg Ile Ser Val Asp Glu Ala Leu Arg His 
            340                 345                 350         


Pro Tyr Ile Thr Val Trp Tyr Asp Pro Ala Glu Ala Glu Ala Pro Pro 
        355                 360                 365             


Pro Gln Ile Tyr Asp Ala Gln Leu Glu Glu Arg Glu His Ala Ile Glu 
    370                 375                 380                 


Glu Trp Lys Glu Leu Ile Tyr Lys Glu Val Met Asp Trp Glu Glu Arg 
385                 390                 395                 400 


Ser Lys Asn Gly Val Val Lys Asp Gln Pro Ser Asp Ala Ala Val Ser 
                405                 410                 415     


Ser Asn Ala Thr Pro Ser Gln Ser Ser Ser Ile Asn Asp Ile Ser Ser 
            420                 425                 430         


Met Ser Thr Glu Gln Thr Leu Ala Ser Asp Thr Asp Ser Ser Leu Asp 
        435                 440                 445             


Ala Ser Thr Gly Pro Leu Glu Gly Cys Arg 
    450                 455             


<210>  531
<211>  282
<212>  PRT
<213>  Homo sapiens

<400>  531

Met Glu Gly Asp Phe Ser Val Cys Arg Asn Cys Lys Arg His Val Val 
1               5                   10                  15      


Ser Ala Asn Phe Thr Leu His Glu Ala Tyr Cys Leu Arg Phe Leu Val 
            20                  25                  30          


Leu Cys Pro Glu Cys Glu Glu Pro Val Pro Lys Glu Thr Met Glu Glu 
        35                  40                  45              


His Cys Lys Leu Glu His Gln Gln Ala Asn Glu Cys Gln Glu Arg Pro 
    50                  55                  60                  


Val Glu Cys Lys Phe Cys Lys Leu Asp Met Gln Leu Ser Lys Leu Glu 
65                  70                  75                  80  


Leu His Glu Ser Tyr Cys Gly Ser Arg Thr Glu Leu Cys Gln Gly Cys 
                85                  90                  95      


Gly Gln Phe Ile Met His Arg Met Leu Ala Gln His Arg Asp Val Cys 
            100                 105                 110         


Arg Ser Glu Gln Ala Gln Leu Gly Lys Gly Glu Arg Ile Ser Ala Pro 
        115                 120                 125             


Glu Arg Glu Ile Tyr Cys His Tyr Cys Asn Gln Met Ile Pro Glu Asn 
    130                 135                 140                 


Lys Tyr Phe His His Met Gly Lys Cys Cys Pro Asp Ser Glu Phe Lys 
145                 150                 155                 160 


Lys His Phe Pro Val Gly Asn Pro Glu Ile Leu Pro Ser Ser Leu Pro 
                165                 170                 175     


Ser Gln Ala Ala Glu Asn Gln Thr Ser Thr Met Glu Lys Asp Val Arg 
            180                 185                 190         


Pro Lys Thr Arg Ser Ile Asn Arg Phe Pro Leu His Ser Glu Ser Ser 
        195                 200                 205             


Ser Lys Lys Ala Pro Arg Ser Lys Asn Lys Thr Leu Asp Pro Leu Leu 
    210                 215                 220                 


Met Ser Glu Pro Lys Pro Arg Thr Ser Ser Pro Arg Gly Asp Lys Ala 
225                 230                 235                 240 


Ala Tyr Asp Ile Leu Arg Arg Cys Ser Gln Cys Gly Ile Leu Leu Pro 
                245                 250                 255     


Leu Pro Ile Leu Asn Gln His Gln Glu Lys Cys Arg Trp Leu Ala Ser 
            260                 265                 270         


Ser Lys Gly Lys Gln Val Arg Asn Phe Ser 
        275                 280         


<210>  532
<211>  276
<212>  PRT
<213>  Homo sapiens

<400>  532

Met Gly Gln Val Leu Pro Val Phe Ala His Cys Lys Glu Ala Pro Ser 
1               5                   10                  15      


Thr Ala Ser Ser Thr Pro Asp Ser Thr Glu Gly Gly Asn Asp Asp Ser 
            20                  25                  30          


Asp Phe Arg Glu Leu His Thr Ala Arg Glu Phe Ser Glu Glu Asp Glu 
        35                  40                  45              


Glu Glu Thr Thr Ser Gln Asp Trp Gly Thr Pro Arg Glu Leu Thr Phe 
    50                  55                  60                  


Ser Tyr Ile Ala Phe Asp Gly Val Val Gly Ser Gly Gly Arg Arg Asp 
65                  70                  75                  80  


Ser Thr Ala Arg Arg Pro Arg Pro Gln Gly Arg Ser Val Ser Glu Pro 
                85                  90                  95      


Arg Asp Gln His Pro Gln Pro Ser Leu Gly Asp Ser Leu Glu Ser Ile 
            100                 105                 110         


Pro Ser Leu Ser Gln Ser Pro Glu Pro Gly Arg Arg Gly Asp Pro Asp 
        115                 120                 125             


Thr Ala Pro Pro Ser Glu Arg Pro Leu Glu Asp Leu Arg Leu Arg Leu 
    130                 135                 140                 


Asp His Leu Gly Trp Val Ala Arg Gly Thr Gly Ser Gly Glu Asp Ser 
145                 150                 155                 160 


Ser Thr Ser Ser Ser Thr Pro Leu Glu Asp Glu Glu Pro Gln Glu Pro 
                165                 170                 175     


Asn Arg Leu Glu Thr Gly Glu Ala Gly Glu Glu Leu Asp Leu Arg Leu 
            180                 185                 190         


Arg Leu Ala Gln Pro Ser Ser Pro Glu Val Leu Thr Pro Gln Leu Ser 
        195                 200                 205             


Pro Gly Ser Gly Thr Pro Gln Ala Gly Thr Pro Ser Pro Ser Arg Ser 
    210                 215                 220                 


Arg Asp Ser Asn Ser Gly Pro Glu Glu Pro Leu Leu Glu Glu Glu Glu 
225                 230                 235                 240 


Lys Gln Trp Gly Pro Leu Glu Arg Glu Pro Val Arg Gly Gln Cys Leu 
                245                 250                 255     


Asp Ser Thr Asp Gln Leu Glu Phe Thr Val Glu Pro Arg Leu Leu Gly 
            260                 265                 270         


Lys Gln Arg Val 
        275     


<210>  533
<211>  398
<212>  PRT
<213>  Homo sapiens

<400>  533

Met Ala Leu Leu Arg Arg Pro Thr Val Ser Ser Asp Leu Glu Asn Ile 
1               5                   10                  15      


Asp Thr Gly Val Asn Ser Lys Val Lys Ser His Val Thr Ile Arg Arg 
            20                  25                  30          


Thr Val Leu Glu Glu Ile Gly Asn Arg Val Thr Thr Arg Ala Ala Gln 
        35                  40                  45              


Val Ala Lys Lys Ala Gln Asn Thr Lys Val Pro Val Gln Pro Thr Lys 
    50                  55                  60                  


Thr Thr Asn Val Asn Lys Gln Leu Lys Pro Thr Ala Ser Val Lys Pro 
65                  70                  75                  80  


Val Gln Met Glu Lys Leu Ala Pro Lys Gly Pro Ser Pro Thr Pro Glu 
                85                  90                  95      


Asp Val Ser Met Lys Glu Glu Asn Leu Cys Gln Ala Phe Ser Asp Ala 
            100                 105                 110         


Leu Leu Cys Lys Ile Glu Asp Ile Asp Asn Glu Asp Trp Glu Asn Pro 
        115                 120                 125             


Gln Leu Cys Ser Asp Tyr Val Lys Asp Ile Tyr Gln Tyr Leu Arg Gln 
    130                 135                 140                 


Leu Glu Val Leu Gln Ser Ile Asn Pro His Phe Leu Asp Gly Arg Asp 
145                 150                 155                 160 


Ile Asn Gly Arg Met Arg Ala Ile Leu Val Asp Trp Leu Val Gln Val 
                165                 170                 175     


His Ser Lys Phe Arg Leu Leu Gln Glu Thr Leu Tyr Met Cys Val Gly 
            180                 185                 190         


Ile Met Asp Arg Phe Leu Gln Val Gln Pro Val Ser Arg Lys Lys Leu 
        195                 200                 205             


Gln Leu Val Gly Ile Thr Ala Leu Leu Leu Ala Ser Lys Tyr Glu Glu 
    210                 215                 220                 


Met Phe Ser Pro Asn Ile Glu Asp Phe Val Tyr Ile Thr Asp Asn Ala 
225                 230                 235                 240 


Tyr Thr Ser Ser Gln Ile Arg Glu Met Glu Thr Leu Ile Leu Lys Glu 
                245                 250                 255     


Leu Lys Phe Glu Leu Gly Arg Pro Leu Pro Leu His Phe Leu Arg Arg 
            260                 265                 270         


Ala Ser Lys Ala Gly Glu Val Asp Val Glu Gln His Thr Leu Ala Lys 
        275                 280                 285             


Tyr Leu Met Glu Leu Thr Leu Ile Asp Tyr Asp Met Val His Tyr His 
    290                 295                 300                 


Pro Ser Lys Val Ala Ala Ala Ala Ser Cys Leu Ser Gln Lys Val Leu 
305                 310                 315                 320 


Gly Gln Gly Lys Trp Asn Leu Lys Gln Gln Tyr Tyr Thr Gly Tyr Thr 
                325                 330                 335     


Glu Asn Glu Val Leu Glu Val Met Gln His Met Ala Lys Asn Val Val 
            340                 345                 350         


Lys Val Asn Glu Asn Leu Thr Lys Phe Ile Ala Ile Lys Asn Lys Tyr 
        355                 360                 365             


Ala Ser Ser Lys Leu Leu Lys Ile Ser Met Ile Pro Gln Leu Asn Ser 
    370                 375                 380                 


Lys Ala Val Lys Asp Leu Ala Ser Pro Leu Ile Gly Arg Ser 
385                 390                 395             


<210>  534
<211>  388
<212>  PRT
<213>  Homo sapiens

<400>  534

Met Ala Ala Ala Ala Ala Leu Ala Arg Leu Glu Gln Lys Gln Ser Arg 
1               5                   10                  15      


Ala Trp Gly Pro Thr Ser Gln Asp Thr Ile Arg Asn Gln Val Arg Lys 
            20                  25                  30          


Glu Leu Gln Ala Glu Ala Thr Val Ser Gly Ser Pro Glu Ala Pro Gly 
        35                  40                  45              


Thr Asn Val Val Ser Glu Pro Arg Glu Glu Gly Ser Ala His Leu Ala 
    50                  55                  60                  


Val Pro Gly Val Tyr Phe Thr Cys Pro Leu Thr Gly Ala Thr Leu Arg 
65                  70                  75                  80  


Lys Asp Gln Arg Asp Ala Cys Ile Lys Glu Ala Ile Leu Leu His Phe 
                85                  90                  95      


Ser Thr Asp Pro Val Ala Ala Ser Ile Met Lys Ile Tyr Thr Phe Asn 
            100                 105                 110         


Lys Asp Gln Asp Arg Val Lys Leu Gly Val Asp Thr Ile Ala Lys Tyr 
        115                 120                 125             


Leu Asp Asn Ile His Leu His Pro Glu Glu Glu Lys Tyr Arg Lys Ile 
    130                 135                 140                 


Lys Leu Gln Asn Lys Val Phe Gln Glu Arg Ile Asn Cys Leu Glu Gly 
145                 150                 155                 160 


Thr His Glu Phe Phe Glu Ala Ile Gly Phe Gln Lys Val Leu Leu Pro 
                165                 170                 175     


Ala Gln Asp Gln Glu Asp Pro Glu Glu Phe Tyr Val Leu Ser Glu Thr 
            180                 185                 190         


Thr Leu Ala Gln Pro Gln Ser Leu Glu Arg His Lys Glu Gln Leu Leu 
        195                 200                 205             


Ala Ala Glu Pro Val Arg Ala Lys Leu Asp Arg Gln Arg Arg Val Phe 
    210                 215                 220                 


Gln Pro Ser Pro Leu Ala Ser Gln Phe Glu Leu Pro Gly Asp Phe Phe 
225                 230                 235                 240 


Asn Leu Thr Ala Glu Glu Ile Lys Arg Glu Gln Arg Leu Arg Ser Glu 
                245                 250                 255     


Ala Val Glu Arg Leu Ser Val Leu Arg Thr Lys Ala Met Arg Glu Lys 
            260                 265                 270         


Glu Glu Gln Arg Gly Leu Arg Lys Tyr Asn Tyr Thr Leu Leu Arg Val 
        275                 280                 285             


Arg Leu Pro Asp Gly Cys Leu Leu Gln Gly Thr Phe Tyr Ala Arg Glu 
    290                 295                 300                 


Arg Leu Gly Ala Val Tyr Gly Phe Val Arg Glu Ala Leu Gln Ser Asp 
305                 310                 315                 320 


Trp Leu Pro Phe Glu Leu Leu Ala Ser Gly Gly Gln Lys Leu Ser Glu 
                325                 330                 335     


Asp Glu Asn Leu Ala Leu Asn Glu Cys Gly Leu Val Pro Ser Ala Leu 
            340                 345                 350         


Leu Thr Phe Ser Trp Asp Met Ala Val Leu Glu Asp Ile Lys Ala Ala 
        355                 360                 365             


Gly Ala Glu Pro Asp Ser Ile Leu Lys Pro Glu Leu Leu Ser Ala Ile 
    370                 375                 380                 


Glu Lys Leu Leu 
385             


<210>  535
<211>  694
<212>  PRT
<213>  Homo sapiens

<400>  535

Met Ser Tyr Tyr His His His His His His Asp Tyr Asp Ile Pro Thr 
1               5                   10                  15      


Thr Glu Asn Leu Tyr Phe Gln Gly Ile Thr Ser Leu Tyr Lys Lys Ala 
            20                  25                  30          


Gly Thr Met Glu Gly Ala Ala Ala Pro Val Ala Gly Asp Arg Pro Asp 
        35                  40                  45              


Leu Gly Leu Gly Ala Pro Gly Ser Pro Arg Glu Ala Val Ala Gly Ala 
    50                  55                  60                  


Thr Ala Ala Leu Glu Pro Arg Lys Pro His Gly Val Lys Arg His His 
65                  70                  75                  80  


His Lys His Asn Leu Lys His Arg Tyr Glu Leu Gln Glu Thr Leu Gly 
                85                  90                  95      


Lys Gly Thr Tyr Gly Lys Val Lys Arg Ala Thr Glu Arg Phe Ser Gly 
            100                 105                 110         


Arg Val Val Ala Ile Lys Ser Ile Arg Lys Asp Lys Ile Lys Asp Glu 
        115                 120                 125             


Gln Asp Met Val His Ile Arg Arg Glu Ile Glu Ile Met Ser Ser Leu 
    130                 135                 140                 


Asn His Pro His Ile Ile Ser Ile Tyr Glu Val Phe Glu Asn Lys Asp 
145                 150                 155                 160 


Lys Ile Val Ile Ile Met Glu Tyr Ala Ser Lys Gly Glu Leu Tyr Asp 
                165                 170                 175     


Tyr Ile Ser Glu Arg Arg Arg Leu Ser Glu Arg Glu Thr Arg His Phe 
            180                 185                 190         


Phe Arg Gln Ile Val Ser Ala Val His Tyr Cys His Lys Asn Gly Val 
        195                 200                 205             


Val His Arg Asp Leu Lys Leu Glu Asn Ile Leu Leu Asp Asp Asn Cys 
    210                 215                 220                 


Asn Ile Lys Ile Ala Asp Phe Gly Leu Ser Asn Leu Tyr Gln Lys Asp 
225                 230                 235                 240 


Lys Phe Leu Gln Thr Phe Cys Gly Ser Pro Leu Tyr Ala Ser Pro Glu 
                245                 250                 255     


Ile Val Asn Gly Arg Pro Tyr Arg Gly Pro Glu Val Asp Ser Trp Ala 
            260                 265                 270         


Leu Gly Val Leu Leu Tyr Thr Leu Val Tyr Gly Thr Met Pro Phe Asp 
        275                 280                 285             


Gly Phe Asp His Lys Asn Leu Ile Arg Gln Ile Ser Ser Gly Glu Tyr 
    290                 295                 300                 


Arg Glu Pro Thr Gln Pro Ser Asp Ala Arg Gly Leu Ile Arg Trp Met 
305                 310                 315                 320 


Leu Met Val Asn Pro Asp Arg Arg Ala Thr Ile Glu Asp Ile Ala Asn 
                325                 330                 335     


His Trp Trp Val Asn Trp Gly Tyr Lys Ser Ser Val Cys Asp Cys Asp 
            340                 345                 350         


Ala Leu His Asp Ser Glu Ser Pro Leu Leu Ala Arg Ile Ile Asp Trp 
        355                 360                 365             


His His Arg Ser Thr Gly Leu Gln Ala Asp Thr Glu Ala Lys Met Lys 
    370                 375                 380                 


Gly Leu Ala Lys Pro Thr Thr Ser Glu Val Met Leu Glu Arg Gln Arg 
385                 390                 395                 400 


Ser Leu Lys Lys Ser Lys Lys Glu Asn Asp Phe Ala Gln Ser Gly Gln 
                405                 410                 415     


Asp Ala Val Pro Glu Ser Pro Ser Lys Leu Ser Ser Lys Arg Pro Lys 
            420                 425                 430         


Gly Ile Leu Lys Lys Arg Ser Asn Ser Glu His Arg Ser His Ser Thr 
        435                 440                 445             


Gly Phe Ile Glu Gly Val Val Gly Pro Ala Leu Pro Ser Thr Phe Lys 
    450                 455                 460                 


Met Glu Gln Asp Leu Cys Arg Thr Gly Val Leu Leu Pro Ser Ser Pro 
465                 470                 475                 480 


Glu Ala Glu Val Pro Gly Lys Leu Ser Pro Lys Gln Ser Ala Thr Met 
                485                 490                 495     


Pro Lys Lys Gly Ile Leu Lys Lys Thr Gln Gln Arg Glu Ser Gly Tyr 
            500                 505                 510         


Tyr Ser Ser Pro Glu Arg Ser Glu Ser Ser Glu Leu Leu Asp Ser Asn 
        515                 520                 525             


Asp Val Met Gly Ser Ser Ile Pro Ser Pro Ser Pro Pro Asp Pro Ala 
    530                 535                 540                 


Arg Val Thr Ser His Ser Leu Ser Cys Arg Arg Lys Gly Ile Leu Lys 
545                 550                 555                 560 


His Ser Ser Lys Tyr Ser Ala Gly Thr Met Asp Pro Ala Leu Val Ser 
                565                 570                 575     


Pro Glu Met Pro Thr Leu Glu Ser Leu Ser Glu Pro Gly Val Pro Ala 
            580                 585                 590         


Glu Gly Leu Ser Arg Ser Tyr Ser Arg Pro Ser Ser Val Ile Ser Asp 
        595                 600                 605             


Asp Ser Val Leu Ser Ser Asp Ser Phe Asp Leu Leu Asp Leu Gln Glu 
    610                 615                 620                 


Asn Arg Pro Ala Arg Gln Arg Ile Arg Ser Cys Val Ser Ala Glu Asn 
625                 630                 635                 640 


Phe Leu Gln Ile Gln Asp Phe Glu Gly Leu Gln Asn Arg Pro Arg Pro 
                645                 650                 655     


Gln Tyr Leu Lys Arg Tyr Arg Asn Arg Leu Ala Asp Ser Ser Phe Ser 
            660                 665                 670         


Leu Leu Thr Asp Met Asp Asp Val Thr Gln Val Tyr Lys Gln Ala Leu 
        675                 680                 685             


Glu Ile Cys Ser Lys Leu 
    690                 


<210>  536
<211>  423
<212>  PRT
<213>  Homo sapiens

<400>  536

Met Leu Pro Pro Gln Lys Lys Pro Trp Glu Ser Met Ala Lys Gly Leu 
1               5                   10                  15      


Val Leu Gly Ala Leu Phe Thr Ser Phe Leu Leu Leu Met Tyr Ser Tyr 
            20                  25                  30          


Ala Val Pro Pro Leu His Ala Gly Leu Ala Ser Thr Thr Pro Glu Ala 
        35                  40                  45              


Ala Ala Ser Cys Ser Pro Pro Ala Leu Glu Pro Glu Ala Val Ile Arg 
    50                  55                  60                  


Ala Asn Gly Ser Ala Gly Glu Cys Gln Pro Arg Arg Asn Ile Val Phe 
65                  70                  75                  80  


Leu Lys Thr His Lys Thr Ala Ser Ser Thr Leu Leu Asn Ile Leu Phe 
                85                  90                  95      


Arg Phe Gly Gln Lys His Arg Leu Lys Phe Ala Phe Pro Asn Gly Arg 
            100                 105                 110         


Asn Asp Phe Asp Tyr Pro Thr Phe Phe Ala Arg Ser Leu Val Gln Asp 
        115                 120                 125             


Tyr Arg Pro Gly Ala Cys Phe Asn Ile Ile Cys Asn His Met Arg Phe 
    130                 135                 140                 


His Tyr Asp Glu Val Arg Gly Leu Val Pro Thr Asn Ala Ile Phe Ile 
145                 150                 155                 160 


Thr Val Leu Arg Asp Pro Ala Arg Leu Phe Glu Ser Ser Phe His Tyr 
                165                 170                 175     


Phe Gly Pro Val Val Pro Leu Thr Trp Lys Leu Ser Ala Gly Asp Lys 
            180                 185                 190         


Leu Thr Glu Phe Leu Gln Asp Pro Asp Arg Tyr Tyr Asp Pro Asn Gly 
        195                 200                 205             


Phe Asn Ala His Tyr Leu Arg Asn Leu Leu Phe Phe Asp Leu Gly Tyr 
    210                 215                 220                 


Asp Asn Ser Leu Asp Pro Ser Ser Pro Gln Val Gln Glu His Ile Leu 
225                 230                 235                 240 


Glu Val Glu Arg Arg Phe His Leu Val Leu Leu Gln Glu Tyr Phe Asp 
                245                 250                 255     


Glu Ser Leu Val Leu Leu Lys Asp Leu Leu Cys Trp Glu Leu Glu Asp 
            260                 265                 270         


Val Leu Tyr Phe Lys Leu Asn Ala Arg Arg Asp Ser Pro Val Pro Arg 
        275                 280                 285             


Leu Ser Gly Glu Leu Tyr Gly Arg Ala Thr Ala Trp Asn Met Leu Asp 
    290                 295                 300                 


Ser His Leu Tyr Arg His Phe Asn Ala Ser Phe Trp Arg Lys Val Glu 
305                 310                 315                 320 


Ala Phe Gly Arg Glu Arg Met Ala Arg Glu Val Ala Ala Leu Arg His 
                325                 330                 335     


Ala Asn Glu Arg Met Arg Thr Ile Cys Ile Asp Gly Gly His Ala Val 
            340                 345                 350         


Asp Ala Ala Ala Ile Gln Asp Glu Ala Met Gln Pro Trp Gln Pro Leu 
        355                 360                 365             


Gly Thr Lys Ser Ile Leu Gly Tyr Asn Leu Lys Lys Ser Ile Gly Gln 
    370                 375                 380                 


Arg His Ala Gln Leu Cys Arg Arg Met Leu Thr Pro Glu Ile Gln Tyr 
385                 390                 395                 400 


Leu Met Asp Leu Gly Ala Asn Leu Trp Val Thr Lys Leu Trp Lys Phe 
                405                 410                 415     


Ile Arg Asp Phe Leu Arg Trp 
            420             


<210>  537
<211>  277
<212>  PRT
<213>  Homo sapiens

<400>  537

Met Val Arg Leu Pro Leu Gln Cys Val Leu Trp Gly Cys Leu Leu Thr 
1               5                   10                  15      


Ala Val His Pro Glu Pro Pro Thr Ala Cys Arg Glu Lys Gln Tyr Leu 
            20                  25                  30          


Ile Asn Ser Gln Cys Cys Ser Leu Cys Gln Pro Gly Gln Lys Leu Val 
        35                  40                  45              


Ser Asp Cys Thr Glu Phe Thr Glu Thr Glu Cys Leu Pro Cys Gly Glu 
    50                  55                  60                  


Ser Glu Phe Leu Asp Thr Trp Asn Arg Glu Thr His Cys His Gln His 
65                  70                  75                  80  


Lys Tyr Cys Asp Pro Asn Leu Gly Leu Arg Val Gln Gln Lys Gly Thr 
                85                  90                  95      


Ser Glu Thr Asp Thr Ile Cys Thr Cys Glu Glu Gly Trp His Cys Thr 
            100                 105                 110         


Ser Glu Ala Cys Glu Ser Cys Val Leu His Arg Ser Cys Ser Pro Gly 
        115                 120                 125             


Phe Gly Val Lys Gln Ile Ala Thr Gly Val Ser Asp Thr Ile Cys Glu 
    130                 135                 140                 


Pro Cys Pro Val Gly Phe Phe Ser Asn Val Ser Ser Ala Phe Glu Lys 
145                 150                 155                 160 


Cys His Pro Trp Thr Ser Cys Glu Thr Lys Asp Leu Val Val Gln Gln 
                165                 170                 175     


Ala Gly Thr Asn Lys Thr Asp Val Val Cys Gly Pro Gln Asp Arg Leu 
            180                 185                 190         


Arg Ala Leu Val Val Ile Pro Ile Ile Phe Gly Ile Leu Phe Ala Ile 
        195                 200                 205             


Leu Leu Val Leu Val Phe Ile Lys Lys Val Ala Lys Lys Pro Thr Asn 
    210                 215                 220                 


Lys Ala Pro His Pro Lys Gln Glu Pro Gln Glu Ile Asn Phe Pro Asp 
225                 230                 235                 240 


Asp Leu Pro Gly Ser Asn Thr Ala Ala Pro Val Gln Glu Thr Leu His 
                245                 250                 255     


Gly Cys Gln Pro Val Thr Gln Glu Asp Gly Lys Glu Ser Arg Ile Ser 
            260                 265                 270         


Val Gln Glu Arg Gln 
        275         


<210>  538
<211>  148
<212>  PRT
<213>  Homo sapiens

<400>  538

Met Thr Lys Ala Leu Leu Ile Tyr Leu Val Ser Ser Phe Leu Ala Leu 
1               5                   10                  15      


Asn Gln Ala Ser Leu Ile Ser Arg Cys Asp Leu Ala Gln Val Leu Gln 
            20                  25                  30          


Leu Glu Asp Leu Asp Gly Phe Glu Gly Tyr Ser Leu Ser Asp Trp Leu 
        35                  40                  45              


Cys Leu Ala Phe Val Glu Ser Lys Phe Asn Ile Ser Lys Ile Asn Glu 
    50                  55                  60                  


Asn Ala Asp Gly Ser Phe Asp Tyr Gly Leu Phe Gln Ile Asn Ser His 
65                  70                  75                  80  


Tyr Trp Cys Asn Asp Tyr Lys Ser Tyr Ser Glu Asn Leu Cys His Val 
                85                  90                  95      


Asp Cys Gln Asp Leu Leu Asn Pro Asn Leu Leu Ala Gly Ile His Cys 
            100                 105                 110         


Ala Lys Arg Ile Val Ser Gly Ala Arg Gly Met Asn Asn Trp Val Glu 
        115                 120                 125             


Trp Arg Leu His Cys Ser Gly Arg Pro Leu Phe Tyr Trp Leu Thr Gly 
    130                 135                 140                 


Cys Arg Leu Arg 
145             


<210>  539
<211>  95
<212>  PRT
<213>  Homo sapiens

<400>  539

Met Ser His Ser Tyr Lys Lys Ala Ile Ser Asp Glu Ala Leu Arg Pro 
1               5                   10                  15      


Phe Gln Met Asp Tyr Phe Gly Gly Leu Pro Pro Gly Gln Tyr Ala Thr 
            20                  25                  30          


Arg Met Thr Gly Gln Val His Gly Ser Gly Cys His Leu Arg Ser Ala 
        35                  40                  45              


Pro Cys Asp Leu Gly Ala Ser Gln Arg Lys Leu Ser Ser Asn Phe Ser 
    50                  55                  60                  


Glu Ile Asp Ala Gly Leu Phe Ser Gln Gly Lys Ser Ala Ala Tyr Thr 
65                  70                  75                  80  


Asp Ile Gly Ala Thr Lys Pro Val Glu Gln Arg Glu Thr Ala Ser 
                85                  90                  95  


<210>  540
<211>  729
<212>  PRT
<213>  Homo sapiens

<400>  540

Met Asn Lys Gly Trp Leu Glu Leu Glu Ser Asp Pro Gly Leu Phe Thr 
1               5                   10                  15      


Leu Leu Val Glu Asp Phe Gly Val Lys Gly Val Gln Val Glu Glu Ile 
            20                  25                  30          


Tyr Asp Leu Gln Ser Lys Cys Gln Gly Pro Val Tyr Gly Phe Ile Phe 
        35                  40                  45              


Leu Phe Lys Trp Ile Glu Glu Arg Arg Ser Arg Arg Lys Val Ser Thr 
    50                  55                  60                  


Leu Val Asp Asp Thr Ser Val Ile Asp Asp Asp Ile Val Asn Asn Met 
65                  70                  75                  80  


Phe Phe Ala His Gln Leu Ile Pro Asn Ser Cys Ala Thr His Ala Leu 
                85                  90                  95      


Leu Ser Val Leu Leu Asn Cys Ser Ser Val Asp Leu Gly Pro Thr Leu 
            100                 105                 110         


Ser Arg Met Lys Asp Phe Thr Lys Gly Phe Ser Pro Glu Ser Lys Gly 
        115                 120                 125             


Tyr Ala Ile Gly Asn Ala Pro Glu Leu Ala Lys Ala His Asn Ser His 
    130                 135                 140                 


Ala Arg Pro Glu Pro Arg His Leu Pro Glu Lys Gln Asn Gly Leu Ser 
145                 150                 155                 160 


Ala Val Arg Thr Met Glu Ala Phe His Phe Val Ser Tyr Val Pro Ile 
                165                 170                 175     


Thr Gly Arg Leu Phe Glu Leu Asp Gly Leu Lys Val Tyr Pro Ile Asp 
            180                 185                 190         


His Gly Pro Trp Gly Glu Asp Glu Glu Trp Thr Asp Lys Ala Arg Arg 
        195                 200                 205             


Val Ile Met Glu Arg Ile Gly Leu Ala Thr Ala Gly Glu Pro Tyr His 
    210                 215                 220                 


Asp Ile Arg Phe Asn Leu Met Ala Val Val Pro Asp Arg Arg Ile Lys 
225                 230                 235                 240 


Tyr Glu Ala Arg Leu His Val Leu Lys Val Asn Arg Gln Thr Val Leu 
                245                 250                 255     


Glu Ala Leu Gln Gln Leu Ile Arg Val Thr Gln Pro Glu Leu Ile Gln 
            260                 265                 270         


Thr His Lys Ser Gln Glu Ser Gln Leu Pro Glu Glu Ser Lys Ser Ala 
        275                 280                 285             


Ser Asn Lys Ser Pro Leu Val Leu Glu Ala Asn Arg Ala Pro Ala Ala 
    290                 295                 300                 


Ser Glu Gly Asn His Thr Asp Gly Ala Glu Glu Ala Ala Gly Ser Cys 
305                 310                 315                 320 


Ala Gln Ala Pro Ser His Ser Pro Pro Asn Lys Pro Lys Leu Val Val 
                325                 330                 335     


Lys Pro Pro Gly Ser Ser Leu Asn Gly Val His Pro Asn Pro Thr Pro 
            340                 345                 350         


Ile Val Gln Arg Leu Pro Ala Phe Leu Asp Asn His Asn Tyr Ala Lys 
        355                 360                 365             


Ser Pro Met Gln Glu Glu Glu Asp Leu Ala Ala Gly Val Gly Arg Ser 
    370                 375                 380                 


Arg Val Pro Val Arg Pro Pro Gln Gln Tyr Ser Asp Asp Glu Asp Asp 
385                 390                 395                 400 


Tyr Glu Asp Asp Glu Glu Asp Asp Val Gln Asn Thr Asn Ser Ala Leu 
                405                 410                 415     


Arg Tyr Lys Gly Lys Gly Thr Gly Lys Pro Gly Ala Leu Ser Gly Ser 
            420                 425                 430         


Ala Asp Gly Gln Leu Ser Val Leu Gln Pro Asn Thr Ile Asn Val Leu 
        435                 440                 445             


Ala Glu Lys Leu Lys Glu Ser Gln Lys Asp Leu Ser Ile Pro Leu Ser 
    450                 455                 460                 


Ile Lys Thr Ser Ser Gly Ala Gly Ser Pro Ala Val Ala Val Pro Thr 
465                 470                 475                 480 


His Ser Gln Pro Ser Pro Thr Pro Ser Asn Glu Ser Thr Asp Thr Ala 
                485                 490                 495     


Ser Glu Ile Gly Ser Ala Phe Asn Ser Pro Leu Arg Ser Pro Ile Arg 
            500                 505                 510         


Ser Ala Asn Pro Thr Arg Pro Ser Ser Pro Val Thr Ser His Ile Ser 
        515                 520                 525             


Lys Val Leu Phe Gly Glu Asp Asp Ser Leu Leu Arg Val Asp Cys Ile 
    530                 535                 540                 


Arg Tyr Asn Arg Ala Val Arg Asp Leu Gly Pro Val Ile Ser Thr Gly 
545                 550                 555                 560 


Leu Leu His Leu Ala Glu Asp Gly Val Leu Ser Pro Leu Ala Leu Thr 
                565                 570                 575     


Glu Gly Gly Lys Gly Ser Ser Pro Ser Ile Arg Pro Ile Gln Gly Ser 
            580                 585                 590         


Gln Gly Ser Ser Ser Pro Val Glu Lys Glu Val Val Glu Ala Thr Asp 
        595                 600                 605             


Ser Arg Glu Lys Thr Gly Met Val Arg Pro Gly Glu Pro Leu Ser Gly 
    610                 615                 620                 


Glu Lys Tyr Ser Pro Lys Glu Leu Leu Ala Leu Leu Lys Cys Val Glu 
625                 630                 635                 640 


Ala Glu Ile Ala Asn Tyr Glu Ala Cys Leu Lys Glu Glu Val Glu Lys 
                645                 650                 655     


Arg Lys Lys Phe Lys Ile Asp Asp Gln Arg Arg Thr His Asn Tyr Asp 
            660                 665                 670         


Glu Phe Ile Cys Thr Phe Ile Ser Met Leu Ala Gln Glu Gly Met Leu 
        675                 680                 685             


Ala Asn Leu Val Glu Gln Asn Ile Ser Val Arg Arg Arg Gln Gly Val 
    690                 695                 700                 


Ser Ile Gly Arg Leu His Lys Gln Arg Lys Pro Asp Arg Arg Lys Arg 
705                 710                 715                 720 


Ser Arg Pro Tyr Lys Ala Lys Arg Gln 
                725                 


<210>  541
<211>  625
<212>  PRT
<213>  Homo sapiens

<400>  541

Met Ser Gln Glu Ser Asp Asn Asn Lys Arg Leu Val Ala Leu Val Pro 
1               5                   10                  15      


Met Pro Ser Asp Pro Pro Phe Asn Thr Arg Arg Ala Tyr Thr Ser Glu 
            20                  25                  30          


Asp Glu Ala Trp Lys Ser Tyr Leu Glu Asn Pro Leu Thr Ala Ala Thr 
        35                  40                  45              


Lys Ala Met Met Ser Ile Asn Gly Asp Glu Asp Ser Ala Ala Ala Leu 
    50                  55                  60                  


Gly Leu Leu Tyr Asp Tyr Tyr Lys Val Pro Arg Asp Lys Arg Leu Leu 
65                  70                  75                  80  


Ser Val Ser Lys Ala Ser Asp Ser Gln Glu Asp Gln Glu Lys Arg Asn 
                85                  90                  95      


Cys Leu Gly Thr Ser Glu Ala Gln Ser Asn Leu Ser Gly Gly Glu Asn 
            100                 105                 110         


Arg Val Gln Val Leu Lys Thr Val Pro Val Asn Leu Ser Leu Asn Gln 
        115                 120                 125             


Asp His Leu Glu Asn Ser Lys Arg Glu Gln Tyr Ser Ile Ser Phe Pro 
    130                 135                 140                 


Glu Ser Ser Ala Ile Ile Pro Val Ser Gly Ile Thr Val Val Lys Ala 
145                 150                 155                 160 


Glu Asp Phe Thr Pro Val Phe Met Ala Pro Pro Val His Tyr Pro Arg 
                165                 170                 175     


Gly Asp Gly Glu Glu Gln Arg Val Val Ile Phe Glu Gln Thr Gln Tyr 
            180                 185                 190         


Asp Val Pro Ser Leu Ala Thr His Ser Ala Tyr Leu Lys Asp Asp Gln 
        195                 200                 205             


Arg Ser Thr Pro Asp Ser Thr Tyr Ser Glu Ser Phe Lys Asp Ala Ala 
    210                 215                 220                 


Thr Glu Lys Phe Arg Ser Ala Ser Val Gly Ala Glu Glu Tyr Met Tyr 
225                 230                 235                 240 


Asp Gln Thr Ser Ser Gly Thr Phe Gln Tyr Thr Leu Glu Ala Thr Lys 
                245                 250                 255     


Ser Leu Arg Gln Lys Gln Gly Glu Gly Pro Met Thr Tyr Leu Asn Lys 
            260                 265                 270         


Gly Gln Phe Tyr Ala Ile Thr Leu Ser Glu Thr Gly Asp Asn Lys Cys 
        275                 280                 285             


Phe Arg His Pro Ile Ser Lys Val Arg Ser Val Val Met Val Val Phe 
    290                 295                 300                 


Ser Glu Asp Lys Asn Arg Asp Glu Gln Leu Lys Tyr Trp Lys Tyr Trp 
305                 310                 315                 320 


His Ser Arg Gln His Thr Ala Lys Gln Arg Val Leu Asp Ile Ala Asp 
                325                 330                 335     


Tyr Lys Glu Ser Phe Asn Thr Ile Gly Asn Ile Glu Glu Ile Ala Tyr 
            340                 345                 350         


Asn Ala Val Ser Phe Thr Trp Asp Val Asn Glu Glu Ala Lys Ile Phe 
        355                 360                 365             


Ile Thr Val Asn Cys Leu Ser Thr Asp Phe Ser Ser Gln Lys Gly Val 
    370                 375                 380                 


Lys Gly Leu Pro Leu Met Ile Gln Ile Asp Thr Tyr Ser Tyr Asn Asn 
385                 390                 395                 400 


Arg Ser Asn Lys Pro Ile His Arg Ala Tyr Cys Gln Ile Lys Val Phe 
                405                 410                 415     


Cys Asp Lys Gly Ala Glu Arg Lys Ile Arg Asp Glu Glu Arg Lys Gln 
            420                 425                 430         


Asn Arg Lys Lys Gly Lys Gly Gln Ala Ser Gln Thr Gln Cys Asn Ser 
        435                 440                 445             


Ser Ser Asp Gly Lys Leu Ala Ala Ile Pro Leu Gln Lys Lys Ser Asp 
    450                 455                 460                 


Ile Thr Tyr Phe Lys Thr Met Pro Asp Leu His Ser Gln Pro Val Leu 
465                 470                 475                 480 


Phe Ile Pro Asp Val His Phe Ala Asn Leu Gln Arg Thr Gly Gln Val 
                485                 490                 495     


Tyr Tyr Asn Thr Asp Asp Glu Arg Glu Gly Gly Ser Val Leu Val Lys 
            500                 505                 510         


Arg Met Phe Arg Pro Met Glu Glu Glu Phe Gly Pro Val Pro Ser Lys 
        515                 520                 525             


Gln Met Lys Glu Glu Gly Thr Lys Arg Val Leu Leu Tyr Val Arg Lys 
    530                 535                 540                 


Glu Thr Asp Asp Val Phe Asp Ala Leu Met Leu Lys Ser Pro Thr Val 
545                 550                 555                 560 


Lys Gly Leu Met Glu Ala Ile Ser Glu Lys Tyr Gly Leu Pro Val Glu 
                565                 570                 575     


Lys Ile Ala Lys Leu Tyr Lys Lys Ser Lys Lys Gly Ile Leu Val Asn 
            580                 585                 590         


Met Asp Asp Asn Ile Ile Glu His Tyr Ser Asn Glu Asp Thr Phe Ile 
        595                 600                 605             


Leu Asn Met Glu Ser Met Val Glu Gly Phe Lys Val Thr Leu Met Glu 
    610                 615                 620                 


Ile 
625 


<210>  542
<211>  134
<212>  PRT
<213>  Homo sapiens

<400>  542

Met Ala Ala Thr Met Lys Lys Ala Ala Ala Glu Asp Val Asn Val Thr 
1               5                   10                  15      


Phe Glu Asp Gln Gln Lys Ile Asn Lys Phe Ala Arg Asn Thr Ser Arg 
            20                  25                  30          


Ile Thr Glu Leu Lys Glu Glu Ile Glu Val Lys Lys Lys Gln Leu Gln 
        35                  40                  45              


Asn Leu Glu Asp Ala Cys Asp Asp Ile Met Leu Ala Asp Asp Asp Cys 
    50                  55                  60                  


Leu Met Ile Pro Tyr Gln Ile Gly Asp Val Phe Ile Ser His Ser Gln 
65                  70                  75                  80  


Glu Glu Thr Gln Glu Met Leu Glu Glu Ala Lys Lys Asn Leu Gln Glu 
                85                  90                  95      


Glu Ile Asp Ala Leu Glu Ser Arg Val Glu Ser Ile Gln Arg Val Leu 
            100                 105                 110         


Ala Asp Leu Lys Val Gln Leu Tyr Ala Lys Phe Gly Ser Asn Ile Asn 
        115                 120                 125             


Leu Glu Ala Asp Glu Ser 
    130                 


<210>  543
<211>  253
<212>  PRT
<213>  Homo sapiens

<400>  543

Met Glu Pro Leu Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Lys 
1               5                   10                  15      


Gln Pro His Leu Ala Pro Leu Gln Met Asp Ala Arg Glu Lys Gln Gly 
            20                  25                  30          


Gln Gln Met Arg Glu Ala Gln Phe Leu Tyr Ala Gln Lys Leu Val Thr 
        35                  40                  45              


Gln Pro Thr Leu Leu Ser Ala Thr Ala Gly Arg Pro Ser Gly Ser Thr 
    50                  55                  60                  


Pro Leu Gly Pro Leu Ala Arg Val Pro Pro Thr Ala Ala Val Ala Gln 
65                  70                  75                  80  


Val Phe Glu Arg Gly Asn Met Asn Ser Glu Pro Glu Glu Glu Asp Gly 
                85                  90                  95      


Gly Leu Glu Asp Glu Asp Gly Asp Asp Glu Val Ala Glu Val Ala Glu 
            100                 105                 110         


Lys Glu Thr Gln Ala Ala Ser Lys Tyr Phe His Val Gln Lys Val Ala 
        115                 120                 125             


Arg Gln Asp Pro Arg Val Ala Pro Met Ser Asn Leu Leu Pro Ala Pro 
    130                 135                 140                 


Gly Leu Pro Pro His Gly Gln Gln Ala Lys Glu Asp His Thr Lys Asp 
145                 150                 155                 160 


Ala Ser Lys Ala Ser Pro Ser Val Ser Thr Ala Gly Gln Pro Asn Trp 
                165                 170                 175     


Asn Leu Asp Glu Gln Leu Lys Gln Asn Gly Gly Leu Ala Trp Ser Asp 
            180                 185                 190         


Asp Ala Asp Gly Gly Arg Gly Arg Glu Ile Ser Arg Asp Phe Ala Lys 
        195                 200                 205             


Leu Tyr Glu Leu Asp Gly Asp Pro Glu Arg Lys Glu Phe Leu Asp Asp 
    210                 215                 220                 


Leu Phe Val Phe Met Gln Lys Arg Gly Glu Cys Ala Ser Thr His His 
225                 230                 235                 240 


Ser Asn Ser Gly Asn Thr Asp Arg Val Pro Thr Val Cys 
                245                 250             


<210>  544
<211>  155
<212>  PRT
<213>  Homo sapiens

<400>  544

Met Gly Gly Asn Gly Ser Thr Cys Lys Pro Asp Thr Glu Arg Gln Gly 
1               5                   10                  15      


Thr Leu Ser Thr Ala Ala Pro Thr Thr Ser Pro Ala Pro Cys Leu Ser 
            20                  25                  30          


Asn His His Asn Lys Lys His Leu Ile Leu Ala Phe Cys Ala Gly Val 
        35                  40                  45              


Leu Leu Thr Leu Leu Leu Ile Ala Phe Ile Phe Leu Ile Ile Lys Ser 
    50                  55                  60                  


Tyr Arg Lys Tyr Arg Arg Glu Arg Leu Pro Ile Ser Pro Gly Pro Leu 
65                  70                  75                  80  


Leu Arg Trp Val Pro Leu Leu Ser Gly Thr Met Ala Asp His Ser Lys 
                85                  90                  95      


Pro Gln Ala Pro Asp Pro His Ser Asp Pro Pro Ala Lys Leu Ser Ser 
            100                 105                 110         


Ile Pro Gly Glu Ser Leu Thr Tyr Ala Ser Thr Thr Phe Lys Leu Ser 
        115                 120                 125             


Glu Glu Lys Ser Asn His Leu Ala Glu Asn His Ser Ala Asp Phe Asp 
    130                 135                 140                 


Pro Ile Val Tyr Ala Gln Ile Lys Val Thr Asn 
145                 150                 155 


<210>  545
<211>  531
<212>  PRT
<213>  Homo sapiens

<400>  545

Met Glu Leu Gln Ser Arg Pro Glu Ala Leu Ala Val Glu Leu Ala Arg 
1               5                   10                  15      


His Gln Asn Gly Asp Leu Lys Lys Gln Leu His Glu Arg Gln Pro Arg 
            20                  25                  30          


Ile Ala Ala Leu Ser Asp Lys Gln Ala Leu Gly Thr Ile Thr Ala Val 
        35                  40                  45              


Pro Val Thr Gly Pro Gln Val Ser Ser Leu Gln Arg Leu Ala Gly Gln 
    50                  55                  60                  


Gly Ala Ala Val Leu Pro Gln Val Arg Pro Lys Thr Leu Ile Pro Asp 
65                  70                  75                  80  


Ser Leu Pro Val Ala Pro Gly Arg Asp Arg Pro Pro Lys Gln Pro Pro 
                85                  90                  95      


Thr Phe Gln Lys Ala Thr Val Val Ser Val Lys Asn Pro Ser Pro Ala 
            100                 105                 110         


Leu Pro Thr Ala Asn Asn Thr Val Ser His Val Pro Ala Pro Gly Ser 
        115                 120                 125             


Gln Pro Gln Ala Leu Ala Glu Pro Ala Ala Leu Ala Ser Pro Leu Ser 
    130                 135                 140                 


Ser Ala Gly Val Ala Tyr Ala Ile Ile Ser Thr Ser Pro Ser Asn Ala 
145                 150                 155                 160 


Ala Ala Met Ala Pro Ser Thr Ala Val Ser Val Val Ser Asp Ser Ile 
                165                 170                 175     


Lys Val Gln Pro Leu Leu Ile Ser Ala Asp Asn Lys Pro Pro Pro Arg 
            180                 185                 190         


Leu Leu Ser Ser Pro His Pro Ala Thr His His Cys Pro Leu His Pro 
        195                 200                 205             


Ser Ser Leu Pro Leu Thr Pro Pro Ser Pro Ser Leu Ser Pro Ser Pro 
    210                 215                 220                 


Leu His Gly Ile Phe Gln Val Ile Ile Ile Gln Pro Gln Val Gln Thr 
225                 230                 235                 240 


Gln Pro Glu Ser Thr Ala Glu Ser Arg Pro Pro Thr Glu Glu Pro Ser 
                245                 250                 255     


Gln Gly Ala Gln Ala Thr Lys Lys Lys Lys Glu Asp Arg Pro Pro Thr 
            260                 265                 270         


Gln Glu Asn Pro Glu Lys Ile Ala Phe Met Val Ala Leu Gly Leu Val 
        275                 280                 285             


Thr Thr Glu His Leu Glu Glu Ile Gln Ser Lys Arg Gln Glu Arg Lys 
    290                 295                 300                 


Arg Arg Ser Thr Ala Asn Pro Ala Tyr Ser Gly Leu Leu Glu Thr Glu 
305                 310                 315                 320 


Arg Lys Arg Leu Ala Ser Asn Tyr Leu Asn Asn Pro Leu Phe Leu Thr 
                325                 330                 335     


Ala Arg Ala Asn Glu Asp Pro Cys Trp Lys Asn Glu Ile Thr His Asp 
            340                 345                 350         


Glu His Cys Ala Ala Cys Lys Arg Gly Ala Asn Leu Gln Pro Cys Gly 
        355                 360                 365             


Thr Cys Pro Gly Ala Tyr His Leu Ser Cys Leu Glu Pro Pro Leu Lys 
    370                 375                 380                 


Thr Ala Pro Lys Gly Val Trp Val Cys Pro Arg Cys Gln Gln Lys Ala 
385                 390                 395                 400 


Leu Lys Lys Asp Glu Gly Val Pro Trp Thr Gly Met Leu Ala Ile Val 
                405                 410                 415     


His Ser Tyr Val Thr His Lys Thr Val Lys Glu Glu Glu Lys Gln Lys 
            420                 425                 430         


Leu Leu Gln Arg Gly Ser Glu Leu Gln Asn Glu His Gln Gln Leu Glu 
        435                 440                 445             


Glu Arg Asp Arg Arg Leu Ala Ser Ala Val Gln Lys Cys Leu Glu Leu 
    450                 455                 460                 


Lys Thr Ser Leu Leu Ala Arg Gln Arg Gly Thr Gln Ser Ser Leu Asp 
465                 470                 475                 480 


Arg Leu Arg Ala Leu Leu Arg Leu Ile Gln Gly Glu Gln Leu Leu Gln 
                485                 490                 495     


Val Thr Met Thr Thr Thr Ser Pro Ala Pro Leu Leu Ala Gly Pro Trp 
            500                 505                 510         


Thr Lys Pro Ser Val Ala Ala Thr His Pro Thr Val Gln His Pro Gln 
        515                 520                 525             


Gly His Asn 
    530     


<210>  546
<211>  354
<212>  PRT
<213>  Homo sapiens

<400>  546

Met Cys Gly Arg Thr Ser Cys His Leu Pro Arg Asp Val Leu Thr Arg 
1               5                   10                  15      


Ala Cys Ala Tyr Gln Asp Arg Arg Gly Gln Gln Arg Leu Pro Glu Trp 
            20                  25                  30          


Arg Asp Pro Asp Lys Tyr Cys Pro Ser Tyr Asn Lys Ser Pro Gln Ser 
        35                  40                  45              


Asn Ser Pro Val Leu Leu Ser Arg Leu His Phe Asp Lys Asp Ala Asp 
    50                  55                  60                  


Ser Ser Glu Arg Ile Ile Ala Pro Met Arg Trp Gly Leu Val Pro Ser 
65                  70                  75                  80  


Trp Phe Lys Glu Ser Asp Pro Ser Lys Leu Gln Phe Asn Thr Thr Asn 
                85                  90                  95      


Cys Arg Ser Asp Thr Val Met Glu Lys Arg Ser Phe Lys Val Pro Leu 
            100                 105                 110         


Gly Lys Gly Arg Arg Cys Val Val Leu Ala Asp Gly Phe Tyr Glu Trp 
        115                 120                 125             


Gln Arg Cys Gln Gly Thr Asn Gln Arg Gln Pro Tyr Phe Ile Tyr Phe 
    130                 135                 140                 


Pro Gln Ile Lys Thr Glu Lys Ser Gly Ser Ile Gly Ala Ala Asp Ser 
145                 150                 155                 160 


Pro Glu Asn Trp Glu Lys Val Trp Asp Asn Trp Arg Leu Leu Thr Met 
                165                 170                 175     


Ala Gly Ile Phe Asp Cys Trp Glu Pro Pro Glu Gly Gly Asp Val Leu 
            180                 185                 190         


Tyr Ser Tyr Thr Ile Ile Thr Val Asp Ser Cys Lys Gly Leu Ser Asp 
        195                 200                 205             


Ile His His Arg Met Pro Ala Ile Leu Asp Gly Glu Glu Ala Val Ser 
    210                 215                 220                 


Lys Trp Leu Asp Phe Gly Glu Val Ser Thr Gln Glu Ala Leu Lys Leu 
225                 230                 235                 240 


Ile His Pro Thr Glu Asn Ile Thr Phe His Ala Val Ser Ser Val Val 
                245                 250                 255     


Asn Asn Ser Arg Asn Asn Thr Pro Glu Cys Leu Ala Pro Val Asp Leu 
            260                 265                 270         


Val Val Lys Lys Glu Leu Arg Ala Ser Gly Ser Ser Gln Arg Met Leu 
        275                 280                 285             


Gln Trp Leu Ala Thr Lys Ser Pro Lys Lys Glu Asp Ser Lys Thr Pro 
    290                 295                 300                 


Gln Lys Glu Glu Ser Asp Val Pro Gln Trp Ser Ser Gln Phe Leu Gln 
305                 310                 315                 320 


Lys Ser Pro Leu Pro Thr Lys Arg Gly Thr Ala Gly Leu Leu Glu Gln 
                325                 330                 335     


Trp Leu Lys Arg Glu Lys Glu Glu Glu Pro Val Ala Lys Arg Pro Tyr 
            340                 345                 350         


Ser Gln 
        


<210>  547
<211>  120
<212>  PRT
<213>  Homo sapiens

<400>  547

Met Trp Ala Ser Glu Leu Arg Gly Pro Gly Cys Ala Asp Ser Leu Asn 
1               5                   10                  15      


Ala Ala Leu Ala His Ser Pro Leu Arg Asn Arg Gln Cys Arg Gly Phe 
            20                  25                  30          


Pro Gly Gly Gly His Ser Ile Gln Pro Leu Tyr Thr Pro Arg Ala Pro 
        35                  40                  45              


Ala Ala Ala Pro Pro Pro Pro His Lys Met Ala Ala Pro Ile Glu Glu 
    50                  55                  60                  


Thr Ala Ala Ala Ser Pro Ala Pro Phe Cys Gly Arg Arg Glu Ile Cys 
65                  70                  75                  80  


Gln His Gly Lys Pro Leu Leu Arg Met His Pro Ser Leu Glu Thr Pro 
                85                  90                  95      


Leu Lys Gly Trp Ser Leu Gly Asp His Ile Lys Arg Lys Met Pro Thr 
            100                 105                 110         


Thr Ser Thr Thr Ser Thr Arg Phe 
        115                 120 


<210>  548
<211>  234
<212>  PRT
<213>  Homo sapiens

<400>  548

Met Pro His Arg Lys Glu Arg Pro Ser Gly Ser Ser Leu His Thr His 
1               5                   10                  15      


Gly Ser Thr Gly Thr Ala Glu Gly Gly Asn Met Ser Arg Leu Ser Leu 
            20                  25                  30          


Thr Arg Ser Pro Val Ser Pro Leu Ala Ala Gln Gly Ile Pro Leu Pro 
        35                  40                  45              


Ala Gln Leu Thr Lys Ser Asn Ala Pro Val His Ile Asp Val Gly Ser 
    50                  55                  60                  


His Met Tyr Thr Ser Ser Leu Ala Thr Leu Thr Lys Tyr Pro Asp Ser 
65                  70                  75                  80  


Arg Ile Ser Arg Leu Phe Asn Gly Thr Glu Pro Ile Val Leu Asp Ser 
                85                  90                  95      


Leu Lys Gln His Tyr Phe Ile Asp Arg Asp Gly Glu Ile Phe Arg Tyr 
            100                 105                 110         


Val Leu Ser Phe Leu Arg Thr Ser Lys Leu Leu Leu Pro Asp Asp Phe 
        115                 120                 125             


Lys Asp Phe Ser Leu Leu Tyr Glu Glu Ala Arg Tyr Tyr Gln Leu Gln 
    130                 135                 140                 


Pro Met Val Arg Glu Leu Glu Arg Trp Gln Gln Glu Gln Glu Gln Arg 
145                 150                 155                 160 


Arg Arg Ser Arg Ala Cys Asp Cys Leu Val Val Arg Val Thr Pro Asp 
                165                 170                 175     


Leu Gly Glu Arg Ile Ala Leu Ser Gly Glu Lys Ala Leu Ile Glu Glu 
            180                 185                 190         


Val Phe Pro Glu Thr Gly Asp Val Met Cys Asn Ser Val Asn Ala Gly 
        195                 200                 205             


Trp Asn Gln Asp Pro Thr His Val Ile Arg Phe Pro Leu Asn Gly Tyr 
    210                 215                 220                 


Cys Arg Leu Asn Ser Val Gln Asp Val Leu 
225                 230                 


<210>  549
<211>  180
<212>  PRT
<213>  Homo sapiens

<400>  549

Met Leu Cys Leu Leu Leu Thr Leu Gly Val Ala Leu Val Cys Gly Val 
1               5                   10                  15      


Pro Ala Met Asp Ile Pro Gln Thr Lys Gln Asp Leu Glu Leu Pro Lys 
            20                  25                  30          


Leu Ala Gly Thr Trp His Ser Met Ala Met Ala Thr Asn Asn Ile Ser 
        35                  40                  45              


Leu Met Ala Thr Leu Lys Ala Pro Leu Arg Val His Ile Thr Ser Leu 
    50                  55                  60                  


Leu Pro Thr Pro Glu Asp Asn Leu Glu Ile Val Leu His Arg Trp Glu 
65                  70                  75                  80  


Asn Asn Ser Cys Val Glu Lys Lys Val Leu Gly Glu Lys Thr Glu Asn 
                85                  90                  95      


Pro Lys Lys Phe Lys Ile Asn Tyr Thr Val Ala Asn Glu Ala Thr Leu 
            100                 105                 110         


Leu Asp Thr Asp Tyr Asp Asn Phe Leu Phe Leu Cys Leu Gln Asp Thr 
        115                 120                 125             


Thr Thr Pro Ile Gln Ser Met Met Cys Gln Tyr Leu Ala Arg Val Leu 
    130                 135                 140                 


Val Glu Asp Asp Glu Ile Met Gln Gly Phe Ile Arg Ala Phe Arg Pro 
145                 150                 155                 160 


Leu Pro Arg His Leu Trp Tyr Leu Leu Asp Leu Lys Gln Met Glu Glu 
                165                 170                 175     


Pro Cys Arg Phe 
            180 


<210>  550
<211>  407
<212>  PRT
<213>  Homo sapiens

<400>  550

Met Asn Asn Ser Gly Ala Asp Glu Ile Gly Lys Leu Phe Val Gly Gly 
1               5                   10                  15      


Leu Asp Trp Ser Thr Thr Gln Glu Thr Leu Arg Ser Tyr Phe Ser Gln 
            20                  25                  30          


Tyr Gly Glu Val Val Asp Cys Val Ile Met Lys Asp Lys Thr Thr Asn 
        35                  40                  45              


Gln Ser Arg Gly Phe Gly Phe Val Lys Phe Lys Asp Pro Asn Cys Val 
    50                  55                  60                  


Gly Thr Val Leu Ala Ser Arg Pro His Thr Leu Asp Gly Arg Asn Ile 
65                  70                  75                  80  


Asp Pro Lys Pro Cys Thr Pro Arg Gly Met Gln Pro Glu Arg Thr Arg 
                85                  90                  95      


Pro Lys Glu Gly Trp Gln Lys Gly Pro Arg Ser Asp Asn Ser Lys Ser 
            100                 105                 110         


Asn Lys Ile Phe Val Gly Gly Ile Pro His Asn Cys Gly Glu Thr Glu 
        115                 120                 125             


Leu Arg Glu Tyr Phe Lys Lys Phe Gly Val Val Thr Glu Val Val Met 
    130                 135                 140                 


Ile Tyr Asp Ala Glu Lys Gln Arg Pro Arg Gly Phe Gly Phe Ile Thr 
145                 150                 155                 160 


Phe Glu Asp Glu Gln Ser Val Asp Gln Ala Val Asn Met His Phe His 
                165                 170                 175     


Asp Ile Met Gly Lys Lys Val Glu Val Lys Arg Ala Glu Pro Arg Asp 
            180                 185                 190         


Ser Lys Ser Gln Ala Pro Gly Gln Pro Gly Ala Ser Gln Trp Gly Ser 
        195                 200                 205             


Arg Val Val Pro Asn Ala Ala Asn Gly Trp Ala Gly Gln Pro Pro Pro 
    210                 215                 220                 


Thr Trp Gln Gln Gly Tyr Gly Pro Gln Gly Met Trp Val Pro Ala Gly 
225                 230                 235                 240 


Gln Ala Ile Gly Gly Tyr Gly Pro Pro Pro Ala Gly Arg Gly Ala Pro 
                245                 250                 255     


Pro Pro Pro Pro Pro Phe Thr Ser Tyr Ile Val Ser Thr Pro Pro Gly 
            260                 265                 270         


Gly Phe Pro Pro Pro Gln Gly Phe Pro Gln Gly Tyr Gly Ala Pro Pro 
        275                 280                 285             


Gln Phe Ser Phe Gly Tyr Gly Pro Pro Pro Pro Pro Pro Asp Gln Phe 
    290                 295                 300                 


Ala Pro Pro Gly Val Pro Pro Pro Pro Ala Thr Pro Gly Ala Ala Pro 
305                 310                 315                 320 


Leu Ala Phe Pro Pro Pro Pro Ser Gln Ala Ala Pro Asp Met Ser Lys 
                325                 330                 335     


Pro Pro Thr Ala Gln Pro Asp Phe Pro Tyr Gly Gln Tyr Ala Gly Tyr 
            340                 345                 350         


Gly Gln Asp Leu Ser Gly Phe Gly Gln Gly Phe Ser Asp Pro Ser Gln 
        355                 360                 365             


Gln Pro Pro Ser Tyr Gly Gly Pro Ser Val Pro Gly Ser Gly Gly Pro 
    370                 375                 380                 


Pro Ala Gly Gly Ser Gly Phe Gly Arg Gly Gln Asn His Asn Val Gln 
385                 390                 395                 400 


Gly Phe His Pro Tyr Arg Arg 
                405         


<210>  551
<211>  318
<212>  PRT
<213>  Homo sapiens

<400>  551

Met Pro Asn Ile Lys Ile Phe Ser Gly Ser Ser His Gln Asp Leu Ser 
1               5                   10                  15      


Gln Lys Ile Ala Asp Arg Leu Gly Leu Glu Leu Gly Lys Val Val Thr 
            20                  25                  30          


Lys Lys Phe Ser Asn Gln Glu Thr Cys Val Glu Ile Gly Glu Ser Val 
        35                  40                  45              


Arg Gly Glu Asp Val Tyr Ile Val Gln Ser Gly Cys Gly Glu Ile Asn 
    50                  55                  60                  


Asp Asn Leu Met Glu Leu Leu Ile Met Ile Asn Ala Cys Lys Ile Ala 
65                  70                  75                  80  


Ser Ala Ser Arg Val Thr Ala Val Ile Pro Cys Phe Pro Tyr Ala Arg 
                85                  90                  95      


Gln Asp Lys Lys Asp Lys Ser Arg Ala Pro Ile Ser Ala Lys Leu Val 
            100                 105                 110         


Ala Asn Met Leu Ser Val Ala Gly Ala Asp His Ile Ile Thr Met Asp 
        115                 120                 125             


Leu His Ala Ser Gln Ile Gln Gly Phe Phe Asp Ile Pro Val Asp Asn 
    130                 135                 140                 


Leu Tyr Ala Glu Pro Ala Val Leu Lys Trp Ile Arg Glu Asn Ile Ser 
145                 150                 155                 160 


Glu Trp Arg Asn Cys Thr Ile Val Ser Pro Asp Ala Gly Gly Ala Lys 
                165                 170                 175     


Arg Val Thr Ser Ile Ala Asp Arg Leu Asn Val Asp Phe Ala Leu Ile 
            180                 185                 190         


His Lys Glu Arg Lys Lys Ala Asn Glu Val Asp Arg Met Val Leu Val 
        195                 200                 205             


Gly Asp Val Lys Asp Arg Val Ala Ile Leu Val Asp Asp Met Ala Asp 
    210                 215                 220                 


Thr Cys Gly Thr Ile Cys His Ala Ala Asp Lys Leu Leu Ser Ala Gly 
225                 230                 235                 240 


Ala Thr Arg Val Tyr Ala Ile Leu Thr His Gly Ile Phe Ser Gly Pro 
                245                 250                 255     


Ala Ile Ser Arg Ile Asn Asn Ala Cys Phe Glu Ala Val Val Val Thr 
            260                 265                 270         


Asn Thr Ile Pro Gln Glu Asp Lys Met Lys His Cys Ser Lys Ile Gln 
        275                 280                 285             


Val Ile Asp Ile Ser Met Ile Leu Ala Glu Ala Ile Arg Arg Thr His 
    290                 295                 300                 


Asn Gly Glu Ser Val Ser Tyr Leu Phe Ser His Val Pro Leu 
305                 310                 315             


<210>  552
<211>  398
<212>  PRT
<213>  Homo sapiens

<400>  552

Met Tyr Lys Tyr Lys Gln Lys Pro Lys Tyr Gln Val Arg Trp Lys Ile 
1               5                   10                  15      


Ile Glu Ser Tyr Glu Gly Asn Ser Tyr Thr Phe Ile Asp Pro Thr Gln 
            20                  25                  30          


Leu Pro Tyr Asn Glu Lys Trp Glu Phe Pro Arg Asn Asn Leu Gln Phe 
        35                  40                  45              


Gly Lys Thr Leu Gly Ala Gly Ala Phe Gly Lys Val Val Glu Ala Thr 
    50                  55                  60                  


Ala Phe Gly Leu Gly Lys Glu Asp Ala Val Leu Lys Val Ala Val Lys 
65                  70                  75                  80  


Met Leu Lys Ser Thr Ala His Ala Asp Glu Lys Glu Ala Leu Met Ser 
                85                  90                  95      


Glu Leu Lys Ile Met Ser His Leu Gly Gln His Glu Asn Ile Val Asn 
            100                 105                 110         


Leu Leu Gly Ala Cys Thr His Gly Gly Pro Val Leu Val Ile Thr Glu 
        115                 120                 125             


Tyr Cys Cys Tyr Gly Asp Leu Leu Asn Phe Leu Arg Arg Lys Ala Glu 
    130                 135                 140                 


Ala Met Leu Gly Pro Ser Leu Ser Pro Gly Gln Asp Pro Glu Gly Gly 
145                 150                 155                 160 


Val Asp Tyr Lys Asn Ile His Leu Glu Lys Lys Tyr Val Arg Arg Asp 
                165                 170                 175     


Ser Gly Phe Ser Ser Gln Gly Val Asp Thr Tyr Val Glu Met Arg Pro 
            180                 185                 190         


Val Ser Thr Ser Ser Asn Asp Ser Phe Ser Glu Gln Asp Leu Asp Lys 
        195                 200                 205             


Glu Asp Gly Arg Pro Leu Glu Leu Arg Asp Leu Leu His Phe Ser Ser 
    210                 215                 220                 


Gln Val Ala Gln Gly Met Ala Phe Leu Ala Ser Lys Asn Cys Ile His 
225                 230                 235                 240 


Arg Asp Val Ala Ala Arg Asn Val Leu Leu Thr Asn Gly His Val Ala 
                245                 250                 255     


Lys Ile Gly Asp Phe Gly Leu Ala Arg Asp Ile Met Asn Asp Ser Asn 
            260                 265                 270         


Tyr Ile Val Lys Gly Asn Ala Arg Leu Pro Val Lys Trp Met Ala Pro 
        275                 280                 285             


Glu Ser Ile Phe Asp Cys Val Tyr Thr Val Gln Ser Asp Val Trp Ser 
    290                 295                 300                 


Tyr Gly Ile Leu Leu Trp Glu Ile Phe Ser Leu Gly Leu Asn Pro Tyr 
305                 310                 315                 320 


Pro Gly Ile Leu Val Asn Ser Lys Phe Tyr Lys Leu Val Lys Asp Gly 
                325                 330                 335     


Tyr Gln Met Ala Gln Pro Ala Phe Ala Pro Lys Asn Ile Tyr Ser Ile 
            340                 345                 350         


Met Gln Ala Cys Trp Ala Leu Glu Pro Thr His Arg Pro Thr Phe Gln 
        355                 360                 365             


Gln Ile Cys Ser Phe Leu Lys Gly Val Glu Ala Cys Gln Leu Gly Thr 
    370                 375                 380                 


Asp Asp Tyr Asp Ile Pro Thr Thr His His His His His His 
385                 390                 395             


<210>  553
<211>  491
<212>  PRT
<213>  Homo sapiens

<400>  553

Met Pro Gly Ala Arg Asp Ala Leu Cys His Gln Ala Leu Gln Leu Leu 
1               5                   10                  15      


Ala Glu Leu Cys Ala Arg Gly Ala Leu Glu His Asp Ser Cys Gln Asp 
            20                  25                  30          


Phe Ile Tyr His Leu Arg Asp Arg Ala Arg Pro Arg Leu Arg Asp Pro 
        35                  40                  45              


Asp Ile Ser Val Ser Leu Leu Thr Leu Val Val Thr Ala Cys Gly Leu 
    50                  55                  60                  


Ala Leu Phe Gly Val Ser Leu Phe Val Ser Trp Lys Leu Cys Trp Val 
65                  70                  75                  80  


Pro Trp Arg Glu Arg Gly Leu Pro Ser Gly Ser Lys Asp Asn Asn Gln 
                85                  90                  95      


Glu Pro Leu Asn Tyr Met Asp Thr Glu Thr Asn Glu Gln Glu Asn Ser 
            100                 105                 110         


Glu Asp Phe Leu Asp Pro Pro Thr Pro Cys Pro Asp Ser Ser Met Lys 
        115                 120                 125             


Ile Ser His Thr Ser Pro Asp Ile Pro Leu Ser Thr Gln Thr Gly Ile 
    130                 135                 140                 


Gln Glu Asn Cys Ala His Gly Val Arg Val Gln Arg Gln Val Thr Glu 
145                 150                 155                 160 


Pro Thr Ser Ser Ala Arg His Asn Ser Ile Arg Arg Gln Leu Asn Leu 
                165                 170                 175     


Ser Asn Pro Asp Phe Asn Ile Gln Gln Leu Gln Lys Gln Glu Gln Leu 
            180                 185                 190         


Thr Gly Ile Gly Arg Ile Lys Pro Glu Leu Tyr Lys Gln Arg Ser Leu 
        195                 200                 205             


Asp Asn Asp Asp Gly Arg Arg Ser Asn Ser Lys Ala Cys Gly Lys Leu 
    210                 215                 220                 


Asn Phe Ile Leu Lys Tyr Asp Cys Asp Leu Glu Gln Leu Ile Val Lys 
225                 230                 235                 240 


Ile His Lys Ala Val Asn Leu Pro Ala Lys Asp Phe Ser Gly Thr Ser 
                245                 250                 255     


Asp Pro Tyr Val Lys Ile Tyr Leu Leu Pro Asp Arg Lys Thr Lys His 
            260                 265                 270         


Gln Thr Lys Val His Arg Lys Thr Leu Asn Pro Val Phe Asp Glu Val 
        275                 280                 285             


Phe Leu Phe Pro Val Pro Tyr Asn Asp Leu Glu Ala Arg Lys Leu His 
    290                 295                 300                 


Phe Ser Val Tyr Asp Phe Asp Arg Phe Ser Arg His Asp Leu Ile Gly 
305                 310                 315                 320 


Gln Val Val Val Asp His Phe Leu Asp Leu Ala Asp Phe Pro Arg Glu 
                325                 330                 335     


Cys Ile Leu Trp Lys Asp Ile Glu Tyr Val Thr Asn Asp Asn Val Asp 
            340                 345                 350         


Leu Gly Glu Leu Met Phe Ser Leu Cys Tyr Leu Pro Thr Ala Gly Arg 
        355                 360                 365             


Leu Thr Ile Thr Ile Ile Lys Ala Arg Asn Leu Lys Ala Met Asp Ile 
    370                 375                 380                 


Thr Gly Ala Ser Asp Pro Tyr Val Lys Val Ser Leu Met Cys Asp Gly 
385                 390                 395                 400 


Arg Arg Leu Lys Lys Arg Lys Thr Ser Thr Lys Arg Asn Thr Leu Asn 
                405                 410                 415     


Pro Val Tyr Asn Glu Ala Ile Val Phe Asp Val Pro Pro Glu Asn Ile 
            420                 425                 430         


Asp Gln Ile His Leu Ser Ile Ala Val Met Asp Tyr Asp Arg Val Gly 
        435                 440                 445             


His Asn Glu Ile Ile Gly Val Cys Gln Val Gly Asn Glu Ala Glu Arg 
    450                 455                 460                 


Leu Gly Arg Asp His Trp Ser Glu Met Leu Ser Tyr Pro Arg Lys Pro 
465                 470                 475                 480 


Ile Ala His Trp His Ser Leu Val Glu Lys Arg 
                485                 490     


<210>  554
<211>  301
<212>  PRT
<213>  Homo sapiens

<400>  554

Met Glu Thr Pro Glu Val Pro Val Gly Ser Leu Ile Asp Phe Gly Pro 
1               5                   10                  15      


Glu Ala Pro Thr Ser Ser Pro Leu Glu Ala Pro Pro Pro Val Leu Gln 
            20                  25                  30          


Asp Gly Asp Gly Ser Leu Gly Asp Gly Ala Ser Glu Ser Glu Thr Thr 
        35                  40                  45              


Glu Ser Ala Asp Ser Glu Asn Asp Met Gly Glu Ser Pro Ser His Pro 
    50                  55                  60                  


Ser Trp Asp Gln Asp Arg Arg Ser Ser Ser Asn Glu Ser Phe Ser Ser 
65                  70                  75                  80  


Asn Gln Ser Thr Glu Ser Thr Gln Asp Glu Glu Thr Leu Ala Leu Arg 
                85                  90                  95      


Asp Phe Met Arg Gly Tyr Val Glu Lys Ile Phe Ser Gly Gly Glu Asp 
            100                 105                 110         


Leu Asp Gln Glu Glu Lys Ala Lys Phe Gly Glu Tyr Cys Ser Ser Glu 
        115                 120                 125             


Asn Gly Lys Gly Arg Glu Trp Phe Ala Arg Tyr Val Ser Ala Gln Arg 
    130                 135                 140                 


Cys Asn Ser Lys Cys Val Ser Glu Ala Thr Phe Tyr Arg Leu Val Gln 
145                 150                 155                 160 


Ser Phe Ala Val Val Leu Phe Glu Cys His Gln Met Asp Asp Phe Gly 
                165                 170                 175     


Pro Ala Lys Asn Leu Met Thr Met Cys Phe Thr Tyr Tyr His Ile Gly 
            180                 185                 190         


Lys Pro Gln Leu Leu Pro Pro Glu Ser Arg Glu Lys Pro Ala Gly Ser 
        195                 200                 205             


Ile Asp Ser Tyr Leu Lys Ser Ala Asn Ser Trp Leu Ala Glu Lys Lys 
    210                 215                 220                 


Asp Ile Ala Glu Arg Leu Leu Lys Asn Thr Ser Ala Arg Thr Glu Asn 
225                 230                 235                 240 


Val Lys Gly Phe Phe Gly Gly Leu Glu Thr Lys Leu Lys Gly Pro Leu 
                245                 250                 255     


Ala Arg Arg Asn Glu Glu Asp Glu Asn Lys Pro Gln Glu Lys Arg Pro 
            260                 265                 270         


Arg Ala Val Thr Ala Tyr Ser Pro Glu Asp Glu Lys Lys Gly Glu Lys 
        275                 280                 285             


Ile Tyr Leu Tyr Thr His Leu Lys Gln Gln Pro Ile Trp 
    290                 295                 300     


<210>  555
<211>  426
<212>  PRT
<213>  Homo sapiens

<400>  555

Met Phe Gly Lys Arg Lys Lys Arg Val Glu Ile Ser Ala Pro Ser Asn 
1               5                   10                  15      


Phe Glu His Arg Val His Thr Gly Phe Asp Gln His Glu Gln Lys Phe 
            20                  25                  30          


Thr Gly Leu Pro Arg Gln Trp Gln Ser Leu Ile Glu Glu Ser Ala Arg 
        35                  40                  45              


Arg Pro Lys Pro Leu Val Asp Pro Ala Cys Ile Thr Ser Ile Gln Pro 
    50                  55                  60                  


Gly Ala Pro Lys Thr Ile Val Arg Gly Ser Lys Gly Ala Lys Asp Gly 
65                  70                  75                  80  


Ala Leu Thr Leu Leu Leu Asp Glu Phe Glu Asn Met Ser Val Thr Arg 
                85                  90                  95      


Ser Asn Ser Leu Arg Arg Asp Ser Pro Pro Pro Pro Ala Arg Ala Arg 
            100                 105                 110         


Gln Glu Asn Gly Met Pro Glu Lys Pro Pro Gly Pro Arg Ser Pro Gln 
        115                 120                 125             


Arg Glu Pro Gln Arg Val Ser His Glu Gln Phe Arg Ala Ala Leu Gln 
    130                 135                 140                 


Leu Val Val Asp Pro Gly Asp Pro Arg Ser Tyr Leu Asp Asn Phe Ile 
145                 150                 155                 160 


Lys Ile Gly Glu Gly Ser Thr Gly Ile Val Cys Ile Ala Thr Val Arg 
                165                 170                 175     


Ser Ser Gly Lys Leu Val Ala Val Lys Lys Met Asp Leu Arg Lys Gln 
            180                 185                 190         


Gln Arg Arg Glu Leu Leu Phe Asn Glu Val Val Ile Met Arg Asp Tyr 
        195                 200                 205             


Gln His Glu Asn Val Val Glu Met Tyr Asn Ser Tyr Leu Val Gly Asp 
    210                 215                 220                 


Glu Leu Trp Val Val Met Glu Phe Leu Glu Gly Gly Ala Leu Thr Asp 
225                 230                 235                 240 


Ile Val Thr His Thr Arg Met Asn Glu Glu Gln Ile Ala Ala Val Cys 
                245                 250                 255     


Leu Ala Val Leu Gln Ala Leu Ser Val Leu His Ala Gln Gly Val Ile 
            260                 265                 270         


His Arg Asp Ile Lys Ser Asp Ser Ile Leu Leu Thr His Asp Gly Arg 
        275                 280                 285             


Val Lys Leu Ser Asp Phe Gly Phe Cys Ala Gln Val Ser Lys Glu Val 
    290                 295                 300                 


Pro Arg Arg Lys Ser Leu Val Gly Thr Pro Tyr Trp Met Ala Pro Glu 
305                 310                 315                 320 


Leu Ile Ser Arg Leu Pro Tyr Gly Pro Glu Val Asp Ile Trp Ser Leu 
                325                 330                 335     


Gly Ile Met Val Ile Glu Met Val Asp Gly Glu Pro Pro Tyr Phe Asn 
            340                 345                 350         


Glu Pro Pro Leu Lys Ala Met Lys Met Ile Arg Asp Asn Leu Pro Pro 
        355                 360                 365             


Arg Leu Lys Asn Leu His Lys Val Ser Pro Ser Leu Lys Gly Phe Leu 
    370                 375                 380                 


Asp Arg Leu Leu Val Arg Asp Pro Ala Gln Arg Ala Thr Ala Ala Glu 
385                 390                 395                 400 


Leu Leu Lys His Pro Phe Leu Ala Lys Ala Gly Pro Pro Ala Ser Ile 
                405                 410                 415     


Val Pro Leu Met Arg Gln Asn Arg Thr Arg 
            420                 425     


<210>  556
<211>  475
<212>  PRT
<213>  Homo sapiens

<400>  556

Met Ala Ser Ala Ala Arg Leu Thr Met Met Trp Glu Glu Val Thr Cys 
1               5                   10                  15      


Pro Ile Cys Leu Asp Pro Phe Val Glu Pro Val Ser Ile Glu Cys Gly 
            20                  25                  30          


His Ser Phe Cys Gln Glu Cys Ile Ser Gln Val Gly Lys Gly Gly Gly 
        35                  40                  45              


Ser Val Cys Pro Val Cys Arg Gln Arg Phe Leu Leu Lys Asn Leu Arg 
    50                  55                  60                  


Pro Asn Arg Gln Leu Ala Asn Met Val Asn Asn Leu Lys Glu Ile Ser 
65                  70                  75                  80  


Gln Glu Ala Arg Glu Gly Thr Gln Gly Glu Arg Cys Ala Val His Gly 
                85                  90                  95      


Glu Arg Leu His Leu Phe Cys Glu Lys Asp Gly Lys Ala Leu Cys Trp 
            100                 105                 110         


Val Cys Ala Gln Ser Arg Lys His Arg Asp His Ala Met Val Pro Leu 
        115                 120                 125             


Glu Glu Ala Ala Gln Glu Tyr Gln Glu Lys Leu Gln Val Ala Leu Gly 
    130                 135                 140                 


Glu Leu Arg Arg Lys Gln Glu Leu Ala Glu Lys Leu Glu Val Glu Ile 
145                 150                 155                 160 


Ala Ile Lys Arg Ala Asp Trp Lys Lys Thr Val Glu Thr Gln Lys Ser 
                165                 170                 175     


Arg Ile His Ala Glu Phe Val Gln Gln Lys Asn Phe Leu Val Glu Glu 
            180                 185                 190         


Glu Gln Arg Gln Leu Gln Glu Leu Glu Lys Asp Glu Arg Glu Gln Leu 
        195                 200                 205             


Arg Ile Leu Gly Glu Lys Glu Ala Lys Leu Ala Gln Gln Ser Gln Ala 
    210                 215                 220                 


Leu Gln Glu Leu Ile Ser Glu Leu Asp Arg Arg Cys His Ser Ser Ala 
225                 230                 235                 240 


Leu Glu Leu Leu Gln Glu Val Ile Ile Val Leu Glu Arg Ser Glu Ser 
                245                 250                 255     


Trp Asn Leu Lys Asp Leu Asp Ile Thr Ser Pro Glu Leu Arg Ser Val 
            260                 265                 270         


Cys His Val Pro Gly Leu Lys Lys Met Leu Arg Thr Cys Ala Val His 
        275                 280                 285             


Ile Thr Leu Asp Pro Asp Thr Ala Asn Pro Trp Leu Ile Leu Ser Glu 
    290                 295                 300                 


Asp Arg Arg Gln Val Arg Leu Gly Asp Thr Gln Gln Ser Ile Pro Gly 
305                 310                 315                 320 


Asn Glu Glu Arg Phe Asp Ser Tyr Pro Met Val Leu Gly Ala Gln His 
                325                 330                 335     


Phe His Ser Gly Lys His Tyr Trp Glu Val Asp Val Thr Gly Lys Glu 
            340                 345                 350         


Ala Trp Asp Leu Gly Val Cys Arg Asp Ser Val Arg Arg Lys Gly His 
        355                 360                 365             


Phe Leu Leu Ser Ser Lys Ser Gly Phe Trp Thr Ile Trp Leu Trp Asn 
    370                 375                 380                 


Lys Gln Lys Tyr Glu Ala Gly Thr Tyr Pro Gln Thr Pro Leu His Leu 
385                 390                 395                 400 


Gln Val Pro Pro Cys Gln Val Gly Ile Phe Leu Asp Tyr Glu Ala Gly 
                405                 410                 415     


Met Val Ser Phe Tyr Asn Ile Thr Asp His Gly Ser Leu Ile Tyr Ser 
            420                 425                 430         


Phe Ser Glu Cys Ala Phe Thr Gly Pro Leu Arg Pro Phe Phe Ser Pro 
        435                 440                 445             


Gly Phe Asn Asp Gly Gly Lys Asn Thr Ala Pro Leu Thr Leu Cys Pro 
    450                 455                 460                 


Leu Asn Ile Gly Ser Gln Gly Ser Thr Asp Tyr 
465                 470                 475 


<210>  557
<211>  185
<212>  PRT
<213>  Homo sapiens

<400>  557

Met Thr Phe Lys Ile Leu Cys Ile Ser Cys Lys Arg Arg Ser Glu Thr 
1               5                   10                  15      


Asn Ala Glu Thr Phe Thr Glu Trp Thr Phe Arg Gln Lys Gly Thr Glu 
            20                  25                  30          


Glu Phe Val Lys Ile Leu Arg Tyr Glu Asn Glu Val Leu Gln Leu Glu 
        35                  40                  45              


Glu Asp Glu Arg Phe Glu Gly Arg Val Val Trp Asn Gly Ser Arg Gly 
    50                  55                  60                  


Thr Lys Asp Leu Gln Asp Leu Ser Ile Phe Ile Thr Asn Val Thr Tyr 
65                  70                  75                  80  


Asn His Ser Gly Asp Tyr Glu Cys His Val Tyr Arg Leu Leu Phe Phe 
                85                  90                  95      


Glu Asn Tyr Glu His Asn Thr Ser Val Val Lys Lys Ile His Ile Glu 
            100                 105                 110         


Val Val Asp Lys Ala Asn Arg Asp Met Ala Ser Ile Val Ser Glu Ile 
        115                 120                 125             


Met Met Tyr Val Leu Ile Val Val Leu Thr Ile Trp Leu Val Ala Glu 
    130                 135                 140                 


Met Ile Tyr Cys Tyr Lys Lys Ile Ala Ala Ala Thr Glu Thr Ala Ala 
145                 150                 155                 160 


Gln Glu Asn Ala Ser Glu Tyr Leu Ala Ile Thr Ser Glu Ser Lys Glu 
                165                 170                 175     


Asn Cys Thr Gly Val Gln Val Ala Glu 
            180                 185 


<210>  558
<211>  261
<212>  PRT
<213>  Homo sapiens

<400>  558

Met Ala Leu Asn Lys Asn His Ser Glu Gly Gly Gly Val Ile Val Asn 
1               5                   10                  15      


Asn Thr Glu Ser Ile Leu Met Ser Tyr Asp His Val Glu Leu Thr Phe 
            20                  25                  30          


Asn Asp Met Lys Asn Val Pro Glu Ala Phe Lys Gly Thr Lys Lys Gly 
        35                  40                  45              


Thr Val Tyr Leu Thr Pro Tyr Arg Val Ile Phe Leu Ser Lys Gly Lys 
    50                  55                  60                  


Asp Ala Met Gln Ser Phe Met Met Pro Phe Tyr Leu Met Lys Asp Cys 
65                  70                  75                  80  


Glu Ile Lys Gln Pro Val Phe Gly Ala Asn Tyr Ile Lys Gly Thr Val 
                85                  90                  95      


Lys Ala Glu Ala Gly Gly Gly Trp Glu Gly Ser Ala Ser Tyr Lys Leu 
            100                 105                 110         


Thr Phe Thr Ala Gly Gly Ala Ile Glu Phe Gly Gln Arg Met Leu Gln 
        115                 120                 125             


Val Ala Ser Gln Ala Ser Arg Gly Glu Val Pro Ser Gly Ala Tyr Gly 
    130                 135                 140                 


Tyr Ser Tyr Met Pro Ser Gly Ala Tyr Val Tyr Pro Pro Pro Val Ala 
145                 150                 155                 160 


Asn Gly Met Tyr Pro Cys Pro Pro Gly Tyr Pro Tyr Pro Pro Pro Pro 
                165                 170                 175     


Pro Glu Phe Tyr Pro Gly Pro Pro Met Met Asp Gly Ala Met Gly Tyr 
            180                 185                 190         


Val Gln Pro Pro Pro Pro Pro Tyr Pro Gly Pro Met Glu Pro Pro Val 
        195                 200                 205             


Ser Gly Pro Asp Val Pro Ser Thr Pro Ala Ala Glu Ala Lys Ala Ala 
    210                 215                 220                 


Glu Ala Ala Ala Ser Ala Tyr Tyr Asn Pro Gly Asn Pro His Asn Val 
225                 230                 235                 240 


Tyr Met Pro Thr Ser Gln Pro Pro Pro Pro Pro Tyr Tyr Pro Pro Glu 
                245                 250                 255     


Asp Lys Lys Thr Gln 
            260     


<210>  559
<211>  311
<212>  PRT
<213>  Homo sapiens

<400>  559

Met Leu Thr Lys Pro Leu Gln Gly Pro Pro Ala Pro Pro Gly Thr Pro 
1               5                   10                  15      


Thr Pro Pro Pro Gly Gly Lys Asp Arg Glu Ala Phe Glu Ala Glu Tyr 
            20                  25                  30          


Arg Leu Gly Pro Leu Leu Gly Lys Gly Gly Phe Gly Thr Val Phe Ala 
        35                  40                  45              


Gly His Arg Leu Thr Asp Arg Leu Gln Val Ala Ile Lys Val Ile Pro 
    50                  55                  60                  


Arg Asn Arg Val Leu Gly Trp Ser Pro Leu Ser Asp Ser Val Thr Cys 
65                  70                  75                  80  


Pro Leu Glu Val Ala Leu Leu Trp Lys Val Gly Ala Gly Gly Gly His 
                85                  90                  95      


Pro Gly Val Ile Arg Leu Leu Asp Trp Phe Glu Thr Gln Glu Gly Phe 
            100                 105                 110         


Met Leu Val Leu Glu Arg Pro Leu Pro Ala Gln Asp Leu Phe Asp Tyr 
        115                 120                 125             


Ile Thr Glu Lys Gly Pro Leu Gly Glu Gly Pro Ser Arg Cys Phe Phe 
    130                 135                 140                 


Gly Gln Val Val Ala Ala Ile Gln His Cys His Ser Arg Gly Val Val 
145                 150                 155                 160 


His Arg Asp Ile Lys Asp Glu Asn Ile Leu Ile Asp Leu Arg Arg Gly 
                165                 170                 175     


Cys Ala Lys Leu Ile Asp Phe Gly Ser Gly Ala Leu Leu His Asp Glu 
            180                 185                 190         


Pro Tyr Thr Asp Phe Asp Gly Thr Arg Val Tyr Ser Pro Pro Glu Trp 
        195                 200                 205             


Ile Ser Arg His Gln Tyr His Ala Leu Pro Ala Thr Val Trp Ser Leu 
    210                 215                 220                 


Gly Ile Leu Leu Tyr Asp Met Val Cys Gly Asp Ile Pro Phe Glu Arg 
225                 230                 235                 240 


Asp Gln Glu Ile Leu Glu Ala Glu Leu His Phe Pro Ala His Val Ser 
                245                 250                 255     


Pro Asp Cys Cys Ala Leu Ile Arg Arg Cys Leu Ala Pro Lys Pro Ser 
            260                 265                 270         


Ser Arg Pro Ser Leu Glu Glu Ile Leu Leu Asp Pro Trp Met Gln Thr 
        275                 280                 285             


Pro Ala Glu Asp Val Pro Leu Asn Pro Ser Lys Gly Gly Pro Ala Pro 
    290                 295                 300                 


Leu Ala Trp Ser Leu Leu Pro 
305                 310     


<210>  560
<211>  222
<212>  PRT
<213>  Homo sapiens

<400>  560

Met Glu Ile Pro Pro Thr Asn Tyr Pro Ala Ser Arg Ala Ala Leu Val 
1               5                   10                  15      


Ala Gln Asn Tyr Ile Asn Tyr Gln Gln Gly Thr Pro His Arg Val Phe 
            20                  25                  30          


Glu Val Gln Lys Val Lys Gln Ala Ser Met Glu Asp Ile Pro Gly Arg 
        35                  40                  45              


Gly His Lys Tyr His Leu Lys Phe Ala Val Glu Glu Ile Ile Gln Lys 
    50                  55                  60                  


Gln Val Lys Val Asn Cys Thr Ala Glu Val Leu Tyr Pro Ser Thr Gly 
65                  70                  75                  80  


Gln Glu Thr Ala Pro Glu Val Asn Phe Thr Phe Glu Gly Glu Thr Gly 
                85                  90                  95      


Lys Asn Pro Asp Glu Glu Asp Asn Thr Phe Tyr Gln Arg Leu Lys Ser 
            100                 105                 110         


Met Lys Glu Pro Leu Glu Ala Gln Asn Ile Pro Asp Asn Phe Gly Asn 
        115                 120                 125             


Val Ser Pro Glu Met Thr Leu Val Leu His Leu Ala Trp Val Ala Cys 
    130                 135                 140                 


Gly Tyr Ile Ile Trp Gln Asn Ser Thr Glu Asp Thr Trp Tyr Lys Met 
145                 150                 155                 160 


Val Lys Ile Gln Thr Val Lys Gln Val Gln Arg Asn Asp Asp Phe Ile 
                165                 170                 175     


Glu Leu Asp Tyr Thr Ile Leu Leu His Asn Ile Ala Ser Gln Glu Ile 
            180                 185                 190         


Ile Pro Trp Gln Met Gln Val Leu Trp His Pro Gln Tyr Gly Thr Lys 
        195                 200                 205             


Val Lys His Asn Ser Arg Leu Pro Lys Glu Val Gln Leu Glu 
    210                 215                 220         


<210>  561
<211>  125
<212>  PRT
<213>  Homo sapiens

<400>  561

Met Ser Ser Thr Leu Gly Lys Leu Ser Asn Gln Val Glu Glu Thr Leu 
1               5                   10                  15      


Pro Leu Leu Lys Lys Val Pro Ala Asn Tyr Phe His Ile Cys Ser Ala 
            20                  25                  30          


Ile Leu Met Gly Phe Ser Leu Ser Lys Ser Ala Thr Gln Val Ser Ala 
        35                  40                  45              


Ile His Met Asp Ser Lys Val Asp Asp His Leu Ile Arg Gly Thr Glu 
    50                  55                  60                  


Lys Ser Arg Leu Glu Pro Ala Thr Gln Leu Phe Gln Asn Thr Lys Lys 
65                  70                  75                  80  


Ile Arg Leu Glu Asp Thr Asn Gln Glu Asn Phe Thr Arg Ile Glu Gly 
                85                  90                  95      


Thr Gly Thr Gly Ser Leu Ser Gly Lys Ala Leu Gly Ser Val Val Tyr 
            100                 105                 110         


Val Lys Glu Ser Asp Gly Leu Glu Met Thr Asp Val Glu 
        115                 120                 125 


<210>  562
<211>  363
<212>  PRT
<213>  Homo sapiens

<400>  562

Met Phe Lys Arg His Lys Ser Leu Ala Ser Glu Arg Lys Arg Ala Leu 
1               5                   10                  15      


Leu Ser Gln Arg Ala Thr Arg Phe Ile Leu Lys Asp Asp Met Arg Asn 
            20                  25                  30          


Phe His Phe Leu Ser Lys Leu Val Leu Ser Ala Gly Pro Leu Arg Pro 
        35                  40                  45              


Thr Pro Ala Val Lys His Ser Lys Thr Thr His Phe Glu Ile Glu Ile 
    50                  55                  60                  


Phe Asp Ala Gln Thr Arg Lys Gln Ile Cys Ile Leu Asp Lys Val Thr 
65                  70                  75                  80  


Gln Ser Ser Thr Ile His Asp Val Lys Gln Lys Phe His Lys Ala Cys 
                85                  90                  95      


Pro Lys Trp Tyr Pro Ser Arg Val Gly Leu Gln Leu Glu Cys Gly Gly 
            100                 105                 110         


Pro Phe Leu Lys Asp Tyr Ile Thr Ile Gln Ser Ile Ala Ala Ser Ser 
        115                 120                 125             


Ile Val Thr Leu Tyr Ala Thr Asp Leu Gly Gln Gln Val Ser Trp Thr 
    130                 135                 140                 


Thr Val Phe Leu Ala Glu Tyr Thr Gly Pro Leu Leu Ile Tyr Leu Leu 
145                 150                 155                 160 


Phe Tyr Leu Arg Ile Pro Cys Ile Tyr Asp Gly Lys Glu Ser Ala Arg 
                165                 170                 175     


Arg Leu Arg His Pro Val Val His Leu Ala Cys Phe Cys His Cys Ile 
            180                 185                 190         


His Tyr Ile Arg Tyr Leu Leu Glu Thr Leu Phe Val His Lys Val Ser 
        195                 200                 205             


Ala Gly His Thr Pro Leu Lys Asn Leu Ile Met Ser Cys Ala Phe Tyr 
    210                 215                 220                 


Trp Gly Phe Thr Ser Trp Ile Ala Tyr Tyr Ile Asn His Pro Leu Tyr 
225                 230                 235                 240 


Thr Pro Pro Ser Phe Gly Asn Arg Gln Ile Thr Val Ser Ala Ile Asn 
                245                 250                 255     


Phe Leu Ile Cys Glu Ala Gly Asn His Phe Ile Asn Val Met Leu Ser 
            260                 265                 270         


His Pro Asn His Thr Gly Asn Asn Ala Cys Phe Pro Ser Pro Asn Tyr 
        275                 280                 285             


Asn Pro Phe Thr Trp Met Phe Phe Leu Val Ser Cys Pro Asn Tyr Thr 
    290                 295                 300                 


Tyr Glu Ile Gly Ser Trp Ile Ser Phe Thr Val Met Thr Gln Thr Leu 
305                 310                 315                 320 


Pro Val Gly Ile Phe Thr Leu Leu Met Ser Ile Gln Met Ser Leu Trp 
                325                 330                 335     


Ala Gln Lys Lys His Lys Ile Tyr Leu Arg Lys Phe Asn Ser Tyr Ile 
            340                 345                 350         


His Arg Lys Ser Ala Met Ile Pro Phe Ile Leu 
        355                 360             


<210>  563
<211>  436
<212>  PRT
<213>  Homo sapiens

<400>  563

Met Asp Asn Leu Glu Lys Gln Leu Ile Cys Pro Ile Cys Leu Glu Met 
1               5                   10                  15      


Phe Thr Lys Pro Val Val Ile Leu Pro Cys Gln His Asn Leu Cys Arg 
            20                  25                  30          


Lys Cys Ala Ser Asp Ile Phe Gln Ala Ser Asn Pro Tyr Leu Pro Thr 
        35                  40                  45              


Arg Gly Gly Thr Thr Met Ala Ser Gly Gly Arg Phe Arg Cys Pro Ser 
    50                  55                  60                  


Cys Arg His Glu Val Val Leu Asp Arg His Gly Val Tyr Gly Leu Gln 
65                  70                  75                  80  


Arg Asn Leu Leu Val Glu Asn Ile Ile Asp Ile Tyr Lys Gln Glu Ser 
                85                  90                  95      


Thr Arg Pro Glu Lys Lys Ser Asp Gln Pro Met Cys Glu Glu His Glu 
            100                 105                 110         


Glu Glu Arg Ile Asn Ile Tyr Cys Leu Asn Cys Glu Val Pro Thr Cys 
        115                 120                 125             


Ser Leu Cys Lys Val Phe Gly Ala His Lys Asp Cys Gln Val Ala Pro 
    130                 135                 140                 


Leu Thr His Val Phe Gln Arg Gln Lys Ser Glu Leu Ser Asp Gly Ile 
145                 150                 155                 160 


Ala Ile Leu Val Gly Ser Asn Asp Arg Val Gln Gly Val Ile Ser Gln 
                165                 170                 175     


Leu Glu Asp Thr Cys Lys Thr Ile Glu Glu Cys Cys Arg Lys Gln Lys 
            180                 185                 190         


Gln Glu Leu Cys Glu Lys Phe Asp Tyr Leu Tyr Gly Ile Leu Glu Glu 
        195                 200                 205             


Arg Lys Asn Glu Met Thr Gln Val Ile Thr Arg Thr Gln Glu Glu Lys 
    210                 215                 220                 


Leu Glu His Val Arg Ala Leu Ile Lys Lys Tyr Ser Asp His Leu Glu 
225                 230                 235                 240 


Asn Val Ser Lys Leu Val Glu Ser Gly Ile Gln Phe Met Asp Glu Pro 
                245                 250                 255     


Glu Met Ala Val Phe Leu Gln Asn Ala Lys Thr Leu Leu Lys Lys Ile 
            260                 265                 270         


Ser Glu Ala Ser Lys Ala Phe Gln Met Glu Lys Ile Glu His Gly Tyr 
        275                 280                 285             


Glu Asn Met Asn His Phe Thr Val Asn Leu Asn Arg Glu Glu Lys Ile 
    290                 295                 300                 


Ile Arg Glu Ile Asp Phe Tyr Arg Glu Asp Glu Asp Glu Glu Glu Glu 
305                 310                 315                 320 


Glu Gly Gly Glu Gly Glu Lys Glu Gly Glu Gly Glu Val Gly Gly Glu 
                325                 330                 335     


Ala Val Glu Val Glu Glu Val Glu Asn Val Gln Thr Glu Phe Pro Gly 
            340                 345                 350         


Glu Asp Glu Asn Pro Glu Lys Ala Ser Glu Leu Ser Gln Val Glu Leu 
        355                 360                 365             


Gln Ala Ala Pro Gly Ala Leu Pro Val Ser Ser Pro Glu Pro Pro Pro 
    370                 375                 380                 


Ala Leu Pro Pro Ala Ala Asp Ala Pro Val Thr Gln Ile Gly Phe Glu 
385                 390                 395                 400 


Ala Pro Pro Leu Gln Gly Gln Ala Ala Ala Pro Ala Ser Gly Ser Gly 
                405                 410                 415     


Ala Asp Ser Glu Pro Ala Arg His Ile Phe Ser Phe Ser Trp Leu Asn 
            420                 425                 430         


Ser Leu Asn Glu 
        435     


<210>  564
<211>  365
<212>  PRT
<213>  Homo sapiens

<400>  564

Met Ser Leu Ile Arg Lys Lys Gly Phe Tyr Lys Gln Asp Val Asn Lys 
1               5                   10                  15      


Thr Ala Trp Glu Leu Pro Lys Thr Tyr Val Ser Pro Thr His Val Gly 
            20                  25                  30          


Ser Gly Ala Tyr Gly Ser Val Cys Ser Ala Ile Asp Lys Arg Ser Gly 
        35                  40                  45              


Glu Lys Val Ala Ile Lys Lys Leu Ser Arg Pro Phe Gln Ser Glu Ile 
    50                  55                  60                  


Phe Ala Lys Arg Ala Tyr Arg Glu Leu Leu Leu Leu Lys His Met Gln 
65                  70                  75                  80  


His Glu Asn Val Ile Gly Leu Leu Asp Val Phe Thr Pro Ala Ser Ser 
                85                  90                  95      


Leu Arg Asn Phe Tyr Asp Phe Tyr Leu Val Met Pro Phe Met Gln Thr 
            100                 105                 110         


Asp Leu Gln Lys Ile Met Gly Met Glu Phe Ser Glu Glu Lys Ile Gln 
        115                 120                 125             


Tyr Leu Val Tyr Gln Met Leu Lys Gly Leu Lys Tyr Ile His Ser Ala 
    130                 135                 140                 


Gly Val Val His Arg Asp Leu Lys Pro Gly Asn Leu Ala Val Asn Glu 
145                 150                 155                 160 


Asp Cys Glu Leu Lys Ile Leu Asp Phe Gly Leu Ala Arg His Ala Asp 
                165                 170                 175     


Ala Glu Met Thr Gly Tyr Val Val Thr Arg Trp Tyr Arg Ala Pro Glu 
            180                 185                 190         


Val Ile Leu Ser Trp Met His Tyr Asn Gln Thr Val Asp Ile Trp Ser 
        195                 200                 205             


Val Gly Cys Ile Met Ala Glu Met Leu Thr Gly Lys Thr Leu Phe Lys 
    210                 215                 220                 


Gly Lys Asp Tyr Leu Asp Gln Leu Thr Gln Ile Leu Lys Val Thr Gly 
225                 230                 235                 240 


Val Pro Gly Thr Glu Phe Val Gln Lys Leu Asn Asp Lys Ala Ala Lys 
                245                 250                 255     


Ser Tyr Ile Gln Ser Leu Pro Gln Thr Pro Arg Lys Asp Phe Thr Gln 
            260                 265                 270         


Leu Phe Pro Arg Ala Ser Pro Gln Ala Ala Asp Leu Leu Glu Lys Met 
        275                 280                 285             


Leu Glu Leu Asp Val Asp Lys Arg Leu Thr Ala Ala Gln Ala Leu Thr 
    290                 295                 300                 


His Pro Phe Phe Glu Pro Phe Arg Asp Pro Glu Glu Glu Thr Glu Ala 
305                 310                 315                 320 


Gln Gln Pro Phe Asp Asp Ser Leu Glu His Glu Lys Leu Thr Val Asp 
                325                 330                 335     


Glu Trp Lys Gln His Ile Tyr Lys Glu Ile Val Asn Phe Ser Pro Ile 
            340                 345                 350         


Ala Arg Lys Asp Ser Arg Arg Arg Ser Gly Met Lys Leu 
        355                 360                 365 


<210>  565
<211>  858
<212>  PRT
<213>  Homo sapiens

<400>  565

Met Ser Val Val Gly Leu Asp Val Gly Ser Gln Ser Cys Tyr Ile Ala 
1               5                   10                  15      


Val Ala Arg Ala Gly Gly Ile Glu Thr Ile Ala Asn Glu Phe Ser Asp 
            20                  25                  30          


Arg Cys Thr Pro Ser Val Ile Ser Phe Gly Ser Lys Asn Arg Thr Ile 
        35                  40                  45              


Gly Val Ala Ala Lys Asn Gln Gln Ile Thr His Ala Asn Asn Thr Val 
    50                  55                  60                  


Ser Asn Phe Lys Arg Phe His Gly Arg Ala Phe Asn Asp Pro Phe Ile 
65                  70                  75                  80  


Gln Lys Glu Lys Glu Asn Leu Ser Tyr Asp Leu Val Pro Leu Lys Asn 
                85                  90                  95      


Gly Gly Val Gly Ile Lys Val Met Tyr Met Gly Glu Glu His Leu Phe 
            100                 105                 110         


Ser Val Glu Gln Ile Thr Ala Met Leu Leu Thr Lys Leu Lys Glu Thr 
        115                 120                 125             


Ala Glu Asn Ser Leu Lys Lys Pro Val Thr Asp Cys Val Ile Ser Val 
    130                 135                 140                 


Pro Ser Phe Phe Thr Asp Ala Glu Arg Arg Ser Val Leu Asp Ala Ala 
145                 150                 155                 160 


Gln Ile Val Gly Leu Asn Cys Leu Arg Leu Met Asn Asp Met Thr Ala 
                165                 170                 175     


Val Ala Leu Asn Tyr Gly Ile Tyr Lys Gln Asp Leu Pro Ser Leu Asp 
            180                 185                 190         


Glu Lys Pro Arg Ile Val Val Phe Val Asp Met Gly His Ser Ala Phe 
        195                 200                 205             


Gln Val Ser Ala Cys Ala Phe Asn Lys Gly Lys Leu Lys Val Leu Gly 
    210                 215                 220                 


Thr Ala Phe Asp Pro Phe Leu Gly Gly Lys Asn Phe Asp Glu Lys Leu 
225                 230                 235                 240 


Val Glu His Phe Cys Ala Glu Phe Lys Thr Lys Tyr Lys Leu Asp Ala 
                245                 250                 255     


Lys Ser Lys Ile Arg Ala Leu Leu Arg Leu Tyr Gln Glu Cys Glu Lys 
            260                 265                 270         


Leu Lys Lys Leu Met Ser Ser Asn Ser Thr Asp Leu Pro Leu Asn Ile 
        275                 280                 285             


Glu Cys Phe Met Asn Asp Lys Asp Val Ser Gly Lys Met Asn Arg Ser 
    290                 295                 300                 


Gln Phe Glu Glu Leu Cys Ala Glu Leu Leu Gln Lys Ile Glu Val Pro 
305                 310                 315                 320 


Leu Tyr Ser Leu Leu Glu Gln Thr His Leu Lys Val Glu Asp Val Ser 
                325                 330                 335     


Ala Val Glu Ile Val Gly Gly Ala Thr Arg Ile Pro Ala Val Lys Glu 
            340                 345                 350         


Arg Ile Ala Lys Phe Phe Gly Lys Asp Ile Ser Thr Thr Leu Asn Ala 
        355                 360                 365             


Asp Glu Ala Val Ala Arg Gly Cys Ala Leu Gln Cys Ala Ile Leu Ser 
    370                 375                 380                 


Pro Ala Phe Lys Val Arg Glu Phe Ser Val Thr Asp Ala Val Pro Phe 
385                 390                 395                 400 


Pro Ile Ser Leu Ile Trp Asn His Asp Ser Glu Asp Thr Glu Gly Val 
                405                 410                 415     


His Glu Val Phe Ser Arg Asn His Ala Ala Pro Phe Ser Lys Val Leu 
            420                 425                 430         


Thr Phe Leu Arg Arg Gly Pro Phe Glu Leu Glu Ala Phe Tyr Ser Asp 
        435                 440                 445             


Pro Gln Gly Val Pro Tyr Pro Glu Ala Lys Ile Gly Arg Phe Val Val 
    450                 455                 460                 


Gln Asn Val Ser Ala Gln Lys Asp Gly Glu Lys Ser Arg Val Lys Val 
465                 470                 475                 480 


Lys Val Arg Val Asn Thr His Gly Ile Phe Thr Ile Ser Thr Ala Ser 
                485                 490                 495     


Met Val Glu Lys Val Pro Thr Glu Glu Asn Glu Met Ser Ser Glu Ala 
            500                 505                 510         


Asp Met Glu Cys Leu Asn Gln Arg Pro Pro Glu Asn Pro Asp Thr Asp 
        515                 520                 525             


Lys Asn Val Gln Gln Asp Asn Ser Glu Ala Gly Thr Gln Pro Gln Val 
    530                 535                 540                 


Gln Thr Asp Ala Gln Gln Thr Ser Gln Ser Pro Pro Ser Pro Glu Leu 
545                 550                 555                 560 


Thr Ser Glu Glu Asn Lys Ile Pro Asp Ala Asp Lys Ala Asn Glu Lys 
                565                 570                 575     


Lys Val Asp Gln Pro Pro Glu Ala Lys Lys Pro Lys Ile Lys Val Val 
            580                 585                 590         


Asn Val Glu Leu Pro Ile Glu Ala Asn Leu Val Trp Gln Leu Gly Lys 
        595                 600                 605             


Asp Leu Leu Asn Met Tyr Ile Glu Thr Glu Gly Lys Met Ile Met Gln 
    610                 615                 620                 


Asp Lys Leu Glu Lys Glu Arg Asn Asp Ala Lys Asn Ala Val Glu Glu 
625                 630                 635                 640 


Tyr Val Tyr Glu Phe Arg Asp Lys Leu Cys Gly Pro Tyr Glu Lys Phe 
                645                 650                 655     


Ile Cys Glu Gln Asp His Gln Asn Phe Leu Arg Leu Leu Thr Glu Thr 
            660                 665                 670         


Glu Asp Trp Leu Tyr Glu Glu Gly Glu Asp Gln Ala Lys Gln Ala Tyr 
        675                 680                 685             


Val Asp Lys Leu Glu Glu Leu Met Lys Ile Gly Thr Pro Val Lys Val 
    690                 695                 700                 


Arg Phe Gln Glu Ala Glu Glu Arg Pro Lys Met Phe Glu Glu Leu Gly 
705                 710                 715                 720 


Gln Arg Leu Gln His Tyr Ala Lys Ile Ala Ala Asp Phe Arg Asn Lys 
                725                 730                 735     


Asp Glu Lys Tyr Asn His Ile Asp Glu Ser Glu Met Lys Lys Val Glu 
            740                 745                 750         


Lys Ser Val Asn Glu Val Met Glu Trp Met Asn Asn Val Met Asn Ala 
        755                 760                 765             


Gln Ala Lys Lys Ser Leu Asp Gln Asp Pro Val Val Arg Ala Gln Glu 
    770                 775                 780                 


Ile Lys Thr Lys Ile Lys Glu Leu Asn Asn Thr Cys Glu Pro Val Val 
785                 790                 795                 800 


Thr Gln Pro Lys Pro Lys Ile Glu Ser Pro Lys Leu Glu Arg Thr Pro 
                805                 810                 815     


Asn Gly Pro Asn Ile Asp Lys Lys Glu Glu Asp Leu Glu Asp Lys Asn 
            820                 825                 830         


Asn Phe Gly Ala Glu Pro Pro His Gln Asn Gly Glu Cys Tyr Pro Asn 
        835                 840                 845             


Glu Lys Asn Ser Val Asn Met Asp Leu Asp 
    850                 855             


<210>  566
<211>  434
<212>  PRT
<213>  Homo sapiens

<400>  566

Met Ala Met Gln Lys Ile Phe Ala Arg Glu Ile Leu Asp Ser Arg Gly 
1               5                   10                  15      


Asn Pro Thr Val Glu Val Asp Leu His Thr Ala Lys Gly Arg Phe Arg 
            20                  25                  30          


Ala Ala Val Pro Ser Gly Ala Ser Thr Gly Ile Tyr Glu Ala Leu Glu 
        35                  40                  45              


Leu Arg Asp Gly Asp Lys Gly Arg Tyr Leu Gly Lys Gly Val Leu Lys 
    50                  55                  60                  


Ala Val Glu Asn Ile Asn Ser Thr Leu Gly Pro Ala Leu Leu Gln Lys 
65                  70                  75                  80  


Lys Leu Ser Val Ala Asp Gln Glu Lys Val Asp Lys Phe Met Ile Glu 
                85                  90                  95      


Leu Asp Gly Thr Glu Asn Lys Ser Lys Phe Gly Ala Asn Ala Ile Leu 
            100                 105                 110         


Gly Val Ser Leu Ala Val Cys Lys Ala Gly Ala Ala Glu Lys Gly Val 
        115                 120                 125             


Pro Leu Tyr Arg His Ile Ala Asp Leu Ala Gly Asn Pro Asp Leu Ile 
    130                 135                 140                 


Leu Pro Val Pro Ala Phe Asn Val Ile Asn Gly Gly Ser His Ala Gly 
145                 150                 155                 160 


Asn Lys Leu Ala Met Gln Glu Phe Met Ile Leu Pro Val Gly Ala Ser 
                165                 170                 175     


Ser Phe Lys Glu Ala Met Arg Ile Gly Ala Glu Val Tyr His His Leu 
            180                 185                 190         


Lys Gly Val Ile Lys Ala Lys Tyr Gly Lys Asp Ala Thr Asn Val Gly 
        195                 200                 205             


Asp Glu Gly Gly Phe Ala Pro Asn Ile Leu Glu Asn Asn Glu Ala Leu 
    210                 215                 220                 


Glu Leu Leu Lys Thr Ala Ile Gln Ala Ala Gly Tyr Pro Asp Lys Val 
225                 230                 235                 240 


Val Ile Gly Met Asp Val Ala Ala Ser Glu Phe Tyr Arg Asn Gly Lys 
                245                 250                 255     


Tyr Asp Leu Asp Phe Lys Ser Pro Asp Asp Pro Ala Arg His Ile Thr 
            260                 265                 270         


Gly Glu Lys Leu Gly Glu Leu Tyr Lys Ser Phe Ile Lys Asn Tyr Pro 
        275                 280                 285             


Val Val Ser Ile Glu Asp Pro Phe Asp Gln Asp Asp Trp Ala Thr Trp 
    290                 295                 300                 


Thr Ser Phe Leu Ser Gly Val Asn Ile Gln Ile Val Gly Asp Asp Leu 
305                 310                 315                 320 


Thr Val Thr Asn Pro Lys Arg Ile Ala Gln Ala Val Glu Lys Lys Ala 
                325                 330                 335     


Cys Asn Cys Leu Leu Leu Lys Val Asn Gln Ile Gly Ser Val Thr Glu 
            340                 345                 350         


Ser Ile Gln Ala Cys Lys Leu Ala Gln Ser Asn Gly Trp Gly Val Met 
        355                 360                 365             


Val Ser His Arg Ser Gly Glu Thr Glu Asp Thr Phe Ile Ala Asp Leu 
    370                 375                 380                 


Val Val Gly Leu Cys Thr Gly Gln Ile Lys Thr Gly Ala Pro Cys Arg 
385                 390                 395                 400 


Ser Glu Arg Leu Ala Lys Tyr Asn Gln Leu Met Arg Ile Glu Glu Ala 
                405                 410                 415     


Leu Gly Asp Lys Ala Ile Phe Ala Gly Arg Lys Phe Arg Asn Pro Lys 
            420                 425                 430         


Ala Lys 
        


<210>  567
<211>  153
<212>  PRT
<213>  Homo sapiens

<400>  567

Met Asn Val Gly Thr Ala His Ser Glu Val Asn Pro Asn Thr Arg Val 
1               5                   10                  15      


Met Asn Ser Arg Gly Ile Trp Leu Ser Tyr Val Leu Ala Ile Gly Leu 
            20                  25                  30          


Leu His Ile Val Leu Leu Ser Ile Pro Phe Val Ser Val Pro Val Val 
        35                  40                  45              


Trp Thr Leu Thr Asn Leu Ile His Asn Met Gly Met Tyr Ile Phe Leu 
    50                  55                  60                  


His Thr Val Lys Gly Thr Pro Phe Glu Thr Pro Asp Gln Gly Lys Ala 
65                  70                  75                  80  


Arg Leu Leu Thr His Trp Glu Gln Met Asp Tyr Gly Val Gln Phe Thr 
                85                  90                  95      


Ala Ser Arg Lys Phe Leu Thr Ile Thr Pro Ile Val Leu Tyr Phe Leu 
            100                 105                 110         


Thr Ser Phe Tyr Thr Lys Tyr Asp Gln Ile His Phe Val Leu Asn Thr 
        115                 120                 125             


Val Ser Leu Met Ser Val Leu Ile Pro Lys Leu Pro Gln Leu His Gly 
    130                 135                 140                 


Val Arg Ile Phe Gly Ile Asn Lys Tyr 
145                 150             


<210>  568
<211>  444
<212>  PRT
<213>  Homo sapiens

<400>  568

Met Glu Pro Pro Gly Pro Val Arg Gly Pro Leu Gln Asp Ser Ser Trp 
1               5                   10                  15      


Tyr Glu Pro Ser Ala Glu Leu Val Gln Thr Arg Met Ala Val Ser Leu 
            20                  25                  30          


Thr Ala Ala Glu Thr Leu Ala Leu Gln Gly Thr Gln Gly Gln Glu Lys 
        35                  40                  45              


Met Met Met Met Gly Pro Lys Glu Glu Glu Gln Ser Cys Glu Tyr Glu 
    50                  55                  60                  


Thr Arg Leu Pro Gly Asn His Ser Thr Ser Gln Glu Ile Phe Arg Gln 
65                  70                  75                  80  


Arg Phe Arg His Leu Arg Tyr Gln Glu Thr Pro Gly Pro Arg Glu Ala 
                85                  90                  95      


Leu Ser Gln Leu Arg Val Leu Cys Cys Glu Trp Leu Arg Pro Glu Lys 
            100                 105                 110         


His Thr Lys Glu Gln Ile Leu Glu Phe Leu Val Leu Glu Gln Phe Leu 
        115                 120                 125             


Thr Ile Leu Pro Glu Glu Leu Gln Ser Trp Val Arg Gly His His Pro 
    130                 135                 140                 


Lys Ser Gly Glu Glu Ala Val Thr Val Leu Glu Asp Leu Glu Lys Gly 
145                 150                 155                 160 


Leu Glu Pro Glu Pro Gln Val Pro Gly Pro Ala His Gly Pro Ala Gln 
                165                 170                 175     


Glu Glu Pro Trp Glu Lys Lys Glu Ser Leu Gly Ala Ala Gln Glu Ala 
            180                 185                 190         


Leu Ser Ile Gln Leu Gln Pro Lys Glu Thr Gln Pro Phe Pro Lys Ser 
        195                 200                 205             


Glu Gln Val Tyr Leu His Phe Leu Ser Val Val Thr Glu Asp Gly Pro 
    210                 215                 220                 


Glu Pro Lys Asp Lys Gly Ser Leu Pro Gln Pro Pro Ile Thr Glu Val 
225                 230                 235                 240 


Glu Ser Gln Val Phe Ser Glu Lys Leu Ala Thr Asp Thr Ser Thr Phe 
                245                 250                 255     


Glu Ala Thr Ser Glu Gly Thr Leu Glu Leu Gln Gln Arg Asn Pro Lys 
            260                 265                 270         


Ala Glu Arg Leu Arg Trp Ser Pro Ala Gln Glu Glu Ser Phe Arg Gln 
        275                 280                 285             


Met Val Val Ile His Lys Glu Ile Pro Thr Gly Lys Lys Asp His Glu 
    290                 295                 300                 


Cys Ser Glu Cys Gly Lys Thr Phe Ile Tyr Asn Ser His Leu Val Val 
305                 310                 315                 320 


His Gln Arg Val His Ser Gly Glu Lys Pro Tyr Lys Cys Ser Asp Cys 
                325                 330                 335     


Gly Lys Thr Phe Lys Gln Ser Ser Asn Leu Gly Gln His Gln Arg Ile 
            340                 345                 350         


His Thr Gly Glu Lys Pro Phe Glu Cys Asn Glu Cys Gly Lys Ala Phe 
        355                 360                 365             


Arg Trp Gly Ala His Leu Val Gln His Gln Arg Ile His Ser Gly Glu 
    370                 375                 380                 


Lys Pro Tyr Glu Cys Asn Glu Cys Gly Lys Ala Phe Ser Gln Ser Ser 
385                 390                 395                 400 


Tyr Leu Ser Gln His Arg Arg Ile His Ser Gly Glu Lys Pro Phe Ile 
                405                 410                 415     


Cys Lys Glu Cys Gly Lys Ala Tyr Gly Trp Cys Ser Glu Leu Ile Arg 
            420                 425                 430         


His Arg Arg Val His Ala Arg Lys Glu Pro Ser His 
        435                 440                 


<210>  569
<211>  341
<212>  PRT
<213>  Homo sapiens

<400>  569

Met Gly Glu Pro Gly Pro Pro Ser Pro Pro Ala Pro Lys Ala Ala Pro 
1               5                   10                  15      


Gly Leu Ile Asp Ser Phe Ser Glu Met Asn Asn Tyr Arg Arg Ala Met 
            20                  25                  30          


Gln Lys Met Ala Glu Asp Ile Leu Ser Leu Arg Arg Gln Ala Ser Ile 
        35                  40                  45              


Leu Glu Gly Glu Asn Arg Ile Leu Arg Ser Arg Leu Ala Gln Gln Glu 
    50                  55                  60                  


Glu Glu Glu Gly Gln Gly Lys Ala Ser Glu Ala Gln Asn Thr Val Ser 
65                  70                  75                  80  


Met Lys Gln Lys Leu Leu Leu Ser Glu Leu Asp Met Lys Lys Leu Arg 
                85                  90                  95      


Asp Arg Val Gln His Leu Gln Asn Glu Leu Ile Arg Lys Asn Asp Arg 
            100                 105                 110         


Glu Lys Glu Leu Leu Leu Leu Tyr Gln Ala Gln Gln Pro Gln Ala Ala 
        115                 120                 125             


Leu Leu Lys Gln Tyr Gln Gly Lys Leu Gln Lys Met Lys Ala Leu Glu 
    130                 135                 140                 


Glu Thr Val Arg His Gln Glu Lys Val Ile Glu Lys Met Glu Arg Val 
145                 150                 155                 160 


Leu Glu Asp Arg Leu Gln Asp Arg Ser Lys Pro Pro Pro Leu Asn Arg 
                165                 170                 175     


Gln Gln Gly Lys Pro Tyr Thr Gly Phe Pro Met Leu Ser Ala Ser Gly 
            180                 185                 190         


Leu Pro Leu Gly Ser Met Gly Glu Asn Leu Pro Val Glu Leu Tyr Ser 
        195                 200                 205             


Val Leu Leu Ala Glu Asn Ala Lys Leu Arg Thr Glu Leu Asp Lys Asn 
    210                 215                 220                 


Arg His Gln Gln Ala His His Ser Ala Ala Thr Gly Pro Ala Gly Gly 
225                 230                 235                 240 


Pro Arg Gly Val Gly Ser Arg Arg Arg Leu Asp Arg Glu Ala Thr Arg 
                245                 250                 255     


Asp Ala Trp Pro Arg Pro Leu Arg Val His Arg Asp Pro Ala Arg Thr 
            260                 265                 270         


Gly Ser Pro Leu Trp Tyr Phe Arg Gln Val Gln Pro Pro Gly Gln Ala 
        275                 280                 285             


Gly Thr Arg Ser Glu Pro Asp Pro Val Pro Gly Lys Pro Val Arg Gly 
    290                 295                 300                 


Leu Ser Ser Thr Leu Gly Thr Arg Glu Ala Gly Ser Gly His Thr Ala 
305                 310                 315                 320 


Ala Gly Ala Arg Lys Arg Phe Gln Ala Pro Leu Glu Leu His His His 
                325                 330                 335     


Arg Thr Ala Cys Glu 
            340     


<210>  570
<211>  106
<212>  PRT
<213>  Homo sapiens

<400>  570

Met Ala Glu Ser Leu Arg Ser Pro Arg Arg Ser Leu Tyr Lys Leu Val 
1               5                   10                  15      


Gly Ser Pro Pro Trp Lys Glu Ala Phe Arg Gln Arg Cys Leu Glu Arg 
            20                  25                  30          


Met Arg Asn Ser Arg Asp Arg Leu Leu Asn Arg Tyr Arg Gln Ala Gly 
        35                  40                  45              


Ser Ser Gly Pro Gly Asn Ser Gln Asn Ser Phe Leu Val Gln Glu Val 
    50                  55                  60                  


Met Glu Glu Glu Trp Asn Ala Leu Gln Ser Val Glu Asn Cys Pro Glu 
65                  70                  75                  80  


Asp Leu Ala Gln Leu Glu Glu Leu Ile Asp Met Ala Val Leu Glu Glu 
                85                  90                  95      


Ile Gln Gln Glu Leu Ile Asn Gln Gly Leu 
            100                 105     


<210>  571
<211>  365
<212>  PRT
<213>  Homo sapiens

<400>  571

Met Asn Ile Met Asp Phe Asn Val Lys Lys Leu Ala Ala Asp Ala Gly 
1               5                   10                  15      


Thr Phe Leu Ser Arg Ala Val Gln Phe Thr Glu Glu Lys Leu Gly Gln 
            20                  25                  30          


Ala Glu Lys Thr Glu Leu Asp Ala His Leu Glu Asn Leu Leu Ser Lys 
        35                  40                  45              


Ala Glu Cys Thr Lys Ile Trp Thr Glu Lys Ile Met Lys Gln Thr Glu 
    50                  55                  60                  


Val Leu Leu Gln Pro Asn Pro Asn Ala Arg Ile Glu Glu Phe Val Tyr 
65                  70                  75                  80  


Glu Lys Leu Asp Arg Lys Ala Pro Ser Arg Ile Asn Asn Pro Glu Leu 
                85                  90                  95      


Leu Gly Gln Tyr Met Ile Asp Ala Gly Thr Glu Phe Gly Pro Gly Thr 
            100                 105                 110         


Ala Tyr Gly Asn Ala Leu Ile Lys Cys Gly Glu Thr Gln Lys Arg Ile 
        115                 120                 125             


Gly Thr Ala Asp Arg Glu Leu Ile Gln Thr Ser Ala Leu Asn Phe Leu 
    130                 135                 140                 


Thr Pro Leu Arg Asn Phe Ile Glu Gly Asp Tyr Lys Thr Ile Ala Lys 
145                 150                 155                 160 


Glu Arg Lys Leu Leu Gln Asn Lys Arg Leu Asp Leu Asp Ala Ala Lys 
                165                 170                 175     


Thr Arg Leu Lys Lys Ala Lys Ala Ala Glu Thr Arg Asn Ser Ser Glu 
            180                 185                 190         


Gln Glu Leu Arg Ile Thr Gln Ser Glu Phe Asp Arg Gln Ala Glu Ile 
        195                 200                 205             


Thr Arg Leu Leu Leu Glu Gly Ile Ser Ser Thr His Ala His His Leu 
    210                 215                 220                 


Arg Cys Leu Asn Asp Phe Val Glu Ala Gln Met Thr Tyr Tyr Ala Gln 
225                 230                 235                 240 


Cys Tyr Gln Tyr Met Leu Asp Leu Gln Lys Gln Leu Gly Ser Phe Pro 
                245                 250                 255     


Ser Asn Tyr Leu Ser Asn Asn Asn Gln Thr Ser Val Thr Pro Val Pro 
            260                 265                 270         


Ser Val Leu Pro Asn Ala Ile Gly Ser Ser Ala Met Ala Ser Thr Ser 
        275                 280                 285             


Gly Leu Val Ile Thr Ser Pro Ser Asn Leu Ser Asp Leu Lys Glu Cys 
    290                 295                 300                 


Ser Gly Ser Arg Lys Ala Arg Val Leu Tyr Asp Tyr Asp Ala Ala Asn 
305                 310                 315                 320 


Ser Thr Glu Leu Ser Leu Leu Ala Asp Glu Val Ile Thr Val Phe Ser 
                325                 330                 335     


Val Val Gly Met Asp Ser Asp Trp Leu Met Gly Glu Arg Gly Asn Gln 
            340                 345                 350         


Lys Gly Lys Val Pro Ile Thr Tyr Leu Glu Leu Leu Asn 
        355                 360                 365 


<210>  572
<211>  256
<212>  PRT
<213>  Homo sapiens

<400>  572

Met Pro Leu His Lys Tyr Pro Val Trp Leu Trp Lys Arg Leu Gln Leu 
1               5                   10                  15      


Arg Glu Gly Ile Cys Ser Arg Leu Pro Gly His Tyr Leu Arg Ser Leu 
            20                  25                  30          


Glu Glu Glu Arg Thr Pro Thr Pro Val His Tyr Arg Pro His Gly Ala 
        35                  40                  45              


Lys Phe Lys Ile Asn Pro Lys Asn Gly Gln Arg Glu Arg Val Glu Asp 
    50                  55                  60                  


Val Pro Ile Pro Ile Tyr Phe Pro Pro Glu Ser Gln Arg Gly Leu Trp 
65                  70                  75                  80  


Gly Gly Glu Gly Trp Ile Leu Gly Gln Ile Tyr Ala Asn Asn Asp Lys 
                85                  90                  95      


Leu Ser Lys Arg Leu Lys Lys Val Trp Lys Pro Gln Leu Phe Glu Arg 
            100                 105                 110         


Glu Phe Tyr Ser Glu Ile Leu Asp Lys Lys Phe Thr Val Thr Val Thr 
        115                 120                 125             


Met Arg Thr Leu Asp Leu Ile Asp Glu Ala Tyr Gly Leu Asp Phe Tyr 
    130                 135                 140                 


Ile Leu Lys Thr Pro Lys Glu Asp Leu Cys Ser Lys Phe Gly Met Asp 
145                 150                 155                 160 


Leu Lys Arg Gly Met Leu Leu Arg Leu Ala Arg Gln Asp Pro Gln Leu 
                165                 170                 175     


His Pro Glu Asp Pro Glu Arg Arg Ala Ala Ile Tyr Asp Lys Tyr Lys 
            180                 185                 190         


Glu Phe Ala Ile Pro Glu Glu Glu Ala Glu Trp Val Gly Leu Thr Leu 
        195                 200                 205             


Glu Glu Ala Ile Glu Lys Gln Arg Leu Leu Glu Glu Lys Asp Pro Val 
    210                 215                 220                 


Pro Leu Phe Lys Ile Tyr Val Ala Glu Leu Ile Gln Gln Leu Gln Gln 
225                 230                 235                 240 


Gln Ala Leu Ser Glu Pro Ala Val Val Gln Lys Arg Ala Ser Gly Gln 
                245                 250                 255     


<210>  573
<211>  184
<212>  PRT
<213>  Homo sapiens

<400>  573

Met Ala Glu Pro Gln Pro Pro Ser Gly Gly Leu Thr Asp Glu Ala Ala 
1               5                   10                  15      


Leu Ser Cys Cys Ser Asp Ala Asp Pro Ser Thr Lys Asp Phe Leu Leu 
            20                  25                  30          


Gln Gln Thr Met Leu Arg Val Lys Asp Pro Lys Lys Ser Leu Asp Phe 
        35                  40                  45              


Tyr Thr Arg Val Leu Gly Met Thr Leu Ile Gln Lys Cys Asp Phe Pro 
    50                  55                  60                  


Ile Met Lys Phe Ser Leu Tyr Phe Leu Ala Tyr Glu Asp Lys Asn Asp 
65                  70                  75                  80  


Ile Pro Lys Glu Lys Asp Glu Lys Ile Ala Trp Ala Leu Ser Arg Lys 
                85                  90                  95      


Ala Thr Leu Glu Leu Thr His Asn Trp Gly Thr Glu Asp Asp Glu Thr 
            100                 105                 110         


Gln Ser Tyr His Asn Gly Asn Ser Asp Pro Arg Gly Phe Gly His Ile 
        115                 120                 125             


Gly Ile Ala Val Pro Asp Val Tyr Ser Ala Cys Lys Arg Phe Glu Glu 
    130                 135                 140                 


Leu Gly Val Lys Phe Val Lys Lys Pro Asp Asp Gly Lys Met Lys Gly 
145                 150                 155                 160 


Leu Ala Phe Ile Gln Asp Pro Asp Gly Tyr Trp Ile Glu Ile Leu Asn 
                165                 170                 175     


Pro Asn Lys Met Ala Thr Leu Met 
            180                 


<210>  574
<211>  184
<212>  PRT
<213>  Homo sapiens

<400>  574

Met Gly Asn Gly Met Asn Lys Ile Leu Pro Gly Leu Tyr Ile Gly Asn 
1               5                   10                  15      


Phe Lys Asp Ala Arg Asp Ala Glu Gln Leu Ser Lys Asn Lys Val Thr 
            20                  25                  30          


His Ile Leu Ser Val His Asp Ser Ala Arg Pro Met Leu Glu Gly Val 
        35                  40                  45              


Lys Tyr Leu Cys Ile Pro Ala Ala Asp Ser Pro Ser Gln Asn Leu Thr 
    50                  55                  60                  


Arg His Phe Lys Glu Ser Ile Lys Phe Ile His Glu Cys Arg Leu Arg 
65                  70                  75                  80  


Gly Glu Ser Cys Leu Val His Cys Leu Ala Gly Val Ser Arg Ser Val 
                85                  90                  95      


Thr Leu Val Ile Ala Tyr Ile Met Thr Val Thr Asp Phe Gly Trp Glu 
            100                 105                 110         


Asp Ala Leu His Thr Val Arg Ala Gly Arg Ser Cys Ala Asn Pro Asn 
        115                 120                 125             


Val Gly Phe Gln Arg Gln Leu Gln Glu Phe Glu Lys His Glu Val His 
    130                 135                 140                 


Gln Tyr Arg Gln Trp Leu Lys Glu Glu Tyr Gly Glu Ser Pro Leu Gln 
145                 150                 155                 160 


Asp Ala Glu Glu Ala Lys Asn Ile Leu Ala Ala Pro Gly Ile Leu Lys 
                165                 170                 175     


Phe Trp Ala Phe Leu Arg Arg Leu 
            180                 


<210>  575
<211>  254
<212>  PRT
<213>  Homo sapiens

<400>  575

Met Pro Ala Lys Thr Pro Ile Tyr Leu Lys Ala Ala Asn Asn Lys Lys 
1               5                   10                  15      


Gly Lys Lys Phe Lys Leu Arg Asp Ile Leu Ser Pro Asp Met Ile Ser 
            20                  25                  30          


Pro Pro Leu Gly Asp Phe Arg His Thr Ile His Ile Gly Lys Glu Gly 
        35                  40                  45              


Gln His Asp Val Phe Gly Asp Ile Ser Phe Leu Gln Gly Asn Tyr Glu 
    50                  55                  60                  


Leu Leu Pro Gly Asn Gln Glu Lys Ala His Leu Gly Gln Phe Pro Gly 
65                  70                  75                  80  


His Asn Glu Phe Phe Arg Ala Asn Ser Thr Ser Asp Ser Val Phe Thr 
                85                  90                  95      


Glu Thr Pro Ser Pro Val Leu Lys Asn Ala Ile Ser Leu Pro Thr Ile 
            100                 105                 110         


Gly Gly Ser Gln Ala Leu Met Leu Pro Leu Leu Ser Pro Val Thr Phe 
        115                 120                 125             


Asn Ser Lys Gln Glu Ser Phe Gly Pro Ala Lys Leu Pro Arg Leu Ser 
    130                 135                 140                 


Cys Glu Pro Val Met Glu Glu Lys Ala Gln Glu Lys Ser Ser Leu Leu 
145                 150                 155                 160 


Glu Asn Gly Thr Val His Gln Gly Asp Thr Ser Trp Gly Ser Ser Gly 
                165                 170                 175     


Ser Ala Ser Gln Ser Ser Gln Gly Arg Asp Ser His Ser Ser Ser Leu 
            180                 185                 190         


Ser Glu Gln Tyr Pro Asp Trp Pro Ala Glu Asp Met Phe Asp His Pro 
        195                 200                 205             


Thr Pro Cys Glu Leu Ile Lys Gly Lys Thr Lys Ser Glu Glu Ser Leu 
    210                 215                 220                 


Ser Asp Leu Thr Gly Ser Leu Leu Ser Leu Gln Leu Asp Leu Gly Pro 
225                 230                 235                 240 


Ser Leu Leu Asp Glu Val Leu Asn Val Met Asp Lys Asn Lys 
                245                 250                 


<210>  576
<211>  402
<212>  PRT
<213>  Homo sapiens

<400>  576

Met Asn Ile His Met Lys Arg Lys Thr Ile Lys Asn Ile Asn Thr Phe 
1               5                   10                  15      


Glu Asn Arg Met Leu Met Leu Asp Gly Met Pro Ala Val Arg Val Lys 
            20                  25                  30          


Thr Glu Leu Leu Glu Ser Glu Gln Gly Ser Pro Asn Val His Asn Tyr 
        35                  40                  45              


Pro Asp Met Glu Ala Val Pro Leu Leu Leu Asn Asn Val Lys Gly Glu 
    50                  55                  60                  


Pro Pro Glu Asp Ser Leu Ser Val Asp His Phe Gln Thr Gln Thr Glu 
65                  70                  75                  80  


Pro Val Asp Leu Ser Ile Asn Lys Ala Arg Thr Ser Pro Thr Ala Val 
                85                  90                  95      


Ser Ser Ser Pro Val Ser Met Thr Ala Ser Ala Ser Ser Pro Ser Ser 
            100                 105                 110         


Thr Ser Thr Ser Ser Ser Ser Ser Ser Arg Leu Ala Ser Ser Pro Thr 
        115                 120                 125             


Val Ile Thr Ser Val Ser Ser Ala Ser Ser Ser Ser Thr Val Leu Thr 
    130                 135                 140                 


Pro Gly Pro Leu Val Ala Ser Ala Ser Gly Val Gly Gly Gln Gln Phe 
145                 150                 155                 160 


Leu His Ile Ile His Pro Val Pro Pro Ser Ser Pro Met Asn Leu Gln 
                165                 170                 175     


Ser Asn Lys Leu Ser His Val His Arg Ile Pro Val Val Val Gln Ser 
            180                 185                 190         


Val Pro Val Val Tyr Thr Ala Val Arg Ser Pro Gly Asn Val Asn Asn 
        195                 200                 205             


Thr Ile Val Val Pro Leu Leu Glu Asp Gly Arg Gly His Gly Lys Ala 
    210                 215                 220                 


Gln Met Asp Pro Arg Gly Leu Ser Pro Arg Gln Ser Lys Ser Asp Ser 
225                 230                 235                 240 


Asp Asp Asp Asp Leu Pro Asn Val Thr Leu Asp Ser Val Asn Glu Thr 
                245                 250                 255     


Gly Ser Thr Ala Leu Ser Ile Ala Arg Ala Val Gln Glu Val His Pro 
            260                 265                 270         


Ser Pro Val Ser Arg Val Arg Gly Asn Arg Met Asn Asn Gln Lys Phe 
        275                 280                 285             


Pro Cys Ser Ile Ser Pro Phe Ser Ile Glu Ser Thr Arg Arg Gln Arg 
    290                 295                 300                 


Arg Ser Glu Ser Pro Asp Ser Arg Lys Arg Arg Ile His Arg Cys Asp 
305                 310                 315                 320 


Phe Glu Gly Cys Asn Lys Val Tyr Thr Lys Ser Ser His Leu Lys Ala 
                325                 330                 335     


His Arg Arg Thr His Thr Gly Glu Lys Pro Tyr Lys Cys Thr Trp Glu 
            340                 345                 350         


Gly Cys Thr Trp Lys Phe Ala Arg Ser Asp Glu Leu Thr Arg His Tyr 
        355                 360                 365             


Arg Lys His Thr Gly Val Lys Pro Phe Lys Cys Ala Asp Cys Asp Arg 
    370                 375                 380                 


Ser Phe Ser Arg Ser Asp His Leu Ala Leu His Arg Arg Arg His Met 
385                 390                 395                 400 


Leu Val 
        


<210>  577
<211>  98
<212>  PRT
<213>  Homo sapiens

<400>  577

Met Ala Leu Leu Leu Ala Leu Ser Leu Leu Val Leu Trp Thr Ser Pro 
1               5                   10                  15      


Ala Pro Thr Leu Ser Gly Thr Asn Asp Ala Glu Asp Cys Cys Leu Ser 
            20                  25                  30          


Val Thr Gln Lys Pro Ile Pro Gly Tyr Ile Val Arg Asn Phe His Tyr 
        35                  40                  45              


Leu Leu Ile Lys Asp Gly Cys Arg Val Pro Ala Val Val Phe Thr Thr 
    50                  55                  60                  


Leu Arg Gly Arg Gln Leu Cys Ala Pro Pro Asp Gln Pro Trp Val Glu 
65                  70                  75                  80  


Arg Ile Ile Gln Arg Leu Gln Arg Thr Ser Ala Lys Met Lys Arg Arg 
                85                  90                  95      


Ser Ser 
        


<210>  578
<211>  101
<212>  PRT
<213>  Homo sapiens

<400>  578

Met Glu Arg Pro Asp Lys Ala Ala Leu Asn Ala Leu Gln Pro Pro Glu 
1               5                   10                  15      


Phe Arg Asn Glu Ser Ser Leu Ala Ser Thr Leu Lys Thr Leu Leu Phe 
            20                  25                  30          


Phe Thr Ala Leu Met Ile Thr Val Pro Ile Gly Leu Tyr Phe Thr Thr 
        35                  40                  45              


Lys Ser Tyr Ile Phe Glu Gly Ala Leu Gly Met Ser Asn Arg Asp Ser 
    50                  55                  60                  


Tyr Phe Tyr Ala Ala Ile Val Ala Val Val Ala Val His Val Val Leu 
65                  70                  75                  80  


Ala Leu Phe Val Tyr Val Ala Trp Asn Glu Gly Ser Arg Gln Trp Arg 
                85                  90                  95      


Glu Gly Lys Gln Asp 
            100     


<210>  579
<211>  170
<212>  PRT
<213>  Homo sapiens

<400>  579

Met Thr Glu Tyr Lys Leu Val Val Val Gly Ala Gly Gly Val Gly Lys 
1               5                   10                  15      


Ser Ala Leu Thr Ile Gln Leu Ile Gln Asn His Phe Val Asp Glu Tyr 
            20                  25                  30          


Asp Pro Thr Ile Glu Asp Ser Tyr Arg Lys Gln Val Val Ile Asp Gly 
        35                  40                  45              


Glu Thr Cys Leu Leu Asp Ile Leu Asp Thr Ala Gly Gln Glu Glu Tyr 
    50                  55                  60                  


Ser Ala Met Arg Asp Gln Tyr Met Arg Thr Gly Glu Gly Phe Leu Cys 
65                  70                  75                  80  


Val Phe Ala Ile Asn Asn Thr Lys Ser Phe Glu Asp Ile His Gln Tyr 
                85                  90                  95      


Arg Glu Gln Ile Lys Arg Val Lys Asp Ser Asp Asp Val Pro Met Val 
            100                 105                 110         


Leu Val Gly Asn Lys Cys Asp Leu Ala Ala Arg Thr Val Glu Ser Arg 
        115                 120                 125             


Gln Ala Gln Asp Leu Ala Arg Ser Tyr Gly Ile Pro Tyr Ile Glu Thr 
    130                 135                 140                 


Ser Ala Lys Thr Arg Gln Gly Ser Arg Ser Gly Ser Ser Ser Ser Ser 
145                 150                 155                 160 


Gly Thr Leu Trp Asp Pro Pro Gly Pro Met 
                165                 170 


<210>  580
<211>  118
<212>  PRT
<213>  Homo sapiens

<400>  580

Met Ala Ser Gln Ser Gln Gly Ile Gln Gln Leu Leu Gln Ala Glu Lys 
1               5                   10                  15      


Arg Ala Ala Glu Lys Val Ser Glu Ala Arg Lys Arg Lys Asn Arg Arg 
            20                  25                  30          


Leu Lys Gln Ala Lys Glu Glu Ala Gln Ala Glu Ile Glu Gln Tyr Arg 
        35                  40                  45              


Leu Gln Arg Glu Lys Glu Phe Lys Ala Lys Glu Ala Ala Ala Leu Gly 
    50                  55                  60                  


Ser Arg Gly Ser Cys Ser Thr Glu Val Glu Lys Glu Thr Gln Glu Lys 
65                  70                  75                  80  


Met Thr Ile Leu Gln Thr Tyr Phe Arg Gln Asn Arg Asp Glu Val Leu 
                85                  90                  95      


Asp Asn Leu Leu Ala Phe Val Cys Asp Ile Arg Pro Glu Ile His Glu 
            100                 105                 110         


Asn Tyr Arg Ile Asn Gly 
        115             


<210>  581
<211>  1152
<212>  PRT
<213>  Homo sapiens

<400>  581

Met Leu Glu Ile Cys Leu Lys Leu Val Gly Cys Lys Ser Lys Lys Gly 
1               5                   10                  15      


Leu Ser Ser Ser Ser Ser Cys Tyr Leu Glu Glu Ala Leu Gln Arg Pro 
            20                  25                  30          


Val Ala Ser Asp Phe Glu Pro Gln Gly Leu Ser Glu Ala Ala Arg Trp 
        35                  40                  45              


Asn Ser Lys Glu Asn Leu Leu Ala Gly Pro Ser Glu Asn Asp Pro Asn 
    50                  55                  60                  


Leu Phe Val Ala Leu Tyr Asp Phe Val Ala Ser Gly Asp Asn Thr Leu 
65                  70                  75                  80  


Ser Ile Thr Lys Gly Glu Lys Leu Arg Val Leu Gly Tyr Asn His Asn 
                85                  90                  95      


Gly Glu Trp Cys Glu Ala Gln Thr Lys Asn Gly Gln Gly Trp Val Pro 
            100                 105                 110         


Ser Asn Tyr Ile Thr Pro Val Asn Ser Leu Glu Lys His Ser Trp Tyr 
        115                 120                 125             


His Gly Pro Val Ser Arg Asn Ala Ala Glu Tyr Leu Leu Ser Ser Gly 
    130                 135                 140                 


Ile Asn Gly Ser Phe Leu Val Arg Glu Ser Glu Ser Ser Pro Gly Gln 
145                 150                 155                 160 


Arg Ser Ile Ser Leu Arg Tyr Glu Gly Arg Val Tyr His Tyr Arg Ile 
                165                 170                 175     


Asn Thr Ala Ser Asp Gly Lys Leu Tyr Val Ser Ser Glu Ser Arg Phe 
            180                 185                 190         


Asn Thr Leu Ala Glu Leu Val His His His Ser Thr Val Ala Asp Gly 
        195                 200                 205             


Leu Ile Thr Thr Leu His Tyr Pro Ala Pro Lys Arg Asn Lys Pro Thr 
    210                 215                 220                 


Val Tyr Gly Val Ser Pro Asn Tyr Asp Lys Trp Glu Met Glu Arg Thr 
225                 230                 235                 240 


Asp Ile Thr Met Lys His Lys Leu Gly Gly Gly Gln Tyr Gly Lys Val 
                245                 250                 255     


Tyr Glu Gly Val Trp Lys Lys Tyr Ser Leu Thr Val Ala Val Lys Thr 
            260                 265                 270         


Leu Lys Glu Asp Thr Met Glu Val Glu Glu Phe Leu Lys Glu Ala Ala 
        275                 280                 285             


Val Met Lys Glu Ile Lys His Pro Asn Leu Val Gln Leu Leu Gly Val 
    290                 295                 300                 


Cys Thr Arg Glu Pro Pro Phe Tyr Ile Ile Thr Glu Phe Met Thr Tyr 
305                 310                 315                 320 


Gly Asn Leu Leu Asp Tyr Leu Arg Glu Cys Asn Arg Gln Glu Val Asn 
                325                 330                 335     


Ala Val Val Leu Leu Tyr Met Ala Thr Gln Ile Ser Ser Ala Met Glu 
            340                 345                 350         


Tyr Leu Glu Lys Lys Asn Phe Ile His Arg Asp Leu Ala Ala Arg Asn 
        355                 360                 365             


Cys Leu Val Gly Glu Asn His Leu Val Lys Val Ala Asp Phe Gly Leu 
    370                 375                 380                 


Ser Arg Leu Met Thr Gly Asp Thr Tyr Thr Ala His Ala Gly Ala Lys 
385                 390                 395                 400 


Phe Pro Ile Lys Trp Thr Ala Pro Glu Ser Leu Ala Tyr Asn Lys Phe 
                405                 410                 415     


Ser Ile Lys Ser Asp Val Trp Ala Phe Gly Val Leu Leu Trp Glu Ile 
            420                 425                 430         


Ala Thr Tyr Gly Met Ser Pro Tyr Pro Gly Ile Asp Leu Ser Gln Val 
        435                 440                 445             


Tyr Glu Leu Leu Glu Lys Asp Tyr Arg Met Glu Arg Pro Glu Gly Cys 
    450                 455                 460                 


Pro Glu Lys Val Tyr Glu Leu Met Arg Ala Cys Trp Gln Trp Asn Pro 
465                 470                 475                 480 


Ser Asp Arg Pro Ser Phe Ala Glu Ile His Gln Ala Phe Glu Thr Met 
                485                 490                 495     


Phe Gln Glu Ser Ser Ile Ser Asp Glu Val Glu Lys Glu Leu Gly Lys 
            500                 505                 510         


Gln Gly Val Arg Gly Ala Val Ser Thr Leu Leu Gln Ala Pro Glu Leu 
        515                 520                 525             


Pro Thr Lys Thr Arg Thr Ser Arg Arg Ala Ala Glu His Arg Asp Thr 
    530                 535                 540                 


Thr Asp Val Pro Glu Met Pro His Ser Lys Gly Gln Gly Glu Ser Asp 
545                 550                 555                 560 


Pro Leu Asp His Glu Pro Ala Val Ser Pro Leu Leu Pro Arg Lys Glu 
                565                 570                 575     


Arg Gly Pro Pro Glu Gly Gly Leu Asn Glu Asp Glu Arg Leu Leu Pro 
            580                 585                 590         


Lys Asp Lys Lys Thr Asn Leu Phe Ser Ala Leu Ile Lys Lys Lys Lys 
        595                 600                 605             


Lys Thr Ala Pro Thr Pro Pro Lys Arg Ser Ser Ser Phe Arg Glu Met 
    610                 615                 620                 


Asp Gly Gln Pro Glu Arg Arg Gly Ala Gly Glu Glu Glu Gly Arg Asp 
625                 630                 635                 640 


Ile Ser Asn Gly Ala Leu Ala Phe Thr Pro Leu Asp Thr Ala Asp Pro 
                645                 650                 655     


Ala Lys Ser Pro Lys Pro Ser Asn Gly Ala Gly Val Pro Asn Gly Ala 
            660                 665                 670         


Leu Arg Glu Ser Gly Gly Ser Gly Phe Arg Ser Pro His Leu Trp Lys 
        675                 680                 685             


Lys Ser Ser Thr Leu Thr Ser Ser Arg Leu Ala Thr Gly Glu Glu Glu 
    690                 695                 700                 


Gly Gly Gly Ser Ser Ser Lys Arg Phe Leu Arg Ser Cys Ser Ala Ser 
705                 710                 715                 720 


Cys Val Pro His Gly Ala Lys Asp Thr Glu Trp Arg Ser Val Thr Leu 
                725                 730                 735     


Pro Arg Asp Leu Gln Ser Thr Gly Arg Gln Phe Asp Ser Ser Thr Phe 
            740                 745                 750         


Gly Gly His Lys Ser Glu Lys Pro Ala Leu Pro Arg Lys Arg Ala Gly 
        755                 760                 765             


Glu Asn Arg Ser Asp Gln Val Thr Arg Gly Thr Val Thr Pro Pro Pro 
    770                 775                 780                 


Arg Leu Val Lys Lys Asn Glu Glu Ala Ala Asp Glu Val Phe Lys Asp 
785                 790                 795                 800 


Ile Met Glu Ser Ser Pro Gly Ser Ser Pro Pro Asn Leu Thr Pro Lys 
                805                 810                 815     


Pro Leu Arg Arg Gln Val Thr Val Ala Pro Ala Ser Gly Leu Pro His 
            820                 825                 830         


Lys Glu Glu Ala Gly Lys Gly Ser Ala Leu Gly Thr Pro Ala Ala Ala 
        835                 840                 845             


Glu Pro Val Thr Pro Thr Ser Lys Ala Gly Ser Gly Ala Pro Gly Gly 
    850                 855                 860                 


Thr Ser Lys Gly Pro Ala Glu Glu Ser Arg Val Arg Arg His Lys His 
865                 870                 875                 880 


Ser Ser Glu Ser Pro Gly Arg Asp Lys Gly Lys Leu Ser Arg Leu Lys 
                885                 890                 895     


Pro Ala Pro Pro Pro Pro Pro Ala Ala Ser Ala Gly Lys Ala Gly Gly 
            900                 905                 910         


Lys Pro Ser Gln Ser Pro Ser Gln Glu Ala Ala Gly Glu Ala Val Leu 
        915                 920                 925             


Gly Ala Lys Thr Lys Ala Thr Ser Leu Val Asp Ala Val Asn Ser Asp 
    930                 935                 940                 


Ala Ala Lys Pro Ser Gln Pro Gly Glu Gly Leu Lys Lys Pro Val Leu 
945                 950                 955                 960 


Pro Ala Thr Pro Lys Pro Gln Ser Ala Lys Pro Ser Gly Thr Pro Ile 
                965                 970                 975     


Ser Pro Ala Pro Val Pro Ser Thr Leu Pro Ser Ala Ser Ser Ala Leu 
            980                 985                 990         


Ala Gly Asp Gln Pro Ser Ser Thr  Ala Phe Ile Pro Leu  Ile Ser Thr 
        995                 1000                 1005             


Arg Val  Ser Leu Arg Lys Thr  Arg Gln Pro Pro Glu  Arg Ile Ala 
    1010                 1015                 1020             


Ser Gly  Ala Ile Thr Lys Gly  Val Val Leu Asp Ser  Thr Glu Ala 
    1025                 1030                 1035             


Leu Cys  Leu Ala Ile Ser Arg  Asn Ser Glu Gln Met  Ala Ser His 
    1040                 1045                 1050             


Ser Ala  Val Leu Glu Ala Gly  Lys Asn Leu Tyr Thr  Phe Cys Val 
    1055                 1060                 1065             


Ser Tyr  Val Asp Ser Ile Gln  Gln Met Arg Asn Lys  Phe Ala Phe 
    1070                 1075                 1080             


Arg Glu  Ala Ile Asn Lys Leu  Glu Asn Asn Leu Arg  Glu Leu Gln 
    1085                 1090                 1095             


Ile Cys  Pro Ala Thr Ala Gly  Ser Gly Pro Ala Ala  Thr Gln Asp 
    1100                 1105                 1110             


Phe Ser  Lys Leu Leu Ser Ser  Val Lys Glu Ile Ser  Asp Ile Val 
    1115                 1120                 1125             


Gln Arg  Leu Glu Ala Cys Gln  Leu Gly Thr Asp Asp  Tyr Asp Ile 
    1130                 1135                 1140             


Pro Thr  Thr His His His His  His His 
    1145                 1150         


<210>  582
<211>  434
<212>  PRT
<213>  Homo sapiens

<400>  582

Met Arg Lys Thr Ala Leu Ala Glu Asp Gln Leu Arg Gln Gln Ser Gln 
1               5                   10                  15      


Val Glu Glu Gln Arg Val Ala Ala Leu Glu Asn Gln Ile Ser Glu Val 
            20                  25                  30          


Ser Glu Leu Leu Gly Thr Tyr Glu Lys Ala Lys Gln Lys Asp Gln Leu 
        35                  40                  45              


Ala Ile Gln Lys Leu Lys Glu Arg Ile Leu Gln Leu Asp Leu Glu Asn 
    50                  55                  60                  


Lys Thr Leu Ala Leu Ala Ala Ser Ser Arg Ser Pro Leu Asp Ser His 
65                  70                  75                  80  


Gly Glu Glu Ser Ser Leu Asp Val Asn Val Leu Lys Asp Lys Met Glu 
                85                  90                  95      


Lys Leu Lys Arg Leu Leu Gln Val Ala Ala Arg Lys Ser Gln Val Thr 
            100                 105                 110         


Leu Asp Val Glu Lys Leu Cys Asp Leu Glu Ile Met Pro Ser Ser Glu 
        115                 120                 125             


Ala Ala Asp Gly Glu Lys Ala Thr Ala Leu Tyr Tyr Gln Gln Glu Leu 
    130                 135                 140                 


Lys Gln Leu Lys Glu Glu Phe Glu Arg Tyr Lys Met Arg Ala Gln Val 
145                 150                 155                 160 


Val Leu Lys Ser Lys Asn Thr Lys Asp Gly Asn Leu Gly Lys Glu Leu 
                165                 170                 175     


Glu Ala Ala Gln Glu Gln Leu Ala Glu Leu Lys Glu Lys Tyr Ile Ser 
            180                 185                 190         


Leu Arg Leu Ser Cys Glu Glu Leu Glu His Gln His Gln Gln Glu Ala 
        195                 200                 205             


Asp Asp Trp Lys Gln Glu Leu Ala Arg Leu Gln Gln Leu His Arg Gln 
    210                 215                 220                 


Glu Leu Glu Arg Cys Gln Leu Asp Phe Arg Asp Arg Thr Leu Lys Leu 
225                 230                 235                 240 


Glu Glu Glu Leu His Lys Gln Arg Asp Arg Ala Leu Ala Val Leu Thr 
                245                 250                 255     


Glu Lys Asp Leu Glu Leu Glu Gln Leu Arg Ser Val Ala Leu Ala Ser 
            260                 265                 270         


Gly Leu Pro Gly Arg Arg Ser Pro Val Gly Gly Gly Gly Pro Gly Asp 
        275                 280                 285             


Pro Ala Asp Thr Ser Ser Ser Asp Ser Leu Thr Gln Ala Leu Gln Leu 
    290                 295                 300                 


Ala Ala Ala Asn Glu Pro Thr Phe Phe Leu Tyr Ala Glu Gln Leu Ala 
305                 310                 315                 320 


Arg Lys Glu Val Glu Ile Thr Ser Leu Arg Lys Gln Lys His Arg Leu 
                325                 330                 335     


Glu Val Glu Val His Gln Leu Gln Asp Arg Leu Leu Glu Glu Gly Glu 
            340                 345                 350         


Arg His Arg Glu Glu Val Ala Ala Leu Gln Ser His Ile Glu Lys Asn 
        355                 360                 365             


Ile Arg Asp Gln Ser Arg Glu Gly Ala Asn Leu Glu Tyr Leu Lys Asn 
    370                 375                 380                 


Ile Ile Tyr Arg Phe Leu Thr Leu Pro Asp Ser Leu Gly Arg Gln Gln 
385                 390                 395                 400 


Thr Leu Thr Ala Ile Leu Thr Ile Leu His Phe Ser Pro Glu Glu Lys 
                405                 410                 415     


Gln Val Ile Met Arg Leu Pro Thr Ser Ala Ser Trp Trp Pro Ser Gly 
            420                 425                 430         


Lys Arg 
        


<210>  583
<211>  257
<212>  PRT
<213>  Homo sapiens

<400>  583

Met Thr Ala Phe Pro Ala Ser Gly Lys Lys Arg Glu Thr Asp Tyr Ser 
1               5                   10                  15      


Asp Gly Asp Pro Leu Asp Val His Lys Arg Leu Pro Ser Ser Ala Gly 
            20                  25                  30          


Glu Asp Arg Ala Val Met Leu Gly Phe Ala Met Met Gly Phe Ser Val 
        35                  40                  45              


Leu Met Phe Phe Leu Leu Gly Thr Thr Ile Leu Lys Pro Phe Met Leu 
    50                  55                  60                  


Ser Ile Gln Arg Glu Glu Ser Thr Cys Thr Ala Ile His Thr Asp Ile 
65                  70                  75                  80  


Met Asp Asp Trp Leu Asp Cys Ala Phe Thr Cys Gly Val His Cys His 
                85                  90                  95      


Gly Gln Gly Lys Tyr Pro Cys Leu Gln Val Phe Val Asn Leu Ser His 
            100                 105                 110         


Pro Gly Gln Lys Ala Leu Leu His Tyr Asn Glu Glu Ala Val Gln Ile 
        115                 120                 125             


Asn Pro Lys Cys Phe Tyr Thr Pro Lys Cys His Gln Asp Arg Asn Asp 
    130                 135                 140                 


Leu Leu Asn Ser Ala Leu Asp Ile Lys Glu Phe Phe Asp His Lys Asn 
145                 150                 155                 160 


Gly Thr Pro Phe Ser Cys Phe Tyr Ser Pro Ala Ser Gln Ser Glu Asp 
                165                 170                 175     


Val Ile Leu Ile Lys Lys Tyr Asp Gln Met Ala Ile Phe His Cys Leu 
            180                 185                 190         


Phe Trp Pro Ser Leu Thr Leu Leu Gly Gly Ala Leu Ile Val Gly Met 
        195                 200                 205             


Val Arg Leu Thr Gln His Leu Ser Leu Leu Cys Glu Lys Tyr Ser Thr 
    210                 215                 220                 


Val Val Arg Asp Glu Val Gly Gly Lys Val Pro Tyr Ile Glu Gln His 
225                 230                 235                 240 


Gln Phe Lys Leu Cys Ile Met Arg Arg Ser Lys Gly Arg Ala Glu Lys 
                245                 250                 255     


Ser 
    


<210>  584
<211>  405
<212>  PRT
<213>  Homo sapiens

<400>  584

Met Glu Arg Leu Gln Lys Gln Pro Leu Thr Ser Pro Gly Ser Val Ser 
1               5                   10                  15      


Pro Ser Arg Asp Ser Ser Val Pro Gly Ser Pro Ser Ser Ile Val Ala 
            20                  25                  30          


Lys Met Asp Asn Gln Val Leu Gly Tyr Lys Asp Leu Ala Ala Ile Pro 
        35                  40                  45              


Lys Asp Lys Ala Ile Leu Asp Ile Glu Arg Pro Asp Leu Met Ile Tyr 
    50                  55                  60                  


Glu Pro His Phe Thr Tyr Ser Leu Leu Glu His Val Glu Leu Pro Arg 
65                  70                  75                  80  


Ser Arg Glu Arg Ser Leu Ser Pro Lys Ser Thr Ser Pro Pro Pro Ser 
                85                  90                  95      


Pro Glu Val Trp Ala Asp Ser Arg Ser Pro Gly Ile Ile Ser Gln Ala 
            100                 105                 110         


Ser Ala Pro Arg Thr Thr Gly Thr Pro Arg Thr Ser Leu Pro His Phe 
        115                 120                 125             


His His Pro Glu Thr Ser Arg Pro Asp Ser Asn Ile Tyr Lys Lys Pro 
    130                 135                 140                 


Pro Ile Tyr Lys Gln Arg Glu Ser Val Gly Gly Ser Pro Gln Thr Lys 
145                 150                 155                 160 


His Leu Ile Glu Asp Leu Ile Ile Glu Ser Ser Lys Phe Pro Ala Ala 
                165                 170                 175     


Gln Pro Pro Asp Pro Asn Gln Pro Ala Lys Ile Glu Thr Asp Tyr Trp 
            180                 185                 190         


Pro Cys Pro Pro Ser Leu Ala Val Val Glu Thr Glu Trp Arg Lys Arg 
        195                 200                 205             


Lys Ala Ser Arg Arg Gly Ala Glu Glu Glu Glu Glu Glu Glu Asp Asp 
    210                 215                 220                 


Asp Ser Gly Glu Glu Met Lys Ala Leu Arg Glu Arg Gln Arg Glu Glu 
225                 230                 235                 240 


Leu Ser Lys Val Thr Ser Asn Leu Gly Lys Met Ile Leu Lys Glu Glu 
                245                 250                 255     


Met Glu Lys Ser Leu Pro Ile Arg Arg Lys Thr Arg Ser Leu Pro Asp 
            260                 265                 270         


Arg Thr Pro Phe His Thr Ser Leu His Gln Gly Thr Ser Lys Ser Ser 
        275                 280                 285             


Ser Leu Pro Ala Tyr Gly Arg Thr Thr Leu Ser Arg Leu Gln Ser Thr 
    290                 295                 300                 


Glu Phe Ser Pro Ser Gly Ser Glu Thr Gly Ser Pro Gly Leu Gln Asn 
305                 310                 315                 320 


Gly Glu Gly Gln Arg Gly Arg Met Asp Arg Gly Asn Ser Leu Pro Cys 
                325                 330                 335     


Val Leu Glu Gln Lys Ile Tyr Pro Tyr Glu Met Leu Val Val Thr Asn 
            340                 345                 350         


Lys Gly Arg Thr Lys Leu Pro Pro Gly Val Asp Arg Met Arg Leu Glu 
        355                 360                 365             


Arg His Leu Ser Ala Glu Asp Phe Ser Arg Val Phe Ala Met Ser Pro 
    370                 375                 380                 


Glu Glu Phe Gly Lys Leu Ala Leu Trp Lys Arg Asn Glu Leu Lys Lys 
385                 390                 395                 400 


Lys Ala Ser Leu Phe 
                405 


<210>  585
<211>  323
<212>  PRT
<213>  Homo sapiens

<400>  585

Met Ala Ala Ala Ala Leu Pro Ala Trp Leu Ser Leu Gln Ser Arg Ala 
1               5                   10                  15      


Arg Thr Leu Arg Ala Phe Ser Thr Ala Val Tyr Ser Ala Thr Pro Val 
            20                  25                  30          


Pro Thr Pro Ser Leu Pro Glu Arg Thr Pro Gly Asn Glu Arg Pro Pro 
        35                  40                  45              


Arg Arg Lys Ala Leu Pro Pro Arg Thr Glu Lys Met Ala Val Asp Gln 
    50                  55                  60                  


Asp Trp Pro Ser Val Tyr Pro Val Ala Ala Pro Phe Lys Pro Ser Ala 
65                  70                  75                  80  


Val Pro Leu Pro Val Arg Met Gly Tyr Pro Val Lys Lys Gly Val Pro 
                85                  90                  95      


Met Ala Lys Glu Gly Asn Leu Glu Leu Leu Lys Ile Pro Asn Phe Leu 
            100                 105                 110         


His Leu Thr Pro Val Ala Ile Lys Lys His Cys Glu Ala Leu Lys Asp 
        115                 120                 125             


Phe Cys Thr Glu Trp Pro Ala Ala Leu Asp Ser Asp Glu Lys Cys Glu 
    130                 135                 140                 


Lys His Phe Pro Ile Glu Ile Asp Ser Thr Asp Tyr Val Ser Ser Gly 
145                 150                 155                 160 


Pro Ser Val Arg Asn Pro Arg Ala Arg Val Val Val Leu Arg Val Lys 
                165                 170                 175     


Leu Ser Ser Leu Asn Leu Asp Asp His Ala Lys Lys Lys Leu Ile Lys 
            180                 185                 190         


Leu Val Gly Glu Arg Tyr Cys Lys Thr Thr Asp Val Leu Thr Ile Lys 
        195                 200                 205             


Thr Asp Arg Cys Pro Leu Arg Arg Gln Asn Tyr Asp Tyr Ala Val Tyr 
    210                 215                 220                 


Leu Leu Thr Val Leu Tyr His Glu Ser Trp Asn Thr Glu Glu Trp Glu 
225                 230                 235                 240 


Lys Ser Lys Thr Glu Ala Asp Met Glu Glu Tyr Ile Trp Glu Asn Ser 
                245                 250                 255     


Ser Ser Glu Arg Asn Ile Leu Glu Thr Leu Leu Gln Met Lys Ala Ala 
            260                 265                 270         


Glu Lys Asn Met Glu Ile Asn Lys Glu Glu Leu Leu Gly Thr Lys Glu 
        275                 280                 285             


Ile Glu Glu Tyr Lys Lys Ser Val Val Ser Leu Lys Asn Glu Glu Glu 
    290                 295                 300                 


Asn Glu Asn Ser Ile Ser Gln Tyr Lys Glu Ser Val Lys Arg Leu Leu 
305                 310                 315                 320 


Asn Val Thr 
            


<210>  586
<211>  146
<212>  PRT
<213>  Homo sapiens

<400>  586

Met Thr Leu Thr Lys Gly Ser Phe Thr Tyr Ser Ser Gly Glu Glu Tyr 
1               5                   10                  15      


Arg Gly Glu Trp Lys Glu Gly Arg Arg His Gly Phe Gly Gln Leu Met 
            20                  25                  30          


Phe Ala Asp Gly Gly Thr Tyr Leu Gly His Phe Glu Asn Gly Leu Phe 
        35                  40                  45              


Asn Gly Phe Gly Val Leu Thr Phe Ser Asp Gly Ser Arg Tyr Glu Gly 
    50                  55                  60                  


Glu Phe Ala Gln Gly Lys Phe Asn Gly Val Gly Val Phe Ile Arg Tyr 
65                  70                  75                  80  


Asp Asn Met Thr Phe Glu Gly Glu Phe Lys Asn Gly Arg Val Asp Gly 
                85                  90                  95      


Phe Gly Leu Leu Thr Phe Pro Asp Gly Ser His Gly Ile Pro Arg Asn 
            100                 105                 110         


Glu Gly Leu Phe Glu Asn Asn Lys Leu Leu Arg Arg Glu Lys Cys Ser 
        115                 120                 125             


Ala Ile Val Gln Arg Ala Gln Ser Ala Ser Lys Ser Ala Arg Asn Leu 
    130                 135                 140                 


Thr Ala 
145     


<210>  587
<211>  323
<212>  PRT
<213>  Homo sapiens

<400>  587

Met Gly Leu Phe Asp Arg Gly Val Gln Met Leu Leu Thr Thr Val Gly 
1               5                   10                  15      


Ala Phe Ala Ala Phe Ser Leu Met Thr Ile Ala Val Gly Thr Asp Tyr 
            20                  25                  30          


Trp Leu Tyr Ser Arg Gly Val Cys Lys Thr Lys Ser Val Ser Glu Asn 
        35                  40                  45              


Glu Thr Ser Lys Lys Asn Glu Glu Val Met Thr His Ser Gly Leu Trp 
    50                  55                  60                  


Arg Thr Cys Cys Leu Glu Gly Asn Phe Lys Gly Leu Cys Lys Gln Ile 
65                  70                  75                  80  


Asp His Phe Pro Glu Asp Ala Asp Tyr Glu Ala Asp Thr Ala Glu Tyr 
                85                  90                  95      


Phe Leu Arg Ala Val Arg Ala Ser Ser Ile Phe Pro Ile Leu Ser Val 
            100                 105                 110         


Ile Leu Leu Phe Met Gly Gly Leu Cys Ile Ala Ala Ser Glu Phe Tyr 
        115                 120                 125             


Lys Thr Arg His Asn Ile Ile Leu Ser Ala Gly Ile Phe Phe Val Ser 
    130                 135                 140                 


Ala Gly Leu Ser Asn Ile Ile Gly Ile Ile Val Tyr Ile Ser Ala Asn 
145                 150                 155                 160 


Ala Gly Asp Pro Ser Lys Ser Asp Ser Lys Lys Asn Ser Tyr Ser Tyr 
                165                 170                 175     


Gly Trp Ser Phe Tyr Phe Gly Ala Leu Ser Phe Ile Ile Ala Glu Met 
            180                 185                 190         


Val Gly Val Leu Ala Val His Met Phe Ile Asp Arg His Lys Gln Leu 
        195                 200                 205             


Arg Ala Thr Ala Arg Ala Thr Asp Tyr Leu Gln Ala Ser Ala Ile Thr 
    210                 215                 220                 


Arg Ile Pro Ser Tyr Arg Tyr Arg Tyr Gln Arg Arg Ser Arg Ser Ser 
225                 230                 235                 240 


Ser Arg Ser Thr Glu Pro Ser His Ser Arg Asp Ala Ser Pro Val Gly 
                245                 250                 255     


Ile Lys Gly Phe Asn Thr Leu Pro Ser Thr Glu Ile Ser Met Tyr Thr 
            260                 265                 270         


Leu Ser Arg Asp Pro Leu Lys Ala Ala Thr Thr Pro Thr Ala Thr Tyr 
        275                 280                 285             


Asn Ser Asp Arg Asp Asn Ser Phe Leu Gln Val His Asn Cys Ile Gln 
    290                 295                 300                 


Lys Glu Asn Lys Asp Ser Leu His Ser Asn Thr Ala Asn Arg Arg Thr 
305                 310                 315                 320 


Thr Pro Val 
            


<210>  588
<211>  137
<212>  PRT
<213>  Homo sapiens

<400>  588

Met Ser Leu Phe Ala Ser Pro Thr Ser Ser Glu Glu Gln Lys His Arg 
1               5                   10                  15      


Asn Gly Leu Ser Asn Glu Lys Arg Lys Lys Leu Asn His Pro Ser Leu 
            20                  25                  30          


Thr Glu Ser Lys Glu Ser Thr Thr Lys Asp Asn Asp Glu Phe Met Met 
        35                  40                  45              


Leu Leu Ser Lys Val Glu Lys Leu Ser Glu Glu Ile Met Glu Ile Met 
    50                  55                  60                  


Gln Asn Leu Ser Ser Ile Gln Ala Leu Glu Gly Ser Arg Glu Leu Glu 
65                  70                  75                  80  


Asn Leu Ile Gly Ile Ser Cys Ala Ser His Phe Leu Lys Arg Glu Met 
                85                  90                  95      


Gln Lys Thr Lys Glu Leu Met Thr Lys Val Asn Lys Gln Lys Leu Phe 
            100                 105                 110         


Glu Lys Ser Thr Gly Leu Pro His Lys Ala Ser Arg His Leu Asp Ser 
        115                 120                 125             


Tyr Glu Phe Leu Lys Ala Ile Leu Asn 
    130                 135         


<210>  589
<211>  533
<212>  PRT
<213>  Homo sapiens

<400>  589

Met Gly Ser Gly Ser Ser Ser Tyr Arg Pro Lys Ala Ile Tyr Leu Asp 
1               5                   10                  15      


Ile Asp Gly Arg Ile Gln Lys Val Ile Phe Ser Lys Tyr Cys Asn Ser 
            20                  25                  30          


Ser Asp Ile Met Asp Leu Phe Cys Ile Ala Thr Gly Leu Pro Arg Asn 
        35                  40                  45              


Thr Thr Ile Ser Leu Leu Thr Thr Asp Asp Ala Met Val Ser Ile Asp 
    50                  55                  60                  


Pro Thr Met Pro Ala Asn Ser Glu Arg Thr Pro Tyr Lys Val Arg Pro 
65                  70                  75                  80  


Val Ala Ile Lys Gln Leu Ser Glu Arg Glu Glu Leu Ile Gln Ser Val 
                85                  90                  95      


Leu Ala Gln Val Ala Glu Gln Phe Ser Arg Ala Phe Lys Ile Asn Glu 
            100                 105                 110         


Leu Lys Ala Glu Val Ala Asn His Leu Ala Val Leu Glu Lys Arg Val 
        115                 120                 125             


Glu Leu Glu Gly Leu Lys Val Val Glu Ile Glu Lys Cys Lys Ser Asp 
    130                 135                 140                 


Ile Lys Lys Met Arg Glu Glu Leu Ala Ala Arg Ser Ser Arg Thr Asn 
145                 150                 155                 160 


Cys Pro Cys Lys Tyr Ser Phe Leu Asp Asn His Lys Lys Leu Thr Pro 
                165                 170                 175     


Arg Arg Asp Val Pro Thr Tyr Pro Lys Tyr Leu Leu Ser Pro Glu Thr 
            180                 185                 190         


Ile Glu Ala Leu Arg Lys Pro Thr Phe Asp Val Trp Leu Trp Glu Pro 
        195                 200                 205             


Asn Glu Met Leu Ser Cys Leu Glu His Met Tyr His Asp Leu Gly Leu 
    210                 215                 220                 


Val Arg Asp Phe Ser Ile Asn Pro Val Thr Leu Arg Arg Trp Leu Phe 
225                 230                 235                 240 


Cys Val His Asp Asn Tyr Arg Asn Asn Pro Phe His Asn Phe Arg His 
                245                 250                 255     


Cys Phe Cys Val Ala Gln Met Met Tyr Ser Met Val Trp Leu Cys Ser 
            260                 265                 270         


Leu Gln Glu Lys Phe Ser Gln Thr Asp Ile Leu Ile Leu Met Thr Ala 
        275                 280                 285             


Ala Ile Cys His Asp Leu Asp His Pro Gly Tyr Asn Asn Thr Tyr Gln 
    290                 295                 300                 


Ile Asn Ala Arg Thr Glu Leu Ala Val Arg Tyr Asn Asp Ile Ser Pro 
305                 310                 315                 320 


Leu Glu Asn His His Cys Ala Val Ala Phe Gln Ile Leu Ala Glu Pro 
                325                 330                 335     


Glu Cys Asn Ile Phe Ser Asn Ile Pro Pro Asp Gly Phe Lys Gln Ile 
            340                 345                 350         


Arg Gln Gly Met Ile Thr Leu Ile Leu Ala Thr Asp Met Ala Arg His 
        355                 360                 365             


Ala Glu Ile Met Asp Ser Phe Lys Glu Lys Met Glu Asn Phe Asp Tyr 
    370                 375                 380                 


Ser Asn Glu Glu His Met Thr Leu Leu Lys Met Ile Leu Ile Lys Cys 
385                 390                 395                 400 


Cys Asp Ile Ser Asn Glu Val Arg Pro Met Glu Val Ala Glu Pro Trp 
                405                 410                 415     


Val Asp Cys Leu Leu Glu Glu Tyr Phe Met Gln Ser Asp Arg Glu Lys 
            420                 425                 430         


Ser Glu Gly Leu Pro Val Ala Pro Phe Met Asp Arg Asp Lys Val Thr 
        435                 440                 445             


Lys Ala Thr Ala Gln Ile Gly Phe Ile Lys Phe Val Leu Ile Pro Met 
    450                 455                 460                 


Phe Glu Thr Val Thr Lys Leu Phe Pro Met Val Glu Glu Ile Met Leu 
465                 470                 475                 480 


Gln Pro Leu Trp Glu Ser Arg Asp Arg Tyr Glu Glu Leu Lys Arg Ile 
                485                 490                 495     


Asp Asp Ala Met Lys Glu Leu Gln Lys Lys Thr Asp Ser Leu Thr Ser 
            500                 505                 510         


Gly Ala Thr Glu Lys Ser Arg Glu Arg Ser Arg Asp Val Lys Asn Ser 
        515                 520                 525             


Glu Gly Asp Cys Ala 
    530             


<210>  590
<211>  231
<212>  PRT
<213>  Homo sapiens

<400>  590

Met Phe Leu Val Gly Leu Thr Gly Gly Ile Ala Ser Gly Lys Ser Ser 
1               5                   10                  15      


Val Ile Gln Val Phe Gln Gln Leu Gly Cys Ala Val Ile Asp Val Asp 
            20                  25                  30          


Val Met Ala Arg His Val Val Gln Pro Gly Tyr Pro Ala His Arg Arg 
        35                  40                  45              


Ile Val Glu Val Phe Gly Thr Glu Val Leu Leu Glu Asn Gly Asp Ile 
    50                  55                  60                  


Asn Arg Lys Val Leu Gly Asp Leu Ile Phe Asn Gln Pro Asp Arg Arg 
65                  70                  75                  80  


Gln Leu Leu Ile Ala Ile Thr His Pro Glu Ile Arg Lys Glu Met Met 
                85                  90                  95      


Lys Glu Thr Phe Lys Tyr Phe Leu Arg Gly Tyr Arg Tyr Val Ile Leu 
            100                 105                 110         


Asp Ile Pro Leu Leu Phe Glu Thr Lys Lys Leu Leu Lys Tyr Met Lys 
        115                 120                 125             


His Thr Val Val Val Tyr Cys Asp Arg Asp Thr Gln Leu Ala Arg Leu 
    130                 135                 140                 


Met Arg Arg Asn Ser Leu Asn Arg Lys Asp Ala Glu Ala Arg Ile Asn 
145                 150                 155                 160 


Ala Gln Leu Pro Leu Thr Asp Lys Ala Arg Met Ala Arg His Val Leu 
                165                 170                 175     


Asp Asn Ser Gly Glu Trp Ser Val Thr Lys Arg Gln Val Ile Leu Leu 
            180                 185                 190         


His Thr Glu Leu Glu Arg Ser Leu Glu Tyr Leu Pro Leu Arg Phe Gly 
        195                 200                 205             


Val Leu Thr Gly Leu Ala Ala Ile Ala Ser Leu Leu Tyr Leu Leu Thr 
    210                 215                 220                 


His Tyr Leu Leu Pro Tyr Ala 
225                 230     


<210>  591
<211>  244
<212>  PRT
<213>  Homo sapiens

<400>  591

Met Ala Ala Val Gly Phe Glu Glu Phe Ser Ala Pro Pro Gly Ser Glu 
1               5                   10                  15      


Leu Ala Leu Pro Pro Leu Phe Gly Gly His Ile Leu Glu Ser Glu Leu 
            20                  25                  30          


Glu Thr Glu Val Glu Phe Val Ser Gly Gly Leu Gly Gly Ser Gly Leu 
        35                  40                  45              


Arg Glu Arg Asp Glu Glu Glu Glu Ala Ala Arg Gly Arg Arg Arg Arg 
    50                  55                  60                  


Gln Arg Glu Leu Asn Arg Arg Lys Tyr Gln Ala Leu Gly Arg Arg Cys 
65                  70                  75                  80  


Arg Glu Ile Glu Gln Val Asn Glu Arg Val Leu Asn Arg Leu His Gln 
                85                  90                  95      


Val Gln Arg Ile Thr Arg Arg Leu Gln Gln Glu Arg Arg Phe Leu Met 
            100                 105                 110         


Arg Val Leu Asp Ser Tyr Gly Asp Asp Tyr Arg Ala Ser Gln Phe Thr 
        115                 120                 125             


Ile Val Leu Glu Asp Glu Gly Ser Gln Gly Thr Asp Ala Pro Thr Pro 
    130                 135                 140                 


Gly Asn Ala Glu Asn Glu Pro Pro Glu Lys Glu Thr Leu Ser Pro Pro 
145                 150                 155                 160 


Arg Arg Thr Pro Ala Pro Pro Glu Pro Gly Ser Pro Ala Pro Gly Glu 
                165                 170                 175     


Gly Pro Ser Gly Arg Lys Arg Arg Arg Val Pro Arg Asp Gly Arg Arg 
            180                 185                 190         


Ala Gly Asn Ala Leu Thr Pro Glu Leu Ala Pro Val Gln Ile Lys Val 
        195                 200                 205             


Glu Glu Asp Phe Gly Phe Glu Ala Asp Glu Ala Leu Asp Ser Ser Trp 
    210                 215                 220                 


Val Ser Arg Gly Pro Asp Lys Leu Leu Pro Tyr Pro Thr Leu Ala Ser 
225                 230                 235                 240 


Pro Ala Ser Asp 
                


<210>  592
<211>  616
<212>  PRT
<213>  Homo sapiens

<400>  592

Met Val Gly Gln Leu Ser Glu Gly Ala Ile Ala Ala Ile Met Gln Lys 
1               5                   10                  15      


Gly Asp Thr Asn Ile Lys Pro Ile Leu Gln Val Ile Asn Ile Arg Pro 
            20                  25                  30          


Ile Thr Thr Gly Asn Ser Pro Pro Arg Tyr Arg Leu Leu Met Ser Asp 
        35                  40                  45              


Gly Leu Asn Thr Leu Ser Ser Phe Met Leu Ala Thr Gln Leu Asn Pro 
    50                  55                  60                  


Leu Val Glu Glu Glu Gln Leu Ser Ser Asn Cys Val Cys Gln Ile His 
65                  70                  75                  80  


Arg Phe Ile Val Asn Thr Leu Lys Asp Gly Arg Arg Val Val Ile Leu 
                85                  90                  95      


Met Glu Leu Glu Val Leu Lys Ser Ala Glu Ala Val Gly Val Lys Ile 
            100                 105                 110         


Gly Asn Pro Val Pro Tyr Asn Glu Gly Leu Gly Gln Pro Gln Val Ala 
        115                 120                 125             


Pro Pro Ala Pro Ala Ala Ser Pro Ala Ala Ser Ser Arg Pro Gln Pro 
    130                 135                 140                 


Gln Asn Gly Ser Ser Gly Met Gly Ser Thr Val Ser Lys Ala Tyr Gly 
145                 150                 155                 160 


Ala Ser Lys Thr Phe Gly Lys Ala Ala Gly Pro Ser Leu Ser His Thr 
                165                 170                 175     


Ser Gly Gly Thr Gln Ser Lys Val Val Pro Ile Ala Ser Leu Thr Pro 
            180                 185                 190         


Tyr Gln Ser Lys Trp Thr Ile Cys Ala Arg Val Thr Asn Lys Ser Gln 
        195                 200                 205             


Ile Arg Thr Trp Ser Asn Ser Arg Gly Glu Gly Lys Leu Phe Ser Leu 
    210                 215                 220                 


Glu Leu Val Asp Glu Ser Gly Glu Ile Arg Ala Thr Ala Phe Asn Glu 
225                 230                 235                 240 


Gln Val Asp Lys Phe Phe Pro Leu Ile Glu Val Asn Lys Val Tyr Tyr 
                245                 250                 255     


Phe Ser Lys Gly Thr Leu Lys Ile Ala Asn Lys Gln Phe Thr Ala Val 
            260                 265                 270         


Lys Asn Asp Tyr Glu Met Thr Phe Asn Asn Glu Thr Ser Val Met Pro 
        275                 280                 285             


Cys Glu Asp Asp His His Leu Pro Thr Val Gln Phe Asp Phe Thr Gly 
    290                 295                 300                 


Ile Asp Asp Leu Glu Asn Lys Ser Lys Asp Ser Leu Val Asp Ile Ile 
305                 310                 315                 320 


Gly Ile Cys Lys Ser Tyr Glu Asp Ala Thr Lys Ile Thr Val Arg Ser 
                325                 330                 335     


Asn Asn Arg Glu Val Ala Lys Arg Asn Ile Tyr Leu Met Asp Thr Ser 
            340                 345                 350         


Gly Lys Val Val Thr Ala Thr Leu Trp Gly Glu Asp Ala Asp Lys Phe 
        355                 360                 365             


Asp Gly Ser Arg Gln Pro Val Leu Ala Ile Lys Gly Ala Arg Val Ser 
    370                 375                 380                 


Asp Phe Gly Gly Arg Ser Leu Ser Val Leu Ser Ser Ser Thr Ile Ile 
385                 390                 395                 400 


Ala Asn Pro Asp Ile Pro Glu Ala Tyr Lys Leu Arg Gly Trp Phe Asp 
                405                 410                 415     


Ala Glu Gly Gln Ala Leu Asp Gly Val Ser Ile Ser Asp Leu Lys Ser 
            420                 425                 430         


Gly Gly Val Gly Gly Ser Asn Thr Asn Trp Lys Thr Leu Tyr Glu Val 
        435                 440                 445             


Lys Ser Glu Asn Leu Gly Gln Gly Asp Lys Pro Asp Tyr Phe Ser Ser 
    450                 455                 460                 


Val Ala Thr Val Val Tyr Leu Arg Lys Glu Asn Cys Met Tyr Gln Ala 
465                 470                 475                 480 


Cys Pro Thr Gln Asp Cys Asn Lys Lys Val Ile Asp Gln Gln Asn Gly 
                485                 490                 495     


Leu Tyr Arg Cys Glu Lys Cys Asp Thr Glu Phe Pro Asn Phe Lys Tyr 
            500                 505                 510         


Arg Met Ile Leu Ser Val Asn Ile Ala Asp Phe Gln Glu Asn Gln Trp 
        515                 520                 525             


Val Thr Cys Phe Gln Glu Ser Ala Glu Ala Ile Leu Gly Gln Asn Ala 
    530                 535                 540                 


Ala Tyr Leu Gly Glu Leu Lys Asp Lys Asn Glu Gln Ala Phe Glu Glu 
545                 550                 555                 560 


Val Phe Gln Asn Ala Asn Phe Arg Ser Phe Ile Phe Arg Val Arg Val 
                565                 570                 575     


Lys Val Glu Thr Tyr Asn Asp Glu Ser Arg Ile Lys Ala Thr Val Met 
            580                 585                 590         


Asp Val Lys Pro Val Asp Tyr Arg Glu Tyr Gly Arg Arg Leu Val Met 
        595                 600                 605             


Ser Ile Arg Arg Ser Ala Leu Met 
    610                 615     


<210>  593
<211>  125
<212>  PRT
<213>  Homo sapiens

<400>  593

Met Pro His Ser Ser Asp Ser Ser Asp Ser Ser Phe Ser Arg Ser Pro 
1               5                   10                  15      


Pro Pro Gly Lys Gln Asp Ser Ser Asp Asp Val Arg Arg Val Gln Arg 
            20                  25                  30          


Arg Glu Lys Asn Arg Ile Ala Ala Gln Lys Ser Arg Gln Arg Gln Thr 
        35                  40                  45              


Gln Lys Ala Asp Thr Leu His Leu Glu Ser Glu Asp Leu Glu Lys Gln 
    50                  55                  60                  


Asn Ala Ala Leu Arg Lys Glu Ile Lys Gln Leu Thr Glu Glu Leu Lys 
65                  70                  75                  80  


Tyr Phe Thr Ser Val Leu Asn Ser His Glu Pro Leu Cys Ser Val Leu 
                85                  90                  95      


Ala Ala Ser Thr Pro Ser Pro Pro Glu Val Val Tyr Ser Ala His Ala 
            100                 105                 110         


Phe His Gln Pro His Val Ser Ser Pro Arg Phe Gln Pro 
        115                 120                 125 


<210>  594
<211>  282
<212>  PRT
<213>  Homo sapiens

<400>  594

Met Glu Gln Ser Ser Pro Gly Phe Arg Gln Thr His Leu Gln Asp Leu 
1               5                   10                  15      


Ser Glu Ala Thr Gln Asp Val Lys Glu Glu Asn His Tyr Leu Thr Pro 
            20                  25                  30          


Arg Ser Val Leu Leu Glu Leu Asp Asn Ile Ile Ala Ser Ser Asp Ser 
        35                  40                  45              


Gly Glu Ser Ile Glu Thr Asp Gly Pro Asp Gln Val Ser Gly Arg Ile 
    50                  55                  60                  


Glu Cys His Tyr Glu Pro Met Glu Ser Tyr Phe Phe Lys Glu Thr Ser 
65                  70                  75                  80  


His Glu Ser Val Asp Ser Ser Lys Glu Glu Pro Gln Thr Leu Pro Glu 
                85                  90                  95      


Thr Gln Asp Gly Asp Leu His Leu Gln Glu Gln Gly Ser Gly Ile Asp 
            100                 105                 110         


Trp Cys Leu Ser Pro Ala Asp Val Glu Ala Gln Thr Thr Asn Asp Gln 
        115                 120                 125             


Lys Gly Ser Ala Ser Leu Thr Val Val Gln Leu Ser Ile Leu Ile Asn 
    130                 135                 140                 


Asn Ile Pro Asp Glu Ser Gln Val Glu Lys Leu Asn Val Phe Leu Ser 
145                 150                 155                 160 


Pro Pro Asp Val Ile Asn Tyr Leu Ala Leu Thr Glu Ala Thr Gly Arg 
                165                 170                 175     


Ile Cys Val Ser Gln Trp Glu Gly Pro Arg Arg Leu Gly Cys Ile Phe 
            180                 185                 190         


Cys His Gly Asp His Leu Leu Ala Val Asn Asp Leu Lys Pro Gln Ser 
        195                 200                 205             


Leu Glu Glu Val Ser Leu Phe Leu Thr Arg Ser Ile Gln Lys Glu Lys 
    210                 215                 220                 


Leu Lys Leu Thr Ile Gly Arg Ile Pro Asn Ser Glu Thr Phe His Ala 
225                 230                 235                 240 


Ala Ser Cys Met Cys Pro Ser Lys Cys Gln Ser Ala Ala Pro Ser Gln 
                245                 250                 255     


Leu Asp Lys Pro Arg Leu Asn Arg Ala Pro Lys Arg Ser Pro Ala Ile 
            260                 265                 270         


Lys Lys Ser Gln Gln Lys Gly Ala Arg Glu 
        275                 280         


<210>  595
<211>  251
<212>  PRT
<213>  Homo sapiens

<400>  595

Met Glu Ser Gly Lys Met Ala Pro Pro Lys Asn Ala Pro Arg Asp Ala 
1               5                   10                  15      


Leu Val Met Ala Gln Ile Leu Lys Asp Met Gly Ile Thr Glu Tyr Glu 
            20                  25                  30          


Pro Arg Val Ile Asn Gln Met Leu Glu Phe Ala Phe Arg Tyr Val Thr 
        35                  40                  45              


Thr Ile Leu Asp Asp Ala Lys Ile Tyr Ser Ser His Ala Lys Lys Pro 
    50                  55                  60                  


Asn Val Asp Ala Asp Asp Val Arg Leu Ala Ile Gln Cys Arg Ala Asp 
65                  70                  75                  80  


Gln Ser Phe Thr Ser Pro Pro Pro Arg Asp Phe Leu Leu Asp Ile Ala 
                85                  90                  95      


Arg Gln Lys Asn Gln Thr Pro Leu Pro Leu Ile Lys Pro Tyr Ala Gly 
            100                 105                 110         


Pro Arg Leu Pro Pro Asp Arg Tyr Cys Leu Thr Ala Pro Asn Tyr Arg 
        115                 120                 125             


Leu Lys Ser Leu Ile Lys Lys Gly Pro Asn Gln Gly Arg Leu Val Pro 
    130                 135                 140                 


Arg Leu Ser Val Gly Ala Val Ser Ser Lys Pro Thr Thr Pro Thr Ile 
145                 150                 155                 160 


Ala Thr Pro Gln Thr Val Ser Val Pro Asn Lys Val Ala Thr Pro Met 
                165                 170                 175     


Ser Val Thr Ser Gln Arg Phe Thr Val Gln Ile Pro Pro Ser Gln Ser 
            180                 185                 190         


Thr Pro Val Lys Pro Val Pro Ala Thr Thr Ala Val Gln Asn Val Leu 
        195                 200                 205             


Ile Asn Pro Ser Met Ile Gly Pro Lys Asn Ile Leu Ile Thr Thr Asn 
    210                 215                 220                 


Met Val Ser Ser Gln Asn Thr Ala Asn Glu Ala Asn Pro Leu Lys Arg 
225                 230                 235                 240 


Lys His Glu Asp Asp Asp Asp Asn Asp Ile Met 
                245                 250     


<210>  596
<211>  186
<212>  PRT
<213>  Homo sapiens

<400>  596

Met Leu Ala Leu Ile Ser Arg Leu Leu Asp Trp Phe Arg Ser Leu Phe 
1               5                   10                  15      


Trp Lys Glu Glu Met Glu Leu Thr Leu Val Gly Leu Gln Tyr Ser Gly 
            20                  25                  30          


Lys Thr Thr Phe Val Asn Val Ile Ala Ser Gly Gln Phe Ser Glu Asp 
        35                  40                  45              


Met Ile Pro Thr Val Gly Phe Asn Met Arg Lys Val Thr Lys Gly Asn 
    50                  55                  60                  


Val Thr Ile Lys Ile Trp Asp Ile Gly Gly Gln Pro Arg Phe Arg Ser 
65                  70                  75                  80  


Met Trp Glu Arg Tyr Cys Arg Gly Val Asn Ala Ile Val Tyr Met Ile 
                85                  90                  95      


Asp Ala Ala Asp Arg Glu Lys Ile Glu Ala Ser Arg Asn Glu Leu His 
            100                 105                 110         


Asn Leu Leu Asp Lys Pro Gln Leu Gln Gly Ile Pro Val Leu Val Leu 
        115                 120                 125             


Gly Asn Lys Arg Asp Leu Pro Asn Ala Leu Asp Glu Lys Gln Leu Ile 
    130                 135                 140                 


Glu Lys Met Asn Leu Ser Ala Ile Gln Asp Arg Glu Ile Cys Cys Tyr 
145                 150                 155                 160 


Ser Ile Ser Cys Lys Glu Lys Asp Asn Ile Asp Ile Thr Leu Gln Trp 
                165                 170                 175     


Leu Ile Gln His Ser Lys Ser Arg Arg Ser 
            180                 185     


<210>  597
<211>  805
<212>  PRT
<213>  Homo sapiens

<400>  597

Met Glu Asp Tyr Thr Lys Ile Glu Lys Ile Gly Glu Gly Thr Tyr Gly 
1               5                   10                  15      


Val Val Tyr Lys Gly Arg His Lys Thr Thr Gly Gln Val Val Ala Met 
            20                  25                  30          


Lys Lys Ile Arg Leu Glu Ser Glu Glu Glu Gly Val Pro Ser Thr Ala 
        35                  40                  45              


Ile Arg Glu Ile Ser Leu Leu Lys Glu Leu Arg His Pro Asn Ile Val 
    50                  55                  60                  


Ser Leu Gln Asp Val Leu Met Gln Asp Ser Arg Leu Tyr Leu Ile Phe 
65                  70                  75                  80  


Glu Phe Leu Ser Met Asp Leu Lys Lys Tyr Leu Asp Ser Ile Pro Pro 
                85                  90                  95      


Gly Gln Tyr Met Asp Ser Ser Leu Val Lys Ser Tyr Leu Tyr Gln Ile 
            100                 105                 110         


Leu Gln Gly Ile Val Phe Cys His Ser Arg Arg Val Leu His Arg Asp 
        115                 120                 125             


Leu Lys Pro Gln Asn Leu Leu Ile Asp Asp Lys Gly Thr Ile Lys Leu 
    130                 135                 140                 


Ala Asp Phe Gly Leu Ala Arg Ala Phe Gly Ile Pro Ile Arg Val Tyr 
145                 150                 155                 160 


Thr His Glu Val Val Thr Leu Trp Tyr Arg Ser Pro Glu Val Leu Leu 
                165                 170                 175     


Gly Ser Ala Arg Tyr Ser Thr Pro Val Asp Ile Trp Ser Ile Gly Thr 
            180                 185                 190         


Ile Phe Ala Glu Leu Ala Thr Lys Lys Pro Leu Phe His Gly Asp Ser 
        195                 200                 205             


Glu Ile Asp Gln Leu Phe Arg Ile Phe Arg Ala Leu Gly Thr Pro Asn 
    210                 215                 220                 


Asn Glu Val Trp Pro Glu Val Glu Ser Leu Gln Asp Tyr Lys Asn Thr 
225                 230                 235                 240 


Phe Pro Lys Trp Lys Pro Gly Ser Leu Ala Ser His Val Lys Asn Leu 
                245                 250                 255     


Asp Glu Asn Gly Leu Asp Leu Leu Ser Lys Met Leu Ile Tyr Asp Pro 
            260                 265                 270         


Ala Lys Arg Ile Ser Gly Lys Met Ala Leu Asn His Pro Tyr Phe Asn 
        275                 280                 285             


Asp Leu Asp Asn Gln Ile Lys Lys Met Arg Pro Leu Ser Asn Leu Glu 
    290                 295                 300                 


Pro Ala Val Ser Arg His Ala Ser Gly Thr Asp Asp Tyr Asp Ile Pro 
305                 310                 315                 320 


Thr Thr His His His His His His Met Ser Tyr Tyr His His His His 
                325                 330                 335     


His His Asp Tyr Asp Ile Pro Thr Thr Glu Asn Leu Tyr Phe Gln Gly 
            340                 345                 350         


Ala Met Leu Val Pro Arg Gly Ser Pro Trp Gly Ser Gly Ile Gln Arg 
        355                 360                 365             


Pro Thr Ser Thr Met Ala Leu Arg Val Thr Arg Asn Ser Lys Ile Asn 
    370                 375                 380                 


Ala Glu Asn Lys Ala Lys Ile Asn Met Ala Gly Ala Lys Arg Val Pro 
385                 390                 395                 400 


Thr Ala Pro Ala Ala Thr Ser Lys Pro Gly Leu Arg Pro Arg Thr Ala 
                405                 410                 415     


Leu Gly Asp Ile Gly Asn Lys Val Ser Glu Gln Leu Gln Ala Lys Met 
            420                 425                 430         


Pro Met Lys Lys Glu Ala Lys Pro Ser Ala Thr Gly Lys Val Ile Asp 
        435                 440                 445             


Lys Lys Leu Pro Lys Pro Leu Glu Lys Val Pro Met Leu Val Pro Val 
    450                 455                 460                 


Pro Val Ser Glu Pro Val Pro Glu Pro Glu Pro Glu Pro Glu Pro Glu 
465                 470                 475                 480 


Pro Val Lys Glu Glu Lys Leu Ser Pro Glu Pro Ile Leu Val Asp Thr 
                485                 490                 495     


Ala Ser Pro Ser Pro Met Glu Thr Ser Gly Cys Ala Pro Ala Glu Glu 
            500                 505                 510         


Asp Leu Cys Gln Ala Phe Ser Asp Val Ile Leu Ala Val Asn Asp Val 
        515                 520                 525             


Asp Ala Glu Asp Gly Ala Asp Pro Asn Leu Cys Ser Glu Tyr Val Lys 
    530                 535                 540                 


Asp Ile Tyr Ala Tyr Leu Arg Gln Leu Glu Glu Glu Gln Ala Val Arg 
545                 550                 555                 560 


Pro Lys Tyr Leu Leu Gly Arg Glu Val Thr Gly Asn Met Arg Ala Ile 
                565                 570                 575     


Leu Ile Asp Trp Leu Val Gln Val Gln Met Lys Phe Arg Leu Leu Gln 
            580                 585                 590         


Glu Thr Met Tyr Met Thr Val Ser Ile Ile Asp Arg Phe Met Gln Asn 
        595                 600                 605             


Asn Cys Val Pro Lys Lys Met Leu Gln Leu Val Gly Val Thr Ala Met 
    610                 615                 620                 


Phe Ile Ala Ser Lys Tyr Glu Glu Met Tyr Pro Pro Glu Ile Gly Asp 
625                 630                 635                 640 


Phe Ala Phe Val Thr Asp Asn Thr Tyr Thr Lys His Gln Ile Arg Gln 
                645                 650                 655     


Met Glu Met Lys Ile Leu Arg Ala Leu Asn Phe Gly Leu Gly Arg Pro 
            660                 665                 670         


Leu Pro Leu His Phe Leu Arg Arg Ala Ser Lys Ile Gly Glu Val Asp 
        675                 680                 685             


Val Glu Gln His Thr Leu Ala Lys Tyr Leu Met Glu Leu Thr Met Leu 
    690                 695                 700                 


Asp Tyr Asp Met Val His Phe Pro Pro Ser Gln Ile Ala Ala Gly Ala 
705                 710                 715                 720 


Phe Cys Leu Ala Leu Lys Ile Leu Asp Asn Gly Glu Trp Thr Pro Thr 
                725                 730                 735     


Leu Gln His Tyr Leu Ser Tyr Thr Glu Glu Ser Leu Leu Pro Val Met 
            740                 745                 750         


Gln His Leu Ala Lys Asn Val Val Met Val Asn Gln Gly Leu Thr Lys 
        755                 760                 765             


His Met Thr Val Lys Asn Lys Tyr Ala Thr Ser Lys His Ala Lys Ile 
    770                 775                 780                 


Ser Thr Leu Pro Gln Leu Asn Ser Ala Leu Val Gln Asp Leu Ala Lys 
785                 790                 795                 800 


Ala Val Ala Lys Val 
                805 


<210>  598
<211>  536
<212>  PRT
<213>  Homo sapiens

<400>  598

Met Ala Gln Gly Ser His Gln Ile Asp Phe Gln Val Leu His Asp Leu 
1               5                   10                  15      


Arg Gln Lys Phe Pro Glu Val Pro Glu Val Val Val Ser Arg Cys Met 
            20                  25                  30          


Leu Gln Asn Asn Asn Asn Leu Asp Ala Cys Cys Ala Val Leu Ser Gln 
        35                  40                  45              


Glu Ser Thr Arg Tyr Leu Tyr Gly Glu Gly Asp Leu Asn Phe Ser Asp 
    50                  55                  60                  


Asp Ser Gly Ile Ser Gly Leu Arg Asn His Met Thr Ser Leu Asn Leu 
65                  70                  75                  80  


Asp Leu Gln Ser Gln Asn Ile Tyr His His Gly Arg Glu Gly Ser Arg 
                85                  90                  95      


Met Asn Gly Ser Arg Thr Leu Thr His Ser Ile Ser Asp Gly Gln Leu 
            100                 105                 110         


Gln Gly Gly Gln Ser Asn Ser Glu Leu Phe Gln Gln Glu Pro Gln Thr 
        115                 120                 125             


Ala Pro Ala Gln Val Pro Gln Gly Phe Asn Val Phe Gly Met Ser Ser 
    130                 135                 140                 


Ser Ser Gly Ala Ser Asn Ser Ala Pro His Leu Gly Phe His Leu Gly 
145                 150                 155                 160 


Ser Lys Gly Thr Ser Ser Leu Ser Gln Gln Thr Pro Arg Phe Asn Pro 
                165                 170                 175     


Ile Met Val Thr Leu Ala Pro Asn Ile Gln Thr Gly Arg Asn Thr Pro 
            180                 185                 190         


Thr Ser Leu His Ile His Gly Val Pro Pro Pro Val Leu Asn Ser Pro 
        195                 200                 205             


Gln Gly Asn Ser Ile Tyr Ile Arg Pro Tyr Ile Thr Thr Pro Gly Gly 
    210                 215                 220                 


Thr Thr Arg Gln Thr Gln Gln His Ser Gly Trp Val Ser Gln Phe Asn 
225                 230                 235                 240 


Pro Met Asn Pro Gln Gln Val Tyr Gln Pro Ser Gln Pro Gly Pro Trp 
                245                 250                 255     


Thr Thr Cys Pro Ala Ser Asn Pro Leu Ser His Thr Ser Ser Gln Gln 
            260                 265                 270         


Pro Asn Gln Gln Gly His Gln Thr Ser His Val Tyr Met Pro Ile Ser 
        275                 280                 285             


Ser Pro Thr Thr Ser Gln Pro Pro Thr Ile His Ser Ser Gly Ser Ser 
    290                 295                 300                 


Gln Ser Ser Ala His Ser Gln Tyr Asn Ile Gln Asn Ile Ser Thr Gly 
305                 310                 315                 320 


Pro Arg Lys Asn Gln Ile Glu Ile Lys Leu Glu Pro Pro Gln Arg Asn 
                325                 330                 335     


Asn Ser Ser Lys Leu Arg Ser Ser Gly Pro Arg Thr Ser Ser Thr Ser 
            340                 345                 350         


Ser Ser Val Asn Ser Gln Thr Leu Asn Arg Asn Gln Pro Thr Val Tyr 
        355                 360                 365             


Ile Ala Ala Ser Pro Pro Asn Thr Asp Glu Leu Met Ser Arg Ser Gln 
    370                 375                 380                 


Pro Lys Val Tyr Ile Ser Ala Asn Ala Ala Thr Gly Asp Glu Gln Val 
385                 390                 395                 400 


Met Arg Asn Gln Pro Thr Leu Phe Ile Ser Thr Asn Ser Gly Ala Ser 
                405                 410                 415     


Ala Ala Ser Arg Asn Met Ser Gly Gln Val Ser Met Gly Pro Ala Phe 
            420                 425                 430         


Ile His His His Pro Pro Lys Ser Arg Ala Ile Gly Asn Asn Ser Ala 
        435                 440                 445             


Thr Ser Pro Arg Val Val Val Thr Gln Pro Asn Thr Lys Tyr Thr Phe 
    450                 455                 460                 


Lys Ile Thr Val Ser Pro Asn Lys Pro Pro Ala Val Ser Pro Gly Val 
465                 470                 475                 480 


Val Ser Pro Thr Phe Glu Leu Thr Asn Leu Leu Asn His Pro Asp His 
                485                 490                 495     


Tyr Val Glu Thr Glu Asn Ile Gln His Leu Thr Asp Pro Thr Leu Ala 
            500                 505                 510         


His Val Asp Arg Ile Ser Glu Thr Arg Lys Leu Ser Met Gly Ser Asp 
        515                 520                 525             


Asp Ala Ala Tyr Thr Gln Asp Ile 
    530                 535     


<210>  599
<211>  697
<212>  PRT
<213>  Homo sapiens

<400>  599

Met Gly Glu Arg Ala Gly Ser Pro Gly Thr Asp Gln Glu Arg Glu Ala 
1               5                   10                  15      


Gly Lys His His Tyr Ser Tyr Ser Ser Asp Phe Glu Thr Pro Gln Ser 
            20                  25                  30          


Ser Gly Arg Ser Ser Leu Val Ser Ser Ser Pro Ala Ser Val Arg Arg 
        35                  40                  45              


Lys Asn Pro Lys Arg Gln Thr Ser Asp Gly Gln Val His His Gln Ala 
    50                  55                  60                  


Pro Arg Lys Pro Ser Pro Lys Gly Leu Pro Asn Arg Lys Gly Val Arg 
65                  70                  75                  80  


Val Gly Phe Arg Ser Gln Ser Leu Asn Arg Glu Pro Leu Arg Lys Asp 
                85                  90                  95      


Thr Asp Leu Val Thr Lys Arg Ile Leu Ser Ala Arg Leu Leu Lys Ile 
            100                 105                 110         


Asn Glu Leu Gln Asn Glu Val Ser Glu Leu Gln Val Lys Leu Ala Glu 
        115                 120                 125             


Leu Leu Lys Glu Asn Lys Ser Leu Lys Arg Leu Gln Tyr Arg Gln Glu 
    130                 135                 140                 


Lys Ala Leu Asn Lys Phe Glu Asp Ala Glu Asn Glu Ile Ser Gln Leu 
145                 150                 155                 160 


Ile Phe Arg His Asn Asn Glu Ile Thr Ala Leu Lys Glu Arg Leu Arg 
                165                 170                 175     


Lys Ser Gln Glu Lys Glu Arg Ala Thr Glu Lys Arg Val Lys Asp Thr 
            180                 185                 190         


Glu Ser Glu Leu Phe Arg Thr Lys Phe Ser Leu Gln Lys Leu Lys Glu 
        195                 200                 205             


Ile Ser Glu Ala Arg His Leu Pro Glu Arg Asp Asp Leu Ala Lys Lys 
    210                 215                 220                 


Leu Val Ser Ala Glu Leu Lys Leu Asp Asp Thr Glu Arg Arg Ile Lys 
225                 230                 235                 240 


Glu Leu Ser Lys Asn Leu Glu Leu Ser Thr Asn Ser Phe Gln Arg Gln 
                245                 250                 255     


Leu Leu Ala Glu Arg Lys Arg Ala Tyr Glu Ala His Asp Glu Asn Lys 
            260                 265                 270         


Val Leu Gln Lys Glu Val Gln Arg Leu Tyr His Lys Leu Lys Glu Lys 
        275                 280                 285             


Glu Arg Glu Leu Asp Ile Lys Asn Ile Tyr Ser Asn Arg Leu Pro Lys 
    290                 295                 300                 


Ser Ser Pro Asn Lys Glu Lys Glu Leu Ala Leu Arg Lys Asn Ala Ala 
305                 310                 315                 320 


Cys Gln Ser Asp Phe Ala Asp Leu Cys Thr Lys Gly Val Gln Thr Met 
                325                 330                 335     


Glu Asp Phe Lys Pro Glu Glu Tyr Pro Leu Thr Pro Glu Thr Ile Met 
            340                 345                 350         


Cys Tyr Glu Asn Lys Trp Glu Glu Pro Gly His Leu Thr Leu Asp Leu 
        355                 360                 365             


Gln Ser Gln Lys Gln Asp Arg His Gly Glu Ala Gly Ile Leu Asn Pro 
    370                 375                 380                 


Ile Met Glu Arg Glu Glu Lys Phe Val Thr Asp Glu Glu Leu His Val 
385                 390                 395                 400 


Val Lys Gln Glu Val Glu Lys Leu Glu Asp Glu Trp Glu Arg Glu Glu 
                405                 410                 415     


Leu Asp Lys Lys Gln Lys Glu Lys Ala Ser Leu Leu Glu Arg Glu Glu 
            420                 425                 430         


Lys Pro Glu Trp Glu Thr Gly Arg Tyr Gln Leu Gly Met Tyr Pro Ile 
        435                 440                 445             


Gln Asn Met Asp Lys Leu Gln Gly Glu Glu Glu Glu Arg Leu Lys Arg 
    450                 455                 460                 


Glu Met Leu Leu Ala Lys Leu Asn Glu Ile Asp Arg Glu Leu Gln Asp 
465                 470                 475                 480 


Ser Arg Asn Leu Lys Tyr Pro Val Leu Pro Leu Leu Pro Asp Phe Glu 
                485                 490                 495     


Ser Lys Leu His Ser Arg Glu Arg Ser Pro Lys Thr Tyr Arg Phe Ser 
            500                 505                 510         


Glu Ser Ser Glu Arg Leu Phe Asn Gly His His Leu Gln Asp Ile Ser 
        515                 520                 525             


Phe Ser Thr Pro Lys Gly Glu Gly Gln Asn Ser Gly Asn Val Arg Ser 
    530                 535                 540                 


Pro Ala Ser Pro Asn Glu Phe Ala Phe Gly Ser Tyr Val Pro Ser Phe 
545                 550                 555                 560 


Ala Lys Thr Ser Glu Arg Ser Asn Pro Phe Ser Gln Lys Ser Ser Phe 
                565                 570                 575     


Leu Asp Phe Gln Arg Asn Ser Met Glu Lys Leu Ser Lys Asp Gly Val 
            580                 585                 590         


Asp Leu Ile Thr Arg Lys Glu Lys Lys Ala Asn Leu Met Glu Gln Leu 
        595                 600                 605             


Phe Gly Ala Ser Gly Ser Ser Thr Ile Ser Ser Lys Ser Ser Gly Pro 
    610                 615                 620                 


Asn Ser Val Ala Ser Ser Lys Gly Asp Ile Asp Pro Leu Asn Phe Leu 
625                 630                 635                 640 


Pro Gly Asn Lys Gly Ser Arg Asp Gln Glu His Asp Glu Asp Glu Gly 
                645                 650                 655     


Phe Phe Leu Ser Glu Gly Arg Ser Phe Asn Pro Asn Arg His Arg Leu 
            660                 665                 670         


Lys His Ala Asp Asp Lys Pro Ala Val Lys Ala Ala Asp Ser Val Glu 
        675                 680                 685             


Asp Glu Ile Glu Glu Val Ala Leu Arg 
    690                 695         


<210>  600
<211>  173
<212>  PRT
<213>  Homo sapiens

<400>  600

Met Asp Val Thr Ile Gln His Pro Trp Phe Lys Arg Thr Leu Gly Pro 
1               5                   10                  15      


Phe Tyr Pro Ser Arg Leu Phe Asp Gln Phe Phe Gly Glu Gly Leu Phe 
            20                  25                  30          


Glu Tyr Asp Leu Leu Pro Phe Leu Ser Ser Thr Ile Ser Pro Tyr Tyr 
        35                  40                  45              


Arg Gln Ser Leu Phe Arg Thr Val Leu Asp Ser Gly Ile Ser Glu Val 
    50                  55                  60                  


Arg Ser Asp Arg Asp Lys Phe Val Ile Phe Leu Asp Val Lys His Phe 
65                  70                  75                  80  


Ser Pro Glu Asp Leu Thr Val Lys Val Gln Asp Asp Phe Val Glu Ile 
                85                  90                  95      


His Gly Lys His Asn Glu Arg Gln Asp Asp His Gly Tyr Ile Ser Arg 
            100                 105                 110         


Glu Phe His Arg Arg Tyr Arg Leu Pro Ser Asn Val Asp Gln Ser Ala 
        115                 120                 125             


Leu Ser Cys Ser Leu Ser Ala Asp Gly Met Leu Thr Phe Cys Gly Pro 
    130                 135                 140                 


Lys Ile Gln Thr Gly Leu Asp Ala Thr His Ala Glu Arg Ala Ile Pro 
145                 150                 155                 160 


Val Ser Arg Glu Glu Lys Pro Thr Ser Ala Pro Ser Ser 
                165                 170             


<210>  601
<211>  5384
<212>  DNA
<213>  Homo sapiens

<400>  601
aaaatgttgg agatctgcct gaagctggtg ggctgcaaat ccaagaaggg gctgtcctcg       60

tcctccagct gttatctgga agaagccctt cagcggccag tagcatctga ctttgagcct      120

cagggtctga gtgaagccgc tcgttggaac tccaaggaaa accttctcgc tggacccagt      180

gaaaatgacc ccaacctttt cgttgcactg tatgattttg tggccagtgg agataacact      240

ctaagcataa ctaaaggtga aaagctccgg gtcttaggct ataatcacaa tggggaatgg      300

tgtgaagccc aaaccaaaaa tggccaaggc tgggtcccaa gcaactacat cacgccagtc      360

aacagtctgg agaaacactc ctggtaccat gggcctgtgt cccgcaatgc cgctgagtat      420

ctgctgagca gcgggatcaa tggcagcttc ttggtgcgtg agagtgagag cagtcctggc      480

cagaggtcca tctcgctgag atacgaaggg agggtgtacc attacaggat caacactgct      540

tctgatggca agctctacgt ctcctccgag agccgcttca acaccctggc cgagttggtt      600

catcatcatt caacggtggc cgacgggctc atcaccacgc tccattatcc agccccaaag      660

cgcaacaagc ccactgtcta tggtgtgtcc cccaactacg acaagtggga gatggaacgc      720

acggacatca ccatgaagca caagctgggc gggggccagt acggggaggt gtacgagggc      780

gtgtggaaga aatacagcct gacggtggcc gtgaagacct tgaaggagga caccatggag      840

gtggaagagt tcttgaaaga agctgcagtc atgaaagaga tcaaacaccc taacctggtg      900

cagctccttg gggtctgcac ccgggagccc ccgttctata tcatcactga gttcatgacc      960

tacgggaacc tcctggacta cctgagggag tgcaaccggc aggaggtgaa cgccgtggtg     1020

ctgctgtaca tggccactca gatctcgtca gccatggagt acctggagaa gaaaaacttc     1080

atccacagag atcttgctgc ccgaaactgc ctggtagggg agaaccactt ggtgaaggta     1140

gctgattttg gcctgagcag gttgatgaca ggggacacct acacagccca tgctggagcc     1200

aagttcccca tcaaatggac tgcacccgag agcctggcct acaacaagtt ctccatcaag     1260

tccgacgtct gggcatttgg agtattgctt tgggaaattg ctacctatgg catgtcccct     1320

tacccgggaa ttgacctgtc ccaggtgtat gagctgctag agaaggacta ccgcatggag     1380

cgcccagaag gctgcccaga gaaggtctat gaactcatgc gagcatgttg gcagtggaat     1440

ccctctgacc ggccctcctt tgctgaaatc caccaagcct ttgaaacaat gttccaggaa     1500

tccagtatct cagacgaagt ggaaaaggag ctggggaaac aaggcgtccg tggggctgtg     1560

agtaccttgc tgcaggcccc agagctgccc accaagacga ggacctccag gagagctgca     1620

gagcacagag acaccactga cgtgcctgag atgcctcact ccaagggcca gggagagagc     1680

gatcctctgg accatgagcc tgccgtgtct ccattgctcc ctcgaaaaga gcgaggtccc     1740

ccggagggcg gcctgaatga agatgagcgc cttctcccca aagacaaaaa gaccaacttg     1800

ttcagcgcct tgatcaagaa gaagaagaag acagccccaa cccctcccaa acgcagcagc     1860

tccttccggg agatggacgg ccagccggag cgcagagggg ccggcgagga agagggccga     1920

gacatcagca acggggcact ggctttcacc cccttggaca cagctgaccc agccaagtcc     1980

ccaaagccca gcaatggggc tggggtcccc aatggagccc tccgggagtc cgggggctca     2040

ggcttccggt ctccccacct gtggaagaag tccagcacgc tgaccagcag ccgcctagcc     2100

accggcgagg aggagggcgg tggcagctcc agcaagcgct tcctgcgctc ttgctccgcc     2160

tcctgcgttc cccatggggc caaggacacg gagtggaggt cagtcacgct gcctcgggac     2220

ttgcagtcca cgggaagaca gtttgactcg tccacatttg gagggcacaa aagtgagaag     2280

ccggctctgc ctcggaagag ggcaggggag aacaggtctg accaggtgac ccgaggcaca     2340

gtaacgcctc cccccaggct ggtgaaaaag aatgaggaag ctgctgatga ggtcttcaaa     2400

gacatcatgg agtccagccc gggctccagc ccgcccaacc tgactccaaa acccctccgg     2460

cggcaggtca ccgtggcccc tgcctcgggc ctcccccaca aggaagaagc tggaaagggc     2520

agtgccttag ggacccctgc tgcagctgag ccagtgaccc ccaccagcaa agcaggctca     2580

ggtgcaccag ggggcaccag caagggcccc gccgaggagt ccagagtgag gaggcacaag     2640

cactcctctg agtcgccagg gagggacaag gggaaattgt ccaggctcaa acctgccccg     2700

ccgcccccac cagcagcctc tgcagggaag gctggaggaa agccctcgca gagcccgagc     2760

caggaggcgg ccggggaggc agtcctgggc gcaaagacaa aagccacgag tctggttgat     2820

gctgtgaaca gtgacgctgc caagcccagc cagccgggag agggcctcaa aaagcccgtg     2880

ctcccggcca ctccaaagcc acagtccgcc aagccgtcgg ggacccccat cagcccagcc     2940

cccgttccct ccacgttgcc atcagcatcc tcggccctgg caggggacca gccgtcttcc     3000

accgccttca tccctctcat atcaacccga gtgtctcttc ggaaaacccg ccagcctcca     3060

gagcggatcg ccagcggcgc catcaccaag ggcgtggtcc tggacagcac cgaggcgctg     3120

tgcctcgcca tctctaggaa ctccgagcag atggccagcc acagcgcagt gctggaggcc     3180

ggcaaaaacc tctacacgtt ctgcgtgagc tatgtggatt ccatccagca aatgaggaac     3240

aagtttgcct tccgagaggc catcaacaaa ctggagaata atctccggga gcttcagatc     3300

tgcccggcga cagcaggcag tggtccagcg gccactcagg acttcagcaa gctcctcagt     3360

tcggtgaagg aaatcagtga catagtgcag aggtagcagc agtcaggggt caggtgtcag     3420

gcccgtcgga gctgcctgca gcacatgcgg gctcgcccat acccgtgaca gtggctgaca     3480

agggactagt gagtcagcac cttggcccag gagctctgcg ccaggcagag ctgagggccc     3540

tgtggagtcc agctctacta cctacgtttg caccgcctgc cctcccgcac cttcctcctc     3600

cccgctccgt ctctgtcctc gaattttatc tgtggagttc ctgctccgtg gactgcagtc     3660

ggcatgccag gacccgccag ccccgctccc acctagtgcc ccagactgag ctctccaggc     3720

caggtgggaa cggctgatgt ggactgtctt tttcattttt ttctctctgg agcccctcct     3780

cccccggctg ggcctccttc ttccacttct ccaagaatgg aagcctgaac tgaggccttg     3840

tgtgtcaggc cctctgcctg cactccctgg ccttgcccgt cgtgtgctga agacatgttt     3900

caagaaccgc atttcgggaa gggcatgcac gggcatgcac acggctggtc actctgccct     3960

ctgctgctgc ccggggtggg gtgcactcgc catttcctca cgtgcaggac agctcttgat     4020

ttgggtggaa aacagggtgc taaagccaac cagcctttgg gtcctgggca ggtgggagct     4080

gaaaaggatc gaggcatggg gcatgtcctt tccatctgtc cacatcccca gagcccagct     4140

cttgctctct tgtgacgtgc actgtgaatc ctggcaagaa agcttgagtc tcaagggtgg     4200

caggtcactg tcactgccga catccctccc ccagcagaat ggaggcaggg gacaagggag     4260

gcagtggcta gtggggtgaa cagctggtgc caaatagccc cagactgggc ccaggcaggt     4320

ctgcaagggc ccagagtgaa ccgtcctttc acacatctgg gtgccctgaa agggcccttc     4380

ccctccccca ctcctctaag acaaagtaga ttcttacaag gccctttcct ttggaacaag     4440

acagccttca cttttctgag ttcttgaagc atttcaaagc cctgcctctg tgtagccgcc     4500

ctgagagaga atagagctgc cactgggcac ctgcgcacag gtgggaggaa agggcctggc     4560

cagtcctggt cctggctgca ctcttgaact gggcgaatgt cttatttaat taccgtgagt     4620

gacatagcct catgttctgt gggggtcatc agggagggtt aggaaaacca caaacggagc     4680

ccctgaaagc ctcacgtatt tcacagagca cgcctgccat cttctccccg aggctgcccc     4740

aggccggagc ccagatacgg gggctgtgac tctgggcagg gacccggggt ctcctggacc     4800

ttgacagagc agctaactcc gagagcagtg ggcaggtggc cgcccctgag gcttcacgcc     4860

gggagaagcc accttcccac cccttcatac cgcctcgtgc cagcagcctc gcacaggccc     4920

tagctttacg ctcatcacct aaacttgtac tttatttttc tgatagaaat ggtttcctct     4980

ggatcgtttt atgcggttct tacagcacat cacctctttg cccccgacgg ctgtgacgca     5040

gccggaggga ggcactagtc accgacagcg gccttgaaga cagagcaaag cgcccaccca     5100

ggtcccccga ctgcctgtct ccatgaggta ctggtccctt ccttttgtta acgtgatgtg     5160

ccactatatt ttacacgtat ctcttggtat gcatctttta tagacgctct tttctaagtg     5220

gcgtgtgcat agcgtcctgc cctgccccct cgggggcctg tggtggctcc ccctctgctt     5280

ctcggggtcc agtgcatttt gtttctgtat atgattctct gtggtttttt ttgaatccaa     5340

atctgtcctc tgtagtattt tttaaataaa tcagtgttta catt                      5384


<210>  602
<211>  1130
<212>  PRT
<213>  Homo sapiens

<400>  602

Met Leu Glu Ile Cys Leu Lys Leu Val Gly Cys Lys Ser Lys Lys Gly 
1               5                   10                  15      


Leu Ser Ser Ser Ser Ser Cys Tyr Leu Glu Glu Ala Leu Gln Arg Pro 
            20                  25                  30          


Val Ala Ser Asp Phe Glu Pro Gln Gly Leu Ser Glu Ala Ala Arg Trp 
        35                  40                  45              


Asn Ser Lys Glu Asn Leu Leu Ala Gly Pro Ser Glu Asn Asp Pro Asn 
    50                  55                  60                  


Leu Phe Val Ala Leu Tyr Asp Phe Val Ala Ser Gly Asp Asn Thr Leu 
65                  70                  75                  80  


Ser Ile Thr Lys Gly Glu Lys Leu Arg Val Leu Gly Tyr Asn His Asn 
                85                  90                  95      


Gly Glu Trp Cys Glu Ala Gln Thr Lys Asn Gly Gln Gly Trp Val Pro 
            100                 105                 110         


Ser Asn Tyr Ile Thr Pro Val Asn Ser Leu Glu Lys His Ser Trp Tyr 
        115                 120                 125             


His Gly Pro Val Ser Arg Asn Ala Ala Glu Tyr Leu Leu Ser Ser Gly 
    130                 135                 140                 


Ile Asn Gly Ser Phe Leu Val Arg Glu Ser Glu Ser Ser Pro Gly Gln 
145                 150                 155                 160 


Arg Ser Ile Ser Leu Arg Tyr Glu Gly Arg Val Tyr His Tyr Arg Ile 
                165                 170                 175     


Asn Thr Ala Ser Asp Gly Lys Leu Tyr Val Ser Ser Glu Ser Arg Phe 
            180                 185                 190         


Asn Thr Leu Ala Glu Leu Val His His His Ser Thr Val Ala Asp Gly 
        195                 200                 205             


Leu Ile Thr Thr Leu His Tyr Pro Ala Pro Lys Arg Asn Lys Pro Thr 
    210                 215                 220                 


Val Tyr Gly Val Ser Pro Asn Tyr Asp Lys Trp Glu Met Glu Arg Thr 
225                 230                 235                 240 


Asp Ile Thr Met Lys His Lys Leu Gly Gly Gly Gln Tyr Gly Lys Val 
                245                 250                 255     


Tyr Glu Gly Val Trp Lys Lys Tyr Ser Leu Thr Val Ala Val Lys Thr 
            260                 265                 270         


Leu Lys Glu Asp Thr Met Glu Val Glu Glu Phe Leu Lys Glu Ala Ala 
        275                 280                 285             


Val Met Lys Glu Ile Lys His Pro Asn Leu Val Gln Leu Leu Gly Val 
    290                 295                 300                 


Cys Thr Arg Glu Pro Pro Phe Tyr Ile Ile Thr Glu Phe Met Thr Tyr 
305                 310                 315                 320 


Gly Asn Leu Leu Asp Tyr Leu Arg Glu Cys Asn Arg Gln Glu Val Asn 
                325                 330                 335     


Ala Val Val Leu Leu Tyr Met Ala Thr Gln Ile Ser Ser Ala Met Glu 
            340                 345                 350         


Tyr Leu Glu Lys Lys Asn Phe Ile His Arg Asp Leu Ala Ala Arg Asn 
        355                 360                 365             


Cys Leu Val Gly Glu Asn His Leu Val Lys Val Ala Asp Phe Gly Leu 
    370                 375                 380                 


Ser Arg Leu Met Thr Gly Asp Thr Tyr Thr Ala His Ala Gly Ala Lys 
385                 390                 395                 400 


Phe Pro Ile Lys Trp Thr Ala Pro Glu Ser Leu Ala Tyr Asn Lys Phe 
                405                 410                 415     


Ser Ile Lys Ser Asp Val Trp Ala Phe Gly Val Leu Leu Trp Glu Ile 
            420                 425                 430         


Ala Thr Tyr Gly Met Ser Pro Tyr Pro Gly Ile Asp Leu Ser Gln Val 
        435                 440                 445             


Tyr Glu Leu Leu Glu Lys Asp Tyr Arg Met Glu Arg Pro Glu Gly Cys 
    450                 455                 460                 


Pro Glu Lys Val Tyr Glu Leu Met Arg Ala Cys Trp Gln Trp Asn Pro 
465                 470                 475                 480 


Ser Asp Arg Pro Ser Phe Ala Glu Ile His Gln Ala Phe Glu Thr Met 
                485                 490                 495     


Phe Gln Glu Ser Ser Ile Ser Asp Glu Val Glu Lys Glu Leu Gly Lys 
            500                 505                 510         


Gln Gly Val Arg Gly Ala Val Ser Thr Leu Leu Gln Ala Pro Glu Leu 
        515                 520                 525             


Pro Thr Lys Thr Arg Thr Ser Arg Arg Ala Ala Glu His Arg Asp Thr 
    530                 535                 540                 


Thr Asp Val Pro Glu Met Pro His Ser Lys Gly Gln Gly Glu Ser Asp 
545                 550                 555                 560 


Pro Leu Asp His Glu Pro Ala Val Ser Pro Leu Leu Pro Arg Lys Glu 
                565                 570                 575     


Arg Gly Pro Pro Glu Gly Gly Leu Asn Glu Asp Glu Arg Leu Leu Pro 
            580                 585                 590         


Lys Asp Lys Lys Thr Asn Leu Phe Ser Ala Leu Ile Lys Lys Lys Lys 
        595                 600                 605             


Lys Thr Ala Pro Thr Pro Pro Lys Arg Ser Ser Ser Phe Arg Glu Met 
    610                 615                 620                 


Asp Gly Gln Pro Glu Arg Arg Gly Ala Gly Glu Glu Glu Gly Arg Asp 
625                 630                 635                 640 


Ile Ser Asn Gly Ala Leu Ala Phe Thr Pro Leu Asp Thr Ala Asp Pro 
                645                 650                 655     


Ala Lys Ser Pro Lys Pro Ser Asn Gly Ala Gly Val Pro Asn Gly Ala 
            660                 665                 670         


Leu Arg Glu Ser Gly Gly Ser Gly Phe Arg Ser Pro His Leu Trp Lys 
        675                 680                 685             


Lys Ser Ser Thr Leu Thr Ser Ser Arg Leu Ala Thr Gly Glu Glu Glu 
    690                 695                 700                 


Gly Gly Gly Ser Ser Ser Lys Arg Phe Leu Arg Ser Cys Ser Ala Ser 
705                 710                 715                 720 


Cys Val Pro His Gly Ala Lys Asp Thr Glu Trp Arg Ser Val Thr Leu 
                725                 730                 735     


Pro Arg Asp Leu Gln Ser Thr Gly Arg Gln Phe Asp Ser Ser Thr Phe 
            740                 745                 750         


Gly Gly His Lys Ser Glu Lys Pro Ala Leu Pro Arg Lys Arg Ala Gly 
        755                 760                 765             


Glu Asn Arg Ser Asp Gln Val Thr Arg Gly Thr Val Thr Pro Pro Pro 
    770                 775                 780                 


Arg Leu Val Lys Lys Asn Glu Glu Ala Ala Asp Glu Val Phe Lys Asp 
785                 790                 795                 800 


Ile Met Glu Ser Ser Pro Gly Ser Ser Pro Pro Asn Leu Thr Pro Lys 
                805                 810                 815     


Pro Leu Arg Arg Gln Val Thr Val Ala Pro Ala Ser Gly Leu Pro His 
            820                 825                 830         


Lys Glu Glu Ala Gly Lys Gly Ser Ala Leu Gly Thr Pro Ala Ala Ala 
        835                 840                 845             


Glu Pro Val Thr Pro Thr Ser Lys Ala Gly Ser Gly Ala Pro Gly Gly 
    850                 855                 860                 


Thr Ser Lys Gly Pro Ala Glu Glu Ser Arg Val Arg Arg His Lys His 
865                 870                 875                 880 


Ser Ser Glu Ser Pro Gly Arg Asp Lys Gly Lys Leu Ser Arg Leu Lys 
                885                 890                 895     


Pro Ala Pro Pro Pro Pro Pro Ala Ala Ser Ala Gly Lys Ala Gly Gly 
            900                 905                 910         


Lys Pro Ser Gln Ser Pro Ser Gln Glu Ala Ala Gly Glu Ala Val Leu 
        915                 920                 925             


Gly Ala Lys Thr Lys Ala Thr Ser Leu Val Asp Ala Val Asn Ser Asp 
    930                 935                 940                 


Ala Ala Lys Pro Ser Gln Pro Gly Glu Gly Leu Lys Lys Pro Val Leu 
945                 950                 955                 960 


Pro Ala Thr Pro Lys Pro Gln Ser Ala Lys Pro Ser Gly Thr Pro Ile 
                965                 970                 975     


Ser Pro Ala Pro Val Pro Ser Thr Leu Pro Ser Ala Ser Ser Ala Leu 
            980                 985                 990         


Ala Gly Asp Gln Pro Ser Ser Thr  Ala Phe Ile Pro Leu  Ile Ser Thr 
        995                 1000                 1005             


Arg Val  Ser Leu Arg Lys Thr  Arg Gln Pro Pro Glu  Arg Ile Ala 
    1010                 1015                 1020             


Ser Gly  Ala Ile Thr Lys Gly  Val Val Leu Asp Ser  Thr Glu Ala 
    1025                 1030                 1035             


Leu Cys  Leu Ala Ile Ser Arg  Asn Ser Glu Gln Met  Ala Ser His 
    1040                 1045                 1050             


Ser Ala  Val Leu Glu Ala Gly  Lys Asn Leu Tyr Thr  Phe Cys Val 
    1055                 1060                 1065             


Ser Tyr  Val Asp Ser Ile Gln  Gln Met Arg Asn Lys  Phe Ala Phe 
    1070                 1075                 1080             


Arg Glu  Ala Ile Asn Lys Leu  Glu Asn Asn Leu Arg  Glu Leu Gln 
    1085                 1090                 1095             


Ile Cys  Pro Ala Thr Ala Gly  Ser Gly Pro Ala Ala  Thr Gln Asp 
    1100                 1105                 1110             


Phe Ser  Lys Leu Leu Ser Ser  Val Lys Glu Ile Ser  Asp Ile Val 
    1115                 1120                 1125             


Gln Arg  
    1130 


<210>  603
<211>  1130
<212>  PRT
<213>  Homo sapiens

<400>  603

Met Leu Glu Ile Cys Leu Lys Leu Val Gly Cys Lys Ser Lys Lys Gly 
1               5                   10                  15      


Leu Ser Ser Ser Ser Ser Cys Tyr Leu Glu Glu Ala Leu Gln Arg Pro 
            20                  25                  30          


Val Ala Ser Asp Phe Glu Pro Gln Gly Leu Ser Glu Ala Ala Arg Trp 
        35                  40                  45              


Asn Ser Lys Glu Asn Leu Leu Ala Gly Pro Ser Glu Asn Asp Pro Asn 
    50                  55                  60                  


Leu Phe Val Ala Leu Tyr Asp Phe Val Ala Ser Gly Asp Asn Thr Leu 
65                  70                  75                  80  


Ser Ile Thr Lys Gly Glu Lys Leu Arg Val Leu Gly Tyr Asn His Asn 
                85                  90                  95      


Gly Glu Trp Cys Glu Ala Gln Thr Lys Asn Gly Gln Gly Trp Val Pro 
            100                 105                 110         


Ser Asn Tyr Ile Thr Pro Val Asn Ser Leu Glu Lys His Ser Trp Tyr 
        115                 120                 125             


His Gly Pro Val Ser Arg Asn Ala Ala Glu Tyr Leu Leu Ser Ser Gly 
    130                 135                 140                 


Ile Asn Gly Ser Phe Leu Val Arg Glu Ser Glu Ser Ser Pro Gly Gln 
145                 150                 155                 160 


Arg Ser Ile Ser Leu Arg Tyr Glu Gly Arg Val Tyr His Tyr Arg Ile 
                165                 170                 175     


Asn Thr Ala Ser Asp Gly Lys Leu Tyr Val Ser Ser Glu Ser Arg Phe 
            180                 185                 190         


Asn Thr Leu Ala Glu Leu Val His His His Ser Thr Val Ala Asp Gly 
        195                 200                 205             


Leu Ile Thr Thr Leu His Tyr Pro Ala Pro Lys Arg Asn Lys Pro Thr 
    210                 215                 220                 


Val Tyr Gly Val Ser Pro Asn Tyr Asp Lys Trp Glu Met Glu Arg Thr 
225                 230                 235                 240 


Asp Ile Thr Met Lys His Lys Leu Gly Gly Gly Gln Tyr Gly Lys Val 
                245                 250                 255     


Tyr Glu Gly Val Trp Lys Lys Tyr Ser Leu Thr Val Ala Val Lys Thr 
            260                 265                 270         


Leu Lys Glu Asp Thr Met Glu Val Glu Glu Phe Leu Lys Glu Ala Ala 
        275                 280                 285             


Val Met Lys Glu Ile Lys His Pro Asn Leu Val Gln Leu Leu Gly Val 
    290                 295                 300                 


Cys Thr Arg Glu Pro Pro Phe Tyr Ile Ile Thr Glu Phe Met Thr Tyr 
305                 310                 315                 320 


Gly Asn Leu Leu Asp Tyr Leu Arg Glu Cys Asn Arg Gln Glu Val Asn 
                325                 330                 335     


Ala Val Val Leu Leu Tyr Met Ala Thr Gln Ile Ser Ser Ala Met Glu 
            340                 345                 350         


Tyr Leu Glu Lys Lys Asn Phe Ile His Arg Asp Leu Ala Ala Arg Asn 
        355                 360                 365             


Cys Leu Val Gly Glu Asn His Leu Val Lys Val Ala Asp Phe Gly Leu 
    370                 375                 380                 


Ser Arg Leu Met Thr Gly Asp Thr Tyr Thr Ala His Ala Gly Ala Lys 
385                 390                 395                 400 


Phe Pro Ile Lys Trp Thr Ala Pro Glu Ser Leu Ala Tyr Asn Lys Phe 
                405                 410                 415     


Ser Ile Lys Ser Asp Val Trp Ala Phe Gly Val Leu Leu Trp Glu Ile 
            420                 425                 430         


Ala Thr Tyr Gly Met Ser Pro Tyr Pro Gly Ile Asp Leu Ser Gln Val 
        435                 440                 445             


Tyr Glu Leu Leu Glu Lys Asp Tyr Arg Met Glu Arg Pro Glu Gly Cys 
    450                 455                 460                 


Pro Glu Lys Val Tyr Glu Leu Met Arg Ala Cys Trp Gln Trp Asn Pro 
465                 470                 475                 480 


Ser Asp Arg Pro Ser Phe Ala Glu Ile His Gln Ala Phe Glu Thr Met 
                485                 490                 495     


Phe Gln Glu Ser Ser Ile Ser Asp Glu Val Glu Lys Glu Leu Gly Lys 
            500                 505                 510         


Gln Gly Val Arg Gly Ala Val Ser Thr Leu Leu Gln Ala Pro Glu Leu 
        515                 520                 525             


Pro Thr Lys Thr Arg Thr Ser Arg Arg Ala Ala Glu His Arg Asp Thr 
    530                 535                 540                 


Thr Asp Val Pro Glu Met Pro His Ser Lys Gly Gln Gly Glu Ser Asp 
545                 550                 555                 560 


Pro Leu Asp His Glu Pro Ala Val Ser Pro Leu Leu Pro Arg Lys Glu 
                565                 570                 575     


Arg Gly Pro Pro Glu Gly Gly Leu Asn Glu Asp Glu Arg Leu Leu Pro 
            580                 585                 590         


Lys Asp Lys Lys Thr Asn Leu Phe Ser Ala Leu Ile Lys Lys Lys Lys 
        595                 600                 605             


Lys Thr Ala Pro Thr Pro Pro Lys Arg Ser Ser Ser Phe Arg Glu Met 
    610                 615                 620                 


Asp Gly Gln Pro Glu Arg Arg Gly Ala Gly Glu Glu Glu Gly Arg Asp 
625                 630                 635                 640 


Ile Ser Asn Gly Ala Leu Ala Phe Thr Pro Leu Asp Thr Ala Asp Pro 
                645                 650                 655     


Ala Lys Ser Pro Lys Pro Ser Asn Gly Ala Gly Val Pro Asn Gly Ala 
            660                 665                 670         


Leu Arg Glu Ser Gly Gly Ser Gly Phe Arg Ser Pro His Leu Trp Lys 
        675                 680                 685             


Lys Ser Ser Thr Leu Thr Ser Ser Arg Leu Ala Thr Gly Glu Glu Glu 
    690                 695                 700                 


Gly Gly Gly Ser Ser Ser Lys Arg Phe Leu Arg Ser Cys Ser Ala Ser 
705                 710                 715                 720 


Cys Val Pro His Gly Ala Lys Asp Thr Glu Trp Arg Ser Val Thr Leu 
                725                 730                 735     


Pro Arg Asp Leu Gln Ser Thr Gly Arg Gln Phe Asp Ser Ser Thr Phe 
            740                 745                 750         


Gly Gly His Lys Ser Glu Lys Pro Ala Leu Pro Arg Lys Arg Ala Gly 
        755                 760                 765             


Glu Asn Arg Ser Asp Gln Val Thr Arg Gly Thr Val Thr Pro Pro Pro 
    770                 775                 780                 


Arg Leu Val Lys Lys Asn Glu Glu Ala Ala Asp Glu Val Phe Lys Asp 
785                 790                 795                 800 


Ile Met Glu Ser Ser Pro Gly Ser Ser Pro Pro Asn Leu Thr Pro Lys 
                805                 810                 815     


Pro Leu Arg Arg Gln Val Thr Val Ala Pro Ala Ser Gly Leu Pro His 
            820                 825                 830         


Lys Glu Glu Ala Gly Lys Gly Ser Ala Leu Gly Thr Pro Ala Ala Ala 
        835                 840                 845             


Glu Pro Val Thr Pro Thr Ser Lys Ala Gly Ser Gly Ala Pro Gly Gly 
    850                 855                 860                 


Thr Ser Lys Gly Pro Ala Glu Glu Ser Arg Val Arg Arg His Lys His 
865                 870                 875                 880 


Ser Ser Glu Ser Pro Gly Arg Asp Lys Gly Lys Leu Ser Arg Leu Lys 
                885                 890                 895     


Pro Ala Pro Pro Pro Pro Pro Ala Ala Ser Ala Gly Lys Ala Gly Gly 
            900                 905                 910         


Lys Pro Ser Gln Ser Pro Ser Gln Glu Ala Ala Gly Glu Ala Val Leu 
        915                 920                 925             


Gly Ala Lys Thr Lys Ala Thr Ser Leu Val Asp Ala Val Asn Ser Asp 
    930                 935                 940                 


Ala Ala Lys Pro Ser Gln Pro Gly Glu Gly Leu Lys Lys Pro Val Leu 
945                 950                 955                 960 


Pro Ala Thr Pro Lys Pro Gln Ser Ala Lys Pro Ser Gly Thr Pro Ile 
                965                 970                 975     


Ser Pro Ala Pro Val Pro Ser Thr Leu Pro Ser Ala Ser Ser Ala Leu 
            980                 985                 990         


Ala Gly Asp Gln Pro Ser Ser Thr  Ala Phe Ile Pro Leu  Ile Ser Thr 
        995                 1000                 1005             


Arg Val  Ser Leu Arg Lys Thr  Arg Gln Pro Pro Glu  Arg Ile Ala 
    1010                 1015                 1020             


Ser Gly  Ala Ile Thr Lys Gly  Val Val Leu Asp Ser  Thr Glu Ala 
    1025                 1030                 1035             


Leu Cys  Leu Ala Ile Ser Arg  Asn Ser Glu Gln Met  Ala Ser His 
    1040                 1045                 1050             


Ser Ala  Val Leu Glu Ala Gly  Lys Asn Leu Tyr Thr  Phe Cys Val 
    1055                 1060                 1065             


Ser Tyr  Val Asp Ser Ile Gln  Gln Met Arg Asn Lys  Phe Ala Phe 
    1070                 1075                 1080             


Arg Glu  Ala Ile Asn Lys Leu  Glu Asn Asn Leu Arg  Glu Leu Gln 
    1085                 1090                 1095             


Ile Cys  Pro Ala Thr Ala Gly  Ser Gly Pro Ala Ala  Thr Gln Asp 
    1100                 1105                 1110             


Phe Ser  Lys Leu Leu Ser Ser  Val Lys Glu Ile Ser  Asp Ile Val 
    1115                 1120                 1125             


Gln Arg  
    1130 


<210>  604
<211>  5384
<212>  DNA
<213>  Homo sapiens

<400>  604
aaaatgttgg agatctgcct gaagctggtg ggctgcaaat ccaagaaggg gctgtcctcg       60

tcctccagct gttatctgga agaagccctt cagcggccag tagcatctga ctttgagcct      120

cagggtctga gtgaagccgc tcgttggaac tccaaggaaa accttctcgc tggacccagt      180

gaaaatgacc ccaacctttt cgttgcactg tatgattttg tggccagtgg agataacact      240

ctaagcataa ctaaaggtga aaagctccgg gtcttaggct ataatcacaa tggggaatgg      300

tgtgaagccc aaaccaaaaa tggccaaggc tgggtcccaa gcaactacat cacgccagtc      360

aacagtctgg agaaacactc ctggtaccat gggcctgtgt cccgcaatgc cgctgagtat      420

ctgctgagca gcgggatcaa tggcagcttc ttggtgcgtg agagtgagag cagtcctggc      480

cagaggtcca tctcgctgag atacgaaggg agggtgtacc attacaggat caacactgct      540

tctgatggca agctctacgt ctcctccgag agccgcttca acaccctggc cgagttggtt      600

catcatcatt caacggtggc cgacgggctc atcaccacgc tccattatcc agccccaaag      660

cgcaacaagc ccactgtcta tggtgtgtcc cccaactacg acaagtggga gatggaacgc      720

acggacatca ccatgaagca caagctgggc gggggccagt acggggaggt gtacgagggc      780

gtgtggaaga aatacagcct gacggtggcc gtgaagacct tgaaggagga caccatggag      840

gtggaagagt tcttgaaaga agctgcagtc atgaaagaga tcaaacaccc taacctggtg      900

cagctccttg gggtctgcac ccgggagccc ccgttctata tcatcactga gttcatgacc      960

tacgggaacc tcctggacta cctgagggag tgcaaccggc aggaggtgaa cgccgtggtg     1020

ctgctgtaca tggccactca gatctcgtca gccatggagt acctggagaa gaaaaacttc     1080

atccacagag atcttgctgc ccgaaactgc ctggtagggg agaaccactt ggtgaaggta     1140

gctgattttg gcctgagcag gttgatgaca ggggacacct acacagccca tgctggagcc     1200

aagttcccca tcaaatggac tgcacccgag agcctggcct acaacaagtt ctccatcaag     1260

tccgacgtct gggcatttgg agtattgctt tgggaaattg ctacctatgg catgtcccct     1320

tacccgggaa ttgacctgtc ccaggtgtat gagctgctag agaaggacta ccgcatggag     1380

cgcccagaag gctgcccaga gaaggtctat gaactcatgc gagcatgttg gcagtggaat     1440

ccctctgacc ggccctcctt tgctgaaatc caccaagcct ttgaaacaat gttccaggaa     1500

tccagtatct cagacgaagt ggaaaaggag ctggggaaac aaggcgtccg tggggctgtg     1560

agtaccttgc tgcaggcccc agagctgccc accaagacga ggacctccag gagagctgca     1620

gagcacagag acaccactga cgtgcctgag atgcctcact ccaagggcca gggagagagc     1680

gatcctctgg accatgagcc tgccgtgtct ccattgctcc ctcgaaaaga gcgaggtccc     1740

ccggagggcg gcctgaatga agatgagcgc cttctcccca aagacaaaaa gaccaacttg     1800

ttcagcgcct tgatcaagaa gaagaagaag acagccccaa cccctcccaa acgcagcagc     1860

tccttccggg agatggacgg ccagccggag cgcagagggg ccggcgagga agagggccga     1920

gacatcagca acggggcact ggctttcacc cccttggaca cagctgaccc agccaagtcc     1980

ccaaagccca gcaatggggc tggggtcccc aatggagccc tccgggagtc cgggggctca     2040

ggcttccggt ctccccacct gtggaagaag tccagcacgc tgaccagcag ccgcctagcc     2100

accggcgagg aggagggcgg tggcagctcc agcaagcgct tcctgcgctc ttgctccgcc     2160

tcctgcgttc cccatggggc caaggacacg gagtggaggt cagtcacgct gcctcgggac     2220

ttgcagtcca cgggaagaca gtttgactcg tccacatttg gagggcacaa aagtgagaag     2280

ccggctctgc ctcggaagag ggcaggggag aacaggtctg accaggtgac ccgaggcaca     2340

gtaacgcctc cccccaggct ggtgaaaaag aatgaggaag ctgctgatga ggtcttcaaa     2400

gacatcatgg agtccagccc gggctccagc ccgcccaacc tgactccaaa acccctccgg     2460

cggcaggtca ccgtggcccc tgcctcgggc ctcccccaca aggaagaagc tggaaagggc     2520

agtgccttag ggacccctgc tgcagctgag ccagtgaccc ccaccagcaa agcaggctca     2580

ggtgcaccag ggggcaccag caagggcccc gccgaggagt ccagagtgag gaggcacaag     2640

cactcctctg agtcgccagg gagggacaag gggaaattgt ccaggctcaa acctgccccg     2700

ccgcccccac cagcagcctc tgcagggaag gctggaggaa agccctcgca gagcccgagc     2760

caggaggcgg ccggggaggc agtcctgggc gcaaagacaa aagccacgag tctggttgat     2820

gctgtgaaca gtgacgctgc caagcccagc cagccgggag agggcctcaa aaagcccgtg     2880

ctcccggcca ctccaaagcc acagtccgcc aagccgtcgg ggacccccat cagcccagcc     2940

cccgttccct ccacgttgcc atcagcatcc tcggccctgg caggggacca gccgtcttcc     3000

accgccttca tccctctcat atcaacccga gtgtctcttc ggaaaacccg ccagcctcca     3060

gagcggatcg ccagcggcgc catcaccaag ggcgtggtcc tggacagcac cgaggcgctg     3120

tgcctcgcca tctctaggaa ctccgagcag atggccagcc acagcgcagt gctggaggcc     3180

ggcaaaaacc tctacacgtt ctgcgtgagc tatgtggatt ccatccagca aatgaggaac     3240

aagtttgcct tccgagaggc catcaacaaa ctggagaata atctccggga gcttcagatc     3300

tgcccggcga cagcaggcag tggtccagcg gccactcagg acttcagcaa gctcctcagt     3360

tcggtgaagg aaatcagtga catagtgcag aggtagcagc agtcaggggt caggtgtcag     3420

gcccgtcgga gctgcctgca gcacatgcgg gctcgcccat acccgtgaca gtggctgaca     3480

agggactagt gagtcagcac cttggcccag gagctctgcg ccaggcagag ctgagggccc     3540

tgtggagtcc agctctacta cctacgtttg caccgcctgc cctcccgcac cttcctcctc     3600

cccgctccgt ctctgtcctc gaattttatc tgtggagttc ctgctccgtg gactgcagtc     3660

ggcatgccag gacccgccag ccccgctccc acctagtgcc ccagactgag ctctccaggc     3720

caggtgggaa cggctgatgt ggactgtctt tttcattttt ttctctctgg agcccctcct     3780

cccccggctg ggcctccttc ttccacttct ccaagaatgg aagcctgaac tgaggccttg     3840

tgtgtcaggc cctctgcctg cactccctgg ccttgcccgt cgtgtgctga agacatgttt     3900

caagaaccgc atttcgggaa gggcatgcac gggcatgcac acggctggtc actctgccct     3960

ctgctgctgc ccggggtggg gtgcactcgc catttcctca cgtgcaggac agctcttgat     4020

ttgggtggaa aacagggtgc taaagccaac cagcctttgg gtcctgggca ggtgggagct     4080

gaaaaggatc gaggcatggg gcatgtcctt tccatctgtc cacatcccca gagcccagct     4140

cttgctctct tgtgacgtgc actgtgaatc ctggcaagaa agcttgagtc tcaagggtgg     4200

caggtcactg tcactgccga catccctccc ccagcagaat ggaggcaggg gacaagggag     4260

gcagtggcta gtggggtgaa cagctggtgc caaatagccc cagactgggc ccaggcaggt     4320

ctgcaagggc ccagagtgaa ccgtcctttc acacatctgg gtgccctgaa agggcccttc     4380

ccctccccca ctcctctaag acaaagtaga ttcttacaag gccctttcct ttggaacaag     4440

acagccttca cttttctgag ttcttgaagc atttcaaagc cctgcctctg tgtagccgcc     4500

ctgagagaga atagagctgc cactgggcac ctgcgcacag gtgggaggaa agggcctggc     4560

cagtcctggt cctggctgca ctcttgaact gggcgaatgt cttatttaat taccgtgagt     4620

gacatagcct catgttctgt gggggtcatc agggagggtt aggaaaacca caaacggagc     4680

ccctgaaagc ctcacgtatt tcacagagca cgcctgccat cttctccccg aggctgcccc     4740

aggccggagc ccagatacgg gggctgtgac tctgggcagg gacccggggt ctcctggacc     4800

ttgacagagc agctaactcc gagagcagtg ggcaggtggc cgcccctgag gcttcacgcc     4860

gggagaagcc accttcccac cccttcatac cgcctcgtgc cagcagcctc gcacaggccc     4920

tagctttacg ctcatcacct aaacttgtac tttatttttc tgatagaaat ggtttcctct     4980

ggatcgtttt atgcggttct tacagcacat cacctctttg cccccgacgg ctgtgacgca     5040

gccggaggga ggcactagtc accgacagcg gccttgaaga cagagcaaag cgcccaccca     5100

ggtcccccga ctgcctgtct ccatgaggta ctggtccctt ccttttgtta acgtgatgtg     5160

ccactatatt ttacacgtat ctcttggtat gcatctttta tagacgctct tttctaagtg     5220

gcgtgtgcat agcgtcctgc cctgccccct cgggggcctg tggtggctcc ccctctgctt     5280

ctcggggtcc agtgcatttt gtttctgtat atgattctct gtggtttttt ttgaatccaa     5340

atctgtcctc tgtagtattt tttaaataaa tcagtgttta catt                      5384


<210>  605
<211>  1130
<212>  PRT
<213>  Homo sapiens

<400>  605

Met Leu Glu Ile Cys Leu Lys Leu Val Gly Cys Lys Ser Lys Lys Gly 
1               5                   10                  15      


Leu Ser Ser Ser Ser Ser Cys Tyr Leu Glu Glu Ala Leu Gln Arg Pro 
            20                  25                  30          


Val Ala Ser Asp Phe Glu Pro Gln Gly Leu Ser Glu Ala Ala Arg Trp 
        35                  40                  45              


Asn Ser Lys Glu Asn Leu Leu Ala Gly Pro Ser Glu Asn Asp Pro Asn 
    50                  55                  60                  


Leu Phe Val Ala Leu Tyr Asp Phe Val Ala Ser Gly Asp Asn Thr Leu 
65                  70                  75                  80  


Ser Ile Thr Lys Gly Glu Lys Leu Arg Val Leu Gly Tyr Asn His Asn 
                85                  90                  95      


Gly Glu Trp Cys Glu Ala Gln Thr Lys Asn Gly Gln Gly Trp Val Pro 
            100                 105                 110         


Ser Asn Tyr Ile Thr Pro Val Asn Ser Leu Glu Lys His Ser Trp Tyr 
        115                 120                 125             


His Gly Pro Val Ser Arg Asn Ala Ala Glu Tyr Leu Leu Ser Ser Gly 
    130                 135                 140                 


Ile Asn Gly Ser Phe Leu Val Arg Glu Ser Glu Ser Ser Pro Gly Gln 
145                 150                 155                 160 


Arg Ser Ile Ser Leu Arg Tyr Glu Gly Arg Val Tyr His Tyr Arg Ile 
                165                 170                 175     


Asn Thr Ala Ser Asp Gly Lys Leu Tyr Val Ser Ser Glu Ser Arg Phe 
            180                 185                 190         


Asn Thr Leu Ala Glu Leu Val His His His Ser Thr Val Ala Asp Gly 
        195                 200                 205             


Leu Ile Thr Thr Leu His Tyr Pro Ala Pro Lys Arg Asn Lys Pro Thr 
    210                 215                 220                 


Val Tyr Gly Val Ser Pro Asn Tyr Asp Lys Trp Glu Met Glu Arg Thr 
225                 230                 235                 240 


Asp Ile Thr Met Lys His Lys Leu Gly Glu Gly Gln Tyr Gly Glu Val 
                245                 250                 255     


Tyr Glu Gly Val Trp Lys Lys Tyr Ser Leu Thr Val Ala Val Lys Thr 
            260                 265                 270         


Leu Lys Glu Asp Thr Met Glu Val Glu Glu Phe Leu Lys Glu Ala Ala 
        275                 280                 285             


Val Met Lys Glu Ile Lys His Pro Asn Leu Val Gln Leu Leu Gly Val 
    290                 295                 300                 


Cys Thr Arg Glu Pro Pro Phe Tyr Ile Ile Thr Glu Phe Met Thr Tyr 
305                 310                 315                 320 


Gly Asn Leu Leu Asp Tyr Leu Arg Glu Cys Asn Arg Gln Glu Val Asn 
                325                 330                 335     


Ala Val Val Leu Leu Tyr Met Ala Thr Gln Ile Ser Ser Ala Met Glu 
            340                 345                 350         


Tyr Leu Glu Lys Lys Asn Phe Ile His Arg Asp Leu Ala Ala Arg Asn 
        355                 360                 365             


Cys Leu Val Gly Glu Asn His Leu Val Lys Val Ala Asp Phe Gly Leu 
    370                 375                 380                 


Ser Arg Leu Met Thr Gly Asp Thr Tyr Thr Ala His Ala Gly Ala Lys 
385                 390                 395                 400 


Phe Pro Ile Lys Trp Thr Ala Pro Glu Ser Leu Ala Tyr Asn Lys Phe 
                405                 410                 415     


Ser Ile Lys Ser Asp Val Trp Ala Phe Gly Val Leu Leu Trp Glu Ile 
            420                 425                 430         


Ala Thr Tyr Gly Met Ser Pro Tyr Pro Gly Ile Asp Leu Ser Gln Val 
        435                 440                 445             


Tyr Glu Leu Leu Glu Lys Asp Tyr Arg Met Glu Arg Pro Glu Gly Cys 
    450                 455                 460                 


Pro Glu Lys Val Tyr Glu Leu Met Arg Ala Cys Trp Gln Trp Asn Pro 
465                 470                 475                 480 


Ser Asp Arg Pro Ser Phe Ala Glu Ile His Gln Ala Phe Glu Thr Met 
                485                 490                 495     


Phe Gln Glu Ser Ser Ile Ser Asp Glu Val Glu Lys Glu Leu Gly Lys 
            500                 505                 510         


Gln Gly Val Arg Gly Ala Val Ser Thr Leu Leu Gln Ala Pro Glu Leu 
        515                 520                 525             


Pro Thr Lys Thr Arg Thr Ser Arg Arg Ala Ala Glu His Arg Asp Thr 
    530                 535                 540                 


Thr Asp Val Pro Glu Met Pro His Ser Lys Gly Gln Gly Glu Ser Asp 
545                 550                 555                 560 


Pro Leu Asp His Glu Pro Ala Val Ser Pro Leu Leu Pro Arg Lys Glu 
                565                 570                 575     


Arg Gly Pro Pro Glu Gly Gly Leu Asn Glu Asp Glu Arg Leu Leu Pro 
            580                 585                 590         


Lys Asp Lys Lys Thr Asn Leu Phe Ser Ala Leu Ile Lys Lys Lys Lys 
        595                 600                 605             


Lys Thr Ala Pro Thr Pro Pro Lys Arg Ser Ser Ser Phe Arg Glu Met 
    610                 615                 620                 


Asp Gly Gln Pro Glu Arg Arg Gly Ala Gly Glu Glu Glu Gly Arg Asp 
625                 630                 635                 640 


Ile Ser Asn Gly Ala Leu Ala Phe Thr Pro Leu Asp Thr Ala Asp Pro 
                645                 650                 655     


Ala Lys Ser Pro Lys Pro Ser Asn Gly Ala Gly Val Pro Asn Gly Ala 
            660                 665                 670         


Leu Arg Glu Ser Gly Gly Ser Gly Phe Arg Ser Pro His Leu Trp Lys 
        675                 680                 685             


Lys Ser Ser Thr Leu Thr Ser Ser Arg Leu Ala Thr Gly Glu Glu Glu 
    690                 695                 700                 


Gly Gly Gly Ser Ser Ser Lys Arg Phe Leu Arg Ser Cys Ser Ala Ser 
705                 710                 715                 720 


Cys Val Pro His Gly Ala Lys Asp Thr Glu Trp Arg Ser Val Thr Leu 
                725                 730                 735     


Pro Arg Asp Leu Gln Ser Thr Gly Arg Gln Phe Asp Ser Ser Thr Phe 
            740                 745                 750         


Gly Gly His Lys Ser Glu Lys Pro Ala Leu Pro Arg Lys Arg Ala Gly 
        755                 760                 765             


Glu Asn Arg Ser Asp Gln Val Thr Arg Gly Thr Val Thr Pro Pro Pro 
    770                 775                 780                 


Arg Leu Val Lys Lys Asn Glu Glu Ala Ala Asp Glu Val Phe Lys Asp 
785                 790                 795                 800 


Ile Met Glu Ser Ser Pro Gly Ser Ser Pro Pro Asn Leu Thr Pro Lys 
                805                 810                 815     


Pro Leu Arg Arg Gln Val Thr Val Ala Pro Ala Ser Gly Leu Pro His 
            820                 825                 830         


Lys Glu Glu Ala Gly Lys Gly Ser Ala Leu Gly Thr Pro Ala Ala Ala 
        835                 840                 845             


Glu Pro Val Thr Pro Thr Ser Lys Ala Gly Ser Gly Ala Pro Gly Gly 
    850                 855                 860                 


Thr Ser Lys Gly Pro Ala Glu Glu Ser Arg Val Arg Arg His Lys His 
865                 870                 875                 880 


Ser Ser Glu Ser Pro Gly Arg Asp Lys Gly Lys Leu Ser Arg Leu Lys 
                885                 890                 895     


Pro Ala Pro Pro Pro Pro Pro Ala Ala Ser Ala Gly Lys Ala Gly Gly 
            900                 905                 910         


Lys Pro Ser Gln Ser Pro Ser Gln Glu Ala Ala Gly Glu Ala Val Leu 
        915                 920                 925             


Gly Ala Lys Thr Lys Ala Thr Ser Leu Val Asp Ala Val Asn Ser Asp 
    930                 935                 940                 


Ala Ala Lys Pro Ser Gln Pro Gly Glu Gly Leu Lys Lys Pro Val Leu 
945                 950                 955                 960 


Pro Ala Thr Pro Lys Pro Gln Ser Ala Lys Pro Ser Gly Thr Pro Ile 
                965                 970                 975     


Ser Pro Ala Pro Val Pro Ser Thr Leu Pro Ser Ala Ser Ser Ala Leu 
            980                 985                 990         


Ala Gly Asp Gln Pro Ser Ser Thr  Ala Phe Ile Pro Leu  Ile Ser Thr 
        995                 1000                 1005             


Arg Val  Ser Leu Arg Lys Thr  Arg Gln Pro Pro Glu  Arg Ile Ala 
    1010                 1015                 1020             


Ser Gly  Ala Ile Thr Lys Gly  Val Val Leu Asp Ser  Thr Glu Ala 
    1025                 1030                 1035             


Leu Cys  Leu Ala Ile Ser Arg  Asn Ser Glu Gln Met  Ala Ser His 
    1040                 1045                 1050             


Ser Ala  Val Leu Glu Ala Gly  Lys Asn Leu Tyr Thr  Phe Cys Val 
    1055                 1060                 1065             


Ser Tyr  Val Asp Ser Ile Gln  Gln Met Arg Asn Lys  Phe Ala Phe 
    1070                 1075                 1080             


Arg Glu  Ala Ile Asn Lys Leu  Glu Asn Asn Leu Arg  Glu Leu Gln 
    1085                 1090                 1095             


Ile Cys  Pro Ala Thr Ala Gly  Ser Gly Pro Ala Ala  Thr Gln Asp 
    1100                 1105                 1110             


Phe Ser  Lys Leu Leu Ser Ser  Val Lys Glu Ile Ser  Asp Ile Val 
    1115                 1120                 1125             


Gln Arg  
    1130 


<210>  606
<211>  1130
<212>  PRT
<213>  Homo sapiens

<400>  606

Met Leu Glu Ile Cys Leu Lys Leu Val Gly Cys Lys Ser Lys Lys Gly 
1               5                   10                  15      


Leu Ser Ser Ser Ser Ser Cys Tyr Leu Glu Glu Ala Leu Gln Arg Pro 
            20                  25                  30          


Val Ala Ser Asp Phe Glu Pro Gln Gly Leu Ser Glu Ala Ala Arg Trp 
        35                  40                  45              


Asn Ser Lys Glu Asn Leu Leu Ala Gly Pro Ser Glu Asn Asp Pro Asn 
    50                  55                  60                  


Leu Phe Val Ala Leu Tyr Asp Phe Val Ala Ser Gly Asp Asn Thr Leu 
65                  70                  75                  80  


Ser Ile Thr Lys Gly Glu Lys Leu Arg Val Leu Gly Tyr Asn His Asn 
                85                  90                  95      


Gly Glu Trp Cys Glu Ala Gln Thr Lys Asn Gly Gln Gly Trp Val Pro 
            100                 105                 110         


Ser Asn Tyr Ile Thr Pro Val Asn Ser Leu Glu Lys His Ser Trp Tyr 
        115                 120                 125             


His Gly Pro Val Ser Arg Asn Ala Ala Glu Tyr Leu Leu Ser Ser Gly 
    130                 135                 140                 


Ile Asn Gly Ser Phe Leu Val Arg Glu Ser Glu Ser Ser Pro Gly Gln 
145                 150                 155                 160 


Arg Ser Ile Ser Leu Arg Tyr Glu Gly Arg Val Tyr His Tyr Arg Ile 
                165                 170                 175     


Asn Thr Ala Ser Asp Gly Lys Leu Tyr Val Ser Ser Glu Ser Arg Phe 
            180                 185                 190         


Asn Thr Leu Ala Glu Leu Val His His His Ser Thr Val Ala Asp Gly 
        195                 200                 205             


Leu Ile Thr Thr Leu His Tyr Pro Ala Pro Lys Arg Asn Lys Pro Thr 
    210                 215                 220                 


Val Tyr Gly Val Ser Pro Asn Tyr Asp Lys Trp Glu Met Glu Arg Thr 
225                 230                 235                 240 


Asp Ile Thr Met Lys His Lys Leu Gly Glu Gly Gln Tyr Gly Glu Val 
                245                 250                 255     


Tyr Glu Gly Val Trp Lys Lys Tyr Ser Leu Thr Val Ala Val Lys Thr 
            260                 265                 270         


Leu Lys Glu Asp Thr Met Glu Val Glu Glu Phe Leu Lys Glu Ala Ala 
        275                 280                 285             


Val Met Lys Glu Ile Lys His Pro Asn Leu Val Gln Leu Leu Gly Val 
    290                 295                 300                 


Cys Thr Arg Glu Pro Pro Phe Tyr Ile Ile Thr Glu Phe Met Thr Tyr 
305                 310                 315                 320 


Gly Asn Leu Leu Asp Tyr Leu Arg Glu Cys Asn Arg Gln Glu Val Asn 
                325                 330                 335     


Ala Val Val Leu Leu Tyr Met Ala Thr Gln Ile Ser Ser Ala Met Glu 
            340                 345                 350         


Tyr Leu Glu Lys Lys Asn Phe Ile His Arg Asp Leu Ala Ala Arg Asn 
        355                 360                 365             


Cys Leu Val Gly Glu Asn His Leu Val Lys Val Ala Asp Phe Gly Leu 
    370                 375                 380                 


Ser Arg Leu Met Thr Gly Asp Thr Tyr Thr Ala His Ala Gly Ala Lys 
385                 390                 395                 400 


Phe Pro Ile Lys Trp Thr Ala Pro Glu Ser Leu Ala Tyr Asn Lys Phe 
                405                 410                 415     


Ser Ile Lys Ser Asp Val Trp Ala Phe Gly Val Leu Leu Trp Glu Ile 
            420                 425                 430         


Ala Thr Tyr Gly Met Ser Pro Tyr Pro Gly Ile Asp Leu Ser Gln Val 
        435                 440                 445             


Tyr Glu Leu Leu Glu Lys Asp Tyr Arg Met Glu Arg Pro Glu Gly Cys 
    450                 455                 460                 


Pro Glu Lys Val Tyr Glu Leu Met Arg Ala Cys Trp Gln Trp Asn Pro 
465                 470                 475                 480 


Ser Asp Arg Pro Ser Phe Ala Glu Ile His Gln Ala Phe Glu Thr Met 
                485                 490                 495     


Phe Gln Glu Ser Ser Ile Ser Asp Glu Val Glu Lys Glu Leu Gly Lys 
            500                 505                 510         


Gln Gly Val Arg Gly Ala Val Ser Thr Leu Leu Gln Ala Pro Glu Leu 
        515                 520                 525             


Pro Thr Lys Thr Arg Thr Ser Arg Arg Ala Ala Glu His Arg Asp Thr 
    530                 535                 540                 


Thr Asp Val Pro Glu Met Pro His Ser Lys Gly Gln Gly Glu Ser Asp 
545                 550                 555                 560 


Pro Leu Asp His Glu Pro Ala Val Ser Pro Leu Leu Pro Arg Lys Glu 
                565                 570                 575     


Arg Gly Pro Pro Glu Gly Gly Leu Asn Glu Asp Glu Arg Leu Leu Pro 
            580                 585                 590         


Lys Asp Lys Lys Thr Asn Leu Phe Ser Ala Leu Ile Lys Lys Lys Lys 
        595                 600                 605             


Lys Thr Ala Pro Thr Pro Pro Lys Arg Ser Ser Ser Phe Arg Glu Met 
    610                 615                 620                 


Asp Gly Gln Pro Glu Arg Arg Gly Ala Gly Glu Glu Glu Gly Arg Asp 
625                 630                 635                 640 


Ile Ser Asn Gly Ala Leu Ala Phe Thr Pro Leu Asp Thr Ala Asp Pro 
                645                 650                 655     


Ala Lys Ser Pro Lys Pro Ser Asn Gly Ala Gly Val Pro Asn Gly Ala 
            660                 665                 670         


Leu Arg Glu Ser Gly Gly Ser Gly Phe Arg Ser Pro His Leu Trp Lys 
        675                 680                 685             


Lys Ser Ser Thr Leu Thr Ser Ser Arg Leu Ala Thr Gly Glu Glu Glu 
    690                 695                 700                 


Gly Gly Gly Ser Ser Ser Lys Arg Phe Leu Arg Ser Cys Ser Ala Ser 
705                 710                 715                 720 


Cys Val Pro His Gly Ala Lys Asp Thr Glu Trp Arg Ser Val Thr Leu 
                725                 730                 735     


Pro Arg Asp Leu Gln Ser Thr Gly Arg Gln Phe Asp Ser Ser Thr Phe 
            740                 745                 750         


Gly Gly His Lys Ser Glu Lys Pro Ala Leu Pro Arg Lys Arg Ala Gly 
        755                 760                 765             


Glu Asn Arg Ser Asp Gln Val Thr Arg Gly Thr Val Thr Pro Pro Pro 
    770                 775                 780                 


Arg Leu Val Lys Lys Asn Glu Glu Ala Ala Asp Glu Val Phe Lys Asp 
785                 790                 795                 800 


Ile Met Glu Ser Ser Pro Gly Ser Ser Pro Pro Asn Leu Thr Pro Lys 
                805                 810                 815     


Pro Leu Arg Arg Gln Val Thr Val Ala Pro Ala Ser Gly Leu Pro His 
            820                 825                 830         


Lys Glu Glu Ala Gly Lys Gly Ser Ala Leu Gly Thr Pro Ala Ala Ala 
        835                 840                 845             


Glu Pro Val Thr Pro Thr Ser Lys Ala Gly Ser Gly Ala Pro Gly Gly 
    850                 855                 860                 


Thr Ser Lys Gly Pro Ala Glu Glu Ser Arg Val Arg Arg His Lys His 
865                 870                 875                 880 


Ser Ser Glu Ser Pro Gly Arg Asp Lys Gly Lys Leu Ser Arg Leu Lys 
                885                 890                 895     


Pro Ala Pro Pro Pro Pro Pro Ala Ala Ser Ala Gly Lys Ala Gly Gly 
            900                 905                 910         


Lys Pro Ser Gln Ser Pro Ser Gln Glu Ala Ala Gly Glu Ala Val Leu 
        915                 920                 925             


Gly Ala Lys Thr Lys Ala Thr Ser Leu Val Asp Ala Val Asn Ser Asp 
    930                 935                 940                 


Ala Ala Lys Pro Ser Gln Pro Gly Glu Gly Leu Lys Lys Pro Val Leu 
945                 950                 955                 960 


Pro Ala Thr Pro Lys Pro Gln Ser Ala Lys Pro Ser Gly Thr Pro Ile 
                965                 970                 975     


Ser Pro Ala Pro Val Pro Ser Thr Leu Pro Ser Ala Ser Ser Ala Leu 
            980                 985                 990         


Ala Gly Asp Gln Pro Ser Ser Thr  Ala Phe Ile Pro Leu  Ile Ser Thr 
        995                 1000                 1005             


Arg Val  Ser Leu Arg Lys Thr  Arg Gln Pro Pro Glu  Arg Ile Ala 
    1010                 1015                 1020             


Ser Gly  Ala Ile Thr Lys Gly  Val Val Leu Asp Ser  Thr Glu Ala 
    1025                 1030                 1035             


Leu Cys  Leu Ala Ile Ser Arg  Asn Ser Glu Gln Met  Ala Ser His 
    1040                 1045                 1050             


Ser Ala  Val Leu Glu Ala Gly  Lys Asn Leu Tyr Thr  Phe Cys Val 
    1055                 1060                 1065             


Ser Tyr  Val Asp Ser Ile Gln  Gln Met Arg Asn Lys  Phe Ala Phe 
    1070                 1075                 1080             


Arg Glu  Ala Ile Asn Lys Leu  Glu Asn Asn Leu Arg  Glu Leu Gln 
    1085                 1090                 1095             


Ile Cys  Pro Ala Thr Ala Gly  Ser Gly Pro Ala Ala  Thr Gln Asp 
    1100                 1105                 1110             


Phe Ser  Lys Leu Leu Ser Ser  Val Lys Glu Ile Ser  Asp Ile Val 
    1115                 1120                 1125             


Gln Arg  
    1130 


<210>  607
<211>  5384
<212>  DNA
<213>  Homo sapiens

<400>  607
aaaatgttgg agatctgcct gaagctggtg ggctgcaaat ccaagaaggg gctgtcctcg       60

tcctccagct gttatctgga agaagccctt cagcggccag tagcatctga ctttgagcct      120

cagggtctga gtgaagccgc tcgttggaac tccaaggaaa accttctcgc tggacccagt      180

gaaaatgacc ccaacctttt cgttgcactg tatgattttg tggccagtgg agataacact      240

ctaagcataa ctaaaggtga aaagctccgg gtcttaggct ataatcacaa tggggaatgg      300

tgtgaagccc aaaccaaaaa tggccaaggc tgggtcccaa gcaactacat cacgccagtc      360

aacagtctgg agaaacactc ctggtaccat gggcctgtgt cccgcaatgc cgctgagtat      420

ctgctgagca gcgggatcaa tggcagcttc ttggtgcgtg agagtgagag cagtcctggc      480

cagaggtcca tctcgctgag atacgaaggg agggtgtacc attacaggat caacactgct      540

tctgatggca agctctacgt ctcctccgag agccgcttca acaccctggc cgagttggtt      600

catcatcatt caacggtggc cgacgggctc atcaccacgc tccattatcc agccccaaag      660

cgcaacaagc ccactgtcta tggtgtgtcc cccaactacg acaagtggga gatggaacgc      720

acggacatca ccatgaagca caagctgggc gggggccagt acggggaggt gtacgagggc      780

gtgtggaaga aatacagcct gacggtggcc gtgaagacct tgaaggagga caccatggag      840

gtggaagagt tcttgaaaga agctgcagtc atgaaagaga tcaaacaccc taacctggtg      900

cagctccttg gggtctgcac ccgggagccc ccgttctata tcatcactga gttcatgacc      960

tacgggaacc tcctggacta cctgagggag tgcaaccggc aggaggtgaa cgccgtggtg     1020

ctgctgtaca tggccactca gatctcgtca gccatggagt acctggagaa gaaaaacttc     1080

atccacagag atcttgctgc ccgaaactgc ctggtagggg agaaccactt ggtgaaggta     1140

gctgattttg gcctgagcag gttgatgaca ggggacacct acacagccca tgctggagcc     1200

aagttcccca tcaaatggac tgcacccgag agcctggcct acaacaagtt ctccatcaag     1260

tccgacgtct gggcatttgg agtattgctt tgggaaattg ctacctatgg catgtcccct     1320

tacccgggaa ttgacctgtc ccaggtgtat gagctgctag agaaggacta ccgcatggag     1380

cgcccagaag gctgcccaga gaaggtctat gaactcatgc gagcatgttg gcagtggaat     1440

ccctctgacc ggccctcctt tgctgaaatc caccaagcct ttgaaacaat gttccaggaa     1500

tccagtatct cagacgaagt ggaaaaggag ctggggaaac aaggcgtccg tggggctgtg     1560

agtaccttgc tgcaggcccc agagctgccc accaagacga ggacctccag gagagctgca     1620

gagcacagag acaccactga cgtgcctgag atgcctcact ccaagggcca gggagagagc     1680

gatcctctgg accatgagcc tgccgtgtct ccattgctcc ctcgaaaaga gcgaggtccc     1740

ccggagggcg gcctgaatga agatgagcgc cttctcccca aagacaaaaa gaccaacttg     1800

ttcagcgcct tgatcaagaa gaagaagaag acagccccaa cccctcccaa acgcagcagc     1860

tccttccggg agatggacgg ccagccggag cgcagagggg ccggcgagga agagggccga     1920

gacatcagca acggggcact ggctttcacc cccttggaca cagctgaccc agccaagtcc     1980

ccaaagccca gcaatggggc tggggtcccc aatggagccc tccgggagtc cgggggctca     2040

ggcttccggt ctccccacct gtggaagaag tccagcacgc tgaccagcag ccgcctagcc     2100

accggcgagg aggagggcgg tggcagctcc agcaagcgct tcctgcgctc ttgctccgcc     2160

tcctgcgttc cccatggggc caaggacacg gagtggaggt cagtcacgct gcctcgggac     2220

ttgcagtcca cgggaagaca gtttgactcg tccacatttg gagggcacaa aagtgagaag     2280

ccggctctgc ctcggaagag ggcaggggag aacaggtctg accaggtgac ccgaggcaca     2340

gtaacgcctc cccccaggct ggtgaaaaag aatgaggaag ctgctgatga ggtcttcaaa     2400

gacatcatgg agtccagccc gggctccagc ccgcccaacc tgactccaaa acccctccgg     2460

cggcaggtca ccgtggcccc tgcctcgggc ctcccccaca aggaagaagc tggaaagggc     2520

agtgccttag ggacccctgc tgcagctgag ccagtgaccc ccaccagcaa agcaggctca     2580

ggtgcaccag ggggcaccag caagggcccc gccgaggagt ccagagtgag gaggcacaag     2640

cactcctctg agtcgccagg gagggacaag gggaaattgt ccaggctcaa acctgccccg     2700

ccgcccccac cagcagcctc tgcagggaag gctggaggaa agccctcgca gagcccgagc     2760

caggaggcgg ccggggaggc agtcctgggc gcaaagacaa aagccacgag tctggttgat     2820

gctgtgaaca gtgacgctgc caagcccagc cagccgggag agggcctcaa aaagcccgtg     2880

ctcccggcca ctccaaagcc acagtccgcc aagccgtcgg ggacccccat cagcccagcc     2940

cccgttccct ccacgttgcc atcagcatcc tcggccctgg caggggacca gccgtcttcc     3000

accgccttca tccctctcat atcaacccga gtgtctcttc ggaaaacccg ccagcctcca     3060

gagcggatcg ccagcggcgc catcaccaag ggcgtggtcc tggacagcac cgaggcgctg     3120

tgcctcgcca tctctaggaa ctccgagcag atggccagcc acagcgcagt gctggaggcc     3180

ggcaaaaacc tctacacgtt ctgcgtgagc tatgtggatt ccatccagca aatgaggaac     3240

aagtttgcct tccgagaggc catcaacaaa ctggagaata atctccggga gcttcagatc     3300

tgcccggcga cagcaggcag tggtccagcg gccactcagg acttcagcaa gctcctcagt     3360

tcggtgaagg aaatcagtga catagtgcag aggtagcagc agtcaggggt caggtgtcag     3420

gcccgtcgga gctgcctgca gcacatgcgg gctcgcccat acccgtgaca gtggctgaca     3480

agggactagt gagtcagcac cttggcccag gagctctgcg ccaggcagag ctgagggccc     3540

tgtggagtcc agctctacta cctacgtttg caccgcctgc cctcccgcac cttcctcctc     3600

cccgctccgt ctctgtcctc gaattttatc tgtggagttc ctgctccgtg gactgcagtc     3660

ggcatgccag gacccgccag ccccgctccc acctagtgcc ccagactgag ctctccaggc     3720

caggtgggaa cggctgatgt ggactgtctt tttcattttt ttctctctgg agcccctcct     3780

cccccggctg ggcctccttc ttccacttct ccaagaatgg aagcctgaac tgaggccttg     3840

tgtgtcaggc cctctgcctg cactccctgg ccttgcccgt cgtgtgctga agacatgttt     3900

caagaaccgc atttcgggaa gggcatgcac gggcatgcac acggctggtc actctgccct     3960

ctgctgctgc ccggggtggg gtgcactcgc catttcctca cgtgcaggac agctcttgat     4020

ttgggtggaa aacagggtgc taaagccaac cagcctttgg gtcctgggca ggtgggagct     4080

gaaaaggatc gaggcatggg gcatgtcctt tccatctgtc cacatcccca gagcccagct     4140

cttgctctct tgtgacgtgc actgtgaatc ctggcaagaa agcttgagtc tcaagggtgg     4200

caggtcactg tcactgccga catccctccc ccagcagaat ggaggcaggg gacaagggag     4260

gcagtggcta gtggggtgaa cagctggtgc caaatagccc cagactgggc ccaggcaggt     4320

ctgcaagggc ccagagtgaa ccgtcctttc acacatctgg gtgccctgaa agggcccttc     4380

ccctccccca ctcctctaag acaaagtaga ttcttacaag gccctttcct ttggaacaag     4440

acagccttca cttttctgag ttcttgaagc atttcaaagc cctgcctctg tgtagccgcc     4500

ctgagagaga atagagctgc cactgggcac ctgcgcacag gtgggaggaa agggcctggc     4560

cagtcctggt cctggctgca ctcttgaact gggcgaatgt cttatttaat taccgtgagt     4620

gacatagcct catgttctgt gggggtcatc agggagggtt aggaaaacca caaacggagc     4680

ccctgaaagc ctcacgtatt tcacagagca cgcctgccat cttctccccg aggctgcccc     4740

aggccggagc ccagatacgg gggctgtgac tctgggcagg gacccggggt ctcctggacc     4800

ttgacagagc agctaactcc gagagcagtg ggcaggtggc cgcccctgag gcttcacgcc     4860

gggagaagcc accttcccac cccttcatac cgcctcgtgc cagcagcctc gcacaggccc     4920

tagctttacg ctcatcacct aaacttgtac tttatttttc tgatagaaat ggtttcctct     4980

ggatcgtttt atgcggttct tacagcacat cacctctttg cccccgacgg ctgtgacgca     5040

gccggaggga ggcactagtc accgacagcg gccttgaaga cagagcaaag cgcccaccca     5100

ggtcccccga ctgcctgtct ccatgaggta ctggtccctt ccttttgtta acgtgatgtg     5160

ccactatatt ttacacgtat ctcttggtat gcatctttta tagacgctct tttctaagtg     5220

gcgtgtgcat agcgtcctgc cctgccccct cgggggcctg tggtggctcc ccctctgctt     5280

ctcggggtcc agtgcatttt gtttctgtat atgattctct gtggtttttt ttgaatccaa     5340

atctgtcctc tgtagtattt tttaaataaa tcagtgttta catt                      5384


<210>  608
<211>  1130
<212>  PRT
<213>  Homo sapiens

<400>  608

Met Leu Glu Ile Cys Leu Lys Leu Val Gly Cys Lys Ser Lys Lys Gly 
1               5                   10                  15      


Leu Ser Ser Ser Ser Ser Cys Tyr Leu Glu Glu Ala Leu Gln Arg Pro 
            20                  25                  30          


Val Ala Ser Asp Phe Glu Pro Gln Gly Leu Ser Glu Ala Ala Arg Trp 
        35                  40                  45              


Asn Ser Lys Glu Asn Leu Leu Ala Gly Pro Ser Glu Asn Asp Pro Asn 
    50                  55                  60                  


Leu Phe Val Ala Leu Tyr Asp Phe Val Ala Ser Gly Asp Asn Thr Leu 
65                  70                  75                  80  


Ser Ile Thr Lys Gly Glu Lys Leu Arg Val Leu Gly Tyr Asn His Asn 
                85                  90                  95      


Gly Glu Trp Cys Glu Ala Gln Thr Lys Asn Gly Gln Gly Trp Val Pro 
            100                 105                 110         


Ser Asn Tyr Ile Thr Pro Val Asn Ser Leu Glu Lys His Ser Trp Tyr 
        115                 120                 125             


His Gly Pro Val Ser Arg Asn Ala Ala Glu Tyr Leu Leu Ser Ser Gly 
    130                 135                 140                 


Ile Asn Gly Ser Phe Leu Val Arg Glu Ser Glu Ser Ser Pro Gly Gln 
145                 150                 155                 160 


Arg Ser Ile Ser Leu Arg Tyr Glu Gly Arg Val Tyr His Tyr Arg Ile 
                165                 170                 175     


Asn Thr Ala Ser Asp Gly Lys Leu Tyr Val Ser Ser Glu Ser Arg Phe 
            180                 185                 190         


Asn Thr Leu Ala Glu Leu Val His His His Ser Thr Val Ala Asp Gly 
        195                 200                 205             


Leu Ile Thr Thr Leu His Tyr Pro Ala Pro Lys Arg Asn Lys Pro Thr 
    210                 215                 220                 


Val Tyr Gly Val Ser Pro Asn Tyr Asp Lys Trp Glu Met Glu Arg Thr 
225                 230                 235                 240 


Asp Ile Thr Met Lys His Lys Leu Gly Gly Gly Gln Tyr Gly Glu Val 
                245                 250                 255     


Tyr Glu Gly Val Trp Lys Lys Tyr Ser Leu Thr Val Ala Val Lys Thr 
            260                 265                 270         


Leu Lys Glu Asp Thr Met Glu Val Glu Glu Phe Leu Lys Glu Ala Ala 
        275                 280                 285             


Val Met Lys Glu Ile Lys His Pro Asn Leu Val Gln Leu Leu Gly Val 
    290                 295                 300                 


Cys Thr Arg Glu Pro Pro Phe Tyr Ile Ile Ile Glu Phe Met Thr Tyr 
305                 310                 315                 320 


Gly Asn Leu Leu Asp Tyr Leu Arg Glu Cys Asn Arg Gln Glu Val Asn 
                325                 330                 335     


Ala Val Val Leu Leu Tyr Met Ala Thr Gln Ile Ser Ser Ala Met Glu 
            340                 345                 350         


Tyr Leu Glu Lys Lys Asn Phe Ile His Arg Asp Leu Ala Ala Arg Asn 
        355                 360                 365             


Cys Leu Val Gly Glu Asn His Leu Val Lys Val Ala Asp Phe Gly Leu 
    370                 375                 380                 


Ser Arg Leu Met Thr Gly Asp Thr Tyr Thr Ala His Ala Gly Ala Lys 
385                 390                 395                 400 


Phe Pro Ile Lys Trp Thr Ala Pro Glu Ser Leu Ala Tyr Asn Lys Phe 
                405                 410                 415     


Ser Ile Lys Ser Asp Val Trp Ala Phe Gly Val Leu Leu Trp Glu Ile 
            420                 425                 430         


Ala Thr Tyr Gly Met Ser Pro Tyr Pro Gly Ile Asp Leu Ser Gln Val 
        435                 440                 445             


Tyr Glu Leu Leu Glu Lys Asp Tyr Arg Met Glu Arg Pro Glu Gly Cys 
    450                 455                 460                 


Pro Glu Lys Val Tyr Glu Leu Met Arg Ala Cys Trp Gln Trp Asn Pro 
465                 470                 475                 480 


Ser Asp Arg Pro Ser Phe Ala Glu Ile His Gln Ala Phe Glu Thr Met 
                485                 490                 495     


Phe Gln Glu Ser Ser Ile Ser Asp Glu Val Glu Lys Glu Leu Gly Lys 
            500                 505                 510         


Gln Gly Val Arg Gly Ala Val Ser Thr Leu Leu Gln Ala Pro Glu Leu 
        515                 520                 525             


Pro Thr Lys Thr Arg Thr Ser Arg Arg Ala Ala Glu His Arg Asp Thr 
    530                 535                 540                 


Thr Asp Val Pro Glu Met Pro His Ser Lys Gly Gln Gly Glu Ser Asp 
545                 550                 555                 560 


Pro Leu Asp His Glu Pro Ala Val Ser Pro Leu Leu Pro Arg Lys Glu 
                565                 570                 575     


Arg Gly Pro Pro Glu Gly Gly Leu Asn Glu Asp Glu Arg Leu Leu Pro 
            580                 585                 590         


Lys Asp Lys Lys Thr Asn Leu Phe Ser Ala Leu Ile Lys Lys Lys Lys 
        595                 600                 605             


Lys Thr Ala Pro Thr Pro Pro Lys Arg Ser Ser Ser Phe Arg Glu Met 
    610                 615                 620                 


Asp Gly Gln Pro Glu Arg Arg Gly Ala Gly Glu Glu Glu Gly Arg Asp 
625                 630                 635                 640 


Ile Ser Asn Gly Ala Leu Ala Phe Thr Pro Leu Asp Thr Ala Asp Pro 
                645                 650                 655     


Ala Lys Ser Pro Lys Pro Ser Asn Gly Ala Gly Val Pro Asn Gly Ala 
            660                 665                 670         


Leu Arg Glu Ser Gly Gly Ser Gly Phe Arg Ser Pro His Leu Trp Lys 
        675                 680                 685             


Lys Ser Ser Thr Leu Thr Ser Ser Arg Leu Ala Thr Gly Glu Glu Glu 
    690                 695                 700                 


Gly Gly Gly Ser Ser Ser Lys Arg Phe Leu Arg Ser Cys Ser Ala Ser 
705                 710                 715                 720 


Cys Val Pro His Gly Ala Lys Asp Thr Glu Trp Arg Ser Val Thr Leu 
                725                 730                 735     


Pro Arg Asp Leu Gln Ser Thr Gly Arg Gln Phe Asp Ser Ser Thr Phe 
            740                 745                 750         


Gly Gly His Lys Ser Glu Lys Pro Ala Leu Pro Arg Lys Arg Ala Gly 
        755                 760                 765             


Glu Asn Arg Ser Asp Gln Val Thr Arg Gly Thr Val Thr Pro Pro Pro 
    770                 775                 780                 


Arg Leu Val Lys Lys Asn Glu Glu Ala Ala Asp Glu Val Phe Lys Asp 
785                 790                 795                 800 


Ile Met Glu Ser Ser Pro Gly Ser Ser Pro Pro Asn Leu Thr Pro Lys 
                805                 810                 815     


Pro Leu Arg Arg Gln Val Thr Val Ala Pro Ala Ser Gly Leu Pro His 
            820                 825                 830         


Lys Glu Glu Ala Gly Lys Gly Ser Ala Leu Gly Thr Pro Ala Ala Ala 
        835                 840                 845             


Glu Pro Val Thr Pro Thr Ser Lys Ala Gly Ser Gly Ala Pro Gly Gly 
    850                 855                 860                 


Thr Ser Lys Gly Pro Ala Glu Glu Ser Arg Val Arg Arg His Lys His 
865                 870                 875                 880 


Ser Ser Glu Ser Pro Gly Arg Asp Lys Gly Lys Leu Ser Arg Leu Lys 
                885                 890                 895     


Pro Ala Pro Pro Pro Pro Pro Ala Ala Ser Ala Gly Lys Ala Gly Gly 
            900                 905                 910         


Lys Pro Ser Gln Ser Pro Ser Gln Glu Ala Ala Gly Glu Ala Val Leu 
        915                 920                 925             


Gly Ala Lys Thr Lys Ala Thr Ser Leu Val Asp Ala Val Asn Ser Asp 
    930                 935                 940                 


Ala Ala Lys Pro Ser Gln Pro Gly Glu Gly Leu Lys Lys Pro Val Leu 
945                 950                 955                 960 


Pro Ala Thr Pro Lys Pro Gln Ser Ala Lys Pro Ser Gly Thr Pro Ile 
                965                 970                 975     


Ser Pro Ala Pro Val Pro Ser Thr Leu Pro Ser Ala Ser Ser Ala Leu 
            980                 985                 990         


Ala Gly Asp Gln Pro Ser Ser Thr  Ala Phe Ile Pro Leu  Ile Ser Thr 
        995                 1000                 1005             


Arg Val  Ser Leu Arg Lys Thr  Arg Gln Pro Pro Glu  Arg Ile Ala 
    1010                 1015                 1020             


Ser Gly  Ala Ile Thr Lys Gly  Val Val Leu Asp Ser  Thr Glu Ala 
    1025                 1030                 1035             


Leu Cys  Leu Ala Ile Ser Arg  Asn Ser Glu Gln Met  Ala Ser His 
    1040                 1045                 1050             


Ser Ala  Val Leu Glu Ala Gly  Lys Asn Leu Tyr Thr  Phe Cys Val 
    1055                 1060                 1065             


Ser Tyr  Val Asp Ser Ile Gln  Gln Met Arg Asn Lys  Phe Ala Phe 
    1070                 1075                 1080             


Arg Glu  Ala Ile Asn Lys Leu  Glu Asn Asn Leu Arg  Glu Leu Gln 
    1085                 1090                 1095             


Ile Cys  Pro Ala Thr Ala Gly  Ser Gly Pro Ala Ala  Thr Gln Asp 
    1100                 1105                 1110             


Phe Ser  Lys Leu Leu Ser Ser  Val Lys Glu Ile Ser  Asp Ile Val 
    1115                 1120                 1125             


Gln Arg  
    1130 


<210>  609
<211>  1130
<212>  PRT
<213>  Homo sapiens

<400>  609

Met Leu Glu Ile Cys Leu Lys Leu Val Gly Cys Lys Ser Lys Lys Gly 
1               5                   10                  15      


Leu Ser Ser Ser Ser Ser Cys Tyr Leu Glu Glu Ala Leu Gln Arg Pro 
            20                  25                  30          


Val Ala Ser Asp Phe Glu Pro Gln Gly Leu Ser Glu Ala Ala Arg Trp 
        35                  40                  45              


Asn Ser Lys Glu Asn Leu Leu Ala Gly Pro Ser Glu Asn Asp Pro Asn 
    50                  55                  60                  


Leu Phe Val Ala Leu Tyr Asp Phe Val Ala Ser Gly Asp Asn Thr Leu 
65                  70                  75                  80  


Ser Ile Thr Lys Gly Glu Lys Leu Arg Val Leu Gly Tyr Asn His Asn 
                85                  90                  95      


Gly Glu Trp Cys Glu Ala Gln Thr Lys Asn Gly Gln Gly Trp Val Pro 
            100                 105                 110         


Ser Asn Tyr Ile Thr Pro Val Asn Ser Leu Glu Lys His Ser Trp Tyr 
        115                 120                 125             


His Gly Pro Val Ser Arg Asn Ala Ala Glu Tyr Leu Leu Ser Ser Gly 
    130                 135                 140                 


Ile Asn Gly Ser Phe Leu Val Arg Glu Ser Glu Ser Ser Pro Gly Gln 
145                 150                 155                 160 


Arg Ser Ile Ser Leu Arg Tyr Glu Gly Arg Val Tyr His Tyr Arg Ile 
                165                 170                 175     


Asn Thr Ala Ser Asp Gly Lys Leu Tyr Val Ser Ser Glu Ser Arg Phe 
            180                 185                 190         


Asn Thr Leu Ala Glu Leu Val His His His Ser Thr Val Ala Asp Gly 
        195                 200                 205             


Leu Ile Thr Thr Leu His Tyr Pro Ala Pro Lys Arg Asn Lys Pro Thr 
    210                 215                 220                 


Val Tyr Gly Val Ser Pro Asn Tyr Asp Lys Trp Glu Met Glu Arg Thr 
225                 230                 235                 240 


Asp Ile Thr Met Lys His Lys Leu Gly Gly Gly Gln Tyr Gly Glu Val 
                245                 250                 255     


Tyr Glu Gly Val Trp Lys Lys Tyr Ser Leu Thr Val Ala Val Lys Thr 
            260                 265                 270         


Leu Lys Glu Asp Thr Met Glu Val Glu Glu Phe Leu Lys Glu Ala Ala 
        275                 280                 285             


Val Met Lys Glu Ile Lys His Pro Asn Leu Val Gln Leu Leu Gly Val 
    290                 295                 300                 


Cys Thr Arg Glu Pro Pro Phe Tyr Ile Ile Ile Glu Phe Met Thr Tyr 
305                 310                 315                 320 


Gly Asn Leu Leu Asp Tyr Leu Arg Glu Cys Asn Arg Gln Glu Val Asn 
                325                 330                 335     


Ala Val Val Leu Leu Tyr Met Ala Thr Gln Ile Ser Ser Ala Met Glu 
            340                 345                 350         


Tyr Leu Glu Lys Lys Asn Phe Ile His Arg Asp Leu Ala Ala Arg Asn 
        355                 360                 365             


Cys Leu Val Gly Glu Asn His Leu Val Lys Val Ala Asp Phe Gly Leu 
    370                 375                 380                 


Ser Arg Leu Met Thr Gly Asp Thr Tyr Thr Ala His Ala Gly Ala Lys 
385                 390                 395                 400 


Phe Pro Ile Lys Trp Thr Ala Pro Glu Ser Leu Ala Tyr Asn Lys Phe 
                405                 410                 415     


Ser Ile Lys Ser Asp Val Trp Ala Phe Gly Val Leu Leu Trp Glu Ile 
            420                 425                 430         


Ala Thr Tyr Gly Met Ser Pro Tyr Pro Gly Ile Asp Leu Ser Gln Val 
        435                 440                 445             


Tyr Glu Leu Leu Glu Lys Asp Tyr Arg Met Glu Arg Pro Glu Gly Cys 
    450                 455                 460                 


Pro Glu Lys Val Tyr Glu Leu Met Arg Ala Cys Trp Gln Trp Asn Pro 
465                 470                 475                 480 


Ser Asp Arg Pro Ser Phe Ala Glu Ile His Gln Ala Phe Glu Thr Met 
                485                 490                 495     


Phe Gln Glu Ser Ser Ile Ser Asp Glu Val Glu Lys Glu Leu Gly Lys 
            500                 505                 510         


Gln Gly Val Arg Gly Ala Val Ser Thr Leu Leu Gln Ala Pro Glu Leu 
        515                 520                 525             


Pro Thr Lys Thr Arg Thr Ser Arg Arg Ala Ala Glu His Arg Asp Thr 
    530                 535                 540                 


Thr Asp Val Pro Glu Met Pro His Ser Lys Gly Gln Gly Glu Ser Asp 
545                 550                 555                 560 


Pro Leu Asp His Glu Pro Ala Val Ser Pro Leu Leu Pro Arg Lys Glu 
                565                 570                 575     


Arg Gly Pro Pro Glu Gly Gly Leu Asn Glu Asp Glu Arg Leu Leu Pro 
            580                 585                 590         


Lys Asp Lys Lys Thr Asn Leu Phe Ser Ala Leu Ile Lys Lys Lys Lys 
        595                 600                 605             


Lys Thr Ala Pro Thr Pro Pro Lys Arg Ser Ser Ser Phe Arg Glu Met 
    610                 615                 620                 


Asp Gly Gln Pro Glu Arg Arg Gly Ala Gly Glu Glu Glu Gly Arg Asp 
625                 630                 635                 640 


Ile Ser Asn Gly Ala Leu Ala Phe Thr Pro Leu Asp Thr Ala Asp Pro 
                645                 650                 655     


Ala Lys Ser Pro Lys Pro Ser Asn Gly Ala Gly Val Pro Asn Gly Ala 
            660                 665                 670         


Leu Arg Glu Ser Gly Gly Ser Gly Phe Arg Ser Pro His Leu Trp Lys 
        675                 680                 685             


Lys Ser Ser Thr Leu Thr Ser Ser Arg Leu Ala Thr Gly Glu Glu Glu 
    690                 695                 700                 


Gly Gly Gly Ser Ser Ser Lys Arg Phe Leu Arg Ser Cys Ser Ala Ser 
705                 710                 715                 720 


Cys Val Pro His Gly Ala Lys Asp Thr Glu Trp Arg Ser Val Thr Leu 
                725                 730                 735     


Pro Arg Asp Leu Gln Ser Thr Gly Arg Gln Phe Asp Ser Ser Thr Phe 
            740                 745                 750         


Gly Gly His Lys Ser Glu Lys Pro Ala Leu Pro Arg Lys Arg Ala Gly 
        755                 760                 765             


Glu Asn Arg Ser Asp Gln Val Thr Arg Gly Thr Val Thr Pro Pro Pro 
    770                 775                 780                 


Arg Leu Val Lys Lys Asn Glu Glu Ala Ala Asp Glu Val Phe Lys Asp 
785                 790                 795                 800 


Ile Met Glu Ser Ser Pro Gly Ser Ser Pro Pro Asn Leu Thr Pro Lys 
                805                 810                 815     


Pro Leu Arg Arg Gln Val Thr Val Ala Pro Ala Ser Gly Leu Pro His 
            820                 825                 830         


Lys Glu Glu Ala Gly Lys Gly Ser Ala Leu Gly Thr Pro Ala Ala Ala 
        835                 840                 845             


Glu Pro Val Thr Pro Thr Ser Lys Ala Gly Ser Gly Ala Pro Gly Gly 
    850                 855                 860                 


Thr Ser Lys Gly Pro Ala Glu Glu Ser Arg Val Arg Arg His Lys His 
865                 870                 875                 880 


Ser Ser Glu Ser Pro Gly Arg Asp Lys Gly Lys Leu Ser Arg Leu Lys 
                885                 890                 895     


Pro Ala Pro Pro Pro Pro Pro Ala Ala Ser Ala Gly Lys Ala Gly Gly 
            900                 905                 910         


Lys Pro Ser Gln Ser Pro Ser Gln Glu Ala Ala Gly Glu Ala Val Leu 
        915                 920                 925             


Gly Ala Lys Thr Lys Ala Thr Ser Leu Val Asp Ala Val Asn Ser Asp 
    930                 935                 940                 


Ala Ala Lys Pro Ser Gln Pro Gly Glu Gly Leu Lys Lys Pro Val Leu 
945                 950                 955                 960 


Pro Ala Thr Pro Lys Pro Gln Ser Ala Lys Pro Ser Gly Thr Pro Ile 
                965                 970                 975     


Ser Pro Ala Pro Val Pro Ser Thr Leu Pro Ser Ala Ser Ser Ala Leu 
            980                 985                 990         


Ala Gly Asp Gln Pro Ser Ser Thr  Ala Phe Ile Pro Leu  Ile Ser Thr 
        995                 1000                 1005             


Arg Val  Ser Leu Arg Lys Thr  Arg Gln Pro Pro Glu  Arg Ile Ala 
    1010                 1015                 1020             


Ser Gly  Ala Ile Thr Lys Gly  Val Val Leu Asp Ser  Thr Glu Ala 
    1025                 1030                 1035             


Leu Cys  Leu Ala Ile Ser Arg  Asn Ser Glu Gln Met  Ala Ser His 
    1040                 1045                 1050             


Ser Ala  Val Leu Glu Ala Gly  Lys Asn Leu Tyr Thr  Phe Cys Val 
    1055                 1060                 1065             


Ser Tyr  Val Asp Ser Ile Gln  Gln Met Arg Asn Lys  Phe Ala Phe 
    1070                 1075                 1080             


Arg Glu  Ala Ile Asn Lys Leu  Glu Asn Asn Leu Arg  Glu Leu Gln 
    1085                 1090                 1095             


Ile Cys  Pro Ala Thr Ala Gly  Ser Gly Pro Ala Ala  Thr Gln Asp 
    1100                 1105                 1110             


Phe Ser  Lys Leu Leu Ser Ser  Val Lys Glu Ile Ser  Asp Ile Val 
    1115                 1120                 1125             


Gln Arg  
    1130 


<210>  610
<211>  3543
<212>  DNA
<213>  Homo sapiens

<400>  610
agaggtatgg tccttgggac agttctcctt ccacctaata cttatggcag agatcaggac       60

acttcacttt gctgcctgtg cactgaggcc tcagaatctg ctctacccga cttaacagaa      120

gctttgcatc gtccctatgg ttgtgatgtt gaaccccagg cactaaatga ggctatcagg      180

tggagctcca aggagaactt gctcggagcc actgagagtg accctaatct cttcgttgca      240

ctttatgatt ttgtagcaag tggtgataac acactcagca tcactaaagg tgaaaagcta      300

cgagtccttg gttacaacca gaatggtgag tggagtgaag ttcgctctaa gaatgggcag      360

ggctgggtgc caagcaacta catcacccca gtgaacagcc tggaaaaaca ctcctggtac      420

catggacctg tgtcacgcag tgcagctgag tatctgctca gcagtctaat caatggcagc      480

ttcctggtgc gagaaagtga gagtagccct gggcagctgt ccatctcgct caggtacgag      540

ggacgtgtgt atcactacag gatcaatacc actgcagatg gcaaggtgta tgtgactgct      600

gagagccgct tcagcacctt ggcagagctt gtacaccatc actccacagt ggctgatggg      660

ctggtgacaa cattacacta cccagcaccc aagtgtaata agcctacagt ctatggtgtg      720

tcccccatcc acgacaaatg ggaaatggag cgaacagata ttaccatgaa gcacaaactt      780

gggggcggtc agtatggaga ggtttacgtt ggcgtctgga agaaatacag ccttacagtt      840

gctgtgaaaa cattgaagga agataccatg gaggtagaag aattcctgaa agaagctgca      900

gtaatgaagg aaatcaagca tcctaatctg gtacaacttt taggtgtgtg tactttggag      960

ccaccatttt acattgtgac tgaatacatg ccatacggga atttgctgga ttacctccga     1020

gaatgcaacc gagaagaggt gactgcagtt gtgctgctct acatggccac tcagatttct     1080

tctgcaatgg agtacttaga gaagaagaat ttcatccata gagatcttgc agctcgtaac     1140

tgcctagtgg gagaaaacca tgtggtaaaa gtggctgact ttggcttaag tagattgatg     1200

actggagaca cttatactgc tcatgctgga gccaaatttc ctattaagtg gacagcacca     1260

gagagtcttg cctacaatac cttctcaatt aaatctgacg tctgggcttt tggggtattg     1320

ttgtgggaaa ttgctaccta tggaatgtca ccatatccag gtattgacct gtctcaggtc     1380

tatgacctac tagaaaaagg atatcgaatg gaacagcctg agggatgccc ccctaaggtt     1440

tatgaactta tgagagcatg ctggaagtgg agccctgccg ataggccctc ttttgctgaa     1500

acacaccaag cttttgaaac catgttccat gactccagca tttctgaaga ggtagctgag     1560

gagcttggga gagccgcctc ctcgtcatct gttgttccat acctgccccg gctacctata     1620

cttccttcca agactcggac actgaagaaa caggtggaga acaaggagaa cattgaaggg     1680

gcacaagatg ccacagaaaa ttctgcttcc agtttagcac cagggttcat cagaggtgca     1740

caggcctcta gtggatcccc agcactgcct cgaaagcaaa gagacaagtc acccagcagc     1800

ctcttggaag atgccaaaga gacatgcttc accagggata ggaagggggg cttcttcagc     1860

tccttcatga agaagagaaa tgctcctaca ccccccaaac gcagcagctc cttccgagaa     1920

atggagaatc agccccataa gaaatacgaa ctcacgggta acttctcatc tgttgcttct     1980

ctacagcatg ctgatgggtt ctctttcact cctgcccagc aagaggcgaa tctggtgcca     2040

cccaagtgct atggggggag ctttgcacag aggaacctct gtaatgacga cggtggtggg     2100

ggtgggggca gtggcactgc tgggggtggg tggtctggca tcacaggctt ctttacacca     2160

cgcttaatca aaaagacact gggcttacga gcaggtaaac ccacagccag tgatgacact     2220

tccaagcctt ttccaaggtc aaactctaca tcttccatgt cctcagggct tccagagcag     2280

gataggatgg caatgaccct tcccaggaac tgccagaggt ccaaactcca gctggaaagg     2340

acagtgtcca cctcttctca gccagaagag aatgtggaca gggccaatga catgcttcca     2400

aaaaaatcag aggaaagtgc tgctccaagc agggagagac caaaagccaa gttattgccc     2460

agaggagcca cagctcttcc tctcagaaca ccctctgggg atctagccat tacagagaag     2520

gaccctccag gggtgggagt ggctggagtg gcagctgccc ccaagggtaa agagaagaat     2580

ggtggggcac gacttgggat ggctggagtt ccagaggatg gagagcagcc gggctggcct     2640

tctccagcca aggctgcccc cgtcctccca accactcaca accacaaagt gccagtcctt     2700

atctcaccca ctctgaaaca cactccagct gacgtgcagc tcattggcac agactctcag     2760

gggaataaat tcaagctctt atctgagcat caggtcacat cctctggaga caaggaccga     2820

ccccgacggg taaaaccaaa gtgtgcccca cccccaccac cagtgatgag actactgcag     2880

catccgtcca tctgctcaga ccctacagaa gagccaactg ccctaactgc aggacagtcc     2940

acatcagaaa cacaggaagg aggaaagaag gcagctctgg gcgcagtgcc catcagtggg     3000

aaagctggga ggccagtgat gcctccacct caagtgcctc tgcccacatc ttccatctcg     3060

ccagccaaaa tggccaatgg cacagcaggt actaaagtgg ctctgagaaa aaccaaacag     3120

gccgctgaga aaatctcagc agacaaaatc agcaaagagg ccctgctgga atgtgctgac     3180

ctactgtcca gtgcactcac ggaacctgtg cccaacagcc agctggtaga cactggacac     3240

cagctgcttg actactgctc aggctatgtg gactgcatcc ctcaaactcg caacaaattt     3300

gccttccgag aggctgtgag caaactggaa ctcagcctgc aggagctaca ggtttcttca     3360

gcagctgctg gtgtgcccgg gacaaaccct gtccttaata acttattgtc atgtgtacag     3420

gaaatcagtg atgtggtgca gaggtagcca ctgttagcct ggtgggaaaa tgcacacatt     3480

tctgagggga gagggaaaag gacttgtttt cctgtgttct tgttttcaga aaatgaaaga     3540

ctc                                                                   3543


<210>  611
<211>  1182
<212>  PRT
<213>  Homo sapiens

<400>  611

Met Gly Gln Gln Val Gly Arg Val Gly Glu Ala Pro Gly Leu Gln Gln 
1               5                   10                  15      


Pro Gln Pro Arg Gly Ile Arg Gly Ser Ser Ala Ala Arg Pro Ser Gly 
            20                  25                  30          


Arg Arg Arg Asp Pro Ala Gly Arg Thr Thr Glu Thr Gly Phe Asn Ile 
        35                  40                  45              


Phe Thr Gln His Asp His Phe Ala Ser Cys Val Glu Asp Gly Phe Glu 
    50                  55                  60                  


Gly Asp Lys Thr Gly Gly Ser Ser Pro Glu Ala Leu His Arg Pro Tyr 
65                  70                  75                  80  


Gly Cys Asp Val Glu Pro Gln Ala Leu Asn Glu Ala Ile Arg Trp Ser 
                85                  90                  95      


Ser Lys Glu Asn Leu Leu Gly Ala Thr Glu Ser Asp Pro Asn Leu Phe 
            100                 105                 110         


Val Ala Leu Tyr Asp Phe Val Ala Ser Gly Asp Asn Thr Leu Ser Ile 
        115                 120                 125             


Thr Lys Gly Glu Lys Leu Arg Val Leu Gly Tyr Asn Gln Asn Gly Glu 
    130                 135                 140                 


Trp Ser Glu Val Arg Ser Lys Asn Gly Gln Gly Trp Val Pro Ser Asn 
145                 150                 155                 160 


Tyr Ile Thr Pro Val Asn Ser Leu Glu Lys His Ser Trp Tyr His Gly 
                165                 170                 175     


Pro Val Ser Arg Ser Ala Ala Glu Tyr Leu Leu Ser Ser Leu Ile Asn 
            180                 185                 190         


Gly Ser Phe Leu Val Arg Glu Ser Glu Ser Ser Pro Gly Gln Leu Ser 
        195                 200                 205             


Ile Ser Leu Arg Tyr Glu Gly Arg Val Tyr His Tyr Arg Ile Asn Thr 
    210                 215                 220                 


Thr Ala Asp Gly Lys Val Tyr Val Thr Ala Glu Ser Arg Phe Ser Thr 
225                 230                 235                 240 


Leu Ala Glu Leu Val His His His Ser Thr Val Ala Asp Gly Leu Val 
                245                 250                 255     


Thr Thr Leu His Tyr Pro Ala Pro Lys Cys Asn Lys Pro Thr Val Tyr 
            260                 265                 270         


Gly Val Ser Pro Ile His Asp Lys Trp Glu Met Glu Arg Thr Asp Ile 
        275                 280                 285             


Thr Met Lys His Lys Leu Gly Gly Gly Gln Tyr Gly Glu Val Tyr Val 
    290                 295                 300                 


Gly Val Trp Lys Lys Tyr Ser Leu Thr Val Ala Val Lys Thr Leu Lys 
305                 310                 315                 320 


Glu Asp Thr Met Glu Val Glu Glu Phe Leu Lys Glu Ala Ala Val Met 
                325                 330                 335     


Lys Glu Ile Lys His Pro Asn Leu Val Gln Leu Leu Gly Val Cys Thr 
            340                 345                 350         


Leu Glu Pro Pro Phe Tyr Ile Val Thr Glu Tyr Met Pro Tyr Gly Asn 
        355                 360                 365             


Leu Leu Asp Tyr Leu Arg Glu Cys Asn Arg Glu Glu Val Thr Ala Val 
    370                 375                 380                 


Val Leu Leu Tyr Met Ala Thr Gln Ile Ser Ser Ala Met Glu Tyr Leu 
385                 390                 395                 400 


Glu Lys Lys Asn Phe Ile His Arg Asp Leu Ala Ala Arg Asn Cys Leu 
                405                 410                 415     


Val Gly Glu Asn His Val Val Lys Val Ala Asp Phe Gly Leu Ser Arg 
            420                 425                 430         


Leu Met Thr Gly Asp Thr Tyr Thr Ala His Ala Gly Ala Lys Phe Pro 
        435                 440                 445             


Ile Lys Trp Thr Ala Pro Glu Ser Leu Ala Tyr Asn Thr Phe Ser Ile 
    450                 455                 460                 


Lys Ser Asp Val Trp Ala Phe Gly Val Leu Leu Trp Glu Ile Ala Thr 
465                 470                 475                 480 


Tyr Gly Met Ser Pro Tyr Pro Gly Ile Asp Leu Ser Gln Val Tyr Asp 
                485                 490                 495     


Leu Leu Glu Lys Gly Tyr Arg Met Glu Gln Pro Glu Gly Cys Pro Pro 
            500                 505                 510         


Lys Val Tyr Glu Leu Met Arg Ala Cys Trp Lys Trp Ser Pro Ala Asp 
        515                 520                 525             


Arg Pro Ser Phe Ala Glu Thr His Gln Ala Phe Glu Thr Met Phe His 
    530                 535                 540                 


Asp Ser Ser Ile Ser Glu Glu Val Ala Glu Glu Leu Gly Arg Ala Ala 
545                 550                 555                 560 


Ser Ser Ser Ser Val Val Pro Tyr Leu Pro Arg Leu Pro Ile Leu Pro 
                565                 570                 575     


Ser Lys Thr Arg Thr Leu Lys Lys Gln Val Glu Asn Lys Glu Asn Ile 
            580                 585                 590         


Glu Gly Ala Gln Asp Ala Thr Glu Asn Ser Ala Ser Ser Leu Ala Pro 
        595                 600                 605             


Gly Phe Ile Arg Gly Ala Gln Ala Ser Ser Gly Ser Pro Ala Leu Pro 
    610                 615                 620                 


Arg Lys Gln Arg Asp Lys Ser Pro Ser Ser Leu Leu Glu Asp Ala Lys 
625                 630                 635                 640 


Glu Thr Cys Phe Thr Arg Asp Arg Lys Gly Gly Phe Phe Ser Ser Phe 
                645                 650                 655     


Met Lys Lys Arg Asn Ala Pro Thr Pro Pro Lys Arg Ser Ser Ser Phe 
            660                 665                 670         


Arg Glu Met Glu Asn Gln Pro His Lys Lys Tyr Glu Leu Thr Gly Asn 
        675                 680                 685             


Phe Ser Ser Val Ala Ser Leu Gln His Ala Asp Gly Phe Ser Phe Thr 
    690                 695                 700                 


Pro Ala Gln Gln Glu Ala Asn Leu Val Pro Pro Lys Cys Tyr Gly Gly 
705                 710                 715                 720 


Ser Phe Ala Gln Arg Asn Leu Cys Asn Asp Asp Gly Gly Gly Gly Gly 
                725                 730                 735     


Gly Ser Gly Thr Ala Gly Gly Gly Trp Ser Gly Ile Thr Gly Phe Phe 
            740                 745                 750         


Thr Pro Arg Leu Ile Lys Lys Thr Leu Gly Leu Arg Ala Gly Lys Pro 
        755                 760                 765             


Thr Ala Ser Asp Asp Thr Ser Lys Pro Phe Pro Arg Ser Asn Ser Thr 
    770                 775                 780                 


Ser Ser Met Ser Ser Gly Leu Pro Glu Gln Asp Arg Met Ala Met Thr 
785                 790                 795                 800 


Leu Pro Arg Asn Cys Gln Arg Ser Lys Leu Gln Leu Glu Arg Thr Val 
                805                 810                 815     


Ser Thr Ser Ser Gln Pro Glu Glu Asn Val Asp Arg Ala Asn Asp Met 
            820                 825                 830         


Leu Pro Lys Lys Ser Glu Glu Ser Ala Ala Pro Ser Arg Glu Arg Pro 
        835                 840                 845             


Lys Ala Lys Leu Leu Pro Arg Gly Ala Thr Ala Leu Pro Leu Arg Thr 
    850                 855                 860                 


Pro Ser Gly Asp Leu Ala Ile Thr Glu Lys Asp Pro Pro Gly Val Gly 
865                 870                 875                 880 


Val Ala Gly Val Ala Ala Ala Pro Lys Gly Lys Glu Lys Asn Gly Gly 
                885                 890                 895     


Ala Arg Leu Gly Met Ala Gly Val Pro Glu Asp Gly Glu Gln Pro Gly 
            900                 905                 910         


Trp Pro Ser Pro Ala Lys Ala Ala Pro Val Leu Pro Thr Thr His Asn 
        915                 920                 925             


His Lys Val Pro Val Leu Ile Ser Pro Thr Leu Lys His Thr Pro Ala 
    930                 935                 940                 


Asp Val Gln Leu Ile Gly Thr Asp Ser Gln Gly Asn Lys Phe Lys Leu 
945                 950                 955                 960 


Leu Ser Glu His Gln Val Thr Ser Ser Gly Asp Lys Asp Arg Pro Arg 
                965                 970                 975     


Arg Val Lys Pro Lys Cys Ala Pro Pro Pro Pro Pro Val Met Arg Leu 
            980                 985                 990         


Leu Gln His Pro Ser Ile Cys Ser  Asp Pro Thr Glu Glu  Pro Thr Ala 
        995                 1000                 1005             


Leu Thr  Ala Gly Gln Ser Thr  Ser Glu Thr Gln Glu  Gly Gly Lys 
    1010                 1015                 1020             


Lys Ala  Ala Leu Gly Ala Val  Pro Ile Ser Gly Lys  Ala Gly Arg 
    1025                 1030                 1035             


Pro Val  Met Pro Pro Pro Gln  Val Pro Leu Pro Thr  Ser Ser Ile 
    1040                 1045                 1050             


Ser Pro  Ala Lys Met Ala Asn  Gly Thr Ala Gly Thr  Lys Val Ala 
    1055                 1060                 1065             


Leu Arg  Lys Thr Lys Gln Ala  Ala Glu Lys Ile Ser  Ala Asp Lys 
    1070                 1075                 1080             


Ile Ser  Lys Glu Ala Leu Leu  Glu Cys Ala Asp Leu  Leu Ser Ser 
    1085                 1090                 1095             


Ala Leu  Thr Glu Pro Val Pro  Asn Ser Gln Leu Val  Asp Thr Gly 
    1100                 1105                 1110             


His Gln  Leu Leu Asp Tyr Cys  Ser Gly Tyr Val Asp  Cys Ile Pro 
    1115                 1120                 1125             


Gln Thr  Arg Asn Lys Phe Ala  Phe Arg Glu Ala Val  Ser Lys Leu 
    1130                 1135                 1140             


Glu Leu  Ser Leu Gln Glu Leu  Gln Val Ser Ser Ala  Ala Ala Gly 
    1145                 1150                 1155             


Val Pro  Gly Thr Asn Pro Val  Leu Asn Asn Leu Leu  Ser Cys Val 
    1160                 1165                 1170             


Gln Glu  Ile Ser Asp Val Val  Gln Arg 
    1175                 1180         


<210>  612
<211>  1130
<212>  PRT
<213>  Homo sapiens

<400>  612

Met Leu Glu Ile Cys Leu Lys Leu Val Gly Cys Lys Ser Lys Lys Gly 
1               5                   10                  15      


Leu Ser Ser Ser Ser Ser Cys Tyr Leu Glu Glu Ala Leu Gln Arg Pro 
            20                  25                  30          


Val Ala Ser Asp Phe Glu Pro Gln Gly Leu Ser Glu Ala Ala Arg Trp 
        35                  40                  45              


Asn Ser Lys Glu Asn Leu Leu Ala Gly Pro Ser Glu Asn Asp Pro Asn 
    50                  55                  60                  


Leu Phe Val Ala Leu Tyr Asp Phe Val Ala Ser Gly Asp Asn Thr Leu 
65                  70                  75                  80  


Ser Ile Thr Lys Gly Glu Lys Leu Arg Val Leu Gly Tyr Asn His Asn 
                85                  90                  95      


Gly Glu Trp Cys Glu Ala Gln Thr Lys Asn Gly Gln Gly Trp Val Pro 
            100                 105                 110         


Ser Asn Tyr Ile Thr Pro Val Asn Ser Leu Glu Lys His Ser Trp Tyr 
        115                 120                 125             


His Gly Pro Val Ser Arg Asn Ala Ala Glu Tyr Leu Leu Ser Ser Gly 
    130                 135                 140                 


Ile Asn Gly Ser Phe Leu Val Arg Glu Ser Glu Ser Ser Pro Gly Gln 
145                 150                 155                 160 


Arg Ser Ile Ser Leu Arg Tyr Glu Gly Arg Val Tyr His Tyr Arg Ile 
                165                 170                 175     


Asn Thr Ala Ser Asp Gly Lys Leu Tyr Val Ser Ser Glu Ser Arg Phe 
            180                 185                 190         


Asn Thr Leu Ala Glu Leu Val His His His Ser Thr Val Ala Asp Gly 
        195                 200                 205             


Leu Ile Thr Thr Leu His Tyr Pro Ala Pro Lys Arg Asn Lys Pro Thr 
    210                 215                 220                 


Val Tyr Gly Val Ser Pro Asn Tyr Asp Lys Trp Glu Met Glu Arg Thr 
225                 230                 235                 240 


Asp Ile Thr Met Lys His Lys Leu Gly Gly Gly Gln Phe Gly Glu Val 
                245                 250                 255     


Tyr Glu Gly Val Trp Lys Lys Tyr Ser Leu Thr Val Ala Val Lys Thr 
            260                 265                 270         


Leu Lys Glu Asp Thr Met Glu Val Glu Glu Phe Leu Lys Glu Ala Ala 
        275                 280                 285             


Val Met Lys Glu Ile Lys His Pro Asn Leu Val Gln Leu Leu Gly Val 
    290                 295                 300                 


Cys Thr Arg Glu Pro Pro Phe Tyr Ile Ile Thr Glu Phe Met Thr Tyr 
305                 310                 315                 320 


Gly Asn Leu Leu Asp Tyr Leu Arg Glu Cys Asn Arg Gln Glu Val Asn 
                325                 330                 335     


Ala Val Val Leu Leu Tyr Met Ala Thr Gln Ile Ser Ser Ala Met Glu 
            340                 345                 350         


Tyr Leu Glu Lys Lys Asn Phe Ile His Arg Asp Leu Ala Ala Arg Asn 
        355                 360                 365             


Cys Leu Val Gly Glu Asn His Leu Val Lys Val Ala Asp Phe Gly Leu 
    370                 375                 380                 


Ser Arg Leu Met Thr Gly Asp Thr Tyr Thr Ala His Ala Gly Ala Lys 
385                 390                 395                 400 


Phe Pro Ile Lys Trp Thr Ala Pro Glu Ser Leu Ala Tyr Asn Lys Phe 
                405                 410                 415     


Ser Ile Lys Ser Asp Val Trp Ala Phe Gly Val Leu Leu Trp Glu Ile 
            420                 425                 430         


Ala Thr Tyr Gly Met Ser Pro Tyr Pro Gly Ile Asp Leu Ser Gln Val 
        435                 440                 445             


Tyr Glu Leu Leu Glu Lys Asp Tyr Arg Met Glu Arg Pro Glu Gly Cys 
    450                 455                 460                 


Pro Glu Lys Val Tyr Glu Leu Met Arg Ala Cys Trp Gln Trp Asn Pro 
465                 470                 475                 480 


Ser Asp Arg Pro Ser Phe Ala Glu Ile His Gln Ala Phe Glu Thr Met 
                485                 490                 495     


Phe Gln Glu Ser Ser Ile Ser Asp Glu Val Glu Lys Glu Leu Gly Lys 
            500                 505                 510         


Gln Gly Val Arg Gly Ala Val Ser Thr Leu Leu Gln Ala Pro Glu Leu 
        515                 520                 525             


Pro Thr Lys Thr Arg Thr Ser Arg Arg Ala Ala Glu His Arg Asp Thr 
    530                 535                 540                 


Thr Asp Val Pro Glu Met Pro His Ser Lys Gly Gln Gly Glu Ser Asp 
545                 550                 555                 560 


Pro Leu Asp His Glu Pro Ala Val Ser Pro Leu Leu Pro Arg Lys Glu 
                565                 570                 575     


Arg Gly Pro Pro Glu Gly Gly Leu Asn Glu Asp Glu Arg Leu Leu Pro 
            580                 585                 590         


Lys Asp Lys Lys Thr Asn Leu Phe Ser Ala Leu Ile Lys Lys Lys Lys 
        595                 600                 605             


Lys Thr Ala Pro Thr Pro Pro Lys Arg Ser Ser Ser Phe Arg Glu Met 
    610                 615                 620                 


Asp Gly Gln Pro Glu Arg Arg Gly Ala Gly Glu Glu Glu Gly Arg Asp 
625                 630                 635                 640 


Ile Ser Asn Gly Ala Leu Ala Phe Thr Pro Leu Asp Thr Ala Asp Pro 
                645                 650                 655     


Ala Lys Ser Pro Lys Pro Ser Asn Gly Ala Gly Val Pro Asn Gly Ala 
            660                 665                 670         


Leu Arg Glu Ser Gly Gly Ser Gly Phe Arg Ser Pro His Leu Trp Lys 
        675                 680                 685             


Lys Ser Ser Thr Leu Thr Ser Ser Arg Leu Ala Thr Gly Glu Glu Glu 
    690                 695                 700                 


Gly Gly Gly Ser Ser Ser Lys Arg Phe Leu Arg Ser Cys Ser Ala Ser 
705                 710                 715                 720 


Cys Val Pro His Gly Ala Lys Asp Thr Glu Trp Arg Ser Val Thr Leu 
                725                 730                 735     


Pro Arg Asp Leu Gln Ser Thr Gly Arg Gln Phe Asp Ser Ser Thr Phe 
            740                 745                 750         


Gly Gly His Lys Ser Glu Lys Pro Ala Leu Pro Arg Lys Arg Ala Gly 
        755                 760                 765             


Glu Asn Arg Ser Asp Gln Val Thr Arg Gly Thr Val Thr Pro Pro Pro 
    770                 775                 780                 


Arg Leu Val Lys Lys Asn Glu Glu Ala Ala Asp Glu Val Phe Lys Asp 
785                 790                 795                 800 


Ile Met Glu Ser Ser Pro Gly Ser Ser Pro Pro Asn Leu Thr Pro Lys 
                805                 810                 815     


Pro Leu Arg Arg Gln Val Thr Val Ala Pro Ala Ser Gly Leu Pro His 
            820                 825                 830         


Lys Glu Glu Ala Gly Lys Gly Ser Ala Leu Gly Thr Pro Ala Ala Ala 
        835                 840                 845             


Glu Pro Val Thr Pro Thr Ser Lys Ala Gly Ser Gly Ala Pro Gly Gly 
    850                 855                 860                 


Thr Ser Lys Gly Pro Ala Glu Glu Ser Arg Val Arg Arg His Lys His 
865                 870                 875                 880 


Ser Ser Glu Ser Pro Gly Arg Asp Lys Gly Lys Leu Ser Arg Leu Lys 
                885                 890                 895     


Pro Ala Pro Pro Pro Pro Pro Ala Ala Ser Ala Gly Lys Ala Gly Gly 
            900                 905                 910         


Lys Pro Ser Gln Ser Pro Ser Gln Glu Ala Ala Gly Glu Ala Val Leu 
        915                 920                 925             


Gly Ala Lys Thr Lys Ala Thr Ser Leu Val Asp Ala Val Asn Ser Asp 
    930                 935                 940                 


Ala Ala Lys Pro Ser Gln Pro Gly Glu Gly Leu Lys Lys Pro Val Leu 
945                 950                 955                 960 


Pro Ala Thr Pro Lys Pro Gln Ser Ala Lys Pro Ser Gly Thr Pro Ile 
                965                 970                 975     


Ser Pro Ala Pro Val Pro Ser Thr Leu Pro Ser Ala Ser Ser Ala Leu 
            980                 985                 990         


Ala Gly Asp Gln Pro Ser Ser Thr  Ala Phe Ile Pro Leu  Ile Ser Thr 
        995                 1000                 1005             


Arg Val  Ser Leu Arg Lys Thr  Arg Gln Pro Pro Glu  Arg Ile Ala 
    1010                 1015                 1020             


Ser Gly  Ala Ile Thr Lys Gly  Val Val Leu Asp Ser  Thr Glu Ala 
    1025                 1030                 1035             


Leu Cys  Leu Ala Ile Ser Arg  Asn Ser Glu Gln Met  Ala Ser His 
    1040                 1045                 1050             


Ser Ala  Val Leu Glu Ala Gly  Lys Asn Leu Tyr Thr  Phe Cys Val 
    1055                 1060                 1065             


Ser Tyr  Val Asp Ser Ile Gln  Gln Met Arg Asn Lys  Phe Ala Phe 
    1070                 1075                 1080             


Arg Glu  Ala Ile Asn Lys Leu  Glu Asn Asn Leu Arg  Glu Leu Gln 
    1085                 1090                 1095             


Ile Cys  Pro Ala Thr Ala Gly  Ser Gly Pro Ala Ala  Thr Gln Asp 
    1100                 1105                 1110             


Phe Ser  Lys Leu Leu Ser Ser  Val Lys Glu Ile Ser  Asp Ile Val 
    1115                 1120                 1125             


Gln Arg  
    1130 


<210>  613
<211>  5384
<212>  DNA
<213>  Homo sapiens

<400>  613
aaaatgttgg agatctgcct gaagctggtg ggctgcaaat ccaagaaggg gctgtcctcg       60

tcctccagct gttatctgga agaagccctt cagcggccag tagcatctga ctttgagcct      120

cagggtctga gtgaagccgc tcgttggaac tccaaggaaa accttctcgc tggacccagt      180

gaaaatgacc ccaacctttt cgttgcactg tatgattttg tggccagtgg agataacact      240

ctaagcataa ctaaaggtga aaagctccgg gtcttaggct ataatcacaa tggggaatgg      300

tgtgaagccc aaaccaaaaa tggccaaggc tgggtcccaa gcaactacat cacgccagtc      360

aacagtctgg agaaacactc ctggtaccat gggcctgtgt cccgcaatgc cgctgagtat      420

ctgctgagca gcgggatcaa tggcagcttc ttggtgcgtg agagtgagag cagtcctggc      480

cagaggtcca tctcgctgag atacgaaggg agggtgtacc attacaggat caacactgct      540

tctgatggca agctctacgt ctcctccgag agccgcttca acaccctggc cgagttggtt      600

catcatcatt caacggtggc cgacgggctc atcaccacgc tccattatcc agccccaaag      660

cgcaacaagc ccactgtcta tggtgtgtcc cccaactacg acaagtggga gatggaacgc      720

acggacatca ccatgaagca caagctgggc gggggccagt acggggaggt gtacgagggc      780

gtgtggaaga aatacagcct gacggtggcc gtgaagacct tgaaggagga caccatggag      840

gtggaagagt tcttgaaaga agctgcagtc atgaaagaga tcaaacaccc taacctggtg      900

cagctccttg gggtctgcac ccgggagccc ccgttctata tcatcactga gttcatgacc      960

tacgggaacc tcctggacta cctgagggag tgcaaccggc aggaggtgaa cgccgtggtg     1020

ctgctgtaca tggccactca gatctcgtca gccatggagt acctggagaa gaaaaacttc     1080

atccacagag atcttgctgc ccgaaactgc ctggtagggg agaaccactt ggtgaaggta     1140

gctgattttg gcctgagcag gttgatgaca ggggacacct acacagccca tgctggagcc     1200

aagttcccca tcaaatggac tgcacccgag agcctggcct acaacaagtt ctccatcaag     1260

tccgacgtct gggcatttgg agtattgctt tgggaaattg ctacctatgg catgtcccct     1320

tacccgggaa ttgacctgtc ccaggtgtat gagctgctag agaaggacta ccgcatggag     1380

cgcccagaag gctgcccaga gaaggtctat gaactcatgc gagcatgttg gcagtggaat     1440

ccctctgacc ggccctcctt tgctgaaatc caccaagcct ttgaaacaat gttccaggaa     1500

tccagtatct cagacgaagt ggaaaaggag ctggggaaac aaggcgtccg tggggctgtg     1560

agtaccttgc tgcaggcccc agagctgccc accaagacga ggacctccag gagagctgca     1620

gagcacagag acaccactga cgtgcctgag atgcctcact ccaagggcca gggagagagc     1680

gatcctctgg accatgagcc tgccgtgtct ccattgctcc ctcgaaaaga gcgaggtccc     1740

ccggagggcg gcctgaatga agatgagcgc cttctcccca aagacaaaaa gaccaacttg     1800

ttcagcgcct tgatcaagaa gaagaagaag acagccccaa cccctcccaa acgcagcagc     1860

tccttccggg agatggacgg ccagccggag cgcagagggg ccggcgagga agagggccga     1920

gacatcagca acggggcact ggctttcacc cccttggaca cagctgaccc agccaagtcc     1980

ccaaagccca gcaatggggc tggggtcccc aatggagccc tccgggagtc cgggggctca     2040

ggcttccggt ctccccacct gtggaagaag tccagcacgc tgaccagcag ccgcctagcc     2100

accggcgagg aggagggcgg tggcagctcc agcaagcgct tcctgcgctc ttgctccgcc     2160

tcctgcgttc cccatggggc caaggacacg gagtggaggt cagtcacgct gcctcgggac     2220

ttgcagtcca cgggaagaca gtttgactcg tccacatttg gagggcacaa aagtgagaag     2280

ccggctctgc ctcggaagag ggcaggggag aacaggtctg accaggtgac ccgaggcaca     2340

gtaacgcctc cccccaggct ggtgaaaaag aatgaggaag ctgctgatga ggtcttcaaa     2400

gacatcatgg agtccagccc gggctccagc ccgcccaacc tgactccaaa acccctccgg     2460

cggcaggtca ccgtggcccc tgcctcgggc ctcccccaca aggaagaagc tggaaagggc     2520

agtgccttag ggacccctgc tgcagctgag ccagtgaccc ccaccagcaa agcaggctca     2580

ggtgcaccag ggggcaccag caagggcccc gccgaggagt ccagagtgag gaggcacaag     2640

cactcctctg agtcgccagg gagggacaag gggaaattgt ccaggctcaa acctgccccg     2700

ccgcccccac cagcagcctc tgcagggaag gctggaggaa agccctcgca gagcccgagc     2760

caggaggcgg ccggggaggc agtcctgggc gcaaagacaa aagccacgag tctggttgat     2820

gctgtgaaca gtgacgctgc caagcccagc cagccgggag agggcctcaa aaagcccgtg     2880

ctcccggcca ctccaaagcc acagtccgcc aagccgtcgg ggacccccat cagcccagcc     2940

cccgttccct ccacgttgcc atcagcatcc tcggccctgg caggggacca gccgtcttcc     3000

accgccttca tccctctcat atcaacccga gtgtctcttc ggaaaacccg ccagcctcca     3060

gagcggatcg ccagcggcgc catcaccaag ggcgtggtcc tggacagcac cgaggcgctg     3120

tgcctcgcca tctctaggaa ctccgagcag atggccagcc acagcgcagt gctggaggcc     3180

ggcaaaaacc tctacacgtt ctgcgtgagc tatgtggatt ccatccagca aatgaggaac     3240

aagtttgcct tccgagaggc catcaacaaa ctggagaata atctccggga gcttcagatc     3300

tgcccggcga cagcaggcag tggtccagcg gccactcagg acttcagcaa gctcctcagt     3360

tcggtgaagg aaatcagtga catagtgcag aggtagcagc agtcaggggt caggtgtcag     3420

gcccgtcgga gctgcctgca gcacatgcgg gctcgcccat acccgtgaca gtggctgaca     3480

agggactagt gagtcagcac cttggcccag gagctctgcg ccaggcagag ctgagggccc     3540

tgtggagtcc agctctacta cctacgtttg caccgcctgc cctcccgcac cttcctcctc     3600

cccgctccgt ctctgtcctc gaattttatc tgtggagttc ctgctccgtg gactgcagtc     3660

ggcatgccag gacccgccag ccccgctccc acctagtgcc ccagactgag ctctccaggc     3720

caggtgggaa cggctgatgt ggactgtctt tttcattttt ttctctctgg agcccctcct     3780

cccccggctg ggcctccttc ttccacttct ccaagaatgg aagcctgaac tgaggccttg     3840

tgtgtcaggc cctctgcctg cactccctgg ccttgcccgt cgtgtgctga agacatgttt     3900

caagaaccgc atttcgggaa gggcatgcac gggcatgcac acggctggtc actctgccct     3960

ctgctgctgc ccggggtggg gtgcactcgc catttcctca cgtgcaggac agctcttgat     4020

ttgggtggaa aacagggtgc taaagccaac cagcctttgg gtcctgggca ggtgggagct     4080

gaaaaggatc gaggcatggg gcatgtcctt tccatctgtc cacatcccca gagcccagct     4140

cttgctctct tgtgacgtgc actgtgaatc ctggcaagaa agcttgagtc tcaagggtgg     4200

caggtcactg tcactgccga catccctccc ccagcagaat ggaggcaggg gacaagggag     4260

gcagtggcta gtggggtgaa cagctggtgc caaatagccc cagactgggc ccaggcaggt     4320

ctgcaagggc ccagagtgaa ccgtcctttc acacatctgg gtgccctgaa agggcccttc     4380

ccctccccca ctcctctaag acaaagtaga ttcttacaag gccctttcct ttggaacaag     4440

acagccttca cttttctgag ttcttgaagc atttcaaagc cctgcctctg tgtagccgcc     4500

ctgagagaga atagagctgc cactgggcac ctgcgcacag gtgggaggaa agggcctggc     4560

cagtcctggt cctggctgca ctcttgaact gggcgaatgt cttatttaat taccgtgagt     4620

gacatagcct catgttctgt gggggtcatc agggagggtt aggaaaacca caaacggagc     4680

ccctgaaagc ctcacgtatt tcacagagca cgcctgccat cttctccccg aggctgcccc     4740

aggccggagc ccagatacgg gggctgtgac tctgggcagg gacccggggt ctcctggacc     4800

ttgacagagc agctaactcc gagagcagtg ggcaggtggc cgcccctgag gcttcacgcc     4860

gggagaagcc accttcccac cccttcatac cgcctcgtgc cagcagcctc gcacaggccc     4920

tagctttacg ctcatcacct aaacttgtac tttatttttc tgatagaaat ggtttcctct     4980

ggatcgtttt atgcggttct tacagcacat cacctctttg cccccgacgg ctgtgacgca     5040

gccggaggga ggcactagtc accgacagcg gccttgaaga cagagcaaag cgcccaccca     5100

ggtcccccga ctgcctgtct ccatgaggta ctggtccctt ccttttgtta acgtgatgtg     5160

ccactatatt ttacacgtat ctcttggtat gcatctttta tagacgctct tttctaagtg     5220

gcgtgtgcat agcgtcctgc cctgccccct cgggggcctg tggtggctcc ccctctgctt     5280

ctcggggtcc agtgcatttt gtttctgtat atgattctct gtggtttttt ttgaatccaa     5340

atctgtcctc tgtagtattt tttaaataaa tcagtgttta catt                      5384


<210>  614
<211>  1130
<212>  PRT
<213>  Homo sapiens

<400>  614

Met Leu Glu Ile Cys Leu Lys Leu Val Gly Cys Lys Ser Lys Lys Gly 
1               5                   10                  15      


Leu Ser Ser Ser Ser Ser Cys Tyr Leu Glu Glu Ala Leu Gln Arg Pro 
            20                  25                  30          


Val Ala Ser Asp Phe Glu Pro Gln Gly Leu Ser Glu Ala Ala Arg Trp 
        35                  40                  45              


Asn Ser Lys Glu Asn Leu Leu Ala Gly Pro Ser Glu Asn Asp Pro Asn 
    50                  55                  60                  


Leu Phe Val Ala Leu Tyr Asp Phe Val Ala Ser Gly Asp Asn Thr Leu 
65                  70                  75                  80  


Ser Ile Thr Lys Gly Glu Lys Leu Arg Val Leu Gly Tyr Asn His Asn 
                85                  90                  95      


Gly Glu Trp Cys Glu Ala Gln Thr Lys Asn Gly Gln Gly Trp Val Pro 
            100                 105                 110         


Ser Asn Tyr Ile Thr Pro Val Asn Ser Leu Glu Lys His Ser Trp Tyr 
        115                 120                 125             


His Gly Pro Val Ser Arg Asn Ala Ala Glu Tyr Leu Leu Ser Ser Gly 
    130                 135                 140                 


Ile Asn Gly Ser Phe Leu Val Arg Glu Ser Glu Ser Ser Pro Gly Gln 
145                 150                 155                 160 


Arg Ser Ile Ser Leu Arg Tyr Glu Gly Arg Val Tyr His Tyr Arg Ile 
                165                 170                 175     


Asn Thr Ala Ser Asp Gly Lys Leu Tyr Val Ser Ser Glu Ser Arg Phe 
            180                 185                 190         


Asn Thr Leu Ala Glu Leu Val His His His Ser Thr Val Ala Asp Gly 
        195                 200                 205             


Leu Ile Thr Thr Leu His Tyr Pro Ala Pro Lys Arg Asn Lys Pro Thr 
    210                 215                 220                 


Val Tyr Gly Val Ser Pro Asn Tyr Asp Lys Trp Glu Met Glu Arg Thr 
225                 230                 235                 240 


Asp Ile Thr Met Lys His Lys Leu Gly Gly Gly Gln Phe Gly Glu Val 
                245                 250                 255     


Tyr Glu Gly Val Trp Lys Lys Tyr Ser Leu Thr Val Ala Val Lys Thr 
            260                 265                 270         


Leu Lys Glu Asp Thr Met Glu Val Glu Glu Phe Leu Lys Glu Ala Ala 
        275                 280                 285             


Val Met Lys Glu Ile Lys His Pro Asn Leu Val Gln Leu Leu Gly Val 
    290                 295                 300                 


Cys Thr Arg Glu Pro Pro Phe Tyr Ile Ile Thr Glu Phe Met Thr Tyr 
305                 310                 315                 320 


Gly Asn Leu Leu Asp Tyr Leu Arg Glu Cys Asn Arg Gln Glu Val Asn 
                325                 330                 335     


Ala Val Val Leu Leu Tyr Met Ala Thr Gln Ile Ser Ser Ala Met Glu 
            340                 345                 350         


Tyr Leu Glu Lys Lys Asn Phe Ile His Arg Asp Leu Ala Ala Arg Asn 
        355                 360                 365             


Cys Leu Val Gly Glu Asn His Leu Val Lys Val Ala Asp Phe Gly Leu 
    370                 375                 380                 


Ser Arg Leu Met Thr Gly Asp Thr Tyr Thr Ala His Ala Gly Ala Lys 
385                 390                 395                 400 


Phe Pro Ile Lys Trp Thr Ala Pro Glu Ser Leu Ala Tyr Asn Lys Phe 
                405                 410                 415     


Ser Ile Lys Ser Asp Val Trp Ala Phe Gly Val Leu Leu Trp Glu Ile 
            420                 425                 430         


Ala Thr Tyr Gly Met Ser Pro Tyr Pro Gly Ile Asp Leu Ser Gln Val 
        435                 440                 445             


Tyr Glu Leu Leu Glu Lys Asp Tyr Arg Met Glu Arg Pro Glu Gly Cys 
    450                 455                 460                 


Pro Glu Lys Val Tyr Glu Leu Met Arg Ala Cys Trp Gln Trp Asn Pro 
465                 470                 475                 480 


Ser Asp Arg Pro Ser Phe Ala Glu Ile His Gln Ala Phe Glu Thr Met 
                485                 490                 495     


Phe Gln Glu Ser Ser Ile Ser Asp Glu Val Glu Lys Glu Leu Gly Lys 
            500                 505                 510         


Gln Gly Val Arg Gly Ala Val Ser Thr Leu Leu Gln Ala Pro Glu Leu 
        515                 520                 525             


Pro Thr Lys Thr Arg Thr Ser Arg Arg Ala Ala Glu His Arg Asp Thr 
    530                 535                 540                 


Thr Asp Val Pro Glu Met Pro His Ser Lys Gly Gln Gly Glu Ser Asp 
545                 550                 555                 560 


Pro Leu Asp His Glu Pro Ala Val Ser Pro Leu Leu Pro Arg Lys Glu 
                565                 570                 575     


Arg Gly Pro Pro Glu Gly Gly Leu Asn Glu Asp Glu Arg Leu Leu Pro 
            580                 585                 590         


Lys Asp Lys Lys Thr Asn Leu Phe Ser Ala Leu Ile Lys Lys Lys Lys 
        595                 600                 605             


Lys Thr Ala Pro Thr Pro Pro Lys Arg Ser Ser Ser Phe Arg Glu Met 
    610                 615                 620                 


Asp Gly Gln Pro Glu Arg Arg Gly Ala Gly Glu Glu Glu Gly Arg Asp 
625                 630                 635                 640 


Ile Ser Asn Gly Ala Leu Ala Phe Thr Pro Leu Asp Thr Ala Asp Pro 
                645                 650                 655     


Ala Lys Ser Pro Lys Pro Ser Asn Gly Ala Gly Val Pro Asn Gly Ala 
            660                 665                 670         


Leu Arg Glu Ser Gly Gly Ser Gly Phe Arg Ser Pro His Leu Trp Lys 
        675                 680                 685             


Lys Ser Ser Thr Leu Thr Ser Ser Arg Leu Ala Thr Gly Glu Glu Glu 
    690                 695                 700                 


Gly Gly Gly Ser Ser Ser Lys Arg Phe Leu Arg Ser Cys Ser Ala Ser 
705                 710                 715                 720 


Cys Val Pro His Gly Ala Lys Asp Thr Glu Trp Arg Ser Val Thr Leu 
                725                 730                 735     


Pro Arg Asp Leu Gln Ser Thr Gly Arg Gln Phe Asp Ser Ser Thr Phe 
            740                 745                 750         


Gly Gly His Lys Ser Glu Lys Pro Ala Leu Pro Arg Lys Arg Ala Gly 
        755                 760                 765             


Glu Asn Arg Ser Asp Gln Val Thr Arg Gly Thr Val Thr Pro Pro Pro 
    770                 775                 780                 


Arg Leu Val Lys Lys Asn Glu Glu Ala Ala Asp Glu Val Phe Lys Asp 
785                 790                 795                 800 


Ile Met Glu Ser Ser Pro Gly Ser Ser Pro Pro Asn Leu Thr Pro Lys 
                805                 810                 815     


Pro Leu Arg Arg Gln Val Thr Val Ala Pro Ala Ser Gly Leu Pro His 
            820                 825                 830         


Lys Glu Glu Ala Gly Lys Gly Ser Ala Leu Gly Thr Pro Ala Ala Ala 
        835                 840                 845             


Glu Pro Val Thr Pro Thr Ser Lys Ala Gly Ser Gly Ala Pro Gly Gly 
    850                 855                 860                 


Thr Ser Lys Gly Pro Ala Glu Glu Ser Arg Val Arg Arg His Lys His 
865                 870                 875                 880 


Ser Ser Glu Ser Pro Gly Arg Asp Lys Gly Lys Leu Ser Arg Leu Lys 
                885                 890                 895     


Pro Ala Pro Pro Pro Pro Pro Ala Ala Ser Ala Gly Lys Ala Gly Gly 
            900                 905                 910         


Lys Pro Ser Gln Ser Pro Ser Gln Glu Ala Ala Gly Glu Ala Val Leu 
        915                 920                 925             


Gly Ala Lys Thr Lys Ala Thr Ser Leu Val Asp Ala Val Asn Ser Asp 
    930                 935                 940                 


Ala Ala Lys Pro Ser Gln Pro Gly Glu Gly Leu Lys Lys Pro Val Leu 
945                 950                 955                 960 


Pro Ala Thr Pro Lys Pro Gln Ser Ala Lys Pro Ser Gly Thr Pro Ile 
                965                 970                 975     


Ser Pro Ala Pro Val Pro Ser Thr Leu Pro Ser Ala Ser Ser Ala Leu 
            980                 985                 990         


Ala Gly Asp Gln Pro Ser Ser Thr  Ala Phe Ile Pro Leu  Ile Ser Thr 
        995                 1000                 1005             


Arg Val  Ser Leu Arg Lys Thr  Arg Gln Pro Pro Glu  Arg Ile Ala 
    1010                 1015                 1020             


Ser Gly  Ala Ile Thr Lys Gly  Val Val Leu Asp Ser  Thr Glu Ala 
    1025                 1030                 1035             


Leu Cys  Leu Ala Ile Ser Arg  Asn Ser Glu Gln Met  Ala Ser His 
    1040                 1045                 1050             


Ser Ala  Val Leu Glu Ala Gly  Lys Asn Leu Tyr Thr  Phe Cys Val 
    1055                 1060                 1065             


Ser Tyr  Val Asp Ser Ile Gln  Gln Met Arg Asn Lys  Phe Ala Phe 
    1070                 1075                 1080             


Arg Glu  Ala Ile Asn Lys Leu  Glu Asn Asn Leu Arg  Glu Leu Gln 
    1085                 1090                 1095             


Ile Cys  Pro Ala Thr Ala Gly  Ser Gly Pro Ala Ala  Thr Gln Asp 
    1100                 1105                 1110             


Phe Ser  Lys Leu Leu Ser Ser  Val Lys Glu Ile Ser  Asp Ile Val 
    1115                 1120                 1125             


Gln Arg  
    1130 


<210>  615
<211>  1130
<212>  PRT
<213>  Homo sapiens

<400>  615

Met Leu Glu Ile Cys Leu Lys Leu Val Gly Cys Lys Ser Lys Lys Gly 
1               5                   10                  15      


Leu Ser Ser Ser Ser Ser Cys Tyr Leu Glu Glu Ala Leu Gln Arg Pro 
            20                  25                  30          


Val Ala Ser Asp Phe Glu Pro Gln Gly Leu Ser Glu Ala Ala Arg Trp 
        35                  40                  45              


Asn Ser Lys Glu Asn Leu Leu Ala Gly Pro Ser Glu Asn Asp Pro Asn 
    50                  55                  60                  


Leu Phe Val Ala Leu Tyr Asp Phe Val Ala Ser Gly Asp Asn Thr Leu 
65                  70                  75                  80  


Ser Ile Thr Lys Gly Glu Lys Leu Arg Val Leu Gly Tyr Asn His Asn 
                85                  90                  95      


Gly Glu Trp Cys Glu Ala Gln Thr Lys Asn Gly Gln Gly Trp Val Pro 
            100                 105                 110         


Ser Asn Tyr Ile Thr Pro Val Asn Ser Leu Glu Lys His Ser Trp Tyr 
        115                 120                 125             


His Gly Pro Val Ser Arg Asn Ala Ala Glu Tyr Leu Leu Ser Ser Gly 
    130                 135                 140                 


Ile Asn Gly Ser Phe Leu Val Arg Glu Ser Glu Ser Ser Pro Gly Gln 
145                 150                 155                 160 


Arg Ser Ile Ser Leu Arg Tyr Glu Gly Arg Val Tyr His Tyr Arg Ile 
                165                 170                 175     


Asn Thr Ala Ser Asp Gly Lys Leu Tyr Val Ser Ser Glu Ser Arg Phe 
            180                 185                 190         


Asn Thr Leu Ala Glu Leu Val His His His Ser Thr Val Ala Asp Gly 
        195                 200                 205             


Leu Ile Thr Thr Leu His Tyr Pro Ala Pro Lys Arg Asn Lys Pro Thr 
    210                 215                 220                 


Val Tyr Gly Val Ser Pro Asn Tyr Asp Lys Trp Glu Met Glu Arg Thr 
225                 230                 235                 240 


Asp Ile Thr Met Lys His Lys Leu Gly Gly Gly Gln Phe Gly Glu Val 
                245                 250                 255     


Tyr Glu Gly Val Trp Lys Lys Tyr Ser Leu Thr Val Ala Val Lys Thr 
            260                 265                 270         


Leu Lys Glu Asp Thr Met Glu Val Glu Glu Phe Leu Lys Glu Ala Ala 
        275                 280                 285             


Val Met Lys Glu Ile Lys His Pro Asn Leu Val Gln Leu Leu Gly Val 
    290                 295                 300                 


Cys Thr Arg Glu Pro Pro Phe Tyr Ile Ile Thr Glu Phe Met Thr Tyr 
305                 310                 315                 320 


Gly Asn Leu Leu Asp Tyr Leu Arg Glu Cys Asn Arg Gln Glu Val Asn 
                325                 330                 335     


Ala Val Val Leu Leu Tyr Met Ala Thr Gln Ile Ser Ser Ala Met Glu 
            340                 345                 350         


Tyr Leu Glu Lys Lys Asn Phe Ile His Arg Asp Leu Ala Ala Arg Asn 
        355                 360                 365             


Cys Leu Val Gly Glu Asn His Leu Val Lys Val Ala Asp Phe Gly Leu 
    370                 375                 380                 


Ser Arg Leu Met Thr Gly Asp Thr Tyr Thr Ala His Ala Gly Ala Lys 
385                 390                 395                 400 


Phe Pro Ile Lys Trp Thr Ala Pro Glu Ser Leu Ala Tyr Asn Lys Phe 
                405                 410                 415     


Ser Ile Lys Ser Asp Val Trp Ala Phe Gly Val Leu Leu Trp Glu Ile 
            420                 425                 430         


Ala Thr Tyr Gly Met Ser Pro Tyr Pro Gly Ile Asp Leu Ser Gln Val 
        435                 440                 445             


Tyr Glu Leu Leu Glu Lys Asp Tyr Arg Met Glu Arg Pro Glu Gly Cys 
    450                 455                 460                 


Pro Glu Lys Val Tyr Glu Leu Met Arg Ala Cys Trp Gln Trp Asn Pro 
465                 470                 475                 480 


Ser Asp Arg Pro Ser Phe Ala Glu Ile His Gln Ala Phe Glu Thr Met 
                485                 490                 495     


Phe Gln Glu Ser Ser Ile Ser Asp Glu Val Glu Lys Glu Leu Gly Lys 
            500                 505                 510         


Gln Gly Val Arg Gly Ala Val Ser Thr Leu Leu Gln Ala Pro Glu Leu 
        515                 520                 525             


Pro Thr Lys Thr Arg Thr Ser Arg Arg Ala Ala Glu His Arg Asp Thr 
    530                 535                 540                 


Thr Asp Val Pro Glu Met Pro His Ser Lys Gly Gln Gly Glu Ser Asp 
545                 550                 555                 560 


Pro Leu Asp His Glu Pro Ala Val Ser Pro Leu Leu Pro Arg Lys Glu 
                565                 570                 575     


Arg Gly Pro Pro Glu Gly Gly Leu Asn Glu Asp Glu Arg Leu Leu Pro 
            580                 585                 590         


Lys Asp Lys Lys Thr Asn Leu Phe Ser Ala Leu Ile Lys Lys Lys Lys 
        595                 600                 605             


Lys Thr Ala Pro Thr Pro Pro Lys Arg Ser Ser Ser Phe Arg Glu Met 
    610                 615                 620                 


Asp Gly Gln Pro Glu Arg Arg Gly Ala Gly Glu Glu Glu Gly Arg Asp 
625                 630                 635                 640 


Ile Ser Asn Gly Ala Leu Ala Phe Thr Pro Leu Asp Thr Ala Asp Pro 
                645                 650                 655     


Ala Lys Ser Pro Lys Pro Ser Asn Gly Ala Gly Val Pro Asn Gly Ala 
            660                 665                 670         


Leu Arg Glu Ser Gly Gly Ser Gly Phe Arg Ser Pro His Leu Trp Lys 
        675                 680                 685             


Lys Ser Ser Thr Leu Thr Ser Ser Arg Leu Ala Thr Gly Glu Glu Glu 
    690                 695                 700                 


Gly Gly Gly Ser Ser Ser Lys Arg Phe Leu Arg Ser Cys Ser Ala Ser 
705                 710                 715                 720 


Cys Val Pro His Gly Ala Lys Asp Thr Glu Trp Arg Ser Val Thr Leu 
                725                 730                 735     


Pro Arg Asp Leu Gln Ser Thr Gly Arg Gln Phe Asp Ser Ser Thr Phe 
            740                 745                 750         


Gly Gly His Lys Ser Glu Lys Pro Ala Leu Pro Arg Lys Arg Ala Gly 
        755                 760                 765             


Glu Asn Arg Ser Asp Gln Val Thr Arg Gly Thr Val Thr Pro Pro Pro 
    770                 775                 780                 


Arg Leu Val Lys Lys Asn Glu Glu Ala Ala Asp Glu Val Phe Lys Asp 
785                 790                 795                 800 


Ile Met Glu Ser Ser Pro Gly Ser Ser Pro Pro Asn Leu Thr Pro Lys 
                805                 810                 815     


Pro Leu Arg Arg Gln Val Thr Val Ala Pro Ala Ser Gly Leu Pro His 
            820                 825                 830         


Lys Glu Glu Ala Gly Lys Gly Ser Ala Leu Gly Thr Pro Ala Ala Ala 
        835                 840                 845             


Glu Pro Val Thr Pro Thr Ser Lys Ala Gly Ser Gly Ala Pro Gly Gly 
    850                 855                 860                 


Thr Ser Lys Gly Pro Ala Glu Glu Ser Arg Val Arg Arg His Lys His 
865                 870                 875                 880 


Ser Ser Glu Ser Pro Gly Arg Asp Lys Gly Lys Leu Ser Arg Leu Lys 
                885                 890                 895     


Pro Ala Pro Pro Pro Pro Pro Ala Ala Ser Ala Gly Lys Ala Gly Gly 
            900                 905                 910         


Lys Pro Ser Gln Ser Pro Ser Gln Glu Ala Ala Gly Glu Ala Val Leu 
        915                 920                 925             


Gly Ala Lys Thr Lys Ala Thr Ser Leu Val Asp Ala Val Asn Ser Asp 
    930                 935                 940                 


Ala Ala Lys Pro Ser Gln Pro Gly Glu Gly Leu Lys Lys Pro Val Leu 
945                 950                 955                 960 


Pro Ala Thr Pro Lys Pro Gln Ser Ala Lys Pro Ser Gly Thr Pro Ile 
                965                 970                 975     


Ser Pro Ala Pro Val Pro Ser Thr Leu Pro Ser Ala Ser Ser Ala Leu 
            980                 985                 990         


Ala Gly Asp Gln Pro Ser Ser Thr  Ala Phe Ile Pro Leu  Ile Ser Thr 
        995                 1000                 1005             


Arg Val  Ser Leu Arg Lys Thr  Arg Gln Pro Pro Glu  Arg Ile Ala 
    1010                 1015                 1020             


Ser Gly  Ala Ile Thr Lys Gly  Val Val Leu Asp Ser  Thr Glu Ala 
    1025                 1030                 1035             


Leu Cys  Leu Ala Ile Ser Arg  Asn Ser Glu Gln Met  Ala Ser His 
    1040                 1045                 1050             


Ser Ala  Val Leu Glu Ala Gly  Lys Asn Leu Tyr Thr  Phe Cys Val 
    1055                 1060                 1065             


Ser Tyr  Val Asp Ser Ile Gln  Gln Met Arg Asn Lys  Phe Ala Phe 
    1070                 1075                 1080             


Arg Glu  Ala Ile Asn Lys Leu  Glu Asn Asn Leu Arg  Glu Leu Gln 
    1085                 1090                 1095             


Ile Cys  Pro Ala Thr Ala Gly  Ser Gly Pro Ala Ala  Thr Gln Asp 
    1100                 1105                 1110             


Phe Ser  Lys Leu Leu Ser Ser  Val Lys Glu Ile Ser  Asp Ile Val 
    1115                 1120                 1125             


Gln Arg  
    1130 


<210>  616
<211>  1368
<212>  DNA
<213>  Homo sapiens

<400>  616
atggccagaa aggctctcaa gcttgcttcg tggaccagca tggctcttgc tgcctctggc       60

atctacttct acagtaacaa gtacttggac cctaatgact ttggcgctgt cagggtgggc      120

agagcagttg ctacgacggc tgtcatcagt tacgactacc tcacttccct gaagagtgtc      180

ccttatggct cagaggagta cttgcagctg agatctaaga tccatgattt gttccagagc      240

ttcgatgaca cccctctggg gacggcctcc ctggcccagg tccacaaggc agtgctgcat      300

gatgggcgga cggtggccgt gaaggtccag cacccaaagg tgcgggctca gagctcgaag      360

gacattctcc tgatggaggt gctcgttctg gctgtgaagc agctgttccc agagtttgag      420

tttatgtggc ttgtggatga agccaagaag aacctgcctt tggagctgga tttcctcaat      480

gaagggagga atgctgagaa ggtgtcccag atgctcaggc attttgactt cttgaaggtc      540

ccccgaatcc actgggacct gtccacggag cgggtcctcc tgatggagtt tgtggatggc      600

gggcaggtca atgacagaga ctacatggag aggaacaaga tcgacgtcaa tgagatctca      660

cgccacctgg gcaagatgta tagtgagatg atcttcgtca atggcttcgt gcactgcgat      720

ccccaccccg gcaatgtact ggtgcggaag caccccggca cgggaaaggc ggagattgtc      780

ctgttggacc atgggcttta ccagatgctc acggaagaat tccgcctgaa ttactgccac      840

ctctggcagt ctctgatctg gactgacatg aagagagtga aggagtacag ccagcgactg      900

ggagccgggg atctctaccc cttgtttgcc tgcatgctga cggcgcgatc gtgggactcg      960

gtcaacagag gcatcagcca agctcccgtc actgccactg aggacttaga gattcgcaac     1020

aacgcggcca actacctccc ccagatcagc catctcctca accacgtgcc gcgccagatg     1080

ctgctcatct tgaagaccaa cgacctgctg cgtggcattg aggccgccct gggcacccgc     1140

gccagcgcca gctcctttct caacatgtca cgttgctgca tcagagcgct agctgagcac     1200

aagaagaaga atacctgttc attcttcaga aggacccaga tctctttcag cgaggccttc     1260

aacttatggc agatcaacct ccatgagctc atcctgcgtg tgaaggggtt gaagctggct     1320

gaccgggtct tggccctaat atgctggctg ttccctgctc cactctga                  1368


<210>  617
<211>  530
<212>  PRT
<213>  Homo sapiens

<400>  617

Met Ala Arg Lys Ala Leu Lys Leu Ala Ser Trp Thr Ser Met Ala Leu 
1               5                   10                  15      


Ala Ala Ser Gly Ile Tyr Phe Tyr Ser Asn Lys Tyr Leu Asp Pro Asn 
            20                  25                  30          


Asp Phe Gly Ala Val Arg Val Gly Arg Ala Val Ala Thr Thr Ala Val 
        35                  40                  45              


Ile Ser Tyr Asp Tyr Leu Thr Ser Leu Lys Ser Val Pro Tyr Gly Ser 
    50                  55                  60                  


Glu Glu Tyr Leu Gln Leu Arg Ser Lys Ser Trp Pro Val Phe Leu Gln 
65                  70                  75                  80  


Val His Leu Arg Ser Ala Arg Arg Leu Cys Glu Leu Cys Cys Ala Asn 
                85                  90                  95      


Arg Gly Thr Phe Ile Lys Val Gly Gln His Leu Gly Ala Leu Asp Tyr 
            100                 105                 110         


Leu Leu Pro Glu Glu Tyr Thr Ser Thr Leu Lys Val Leu His Ser Gln 
        115                 120                 125             


Ala Pro Gln Ser Ser Met Gln Glu Ile Arg Gln Val Ile Arg Glu Asp 
    130                 135                 140                 


Leu Gly Lys Glu Ile His Asp Leu Phe Gln Ser Phe Asp Asp Thr Pro 
145                 150                 155                 160 


Leu Gly Thr Ala Ser Leu Ala Gln Val His Lys Ala Val Leu His Asp 
                165                 170                 175     


Gly Arg Thr Val Ala Val Lys Val Gln His Pro Lys Val Arg Ala Gln 
            180                 185                 190         


Ser Ser Lys Asp Ile Leu Leu Met Glu Val Leu Val Leu Ala Val Lys 
        195                 200                 205             


Gln Leu Phe Pro Glu Phe Glu Phe Met Trp Leu Val Asp Glu Ala Lys 
    210                 215                 220                 


Lys Asn Leu Pro Leu Glu Leu Asp Phe Leu Asn Glu Gly Arg Asn Ala 
225                 230                 235                 240 


Glu Lys Val Ser Gln Met Leu Arg His Phe Asp Phe Leu Lys Val Pro 
                245                 250                 255     


Arg Ile His Trp Asp Leu Ser Thr Glu Arg Val Leu Leu Met Glu Phe 
            260                 265                 270         


Val Asp Gly Gly Gln Val Asn Asp Arg Asp Tyr Met Glu Arg Asn Lys 
        275                 280                 285             


Ile Asp Val Asn Glu Ile Ser Arg His Leu Gly Lys Met Tyr Ser Glu 
    290                 295                 300                 


Met Ile Phe Val Asn Gly Phe Val His Cys Asp Pro His Pro Gly Asn 
305                 310                 315                 320 


Val Leu Val Arg Lys His Pro Gly Thr Gly Lys Ala Glu Ile Val Leu 
                325                 330                 335     


Leu Asp His Gly Leu Tyr Gln Met Leu Thr Glu Glu Phe Arg Leu Asn 
            340                 345                 350         


Tyr Cys His Leu Trp Gln Ser Leu Ile Trp Thr Asp Met Lys Arg Val 
        355                 360                 365             


Lys Glu Tyr Ser Gln Arg Leu Gly Ala Gly Asp Leu Tyr Pro Leu Phe 
    370                 375                 380                 


Ala Cys Met Leu Thr Ala Arg Ser Trp Asp Ser Val Asn Arg Gly Ile 
385                 390                 395                 400 


Ser Gln Ala Pro Val Thr Ala Thr Glu Asp Leu Glu Ile Arg Asn Asn 
                405                 410                 415     


Ala Ala Asn Tyr Leu Pro Gln Ile Ser His Leu Leu Asn His Val Pro 
            420                 425                 430         


Arg Gln Met Leu Leu Ile Leu Lys Thr Asn Asp Leu Leu Arg Gly Ile 
        435                 440                 445             


Glu Ala Ala Leu Gly Thr Arg Ala Ser Ala Ser Ser Phe Leu Asn Met 
    450                 455                 460                 


Ser Arg Cys Cys Ile Arg Ala Leu Ala Glu His Lys Lys Lys Asn Thr 
465                 470                 475                 480 


Cys Ser Phe Phe Arg Arg Thr Gln Ile Ser Phe Ser Glu Ala Phe Asn 
                485                 490                 495     


Leu Trp Gln Ile Asn Leu His Glu Leu Ile Leu Arg Val Lys Gly Leu 
            500                 505                 510         


Lys Leu Ala Asp Arg Val Leu Ala Leu Ile Cys Trp Leu Phe Pro Ala 
        515                 520                 525             


Pro Leu 
    530 


<210>  618
<211>  332
<212>  PRT
<213>  Homo sapiens

<400>  618

Glu Glu Tyr Leu Gln Leu Arg Ser Lys Val His Leu Arg Ser Ala Arg 
1               5                   10                  15      


Arg Leu Cys Cys Ala Asn Arg Gly Thr Phe Ile Lys Val Gly Gln His 
            20                  25                  30          


Leu Gly Ala Leu Asp Tyr Leu Leu Pro Glu Glu Tyr Thr Ser Thr Leu 
        35                  40                  45              


Lys Val Leu His Ser Gln Ala Pro Gln Ser Ser Met Gln Glu Ile Arg 
    50                  55                  60                  


Gln Val Ile Arg Glu Asp Leu Gly Lys Glu Val Leu Val Leu Ala Val 
65                  70                  75                  80  


Lys Gln Leu Phe Pro Glu Phe Glu Phe Met Trp Leu Val Asp Glu Ala 
                85                  90                  95      


Lys Lys Asn Leu Pro Leu Glu Leu Asp Phe Leu Asn Glu Gly Arg Asn 
            100                 105                 110         


Ala Glu Lys Val Ser Gln Met Leu Arg His Phe Asp Phe Leu Lys Val 
        115                 120                 125             


Pro Arg Ile His Trp Asp Leu Ser Thr Glu Arg Val Leu Leu Met Glu 
    130                 135                 140                 


Phe Cys Gly Gly Gln Val Asn Asp Arg Asp Tyr Met Glu Arg Asn Lys 
145                 150                 155                 160 


Ile Asp Val Asn Glu Ile Ser Arg His Leu Gly Lys Met Tyr Ser Glu 
                165                 170                 175     


Met Ile Phe Val Asn Gly Phe Val His Cys Asp Pro His Pro Gly Asn 
            180                 185                 190         


Val Leu Val Arg Lys His Pro Gly Thr Gly Lys Ala Glu Ile Val Leu 
        195                 200                 205             


Leu Asp His Gly Leu Tyr Gln Met Leu Thr Glu Glu Phe Arg Leu Asn 
    210                 215                 220                 


Tyr Cys His Leu Trp Gln Ser Leu Ile Trp Thr Asp Met Lys Arg Val 
225                 230                 235                 240 


Lys Glu Tyr Ser Gln Arg Leu Gly Ala Gly Asp Leu Tyr Pro Leu Phe 
                245                 250                 255     


Ala Cys Met Leu Thr Ala Arg Ser Trp Asp Ser Val Asn Arg Gly Ile 
            260                 265                 270         


Ser Gln Ala Pro Val Thr Ala Thr Glu Asp Leu Glu Ile Arg Asn Asn 
        275                 280                 285             


Ala Ala Asn Asn Tyr Leu Pro Gln Ile Ser His Leu Leu Asn Leu Val 
    290                 295                 300                 


Pro Arg Gln Met Leu Leu Ile Leu Lys Thr Asn Asp Leu Leu Lys Gly 
305                 310                 315                 320 


Gly Arg Ala Asp Pro Ala Phe Leu Tyr Lys Val Val 
                325                 330         


<210>  619
<211>  639
<212>  DNA
<213>  Homo sapiens

<400>  619
gagagaagga gagcctgcag acagaggcct ccagcttggt ctgtctcccc acctctacca       60

gcatctgctg agctatgagc caaaccaggg atttacaggg aggaaaagct ttcggactgc      120

tgaaggccca gcaggaagag aggctggatg agatcaacaa gcaattccta gacgatccca      180

aatatagcag tgatgaggat ctgccctcca aactggaagg cttcaaagag aaatacatgg      240

agtttgacct taatggaaat ggcgatattg atatcatgtc cctgaaacga atgctggaga      300

aacttggagt ccccaagact cacctagagc taaagaaatt aattggagag gtgtccagtg      360

gctccgggga gacgttcagc taccctgact ttctcaggat gatgctgggc aagagatctg      420

ccatcctaaa aatgatcctg atgtatgagg aaaaagcgag agaaaaggaa aagccaacag      480

gccccccagc caagaaagct atctctgagt tgccctgatt tgaagggaaa agggatgatg      540

ggattgaagg ggcttctaat gacccagata tggaaacaga agacaaaatt gtaagccaga      600

gtcaacaaat taaataaatt accccctcct ccagatcaa                             639


<210>  620
<211>  147
<212>  PRT
<213>  Homo sapiens

<400>  620

Met Ser Gln Thr Arg Asp Leu Gln Gly Gly Lys Ala Phe Gly Leu Leu 
1               5                   10                  15      


Lys Ala Gln Gln Glu Glu Arg Leu Asp Glu Ile Asn Lys Gln Phe Leu 
            20                  25                  30          


Asp Asp Pro Lys Tyr Ser Ser Asp Glu Asp Leu Pro Ser Lys Leu Glu 
        35                  40                  45              


Gly Phe Lys Glu Lys Tyr Met Glu Phe Asp Leu Asn Gly Asn Gly Asp 
    50                  55                  60                  


Ile Asp Ile Met Ser Leu Lys Arg Met Leu Glu Lys Leu Gly Val Pro 
65                  70                  75                  80  


Lys Thr His Leu Glu Leu Lys Lys Leu Ile Gly Glu Val Ser Ser Gly 
                85                  90                  95      


Ser Gly Glu Thr Phe Ser Tyr Pro Asp Phe Leu Arg Met Met Leu Gly 
            100                 105                 110         


Lys Arg Ser Ala Ile Leu Lys Met Ile Leu Met Tyr Glu Glu Lys Ala 
        115                 120                 125             


Arg Glu Lys Glu Lys Pro Thr Gly Pro Pro Ala Lys Lys Ala Ile Ser 
    130                 135                 140                 


Glu Leu Pro 
145         


<210>  621
<211>  147
<212>  PRT
<213>  Homo sapiens

<400>  621

Met Ser Gln Thr Arg Asp Leu Gln Gly Gly Lys Ala Phe Gly Leu Leu 
1               5                   10                  15      


Lys Ala Gln Gln Glu Glu Arg Leu Asp Glu Ile Asn Lys Gln Phe Leu 
            20                  25                  30          


Asp Asp Pro Lys Tyr Ser Ser Asp Glu Asp Leu Pro Ser Lys Leu Glu 
        35                  40                  45              


Gly Phe Lys Glu Lys Tyr Met Glu Phe Asp Leu Asn Gly Asn Gly Asp 
    50                  55                  60                  


Ile Asp Ile Met Ser Leu Lys Arg Met Leu Glu Lys Leu Gly Val Pro 
65                  70                  75                  80  


Lys Thr His Leu Glu Leu Lys Lys Leu Ile Gly Glu Val Ser Ser Gly 
                85                  90                  95      


Ser Gly Glu Thr Phe Ser Tyr Pro Asp Phe Leu Arg Met Met Leu Gly 
            100                 105                 110         


Lys Arg Ser Ala Ile Leu Lys Met Ile Leu Met Tyr Glu Glu Lys Ala 
        115                 120                 125             


Arg Glu Lys Glu Lys Pro Thr Gly Pro Pro Ala Lys Lys Ala Ile Ser 
    130                 135                 140                 


Glu Leu Pro 
145         


<210>  622
<211>  3008
<212>  DNA
<213>  Homo sapiens

<400>  622
taattatggg tctgtaacca ccctggactg ggtgctcctc actgacggac ttgtctgaac       60

ctctctttgt ctccagcgcc cagcactggg cctggcaaaa cctgagacgc ccggtacatg      120

ttggccaaat gaatgaacca gattcagacc ggcaggggcg ctgtggttta ggaggggcct      180

ggggtttctc ccaggaggtt tttgggcttg cgctggaggg ctctggactc ccgtttgcgc      240

cagtggcctg catcctggtc ctgtcttcct catgtttgaa tttctttgct ttcctagtct      300

ggggagcagg gaggagccct gtgccctgtc ccaggatcca tgggtaggaa caccatggac      360

agggagagca aacggggcca tctgtcacca ggggcttagg gaaggccgag ccagcctggg      420

tcaaagaagt caaaggggct gcctggagga ggcagcctgt cagctggtgc atcagaggct      480

gtggccaggc cagctgggct cggggagcgc cagcctgaga ggagcgcgtg agcgtcgcgg      540

gagcctcggg caccatgagc gacgtggcta ttgtgaagga gggttggctg cacaaacgag      600

gggagtacat caagacctgg cggccacgct acttcctcct caagaatgat ggcaccttca      660

ttggctacaa ggagcggccg caggatgtgg accaacgtga ggctcccctc aacaacttct      720

ctgtggcgca gtgccagctg atgaagacgg agcggccccg gcccaacacc ttcatcatcc      780

gctgcctgca gtggaccact gtcatcgaac gcaccttcca tgtggagact cctgaggagc      840

gggaggagtg gacaaccgcc atccagactg tggctgacgg cctcaagaag caggaggagg      900

aggagatgga cttccggtcg ggctcaccca gtgacaactc aggggctgaa gagatggagg      960

tgtccctggc caagcccaag caccgcgtga ccatgaacga gtttgagtac ctgaagctgc     1020

tgggcaaggg cactttcggc aaggtgatcc tggtgaagga gaaggccaca ggccgctact     1080

acgccatgaa gatcctcaag aaggaagtca tcgtggccaa ggacgaggtg gcccacacac     1140

tcaccgagaa ccgcgtcctg cagaactcca ggcacccctt cctcacagcc ctgaagtact     1200

ctttccagac ccacgaccgc ctctgctttg tcatggagta cgccaacggg ggcgagctgt     1260

tcttccacct gtcccgggag cgtgtgttct ccgaggaccg ggcccgcttc tatggcgctg     1320

agattgtgtc agccctggac tacctgcact cggagaagaa cgtggtgtac cgggacctca     1380

agctggagaa cctcatgctg gacaaggacg ggcacattaa gatcacagac ttcgggctgt     1440

gcaaggaggg gatcaaggac ggtgccacca tgaagacctt ttgcggcaca cctgagtacc     1500

tggcccccga ggtgctggag gacaatgact acggccgtgc agtggactgg tgggggctgg     1560

gcgtggtcat gtacgagatg atgtgcggtc gcctgccctt ctacaaccag gaccatgaga     1620

agctttttga gctcatcctc atggaggaga tccgcttccc gcgcacgctt ggtcccgagg     1680

ccaagtcctt gctttcaggg ctgctcaaga aggaccccaa gcagaggctt ggcgggggct     1740

ccgaggacgc caaggagatc atgcagcatc gcttctttgc cggtatcgtg tggcagcacg     1800

tgtacgagaa gaagctcagc ccacccttca agccccaggt cacgtcggag actgacacca     1860

ggtattttga tgaggagttc acggcccaga tgatcaccat cacaccacct gaccaagatg     1920

acagcatgga gtgtgtggac agcgagcgca ggccccactt cccccagttc tcctactcgg     1980

ccagcggcac ggcctgaggc ggcggtggac tgcgctggac gatagcttgg agggatggag     2040

aggcggcctc gtgccatgat ctgtatttaa tggtttttat ttctcgggtg catttgagag     2100

aagccacgct gtcctctcga gcccagatgg aaagacgttt ttgtgctgtg ggcagcaccc     2160

tcccccgcag cggggtaggg aagaaaacta tcctgcgggt tttaatttat ttcatccagt     2220

ttgttctccg ggtgtggcct cagccctcag aacaatccga ttcacgtagg gaaatgttaa     2280

ggacttctgc agctatgcgc aatgtggcat tggggggccg ggcaggtcct gcccatgtgt     2340

cccctcactc tgtcagccag ccgccctggg ctgtctgtca ccagctatct gtcatctctc     2400

tggggccctg ggcctcagtt caacctggtg gcaccagatg caacctcact atggtatgct     2460

ggccagcacc ctctcctggg ggtggcaggc acacagcagc cccccagcac taaggccgtg     2520

tctctgagga cgtcatcgga ggctgggccc ctgggatggg accagggatg ggggatgggc     2580

cagggtttac ccagtgggac agaggagcaa ggtttaaatt tgttattgtg tattatgttg     2640

ttcaaatgca ttttgggggt ttttaatctt tgtgacagga aagccctccc ccttcccctt     2700

ctgtgtcaca gttcttggtg actgtcccac cgggagcctc cccctcagat gatctctcca     2760

cggtagcact tgaccttttc gacgcttaac ctttccgctg tcgccccagg ccctccctga     2820

ctccctgtgg gggtggccat ccctgggccc ctccacgcct cctggccaga cgctgccgct     2880

gccgctgcac cacggcgttt ttttacaaca ttcaacttta gtatttttac tattataata     2940

taatatggaa ccttccctcc aaattcttca ataaaagttg cttttcaaaa aaaaaaaaaa     3000

aaaaaaaa                                                              3008


<210>  623
<211>  480
<212>  PRT
<213>  Homo sapiens

<400>  623

Met Ser Asp Val Ala Ile Val Lys Glu Gly Trp Leu His Lys Arg Gly 
1               5                   10                  15      


Glu Tyr Ile Lys Thr Trp Arg Pro Arg Tyr Phe Leu Leu Lys Asn Asp 
            20                  25                  30          


Gly Thr Phe Ile Gly Tyr Lys Glu Arg Pro Gln Asp Val Asp Gln Arg 
        35                  40                  45              


Glu Ala Pro Leu Asn Asn Phe Ser Val Ala Gln Cys Gln Leu Met Lys 
    50                  55                  60                  


Thr Glu Arg Pro Arg Pro Asn Thr Phe Ile Ile Arg Cys Leu Gln Trp 
65                  70                  75                  80  


Thr Thr Val Ile Glu Arg Thr Phe His Val Glu Thr Pro Glu Glu Arg 
                85                  90                  95      


Glu Glu Trp Thr Thr Ala Ile Gln Thr Val Ala Asp Gly Leu Lys Lys 
            100                 105                 110         


Gln Glu Glu Glu Glu Met Asp Phe Arg Ser Gly Ser Pro Ser Asp Asn 
        115                 120                 125             


Ser Gly Ala Glu Glu Met Glu Val Ser Leu Ala Lys Pro Lys His Arg 
    130                 135                 140                 


Val Thr Met Asn Glu Phe Glu Tyr Leu Lys Leu Leu Gly Lys Gly Thr 
145                 150                 155                 160 


Phe Gly Lys Val Ile Leu Val Lys Glu Lys Ala Thr Gly Arg Tyr Tyr 
                165                 170                 175     


Ala Met Lys Ile Leu Lys Lys Glu Val Ile Val Ala Lys Asp Glu Val 
            180                 185                 190         


Ala His Thr Leu Thr Glu Asn Arg Val Leu Gln Asn Ser Arg His Pro 
        195                 200                 205             


Phe Leu Thr Ala Leu Lys Tyr Ser Phe Gln Thr His Asp Arg Leu Cys 
    210                 215                 220                 


Phe Val Met Glu Tyr Ala Asn Gly Gly Glu Leu Phe Phe His Leu Ser 
225                 230                 235                 240 


Arg Glu Arg Val Phe Ser Glu Asp Arg Ala Arg Phe Tyr Gly Ala Glu 
                245                 250                 255     


Ile Val Ser Ala Leu Asp Tyr Leu His Ser Glu Lys Asn Val Val Tyr 
            260                 265                 270         


Arg Asp Leu Lys Leu Glu Asn Leu Met Leu Asp Lys Asp Gly His Ile 
        275                 280                 285             


Lys Ile Thr Asp Phe Gly Leu Cys Lys Glu Gly Ile Lys Asp Gly Ala 
    290                 295                 300                 


Thr Met Lys Thr Phe Cys Gly Thr Pro Glu Tyr Leu Ala Pro Glu Val 
305                 310                 315                 320 


Leu Glu Asp Asn Asp Tyr Gly Arg Ala Val Asp Trp Trp Gly Leu Gly 
                325                 330                 335     


Val Val Met Tyr Glu Met Met Cys Gly Arg Leu Pro Phe Tyr Asn Gln 
            340                 345                 350         


Asp His Glu Lys Leu Phe Glu Leu Ile Leu Met Glu Glu Ile Arg Phe 
        355                 360                 365             


Pro Arg Thr Leu Gly Pro Glu Ala Lys Ser Leu Leu Ser Gly Leu Leu 
    370                 375                 380                 


Lys Lys Asp Pro Lys Gln Arg Leu Gly Gly Gly Ser Glu Asp Ala Lys 
385                 390                 395                 400 


Glu Ile Met Gln His Arg Phe Phe Ala Gly Ile Val Trp Gln His Val 
                405                 410                 415     


Tyr Glu Lys Lys Leu Ser Pro Pro Phe Lys Pro Gln Val Thr Ser Glu 
            420                 425                 430         


Thr Asp Thr Arg Tyr Phe Asp Glu Glu Phe Thr Ala Gln Met Ile Thr 
        435                 440                 445             


Ile Thr Pro Pro Asp Gln Asp Asp Ser Met Glu Cys Val Asp Ser Glu 
    450                 455                 460                 


Arg Arg Pro His Phe Pro Gln Phe Ser Tyr Ser Ala Ser Gly Thr Ala 
465                 470                 475                 480 


<210>  624
<211>  480
<212>  PRT
<213>  Homo sapiens

<400>  624

Met Ser Asp Val Ala Ile Val Lys Glu Gly Trp Leu His Lys Arg Gly 
1               5                   10                  15      


Glu Tyr Ile Lys Thr Trp Arg Pro Arg Tyr Phe Leu Leu Lys Asn Asp 
            20                  25                  30          


Gly Thr Phe Ile Gly Tyr Lys Glu Arg Pro Gln Asp Val Asp Gln Arg 
        35                  40                  45              


Glu Ala Pro Leu Asn Asn Phe Ser Val Ala Gln Cys Gln Leu Met Lys 
    50                  55                  60                  


Thr Glu Arg Pro Arg Pro Asn Thr Phe Ile Ile Arg Cys Leu Gln Trp 
65                  70                  75                  80  


Thr Thr Val Ile Glu Arg Thr Phe His Val Glu Thr Pro Glu Glu Arg 
                85                  90                  95      


Glu Glu Trp Thr Thr Ala Ile Gln Thr Val Ala Asp Gly Leu Lys Lys 
            100                 105                 110         


Gln Glu Glu Glu Glu Met Asp Phe Arg Ser Gly Ser Pro Ser Asp Asn 
        115                 120                 125             


Ser Gly Ala Glu Glu Met Glu Val Ser Leu Ala Lys Pro Lys His Arg 
    130                 135                 140                 


Val Thr Met Asn Glu Phe Glu Tyr Leu Lys Leu Leu Gly Lys Gly Thr 
145                 150                 155                 160 


Phe Gly Lys Val Ile Leu Val Lys Glu Lys Ala Thr Gly Arg Tyr Tyr 
                165                 170                 175     


Ala Met Lys Ile Leu Lys Lys Glu Val Ile Val Ala Lys Asp Glu Val 
            180                 185                 190         


Ala His Thr Leu Thr Glu Asn Arg Val Leu Gln Asn Ser Arg His Pro 
        195                 200                 205             


Phe Leu Thr Ala Leu Lys Tyr Ser Phe Gln Thr His Asp Arg Leu Cys 
    210                 215                 220                 


Phe Val Met Glu Tyr Ala Asn Gly Gly Glu Leu Phe Phe His Leu Ser 
225                 230                 235                 240 


Arg Glu Arg Val Phe Ser Glu Asp Arg Ala Arg Phe Tyr Gly Ala Glu 
                245                 250                 255     


Ile Val Ser Ala Leu Asp Tyr Leu His Ser Glu Lys Asn Val Val Tyr 
            260                 265                 270         


Arg Asp Leu Lys Leu Glu Asn Leu Met Leu Asp Lys Asp Gly His Ile 
        275                 280                 285             


Lys Ile Thr Asp Phe Gly Leu Cys Lys Glu Gly Ile Lys Asp Gly Ala 
    290                 295                 300                 


Thr Met Lys Thr Phe Cys Gly Thr Pro Glu Tyr Leu Ala Pro Glu Val 
305                 310                 315                 320 


Leu Glu Asp Asn Asp Tyr Gly Arg Ala Val Asp Trp Trp Gly Leu Gly 
                325                 330                 335     


Val Val Met Tyr Glu Met Met Cys Gly Arg Leu Pro Phe Tyr Asn Gln 
            340                 345                 350         


Asp His Glu Lys Leu Phe Glu Leu Ile Leu Met Glu Glu Ile Arg Phe 
        355                 360                 365             


Pro Arg Thr Leu Gly Pro Glu Ala Lys Ser Leu Leu Ser Gly Leu Leu 
    370                 375                 380                 


Lys Lys Asp Pro Lys Gln Arg Leu Gly Gly Gly Ser Glu Asp Ala Lys 
385                 390                 395                 400 


Glu Ile Met Gln His Arg Phe Phe Ala Gly Ile Val Trp Gln His Val 
                405                 410                 415     


Tyr Glu Lys Lys Leu Ser Pro Pro Phe Lys Pro Gln Val Thr Ser Glu 
            420                 425                 430         


Thr Asp Thr Arg Tyr Phe Asp Glu Glu Phe Thr Ala Gln Met Ile Thr 
        435                 440                 445             


Ile Thr Pro Pro Asp Gln Asp Asp Ser Met Glu Cys Val Asp Ser Glu 
    450                 455                 460                 


Arg Arg Pro His Phe Pro Gln Phe Ser Tyr Ser Ala Ser Ser Thr Ala 
465                 470                 475                 480 


<210>  625
<211>  5263
<212>  DNA
<213>  Homo sapiens

<400>  625
cggggggggc cgcgccgtgc tagccgttgg gcctgcctcg gaggaggcgt cgccgccgcc       60

gctgccgctg ccggcgccgt tgccgctgcc gggaaacaca aggaaaggga accagcgcag      120

cgtggcgatg ggcgggggta gagccccgcc ggagaggctg ggcggctgcc ggtgacagac      180

tgtgccctgt ccacggtgcc tcctgcatgt cctgctgccc tgagctgtcc cgagctaggt      240

gacagcgtac cacgctgcca ccatgaatga ggtgtctgtc atcaaagaag gctggctcca      300

caagcgtggt gaatacatca agacctggag gccacggtac ttcctgctga agagcgacgg      360

ctccttcatt gggtacaagg agaggcccga ggcccctgat cagactctac cccccttaaa      420

caacttctcc gtagcagaat gccagctgat gaagaccgag aggccgcgac ccaacacctt      480

tgtcatacgc tgcctgcagt ggaccacagt catcgagagg accttccacg tggattctcc      540

agacgagagg gaggagtgga tgcgggccat ccagatggtc gccaacagcc tcaagcagcg      600

ggccccaggc gaggacccca tggactacaa gtgtggctcc cccagtgact cctccacgac      660

tgaggagatg gaagtggcgg tcagcaaggc acgggctaaa gtgaccatga atgacttcga      720

ctatctcaaa ctccttggca agggaacctt tggcaaagtc atcctggtgc gggagaaggc      780

cactggccgc tactacgcca tgaagatcct gcggaaggaa gtcatcattg ccaaggatga      840

agtcgctcac acagtcaccg agagccgggt cctccagaac accaggcacc cgttcctcac      900

tgcgctgaag tatgccttcc agacccacga ccgcctgtgc tttgtgatgg agtatgccaa      960

cgggggtgag ctgttcttcc acctgtcccg ggagcgtgtc ttcacagagg agcgggcccg     1020

gttttatggt gcagagattg tctcggctct tgagtacttg cactcgcggg acgtggtata     1080

ccgcgacatc aagctggaaa acctcatgct ggacaaagat ggccacatca agatcactga     1140

ctttggcctc tgcaaagagg gcatcagtga cggggccacc atgaaaacct tctgtgggac     1200

cccggagtac ctggcgcctg aggtgctgga ggacaatgac tatggccggg ccgtggactg     1260

gtgggggctg ggtgtggtca tgtacgagat gatgtgcggc cgcctgccct tctacaacca     1320

ggaccacgag cgcctcttcg agctcatcct catggaagag atccgcttcc cgcgcacgct     1380

cagccccgag gccaagtccc tgcttgctgg gctgcttaag aaggacccca agcagaggct     1440

tggtgggggg cccagcgatg ccaaggaggt catggagcac aggttcttcc tcagcatcaa     1500

ctggcaggac gtggtccaga agaagctcct gccacccttc aaacctcagg tcacgtccga     1560

ggtcgacaca aggtacttcg atgatgaatt taccgcccag tccatcacaa tcacaccccc     1620

tgaccgctat gacagcctgg gcttactgga gctggaccag cggacccact tcccccagtt     1680

ctcctactcg gccagcatcc gcgagtgagc agtctgccca cgcagaggac gcacgctcgc     1740

tgccatcacc gctgggtggt tttttccccc taacttttta cttagccttt ttggtttgtg     1800

tccccacccc cacctcctca ccccctttcc agttcttctt caggcccctc ccagacgcac     1860

cccagcggcc cctgcagccc ctgcctccag cctccagcct cacctttgtg cccagactcg     1920

catttggaag actccacctc ccgcccaggc ctgggctgtt gggcggttgg agattcaggt     1980

tttaatccac acaagcccca gtgaggggtg aagcatggcg cctggggcct gcctgagttt     2040

ctggcctggg tgtcgtgctg gtgtctgcct ccgcgctgct gcatctggac gaaggctgcc     2100

ttctggtggg acgcgacacc cggcagacag tggtgctgcc ttccaggccc cgtggcctag     2160

gctcggagtg gccaggcacg gggcggtcca atcccccacc cgctgtcccc ctatgggggc     2220

agaaaagcaa taatgtccag gggcaggcag gggcccttgg gagctgcagg gctgggggtt     2280

agggctgctc cctggtgaat ggagtcagat cctaggatct gtaccatggg gaaccaggag     2340

tggccgggct gggtgccgcc tcctggtccg gcctcctccc caccaaactg tcctcaccct     2400

atggatgagg caggaggaac atttggggcc aaacctgcct gcctcccagc cccgtgcctt     2460

actagggctt ccttccagct ggccttacct cccgctggac cctgggcctg gcctggcccc     2520

actgggggct atgggctggg ctcaccctct cctctgcggg ggtggagggc caccagcctt     2580

ggctgttaca atcttacacc ggacagtatt gggccccatg gacttggtca gggaggggtg     2640

ggggtgggca tctctggtac ctattggggt ggggggcctc tgaaaaggga ggctcctagg     2700

cccccctcac ccctccctct ccccagggcc ccacgttctg cagccttaag gttgaacatg     2760

agtgcacgtc catgtcagtg ctgtgggact cctgtgcgtg cctcggactg cgtgtgtcgg     2820

cgggacgcag gcacacgtgg gtgtgtgtgc atgtgtgttt gtgtgagggc agcgtgtcct     2880

ccagtgtgca tggtgtgtgg gcttgggccc catccctggc ccgagcattt catcctgtgg     2940

gggaggggtg ctgacctagt gggaggagcc ccactgtgat ccatgagctg ccctgcccac     3000

gcctcccctc cctgtagcaa cacctctggg tgtttggagt ttagcttttg tgggtttgct     3060

ctccctatcc catctcctgt actacacagt tcatggcagg gtggggaggg gtggggttgg     3120

ttcgggtggg tgagggtctt tttcctctgt gtgcgatgtt gttatctgac agttctccgt     3180

ccctactggc ctttctcctc gtcttcatat ttgtacggta caagcaataa agacactcat     3240

ttcagaccag ggcccagcct gcactcacgc cagcccaacc actctgggct ttgccttggt     3300

gatggagtca gacccctggg ccccagctcc tcctgtacta gccgttccct tcagcaagga     3360

gggcactgag ctcagggtga gggcagctgg ggtgtgtgca ggagctcagg ctggagaggg     3420

tgggtggagc tggtgctgtg gggctgaggg gtatgggaag gctccccgca tgtgggggtg     3480

gggtggacag agaccactcc aggccctcag tgctgcttag gctaagagag gtggggtgga     3540

gggacagggc tggaagatct gggtagccca gaatgaggag ggtgcctgtg ctgtcactga     3600

atgagaggga gtggttcatt ccacccggct gccgagcctc agaggggggc attcctatcc     3660

tgccccacct ccctgtttat gctgccacct ggaagccttg aggcccccaa attccagtac     3720

agacccagtg gtgtgttcat ggtggcgtgg ttgctgtcac ctgggagctc ctgagcgttt     3780

ggttagaacc ctgttcagct tggggtcagc cctcccctag tcactgccct ttagcctgga     3840

tgtgtctggg cccctgcact tcccgtgctt gagtcacgtg gctgcatggc cgggcgctgg     3900

ccggatggaa cacctccccc agcaagggac cagggaccag agccctggcc tgccctgctg     3960

agccctgctg tgcagagggc ctggcacaga tgaatttgag attttgccgc aaggtgttag     4020

cacttcacac ccattgagtc tttgagattt taagtgaatg taagcagaaa aagtcagatc     4080

caatttacag aaatcagagt tagctacagc taggactcgt ttggttgggg ttttttagtt     4140

tgtctttcta aagtcatgtg gaccttaatt taattacaaa agtctaccct ggtggtcata     4200

aaataggcag gcctatgaag aaaggccttt tactcttcca tctcatccca gccccgagtt     4260

gacccacgtt gctgctcctc acaccatggt gatgcaggtc tcgtagtgtg ggcacaggcc     4320

tggctacctc atctttttag tgcctctctc ctcttccaca ggatggggtc ccacagctgc     4380

agcagctggc cccgtagttg agcatgtgtg gttatcctgt agagcttttc ccaagaaggg     4440

tgtttgaact tagagtctta ataaaatctt accaaataaa ttttgagtag aataatcgtc     4500

ttttgcaatg tacattttaa aaatttcaca cattcttttt tgtatataaa gaacagtgac     4560

tgggcacagt ggctcatgcc tgtaatccca gcaatttggg aggccgaggc gggcgggtct     4620

cttgaggcca ggggttcgag accagcctgg gcatcatagg gagaccttca tctctacaaa     4680

aaatacaaaa attagctggg catggtggtg catgcctgca atcccagcta acttggaagg     4740

ctgaggtgag gtgggaagat cacttgagcc caggagtttg aggctgcagt gagctatgat     4800

tgcggcactg cactgcagcc tgggacaatg agactgtgtc tctaaaaata aaaaaaaaaa     4860

aaacatgata catgctatta aaaaagacag caaagcagga gtataagaaa ggaaattcac     4920

ccgaggtcgc agggccttga gtactcattt tggtgctgat tacctctctg caaatggaca     4980

cggcatcata aattggtagt ttcctgctct ttttgtgtaa tcttttccag ttaatgtgaa     5040

gcctctgggg gctgccctcg tgcactgatg gttgtgtgga gtcgggggcg gcagtgcgat     5100

tcccttttag ctgctgcatg gggggaactc aggctttcca gctgcttcct ggggttccat     5160

ggggtagacc cctcaaccgc ttcagctgcc ccgttaacag gaattgactt ggtttcgttt     5220

ggtgctacca gcagtcctgt aataaactag ctatccatct gta                       5263


<210>  626
<211>  481
<212>  PRT
<213>  Homo sapiens

<400>  626

Met Asn Glu Val Ser Val Ile Lys Glu Gly Trp Leu His Lys Arg Gly 
1               5                   10                  15      


Glu Tyr Ile Lys Thr Trp Arg Pro Arg Tyr Phe Leu Leu Lys Ser Asp 
            20                  25                  30          


Gly Ser Phe Ile Gly Tyr Lys Glu Arg Pro Glu Ala Pro Asp Gln Thr 
        35                  40                  45              


Leu Pro Pro Leu Asn Asn Phe Ser Val Ala Glu Cys Gln Leu Met Lys 
    50                  55                  60                  


Thr Glu Arg Pro Arg Pro Asn Thr Phe Val Ile Arg Cys Leu Gln Trp 
65                  70                  75                  80  


Thr Thr Val Ile Glu Arg Thr Phe His Val Asp Ser Pro Asp Glu Arg 
                85                  90                  95      


Glu Glu Trp Met Arg Ala Ile Gln Met Val Ala Asn Ser Leu Lys Gln 
            100                 105                 110         


Arg Ala Pro Gly Glu Asp Pro Met Asp Tyr Lys Cys Gly Ser Pro Ser 
        115                 120                 125             


Asp Ser Ser Thr Thr Glu Glu Met Glu Val Ala Val Ser Lys Ala Arg 
    130                 135                 140                 


Ala Lys Val Thr Met Asn Asp Phe Asp Tyr Leu Lys Leu Leu Gly Lys 
145                 150                 155                 160 


Gly Thr Phe Gly Lys Val Ile Leu Val Arg Glu Lys Ala Thr Gly Arg 
                165                 170                 175     


Tyr Tyr Ala Met Lys Ile Leu Arg Lys Glu Val Ile Ile Ala Lys Asp 
            180                 185                 190         


Glu Val Ala His Thr Val Thr Glu Ser Arg Val Leu Gln Asn Thr Arg 
        195                 200                 205             


His Pro Phe Leu Thr Ala Leu Lys Tyr Ala Phe Gln Thr His Asp Arg 
    210                 215                 220                 


Leu Cys Phe Val Met Glu Tyr Ala Asn Gly Gly Glu Leu Phe Phe His 
225                 230                 235                 240 


Leu Ser Arg Glu Arg Val Phe Thr Glu Glu Arg Ala Arg Phe Tyr Gly 
                245                 250                 255     


Ala Glu Ile Val Ser Ala Leu Glu Tyr Leu His Ser Arg Asp Val Val 
            260                 265                 270         


Tyr Arg Asp Ile Lys Leu Glu Asn Leu Met Leu Asp Lys Asp Gly His 
        275                 280                 285             


Ile Lys Ile Thr Asp Phe Gly Leu Cys Lys Glu Gly Ile Ser Asp Gly 
    290                 295                 300                 


Ala Thr Met Lys Thr Phe Cys Gly Thr Pro Glu Tyr Leu Ala Pro Glu 
305                 310                 315                 320 


Val Leu Glu Asp Asn Asp Tyr Gly Arg Ala Val Asp Trp Trp Gly Leu 
                325                 330                 335     


Gly Val Val Met Tyr Glu Met Met Cys Gly Arg Leu Pro Phe Tyr Asn 
            340                 345                 350         


Gln Asp His Glu Arg Leu Phe Glu Leu Ile Leu Met Glu Glu Ile Arg 
        355                 360                 365             


Phe Pro Arg Thr Leu Ser Pro Glu Ala Lys Ser Leu Leu Ala Gly Leu 
    370                 375                 380                 


Leu Lys Lys Asp Pro Lys Gln Arg Leu Gly Gly Gly Pro Ser Asp Ala 
385                 390                 395                 400 


Lys Glu Val Met Glu His Arg Phe Phe Leu Ser Ile Asn Trp Gln Asp 
                405                 410                 415     


Val Val Gln Lys Lys Leu Leu Pro Pro Phe Lys Pro Gln Val Thr Ser 
            420                 425                 430         


Glu Val Asp Thr Arg Tyr Phe Asp Asp Glu Phe Thr Ala Gln Ser Ile 
        435                 440                 445             


Thr Ile Thr Pro Pro Asp Arg Tyr Asp Ser Leu Gly Leu Leu Glu Leu 
    450                 455                 460                 


Asp Gln Arg Thr His Phe Pro Gln Phe Ser Tyr Ser Ala Ser Ile Arg 
465                 470                 475                 480 


Glu 
    


<210>  627
<211>  481
<212>  PRT
<213>  Homo sapiens

<400>  627

Met Asn Glu Val Ser Val Ile Lys Glu Gly Trp Leu His Lys Arg Gly 
1               5                   10                  15      


Glu Tyr Ile Lys Thr Trp Arg Pro Arg Tyr Phe Leu Leu Lys Ser Asp 
            20                  25                  30          


Gly Ser Phe Ile Gly Tyr Lys Glu Arg Pro Glu Ala Pro Asp Gln Thr 
        35                  40                  45              


Leu Pro Pro Leu Asn Asn Phe Ser Val Ala Glu Cys Gln Leu Met Lys 
    50                  55                  60                  


Thr Glu Arg Pro Arg Pro Asn Thr Phe Val Ile Arg Cys Leu Gln Trp 
65                  70                  75                  80  


Thr Thr Val Ile Glu Arg Thr Phe His Val Asp Ser Pro Asp Glu Arg 
                85                  90                  95      


Glu Glu Trp Met Arg Ala Ile Gln Met Val Ala Asn Ser Leu Lys Gln 
            100                 105                 110         


Arg Ala Pro Gly Glu Asp Pro Met Asp Tyr Lys Cys Gly Ser Pro Ser 
        115                 120                 125             


Asp Ser Ser Thr Thr Glu Glu Met Glu Val Ala Val Ser Lys Ala Arg 
    130                 135                 140                 


Ala Lys Val Thr Met Asn Asp Phe Asp Tyr Leu Lys Leu Leu Gly Lys 
145                 150                 155                 160 


Gly Thr Phe Gly Lys Val Ile Leu Val Arg Glu Lys Ala Thr Gly Arg 
                165                 170                 175     


Tyr Tyr Ala Met Lys Ile Leu Arg Lys Glu Val Ile Ile Ala Lys Asp 
            180                 185                 190         


Glu Val Ala His Thr Val Thr Glu Ser Arg Val Leu Gln Asn Thr Arg 
        195                 200                 205             


His Pro Phe Leu Thr Ala Leu Lys Tyr Ala Phe Gln Thr His Asp Arg 
    210                 215                 220                 


Leu Cys Phe Val Met Glu Tyr Ala Asn Gly Gly Glu Leu Phe Phe His 
225                 230                 235                 240 


Leu Ser Arg Glu Arg Val Phe Thr Glu Glu Arg Ala Arg Phe Tyr Gly 
                245                 250                 255     


Ala Glu Ile Val Ser Ala Leu Glu Tyr Leu His Ser Arg Asp Val Val 
            260                 265                 270         


Tyr Arg Asp Ile Lys Leu Glu Asn Leu Met Leu Asp Lys Asp Gly His 
        275                 280                 285             


Ile Lys Ile Thr Asp Phe Gly Leu Cys Lys Glu Gly Ile Ser Asp Gly 
    290                 295                 300                 


Ala Thr Met Lys Thr Phe Cys Gly Thr Pro Glu Tyr Leu Ala Pro Glu 
305                 310                 315                 320 


Val Leu Glu Asp Asn Asp Tyr Gly Arg Ala Val Asp Trp Trp Gly Leu 
                325                 330                 335     


Gly Val Val Met Tyr Glu Met Met Cys Gly Arg Leu Pro Phe Tyr Asn 
            340                 345                 350         


Gln Asp His Glu Arg Leu Phe Glu Leu Ile Leu Met Glu Glu Ile Arg 
        355                 360                 365             


Phe Pro Arg Thr Leu Ser Pro Glu Ala Lys Ser Leu Leu Ala Gly Leu 
    370                 375                 380                 


Leu Lys Lys Asp Pro Lys Gln Arg Leu Gly Gly Gly Pro Ser Asp Ala 
385                 390                 395                 400 


Lys Glu Val Met Glu His Arg Phe Phe Leu Ser Ile Asn Trp Gln Asp 
                405                 410                 415     


Val Val Gln Lys Lys Leu Leu Pro Pro Phe Lys Pro Gln Val Thr Ser 
            420                 425                 430         


Glu Val Asp Thr Arg Tyr Phe Asp Asp Glu Phe Thr Ala Gln Ser Ile 
        435                 440                 445             


Thr Ile Thr Pro Pro Asp Arg Tyr Asp Ser Leu Gly Leu Leu Glu Leu 
    450                 455                 460                 


Asp Gln Arg Thr His Phe Pro Gln Phe Ser Tyr Ser Ala Ser Ile Arg 
465                 470                 475                 480 


Glu 
    


<210>  628
<211>  3588
<212>  DNA
<213>  Homo sapiens

<400>  628
gcagcagcag agaatccaaa ccctaaagct gatatcacaa agtaccattt ctccaagttg       60

ggggctcaga ggggagtcat catgagcgat gttaccattg tgaaagaagg ttgggttcag      120

aagaggggag aatatataaa aaactggagg ccaagatact tccttttgaa gacagatggc      180

tcattcatag gatataaaga gaaacctcaa gatgtggatt taccttatcc cctcaacaac      240

ttttcagtgg caaaatgcca gttaatgaaa acagaacgac caaagccaaa cacatttata      300

atcagatgtc tccagtggac tactgttata gagagaacat ttcatgtaga tactccagag      360

gaaagggaag aatggacaga agctatccag gctgtagcag acagactgca gaggcaagaa      420

gaggagagaa tgaattgtag tccaacttca caaattgata atataggaga ggaagagatg      480

gatgcctcta caacccatca taaaagaaag acaatgaatg attttgacta tttgaaacta      540

ctaggtaaag gcacttttgg gaaagttatt ttggttcgag agaaggcaag tggaaaatac      600

tatgctatga agattctgaa gaaagaagtc attattgcaa aggatgaagt ggcacacact      660

ctaactgaaa gcagagtatt aaagaacact agacatccct ttttaacatc cttgaaatat      720

tccttccaga caaaagaccg tttgtgtttt gtgatggaat atgttaatgg gggcgagctg      780

tttttccatt tgtcgagaga gcgggtgttc tctgaggacc gcacacgttt ctatggtgca      840

gaaattgtct ctgccttgga ctatctacat tccggaaaga ttgtgtaccg tgatctcaag      900

ttggagaatc taatgctgga caaagatggc cacataaaaa ttacagattt tggactttgc      960

aaagaaggga tcacagatgc agccaccatg aagacattct gtggcactcc agaatatctg     1020

gcaccagagg tgttagaaga taatgactat ggccgagcag tagactggtg gggcctaggg     1080

gttgtcatgt atgaaatgat gtgtgggagg ttacctttct acaaccagga ccatgagaaa     1140

ctttttgaat taatattaat ggaagacatt aaatttcctc gaacactctc ttcagatgca     1200

aaatcattgc tttcagggct cttgataaag gatccaaata aacgccttgg tggaggacca     1260

gatgatgcaa aagaaattat gagacacagt ttcttctctg gagtaaactg gcaagatgta     1320

tatgataaaa agcttgtacc tccttttaaa cctcaagtaa catctgagac agatactaga     1380

tattttgatg aagaatttac agctcagact attacaataa caccacctga aaaatatgat     1440

gaggatggta tggactgcat ggacaatgag aggcggccgc atttccctca attttcctac     1500

tctgcaagtg gacgagaata agtctctttc attctgctac ttcactgtca tcttcaattt     1560

attactgaaa atgattcctg gacatcacca gtcctagctc ttacacatag caggggcacc     1620

ttccgacatc ccagaccagc caagggtcct cacccctcgc cacctttcac cctcatgaaa     1680

acacacatac acgcaaatac actccagttt ttgtttttgc atgaaattgt atctcagtct     1740

aaggtctcat gctgttgctg ctactgtctt actattatag caactttaag aagtaatttt     1800

ccaacctttg gaagtcatga gcccaccatt gttcatttgt gcaccaatta tcatcttttg     1860

atcttttagt ttttccctca gtgaaggcta aatgagatac actgattcta ggtacatttt     1920

ttaactttct agaagagaaa aactaactag actaagaaga tttagtttat aaattcagaa     1980

caagcaattg tggaagggtg gtggcgtgca tatgtaaagc acatcagatc cgtgcgtgaa     2040

gtaggcatat atcactaagc tgtggctgga attgattagg aagcatttgg tagaaggact     2100

gaacaactgt tgggatatat atatatatat ataatttttt ttttttaaat tcctggtgga     2160

tactgtagaa gaagcccata tcacatgtgg atgtcgagac ttcacgggca atcatgagca     2220

agtgaacact gttctaccaa gaactgaagg catatgcaca gtcaaggtca cttaaagggt     2280

cttatgaaac aatttgagcc agagagcatc tttcccctgt gcttggaaac cttttttcct     2340

tcttgacatt tatcacctct gatggctgaa gaatgtagac aggtataatg atactgcttt     2400

tcaccaaaat ttctacacca aggtaaacag gtgtttgcct tatttaattt tttactttca     2460

gttctacgtg aattagcttt ttctcagatg ttgaaacttt gaatgtcctt ttatgatttt     2520

gtttatattg cagtagtatt tattttttag tgatgagaat tgtatgtcat gttagcaaac     2580

gcagctccaa cttatataaa atagacttac tgcagttact tttgacccat gtgcaaggat     2640

tgtacacgct gatgagaatc atgcactttt tctcctctgt taaaaaaaat gataaggctc     2700

tgaaatggaa tatattggtt agaatttggc tttgggagaa gagatgctgc catttaaccc     2760

cttggtactg aaaatgagaa aatccccaac tatgcatgcc aaggggttaa tgaaacaaat     2820

agctgttgac gtttgctcat ttaagaattt gaaacgttat gatgacctgg caacaaaaag     2880

taatgaagaa aattgagacc tgagtgaaga taagaaatga tctttacgtg gcaaaatgaa     2940

cacatcttga gtatttagga aatgggcagt gaaggctaag aacctggtgt gtttcttggg     3000

atcatggtac atttatcact gaattaagcc atcagggaaa aaacaacaaa aaaagagaac     3060

acctccagct tttctttttc tgtatatact catgtccccc agattccaac atttctcact     3120

gaaagggggc atgtatgcaa acctcatctt tctccttcat taatgatgat cttcagatta     3180

aaccctttgg tgctaggagc tgacaatttc caaagcagcc tgtgaagtcc taggggctgg     3240

gggccactct tgcggcaagc agaaggccat cctactccgc ggagtgatca tggaaatgta     3300

ttttagttaa actctgacag ctcccaaacg gaagactaca gcatgacgta gtattatgat     3360

tgcattgtat gaaagagcaa gtgactttct aagtaggatg aatcatattc atatgcagat     3420

gtcttagcct cttgacgctg gaagtgtgga tttatagcta tgaaaccact gctggcagtg     3480

ggtgggccac tgggactgac gggggttaaa gggcatttta ctaaggcagc taagacatat     3540

tcagacatca acgttatcct tctttttcat atttctacct gagtgaag                  3588


<210>  629
<211>  479
<212>  PRT
<213>  Homo sapiens

<400>  629

Met Ser Asp Val Thr Ile Val Lys Glu Gly Trp Val Gln Lys Arg Gly 
1               5                   10                  15      


Glu Tyr Ile Lys Asn Trp Arg Pro Arg Tyr Phe Leu Leu Lys Thr Asp 
            20                  25                  30          


Gly Ser Phe Ile Gly Tyr Lys Glu Lys Pro Gln Asp Val Asp Leu Pro 
        35                  40                  45              


Tyr Pro Leu Asn Asn Phe Ser Val Ala Lys Cys Gln Leu Met Lys Thr 
    50                  55                  60                  


Glu Arg Pro Lys Pro Asn Thr Phe Ile Ile Arg Cys Leu Gln Trp Thr 
65                  70                  75                  80  


Thr Val Ile Glu Arg Thr Phe His Val Asp Thr Pro Glu Glu Arg Glu 
                85                  90                  95      


Glu Trp Thr Glu Ala Ile Gln Ala Val Ala Asp Arg Leu Gln Arg Gln 
            100                 105                 110         


Glu Glu Glu Arg Met Asn Cys Ser Pro Thr Ser Gln Ile Asp Asn Ile 
        115                 120                 125             


Gly Glu Glu Glu Met Asp Ala Ser Thr Thr His His Lys Arg Lys Thr 
    130                 135                 140                 


Met Asn Asp Phe Asp Tyr Leu Lys Leu Leu Gly Lys Gly Thr Phe Gly 
145                 150                 155                 160 


Lys Val Ile Leu Val Arg Glu Lys Ala Ser Gly Lys Tyr Tyr Ala Met 
                165                 170                 175     


Lys Ile Leu Lys Lys Glu Val Ile Ile Ala Lys Asp Glu Val Ala His 
            180                 185                 190         


Thr Leu Thr Glu Ser Arg Val Leu Lys Asn Thr Arg His Pro Phe Leu 
        195                 200                 205             


Thr Ser Leu Lys Tyr Ser Phe Gln Thr Lys Asp Arg Leu Cys Phe Val 
    210                 215                 220                 


Met Glu Tyr Val Asn Gly Gly Glu Leu Phe Phe His Leu Ser Arg Glu 
225                 230                 235                 240 


Arg Val Phe Ser Glu Asp Arg Thr Arg Phe Tyr Gly Ala Glu Ile Val 
                245                 250                 255     


Ser Ala Leu Asp Tyr Leu His Ser Gly Lys Ile Val Tyr Arg Asp Leu 
            260                 265                 270         


Lys Leu Glu Asn Leu Met Leu Asp Lys Asp Gly His Ile Lys Ile Thr 
        275                 280                 285             


Asp Phe Gly Leu Cys Lys Glu Gly Ile Thr Asp Ala Ala Thr Met Lys 
    290                 295                 300                 


Thr Phe Cys Gly Thr Pro Glu Tyr Leu Ala Pro Glu Val Leu Glu Asp 
305                 310                 315                 320 


Asn Asp Tyr Gly Arg Ala Val Asp Trp Trp Gly Leu Gly Val Val Met 
                325                 330                 335     


Tyr Glu Met Met Cys Gly Arg Leu Pro Phe Tyr Asn Gln Asp His Glu 
            340                 345                 350         


Lys Leu Phe Glu Leu Ile Leu Met Glu Asp Ile Lys Phe Pro Arg Thr 
        355                 360                 365             


Leu Ser Ser Asp Ala Lys Ser Leu Leu Ser Gly Leu Leu Ile Lys Asp 
    370                 375                 380                 


Pro Asn Lys Arg Leu Gly Gly Gly Pro Asp Asp Ala Lys Glu Ile Met 
385                 390                 395                 400 


Arg His Ser Phe Phe Ser Gly Val Asn Trp Gln Asp Val Tyr Asp Lys 
                405                 410                 415     


Lys Leu Val Pro Pro Phe Lys Pro Gln Val Thr Ser Glu Thr Asp Thr 
            420                 425                 430         


Arg Tyr Phe Asp Glu Glu Phe Thr Ala Gln Thr Ile Thr Ile Thr Pro 
        435                 440                 445             


Pro Glu Lys Tyr Asp Glu Asp Gly Met Asp Cys Met Asp Asn Glu Arg 
    450                 455                 460                 


Arg Pro His Phe Pro Gln Phe Ser Tyr Ser Ala Ser Gly Arg Glu 
465                 470                 475                 


<210>  630
<211>  479
<212>  PRT
<213>  Homo sapiens

<400>  630

Met Ser Asp Val Thr Ile Val Lys Glu Gly Trp Val Gln Lys Arg Gly 
1               5                   10                  15      


Glu Tyr Ile Lys Asn Trp Arg Pro Arg Tyr Phe Leu Leu Lys Thr Asp 
            20                  25                  30          


Gly Ser Phe Ile Gly Tyr Lys Glu Lys Pro Gln Asp Val Asp Leu Pro 
        35                  40                  45              


Tyr Pro Leu Asn Asn Phe Ser Val Ala Lys Cys Gln Leu Met Lys Thr 
    50                  55                  60                  


Glu Arg Pro Lys Pro Asn Thr Phe Ile Ile Arg Cys Leu Gln Trp Thr 
65                  70                  75                  80  


Thr Val Ile Glu Arg Thr Phe His Val Asp Thr Pro Glu Glu Arg Glu 
                85                  90                  95      


Glu Trp Thr Glu Ala Ile Gln Ala Val Ala Asp Arg Leu Gln Arg Gln 
            100                 105                 110         


Glu Glu Glu Arg Met Asn Cys Ser Pro Thr Ser Gln Ile Asp Asn Ile 
        115                 120                 125             


Gly Glu Glu Glu Met Asp Ala Ser Thr Thr His His Lys Arg Lys Thr 
    130                 135                 140                 


Met Asn Asp Phe Asp Tyr Leu Lys Leu Leu Gly Lys Gly Thr Phe Gly 
145                 150                 155                 160 


Lys Val Ile Leu Val Arg Glu Lys Ala Ser Gly Lys Tyr Tyr Ala Met 
                165                 170                 175     


Lys Ile Leu Lys Lys Glu Val Ile Ile Ala Lys Asp Glu Val Ala His 
            180                 185                 190         


Thr Leu Thr Glu Ser Arg Val Leu Lys Asn Thr Arg His Pro Phe Leu 
        195                 200                 205             


Thr Ser Leu Lys Tyr Ser Phe Gln Thr Lys Asp Arg Leu Cys Phe Val 
    210                 215                 220                 


Met Glu Tyr Val Asn Gly Gly Glu Leu Phe Phe His Leu Ser Arg Glu 
225                 230                 235                 240 


Arg Val Phe Ser Glu Asp Arg Thr Arg Phe Tyr Gly Ala Glu Ile Val 
                245                 250                 255     


Ser Ala Leu Asp Tyr Leu His Ser Gly Lys Ile Val Tyr Arg Asp Leu 
            260                 265                 270         


Lys Leu Glu Asn Leu Met Leu Asp Lys Asp Gly His Ile Lys Ile Thr 
        275                 280                 285             


Asp Phe Gly Leu Cys Lys Glu Gly Ile Thr Asp Ala Ala Thr Met Lys 
    290                 295                 300                 


Thr Phe Cys Gly Thr Pro Glu Tyr Leu Ala Pro Glu Val Leu Glu Asp 
305                 310                 315                 320 


Asn Asp Tyr Gly Arg Ala Val Asp Trp Trp Gly Leu Gly Val Val Met 
                325                 330                 335     


Tyr Glu Met Met Cys Gly Arg Leu Pro Phe Tyr Asn Gln Asp His Glu 
            340                 345                 350         


Lys Leu Phe Glu Leu Ile Leu Met Glu Asp Ile Lys Phe Pro Arg Thr 
        355                 360                 365             


Leu Ser Ser Asp Ala Lys Ser Leu Leu Ser Gly Leu Leu Ile Lys Asp 
    370                 375                 380                 


Pro Asn Lys Arg Leu Gly Gly Gly Pro Asp Asp Ala Lys Glu Ile Met 
385                 390                 395                 400 


Arg His Ser Phe Phe Ser Gly Val Asn Trp Gln Asp Val Tyr Asp Lys 
                405                 410                 415     


Lys Leu Val Pro Pro Phe Lys Pro Gln Val Thr Ser Glu Thr Asp Thr 
            420                 425                 430         


Arg Tyr Phe Asp Glu Glu Phe Thr Ala Gln Thr Ile Thr Ile Thr Pro 
        435                 440                 445             


Pro Glu Lys Tyr Asp Glu Asp Gly Met Asp Cys Met Asp Asn Glu Arg 
    450                 455                 460                 


Arg Pro His Phe Pro Gln Phe Ser Tyr Ser Ala Ser Gly Arg Glu 
465                 470                 475                 


<210>  631
<211>  3130
<212>  DNA
<213>  Homo sapiens

<400>  631
cccgagatgc tgctgccggc gcccgcgctc cgccgcgccc tgctgtcccg cccctggacc       60

ggggccggcc tgcggtggaa gcacacctcc tccctgaagg tggccaacga gcccgtctta      120

gccttcacgc agggcagccc tgagcgagat gccctgcaaa aggccttgaa ggacctgaag      180

ggccggatgg aagccatccc atgcgtggtg ggggatgagg aggtgtggac gtcggacgtg      240

cagtaccaag tgtcgccttt taaccatgga cataaggtgg ccaagttctg ttatgcagac      300

aagagcctgc tcaacaaagc cattgaggct gccctggctg cccggaaaga gtgggacctg      360

aagcctattg cagaccgggc ccagatcttc ctgaaggcgg cagacatgct gagtgggccg      420

cgcagggctg agatcctcgc caagaccatg gtgggacagg gtaagaccgt gatccaagcg      480

gagattgacg ctgcagcgga actcatcgac ttcttccggt tcaatgccaa gtatgcggtg      540

gagctggagg ggcagcagcc catcagcgtg cccccgagca ccaacagcac ggtgtaccgg      600

ggtctggagg gcttcgtggc ggccatctcg ccctttaact tcactgcaat cggcggcaac      660

ctggcggggg caccggccct gatgggcaac gtggtcctat ggaagcccag tgacactgcc      720

atgctggcca gctatgctgt ctaccgcatc cttcgggagg ctggcctgcc ccccaacatc      780

atccagtttg tgccagctga tgggccccta tttggggaca ctgtcaccag ctcagagcac      840

ctctgtggca tcaacttcac aggcagtgtg cccaccttca aacacctgtg gaagcaggtg      900

gcccagaacc tggaccggtt ccacaccttc ccacgcctgg ctggagagtg cggcggaaag      960

aacttccact tcgtgcaccg ctcggccgac gtggagagcg tggtgagcgg gaccctccgc     1020

tcagccttcg agtacggtgg ccagaagtgt tccgcctgct cgcgtctcta cgtgccgcac     1080

tcgctgtggc cgcagatcaa agggcggctg ctggaggagc acagtcggat caaagtgggc     1140

gaccctgcag aggattttgg gaccttcttc tctgcagtga ttgatgccaa gtcctttgcc     1200

cgtatcaaga agtggctgga gcacgcacgc tcctcaccca gcctcaccat cctggccggg     1260

ggcaagtgtg atgactccgt gggctacttt gtggagccct gcatcgtgga gagcaaggac     1320

cctcaggagc ccatcatgaa ggaggagatc ttcgggcctg tactgtctgt gtacgtctac     1380

ccggatgaca agtacaagga gacgctgcag ctgattgaca gcaccaccag ctatggcctc     1440

acgggggcag tgttctccca ggataaggac gtcgtgcagg aggccacaaa ggtgctgagg     1500

aatgctgccg gcaacttcta catcaacgac aagtccactg gctcgatagt gggccagcag     1560

ccctttgggg gggcccgagc ctctggaacc aatgacaagc cagggggccc acactacatc     1620

ctgcgctgga cgtcgccgca ggtcatcaag gagacacata agcccctggg ggactggagc     1680

tacgcgtaca tgcagtgagc ccctctcggg ctccaccgtc cagctgtctg tccgtccagg     1740

tggccgacct cactgcacag accccactcc agcccctcca ccccttcttc atgcacagct     1800

gcctttctat aatccgggct tgactccctt cttaccactg tattctggcc tctcccatgc     1860

ctcaggctct ggtttgagat cgtgctgggg aggaacatgg ccactacccc ttatcccatc     1920

ggccatgtgg gaggtatgac cctggtgcct ggcaggttct ccctctgccc tccactgggc     1980

ccagtggctc agggacctgg ggaaaggaga tggagcagct cttgggatcc tttggggaaa     2040

aggaggccat tctgggcccc ttggcaaacc tcaccactca cagaggctcc tggccttgat     2100

ccctgcccct ccaggtgtcc agggtaaagt gtaactcaga ctgacctgtg gggcacaggg     2160

ggcaccagct ggccttgccc tctctggtct gggctgtcta ccttcctcac tgtatctttg     2220

cccagaccca cctgggccag taggcccctg tccccagcca cacaccttag atgctggcat     2280

gccttactcc aggtgcctgt gtttggccga ggcctgtgtg attcccggtc tgcaccacat     2340

ggcggggttg gggggccgct ggaggccacc tgccaaggcg tgggatggga tggtcctgcc     2400

ggtttaggcc gtgattctgg aaaaccttgg atgggccttc gtcctatgtc agccttccct     2460

ttgatcctca ggccctacct gtagagacct ccactcctag agccagtctc agggtctggg     2520

atttccctgc aggagctcag ccaccactgt gccatggtga cacaggccaa ggcagacatt     2580

ggccctccct tctcccagcc cccagaggcc tggccttggg ttcgtcagca tgggccgagg     2640

acgttgcctg tagaatcctc ctctgcctgg gagtggctct gtgtggacca gtccctcact     2700

ggcccattct ttttttgacg cagccaatct gtgaccacga ttcctcccac agatgcctcc     2760

tgcttggatt ctgagtggtc agagatctgt aaagcatgac tttcaaggat ggttcttagg     2820

ggactgtgaa agtgttgggt cttcctccag gatgcctgca tgggacccca cccggagctg     2880

gtgtggccat tccccaagtg ccactggccc atggatgggg gtgggtgctg gtgccagctg     2940

ggctgggtgt gggttctgtg tccttccagg atatgtgtca tttcccatga ggggccgggg     3000

caggtggctg ggtgggggca caggctggag tattcttagt tctactggtt ctacactgtg     3060

aggtggcaat gggatttgct cagatgccac ccaataaaat gcctgttact taaaaaaaaa     3120

aaaaaaaaaa                                                            3130


<210>  632
<211>  563
<212>  PRT
<213>  Homo sapiens

<400>  632

Met Leu Leu Pro Ala Pro Ala Leu Arg Arg Ala Leu Leu Ser Arg Pro 
1               5                   10                  15      


Trp Thr Gly Ala Gly Leu Arg Trp Lys His Thr Ser Ser Leu Lys Val 
            20                  25                  30          


Ala Asn Glu Pro Val Leu Ala Phe Thr Gln Gly Ser Pro Glu Arg Asp 
        35                  40                  45              


Ala Leu Gln Lys Ala Leu Lys Asp Leu Lys Gly Arg Met Glu Ala Ile 
    50                  55                  60                  


Pro Cys Val Val Gly Asp Glu Glu Val Trp Thr Ser Asp Val Gln Tyr 
65                  70                  75                  80  


Gln Val Ser Pro Phe Asn His Gly His Lys Val Ala Lys Phe Cys Tyr 
                85                  90                  95      


Ala Asp Lys Ser Leu Leu Asn Lys Ala Ile Glu Ala Ala Leu Ala Ala 
            100                 105                 110         


Arg Lys Glu Trp Asp Leu Lys Pro Ile Ala Asp Arg Ala Gln Ile Phe 
        115                 120                 125             


Leu Lys Ala Ala Asp Met Leu Ser Gly Pro Arg Arg Ala Glu Ile Leu 
    130                 135                 140                 


Ala Lys Thr Met Val Gly Gln Gly Lys Thr Val Ile Gln Ala Glu Ile 
145                 150                 155                 160 


Asp Ala Ala Ala Glu Leu Ile Asp Phe Phe Arg Phe Asn Ala Lys Tyr 
                165                 170                 175     


Ala Val Glu Leu Glu Gly Gln Gln Pro Ile Ser Val Pro Pro Ser Thr 
            180                 185                 190         


Asn Ser Thr Val Tyr Arg Gly Leu Glu Gly Phe Val Ala Ala Ile Ser 
        195                 200                 205             


Pro Phe Asn Phe Thr Ala Ile Gly Gly Asn Leu Ala Gly Ala Pro Ala 
    210                 215                 220                 


Leu Met Gly Asn Val Val Leu Trp Lys Pro Ser Asp Thr Ala Met Leu 
225                 230                 235                 240 


Ala Ser Tyr Ala Val Tyr Arg Ile Leu Arg Glu Ala Gly Leu Pro Pro 
                245                 250                 255     


Asn Ile Ile Gln Phe Val Pro Ala Asp Gly Pro Leu Phe Gly Asp Thr 
            260                 265                 270         


Val Thr Ser Ser Glu His Leu Cys Gly Ile Asn Phe Thr Gly Ser Val 
        275                 280                 285             


Pro Thr Phe Lys His Leu Trp Lys Gln Val Ala Gln Asn Leu Asp Arg 
    290                 295                 300                 


Phe His Thr Phe Pro Arg Leu Ala Gly Glu Cys Gly Gly Lys Asn Phe 
305                 310                 315                 320 


His Phe Val His Arg Ser Ala Asp Val Glu Ser Val Val Ser Gly Thr 
                325                 330                 335     


Leu Arg Ser Ala Phe Glu Tyr Gly Gly Gln Lys Cys Ser Ala Cys Ser 
            340                 345                 350         


Arg Leu Tyr Val Pro His Ser Leu Trp Pro Gln Ile Lys Gly Arg Leu 
        355                 360                 365             


Leu Glu Glu His Ser Arg Ile Lys Val Gly Asp Pro Ala Glu Asp Phe 
    370                 375                 380                 


Gly Thr Phe Phe Ser Ala Val Ile Asp Ala Lys Ser Phe Ala Arg Ile 
385                 390                 395                 400 


Lys Lys Trp Leu Glu His Ala Arg Ser Ser Pro Ser Leu Thr Ile Leu 
                405                 410                 415     


Ala Gly Gly Lys Cys Asp Asp Ser Val Gly Tyr Phe Val Glu Pro Cys 
            420                 425                 430         


Ile Val Glu Ser Lys Asp Pro Gln Glu Pro Ile Met Lys Glu Glu Ile 
        435                 440                 445             


Phe Gly Pro Val Leu Ser Val Tyr Val Tyr Pro Asp Asp Lys Tyr Lys 
    450                 455                 460                 


Glu Thr Leu Gln Leu Val Asp Ser Thr Thr Ser Tyr Gly Leu Thr Gly 
465                 470                 475                 480 


Ala Val Phe Ser Gln Asp Lys Asp Val Val Gln Glu Ala Thr Lys Val 
                485                 490                 495     


Leu Arg Asn Ala Ala Gly Asn Phe Tyr Ile Asn Asp Lys Ser Thr Gly 
            500                 505                 510         


Ser Ile Val Gly Gln Gln Pro Phe Gly Gly Ala Arg Ala Ser Gly Thr 
        515                 520                 525             


Asn Asp Lys Pro Gly Gly Pro His Tyr Ile Leu Arg Trp Thr Ser Pro 
    530                 535                 540                 


Gln Val Ile Lys Glu Thr His Lys Pro Leu Gly Asp Trp Ser Tyr Ala 
545                 550                 555                 560 


Tyr Met Gln 
            


<210>  633
<211>  563
<212>  PRT
<213>  Homo sapiens

<400>  633

Met Leu Leu Pro Ala Pro Ala Leu Arg Arg Ala Leu Leu Ser Arg Pro 
1               5                   10                  15      


Trp Thr Gly Ala Gly Leu Arg Trp Lys His Thr Ser Ser Leu Lys Val 
            20                  25                  30          


Ala Asn Glu Pro Val Leu Ala Phe Thr Gln Gly Ser Pro Glu Arg Asp 
        35                  40                  45              


Ala Leu Gln Lys Ala Leu Lys Asp Leu Lys Gly Arg Met Glu Ala Ile 
    50                  55                  60                  


Pro Cys Val Val Gly Asp Glu Glu Val Trp Thr Ser Asp Val Gln Tyr 
65                  70                  75                  80  


Gln Val Ser Pro Phe Asn His Gly His Lys Val Ala Lys Phe Cys Tyr 
                85                  90                  95      


Ala Asp Lys Ser Leu Leu Asn Lys Ala Ile Glu Ala Ala Leu Ala Ala 
            100                 105                 110         


Arg Lys Glu Trp Asp Leu Lys Pro Ile Ala Asp Arg Ala Gln Ile Phe 
        115                 120                 125             


Leu Lys Ala Ala Asp Met Leu Ser Gly Pro Arg Arg Ala Glu Ile Leu 
    130                 135                 140                 


Ala Lys Thr Met Val Gly Gln Gly Lys Thr Val Ile Gln Ala Glu Ile 
145                 150                 155                 160 


Asp Ala Ala Ala Glu Leu Ile Asp Phe Phe Arg Phe Asn Ala Lys Tyr 
                165                 170                 175     


Ala Val Glu Leu Glu Gly Gln Gln Pro Ile Ser Val Pro Pro Ser Thr 
            180                 185                 190         


Asn Ser Thr Val Tyr Arg Gly Leu Glu Gly Phe Val Ala Ala Ile Ser 
        195                 200                 205             


Pro Phe Asn Phe Thr Ala Ile Gly Gly Asn Leu Ala Gly Ala Pro Ala 
    210                 215                 220                 


Leu Met Gly Asn Val Val Leu Trp Lys Pro Ser Asp Thr Ala Met Leu 
225                 230                 235                 240 


Ala Ser Tyr Ala Val Tyr Arg Ile Leu Arg Glu Ala Gly Leu Pro Pro 
                245                 250                 255     


Asn Ile Ile Gln Phe Val Pro Ala Asp Gly Pro Leu Phe Gly Asp Thr 
            260                 265                 270         


Val Thr Ser Ser Glu His Leu Cys Gly Ile Asn Phe Thr Gly Ser Val 
        275                 280                 285             


Pro Thr Phe Lys His Leu Trp Lys Gln Val Ala Gln Asn Leu Asp Arg 
    290                 295                 300                 


Phe His Thr Phe Pro Arg Leu Ala Gly Glu Cys Gly Gly Lys Asn Phe 
305                 310                 315                 320 


His Phe Val His Arg Ser Ala Asp Val Glu Ser Val Val Ser Gly Thr 
                325                 330                 335     


Leu Arg Ser Ala Phe Glu Tyr Gly Gly Gln Lys Cys Ser Ala Cys Ser 
            340                 345                 350         


Arg Leu Tyr Val Pro His Ser Leu Trp Pro Gln Ile Lys Gly Arg Leu 
        355                 360                 365             


Leu Glu Glu His Ser Arg Ile Lys Val Gly Asp Pro Ala Glu Asp Phe 
    370                 375                 380                 


Gly Thr Phe Phe Ser Ala Val Ile Asp Ala Lys Ser Phe Ala Arg Ile 
385                 390                 395                 400 


Lys Lys Trp Leu Glu His Ala Arg Ser Ser Pro Ser Leu Thr Ile Leu 
                405                 410                 415     


Ala Gly Gly Lys Cys Asp Asp Ser Val Gly Tyr Phe Val Glu Pro Cys 
            420                 425                 430         


Ile Val Glu Ser Lys Asp Pro Gln Glu Pro Ile Met Lys Glu Glu Ile 
        435                 440                 445             


Phe Gly Pro Val Leu Ser Val Tyr Val Tyr Pro Asp Asp Lys Tyr Lys 
    450                 455                 460                 


Glu Thr Leu Gln Leu Ile Asp Ser Thr Thr Ser Tyr Gly Leu Thr Gly 
465                 470                 475                 480 


Ala Val Phe Ser Gln Asp Lys Asp Val Val Gln Glu Ala Thr Lys Val 
                485                 490                 495     


Leu Arg Asn Ala Ala Gly Asn Phe Tyr Ile Asn Asp Lys Ser Thr Gly 
            500                 505                 510         


Ser Ile Val Gly Gln Gln Pro Phe Gly Gly Ala Arg Ala Ser Gly Thr 
        515                 520                 525             


Asn Asp Lys Pro Gly Gly Pro His Tyr Ile Leu Arg Trp Thr Ser Pro 
    530                 535                 540                 


Gln Val Ile Lys Glu Thr His Lys Pro Leu Gly Asp Trp Ser Tyr Ala 
545                 550                 555                 560 


Tyr Met Gln 
            


<210>  634
<211>  1979
<212>  DNA
<213>  Homo sapiens

<400>  634
ggaggccctg ggaccgcgga agaggcttca gacgctgcag cgatgcctcg cccacggcgg       60

atgcctttgg tgcttcatga agaatatttc cagatatctc acagacatta agcctttgcc      120

tcccaacaaa aagacagact gattaaaata atgagtatgc agggacagat aacagattca      180

aatataagtg agattttaca tcctgaagtc caaactctag atctacggag ctgcgatata      240

tcagatgctg ctctcctgca cctgtctaac tgtagaaaac tgaagaaatt aaatttaaat      300

gcttcaaaag ggaaccgagt ttctgtaact tcagaaggaa taaaagctgt ggcttcatct      360

tgttcatacc tacacgaagc ttctttgaaa agatgctgca atctcactga cgaaggagtc      420

gttgctcttg cactcaattg ccagctgcta aagatcatcg atttaggtgg ctgcttaagt      480

attactgatg tgtccttaca tgcattagga aaaaactgcc catttttgca gtgtgtcgac      540

ttttcagcta ctcaggtatc tgacagtggt gtgattgcac ttgttagtgg accttgtgcg      600

aagaaattag aggagattca tatgggacat tgtgtaaatc tgactgatgg ggctgtcgaa      660

gctgtcctta cttactgtcc tcaaatacgt atattactct tccatggatg ccccttgata      720

acagatcatt cccgagaagt gttggagcaa ttagtaggcc caaacaaact aaagcaagtg      780

acatggactg tttattgatg cttttttgaa gatgatcaat gctaggaaag cttatcaaaa      840

ctactttccc aggaaaccat ctatagagat ttgcattcta cttaatgtta acactatttt      900

taattatttt attgtgttaa gttataactc tcagagaatt agctaagtct tggtatatac      960

atggtttgtg ctttactctt aaacatcttt aaagtgctat tattctatat ctgttggatg     1020

agtcattatt tttgaaatga taatcctagc atgaactctg atctatggtg ttggattctg     1080

tttcttaaat aactttaaaa ttaactgttt tcccttgaga tttccttctc ctatgtaggt     1140

atttgagcta ttgttctaag tttacctgta agtataaacc ttgggagaat ctaagtaaac     1200

atatttctaa aagcatagtt accttcctat tttctggctc ttaccttctt ggagtattta     1260

aatgcccatt tgccaaaagc agacctgaac atcaagcctg ttaattcttc aaagaattta     1320

ggtatttgtt tcaccgaaat gaagtgactt attagccatt cagcgtatta gtattacaga     1380

ggctcttgct cagccacatc cattcattga tttttatggc tactcttccc agttacattt     1440

tatgcatctg taagctttcc ttccttagca aaattgcatt caaaaatgtg taaaaatgag     1500

taaatacaga atatcactac agagacttgt atcctcaggt ttattgattt cacattgtga     1560

aataaacagc aaaggtctta gttttcaagt gaaaactttt tggtaatcac aaaattacct     1620

gacacatacc acgcttaaac caacccccaa atttagcata ttcattttgc catgagccag     1680

tcttgagatt ttcttaaaag atttcttatt ttgcctctga tgtagtgaaa aacggggtaa     1740

gtatgctaac tttcttgtat atgttggggg gtacttattc aactccattt cttgtcctta     1800

caagatttat aaatgtggta tgtttatagt gtggatatat atgttgccac tgcaaaggtg     1860

gtgcatatgt atatatgtgc aaaatgggta aggcctgttc taactatgaa atttttctaa     1920

agacaaattc aataaaattt aatactgaat atttaaccaa gtcaaaaaaa aaaaaaaaa      1979


<210>  635
<211>  258
<212>  PRT
<213>  Homo sapiens

<400>  635

Met Pro Arg Pro Arg Arg Val Ser Gln Leu Leu Asp Leu Cys Leu Trp 
1               5                   10                  15      


Cys Phe Met Lys Asn Ile Ser Arg Tyr Leu Thr Asp Ile Lys Pro Leu 
            20                  25                  30          


Pro Pro Asn Ile Lys Asp Arg Leu Ile Lys Ile Met Ser Met Gln Gly 
        35                  40                  45              


Gln Ile Thr Asp Ser Asn Ile Ser Glu Ile Leu His Pro Glu Val Gln 
    50                  55                  60                  


Thr Leu Asp Leu Arg Ser Cys Asp Ile Ser Asp Ala Ala Leu Leu His 
65                  70                  75                  80  


Leu Ser Asn Cys Arg Lys Leu Lys Lys Leu Asn Leu Asn Ala Ser Lys 
                85                  90                  95      


Gly Asn Arg Val Ser Val Thr Ser Glu Gly Ile Lys Ala Val Ala Ser 
            100                 105                 110         


Ser Cys Ser Tyr Leu His Glu Ala Ser Leu Lys Arg Cys Cys Asn Leu 
        115                 120                 125             


Thr Asp Glu Gly Val Val Ala Leu Ala Leu Asn Cys Gln Leu Leu Lys 
    130                 135                 140                 


Ile Ile Asp Leu Gly Gly Cys Leu Ser Ile Thr Asp Val Ser Leu His 
145                 150                 155                 160 


Ala Leu Gly Lys Asn Cys Pro Phe Leu Gln Cys Val Asp Phe Ser Ala 
                165                 170                 175     


Thr Gln Val Ser Asp Ser Gly Val Ile Ala Leu Val Ser Gly Pro Cys 
            180                 185                 190         


Ala Lys Lys Leu Glu Glu Ile His Met Gly His Cys Val Asn Leu Thr 
        195                 200                 205             


Asp Gly Ala Val Glu Ala Val Leu Thr Tyr Cys Pro Gln Ile Arg Ile 
    210                 215                 220                 


Leu Leu Phe His Gly Cys Pro Leu Ile Thr Asp His Ser Arg Glu Val 
225                 230                 235                 240 


Leu Glu Gln Leu Val Gly Pro Asn Lys Leu Lys Gln Val Thr Trp Thr 
                245                 250                 255     


Val Tyr 
        


<210>  636
<211>  213
<212>  PRT
<213>  Homo sapiens

<400>  636

Met Gln Gly Gln Ile Thr Asp Ser Asn Ile Ser Glu Ile Leu His Pro 
1               5                   10                  15      


Glu Val Gln Thr Leu Asp Leu Arg Ser Cys Asp Ile Ser Asp Ala Ala 
            20                  25                  30          


Leu Leu His Leu Ser Asn Cys Arg Lys Leu Lys Lys Leu Asn Leu Asn 
        35                  40                  45              


Ala Ser Lys Gly Asn Arg Val Ser Val Thr Ser Glu Gly Ile Lys Ala 
    50                  55                  60                  


Val Ala Ser Ser Cys Ser Tyr Leu His Glu Ala Ser Leu Lys Arg Cys 
65                  70                  75                  80  


Cys Asn Leu Thr Asp Glu Gly Val Val Ala Leu Ala Leu Asn Cys Gln 
                85                  90                  95      


Leu Leu Lys Ile Ile Asp Leu Gly Gly Cys Leu Ser Ile Thr Asp Val 
            100                 105                 110         


Ser Leu His Ala Leu Gly Lys Asn Cys Pro Phe Leu Gln Cys Val Asp 
        115                 120                 125             


Phe Ser Ala Thr Gln Val Ser Asp Ser Gly Val Ile Ala Leu Val Ser 
    130                 135                 140                 


Gly Pro Cys Ala Lys Lys Leu Glu Glu Ile His Met Gly His Cys Val 
145                 150                 155                 160 


Asn Leu Thr Asp Gly Ala Val Glu Ala Val Leu Thr Tyr Cys Pro Gln 
                165                 170                 175     


Ile Arg Ile Leu Leu Phe His Gly Cys Pro Leu Ile Thr Asp His Ser 
            180                 185                 190         


Arg Glu Val Leu Glu Gln Leu Val Gly Pro Asn Lys Leu Lys Gln Val 
        195                 200                 205             


Thr Trp Thr Val Tyr 
    210             


<210>  637
<211>  1610
<212>  DNA
<213>  Homo sapiens

<400>  637
ccgcgccagt cgcctagcag gtcctctacc ggcttattcc tgtgccggat cttcatcggc       60

acaggggcca ctgagacgtt tctgcctccc tctttcttcc tccgctcttt ctcttccctc      120

tcgtttagtt tgcctggagc ttgaaaggag aaagcacggg gtcgccccaa accccttctg      180

cttctgccca tcacaagtgc cactaccgcc atgggcctca ctatctcctc cctcttctcc      240

cgactatttg gcaagaagca gatgcgcatt ttgatggttg gattggatgc tgctggcaag      300

acaaccattc tgtataaact gaagttaggg gagatagtca ccaccattcc taccattggt      360

tttaatgtgg aaacagtaga atataagaac atttgtttca cagtatggga tgttggtggt      420

caagatagaa ttaggcctct ctggaagcat tacttccaga atacccaggg tcttattttt      480

gtggtagata gcaacgatcg tgaaagaatt caggaagtag cagatgagct gcagaaaatg      540

cttctggtag atgaattgag agatgcagtg ctgctacttt ttgcaaacaa acaggatttg      600

ccaaatgcta tggccatcag tgaaatgaca gataaactag ggcttcagtc tcttcgtaac      660

agaacatggt atgttcaagc cacttgtgca acacaaggaa ctggtctgta tgaaggactt      720

gactggctgt caaatgagct ttcaaaacgt taaatgaaat tggatatcta accaaggaca      780

tgtttgataa aattggtcta ggcttgttac aacaaaatta gtttgtatct tggttattaa      840

acagtatctg ggactggttt gggcagaata ttaaacttat tttgttgcca attattgttt      900

accgagtata atgttgctat ttagcaatgt gcttggtttt aaagaaattc tccttgggaa      960

aaaagtatcc tcttttaatt ttacttccca taagcgtaaa tgcctggaca tagctcttgt     1020

gaacctttaa ataaattgtt tgagtgtttt tgagccccag acaaataatg ttttaaagtt     1080

atcccttgct actttactga tacctttatc attcctgaga cagtttgcta atttaaaaat     1140

gtagcattcc atttgtattt atttctctcc cttgccaaaa agattttcta atactgcttg     1200

taccagccag agaaagatcc aaaacactac tcagctctct tgcactgagg aaatttttcc     1260

ccctacattg actcctggcc tacatcagcc aaacttaacc ttggtggggt ttggatttga     1320

tagccaatta gttctgtgct ggttgcaaag aattgatatt tagatggttt ttaatactca     1380

gcagattgtc ttcccatatt gtgtcttttt tatgttgcat gttgcttttg ttatcagcct     1440

gattttttgc tcagtatatg atagttctgc tgatgttttg tttattgggc agacatatct     1500

tcattaagag tttttggaaa actcatcaaa ttcgatgaat acattttctt cataacccat     1560

ttggaattat tcctaataaa atgataaaat acgtaaaaaa aaaggaattc                1610


<210>  638
<211>  180
<212>  PRT
<213>  Homo sapiens

<400>  638

Met Gly Leu Thr Ile Ser Ser Leu Phe Ser Arg Leu Phe Gly Lys Lys 
1               5                   10                  15      


Gln Met Arg Ile Leu Met Val Gly Leu Asp Ala Ala Gly Lys Thr Thr 
            20                  25                  30          


Ile Leu Tyr Lys Leu Lys Leu Gly Glu Ile Val Thr Thr Ile Pro Thr 
        35                  40                  45              


Ile Gly Phe Asn Val Glu Thr Val Glu Tyr Lys Asn Ile Cys Phe Thr 
    50                  55                  60                  


Val Trp Asp Val Gly Gly Gln Asp Arg Ile Arg Pro Leu Trp Lys His 
65                  70                  75                  80  


Tyr Phe Gln Asn Thr Gln Gly Leu Ile Phe Val Val Asp Ser Asn Asp 
                85                  90                  95      


Arg Glu Arg Ile Gln Glu Val Ala Asp Glu Leu Gln Lys Met Leu Leu 
            100                 105                 110         


Val Asp Glu Leu Arg Asp Ala Val Leu Leu Leu Phe Ala Asn Lys Gln 
        115                 120                 125             


Asp Leu Pro Asn Ala Met Ala Ile Ser Glu Met Thr Asp Lys Leu Gly 
    130                 135                 140                 


Leu Gln Ser Leu Arg Asn Arg Thr Trp Tyr Val Gln Ala Thr Cys Ala 
145                 150                 155                 160 


Thr Gln Gly Thr Gly Leu Tyr Glu Gly Leu Asp Trp Leu Ser Asn Glu 
                165                 170                 175     


Leu Ser Lys Arg 
            180 


<210>  639
<211>  180
<212>  PRT
<213>  Homo sapiens

<400>  639

Met Gly Leu Thr Ile Ser Ser Leu Phe Ser Arg Leu Phe Gly Lys Lys 
1               5                   10                  15      


Gln Met Arg Ile Leu Met Val Gly Leu Asp Ala Ala Gly Lys Thr Thr 
            20                  25                  30          


Ile Leu Tyr Lys Leu Lys Leu Gly Glu Ile Val Thr Thr Ile Pro Thr 
        35                  40                  45              


Ile Gly Phe Asn Val Glu Thr Val Glu Tyr Lys Asn Ile Cys Phe Thr 
    50                  55                  60                  


Val Trp Asp Val Gly Gly Gln Asp Arg Ile Arg Pro Leu Trp Lys His 
65                  70                  75                  80  


Tyr Phe Gln Asn Thr Gln Gly Leu Ile Phe Val Val Asp Ser Asn Asp 
                85                  90                  95      


Arg Glu Arg Ile Gln Glu Val Ala Asp Glu Leu Gln Lys Met Leu Leu 
            100                 105                 110         


Val Asp Glu Leu Arg Asp Ala Val Leu Leu Leu Phe Ala Asn Lys Gln 
        115                 120                 125             


Asp Leu Pro Asn Ala Met Ala Ile Ser Glu Met Thr Asp Lys Leu Gly 
    130                 135                 140                 


Leu Gln Ser Leu Arg Asn Arg Thr Trp Tyr Val Gln Ala Thr Cys Ala 
145                 150                 155                 160 


Thr Gln Gly Thr Gly Leu Tyr Glu Gly Leu Asp Trp Leu Ser Asn Glu 
                165                 170                 175     


Leu Ser Lys Arg 
            180 


<210>  640
<211>  1556
<212>  DNA
<213>  Homo sapiens

<400>  640
gactcactgt caacaacatc ccatcctgaa gacttgctta ccacaactga gagtggggag       60

tcagtttgag gcctagcatc acttaaactt cctccaaagg cacaaaagcc agaagagaaa      120

aatgaagacg ggacattttg aaatagtcac catgctgctg gcaaccatga ttctagtgga      180

cattttccag gtgaaggctg aagtgttaga catggcagat aatgcatttg atgatgaata      240

cctgaaatgt acggacagga tggaaattaa atacgttccc caactgctaa aggaggaaaa      300

agcaagccac cagcaattag atactgtgtg ggaaaatgca aaagccaaat gggcagcccg      360

aaagactcaa atctttctcc ctatgaattt taaggataac catggaatag ccctgatggc      420

atatatttcc gaagctcaag agcaaactcc cttttaccat ctgttcagtg aagctgtgaa      480

gatggctggc caatctcgag aagattatat ctatggcttc cagttcaaag ctttccactt      540

ttacctcaca agagccctgc agttgctgag aaaaccttgt gaggccagtt ccaaaactgt      600

ggtatataga acaagccagg gcacttcatt tacatttgga gggctaaacc aagccaggtt      660

tggccatttt accttggcat attcagccaa acctcaggct gctaatgacc agctcactgt      720

gttatccatc tacacatgcc ttggagttga cattgaaaat tttcttgata aagaaagtga      780

aagaattact ttaatacctc tgaatgaggt ttttcaagtg tcacaggagg gggctggcaa      840

taaccttatc cttcaaagca taaacaagac ctgcagccat tatgagtgtg catttctagg      900

tggactaaaa accgaaaact gtattgagaa cctagaatat tttcaaccca tctatgtcta      960

caaccctggt gagaaaaacc agaagcttga agaccatagt gagaaaaact ggaagcttga     1020

agaccatggt gagaaaaacc agaagcttga agaccatggt gtgaaaatcc ttgaacccac     1080

ccaaatacct gaagataaaa gtcaaggaaa tatcaacaat cctactccag gtccagttcc     1140

tgttccaggt cccaaaagcc atccttctgc atcctcgggc aaactgctgc ttccacagtt     1200

tgggatggtc atcattttaa tcagtgtttc tgctataaat ctctttgttg ctctgtagtt     1260

tgatgcattg tttatctttc ttattcttta cttgaaataa ctatagggat ccacaggaga     1320

tcaaaaggaa tgatgtattt tttacgtgtt ggccaaagtc actggataaa atgagaattg     1380

tatatttgtt attcattttg caaattcaga aagttggtcc agatatatgt cacagaactt     1440

ttcacttgta tactactctt acaatggaaa aaaatcccga aaactgtata cttctgatta     1500

aattcaataa aagattttga ttaggtaaaa aaaaaaaaaa aaaaaaaaaa aaaaaa         1556


<210>  641
<211>  389
<212>  PRT
<213>  Homo sapiens

<400>  641

Met Lys Thr Gly His Phe Glu Ile Val Thr Met Leu Leu Ala Thr Met 
1               5                   10                  15      


Ile Leu Val Asp Ile Phe Gln Val Lys Ala Glu Val Leu Asp Met Ala 
            20                  25                  30          


Asp Asn Ala Phe Asp Asp Glu Tyr Leu Lys Cys Thr Asp Arg Met Glu 
        35                  40                  45              


Ile Lys Tyr Val Pro Gln Leu Leu Lys Glu Glu Lys Ala Ser His Gln 
    50                  55                  60                  


Gln Leu Asp Thr Val Trp Glu Asn Ala Lys Ala Lys Trp Ala Ala Arg 
65                  70                  75                  80  


Lys Thr Gln Ile Phe Leu Pro Met Asn Phe Lys Asp Asn His Gly Ile 
                85                  90                  95      


Ala Leu Met Ala Tyr Ile Ser Glu Ala Gln Glu Gln Thr Pro Phe Tyr 
            100                 105                 110         


His Leu Phe Ser Glu Ala Val Lys Met Ala Gly Gln Ser Arg Glu Asp 
        115                 120                 125             


Tyr Ile Tyr Gly Phe Gln Phe Lys Ala Phe His Phe Tyr Leu Thr Arg 
    130                 135                 140                 


Ala Leu Gln Leu Leu Arg Lys Pro Cys Glu Ala Ser Ser Lys Thr Val 
145                 150                 155                 160 


Val Tyr Arg Thr Ser Gln Gly Thr Ser Phe Thr Phe Gly Gly Leu Asn 
                165                 170                 175     


Gln Ala Arg Phe Gly His Phe Thr Leu Ala Tyr Ser Ala Lys Pro Gln 
            180                 185                 190         


Ala Ala Asn Asp Gln Leu Thr Val Leu Ser Ile Tyr Thr Cys Leu Gly 
        195                 200                 205             


Val Asp Ile Glu Asn Phe Leu Asp Lys Glu Ser Glu Arg Ile Thr Leu 
    210                 215                 220                 


Ile Pro Leu Asn Glu Val Phe Gln Val Ser Gln Glu Gly Ala Gly Asn 
225                 230                 235                 240 


Asn Leu Ile Leu Gln Ser Ile Asn Lys Thr Cys Ser His Tyr Glu Cys 
                245                 250                 255     


Ala Phe Leu Gly Gly Leu Lys Thr Glu Asn Cys Ile Glu Asn Leu Glu 
            260                 265                 270         


Tyr Phe Gln Pro Ile Tyr Val Tyr Asn Pro Gly Glu Lys Asn Gln Lys 
        275                 280                 285             


Leu Glu Asp His Ser Glu Lys Asn Trp Lys Leu Glu Asp His Gly Glu 
    290                 295                 300                 


Lys Asn Gln Lys Leu Glu Asp His Gly Val Lys Ile Leu Glu Pro Thr 
305                 310                 315                 320 


Gln Ile Pro Gly Met Lys Ile Pro Glu Pro Phe Pro Leu Pro Glu Asp 
                325                 330                 335     


Lys Ser Gln Gly Asn Ile Asn Asn Pro Thr Pro Gly Pro Val Pro Val 
            340                 345                 350         


Pro Gly Pro Lys Ser His Pro Ser Ala Ser Ser Gly Lys Leu Leu Leu 
        355                 360                 365             


Pro Gln Phe Gly Met Val Ile Ile Leu Ile Ser Val Ser Ala Ile Asn 
    370                 375                 380                 


Leu Phe Val Ala Leu 
385                 


<210>  642
<211>  378
<212>  PRT
<213>  Homo sapiens

<400>  642

Met Lys Thr Gly His Phe Glu Ile Val Thr Met Leu Leu Ala Thr Met 
1               5                   10                  15      


Ile Leu Val Asp Ile Phe Gln Val Lys Ala Glu Val Leu Asp Met Ala 
            20                  25                  30          


Asp Asn Ala Phe Asp Asp Glu Tyr Leu Lys Cys Thr Asp Arg Met Glu 
        35                  40                  45              


Ile Lys Tyr Val Pro Gln Leu Leu Lys Glu Glu Lys Ala Ser His Gln 
    50                  55                  60                  


Gln Leu Asp Thr Val Trp Glu Asn Ala Lys Ala Lys Trp Ala Ala Arg 
65                  70                  75                  80  


Lys Thr Gln Ile Phe Leu Pro Met Asn Phe Lys Asp Asn His Gly Ile 
                85                  90                  95      


Ala Leu Met Ala Tyr Ile Ser Glu Ala Gln Glu Gln Thr Pro Phe Tyr 
            100                 105                 110         


His Leu Phe Ser Glu Ala Val Lys Met Ala Gly Gln Ser Arg Glu Asp 
        115                 120                 125             


Tyr Ile Tyr Gly Phe Gln Phe Lys Ala Phe His Phe Tyr Leu Thr Arg 
    130                 135                 140                 


Ala Leu Gln Leu Leu Arg Lys Pro Cys Glu Ala Ser Ser Lys Thr Val 
145                 150                 155                 160 


Val Tyr Arg Thr Ser Gln Gly Thr Ser Phe Thr Phe Gly Gly Leu Asn 
                165                 170                 175     


Gln Ala Arg Phe Gly His Phe Thr Leu Ala Tyr Ser Ala Lys Pro Gln 
            180                 185                 190         


Ala Ala Asn Asp Gln Leu Thr Val Leu Ser Ile Tyr Thr Cys Leu Gly 
        195                 200                 205             


Val Asp Ile Glu Asn Phe Leu Asp Lys Glu Ser Glu Arg Ile Thr Leu 
    210                 215                 220                 


Ile Pro Leu Asn Glu Val Phe Gln Val Ser Gln Glu Gly Ala Gly Asn 
225                 230                 235                 240 


Asn Leu Ile Leu Gln Ser Ile Asn Lys Thr Cys Ser His Tyr Glu Cys 
                245                 250                 255     


Ala Phe Leu Gly Gly Leu Lys Thr Glu Asn Cys Ile Glu Asn Leu Glu 
            260                 265                 270         


Tyr Phe Gln Pro Ile Tyr Val Tyr Asn Pro Gly Glu Lys Asn Gln Lys 
        275                 280                 285             


Leu Glu Asp His Ser Glu Lys Asn Trp Lys Leu Glu Asp His Gly Glu 
    290                 295                 300                 


Lys Asn Gln Lys Leu Glu Asp His Gly Val Lys Ile Leu Glu Pro Thr 
305                 310                 315                 320 


Gln Ile Pro Glu Asp Lys Ser Gln Gly Asn Ile Asn Asn Pro Thr Pro 
                325                 330                 335     


Gly Pro Val Pro Val Pro Gly Pro Lys Ser His Pro Ser Ala Ser Ser 
            340                 345                 350         


Gly Lys Leu Leu Leu Pro Gln Phe Gly Met Val Ile Ile Leu Ile Ser 
        355                 360                 365             


Val Ser Ala Ile Asn Leu Phe Val Ala Leu 
    370                 375             


<210>  643
<211>  2742
<212>  DNA
<213>  Homo sapiens

<400>  643
aggttactat agtgtctgct cctacccctg ggacaagatc ccctaatgag ctggcaggtg       60

ggcgtggggg gcacaggtac agcttggctt ctcagctttg ctcccctatc ctctgctttg      120

ccatgaatct ctcatccagc cccgcaggga tctgcctggc cagcagtgag cctgagcccc      180

tttcatcctg ggacctgccg accacggctc acatcctcct gggtgaagaa tgtcaccttg      240

cttcctatct gcctctttcg tggttggctg gggaggggga ccggggggtg gggtgaggtt      300

aacctcattg ttgtcttata tggtcattta aatctcccag ggcttcctcc aagggccaaa      360

aataatccgg agacacagca gctgtgtcca gcacacagag gacccggcca tctgctttgg      420

ttcagagccc tgtgtctgtc agtcagtctc tccctggctc tccctccatc ctcattcctg      480

cctgaagcca tgacccgctt ctcctatgca gagtactttt ccctctttca ctcctgctct      540

gcaccctcca ggtccactgc acctcctgag agttcgccgg cccgggcccc aatgggcttg      600

ttccaagggg tcatgcagaa atacagcagc agcttgttca agacctccca gctggcgcct      660

gcggacccct tgataaaggc catcaaggat ggcgatgaag aggccttgaa gaccatgatc      720

aaggaaggga agaatctcgc agagcccaac aaggagggct ggctgccgct gcacgaggcc      780

gcatactatg gccaggtggg ctgcctgaaa gtcctgcagc gagcgtaccc agggaccatc      840

gaccagcgca ccctgcagga ggaaacagcc gtttacttgg caacgtgcag gggccacctg      900

gactgtctcc tgtcactgct ccaagcaggg gcagagccgg acatctccaa caaatcccga      960

gagacaccgc tctacaaagc ctgcgagcgc aagaacgcgg aggccgtgaa gattctggtg     1020

cagcacaacg cagacaccaa ccaccgctgc aaccgcggct ggaccgctct gcacgagtct     1080

gtgtctcgca atgacctgga ggtcatgcag atcctggtga gcggaggagc caaggtggaa     1140

tccaagaacg cctacggcat cacccccttg ttcgtggccg cccagagtgg acagttggag     1200

gccttgaggt tcttagccaa gtacggtgct gacatcaaca cgcaggccag cgacaacgcg     1260

tctgccctct acgaggcctg caagaatgag catgaggagg tggtggagtt tctgctgtca     1320

cagggtgccg acgccaacaa gaccaacaag gacggcttgc tcccgctgca catcgcctcc     1380

aagaagggca actacaggat cgtgcagatg ctgctgccgg tgaccagccg cacgcgcata     1440

cgccgtagcg gcgtcagtcc gctgcacctg gcggccgagc gcaaccacga cgaggtgctg     1500

gaggcgctgc tgagcgcgcg cttcgacgtg aacacgccgc tggcgcccga gcgcgcgcgc     1560

ctctacgaag accggcgcag ctccgcgctg tacttcgcgg tggtcaacaa caacgtgtac     1620

gccaccgagc tgctgctgca acacggcgcc gaccccaacc gcgacgtcat cagccccttg     1680

ctcgtggcca tccgccacgg ctgcctgcgc acaatgcagc tgctgctgga ccacggcgcg     1740

aacatcgacg cctatatcgc cacgcacccc accgccttcc ccgccaccat catgttcgcc     1800

atgaagtgcc tgtcgctgct caagttcctc atggacctgg gctgcgacgg cgagccctgc     1860

ttctcatgcc tctacggcaa cggcccgcac ccgccggccc cgcagccctc cagcaggttc     1920

aacgacgcgc ccgcggccga caaggagccc agcgtggtgc agttctgtga gttcgtatct     1980

gccccagagg tgagccgctg ggcggggccc atcatcgatg tcctcctgga ctacgtgggc     2040

aacgtgcagc tctgctcgcg gctgaaggaa cacatcgaca gctttgagga ctgggccgtc     2100

atcaaggaga aggcagaacc tccaagacct ctggctcacc tttgccgact gcgggttcga     2160

aaggccattg ggaaataccg tataaaactc ctagacacct tgccgctccc aggcaggctg     2220

attagatacc tgaaatacga gaacacccag taactggggc cacggggaga gaggagtagc     2280

ccctcagact cttcttacta agtctcagga cgtcggtgtt cccaactcca aggggacctg     2340

gtgacagacg aggctgcagg ctgcctccct ctcagcctgg acagctacca ggatctcact     2400

gggtctcagg gcccagagct ttggccagag cagagaacag aatgtgtcaa ggagaagaat     2460

catttgttta caaactgatg agcagatccc agaccttctc taccttcagg aatggcagaa     2520

acctctattc ctggggccag ggcagagctt gaggtgttct ggggaaggtg gtgctcagag     2580

ccttccctgt gcccctccac ttgttctgga aaactcacca cttgacttca gagctttctc     2640

tccaaagact aagatgaaga cgtggcccaa ggtagggggt agggggagcc tgggtcttgg     2700

agggctttgt taagtattaa tataataaat gttacacatg tg                        2742


<210>  644
<211>  587
<212>  PRT
<213>  Homo sapiens

<400>  644

Met Thr Arg Phe Ser Tyr Ala Glu Tyr Phe Ser Leu Phe His Ser Cys 
1               5                   10                  15      


Ser Ala Pro Ser Arg Ser Thr Ala Pro Pro Glu Ser Ser Pro Ala Arg 
            20                  25                  30          


Ala Pro Met Gly Leu Phe Gln Gly Val Met Gln Lys Tyr Ser Ser Ser 
        35                  40                  45              


Leu Phe Lys Thr Ser Gln Leu Ala Pro Ala Asp Pro Leu Ile Lys Ala 
    50                  55                  60                  


Ile Lys Asp Gly Asp Glu Glu Ala Leu Lys Thr Met Ile Lys Glu Gly 
65                  70                  75                  80  


Lys Asn Leu Ala Glu Pro Asn Lys Glu Gly Trp Leu Pro Leu His Glu 
                85                  90                  95      


Ala Ala Tyr Tyr Gly Gln Val Gly Cys Leu Lys Val Leu Gln Arg Ala 
            100                 105                 110         


Tyr Pro Gly Thr Ile Asp Gln Arg Thr Leu Gln Glu Glu Thr Ala Val 
        115                 120                 125             


Tyr Leu Ala Thr Cys Arg Gly His Leu Asp Cys Leu Leu Ser Leu Leu 
    130                 135                 140                 


Gln Ala Gly Ala Glu Pro Asp Ile Ser Asn Lys Ser Arg Glu Thr Pro 
145                 150                 155                 160 


Leu Tyr Lys Ala Cys Glu Arg Lys Asn Ala Glu Ala Val Lys Ile Leu 
                165                 170                 175     


Val Gln His Asn Ala Asp Thr Asn His Arg Cys Asn Arg Gly Trp Thr 
            180                 185                 190         


Ala Leu His Glu Ser Val Ser Arg Asn Asp Leu Glu Val Met Gln Ile 
        195                 200                 205             


Leu Val Ser Gly Gly Ala Lys Val Glu Ser Lys Asn Ala Tyr Gly Ile 
    210                 215                 220                 


Thr Pro Leu Phe Val Ala Ala Gln Ser Gly Gln Leu Glu Ala Leu Arg 
225                 230                 235                 240 


Phe Leu Ala Lys Tyr Gly Ala Asp Ile Asn Thr Gln Ala Ser Asp Asn 
                245                 250                 255     


Ala Ser Ala Leu Tyr Glu Ala Cys Lys Asn Glu His Glu Glu Val Val 
            260                 265                 270         


Glu Phe Leu Leu Ser Gln Gly Ala Asp Ala Asn Lys Thr Asn Lys Asp 
        275                 280                 285             


Gly Leu Leu Pro Leu His Ile Ala Ser Lys Lys Gly Asn Tyr Arg Ile 
    290                 295                 300                 


Val Gln Met Leu Leu Pro Val Thr Ser Arg Thr Arg Ile Arg Arg Ser 
305                 310                 315                 320 


Gly Val Ser Pro Leu His Leu Ala Ala Glu Arg Asn His Asp Glu Val 
                325                 330                 335     


Leu Glu Ala Leu Leu Ser Ala Arg Phe Asp Val Asn Thr Pro Leu Ala 
            340                 345                 350         


Pro Glu Arg Ala Arg Leu Tyr Glu Asp Arg Arg Ser Ser Ala Leu Tyr 
        355                 360                 365             


Phe Ala Val Val Asn Asn Asn Val Tyr Ala Thr Glu Leu Leu Leu Gln 
    370                 375                 380                 


His Gly Ala Asp Pro Asn Arg Asp Val Ile Ser Pro Leu Leu Val Ala 
385                 390                 395                 400 


Ile Arg His Gly Cys Leu Arg Thr Met Gln Leu Leu Leu Asp His Gly 
                405                 410                 415     


Ala Asn Ile Asp Ala Tyr Ile Ala Thr His Pro Thr Ala Phe Pro Ala 
            420                 425                 430         


Thr Ile Met Phe Ala Met Lys Cys Leu Ser Leu Leu Lys Phe Leu Met 
        435                 440                 445             


Asp Leu Gly Cys Asp Gly Glu Pro Cys Phe Ser Cys Leu Tyr Gly Asn 
    450                 455                 460                 


Gly Pro His Pro Pro Ala Pro Gln Pro Ser Ser Arg Phe Asn Asp Ala 
465                 470                 475                 480 


Pro Ala Ala Asp Lys Glu Pro Ser Val Val Gln Phe Cys Glu Phe Val 
                485                 490                 495     


Ser Ala Pro Glu Val Ser Arg Trp Ala Gly Pro Ile Ile Asp Val Leu 
            500                 505                 510         


Leu Asp Tyr Val Gly Asn Val Gln Leu Cys Ser Arg Leu Lys Glu His 
        515                 520                 525             


Ile Asp Ser Phe Glu Asp Trp Ala Val Ile Lys Glu Lys Ala Glu Pro 
    530                 535                 540                 


Pro Arg Pro Leu Ala His Leu Cys Arg Leu Arg Val Arg Lys Ala Ile 
545                 550                 555                 560 


Gly Lys Tyr Arg Ile Lys Leu Leu Asp Thr Leu Pro Leu Pro Gly Arg 
                565                 570                 575     


Leu Ile Arg Tyr Leu Lys Tyr Glu Asn Thr Gln 
            580                 585         


<210>  645
<211>  587
<212>  PRT
<213>  Homo sapiens

<400>  645

Met Thr Arg Phe Ser Tyr Ala Glu Tyr Phe Ser Leu Phe His Ser Cys 
1               5                   10                  15      


Ser Ala Pro Ser Arg Ser Thr Ala Pro Pro Glu Ser Ser Pro Ala Arg 
            20                  25                  30          


Ala Pro Met Gly Leu Phe Gln Gly Val Met Gln Lys Tyr Ser Ser Ser 
        35                  40                  45              


Leu Phe Lys Thr Ser Gln Leu Ala Pro Ala Asp Pro Leu Ile Lys Ala 
    50                  55                  60                  


Ile Lys Asp Gly Asp Glu Glu Ala Leu Lys Thr Met Ile Lys Glu Gly 
65                  70                  75                  80  


Lys Asn Leu Ala Glu Pro Asn Lys Glu Gly Trp Leu Pro Leu His Glu 
                85                  90                  95      


Ala Ala Tyr Tyr Gly Gln Val Gly Cys Leu Lys Val Leu Gln Arg Ala 
            100                 105                 110         


Tyr Pro Gly Thr Ile Asp Gln Arg Thr Leu Gln Glu Glu Thr Ala Val 
        115                 120                 125             


Tyr Leu Ala Thr Cys Arg Gly His Leu Asp Cys Leu Leu Ser Leu Leu 
    130                 135                 140                 


Gln Ala Gly Ala Glu Pro Asp Ile Ser Asn Lys Ser Arg Glu Thr Pro 
145                 150                 155                 160 


Leu Tyr Lys Ala Cys Glu Arg Lys Asn Ala Glu Ala Val Lys Ile Leu 
                165                 170                 175     


Val Gln His Asn Ala Asp Thr Asn His Arg Cys Asn Arg Gly Trp Thr 
            180                 185                 190         


Ala Leu His Glu Ser Val Ser Arg Asn Asp Leu Glu Val Met Gln Ile 
        195                 200                 205             


Leu Val Ser Gly Gly Ala Lys Val Glu Ser Lys Asn Ala Tyr Gly Ile 
    210                 215                 220                 


Thr Pro Leu Phe Val Ala Ala Gln Ser Gly Gln Leu Glu Ala Leu Arg 
225                 230                 235                 240 


Phe Leu Ala Lys Tyr Gly Ala Asp Ile Asn Thr Gln Ala Ser Asp Asn 
                245                 250                 255     


Ala Ser Ala Leu Tyr Glu Ala Cys Lys Asn Glu His Glu Glu Val Val 
            260                 265                 270         


Glu Phe Leu Leu Ser Gln Gly Ala Asp Ala Asn Lys Thr Asn Lys Asp 
        275                 280                 285             


Gly Leu Leu Pro Leu His Ile Ala Ser Lys Lys Gly Asn Tyr Arg Ile 
    290                 295                 300                 


Val Gln Met Leu Leu Pro Val Thr Ser Arg Thr Arg Ile Arg Arg Ser 
305                 310                 315                 320 


Gly Val Ser Pro Leu His Leu Ala Ala Glu Arg Asn His Asp Glu Val 
                325                 330                 335     


Leu Glu Ala Leu Leu Ser Ala Arg Phe Asp Val Asn Thr Pro Leu Ala 
            340                 345                 350         


Pro Glu Arg Ala Arg Leu Tyr Glu Asp Arg Arg Ser Ser Ala Leu Tyr 
        355                 360                 365             


Phe Ala Val Val Asn Asn Asn Val Tyr Ala Thr Glu Leu Leu Leu Gln 
    370                 375                 380                 


His Gly Ala Asp Pro Asn Arg Asp Val Ile Ser Pro Leu Leu Val Ala 
385                 390                 395                 400 


Ile Arg His Gly Cys Leu Arg Thr Met Gln Leu Leu Leu Asp His Gly 
                405                 410                 415     


Ala Asn Ile Asp Ala Tyr Ile Ala Thr His Pro Thr Ala Phe Pro Ala 
            420                 425                 430         


Thr Ile Met Phe Ala Met Lys Cys Leu Ser Leu Leu Lys Phe Leu Met 
        435                 440                 445             


Asp Leu Gly Cys Asp Gly Glu Pro Cys Phe Ser Cys Leu Tyr Gly Asn 
    450                 455                 460                 


Gly Pro His Pro Pro Ala Pro Gln Pro Ser Ser Arg Phe Asn Asp Ala 
465                 470                 475                 480 


Pro Ala Ala Asp Lys Glu Pro Ser Val Val Gln Phe Cys Glu Phe Val 
                485                 490                 495     


Ser Ala Pro Glu Val Ser Arg Trp Ala Gly Pro Ile Ile Asp Val Leu 
            500                 505                 510         


Leu Asp Tyr Val Gly Asn Val Gln Leu Cys Ser Arg Leu Lys Glu His 
        515                 520                 525             


Ile Asp Ser Phe Glu Asp Trp Ala Val Ile Lys Glu Lys Ala Glu Pro 
    530                 535                 540                 


Pro Arg Pro Leu Ala His Leu Cys Arg Leu Arg Val Arg Lys Ala Ile 
545                 550                 555                 560 


Gly Lys Tyr Arg Ile Lys Leu Leu Asp Thr Leu Pro Leu Pro Gly Arg 
                565                 570                 575     


Leu Ile Arg Tyr Leu Lys Tyr Glu Asn Thr Gln 
            580                 585         


<210>  646
<211>  1625
<212>  DNA
<213>  Homo sapiens

<400>  646
gtagcactca gattaccctg cctgctctgt gctttgctgc agaccatttg accagaacgt       60

gtgcagctca gccagccaca gaactggaat ttttcaggag cagggggagc atggagtttg      120

gactttgctg agcaactgaa gtggagcgca gagcttgctc gcttaggaga gagcatcatg      180

gatggcaaac aagggggcat ggatgggagc aagcccgcgg ggccaaggga ctttcctggc      240

atcaggcttc tttcaaaccc attgatgggc gatgctgtgt ctgattggtc tcctatgcat      300

gaagctgcaa tccacggaca tcagctgtct ctgaggaacc tcatcagcca ggggtgggct      360

gtgaacatca tcacggcaga tcatgtttcc ccactccatg aagcctgtct tggaggtcat      420

ctctcttgtg tgaagatttt attaaagcat ggagctcagg tgaatggtgt gacagcagac      480

tggcacactc cactgtttaa tgcttgtgtc agcggcagct gggattgtgt gaatttgctt      540

ctgcagcacg gagccagcgt tcaacctgag agtgatctgg catcccccat ccatgaagct      600

gctaggagag cttatggggg caacattgac cataagatca gccacctggg cactccactc      660

tatttggctt gtgaaaacca acagagagcc tgtgtcaaga agcttctgga gtcaggagcg      720

gacgtgaacc aagggaaagg tcaggattcc ccacttcatg cagtggccag gacagccagt      780

gaagagctgg cctgcctgct catggatttt ggagcggaca cccaggccaa gaatgctgaa      840

ggcaaacgtc ctgtggagct ggtgcctcca gagagcccct tggcccagct cttcttggag      900

agagaaggtg cttctttgcc aaaacctaag ccctaatctg ttgacatccc ttggggctct      960

agtagaaggg cccccttctt tgatgcagtt atgccgcctt agaattcgga agtgttttgg     1020

aatccagcag catcataaga taaccaaact cgtcctccca gaggatctga aacagtttct     1080

cctacatctt taaatgcatc tagggaatgg attcacaaac gatgtgaaaa cattattgag     1140

tgttgtagcc actagaattt taaaatcaag ttggatttat agagtttgac tagttttttc     1200

gattagattt gtatttgtta taaacttgtt tatggagttt gactaatttt ttctattcaa     1260

tttgtatttg ttaaactcaa gccagggttg aaagacactg catacgtttg tattattagt     1320

tagaaggcat gaagactttt ttccctgcat ggagagtgtc ataagttatt gttttgcata     1380

tctactgcat gccaagcact ttctgcatca tctaatttag ccctcacagc cactgggtca     1440

agatgtccaa ttttccagag taaggataga ggagtcaaat tcaaatacag gttttctgac     1500

attaacttat gtgatgactt gatcgaggca ggcttttcca gcatcactgt cctggttcca     1560

tctctgctat atgggaatga aaataaagaa acatatttct tggcttgtct aaaaaaaaaa     1620

aaaaa                                                                 1625


<210>  647
<211>  294
<212>  PRT
<213>  Homo sapiens

<400>  647

Met Asp Gly Lys Gln Gly Gly Met Asp Gly Ser Lys Pro Ala Gly Pro 
1               5                   10                  15      


Arg Asp Phe Pro Gly Ile Arg Leu Leu Ser Asn Pro Leu Met Gly Asp 
            20                  25                  30          


Ala Val Ser Asp Trp Ser Pro Met His Glu Ala Ala Ile His Gly His 
        35                  40                  45              


Gln Leu Ser Leu Arg Asn Leu Ile Ser Gln Gly Trp Ala Val Asn Ile 
    50                  55                  60                  


Ile Thr Ala Asp His Val Ser Pro Leu His Glu Ala Cys Leu Gly Gly 
65                  70                  75                  80  


His Leu Ser Cys Val Lys Ile Leu Leu Lys His Gly Ala Gln Val Asn 
                85                  90                  95      


Gly Val Thr Ala Asp Trp His Thr Pro Leu Phe Asn Ala Cys Val Ser 
            100                 105                 110         


Gly Ser Trp Asp Cys Val Asn Leu Leu Leu Gln His Gly Ala Ser Val 
        115                 120                 125             


Gln Pro Glu Ser Asp Leu Ala Ser Pro Ile His Glu Ala Ala Arg Arg 
    130                 135                 140                 


Gly His Val Glu Cys Val Asn Ser Leu Ile Ala Tyr Gly Gly Asn Ile 
145                 150                 155                 160 


Asp His Lys Ile Ser His Leu Gly Thr Pro Leu Tyr Leu Ala Cys Glu 
                165                 170                 175     


Asn Gln Gln Arg Ala Cys Val Lys Lys Leu Leu Glu Ser Gly Ala Asp 
            180                 185                 190         


Val Asn Gln Gly Lys Gly Gln Asp Ser Pro Leu His Ala Val Ala Arg 
        195                 200                 205             


Thr Ala Ser Glu Glu Leu Ala Cys Leu Leu Met Asp Phe Gly Ala Asp 
    210                 215                 220                 


Thr Gln Ala Lys Asn Ala Glu Gly Lys Arg Pro Val Glu Leu Val Pro 
225                 230                 235                 240 


Pro Glu Ser Pro Leu Ala Gln Leu Phe Leu Glu Arg Glu Gly Pro Pro 
                245                 250                 255     


Ser Leu Met Gln Leu Cys Arg Leu Arg Ile Arg Lys Cys Phe Gly Ile 
            260                 265                 270         


Gln Gln His His Lys Ile Thr Lys Leu Val Leu Pro Glu Asp Leu Lys 
        275                 280                 285             


Gln Phe Leu Leu His Leu 
    290                 


<210>  648
<211>  252
<212>  PRT
<213>  Homo sapiens

<400>  648

Met Asp Gly Lys Gln Gly Gly Met Asp Gly Ser Lys Pro Ala Gly Pro 
1               5                   10                  15      


Arg Asp Phe Pro Gly Ile Arg Leu Leu Ser Asn Pro Leu Met Gly Asp 
            20                  25                  30          


Ala Val Ser Asp Trp Ser Pro Met His Glu Ala Ala Ile His Gly His 
        35                  40                  45              


Gln Leu Ser Leu Arg Asn Leu Ile Ser Gln Gly Trp Ala Val Asn Ile 
    50                  55                  60                  


Ile Thr Ala Asp His Val Ser Pro Leu His Glu Ala Cys Leu Gly Gly 
65                  70                  75                  80  


His Leu Ser Cys Val Lys Ile Leu Leu Lys His Gly Ala Gln Val Asn 
                85                  90                  95      


Gly Val Thr Ala Asp Trp His Thr Pro Leu Phe Asn Ala Cys Val Ser 
            100                 105                 110         


Gly Ser Trp Asp Cys Val Asn Leu Leu Leu Gln His Gly Ala Ser Val 
        115                 120                 125             


Gln Pro Glu Ser Asp Leu Ala Ser Pro Ile His Glu Ala Ala Arg Arg 
    130                 135                 140                 


Ala Tyr Gly Gly Asn Ile Asp His Lys Ile Ser His Leu Gly Thr Pro 
145                 150                 155                 160 


Leu Tyr Leu Ala Cys Glu Asn Gln Gln Arg Ala Cys Val Lys Lys Leu 
                165                 170                 175     


Leu Glu Ser Gly Ala Asp Val Asn Gln Gly Lys Gly Gln Asp Ser Pro 
            180                 185                 190         


Leu His Ala Val Ala Arg Thr Ala Ser Glu Glu Leu Ala Cys Leu Leu 
        195                 200                 205             


Met Asp Phe Gly Ala Asp Thr Gln Ala Lys Asn Ala Glu Gly Lys Arg 
    210                 215                 220                 


Pro Val Glu Leu Val Pro Pro Glu Ser Pro Leu Ala Gln Leu Phe Leu 
225                 230                 235                 240 


Glu Arg Glu Gly Ala Ser Leu Pro Lys Pro Lys Pro 
                245                 250         


<210>  649
<211>  2121
<212>  DNA
<213>  Homo sapiens

<400>  649
acaaggcagc ctcgctcgag cgcaggccaa tcggctttct agctagaggg tttaactcct       60

atttaaaaag aagaaccttt gaattctaac ggctgagctc ttggaagact tgggtccttg      120

ggtcgcaggc atcatggacc gatctaaaga aaactgcatt tcaggacctg ttaaggctac      180

agctccagtt ggaggtccaa aacgtgttct cgtgactcag caatttcctt gtcagaatcc      240

attacctgta aatagtggcc aggctcagcg ggtcttgtgt ccttcaaatt cttcccagcg      300

cattcctttg caagcacaaa agcttgtctc cagtcacaag ccggttcaga atcagaagca      360

gaagcaattg caggcaacca gtgtacctca tcctgtctcc aggccactga ataacaccca      420

aaagagcaag cagcccctgc catcggcacc tgaaaataat cctgaggagg aactggcatc      480

aaaacagaaa aatgaagaat caaaaaagag gcagtgggct ttggaagact ttgaaattgg      540

tcgccctctg ggtaaaggaa agtttggtaa tgtttatttg gcaagagaaa agcaaagcaa      600

gtttattctg gctcttaaag tgttatttaa agctcagctg gagaaagccg gagtggagca      660

tcagctcaga agagaagtag aaatacagtc ccaccttcgg catcctaata ttcttagact      720

gtatggttat ttccatgatg ctaccagagt ctacctaatt ctggaatatg caccacttgg      780

aacagtttat agagaacttc agaaactttc aaagtttgat gagcagagaa ctgctactta      840

tataacagaa ttggcaaatg ccctgtctta ctgtcattcg aagagagtta ttcatagaga      900

cattaagcca gagaacttac ttcttggatc agctggagag cttaaaattg cagattttgg      960

gtggtcagta catgctccat cttccaggag gaccactctc tgtggcaccc tggactacct     1020

gccccctgaa atgattgaag gtcggatgca tgatgagaag gtggatctct ggagccttgg     1080

agttctttgc tatgaatttt tagttgggaa gcctcctttt gaggcaaaca cataccaaga     1140

gacctacaaa agaatatcac gggttgaatt cacattccct gactttgtaa cagagggagc     1200

cagggacctc atttcaagac tgttgaagca taatcccagc cagaggccaa tgctcagaga     1260

agtacttgaa cacccctgga tcacagcaaa ttcatcaaaa ccatcaaatt gccaaaacaa     1320

agaatcagct agcaaacagt cttaggaatc gtgcaggggg agaaatcctt gagccagggc     1380

tgccatataa cctgacagga acatgctact gaagtttatt ttaccattga ctgctgccct     1440

caatctagaa cgctacacaa gaaatatttg ttttactcag caggtgtgcc ttaacctccc     1500

tattcagaaa gctccacatc aataaacatg acactctgaa gtgaaagtag ccacgagaat     1560

tgtgctactt atactggttc ataatctgga ggcaaggttc gactgcagcc gccccgtcag     1620

cctgtgctag gcatggtgtc ttcacaggag gcaaatccag agcctggctg tggggaaagt     1680

gaccactctg ccctgacccc gatcagttaa ggagctgtgc aataaccttc ctagtacctg     1740

agtgagtgtg taacttattg ggttggcgaa gcctggtaaa gctgttggaa tgagtatgtg     1800

attcttttta agtatgaaaa taaagatata tgtacagact tgtatttttt ctctggtggc     1860

attcctttag gaatgctgtg tgtctgtccg gcaccccggt aggcctgatt gggtttctag     1920

tcctccttaa ccacttatct cccatatgag agtgtgaaaa ataggaacac gtgctctacc     1980

tccatttagg gatttgcttg ggatacagaa gaggccatgt gtctcagagc tgttaagggc     2040

ttattttttt aaaacattgg agtcatagca tgtgtgtaaa ctttaaatat gcaaataaat     2100

aagtatctat gtctaaaaaa a                                               2121


<210>  650
<211>  403
<212>  PRT
<213>  Homo sapiens

<400>  650

Met Asp Arg Ser Lys Glu Asn Cys Ile Ser Gly Pro Val Lys Ala Thr 
1               5                   10                  15      


Ala Pro Val Gly Gly Pro Lys Arg Val Leu Val Thr Gln Gln Phe Pro 
            20                  25                  30          


Cys Gln Asn Pro Leu Pro Val Asn Ser Gly Gln Ala Gln Arg Val Leu 
        35                  40                  45              


Cys Pro Ser Asn Ser Ser Gln Arg Val Pro Leu Gln Ala Gln Lys Leu 
    50                  55                  60                  


Val Ser Ser His Lys Pro Val Gln Asn Gln Lys Gln Lys Gln Leu Gln 
65                  70                  75                  80  


Ala Thr Ser Val Pro His Pro Val Ser Arg Pro Leu Asn Asn Thr Gln 
                85                  90                  95      


Lys Ser Lys Gln Pro Leu Pro Ser Ala Pro Glu Asn Asn Pro Glu Glu 
            100                 105                 110         


Glu Leu Ala Ser Lys Gln Lys Asn Glu Glu Ser Lys Lys Arg Gln Trp 
        115                 120                 125             


Ala Leu Glu Asp Phe Glu Ile Gly Arg Pro Leu Gly Lys Gly Lys Phe 
    130                 135                 140                 


Gly Asn Val Tyr Leu Ala Arg Glu Lys Gln Ser Lys Phe Ile Leu Ala 
145                 150                 155                 160 


Leu Lys Val Leu Phe Lys Ala Gln Leu Glu Lys Ala Gly Val Glu His 
                165                 170                 175     


Gln Leu Arg Arg Glu Val Glu Ile Gln Ser His Leu Arg His Pro Asn 
            180                 185                 190         


Ile Leu Arg Leu Tyr Gly Tyr Phe His Asp Ala Thr Arg Val Tyr Leu 
        195                 200                 205             


Ile Leu Glu Tyr Ala Pro Leu Gly Thr Val Tyr Arg Glu Leu Gln Lys 
    210                 215                 220                 


Leu Ser Lys Phe Asp Glu Gln Arg Thr Ala Thr Tyr Ile Thr Glu Leu 
225                 230                 235                 240 


Ala Asn Ala Leu Ser Tyr Cys His Ser Lys Arg Val Ile His Arg Asp 
                245                 250                 255     


Ile Lys Pro Glu Asn Leu Leu Leu Gly Ser Ala Gly Glu Leu Lys Ile 
            260                 265                 270         


Ala Asp Phe Gly Trp Ser Val His Ala Pro Ser Ser Arg Arg Thr Thr 
        275                 280                 285             


Leu Cys Gly Thr Leu Asp Tyr Leu Pro Pro Glu Met Ile Glu Gly Arg 
    290                 295                 300                 


Met His Asp Glu Lys Val Asp Leu Trp Ser Leu Gly Val Leu Cys Tyr 
305                 310                 315                 320 


Glu Phe Leu Val Gly Lys Pro Pro Phe Glu Ala Asn Thr Tyr Gln Glu 
                325                 330                 335     


Thr Tyr Lys Arg Ile Ser Arg Val Glu Phe Thr Phe Pro Asp Phe Val 
            340                 345                 350         


Thr Glu Gly Ala Arg Asp Leu Ile Ser Arg Leu Leu Lys His Asn Pro 
        355                 360                 365             


Ser Gln Arg Pro Met Leu Arg Glu Val Leu Glu His Pro Trp Ile Thr 
    370                 375                 380                 


Ala Asn Ser Ser Lys Pro Ser Asn Cys Gln Asn Lys Glu Ser Ala Ser 
385                 390                 395                 400 


Lys Gln Ser 
            


<210>  651
<211>  403
<212>  PRT
<213>  Homo sapiens

<400>  651

Met Asp Arg Ser Lys Glu Asn Cys Ile Ser Gly Pro Val Lys Ala Thr 
1               5                   10                  15      


Ala Pro Val Gly Gly Pro Lys Arg Val Leu Val Thr Gln Gln Phe Pro 
            20                  25                  30          


Cys Gln Asn Pro Leu Pro Val Asn Ser Gly Gln Ala Gln Arg Val Leu 
        35                  40                  45              


Cys Pro Ser Asn Ser Ser Gln Arg Val Pro Leu Gln Ala Gln Lys Leu 
    50                  55                  60                  


Val Ser Ser His Lys Pro Val Gln Asn Gln Lys Gln Lys Gln Leu Gln 
65                  70                  75                  80  


Ala Thr Ser Val Pro His Pro Val Ser Arg Pro Leu Asn Asn Thr Gln 
                85                  90                  95      


Lys Ser Lys Gln Pro Leu Pro Ser Ala Pro Glu Asn Asn Pro Glu Glu 
            100                 105                 110         


Glu Leu Ala Ser Lys Gln Lys Asn Glu Glu Ser Lys Lys Arg Gln Trp 
        115                 120                 125             


Ala Leu Glu Asp Phe Glu Ile Gly Arg Pro Leu Gly Lys Gly Lys Phe 
    130                 135                 140                 


Gly Asn Val Tyr Leu Ala Arg Glu Lys Gln Ser Lys Phe Ile Leu Ala 
145                 150                 155                 160 


Leu Lys Val Leu Phe Lys Ala Gln Leu Glu Lys Ala Gly Val Glu His 
                165                 170                 175     


Gln Leu Arg Arg Glu Val Glu Ile Gln Ser His Leu Arg His Pro Asn 
            180                 185                 190         


Ile Leu Arg Leu Tyr Gly Tyr Phe His Asp Ala Thr Arg Val Tyr Leu 
        195                 200                 205             


Ile Leu Glu Tyr Ala Pro Leu Gly Thr Val Tyr Arg Glu Leu Gln Lys 
    210                 215                 220                 


Leu Ser Lys Phe Asp Glu Gln Arg Thr Ala Thr Tyr Ile Thr Glu Leu 
225                 230                 235                 240 


Ala Asn Ala Leu Ser Tyr Cys His Ser Lys Arg Val Ile His Arg Asp 
                245                 250                 255     


Ile Lys Pro Glu Asn Leu Leu Leu Gly Ser Ala Gly Glu Leu Lys Ile 
            260                 265                 270         


Ala Asp Phe Gly Trp Ser Val His Ala Pro Ser Ser Arg Arg Thr Thr 
        275                 280                 285             


Leu Cys Gly Thr Leu Asp Tyr Leu Pro Pro Glu Met Ile Glu Gly Arg 
    290                 295                 300                 


Met His Asp Glu Lys Val Asp Leu Trp Ser Leu Gly Val Leu Cys Tyr 
305                 310                 315                 320 


Glu Phe Leu Val Gly Lys Pro Pro Phe Glu Ala Asn Thr Tyr Gln Glu 
                325                 330                 335     


Thr Tyr Lys Arg Ile Ser Arg Val Glu Phe Thr Phe Pro Asp Phe Val 
            340                 345                 350         


Thr Glu Gly Ala Arg Asp Leu Ile Ser Arg Leu Leu Lys His Asn Pro 
        355                 360                 365             


Ser Gln Arg Pro Met Leu Arg Glu Val Leu Glu His Pro Trp Ile Thr 
    370                 375                 380                 


Ala Asn Ser Ser Lys Pro Ser Asn Cys Gln Asn Lys Glu Ser Ala Ser 
385                 390                 395                 400 


Lys Gln Ser 
            


<210>  652
<211>  1253
<212>  DNA
<213>  Homo sapiens

<400>  652
gggcggccgg gagagtagca gtgccttgga ccccagctct cctccccctt tctctctaag       60

gatggcccag aaggagaact cctacccctg gccctacggc cgacagacgg ctccatctgg      120

cctgagcacc ctgccccagc gagtcctccg gaaagagcct gtcaccccat ctgcacttgt      180

cctcatgagc cgctccaatg tccagcccac agctgcccct ggccagaagg tgatggagaa      240

tagcagtggg acacccgaca tcttaacgcg gcacttcaca attgatgact ttgagattgg      300

gcgtcctctg ggcaaaggca agtttggaaa cgtgtacttg gctcgggaga agaaaagcca      360

tttcatcgtg gcgctcaagg tcctcttcaa gtcccagata gagaaggagg gcgtggagca      420

tcagctgcgc agagagatcg aaatccaggc ccacctgcac catcccaaca tcctgcgtct      480

ctacaactat ttttatgacc ggaggaggat ctacttgatt ctagagtatg ccccccgcgg      540

ggagctctac aaggagctgc agaagagctg cacatttgac gagcagcgaa cagccacgat      600

catggaggag ttggcagatg ctctaatgta ctgccatggg aagaaggtga ttcacagaga      660

cataaagcca gaaaatctgc tcttagggct caagggagag ctgaagattg ctgacttcgg      720

ctggtctgtg catgcgccct ccctgaggag gaagacaatg tgtggcaccc tggactacct      780

gcccccagag atgattgagg ggcgcatgca caatgagaag gtggatctgt ggtgcattgg      840

agtgctttgc tatgagctgc tggtggggaa cccacccttt gagagtgcat cacacaacga      900

gacctatcgc cgcatcgtca aggtggacct aaagttcccc gcttccgtgc ccatgggagc      960

ccaggacctc atctccaaac tgctcaggca taacccctcg gaacggctgc ccctggccca     1020

ggtctcagcc cacccttggg tccgggccaa ctctcggagg gtgctgcctc cctctgccct     1080

tcaatctgtc gcctgatggt ccctgtcatt cactcgggtg cgtgtgtttg tatgtctgtg     1140

tatgtatagg ggaaagaagg gatccctaac tgttccctta tctgttttct acctcctcct     1200

ttgtttaata aaggctgaag ctttttgtac tcatgaaaaa aaaaaaaaaa aaa            1253


<210>  653
<211>  344
<212>  PRT
<213>  Homo sapiens

<400>  653

Met Ala Gln Lys Glu Asn Ser Tyr Pro Trp Pro Tyr Gly Arg Gln Thr 
1               5                   10                  15      


Ala Pro Ser Gly Leu Ser Thr Leu Pro Gln Arg Val Leu Arg Lys Glu 
            20                  25                  30          


Pro Val Thr Pro Ser Ala Leu Val Leu Met Ser Arg Ser Asn Val Gln 
        35                  40                  45              


Pro Thr Ala Ala Pro Gly Gln Lys Val Met Glu Asn Ser Ser Gly Thr 
    50                  55                  60                  


Pro Asp Ile Leu Thr Arg His Phe Thr Ile Asp Asp Phe Glu Ile Gly 
65                  70                  75                  80  


Arg Pro Leu Gly Lys Gly Lys Phe Gly Asn Val Tyr Leu Ala Arg Glu 
                85                  90                  95      


Lys Lys Ser His Phe Ile Val Ala Leu Lys Val Leu Phe Lys Ser Gln 
            100                 105                 110         


Ile Glu Lys Glu Gly Val Glu His Gln Leu Arg Arg Glu Ile Glu Ile 
        115                 120                 125             


Gln Ala His Leu His His Pro Asn Ile Leu Arg Leu Tyr Asn Tyr Phe 
    130                 135                 140                 


Tyr Asp Arg Arg Arg Ile Tyr Leu Ile Leu Glu Tyr Ala Pro Arg Gly 
145                 150                 155                 160 


Glu Leu Tyr Lys Glu Leu Gln Lys Ser Cys Thr Phe Asp Glu Gln Arg 
                165                 170                 175     


Thr Ala Thr Ile Met Glu Glu Leu Ala Asp Ala Leu Met Tyr Cys His 
            180                 185                 190         


Gly Lys Lys Val Ile His Arg Asp Ile Lys Pro Glu Asn Leu Leu Leu 
        195                 200                 205             


Gly Leu Lys Gly Glu Leu Lys Ile Ala Asp Phe Gly Trp Ser Val His 
    210                 215                 220                 


Ala Pro Ser Leu Arg Arg Lys Thr Met Cys Gly Thr Leu Asp Tyr Leu 
225                 230                 235                 240 


Pro Pro Glu Met Ile Glu Gly Arg Met His Asn Glu Lys Val Asp Leu 
                245                 250                 255     


Trp Cys Ile Gly Val Leu Cys Tyr Glu Leu Leu Val Gly Asn Pro Pro 
            260                 265                 270         


Phe Glu Ser Ala Ser His Asn Glu Thr Tyr Arg Arg Ile Val Lys Val 
        275                 280                 285             


Asp Leu Lys Phe Pro Ala Ser Val Pro Thr Gly Ala Gln Asp Leu Ile 
    290                 295                 300                 


Ser Lys Leu Leu Arg His Asn Pro Ser Glu Arg Leu Pro Leu Ala Gln 
305                 310                 315                 320 


Val Ser Ala His Pro Trp Val Arg Ala Asn Ser Arg Arg Val Leu Pro 
                325                 330                 335     


Pro Ser Ala Leu Gln Ser Val Ala 
            340                 


<210>  654
<211>  344
<212>  PRT
<213>  Homo sapiens

<400>  654

Met Ala Gln Lys Glu Asn Ser Tyr Pro Trp Pro Tyr Gly Arg Gln Thr 
1               5                   10                  15      


Ala Pro Ser Gly Leu Ser Thr Leu Pro Gln Arg Val Leu Arg Lys Glu 
            20                  25                  30          


Pro Val Thr Pro Ser Ala Leu Val Leu Met Ser Arg Ser Asn Val Gln 
        35                  40                  45              


Pro Thr Ala Ala Pro Gly Gln Lys Val Met Glu Asn Ser Ser Gly Thr 
    50                  55                  60                  


Pro Asp Ile Leu Thr Arg His Phe Thr Ile Asp Asp Phe Glu Ile Gly 
65                  70                  75                  80  


Arg Pro Leu Gly Lys Gly Lys Phe Gly Asn Val Tyr Leu Ala Arg Glu 
                85                  90                  95      


Lys Lys Ser His Phe Ile Val Ala Leu Lys Val Leu Phe Lys Ser Gln 
            100                 105                 110         


Ile Glu Lys Glu Gly Val Glu His Gln Leu Arg Arg Glu Ile Glu Ile 
        115                 120                 125             


Gln Ala His Leu His His Pro Asn Ile Leu Arg Leu Tyr Asn Tyr Phe 
    130                 135                 140                 


Tyr Asp Arg Arg Arg Ile Tyr Leu Ile Leu Glu Tyr Ala Pro Arg Gly 
145                 150                 155                 160 


Glu Leu Tyr Lys Glu Leu Gln Lys Ser Cys Thr Phe Asp Glu Gln Arg 
                165                 170                 175     


Thr Ala Thr Ile Met Glu Glu Leu Ala Asp Ala Leu Met Tyr Cys His 
            180                 185                 190         


Gly Lys Lys Val Ile His Arg Asp Ile Lys Pro Glu Asn Leu Leu Leu 
        195                 200                 205             


Gly Leu Lys Gly Glu Leu Lys Ile Ala Asp Phe Gly Trp Ser Val His 
    210                 215                 220                 


Ala Pro Ser Leu Arg Arg Lys Thr Met Cys Gly Thr Leu Asp Tyr Leu 
225                 230                 235                 240 


Pro Pro Glu Met Ile Glu Gly Arg Met His Asn Glu Lys Val Asp Leu 
                245                 250                 255     


Trp Cys Ile Gly Val Leu Cys Tyr Glu Leu Leu Val Gly Asn Pro Pro 
            260                 265                 270         


Phe Glu Ser Ala Ser His Asn Glu Thr Tyr Arg Arg Ile Val Lys Val 
        275                 280                 285             


Asp Leu Lys Phe Pro Ala Ser Val Pro Met Gly Ala Gln Asp Leu Ile 
    290                 295                 300                 


Ser Lys Leu Leu Arg His Asn Pro Ser Glu Arg Leu Pro Leu Ala Gln 
305                 310                 315                 320 


Val Ser Ala His Pro Trp Val Arg Ala Asn Ser Arg Arg Val Leu Pro 
                325                 330                 335     


Pro Ser Ala Leu Gln Ser Val Ala 
            340                 


<210>  655
<211>  1125
<212>  DNA
<213>  Homo sapiens

<400>  655
ggaagtacct ctctgagcgg ttggtgccgg gtataaaaga aggccgcgca gccacggctg       60

ctcacgacgc cgcggatccc gaagcctgtg tagcagtgag acatcagtga gtggctacag      120

caaaccaaac agcccagcag cccagcagcc cagccatgcg gcgcctcaca gtcgatgact      180

ttgaaatcgg gcgtcccctg ggcaagggga aatttgggaa tgtgtacctg gctcggctca      240

aggaaagcca tttcattgtg gccctgaagg ttctcttcaa gtcgcagata gagaaggaag      300

gactggagca ccagctgcgc cgggaaattg agatccaggc tcatctacaa caccccaata      360

tcctgcgcct gtataactat ttccatgatg cacgccgggt gtacctgatt ctggaatatg      420

ctccaagggg tgagctctac aaggagctgc agaaaagcga gaaattagat gaacagcgca      480

cagccacgat aatagaggag ttggcagatg ccctgaccta ctgccatgac aagaaagtga      540

ttcacagaga tattaagcca gagaacctgc tgctggggtt caggggtgag gtgaagattg      600

cagattttgg ctggtctgtg cacaccccct ccctgaggag gaagacaatg tgtgggacac      660

tggactactt gccgccagaa atgattgagg ggagaacata tgatgaaaag gtggatttgt      720

ggtgcattgg agtgctctgc tatgagctgc tggtgggata tccacccttt gagagcgcct      780

cccacagtga gacttacaga cgcatcctca aggtagatgt gaggtttcca ctatcaatgc      840

ctctgggggc ccgggacttg atttccaggc ttctcagata ccagcccttg gagagactgc      900

ccctggccca gatcctgaag cacccctggg ttcaggccca ctcccgaagg gtgctgcctc      960

cctgtgctca gatggcttcc tgagccctgt ctgcctctgt tccctttgtg tgtgttcagg     1020

gagctctcct ggctctgcca cctcatttgt ctttattttt ttctctttta agatgtaaga     1080

tgctaattaa taaaagctga atcatttcat accaaaaaaa aaaaa                     1125


<210>  656
<211>  309
<212>  PRT
<213>  Homo sapiens

<400>  656

Met Ser Ser Pro Arg Ala Val Val Gln Leu Gly Lys Ala Gln Pro Ala 
1               5                   10                  15      


Gly Glu Glu Leu Ala Thr Ala Asn Gln Thr Ala Gln Gln Pro Ser Ser 
            20                  25                  30          


Pro Ala Met Arg Arg Leu Thr Val Asp Asp Phe Glu Ile Gly Arg Pro 
        35                  40                  45              


Leu Gly Lys Gly Lys Phe Gly Asn Val Tyr Leu Ala Arg Leu Lys Glu 
    50                  55                  60                  


Ser His Phe Ile Val Ala Leu Lys Val Leu Phe Lys Ser Gln Ile Glu 
65                  70                  75                  80  


Lys Glu Gly Leu Glu His Gln Leu Arg Arg Glu Ile Glu Ile Gln Ala 
                85                  90                  95      


His Leu Gln His Pro Asn Ile Leu Arg Leu Tyr Asn Tyr Phe His Asp 
            100                 105                 110         


Ala Arg Arg Val Tyr Leu Ile Leu Glu Tyr Ala Pro Arg Gly Glu Leu 
        115                 120                 125             


Tyr Lys Glu Leu Gln Lys Ser Glu Lys Leu Asp Glu Gln Arg Thr Ala 
    130                 135                 140                 


Thr Ile Ile Glu Glu Leu Ala Asp Ala Leu Thr Tyr Cys His Asp Lys 
145                 150                 155                 160 


Lys Val Ile His Arg Asp Ile Lys Pro Glu Asn Leu Leu Leu Gly Phe 
                165                 170                 175     


Arg Gly Glu Val Lys Ile Ala Asp Phe Gly Trp Ser Val His Thr Pro 
            180                 185                 190         


Ser Leu Arg Arg Lys Thr Met Cys Gly Thr Leu Asp Tyr Leu Pro Pro 
        195                 200                 205             


Glu Met Ile Glu Gly Arg Thr Tyr Asp Glu Lys Val Asp Leu Trp Cys 
    210                 215                 220                 


Ile Gly Val Leu Cys Tyr Glu Leu Leu Val Gly Tyr Pro Pro Phe Glu 
225                 230                 235                 240 


Ser Ala Ser His Ser Glu Thr Tyr Arg Arg Ile Leu Lys Val Asp Val 
                245                 250                 255     


Arg Phe Pro Leu Ser Met Pro Leu Gly Ala Arg Asp Leu Ile Ser Arg 
            260                 265                 270         


Leu Leu Arg Tyr Gln Pro Leu Glu Arg Leu Pro Leu Ala Gln Ile Leu 
        275                 280                 285             


Lys His Pro Trp Val Gln Ala His Ser Arg Arg Val Leu Pro Pro Cys 
    290                 295                 300                 


Ala Gln Met Ala Ser 
305                 


<210>  657
<211>  275
<212>  PRT
<213>  Homo sapiens

<400>  657

Met Arg Arg Leu Thr Val Asp Asp Phe Glu Ile Gly Arg Pro Leu Gly 
1               5                   10                  15      


Lys Gly Lys Phe Gly Asn Val Tyr Leu Ala Arg Leu Lys Glu Ser His 
            20                  25                  30          


Phe Ile Val Ala Leu Lys Val Leu Phe Lys Ser Gln Ile Glu Lys Glu 
        35                  40                  45              


Gly Leu Glu His Gln Leu Arg Arg Glu Ile Glu Ile Gln Ala His Leu 
    50                  55                  60                  


Gln His Pro Asn Ile Leu Arg Leu Tyr Asn Tyr Phe His Asp Ala Arg 
65                  70                  75                  80  


Arg Val Tyr Leu Ile Leu Glu Tyr Ala Pro Arg Gly Glu Leu Tyr Lys 
                85                  90                  95      


Glu Leu Gln Lys Ser Glu Lys Leu Asp Glu Gln Arg Thr Ala Thr Ile 
            100                 105                 110         


Ile Glu Glu Leu Ala Asp Ala Leu Thr Tyr Cys His Asp Lys Lys Val 
        115                 120                 125             


Ile His Arg Asp Ile Lys Pro Glu Asn Leu Leu Leu Gly Phe Arg Gly 
    130                 135                 140                 


Glu Val Lys Ile Ala Asp Phe Gly Trp Ser Val His Thr Pro Ser Leu 
145                 150                 155                 160 


Arg Arg Lys Thr Met Cys Gly Thr Leu Asp Tyr Leu Pro Pro Glu Met 
                165                 170                 175     


Ile Glu Gly Arg Thr Tyr Asp Glu Lys Val Asp Leu Trp Cys Ile Gly 
            180                 185                 190         


Val Leu Cys Tyr Glu Leu Leu Val Gly Tyr Pro Pro Phe Glu Ser Ala 
        195                 200                 205             


Ser His Ser Glu Thr Tyr Arg Arg Ile Leu Lys Val Asp Val Arg Phe 
    210                 215                 220                 


Pro Leu Ser Met Pro Leu Gly Ala Arg Asp Leu Ile Ser Arg Leu Leu 
225                 230                 235                 240 


Arg Tyr Gln Pro Leu Glu Arg Leu Pro Leu Ala Gln Ile Leu Lys His 
                245                 250                 255     


Pro Trp Val Gln Ala His Ser Arg Arg Val Leu Pro Pro Cys Ala Gln 
            260                 265                 270         


Met Ala Ser 
        275 


<210>  658
<211>  2060
<212>  DNA
<213>  Homo sapiens

<400>  658
caagaactga cgtctaagca aggaggtcgc tgtagccctg ttccaggtct atcaagcagc       60

ccttctgggt cacccttgca tgggaaactg aacagccaag actcctataa caattttacc      120

aacaacaacc ctggcaaccc tcggctctct cctcttccca gcttgatggt agtgatgcct      180

cttgcacaaa tcaagcagcc aatgacattg gggaccatca ccaaacgaac cggcaaagtt      240

aaacctcctc cacaaatttc acccagcaaa tcgatgggcg gagaattttg tgtggctgct      300

atcttcggaa catccaggtc atggtttgca aataatgcag gtctgaaaag agaaaaagat      360

cagtccaaac aagttgtagt tgagtccctg tacattatca gttgctatgg caccttagtg      420

gaacacatga tggagccgcg acccctcagc actgcaccca agattagtga cgacacacca      480

ctggaaatga tgacatcgcc tcgagccagc tggactctgg ttagaacccc tcaatggaat      540

gaattgcagc caccgtttaa tgcaaaccac cctctgctcc tcgctgcaga tgcagtacag      600

tattatcagt tcctgcttgc tggcctggtt ccccctggaa gtcctgggcc cattactcga      660

catgggtctt acgacagttt agcttctgac catagtggac aggaagatga agaatggctt      720

tcccaggttg aaattgtaac acacactgga ccccatagac gtctgtggat gggtccacag      780

ttccagttca aaaccatcca tccctcaggc caaaccacag ttatctcatc cagttcatct      840

gtgttgcagt ctcatggtcc gagtgacacg ccacagcctc ttttggattt tgatacagat      900

gatcttgatc tcaacagtct caggatccag ccagtccgct ctgaccccgt cagcatgcca      960

gggtcatccc gtccagtctc tgatcgaagg ggagtttcca cagtgattga tgctgcctca     1020

ggtacctttg acaggagcgt gaccctgctg gaggtgtgcg ggagctggcc tgagggcttc     1080

gggctgcggc acatgtcctc catggagcac acggaggagg gcctccggga gcgacttgcc     1140

gacgccatgg ccgagtcacc tagccgggac gtcgtgggat ccggaacaga acttcagcga     1200

gagggaagca tcgagactct gagtaacagc tcaggctcca ccagcggcag cataccaaga     1260

aactttgatg gctaccgatc tccgctgccc accaatgaga gccagcccct cagcctcttc     1320

ccgactggct tcccgtaggt accagcaacc tgcttctgac tggccagccc cctcccctgc     1380

tggaggaggg gagaagcccc gctctggtcc tacccttcag tctctgctct tccttcatca     1440

accaccttcc ccaagcttag tgacagcagc cgcccatcct acctggatgg agaagagacc     1500

cttctccaag cacctcagcg cacttgccct ctgccacacc tgtcggtgga ggctgtggcc     1560

aggagagact gtagaagctc ggtccctgtg tatgtttgca tatgacatcc tgcattggat     1620

ccgcttttgt attttttaac catacccacg gtggggcggg tggggggagc ctggaacagt     1680

gaccagatct gggggcctga gtggggacag agttgatcgt ccacctggcc attttgaccc     1740

tgagtggaca gtcacagcct cagctcatgt ctggctgtga cacacactgc ccccagcttc     1800

ccttggtcag ccccactcca gcacggggtg aacggaggcc cagagtacta gggaaggagg     1860

aagggaggac atgcctcttc ttcctccttt ctttccccat ctgttcatgg gaagagtttg     1920

tctttcttat ctttaagccc ctttaccctg gtcctgtact gatcagtgaa ggaaaccgtg     1980

gttactgagg ccctgttgaa aagtgcacgt cttgtccaat aaatcacgct gcagttggtg     2040

tccaaaaaaa aaaaaaaaaa                                                 2060


<210>  659
<211>  928
<212>  PRT
<213>  Homo sapiens

<400>  659

Met Asn Glu Ala Met Ala Thr Asp Ser Pro Arg Arg Pro Ser Arg Cys 
1               5                   10                  15      


Thr Gly Gly Val Val Val Arg Pro Gln Ala Val Thr Glu Gln Ser Tyr 
            20                  25                  30          


Met Glu Ser Val Val Thr Phe Leu Gln Asp Val Val Pro Gln Ala Tyr 
        35                  40                  45              


Ser Gly Thr Pro Leu Thr Glu Glu Lys Glu Lys Ile Val Trp Val Arg 
    50                  55                  60                  


Phe Glu Asn Ala Asp Leu Asn Asp Thr Ser Arg Asn Leu Glu Phe His 
65                  70                  75                  80  


Glu Ile His Ser Thr Gly Asn Glu Pro Pro Leu Leu Ile Met Ile Gly 
                85                  90                  95      


Tyr Ser Asp Gly Met Gln Val Trp Ser Ile Pro Ile Ser Gly Glu Ala 
            100                 105                 110         


Gln Glu Leu Phe Ser Val Arg His Gly Pro Ile Arg Ala Ala Arg Ile 
        115                 120                 125             


Leu Pro Ala Pro Gln Phe Gly Ala Gln Lys Cys Asp Asn Phe Ala Glu 
    130                 135                 140                 


Lys Arg Pro Leu Leu Gly Val Cys Lys Ser Ile Gly Ser Ser Gly Thr 
145                 150                 155                 160 


Ser Pro Pro Tyr Cys Cys Val Asp Leu Tyr Ser Leu Arg Thr Gly Glu 
                165                 170                 175     


Met Val Lys Ser Ile Gln Phe Lys Thr Pro Ile Tyr Asp Leu His Cys 
            180                 185                 190         


Asn Lys Arg Ile Leu Val Val Val Leu Gln Glu Lys Ile Ala Ala Phe 
        195                 200                 205             


Asp Ser Cys Thr Phe Thr Lys Lys Phe Phe Val Thr Ser Cys Tyr Pro 
    210                 215                 220                 


Cys Pro Gly Pro Asn Met Asn Pro Ile Ala Leu Gly Ser Arg Trp Leu 
225                 230                 235                 240 


Ala Tyr Ala Glu Asn Lys Leu Ile Arg Cys His Gln Ser Arg Gly Gly 
                245                 250                 255     


Ala Cys Gly Asp Asn Ile Gln Ser Tyr Thr Ala Thr Val Ile Ser Ala 
            260                 265                 270         


Ala Lys Thr Leu Lys Ser Gly Leu Thr Met Val Gly Lys Val Val Thr 
        275                 280                 285             


Gln Leu Thr Gly Thr Leu Pro Ser Gly Val Thr Glu Asp Asp Val Ala 
    290                 295                 300                 


Ile His Ser Asn Ser Arg Arg Ser Pro Leu Val Pro Gly Ile Ile Thr 
305                 310                 315                 320 


Val Ile Asp Thr Glu Thr Val Gly Glu Gly Gln Val Leu Val Ser Glu 
                325                 330                 335     


Asp Ser Asp Ser Asp Gly Ile Val Ala His Phe Pro Ala His Glu Lys 
            340                 345                 350         


Pro Val Cys Cys Met Ala Phe Asn Thr Ser Gly Met Leu Leu Val Thr 
        355                 360                 365             


Thr Asp Thr Leu Gly His Asp Phe His Val Phe Gln Ile Leu Thr His 
    370                 375                 380                 


Pro Trp Ser Ser Ser Gln Cys Ala Val His His Leu Tyr Thr Leu His 
385                 390                 395                 400 


Arg Gly Glu Thr Glu Ala Lys Val Gln Asp Ile Cys Phe Ser His Asp 
                405                 410                 415     


Cys Arg Trp Val Val Val Ser Thr Leu Arg Gly Thr Ser His Val Phe 
            420                 425                 430         


Pro Ile Asn Pro Tyr Gly Gly Gln Pro Cys Val Arg Thr His Met Ser 
        435                 440                 445             


Pro Arg Val Val Asn Arg Met Ser Arg Phe Gln Lys Ser Ala Gly Leu 
    450                 455                 460                 


Glu Glu Ile Glu Gln Glu Leu Thr Ser Lys Gln Gly Gly Arg Cys Ser 
465                 470                 475                 480 


Pro Val Pro Gly Leu Ser Ser Ser Pro Ser Gly Ser Pro Leu His Gly 
                485                 490                 495     


Lys Leu Asn Ser Gln Asp Ser Tyr Asn Asn Phe Thr Asn Asn Asn Pro 
            500                 505                 510         


Gly Asn Pro Arg Leu Ser Pro Leu Pro Ser Leu Met Val Val Met Pro 
        515                 520                 525             


Leu Ala Gln Ile Lys Gln Pro Met Thr Leu Gly Thr Ile Thr Lys Arg 
    530                 535                 540                 


Thr Gly Pro Tyr Leu Phe Gly Ala Gly Cys Phe Ser Ile Lys Ala Pro 
545                 550                 555                 560 


Cys Lys Val Lys Pro Pro Pro Gln Ile Ser Pro Ser Lys Ser Met Gly 
                565                 570                 575     


Gly Glu Phe Cys Val Ala Ala Ile Phe Gly Thr Ser Arg Ser Trp Phe 
            580                 585                 590         


Ala Asn Asn Ala Gly Leu Lys Arg Glu Lys Asp Gln Ser Lys Gln Val 
        595                 600                 605             


Val Val Glu Ser Leu Tyr Ile Ile Ser Cys Tyr Gly Thr Leu Val Glu 
    610                 615                 620                 


His Met Met Glu Pro Arg Pro Leu Ser Thr Ala Pro Lys Ile Ser Asp 
625                 630                 635                 640 


Asp Thr Pro Leu Glu Met Met Thr Ser Pro Arg Ala Ser Trp Thr Leu 
                645                 650                 655     


Val Arg Thr Pro Gln Trp Asn Glu Leu Gln Pro Pro Phe Asn Ala Asn 
            660                 665                 670         


His Pro Leu Leu Leu Ala Ala Asp Ala Val Gln Tyr Tyr Gln Phe Leu 
        675                 680                 685             


Leu Ala Gly Leu Val Pro Pro Gly Ser Pro Gly Pro Ile Thr Arg His 
    690                 695                 700                 


Gly Ser Tyr Asp Ser Leu Ala Ser Asp His Ser Gly Gln Glu Asp Glu 
705                 710                 715                 720 


Glu Trp Leu Ser Gln Val Glu Ile Val Thr His Thr Gly Pro His Arg 
                725                 730                 735     


Arg Leu Trp Met Gly Pro Gln Phe Gln Phe Lys Thr Ile His Pro Ser 
            740                 745                 750         


Gly Gln Thr Thr Val Ile Ser Ser Ser Ser Ser Val Leu Gln Ser His 
        755                 760                 765             


Gly Pro Ser Asp Thr Pro Gln Pro Leu Leu Asp Phe Asp Thr Asp Asp 
    770                 775                 780                 


Leu Asp Leu Asn Ser Leu Arg Ile Gln Pro Val Arg Ser Asp Pro Val 
785                 790                 795                 800 


Ser Met Pro Gly Ser Ser Arg Pro Val Ser Asp Arg Arg Gly Val Ser 
                805                 810                 815     


Thr Val Ile Asp Ala Ala Ser Gly Thr Phe Asp Arg Ser Val Thr Leu 
            820                 825                 830         


Leu Glu Val Cys Gly Ser Trp Pro Glu Gly Phe Gly Leu Arg His Met 
        835                 840                 845             


Ser Ser Met Glu His Thr Glu Glu Gly Leu Arg Glu Arg Leu Ala Asp 
    850                 855                 860                 


Ala Met Ala Glu Ser Pro Ser Arg Asp Val Val Gly Ser Gly Thr Glu 
865                 870                 875                 880 


Leu Gln Arg Glu Gly Ser Ile Glu Thr Leu Ser Asn Ser Ser Gly Ser 
                885                 890                 895     


Thr Ser Gly Ser Ile Pro Arg Asn Phe Asp Gly Tyr Arg Ser Pro Leu 
            900                 905                 910         


Pro Thr Asn Glu Ser Gln Pro Leu Ser Leu Phe Pro Thr Gly Phe Pro 
        915                 920                 925             


<210>  660
<211>  390
<212>  PRT
<213>  Homo sapiens

<400>  660

Met Val Val Met Pro Leu Ala Gln Ile Lys Gln Pro Met Thr Leu Gly 
1               5                   10                  15      


Thr Ile Thr Lys Arg Thr Gly Lys Val Lys Pro Pro Pro Gln Ile Ser 
            20                  25                  30          


Pro Ser Lys Ser Met Gly Gly Glu Phe Cys Val Ala Ala Ile Phe Gly 
        35                  40                  45              


Thr Ser Arg Ser Trp Phe Ala Asn Asn Ala Gly Leu Lys Arg Glu Lys 
    50                  55                  60                  


Asp Gln Ser Lys Gln Val Val Val Glu Ser Leu Tyr Ile Ile Ser Cys 
65                  70                  75                  80  


Tyr Gly Thr Leu Val Glu His Met Met Glu Pro Arg Pro Leu Ser Thr 
                85                  90                  95      


Ala Pro Lys Ile Ser Asp Asp Thr Pro Leu Glu Met Met Thr Ser Pro 
            100                 105                 110         


Arg Ala Ser Trp Thr Leu Val Arg Thr Pro Gln Trp Asn Glu Leu Gln 
        115                 120                 125             


Pro Pro Phe Asn Ala Asn His Pro Leu Leu Leu Ala Ala Asp Ala Val 
    130                 135                 140                 


Gln Tyr Tyr Gln Phe Leu Leu Ala Gly Leu Val Pro Pro Gly Ser Pro 
145                 150                 155                 160 


Gly Pro Ile Thr Arg His Gly Ser Tyr Asp Ser Leu Ala Ser Asp His 
                165                 170                 175     


Ser Gly Gln Glu Asp Glu Glu Trp Leu Ser Gln Val Glu Ile Val Thr 
            180                 185                 190         


His Thr Gly Pro His Arg Arg Leu Trp Met Gly Pro Gln Phe Gln Phe 
        195                 200                 205             


Lys Thr Ile His Pro Ser Gly Gln Thr Thr Val Ile Ser Ser Ser Ser 
    210                 215                 220                 


Ser Val Leu Gln Ser His Gly Pro Ser Asp Thr Pro Gln Pro Leu Leu 
225                 230                 235                 240 


Asp Phe Asp Thr Asp Asp Leu Asp Leu Asn Ser Leu Arg Ile Gln Pro 
                245                 250                 255     


Val Arg Ser Asp Pro Val Ser Met Pro Gly Ser Ser Arg Pro Val Ser 
            260                 265                 270         


Asp Arg Arg Gly Val Ser Thr Val Ile Asp Ala Ala Ser Gly Thr Phe 
        275                 280                 285             


Asp Arg Ser Val Thr Leu Leu Glu Val Cys Gly Ser Trp Pro Glu Gly 
    290                 295                 300                 


Phe Gly Leu Arg His Met Ser Ser Met Glu His Thr Glu Glu Gly Leu 
305                 310                 315                 320 


Arg Glu Arg Leu Ala Asp Ala Met Ala Glu Ser Pro Ser Arg Asp Val 
                325                 330                 335     


Val Gly Ser Gly Thr Glu Leu Gln Arg Glu Gly Ser Ile Glu Thr Leu 
            340                 345                 350         


Ser Asn Ser Ser Gly Ser Thr Ser Gly Ser Ile Pro Arg Asn Phe Asp 
        355                 360                 365             


Gly Tyr Arg Ser Pro Leu Pro Thr Asn Glu Ser Gln Pro Leu Ser Leu 
    370                 375                 380                 


Phe Pro Thr Gly Phe Pro 
385                 390 


<210>  661
<211>  3775
<212>  DNA
<213>  Homo sapiens

<400>  661
ggcagctagg agggttgctc cgggcttggt gctcactgcg acttcccgcg cagggcccgg       60

tcggactagg acccgcggcc tgagagacgc tggaggatgc ggacgcggag gccgcctggg      120

gtagcggcgg cgggagtcct ggcgctctgc aggtcagaag ttgagtagca ggggcctagg      180

agggctcgaa gccttcacag cgatggcaga gaagcgaccc ctgagaaccc tggggcctgt      240

gatgtatggc aagctgcccc gcttagagac agactccggg ctcgagcaca gcctgcccca      300

ctctgttggt aaccaggatc cctgcaccta caaggggtcc tacttctcct gccccatggc      360

gggtactcct aaggccgagt ctgagcagtt ggcgtcctgg accccatacc cacccttgta      420

ctctaccggt atggcaggac ccccacttca ggcagacaac ctgctgacca actgcctgtt      480

ctaccgctcg ccagcagaag gccctgagaa gatgcaggac tccagccctg ttgagctcct      540

gcccttcagt ccccaggctc actcctaccc aggcccacca ctggcagcac ccaaacctgt      600

ctaccgcaac cctctgtgct atgggctctc aacttgtctg ggggaaggag cagtgaagag      660

gccactggat gttgactgga ctctggcgac tgggcccctg ttgccctcag ctgacccacc      720

ctgctctctg gccccagctc ctagcaaggg ccagactctg gatggcacct tcttgcgggg      780

ggtgccagct gaggggtcca gtaaagactc ctcagggagc ttctccccat gccagccctt      840

cctggagaaa tatcagacca tccacagcac gggcttcctg gcctccaggt acacaggtcc      900

ttaccctagg aactccaagc aagcaatgtc tgaggggccc tcaagtcctt ggacccagct      960

ggcccagccc ctggggccac cctgtcagga caccgggccc acccactacc caccacccca     1020

ccacccacca ccccaccctc cacaggccct gccttgccct ccagcctgtc gccacccaga     1080

gaagcagggc agctacagcc cagcactccc actgcagcct ctggggggcc acaaggggac     1140

cgggtaccag gctggtgggc tgggcagccc ctacctgagg cagcaggcag cccaggcacc     1200

ttacattccc ccactggggc tggacgctta cccctacccc tctgcccctc tcccagcacc     1260

ctctccaggc ctcaagctgg agccgcctct cactccacgg tgcccattgg actttgcccc     1320

ccagacactg agttttcctt atgcccggga tgacctctct ctctatggag catcccctgg     1380

gcttggaggg acaccacctt cccagaacaa tgtgagggct gtgccacagc ccggtgcctt     1440

ccagagggca tgccagcctt tgccagcgag ccagccctgc tcagagcctg tgaggcctgc     1500

acaggaagcc gaagagaaga cctggctgcc cagctgcagg aaagagaagc tccagccccg     1560

gctcagtgag cactctgggc cgcccatcgt catccgagac agtccagttc cctgtacccc     1620

cccagcactg cccccctgtg cccgggagtg ccagtctctt ccacagaagg aggacgcaag     1680

gccacccagc tctccaccaa tgcctgtcat tgacaatgtc ttcagcctgg ccccctaccg     1740

tgactatctg gatgtgccgg cacccgaggc cacaactgag cctgactctg ccacagctga     1800

gcctgactca gccccagcca ccagtgaagg tcaggacaaa ggctgcaggg ggaccctgcc     1860

tgcccaggag ggcccctcag ggagtaaacc cctaaggggc tcacttaagg aggaggtagc     1920

cctggatttg agtgtgagga agcccacagc agaggcctcc cctgtcaagg cttcccgttc     1980

tgtggagcat gccaagccta ctgcagccat ggatgtgcca gatgtgggca acatggtgtc     2040

agatctgcca ggcctgaaaa agatagacac agaagcacca ggcttgcctg gggtgccagt     2100

gaccacagat gccatgccaa ggaccaactt ccacagctct gtggccttca tgttccgaaa     2160

gttcaagatc ctccgtccgg cacctttgcc tgcagccgtg gtcccgtcca cgcccacctc     2220

agctcctgct cccacacagc ctgcacccac ccccacatct gggcccattg gactgcggat     2280

tctcgctcaa cagcccttgt ctgtgacctg cttcagcctg gcactgccca gccctccagc     2340

cgtagctgtg gcctcccctg cccctgctcc agctccatcc cctgctccgg ctcgagctca     2400

ggctccagct tcagcccggg atccagctcc agctccagct ccagttgcag gccctgctcc     2460

agcatctact tcagccccag gggactccct ggagcagcat tttacaggac tacatgcgtc     2520

cctgtgtgat gctatttctg gctccgtcgc ccactctcct ccagagaagc ttcgcgagtg     2580

gctagagacg gctgggccct ggggccaggc tgcgtggcag gactgccagg gtgtgcaggg     2640

gctgctggcc aagctgctgt ctcagctgca gcgcttcgat cgcacccacc ggtgcccctt     2700

cccccatgtg gtgcgagctg gcgccatctt cgtgcccatt cacctggtga aggagcggct     2760

cttccctcgg ctgccacccg cttctgtgga ccatgtgctg caggagcatc gtgtggagct     2820

gcggcccacc acgctgtcgg aggagcgggc actgcgggag ctcgccctgc caggctgcac     2880

ctcacgcatg ctgaagttac tggcgctgcg ccagctgccg gacatttacc ccgaccttct     2940

cggcctgcag tggcgcgact gtgtacgccg ccagctgggt gactttgaca ctgaggctgg     3000

agctgtgtcc tcctcagagc ccactgtggc cagagatgag ccagagagcc tagccctggc     3060

tcagaagtca ccggccccca aggtcaggaa gccaggcagg aagccaccaa cccctggccc     3120

ggagaaagca gaggcagctg ctggggaaga gtcctgtggt gcctccccta cccctgctac     3180

cagtgccagc ccacctggcc ccacactgaa ggcccgcttc cgcagtctgc tggagaccgc     3240

ctggctcaat ggcctggctc tgcccacctg gggccacaag tcctcaagac cagaccagcc     3300

ctcaccctgc ccacagctgc tggacagcca gagccatcac ctgtagcact ggttgccagt     3360

gctgtgtgta tagcagtcac tctccaccct tcccttctgc ctgcccagct gccccggggc     3420

cacgagtgga tgctggggct gtggctgctc ccctggaggg gttccatctc tgaccctgtg     3480

gcccattcag ggtgggctga agagcccctg agcttttaac gtgagggtct ttattggata     3540

ggactactcc ctatttcttg cctagagaac acacatgggc tttggagccc gacagacctg     3600

ggcttgaatc ccggctcgtg ttcttgctgc aggacctggg caagaaactt cacctctgct     3660

gagccctcat tccccatgtg taaaatggga caacgcaacc tacctcacag ggttgttgtg     3720

gggatgctgc ctgatacata ccctgtcccc aaaaaaaaaa aaaaaaaaaa aaaaa          3775


<210>  662
<211>  1047
<212>  PRT
<213>  Homo sapiens

<400>  662

Met Ala Glu Lys Arg Pro Leu Arg Thr Leu Gly Pro Val Met Tyr Gly 
1               5                   10                  15      


Lys Leu Pro Arg Leu Glu Thr Asp Ser Gly Leu Glu His Ser Leu Pro 
            20                  25                  30          


His Ser Val Gly Asn Gln Asp Pro Cys Thr Tyr Lys Gly Ser Tyr Phe 
        35                  40                  45              


Ser Cys Pro Met Ala Gly Thr Pro Lys Ala Glu Ser Glu Gln Leu Ala 
    50                  55                  60                  


Ser Trp Thr Pro Tyr Pro Pro Leu Tyr Ser Thr Gly Met Ala Gly Pro 
65                  70                  75                  80  


Pro Leu Gln Ala Asp Asn Leu Leu Thr Asn Cys Leu Phe Tyr Arg Ser 
                85                  90                  95      


Pro Ala Glu Gly Pro Glu Lys Met Gln Asp Ser Ser Pro Val Glu Leu 
            100                 105                 110         


Leu Pro Phe Ser Pro Gln Ala His Ser Tyr Pro Gly Pro Pro Leu Ala 
        115                 120                 125             


Ala Pro Lys Pro Val Tyr Arg Asn Pro Leu Cys Tyr Gly Leu Ser Thr 
    130                 135                 140                 


Cys Leu Gly Glu Gly Ala Val Lys Arg Pro Leu Asp Val Asp Trp Thr 
145                 150                 155                 160 


Leu Ala Thr Gly Pro Leu Leu Pro Ser Ala Asp Pro Pro Cys Ser Leu 
                165                 170                 175     


Ala Pro Ala Pro Ser Lys Gly Gln Thr Leu Asp Gly Thr Phe Leu Arg 
            180                 185                 190         


Gly Val Pro Ala Glu Gly Ser Ser Lys Asp Ser Ser Gly Ser Phe Ser 
        195                 200                 205             


Pro Cys Gln Pro Phe Leu Glu Lys Tyr Gln Thr Ile His Ser Thr Gly 
    210                 215                 220                 


Phe Leu Ala Ser Arg Tyr Thr Gly Pro Tyr Pro Arg Asn Ser Lys Gln 
225                 230                 235                 240 


Ala Met Ser Glu Gly Pro Ser Ser Pro Trp Thr Gln Leu Ala Gln Pro 
                245                 250                 255     


Leu Gly Pro Pro Cys Gln Asp Thr Gly Pro Thr His Tyr Pro Pro Pro 
            260                 265                 270         


His His Pro Pro Pro His Pro Pro Gln Ala Leu Pro Cys Pro Pro Ala 
        275                 280                 285             


Cys Arg His Pro Glu Lys Gln Gly Ser Tyr Ser Pro Ala Leu Pro Leu 
    290                 295                 300                 


Gln Pro Leu Gly Gly His Lys Gly Thr Gly Tyr Gln Ala Gly Gly Leu 
305                 310                 315                 320 


Gly Ser Pro Tyr Leu Arg Gln Gln Ala Ala Gln Ala Pro Tyr Ile Pro 
                325                 330                 335     


Pro Leu Gly Leu Asp Ala Tyr Pro Tyr Pro Ser Ala Pro Leu Pro Ala 
            340                 345                 350         


Pro Ser Pro Gly Leu Lys Leu Glu Pro Pro Leu Thr Pro Arg Cys Pro 
        355                 360                 365             


Leu Asp Phe Ala Pro Gln Thr Leu Ser Phe Pro Tyr Ala Arg Asp Asp 
    370                 375                 380                 


Leu Ser Leu Tyr Gly Ala Ser Pro Gly Leu Gly Gly Thr Pro Pro Ser 
385                 390                 395                 400 


Gln Asn Asn Val Arg Ala Val Pro Gln Pro Gly Ala Phe Gln Arg Ala 
                405                 410                 415     


Cys Gln Pro Leu Pro Ala Ser Gln Pro Cys Ser Glu Pro Val Arg Pro 
            420                 425                 430         


Ala Gln Glu Ala Glu Glu Lys Thr Trp Leu Pro Ser Cys Arg Lys Glu 
        435                 440                 445             


Lys Leu Gln Pro Arg Leu Ser Glu His Ser Gly Pro Pro Ile Val Ile 
    450                 455                 460                 


Arg Asp Ser Pro Val Pro Cys Thr Pro Pro Ala Leu Pro Pro Cys Ala 
465                 470                 475                 480 


Arg Glu Cys Gln Ser Leu Pro Gln Lys Glu Gly Ala Arg Pro Pro Ser 
                485                 490                 495     


Ser Pro Pro Met Pro Val Ile Asp Asn Val Phe Ser Leu Ala Pro Tyr 
            500                 505                 510         


Arg Asp Tyr Leu Asp Val Pro Ala Pro Glu Ala Thr Thr Glu Pro Asp 
        515                 520                 525             


Ser Ala Thr Ala Glu Pro Asp Ser Ala Pro Ala Thr Ser Glu Gly Gln 
    530                 535                 540                 


Asp Lys Gly Cys Arg Gly Thr Leu Pro Ala Gln Glu Gly Pro Ser Gly 
545                 550                 555                 560 


Ser Lys Pro Leu Arg Gly Ser Leu Lys Glu Glu Val Ala Leu Asp Leu 
                565                 570                 575     


Ser Val Arg Lys Pro Thr Ala Glu Ala Ser Pro Val Lys Ala Ser Arg 
            580                 585                 590         


Ser Val Glu His Ala Lys Pro Thr Ala Ala Met Asp Val Pro Asp Val 
        595                 600                 605             


Gly Asn Met Val Ser Asp Leu Pro Gly Leu Lys Lys Ile Asp Thr Glu 
    610                 615                 620                 


Ala Pro Gly Leu Pro Gly Val Pro Val Thr Thr Asp Ala Met Pro Arg 
625                 630                 635                 640 


Thr Asn Phe His Ser Ser Val Ala Phe Met Phe Arg Lys Phe Lys Ile 
                645                 650                 655     


Leu Arg Pro Ala Pro Leu Pro Ala Ala Val Val Pro Ser Thr Pro Thr 
            660                 665                 670         


Ser Ala Pro Ala Pro Thr Gln Pro Ala Pro Thr Pro Thr Ser Gly Pro 
        675                 680                 685             


Ile Gly Leu Arg Ile Leu Ala Gln Gln Pro Leu Ser Val Thr Cys Phe 
    690                 695                 700                 


Ser Leu Ala Leu Pro Ser Pro Pro Ala Val Ala Val Ala Ser Pro Ala 
705                 710                 715                 720 


Pro Ala Pro Ala Pro Ser Pro Ala Pro Ala Arg Ala Gln Ala Pro Ala 
                725                 730                 735     


Ser Ala Arg Asp Pro Ala Pro Ala Pro Ala Pro Val Ala Gly Pro Ala 
            740                 745                 750         


Pro Ala Ser Thr Ser Ala Pro Gly Asp Ser Leu Glu Gln His Phe Thr 
        755                 760                 765             


Gly Leu His Ala Ser Leu Cys Asp Ala Ile Ser Gly Ser Val Ala His 
    770                 775                 780                 


Ser Pro Pro Glu Lys Leu Arg Glu Trp Leu Glu Thr Ala Gly Pro Trp 
785                 790                 795                 800 


Gly Gln Ala Ala Trp Gln Asp Cys Gln Gly Val Gln Gly Leu Leu Ala 
                805                 810                 815     


Lys Leu Leu Ser Gln Leu Gln Arg Phe Asp Arg Thr His Arg Cys Pro 
            820                 825                 830         


Phe Pro His Val Val Arg Ala Gly Ala Ile Phe Val Pro Ile His Leu 
        835                 840                 845             


Val Lys Glu Arg Leu Phe Pro Arg Leu Pro Pro Ala Ser Val Asp His 
    850                 855                 860                 


Val Leu Gln Glu His Arg Val Glu Leu Arg Pro Thr Thr Leu Ser Glu 
865                 870                 875                 880 


Glu Arg Ala Leu Arg Glu Leu Ala Leu Pro Gly Cys Thr Ser Arg Met 
                885                 890                 895     


Leu Lys Leu Leu Ala Leu Arg Gln Leu Pro Asp Ile Tyr Pro Asp Leu 
            900                 905                 910         


Leu Gly Leu Gln Trp Arg Asp Cys Val Arg Arg Gln Leu Gly Asp Phe 
        915                 920                 925             


Asp Thr Glu Ala Gly Ala Val Ser Ser Ser Glu Pro Thr Val Ala Arg 
    930                 935                 940                 


Gly Glu Pro Glu Ser Leu Ala Leu Ala Gln Lys Ser Pro Ala Pro Lys 
945                 950                 955                 960 


Val Arg Lys Pro Gly Arg Lys Pro Pro Thr Pro Gly Pro Glu Lys Ala 
                965                 970                 975     


Glu Ala Ala Ala Gly Glu Glu Ser Cys Gly Ala Ser Pro Thr Pro Ala 
            980                 985                 990         


Thr Ser Ala Ser Pro Pro Gly Pro  Thr Leu Lys Ala Arg  Phe Arg Ser 
        995                 1000                 1005             


Leu Leu  Glu Thr Ala Trp Leu  Asn Gly Leu Ala Leu  Pro Thr Trp 
    1010                 1015                 1020             


Gly His  Lys Ser Ser Arg Pro  Asp Gln Pro Ser Pro  Cys Pro Gln 
    1025                 1030                 1035             


Leu Leu  Asp Ser Gln Ser His  His Leu 
    1040                 1045         


<210>  663
<211>  445
<212>  PRT
<213>  Homo sapiens

<400>  663

Met Asp Val Pro Asp Val Gly Asn Met Val Ser Asp Leu Pro Gly Leu 
1               5                   10                  15      


Lys Lys Ile Asp Thr Glu Ala Pro Gly Leu Pro Gly Val Pro Val Thr 
            20                  25                  30          


Thr Asp Ala Met Pro Arg Thr Asn Phe His Ser Ser Val Ala Phe Met 
        35                  40                  45              


Phe Arg Lys Phe Lys Ile Leu Arg Pro Ala Pro Leu Pro Ala Ala Val 
    50                  55                  60                  


Val Pro Ser Thr Pro Thr Ser Ala Pro Ala Pro Thr Gln Pro Ala Pro 
65                  70                  75                  80  


Thr Pro Thr Ser Gly Pro Ile Gly Leu Arg Ile Leu Ala Gln Gln Pro 
                85                  90                  95      


Leu Ser Val Thr Cys Phe Ser Leu Ala Leu Pro Ser Pro Pro Ala Val 
            100                 105                 110         


Ala Val Ala Ser Pro Ala Pro Ala Pro Ala Pro Ser Pro Ala Pro Ala 
        115                 120                 125             


Arg Ala Gln Ala Pro Ala Ser Ala Arg Asp Pro Ala Pro Ala Pro Ala 
    130                 135                 140                 


Pro Val Ala Gly Pro Ala Pro Ala Ser Thr Ser Ala Pro Gly Asp Ser 
145                 150                 155                 160 


Leu Glu Gln His Phe Thr Gly Leu His Ala Ser Leu Cys Asp Ala Ile 
                165                 170                 175     


Ser Gly Ser Val Ala His Ser Pro Pro Glu Lys Leu Arg Glu Trp Leu 
            180                 185                 190         


Glu Thr Ala Gly Pro Trp Gly Gln Ala Ala Trp Gln Asp Cys Gln Gly 
        195                 200                 205             


Val Gln Gly Leu Leu Ala Lys Leu Leu Ser Gln Leu Gln Arg Phe Asp 
    210                 215                 220                 


Arg Thr His Arg Cys Pro Phe Pro His Val Val Arg Ala Gly Ala Ile 
225                 230                 235                 240 


Phe Val Pro Ile His Leu Val Lys Glu Arg Leu Phe Pro Arg Leu Pro 
                245                 250                 255     


Pro Ala Ser Val Asp His Val Leu Gln Glu His Arg Val Glu Leu Arg 
            260                 265                 270         


Pro Thr Thr Leu Ser Glu Glu Arg Ala Leu Arg Glu Leu Ala Leu Pro 
        275                 280                 285             


Gly Cys Thr Ser Arg Met Leu Lys Leu Leu Ala Leu Arg Gln Leu Pro 
    290                 295                 300                 


Asp Ile Tyr Pro Asp Leu Leu Gly Leu Gln Trp Arg Asp Cys Val Arg 
305                 310                 315                 320 


Arg Gln Leu Gly Asp Phe Asp Thr Glu Ala Gly Ala Val Ser Ser Ser 
                325                 330                 335     


Glu Pro Thr Val Ala Arg Asp Glu Pro Glu Ser Leu Ala Leu Ala Gln 
            340                 345                 350         


Lys Ser Pro Ala Pro Lys Val Arg Lys Pro Gly Arg Lys Pro Pro Thr 
        355                 360                 365             


Pro Gly Pro Glu Lys Ala Glu Ala Ala Ala Gly Glu Glu Ser Cys Gly 
    370                 375                 380                 


Ala Ser Pro Thr Pro Ala Thr Ser Ala Ser Pro Pro Gly Pro Thr Leu 
385                 390                 395                 400 


Lys Ala Arg Phe Arg Ser Leu Leu Glu Thr Ala Trp Leu Asn Gly Leu 
                405                 410                 415     


Ala Leu Pro Thr Trp Gly His Lys Ser Ser Arg Pro Asp Gln Pro Ser 
            420                 425                 430         


Pro Cys Pro Gln Leu Leu Asp Ser Gln Ser His His Leu 
        435                 440                 445 


<210>  664
<211>  1123
<212>  DNA
<213>  Homo sapiens

<400>  664
cgcggtcgcg agccatggag gaggaggcat cgtccccggg gctgggctgc agcaagccgc       60

acctggagaa gctgaccctg ggcatcacgc gcatcctaga atcttcccca ggtgtgactg      120

aggtgaccat catagaaaag cctcctgctg aacgtcatat gatttcttcc tgggaacaaa      180

agaataactg tgtgatgcct gaagatgtga agaactttta cctgatgacc aatggcttcc      240

acatgacatg gagtgtgaag ctggatgagc acatcattcc actgggaagc atggcaatta      300

acagcatctc aaaactgact cagctcaccc agtcttccat gtattcactt cctaatgcac      360

ccactctggc agacctggag gacgatacac atgaagccag tgatgatcag ccagagaagc      420

ctcactttga ctctcgcagt gtgatatttg agctggattc atgcaatggc agtgggaaag      480

tttgccttgt ctacaaaagt gggaaaccag cattagcaga agacactgag atctggttcc      540

tggacagagc gttatactgg cattttctca cagacacctt tactgcctat taccgcctgc      600

tcatcaccca cctgggcctg ccccagtggc aatatgcctt caccagctat ggcattagcc      660

cacaggccaa ggtaagggag gaacacctgc cattgtaaac tatggtatat tccaaaatct      720

actgaggaaa tggttacatt gcaggttccc aacttcccta tctgattcag gagatctagg      780

gtggggccca ggaacctgca ttttcaataa gcaagacaga tgattccaat ggacagcctc      840

actttactca tctagttaag tggttcccaa acttgactga ttctcagaat taactgggga      900

gttttatttt taatgaaatt ctgttggata gtttatgtcc catgacttgt tctgggttgg      960

cagtacatgc acccaggaag agtgaaaagt cagattctca ctcccctgtt ctccaagtgt     1020

gcatccccag tggcagctgc tattacgagt ttcctgtacg cccttcccaa gatactcatt     1080

gcacataaag catgcatgca caaaaaaaaa aaaaaaaaaa aaa                       1123


<210>  665
<211>  300
<212>  PRT
<213>  Homo sapiens

<400>  665

Met Glu Glu Glu Ala Ser Ser Pro Gly Leu Gly Cys Ser Lys Pro His 
1               5                   10                  15      


Leu Glu Lys Leu Thr Leu Gly Ile Thr Arg Ile Leu Glu Ser Ser Pro 
            20                  25                  30          


Gly Val Thr Glu Val Thr Ile Ile Glu Lys Pro Pro Ala Glu Arg His 
        35                  40                  45              


Met Ile Ser Ser Trp Glu Gln Lys Asn Asn Cys Val Met Pro Glu Asp 
    50                  55                  60                  


Val Lys Asn Phe Tyr Leu Met Thr Asn Gly Phe His Met Thr Trp Ser 
65                  70                  75                  80  


Val Lys Leu Asp Glu His Ile Ile Pro Leu Gly Ser Met Ala Ile Asn 
                85                  90                  95      


Ser Ile Ser Lys Leu Thr Gln Leu Thr Gln Ser Ser Met Tyr Ser Leu 
            100                 105                 110         


Pro Asn Ala Pro Thr Leu Ala Asp Leu Glu Asp Asp Thr His Glu Ala 
        115                 120                 125             


Ser Asp Asp Gln Pro Glu Lys Pro His Phe Asp Ser Arg Ser Val Ile 
    130                 135                 140                 


Phe Glu Leu Asp Ser Cys Asn Gly Ser Gly Lys Val Cys Leu Val Tyr 
145                 150                 155                 160 


Lys Ser Gly Lys Pro Ala Leu Ala Glu Asp Thr Glu Ile Trp Phe Leu 
                165                 170                 175     


Asp Arg Ala Leu Tyr Trp His Phe Leu Thr Asp Thr Phe Thr Ala Tyr 
            180                 185                 190         


Tyr Arg Leu Leu Ile Thr His Leu Gly Leu Pro Gln Trp Gln Tyr Ala 
        195                 200                 205             


Phe Thr Ser Tyr Gly Ile Ser Pro Gln Ala Lys Gln Trp Phe Ser Met 
    210                 215                 220                 


Tyr Lys Pro Ile Thr Tyr Asn Thr Asn Leu Leu Thr Glu Glu Thr Asp 
225                 230                 235                 240 


Ser Phe Val Asn Lys Leu Asp Pro Ser Lys Val Phe Lys Ser Lys Asn 
                245                 250                 255     


Lys Ile Val Ile Pro Lys Lys Lys Gly Pro Val Gln Pro Ala Gly Gly 
            260                 265                 270         


Gln Lys Gly Pro Ser Gly Pro Ser Gly Pro Ser Thr Ser Ser Thr Ser 
        275                 280                 285             


Lys Ser Ser Ser Gly Ser Gly Asn Pro Thr Arg Lys 
    290                 295                 300 


<210>  666
<211>  167
<212>  PRT
<213>  Homo sapiens

<400>  666

Met Pro Glu Asp Val Lys Asn Phe Tyr Leu Met Thr Asn Gly Phe His 
1               5                   10                  15      


Met Thr Trp Ser Val Lys Leu Asp Glu His Ile Ile Pro Leu Gly Ser 
            20                  25                  30          


Met Ala Ile Asn Ser Ile Ser Lys Leu Thr Gln Leu Thr Gln Ser Ser 
        35                  40                  45              


Met Tyr Ser Leu Pro Asn Ala Pro Thr Leu Ala Asp Leu Glu Asp Asp 
    50                  55                  60                  


Thr His Glu Ala Ser Asp Asp Gln Pro Glu Lys Pro His Phe Asp Ser 
65                  70                  75                  80  


Arg Ser Val Ile Phe Glu Leu Asp Ser Cys Asn Gly Ser Gly Lys Val 
                85                  90                  95      


Cys Leu Val Tyr Lys Ser Gly Lys Pro Ala Leu Ala Glu Asp Thr Glu 
            100                 105                 110         


Ile Trp Phe Leu Asp Arg Ala Leu Tyr Trp His Phe Leu Thr Asp Thr 
        115                 120                 125             


Phe Thr Ala Tyr Tyr Arg Leu Leu Ile Thr His Leu Gly Leu Pro Gln 
    130                 135                 140                 


Trp Gln Tyr Ala Phe Thr Ser Tyr Gly Ile Ser Pro Gln Ala Lys Val 
145                 150                 155                 160 


Arg Glu Glu His Leu Pro Leu 
                165         


<210>  667
<211>  2142
<212>  DNA
<213>  Homo sapiens

<400>  667
ccgggctcca ccgcgcatcc tgctccactc tggcgaccgc ccccggggcc cccgccgcgg       60

gcgcggcgcc cgccatgggc gaggaggact actatctgga gctgtgcgag cggccggtgc      120

agttcgagaa ggcgaaccct gtcaactgcg tcttcttcga tgaggccaac aagcaggttt      180

ttgctgttcg atctggtgga gctactggcg tggtagttaa aggcccagat gataggaatc      240

ccatctcatt tagaatggat gacaaaggag aagtgaagtg cattaagttt tccttagaaa      300

ataagatatt ggctgttcag aggacctcaa agactgtgga tttttgtaat tttatccctg      360

ataattccca gctggaatac acacaggagt gcaagactaa gaatgccaac attctaggat      420

tctgctggac tagttcaact gaaattgtct tcataacaga tcaaggaatc gaattttacc      480

aggtattacc agagaaacgg agtctgaaac tcttgaagag ccacaatctc aatgtgaatt      540

ggtacatgta ctgccccgag agcgccgtga tcttgctgtc taccacggtc ctggagaatg      600

tcctgcagcc ttttcacttt agggctggca ctatgtcgaa gctgcccaaa tttgagattg      660

aattaccagc tgcgcctaag tcaactaaac ccagcctttc cgaaagagac atcgcaatgg      720

ctaccatata cgggcagctg tatgttctct tcttgaggca tcattctcgg acctccaaca      780

gcacaggagc ggaggtggtc ctctatcatc taccacgaga aggtgcctgt aaaaagatgc      840

acatattgaa gttaaatagg acgggaaagt ttgccctgaa cgtggtggac aacctggtag      900

tcgtgcatca tcaggataca gagacatcgg taatattcga tatcaagtta cggggagagt      960

ttgacggctc cgttaccttc caccaccccg tgcttcccgc tcgatcgatc cagccctatc     1020

agatccccat cacaggtcct gctgccgtga ccagccagtc tcctgttcca tgtaaactct     1080

attcttcatc ttggattgtc tttcaacctg acatcattat cagcgcaagc caaggttacc     1140

tctggaacct ccaagtgaaa cttgagccca tagtaaatct cttaccagac aaaggaagac     1200

tcatggactt tctcctccag agaaaggaat gcaagatggt catcctgtct gtctgttcac     1260

agatgttaag tgagtcagac agagcatcgc tgcccgtgat agccactgtt tttgataaac     1320

tcaaccatga gtataaaaag tacctggatg ccgagcagag ttatgcgatg gcggtggaag     1380

cagggcagag ccgaagcagc ccgctcctca agaggccggt gcggacccag gcggtgctgg     1440

accagtcaga tgtgtacacc catgtcctgt cagcctttgt ggaaaagaag gagatgcctc     1500

ataaatttgt gatagccgtg ctgatggaat acattcgttc tcttaaccag tttcagattg     1560

cagtacagca ttacctacat gaacttgtta tcaaaaccct tgtccagcac aacctctttt     1620

atatgctgca tcagttcctg cagtaccacg tcctcagcga ctccaaacct ttggcttgtc     1680

tgctgttatc cctagagagt ttctatcctc ctgctcatca gctatctctg gacatgctga     1740

agcgactttc aacagcaaat gatgaaatag tagaagttct cctttccaaa caccaagtgt     1800

tagctgcctt aaggtttatc cggggcattg gtggccatga caacatttct gcacgaaaat     1860

ttttagatgc tgcaaagcag actgaagaca acatgctttt ctatacaata ttccgctttt     1920

ttgaacagcg aaaccagcgt ttgcgaggga gccccaattt cacaccaggg gaacactgtg     1980

aagaacatgt tgcttttttc aaacagattt ttggagacca agctctaatg aggcctacaa     2040

cattctgaaa tcacttgctg tttttttata taaaaatgtg tacaaagtta atttattgca     2100

ttaataaagc tctttaaact ataaaaaaaa aaaaaaaaaa aa                        2142


<210>  668
<211>  657
<212>  PRT
<213>  Homo sapiens

<400>  668

Met Gly Glu Glu Asp Tyr Tyr Leu Glu Leu Cys Glu Arg Pro Val Gln 
1               5                   10                  15      


Phe Glu Lys Ala Asn Pro Val Asn Cys Val Phe Phe Asp Glu Ala Asn 
            20                  25                  30          


Lys Gln Val Phe Ala Val Arg Ser Gly Gly Ala Thr Gly Val Val Val 
        35                  40                  45              


Lys Gly Pro Asp Asp Arg Asn Pro Ile Ser Phe Arg Met Asp Asp Lys 
    50                  55                  60                  


Gly Glu Val Lys Cys Ile Lys Phe Ser Leu Glu Asn Lys Ile Leu Ala 
65                  70                  75                  80  


Val Gln Arg Thr Ser Lys Thr Val Asp Phe Cys Asn Phe Ile Pro Asp 
                85                  90                  95      


Asn Ser Gln Leu Glu Tyr Thr Gln Glu Cys Lys Thr Lys Asn Ala Asn 
            100                 105                 110         


Ile Leu Gly Phe Cys Trp Thr Ser Ser Thr Glu Ile Val Phe Ile Thr 
        115                 120                 125             


Asp Gln Gly Ile Glu Phe Tyr Gln Val Leu Pro Glu Lys Arg Ser Leu 
    130                 135                 140                 


Lys Leu Leu Lys Ser His Asn Leu Asn Val Asn Trp Tyr Met Tyr Cys 
145                 150                 155                 160 


Pro Glu Ser Ala Val Ile Leu Leu Ser Thr Thr Val Leu Glu Asn Val 
                165                 170                 175     


Leu Gln Pro Phe His Phe Arg Ala Gly Thr Met Ser Lys Leu Pro Lys 
            180                 185                 190         


Phe Glu Ile Glu Leu Pro Ala Ala Pro Lys Ser Thr Lys Pro Ser Leu 
        195                 200                 205             


Ser Glu Arg Asp Ile Ala Met Ala Thr Ile Tyr Gly Gln Leu Tyr Val 
    210                 215                 220                 


Leu Phe Leu Arg His His Ser Arg Thr Ser Asn Ser Thr Gly Ala Glu 
225                 230                 235                 240 


Val Val Leu Tyr His Leu Pro Arg Glu Gly Ala Cys Lys Lys Met His 
                245                 250                 255     


Ile Leu Lys Leu Asn Arg Thr Gly Lys Phe Ala Leu Asn Val Val Asp 
            260                 265                 270         


Asn Leu Val Val Val His His Gln Asp Thr Glu Thr Ser Val Ile Phe 
        275                 280                 285             


Asp Ile Lys Leu Arg Gly Glu Phe Asp Gly Ser Val Thr Phe His His 
    290                 295                 300                 


Pro Val Leu Pro Ala Arg Ser Ile Gln Pro Tyr Gln Ile Pro Ile Thr 
305                 310                 315                 320 


Gly Pro Ala Ala Val Thr Ser Gln Ser Pro Val Pro Cys Lys Leu Tyr 
                325                 330                 335     


Ser Ser Ser Trp Ile Val Phe Gln Pro Asp Ile Ile Ile Ser Ala Ser 
            340                 345                 350         


Gln Gly Tyr Leu Trp Asn Leu Gln Val Lys Leu Glu Pro Ile Val Asn 
        355                 360                 365             


Leu Leu Pro Asp Lys Gly Arg Leu Met Asp Phe Leu Leu Gln Arg Lys 
    370                 375                 380                 


Glu Cys Lys Met Val Ile Leu Ser Val Cys Ser Gln Met Leu Ser Glu 
385                 390                 395                 400 


Ser Asp Arg Ala Ser Leu Pro Val Ile Ala Thr Val Phe Asp Lys Leu 
                405                 410                 415     


Asn His Glu Tyr Lys Lys Tyr Leu Asp Ala Glu Gln Ser Tyr Ala Met 
            420                 425                 430         


Ala Val Glu Ala Gly Gln Ser Arg Ser Ser Pro Leu Leu Lys Arg Pro 
        435                 440                 445             


Val Arg Thr Gln Ala Val Leu Asp Gln Ser Asp Val Tyr Thr His Val 
    450                 455                 460                 


Leu Ser Ala Phe Val Glu Lys Lys Glu Met Pro His Lys Phe Val Ile 
465                 470                 475                 480 


Ala Val Leu Met Glu Tyr Ile Arg Ser Leu Asn Gln Phe Gln Ile Ala 
                485                 490                 495     


Val Gln His Tyr Leu His Glu Leu Val Ile Lys Thr Leu Val Gln His 
            500                 505                 510         


Asn Leu Phe Tyr Met Leu His Gln Phe Leu Gln Tyr His Val Leu Ser 
        515                 520                 525             


Asp Ser Lys Pro Leu Ala Cys Leu Leu Leu Ser Leu Glu Ser Phe Tyr 
    530                 535                 540                 


Pro Pro Ala His Gln Leu Ser Leu Asp Met Leu Lys Arg Leu Ser Thr 
545                 550                 555                 560 


Ala Asn Asp Glu Ile Val Glu Val Leu Leu Ser Lys His Gln Val Leu 
                565                 570                 575     


Ala Ala Leu Arg Phe Ile Arg Gly Ile Gly Gly His Asp Asn Ile Ser 
            580                 585                 590         


Ala Arg Lys Phe Leu Asp Ala Ala Lys Gln Thr Glu Asp Asn Met Leu 
        595                 600                 605             


Phe Tyr Thr Ile Phe Arg Phe Phe Glu Gln Arg Asn Gln Arg Leu Arg 
    610                 615                 620                 


Gly Ser Pro Asn Phe Thr Pro Gly Glu His Cys Glu Glu His Val Ala 
625                 630                 635                 640 


Phe Phe Lys Gln Ile Phe Gly Asp Gln Ala Leu Met Arg Pro Thr Thr 
                645                 650                 655     


Phe 
    


<210>  669
<211>  657
<212>  PRT
<213>  Homo sapiens

<400>  669

Met Gly Glu Glu Asp Tyr Tyr Leu Glu Leu Cys Glu Arg Pro Val Gln 
1               5                   10                  15      


Phe Glu Lys Ala Asn Pro Val Asn Cys Val Phe Phe Asp Glu Ala Asn 
            20                  25                  30          


Lys Gln Val Phe Ala Val Arg Ser Gly Gly Ala Thr Gly Val Val Val 
        35                  40                  45              


Lys Gly Pro Asp Asp Arg Asn Pro Ile Ser Phe Arg Met Asp Asp Lys 
    50                  55                  60                  


Gly Glu Val Lys Cys Ile Lys Phe Ser Leu Glu Asn Lys Ile Leu Ala 
65                  70                  75                  80  


Val Gln Arg Thr Ser Lys Thr Val Asp Phe Cys Asn Phe Ile Pro Asp 
                85                  90                  95      


Asn Ser Gln Leu Glu Tyr Thr Gln Glu Cys Lys Thr Lys Asn Ala Asn 
            100                 105                 110         


Ile Leu Gly Phe Cys Trp Thr Ser Ser Thr Glu Ile Val Phe Ile Thr 
        115                 120                 125             


Asp Gln Gly Ile Glu Phe Tyr Gln Val Leu Pro Glu Lys Arg Ser Leu 
    130                 135                 140                 


Lys Leu Leu Lys Ser His Asn Leu Asn Val Asn Trp Tyr Met Tyr Cys 
145                 150                 155                 160 


Pro Glu Ser Ala Val Ile Leu Leu Ser Thr Thr Val Leu Glu Asn Val 
                165                 170                 175     


Leu Gln Pro Phe His Phe Arg Ala Gly Thr Met Ser Lys Leu Pro Lys 
            180                 185                 190         


Phe Glu Ile Glu Leu Pro Ala Ala Pro Lys Ser Thr Lys Pro Ser Leu 
        195                 200                 205             


Ser Glu Arg Asp Ile Ala Met Ala Thr Ile Tyr Gly Gln Leu Tyr Val 
    210                 215                 220                 


Leu Phe Leu Arg His His Ser Arg Thr Ser Asn Ser Thr Gly Ala Glu 
225                 230                 235                 240 


Val Val Leu Tyr His Leu Pro Arg Glu Gly Ala Cys Lys Lys Met His 
                245                 250                 255     


Ile Leu Lys Leu Asn Arg Thr Gly Lys Phe Ala Leu Asn Val Val Asp 
            260                 265                 270         


Asn Leu Val Val Val His His Gln Asp Thr Glu Thr Ser Val Ile Phe 
        275                 280                 285             


Asp Ile Lys Leu Arg Gly Glu Phe Asp Gly Ser Val Thr Phe His His 
    290                 295                 300                 


Pro Val Leu Pro Ala Arg Ser Ile Gln Pro Tyr Gln Ile Pro Ile Thr 
305                 310                 315                 320 


Gly Pro Ala Ala Val Thr Ser Gln Ser Pro Val Pro Cys Lys Leu Tyr 
                325                 330                 335     


Ser Ser Ser Trp Ile Val Phe Gln Pro Asp Ile Ile Ile Ser Ala Ser 
            340                 345                 350         


Gln Gly Tyr Leu Trp Asn Leu Gln Val Lys Leu Glu Pro Ile Val Asn 
        355                 360                 365             


Leu Leu Pro Asp Lys Gly Arg Leu Met Asp Phe Leu Leu Gln Arg Lys 
    370                 375                 380                 


Glu Cys Lys Met Val Ile Leu Ser Val Cys Ser Gln Met Leu Ser Glu 
385                 390                 395                 400 


Ser Asp Arg Ala Ser Leu Pro Val Ile Ala Thr Val Phe Asp Lys Leu 
                405                 410                 415     


Asn His Glu Tyr Lys Lys Tyr Leu Asp Ala Glu Gln Ser Tyr Ala Met 
            420                 425                 430         


Ala Val Glu Ala Gly Gln Ser Arg Ser Ser Pro Leu Leu Lys Arg Pro 
        435                 440                 445             


Val Arg Thr Gln Ala Val Leu Asp Gln Ser Asp Val Tyr Thr His Val 
    450                 455                 460                 


Leu Ser Ala Phe Val Glu Lys Lys Glu Met Pro His Lys Phe Val Ile 
465                 470                 475                 480 


Ala Val Leu Met Glu Tyr Ile Arg Ser Leu Asn Gln Phe Gln Ile Ala 
                485                 490                 495     


Val Gln His Tyr Leu His Glu Leu Val Ile Lys Thr Leu Val Gln His 
            500                 505                 510         


Asn Leu Phe Tyr Met Leu His Gln Phe Leu Gln Tyr His Val Leu Ser 
        515                 520                 525             


Asp Ser Lys Pro Leu Ala Cys Leu Leu Leu Ser Leu Glu Ser Phe Tyr 
    530                 535                 540                 


Pro Pro Ala His Gln Leu Ser Leu Asp Met Leu Lys Arg Leu Ser Thr 
545                 550                 555                 560 


Ala Asn Asp Glu Ile Val Glu Val Leu Leu Ser Lys His Gln Val Leu 
                565                 570                 575     


Ala Ala Leu Arg Phe Ile Arg Gly Ile Gly Gly His Asp Asn Ile Ser 
            580                 585                 590         


Ala Arg Lys Phe Leu Asp Ala Ala Lys Gln Thr Glu Asp Asn Met Leu 
        595                 600                 605             


Phe Tyr Thr Ile Phe Arg Phe Phe Glu Gln Arg Asn Gln Arg Leu Arg 
    610                 615                 620                 


Gly Ser Pro Asn Phe Thr Pro Gly Glu His Cys Glu Glu His Val Ala 
625                 630                 635                 640 


Phe Phe Lys Gln Ile Phe Gly Asp Gln Ala Leu Met Arg Pro Thr Thr 
                645                 650                 655     


Phe 
    


<210>  670
<211>  1254
<212>  DNA
<213>  Homo sapiens

<400>  670
cggagacgct gaggcgggtg ctaaccaggg gcggtgcggc ctggtccggg gaggagaaca       60

tgcctgccgc cggaccgcct ttgctgctgc tcggtacacc aggatctgga aaaacagcgc      120

tgctatttgc tgcggcccta gaggcggcgg gggagggcca aggcccagtc ctcttcctga      180

cacgaaggcc tcttcaaagc atgccccgcg ggaccggaac gactctagac ccaatgcgac      240

tccagaagat ccgcttccag tacccaccct caacccgaga gcttttccgg ctcctgtgct      300

ctgcccatga ggccccgggg ccagccccct cccttctgct gctcgacggc ctagaagagt      360

acctagcgga agacccagag ccccaggaag ccgcctacct cattgcctta cttctagaca      420

cagctgccca cttcagccac cggcttgggc ctggccggga ttgtgggctc atggtggccc      480

tccagaccca ggaggaagca ggtagtgggg acgtcctgca tctggcactg ctccagcggt      540

attttcctgc ccagtgctgg ctgcagccag atgcaccagg tccaggagag cacggcctcc      600

gagcctgcct ggagccaggc gggctgggcc ccagaacaga gtggtgggtg actttccgat      660

cagatggaga aatgatgatc gctccgtggc ccacccaggc tggtgacccc agctcaggca      720

agggttcaag ctctggaggc cagccctgag ctttggtggg tgactacctc tctgtgcttc      780

agtttcccat ggctggaata cttacctcag ggacatatgc agatccaaag acctaaacaa      840

tgtaaagtgc tttttctctt ttaaaagtat agcattatct tgtatatatt ttacccaatc      900

aatatgttgt ttatagtttc attgctttaa actttataaa aagagcttca ggccaggcgt      960

ggtggctcac gcctgtaatc ccagcacttt gggaggctga ggcggtcaga tcaccagagg     1020

tcaggagttg gagaccagcc tgcccaacat gatgaaaccc tgtatcaact aaaagtacaa     1080

aaaaaattag ctgggtgtgg tggcaggtgc ctgtagtctc agctactcag gaggcttagg     1140

caggagaatt gcttgaaccc aggaagcgga ggttgcagtg agccgagatt gtgccactac     1200

actccagcct gggtgacaaa gcgagactcc atctcaaaaa aaaaaaaaaa aaaa           1254


<210>  671
<211>  229
<212>  PRT
<213>  Homo sapiens

<400>  671

Met Pro Ala Ala Gly Pro Pro Leu Leu Leu Leu Gly Thr Pro Gly Ser 
1               5                   10                  15      


Gly Lys Thr Ala Leu Leu Phe Ala Ala Ala Leu Glu Ala Ala Gly Glu 
            20                  25                  30          


Gly Gln Gly Pro Val Leu Phe Leu Thr Arg Arg Pro Leu Gln Ser Met 
        35                  40                  45              


Pro Arg Gly Thr Gly Thr Thr Leu Asp Pro Met Arg Leu Gln Lys Ile 
    50                  55                  60                  


Arg Phe Gln Tyr Pro Pro Ser Thr Arg Glu Leu Phe Arg Leu Leu Cys 
65                  70                  75                  80  


Ser Ala His Glu Ala Pro Gly Pro Ala Pro Ser Leu Leu Leu Leu Asp 
                85                  90                  95      


Gly Leu Glu Glu Tyr Leu Ala Glu Asp Pro Glu Pro Gln Glu Ala Ala 
            100                 105                 110         


Tyr Leu Ile Ala Leu Leu Leu Asp Thr Ala Ala His Phe Ser His Arg 
        115                 120                 125             


Leu Gly Pro Gly Arg Asp Cys Gly Leu Met Val Ala Leu Gln Thr Gln 
    130                 135                 140                 


Glu Glu Ala Gly Ser Gly Asp Val Leu His Leu Ala Leu Leu Gln Arg 
145                 150                 155                 160 


Tyr Phe Pro Ala Gln Cys Trp Leu Gln Pro Asp Ala Pro Gly Pro Gly 
                165                 170                 175     


Glu His Gly Leu Arg Ala Cys Leu Glu Pro Gly Gly Leu Gly Pro Arg 
            180                 185                 190         


Thr Glu Trp Trp Val Thr Phe Arg Ser Asp Gly Glu Met Met Ile Ala 
        195                 200                 205             


Pro Trp Pro Thr Gln Ala Gly Asp Pro Ser Ser Gly Lys Gly Ser Ser 
    210                 215                 220                 


Ser Gly Gly Gln Pro 
225                 


<210>  672
<211>  229
<212>  PRT
<213>  Homo sapiens

<400>  672

Met Pro Ala Ala Gly Pro Pro Leu Leu Leu Leu Gly Thr Pro Gly Ser 
1               5                   10                  15      


Gly Lys Thr Ala Leu Leu Phe Ala Ala Ala Leu Glu Ala Ala Gly Glu 
            20                  25                  30          


Gly Gln Gly Pro Val Leu Phe Leu Thr Arg Arg Pro Leu Gln Ser Met 
        35                  40                  45              


Pro Arg Gly Thr Gly Thr Thr Leu Asp Pro Met Arg Leu Gln Lys Ile 
    50                  55                  60                  


Arg Phe Gln Tyr Pro Pro Ser Thr Arg Glu Leu Phe Arg Leu Leu Cys 
65                  70                  75                  80  


Ser Ala His Glu Ala Pro Gly Pro Ala Pro Ser Leu Leu Leu Leu Asp 
                85                  90                  95      


Gly Leu Glu Glu Tyr Leu Ala Glu Asp Pro Glu Pro Gln Glu Ala Ala 
            100                 105                 110         


Tyr Leu Ile Ala Leu Leu Leu Asp Thr Ala Ala His Phe Ser His Arg 
        115                 120                 125             


Leu Gly Pro Gly Arg Asp Cys Gly Leu Met Val Ala Leu Gln Thr Gln 
    130                 135                 140                 


Glu Glu Ala Gly Ser Gly Asp Val Leu His Leu Ala Leu Leu Gln Arg 
145                 150                 155                 160 


Tyr Phe Pro Ala Gln Cys Trp Leu Gln Pro Asp Ala Pro Gly Pro Gly 
                165                 170                 175     


Glu His Gly Leu Arg Ala Cys Leu Glu Pro Gly Gly Leu Gly Pro Arg 
            180                 185                 190         


Thr Glu Trp Trp Val Thr Phe Arg Ser Asp Gly Glu Met Met Ile Ala 
        195                 200                 205             


Pro Trp Pro Thr Gln Ala Gly Asp Pro Ser Ser Gly Lys Gly Ser Ser 
    210                 215                 220                 


Ser Gly Gly Gln Pro 
225                 


<210>  673
<211>  2585
<212>  DNA
<213>  Homo sapiens

<400>  673
ctggagggct gggggcctac taggtcaggt cggctgtagg attctgctcc agggttggcg       60

gctgcttctt tctggcctgg ctgccactga gtagccgagg ggccgccgtg accctctgac      120

tgattgactg gctggctgcc tacgtcggcg ctcctcaggg ccccaagctc ctcaggccga      180

acttcggggt tggattgctc aagagttgtg ctgagaccca gaaggctaga ggctagtttc      240

gaagctgtag ctcaggctga gtctcaaggc gggcggcgac tggacggcca gaccggcgag      300

ctcttgacgg gaaggcgacc ggcagcctcg ggcaggggag acaggactgt atgtcagaga      360

agagacggcg cttggacgcc aggaatcctc tgaagcagga gactgcccta tccagaagat      420

gactcaagac cggcctctgc ttgccgtgca ggaggcgctg aagaagtgct tccccgtggt      480

ggaggagcag cagggcctgt ggcagagtgc cctgcgggac tgccagcccc tcctgtcctc      540

cctcagcaac ctggcggaac agctgcaggc cgcacagaac ctgcggtttg aggatgtgcc      600

ggcgcttcgg gccttcccag atttaaaaga gcggctgagg cagccatcct cctcaaggtg      660

cgagacatgg tcagcagcca tgtggagcga gtgtttcaga tctatgagca acacgcagac      720

acagttggca ttgatgctgt cctgcagcct tcagcagtga gcccctctgt ggctgacatg      780

ttggaatggt tgcaggatat tgagagacat tatcgaaagt cactgcattt tcttttgagc      840

agtccttaac ttccagaaag gtacctgaag agaaagtatc ttctttcgtc tatccagtgg      900

ggagacttgg caaacataca agctttgccc aaggcctggg accgaatttc aaaagacgaa      960

caccaagatc ttgtacaaga tatcctattg aatgtttcct tcttcctgga agagtaagga     1020

agctatgcgt atctggagac cacgggtacc acagttgaag actgacattc tgaaccctga     1080

tgtttctaaa gaaacgtcag tatttcagtc tgacatattt gaaacatcag tgccttgaac     1140

cttaggactg ggtcttgggg aggattagcg cctagatgtc tgattttgga gctgcagcat     1200

gccaggccgt ggctgagagt atgtgagcca tgccttgccc ttttctgagg ctcagggaag     1260

tggatggagc tagagagaca acaggaaaga cggtgctgaa gaacatagtg tctttcctct     1320

attgtggacc taaagaggtg gggaagcaag gacaagaggc aaagagccac actgcccttg     1380

gcatcatcca aagcattgtc tggttgacac caggtcctgg ttttgtgtct tttgtcaata     1440

cctgaatcct tgacaaaaga aaaagtggtt ttgatgattt aaagaaataa gggtgatttt     1500

gacagaaaat atattttaaa aattttgacc aattgcaata gttatcctca agccaatttc     1560

cagaacctgc caccaggggg aggtggtgca gcatgaatca ttctgaatgc tttgtctttg     1620

aagtgttccc ctattgctgt taccatctca gaggaagtaa ctgggcatgg tgagactcct     1680

aaaatgacag gagttttttt ggccaaagct ggcatctgac ttgccacatt cctctgagtc     1740

tggagtagcc gcaggggtgg gagaatgcca gcccagagtc agtccatcgg ggttacattt     1800

ccaaggtctg ctgccttcat ctatgtaatg gccgtgttac tttcagatct ttcagcttcc     1860

cagagtgttg tgggaatctt ggtcattgaa tgtaaaggga cttagtaaag ggtatagata     1920

tttttcaaaa atgaaaataa ctttttttct tataagtgat aagcttttat aaagatcata     1980

ggaaaactag aaaaaatgta aaatgtagaa aattgtaaaa caaacttcat tagagatatt     2040

ttgatagata ccttttcagt gtctatttac aaattttttc ttttaatata gatagggtct     2100

cactatattg cccagctcac tcctgagctc aagggatcct cccaccatag cctcccaaaa     2160

tattggaaat acaggcatga gccactgctc ctgaccaatt cacaaatttt tttaaagaac     2220

aaacgtgcta tcatcgatac atactgttag gttgtctttt tttaaaaaac ctaatgtaat     2280

ttgttcatct ttttatatct gtaaatatag ctcaacacag ttatattctt tttgtgaatg     2340

tattatatct acaatttacc ttttttctta gattttacat gcattttccc aaatctttgt     2400

gtttgcctat ctgtaaaggt aatacattct gattacaaaa aatgaaaatg ttacatagaa     2460

atgtaccgtt atccatctac cagataacta ttattaataa tgtgtattta tttttccagg     2520

aattaaaaaa catctatcat ataagtattg caaataaaac ttaaaaagca aaaaaaaaaa     2580

aaaaa                                                                 2585


<210>  674
<211>  203
<212>  PRT
<213>  Homo sapiens

<400>  674

Met Thr Gln Asp Arg Pro Leu Leu Ala Val Gln Glu Ala Leu Lys Lys 
1               5                   10                  15      


Cys Phe Pro Val Val Glu Glu Gln Gln Gly Leu Trp Gln Ser Ala Leu 
            20                  25                  30          


Arg Asp Cys Gln Pro Leu Leu Ser Ser Leu Ser Asn Leu Ala Glu Gln 
        35                  40                  45              


Leu Gln Ala Ala Gln Asn Leu Arg Phe Glu Asp Val Pro Ala Leu Arg 
    50                  55                  60                  


Ala Phe Pro Asp Leu Lys Glu Arg Leu Arg Arg Lys Gln Leu Val Ala 
65                  70                  75                  80  


Gly Asp Ile Val Leu Asp Lys Leu Gly Glu Arg Leu Ala Ile Leu Leu 
                85                  90                  95      


Lys Val Arg Asp Met Val Ser Ser His Val Glu Arg Val Phe Gln Ile 
            100                 105                 110         


Tyr Glu Gln His Ala Asp Thr Val Gly Ile Asp Ala Val Leu Gln Pro 
        115                 120                 125             


Ser Ala Val Ser Pro Ser Val Ala Asp Met Leu Glu Trp Leu Gln Asp 
    130                 135                 140                 


Ile Glu Arg His Tyr Arg Lys Ser Tyr Leu Lys Arg Lys Tyr Leu Leu 
145                 150                 155                 160 


Ser Ser Ile Gln Trp Gly Asp Leu Ala Asn Ile Gln Ala Leu Pro Lys 
                165                 170                 175     


Ala Trp Asp Arg Ile Ser Lys Asp Glu His Gln Asp Leu Val Gln Asp 
            180                 185                 190         


Ile Leu Leu Asn Val Ser Phe Phe Leu Glu Glu 
        195                 200             


<210>  675
<211>  113
<212>  PRT
<213>  Homo sapiens

<400>  675

Met Thr Gln Asp Arg Pro Leu Leu Ala Val Gln Glu Ala Leu Lys Lys 
1               5                   10                  15      


Cys Phe Pro Val Val Glu Glu Gln Gln Gly Leu Trp Gln Ser Ala Leu 
            20                  25                  30          


Arg Asp Cys Gln Pro Leu Leu Ser Ser Leu Ser Asn Leu Ala Glu Gln 
        35                  40                  45              


Leu Gln Ala Ala Gln Asn Leu Arg Phe Glu Asp Val Pro Ala Leu Arg 
    50                  55                  60                  


Ala Phe Pro Asp Leu Lys Glu Arg Leu Arg Gln Pro Ser Ser Ser Arg 
65                  70                  75                  80  


Cys Glu Thr Trp Ser Ala Ala Met Trp Ser Glu Cys Phe Arg Ser Met 
                85                  90                  95      


Ser Asn Thr Gln Thr Gln Leu Ala Leu Met Leu Ser Cys Ser Leu Gln 
            100                 105                 110         


Gln 
    


<210>  676
<211>  3092
<212>  DNA
<213>  Homo sapiens

<400>  676
gtcccccctg gaaaagggaa caatcaaaga ggaaaagacc acttaacaag ggggttggga       60

ggtagttggc cagctttgga atagctggtg agagagagaa actttcatta ccatctagtt      120

accacctgtt ctctagatgg gaaaaagaaa aaaaaagtca gtaaatactg gaagcagaca      180

gttaccagaa gtcaccccca caaaaaaata agctgggtgg tgggggtggt ggttagttgt      240

tgttgctaga agacagaaga cttactattt ggaaaccttc cccgggttcc acaggatcta      300

cgagattcta gtcagcaaag ggagcaatgc ctgtccacgt gtgtgtgaat gtatgtgttt      360

ataatgatgg cttttccttc ctccccagag tgttcatact gtggagcccg ctgggaccag      420

tataaactct gctctactcc ccagtgccgc cagctcgttt tgacctgccc tgcctgtcaa      480

ggacaaggat tcacagcctg ttgtgtcaca tgtcaagaca aggggagcag gaaagtttca      540

ggccctatgc aagacagctt taaagaggaa tgcgagtgca cagcccgacg gccacgcata      600

cctagggaac tcttgcagca tgtgcgacag cctgtgagcc cagagccagg gcctgatgct      660

gatgaggatg ggccagtgct tatgtgagca gcacctttgg cattttccca ggccctcggt      720

aaaagtaggt ttggggtgac tatacagaga aagcatggca agactgcaga aacagagaaa      780

tcgggaactt cagttctggc cgctgccacc gtggcagccg tctacacttc acagcgggag      840

gggaggagtc acgttgtcta ccacttacct gagacattct gatttggatg atgctagagc      900

acagaaaata ggtgagctgc atgggatccc aaagctgctg agggatagag cctgagcctg      960

gtggccacag catatgccct ttctgttcca tgcagctggg gctgttagta gtcattgccc     1020

ttgtcagcag accttctacc ctggtggcaa acacatgaaa gctgtggccc tgggagtggc     1080

ctcctaaaac aagccactta ggtcatctgc catctaccct taacctctgt ctctcgcctg     1140

aggggaatct gcaagctgtg cattgggctt acctcctgct tttgtagaaa taaccatcct     1200

ttggtataca tggaggatag ttccagaacg cctgagtata caaaaaccca atgcatactc     1260

aagtcccaca gtgggcccta cagaacccac gtatgtgata aatcagccct ccatgtacgc     1320

aggtttcgcc ccctgccaat actgtatttt caacctgtat ggttgaaaaa aatccatata     1380

taagtgcagc catgcagttc aaacccatat tgttcaaggg tcaactgtat agtttattga     1440

acagccacac ccattccttt acacatgatc tatggcagag ttgaatagtt gcaacagaca     1500

ctatgtggcc tgcaaaatcg gaaattttta ctgtctggcc ttttacagaa aagtttgcca     1560

gcccctgatc tagaccagca gctcatctga tagaggcaga ggtggcctta aagatgtggc     1620

cttcttcatt ttctgttggt ttggtttcgt ttctatgaga gatttcctct gatagctctg     1680

ctttccccag cacttactct ctgagctttt aaatgttctc tctgggagct tcatataagc     1740

tcggtgacat ttgagccaca gtttttagat cagcacctgg aatacatgac acattcttac     1800

tgaggtcatc cagcactgcc atggtggctg cccagtcttc tggccagtgt gccaggcaca     1860

tgtccctgtc acacaggttc caagaaacac atacgcagcc atgcatagac caacagattt     1920

aatattatat tgcagttttc agcgatgcag aatgcagctg caattgtgtt ttaaggagaa     1980

gccaaatggg gatggttgtc cctgcaacat ggtgccactc ctgggccatg tgcagcctca     2040

gtggacactc ttccatagcg ctgaggccct ggccccgcct ccagttaccc tgtactgccc     2100

actgccttac agttcagtgc gcaggccttc accttttcat caccagcctc tctgctcagt     2160

gctctggagt tcttgacctt gtcctttatc atgagatttg ctgaaatcac taatgaaaat     2220

aactcccaaa agcaacaaac aaaaatatta gtttaactgg cactgtggta tattaaaagg     2280

cacaagggca ttgtggctta acacttttgc tggatcccaa gagacgcaca tgatgttaaa     2340

aagagatctg gcagcagtac taatactaca tttcagtgta atcatcttgg ggtggtttgg     2400

ccaggatttc ccaattcctt gatatctgga gtttcttcac cattgtccgg catcctgcgg     2460

aggcttaata tacaggcgta aggtcagcag caatttgtct aataagtgat gagatcagta     2520

gctgaagtct ctaagctggg ccattactaa ataccatagc catgttgatc tggaaattta     2580

tccctctagt gtcttacctc acataagcca tttgcccact gtgcaatata gaaaggtgtt     2640

ttcaaaagta tttggccgta gattttcaca tccatcataa ggttggcatt caataaggaa     2700

aaagttctaa ctccagtatt aaattgtaca taaatcccaa atgttcttaa agaacactca     2760

gggacatgtt tgttgcctgg gattggtaat gaaaggttgg tttttgaaac ttgaaatttc     2820

accattggtt tttttcctat catttctgca tatccagcaa aaggaatctc atgttgactc     2880

ctggcagagt tcagtggctt cagtctgtct atctgttctg aggggaaaat tgtgttctgg     2940

atccagtaat caatttggca actttaatcg aggttttcaa aattccaagg agggttaata     3000

aagaatgata atcagtttta tttgctaata gctaagacaa atttgtaata aagtgtttta     3060

taatacttca aaagcaaaaa aaaaaaaaaa aa                                   3092


<210>  677
<211>  516
<212>  PRT
<213>  Homo sapiens

<400>  677

Met Pro Ser Ser Thr Ser Pro Asp Gln Gly Asp Asp Leu Glu Asn Cys 
1               5                   10                  15      


Ile Leu Arg Phe Ser Asp Leu Asp Leu Lys Asp Met Ser Leu Ile Asn 
            20                  25                  30          


Pro Ser Ser Ser Leu Lys Ala Glu Leu Asp Gly Ser Thr Lys Lys Lys 
        35                  40                  45              


Tyr Ser Phe Ala Lys Lys Lys Ala Phe Ala Leu Phe Val Lys Thr Lys 
    50                  55                  60                  


Glu Val Pro Thr Lys Arg Ser Phe Glu Cys Lys Glu Lys Leu Trp Lys 
65                  70                  75                  80  


Cys Cys Arg Gln Leu Phe Thr Asp Gln Thr Ser Ile His Arg His Val 
                85                  90                  95      


Ala Thr Gln His Ala Asp Glu Ile Tyr His Gln Thr Ala Ser Ile Leu 
            100                 105                 110         


Lys Gln Leu Ala Val Thr Leu Ser Thr Ser Lys Ser Leu Ser Ser Ala 
        115                 120                 125             


Asp Glu Lys Asn Pro Leu Lys Glu Cys Leu Pro His Ser His Asp Val 
    130                 135                 140                 


Ser Ala Trp Leu Pro Asp Ile Ser Cys Phe Asn Pro Asp Glu Leu Ile 
145                 150                 155                 160 


Ser Gly Gln Gly Ser Glu Glu Gly Glu Val Leu Leu Tyr Tyr Cys Tyr 
                165                 170                 175     


His Asp Leu Glu Asp Pro Gln Trp Ile Cys Ala Trp Gln Thr Ala Leu 
            180                 185                 190         


Cys Gln His Leu His Leu Thr Gly Lys Ile Arg Ile Ala Ala Glu Gly 
        195                 200                 205             


Ile Asn Gly Thr Val Gly Gly Ser Lys Leu Ala Thr Arg Leu Tyr Val 
    210                 215                 220                 


Glu Val Met Leu Ser Phe Pro Leu Phe Lys Asp Asp Leu Cys Lys Asp 
225                 230                 235                 240 


Asp Phe Lys Thr Ser Lys Gly Gly Ala His Cys Phe Pro Glu Leu Arg 
                245                 250                 255     


Val Gly Val Phe Glu Glu Ile Val Pro Met Gly Ile Ser Pro Lys Lys 
            260                 265                 270         


Ile Ser Tyr Lys Lys Pro Gly Ile His Leu Ser Pro Gly Glu Phe His 
        275                 280                 285             


Lys Glu Val Glu Lys Phe Leu Ser Gln Ala Asn Gln Glu Gln Ser Asp 
    290                 295                 300                 


Thr Ile Leu Leu Asp Cys Arg Asn Phe Tyr Glu Ser Lys Ile Gly Arg 
305                 310                 315                 320 


Phe Gln Gly Cys Leu Ala Pro Asp Ile Arg Lys Phe Ser Tyr Phe Pro 
                325                 330                 335     


Ser Tyr Val Asp Lys Asn Leu Glu Leu Phe Arg Glu Lys Arg Val Leu 
            340                 345                 350         


Met Tyr Cys Thr Gly Gly Ile Arg Cys Glu Arg Gly Ser Ala Tyr Leu 
        355                 360                 365             


Lys Ala Lys Gly Val Cys Lys Glu Val Phe Gln Leu Lys Gly Gly Ile 
    370                 375                 380                 


His Lys Tyr Leu Glu Glu Phe Pro Asp Gly Phe Tyr Lys Gly Lys Leu 
385                 390                 395                 400 


Phe Val Phe Asp Glu Arg Tyr Ala Leu Ser Tyr Asn Ser Asp Val Val 
                405                 410                 415     


Ser Glu Cys Ser Tyr Cys Gly Ala Arg Trp Asp Gln Tyr Lys Leu Cys 
            420                 425                 430         


Ser Thr Pro Gln Cys Arg Gln Leu Val Leu Thr Cys Pro Ala Cys Gln 
        435                 440                 445             


Gly Gln Gly Phe Thr Ala Cys Cys Val Thr Cys Gln Asp Lys Gly Ser 
    450                 455                 460                 


Arg Lys Val Ser Gly Pro Met Gln Asp Ser Phe Lys Glu Glu Cys Glu 
465                 470                 475                 480 


Cys Thr Ala Arg Arg Pro Arg Ile Pro Arg Glu Leu Leu Gln His Val 
                485                 490                 495     


Arg Gln Pro Val Ser Pro Glu Pro Gly Pro Asp Ala Asp Glu Asp Gly 
            500                 505                 510         


Pro Val Leu Met 
        515     


<210>  678
<211>  106
<212>  PRT
<213>  Homo sapiens

<400>  678

Met Ala Phe Pro Ser Ser Pro Glu Cys Ser Tyr Cys Gly Ala Arg Trp 
1               5                   10                  15      


Asp Gln Tyr Lys Leu Cys Ser Thr Pro Gln Cys Arg Gln Leu Val Leu 
            20                  25                  30          


Thr Cys Pro Ala Cys Gln Gly Gln Gly Phe Thr Ala Cys Cys Val Thr 
        35                  40                  45              


Cys Gln Asp Lys Gly Ser Arg Lys Val Ser Gly Pro Met Gln Asp Ser 
    50                  55                  60                  


Phe Lys Glu Glu Cys Glu Cys Thr Ala Arg Arg Pro Arg Ile Pro Arg 
65                  70                  75                  80  


Glu Leu Leu Gln His Val Arg Gln Pro Val Ser Pro Glu Pro Gly Pro 
                85                  90                  95      


Asp Ala Asp Glu Asp Gly Pro Val Leu Met 
            100                 105     


<210>  679
<211>  3697
<212>  DNA
<213>  Homo sapiens

<400>  679
agcggaagga ggcagccgaa ggccgagctg ggtggctgga ccgggtgctg gctgcgccgc       60

gctgctttcg gctcccacgg cctctcccat gcgctgaggg agcccggctg ggccgggccg      120

gcggcgggag gggaggctcc tctccatggt ccagaagacc agcatgtccc ggggccctta      180

cccaccctcc caggagatcc ccatggaggt cttcgacccc agcccgcagg gcaaatacag      240

caagaggaaa gggcgattca aacggtcaga tgggagcacg tcctcggata ccacatccaa      300

cagctttgtc cgccagggct cagcggagtc ctacaccagc cgtccatcag actctgatgt      360

atctctggag gaggaccggg aagccttaag gaaggaagca gagcgccagg cattagcgca      420

gctcgagaag gccaagacca agccagtggc atttgctgtg cggacaaatg ttggctacaa      480

tccgtctcca ggggatgagg tgcctgtgca gggagtggcc atcaccttcg agcccaaaga      540

cttcctgcac atcaaggaga aatacaataa tgactggtgg atcgggcggc tggtgaagga      600

gggctgtgag gttggcttca ttcccagccc cgtcaaactg gacagccttc gcctgctgca      660

ggaacagaag ctgcgccaga accgcctcgg ctccagcaaa tcaggcgata actccagttc      720

cagtctggga gatgtggtga ctggcacccg ccgccccaca ccccctgcca gtgccaaaca      780

gaagcagaag tcgacagagc atgtgccccc ctatgacgtg gtgccttcca tgaggcccat      840

catcctggtg ggaccgtcgc tcaagggcta cgaggttaca gacatgatgc agaaagcttt      900

atttgacttc ttgaagcatc ggtttgatgg caggacctcc atcactcgtg tgacggcaga      960

tatttccctg gctaagcgct cagttctcaa caaccccagc aaacacatca tcattgagcg     1020

ctccaacaca cgctccagcc tggctgaggt gcagagtgaa atcgagcgaa tcttcgagct     1080

ggcccggacc cttcagttgg tcgctctgga tgctgacacc atcaatcacc cagcccagct     1140

gtccaagacc tcgctggccc ccatcattgt ttacatcaag atcacctctc ccaaggtact     1200

tcaaaggctc atcaagtccc gaggaaagtc tcagtccaaa cacctcaatg tccaaatagc     1260

ggcctcggaa aagctggcac agtgccaccc tgaaatgttt gacatcatcc tggatgagaa     1320

ccaattggag gatgcctgcg agcatctggc ggagtacttg gaagcctatt ggaaggccac     1380

acacccgccc agcagcacgc cacccaatcc gctgctgaac cgcaccatgg ctaccgcagc     1440

cctggctgcc agccctgccc ctgtctccaa cctccaggga ccctaccttg cttccgggga     1500

ccagccactg gaacgggcca ccggggagca cgccagcatg cacgagtacc caggggagct     1560

gggccagccc ccaggccttt accccagcag ccacccacca ggccgggcag gcacgctacg     1620

ggcactgtcc cgccaagaca cttttgatgc cgacaccccc ggcagccgaa actctgccta     1680

cacggagctg ggagactcat gtgtggacat ggagactgac ccctcagagg ggccagggct     1740

tggagaccct gcagggggcg gcacgccccc agcccgacag ggatcctggg aggacgagga     1800

agaagactat gaggaagagc tgaccgacaa ccggaaccgg ggccggaata aggcccgcta     1860

ctgcgctgag ggtgggggtc cagttttggg gcgcaacaag aatgagctgg agggctgggg     1920

acgaggcgtc tacattcgct gagaggcagg ggccacacgg cgggaggaag ggctctgagc     1980

ccaggggagg ggagggagcg aggggctcac acctgacatg tattcgcctc cagggggcgc     2040

tgtctccctc ctttcagatg cctttgctca aagcttgggg tttctttggt gttaccatcc     2100

cagctcccgg gaggccctta agccccagct gtcggttttt acctgcctgt tgtggatgga     2160

tgggggatac ccacctttct gaagtgtccc ctttctccca tcttaagggg ctctcctccc     2220

tcaccctcct agagaaaagg tgcacttcct taactctttc tactcggggc cctaagtgac     2280

ggtcctaagt gggatggctc tccttctccc aagctgcagt actggggaag ggctgggcgc     2340

ttttcctgga aagggaggcc acagattctt tcccatgggg gctctcttcc ccagacccca     2400

gatccaaggt ccctcaccct gcctgcccct tcctcccagc ttcctggcag catcgtctgg     2460

tcggtgaaag ccatagcatg gacaccccat ggggagcttg ccttggggag ggttctgggt     2520

ggaagctggc aggcatacag caccctctac cctccgtggc catggcaacg tccagggccc     2580

agaaccctga ggagtgagcg gccgagacgc tgctccccac cccccacctc catgcctcag     2640

cctttgccta ccccaggaat gagcttggcc tccaacatcc cttgcctgct gccattagta     2700

gagggggccc ctctgcatct gagcccccca tccctgtgcc acctgggtgt ggagcccatg     2760

gaacactctg gtccgcctca ttttaaacca aaaaactgct ccttcaccct caccctgagg     2820

ccccagggga gaggacccgt gggatggtgc ccaggggttg ccttgggacc tcggatctcc     2880

tctggggggc ttggctgctg ctgttgctgc tctgtatttg cctctcgtga ttctgtttgt     2940

tacccatgtt cacttccccc aggagaggcc ttggtacccc ctctcccctg gggcatccct     3000

ttgccttggc atccctgtag cccagcaacc ctgcccctcc ccagcatccc agctgggcca     3060

gagagagccg agtgtgccaa caaggactgg ggcctgcccg gctgcccgcc tcagggatgg     3120

gcacctcatg cctgtctcgc cacctcctgt gccaatgtcc caccctccac ctgggggtgg     3180

ggtgcagctt ccacttactg attagaagac accactgccc tcccttcccc cctccctgtc     3240

tggtgtcctg tgcccccatc tgtctgtcta tatttgtctg tactccccta ggagaagtat     3300

tttgccatat ataaaaccac tgtcctgtcc tttgtggctg cctcccaagc ctgcttcttt     3360

gtcctcgcca catagtcgtc agcgtaggca cctgggagct gctgatatgc acggggagtt     3420

gaaagggtgg gtgcctgaag atgttgtgcc ctgagtcatt gactcaaaag aaaagatgat     3480

cctttgattt tggccctctg atgtattgtg cccaagccag gagctgcttg ggcagtccca     3540

gctccacact ggccctgagc cccttcactt acctgtctct ccacaagtag agccaaaggc     3600

aatgggaagc tcaatgttgc tcagtgggtg agatccagac ccactggtgc aatgtcttaa     3660

atacacatga ctgtttttcc gaaaaaaaaa aaaaaaa                              3697


<210>  680
<211>  598
<212>  PRT
<213>  Homo sapiens

<400>  680

Met Val Gln Lys Thr Ser Met Ser Arg Gly Pro Tyr Pro Pro Ser Gln 
1               5                   10                  15      


Glu Ile Pro Met Glu Val Phe Asp Pro Ser Pro Gln Gly Lys Tyr Ser 
            20                  25                  30          


Lys Arg Lys Gly Arg Phe Lys Arg Ser Asp Gly Ser Thr Ser Ser Asp 
        35                  40                  45              


Thr Thr Ser Asn Ser Phe Val Arg Gln Gly Ser Ala Glu Ser Tyr Thr 
    50                  55                  60                  


Ser Arg Pro Ser Asp Ser Asp Val Ser Leu Glu Glu Asp Arg Glu Ala 
65                  70                  75                  80  


Leu Arg Lys Glu Ala Glu Arg Gln Ala Leu Ala Gln Leu Glu Lys Ala 
                85                  90                  95      


Lys Thr Lys Pro Val Ala Phe Ala Val Arg Thr Asn Val Gly Tyr Asn 
            100                 105                 110         


Pro Ser Pro Gly Asp Glu Val Pro Val Gln Gly Val Ala Ile Thr Phe 
        115                 120                 125             


Glu Pro Lys Asp Phe Leu His Ile Lys Glu Lys Tyr Asn Asn Asp Trp 
    130                 135                 140                 


Trp Ile Gly Arg Leu Val Lys Glu Gly Cys Glu Val Gly Phe Ile Pro 
145                 150                 155                 160 


Ser Pro Val Lys Leu Asp Ser Leu Arg Leu Leu Gln Glu Gln Lys Leu 
                165                 170                 175     


Arg Gln Asn Arg Leu Gly Ser Ser Lys Ser Gly Asp Asn Ser Ser Ser 
            180                 185                 190         


Ser Leu Gly Asp Val Val Thr Gly Thr Arg Arg Pro Thr Pro Pro Ala 
        195                 200                 205             


Ser Ala Lys Gln Lys Gln Lys Ser Thr Glu His Val Pro Pro Tyr Asp 
    210                 215                 220                 


Val Val Pro Ser Met Arg Pro Ile Ile Leu Val Gly Pro Ser Leu Lys 
225                 230                 235                 240 


Gly Tyr Glu Val Thr Asp Met Met Gln Lys Ala Leu Phe Asp Phe Leu 
                245                 250                 255     


Lys His Arg Phe Asp Gly Arg Ile Ser Ile Thr Arg Val Thr Ala Asp 
            260                 265                 270         


Ile Ser Leu Ala Lys Arg Ser Val Leu Asn Asn Pro Ser Lys His Ile 
        275                 280                 285             


Ile Ile Glu Arg Ser Asn Thr Arg Ser Ser Leu Ala Glu Val Gln Ser 
    290                 295                 300                 


Glu Ile Glu Arg Ile Phe Glu Leu Ala Arg Thr Leu Gln Leu Val Ala 
305                 310                 315                 320 


Leu Asp Ala Asp Thr Ile Asn His Pro Ala Gln Leu Ser Lys Thr Ser 
                325                 330                 335     


Leu Ala Pro Ile Ile Val Tyr Ile Lys Ile Thr Ser Pro Lys Val Leu 
            340                 345                 350         


Gln Arg Leu Ile Lys Ser Arg Gly Lys Ser Gln Ser Lys His Leu Asn 
        355                 360                 365             


Val Gln Ile Ala Ala Ser Glu Lys Leu Ala Gln Cys Pro Pro Glu Met 
    370                 375                 380                 


Phe Asp Ile Ile Leu Asp Glu Asn Gln Leu Glu Asp Ala Cys Glu His 
385                 390                 395                 400 


Leu Ala Glu Tyr Leu Glu Ala Tyr Trp Lys Ala Thr His Pro Pro Ser 
                405                 410                 415     


Ser Thr Pro Pro Asn Pro Leu Leu Asn Arg Thr Met Ala Thr Ala Ala 
            420                 425                 430         


Leu Ala Ala Ser Pro Ala Pro Val Ser Asn Leu Gln Gly Pro Tyr Leu 
        435                 440                 445             


Ala Ser Gly Asp Gln Pro Leu Glu Arg Ala Thr Gly Glu His Ala Ser 
    450                 455                 460                 


Met His Glu Tyr Pro Gly Glu Leu Gly Gln Pro Pro Gly Leu Tyr Pro 
465                 470                 475                 480 


Ser Ser His Pro Pro Gly Arg Ala Gly Thr Leu Arg Ala Leu Ser Arg 
                485                 490                 495     


Gln Asp Thr Phe Asp Ala Asp Thr Pro Gly Ser Arg Asn Ser Ala Tyr 
            500                 505                 510         


Thr Glu Leu Gly Asp Ser Cys Val Asp Met Glu Thr Asp Pro Ser Glu 
        515                 520                 525             


Gly Pro Gly Leu Gly Asp Pro Ala Gly Gly Gly Thr Pro Pro Ala Arg 
    530                 535                 540                 


Gln Gly Ser Trp Glu Asp Glu Glu Glu Asp Tyr Glu Glu Glu Leu Thr 
545                 550                 555                 560 


Asp Asn Arg Asn Arg Gly Arg Asn Lys Ala Arg Tyr Cys Ala Glu Gly 
                565                 570                 575     


Gly Gly Pro Val Leu Gly Arg Asn Lys Asn Glu Leu Glu Gly Trp Gly 
            580                 585                 590         


Arg Gly Val Tyr Ile Arg 
        595             


<210>  681
<211>  592
<212>  PRT
<213>  Homo sapiens

<400>  681

Met Ser Arg Gly Pro Tyr Pro Pro Ser Gln Glu Ile Pro Met Glu Val 
1               5                   10                  15      


Phe Asp Pro Ser Pro Gln Gly Lys Tyr Ser Lys Arg Lys Gly Arg Phe 
            20                  25                  30          


Lys Arg Ser Asp Gly Ser Thr Ser Ser Asp Thr Thr Ser Asn Ser Phe 
        35                  40                  45              


Val Arg Gln Gly Ser Ala Glu Ser Tyr Thr Ser Arg Pro Ser Asp Ser 
    50                  55                  60                  


Asp Val Ser Leu Glu Glu Asp Arg Glu Ala Leu Arg Lys Glu Ala Glu 
65                  70                  75                  80  


Arg Gln Ala Leu Ala Gln Leu Glu Lys Ala Lys Thr Lys Pro Val Ala 
                85                  90                  95      


Phe Ala Val Arg Thr Asn Val Gly Tyr Asn Pro Ser Pro Gly Asp Glu 
            100                 105                 110         


Val Pro Val Gln Gly Val Ala Ile Thr Phe Glu Pro Lys Asp Phe Leu 
        115                 120                 125             


His Ile Lys Glu Lys Tyr Asn Asn Asp Trp Trp Ile Gly Arg Leu Val 
    130                 135                 140                 


Lys Glu Gly Cys Glu Val Gly Phe Ile Pro Ser Pro Val Lys Leu Asp 
145                 150                 155                 160 


Ser Leu Arg Leu Leu Gln Glu Gln Lys Leu Arg Gln Asn Arg Leu Gly 
                165                 170                 175     


Ser Ser Lys Ser Gly Asp Asn Ser Ser Ser Ser Leu Gly Asp Val Val 
            180                 185                 190         


Thr Gly Thr Arg Arg Pro Thr Pro Pro Ala Ser Ala Lys Gln Lys Gln 
        195                 200                 205             


Lys Ser Thr Glu His Val Pro Pro Tyr Asp Val Val Pro Ser Met Arg 
    210                 215                 220                 


Pro Ile Ile Leu Val Gly Pro Ser Leu Lys Gly Tyr Glu Val Thr Asp 
225                 230                 235                 240 


Met Met Gln Lys Ala Leu Phe Asp Phe Leu Lys His Arg Phe Asp Gly 
                245                 250                 255     


Arg Thr Ser Ile Thr Arg Val Thr Ala Asp Ile Ser Leu Ala Lys Arg 
            260                 265                 270         


Ser Val Leu Asn Asn Pro Ser Lys His Ile Ile Ile Glu Arg Ser Asn 
        275                 280                 285             


Thr Arg Ser Ser Leu Ala Glu Val Gln Ser Glu Ile Glu Arg Ile Phe 
    290                 295                 300                 


Glu Leu Ala Arg Thr Leu Gln Leu Val Ala Leu Asp Ala Asp Thr Ile 
305                 310                 315                 320 


Asn His Pro Ala Gln Leu Ser Lys Thr Ser Leu Ala Pro Ile Ile Val 
                325                 330                 335     


Tyr Ile Lys Ile Thr Ser Pro Lys Val Leu Gln Arg Leu Ile Lys Ser 
            340                 345                 350         


Arg Gly Lys Ser Gln Ser Lys His Leu Asn Val Gln Ile Ala Ala Ser 
        355                 360                 365             


Glu Lys Leu Ala Gln Cys His Pro Glu Met Phe Asp Ile Ile Leu Asp 
    370                 375                 380                 


Glu Asn Gln Leu Glu Asp Ala Cys Glu His Leu Ala Glu Tyr Leu Glu 
385                 390                 395                 400 


Ala Tyr Trp Lys Ala Thr His Pro Pro Ser Ser Thr Pro Pro Asn Pro 
                405                 410                 415     


Leu Leu Asn Arg Thr Met Ala Thr Ala Ala Leu Ala Ala Ser Pro Ala 
            420                 425                 430         


Pro Val Ser Asn Leu Gln Gly Pro Tyr Leu Ala Ser Gly Asp Gln Pro 
        435                 440                 445             


Leu Glu Arg Ala Thr Gly Glu His Ala Ser Met His Glu Tyr Pro Gly 
    450                 455                 460                 


Glu Leu Gly Gln Pro Pro Gly Leu Tyr Pro Ser Ser His Pro Pro Gly 
465                 470                 475                 480 


Arg Ala Gly Thr Leu Arg Ala Leu Ser Arg Gln Asp Thr Phe Asp Ala 
                485                 490                 495     


Asp Thr Pro Gly Ser Arg Asn Ser Ala Tyr Thr Glu Leu Gly Asp Ser 
            500                 505                 510         


Cys Val Asp Met Glu Thr Asp Pro Ser Glu Gly Pro Gly Leu Gly Asp 
        515                 520                 525             


Pro Ala Gly Gly Gly Thr Pro Pro Ala Arg Gln Gly Ser Trp Glu Asp 
    530                 535                 540                 


Glu Glu Glu Asp Tyr Glu Glu Glu Leu Thr Asp Asn Arg Asn Arg Gly 
545                 550                 555                 560 


Arg Asn Lys Ala Arg Tyr Cys Ala Glu Gly Gly Gly Pro Val Leu Gly 
                565                 570                 575     


Arg Asn Lys Asn Glu Leu Glu Gly Trp Gly Arg Gly Val Tyr Ile Arg 
            580                 585                 590         


<210>  682
<211>  1517
<212>  DNA
<213>  Homo sapiens

<400>  682
attctttggg gaggcaacta ggatggtgtg gccgaccacg gatttgcatt gccgaggacg       60

ggaccccagg gcagcgaagc agaatggcca acatgcaggg actggtggaa agactggaac      120

gagctgtcag ccgcctggag tcgctgtctg cagagtccca caggccccct gggaactgcg      180

gggaagtcaa tggtgtcatt gcaggtgtgg caccctccgt ggaagccttt gacaagctga      240

tggacagtat ggtggccgag tttttaaaga acagtaggat ccttgctggg gacgtggaga      300

cccatgcaga aatggtgcac agtgctttcc aggcccagcg ggctttcctt ctgatggcct      360

ctcagtacca acaaccccac gagaatgacg tggccgcact tctgaaaccc atatcggaaa      420

agattcagga aatccaaact ttcagagaga gaaaccgggg gagtaacatg tttaatcatc      480

tttcggccgt cagcgaaagc atccctgccc ttggatggat agctgtgtct cccaaacctg      540

gtccttatgt caaggagatg aatgacgctg ccacctttta cactaacagg gtcttaaagg      600

actacaaaca cagtgatttg cgtcatgtgg attgggtgaa gtcatatttg aacatttgga      660

gtgaacttca agcatacatc aaggaacacc acaccacggg cctcacatgg agcaaaacag      720

gtcctgtagc atccacagta tcagcgtttt ctgtcctctc ctctgggcct ggccttcctc      780

caccccctcc tcctctgcct cctccagggc cacctccact tttcgagaat gaaggcaaaa      840

aagaggaatc ttctccttca cgctcagctt tatttgccca acttaaccag ggagaagcaa      900

ttacaaaagg gctccgccat gtcacagatg accagaagac atacaaaaat cccagcctgc      960

gggctcaagg agggcaaact caatctccca ccaaaagtca cactccaagt cccacatctc     1020

ctaaatctta tccttctcaa aaacatgccc cagtgttgga gttggaagga aagaaatgga     1080

gagtggagta ccaagaggac aggaatgacc ttgtgatttc agagactgag ctgaaacaag     1140

tggcttacat tttcaaatgc gaaaaatcaa ctattcagat aaaagggaaa gtaaactcca     1200

ttataattga caactgtaag aaactcggcc tggtgtttga caatgtggtg ggcattgtgg     1260

aagtgatcaa ctcccaggac attcaaatcc aggtaatggg gagagtgcca acaatttcca     1320

ttaataagac agaaggttgc cacatatacc tcagtgaaga tgcattagac tgtgagatcg     1380

tgagcgccaa gtcatctgaa atgaacatac ttatccctca ggatggtgat tatagagaat     1440

ttcccattcc tgaacagttc aagacagcat gggatggatc caagttaatc actgaacctg     1500

cagaaattat ggcctaa                                                    1517


<210>  683
<211>  477
<212>  PRT
<213>  Homo sapiens

<400>  683

Met Ala Asn Met Gln Gly Leu Val Glu Arg Leu Glu Arg Ala Val Ser 
1               5                   10                  15      


Arg Leu Glu Ser Leu Ser Ala Glu Ser His Arg Pro Pro Gly Asn Cys 
            20                  25                  30          


Gly Glu Val Asn Gly Val Ile Ala Gly Val Ala Pro Ser Val Glu Ala 
        35                  40                  45              


Phe Asp Lys Leu Met Asp Ser Met Val Ala Glu Phe Leu Lys Asn Ser 
    50                  55                  60                  


Arg Ile Leu Ala Gly Asp Val Glu Thr His Ala Glu Met Val His Ser 
65                  70                  75                  80  


Ala Phe Gln Ala Gln Arg Ala Phe Leu Leu Met Ala Ser Gln Tyr Gln 
                85                  90                  95      


Gln Pro His Glu Asn Asp Val Ala Ala Leu Leu Lys Pro Ile Ser Glu 
            100                 105                 110         


Lys Ile Gln Glu Ile Gln Thr Phe Arg Glu Arg Asn Arg Gly Ser Asn 
        115                 120                 125             


Met Phe Asn His Leu Ser Ala Val Ser Glu Ser Ile Pro Ala Leu Gly 
    130                 135                 140                 


Trp Ile Ala Val Ser Pro Lys Pro Gly Pro Tyr Val Lys Glu Met Asn 
145                 150                 155                 160 


Asp Ala Ala Thr Phe Tyr Thr Asn Arg Val Leu Lys Asp Tyr Lys His 
                165                 170                 175     


Ser Asp Leu Arg His Val Asp Trp Val Lys Ser Tyr Leu Asn Ile Trp 
            180                 185                 190         


Ser Glu Leu Gln Ala Tyr Ile Lys Glu His His Thr Thr Gly Leu Thr 
        195                 200                 205             


Trp Ser Lys Thr Gly Pro Val Ala Ser Thr Val Ser Ala Phe Ser Val 
    210                 215                 220                 


Leu Ser Ser Gly Pro Gly Leu Pro Pro Pro Pro Pro Pro Leu Pro Pro 
225                 230                 235                 240 


Pro Gly Pro Pro Pro Leu Phe Glu Asn Glu Gly Lys Lys Glu Glu Ser 
                245                 250                 255     


Ser Pro Ser Arg Ser Ala Leu Phe Ala Gln Leu Asn Gln Gly Glu Ala 
            260                 265                 270         


Ile Thr Lys Gly Leu Arg His Val Thr Asp Asp Gln Lys Thr Tyr Lys 
        275                 280                 285             


Asn Pro Ser Leu Arg Ala Gln Gly Gly Gln Thr Gln Ser Pro Thr Lys 
    290                 295                 300                 


Ser His Thr Pro Ser Pro Thr Ser Pro Lys Ser Tyr Pro Ser Gln Lys 
305                 310                 315                 320 


His Ala Pro Val Leu Glu Leu Glu Gly Lys Lys Trp Arg Val Glu Tyr 
                325                 330                 335     


Gln Glu Asp Arg Asn Asp Leu Val Ile Ser Glu Thr Glu Leu Lys Gln 
            340                 345                 350         


Val Ala Tyr Ile Phe Lys Cys Glu Lys Ser Thr Ile Gln Ile Lys Gly 
        355                 360                 365             


Lys Val Asn Ser Ile Ile Ile Asp Asn Cys Lys Lys Leu Gly Leu Val 
    370                 375                 380                 


Phe Asp Asn Val Val Gly Ile Val Glu Val Ile Asn Ser Gln Asp Ile 
385                 390                 395                 400 


Gln Ile Gln Val Met Gly Arg Val Pro Thr Ile Ser Ile Asn Lys Thr 
                405                 410                 415     


Glu Gly Cys His Ile Tyr Leu Ser Glu Asp Ala Leu Asp Cys Glu Ile 
            420                 425                 430         


Val Ser Ala Lys Ser Ser Glu Met Asn Ile Leu Ile Pro Gln Asp Gly 
        435                 440                 445             


Asp Tyr Arg Glu Phe Pro Ile Pro Glu Gln Phe Lys Thr Ala Trp Asp 
    450                 455                 460                 


Gly Ser Lys Leu Ile Thr Glu Pro Ala Glu Ile Met Ala 
465                 470                 475         


<210>  684
<211>  477
<212>  PRT
<213>  Homo sapiens

<400>  684

Met Ala Asn Met Gln Gly Leu Val Glu Arg Leu Glu Arg Ala Val Ser 
1               5                   10                  15      


Arg Leu Glu Ser Leu Ser Ala Glu Ser His Arg Pro Pro Gly Asn Cys 
            20                  25                  30          


Gly Glu Val Asn Gly Val Ile Ala Gly Val Ala Pro Ser Val Glu Ala 
        35                  40                  45              


Phe Asp Lys Leu Met Asp Ser Met Val Ala Glu Phe Leu Lys Asn Ser 
    50                  55                  60                  


Arg Ile Leu Ala Gly Asp Val Glu Thr His Ala Glu Met Val His Ser 
65                  70                  75                  80  


Ala Phe Gln Ala Gln Arg Ala Phe Leu Leu Met Ala Ser Gln Tyr Gln 
                85                  90                  95      


Gln Pro His Glu Asn Asp Val Ala Ala Leu Leu Lys Pro Ile Ser Glu 
            100                 105                 110         


Lys Ile Gln Glu Ile Gln Thr Phe Arg Glu Arg Asn Arg Gly Ser Asn 
        115                 120                 125             


Met Phe Asn His Leu Ser Ala Val Ser Glu Ser Ile Pro Ala Leu Gly 
    130                 135                 140                 


Trp Ile Ala Val Ser Pro Lys Pro Gly Pro Tyr Val Lys Glu Met Asn 
145                 150                 155                 160 


Asp Ala Ala Thr Phe Tyr Thr Asn Arg Val Leu Lys Asp Tyr Lys His 
                165                 170                 175     


Ser Asp Leu Arg His Val Asp Trp Val Lys Ser Tyr Leu Asn Ile Trp 
            180                 185                 190         


Ser Glu Leu Gln Ala Tyr Ile Lys Glu His His Thr Thr Gly Leu Thr 
        195                 200                 205             


Trp Ser Lys Thr Gly Pro Val Ala Ser Thr Val Ser Ala Phe Ser Val 
    210                 215                 220                 


Leu Ser Ser Gly Pro Gly Leu Pro Pro Pro Pro Pro Pro Leu Pro Pro 
225                 230                 235                 240 


Pro Gly Pro Pro Pro Leu Phe Glu Asn Glu Gly Lys Lys Glu Glu Ser 
                245                 250                 255     


Ser Pro Ser Arg Ser Ala Leu Phe Ala Gln Leu Asn Gln Gly Glu Ala 
            260                 265                 270         


Ile Thr Lys Gly Leu Arg His Val Thr Asp Asp Gln Lys Thr Tyr Lys 
        275                 280                 285             


Asn Pro Ser Leu Arg Ala Gln Gly Gly Gln Thr Gln Ser Pro Thr Lys 
    290                 295                 300                 


Ser His Thr Pro Ser Pro Thr Ser Pro Lys Ser Tyr Pro Ser Gln Lys 
305                 310                 315                 320 


His Ala Pro Val Leu Glu Leu Glu Gly Lys Lys Trp Arg Val Glu Tyr 
                325                 330                 335     


Gln Glu Asp Arg Asn Asp Leu Val Ile Ser Glu Thr Glu Leu Lys Gln 
            340                 345                 350         


Val Ala Tyr Ile Phe Lys Cys Glu Lys Ser Thr Ile Gln Ile Lys Gly 
        355                 360                 365             


Lys Val Asn Ser Ile Ile Ile Asp Asn Cys Lys Lys Leu Gly Leu Val 
    370                 375                 380                 


Phe Asp Asn Val Val Gly Ile Val Glu Val Ile Asn Ser Gln Asp Ile 
385                 390                 395                 400 


Gln Ile Gln Val Met Gly Arg Val Pro Thr Ile Ser Ile Asn Lys Thr 
                405                 410                 415     


Glu Gly Cys His Ile Tyr Leu Ser Glu Asp Ala Leu Asp Cys Glu Ile 
            420                 425                 430         


Val Ser Ala Lys Ser Ser Glu Met Asn Ile Leu Ile Pro Gln Asp Gly 
        435                 440                 445             


Asp Tyr Arg Glu Phe Pro Ile Pro Glu Gln Phe Lys Thr Ala Trp Asp 
    450                 455                 460                 


Gly Ser Lys Leu Ile Thr Glu Pro Ala Glu Ile Met Ala 
465                 470                 475         


<210>  685
<211>  1166
<212>  DNA
<213>  Homo sapiens

<400>  685
accccatctc cagaggcacc ttccactagc aacagtctcc ccaggcacaa cacagctaac       60

acaaggcccc gcaggcagga ctctgggaca gacgcaggcc agctgcccag agcccagacc      120

aagcatggac gccgtggatg ccaccatgga gaaactccgg gcacagtgcc tgtcccgcgg      180

ggcctcgggc atccagggcc tggccaggtt tttccgccaa ctagaccggg acgggagcag      240

atccctggac gctgatgagt tccggcaggg tctggccaaa ctcgggctgg tgctggacca      300

ggcggaggca gagggtgtgt gcaggaagtg ggaccgcaat ggcagcggga cgctggatct      360

ggaggagttc cttcgggcgc tgcggccccc catgtcccag gcccgggagg ctgtcatcgc      420

agctgcattt gccaagctgg accgcagtgg ggacggcgtc gtgacggtgg acgacctccg      480

cggggtgtac agtggccgtg cccaccccaa ggtcacactg gcggaattcc aggactacta      540

cagcggcgtg agtgcctcca tgaacacgga tgaggagttc gtggccatga tgaccagtgc      600

ctggcagctg tgagcagctc cggctcagcc ctgctgccct ggcctgtcac tccccacccc      660

tgccggagac ctcccttccc tgggcccctt ctctcctggg cagccacacc acagagcggg      720

gaggggcagg tgggggaatg gaggctgcag gactggctag accaggtccc tgccggtcca      780

ccaggcggag gtgggacaaa ggtcctaaca ggagtcactg gctcaggacc ccagggagaa      840

acgctctccc cacccacgcc atgctgacca gaggtcttgc agcccctgtg gatgcccccg      900

ccgaggtccc ccgatccccg cacccggact gctgctccct gcccctccct tgcgggtccc      960

ccaggaagcc aggtgacccc aggtgggagg ctgtgtgtgg aggccatcct ggaaggaagt     1020

ttagacctgc ccaggtgtgg agcgaggggc acaggggcat cctaacctca gaaactgaaa     1080

taaagccttt gaaaaaaaaa tctgtaaaac atcaaccccc aatcagaaga tggcaaatgg     1140

ggaataaaaa tagcaggtaa cacgtc                                          1166


<210>  686
<211>  322
<212>  PRT
<213>  Homo sapiens

<400>  686

Ser Gln Arg Gly Lys Gly Thr Cys Pro Gly Ser His Arg Asn His Ala 
1               5                   10                  15      


Ser Ser Leu Pro Ser His Gly Leu Val Ser Ile Gln Gly Ile Ser Ala 
            20                  25                  30          


Pro Ala Gly Gln Trp Pro Ala Pro Pro Pro Trp Ser Gln Glu Gly Met 
        35                  40                  45              


Gln Cys His Arg Asp Leu Ala Leu Ser Gln Ala Leu Trp Gly Trp Gln 
    50                  55                  60                  


Leu Ser Lys Gln Ser Gly Trp Ala His Pro Ser Leu Pro His Ser Pro 
65                  70                  75                  80  


Leu Pro Ser Thr Val His Ser Cys Ser Trp Ala Pro Pro His Leu Gln 
                85                  90                  95      


Arg His Leu Pro Leu Ala Thr Val Ser Pro Gly Thr Thr Gln Leu Thr 
            100                 105                 110         


Gln Gly Pro Ala Gly Arg Thr Leu Gly Gln Thr Gln Ala Ser Cys Pro 
        115                 120                 125             


Glu Pro Arg Pro Ser Met Asp Ala Val Asp Ala Thr Met Glu Lys Leu 
    130                 135                 140                 


Arg Ala Gln Cys Leu Ser Arg Gly Ala Ser Gly Ile Gln Gly Leu Ala 
145                 150                 155                 160 


Arg Phe Phe Arg Gln Leu Asp Arg Asp Gly Ser Arg Ser Leu Asp Ala 
                165                 170                 175     


Asp Glu Phe Arg Gln Gly Leu Ala Lys Leu Gly Leu Val Leu Asp Gln 
            180                 185                 190         


Ala Glu Ala Glu Gly Val Cys Arg Lys Trp Asp Arg Asn Gly Ser Gly 
        195                 200                 205             


Thr Leu Asp Leu Glu Glu Phe Leu Arg Ala Leu Arg Pro Pro Met Ser 
    210                 215                 220                 


Gln Ala Arg Glu Ala Val Ile Ala Ala Ala Phe Ala Lys Leu Asp Arg 
225                 230                 235                 240 


Ser Gly Asp Gly Val Val Thr Val Asp Asp Leu Arg Gly Val Tyr Ser 
                245                 250                 255     


Gly Arg Ala His Pro Lys Val Arg Ser Gly Glu Trp Thr Glu Asp Glu 
            260                 265                 270         


Val Leu Arg Arg Phe Leu Asp Asn Phe Asp Ser Ser Glu Lys Asp Gly 
        275                 280                 285             


Gln Val Thr Leu Ala Glu Phe Gln Asp Tyr Tyr Ser Gly Val Ser Ala 
    290                 295                 300                 


Ser Met Asn Thr Asp Glu Glu Phe Val Ala Met Met Thr Ser Ala Trp 
305                 310                 315                 320 


Gln Leu 
        


<210>  687
<211>  162
<212>  PRT
<213>  Homo sapiens

<400>  687

Met Asp Ala Val Asp Ala Thr Met Glu Lys Leu Arg Ala Gln Cys Leu 
1               5                   10                  15      


Ser Arg Gly Ala Ser Gly Ile Gln Gly Leu Ala Arg Phe Phe Arg Gln 
            20                  25                  30          


Leu Asp Arg Asp Gly Ser Arg Ser Leu Asp Ala Asp Glu Phe Arg Gln 
        35                  40                  45              


Gly Leu Ala Lys Leu Gly Leu Val Leu Asp Gln Ala Glu Ala Glu Gly 
    50                  55                  60                  


Val Cys Arg Lys Trp Asp Arg Asn Gly Ser Gly Thr Leu Asp Leu Glu 
65                  70                  75                  80  


Glu Phe Leu Arg Ala Leu Arg Pro Pro Met Ser Gln Ala Arg Glu Ala 
                85                  90                  95      


Val Ile Ala Ala Ala Phe Ala Lys Leu Asp Arg Ser Gly Asp Gly Val 
            100                 105                 110         


Val Thr Val Asp Asp Leu Arg Gly Val Tyr Ser Gly Arg Ala His Pro 
        115                 120                 125             


Lys Val Thr Leu Ala Glu Phe Gln Asp Tyr Tyr Ser Gly Val Ser Ala 
    130                 135                 140                 


Ser Met Asn Thr Asp Glu Glu Phe Val Ala Met Met Thr Ser Ala Trp 
145                 150                 155                 160 


Gln Leu 
        


<210>  688
<211>  756
<212>  DNA
<213>  Homo sapiens

<400>  688
cgcgacgcgg gcgcaatggc ggggacccgg ggcttgatgc tgcttgggcc tggcccagtg       60

gcgggtccta gggacgtggg tacctgcaga ggccggcaga tggagattca gaaacataag      120

gacaacaaga aacttcccca aggtatcatt atagtcttta gacttcagac acacaccaca      180

cctcaaatat atacacaact gaaaggaaaa ttaaggaagt ttttcaaaga accctattcc      240

gagtaagaag tgtgttgcat gaatttctaa gagccagaaa atgcatgaca caggagaaga      300

tgtaccctca tctgttcagt gagagatgtg caaatcaaca tcaacacaga actgctgaag      360

aaaaaaaata tgtctctgaa aagcaactta ttcactggag atgtgaggag ccatccgcac      420

atcacaattc tatagacatc aaacgcatga agcatttcgg atctgcttta agactgaggc      480

agactttcca tctggacaca gccgaccatc catgtgtcat tacaatgaat ccagcacttc      540

cctggaagct ggaagggtca aattcaactt caactctgcc acttcctgct taacttgctg      600

tttaaccttg ggcaagctgc catcccacac gaggccgaag gtgtcggttt ttaaaataca      660

gaaatttggt tccatgaggg attatcaata tactgctggt gggccaaatt ccatctgcta      720

cttgcctttg taaataaagt tttattgaaa cacaaa                                756


<210>  689
<211>  102
<212>  PRT
<213>  Homo sapiens

<400>  689

Met Thr Gln Glu Lys Met Tyr Pro His Leu Phe Ser Glu Arg Cys Ala 
1               5                   10                  15      


Asn Gln His Gln His Arg Thr Ala Glu Glu Lys Lys Tyr Val Ser Glu 
            20                  25                  30          


Lys Gln Leu Ile His Trp Arg Cys Glu Glu Pro Ser Ala His His Asn 
        35                  40                  45              


Ser Ile Asp Ile Lys Arg Met Lys His Phe Gly Ser Ala Leu Arg Leu 
    50                  55                  60                  


Arg Gln Thr Phe His Leu Asp Thr Ala Asp His Pro Cys Val Ile Thr 
65                  70                  75                  80  


Met Asn Pro Ala Leu Pro Trp Lys Leu Glu Gly Ser Asn Ser Thr Ser 
                85                  90                  95      


Thr Leu Pro Leu Pro Ala 
            100         


<210>  690
<211>  102
<212>  PRT
<213>  Homo sapiens

<400>  690

Met Thr Gln Glu Lys Met Tyr Pro His Leu Phe Ser Glu Arg Cys Ala 
1               5                   10                  15      


Asn Gln His Gln His Arg Thr Ala Glu Glu Lys Lys Tyr Val Ser Glu 
            20                  25                  30          


Lys Gln Leu Ile His Trp Arg Cys Glu Glu Pro Ser Ala His His Asn 
        35                  40                  45              


Ser Ile Asp Ile Lys Arg Met Lys His Phe Gly Ser Ala Leu Arg Leu 
    50                  55                  60                  


Arg Gln Thr Phe His Leu Asp Thr Ala Asp His Pro Cys Val Ile Thr 
65                  70                  75                  80  


Met Asn Pro Ala Leu Pro Trp Lys Leu Glu Gly Ser Asn Ser Thr Ser 
                85                  90                  95      


Thr Leu Pro Leu Pro Ala 
            100         


<210>  691
<211>  1047
<212>  DNA
<213>  Homo sapiens

<400>  691
ggggattaca ggcatgcgcc accacacccg gccaattttt ttatttttgg tagagacggg       60

gtttagccat gttggccagg ctggtcttga actcctgacc tcaggtgatc cacccgtctc      120

agcctcccaa agtgctggga ttataggcgt gagccaccgc acctggcctt gttcctctga      180

ctttgatgca gctctaggtg ctggattgga gctaactctc cttccccgcc tggtcgtggg      240

aacctctctg tcccctccgg agccaaggcc tgctgggcca cgaggccgtg ttgagacatg      300

tccttcctcc tccccagggc ttggtggcca tccctgtctc catcttctat agtgtgccac      360

atcagaagca ctttgaccac tatatccgct tctgttttgt gaaggtaaag ggcagggctg      420

ggggaggaaa gacctcacag agcttcccaa ggccggctgg gcacatgggg agagtgtagg      480

actaatctgt gctggcgcag gatgaagcca cgctccaggc catggacgag aagctgcgga      540

agtggaaggt ggaactctag ccctgaagtc acgccttggc cctgacatcc ccatgcccgc      600

agagatcctc tttgagtgtc tgtctttgtc caggtttcag acatttctag gttggggaag      660

atgctattgg gaaacctctt ctccgtgaca cagaatgttc tgggtgggag ccgcccttct      720

tcatcttaga gaaccaagtg cctcctgtct gaaaggtgag ggtggcctga cctgggcctc      780

tccctgcccc tccataggtg ggtttgtagg gtcttgtgtt gcttctggtc tctccaggct      840

tggctgagac ggacggtaga cttccaccat gtaccgatca catcccagct ctgcatggcc      900

cctgctaagg ctcaggtata acctcacctt ccctggctca tcttggcctt ggggagttgc      960

ctttaggctt gagtcctcaa gcctctcctt ttcgtccata ataaaatgtt taaattatta     1020

agatcaaaaa aaaaaaaaaa aaaaaaa                                         1047


<210>  692
<211>  112
<212>  PRT
<213>  Homo sapiens

<400>  692

Met Arg His His Thr Arg Pro Ile Phe Leu Phe Leu Val Glu Thr Gly 
1               5                   10                  15      


Phe Ser His Val Gly Gln Ala Gly Leu Glu Leu Leu Thr Ser Gly Asp 
            20                  25                  30          


Pro Pro Val Ser Ala Ser Gln Ser Ala Gly Ile Ile Gly Val Ser His 
        35                  40                  45              


Arg Thr Trp Pro Cys Ser Ser Asp Phe Asp Ala Ala Leu Gly Ala Gly 
    50                  55                  60                  


Leu Glu Leu Thr Leu Leu Pro Arg Leu Val Val Gly Thr Ser Leu Ser 
65                  70                  75                  80  


Pro Pro Glu Pro Arg Pro Ala Gly Pro Arg Gly Arg Val Glu Thr Cys 
                85                  90                  95      


Pro Ser Ser Ser Pro Gly Leu Gly Gly His Pro Cys Leu His Leu Leu 
            100                 105                 110         


<210>  693
<211>  112
<212>  PRT
<213>  Homo sapiens

<400>  693

Met Arg His His Thr Arg Pro Ile Phe Leu Phe Leu Val Glu Thr Gly 
1               5                   10                  15      


Phe Ser His Val Gly Gln Ala Gly Leu Glu Leu Leu Thr Ser Gly Asp 
            20                  25                  30          


Pro Pro Val Ser Ala Ser Gln Ser Ala Gly Ile Ile Gly Val Ser His 
        35                  40                  45              


Arg Thr Trp Pro Cys Ser Ser Asp Phe Asp Ala Ala Leu Gly Ala Gly 
    50                  55                  60                  


Leu Glu Leu Thr Leu Leu Pro Arg Leu Val Val Gly Thr Ser Leu Ser 
65                  70                  75                  80  


Pro Pro Glu Pro Arg Pro Ala Gly Pro Arg Gly Arg Val Glu Thr Cys 
                85                  90                  95      


Pro Ser Ser Ser Pro Gly Leu Gly Gly His Pro Cys Leu His Leu Leu 
            100                 105                 110         


<210>  694
<211>  2400
<212>  DNA
<213>  Homo sapiens

<400>  694
caccattgtt ccatctgcga ggagcaccct ttctgcagaa agtaaaaatt gccttgctga       60

ggaaattaaa tatagcttaa ggattctgag ttgaagagca cagagctgca ggagaaagtg      120

actgagctgg agagtttgct ggaggagacc caggcaatct gcagagagaa ggagattcaa      180

ctggaaagcc tgaggcagag agaaacagaa ttctcctccg ctggacatag cctgcaagat      240

aaacagtctg tggaggagac cagtggagaa ggtccagaag tggaaatgga gtcctggcag      300

aagcgatacg attcgctcca aaagattgtg gagaagcagc agcagaagat ggatcagttg      360

cgctcacaag tacagagcct agagcaggaa gtggctcaag aagaaggaac aagccaggcc      420

ctgagagagg aggcccagcg aagggattca gccctgcagc agctgcgcac agccgtgaag      480

gagctttcag tgcaaaacca ggacttgatt gagaagaatc tgacactcca ggaacacctg      540

cgccaggccc aaccagggtc tccaccttca ccagacacgg cccagctggc acttgagctg      600

caccaggagt tggccagttg ccttcaagat ctgcaggctg tctgtagcat tgtgacccag      660

agggcccagg gccatgaccc caatctctcc ctgctcctgg gcattcactc agcacagcac      720

ccagagactc agctagattt gcagaagcca gatgtgatca agaggaaact agaagaggtt      780

caacagctgc gtcgtgacat tgaggactta aggaccacca tgtcagacag atatgcccag      840

gacatgggag aaaactgtgt cacacagtga ggaattctgg gggattcccc cagggaggag      900

ctgggctgct gagagcctag tccagcaggt ttctgccctg acattctctt gtctgctatt      960

cccagagaga agtctcagag gggaggggag agcctgcatc tgggggccaa gggctgatta     1020

gggaactgtg tcctacccac actggcatgt tggattacgt ttgtcctgtt aattcactct     1080

cgacggtgag ttactaatta acttttggca ggtacaacag ataagtcctc acaaactgtt     1140

cccagcccta ggctgacagg agagacgaac aggctgtcca cctttcttct ccatccaatg     1200

ggatggatcc atgttcattc ccacttcaca ccttggtcct gctgattaga gagctcatca     1260

gaggggcctg gaaaggctga gcaagtacca gtgacaatgg ccatttaaga attctcaggc     1320

cccatgtgcc agccttcttg ggaactgagc tggctttctg ggttttctca tgcctggtct     1380

tactgcttct tcctcagggc tcttgttctc ccagaagcct cagggtaatg tgttggttag     1440

cacgtaacta ctaggattgg ggccctaggg attatagcca ggactctaat ctgcctacca     1500

tgccatttaa caagagatcc cactctccag ctgccttgtg tccctagggt cctggccatg     1560

tgtttagtgt gctaaacttt ctcctttgtt ctcaggcctt ccaggtagtc cccttcctgg     1620

acttaagagt gcaaactctt ctctgtggtt ctagccttgg gcagaattat atcccagaga     1680

ccacagagca actgtcaagc tgcttacccc ctcacccagg gctacagcct gtgcccagcc     1740

ctctaatttg tgcctctctt gtgttggggg tggtgggggt tattcctttc cctttcctgc     1800

tctggcctcc ttgaaagttc agagtaccca gtacaagtca gctttaaagt acagctttta     1860

gtgtttcctg ggttgtttct ctggggcttt agtgagggac ctttgccctc tggtttttct     1920

tgcctcctgg tttagggagc atctcacact tgttagtatc tggttgttgg gccagccgtg     1980

cctcctctag atctggagcc aggccaggca ggggccacgt gtgggccagt cagccactac     2040

aagatttttg ctaagctttg ggctgttggc agcatcttgg acctcatgcc tgggcctgaa     2100

tgaggctctt tcttaagtgt ttttacaagt ttgtgtttta tttatggagt gacttacccc     2160

ttccattcag agcagcccca cccagccagc ccttcagcct ctgggctcct gctgcttaaa     2220

ggcagagccg cctggttggt ctccaccctg tgcattggga gcccagccac catgctgacg     2280

ggtatttttc ctcataaagt ttataaccag ttatttatat gaatctttgt tatgtccatt     2340

tgtttgtatt gcgtattttg attataaaat aaagtatctt aacagaaaaa aaaaaaaaaa     2400


<210>  695
<211>  762
<212>  PRT
<213>  Homo sapiens

<400>  695

Met Ala Met Gln Glu Lys Tyr Pro Thr Glu Gly Ile Ser His Val Thr 
1               5                   10                  15      


Ser Pro Ser Ser Asp Val Ile Gln Lys Gly Ser Ser Leu Gly Thr Glu 
            20                  25                  30          


Trp Gln Thr Pro Val Ile Ser Glu Pro Phe Arg Ser Arg Phe Ser Arg 
        35                  40                  45              


Cys Ser Ser Val Ala Asp Ser Gly Asp Thr Ala Ile Gly Thr Ser Cys 
    50                  55                  60                  


Ser Asp Ile Ala Glu Asp Phe Cys Ser Ser Ser Gly Ser Pro Pro Phe 
65                  70                  75                  80  


Gln Pro Ile Lys Ser His Val Thr Ile Pro Thr Ala His Val Met Pro 
                85                  90                  95      


Ser Thr Leu Gly Thr Ser Pro Ala Lys Pro Asn Ser Thr Pro Val Gly 
            100                 105                 110         


Pro Ser Ser Ser Lys Leu Pro Leu Ser Gly Leu Ala Glu Ser Val Gly 
        115                 120                 125             


Met Thr Arg Asn Gly Asp Leu Gly Ala Met Lys His Ser Pro Gly Leu 
    130                 135                 140                 


Ser Arg Asp Leu Met Tyr Phe Ser Gly Ala Thr Gly Glu Asn Gly Ile 
145                 150                 155                 160 


Glu Gln Ser Trp Phe Pro Ala Val Gly His Glu Arg Gln Glu Glu Ala 
                165                 170                 175     


Arg Lys Phe Asp Ile Pro Ser Met Glu Ser Thr Leu Asn Gln Ser Ala 
            180                 185                 190         


Met Met Glu Thr Leu Tyr Ser Asp Pro His His Arg Val Arg Phe His 
        195                 200                 205             


Asn Pro Arg Thr Ser Thr Ser Lys Glu Leu Tyr Arg Val Leu Pro Glu 
    210                 215                 220                 


Ala Lys Lys Ala Pro Gly Ser Gly Ala Val Phe Glu Arg Asn Gly Pro 
225                 230                 235                 240 


His Ser Asn Ser Ser Gly Val Leu Pro Leu Gly Leu Gln Pro Ala Pro 
                245                 250                 255     


Gly Leu Ser Lys Pro Leu Pro Ser Gln Val Trp Gln Pro Ser Pro Asp 
            260                 265                 270         


Thr Trp His Pro Arg Glu Gln Ser Cys Glu Leu Ser Thr Cys Arg Gln 
        275                 280                 285             


Gln Leu Glu Leu Ile Arg Leu Gln Met Glu Gln Met Gln Leu Gln Asn 
    290                 295                 300                 


Gly Ala Ile Cys His His Pro Ala Ala Phe Gly Pro Ser Leu Pro Ile 
305                 310                 315                 320 


Leu Glu Pro Ala Gln Trp Ile Ser Ile Leu Asn Ser Asn Glu His Leu 
                325                 330                 335     


Leu Lys Glu Lys Glu Leu Leu Ile Asp Lys Gln Arg Lys His Ile Ser 
            340                 345                 350         


Gln Leu Glu Gln Lys Val Arg Glu Ser Glu Leu Gln Val His Ser Ala 
        355                 360                 365             


Leu Leu Gly Arg Pro Ala Pro Phe Gly Asp Val Cys Leu Leu Arg Leu 
    370                 375                 380                 


Gln Glu Leu Gln Arg Glu Asn Thr Phe Leu Arg Ala Gln Phe Ala Gln 
385                 390                 395                 400 


Lys Thr Glu Ala Leu Ser Arg Glu Lys Ile Asp Leu Glu Lys Lys Leu 
                405                 410                 415     


Ser Ala Ser Glu Val Glu Val Gln Leu Ile Arg Glu Ser Leu Lys Val 
            420                 425                 430         


Ala Leu Gln Lys His Ser Glu Glu Val Lys Lys Gln Glu Glu Arg Val 
        435                 440                 445             


Lys Gly Arg Asp Lys His Ile Asn Asn Leu Lys Lys Lys Cys Gln Lys 
    450                 455                 460                 


Glu Ser Glu Gln Asn Arg Glu Lys Gln Gln Arg Ile Glu Thr Leu Glu 
465                 470                 475                 480 


Arg Tyr Leu Ala Asp Leu Pro Thr Leu Glu Asp His Gln Lys Gln Ser 
                485                 490                 495     


Gln Gln Leu Lys Asp Ser Glu Leu Lys Ser Thr Glu Leu Gln Glu Lys 
            500                 505                 510         


Val Thr Glu Leu Glu Ser Leu Leu Glu Glu Thr Gln Ala Ile Cys Arg 
        515                 520                 525             


Glu Lys Glu Ile Gln Leu Glu Ser Leu Arg Gln Arg Glu Ala Glu Phe 
    530                 535                 540                 


Ser Ser Ala Gly His Ser Leu Gln Asp Lys Gln Ser Val Glu Glu Thr 
545                 550                 555                 560 


Ser Gly Glu Gly Pro Glu Val Glu Met Glu Ser Trp Gln Lys Arg Tyr 
                565                 570                 575     


Asp Ser Leu Gln Lys Ile Val Glu Lys Gln Gln Gln Lys Met Asp Gln 
            580                 585                 590         


Leu Arg Ser Gln Val Gln Ser Leu Glu Gln Glu Val Ala Gln Glu Glu 
        595                 600                 605             


Gly Thr Ser Gln Ala Leu Arg Glu Glu Ala Gln Arg Arg Asp Ser Ala 
    610                 615                 620                 


Leu Gln Gln Leu Arg Thr Ala Val Lys Glu Leu Ser Val Gln Asn Gln 
625                 630                 635                 640 


Asp Leu Ile Glu Lys Asn Leu Thr Leu Gln Glu His Leu Arg Gln Ala 
                645                 650                 655     


Gln Pro Gly Ser Pro Pro Ser Pro Asp Thr Ala Gln Leu Ala Leu Glu 
            660                 665                 670         


Leu His Gln Glu Leu Ala Ser Cys Leu Gln Asp Leu Gln Ala Val Cys 
        675                 680                 685             


Ser Ile Val Thr Gln Arg Ala Gln Gly His Asp Pro Asn Leu Ser Leu 
    690                 695                 700                 


Leu Leu Gly Ile His Ser Ala Gln His Pro Glu Thr Gln Leu Asp Leu 
705                 710                 715                 720 


Gln Lys Pro Asp Val Ile Lys Arg Lys Leu Glu Glu Val Gln Gln Leu 
                725                 730                 735     


Arg Arg Asp Ile Glu Asp Leu Arg Thr Thr Met Ser Asp Arg Tyr Ala 
            740                 745                 750         


Gln Asp Met Gly Glu Asn Cys Val Thr Gln 
        755                 760         


<210>  696
<211>  194
<212>  PRT
<213>  Homo sapiens

<400>  696

Met Glu Ser Trp Gln Lys Arg Tyr Asp Ser Leu Gln Lys Ile Val Glu 
1               5                   10                  15      


Lys Gln Gln Gln Lys Met Asp Gln Leu Arg Ser Gln Val Gln Ser Leu 
            20                  25                  30          


Glu Gln Glu Val Ala Gln Glu Glu Gly Thr Ser Gln Ala Leu Arg Glu 
        35                  40                  45              


Glu Ala Gln Arg Arg Asp Ser Ala Leu Gln Gln Leu Arg Thr Ala Val 
    50                  55                  60                  


Lys Glu Leu Ser Val Gln Asn Gln Asp Leu Ile Glu Lys Asn Leu Thr 
65                  70                  75                  80  


Leu Gln Glu His Leu Arg Gln Ala Gln Pro Gly Ser Pro Pro Ser Pro 
                85                  90                  95      


Asp Thr Ala Gln Leu Ala Leu Glu Leu His Gln Glu Leu Ala Ser Cys 
            100                 105                 110         


Leu Gln Asp Leu Gln Ala Val Cys Ser Ile Val Thr Gln Arg Ala Gln 
        115                 120                 125             


Gly His Asp Pro Asn Leu Ser Leu Leu Leu Gly Ile His Ser Ala Gln 
    130                 135                 140                 


His Pro Glu Thr Gln Leu Asp Leu Gln Lys Pro Asp Val Ile Lys Arg 
145                 150                 155                 160 


Lys Leu Glu Glu Val Gln Gln Leu Arg Arg Asp Ile Glu Asp Leu Arg 
                165                 170                 175     


Thr Thr Met Ser Asp Arg Tyr Ala Gln Asp Met Gly Glu Asn Cys Val 
            180                 185                 190         


Thr Gln 
        


<210>  697
<211>  3416
<212>  DNA
<213>  Homo sapiens

<400>  697
cagtttcagg gtctcgccgg cagccccagc cggcgggcgc ggagcgggca gcggggcccg       60

gatcgcaggc tcctctgggg gccccggagt tgggaagcgg cgtccgggag cccccggagg      120

aggatgggct gcagacacag caggctgagc agctgcaaac ccccgaaaaa gaagcgccaa      180

gaaccagaac cagaacagcc acccagacca gagccccatg aattaggtcc cctcaatggg      240

gacacagcta taactgtcca gctctgtgca tcagaggagg ctgagcggca ccagaaggat      300

ataaccagaa ttctccagca acatgaggag gaaaagaaga aatgggcaca acaggtggag      360

aaggaaaggg agctagagct tcgagacaga ctggatgagc agcaaagggt cctggaagga      420

aagaatgaag aggccctgca agtcctccgg gcctcatatg aacaggagaa agaagcgctt      480

acccactctt tccgggaggc cagttctacc cagcaggaga ccatagacag actgacctca      540

cagctggagg ctttccaggc caaaatgaag agggtggagg agtccattct gagccgaaac      600

tataagaaac atatccagga ttatgggagc cccagccagt tctgggagca ggagctggag      660

agcttacact ttgtcatcga gatgaagaat gagcgtattc atgagctgga caggcggctg      720

atcctcatgg aaacagtgaa agagaaaaat ctgatattgg aggaaaaaat tacgaccctg      780

caacaggaaa atgaggacct ccatgtccga agccgcaacc aggtggtcct gtcaaggcag      840

ctgtcagaag acctgcttct cacgcgtgag gccctggaga aggaggtgca gctgcggcga      900

cagctccagc aggagaagga ggagctgttg taccgggtcc ttggggccaa tgcctcgcct      960

gccttccctc tggcccctgt cactcccact gaggtctctt tcctcgccac atagggtgca     1020

gggcctgggc ccaccacgac gcctgaagtc acagctcctt ccaaggtttt tctggagaag     1080

acagcaggag cctctcagtt cttttccagg aaggaacgag ggtgggagcg agatggagat     1140

cctgggtgtg tgcccagtga gccctggggc cttgagttac atggaatcac ccacagggtt     1200

ttggaggccc cgagaagcgt cttcccttga gttggccaag ggaataagca agaggagaca     1260

tttcctccct gccccagcac tctgtcccaa tccgagaagt tccgaggctt tcccaggggc     1320

agtctgtgtc acgctggcca tttgacataa aggagacagc ccctggtccc agcttgtcag     1380

ctctgctgcc gacttgctga cttatcaact tcctctaggt gtttccactc caccctggcc     1440

tgctcagagc ctcagtttac ccctgcatta aaatggtggg gggactggtc aaaggactct     1500

tatgtcactg cagtgtccca ttctaggatt gtctgaaggc cagagtaggg gttgggggga     1560

gtgtggacaa accccgcaaa tcagagtggg gaaggtgagt ggtagagagg gggtctctga     1620

aggcccttgg ggctgacagg gccaggcagc ctccccagct gaggcatcat tcctgggcca     1680

gagtcgtgtc caccaaggga cagtagccag agctcctctt cctttaccag gcaaggtgca     1740

tcccctcagc cctcctggcc cttcagtctt ggtgccacct gggcacaggg gcaagcttgg     1800

tggttgtgag tccattcatc tatcagagct ggaacctcat ccctgcacag atgaggaaac     1860

caaggcatgg agcagttccc agagtcgaat ctagatctca tctgtcatcc gggtcttatc     1920

ctttgctctg tttttctctt caggctctgg aaaatcagat ctgtgactta atcttcctct     1980

ccctggccct cacccactta gtttcttttt cattcctgct ccctgcctta actcctcctc     2040

ccactgcccc tgatcccagg cccaggcttt tacaacctgg tgctcagctt ccccatcagt     2100

gaaaaggggt ggctagagta actaacctca gcaggccgtc cagtcctgat agtctgtgga     2160

tttcggatcc ttctcaggaa gcttcatgtc taatggagac tataattata actcctgttc     2220

tgcatagagc atttgcatca aaggctttcc atacccctcc ctcccctggt cctcataaga     2280

tccttgaagc aggttcctat tcctcattgg caacatggca aacagatcac aggagtcaaa     2340

gggccttgct caaggtcccc agcttcagcc ccaggcccta agccagcgtc agaacagtca     2400

atctgcattt ttcatcagtc attctatagt gacatcatcc cagactgcct tctgtattcc     2460

cctgtgtaca gtctccttct gtttctaggt ttagaagttc agaggtgact gtgtttctcc     2520

atttccacag ccaaatgggg gaagaggtga ggctagggga gtgctgtgct gattctccag     2580

ccatggtcag acaggtcacc caggagcctc gaggaaagcc ctggagggaa tcacatgtgt     2640

actttttcat gaagcttttt gcaaagcaca tctgcgatac actagtttat tgaactaatg     2700

tccaggagta gacatgattg gtggccaagt tatttgggga cacctaaaca gatcagtgac     2760

ctgaatgact tctcagaacc tttaatatgc caatgtgtgt ggcaaactta caagaaggga     2820

gctaagtatc cagcctctcc caaacctctt tgaacaaagc ttctgtccct cccacacctc     2880

tcacctcaca ggcacatcag gctgcagaat gcgctttaga aagcattgtt ttagtccagg     2940

cacagtggct cacgcctgta atcccagcac tttgggaggc cgaggtgggt ggatcacaag     3000

gttgggagat tgagaccatc ctggctaaca cagtgaaacc ctgtctctac taaaaaaata     3060

caaaaaatta gcttggcgtg gtggtgggcg cctgtagtcc cagcagcttg ggaggctgag     3120

gctggagaat ggtgtgaacc caggaggcgg agcttgcagt gagccaagat cgcgccactg     3180

cactccagcc cgggtgacag agcaagactc cgtctcaaaa aaaagaaaag aaaaaagaaa     3240

gcattgtttt aattgagagg ggcagggctg gagaaggagc aagttgtggg gagccaggct     3300

tccctcacgc agcctgtggt ggatgtggga aggagatcaa cttctcctca ctctgggaca     3360

gacgatgtat ggaaactaaa aagaacatgc ggcaccttaa aaaaaaaaaa aaaaaa         3416


<210>  698
<211>  296
<212>  PRT
<213>  Homo sapiens

<400>  698

Met Gly Cys Arg His Ser Arg Leu Ser Ser Cys Lys Pro Pro Lys Lys 
1               5                   10                  15      


Lys Arg Gln Glu Pro Glu Pro Glu Gln Pro Pro Arg Pro Glu Pro His 
            20                  25                  30          


Glu Leu Gly Pro Leu Asn Gly Asp Thr Ala Ile Thr Val Gln Leu Cys 
        35                  40                  45              


Ala Ser Glu Glu Ala Glu Arg His Gln Lys Asp Ile Thr Arg Ile Leu 
    50                  55                  60                  


Gln Gln His Glu Glu Glu Lys Lys Lys Trp Ala Gln Gln Val Glu Lys 
65                  70                  75                  80  


Glu Arg Glu Leu Glu Leu Arg Asp Arg Leu Asp Glu Gln Gln Arg Val 
                85                  90                  95      


Leu Glu Gly Lys Asn Glu Glu Ala Leu Gln Val Leu Arg Ala Ser Tyr 
            100                 105                 110         


Glu Gln Glu Lys Glu Ala Leu Thr His Ser Phe Arg Glu Ala Ser Ser 
        115                 120                 125             


Thr Gln Gln Glu Thr Ile Asp Arg Leu Thr Ser Gln Leu Glu Ala Phe 
    130                 135                 140                 


Gln Ala Lys Met Lys Arg Val Glu Glu Ser Ile Leu Ser Arg Asn Tyr 
145                 150                 155                 160 


Lys Lys His Ile Gln Asp Tyr Gly Ser Pro Ser Gln Phe Trp Glu Gln 
                165                 170                 175     


Glu Leu Glu Ser Leu His Phe Val Ile Glu Met Lys Asn Glu Arg Ile 
            180                 185                 190         


His Glu Leu Asp Arg Arg Leu Ile Leu Met Glu Thr Val Lys Glu Lys 
        195                 200                 205             


Asn Leu Ile Leu Glu Glu Lys Ile Thr Thr Leu Gln Gln Glu Asn Glu 
    210                 215                 220                 


Asp Leu His Val Arg Ser Arg Asn Gln Val Val Leu Ser Arg Gln Leu 
225                 230                 235                 240 


Ser Glu Asp Leu Leu Leu Thr Arg Glu Ala Leu Glu Lys Glu Val Gln 
                245                 250                 255     


Leu Arg Arg Gln Leu Gln Gln Glu Lys Glu Glu Leu Leu Tyr Arg Val 
            260                 265                 270         


Leu Gly Ala Asn Ala Ser Pro Ala Phe Pro Leu Ala Pro Val Thr Pro 
        275                 280                 285             


Thr Glu Val Ser Phe Leu Ala Thr 
    290                 295     


<210>  699
<211>  296
<212>  PRT
<213>  Homo sapiens

<400>  699

Met Gly Cys Arg His Ser Arg Leu Ser Ser Cys Lys Pro Pro Lys Lys 
1               5                   10                  15      


Lys Arg Gln Glu Pro Glu Pro Glu Gln Pro Pro Arg Pro Glu Pro His 
            20                  25                  30          


Glu Leu Gly Pro Leu Asn Gly Asp Thr Ala Ile Thr Val Gln Leu Cys 
        35                  40                  45              


Ala Ser Glu Glu Ala Glu Arg His Gln Lys Asp Ile Thr Arg Ile Leu 
    50                  55                  60                  


Gln Gln His Glu Glu Glu Lys Lys Lys Trp Ala Gln Gln Val Glu Lys 
65                  70                  75                  80  


Glu Arg Glu Leu Glu Leu Arg Asp Arg Leu Asp Glu Gln Gln Arg Val 
                85                  90                  95      


Leu Glu Gly Lys Asn Glu Glu Ala Leu Gln Val Leu Arg Ala Ser Tyr 
            100                 105                 110         


Glu Gln Glu Lys Glu Ala Leu Thr His Ser Phe Arg Glu Ala Ser Ser 
        115                 120                 125             


Thr Gln Gln Glu Thr Ile Asp Arg Leu Thr Ser Gln Leu Glu Ala Phe 
    130                 135                 140                 


Gln Ala Lys Met Lys Arg Val Glu Glu Ser Ile Leu Ser Arg Asn Tyr 
145                 150                 155                 160 


Lys Lys His Ile Gln Asp Tyr Gly Ser Pro Ser Gln Phe Trp Glu Gln 
                165                 170                 175     


Glu Leu Glu Ser Leu His Phe Val Ile Glu Met Lys Asn Glu Arg Ile 
            180                 185                 190         


His Glu Leu Asp Arg Arg Leu Ile Leu Met Glu Thr Val Lys Glu Lys 
        195                 200                 205             


Asn Leu Ile Leu Glu Glu Lys Ile Thr Thr Leu Gln Gln Glu Asn Glu 
    210                 215                 220                 


Asp Leu His Val Arg Ser Arg Asn Gln Val Val Leu Ser Arg Gln Leu 
225                 230                 235                 240 


Ser Glu Asp Leu Leu Leu Thr Arg Glu Ala Leu Glu Lys Glu Val Gln 
                245                 250                 255     


Leu Arg Arg Gln Leu Gln Gln Glu Lys Glu Glu Leu Leu Tyr Arg Val 
            260                 265                 270         


Leu Gly Ala Asn Ala Ser Pro Ala Phe Pro Leu Ala Pro Val Thr Pro 
        275                 280                 285             


Thr Glu Val Ser Phe Leu Ala Thr 
    290                 295     


<210>  700
<211>  2561
<212>  DNA
<213>  Homo sapiens

<400>  700
gggggactcg agagctagct gagcgaatgg gccggcgact gtggagttag cgtcctcaat       60

gtggacgccc tgagctccca ttaggagccg ctggctgcgg cagcagggga ctagcgtgaa      120

agttggctaa aaaaaagaaa agaacatgga ggcagatata atcacaaatc ttcgatgcag      180

gctcaaagag gctgaagaag agcgactaaa agctgcacag tatggtttac aactagtaga      240

gagtcaaaat gaattacaga atcaattgga taaatgtcgt aatgaaatga tgaccatgac      300

tgagagttat gaacaagaaa aatataccct tcaaagagaa gttgaactca agagtcgaat      360

gttagaaagt ttgagctgcg aatgtgaagc tattaaacaa caacaaaaaa tgcacctgga      420

gaaattggaa gaacaactaa gcagaagcca tggacaggaa gtgaatgaac taaaaactaa      480

gatagaaaaa ctgaaagtgg aattagatga agccaggctt agtgaaaagc agctgaagca      540

ccaagtagat catcagaagg aactcctctc ttgtaaatca gaggaactgc gcgtaatgtc      600

tgaacgtgtg caggaaagca tgtcttcaga gatgctggct cttcaaattg agctgacaga      660

aatggagagt atgaagacca ccctcaaaga agaagtgaat gaactacaat acagacaaga      720

acagctagaa cttcttatta ctaacctaat gcgccaggta gaccggctta aagaggaaaa      780

agaggagcga gagaaagaag cagtttctta ctataatgcc ctagagaaag ctcgtgtagc      840

aaatcaagat cttcaggtac agttggacca ggcactccag caagccttgg atcccaatag      900

taaaggcaac tctttgtttg cagaggtgga agatcgaagg gcagcaatgg aacgtcagct      960

tatcagtatg aaagtcaagt atcagtcact aaagaagcaa aatgtattta acagagaaca     1020

gatgcagaga atgaagttac aaattgccac gttgctacag atgaaagggt ctcaaactga     1080

atttgagcag caggaacggt tgcttgccat gttggagcag aagaatggtg aaataaaaca     1140

tcttttaggt gaaattagaa atctggagaa atttaagaat ttatatgaca gtatggaatc     1200

taagccttca gtcgactctg gtactctgga agataacacc tattatacag atttacttca     1260

gatgaagctg gataacttaa acaaagaaat tgaaagcact aaaggtgaat tgtccataca     1320

gcgaatgaaa gcattatttg agagccagcg ggctctagat attgagcgaa aactttttgc     1380

aaatgaaaga tgcctccagc tttcagaaag tgaaaatatg aaactgagag ctaaactaga     1440

tgaattgaaa ctaaaatatg aacctgaaga gacagttgaa gtgcctgtac tgaaaaagag     1500

gcgtgaggtg ctccctgtgg atataaccac cgctaaagat gcatgtgtca acaacagtgc     1560

tctcggggga gaagtttatc gattaccgcc tcagaaagag gagacacagt cctgccctaa     1620

cagtttagaa gataacaact tgcaattaga aaaatcagtt tctatacaca caccagtagt     1680

cagtctctct cctcacaaaa atctgcccgt ggatatgcag ctgaagaagg aaaagaaatg     1740

tgtgaaactc ataggagttc ccgctgacgc tgaggcctta agtgaaagaa gtggaaacac     1800

ccctaactct cccaggttag ctgctgaatc aaagcttcaa acagaagtta aagaaggaaa     1860

agaaacttca agcaaattgg aaaaagaaac ttgtaagaaa tcacacccta ttctatatgt     1920

gtcttctaaa tctactccag agacccagtg ccctcaacag taaagacttt tctttaataa     1980

gagtacggtg ccacttgcct caaaagttac tatggtgctt aagattgtct tgatctgaca     2040

tatatcacct tctgggttat ttactcattg tgccaggacc tggcattttc atgtgccttt     2100

gaccaagtgt tcagaatttg cttgactcta acctggagag cttcttaagt gatgcccctt     2160

catggagctt ctatgacagt gaataaacta ttaattgaag gaaaatgtta taattaatgt     2220

atctatttgc tgcattgtat atggattaaa tgataaaaaa caagtaatct accctcagag     2280

ccatgtattt gagaatgctt caatcatatt ttcctatgta ctttttttta taaacttagt     2340

tttagactat gttgtaaaaa tgggaaggtt gtaaactatg ttgtaaaaat aggaaatgtg     2400

gcttaaaata tatacattat attgtttcag gattttgtca gtgtttaaag aaccaatgtt     2460

catctttgta tttatataca tgatttaaat tttgtctaaa attttaaata aaactgcagt     2520

gatttatccg taaaaaaaaa aaaaaaaaaa aaaaaaaaaa a                         2561


<210>  701
<211>  605
<212>  PRT
<213>  Homo sapiens

<400>  701

Met Glu Ala Asp Ile Ile Thr Asn Leu Arg Cys Arg Leu Lys Glu Ala 
1               5                   10                  15      


Glu Glu Glu Arg Leu Lys Ala Ala Gln Tyr Gly Leu Gln Leu Val Glu 
            20                  25                  30          


Ser Gln Asn Glu Leu Gln Asn Gln Leu Asp Lys Cys Arg Asn Glu Met 
        35                  40                  45              


Met Thr Met Thr Glu Ser Tyr Glu Gln Glu Lys Tyr Thr Leu Gln Arg 
    50                  55                  60                  


Glu Val Glu Leu Lys Ser Arg Met Leu Glu Ser Leu Ser Cys Glu Cys 
65                  70                  75                  80  


Glu Ala Ile Lys Gln Gln Gln Lys Met His Leu Glu Lys Leu Glu Glu 
                85                  90                  95      


Gln Leu Ser Arg Ser His Gly Gln Glu Val Asn Glu Leu Lys Thr Lys 
            100                 105                 110         


Ile Glu Lys Leu Lys Val Glu Leu Asp Glu Ala Arg Leu Ser Glu Lys 
        115                 120                 125             


Gln Leu Lys His Gln Val Asp His Gln Lys Glu Leu Leu Ser Cys Lys 
    130                 135                 140                 


Ser Glu Glu Leu Arg Val Met Ser Glu Arg Val Gln Glu Ser Met Ser 
145                 150                 155                 160 


Ser Glu Met Leu Ala Leu Gln Ile Glu Leu Thr Glu Met Glu Ser Met 
                165                 170                 175     


Lys Thr Thr Leu Lys Glu Glu Val Asn Glu Leu Gln Tyr Arg Gln Glu 
            180                 185                 190         


Gln Leu Glu Leu Leu Ile Thr Asn Leu Met Arg Gln Val Asp Arg Leu 
        195                 200                 205             


Lys Glu Glu Lys Glu Glu Arg Glu Lys Glu Ala Val Ser Tyr Tyr Asn 
    210                 215                 220                 


Ala Leu Glu Lys Ala Arg Val Ala Asn Gln Asp Leu Gln Val Gln Leu 
225                 230                 235                 240 


Asp Gln Ala Leu Gln Gln Ala Leu Asp Pro Asn Ser Lys Gly Asn Ser 
                245                 250                 255     


Leu Phe Ala Glu Val Glu Asp Arg Arg Ala Ala Met Glu Arg Gln Leu 
            260                 265                 270         


Ile Ser Met Lys Val Lys Tyr Gln Ser Leu Lys Lys Gln Asn Val Phe 
        275                 280                 285             


Asn Arg Glu Gln Met Gln Arg Met Lys Leu Gln Ile Ala Thr Leu Leu 
    290                 295                 300                 


Gln Met Lys Gly Ser Gln Thr Glu Phe Glu Gln Gln Glu Arg Leu Leu 
305                 310                 315                 320 


Ala Met Leu Glu Gln Lys Asn Gly Glu Ile Lys His Leu Leu Gly Glu 
                325                 330                 335     


Ile Arg Asn Leu Glu Lys Phe Lys Asn Leu Tyr Asp Ser Met Glu Ser 
            340                 345                 350         


Lys Pro Ser Val Asp Ser Gly Thr Leu Glu Asp Asn Thr Tyr Tyr Thr 
        355                 360                 365             


Asp Leu Leu Gln Met Lys Leu Asp Asn Leu Asn Lys Glu Ile Glu Ser 
    370                 375                 380                 


Thr Lys Gly Glu Leu Ser Ile Gln Arg Met Lys Ala Leu Phe Glu Ser 
385                 390                 395                 400 


Gln Arg Ala Leu Asp Ile Glu Arg Lys Leu Phe Ala Asn Glu Arg Cys 
                405                 410                 415     


Leu Gln Leu Ser Glu Ser Glu Asn Met Lys Leu Arg Ala Lys Leu Asp 
            420                 425                 430         


Glu Leu Lys Leu Lys Tyr Glu Pro Glu Glu Thr Val Glu Val Pro Val 
        435                 440                 445             


Leu Lys Lys Arg Arg Glu Val Leu Pro Val Asp Ile Thr Thr Ala Lys 
    450                 455                 460                 


Asp Ala Cys Val Asn Asn Ser Ala Leu Gly Gly Glu Val Tyr Arg Leu 
465                 470                 475                 480 


Pro Pro Gln Lys Glu Glu Thr Gln Ser Cys Pro Asn Ser Leu Glu Asp 
                485                 490                 495     


Asn Asn Leu Gln Leu Glu Lys Ser Val Ser Ile Tyr Thr Pro Val Val 
            500                 505                 510         


Ser Leu Ser Pro His Lys Asn Leu Pro Val Asp Met Gln Leu Lys Lys 
        515                 520                 525             


Glu Lys Lys Cys Val Lys Leu Ile Gly Val Pro Ala Asp Ala Glu Ala 
    530                 535                 540                 


Leu Ser Glu Arg Ser Gly Asn Thr Pro Asn Ser Pro Arg Leu Ala Ala 
545                 550                 555                 560 


Glu Ser Lys Leu Gln Thr Glu Val Lys Glu Gly Lys Glu Thr Ser Ser 
                565                 570                 575     


Lys Leu Glu Lys Glu Thr Cys Lys Lys Leu His Pro Ile Leu Tyr Val 
            580                 585                 590         


Ser Ser Lys Ser Thr Pro Glu Thr Gln Cys Pro Gln Gln 
        595                 600                 605 


<210>  702
<211>  605
<212>  PRT
<213>  Homo sapiens

<400>  702

Met Glu Ala Asp Ile Ile Thr Asn Leu Arg Cys Arg Leu Lys Glu Ala 
1               5                   10                  15      


Glu Glu Glu Arg Leu Lys Ala Ala Gln Tyr Gly Leu Gln Leu Val Glu 
            20                  25                  30          


Ser Gln Asn Glu Leu Gln Asn Gln Leu Asp Lys Cys Arg Asn Glu Met 
        35                  40                  45              


Met Thr Met Thr Glu Ser Tyr Glu Gln Glu Lys Tyr Thr Leu Gln Arg 
    50                  55                  60                  


Glu Val Glu Leu Lys Ser Arg Met Leu Glu Ser Leu Ser Cys Glu Cys 
65                  70                  75                  80  


Glu Ala Ile Lys Gln Gln Gln Lys Met His Leu Glu Lys Leu Glu Glu 
                85                  90                  95      


Gln Leu Ser Arg Ser His Gly Gln Glu Val Asn Glu Leu Lys Thr Lys 
            100                 105                 110         


Ile Glu Lys Leu Lys Val Glu Leu Asp Glu Ala Arg Leu Ser Glu Lys 
        115                 120                 125             


Gln Leu Lys His Gln Val Asp His Gln Lys Glu Leu Leu Ser Cys Lys 
    130                 135                 140                 


Ser Glu Glu Leu Arg Val Met Ser Glu Arg Val Gln Glu Ser Met Ser 
145                 150                 155                 160 


Ser Glu Met Leu Ala Leu Gln Ile Glu Leu Thr Glu Met Glu Ser Met 
                165                 170                 175     


Lys Thr Thr Leu Lys Glu Glu Val Asn Glu Leu Gln Tyr Arg Gln Glu 
            180                 185                 190         


Gln Leu Glu Leu Leu Ile Thr Asn Leu Met Arg Gln Val Asp Arg Leu 
        195                 200                 205             


Lys Glu Glu Lys Glu Glu Arg Glu Lys Glu Ala Val Ser Tyr Tyr Asn 
    210                 215                 220                 


Ala Leu Glu Lys Ala Arg Val Ala Asn Gln Asp Leu Gln Val Gln Leu 
225                 230                 235                 240 


Asp Gln Ala Leu Gln Gln Ala Leu Asp Pro Asn Ser Lys Gly Asn Ser 
                245                 250                 255     


Leu Phe Ala Glu Val Glu Asp Arg Arg Ala Ala Met Glu Arg Gln Leu 
            260                 265                 270         


Ile Ser Met Lys Val Lys Tyr Gln Ser Leu Lys Lys Gln Asn Val Phe 
        275                 280                 285             


Asn Arg Glu Gln Met Gln Arg Met Lys Leu Gln Ile Ala Thr Leu Leu 
    290                 295                 300                 


Gln Met Lys Gly Ser Gln Thr Glu Phe Glu Gln Gln Glu Arg Leu Leu 
305                 310                 315                 320 


Ala Met Leu Glu Gln Lys Asn Gly Glu Ile Lys His Leu Leu Gly Glu 
                325                 330                 335     


Ile Arg Asn Leu Glu Lys Phe Lys Asn Leu Tyr Asp Ser Met Glu Ser 
            340                 345                 350         


Lys Pro Ser Val Asp Ser Gly Thr Leu Glu Asp Asn Thr Tyr Tyr Thr 
        355                 360                 365             


Asp Leu Leu Gln Met Lys Leu Asp Asn Leu Asn Lys Glu Ile Glu Ser 
    370                 375                 380                 


Thr Lys Gly Glu Leu Ser Ile Gln Arg Met Lys Ala Leu Phe Glu Ser 
385                 390                 395                 400 


Gln Arg Ala Leu Asp Ile Glu Arg Lys Leu Phe Ala Asn Glu Arg Cys 
                405                 410                 415     


Leu Gln Leu Ser Glu Ser Glu Asn Met Lys Leu Arg Ala Lys Leu Asp 
            420                 425                 430         


Glu Leu Lys Leu Lys Tyr Glu Pro Glu Glu Thr Val Glu Val Pro Val 
        435                 440                 445             


Leu Lys Lys Arg Arg Glu Val Leu Pro Val Asp Ile Thr Thr Ala Lys 
    450                 455                 460                 


Asp Ala Cys Val Asn Asn Ser Ala Leu Gly Gly Glu Val Tyr Arg Leu 
465                 470                 475                 480 


Pro Pro Gln Lys Glu Glu Thr Gln Ser Cys Pro Asn Ser Leu Glu Asp 
                485                 490                 495     


Asn Asn Leu Gln Leu Glu Lys Ser Val Ser Ile His Thr Pro Val Val 
            500                 505                 510         


Ser Leu Ser Pro His Lys Asn Leu Pro Val Asp Met Gln Leu Lys Lys 
        515                 520                 525             


Glu Lys Lys Cys Val Lys Leu Ile Gly Val Pro Ala Asp Ala Glu Ala 
    530                 535                 540                 


Leu Ser Glu Arg Ser Gly Asn Thr Pro Asn Ser Pro Arg Leu Ala Ala 
545                 550                 555                 560 


Glu Ser Lys Leu Gln Thr Glu Val Lys Glu Gly Lys Glu Thr Ser Ser 
                565                 570                 575     


Lys Leu Glu Lys Glu Thr Cys Lys Lys Ser His Pro Ile Leu Tyr Val 
            580                 585                 590         


Ser Ser Lys Ser Thr Pro Glu Thr Gln Cys Pro Gln Gln 
        595                 600                 605 


<210>  703
<211>  2116
<212>  DNA
<213>  Homo sapiens

<400>  703
cggttctcca agcacccagc atcctgctag acgcgccgcg caccgacgga ggggacatgg       60

gcagagcaat ggtggccagg ctggggctgg ggctgctgct gctggcactg ctcctaccca      120

cgcagattta ttccagtgaa acaacaactg gaacttcaag taactcctcc cagagtactt      180

ccaactctgg gttggcccca aatccaacta atgccaccac caaggcggct ggtggtgccc      240

tgcagtcaac agccagtctc ttcgtggtct cactctctct tctgcatctc tactcttaag      300

agactcaggc caagaaacgt cttctaaatt tccccatctt ctaaacccaa tccaaatggc      360

gtctggaagt ccaatgtggc aaggaaaaac aggtcttcat cgaatctact aattccacac      420

cttttattga cacagaaaat gttgagaatc ccaaatttga ttgatttgaa gaacatgtga      480

gaggtttgac tagatgatga atgccaatat taaatctgct ggagtttcat gtacaagatg      540

aaggagaggc aacatccaaa atagttaaga catgatttcc ttgaatgtgg cttgagaaat      600

atggacactt aatactacct tgaaaataag aatagaaata aaggatggga ttgtggaatg      660

gagattcagt tttcattggt tcattaattc tataaggcca taaaacaggt aatataaaaa      720

gcttccatcg atctatttat atgtacatga gaaggaatcc ccaggtgtta ctgtaattcc      780

tcaacgtatt gtttcgacgg cactaattta atgccgatat actctagatg aatgtttaca      840

ttgttgagct attgctgttc tcttgggaac tgaactcact ttcctcctga ggctttggat      900

ttgacattgc atttgacctt ttaggtagta attgacatgt gccagggcaa tgatgaatga      960

gaatctaccc cagatccaag catcctgagc aactcttgat tatccatatt gagtcaaatg     1020

gtaggcattt cctatcacct gtttccattc aacaagagca ctacattctt ttagctaaac     1080

ggattccaaa gagtagaatt gcattgacca cgactaattt caaaatgctt tttattatta     1140

ttatttttta gacagtctca ctttgtcgcc caggccggag tgcagtggtg cgatctcaga     1200

tcagtgtacc atttgcctcc cgggctcaag cgattctcct gcctcagcct cccaagtagc     1260

tgggattaca ggcacctgcc accatgcccg gctaattttt gtaattttag tagagacagg     1320

gtttcaccat gttgcccagg ctggtttaga actcctgacc tcaggtgatc cacccgcctc     1380

ggcctcccaa agtgctggga ttacaggctt gagcccccgc gcccagccat caaaatgctt     1440

tttatttctg catatgtttg aatacttttt acaatttaaa aaaatgatct gttttgaagg     1500

caaaattgca aatcttgaaa ttaagaaggc aaaatgtaaa ggagtcaaac tataaatcaa     1560

gtatttggga agtgaagact ggaagctaat ttgcataaat tcacaaactt ttatactctt     1620

tctgtatata catttttttt ctttaaaaaa caactatgga tcagaatagc aacatttaga     1680

acactttttg ttatcagtca atatttttag atagttagaa cctggtccta agcctaaaag     1740

tgggcttgat tctgcagtaa atcttttaca actgcctcga cacacataaa cctttttaaa     1800

aatagacact ccccgaagtc ttttgtttgt atggtcacac actgatgctt agatgttcca     1860

gtaatctaat atggccacag tagtcttgat gaccaaagtc ctttttttcc atctttagaa     1920

aactacatgg gaacaaacag atcgaacagt tttgaagcta ctgtgtgtgt gaatgaacac     1980

tcttgcttta ttccagaatg ctgtacatct attttggatt gtatattgtg gttgtgtatt     2040

tacgctttga ttcatagtaa cttcttatgg aattgatttg cattgaacga caaactgtaa     2100

ataaaaagaa acggtg                                                     2116


<210>  704
<211>  80
<212>  PRT
<213>  Homo sapiens

<400>  704

Met Gly Arg Ala Met Val Ala Arg Leu Gly Leu Gly Leu Leu Leu Leu 
1               5                   10                  15      


Ala Leu Leu Leu Pro Thr Gln Ile Tyr Ser Ser Glu Thr Thr Thr Gly 
            20                  25                  30          


Thr Ser Ser Asn Ser Ser Gln Ser Thr Ser Asn Thr Gly Leu Ala Pro 
        35                  40                  45              


Asn Pro Thr Asn Ala Thr Thr Lys Ala Ala Gly Gly Ala Leu Gln Ser 
    50                  55                  60                  


Thr Ala Ser Leu Phe Val Val Ser Leu Ser Leu Leu His Leu Tyr Ser 
65                  70                  75                  80  


<210>  705
<211>  80
<212>  PRT
<213>  Homo sapiens

<400>  705

Met Gly Arg Ala Met Val Ala Arg Leu Gly Leu Gly Leu Leu Leu Leu 
1               5                   10                  15      


Ala Leu Leu Leu Pro Thr Gln Ile Tyr Ser Ser Glu Thr Thr Thr Gly 
            20                  25                  30          


Thr Ser Ser Asn Ser Ser Gln Ser Thr Ser Asn Ser Gly Leu Ala Pro 
        35                  40                  45              


Asn Pro Thr Asn Ala Thr Thr Lys Ala Ala Gly Gly Ala Leu Gln Ser 
    50                  55                  60                  


Thr Ala Ser Leu Phe Val Val Ser Leu Ser Leu Leu His Leu Tyr Ser 
65                  70                  75                  80  


<210>  706
<211>  1944
<212>  DNA
<213>  Homo sapiens

<400>  706
cggaagtcgc ttgtgtatga acgcagcggc ggacctgtga ggggatccga cttgccggca       60

gaacttacgc tgcgggaccc cgggcactgt tgctgctgcg ggagtccaga gaggcaggag      120

gatggagctc ggaaggattt cagctccagg ctggctgctg gaccgacttt tcaacatttt      180

ttaaaaagtg cctcagctcc tcaggagaag ctgtcttcag aagtggaaga cccacctccc      240

tatctcatga tggatgaact tcttggaagg cagagaaaag tctacctcga gacctatggc      300

tgccagatga atgtgaatga cacagagata gcctggtcca tcttacagaa gagtggctac      360

ctgcggacca gtaacctcca agaggcagat gtgattctcc ttgtcacatg ctctatcagg      420

gagaaggctg agcagaccat ctggaaccgt ttacatcagc ttaaagcctt gaagacaagg      480

cggccccgct cccgggttcc tctgaggatt ggaattctag gctgcatggc tgagaggttg      540

aaggaggaga ttctcaacag agagaaaatg gtagatattt tggctggtcc tgatgcctac      600

cgggaccttc cccggctgct ggctgttgct gagtcgggcc agcaagctgc caacgtgctg      660

ctctctctgg acgagaccta tgctgatgtc atgccagtcc agacaagcgc cagtgccacg      720

tctgcctttg tgtcaatcat gcgaggctgt gacaacatgt gtagctactg cattgttcct      780

ttcacccggg gcagggagag gagtcggcct attgcctcca ttctagagga agtgaagaag      840

ctttctgagc aggggctgaa agaagtgaca cttcttggtc agaatgttaa tagttttcgg      900

gacaattcgg aggtccagtt caacagtgca gtgcctacca atctcagtcg tggctttacc      960

accaactata aaaccaagca aggaggactt cgttttgctc atcttctgga tcaggtctcc     1020

agagtagatc ctgaaatgag gatccgtttt acctctcccc accccaagga ttttcctgat     1080

gaggttctgc agctgattca tgagagagat aacatctgta aacagatcca cctgccagcc     1140

cagagtggaa gcagccgtgt gttggaggcc atgcggaggg gatattcaag agaagcttat     1200

gtggagttag ttcaccatat tagagaatct attccaggtg tgagcctcag cagcgatttc     1260

attgctggct tttgtggtga gacggaggaa gatcacgtcc agacagtctc tttgctccgg     1320

gaagttcagt acaacatggg cttcctcttt gcctacagca tgagacagaa gacacgggca     1380

tatcataggc tgaaggatga tgtcccggaa gaggtaaaat taaggcgttt ggaggaactc     1440

atcactatct tccgagaaga agcaacaaaa gccaatcaga cctctgtggg ctgtacccag     1500

ttggtgctag tggaagggct cagtaaacgc tctgccactg acctgtgtgg caggaatgat     1560

ggaaacctta aggtgatctt ccctgatgca gagatggagg atgtcaataa ccctgggctc     1620

agggtcagag cccagcctgg ggactatgtg ctggtgaaga tcacctcagc cagttctcag     1680

acacttaggg gacatgttct ctgcaggacc actctgaggg actcttctgc atattgctga     1740

cctgagagga tggcctcaga gctgacttgg gcaatcctcc ccaacaggaa ggggagacat     1800

tgcctgccac tgaggaaaca ggtcatgaag gtggagataa gctgcaaggg gcgaagcaac     1860

tttatgtcag tggaaaacgt gtctctttaa agctgctatg tgaacagctt ttacagtcat     1920

taaatttacc taaactaagg ttaa                                            1944


<210>  707
<211>  601
<212>  PRT
<213>  Homo sapiens

<400>  707

Met His Pro Leu Gln Cys Val Leu Gln Val Gln Arg Ser Leu Gly Trp 
1               5                   10                  15      


Gly Pro Leu Ala Ser Val Ser Trp Leu Ser Leu Arg Met Cys Arg Ala 
            20                  25                  30          


His Ser Ser Leu Ser Ser Thr Met Cys Pro Ser Pro Glu Arg Gln Glu 
        35                  40                  45              


Asp Gly Ala Arg Lys Asp Phe Ser Ser Arg Leu Ala Ala Gly Pro Thr 
    50                  55                  60                  


Phe Gln His Phe Leu Lys Ser Ala Ser Ala Pro Gln Glu Lys Leu Ser 
65                  70                  75                  80  


Ser Glu Val Glu Asp Pro Pro Pro Tyr Leu Met Met Asp Glu Leu Leu 
                85                  90                  95      


Gly Arg Gln Arg Lys Val Tyr Leu Glu Thr Tyr Gly Cys Gln Met Asn 
            100                 105                 110         


Val Asn Asp Thr Glu Ile Ala Trp Ser Ile Leu Gln Lys Ser Gly Tyr 
        115                 120                 125             


Leu Arg Thr Ser Asn Leu Gln Glu Ala Asp Val Ile Leu Leu Val Thr 
    130                 135                 140                 


Cys Ser Ile Arg Glu Lys Ala Glu Gln Thr Ile Trp Asn Arg Leu His 
145                 150                 155                 160 


Gln Leu Lys Ala Leu Lys Thr Arg Arg Pro Arg Ser Arg Val Pro Leu 
                165                 170                 175     


Arg Ile Gly Ile Leu Gly Cys Met Ala Glu Arg Leu Lys Glu Glu Ile 
            180                 185                 190         


Leu Asn Arg Glu Lys Met Val Asp Ile Leu Ala Gly Pro Asp Ala Tyr 
        195                 200                 205             


Arg Asp Leu Pro Arg Leu Leu Ala Val Ala Glu Ser Gly Gln Gln Ala 
    210                 215                 220                 


Ala Asn Val Leu Leu Ser Leu Asp Glu Thr Tyr Ala Asp Val Met Pro 
225                 230                 235                 240 


Val Gln Thr Ser Ala Ser Ala Thr Ser Ala Phe Val Ser Ile Met Arg 
                245                 250                 255     


Gly Cys Asp Asn Met Cys Ser Tyr Cys Ile Val Pro Phe Thr Arg Gly 
            260                 265                 270         


Arg Glu Arg Ser Arg Pro Ile Ala Ser Ile Leu Glu Glu Val Lys Lys 
        275                 280                 285             


Leu Ser Glu Gln Val Phe Leu Pro Pro Arg Pro Pro Lys Val Leu Gly 
    290                 295                 300                 


Leu Gln Gly Leu Lys Glu Val Thr Leu Leu Gly Gln Asn Val Asn Ser 
305                 310                 315                 320 


Phe Arg Asp Asn Ser Glu Val Gln Phe Asn Ser Ala Val Pro Thr Asn 
                325                 330                 335     


Leu Ser Arg Gly Phe Thr Thr Asn Tyr Lys Thr Lys Gln Gly Gly Leu 
            340                 345                 350         


Arg Phe Ala His Leu Leu Asp Gln Val Ser Arg Val Asp Pro Glu Met 
        355                 360                 365             


Arg Ile Arg Phe Thr Ser Pro His Pro Lys Asp Phe Pro Asp Glu Val 
    370                 375                 380                 


Leu Gln Leu Ile His Glu Arg Asp Asn Ile Cys Lys Gln Ile His Leu 
385                 390                 395                 400 


Pro Ala Gln Ser Gly Ser Ser Arg Val Leu Glu Ala Met Arg Arg Gly 
                405                 410                 415     


Tyr Ser Arg Glu Ala Tyr Val Glu Leu Val His His Ile Arg Glu Ser 
            420                 425                 430         


Ile Pro Gly Val Ser Leu Ser Ser Asp Phe Ile Ala Gly Phe Cys Gly 
        435                 440                 445             


Glu Thr Glu Glu Asp His Val Gln Thr Val Ser Leu Leu Arg Glu Val 
    450                 455                 460                 


Gln Tyr Asn Met Gly Phe Leu Phe Ala Tyr Ser Met Arg Gln Lys Thr 
465                 470                 475                 480 


Arg Ala Tyr His Arg Leu Lys Asp Asp Val Pro Glu Glu Val Lys Leu 
                485                 490                 495     


Arg Arg Leu Glu Glu Leu Ile Thr Ile Phe Arg Glu Glu Ala Thr Lys 
            500                 505                 510         


Ala Asn Gln Thr Ser Val Gly Cys Thr Gln Leu Val Leu Val Glu Gly 
        515                 520                 525             


Leu Ser Lys Arg Ser Ala Thr Asp Leu Cys Gly Arg Asn Asp Gly Asn 
    530                 535                 540                 


Leu Lys Val Ile Phe Pro Asp Ala Glu Met Glu Asp Val Asn Asn Pro 
545                 550                 555                 560 


Gly Leu Arg Val Arg Ala Gln Pro Gly Asp Tyr Val Leu Val Lys Ile 
                565                 570                 575     


Thr Ser Ala Ser Ser Gln Thr Leu Arg Gly His Val Leu Cys Arg Thr 
            580                 585                 590         


Thr Leu Arg Asp Ser Ser Ala Tyr Cys 
        595                 600     


<210>  708
<211>  497
<212>  PRT
<213>  Homo sapiens

<400>  708

Met Met Asp Glu Leu Leu Gly Arg Gln Arg Lys Val Tyr Leu Glu Thr 
1               5                   10                  15      


Tyr Gly Cys Gln Met Asn Val Asn Asp Thr Glu Ile Ala Trp Ser Ile 
            20                  25                  30          


Leu Gln Lys Ser Gly Tyr Leu Arg Thr Ser Asn Leu Gln Glu Ala Asp 
        35                  40                  45              


Val Ile Leu Leu Val Thr Cys Ser Ile Arg Glu Lys Ala Glu Gln Thr 
    50                  55                  60                  


Ile Trp Asn Arg Leu His Gln Leu Lys Ala Leu Lys Thr Arg Arg Pro 
65                  70                  75                  80  


Arg Ser Arg Val Pro Leu Arg Ile Gly Ile Leu Gly Cys Met Ala Glu 
                85                  90                  95      


Arg Leu Lys Glu Glu Ile Leu Asn Arg Glu Lys Met Val Asp Ile Leu 
            100                 105                 110         


Ala Gly Pro Asp Ala Tyr Arg Asp Leu Pro Arg Leu Leu Ala Val Ala 
        115                 120                 125             


Glu Ser Gly Gln Gln Ala Ala Asn Val Leu Leu Ser Leu Asp Glu Thr 
    130                 135                 140                 


Tyr Ala Asp Val Met Pro Val Gln Thr Ser Ala Ser Ala Thr Ser Ala 
145                 150                 155                 160 


Phe Val Ser Ile Met Arg Gly Cys Asp Asn Met Cys Ser Tyr Cys Ile 
                165                 170                 175     


Val Pro Phe Thr Arg Gly Arg Glu Arg Ser Arg Pro Ile Ala Ser Ile 
            180                 185                 190         


Leu Glu Glu Val Lys Lys Leu Ser Glu Gln Gly Leu Lys Glu Val Thr 
        195                 200                 205             


Leu Leu Gly Gln Asn Val Asn Ser Phe Arg Asp Asn Ser Glu Val Gln 
    210                 215                 220                 


Phe Asn Ser Ala Val Pro Thr Asn Leu Ser Arg Gly Phe Thr Thr Asn 
225                 230                 235                 240 


Tyr Lys Thr Lys Gln Gly Gly Leu Arg Phe Ala His Leu Leu Asp Gln 
                245                 250                 255     


Val Ser Arg Val Asp Pro Glu Met Arg Ile Arg Phe Thr Ser Pro His 
            260                 265                 270         


Pro Lys Asp Phe Pro Asp Glu Val Leu Gln Leu Ile His Glu Arg Asp 
        275                 280                 285             


Asn Ile Cys Lys Gln Ile His Leu Pro Ala Gln Ser Gly Ser Ser Arg 
    290                 295                 300                 


Val Leu Glu Ala Met Arg Arg Gly Tyr Ser Arg Glu Ala Tyr Val Glu 
305                 310                 315                 320 


Leu Val His His Ile Arg Glu Ser Ile Pro Gly Val Ser Leu Ser Ser 
                325                 330                 335     


Asp Phe Ile Ala Gly Phe Cys Gly Glu Thr Glu Glu Asp His Val Gln 
            340                 345                 350         


Thr Val Ser Leu Leu Arg Glu Val Gln Tyr Asn Met Gly Phe Leu Phe 
        355                 360                 365             


Ala Tyr Ser Met Arg Gln Lys Thr Arg Ala Tyr His Arg Leu Lys Asp 
    370                 375                 380                 


Asp Val Pro Glu Glu Val Lys Leu Arg Arg Leu Glu Glu Leu Ile Thr 
385                 390                 395                 400 


Ile Phe Arg Glu Glu Ala Thr Lys Ala Asn Gln Thr Ser Val Gly Cys 
                405                 410                 415     


Thr Gln Leu Val Leu Val Glu Gly Leu Ser Lys Arg Ser Ala Thr Asp 
            420                 425                 430         


Leu Cys Gly Arg Asn Asp Gly Asn Leu Lys Val Ile Phe Pro Asp Ala 
        435                 440                 445             


Glu Met Glu Asp Val Asn Asn Pro Gly Leu Arg Val Arg Ala Gln Pro 
    450                 455                 460                 


Gly Asp Tyr Val Leu Val Lys Ile Thr Ser Ala Ser Ser Gln Thr Leu 
465                 470                 475                 480 


Arg Gly His Val Leu Cys Arg Thr Thr Leu Arg Asp Ser Ser Ala Tyr 
                485                 490                 495     


Cys 
    


<210>  709
<211>  1161
<212>  DNA
<213>  Homo sapiens

<400>  709
ggggggcggt gccgttggga ccacggcggc cagagcggca ggatggcttc cggcttcaag       60

aagcccagcg ctgcctccac cggccaaaag agaaaggtgg cacctaagcc cgagctcact      120

gaggatcaga agcaagaagt tcgggaagca tttgacctct tcgacgtgga cggaagtggg      180

accatcgacg cgaaggagct gaaggtggcc atgagagcgc tgggcttcga acccaggaag      240

gaagagatga agaaaatgat ctccgaggtg gacagggaag gcacggggaa gatcagcttc      300

aatgacttcc tggccgtgat gacgcagaag atgtccgaga aggacaccaa agaagaaatc      360

ctgaaggcct tcaggctctt tgatgacgat gagaccggga agatctcgtt caaaaacctg      420

aagcgtgtgg ccaacgagct gggggagaac ctcacggatg aggagctgca ggagatgatc      480

gacgaagctg atcgggatgg ggacggcgaa gtgaacgagg aggagttcct tcggatcatg      540

aagaagacca gcctttactg aagtcggttc agaagctaaa gtgactctct gggttgcctg      600

cttccatttt gtgaaacctt agaggacagc ggctgcctgt cccttcttca ccccctcacc      660

cccataattt gtctagatct atttccatat ctctagttca ataatagaat ttgaaagatg      720

cttgtaatgt gagttttggg ttttaattct caagagccaa cctggagcac atgaggttaa      780

acaaagggcc ctgaagtttg agtgcgccct ccatttgccc tgtgctgaac ttgctgttca      840

tctgttgatc tggaggcagg acagcttctg ggacacacaa aaatgtggtt ccctttgtca      900

cttctttggt ggtcttaaat tatcttgctt catatatcat tccttaaatt ccagtcattg      960

ttccagcata atgagatgga atctgccagt agatttgcct agcctgtcca cttagctgaa     1020

taccagtttg aaggaaaaca gggtggccac ttacaaactt acggagctca ggacagatat     1080

tcttataaag aatagacttg cttgggtggt agtacgttgt gcaattttga ctattcactg     1140

gctttatacc tgcaaatgcc c                                               1161


<210>  710
<211>  172
<212>  PRT
<213>  Homo sapiens

<400>  710

Met Ala Ser Gly Phe Lys Lys Pro Ser Ala Ala Ser Thr Gly Gln Lys 
1               5                   10                  15      


Arg Lys Val Ala Pro Lys Pro Glu Leu Thr Glu Asp Gln Lys Gln Glu 
            20                  25                  30          


Val Arg Glu Ala Phe Asp Leu Phe Asp Val Asp Gly Ser Gly Thr Ile 
        35                  40                  45              


Asp Ala Lys Glu Leu Lys Val Ala Met Arg Ala Leu Gly Phe Glu Pro 
    50                  55                  60                  


Arg Lys Glu Glu Met Lys Lys Met Ile Ser Glu Val Asp Arg Glu Gly 
65                  70                  75                  80  


Thr Gly Lys Ile Ser Phe Asn Asp Phe Leu Ala Val Met Thr Gln Lys 
                85                  90                  95      


Met Ser Glu Lys Asp Thr Lys Glu Glu Ile Leu Lys Ala Phe Arg Leu 
            100                 105                 110         


Phe Asp Asp Asp Glu Thr Gly Lys Ile Ser Phe Lys Asn Leu Lys Arg 
        115                 120                 125             


Val Ala Asn Glu Leu Gly Glu Asn Leu Thr Asp Glu Glu Leu Gln Glu 
    130                 135                 140                 


Met Ile Asp Glu Ala Asp Arg Asp Gly Asp Gly Glu Val Asn Glu Glu 
145                 150                 155                 160 


Glu Phe Leu Arg Ile Met Lys Lys Thr Ser Leu Tyr 
                165                 170         


<210>  711
<211>  172
<212>  PRT
<213>  Homo sapiens

<400>  711

Met Ala Ser Gly Phe Lys Lys Pro Ser Ala Ala Ser Thr Gly Gln Lys 
1               5                   10                  15      


Arg Lys Val Ala Pro Lys Pro Glu Leu Thr Glu Asp Gln Lys Gln Glu 
            20                  25                  30          


Val Arg Glu Ala Phe Asp Leu Phe Asp Val Asp Gly Ser Gly Thr Ile 
        35                  40                  45              


Asp Ala Lys Glu Leu Lys Val Ala Met Arg Ala Leu Gly Phe Glu Pro 
    50                  55                  60                  


Arg Lys Glu Glu Met Lys Lys Met Ile Ser Glu Val Asp Arg Glu Gly 
65                  70                  75                  80  


Thr Gly Lys Ile Ser Phe Asn Asp Phe Leu Ala Val Met Thr Gln Lys 
                85                  90                  95      


Met Ser Glu Lys Asp Thr Lys Glu Glu Ile Leu Lys Ala Phe Arg Leu 
            100                 105                 110         


Phe Asp Asp Asp Glu Thr Gly Lys Ile Ser Phe Lys Asn Leu Lys Arg 
        115                 120                 125             


Val Ala Asn Glu Leu Gly Glu Asn Leu Thr Asp Glu Glu Leu Gln Glu 
    130                 135                 140                 


Met Ile Asp Glu Ala Asp Arg Asp Gly Asp Gly Glu Val Asn Glu Glu 
145                 150                 155                 160 


Glu Phe Leu Arg Ile Met Lys Lys Thr Ser Leu Tyr 
                165                 170         


<210>  712
<211>  4812
<212>  DNA
<213>  Homo sapiens

<400>  712
ctggctggct ggctgtacac ctcgctgccg ccgggcttcg ggggcaccgg ggaagactac       60

agcgaagagg ggatccactt cccgtggctg ccggcgctcg tgtgcaccgg cgcggtattc      120

ctgggcgccg aaatctgccc ctactcagtg tgttcgcggc acgggctggc catcgcctcg      180

cacagcgtgt gcctgacccg gcttctgatg gcagccgcct tccccgtgtg ctacccgctg      240

ggccgcctgc tggactgggc gctgcgccag gagataagca ccttctacac gcgggagaag      300

ttgctggaga cgttgcgggc cgcagacccc tacagtgacc tggtgaagga ggagctcaac      360

atcatacagg gtgccctgga gctgcgcacc aaagtggtgg aggaggtgct gacccccctg      420

ggagactgct tcatgctgcg ctcagacgcg gtgctcgact tcgccactgt ctccgagatc      480

ctgcgcagcg gctacactcg catcccagtg tacgagggtg accagcggca caacattgtg      540

gacattttat ttgtcaagga cttggccttc gtggaccccg acgactgcac cccgctcctc      600

actgtcaccc gcttctacaa ccggcccctg cattgtgttt tcaatgacac ccgactggac      660

acggttctgg aggagtttaa gaagggaaaa tctcacctgg ccattgtcca gcgggtgaat      720

aatgagggag aaggggaccc tttctatgag gtgatgggca ttgtcacgct ggaggatatc      780

atagaggaga ttatcaagtc ggagatcctg gatgaaactg atctctacac tgacaatcgg      840

aaaaagcaga gggtcccgca acgggagcgg aagcggcatg acttctcctt gtttaagctt      900

tcggacacgg agatgcgggt gaagatctca ccacagcttc tgctagccac acaccgcttc      960

atggccacag aagtggagcc ctttaagtct ctgtaccttt cggagaagat cctgctccgg     1020

ctcctgaaac atcccaacgt gatccaggag ctgaagtttg atgagaagaa caagaaggcc     1080

ccggaacact acctctacca gcgcaaccgc cctgtggact actttgtgct gcttctacag     1140

ggtaaagtgg aggtggaggt tggtaaggaa ggccttcgct ttgaaaatgg agcctttact     1200

tactatggcg tcccagccat catgaccact gcttgctcag ataatgacgt gcggaaggtt     1260

ggaagtctgg ctggatcttc tgtctttcta aaccggtccc cttctcgctg cagtgggttg     1320

aatcgctctg agtctccaaa ccgagagcgc agtgactttg ggggcagcaa cacccagctg     1380

tacagcagca gcaacaacct ctacatgcct gactactcag tccacatcct cagcgatgtg     1440

cagtttgtga agatcacacg gcagcaatat cagaacgcac tcactgcctg ccacatggac     1500

agctcacctc agtcccctga catggaggcc ttcacagacg gggactccac taaggccccc     1560

acaacccggg gcacacccca gacccctaag gatgaccccg ccatcacgct cctcaacaac     1620

aggaacagcc tgccgtgcag ccgctcagac gggctgagaa gccccagcga ggtagtgtac     1680

ctgaggatgg aggagctggc cttcacccag gaagaaatga ctgacttcga ggagcacagc     1740

acacagcagc tcacgctgtc tcctgcagcc gttcccacga gagcagcatc agatagtgaa     1800

tgttgtaaca tcaacctgga tacagagacc agcccctgca gtagcgattt tgaggaaaac     1860

gtgggcaaga agctgctgag aaccttgagt ggccaaaaaa ggaagaggtc accagaagga     1920

gagagaacct ctgaggacaa ctccaattta acacctctga tcacatgaca gggcaaagcc     1980

agcattcact gggtgtgtga aattccagag ctttggggga gaatccaccc tcccatcatc     2040

tgcttccccc aaggcctccc acaggtgaca gaatgttctg ccttcccttc catctcttca     2100

cccctagctg tcagtttggc agattttccc tcgttacctc cagttcgact cagaaccttg     2160

acatggccat aacagaagga ggtgcctctg atagaacatg ctagaaatgg tcttttccac     2220

agcatagtct gggactggaa aagagatgtc tgactgcaag ctgacaatgc cactctggga     2280

cccctgatgc tcttctttgt tctttgggtc ccctgatgcc ataggagacc tatcgtcttg     2340

gaacttgcca ttctttcctc cagaacaaaa tgttaacttt ctaacacatt tcatgcatag     2400

cttggctcag aaggtgccat tggcagacag gcacatggga ggctggagta ggaggtctga     2460

agattagttc aggggatgga ccaagaattt cccccagagc tttaaagaag tgggactcag     2520

ccatgttggc gcgtgattga cattacagca cagaaaactg ttagtgactg gtttcctgtt     2580

agataagggt tccagcagcc tggggcagta tgtctcagct ggaatggaaa gaatgtgaga     2640

tggaacctca agtcactgtt tttaccaggg acacatctgt tttggctccc aatcagcagt     2700

cttcaatcga tcaataattc tgctctggaa gagaaggaac agggagcaga gagacccaac     2760

tgggagccag agatggaact tcaggtctta agtgcaaatc aaagcaaaaa acaaacaaaa     2820

cttacatgga aaaactgtaa gtgctgaaag caagtttagc catgacaaac caaagagtgc     2880

ccaggtcagc caagaaagat acataatctc atgggacttc agtgggagtt acacaggaat     2940

gttgaagaat cattcttctt tttcatgcat ttgtccttct cccaccccct tactacaccc     3000

tagcagatca gctgagtgta ctttattcca agaacttact ggatctctgg tttttctcct     3060

gaagttgggg caggtgcaat tccaagcata accaccagat ggcagagtga ccgcgcatac     3120

ctgcttccaa gaataaaaca gttctgaaaa gcaaccgcaa agccgggcgc ggtggctcac     3180

acctgtaatc ccaacagttt ggaagaccga ggcgggtgga tcacttgaag tcaggagttt     3240

gagaccagcc tggccaacat ggtgaaaccc ccatctctcc tgggcatgta gtcccagcta     3300

ctcgggaggc tgaggcagga gaatcgcttg aacctgggag gcagaggttg cagtgagctg     3360

agatcacacc actgcacttc atcctaggca acagagcgag actctgtctc ccccctcaaa     3420

aaaaaaaaag aaagaaagaa agagaaaaga aaagaaaagc aaccacagcc agccttaggg     3480

aaaacttgga agtaagtgaa atttgtcttc agaataacta tctccctttc tgatctgtct     3540

cctactcttt agatgttctc agtcaagtac tcactgaact cattgatcga gtgctgtctg     3600

ctaaatctcc aaaccattcc caaacctttc cccgtagtat accatccagc ttccctcccc     3660

ttcctccaaa accctccctc ccacctcccc acacccattg agtcattcac aggcaggagg     3720

gagactgatc attcctctgg gttatctgca tctcaaaaga aaatgcttac ccacaggaac     3780

tgttaactca ggggttctta acttggggtc catcacccca gggggtccat agttggactt     3840

cagagggtct atgaaacccc taaaactgtc agtatttaat gtatttattc ttgtatgttt     3900

tttccagagc attaaagctt tcataaggtt ctcaaaggtc tcagacctac aaagagttaa     3960

aacaaacaga caaacaaaaa aaaacactac tattttaaat agtggaactt tcagcccagc     4020

gtttctgcaa tgcagagtga agtggatact gggcagttcg agacaggttt ttaatcataa     4080

gtggtctttt caaatgtcca tcaattgatg gggaaggctg gcacccacca agaagtggaa     4140

gtcctcagaa attctcggca caccctagag tattgtacaa ccaacacccc cacataactt     4200

tgtcccctct tccccaacaa cccagagcag gtgttgcaga caggagggcc acagcgtgtg     4260

gaagtaaaga ctttggagct agagatgcct tttccagcaa tgattattga cttcaccaca     4320

ccccttgcct ggcctggcct gaggctcagc agtgcatgac ttctcgtaga taacttcaca     4380

gtcatccagt cccaacacct gctcttgcct ggtaggaaca ggcgaagtgt cagccctcaa     4440

tgttgggtac ttagacccaa accaataaat ggtgagtttt gaacaagaac taccatcatg     4500

caggcttctt gcccagctga ccactggccc cggggtgcct gcctggctgg tcttcatcac     4560

ctgaggccac caggctcaag ccactgctgt tgcattacac ccatcccttt gcaaaatccc     4620

tatggagcct gtcaccactc ccctccctat atacccccac cccacaaaga ttttcttcag     4680

gttaaaaaaa aagtttaaaa aaaagatttt aaaataaagc atttatgaag gcttaataaa     4740

ttgtaaataa tttttaaata aaatgaaaat gcctttcctg gaaaaaaaaa aaaaaaaaaa     4800

aaaaaaaaaa aa                                                         4812


<210>  713
<211>  951
<212>  PRT
<213>  Homo sapiens

<400>  713

Met Ala Ala Ala Ala Ala Ala Ala Ala Ala Val Gly Val Arg Leu Arg 
1               5                   10                  15      


Asp Cys Cys Ser Arg Gly Ala Val Leu Leu Leu Phe Phe Ser Leu Ser 
            20                  25                  30          


Pro Arg Pro Pro Ala Ala Ala Ala Trp Leu Leu Gly Leu Arg Pro Glu 
        35                  40                  45              


Asp Thr Ala Gly Gly Arg Val Ser Leu Glu Gly Gly Thr Leu Arg Ala 
    50                  55                  60                  


Ala Glu Gly Thr Ser Phe Leu Leu Arg Val Tyr Phe Gln Pro Gly Pro 
65                  70                  75                  80  


Pro Ala Thr Ala Ala Pro Val Pro Ser Pro Thr Leu Asn Ser Gly Glu 
                85                  90                  95      


Asn Gly Thr Gly Asp Trp Ala Pro Arg Leu Val Phe Ile Glu Glu Pro 
            100                 105                 110         


Pro Gly Gly Gly Gly Val Ala Pro Ser Ala Val Pro Thr Arg Pro Pro 
        115                 120                 125             


Gly Pro Gln Arg Cys Arg Glu Gln Ser Asp Trp Ala Ser Asp Val Glu 
    130                 135                 140                 


Val Leu Gly Pro Leu Arg Pro Gly Gly Val Ala Gly Ser Ala Leu Val 
145                 150                 155                 160 


Gln Val Arg Val Arg Glu Leu Arg Lys Gly Glu Ala Glu Arg Gly Gly 
                165                 170                 175     


Ala Gly Gly Gly Gly Lys Leu Phe Ser Leu Cys Ala Trp Asp Gly Arg 
            180                 185                 190         


Ala Trp His His His Gly Ala Ala Gly Gly Phe Leu Leu Arg Val Arg 
        195                 200                 205             


Pro Arg Leu Tyr Gly Pro Gly Gly Asp Leu Leu Pro Pro Ala Trp Leu 
    210                 215                 220                 


Arg Ala Leu Gly Ala Leu Leu Leu Leu Ala Leu Ser Ala Leu Phe Ser 
225                 230                 235                 240 


Gly Leu Arg Leu Ser Leu Leu Ser Leu Asp Pro Val Glu Leu Arg Val 
                245                 250                 255     


Leu Arg Asn Ser Gly Ser Ala Ala Glu Gln Glu Gln Ala Arg Arg Val 
            260                 265                 270         


Gln Ala Val Arg Gly Arg Gly Thr His Leu Leu Cys Thr Leu Leu Leu 
        275                 280                 285             


Gly Gln Ala Gly Ala Asn Ala Ala Leu Ala Gly Trp Leu Tyr Thr Ser 
    290                 295                 300                 


Leu Pro Pro Gly Phe Gly Gly Thr Gly Glu Asp Tyr Ser Glu Glu Gly 
305                 310                 315                 320 


Ile His Phe Pro Trp Leu Pro Ala Leu Val Cys Thr Gly Ala Val Phe 
                325                 330                 335     


Leu Gly Ala Glu Ile Cys Pro Tyr Ser Val Cys Ser Arg His Gly Leu 
            340                 345                 350         


Ala Ile Ala Ser His Ser Val Cys Leu Thr Arg Leu Leu Met Ala Ala 
        355                 360                 365             


Ala Phe Pro Val Cys Tyr Pro Leu Gly Arg Leu Leu Asp Trp Ala Leu 
    370                 375                 380                 


Arg Gln Glu Ile Ser Thr Phe Tyr Thr Arg Glu Lys Leu Leu Glu Thr 
385                 390                 395                 400 


Leu Arg Ala Ala Asp Pro Tyr Ser Asp Leu Val Lys Glu Glu Leu Asn 
                405                 410                 415     


Ile Ile Gln Gly Ala Leu Glu Leu Arg Thr Lys Val Val Glu Glu Val 
            420                 425                 430         


Leu Thr Pro Leu Gly Asp Cys Phe Met Leu Arg Ser Asp Ala Val Leu 
        435                 440                 445             


Asp Phe Ala Thr Val Ser Glu Ile Leu Arg Ser Gly Tyr Thr Arg Ile 
    450                 455                 460                 


Pro Val Tyr Glu Gly Asp Gln Arg His Asn Ile Val Asp Ile Leu Phe 
465                 470                 475                 480 


Val Lys Asp Leu Ala Phe Val Asp Pro Asp Asp Cys Thr Pro Leu Leu 
                485                 490                 495     


Thr Val Thr Arg Phe Tyr Asn Arg Pro Leu His Cys Val Phe Asn Asp 
            500                 505                 510         


Thr Arg Leu Asp Thr Val Leu Glu Glu Phe Lys Lys Gly Lys Ser His 
        515                 520                 525             


Leu Ala Ile Val Gln Arg Val Asn Asn Glu Gly Glu Gly Asp Pro Phe 
    530                 535                 540                 


Tyr Glu Val Met Gly Ile Val Thr Leu Glu Asp Ile Ile Glu Glu Ile 
545                 550                 555                 560 


Ile Lys Ser Glu Ile Leu Asp Glu Thr Asp Leu Tyr Thr Asp Asn Arg 
                565                 570                 575     


Lys Lys Gln Arg Val Pro Gln Arg Glu Arg Lys Arg His Asp Phe Ser 
            580                 585                 590         


Leu Phe Lys Leu Ser Asp Thr Glu Met Arg Val Lys Ile Ser Pro Gln 
        595                 600                 605             


Leu Leu Leu Ala Thr His Arg Phe Met Ala Thr Glu Val Glu Pro Phe 
    610                 615                 620                 


Lys Ser Leu Tyr Leu Ser Glu Lys Ile Leu Leu Arg Leu Leu Lys His 
625                 630                 635                 640 


Pro Asn Val Ile Gln Glu Leu Lys Phe Asp Glu Lys Asn Lys Lys Ala 
                645                 650                 655     


Pro Glu His Tyr Leu Tyr Gln Arg Asn Arg Pro Val Asp Tyr Phe Val 
            660                 665                 670         


Leu Leu Leu Gln Gly Lys Val Glu Val Glu Val Gly Lys Glu Gly Leu 
        675                 680                 685             


Arg Phe Glu Asn Gly Ala Phe Thr Tyr Tyr Gly Val Pro Ala Ile Met 
    690                 695                 700                 


Thr Thr Ala Cys Ser Asp Asn Asp Val Arg Lys Val Gly Ser Leu Ala 
705                 710                 715                 720 


Gly Ser Ser Val Phe Leu Asn Arg Ser Pro Ser Arg Cys Ser Gly Leu 
                725                 730                 735     


Asn Arg Ser Glu Ser Pro Asn Arg Glu Arg Ser Asp Phe Gly Gly Ser 
            740                 745                 750         


Asn Thr Gln Leu Tyr Ser Ser Ser Asn Asn Leu Tyr Met Pro Asp Tyr 
        755                 760                 765             


Ser Val His Ile Leu Ser Asp Val Gln Phe Val Lys Ile Thr Arg Gln 
    770                 775                 780                 


Gln Tyr Gln Asn Ala Leu Thr Ala Cys His Met Asp Ser Ser Pro Gln 
785                 790                 795                 800 


Ser Pro Asp Met Glu Ala Phe Thr Asp Gly Asp Ser Thr Lys Ala Pro 
                805                 810                 815     


Thr Thr Arg Gly Thr Pro Gln Thr Pro Lys Asp Asp Pro Ala Ile Thr 
            820                 825                 830         


Leu Leu Asn Asn Arg Asn Ser Leu Pro Cys Ser Arg Ser Asp Gly Leu 
        835                 840                 845             


Arg Ser Pro Ser Glu Val Val Tyr Leu Arg Met Glu Glu Leu Ala Phe 
    850                 855                 860                 


Thr Gln Glu Glu Met Thr Asp Phe Glu Glu His Ser Thr Gln Gln Leu 
865                 870                 875                 880 


Thr Leu Ser Pro Ala Ala Val Pro Thr Arg Ala Ala Ser Asp Ser Glu 
                885                 890                 895     


Cys Cys Asn Ile Asn Leu Asp Thr Glu Thr Ser Pro Cys Ser Ser Asp 
            900                 905                 910         


Phe Glu Glu Asn Val Gly Lys Lys Leu Leu Arg Thr Leu Ser Gly Gln 
        915                 920                 925             


Lys Arg Lys Arg Ser Pro Glu Gly Glu Arg Thr Ser Glu Asp Asn Ser 
    930                 935                 940                 


Asn Leu Thr Pro Leu Ile Thr 
945                 950     


<210>  714
<211>  586
<212>  PRT
<213>  Homo sapiens

<400>  714

Met Ala Ala Ala Phe Pro Val Cys Tyr Pro Leu Gly Arg Leu Leu Asp 
1               5                   10                  15      


Trp Ala Leu Arg Gln Glu Ile Ser Thr Phe Tyr Thr Arg Glu Lys Leu 
            20                  25                  30          


Leu Glu Thr Leu Arg Ala Ala Asp Pro Tyr Ser Asp Leu Val Lys Glu 
        35                  40                  45              


Glu Leu Asn Ile Ile Gln Gly Ala Leu Glu Leu Arg Thr Lys Val Val 
    50                  55                  60                  


Glu Glu Val Leu Thr Pro Leu Gly Asp Cys Phe Met Leu Arg Ser Asp 
65                  70                  75                  80  


Ala Val Leu Asp Phe Ala Thr Val Ser Glu Ile Leu Arg Ser Gly Tyr 
                85                  90                  95      


Thr Arg Ile Pro Val Tyr Glu Gly Asp Gln Arg His Asn Ile Val Asp 
            100                 105                 110         


Ile Leu Phe Val Lys Asp Leu Ala Phe Val Asp Pro Asp Asp Cys Thr 
        115                 120                 125             


Pro Leu Leu Thr Val Thr Arg Phe Tyr Asn Arg Pro Leu His Cys Val 
    130                 135                 140                 


Phe Asn Asp Thr Arg Leu Asp Thr Val Leu Glu Glu Phe Lys Lys Gly 
145                 150                 155                 160 


Lys Ser His Leu Ala Ile Val Gln Arg Val Asn Asn Glu Gly Glu Gly 
                165                 170                 175     


Asp Pro Phe Tyr Glu Val Met Gly Ile Val Thr Leu Glu Asp Ile Ile 
            180                 185                 190         


Glu Glu Ile Ile Lys Ser Glu Ile Leu Asp Glu Thr Asp Leu Tyr Thr 
        195                 200                 205             


Asp Asn Arg Lys Lys Gln Arg Val Pro Gln Arg Glu Arg Lys Arg His 
    210                 215                 220                 


Asp Phe Ser Leu Phe Lys Leu Ser Asp Thr Glu Met Arg Val Lys Ile 
225                 230                 235                 240 


Ser Pro Gln Leu Leu Leu Ala Thr His Arg Phe Met Ala Thr Glu Val 
                245                 250                 255     


Glu Pro Phe Lys Ser Leu Tyr Leu Ser Glu Lys Ile Leu Leu Arg Leu 
            260                 265                 270         


Leu Lys His Pro Asn Val Ile Gln Glu Leu Lys Phe Asp Glu Lys Asn 
        275                 280                 285             


Lys Lys Ala Pro Glu His Tyr Leu Tyr Gln Arg Asn Arg Pro Val Asp 
    290                 295                 300                 


Tyr Phe Val Leu Leu Leu Gln Gly Lys Val Glu Val Glu Val Gly Lys 
305                 310                 315                 320 


Glu Gly Leu Arg Phe Glu Asn Gly Ala Phe Thr Tyr Tyr Gly Val Pro 
                325                 330                 335     


Ala Ile Met Thr Thr Ala Cys Ser Asp Asn Asp Val Arg Lys Val Gly 
            340                 345                 350         


Ser Leu Ala Gly Ser Ser Val Phe Leu Asn Arg Ser Pro Ser Arg Cys 
        355                 360                 365             


Ser Gly Leu Asn Arg Ser Glu Ser Pro Asn Arg Glu Arg Ser Asp Phe 
    370                 375                 380                 


Gly Gly Ser Asn Thr Gln Leu Tyr Ser Ser Ser Asn Asn Leu Tyr Met 
385                 390                 395                 400 


Pro Asp Tyr Ser Val His Ile Leu Ser Asp Val Gln Phe Val Lys Ile 
                405                 410                 415     


Thr Arg Gln Gln Tyr Gln Asn Ala Leu Thr Ala Cys His Met Asp Ser 
            420                 425                 430         


Ser Pro Gln Ser Pro Asp Met Glu Ala Phe Thr Asp Gly Asp Ser Thr 
        435                 440                 445             


Lys Ala Pro Thr Thr Arg Gly Thr Pro Gln Thr Pro Lys Asp Asp Pro 
    450                 455                 460                 


Ala Ile Thr Leu Leu Asn Asn Arg Asn Ser Leu Pro Cys Ser Arg Ser 
465                 470                 475                 480 


Asp Gly Leu Arg Ser Pro Ser Glu Val Val Tyr Leu Arg Met Glu Glu 
                485                 490                 495     


Leu Ala Phe Thr Gln Glu Glu Met Thr Asp Phe Glu Glu His Ser Thr 
            500                 505                 510         


Gln Gln Leu Thr Leu Ser Pro Ala Ala Val Pro Thr Arg Ala Ala Ser 
        515                 520                 525             


Asp Ser Glu Cys Cys Asn Ile Asn Leu Asp Thr Glu Thr Ser Pro Cys 
    530                 535                 540                 


Ser Ser Asp Phe Glu Glu Asn Val Gly Lys Lys Leu Leu Arg Thr Leu 
545                 550                 555                 560 


Ser Gly Gln Lys Arg Lys Arg Ser Pro Glu Gly Glu Arg Thr Ser Glu 
                565                 570                 575     


Asp Asn Ser Asn Leu Thr Pro Leu Ile Thr 
            580                 585     


<210>  715
<211>  2415
<212>  DNA
<213>  Homo sapiens

<400>  715
cccgcggctg ccgccgccat ttcgggcgct gctgtgaagc tgaaaccgga gccggtccgc       60

tgggcggcgg gcgccggggg ccggaggggc gcgcgcggcg gcggcacccc agcgtttagg      120

cgcggaggca gccatggcgg gcaacttcga ctcggaggag cggagtagct ggtactgggg      180

gaggttgagt cggcaggagg cggtggcgct gctgcagggc cagcggcacg gggtgttcct      240

ggtgcgggac tcgagcacca gccccgggga ctatgtgctc agcgtctcag agaactcgcg      300

cgtctcccac tacatcatca acagcagcgg cccgcgcccg ccggtgccac cgtcgcccgc      360

ccagcctccg cccggggtga gcccctccag actccgaata ggagatcaag agtttgattc      420

attgcctgct ttactggaat tctacaaaat acactatttg gacactacaa cgttgataga      480

accagtttcc agatccaggc agggtagtgg agtgattctc aggcaggagg aggcggagta      540

tgtgcgagcc ctctttgact ttaatgggaa tgatgaggaa gatcttccct ttaagaaagg      600

agacatcttg agaatccggg acaagcctga agagcagtgg tggaatgcgg aggacagcga      660

aggcaagaga gggatgattc cagtccctta cgtcgagaag tatagacctg cctccgcctc      720

agtatcggct ctgattggag gtaaccagga gggttcccac ccacagccac tgggtgggcc      780

ggagcctggg ccctatgccc aacccagcgt caacactccg ctccctaacc tccagaatgg      840

gcccatatat gccagggtta tccagaagcg agtccccaat gcctacgaca agacagcctt      900

ggctttggag gtcggtgagc tggtaaaggt tacgaagatt aatgtgagtg gtcagtggga      960

aggggagtgt aatggcaaac gaggtcactt cccattcaca catgtccgtc tgctggatca     1020

acagaatccc gatgaggact tcagctgagt atagttcaac agttttgctg acagatggga     1080

acaatctttt tttttttttt ccaactgcca tctatacaat tttcttacag atgtcaaaag     1140

cagtctagtt tatataagca ttctgttacc tgtgatattt tttagactga actgctccat     1200

tcctagtctt aattaccata ttcagggtac gaactggagg gcttgtgtgt tagcttctga     1260

attggcaatt ggaggcggta gtggtcgtgc ctgtgtgtat cagaagggat aggtatcttg     1320

cctcctttct ctcaggcagt gcaaatcacc ctgtggaaaa ccgatggaca ggaaggagtg     1380

ttacacactg cttaccctga tttattcagt ggttttgttt tcattctgga accatactat     1440

caaatggcga cagactgttc cgttccaccc ccgtgaagta atcatgcacc gtgtgaatag     1500

tatcaagcag gattgctttc attgtatgga gcatgaccag cgtgtgactc attctgacat     1560

ttcagatcct aagaattcta agaacactac tagaagcatt tgttccctcc tagtcaatgc     1620

ttcatacttt ttcttgggat tcttttagcc cttgacattc ttgtccccca aacctgtaag     1680

taggtgaatt cctaagataa gtgtgtattt tcattccagg tgaaaagcag gatgtaccga     1740

gcactttatt cagtgcatag ctttaagcca gtgttggatt cactaagtgg acagccagtc     1800

tcccagctct ctgccttccc caaaagggtc gtagtaggtc acccttctac agcagctaac     1860

tagagtccta actaatggga tccagcaggg ccatttctcc agagggccag tatcctatta     1920

ggagactctt ggaattctta ggttctactc aagagtggaa ggaccaatca cctctgatat     1980

tctgtggaag gttttggggt caaattctgc cctctgcatt ctgtgcaact tgtataaaag     2040

tcaagttagt attacatgaa tttggggtag ggttagtgct ttgaaaaaat gttgaaccgg     2100

ctgggcgcgg tggctcacgt ctgtaatccc agcactttgg gaggccgagg cgggtggatc     2160

atgaggtcag gagttcgaga ccagcctggc caacatagtg aaaccccatc tctgctaaag     2220

atataaaaaa ttagcccggc gtggtggtgc acgcctgtaa tcccagctac tcgggaggct     2280

gaggcaggag aattgcttca acctgggagg tggaggctgc agtgagccga gatcgcacca     2340

ctgcgttcca gcctgagcga cagggcaaga ctcagtctca aaaaaaaaaa aaaggaaaaa     2400

aaaaagaaaa aaaaa                                                      2415


<210>  716
<211>  304
<212>  PRT
<213>  Homo sapiens

<400>  716

Met Ala Gly Asn Phe Asp Ser Glu Glu Arg Ser Ser Trp Tyr Trp Gly 
1               5                   10                  15      


Arg Leu Ser Arg Gln Glu Ala Val Ala Leu Leu Gln Gly Gln Arg His 
            20                  25                  30          


Gly Val Phe Leu Val Arg Asp Ser Ser Thr Ser Pro Gly Asp Tyr Val 
        35                  40                  45              


Leu Ser Val Ser Glu Asn Ser Arg Val Ser His Tyr Ile Ile Asn Ser 
    50                  55                  60                  


Ser Gly Pro Arg Pro Pro Val Pro Pro Ser Pro Ala Gln Pro Pro Pro 
65                  70                  75                  80  


Gly Val Ser Pro Ser Arg Leu Arg Ile Gly Asp Gln Glu Phe Asp Ser 
                85                  90                  95      


Leu Pro Ala Leu Leu Glu Phe Tyr Lys Ile His Tyr Leu Asp Thr Thr 
            100                 105                 110         


Thr Leu Ile Glu Pro Val Ser Arg Ser Arg Gln Gly Ser Gly Val Ile 
        115                 120                 125             


Leu Arg Gln Glu Glu Ala Glu Tyr Val Arg Ala Leu Phe Asp Phe Asn 
    130                 135                 140                 


Gly Asn Asp Glu Glu Asp Leu Pro Phe Lys Lys Gly Asp Ile Leu Arg 
145                 150                 155                 160 


Ile Arg Asp Lys Pro Glu Glu Gln Trp Trp Asn Ala Glu Asp Ser Glu 
                165                 170                 175     


Gly Lys Arg Gly Met Ile Pro Val Pro Tyr Val Glu Lys Tyr Arg Pro 
            180                 185                 190         


Ala Ser Ala Ser Val Ser Ala Leu Ile Gly Gly Asn Gln Glu Gly Ser 
        195                 200                 205             


His Pro Gln Pro Leu Gly Gly Pro Glu Pro Gly Pro Tyr Ala Gln Pro 
    210                 215                 220                 


Ser Val Asn Thr Pro Leu Pro Asn Leu Gln Asn Gly Pro Ile Tyr Ala 
225                 230                 235                 240 


Arg Val Ile Gln Lys Arg Val Pro Asn Ala Tyr Asp Lys Thr Ala Leu 
                245                 250                 255     


Ala Leu Glu Val Gly Glu Leu Val Lys Val Thr Lys Ile Asn Val Ser 
            260                 265                 270         


Gly Gln Trp Glu Gly Glu Cys Asn Gly Lys Arg Gly His Phe Pro Phe 
        275                 280                 285             


Thr His Val Arg Leu Leu Asp Gln Gln Asn Pro Asp Glu Asp Phe Ser 
    290                 295                 300                 


<210>  717
<211>  304
<212>  PRT
<213>  Homo sapiens

<400>  717

Met Ala Gly Asn Phe Asp Ser Glu Glu Arg Ser Ser Trp Tyr Trp Gly 
1               5                   10                  15      


Arg Leu Ser Arg Gln Glu Ala Val Ala Leu Leu Gln Gly Gln Arg His 
            20                  25                  30          


Gly Val Phe Leu Val Arg Asp Ser Ser Thr Ser Pro Gly Asp Tyr Val 
        35                  40                  45              


Leu Ser Val Ser Glu Asn Ser Arg Val Ser His Tyr Ile Ile Asn Ser 
    50                  55                  60                  


Ser Gly Pro Arg Pro Pro Val Pro Pro Ser Pro Ala Gln Pro Pro Pro 
65                  70                  75                  80  


Gly Val Ser Pro Ser Arg Leu Arg Ile Gly Asp Gln Glu Phe Asp Ser 
                85                  90                  95      


Leu Pro Ala Leu Leu Glu Phe Tyr Lys Ile His Tyr Leu Asp Thr Thr 
            100                 105                 110         


Thr Leu Ile Glu Pro Val Ser Arg Ser Arg Gln Gly Ser Gly Val Ile 
        115                 120                 125             


Leu Arg Gln Glu Glu Ala Glu Tyr Val Arg Ala Leu Phe Asp Phe Asn 
    130                 135                 140                 


Gly Asn Asp Glu Glu Asp Leu Pro Phe Lys Lys Gly Asp Ile Leu Arg 
145                 150                 155                 160 


Ile Arg Asp Lys Pro Glu Glu Gln Trp Trp Asn Ala Glu Asp Ser Glu 
                165                 170                 175     


Gly Lys Arg Gly Met Ile Pro Val Pro Tyr Val Glu Lys Tyr Arg Pro 
            180                 185                 190         


Ala Ser Ala Ser Val Ser Ala Leu Ile Gly Gly Asn Gln Glu Gly Ser 
        195                 200                 205             


His Pro Gln Pro Leu Gly Gly Pro Glu Pro Gly Pro Tyr Ala Gln Pro 
    210                 215                 220                 


Ser Val Asn Thr Pro Leu Pro Asn Leu Gln Asn Gly Pro Ile Tyr Ala 
225                 230                 235                 240 


Arg Val Ile Gln Lys Arg Val Pro Asn Ala Tyr Asp Lys Thr Ala Leu 
                245                 250                 255     


Ala Leu Glu Val Gly Glu Leu Val Lys Val Thr Lys Ile Asn Val Ser 
            260                 265                 270         


Gly Gln Trp Glu Gly Glu Cys Asn Gly Lys Arg Gly His Phe Pro Phe 
        275                 280                 285             


Thr His Val Arg Leu Leu Asp Gln Gln Asn Pro Asp Glu Asp Phe Ser 
    290                 295                 300                 


<210>  718
<211>  1110
<212>  DNA
<213>  Homo sapiens

<400>  718
gacagagccc gggccacgga gctccttgcc agctctcctc ctcgcacagc cgctcgaacc       60

gcctgctgag ccccatggcc cgcgccacgc tctccgccgc ccccagcaat ccccggctcc      120

tgcgggtggc gctgctgctc ctgctcctgg tggccgccag ccggcgcgca gcaggagcgc      180

ccctggccac tgaactgcgc tgccagtgct tgcagaccct gcagggaatt cacctcaaga      240

acatccaaag tgtgaaggtg aagtcccccg gaccccactg cgcccaaacc gaagtcatag      300

ccacactcaa gaatgggcag aaagcttgtc tcaaccccgc atcgcccatg gttaagaaaa      360

tcatcgaaaa gatgctgaaa aatggcaaat ccaactgacc agaaggaagg aggaagctta      420

ttggtggctg ttcctgaagg aggccctgcc ttacaggaac agaagaggaa agagagacac      480

agctgcagag gccacctggc ttgcgcctaa tgtgtttgag catacttagg agaagtcttc      540

tatttattta tttatttatt tatttgtttg ttttagaaga ttctatgtta atattttatg      600

tgtaaaataa ggttatgatt gaatctactt gcacactctc ccattatatt tattgtttat      660

tttaggtcaa acccaagtta gttcaatcct gattcatatt taatttgaag atagaaggtt      720

tgcagatatt ctctagtcat ttgttaatat ttcttcgtga tgacatatca catgtcagcc      780

actgtgatag aggctgagga atccaagaaa atggccagta agatcaatgt gacggcaggg      840

aaatgtatgt gtgtctattt tgtaactgta aagatgaatg tcagttgtta tttattgaaa      900

tgatttcaca gtgtgtggtc aacatttctc atgttgaagc tttaagaact aaaatgttct      960

aaatatccct tggcatttta tgtctttctt gtaagatact gccttgttta atgttaatta     1020

tgcagtgttt ccctctgtgt tagagcagag aggtttcgat atttattgat gttttcacaa     1080

agaacaggaa aataaaatat ttaaaaatat                                      1110


<210>  719
<211>  107
<212>  PRT
<213>  Homo sapiens

<400>  719

Met Ala Arg Ala Thr Leu Ser Ala Ala Pro Ser Asn Pro Arg Leu Leu 
1               5                   10                  15      


Arg Val Ala Leu Leu Leu Leu Leu Leu Val Ala Ala Ser Arg Arg Ala 
            20                  25                  30          


Ala Gly Ala Pro Leu Ala Thr Glu Leu Arg Cys Gln Cys Leu Gln Thr 
        35                  40                  45              


Leu Gln Gly Ile His Leu Lys Asn Ile Gln Ser Val Lys Val Lys Ser 
    50                  55                  60                  


Pro Gly Pro His Cys Ala Gln Thr Glu Val Ile Ala Thr Leu Lys Asn 
65                  70                  75                  80  


Gly Gln Lys Ala Cys Leu Asn Pro Ala Ser Pro Met Val Lys Lys Ile 
                85                  90                  95      


Ile Glu Lys Met Leu Lys Asn Gly Lys Ser Asn 
            100                 105         


<210>  720
<211>  107
<212>  PRT
<213>  Homo sapiens

<400>  720

Met Ala Arg Ala Thr Leu Ser Ala Ala Pro Ser Asn Pro Arg Leu Leu 
1               5                   10                  15      


Arg Val Ala Leu Leu Leu Leu Leu Leu Val Ala Ala Ser Arg Arg Ala 
            20                  25                  30          


Ala Gly Ala Pro Leu Ala Thr Glu Leu Arg Cys Gln Cys Leu Gln Thr 
        35                  40                  45              


Leu Gln Gly Ile His Leu Lys Asn Ile Gln Ser Val Lys Val Lys Ser 
    50                  55                  60                  


Pro Gly Pro His Cys Ala Gln Thr Glu Val Ile Ala Thr Leu Lys Asn 
65                  70                  75                  80  


Gly Gln Lys Ala Cys Leu Asn Pro Ala Ser Pro Met Val Lys Lys Ile 
                85                  90                  95      


Ile Glu Lys Met Leu Lys Asn Gly Lys Ser Asn 
            100                 105         


<210>  721
<211>  1808
<212>  DNA
<213>  Homo sapiens

<400>  721
ataaaaagaa tggctttgca ctgagcagct cagtctactg gtctcatcag tgaaaggctt       60

gtgaaaattt ctggaaagag cattggctgg cttgttcatc tctctgtttg gtcagttgct      120

gtgtttctgc cggatcagat gagcagattg gttagtgaag gtcagtgtga gaagaagatt      180

gtttctgagc ttgagaagct tctggaggat tgaagagtat ttgaagtctg tgtcaaacat      240

ccacatcata agtggaattt tggagatatt caaagaatgc tgtcagaagg gtatctcagt      300

ggacttgagt actggaatga catccactgg agttgtgcct cttataatga gcaggtggct      360

ggggaaaagg aagaggagac aaattctgtt gctacccttt cctattcctc tgtggatgaa      420

acacaagtca gaagtctcta cgtgagctgc aaatcatctg gcaagtttat ctcttcagtg      480

cattcaagag agagccaaca tagcagaagt cagagagtca cagtgctgca gacaaacccc      540

aatcctgtgt ttgaaagccc aaacttggct gcagttgaaa tatgtagaga tgccagcaga      600

gagacctact tggttccatc ttcttgcaaa agtatttgca agaactataa tgacttacag      660

attgcagggg gccaggtgat ggccattaat tcagtgacaa cagattttcc ctctgagagc      720

agttttgaat atggcccttt gctgaagtca tctgagattc ctttacccat ggaggattcc      780

atttctactc agcccagtga ctttccccaa aaacctatcc agcggtactc atcctattgg      840

agaataacaa gcatcaaaga gaaaagcagc ttgcaaatgc agaatcctat ttctaatgca      900

gtgctgaatg agtacctgga gcagaaggtt gtggagttat ataaacagta cattatggac      960

accgtgtttc atgacagttc tcctacccag attctggcgt ctgaactcat catgacaagt     1020

gtagaccaaa tcagtcttca agtgtctaga gagaagaatc tggagacctc aaaagccaga     1080

gatatagtct ttagccgcct attgcaattg atgtcaactg aaattactga aattagcact     1140

cctagtctcc atatttctca gtatagcaat gtaaatccat agagaggatg cttccattac     1200

tgtctcgcat ttacttaaac atgaagcaac actttatcca tttattctga gaatgtgcag     1260

gaggggttag tgaaggggaa ttaagggcta gagaagtaaa gatcagctgg aagtcatgtg     1320

tgaatcatgg agaaatctca taatattaca cttgatgaag gaatatggta agaggagcca     1380

taaggaatga tttcaaagag aggtgtgtac agcaaggaag caaaaataaa aatgatcaaa     1440

aaagaaacgg ttaattcatt tgaagaaaca taggaattaa aaaagaagac agtcaaatga     1500

gatgaaacaa aaaggccaaa aggtagccgg gtgtagtggc tcacgcctgt aatcccagca     1560

tttgggaggc tgatgtgggt ggattacctg acgtcaggaa ttcgagaccg gcctggccaa     1620

tatggtgaaa ccccatctct actaaaaata caaaaaatta gctggacatg gtggtgggta     1680

cctgtaatcc cagctactag ggaggctgag gcaggagaat ctcttgaacc tgagaggcag     1740

aggttgcagt gagccgaggt cgctccattg cactccagcc tgggcaacaa gagtgagact     1800

cccgtctc                                                              1808


<210>  722
<211>  301
<212>  PRT
<213>  Homo sapiens

<400>  722

Met Leu Ser Glu Gly Tyr Leu Ser Gly Leu Glu Tyr Trp Asn Asp Ile 
1               5                   10                  15      


His Trp Ser Cys Ala Ser Tyr Asn Glu Gln Val Ala Gly Glu Lys Glu 
            20                  25                  30          


Glu Glu Thr Asn Ser Val Ala Thr Leu Ser Tyr Ser Ser Val Asp Glu 
        35                  40                  45              


Thr Gln Val Arg Ser Leu Tyr Val Ser Cys Lys Ser Ser Gly Lys Phe 
    50                  55                  60                  


Ile Ser Ser Val His Ser Arg Glu Ser Gln His Ser Arg Ser Gln Arg 
65                  70                  75                  80  


Val Thr Val Leu Gln Thr Asn Pro Asn Pro Val Phe Glu Ser Pro Asn 
                85                  90                  95      


Leu Ala Ala Val Glu Ile Cys Arg Asp Ala Ser Arg Glu Thr Tyr Leu 
            100                 105                 110         


Val Pro Ser Ser Cys Lys Ser Ile Cys Lys Asn Tyr Asn Asp Leu Gln 
        115                 120                 125             


Ile Ala Gly Gly Gln Val Met Ala Ile Asn Ser Val Thr Thr Asp Phe 
    130                 135                 140                 


Pro Ser Glu Ser Ser Phe Glu Tyr Gly Pro Leu Leu Lys Ser Ser Glu 
145                 150                 155                 160 


Ile Pro Leu Pro Met Glu Asp Ser Ile Ser Thr Gln Pro Ser Asp Phe 
                165                 170                 175     


Pro Gln Lys Pro Ile Gln Arg Tyr Ser Ser Tyr Trp Arg Ile Thr Ser 
            180                 185                 190         


Ile Lys Glu Lys Ser Ser Leu Gln Met Gln Asn Pro Ile Ser Asn Ala 
        195                 200                 205             


Val Leu Asn Glu Tyr Leu Glu Gln Lys Val Val Glu Leu Tyr Lys Gln 
    210                 215                 220                 


Tyr Ile Met Asp Thr Val Phe His Asp Ser Ser Pro Thr Gln Ile Leu 
225                 230                 235                 240 


Ala Ser Glu Leu Ile Met Thr Ser Val Asp Gln Ile Ser Leu Gln Val 
                245                 250                 255     


Ser Arg Glu Lys Asn Leu Glu Thr Ser Lys Ala Arg Asp Ile Val Phe 
            260                 265                 270         


Ser Arg Leu Leu Gln Leu Met Ser Thr Glu Ile Thr Glu Ile Ser Thr 
        275                 280                 285             


Pro Ser Leu His Ile Ser Gln Tyr Ser Asn Val Asn Pro 
    290                 295                 300     


<210>  723
<211>  301
<212>  PRT
<213>  Homo sapiens

<400>  723

Met Leu Ser Glu Gly Tyr Leu Ser Gly Leu Glu Tyr Trp Asn Asp Ile 
1               5                   10                  15      


His Trp Ser Cys Ala Ser Tyr Asn Glu Gln Val Ala Gly Glu Lys Glu 
            20                  25                  30          


Glu Glu Thr Asn Ser Val Ala Thr Leu Ser Tyr Ser Ser Val Asp Glu 
        35                  40                  45              


Thr Gln Val Arg Ser Leu Tyr Val Ser Cys Lys Ser Ser Gly Lys Phe 
    50                  55                  60                  


Ile Ser Ser Val His Ser Arg Glu Ser Gln His Ser Arg Ser Gln Arg 
65                  70                  75                  80  


Val Thr Val Leu Gln Thr Asn Pro Asn Pro Val Phe Glu Ser Pro Asn 
                85                  90                  95      


Leu Ala Ala Val Glu Ile Cys Arg Asp Ala Ser Arg Glu Thr Tyr Leu 
            100                 105                 110         


Val Pro Ser Ser Cys Lys Ser Ile Cys Lys Asn Tyr Asn Asp Leu Gln 
        115                 120                 125             


Ile Ala Gly Gly Gln Val Met Ala Ile Asn Ser Val Thr Thr Asp Phe 
    130                 135                 140                 


Pro Ser Glu Ser Ser Phe Glu Tyr Gly Pro Leu Leu Lys Ser Ser Glu 
145                 150                 155                 160 


Ile Pro Leu Pro Met Glu Asp Ser Ile Ser Thr Gln Pro Ser Asp Phe 
                165                 170                 175     


Pro Gln Lys Pro Ile Gln Arg Tyr Ser Ser Tyr Trp Arg Ile Thr Ser 
            180                 185                 190         


Ile Lys Glu Lys Ser Ser Leu Gln Met Gln Asn Pro Ile Ser Asn Ala 
        195                 200                 205             


Val Leu Asn Glu Tyr Leu Glu Gln Lys Val Val Glu Leu Tyr Lys Gln 
    210                 215                 220                 


Tyr Ile Met Asp Thr Val Phe His Asp Ser Ser Pro Thr Gln Ile Leu 
225                 230                 235                 240 


Ala Ser Glu Leu Ile Met Thr Ser Val Asp Gln Ile Ser Leu Gln Val 
                245                 250                 255     


Ser Arg Glu Lys Asn Leu Glu Thr Ser Lys Ala Arg Asp Ile Val Phe 
            260                 265                 270         


Ser Arg Leu Leu Gln Leu Met Ser Thr Glu Ile Thr Glu Ile Ser Thr 
        275                 280                 285             


Pro Ser Leu His Ile Ser Gln Tyr Ser Asn Val Asn Pro 
    290                 295                 300     


<210>  724
<211>  2602
<212>  DNA
<213>  Homo sapiens

<400>  724
ctcaccctga aggtgacagt tccttggaac cttccctgat ccttgtgatc ccaggctcca       60

agagtccacc cttcccagct cagctcagta cctcagccac ctccaagatc cctacactga      120

tcatgctttt cccaatctcc atgtcggcca cggagtttct tctggcctct gtcatcttct      180

gtctggtatt ctgggtaatc agggcctcaa gacctcaggt ccccaaaggc ctgaagaatc      240

caccagggcc atggggctgg cctctgattg ggcacatgct gaccctggga aagaacccgc      300

acctggcact gtcaaggatg agccagcagt atggggacgt gctgcagatc cgaattggct      360

ccacacccgt ggtggtgctg agcggcctgg acaccatccg gcaggccctg gtgcggcagg      420

gcgatgattt caagggccgg cccgacctct acaccttcac cctcatcagt aatggtcaga      480

gcatgtcctt cagcccagac tctggaccag tgtgggctgc ccgccggcgc ctggcccaga      540

atggcctgaa aagtttctcc attgcctctg acccagcctc ctcaacctcc tgctacctgg      600

aagagcatgt gagcaaggag gctgaggtcc tgataagcac gttgcaggag ctgatggcag      660

ggcctgggca ctttaacccc tacaggtatg tggtggtatc agtgaccaat gtcatctgtg      720

ccatttgctt tggccggcgc tatgaccaca accaccaaga actgcttagc ctagtcaacc      780

tgaataataa tttcggggag gtggttggct ctggaaaccc agctgacttc atccctattc      840

ttcgctacct acccaaccct tccctgaatg ccttcaagga cctgaatgag aagttctaca      900

gcttcatgca gaagatggtc aaggagcact acaaaacctt tgagaagggc cacatccggg      960

acatcacaga cagcctgatt gagcactgtc aggagaagca gctggatgag aacgccaatg     1020

tccagctgtc agatgagaag atcattaaca tcgtcttgga cctctttgga gctgggtttg     1080

acacagtcac aactgctatc tcctggagcc tcatgtattt ggtgatgaac cccagggtac     1140

agagaaagat ccaagaggag ctagacacag tgattggcag gtcacggcgg ccccggctct     1200

ctgacagatc ccatctgccc tatatggagg ccttcatcct ggagaccttc cgacactctt     1260

ccttcgtccc cttcaccatc ccccacagca caacaagaga cacaagtttg aaaggctttt     1320

acatccccaa ggggcgttgt gtctttgtaa accagtggca gatcaaccat gaccagaagc     1380

tatgggtcaa cccatctgag ttcctacctg aacggtttct cacccctgat ggtgctatcg     1440

acaaggtgtt aagtgagaag gtgattatct ttggcatggg caagcggaag tgtatcggtg     1500

agaccattgc ccgctgggag gtctttctct tcctggctat cctgctgcaa cgggtggaat     1560

tcagcgtgcc actgggcgtg aaggtggaca tgacccccat ctatgggcta accatgaagc     1620

atgcctgctg tgagcacttc caaatgcagc tgcgctctta ggtgcttgag agccctgagg     1680

cctagactct gtctacctgg tctggttggg cagccagacc agcaggctgg cctatgtggt     1740

ctaagattca gcctgaaact catagacact gatctggctg cagttttgct atctgggctg     1800

tgggcaagcc taagggatcc tgcctgcccc taccctggac ttgcctctgc acaccctcca     1860

gagacaacag gtaaaacagg gccacataga tgctgatgga gccttcccaa gttgtgcttg     1920

agccaggagg cctgctaggg ttaggaggtc cttaggcctc tgagaagctc tgaagaactc     1980

tctggaagcc cctgggccca gtacctagct ggctctgtga gggtgctgac tggcttcagc     2040

aagttagaac tagccaaacc aggaccctgt ccaatctttg acaattggga gctgccaaga     2100

gtgaagggaa gagacagccc aggatactgg cacagaggta gtctcactgc ttgaactagg     2160

ctgagcaatc tgaccctatg ggtctaggac acagttcctg ggaacatcac attcctctgc     2220

ccttcctgca ggcaggaaca aacagggctg ccttctggcc ttgtaagacc cttattgctg     2280

tcctggaggg gctggggact tgtgtctgcg gggatccaga gcgcacaggg agtgcacata     2340

tccaggcacc aggactaggg ctggagtgag gggggggtat ttcaattacc ttctattggt     2400

ctcccttctc tacactcttg taataaaatg tctattttta atgtttgtac acaacaatcc     2460

ttctattcta gcctgcattg agcttgcatg cttgcataag agcttaagaa ccattgattt     2520

aatgtaatag ggaaaattct aacccaggta tccaaaaatg tgtaagaaca actacctgag     2580

ctaaataaag atattgttca ga                                              2602


<210>  725
<211>  512
<212>  PRT
<213>  Homo sapiens

<400>  725

Met Leu Phe Pro Ile Ser Met Ser Ala Thr Glu Phe Leu Leu Ala Ser 
1               5                   10                  15      


Val Ile Phe Cys Leu Val Phe Trp Val Ile Arg Ala Ser Arg Pro Gln 
            20                  25                  30          


Val Pro Lys Gly Leu Lys Asn Pro Pro Gly Pro Trp Gly Trp Pro Leu 
        35                  40                  45              


Ile Gly His Met Leu Thr Leu Gly Lys Asn Pro His Leu Ala Leu Ser 
    50                  55                  60                  


Arg Met Ser Gln Gln Tyr Gly Asp Val Leu Gln Ile Arg Ile Gly Ser 
65                  70                  75                  80  


Thr Pro Val Val Val Leu Ser Gly Leu Asp Thr Ile Arg Gln Ala Leu 
                85                  90                  95      


Val Arg Gln Gly Asp Asp Phe Lys Gly Arg Pro Asp Leu Tyr Thr Phe 
            100                 105                 110         


Thr Leu Ile Ser Asn Gly Gln Ser Met Ser Phe Ser Pro Asp Ser Gly 
        115                 120                 125             


Pro Val Trp Ala Ala Arg Arg Arg Leu Ala Gln Asn Gly Leu Lys Ser 
    130                 135                 140                 


Phe Ser Ile Ala Ser Asp Pro Ala Ser Ser Thr Ser Cys Tyr Leu Glu 
145                 150                 155                 160 


Glu His Val Ser Lys Glu Ala Glu Val Leu Ile Ser Thr Leu Gln Glu 
                165                 170                 175     


Leu Met Ala Gly Pro Gly His Phe Asn Pro Tyr Arg Tyr Val Val Val 
            180                 185                 190         


Ser Val Thr Asn Val Ile Cys Ala Ile Cys Phe Gly Arg Arg Tyr Asp 
        195                 200                 205             


His Asn His Gln Glu Leu Leu Ser Leu Val Asn Leu Asn Asn Asn Phe 
    210                 215                 220                 


Gly Glu Val Val Gly Ser Gly Asn Pro Ala Asp Phe Ile Pro Ile Leu 
225                 230                 235                 240 


Arg Tyr Leu Pro Asn Pro Ser Leu Asn Ala Phe Lys Asp Leu Asn Glu 
                245                 250                 255     


Lys Phe Tyr Ser Phe Met Gln Lys Met Val Lys Glu His Tyr Lys Thr 
            260                 265                 270         


Phe Glu Lys Gly His Ile Arg Asp Ile Thr Asp Ser Leu Ile Glu His 
        275                 280                 285             


Cys Gln Glu Lys Gln Leu Asp Glu Asn Ala Asn Val Gln Leu Ser Asp 
    290                 295                 300                 


Glu Lys Ile Ile Asn Ile Val Leu Asp Leu Phe Gly Ala Gly Phe Asp 
305                 310                 315                 320 


Thr Val Thr Thr Ala Ile Ser Trp Ser Leu Met Tyr Leu Val Met Asn 
                325                 330                 335     


Pro Arg Val Gln Arg Lys Ile Gln Glu Glu Leu Asp Thr Val Ile Gly 
            340                 345                 350         


Arg Ser Arg Arg Pro Arg Leu Ser Asp Arg Ser His Leu Pro Tyr Met 
        355                 360                 365             


Glu Ala Phe Ile Leu Glu Thr Phe Arg His Ser Ser Phe Val Pro Phe 
    370                 375                 380                 


Thr Ile Pro His Ser Thr Thr Arg Asp Thr Ser Leu Lys Gly Phe Tyr 
385                 390                 395                 400 


Ile Pro Lys Gly Arg Cys Val Phe Val Asn Gln Trp Gln Ile Asn His 
                405                 410                 415     


Asp Gln Lys Leu Trp Val Asn Pro Ser Glu Phe Leu Pro Glu Arg Phe 
            420                 425                 430         


Leu Thr Pro Asp Gly Ala Ile Asp Lys Val Leu Ser Glu Lys Val Ile 
        435                 440                 445             


Ile Phe Gly Met Gly Lys Arg Lys Cys Ile Gly Glu Thr Ile Ala Arg 
    450                 455                 460                 


Trp Glu Val Phe Leu Phe Leu Ala Ile Leu Leu Gln Arg Val Glu Phe 
465                 470                 475                 480 


Ser Val Pro Leu Gly Val Lys Val Asp Met Thr Pro Ile Tyr Gly Leu 
                485                 490                 495     


Thr Met Lys His Ala Cys Cys Glu His Phe Gln Met Gln Leu Arg Ser 
            500                 505                 510         


<210>  726
<211>  512
<212>  PRT
<213>  Homo sapiens

<400>  726

Met Leu Phe Pro Ile Ser Met Ser Ala Thr Glu Phe Leu Leu Ala Ser 
1               5                   10                  15      


Val Ile Phe Cys Leu Val Phe Trp Val Ile Arg Ala Ser Arg Pro Gln 
            20                  25                  30          


Val Pro Lys Gly Leu Lys Asn Pro Pro Gly Pro Trp Gly Trp Pro Leu 
        35                  40                  45              


Ile Gly His Met Leu Thr Leu Gly Lys Asn Pro His Leu Ala Leu Ser 
    50                  55                  60                  


Arg Met Ser Gln Gln Tyr Gly Asp Val Leu Gln Ile Arg Ile Gly Ser 
65                  70                  75                  80  


Thr Pro Val Val Val Leu Ser Gly Leu Asp Thr Ile Arg Gln Ala Leu 
                85                  90                  95      


Val Arg Gln Gly Asp Asp Phe Lys Gly Arg Pro Asp Leu Tyr Thr Phe 
            100                 105                 110         


Thr Leu Ile Ser Asn Gly Gln Ser Met Ser Phe Ser Pro Asp Ser Gly 
        115                 120                 125             


Pro Val Trp Ala Ala Arg Arg Arg Leu Ala Gln Asn Gly Leu Lys Ser 
    130                 135                 140                 


Phe Ser Ile Ala Ser Asp Pro Ala Ser Ser Thr Ser Cys Tyr Leu Glu 
145                 150                 155                 160 


Glu His Val Ser Lys Glu Ala Glu Val Leu Ile Ser Thr Leu Gln Glu 
                165                 170                 175     


Leu Met Ala Gly Pro Gly His Phe Asn Pro Tyr Arg Tyr Val Val Val 
            180                 185                 190         


Ser Val Thr Asn Val Ile Cys Ala Ile Cys Phe Gly Arg Arg Tyr Asp 
        195                 200                 205             


His Asn His Gln Glu Leu Leu Ser Leu Val Asn Leu Asn Asn Asn Phe 
    210                 215                 220                 


Gly Glu Val Val Gly Ser Gly Asn Pro Ala Asp Phe Ile Pro Ile Leu 
225                 230                 235                 240 


Arg Tyr Leu Pro Asn Pro Ser Leu Asn Ala Phe Lys Asp Leu Asn Glu 
                245                 250                 255     


Lys Phe Tyr Ser Phe Met Gln Lys Met Val Lys Glu His Tyr Lys Thr 
            260                 265                 270         


Phe Glu Lys Gly His Ile Arg Asp Ile Thr Asp Ser Leu Ile Glu His 
        275                 280                 285             


Cys Gln Glu Lys Gln Leu Asp Glu Asn Ala Asn Val Gln Leu Ser Asp 
    290                 295                 300                 


Glu Lys Ile Ile Asn Ile Val Leu Asp Leu Phe Gly Ala Gly Phe Asp 
305                 310                 315                 320 


Thr Val Thr Thr Ala Ile Ser Trp Ser Leu Met Tyr Leu Val Met Asn 
                325                 330                 335     


Pro Arg Val Gln Arg Lys Ile Gln Glu Glu Leu Asp Thr Val Ile Gly 
            340                 345                 350         


Arg Ser Arg Arg Pro Arg Leu Ser Asp Arg Ser His Leu Pro Tyr Met 
        355                 360                 365             


Glu Ala Phe Ile Leu Glu Thr Phe Arg His Ser Ser Phe Val Pro Phe 
    370                 375                 380                 


Thr Ile Pro His Ser Thr Thr Arg Asp Thr Ser Leu Lys Gly Phe Tyr 
385                 390                 395                 400 


Ile Pro Lys Gly Arg Cys Val Phe Val Asn Gln Trp Gln Ile Asn His 
                405                 410                 415     


Asp Gln Lys Leu Trp Val Asn Pro Ser Glu Phe Leu Pro Glu Arg Phe 
            420                 425                 430         


Leu Thr Pro Asp Gly Ala Ile Asp Lys Val Leu Ser Glu Lys Val Ile 
        435                 440                 445             


Ile Phe Gly Met Gly Lys Arg Lys Cys Ile Gly Glu Thr Ile Ala Arg 
    450                 455                 460                 


Trp Glu Val Phe Leu Phe Leu Ala Ile Leu Leu Gln Arg Val Glu Phe 
465                 470                 475                 480 


Ser Val Pro Leu Gly Val Lys Val Asp Met Thr Pro Ile Tyr Gly Leu 
                485                 490                 495     


Thr Met Lys His Ala Cys Cys Glu His Phe Gln Met Gln Leu Arg Ser 
            500                 505                 510         


<210>  727
<211>  1123
<212>  DNA
<213>  Homo sapiens

<400>  727
cggaagatgg cgtaccagag cttgcgactg gagtacctgc agatcccacc ggtcagccgc       60

gcctacacca ctgcctgcgt cctcaccacc gccgccgtgc agttggaatt gatcacacct      120

tttcagttgt acttcaatcc tgaattaatc tttaaacact ttcaaatatg gagattaatc      180

accaacttct tattttttgg gccagttgga ttcaattttt tatttaacat gatttttcta      240

tatcgttact gtcgaatgct agaagaaggc tctttccgag gtcggacagc agactttgta      300

tttatgttcc tttttggtgg attcttaatg accctttttg gtctgtttgt gagcttagtt      360

ttcttggggc cagggcttta caataatggc tcgtctatgt gtggagccga agaaccccta      420

tgtccgcatg aacttcttcg gccttctcaa cttccaggcc ccctttctgc cctgggtgct      480

catgggattt tccttgttgt tggggaactc aatcattgtg gaccttttgg gtattgcagt      540

tggacacata tattttttct tggaagatgt atttcccaat caacctggtg gaataagaat      600

tctgaaaaca ccatctattt tgaaagctat ttttgataca ccagatgagg atccaaatta      660

caatccacta cctgaggaac ggccaggagg cttcgcctgg ggtgagggcc agcggcttgg      720

aggttaaagc agcagtgcca ataatgagac ccagctggga aggactcggt gatacccact      780

gggatctttt atcctttgtt gcaaaagtgt ggacactttt gacagcttgg cagattttaa      840

ctccagaagc actttatgaa atggtacact gactaatcca gaagacattt ccaacagttt      900

gccagtggtt cctcactaca ctggtactga aagtgtaatt tcttagagcc aaaaaactgg      960

agaaacaaat atcctgccac ctctaacaag tacatgagta cttgattttt atggtataag     1020

gcagagcctt ttcttcctct tcttgataga tgaggccatg gtgtaaatgg aagtttcaga     1080

gaggacaaaa taaaacggaa ttccattttt ctctcactgt aaa                       1123


<210>  728
<211>  239
<212>  PRT
<213>  Homo sapiens

<400>  728

Met Ala Tyr Gln Ser Leu Arg Leu Glu Tyr Leu Gln Ile Pro Pro Val 
1               5                   10                  15      


Ser Arg Ala Tyr Thr Thr Ala Cys Val Leu Thr Thr Ala Ala Val Gln 
            20                  25                  30          


Leu Glu Leu Ile Thr Pro Phe Gln Leu Tyr Phe Asn Pro Glu Leu Ile 
        35                  40                  45              


Phe Lys His Phe Gln Ile Trp Arg Leu Ile Thr Asn Phe Leu Phe Phe 
    50                  55                  60                  


Gly Pro Val Gly Phe Asn Phe Leu Phe Asn Met Ile Phe Leu Tyr Arg 
65                  70                  75                  80  


Tyr Cys Arg Met Leu Glu Glu Gly Ser Phe Arg Gly Arg Thr Ala Asp 
                85                  90                  95      


Phe Val Phe Met Phe Leu Phe Gly Gly Phe Leu Met Thr Leu Phe Gly 
            100                 105                 110         


Leu Phe Val Ser Leu Val Phe Leu Gly Gln Ala Phe Thr Ile Met Leu 
        115                 120                 125             


Val Tyr Val Trp Ser Arg Arg Asn Pro Tyr Val Arg Met Asn Phe Phe 
    130                 135                 140                 


Gly Leu Leu Asn Phe Gln Ala Pro Phe Leu Pro Trp Val Leu Met Gly 
145                 150                 155                 160 


Phe Ser Leu Leu Leu Gly Asn Ser Ile Ile Val Asp Leu Leu Gly Ile 
                165                 170                 175     


Ala Val Gly His Ile Tyr Phe Phe Leu Glu Asp Val Phe Pro Asn Gln 
            180                 185                 190         


Pro Gly Gly Ile Arg Ile Leu Lys Thr Pro Ser Ile Leu Lys Ala Ile 
        195                 200                 205             


Phe Asp Thr Pro Asp Glu Asp Pro Asn Tyr Asn Pro Leu Pro Glu Glu 
    210                 215                 220                 


Arg Pro Gly Gly Phe Ala Trp Gly Glu Gly Gln Arg Leu Gly Gly 
225                 230                 235                 


<210>  729
<211>  239
<212>  PRT
<213>  Homo sapiens

<400>  729

Met Ala Tyr Gln Ser Leu Arg Leu Glu Tyr Leu Gln Ile Pro Pro Val 
1               5                   10                  15      


Ser Arg Ala Tyr Thr Thr Ala Cys Val Leu Thr Thr Ala Ala Val Gln 
            20                  25                  30          


Leu Glu Leu Ile Thr Pro Phe Gln Leu Tyr Phe Asn Pro Glu Leu Ile 
        35                  40                  45              


Phe Lys His Phe Gln Ile Trp Arg Leu Ile Thr Asn Phe Leu Phe Phe 
    50                  55                  60                  


Gly Pro Val Gly Phe Asn Phe Leu Phe Asn Met Ile Phe Leu Tyr Arg 
65                  70                  75                  80  


Tyr Cys Arg Met Leu Glu Glu Gly Ser Phe Arg Gly Arg Thr Ala Asp 
                85                  90                  95      


Phe Val Phe Met Phe Leu Phe Gly Gly Phe Leu Met Thr Leu Phe Gly 
            100                 105                 110         


Leu Phe Val Ser Leu Val Phe Leu Gly Gln Ala Phe Thr Ile Met Leu 
        115                 120                 125             


Val Tyr Val Trp Ser Arg Arg Asn Pro Tyr Val Arg Met Asn Phe Phe 
    130                 135                 140                 


Gly Leu Leu Asn Phe Gln Ala Pro Phe Leu Pro Trp Val Leu Met Gly 
145                 150                 155                 160 


Phe Ser Leu Leu Leu Gly Asn Ser Ile Ile Val Asp Leu Leu Gly Ile 
                165                 170                 175     


Ala Val Gly His Ile Tyr Phe Phe Leu Glu Asp Val Phe Pro Asn Gln 
            180                 185                 190         


Pro Gly Gly Ile Arg Ile Leu Lys Thr Pro Ser Ile Leu Lys Ala Ile 
        195                 200                 205             


Phe Asp Thr Pro Asp Glu Asp Pro Asn Tyr Asn Pro Leu Pro Glu Glu 
    210                 215                 220                 


Arg Pro Gly Gly Phe Ala Trp Gly Glu Gly Gln Arg Leu Gly Gly 
225                 230                 235                 


<210>  730
<211>  5616
<212>  DNA
<213>  Homo sapiens

<400>  730
ccccggcgca gcgcggccgc agcagcctcc gccccccgca cggtgtgagc gcccgacgcg       60

gccgaggcgg ccggagtccc gagctagccc cggcggccgc cgccgcccag accggacgac      120

aggccacctc gtcggcgtcc gcccgagtcc ccgcctcgcc gccaacgcca caaccaccgc      180

gcacggcccc ctgactccgt ccagtattga tcgggagagc cggagcgagc tcttcgggga      240

gcagcgatgc gaccctccgg gacggccggg gcagcgctcc tggcgctgct ggctgcgctc      300

tgcccggcga gtcgggctct ggaggaaaag aaagtttgcc aaggcacgag taacaagctc      360

acgcagttgg gcacttttga agatcatttt ctcagcctcc agaggatgtt caataactgt      420

gaggtggtcc ttgggaattt ggaaattacc tatgtgcaga ggaattatga tctttccttc      480

ttaaagacca tccaggaggt ggctggttat gtcctcattg ccctcaacac agtggagcga      540

attcctttgg aaaacctgca gatcatcaga ggaaatatgt actacgaaaa ttcctatgcc      600

ttagcagtct tatctaacta tgatgcaaat aaaaccggac tgaaggagct gcccatgaga      660

aatttacagg aaatcctgca tggcgccgtg cggttcagca acaaccctgc cctgtgcaac      720

gtggagagca tccagtggcg ggacatagtc agcagtgact ttctcagcaa catgtcgatg      780

gacttccaga accacctggg cagctgccaa aagtgtgatc caagctgtcc caatgggagc      840

tgctggggtg caggagagga gaactgccag aaactgacca aaatcatctg tgcccagcag      900

tgctccgggc gctgccgtgg caagtccccc agtgactgct gccacaacca gtgtgctgca      960

ggctgcacag gcccccggga gagcgactgc ctggtctgcc gcaaattccg agacgaagcc     1020

acgtgcaagg acacctgccc cccactcatg ctctacaacc ccaccacgta ccagatggat     1080

gtgaaccccg agggcaaata cagctttggt gccacctgcg tgaagaagtg tccccgtaat     1140

tatgtggtga cagatcacgg ctcgtgcgtc cgagcctgtg gggccgacag ctatgagatg     1200

gaggaagacg gcgtccgcaa gtgtaagaag tgcgaagggc cttgccgcaa agtgtgtaac     1260

ggaataggta ttggtgaatt taaagactca ctctccataa atgctacgaa tattaaacac     1320

ttcaaaaact gcacctccat cagtggcgat ctccacatcc tgccggtggc atttaggggt     1380

gactccttca cacatactcc tcctctggat ccacaggaac tggatattct gaaaaccgta     1440

aaggaaatca cagggttttt gctgattcag gcttggcctg aaaacaggac ggacctccat     1500

gcctttgaga acctagaaat catacgcggc aggaccaagc aacatggtca gttttctctt     1560

gcagtcgtca gcctgaacat aacatccttg ggattacgct ccctcaagga gataagtgat     1620

ggagatgtga taatttcagg aaacaaaaat ttgtgctatg caaatacaat aaactggaaa     1680

aaactgtttg ggacctccgg tcagaaaacc aaaattataa gcaacagagg tgaaaacagc     1740

tgcaaggcca caggccaggt ctgccatgcc ttgtgctccc ccgagggctg ctggggcccg     1800

gagcccaggg actgcgtctc ttgccggaat gtcagccgag gcagggaatg cgtggacaag     1860

tgcaaccttc tggagggtga gccaagggag tttgtggaga actctgagtg catacagtgc     1920

cacccagagt gcctgcctca ggccatgaac atcacctgca caggacgggg accagacaac     1980

tgtatccagt gtgcccacta cattgacggc ccccactgcg tcaagacctg cccggcagga     2040

gtcatgggag aaaacaacac cctggtctgg aagtacgcag acgccggcca tgtgtgccac     2100

ctgtgccatc caaactgcac ctacggatgc actgggccag gtcttgaagg ctgtccaacg     2160

aatgggccta agatcccgtc catcgccact gggatggtgg gggccctcct cttgctgctg     2220

gtggtggccc tggggatcgg cctcttcatg cgaaggcgcc acatcgttcg gaagcgcacg     2280

ctgcggaggc tgctgcagga gagggagctt gtggagcctc ttacacccag tggagaagct     2340

cccaaccaag ctctcttgag gatcttgaag gaaactgaat tcaaaaagat caaagtgctg     2400

ggctccggtg cgttcggcac ggtgtataag ggactctgga tcccagaagg tgagaaagtt     2460

aaaattcccg tcgctatcaa ggaattaaga gaagcaacat ctccgaaagc caacaaggaa     2520

atcctcgatg aagcctacgt gatggccagc gtggacaacc cccacgtgtg ccgcctgctg     2580

ggcatctgcc tcacctccac cgtgcagctc atcacgcagc tcatgccctt cggctgcctc     2640

ctggactatg tccgggaaca caaagacaat attggctccc agtacctgct caactggtgt     2700

gtgcagatcg caaagggcat gaactacttg gaggaccgtc gcttggtgca ccgcgacctg     2760

gcagccagga acgtactggt gaaaacaccg cagcatgtca agatcacaga ttttgggctg     2820

gccaaactgc tgggtgcgga agagaaagaa taccatgcag aaggaggcaa agtgcctatc     2880

aagtggatgg cattggaatc aattttacac agaatctata cccaccagag tgatgtctgg     2940

agctacgggg tgaccgtttg ggagttgatg acctttggat ccaagccata tgacggaatc     3000

cctgccagcg agatctcctc catcctggag aaaggagaac gcctccctca gccacccata     3060

tgtaccatcg atgtctacat gatcatggtc aagtgctgga tgatagacgc agatagtcgc     3120

ccaaagttcc gtgagttgat catcgaattc tccaaaatgg cccgagaccc ccagcgctac     3180

cttgtcattc agggggatga aagaatgcat ttgccaagtc ctacagactc caacttctac     3240

cgtgccctga tggatgaaga agacatggac gacgtggtgg atgccgacga gtacctcatc     3300

ccacagcagg gcttcttcag cagcccctcc acgtcacgga ctcccctcct gagctctctg     3360

agtgcaacca gcaacaattc caccgtggct tgcattgata gaaatgggct gcaaagctgt     3420

cccatcaagg aagacagctt cttgcagcga tacagctcag accccacagg cgccttgact     3480

gaggacagca tagacgacac cttcctccca gtgcctgaat acataaacca gtccgttccc     3540

aaaaggcccg ctggctctgt gcagaatcct gtctatcaca atcagcctct gaaccccgcg     3600

cccagcagag acccacacta ccaggacccc cacagcactg cagtgggcaa ccccgagtat     3660

ctcaacactg tccagcccac ctgtgtcaac agcacattcg acagccctgc ccactgggcc     3720

cagaaaggca gccaccaaat tagcctggac aaccctgact accagcagga cttctttccc     3780

aaggaagcca agccaaatgg catctttaag ggctccacag ctgaaaatgc agaataccta     3840

agggtcgcgc cacaaagcag tgaatttatt ggagcatgac cacggaggat agtatgagcc     3900

ctaaaaatcc agactctttc gatacccagg accaagccac agcaggtcct ccatcccaac     3960

agccatgccc gcattagctc ttagacccac agactggttt tgcaacgttt acaccgacta     4020

gccaggaagt acttccacct cgggcacatt ttgggaagtt gcattccttt gtcttcaaac     4080

tgtgaagcat ttacagaaac gcatccagca agaatattgt ccctttgagc agaaatttat     4140

ctttcaaaga ggtatatttg aaaaaaaaaa aaagtatatg tgaggatttt tattgattgg     4200

ggatcttgga gtttttcatt gtcgctattg atttttactt caatgggctc ttccaacaag     4260

gaagaagctt gctggtagca cttgctaccc tgagttcatc caggcccaac tgtgagcaag     4320

gagcacaagc cacaagtctt ccagaggatg cttgattcca gtggttctgc ttcaaggctt     4380

ccactgcaaa acactaaaga tccaagaagg ccttcatggc cccagcaggc cggatcggta     4440

ctgtatcaag tcatggcagg tacagtagga taagccactc tgtcccttcc tgggcaaaga     4500

agaaacggag gggatggaat tcttccttag acttactttt gtaaaaatgt ccccacggta     4560

cttactcccc actgatggac cagtggtttc cagtcatgag cgttagactg acttgtttgt     4620

cttccattcc attgttttga aactcagtat gctgcccctg tcttgctgtc atgaaatcag     4680

caagagagga tgacacatca aataataact cggattccag cccacattgg attcatcagc     4740

atttggacca atagcccaca gctgagaatg tggaatacct aaggatagca ccgcttttgt     4800

tctcgcaaaa acgtatctcc taatttgagg ctcagatgaa atgcatcagg tcctttgggg     4860

catagatcag aagactacaa aaatgaagct gctctgaaat ctcctttagc catcacccca     4920

accccccaaa attagtttgt gttacttatg gaagatagtt ttctcctttt acttcacttc     4980

aaaagctttt tactcaaaga gtatatgttc cctccaggtc agctgccccc aaaccccctc     5040

cttacgcttt gtcacacaaa aagtgtctct gccttgagtc atctattcaa gcacttacag     5100

ctctggccac aacagggcat tttacaggtg cgaatgacag tagcattatg agtagtgtgg     5160

aattcaggta gtaaatatga aactagggtt tgaaattgat aatgctttca caacatttgc     5220

agatgtttta gaaggaaaaa agttccttcc taaaataatt tctctacaat tggaagattg     5280

gaagattcag ctagttagga gcccaccttt tttcctaatc tgtgtgtgcc ctgtaacctg     5340

actggttaac agcagtcctt tgtaaacagt gttttaaact ctcctagtca atatccaccc     5400

catccaattt atcaaggaag aaatggttca gaaaatattt tcagcctaca gttatgttca     5460

gtcacacaca catacaaaat gttccttttg cttttaaagt aatttttgac tcccagatca     5520

gtcagagccc ctacagcatt gttaagaaag tatttgattt ttgtctcaat gaaaataaaa     5580

ctatattcat ttccactcta aaaaaaaaaa aaaaaa                               5616


<210>  731
<211>  1210
<212>  PRT
<213>  Homo sapiens

<400>  731

Met Arg Pro Ser Gly Thr Ala Gly Ala Ala Leu Leu Ala Leu Leu Ala 
1               5                   10                  15      


Ala Leu Cys Pro Ala Ser Arg Ala Leu Glu Glu Lys Lys Val Cys Gln 
            20                  25                  30          


Gly Thr Ser Asn Lys Leu Thr Gln Leu Gly Thr Phe Glu Asp His Phe 
        35                  40                  45              


Leu Ser Leu Gln Arg Met Phe Asn Asn Cys Glu Val Val Leu Gly Asn 
    50                  55                  60                  


Leu Glu Ile Thr Tyr Val Gln Arg Asn Tyr Asp Leu Ser Phe Leu Lys 
65                  70                  75                  80  


Thr Ile Gln Glu Val Ala Gly Tyr Val Leu Ile Ala Leu Asn Thr Val 
                85                  90                  95      


Glu Arg Ile Pro Leu Glu Asn Leu Gln Ile Ile Arg Gly Asn Met Tyr 
            100                 105                 110         


Tyr Glu Asn Ser Tyr Ala Leu Ala Val Leu Ser Asn Tyr Asp Ala Asn 
        115                 120                 125             


Lys Thr Gly Leu Lys Glu Leu Pro Met Arg Asn Leu Gln Glu Ile Leu 
    130                 135                 140                 


His Gly Ala Val Arg Phe Ser Asn Asn Pro Ala Leu Cys Asn Val Glu 
145                 150                 155                 160 


Ser Ile Gln Trp Arg Asp Ile Val Ser Ser Asp Phe Leu Ser Asn Met 
                165                 170                 175     


Ser Met Asp Phe Gln Asn His Leu Gly Ser Cys Gln Lys Cys Asp Pro 
            180                 185                 190         


Ser Cys Pro Asn Gly Ser Cys Trp Gly Ala Gly Glu Glu Asn Cys Gln 
        195                 200                 205             


Lys Leu Thr Lys Ile Ile Cys Ala Gln Gln Cys Ser Gly Arg Cys Arg 
    210                 215                 220                 


Gly Lys Ser Pro Ser Asp Cys Cys His Asn Gln Cys Ala Ala Gly Cys 
225                 230                 235                 240 


Thr Gly Pro Arg Glu Ser Asp Cys Leu Val Cys Arg Lys Phe Arg Asp 
                245                 250                 255     


Glu Ala Thr Cys Lys Asp Thr Cys Pro Pro Leu Met Leu Tyr Asn Pro 
            260                 265                 270         


Thr Thr Tyr Gln Met Asp Val Asn Pro Glu Gly Lys Tyr Ser Phe Gly 
        275                 280                 285             


Ala Thr Cys Val Lys Lys Cys Pro Arg Asn Tyr Val Val Thr Asp His 
    290                 295                 300                 


Gly Ser Cys Val Arg Ala Cys Gly Ala Asp Ser Tyr Glu Met Glu Glu 
305                 310                 315                 320 


Asp Gly Val Arg Lys Cys Lys Lys Cys Glu Gly Pro Cys Arg Lys Val 
                325                 330                 335     


Cys Asn Gly Ile Gly Ile Gly Glu Phe Lys Asp Ser Leu Ser Ile Asn 
            340                 345                 350         


Ala Thr Asn Ile Lys His Phe Lys Asn Cys Thr Ser Ile Ser Gly Asp 
        355                 360                 365             


Leu His Ile Leu Pro Val Ala Phe Arg Gly Asp Ser Phe Thr His Thr 
    370                 375                 380                 


Pro Pro Leu Asp Pro Gln Glu Leu Asp Ile Leu Lys Thr Val Lys Glu 
385                 390                 395                 400 


Ile Thr Gly Phe Leu Leu Ile Gln Ala Trp Pro Glu Asn Arg Thr Asp 
                405                 410                 415     


Leu His Ala Phe Glu Asn Leu Glu Ile Ile Arg Gly Arg Thr Lys Gln 
            420                 425                 430         


His Gly Gln Phe Ser Leu Ala Val Val Ser Leu Asn Ile Thr Ser Leu 
        435                 440                 445             


Gly Leu Arg Ser Leu Lys Glu Ile Ser Asp Gly Asp Val Ile Ile Ser 
    450                 455                 460                 


Gly Asn Lys Asn Leu Cys Tyr Ala Asn Thr Ile Asn Trp Lys Lys Leu 
465                 470                 475                 480 


Phe Gly Thr Ser Gly Gln Lys Thr Lys Ile Ile Ser Asn Arg Gly Glu 
                485                 490                 495     


Asn Ser Cys Lys Ala Thr Gly Gln Val Cys His Ala Leu Cys Ser Pro 
            500                 505                 510         


Glu Gly Cys Trp Gly Pro Glu Pro Arg Asp Cys Val Ser Cys Arg Asn 
        515                 520                 525             


Val Ser Arg Gly Arg Glu Cys Val Asp Lys Cys Asn Leu Leu Glu Gly 
    530                 535                 540                 


Glu Pro Arg Glu Phe Val Glu Asn Ser Glu Cys Ile Gln Cys His Pro 
545                 550                 555                 560 


Glu Cys Leu Pro Gln Ala Met Asn Ile Thr Cys Thr Gly Arg Gly Pro 
                565                 570                 575     


Asp Asn Cys Ile Gln Cys Ala His Tyr Ile Asp Gly Pro His Cys Val 
            580                 585                 590         


Lys Thr Cys Pro Ala Gly Val Met Gly Glu Asn Asn Thr Leu Val Trp 
        595                 600                 605             


Lys Tyr Ala Asp Ala Gly His Val Cys His Leu Cys His Pro Asn Cys 
    610                 615                 620                 


Thr Tyr Gly Cys Thr Gly Pro Gly Leu Glu Gly Cys Pro Thr Asn Gly 
625                 630                 635                 640 


Pro Lys Ile Pro Ser Ile Ala Thr Gly Met Val Gly Ala Leu Leu Leu 
                645                 650                 655     


Leu Leu Val Val Ala Leu Gly Ile Gly Leu Phe Met Arg Arg Arg His 
            660                 665                 670         


Ile Val Arg Lys Arg Thr Leu Arg Arg Leu Leu Gln Glu Arg Glu Leu 
        675                 680                 685             


Val Glu Pro Leu Thr Pro Ser Gly Glu Ala Pro Asn Gln Ala Leu Leu 
    690                 695                 700                 


Arg Ile Leu Lys Glu Thr Glu Phe Lys Lys Ile Lys Val Leu Gly Ser 
705                 710                 715                 720 


Gly Ala Phe Gly Thr Val Tyr Lys Gly Leu Trp Ile Pro Glu Gly Glu 
                725                 730                 735     


Lys Val Lys Ile Pro Val Ala Ile Lys Glu Leu Arg Glu Ala Thr Ser 
            740                 745                 750         


Pro Lys Ala Asn Lys Glu Ile Leu Asp Glu Ala Tyr Val Met Ala Ser 
        755                 760                 765             


Val Asp Asn Pro His Val Cys Arg Leu Leu Gly Ile Cys Leu Thr Ser 
    770                 775                 780                 


Thr Val Gln Leu Ile Thr Gln Leu Met Pro Phe Gly Cys Leu Leu Asp 
785                 790                 795                 800 


Tyr Val Arg Glu His Lys Asp Asn Ile Gly Ser Gln Tyr Leu Leu Asn 
                805                 810                 815     


Trp Cys Val Gln Ile Ala Lys Gly Met Asn Tyr Leu Glu Asp Arg Arg 
            820                 825                 830         


Leu Val His Arg Asp Leu Ala Ala Arg Asn Val Leu Val Lys Thr Pro 
        835                 840                 845             


Gln His Val Lys Ile Thr Asp Phe Gly Leu Ala Lys Leu Leu Gly Ala 
    850                 855                 860                 


Glu Glu Lys Glu Tyr His Ala Glu Gly Gly Lys Val Pro Ile Lys Trp 
865                 870                 875                 880 


Met Ala Leu Glu Ser Ile Leu His Arg Ile Tyr Thr His Gln Ser Asp 
                885                 890                 895     


Val Trp Ser Tyr Gly Val Thr Val Trp Glu Leu Met Thr Phe Gly Ser 
            900                 905                 910         


Lys Pro Tyr Asp Gly Ile Pro Ala Ser Glu Ile Ser Ser Ile Leu Glu 
        915                 920                 925             


Lys Gly Glu Arg Leu Pro Gln Pro Pro Ile Cys Thr Ile Asp Val Tyr 
    930                 935                 940                 


Met Ile Met Val Lys Cys Trp Met Ile Asp Ala Asp Ser Arg Pro Lys 
945                 950                 955                 960 


Phe Arg Glu Leu Ile Ile Glu Phe Ser Lys Met Ala Arg Asp Pro Gln 
                965                 970                 975     


Arg Tyr Leu Val Ile Gln Gly Asp Glu Arg Met His Leu Pro Ser Pro 
            980                 985                 990         


Thr Asp Ser Asn Phe Tyr Arg Ala  Leu Met Asp Glu Glu  Asp Met Asp 
        995                 1000                 1005             


Asp Val  Val Asp Ala Asp Glu  Tyr Leu Ile Pro Gln  Gln Gly Phe 
    1010                 1015                 1020             


Phe Ser  Ser Pro Ser Thr Ser  Arg Thr Pro Leu Leu  Ser Ser Leu 
    1025                 1030                 1035             


Ser Ala  Thr Ser Asn Asn Ser  Thr Val Ala Cys Ile  Asp Arg Asn 
    1040                 1045                 1050             


Gly Leu  Gln Ser Cys Pro Ile  Lys Glu Asp Ser Phe  Leu Gln Arg 
    1055                 1060                 1065             


Tyr Ser  Ser Asp Pro Thr Gly  Ala Leu Thr Glu Asp  Ser Ile Asp 
    1070                 1075                 1080             


Asp Thr  Phe Leu Pro Val Pro  Glu Tyr Ile Asn Gln  Ser Val Pro 
    1085                 1090                 1095             


Lys Arg  Pro Ala Gly Ser Val  Gln Asn Pro Val Tyr  His Asn Gln 
    1100                 1105                 1110             


Pro Leu  Asn Pro Ala Pro Ser  Arg Asp Pro His Tyr  Gln Asp Pro 
    1115                 1120                 1125             


His Ser  Thr Ala Val Gly Asn  Pro Glu Tyr Leu Asn  Thr Val Gln 
    1130                 1135                 1140             


Pro Thr  Cys Val Asn Ser Thr  Phe Asp Ser Pro Ala  His Trp Ala 
    1145                 1150                 1155             


Gln Lys  Gly Ser His Gln Ile  Ser Leu Asp Asn Pro  Asp Tyr Gln 
    1160                 1165                 1170             


Gln Asp  Phe Phe Pro Lys Glu  Ala Lys Pro Asn Gly  Ile Phe Lys 
    1175                 1180                 1185             


Gly Ser  Thr Ala Glu Asn Ala  Glu Tyr Leu Arg Val  Ala Pro Gln 
    1190                 1195                 1200             


Ser Ser  Glu Phe Ile Gly Ala  
    1205                 1210 


<210>  732
<211>  571
<212>  PRT
<213>  Homo sapiens

<400>  732

His Asn Gln Thr Ser Leu Tyr Lys Lys Ala Gly Ser Ala Ala Ala Val 
1               5                   10                  15      


Leu Glu Glu Asn Leu Tyr Phe Gln Gly Ser Phe Thr Met Arg Arg Arg 
            20                  25                  30          


His Ile Val Arg Lys Arg Thr Leu Arg Arg Leu Leu Gln Glu Arg Glu 
        35                  40                  45              


Leu Val Glu Pro Leu Thr Pro Ser Gly Glu Ala Pro Asn Gln Ala Leu 
    50                  55                  60                  


Leu Arg Ile Leu Lys Glu Thr Glu Phe Lys Lys Ile Lys Val Leu Gly 
65                  70                  75                  80  


Ser Gly Ala Phe Gly Thr Val Tyr Lys Gly Leu Trp Ile Pro Glu Gly 
                85                  90                  95      


Glu Lys Val Lys Ile Pro Val Ala Ile Lys Glu Leu Arg Glu Ala Thr 
            100                 105                 110         


Ser Pro Lys Ala Asn Lys Glu Ile Leu Asp Glu Ala Tyr Val Met Ala 
        115                 120                 125             


Ser Val Asp Asn Pro His Val Cys Arg Leu Leu Gly Ile Cys Leu Thr 
    130                 135                 140                 


Ser Thr Val Gln Leu Ile Thr Gln Leu Met Pro Phe Gly Cys Leu Leu 
145                 150                 155                 160 


Asp Tyr Val Arg Glu His Lys Asp Asn Ile Gly Ser Gln Tyr Leu Leu 
                165                 170                 175     


Asn Trp Cys Val Gln Ile Ala Lys Gly Met Asn Tyr Leu Glu Asp Arg 
            180                 185                 190         


Arg Leu Val His Arg Asp Leu Ala Ala Arg Asn Val Leu Val Lys Thr 
        195                 200                 205             


Pro Gln His Val Lys Ile Thr Asp Phe Gly Leu Ala Lys Leu Leu Gly 
    210                 215                 220                 


Ala Glu Glu Lys Glu Tyr His Ala Glu Gly Gly Lys Val Pro Ile Lys 
225                 230                 235                 240 


Trp Met Ala Leu Glu Ser Ile Leu His Arg Ile Tyr Thr His Gln Ser 
                245                 250                 255     


Asp Val Trp Ser Tyr Gly Val Thr Val Trp Glu Leu Met Thr Phe Gly 
            260                 265                 270         


Ser Lys Pro Tyr Asp Gly Ile Pro Ala Ser Glu Ile Ser Ser Ile Leu 
        275                 280                 285             


Glu Lys Gly Glu Arg Leu Pro Gln Pro Pro Ile Cys Thr Ile Asp Val 
    290                 295                 300                 


Tyr Met Ile Met Val Lys Cys Trp Met Ile Asp Ala Asp Ser Arg Pro 
305                 310                 315                 320 


Lys Phe Arg Glu Leu Ile Ile Glu Phe Ser Lys Met Ala Arg Asp Pro 
                325                 330                 335     


Gln Arg Tyr Leu Val Ile Gln Gly Asp Glu Arg Met His Leu Pro Ser 
            340                 345                 350         


Pro Thr Asp Ser Asn Phe Tyr Arg Ala Leu Met Asp Glu Glu Asp Met 
        355                 360                 365             


Asp Asp Val Val Asp Ala Asp Glu Tyr Leu Ile Pro Gln Gln Gly Phe 
    370                 375                 380                 


Phe Ser Ser Pro Ser Thr Ser Arg Thr Pro Leu Leu Ser Ser Leu Ser 
385                 390                 395                 400 


Ala Thr Ser Asn Asn Ser Thr Val Ala Cys Ile Asp Arg Asn Gly Leu 
                405                 410                 415     


Gln Ser Cys Pro Ile Lys Glu Asp Ser Phe Leu Gln Arg Tyr Ser Ser 
            420                 425                 430         


Asp Pro Thr Gly Ala Leu Thr Glu Asp Ser Ile Asp Asp Thr Phe Leu 
        435                 440                 445             


Pro Val Pro Glu Tyr Ile Asn Gln Ser Val Pro Lys Arg Pro Ala Gly 
    450                 455                 460                 


Ser Val Gln Asn Pro Val Tyr His Asn Gln Pro Leu Asn Pro Ala Pro 
465                 470                 475                 480 


Ser Arg Asp Pro His Tyr Gln Asp Pro His Ser Thr Ala Val Gly Asn 
                485                 490                 495     


Pro Glu Tyr Leu Asn Thr Val Gln Pro Thr Cys Val Asn Ser Thr Phe 
            500                 505                 510         


Asp Ser Pro Ala His Trp Ala Gln Lys Gly Ser His Gln Ile Ser Leu 
        515                 520                 525             


Asp Asn Pro Asp Tyr Gln Gln Asp Phe Phe Pro Lys Glu Ala Lys Pro 
    530                 535                 540                 


Asn Gly Ile Phe Lys Gly Ser Thr Ala Glu Asn Ala Glu Tyr Leu Arg 
545                 550                 555                 560 


Val Ala Pro Gln Ser Ser Glu Phe Ile Gly Ala 
                565                 570     


<210>  733
<211>  5616
<212>  DNA
<213>  Homo sapiens

<400>  733
ccccggcgca gcgcggccgc agcagcctcc gccccccgca cggtgtgagc gcccgacgcg       60

gccgaggcgg ccggagtccc gagctagccc cggcggccgc cgccgcccag accggacgac      120

aggccacctc gtcggcgtcc gcccgagtcc ccgcctcgcc gccaacgcca caaccaccgc      180

gcacggcccc ctgactccgt ccagtattga tcgggagagc cggagcgagc tcttcgggga      240

gcagcgatgc gaccctccgg gacggccggg gcagcgctcc tggcgctgct ggctgcgctc      300

tgcccggcga gtcgggctct ggaggaaaag aaagtttgcc aaggcacgag taacaagctc      360

acgcagttgg gcacttttga agatcatttt ctcagcctcc agaggatgtt caataactgt      420

gaggtggtcc ttgggaattt ggaaattacc tatgtgcaga ggaattatga tctttccttc      480

ttaaagacca tccaggaggt ggctggttat gtcctcattg ccctcaacac agtggagcga      540

attcctttgg aaaacctgca gatcatcaga ggaaatatgt actacgaaaa ttcctatgcc      600

ttagcagtct tatctaacta tgatgcaaat aaaaccggac tgaaggagct gcccatgaga      660

aatttacagg aaatcctgca tggcgccgtg cggttcagca acaaccctgc cctgtgcaac      720

gtggagagca tccagtggcg ggacatagtc agcagtgact ttctcagcaa catgtcgatg      780

gacttccaga accacctggg cagctgccaa aagtgtgatc caagctgtcc caatgggagc      840

tgctggggtg caggagagga gaactgccag aaactgacca aaatcatctg tgcccagcag      900

tgctccgggc gctgccgtgg caagtccccc agtgactgct gccacaacca gtgtgctgca      960

ggctgcacag gcccccggga gagcgactgc ctggtctgcc gcaaattccg agacgaagcc     1020

acgtgcaagg acacctgccc cccactcatg ctctacaacc ccaccacgta ccagatggat     1080

gtgaaccccg agggcaaata cagctttggt gccacctgcg tgaagaagtg tccccgtaat     1140

tatgtggtga cagatcacgg ctcgtgcgtc cgagcctgtg gggccgacag ctatgagatg     1200

gaggaagacg gcgtccgcaa gtgtaagaag tgcgaagggc cttgccgcaa agtgtgtaac     1260

ggaataggta ttggtgaatt taaagactca ctctccataa atgctacgaa tattaaacac     1320

ttcaaaaact gcacctccat cagtggcgat ctccacatcc tgccggtggc atttaggggt     1380

gactccttca cacatactcc tcctctggat ccacaggaac tggatattct gaaaaccgta     1440

aaggaaatca cagggttttt gctgattcag gcttggcctg aaaacaggac ggacctccat     1500

gcctttgaga acctagaaat catacgcggc aggaccaagc aacatggtca gttttctctt     1560

gcagtcgtca gcctgaacat aacatccttg ggattacgct ccctcaagga gataagtgat     1620

ggagatgtga taatttcagg aaacaaaaat ttgtgctatg caaatacaat aaactggaaa     1680

aaactgtttg ggacctccgg tcagaaaacc aaaattataa gcaacagagg tgaaaacagc     1740

tgcaaggcca caggccaggt ctgccatgcc ttgtgctccc ccgagggctg ctggggcccg     1800

gagcccaggg actgcgtctc ttgccggaat gtcagccgag gcagggaatg cgtggacaag     1860

tgcaaccttc tggagggtga gccaagggag tttgtggaga actctgagtg catacagtgc     1920

cacccagagt gcctgcctca ggccatgaac atcacctgca caggacgggg accagacaac     1980

tgtatccagt gtgcccacta cattgacggc ccccactgcg tcaagacctg cccggcagga     2040

gtcatgggag aaaacaacac cctggtctgg aagtacgcag acgccggcca tgtgtgccac     2100

ctgtgccatc caaactgcac ctacggatgc actgggccag gtcttgaagg ctgtccaacg     2160

aatgggccta agatcccgtc catcgccact gggatggtgg gggccctcct cttgctgctg     2220

gtggtggccc tggggatcgg cctcttcatg cgaaggcgcc acatcgttcg gaagcgcacg     2280

ctgcggaggc tgctgcagga gagggagctt gtggagcctc ttacacccag tggagaagct     2340

cccaaccaag ctctcttgag gatcttgaag gaaactgaat tcaaaaagat caaagtgctg     2400

ggctccggtg cgttcggcac ggtgtataag ggactctgga tcccagaagg tgagaaagtt     2460

aaaattcccg tcgctatcaa ggaattaaga gaagcaacat ctccgaaagc caacaaggaa     2520

atcctcgatg aagcctacgt gatggccagc gtggacaacc cccacgtgtg ccgcctgctg     2580

ggcatctgcc tcacctccac cgtgcagctc atcacgcagc tcatgccctt cggctgcctc     2640

ctggactatg tccgggaaca caaagacaat attggctccc agtacctgct caactggtgt     2700

gtgcagatcg caaagggcat gaactacttg gaggaccgtc gcttggtgca ccgcgacctg     2760

gcagccagga acgtactggt gaaaacaccg cagcatgtca agatcacaga ttttgggctg     2820

gccaaactgc tgggtgcgga agagaaagaa taccatgcag aaggaggcaa agtgcctatc     2880

aagtggatgg cattggaatc aattttacac agaatctata cccaccagag tgatgtctgg     2940

agctacgggg tgaccgtttg ggagttgatg acctttggat ccaagccata tgacggaatc     3000

cctgccagcg agatctcctc catcctggag aaaggagaac gcctccctca gccacccata     3060

tgtaccatcg atgtctacat gatcatggtc aagtgctgga tgatagacgc agatagtcgc     3120

ccaaagttcc gtgagttgat catcgaattc tccaaaatgg cccgagaccc ccagcgctac     3180

cttgtcattc agggggatga aagaatgcat ttgccaagtc ctacagactc caacttctac     3240

cgtgccctga tggatgaaga agacatggac gacgtggtgg atgccgacga gtacctcatc     3300

ccacagcagg gcttcttcag cagcccctcc acgtcacgga ctcccctcct gagctctctg     3360

agtgcaacca gcaacaattc caccgtggct tgcattgata gaaatgggct gcaaagctgt     3420

cccatcaagg aagacagctt cttgcagcga tacagctcag accccacagg cgccttgact     3480

gaggacagca tagacgacac cttcctccca gtgcctgaat acataaacca gtccgttccc     3540

aaaaggcccg ctggctctgt gcagaatcct gtctatcaca atcagcctct gaaccccgcg     3600

cccagcagag acccacacta ccaggacccc cacagcactg cagtgggcaa ccccgagtat     3660

ctcaacactg tccagcccac ctgtgtcaac agcacattcg acagccctgc ccactgggcc     3720

cagaaaggca gccaccaaat tagcctggac aaccctgact accagcagga cttctttccc     3780

aaggaagcca agccaaatgg catctttaag ggctccacag ctgaaaatgc agaataccta     3840

agggtcgcgc cacaaagcag tgaatttatt ggagcatgac cacggaggat agtatgagcc     3900

ctaaaaatcc agactctttc gatacccagg accaagccac agcaggtcct ccatcccaac     3960

agccatgccc gcattagctc ttagacccac agactggttt tgcaacgttt acaccgacta     4020

gccaggaagt acttccacct cgggcacatt ttgggaagtt gcattccttt gtcttcaaac     4080

tgtgaagcat ttacagaaac gcatccagca agaatattgt ccctttgagc agaaatttat     4140

ctttcaaaga ggtatatttg aaaaaaaaaa aaagtatatg tgaggatttt tattgattgg     4200

ggatcttgga gtttttcatt gtcgctattg atttttactt caatgggctc ttccaacaag     4260

gaagaagctt gctggtagca cttgctaccc tgagttcatc caggcccaac tgtgagcaag     4320

gagcacaagc cacaagtctt ccagaggatg cttgattcca gtggttctgc ttcaaggctt     4380

ccactgcaaa acactaaaga tccaagaagg ccttcatggc cccagcaggc cggatcggta     4440

ctgtatcaag tcatggcagg tacagtagga taagccactc tgtcccttcc tgggcaaaga     4500

agaaacggag gggatggaat tcttccttag acttactttt gtaaaaatgt ccccacggta     4560

cttactcccc actgatggac cagtggtttc cagtcatgag cgttagactg acttgtttgt     4620

cttccattcc attgttttga aactcagtat gctgcccctg tcttgctgtc atgaaatcag     4680

caagagagga tgacacatca aataataact cggattccag cccacattgg attcatcagc     4740

atttggacca atagcccaca gctgagaatg tggaatacct aaggatagca ccgcttttgt     4800

tctcgcaaaa acgtatctcc taatttgagg ctcagatgaa atgcatcagg tcctttgggg     4860

catagatcag aagactacaa aaatgaagct gctctgaaat ctcctttagc catcacccca     4920

accccccaaa attagtttgt gttacttatg gaagatagtt ttctcctttt acttcacttc     4980

aaaagctttt tactcaaaga gtatatgttc cctccaggtc agctgccccc aaaccccctc     5040

cttacgcttt gtcacacaaa aagtgtctct gccttgagtc atctattcaa gcacttacag     5100

ctctggccac aacagggcat tttacaggtg cgaatgacag tagcattatg agtagtgtgg     5160

aattcaggta gtaaatatga aactagggtt tgaaattgat aatgctttca caacatttgc     5220

agatgtttta gaaggaaaaa agttccttcc taaaataatt tctctacaat tggaagattg     5280

gaagattcag ctagttagga gcccaccttt tttcctaatc tgtgtgtgcc ctgtaacctg     5340

actggttaac agcagtcctt tgtaaacagt gttttaaact ctcctagtca atatccaccc     5400

catccaattt atcaaggaag aaatggttca gaaaatattt tcagcctaca gttatgttca     5460

gtcacacaca catacaaaat gttccttttg cttttaaagt aatttttgac tcccagatca     5520

gtcagagccc ctacagcatt gttaagaaag tatttgattt ttgtctcaat gaaaataaaa     5580

ctatattcat ttccactcta aaaaaaaaaa aaaaaa                               5616


<210>  734
<211>  1210
<212>  PRT
<213>  Homo sapiens

<400>  734

Met Arg Pro Ser Gly Thr Ala Gly Ala Ala Leu Leu Ala Leu Leu Ala 
1               5                   10                  15      


Ala Leu Cys Pro Ala Ser Arg Ala Leu Glu Glu Lys Lys Val Cys Gln 
            20                  25                  30          


Gly Thr Ser Asn Lys Leu Thr Gln Leu Gly Thr Phe Glu Asp His Phe 
        35                  40                  45              


Leu Ser Leu Gln Arg Met Phe Asn Asn Cys Glu Val Val Leu Gly Asn 
    50                  55                  60                  


Leu Glu Ile Thr Tyr Val Gln Arg Asn Tyr Asp Leu Ser Phe Leu Lys 
65                  70                  75                  80  


Thr Ile Gln Glu Val Ala Gly Tyr Val Leu Ile Ala Leu Asn Thr Val 
                85                  90                  95      


Glu Arg Ile Pro Leu Glu Asn Leu Gln Ile Ile Arg Gly Asn Met Tyr 
            100                 105                 110         


Tyr Glu Asn Ser Tyr Ala Leu Ala Val Leu Ser Asn Tyr Asp Ala Asn 
        115                 120                 125             


Lys Thr Gly Leu Lys Glu Leu Pro Met Arg Asn Leu Gln Glu Ile Leu 
    130                 135                 140                 


His Gly Ala Val Arg Phe Ser Asn Asn Pro Ala Leu Cys Asn Val Glu 
145                 150                 155                 160 


Ser Ile Gln Trp Arg Asp Ile Val Ser Ser Asp Phe Leu Ser Asn Met 
                165                 170                 175     


Ser Met Asp Phe Gln Asn His Leu Gly Ser Cys Gln Lys Cys Asp Pro 
            180                 185                 190         


Ser Cys Pro Asn Gly Ser Cys Trp Gly Ala Gly Glu Glu Asn Cys Gln 
        195                 200                 205             


Lys Leu Thr Lys Ile Ile Cys Ala Gln Gln Cys Ser Gly Arg Cys Arg 
    210                 215                 220                 


Gly Lys Ser Pro Ser Asp Cys Cys His Asn Gln Cys Ala Ala Gly Cys 
225                 230                 235                 240 


Thr Gly Pro Arg Glu Ser Asp Cys Leu Val Cys Arg Lys Phe Arg Asp 
                245                 250                 255     


Glu Ala Thr Cys Lys Asp Thr Cys Pro Pro Leu Met Leu Tyr Asn Pro 
            260                 265                 270         


Thr Thr Tyr Gln Met Asp Val Asn Pro Glu Gly Lys Tyr Ser Phe Gly 
        275                 280                 285             


Ala Thr Cys Val Lys Lys Cys Pro Arg Asn Tyr Val Val Thr Asp His 
    290                 295                 300                 


Gly Ser Cys Val Arg Ala Cys Gly Ala Asp Ser Tyr Glu Met Glu Glu 
305                 310                 315                 320 


Asp Gly Val Arg Lys Cys Lys Lys Cys Glu Gly Pro Cys Arg Lys Val 
                325                 330                 335     


Cys Asn Gly Ile Gly Ile Gly Glu Phe Lys Asp Ser Leu Ser Ile Asn 
            340                 345                 350         


Ala Thr Asn Ile Lys His Phe Lys Asn Cys Thr Ser Ile Ser Gly Asp 
        355                 360                 365             


Leu His Ile Leu Pro Val Ala Phe Arg Gly Asp Ser Phe Thr His Thr 
    370                 375                 380                 


Pro Pro Leu Asp Pro Gln Glu Leu Asp Ile Leu Lys Thr Val Lys Glu 
385                 390                 395                 400 


Ile Thr Gly Phe Leu Leu Ile Gln Ala Trp Pro Glu Asn Arg Thr Asp 
                405                 410                 415     


Leu His Ala Phe Glu Asn Leu Glu Ile Ile Arg Gly Arg Thr Lys Gln 
            420                 425                 430         


His Gly Gln Phe Ser Leu Ala Val Val Ser Leu Asn Ile Thr Ser Leu 
        435                 440                 445             


Gly Leu Arg Ser Leu Lys Glu Ile Ser Asp Gly Asp Val Ile Ile Ser 
    450                 455                 460                 


Gly Asn Lys Asn Leu Cys Tyr Ala Asn Thr Ile Asn Trp Lys Lys Leu 
465                 470                 475                 480 


Phe Gly Thr Ser Gly Gln Lys Thr Lys Ile Ile Ser Asn Arg Gly Glu 
                485                 490                 495     


Asn Ser Cys Lys Ala Thr Gly Gln Val Cys His Ala Leu Cys Ser Pro 
            500                 505                 510         


Glu Gly Cys Trp Gly Pro Glu Pro Arg Asp Cys Val Ser Cys Arg Asn 
        515                 520                 525             


Val Ser Arg Gly Arg Glu Cys Val Asp Lys Cys Asn Leu Leu Glu Gly 
    530                 535                 540                 


Glu Pro Arg Glu Phe Val Glu Asn Ser Glu Cys Ile Gln Cys His Pro 
545                 550                 555                 560 


Glu Cys Leu Pro Gln Ala Met Asn Ile Thr Cys Thr Gly Arg Gly Pro 
                565                 570                 575     


Asp Asn Cys Ile Gln Cys Ala His Tyr Ile Asp Gly Pro His Cys Val 
            580                 585                 590         


Lys Thr Cys Pro Ala Gly Val Met Gly Glu Asn Asn Thr Leu Val Trp 
        595                 600                 605             


Lys Tyr Ala Asp Ala Gly His Val Cys His Leu Cys His Pro Asn Cys 
    610                 615                 620                 


Thr Tyr Gly Cys Thr Gly Pro Gly Leu Glu Gly Cys Pro Thr Asn Gly 
625                 630                 635                 640 


Pro Lys Ile Pro Ser Ile Ala Thr Gly Met Val Gly Ala Leu Leu Leu 
                645                 650                 655     


Leu Leu Val Val Ala Leu Gly Ile Gly Leu Phe Met Arg Arg Arg His 
            660                 665                 670         


Ile Val Arg Lys Arg Thr Leu Arg Arg Leu Leu Gln Glu Arg Glu Leu 
        675                 680                 685             


Val Glu Pro Leu Thr Pro Ser Gly Glu Ala Pro Asn Gln Ala Leu Leu 
    690                 695                 700                 


Arg Ile Leu Lys Glu Thr Glu Phe Lys Lys Ile Lys Val Leu Gly Ser 
705                 710                 715                 720 


Gly Ala Phe Gly Thr Val Tyr Lys Gly Leu Trp Ile Pro Glu Gly Glu 
                725                 730                 735     


Lys Val Lys Ile Pro Val Ala Ile Lys Glu Leu Arg Glu Ala Thr Ser 
            740                 745                 750         


Pro Lys Ala Asn Lys Glu Ile Leu Asp Glu Ala Tyr Val Met Ala Ser 
        755                 760                 765             


Val Asp Asn Pro His Val Cys Arg Leu Leu Gly Ile Cys Leu Thr Ser 
    770                 775                 780                 


Thr Val Gln Leu Ile Met Gln Leu Met Pro Phe Gly Cys Leu Leu Asp 
785                 790                 795                 800 


Tyr Val Arg Glu His Lys Asp Asn Ile Gly Ser Gln Tyr Leu Leu Asn 
                805                 810                 815     


Trp Cys Val Gln Ile Ala Lys Gly Met Asn Tyr Leu Glu Asp Arg Arg 
            820                 825                 830         


Leu Val His Arg Asp Leu Ala Ala Arg Asn Val Leu Val Lys Thr Pro 
        835                 840                 845             


Gln His Val Lys Ile Thr Asp Phe Gly Leu Ala Lys Leu Leu Gly Ala 
    850                 855                 860                 


Glu Glu Lys Glu Tyr His Ala Glu Gly Gly Lys Val Pro Ile Lys Trp 
865                 870                 875                 880 


Met Ala Leu Glu Ser Ile Leu His Arg Ile Tyr Thr His Gln Ser Asp 
                885                 890                 895     


Val Trp Ser Tyr Gly Val Thr Val Trp Glu Leu Met Thr Phe Gly Ser 
            900                 905                 910         


Lys Pro Tyr Asp Gly Ile Pro Ala Ser Glu Ile Ser Ser Ile Leu Glu 
        915                 920                 925             


Lys Gly Glu Arg Leu Pro Gln Pro Pro Ile Cys Thr Ile Asp Val Tyr 
    930                 935                 940                 


Met Ile Met Val Lys Cys Trp Met Ile Asp Ala Asp Ser Arg Pro Lys 
945                 950                 955                 960 


Phe Arg Glu Leu Ile Ile Glu Phe Ser Lys Met Ala Arg Asp Pro Gln 
                965                 970                 975     


Arg Tyr Leu Val Ile Gln Gly Asp Glu Arg Met His Leu Pro Ser Pro 
            980                 985                 990         


Thr Asp Ser Asn Phe Tyr Arg Ala  Leu Met Asp Glu Glu  Asp Met Asp 
        995                 1000                 1005             


Asp Val  Val Asp Ala Asp Glu  Tyr Leu Ile Pro Gln  Gln Gly Phe 
    1010                 1015                 1020             


Phe Ser  Ser Pro Ser Thr Ser  Arg Thr Pro Leu Leu  Ser Ser Leu 
    1025                 1030                 1035             


Ser Ala  Thr Ser Asn Asn Ser  Thr Val Ala Cys Ile  Asp Arg Asn 
    1040                 1045                 1050             


Gly Leu  Gln Ser Cys Pro Ile  Lys Glu Asp Ser Phe  Leu Gln Arg 
    1055                 1060                 1065             


Tyr Ser  Ser Asp Pro Thr Gly  Ala Leu Thr Glu Asp  Ser Ile Asp 
    1070                 1075                 1080             


Asp Thr  Phe Leu Pro Val Pro  Glu Tyr Ile Asn Gln  Ser Val Pro 
    1085                 1090                 1095             


Lys Arg  Pro Ala Gly Ser Val  Gln Asn Pro Val Tyr  His Asn Gln 
    1100                 1105                 1110             


Pro Leu  Asn Pro Ala Pro Ser  Arg Asp Pro His Tyr  Gln Asp Pro 
    1115                 1120                 1125             


His Ser  Thr Ala Val Gly Asn  Pro Glu Tyr Leu Asn  Thr Val Gln 
    1130                 1135                 1140             


Pro Thr  Cys Val Asn Ser Thr  Phe Asp Ser Pro Ala  His Trp Ala 
    1145                 1150                 1155             


Gln Lys  Gly Ser His Gln Ile  Ser Leu Asp Asn Pro  Asp Tyr Gln 
    1160                 1165                 1170             


Gln Asp  Phe Phe Pro Lys Glu  Ala Lys Pro Asn Gly  Ile Phe Lys 
    1175                 1180                 1185             


Gly Ser  Thr Ala Glu Asn Ala  Glu Tyr Leu Arg Val  Ala Pro Gln 
    1190                 1195                 1200             


Ser Ser  Glu Phe Ile Gly Ala  
    1205                 1210 


<210>  735
<211>  543
<212>  PRT
<213>  Homo sapiens

<400>  735

Met Arg Arg Arg His Ile Val Arg Lys Arg Thr Leu Arg Arg Leu Leu 
1               5                   10                  15      


Gln Glu Arg Glu Leu Val Glu Pro Leu Thr Pro Ser Gly Glu Ala Pro 
            20                  25                  30          


Asn Gln Ala Leu Leu Arg Ile Leu Lys Glu Thr Glu Phe Lys Lys Ile 
        35                  40                  45              


Lys Val Leu Gly Ser Gly Ala Phe Gly Thr Val Tyr Lys Gly Leu Trp 
    50                  55                  60                  


Ile Pro Glu Gly Glu Lys Val Lys Ile Pro Val Ala Ile Lys Glu Leu 
65                  70                  75                  80  


Arg Glu Ala Thr Ser Pro Lys Ala Asn Lys Glu Ile Leu Asp Glu Ala 
                85                  90                  95      


Tyr Val Met Ala Ser Val Asp Asn Pro His Val Cys Arg Leu Leu Gly 
            100                 105                 110         


Ile Cys Leu Thr Ser Thr Val Gln Leu Ile Met Gln Leu Met Pro Phe 
        115                 120                 125             


Gly Cys Leu Leu Asp Tyr Val Arg Glu His Lys Asp Asn Ile Gly Ser 
    130                 135                 140                 


Gln Tyr Leu Leu Asn Trp Cys Val Gln Ile Ala Lys Gly Met Asn Tyr 
145                 150                 155                 160 


Leu Glu Asp Arg Arg Leu Val His Arg Asp Leu Ala Ala Arg Asn Val 
                165                 170                 175     


Leu Val Lys Thr Pro Gln His Val Lys Ile Thr Asp Phe Gly Leu Ala 
            180                 185                 190         


Lys Leu Leu Gly Ala Glu Glu Lys Glu Tyr His Ala Glu Gly Gly Lys 
        195                 200                 205             


Val Pro Ile Lys Trp Met Ala Leu Glu Ser Ile Leu His Arg Ile Tyr 
    210                 215                 220                 


Thr His Gln Ser Asp Val Trp Ser Tyr Gly Val Thr Val Trp Glu Leu 
225                 230                 235                 240 


Met Thr Phe Gly Ser Lys Pro Tyr Asp Gly Ile Pro Ala Ser Glu Ile 
                245                 250                 255     


Ser Ser Ile Leu Glu Lys Gly Glu Arg Leu Pro Gln Pro Pro Ile Cys 
            260                 265                 270         


Thr Ile Asp Val Tyr Met Ile Met Val Lys Cys Trp Met Ile Asp Ala 
        275                 280                 285             


Asp Ser Arg Pro Lys Phe Arg Glu Leu Ile Ile Glu Phe Ser Lys Met 
    290                 295                 300                 


Ala Arg Asp Pro Gln Arg Tyr Leu Val Ile Gln Gly Asp Glu Arg Met 
305                 310                 315                 320 


His Leu Pro Ser Pro Thr Asp Ser Asn Phe Tyr Arg Ala Leu Met Asp 
                325                 330                 335     


Glu Glu Asp Met Asp Asp Val Val Asp Ala Asp Glu Tyr Leu Ile Pro 
            340                 345                 350         


Gln Gln Gly Phe Phe Ser Ser Pro Ser Thr Ser Arg Thr Pro Leu Leu 
        355                 360                 365             


Ser Ser Leu Ser Ala Thr Ser Asn Asn Ser Thr Val Ala Cys Ile Asp 
    370                 375                 380                 


Arg Asn Gly Leu Gln Ser Cys Pro Ile Lys Glu Asp Ser Phe Leu Gln 
385                 390                 395                 400 


Arg Tyr Ser Ser Asp Pro Thr Gly Ala Leu Thr Glu Asp Ser Ile Asp 
                405                 410                 415     


Asp Thr Phe Leu Pro Val Pro Glu Tyr Ile Asn Gln Ser Val Pro Lys 
            420                 425                 430         


Arg Pro Ala Gly Ser Val Gln Asn Pro Val Tyr His Asn Gln Pro Leu 
        435                 440                 445             


Asn Pro Ala Pro Ser Arg Asp Pro His Tyr Gln Asp Pro His Ser Thr 
    450                 455                 460                 


Ala Val Gly Asn Pro Glu Tyr Leu Asn Thr Val Gln Pro Thr Cys Val 
465                 470                 475                 480 


Asn Ser Thr Phe Asp Ser Pro Ala His Trp Ala Gln Lys Gly Ser His 
                485                 490                 495     


Gln Ile Ser Leu Asp Asn Pro Asp Tyr Gln Gln Asp Phe Phe Pro Lys 
            500                 505                 510         


Glu Ala Lys Pro Asn Gly Ile Phe Lys Gly Ser Thr Ala Glu Asn Ala 
        515                 520                 525             


Glu Tyr Leu Arg Val Ala Pro Gln Ser Ser Glu Phe Ile Gly Ala 
    530                 535                 540             


<210>  736
<211>  1580
<212>  DNA
<213>  Homo sapiens

<400>  736
atcgctggga gcggttgcgg cgtgccggga gctgagttat agctgtgact tctgccctgc       60

caggccgcac acaagctggc tgacccggtt tgtaaaaatg gaatttcaag cagtagtgat      120

ggcagtaggt ggaggatctc ggatgacaga cctaacttcc agcattccca aacctctgct      180

tccagttggg aacaaacctt taatttggta cccattgaac ctgcttgagc gtgttggatt      240

tgaagaagtc attgtggtta caaccaggga tgttcaaaag gctctatgtg cagaattcaa      300

gatgaaaatg aagccagata ttgtgtgtat tcctgatgac gctgacatgg gaactgcaga      360

ttctttgcgc tacatatatc caaaacttaa gacagatgtg ctggtgctga gctgtgatct      420

gataacagac gttgccttac atgaggttgt ggacctgttt agagcttatg atgcatcact      480

tgctatgttg atgagaaaag gccaagatag catagaacct gttcccggtc aaaaggggaa      540

aaaaaaagca gtggagcagc gtgacttcat tggagtggac agcacaggaa agaggctgct      600

cttcatggct aatgaagcag acttggatga agagctggtc attaagggat ccatcctaca      660

gaagcatcct agaatacgtt tccacacggg tcttgtggat gcccacctct actgtttgaa      720

aaaatacatc gtggatttcc taatggaaaa tgggtcaata acttctatcc ggagtgaact      780

gattccatat ttagtgagaa aacagttttc ctcagcttcc tcacaacagg gacaagaaga      840

aaaagaggag gatctaaaga aaaaggagct gaagtcctta gatatctaca gttttataaa      900

agaagccaat acactgaacc tggctcccta tgatgcctgc tggaatgcct gtcgaggaga      960

caggtgggaa gacttgtcca gatcacaggt gcgctgctat gtccacatca tgaaagaggg     1020

gctctgctct cgagtgagca cactgggact ctacatggaa gcaaacagac aggtgcccaa     1080

attgctgtct gctctctgtc cagaagaacc accagtccat tcgtcagccc agattgtcag     1140

caaacacctg gttggagttg acagcctcat tgggccagag acacagattg gagagaagtc     1200

atccattaag cgctcagtca ttggctcatc ctgtctcata aaagatagag tgactattac     1260

caattgcctt ctcatgaact cagtcactgt ggaggaaggc taaacgagtg aatgaggtga     1320

tcgtggggaa tgaccagctc atggagatct gagttctgag caagtcagac tccttccttt     1380

tggcctccaa agccacagat gttggccggc ccacctgttt aactctgtat ttatttccca     1440

ataaagaagg gcttccaaag gcatgctgga gacttgtgga gcagtccaaa gctccatgtc     1500

aggtgggctc caggtgtaca cagtgtatgt tcatgtgtca tgtggtaaag atcatctgga     1560

gcaaaaaaaa aaaaaaaaaa                                                 1580


<210>  737
<211>  452
<212>  PRT
<213>  Homo sapiens

<400>  737

Met Glu Phe Gln Ala Val Val Met Ala Val Gly Gly Gly Ser Arg Met 
1               5                   10                  15      


Thr Asp Leu Thr Ser Ser Ile Pro Lys Pro Leu Leu Pro Val Gly Asn 
            20                  25                  30          


Lys Pro Leu Ile Trp Tyr Pro Leu Asn Leu Leu Glu Arg Val Gly Phe 
        35                  40                  45              


Glu Glu Val Ile Val Val Thr Thr Arg Asp Val Gln Lys Ala Leu Cys 
    50                  55                  60                  


Ala Glu Phe Lys Met Lys Met Lys Pro Asp Ile Val Cys Ile Pro Asp 
65                  70                  75                  80  


Asp Ala Asp Met Gly Thr Ala Asp Ser Leu Arg Tyr Ile Tyr Pro Lys 
                85                  90                  95      


Leu Lys Thr Asp Val Leu Val Leu Ser Cys Asp Leu Ile Thr Asp Val 
            100                 105                 110         


Ala Leu His Glu Val Val Asp Leu Phe Arg Ala Tyr Asp Ala Ser Leu 
        115                 120                 125             


Ala Met Leu Met Arg Lys Gly Gln Asp Ser Ile Glu Pro Val Pro Gly 
    130                 135                 140                 


Gln Lys Gly Lys Lys Lys Ala Val Glu Gln Arg Asp Phe Ile Gly Val 
145                 150                 155                 160 


Asp Ser Thr Gly Lys Arg Leu Leu Phe Met Ala Asn Glu Ala Asp Leu 
                165                 170                 175     


Asp Glu Glu Leu Val Ile Lys Gly Ser Ile Leu Gln Lys His Pro Arg 
            180                 185                 190         


Ile Arg Phe His Thr Gly Leu Val Asp Ala His Leu Tyr Cys Leu Lys 
        195                 200                 205             


Lys Tyr Ile Val Asp Phe Leu Met Glu Asn Gly Ser Ile Thr Ser Ile 
    210                 215                 220                 


Arg Ser Glu Leu Ile Pro Tyr Leu Val Arg Lys Gln Phe Ser Ser Ala 
225                 230                 235                 240 


Ser Ser Gln Gln Gly Gln Glu Glu Lys Glu Glu Asp Leu Lys Lys Lys 
                245                 250                 255     


Glu Leu Lys Ser Leu Asp Ile Tyr Ser Phe Ile Lys Glu Ala Asn Thr 
            260                 265                 270         


Leu Asn Leu Ala Pro Tyr Asp Ala Cys Trp Asn Ala Cys Arg Gly Asp 
        275                 280                 285             


Arg Trp Glu Asp Leu Ser Arg Ser Gln Val Arg Cys Tyr Val His Ile 
    290                 295                 300                 


Met Lys Glu Gly Leu Cys Ser Arg Val Ser Thr Leu Gly Leu Tyr Met 
305                 310                 315                 320 


Glu Ala Asn Arg Gln Val Pro Lys Leu Leu Ser Ala Leu Cys Pro Glu 
                325                 330                 335     


Glu Pro Pro Val His Ser Ser Ala Gln Ile Val Ser Lys His Leu Val 
            340                 345                 350         


Gly Val Asp Ser Leu Ile Gly Pro Glu Thr Gln Ile Gly Glu Lys Ser 
        355                 360                 365             


Ser Ile Lys Arg Ser Val Ile Gly Ser Ser Cys Leu Ile Lys Asp Arg 
    370                 375                 380                 


Val Thr Ile Thr Asn Cys Leu Leu Met Asn Ser Val Thr Val Glu Glu 
385                 390                 395                 400 


Gly Ser Asn Ile Gln Gly Ser Val Ile Cys Asn Asn Ala Val Ile Glu 
                405                 410                 415     


Lys Gly Ala Asp Ile Lys Asp Cys Leu Ile Gly Ser Gly Gln Arg Ile 
            420                 425                 430         


Glu Ala Lys Ala Lys Arg Val Asn Glu Val Ile Val Gly Asn Asp Gln 
        435                 440                 445             


Leu Met Glu Ile 
    450         


<210>  738
<211>  401
<212>  PRT
<213>  Homo sapiens

<400>  738

Met Glu Phe Gln Ala Val Val Met Ala Val Gly Gly Gly Ser Arg Met 
1               5                   10                  15      


Thr Asp Leu Thr Ser Ser Ile Pro Lys Pro Leu Leu Pro Val Gly Asn 
            20                  25                  30          


Lys Pro Leu Ile Trp Tyr Pro Leu Asn Leu Leu Glu Arg Val Gly Phe 
        35                  40                  45              


Glu Glu Val Ile Val Val Thr Thr Arg Asp Val Gln Lys Ala Leu Cys 
    50                  55                  60                  


Ala Glu Phe Lys Met Lys Met Lys Pro Asp Ile Val Cys Ile Pro Asp 
65                  70                  75                  80  


Asp Ala Asp Met Gly Thr Ala Asp Ser Leu Arg Tyr Ile Tyr Pro Lys 
                85                  90                  95      


Leu Lys Thr Asp Val Leu Val Leu Ser Cys Asp Leu Ile Thr Asp Val 
            100                 105                 110         


Ala Leu His Glu Val Val Asp Leu Phe Arg Ala Tyr Asp Ala Ser Leu 
        115                 120                 125             


Ala Met Leu Met Arg Lys Gly Gln Asp Ser Ile Glu Pro Val Pro Gly 
    130                 135                 140                 


Gln Lys Gly Lys Lys Lys Ala Val Glu Gln Arg Asp Phe Ile Gly Val 
145                 150                 155                 160 


Asp Ser Thr Gly Lys Arg Leu Leu Phe Met Ala Asn Glu Ala Asp Leu 
                165                 170                 175     


Asp Glu Glu Leu Val Ile Lys Gly Ser Ile Leu Gln Lys His Pro Arg 
            180                 185                 190         


Ile Arg Phe His Thr Gly Leu Val Asp Ala His Leu Tyr Cys Leu Lys 
        195                 200                 205             


Lys Tyr Ile Val Asp Phe Leu Met Glu Asn Gly Ser Ile Thr Ser Ile 
    210                 215                 220                 


Arg Ser Glu Leu Ile Pro Tyr Leu Val Arg Lys Gln Phe Ser Ser Ala 
225                 230                 235                 240 


Ser Ser Gln Gln Gly Gln Glu Glu Lys Glu Glu Asp Leu Lys Lys Lys 
                245                 250                 255     


Glu Leu Lys Ser Leu Asp Ile Tyr Ser Phe Ile Lys Glu Ala Asn Thr 
            260                 265                 270         


Leu Asn Leu Ala Pro Tyr Asp Ala Cys Trp Asn Ala Cys Arg Gly Asp 
        275                 280                 285             


Arg Trp Glu Asp Leu Ser Arg Ser Gln Val Arg Cys Tyr Val His Ile 
    290                 295                 300                 


Met Lys Glu Gly Leu Cys Ser Arg Val Ser Thr Leu Gly Leu Tyr Met 
305                 310                 315                 320 


Glu Ala Asn Arg Gln Val Pro Lys Leu Leu Ser Ala Leu Cys Pro Glu 
                325                 330                 335     


Glu Pro Pro Val His Ser Ser Ala Gln Ile Val Ser Lys His Leu Val 
            340                 345                 350         


Gly Val Asp Ser Leu Ile Gly Pro Glu Thr Gln Ile Gly Glu Lys Ser 
        355                 360                 365             


Ser Ile Lys Arg Ser Val Ile Gly Ser Ser Cys Leu Ile Lys Asp Arg 
    370                 375                 380                 


Val Thr Ile Thr Asn Cys Leu Leu Met Asn Ser Val Thr Val Glu Glu 
385                 390                 395                 400 


Gly 
    


<210>  739
<211>  979
<212>  DNA
<213>  Homo sapiens

<400>  739
cttacagaac tcccacggac acaccatgat aaggacgctg ctgctgtcca ctttggtggc       60

tggagccctc agttgtgggg accccactta cccaccttat gtgactaggg tggttggcgg      120

tgaagaagcg aggcccaaca gctggccctg gcaggtctcc ctgcagtaca gctccaatgg      180

caagtggtac cacacctgcg gagggtccct gatagccaac agctgggtcc tgacggctgc      240

ccactgcatc agctcctcca ggacctaccg cgtggggctg ggccggcaca acctctacgt      300

tgcggagtcc ggctcgctgg cagtcagtgt ctctaagatt gtggtgcaca aggactggaa      360

ctccaaccaa atctccaaag ggaacgacat tgccctgctc aaactggcta accccgtctc      420

cctcaccgac aagatccagc tggcctgcct ccctcctgcc ggcaccattc tacccaacaa      480

ctacccctgc tacgtcacgg gctggggaag gctgcagacc aacggggctg ttcctgatgt      540

cctgcagcag ggccggttgc tggttgtgga ctatgccacc tgctccagct ctgcctggtg      600

gggcagcagc gtgaaaacca gtatgatctg tgctgggggt gatggcgtga tctccagctg      660

caacggagac tctggcgggc cactgaactg tcaggcgtct gacggccggt ggcaggtgca      720

cggcatcgtc agcttcgggt ctcgcctcgg ctgcaactac taccacaagc cctccgtctt      780

cacgcgggtc tccaattaca tcgactggat caattcggtg attgcaaata actaaccaaa      840

agaagtccct gggactgttt cagacttgga aaggtcacag aaggaaaata atataataaa      900

gtgacaacta tgcaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaata aaaaaaaaaa      960

aaaaaaaaaa aaaaaaaaa                                                   979


<210>  740
<211>  269
<212>  PRT
<213>  Homo sapiens

<400>  740

Met Ile Arg Thr Leu Leu Leu Ser Thr Leu Val Ala Gly Ala Leu Ser 
1               5                   10                  15      


Cys Gly Asp Pro Thr Tyr Pro Pro Tyr Val Thr Arg Val Val Gly Gly 
            20                  25                  30          


Glu Glu Ala Arg Pro Asn Ser Trp Pro Trp Gln Val Ser Leu Gln Tyr 
        35                  40                  45              


Ser Ser Asn Gly Lys Trp Tyr His Thr Cys Gly Gly Ser Leu Ile Ala 
    50                  55                  60                  


Asn Ser Trp Val Leu Thr Ala Ala His Cys Ile Ser Ser Ser Arg Thr 
65                  70                  75                  80  


Tyr Arg Val Gly Leu Gly Arg His Asn Leu Tyr Val Ala Glu Ser Gly 
                85                  90                  95      


Ser Leu Ala Val Ser Val Ser Lys Ile Val Val His Lys Asp Trp Asn 
            100                 105                 110         


Ser Asn Gln Ile Ser Lys Gly Asn Asp Ile Ala Leu Leu Lys Leu Ala 
        115                 120                 125             


Asn Pro Val Ser Leu Thr Asp Lys Ile Gln Leu Ala Cys Leu Pro Pro 
    130                 135                 140                 


Ala Gly Thr Ile Leu Pro Asn Asn Tyr Pro Cys Tyr Val Thr Gly Trp 
145                 150                 155                 160 


Gly Arg Leu Gln Thr Asn Gly Ala Val Pro Asp Val Leu Gln Gln Gly 
                165                 170                 175     


Arg Leu Leu Val Val Asp Tyr Ala Thr Cys Ser Ser Ser Ala Trp Trp 
            180                 185                 190         


Gly Ser Ser Val Lys Thr Ser Met Ile Cys Ala Gly Gly Asp Gly Val 
        195                 200                 205             


Ile Ser Ser Cys Asn Gly Asp Ser Gly Gly Pro Leu Asn Cys Gln Ala 
    210                 215                 220                 


Ser Asp Gly Arg Trp Gln Val His Gly Ile Val Ser Phe Gly Ser Arg 
225                 230                 235                 240 


Leu Gly Cys Asn Tyr Tyr His Lys Pro Ser Val Phe Thr Arg Val Ser 
                245                 250                 255     


Asn Tyr Ile Asp Trp Ile Asn Ser Val Ile Ala Asn Asn 
            260                 265                 


<210>  741
<211>  269
<212>  PRT
<213>  Homo sapiens

<400>  741

Met Ile Arg Thr Leu Leu Leu Ser Thr Leu Val Ala Gly Ala Leu Ser 
1               5                   10                  15      


Cys Gly Asp Pro Thr Tyr Pro Pro Tyr Val Thr Arg Val Val Gly Gly 
            20                  25                  30          


Glu Glu Ala Arg Pro Asn Ser Trp Pro Trp Gln Val Ser Leu Gln Tyr 
        35                  40                  45              


Ser Ser Asn Gly Lys Trp Tyr His Thr Cys Gly Gly Ser Leu Ile Ala 
    50                  55                  60                  


Asn Ser Trp Val Leu Thr Ala Ala His Cys Ile Ser Ser Ser Arg Thr 
65                  70                  75                  80  


Tyr Arg Val Gly Leu Gly Arg His Asn Leu Tyr Val Ala Glu Ser Gly 
                85                  90                  95      


Ser Leu Ala Val Ser Val Ser Lys Ile Val Val His Lys Asp Trp Asn 
            100                 105                 110         


Ser Asn Gln Ile Ser Lys Gly Asn Asp Ile Ala Leu Leu Lys Leu Ala 
        115                 120                 125             


Asn Pro Val Ser Leu Thr Asp Lys Ile Gln Leu Ala Cys Leu Pro Pro 
    130                 135                 140                 


Ala Gly Thr Ile Leu Pro Asn Asn Tyr Pro Cys Tyr Val Thr Gly Trp 
145                 150                 155                 160 


Gly Arg Leu Gln Thr Asn Gly Ala Val Pro Asp Val Leu Gln Gln Gly 
                165                 170                 175     


Arg Leu Leu Val Val Asp Tyr Ala Thr Cys Ser Ser Ser Ala Trp Trp 
            180                 185                 190         


Gly Ser Ser Val Lys Thr Ser Met Ile Cys Ala Gly Gly Asp Gly Val 
        195                 200                 205             


Ile Ser Ser Cys Asn Gly Asp Ser Gly Gly Pro Leu Asn Cys Gln Ala 
    210                 215                 220                 


Ser Asp Gly Arg Trp Gln Val His Gly Ile Val Ser Phe Gly Ser Arg 
225                 230                 235                 240 


Leu Gly Cys Asn Tyr Tyr His Lys Pro Ser Val Phe Thr Arg Val Ser 
                245                 250                 255     


Asn Tyr Ile Asp Trp Ile Asn Ser Val Ile Ala Asn Asn 
            260                 265                 


<210>  742
<211>  3029
<212>  DNA
<213>  Homo sapiens

<400>  742
ccgcagagag gtgtggtcag ggacatttcc cctggccggg agcccatgga gcactgtcct       60

cagagatgcg caggttaggc tcactgtcta ggccaggccc accttagtca ctgtggactg      120

gcaatggaag ctcttcctgg acacacctgc cctagccctc accctggggt ggaagagaaa      180

tgagcttggc ttgcaactca gaccattcca cggaggcatc ctccccttcc tgggctggtg      240

aataaaagtt tcctgaggtc aaggacttcc ttttccctgc caaaatggtg tccagaactt      300

tgaggccaga ggtgatccag tgatttggga gctgcaggtc acacaggctg ctcagagggc      360

tgctgaacag gatgtcctcg gacgacaggc acctgggctc cagctgcggc tccttcatca      420

agactgagcc gtccagcccg tcctcgggca tcgatgccct cagccaccac agccccagtg      480

gctcgtccga cgccagcggc ggctttggcc tggccctggg cacccacgcc aacggtctgg      540

actcgccacc catgtttgca ggcgccgggc tgggaggcac cccatgccgc aagagctacg      600

aggactgtgc cagcggcatc atggaggact cggccatcaa gtgcgagtac atgctcaacg      660

ccatccccaa gcgcctgtgc ctcgtgtgcg gggacattgc ctctggctac cactacggcg      720

tggcctcctg cgaggcttgc aaggccttct tcaagaggac tatccaaggg aacattgagt      780

acagctgccc ggccaccaac gagtgcgaga tcaccaaacg gaggcgcaag tcctgccagg      840

cctgccgctt catgaaatgc ctcaaagtgg ggatgctgaa ggaaggtgtg cgccttgatc      900

gagtgcgtgg aggccgtcag aaatacaagc gacggctgga ctcagagagc agcccatacc      960

tgagcttaca aatttctcca cctgctaaaa agccattgac caagattgtc tcatacctac     1020

tggtggctga gccggacaag ctctatgcca tgcctccccc tggtatgcct gagggggaca     1080

tcaaggccct gaccactctc tgtgacctgg cagaccgaga gcttgtggtc atcattggct     1140

gggccaagca catcccaggc ttctcaagcc tctccctggg ggaccagatg agcctgctgc     1200

agagtgcctg gatggaaatc ctcatcctgg gcatcgtgta ccgctcgctg ccctatgacg     1260

acaagctggt gtacgctgag gactacatca tggatgagga gcactcccgc ctcgcggggc     1320

tgctggagct ctaccgggcc atcctgcagc tggtacgcag gtacaagaag ctcaaggtgg     1380

agaaggagga gtttgtgacg ctcaaggccc tggccctcgc caactccgat tccatgtaca     1440

tcgaggatct agaggctgtc cagaagctgc aggacctgct gcacgaggca ctgcaggact     1500

acgagctgag ccagcgccat gaggagccct ggaggacggg caagctgctg ctgacactgc     1560

cgctgctgcg gcagacggcc gccaaggccg tgcagcactt ctatagcgtc aaactgcagg     1620

gcaaagtgcc catgcacaaa ctcttcctgg agatgctgga ggccaaggtt ggccaagagc     1680

agcttagagg atctcccaag gatgaaagaa tgtcaagcca tgatggaaaa tgccccttcc     1740

aatcagctgc cttcacaagc agggatcaga gcaactcccc ggggatcccc aatccacgcc     1800

cttctagtcc aacccccctc aatgagagag gcaggcagat ctcacccagc actaggacac     1860

caggaggcca gggaaagcat ctctggctca ccatgtaaca tctggcttgg agcaagtggg     1920

tgttctgcac accaggcagc tgcacctcac tggatctagt gttgctgcga gtgacctcac     1980

ttcagagccc ctctagcaga gtggggcgga agtcctgatg gttggtgtcc atgaggtgga     2040

agctgctttt atacttaaaa ctcagatcac aacaggaaat gtgtcagtaa caatggaact     2100

ccatccaatg ggaaagttcc tggtactgaa ggggtccatt ggacactcag aaaagaagtt     2160

caggggccaa cttcttagct ggaatcctgg ccagatgagg accctctccg gggaagggag     2220

aggactgact tagtggaagg tggtgaagtg aggagagttt aggggaacct tcccccagtg     2280

gaacagatct caagtttacc ctaaacctgc catttctgga aaatctgtaa agaggaaaca     2340

gcctgtctca gctgtactct catgatacag gtcatttgaa atgaaccaag aaataaaaca     2400

tgaaaatcca accatggaga aggtggtatg gctgggtttt gtttggtccc cttgtcctta     2460

tacgttctaa agtttccaga ctggctttgt cactttgtga actcgtcatg tgtgaaaacc     2520

aatctttgca tatagggaac ttcctcgggc cacactttaa gaaccaagta agaggctctc     2580

aagactccag cagagtcggg aggccatggc agcgccttag aggagctgga acctgcaccc     2640

acctgtgtcg gtgggggggg cctcctttcc ccatagactc tgccctccct ctgtgcagat     2700

ggaagtggca ggggagggtg accagcttgt gacaagaaga ctgaagggtc cagagtccat     2760

gctcacggaa cagcaccaaa gaaaagcact atgtggaaag attgttttat tttctaataa     2820

tgataatatg gctggaatgg cttcttaaga tgtatatatt ttttaaaatg gcagttcccc     2880

attgcagcat cacctacttg tatgtctttc tgcctctgta tatgttctcc cagaaacccc     2940

catgtaaatc aaatgcccta ggatgcttcc atcctggtcc catgtatctg gaatctaata     3000

aataaggaaa ggaaaaaaaa aaaaaaaaa                                       3029


<210>  743
<211>  500
<212>  PRT
<213>  Homo sapiens

<400>  743

Met Ser Ser Asp Asp Arg His Leu Gly Ser Ser Cys Gly Ser Phe Ile 
1               5                   10                  15      


Lys Thr Glu Pro Ser Ser Pro Ser Ser Gly Ile Asp Ala Leu Ser His 
            20                  25                  30          


His Ser Pro Ser Gly Ser Ser Asp Ala Ser Gly Gly Phe Gly Leu Ala 
        35                  40                  45              


Leu Gly Thr His Ala Asn Gly Leu Asp Ser Pro Pro Met Phe Ala Gly 
    50                  55                  60                  


Ala Gly Leu Gly Gly Thr Pro Cys Arg Lys Ser Tyr Glu Asp Cys Ala 
65                  70                  75                  80  


Ser Gly Ile Met Glu Asp Ser Ala Ile Lys Cys Glu Tyr Met Leu Asn 
                85                  90                  95      


Ala Ile Pro Lys Arg Leu Cys Leu Val Cys Gly Asp Ile Ala Ser Gly 
            100                 105                 110         


Tyr His Tyr Gly Val Ala Ser Cys Glu Ala Cys Lys Ala Phe Phe Lys 
        115                 120                 125             


Arg Thr Ile Gln Gly Asn Ile Glu Tyr Ser Cys Pro Ala Thr Asn Glu 
    130                 135                 140                 


Cys Glu Ile Thr Lys Arg Arg Arg Lys Ser Cys Gln Ala Cys Arg Phe 
145                 150                 155                 160 


Met Lys Cys Leu Lys Val Gly Met Leu Lys Glu Gly Val Arg Leu Asp 
                165                 170                 175     


Arg Val Arg Gly Gly Arg Gln Lys Tyr Lys Arg Arg Leu Asp Ser Glu 
            180                 185                 190         


Ser Ser Pro Tyr Leu Ser Leu Gln Ile Ser Pro Pro Ala Lys Lys Pro 
        195                 200                 205             


Leu Thr Lys Ile Val Ser Tyr Leu Leu Val Ala Glu Pro Asp Lys Leu 
    210                 215                 220                 


Tyr Ala Met Pro Pro Pro Gly Met Pro Glu Gly Asp Ile Lys Ala Leu 
225                 230                 235                 240 


Thr Thr Leu Cys Asp Leu Ala Asp Arg Glu Leu Val Val Ile Ile Gly 
                245                 250                 255     


Trp Ala Lys His Ile Pro Gly Phe Ser Ser Leu Ser Leu Gly Asp Gln 
            260                 265                 270         


Met Ser Leu Leu Gln Ser Ala Trp Met Glu Ile Leu Ile Leu Gly Ile 
        275                 280                 285             


Val Tyr Arg Ser Leu Pro Tyr Asp Asp Lys Leu Val Tyr Ala Glu Asp 
    290                 295                 300                 


Tyr Ile Met Asp Glu Glu His Ser Arg Leu Ala Gly Leu Leu Glu Leu 
305                 310                 315                 320 


Tyr Arg Ala Ile Leu Gln Leu Val Arg Arg Tyr Lys Lys Leu Lys Val 
                325                 330                 335     


Glu Lys Glu Glu Phe Val Thr Leu Lys Ala Leu Ala Leu Ala Asn Ser 
            340                 345                 350         


Asp Ser Met Tyr Ile Glu Asp Leu Glu Ala Val Gln Lys Leu Gln Asp 
        355                 360                 365             


Leu Leu His Glu Ala Leu Gln Asp Tyr Glu Leu Ser Gln Arg His Glu 
    370                 375                 380                 


Glu Pro Trp Arg Thr Gly Lys Leu Leu Leu Thr Leu Pro Leu Leu Arg 
385                 390                 395                 400 


Gln Thr Ala Ala Lys Ala Val Gln His Phe Tyr Ser Val Lys Leu Gln 
                405                 410                 415     


Gly Lys Val Pro Met His Lys Leu Phe Leu Glu Met Leu Glu Ala Lys 
            420                 425                 430         


Ala Trp Ala Arg Ala Asp Ser Leu Gln Glu Trp Arg Pro Leu Glu Gln 
        435                 440                 445             


Val Pro Ser Pro Leu His Arg Ala Thr Lys Arg Gln His Val His Phe 
    450                 455                 460                 


Leu Thr Pro Leu Pro Pro Pro Pro Ser Val Ala Trp Val Gly Thr Ala 
465                 470                 475                 480 


Gln Ala Gly Tyr His Leu Glu Val Phe Leu Pro Gln Arg Ala Gly Trp 
                485                 490                 495     


Pro Arg Ala Ala 
            500 


<210>  744
<211>  241
<212>  PRT
<213>  Homo sapiens

<400>  744

Lys Lys Ala Gly Ser Ala Ala Ala Pro Phe Thr Pro Ala Lys Lys Pro 
1               5                   10                  15      


Leu Thr Lys Ile Val Ser Tyr Leu Leu Val Ala Glu Pro Asp Lys Leu 
            20                  25                  30          


Tyr Ala Met Pro Pro Pro Gly Met Pro Glu Gly Asp Ile Lys Ala Leu 
        35                  40                  45              


Thr Thr Leu Cys Asp Leu Ala Asp Arg Glu Leu Val Val Ile Ile Gly 
    50                  55                  60                  


Trp Ala Lys His Ile Pro Gly Phe Ser Ser Leu Ser Leu Gly Asp Gln 
65                  70                  75                  80  


Met Ser Leu Leu Gln Ser Ala Trp Met Glu Ile Leu Ile Leu Gly Ile 
                85                  90                  95      


Val Tyr Arg Ser Leu Pro Tyr Asp Asp Lys Leu Val Tyr Ala Glu Asp 
            100                 105                 110         


Tyr Ile Met Asp Glu Glu His Ser Arg Leu Ala Gly Leu Leu Glu Leu 
        115                 120                 125             


Tyr Arg Ala Ile Leu Gln Leu Val Arg Arg Tyr Lys Lys Leu Lys Val 
    130                 135                 140                 


Glu Lys Glu Glu Phe Val Thr Leu Lys Ala Leu Ala Leu Ala Asn Ser 
145                 150                 155                 160 


Asp Ser Met Tyr Ile Glu Asp Leu Glu Ala Val Gln Lys Leu Gln Asp 
                165                 170                 175     


Leu Leu His Glu Ala Leu Gln Asp Tyr Glu Leu Ser Gln Arg His Glu 
            180                 185                 190         


Glu Pro Trp Arg Thr Gly Lys Leu Leu Leu Thr Leu Pro Leu Leu Arg 
        195                 200                 205             


Gln Thr Ala Ala Lys Ala Val Gln His Phe Tyr Ser Val Lys Leu Gln 
    210                 215                 220                 


Gly Lys Val Pro Met His Lys Leu Phe Leu Glu Met Leu Glu Ala Lys 
225                 230                 235                 240 


Val 
    


<210>  745
<211>  1948
<212>  DNA
<213>  Homo sapiens

<400>  745
ggtacttcat caatttttct tttcttttta tggactcttt tctgttggca aaaaaaacct       60

gttatttctt gatcttttgg caccattttc gcacttaata atggcgtaat ttctcttcta      120

tttgttttct atttgcccat ctgttctttt ttctcctttt cctgccttct tttggaccaa      180

aaacgaaaac caagaaatgc cttattccac aaacaaagag ttgatacttg gcatcatggt      240

gggcactgct ggaatcagct tgctgctctt gtggtaccac aaggtccgta aaccagggat      300

agcaatgaag ttacctgaat ttctttctct gggtaataca tttaattcaa taactttgca      360

agatgaaata catgatgacc aaggaacaac agtaatcttt caagaaaggc aacttcagat      420

actggagaag ttaaacgaat tactgacaaa tatggaagaa ctcaaagagg aaatcagatt      480

tcttaaagaa gctattccaa agctggagga atatatacaa gatgaacttg gagggaaaat      540

aactgttcat aagataagcc ctcagcacag agcgagaaaa agaagactcc ccacaattca      600

aagttcagca acaagtaata gttcagagga agcagaaagt gaaggagggt atattacagc      660

taatactgac acagaagaac agagttttcc agtccctaag gcatttaaca cacgtgtaga      720

ggaattaaat ttagatgtcc ttcttcagaa ggtagatcat ttacgtatga gtgagtctgg      780

caagtcggag agttttgaac tacttcgtga ccacaaagaa aagtttagag atgaaataga      840

gtttatgtgg cgatttgctc gtgcttatgg agacatgtat gaactatcta caaacacaca      900

agaaaagaaa cattatgcta atattggaaa aactttaagt gaaagagcta ttaatagagc      960

acccatgaat ggacattgtc atctgtggta tgcagttttg tgtggctatg tatctgagtt     1020

tgagggttta caaaacaaaa tcaactatgg gcacctcttc aaggaacatc tagatatagc     1080

aatcaaactt ttaccagagg aaccctttct atattacctc aaagggagat actgctatac     1140

tgtctcaaaa ctgagctgga ttgagaaaaa aatggctgct actctgtttg gaaaaatacc     1200

atcttcaact gtacaagaag ctttacacaa tttccttaag gctgaagaac tatgccctgg     1260

ttattctaat cccaattaca tgtacttagc aaagtgttat actgatcttg aggaaaacca     1320

gaatgctttg aagttctgta atttggcttt attgcttcct actgttacca aagaggataa     1380

agaggcacag aaagagatgc aaaaaataat gacttccttg aagaggtaaa taaacgaatt     1440

tactcttcaa caaatcagat gtggtctacc aaaatttaaa tgaatcaaag ttgtgctttt     1500

attatccttc atttttgatg taagggtatt gtgcttagat ttgaaggtaa agccatgttt     1560

ctgcagaatg cattccacta gtagcactac aaaattaatt atgttatttg gagaatctat     1620

atactataat gtcaatacat aatctataaa catgtatgct ttatattttt cttatcaata     1680

aactgcagcc ttaagaatat ttctttaaat aaaatattta aatccaataa aatgaattct     1740

catgaatatt ttattgtttc aatggagact tcgtaagaca aaataatttc attaatgtgg     1800

atgaaaaatg gaaaactcag caaaggacat gaacaagttg ttggcagaag aggaaaaaca     1860

aacaaatgta gtattgtaac tggtaatcaa aagatgtgaa taaaattaca ataaaatact     1920

gttttaccat cgaaaaaaaa aaaaaaaa                                        1948


<210>  746
<211>  410
<212>  PRT
<213>  Homo sapiens

<400>  746

Met Pro Tyr Ser Thr Asn Lys Glu Leu Ile Leu Gly Ile Met Val Gly 
1               5                   10                  15      


Thr Ala Gly Ile Ser Leu Leu Leu Leu Trp Tyr His Lys Val Arg Lys 
            20                  25                  30          


Pro Gly Ile Ala Met Lys Leu Pro Glu Phe Leu Ser Leu Gly Asn Thr 
        35                  40                  45              


Phe Asn Ser Ile Thr Leu Gln Asp Glu Ile His Asp Asp Gln Gly Thr 
    50                  55                  60                  


Thr Val Ile Phe Gln Glu Arg Gln Leu Gln Ile Leu Glu Lys Leu Asn 
65                  70                  75                  80  


Glu Leu Leu Thr Asn Met Glu Glu Leu Lys Glu Glu Ile Arg Phe Leu 
                85                  90                  95      


Lys Glu Ala Ile Pro Lys Leu Glu Glu Tyr Ile Gln Asp Glu Leu Gly 
            100                 105                 110         


Gly Lys Ile Thr Val His Lys Ile Ser Pro Gln His Arg Ala Arg Lys 
        115                 120                 125             


Arg Arg Leu Pro Thr Ile Gln Ser Ser Ala Thr Ser Asn Ser Ser Glu 
    130                 135                 140                 


Glu Ala Glu Ser Glu Gly Gly Tyr Ile Thr Ala Asn Thr Asp Thr Glu 
145                 150                 155                 160 


Glu Gln Ser Phe Pro Val Pro Lys Ala Phe Asn Thr Arg Val Glu Glu 
                165                 170                 175     


Leu Asn Leu Asp Val Leu Leu Gln Lys Val Asp His Leu Arg Met Ser 
            180                 185                 190         


Glu Ser Gly Lys Ser Glu Ser Phe Glu Leu Leu Arg Asp His Lys Glu 
        195                 200                 205             


Lys Phe Arg Asp Glu Ile Glu Phe Met Trp Arg Phe Ala Arg Ala Tyr 
    210                 215                 220                 


Gly Asp Met Tyr Glu Leu Ser Thr Asn Thr Gln Glu Lys Lys His Tyr 
225                 230                 235                 240 


Ala Asn Ile Gly Lys Thr Leu Ser Glu Arg Ala Ile Asn Arg Ala Pro 
                245                 250                 255     


Met Asn Gly His Cys His Leu Trp Tyr Ala Val Leu Cys Gly Tyr Val 
            260                 265                 270         


Ser Glu Phe Glu Gly Leu Gln Asn Lys Ile Asn Tyr Gly His Leu Phe 
        275                 280                 285             


Lys Glu His Leu Asp Ile Ala Ile Lys Leu Leu Pro Glu Glu Pro Phe 
    290                 295                 300                 


Leu Tyr Tyr Leu Lys Gly Arg Tyr Cys Tyr Thr Val Ser Lys Leu Ser 
305                 310                 315                 320 


Trp Ile Glu Lys Lys Met Ala Ala Thr Leu Phe Gly Lys Ile Pro Ser 
                325                 330                 335     


Ser Thr Val Gln Glu Ala Leu His Asn Phe Leu Lys Ala Glu Glu Leu 
            340                 345                 350         


Cys Pro Gly Tyr Ser Asn Pro Asn Tyr Met Tyr Leu Ala Lys Cys Tyr 
        355                 360                 365             


Thr Asp Leu Glu Glu Asn Gln Asn Ala Leu Lys Phe Cys Asn Leu Ala 
    370                 375                 380                 


Leu Leu Leu Pro Thr Val Thr Lys Glu Asp Lys Glu Ala Gln Lys Glu 
385                 390                 395                 400 


Met Gln Lys Ile Met Thr Ser Leu Lys Arg 
                405                 410 


<210>  747
<211>  220
<212>  PRT
<213>  Homo sapiens

<400>  747

Met Ser Glu Ser Gly Lys Ser Glu Ser Phe Glu Leu Leu Arg Asp His 
1               5                   10                  15      


Lys Glu Lys Phe Arg Asp Glu Ile Glu Phe Met Trp Arg Phe Ala Arg 
            20                  25                  30          


Ala Tyr Gly Asp Met Tyr Glu Leu Ser Thr Asn Thr Gln Glu Lys Lys 
        35                  40                  45              


His Tyr Ala Asn Ile Gly Lys Thr Leu Ser Glu Arg Ala Ile Asn Arg 
    50                  55                  60                  


Ala Pro Met Asn Gly His Cys His Leu Trp Tyr Ala Val Leu Cys Gly 
65                  70                  75                  80  


Tyr Val Ser Glu Phe Glu Gly Leu Gln Asn Lys Ile Asn Tyr Gly His 
                85                  90                  95      


Leu Phe Lys Glu His Leu Asp Ile Ala Ile Lys Leu Leu Pro Glu Glu 
            100                 105                 110         


Pro Phe Leu Tyr Tyr Leu Lys Gly Arg Tyr Cys Tyr Thr Val Ser Lys 
        115                 120                 125             


Leu Ser Trp Ile Glu Lys Lys Met Ala Ala Thr Leu Phe Gly Lys Ile 
    130                 135                 140                 


Pro Ser Ser Thr Val Gln Glu Ala Leu His Asn Phe Leu Lys Ala Glu 
145                 150                 155                 160 


Glu Leu Cys Pro Gly Tyr Ser Asn Pro Asn Tyr Met Tyr Leu Ala Lys 
                165                 170                 175     


Cys Tyr Thr Asp Leu Glu Glu Asn Gln Asn Ala Leu Lys Phe Cys Asn 
            180                 185                 190         


Leu Ala Leu Leu Leu Pro Thr Val Thr Lys Glu Asp Lys Glu Ala Gln 
        195                 200                 205             


Lys Glu Met Gln Lys Ile Met Thr Ser Leu Lys Arg 
    210                 215                 220 


<210>  748
<211>  2423
<212>  DNA
<213>  Homo sapiens

<400>  748
gagagccgag ctagcgacga gcagtcgttg cggccgccgg cgccgcggga ggtggtggag       60

gcctagccgg agccgagagg tctcttgttc ccgtcccacg gtcccggcgt cacccctccg      120

gcgcccagtc cccgtcccgg aactcccggg cctgtcctgg gcccccggtc tgtgcactcc      180

gctcgccgca gcgcccggcc cgggccgcac ccgccggccc catgaggagg gacgtgaacg      240

gagtgaccaa gagcaggttt gagatgttct caaatagtga tgaagctgta atcaataaaa      300

aacttcccaa agaactcctg ttacggatat tttcttttct agatgttgtt accctgtgcc      360

gctgtgctca ggtctccagg gcctggaatg ttctggctct ggatggcagt aactggcagc      420

gaattgacct atttgatttc cagagggata ttgagggccg agtagtggag aatatttcaa      480

aacgatgtgg gggcttttta cgaaagttaa gtcttcgtgg atgtcttgga gtgggagaca      540

atgcattaag aacctttgca caaaactgca ggaacattga agtactgaat ctaaatgggt      600

gtacaaagac aacagacgct acatgtacta gccttagcaa gttctgttcc aaactcaggc      660

accttgactt ggcttcctgt acatcaataa caaacatgtc tctaaaagct ctgagtgagg      720

gatgtccact gttggagcag ttgaacattt cctggtgtga ccaagtaacc aaggatggca      780

ttcaagcact agtgaggggc tgtgggggtc tcaaggcctt attcttaaaa ggctgcacgc      840

agctagaaga tgaagctctc aagtacatag gtgcacactg ccctgaactg gtgactttga      900

acttgcagac ttgcttgcaa atcacagatg aaggtctcat tactatatgc agagggtgcc      960

ataagttaca atccctttgt gcctctggct gctccaacat cacagatgcc atcctgaatg     1020

ctctaggtca gaactgccca cggcttagaa tattggaagt ggcaagatgt tctcaattaa     1080

cagatgtggg ctttaccact ctagccagga attgccatga acttgaaaag atggacctgg     1140

aagagtgtgt tcagataaca gatagcacat taatccaact ttctatacac tgtcctcgac     1200

ttcaagtatt gagtctgtct cactgtgagc tgatcacaga tgatggaatt cgtcacctgg     1260

ggaatggggc ctgcgcccat gaccagctgg aggtgattga gctggacaac tgcccactaa     1320

tcacagatgc atccctggag cacttgaaga gctgtcatag ccttgagcgg atagaactct     1380

atgactgcca gcaaatcaca cgggctggaa tcaagagact caggacccat ttacccaata     1440

ttaaagtcca cgcctacttc gcacctgtca ctccaccccc atcagtaggg ggcagcagac     1500

agcgcttctg cagatgctgc atcatcctat gacaatggag gtggtcaacc ttggcgaact     1560

gagtatttaa tgacacttct agagctaccg tggagtctct ccagtggaag caaccccagt     1620

gttctgagca agggttacaa agtgagggag ggcagtgtcc agatccccag agccacacat     1680

acatacacat acacaccctt acccccatcc actctagctt tgtgaccatg ggactgaagt     1740

ttgtgatggc ttttttatca agtagattgg taaaatttaa ccattcctgt tgaggtgccc     1800

ataagaaaat cataggccaa gatagggagg ggcattccag caaaccccgt gttaatgcta     1860

ctgtggtttt taaatttttg tctaggggtt tctttgggga ttttagaaca gcatctgctg     1920

tcctccgggg tcaagaaaag catggaaaga caatatatga tgtacccagg gaccagaaag     1980

aaaatttctt tgcatcttag aaatggtaga cattcattgt gactaaagag cttctatgct     2040

tccttgtttc catgccaaca tgctgagcat gctcacaaag aaggctcgtc cattcctcct     2100

gtgttttagt atttggccca gaggtttcct aaatggttgc cttgaaatca ctgtggtcca     2160

aatgtaattc ttacacactc aaattatcac tgtctgtagc acacttgtgc acctgtctta     2220

cattctctgt tgctcccccc cacactcttg ctcagtctgt cacctgttca gtctgcttac     2280

tcactcaatt gttacccttt tgctgttgtc gtgtttacag tttgcatttt gaatgattag     2340

ttgggattac caaacatttt ttaaaaagat attatcaata aatatttttt taattctaaa     2400

ttttaaaaaa aaaaaaaaaa aaa                                             2423


<210>  749
<211>  436
<212>  PRT
<213>  Homo sapiens

<400>  749

Met Arg Arg Asp Val Asn Gly Val Thr Lys Ser Arg Phe Glu Met Phe 
1               5                   10                  15      


Ser Asn Ser Asp Glu Ala Val Ile Asn Lys Lys Leu Pro Lys Glu Leu 
            20                  25                  30          


Leu Leu Arg Ile Phe Ser Phe Leu Asp Val Val Thr Leu Cys Arg Cys 
        35                  40                  45              


Ala Gln Val Ser Arg Ala Trp Asn Val Leu Ala Leu Asp Gly Ser Asn 
    50                  55                  60                  


Trp Gln Arg Ile Asp Leu Phe Asp Phe Gln Arg Asp Ile Glu Gly Arg 
65                  70                  75                  80  


Val Val Glu Asn Ile Ser Lys Arg Cys Gly Gly Phe Leu Arg Lys Leu 
                85                  90                  95      


Ser Leu Arg Gly Cys Leu Gly Val Gly Asp Asn Ala Leu Arg Thr Phe 
            100                 105                 110         


Ala Gln Asn Cys Arg Asn Ile Glu Val Leu Asn Leu Asn Gly Cys Thr 
        115                 120                 125             


Lys Thr Thr Asp Ala Thr Cys Thr Ser Leu Ser Lys Phe Cys Ser Lys 
    130                 135                 140                 


Leu Arg His Leu Asp Leu Ala Ser Cys Thr Ser Ile Thr Asn Met Ser 
145                 150                 155                 160 


Leu Lys Ala Leu Ser Glu Gly Cys Pro Leu Leu Glu Gln Leu Asn Ile 
                165                 170                 175     


Ser Trp Cys Asp Gln Val Thr Lys Asp Gly Ile Gln Ala Leu Val Arg 
            180                 185                 190         


Gly Cys Gly Gly Leu Lys Ala Leu Phe Leu Lys Gly Cys Thr Gln Leu 
        195                 200                 205             


Glu Asp Glu Ala Leu Lys Tyr Ile Gly Ala His Cys Pro Glu Leu Val 
    210                 215                 220                 


Thr Leu Asn Leu Gln Thr Cys Leu Gln Ile Thr Asp Glu Gly Leu Ile 
225                 230                 235                 240 


Thr Ile Cys Arg Gly Cys His Lys Leu Gln Ser Leu Cys Ala Ser Gly 
                245                 250                 255     


Cys Ser Asn Ile Thr Asp Ala Ile Leu Asn Ala Leu Gly Gln Asn Cys 
            260                 265                 270         


Pro Arg Leu Arg Ile Leu Glu Val Ala Arg Cys Ser Gln Leu Thr Asp 
        275                 280                 285             


Val Gly Phe Thr Thr Leu Ala Arg Asn Cys His Glu Leu Glu Lys Met 
    290                 295                 300                 


Asp Leu Glu Glu Cys Val Gln Ile Thr Asp Ser Thr Leu Ile Gln Leu 
305                 310                 315                 320 


Ser Ile His Cys Pro Arg Leu Gln Val Leu Ser Leu Ser His Cys Glu 
                325                 330                 335     


Leu Ile Thr Asp Asp Gly Ile Arg His Leu Gly Asn Gly Ala Cys Ala 
            340                 345                 350         


His Asp Gln Leu Glu Val Ile Glu Leu Asp Asn Cys Pro Leu Ile Thr 
        355                 360                 365             


Asp Ala Ser Leu Glu His Leu Lys Ser Cys His Ser Leu Glu Arg Ile 
    370                 375                 380                 


Glu Leu Tyr Asp Cys Gln Gln Ile Thr Arg Ala Gly Ile Lys Arg Leu 
385                 390                 395                 400 


Arg Thr His Leu Pro Asn Ile Lys Val His Ala Tyr Phe Ala Pro Val 
                405                 410                 415     


Thr Pro Pro Pro Ser Val Gly Gly Ser Arg Gln Arg Phe Cys Arg Cys 
            420                 425                 430         


Cys Ile Ile Leu 
        435     


<210>  750
<211>  436
<212>  PRT
<213>  Homo sapiens

<400>  750

Met Arg Arg Asp Val Asn Gly Val Thr Lys Ser Arg Phe Glu Met Phe 
1               5                   10                  15      


Ser Asn Ser Asp Glu Ala Val Ile Asn Lys Lys Leu Pro Lys Glu Leu 
            20                  25                  30          


Leu Leu Arg Ile Phe Ser Phe Leu Asp Val Val Thr Leu Cys Arg Cys 
        35                  40                  45              


Ala Gln Val Ser Arg Ala Trp Asn Val Leu Ala Leu Asp Gly Ser Asn 
    50                  55                  60                  


Trp Gln Arg Ile Asp Leu Phe Asp Phe Gln Arg Asp Ile Glu Gly Arg 
65                  70                  75                  80  


Val Val Glu Asn Ile Ser Lys Arg Cys Gly Gly Phe Leu Arg Lys Leu 
                85                  90                  95      


Ser Leu Arg Gly Cys Leu Gly Val Gly Asp Asn Ala Leu Arg Thr Phe 
            100                 105                 110         


Ala Gln Asn Cys Arg Asn Ile Glu Val Leu Asn Leu Asn Gly Cys Thr 
        115                 120                 125             


Lys Thr Thr Asp Ala Thr Cys Thr Ser Leu Ser Lys Phe Cys Ser Lys 
    130                 135                 140                 


Leu Arg His Leu Asp Leu Ala Ser Cys Thr Ser Ile Thr Asn Met Ser 
145                 150                 155                 160 


Leu Lys Ala Leu Ser Glu Gly Cys Pro Leu Leu Glu Gln Leu Asn Ile 
                165                 170                 175     


Ser Trp Cys Asp Gln Val Thr Lys Asp Gly Ile Gln Ala Leu Val Arg 
            180                 185                 190         


Gly Cys Gly Gly Leu Lys Ala Leu Phe Leu Lys Gly Cys Thr Gln Leu 
        195                 200                 205             


Glu Asp Glu Ala Leu Lys Tyr Ile Gly Ala His Cys Pro Glu Leu Val 
    210                 215                 220                 


Thr Leu Asn Leu Gln Thr Cys Leu Gln Ile Thr Asp Glu Gly Leu Ile 
225                 230                 235                 240 


Thr Ile Cys Arg Gly Cys His Lys Leu Gln Ser Leu Cys Ala Ser Gly 
                245                 250                 255     


Cys Ser Asn Ile Thr Asp Ala Ile Leu Asn Ala Leu Gly Gln Asn Cys 
            260                 265                 270         


Pro Arg Leu Arg Ile Leu Glu Val Ala Arg Cys Ser Gln Leu Thr Asp 
        275                 280                 285             


Val Gly Phe Thr Thr Leu Ala Arg Asn Cys His Glu Leu Glu Lys Met 
    290                 295                 300                 


Asp Leu Glu Glu Cys Val Gln Ile Thr Asp Ser Thr Leu Ile Gln Leu 
305                 310                 315                 320 


Ser Ile His Cys Pro Arg Leu Gln Val Leu Ser Leu Ser His Cys Glu 
                325                 330                 335     


Leu Ile Thr Asp Asp Gly Ile Arg His Leu Gly Asn Gly Ala Cys Ala 
            340                 345                 350         


His Asp Gln Leu Glu Val Ile Glu Leu Asp Asn Cys Pro Leu Ile Thr 
        355                 360                 365             


Asp Ala Ser Leu Glu His Leu Lys Ser Cys His Ser Leu Glu Arg Ile 
    370                 375                 380                 


Glu Leu Tyr Asp Cys Gln Gln Ile Thr Arg Ala Gly Ile Lys Arg Leu 
385                 390                 395                 400 


Arg Thr His Leu Pro Asn Ile Lys Val His Ala Tyr Phe Ala Pro Val 
                405                 410                 415     


Thr Pro Pro Pro Ser Val Gly Gly Ser Arg Gln Arg Phe Cys Arg Cys 
            420                 425                 430         


Cys Ile Ile Leu 
        435     


<210>  751
<211>  3700
<212>  DNA
<213>  Homo sapiens

<400>  751
agagtaaagt gcagcctctc cagacactgg ggccccagtg ggcgtgggcg aagttgctgg       60

taggaggagt tggcggaagc acttggaact cctttataag tgtcagctgt gagattttaa      120

tttgatttga aaatgagtaa gtgcagaaag acaccagttc agcagctagc aagtcccgcg      180

tcattcagcc cagatattct tgctgacatt tttgaactct ttgccaagaa cttttcttat      240

ggcaagccac ttaataatga gtggcagtta ccagatccca gtgagatttt cacctgtgac      300

cacactgaac ttaatgcatt tcttgatttg aagaactccc taaatgaagt aaaaaaccta      360

ctgagtgata agaaactgga tgagtggcat gagcacactg ctttcactaa taaagcgggg      420

aaaatcattt ctcatgttag aaaatctgtg aatgctgaac tttgtactca agcatggtgt      480

aagttccatg agattttgtg cagctttcca cttattccac aggaagcttt tcagaatgga      540

aaactgaatt ctctacacct ttgtgaagct ccaggagctt ttatagctag tctcaaccac      600

tacttaaaat cccatcggtt tccttgtcat tggagttggg tagcgaatac tctgaatcca      660

taccatgaag caaatgacga cctcatgatg attatggatg accggcttat tgcaaatacc      720

ttgcactggt ggtactttgg tccagataac actggtgata tcatgaccct gaaattcttg      780

actggacttc agaatttcat aagcagcatg gctactgttc acttggtcac tgcagatggg      840

agttttgatt gccaaggaaa cccaggtgaa caagaagctt tagtttcttc tttgcattac      900

tgtgaagttg tcactgctct gaccactctt ggaaacggtg gctcttttgt tctaaagatg      960

tttactatgt ttgaacattg ttccataaac ttgatgtacc tgctaaactg ttgttttgac     1020

caagtccatg ttttcaaacc tgctactagc aaggcaggaa actccgaagt ctatgtggtt     1080

tgcctccact ataaggggag agaggccatc catcctctgt tatctaagat gaccttgaat     1140

tttgggactg aaatgaaaag gaaagccctt tttccccatc atgtgattcc tgattctttt     1200

cttaagagac atgaagaatg ttgtgtgttc tttcataaat atcagctaga gactatttct     1260

gaaaacattc gtctatttga gtgcatggga aaggcggaac aagaaaagct gaataattta     1320

agggattgtg ctatacaata ttttatgcaa aaatttcaac tgaaacatct ttccagaaat     1380

aattggctag taaaaaaatc tagtattggt tgtagtacaa atacaaaatg gtttgggcag     1440

aggaacaaat attttaaaac ttataatgaa aggaagatgc tagaagccct ttcatggaaa     1500

gataaagtag ccaaaggata ctttaatagt tgggctgaag aacatggtgt atatcatcct     1560

gggcagagtt ctattttaga aggaacagct tccaatcttg agtgtcactt atggcatatt     1620

ttggagggaa agaaactgcc aaaggtaaaa tgttctcctt tttgcaatgg tgaaatttta     1680

aaaactctta atgaagcaat tgaaaagtca ttaggaggag cttttaattt ggattccaag     1740

tttaggccaa aacagcagta ttcttgttct tgtcatgttt tttctgaaga actgatattt     1800

tccgagttgt gtagccttac tgagtgcctt caggatgagc aggttgtagt acccagcaat     1860

caaataaagt gcctgctggt gggcttttcg actctccgta atatcaaaat gcatataccg     1920

ttggaagttc gactcctaga atcagctgaa ctcacaactt ttagctgttc attgcttcat     1980

gatggagatc caacttacca gcgtttattt ttggactgcc ttctacattc attgcgggag     2040

cttcatacag gagatgttat gattttgcct gtactttctt gcttcacaag atttatggct     2100

ggtttgatct ttgtactcca cagttgtttt agattcatca cttttgtttg tcccacatcc     2160

tctgatcccc tgaggacctg cgcagtcctg ctatgtgttg gttatcagga ccttccaaat     2220

ccagttttcc gatatttgca gagtgtgaat gaattgttga gcactttgct caactctgac     2280

tcaccccagc aggttttaca gtttgtgcca atggaggtac tccttaaggg ggccctgctt     2340

gattttttgt gggatttgaa tgctgccatt gctaaaaggc atttgcattt cattattcaa     2400

agagagagag aagaaattat caacagcctt cagttacaaa actgaacata tgctttctga     2460

gattcaactt tatgatttct tataatttgc ccagtatttg catcctgttg ctctattaat     2520

ttaaaaacct tttattttgg ggaaaggcca acatttgcat cattcaaagt ctcattaatt     2580

ctggaaaacc atccattctg atctctaggg tatatacacc cacaggcata gagctcttcc     2640

acgtggtgga atctatgcaa tgatagatat tcacactcta aatatgaggt gtgtgtatgt     2700

gtatgggtgg ccacagccat gcttacctat gccatttagt tggtcttact taatctgctt     2760

aagatttgca tctgtgtacc tttgttcaga ttagtttttt ttttccagcc gatttcctct     2820

tagtggctaa tgctgttagt gaattttcca actaatttcc tctcattggt taatgttgtt     2880

aatgaattga gagaggtaat tgaggaaagg aaatgagtaa atcactgttc agcaacactg     2940

atttccgtta acacatcagt tatgaatttc agggaattca tctcgccaga ttcttgataa     3000

catgccattc attgccctta ggtgattgac cctattttct tacatggctc aaataaaact     3060

agtatgctgt tgtatgaatc ttttactgac cacaccatcc aactataaaa atataacggg     3120

acagctttaa accaaagatc atgtttagaa caatgaaaaa ttatttgttg tatctaatac     3180

acgcctgtat tgtgaaaagc ttcatttagc aatgatgtaa taatttttaa cttccaggaa     3240

ataatctgtg aatggaaaga ttttttaaga ttttgagata gtgtttagtc tcatgttggg     3300

aacacatgaa tgtgatgaac atagtgaata ctaaagaaaa cgcttcagac tttcagaatg     3360

atggttcaga atttaaaatt tttaatcttt tctaatttct ttttttcagt gtgaaaatag     3420

cactttacca aaagattagc catgaaatgg ttattttgcc agttacattt gatttctttt     3480

gtatctgcaa tgtaatgagt tattttattt cttctgtatt tgcagtgtaa tgagtttttg     3540

tggcaaagtg tattaagcaa tttttcatta tcttgaagtt ccacaaagtg gagaatattt     3600

atattctcac atgcatttta ggcacttttg atatgtgaaa atagatgtat tttctgatgc     3660

atttggttaa taaatattaa tcagaaaaaa aaaaaaaaaa                           3700


<210>  752
<211>  770
<212>  PRT
<213>  Homo sapiens

<400>  752

Met Ser Lys Cys Arg Lys Thr Pro Val Gln Gln Leu Ala Ser Pro Ala 
1               5                   10                  15      


Ser Phe Ser Pro Asp Ile Leu Ala Asp Ile Phe Glu Leu Phe Ala Lys 
            20                  25                  30          


Asn Phe Ser Tyr Gly Lys Pro Leu Asn Asn Glu Trp Gln Leu Pro Asp 
        35                  40                  45              


Pro Ser Glu Ile Phe Thr Cys Asp His Thr Glu Leu Asn Ala Phe Leu 
    50                  55                  60                  


Asp Leu Lys Asn Ser Leu Asn Glu Val Lys Asn Leu Leu Ser Asp Lys 
65                  70                  75                  80  


Lys Leu Asp Glu Trp His Glu His Thr Ala Phe Thr Asn Lys Ala Gly 
                85                  90                  95      


Lys Ile Ile Ser His Val Arg Lys Ser Val Asn Ala Glu Leu Cys Thr 
            100                 105                 110         


Gln Ala Trp Cys Lys Phe His Glu Ile Leu Cys Ser Phe Pro Leu Ile 
        115                 120                 125             


Pro Gln Glu Ala Phe Gln Asn Gly Lys Leu Asn Ser Leu His Leu Cys 
    130                 135                 140                 


Glu Ala Pro Gly Ala Phe Ile Ala Ser Leu Asn His Tyr Leu Lys Ser 
145                 150                 155                 160 


His Arg Phe Pro Cys His Trp Ser Trp Val Ala Asn Thr Leu Asn Pro 
                165                 170                 175     


Tyr His Glu Ala Asn Asp Asp Leu Met Met Ile Met Asp Asp Arg Leu 
            180                 185                 190         


Ile Ala Asn Thr Leu His Trp Trp Tyr Phe Gly Pro Asp Asn Thr Gly 
        195                 200                 205             


Asp Ile Met Thr Leu Lys Phe Leu Thr Gly Leu Gln Asn Phe Ile Ser 
    210                 215                 220                 


Ser Met Ala Thr Val His Leu Val Thr Ala Asp Gly Ser Phe Asp Cys 
225                 230                 235                 240 


Gln Gly Asn Pro Gly Glu Gln Glu Ala Leu Val Ser Ser Leu His Tyr 
                245                 250                 255     


Cys Glu Val Val Thr Ala Leu Thr Thr Leu Gly Asn Gly Gly Ser Phe 
            260                 265                 270         


Val Leu Lys Met Phe Thr Met Phe Glu His Cys Ser Ile Asn Leu Met 
        275                 280                 285             


Tyr Leu Leu Asn Cys Cys Phe Asp Gln Val His Val Phe Lys Pro Ala 
    290                 295                 300                 


Thr Ser Lys Ala Gly Asn Ser Glu Val Tyr Val Val Cys Leu His Tyr 
305                 310                 315                 320 


Lys Gly Arg Glu Ala Ile His Pro Leu Leu Ser Lys Met Thr Leu Asn 
                325                 330                 335     


Phe Gly Thr Glu Met Lys Arg Lys Ala Leu Phe Pro His His Val Ile 
            340                 345                 350         


Pro Asp Ser Phe Leu Lys Arg His Glu Glu Cys Cys Val Phe Phe His 
        355                 360                 365             


Lys Tyr Gln Leu Glu Thr Ile Ser Glu Asn Ile Arg Leu Phe Glu Cys 
    370                 375                 380                 


Met Gly Lys Ala Glu Gln Glu Lys Leu Asn Asn Leu Arg Asp Cys Ala 
385                 390                 395                 400 


Ile Gln Tyr Phe Met Gln Lys Phe Gln Leu Lys His Leu Ser Arg Asn 
                405                 410                 415     


Asn Trp Leu Val Lys Lys Ser Ser Ile Gly Cys Ser Thr Asn Thr Lys 
            420                 425                 430         


Trp Phe Gly Gln Arg Asn Lys Tyr Phe Lys Thr Tyr Asn Glu Arg Lys 
        435                 440                 445             


Met Leu Glu Ala Leu Ser Trp Lys Asp Lys Val Ala Lys Gly Tyr Phe 
    450                 455                 460                 


Asn Ser Trp Ala Glu Glu His Gly Val Tyr His Pro Gly Gln Ser Ser 
465                 470                 475                 480 


Ile Leu Glu Gly Thr Ala Ser Asn Leu Glu Cys His Leu Trp His Ile 
                485                 490                 495     


Leu Glu Gly Lys Lys Leu Pro Lys Val Lys Cys Ser Pro Phe Cys Asn 
            500                 505                 510         


Gly Glu Ile Leu Lys Thr Leu Asn Glu Ala Ile Glu Lys Ser Leu Gly 
        515                 520                 525             


Gly Ala Phe Asn Leu Asp Ser Lys Phe Arg Pro Lys Gln Gln Tyr Ser 
    530                 535                 540                 


Cys Ser Cys His Val Phe Ser Glu Glu Leu Ile Phe Ser Glu Leu Cys 
545                 550                 555                 560 


Ser Leu Thr Glu Cys Leu Gln Asp Glu Gln Val Val Val Pro Ser Asn 
                565                 570                 575     


Gln Ile Lys Cys Leu Leu Val Gly Phe Ser Thr Leu Arg Asn Ile Lys 
            580                 585                 590         


Met His Ile Pro Leu Glu Val Arg Leu Leu Glu Ser Ala Glu Leu Thr 
        595                 600                 605             


Thr Phe Ser Cys Ser Leu Leu His Asp Gly Asp Pro Thr Tyr Gln Arg 
    610                 615                 620                 


Leu Phe Leu Asp Cys Leu Leu His Ser Leu Arg Glu Leu His Thr Gly 
625                 630                 635                 640 


Asp Val Met Ile Leu Pro Val Leu Ser Cys Phe Thr Arg Phe Met Ala 
                645                 650                 655     


Gly Leu Ile Phe Val Leu His Ser Cys Phe Arg Phe Ile Thr Phe Val 
            660                 665                 670         


Cys Pro Thr Ser Ser Asp Pro Leu Arg Thr Cys Ala Val Leu Leu Cys 
        675                 680                 685             


Val Gly Tyr Gln Asp Leu Pro Asn Pro Val Phe Arg Tyr Leu Gln Ser 
    690                 695                 700                 


Val Asn Glu Leu Leu Ser Thr Leu Leu Asn Ser Asp Ser Pro Gln Gln 
705                 710                 715                 720 


Val Leu Gln Phe Val Pro Met Glu Val Leu Leu Lys Gly Ala Leu Leu 
                725                 730                 735     


Asp Phe Leu Trp Asp Leu Asn Ala Ala Ile Ala Lys Arg His Leu His 
            740                 745                 750         


Phe Ile Ile Gln Arg Glu Arg Glu Glu Ile Ile Asn Ser Leu Gln Leu 
        755                 760                 765             


Gln Asn 
    770 


<210>  753
<211>  770
<212>  PRT
<213>  Homo sapiens

<400>  753

Met Ser Lys Cys Arg Lys Thr Pro Val Gln Gln Leu Ala Ser Pro Ala 
1               5                   10                  15      


Ser Phe Ser Pro Asp Ile Leu Ala Asp Ile Phe Glu Leu Phe Ala Lys 
            20                  25                  30          


Asn Phe Ser Tyr Gly Lys Pro Leu Asn Asn Glu Trp Gln Leu Pro Asp 
        35                  40                  45              


Pro Ser Glu Ile Phe Thr Cys Asp His Thr Glu Leu Asn Ala Phe Leu 
    50                  55                  60                  


Asp Leu Lys Asn Ser Leu Asn Glu Val Lys Asn Leu Leu Ser Asp Lys 
65                  70                  75                  80  


Lys Leu Asp Glu Trp His Glu His Thr Ala Phe Thr Asn Lys Ala Gly 
                85                  90                  95      


Lys Ile Ile Ser His Val Arg Lys Ser Val Asn Ala Glu Leu Cys Thr 
            100                 105                 110         


Gln Ala Trp Cys Lys Phe His Glu Ile Leu Cys Ser Phe Pro Leu Ile 
        115                 120                 125             


Pro Gln Glu Ala Phe Gln Asn Gly Lys Leu Asn Ser Leu His Leu Cys 
    130                 135                 140                 


Glu Ala Pro Gly Ala Phe Ile Ala Ser Leu Asn His Tyr Leu Lys Ser 
145                 150                 155                 160 


His Arg Phe Pro Cys His Trp Ser Trp Val Ala Asn Thr Leu Asn Pro 
                165                 170                 175     


Tyr His Glu Ala Asn Asp Asp Leu Met Met Ile Met Asp Asp Arg Leu 
            180                 185                 190         


Ile Ala Asn Thr Leu His Trp Trp Tyr Phe Gly Pro Asp Asn Thr Gly 
        195                 200                 205             


Asp Ile Met Thr Leu Lys Phe Leu Thr Gly Leu Gln Asn Phe Ile Ser 
    210                 215                 220                 


Ser Met Ala Thr Val His Leu Val Thr Ala Asp Gly Ser Phe Asp Cys 
225                 230                 235                 240 


Gln Gly Asn Pro Gly Glu Gln Glu Ala Leu Val Ser Ser Leu His Tyr 
                245                 250                 255     


Cys Glu Val Val Thr Ala Leu Thr Thr Leu Gly Asn Gly Gly Ser Phe 
            260                 265                 270         


Val Leu Lys Met Phe Thr Met Phe Glu His Cys Ser Ile Asn Leu Met 
        275                 280                 285             


Tyr Leu Leu Asn Cys Cys Phe Asp Gln Val His Val Phe Lys Pro Ala 
    290                 295                 300                 


Thr Ser Lys Ala Gly Asn Ser Glu Val Tyr Val Val Cys Leu His Tyr 
305                 310                 315                 320 


Lys Gly Arg Glu Ala Ile His Pro Leu Leu Ser Lys Met Thr Leu Asn 
                325                 330                 335     


Phe Gly Thr Glu Met Lys Arg Lys Ala Leu Phe Pro His His Val Ile 
            340                 345                 350         


Pro Asp Ser Phe Leu Lys Arg His Glu Glu Cys Cys Val Phe Phe His 
        355                 360                 365             


Lys Tyr Gln Leu Glu Thr Ile Ser Glu Asn Ile Arg Leu Phe Glu Cys 
    370                 375                 380                 


Met Gly Lys Ala Glu Gln Glu Lys Leu Asn Asn Leu Arg Asp Cys Ala 
385                 390                 395                 400 


Ile Gln Tyr Phe Met Gln Lys Phe Gln Leu Lys His Leu Ser Arg Asn 
                405                 410                 415     


Asn Trp Leu Val Lys Lys Ser Ser Ile Gly Cys Ser Thr Asn Thr Lys 
            420                 425                 430         


Trp Phe Gly Gln Arg Asn Lys Tyr Phe Lys Thr Tyr Asn Glu Arg Lys 
        435                 440                 445             


Met Leu Glu Ala Leu Ser Trp Lys Asp Lys Val Ala Lys Gly Tyr Phe 
    450                 455                 460                 


Asn Ser Trp Ala Glu Glu His Gly Val Tyr His Pro Gly Gln Ser Ser 
465                 470                 475                 480 


Ile Leu Glu Gly Thr Ala Ser Asn Leu Glu Cys His Leu Trp His Ile 
                485                 490                 495     


Leu Glu Gly Lys Lys Leu Pro Lys Val Lys Cys Ser Pro Phe Cys Asn 
            500                 505                 510         


Gly Glu Ile Leu Lys Thr Leu Asn Glu Ala Ile Glu Lys Ser Leu Gly 
        515                 520                 525             


Gly Ala Phe Asn Leu Asp Ser Lys Phe Arg Pro Lys Gln Gln Tyr Ser 
    530                 535                 540                 


Cys Ser Cys His Val Phe Ser Glu Glu Leu Ile Phe Ser Glu Leu Cys 
545                 550                 555                 560 


Ser Leu Thr Glu Cys Leu Gln Asp Glu Gln Val Val Val Pro Ser Asn 
                565                 570                 575     


Gln Ile Lys Cys Leu Leu Val Gly Phe Ser Thr Leu Arg Asn Ile Lys 
            580                 585                 590         


Met His Ile Pro Leu Glu Val Arg Leu Leu Glu Ser Ala Glu Leu Thr 
        595                 600                 605             


Thr Phe Ser Cys Ser Leu Leu His Asp Gly Asp Pro Thr Tyr Gln Arg 
    610                 615                 620                 


Leu Phe Leu Asp Cys Leu Leu His Ser Leu Arg Glu Leu His Thr Gly 
625                 630                 635                 640 


Asp Val Met Ile Leu Pro Val Leu Ser Cys Phe Thr Arg Phe Met Ala 
                645                 650                 655     


Gly Leu Ile Phe Val Leu His Ser Cys Phe Arg Phe Ile Thr Phe Val 
            660                 665                 670         


Cys Pro Thr Ser Ser Asp Pro Leu Arg Thr Cys Ala Val Leu Leu Cys 
        675                 680                 685             


Val Gly Tyr Gln Asp Leu Pro Asn Pro Val Phe Arg Tyr Leu Gln Ser 
    690                 695                 700                 


Val Asn Glu Leu Leu Ser Thr Leu Leu Asn Ser Asp Ser Pro Gln Gln 
705                 710                 715                 720 


Val Leu Gln Phe Val Pro Met Glu Val Leu Leu Lys Gly Ala Leu Leu 
                725                 730                 735     


Asp Phe Leu Trp Asp Leu Asn Ala Ala Ile Ala Lys Arg His Leu His 
            740                 745                 750         


Phe Ile Ile Gln Arg Glu Arg Glu Glu Ile Ile Asn Ser Leu Gln Leu 
        755                 760                 765             


Gln Asn 
    770 


<210>  754
<211>  1997
<212>  DNA
<213>  Homo sapiens

<400>  754
cagagaccca ggctcctgca ggagatgacc agggacagtt aagagttgaa attgatgaag       60

agatccaggt acaagggcaa ggaaataaga atgacggtgg agttgaggat gttgcagaac      120

tccaggatat aggaagccag agaaagtgca cagatgagga tgttggagag cctcgagcac      180

caaggggagg aaacaaggat ctggtcagag gagaggatgc tgtgagggac agtctccaag      240

tcgactgttc tgggagtgag aggcccacag gcaggaagca cagcctacca tggcctccag      300

ccttcactgg ctatggatgt gggacccggg aacaggaaca ggcagtggct gtgaatggtt      360

tcatctctgc cccctgtcct gagatgaatc ctgtccccca ctggggtgaa gtcttcctgc      420

tggtgggtgg ggagggagag catctggcca gccagggcac aacccctgcc agggatcata      480

gagtggggat cagtccagcc tcccagcagg cccaacctga atcctggaga agacgacaaa      540

gggacaaagg ggtggatcca gagaaggccc ccagcctgac tcggcagtcc caaaaccctc      600

cgtctctgac agctcccttg ggcatgccct ctgcctgctc ctgtctcccg tgtggcccag      660

ccccggaagc tgccatcatt ctagcgggtc ctcccaccgc cctcactgtc ctgcccaagg      720

ggacaggcct caagaagagc aaacgactgc tcctggagtc cctcatgcgg aggaggattg      780

cacacctgaa gtggggtctt ccccggcgga tcctggagtc ctatttcctg tttaacttct      840

taggatcttg ctcattgacc cttgctgggg cgaggctctc tggactgaac acaggccagg      900

agctccaagc ccagcaggaa aggtattgtg aggcccaagg ctccccacca ggccttaagt      960

ccccagagag gttccagagg gttcagcgcc cagacagaaa aagctcgaaa cttcctatac     1020

aagccagagc tctggagagg aacagaccgc acatgtcaga gcccattaag catttccatc     1080

cagcctgaaa aggccaggag agtcaggcca ccagggggcg ccagagaacc acaggagatc     1140

caggaagcgc ttgctaggac caagctccca gctcccagga cccccaggcc ggcagcggag     1200

tccaggagct ggtgtggccc acaaagggtc ggagagcctc ccagtgagaa cagtaggggc     1260

aggaaaatga tcaggtcaag ggtctcccag ctggcagaga gggctcccag cagagtgagg     1320

acttcattct ctagggcaga ccacgcccac tggaggaagg aatgtacatc ctgggaggcc     1380

tctaagctcc ccagactcaa atgccagcag ctcacatact ggagaagagg aagcctggaa     1440

tctacagggt gcagaggggc tgggcagcag ccttcctgcc attctgcaga acctgtcagc     1500

ttcaaaggga ggctccactc tgcggtggca aagctgggcc tgacccttct ggccaagatg     1560

tcctggtccc cacagctcgc caagcgcaag cacttggccc ctaacctgag cctgagggaa     1620

cctgattcta ctctgcctcc caaagtgggt gatcctcgtg caggggagga cagcatcgga     1680

gatcacactg cttcacagag ggatcttcag ctgcaaggtc actgctgtac tggggccacc     1740

cttcctaaga cagagagtcc ccagggccag gaggcacctg ggaacccaaa tggggctcca     1800

cagaatacac gagcctccaa aaagtttagt attatgaagc atctgaattt ttttctcttc     1860

cagaatggct ttaaaaagta gactcaggcc cagagtcctc aggacatatc agaaaagctt     1920

tgagagtgtc ctgatccctg caaagcctct aataaattgg tcatttggga aaaaaaaaaa     1980

aaaaaaaaaa aaaaaaa                                                    1997


<210>  755
<211>  234
<212>  PRT
<213>  Homo sapiens

<400>  755

Met Asn Pro Val Pro His Trp Gly Glu Val Phe Leu Leu Val Gly Gly 
1               5                   10                  15      


Glu Gly Glu His Leu Ala Ser Gln Gly Thr Thr Pro Ala Arg Asp His 
            20                  25                  30          


Arg Val Gly Ile Ser Pro Ala Ser Gln Gln Ala Gln Pro Glu Ser Trp 
        35                  40                  45              


Arg Arg Arg Gln Arg Asp Lys Gly Val Asp Pro Glu Lys Ala Pro Ser 
    50                  55                  60                  


Leu Thr Arg Gln Ser Gln Asn Pro Pro Ser Leu Thr Ala Pro Leu Gly 
65                  70                  75                  80  


Met Pro Ser Ala Cys Ser Cys Leu Pro Cys Gly Pro Ala Pro Glu Ala 
                85                  90                  95      


Ala Ile Ile Leu Ala Gly Pro Pro Thr Ala Leu Thr Val Leu Pro Lys 
            100                 105                 110         


Gly Thr Gly Leu Lys Lys Ser Lys Arg Leu Leu Leu Glu Ser Leu Met 
        115                 120                 125             


Arg Arg Arg Ile Ala His Leu Lys Trp Gly Leu Pro Arg Arg Ile Leu 
    130                 135                 140                 


Glu Ser Tyr Phe Leu Phe Asn Phe Leu Gly Ser Cys Ser Leu Thr Leu 
145                 150                 155                 160 


Ala Gly Ala Arg Leu Ser Gly Leu Asn Thr Gly Gln Glu Leu Gln Ala 
                165                 170                 175     


Gln Gln Glu Arg Tyr Cys Glu Ala Gln Gly Ser Pro Pro Gly Leu Lys 
            180                 185                 190         


Ser Pro Glu Arg Phe Gln Arg Val Gln Arg Pro Asp Arg Lys Ser Ser 
        195                 200                 205             


Lys Leu Pro Ile Gln Ala Arg Ala Leu Glu Arg Asn Arg Pro His Met 
    210                 215                 220                 


Ser Glu Pro Ile Lys His Phe His Pro Ala 
225                 230                 


<210>  756
<211>  234
<212>  PRT
<213>  Homo sapiens

<400>  756

Met Asn Pro Val Pro His Trp Gly Glu Val Phe Leu Leu Val Gly Gly 
1               5                   10                  15      


Glu Gly Glu His Leu Ala Ser Gln Gly Thr Thr Pro Ala Arg Asp His 
            20                  25                  30          


Arg Val Gly Ile Ser Pro Ala Ser Gln Gln Ala Gln Pro Glu Ser Trp 
        35                  40                  45              


Arg Arg Arg Gln Arg Asp Lys Gly Val Asp Pro Glu Lys Ala Pro Ser 
    50                  55                  60                  


Leu Thr Arg Gln Ser Gln Asn Pro Pro Ser Leu Thr Ala Pro Leu Gly 
65                  70                  75                  80  


Met Pro Ser Ala Cys Ser Cys Leu Pro Cys Gly Pro Ala Pro Glu Ala 
                85                  90                  95      


Ala Ile Ile Leu Ala Gly Pro Pro Thr Ala Leu Thr Val Leu Pro Lys 
            100                 105                 110         


Gly Thr Gly Leu Lys Lys Ser Lys Arg Leu Leu Leu Glu Ser Leu Met 
        115                 120                 125             


Arg Arg Arg Ile Ala His Leu Lys Trp Gly Leu Pro Arg Arg Ile Leu 
    130                 135                 140                 


Glu Ser Tyr Phe Leu Phe Asn Phe Leu Gly Ser Cys Ser Leu Thr Leu 
145                 150                 155                 160 


Ala Gly Ala Arg Leu Ser Gly Leu Asn Thr Gly Gln Glu Leu Gln Ala 
                165                 170                 175     


Gln Gln Glu Arg Tyr Cys Glu Ala Gln Gly Ser Pro Pro Gly Leu Lys 
            180                 185                 190         


Ser Pro Glu Arg Phe Gln Arg Val Gln Arg Pro Asp Arg Lys Ser Ser 
        195                 200                 205             


Lys Leu Pro Ile Gln Ala Arg Ala Leu Glu Arg Asn Arg Pro His Met 
    210                 215                 220                 


Ser Glu Pro Ile Lys His Phe His Pro Ala 
225                 230                 


<210>  757
<211>  788
<212>  DNA
<213>  Homo sapiens

<400>  757
cttctacacc cgcctccaga caggagaggg gcacgtaccg gcgctacggc ttcctgcagg       60

ctgcctccgg atagtccccg agagcttgtt ccgaagcaag caccctgcag ccctagcgat      120

ccagccctcc cctggaccct aggtcacggc aatcaacccc ctgctgtggt tcccgaaccc      180

caaggcccga tgggtcccgc gggggtcgcg gcgaggccag ggcgcttttt cggcgtctac      240

ctgctctact gcctgaaccc ccggtaccgg ggccgcgtct acgtggggtt cactgtcaac      300

actgctcgtc gggtccagca gcacaatggg ggccgcaaaa aaggcggggc ctggcggacc      360

agcgggcgag ggccctggga gatggtgctc gtcgtgcacg gcttcccgtc ctccgtggcc      420

gcccttcggg atgaagaggg gcccttgtgt tgcccccacc ctggctgcct gctaagggcc      480

catgtgatct gcctggcaga ggagtttctt caggaagaac cagggcagct tctgccccta      540

gagggccaat gcccttgctg tgagaagtca ctgctttggg gagacctgat ctggctgtgc      600

cagatggaca ctgagaaaga agtagaagac tcagaattag aagaggcaca ctggacagac      660

ctgctggaga cctgatcctc agtgtcctta ccccctccta cctcttttct gtgccacctg      720

ctgtgggtcc agcaggtttt tacttgagta caataaaaag tctgagtcaa aaaaaaaaaa      780

aaaaaaaa                                                               788


<210>  758
<211>  275
<212>  PRT
<213>  Homo sapiens

<400>  758

Met Gly Pro Ala Gly Val Ala Ala Arg Pro Gly Arg Phe Phe Gly Val 
1               5                   10                  15      


Tyr Leu Leu Tyr Cys Leu Asn Pro Arg Tyr Arg Gly Arg Val Tyr Val 
            20                  25                  30          


Gly Phe Thr Val Asn Thr Ala Arg Arg Val Gln Gln His Asn Gly Gly 
        35                  40                  45              


Arg Lys Lys Gly Gly Ala Trp Arg Thr Ser Gly Arg Gly Pro Trp Glu 
    50                  55                  60                  


Met Val Leu Val Val His Gly Phe Pro Ser Ser Val Ala Ala Leu Arg 
65                  70                  75                  80  


Phe Glu Trp Ala Trp Gln His Pro His Ala Ser Arg Arg Leu Ala His 
                85                  90                  95      


Val Gly Pro Arg Leu Arg Gly Glu Thr Ala Phe Ala Phe His Leu Arg 
            100                 105                 110         


Val Leu Ala His Met Leu Arg Ala Pro Pro Trp Ala Arg Leu Pro Leu 
        115                 120                 125             


Thr Leu Arg Trp Val Arg Pro Asp Leu Arg Gln Asp Leu Cys Leu Pro 
    130                 135                 140                 


Pro Pro Pro His Val Pro Leu Ala Phe Gly Pro Pro Pro Pro Gln Ala 
145                 150                 155                 160 


Pro Ala Pro Arg Arg Arg Ala Gly Pro Phe Asp Asp Ala Glu Pro Glu 
                165                 170                 175     


Pro Asp Gln Gly Asp Pro Gly Ala Cys Cys Ser Leu Cys Ala Gln Thr 
            180                 185                 190         


Ile Gln Asp Glu Glu Gly Pro Leu Cys Cys Pro His Pro Gly Cys Leu 
        195                 200                 205             


Leu Arg Ala His Val Ile Cys Leu Ala Glu Glu Phe Leu Gln Glu Glu 
    210                 215                 220                 


Pro Gly Gln Leu Leu Pro Leu Glu Gly Gln Cys Pro Cys Cys Glu Lys 
225                 230                 235                 240 


Ser Leu Leu Trp Gly Asp Leu Ile Trp Leu Cys Gln Met Asp Thr Glu 
                245                 250                 255     


Lys Glu Val Glu Asp Ser Glu Leu Glu Glu Ala His Trp Thr Asp Leu 
            260                 265                 270         


Leu Glu Thr 
        275 


<210>  759
<211>  161
<212>  PRT
<213>  Homo sapiens

<400>  759

Met Gly Pro Ala Gly Val Ala Ala Arg Pro Gly Arg Phe Phe Gly Val 
1               5                   10                  15      


Tyr Leu Leu Tyr Cys Leu Asn Pro Arg Tyr Arg Gly Arg Val Tyr Val 
            20                  25                  30          


Gly Phe Thr Val Asn Thr Ala Arg Arg Val Gln Gln His Asn Gly Gly 
        35                  40                  45              


Arg Lys Lys Gly Gly Ala Trp Arg Thr Ser Gly Arg Gly Pro Trp Glu 
    50                  55                  60                  


Met Val Leu Val Val His Gly Phe Pro Ser Ser Val Ala Ala Leu Arg 
65                  70                  75                  80  


Asp Glu Glu Gly Pro Leu Cys Cys Pro His Pro Gly Cys Leu Leu Arg 
                85                  90                  95      


Ala His Val Ile Cys Leu Ala Glu Glu Phe Leu Gln Glu Glu Pro Gly 
            100                 105                 110         


Gln Leu Leu Pro Leu Glu Gly Gln Cys Pro Cys Cys Glu Lys Ser Leu 
        115                 120                 125             


Leu Trp Gly Asp Leu Ile Trp Leu Cys Gln Met Asp Thr Glu Lys Glu 
    130                 135                 140                 


Val Glu Asp Ser Glu Leu Glu Glu Ala His Trp Thr Asp Leu Leu Glu 
145                 150                 155                 160 


Thr 
    


<210>  760
<211>  2385
<212>  DNA
<213>  Homo sapiens

<400>  760
agcggtctaa gaggatggca tcagcgccgc caaagacgtg aaattactcc tgctcggggc       60

tggagaatca ggaaaaagca ccattgtgaa gcagatgaag atcatccatg aagatggctt      120

ctccggagaa gacgtgaaac agtacaagcc tgttgtctac agcaacacta tccagtccct      180

ggcagccatc gtccgggcca tggacacttt gggcatcgaa tatggtgata aggagagaaa      240

ggctgacgcc aagatggtgt gtgatgtggt gagtcggatg gaagacaccg agcccttctc      300

tgcagagctg ctttctgcca tgatgcggct ctggggcgac tcaggaatcc aagagtgctt      360

caaccggtcc cgggagtatc agctcaacga ctctgccaaa tactacctgg acagcctgga      420

tcggattggg gccgccgact accagcccac cgagcaggac atcctccgaa ccagggtcaa      480

aaccactggc atcgtagaaa cccacttcac attcaagaac ctccacttca ggctgtttga      540

cgtcggaggc cagcgatctg aacgcaagaa gtggatccat tgcttcgagg acgtcacggc      600

catcattttc tgtgtcgcgc tcagcggcta tgaccaggtg ctccacgaag acgaaaccac      660

gaaccgcatg cacgagtctc tcatgctctt cgactccatc tgtaacaaca agttcttcat      720

cgatacctcc atcattctct tcctcaacaa gaaagatctc tttggcgaga agatcaagaa      780

gtcacctttg accatctgct ttcctgaata cacaggcccc aatacctatg aagacgcagc      840

cgcctacatc caagcacaat ttgaaagcaa aaaccgctca cccaacaaag aaatatattg      900

tcacatgact tgtgccacag acacgaataa catccaggtg gtgttcgacg ccgtcaccga      960

catcatcatt gccaacaacc tccggggctg cggcttgtac tgacctcttg tcctgtatag     1020

caacctattt gactgcttca cggactcttt gctgttgacg ttgatctcct ggtagcatga     1080

ccttttggcc tttgtaagac acacagcctt tctgtatcaa gcccctgtct aacctacgac     1140

cccagagtga ctgacggctg tgtatttctg tagaatgctg tagaatccgg ttttagttga     1200

gtcttcacat ttagaatttg aaaggaaaaa cagaacattt ctcatgtgct ttgtagctta     1260

aaaaaaggaa aactcaccat ttcatccata tttctttttc ttgcaaaaca aacataccca     1320

tctgcaccga cgcctgcccc cgtcccacct cgcggcgcag cccctggagc tcctgctggg     1380

gggcagggcc catctgccgc ctggggctcc ggtgcggtgc actggtccga ggagtgtgct     1440

caggccgggc tttccagaag gccacaggcc actgcaaacc ctgctgcctg ccggccgccc     1500

agacaccaca gacgccacct ggcggcccta aggcactccc gccacacgct cactccaggt     1560

tcgtatagaa aaagcacagc tctcactggc cagtagctgc caaaaagaac acccatcgta     1620

taaggaaatc cagccccata gaaaacaatc tgcccaccga ccccctttct aaggatagcc     1680

tttgtagggg ttttttggtt cctttttttt ttttttcagt ttttgttttt acttttgtcc     1740

cgccgagtac tatgtattac cagcccccca ccccacagat cagttttcct agtctttggg     1800

aaacgggttg tgtttttttt cctttgcagt gttggatttc cggtcccggc tgacacctcc     1860

cttcgtgtgt gcgcccctcc ccacccctgc ctttgtttcg gtgccctgtg tccgctctct     1920

catgtgggga tgtttgtgct gcagacaaaa agaacaaaaa aaaattttta aataccacaa     1980

gatggaaaaa aaaacaaaaa aatttaaaaa gatggaatgt agtgtttaca ttaaagccgc     2040

cgttttcatg accaatccta tgtcatttct actttgacta atacccaaac cctaaacatc     2100

ttcacggttt cacttttaag acttaatctt tgctgaagaa gaccagtcac agccatttca     2160

aataaagagg aggcaaaaag acaaaacaca caaaaaatta aaaaaaaaaa cttaaaaaaa     2220

aaaggaaaaa agaaaaaaaa gcccacgggt ctttgtaagc ctttctattc ccaatcggtg     2280

aggtttctgt gatatcttac acactgccag tctacttctc tgactaatgg aaaattcctg     2340

tgtagctcaa taaaagagaa tgtttgtctg caaaaaaaaa aaaaa                     2385


<210>  761
<211>  354
<212>  PRT
<213>  Homo sapiens

<400>  761

Met Gly Cys Thr Leu Ser Ala Glu Glu Arg Ala Ala Leu Glu Arg Ser 
1               5                   10                  15      


Lys Ala Ile Glu Lys Asn Leu Lys Glu Asp Gly Ile Ser Ala Ala Lys 
            20                  25                  30          


Asp Val Lys Leu Leu Leu Leu Gly Ala Gly Glu Ser Gly Lys Ser Thr 
        35                  40                  45              


Ile Val Lys Gln Met Lys Ile Ile His Glu Asp Gly Phe Ser Gly Glu 
    50                  55                  60                  


Asp Val Lys Gln Tyr Lys Pro Val Val Tyr Ser Asn Thr Ile Gln Ser 
65                  70                  75                  80  


Leu Ala Ala Ile Val Arg Ala Met Asp Thr Leu Gly Ile Glu Tyr Gly 
                85                  90                  95      


Asp Lys Glu Arg Lys Ala Asp Ala Lys Met Val Cys Asp Val Val Ser 
            100                 105                 110         


Arg Met Glu Asp Thr Glu Pro Phe Ser Ala Glu Leu Leu Ser Ala Met 
        115                 120                 125             


Met Arg Leu Trp Gly Asp Ser Gly Ile Gln Glu Cys Phe Asn Arg Ser 
    130                 135                 140                 


Arg Glu Tyr Gln Leu Asn Asp Ser Ala Lys Tyr Tyr Leu Asp Ser Leu 
145                 150                 155                 160 


Asp Arg Ile Gly Ala Ala Asp Tyr Gln Pro Thr Glu Gln Asp Ile Leu 
                165                 170                 175     


Arg Thr Arg Val Lys Thr Thr Gly Ile Val Glu Thr His Phe Thr Phe 
            180                 185                 190         


Lys Asn Leu His Phe Arg Leu Phe Asp Val Gly Gly Gln Arg Ser Glu 
        195                 200                 205             


Arg Lys Lys Trp Ile His Cys Phe Glu Asp Val Thr Ala Ile Ile Phe 
    210                 215                 220                 


Cys Val Ala Leu Ser Gly Tyr Asp Gln Val Leu His Glu Asp Glu Thr 
225                 230                 235                 240 


Thr Asn Arg Met His Glu Ser Leu Met Leu Phe Asp Ser Ile Cys Asn 
                245                 250                 255     


Asn Lys Phe Phe Ile Asp Thr Ser Ile Ile Leu Phe Leu Asn Lys Lys 
            260                 265                 270         


Asp Leu Phe Gly Glu Lys Ile Lys Lys Ser Pro Leu Thr Ile Cys Phe 
        275                 280                 285             


Pro Glu Tyr Thr Gly Pro Asn Thr Tyr Glu Asp Ala Ala Ala Tyr Ile 
    290                 295                 300                 


Gln Ala Gln Phe Glu Ser Lys Asn Arg Ser Pro Asn Lys Glu Ile Tyr 
305                 310                 315                 320 


Cys His Met Thr Cys Ala Thr Asp Thr Asn Asn Ile Gln Val Val Phe 
                325                 330                 335     


Asp Ala Val Thr Asp Ile Ile Ile Ala Asn Asn Leu Arg Gly Cys Gly 
            340                 345                 350         


Leu Tyr 
        


<210>  762
<211>  249
<212>  PRT
<213>  Homo sapiens

<400>  762

Met Val Cys Asp Val Val Ser Arg Met Glu Asp Thr Glu Pro Phe Ser 
1               5                   10                  15      


Ala Glu Leu Leu Ser Ala Met Met Arg Leu Trp Gly Asp Ser Gly Ile 
            20                  25                  30          


Gln Glu Cys Phe Asn Arg Ser Arg Glu Tyr Gln Leu Asn Asp Ser Ala 
        35                  40                  45              


Lys Tyr Tyr Leu Asp Ser Leu Asp Arg Ile Gly Ala Ala Asp Tyr Gln 
    50                  55                  60                  


Pro Thr Glu Gln Asp Ile Leu Arg Thr Arg Val Lys Thr Thr Gly Ile 
65                  70                  75                  80  


Val Glu Thr His Phe Thr Phe Lys Asn Leu His Phe Arg Leu Phe Asp 
                85                  90                  95      


Val Gly Gly Gln Arg Ser Glu Arg Lys Lys Trp Ile His Cys Phe Glu 
            100                 105                 110         


Asp Val Thr Ala Ile Ile Phe Cys Val Ala Leu Ser Gly Tyr Asp Gln 
        115                 120                 125             


Val Leu His Glu Asp Glu Thr Thr Asn Arg Met His Glu Ser Leu Met 
    130                 135                 140                 


Leu Phe Asp Ser Ile Cys Asn Asn Lys Phe Phe Ile Asp Thr Ser Ile 
145                 150                 155                 160 


Ile Leu Phe Leu Asn Lys Lys Asp Leu Phe Gly Glu Lys Ile Lys Lys 
                165                 170                 175     


Ser Pro Leu Thr Ile Cys Phe Pro Glu Tyr Thr Gly Pro Asn Thr Tyr 
            180                 185                 190         


Glu Asp Ala Ala Ala Tyr Ile Gln Ala Gln Phe Glu Ser Lys Asn Arg 
        195                 200                 205             


Ser Pro Asn Lys Glu Ile Tyr Cys His Met Thr Cys Ala Thr Asp Thr 
    210                 215                 220                 


Asn Asn Ile Gln Val Val Phe Asp Ala Val Thr Asp Ile Ile Ile Ala 
225                 230                 235                 240 


Asn Asn Leu Arg Gly Cys Gly Leu Tyr 
                245                 


<210>  763
<211>  1734
<212>  DNA
<213>  Homo sapiens

<400>  763
cggtgccaca gggacgaggc ctggagagca gtcgctccta gaaccggggc gcgaagggca       60

cccccgcctc cagcacgcgc cctccgccct cccggcctcg ctccccccgg agtgggggcc      120

tcgccggccc ctggtccccg tcactcagca acgtcgggtc agccttcgcc gggttagtgg      180

cgacgcggcc gcgcgaattc gcacaggggc agtagaatga aagagggcat gtctaataac      240

agcaccacta gcatctccca agccaggaaa gctgtggagc agctaaagat ggaagcctgt      300

atggacaggg tcaaggtctc ccaggcagct gcggacctcc tggcctactg tgaagctcac      360

gtgcgggaag atcctctcat cattccagtg cctgcatcag aaaacccctt tcgcgagaag      420

aagttctttt gtaccattct ctaactccgt gtgtgatgaa aacgcctcct tttctgacct      480

tcaaagtccc ctgtagagac catgcatgct ctaaacctta gggagtgaga ccaacaccca      540

tccctgccca gccagagtgg ccggggcttg tcttatgttt ccatctgttt tcttcgtggc      600

attcaatttc atttttttcc ttttcatttt catgttattt tcattattgg caaagaaaat      660

caaaatgttt atagccaaat aacaaatgtg ccatgtaaaa gtaagtctgg acttaagagt      720

ttaaaatttt taaacatcag tttccaagtt tatatcatat taatacattt cagtggataa      780

tttatttaaa aaaaaaaact atgcctaaat atcccttatt tgcaatattc agtatcaaat      840

tagagcattt tgaccaactg aaacatataa cgttttcatc tcctttcctg gagaaagcag      900

ctgcagaggt tctgtatttc ctgcatttcc atcatcctag taaaaagaca acaacccaca      960

ggattggaat ggttttcttt tgtttttttt ttgttgttgt tgttgttttg agatggagtc     1020

tcgctctgtc acccaggctg gagtgcaatg gcgtgacctc agctcactgc gacctccacc     1080

tcctgggttc aagcgattct cctgcctcag cctcctgagt agctgggatc ataggcacgc     1140

gccaccacac ccagctaatt ttttgtattt ttagtaaaga cggggtttca ccatgttggt     1200

caggctggtc tcaaactcct gacctcgtga tccacccgcc tcggcctccc aaagcgctgg     1260

gattacaggc gtgagccacc acacccggcc gtggaatggt tttcttagca tatcctcctg     1320

gggccgtggc gcccaggctg tgggccgtgg tggatgtccc ttgtttcagt ggtcctacaa     1380

aggtagatgg tgggcggaca ccgaagtcaa cttgactgta aaagtacccc ataccgttga     1440

cgcgctgtgg cagacctgtg ggtgcggtct cccctctcca aatgccacct cttcctgctc     1500

cctcctcttt tggctcctac tcagtagttc cattgtgggc tgcagtaata taaggacctg     1560

ttctggacac agcactgggc ccgctggggt tttagtaggg cagccccttc cctgcaggag     1620

tgaggcatgg tgacagcagt cccctatgtg cccccaagtc atctgagcat tggtgtgcat     1680

taaggtactc aatcttccaa caataaatac cataagtgca aaaaaaaaaa aaaa           1734


<210>  764
<211>  75
<212>  PRT
<213>  Homo sapiens

<400>  764

Met Lys Glu Gly Met Ser Asn Asn Ser Thr Thr Ser Ile Ser Gln Ala 
1               5                   10                  15      


Arg Lys Ala Val Glu Gln Leu Lys Met Glu Ala Cys Met Asp Arg Val 
            20                  25                  30          


Lys Val Ser Gln Ala Ala Ala Asp Leu Leu Ala Tyr Cys Glu Ala His 
        35                  40                  45              


Val Arg Glu Asp Pro Leu Ile Ile Pro Val Pro Ala Ser Glu Asn Pro 
    50                  55                  60                  


Phe Arg Glu Lys Lys Phe Phe Cys Thr Ile Leu 
65                  70                  75  


<210>  765
<211>  75
<212>  PRT
<213>  Homo sapiens

<400>  765

Met Lys Glu Gly Met Ser Asn Asn Ser Thr Thr Ser Ile Ser Gln Ala 
1               5                   10                  15      


Arg Lys Ala Val Glu Gln Leu Lys Met Glu Ala Cys Met Asp Arg Val 
            20                  25                  30          


Lys Val Ser Gln Ala Ala Ala Asp Leu Leu Ala Tyr Cys Glu Ala His 
        35                  40                  45              


Val Arg Glu Asp Pro Leu Ile Ile Pro Val Pro Ala Ser Glu Asn Pro 
    50                  55                  60                  


Phe Arg Glu Lys Lys Phe Phe Cys Thr Ile Leu 
65                  70                  75  


<210>  766
<211>  2958
<212>  DNA
<213>  Homo sapiens

<400>  766
agaagagggc taggctgaga gggaagccag gactgtagga gagggaggca gcccgtcctc       60

ctcacgaacc tgcaaggatg cggcaggggc ctgggggcat ggggaggtac taaccccccg      120

gagcccccga ttggggcttg cagacctggc ccgtgggcgg attttctgcc tagcgcagcc      180

gagaagcaga ggtgccagga aaaccaagag aggggcgctg ggggtgccca tccccagagt      240

cggtccctct gcgaaccgag gaagaaaaga ggagggagtc agcgagtggt cagaagggaa      300

aacctgacac cagactggct ccggagcgtc cgggagactg gggcgctccg cgccatcgtc      360

ttcaatgctt ctctgaacag cctttaggaa gagtgcgaga gaaagagaga gagcgcgcgc      420

cagggagagg agaaaagaag atgaggatta tttccagaca gattgtcttg ttattttctg      480

gattttgggg actcgccatg ggagcctttc cgagcagcgt gcaaataggt ggtctcttca      540

tccgaaacac agatcaggaa tacactgctt ttcgattagc aatttttctt cataacacca      600

gccccaatgc gtcggaagct ccttttaatt tggtacctca tgtggacaac attgagacag      660

ccaacagttt tgctgtaaca aacgccttct gttcccagta ttctagagga gtatttgcca      720

tttttggact ctatgataag aggtcggtac ataccttgac ctcattctgc agcgccttac      780

atatctccct catcacacca agtttcccta ctgaggggga gagccagttt gtgctgcaac      840

taagaccttc gttacgagga gcactcttga gtttgctgga tcactacgaa tggaactgtt      900

ttgtcttcct gtatgacaca gacaggggat actcgatact ccaagctatt atggaaaaag      960

caggacaaaa tggttggcat gtcagcgcta tatgtgtgga aaattttaat gatgtcagct     1020

ataggcaact tctagaagaa cttgacagaa gacaagagaa gaagtttgta atagactgtg     1080

agatagagag acttcaaaac atattagaac agattgtaag tgttggaaag catgttaaag     1140

gctaccatta tatcattgca aacttgggat tcaaggatat ttctcttgag aggtttatac     1200

atggtggagc caatgttact ggattccagt tggtggattt taatacacct atggtaatca     1260

aactaatgga tcgctggaag aaactagatc agagagagta tccaggatct gagactcctc     1320

caaagtacac ctctgctctg acttatgatg gagtccttgt gatggctgaa actttccgaa     1380

gtcttaggag gcagaaaatt gatatctcaa ggagaggaaa tgctggggat tgtctggcaa     1440

atcctgctgc tccatggggc cagggaattg acatggagag gacactcaaa caggttcgaa     1500

ttcaagggct gacagggaat gttcagtttg accactatgg acgtagagtc aattacacaa     1560

tggatgtgtt tgagctgaaa agcacaggac ctagaaaggt tggttactgg aatgatatgg     1620

ataagttagt cttgattcaa gatgtaccaa ctcttggcaa tgacacagct gctattgaga     1680

acagaacagt ggttgtaacc acaattatgc ctctgatgaa gaatcctatt ttaagaaatt     1740

gatcaagaaa gaaaagagtt ccgcgctgtt cgaccattcc taactaaggc tcaagtcttg     1800

ttctccagtg tagtaaattt aagcttattt ttcatgtggg attcttcttg gatgaccaac     1860

tctggactac cagaaaaaaa aaattttaag ttctgtgact tttctgagat actagaacaa     1920

aagaagaatt aatcttcatc tttctcaaga aatagatgtt gacaaagaat cacttagcga     1980

ttctgacata tcaattcccc tatcttgaaa tgaggtcact gtatgtaaat gatggaatta     2040

tatcactcca tttccaaggg tagattttct ataagtaaat atctcggaat ttgtgtgctt     2100

gttttctgaa tatatacagt tgttttcttt aaagatctct tggaattttg cctgttctgt     2160

gtgaaataaa gtgttttaat gtgcattata ggtatgatat agagaatctc ctttccatcc     2220

ttgttactaa agggactgga caaataaatc ttaaaaccaa aatactgaat taattttgca     2280

agcatggcta gtttttagga agcatgctat caaaaaaaaa aagactaaaa atgactgaaa     2340

aaatccaact gttttatata tatataaata tatatatatt tatatatata tataaaggat     2400

attctgtaaa gttatatgtt gtttgacagt aaagccatca atatttttgc tatcaaaata     2460

gtataatact agtatctttt tgtatgaaaa tgtaatcttt atataaataa tacctctgat     2520

atttgcaact gcataatcgt tcagtaattc aaaaagacat actagaatcc tttttctgaa     2580

agtgttcctt caatttgctt ttgttgaaaa cggtagtcca ggacctatga tatccctcca     2640

cttcattcat tatgaaagaa atcccttgta gataaacaag atattggcat ctgcatgtaa     2700

ttatccccag attcagctga aaactcccaa cacagatgga attggctaga cattttaata     2760

tatgtgatac ctatatctag atatagaagg ctgagagtga gcactggata taattcattt     2820

tgattgaaat tgatatggtg ttattgttct tccagttgtc tgtcctttgt gtatgttctt     2880

atttatatgt tgatacactg taacactata tgctattgct aaataaaatt gattgagaaa     2940

ttcaaaaaaa aaaaaaaa                                                   2958


<210>  767
<211>  902
<212>  PRT
<213>  Homo sapiens

<400>  767

Met Arg Ile Ile Ser Arg Gln Ile Val Leu Leu Phe Ser Gly Phe Trp 
1               5                   10                  15      


Gly Leu Ala Met Gly Ala Phe Pro Ser Ser Val Gln Ile Gly Gly Leu 
            20                  25                  30          


Phe Ile Arg Asn Thr Asp Gln Glu Tyr Thr Ala Phe Arg Leu Ala Ile 
        35                  40                  45              


Phe Leu His Asn Thr Ser Pro Asn Ala Ser Glu Ala Pro Phe Asn Leu 
    50                  55                  60                  


Val Pro His Val Asp Asn Ile Glu Thr Ala Asn Ser Phe Ala Val Thr 
65                  70                  75                  80  


Asn Ala Phe Cys Ser Gln Tyr Ser Arg Gly Val Phe Ala Ile Phe Gly 
                85                  90                  95      


Leu Tyr Asp Lys Arg Ser Val His Thr Leu Thr Ser Phe Cys Ser Ala 
            100                 105                 110         


Leu His Ile Ser Leu Ile Thr Pro Ser Phe Pro Thr Glu Gly Glu Ser 
        115                 120                 125             


Gln Phe Val Leu Gln Leu Arg Pro Ser Leu Arg Gly Ala Leu Leu Ser 
    130                 135                 140                 


Leu Leu Asp His Tyr Glu Trp Asn Cys Phe Val Phe Leu Tyr Asp Thr 
145                 150                 155                 160 


Asp Arg Gly Tyr Ser Ile Leu Gln Ala Ile Met Glu Lys Ala Gly Gln 
                165                 170                 175     


Asn Gly Trp His Val Ser Ala Ile Cys Val Glu Asn Phe Asn Asp Val 
            180                 185                 190         


Ser Tyr Arg Gln Leu Leu Glu Glu Leu Asp Arg Arg Gln Glu Lys Lys 
        195                 200                 205             


Phe Val Ile Asp Cys Glu Ile Glu Arg Leu Gln Asn Ile Leu Glu Gln 
    210                 215                 220                 


Ile Val Ser Val Gly Lys His Val Lys Gly Tyr His Tyr Ile Ile Ala 
225                 230                 235                 240 


Asn Leu Gly Phe Lys Asp Ile Ser Leu Glu Arg Phe Ile His Gly Gly 
                245                 250                 255     


Ala Asn Val Thr Gly Phe Gln Leu Val Asp Phe Asn Thr Pro Met Val 
            260                 265                 270         


Ile Lys Leu Met Asp Arg Trp Lys Lys Leu Asp Gln Arg Glu Tyr Pro 
        275                 280                 285             


Gly Ser Glu Thr Pro Pro Lys Tyr Thr Ser Ala Leu Thr Tyr Asp Gly 
    290                 295                 300                 


Val Leu Val Met Ala Glu Thr Phe Arg Ser Leu Arg Arg Gln Lys Ile 
305                 310                 315                 320 


Asp Ile Ser Arg Arg Gly Asn Ala Gly Asp Cys Leu Ala Asn Pro Ala 
                325                 330                 335     


Ala Pro Trp Gly Gln Gly Ile Asp Met Glu Arg Thr Leu Lys Gln Val 
            340                 345                 350         


Arg Ile Gln Gly Leu Thr Gly Asn Val Gln Phe Asp His Tyr Gly Arg 
        355                 360                 365             


Arg Val Asn Tyr Thr Met Asp Val Phe Glu Leu Lys Ser Thr Gly Pro 
    370                 375                 380                 


Arg Lys Val Gly Tyr Trp Asn Asp Met Asp Lys Leu Val Leu Ile Gln 
385                 390                 395                 400 


Asp Val Pro Thr Leu Gly Asn Asp Thr Ala Ala Ile Glu Asn Arg Thr 
                405                 410                 415     


Val Val Val Thr Thr Ile Met Glu Ser Pro Tyr Val Met Tyr Lys Lys 
            420                 425                 430         


Asn His Glu Met Phe Glu Gly Asn Asp Lys Tyr Glu Gly Tyr Cys Val 
        435                 440                 445             


Asp Leu Ala Ser Glu Ile Ala Lys His Ile Gly Ile Lys Tyr Lys Ile 
    450                 455                 460                 


Ala Ile Val Pro Asp Gly Lys Tyr Gly Ala Arg Asp Ala Asp Thr Lys 
465                 470                 475                 480 


Ile Trp Asn Gly Met Val Gly Glu Leu Val Tyr Gly Lys Ala Glu Ile 
                485                 490                 495     


Ala Ile Ala Pro Leu Thr Ile Thr Leu Val Arg Glu Glu Val Ile Asp 
            500                 505                 510         


Phe Ser Lys Pro Phe Met Ser Leu Gly Ile Ser Ile Met Ile Lys Lys 
        515                 520                 525             


Pro Gln Lys Ser Lys Pro Gly Val Phe Ser Phe Leu Asp Pro Leu Ala 
    530                 535                 540                 


Tyr Glu Ile Trp Met Cys Ile Val Phe Ala Tyr Ile Gly Val Ser Val 
545                 550                 555                 560 


Val Leu Phe Leu Val Ser Arg Phe Ser Pro Tyr Glu Trp His Thr Glu 
                565                 570                 575     


Glu Pro Glu Asp Gly Lys Glu Gly Pro Ser Asp Gln Pro Pro Asn Glu 
            580                 585                 590         


Phe Gly Ile Phe Asn Ser Leu Trp Phe Ser Leu Gly Ala Phe Met Gln 
        595                 600                 605             


Gln Gly Cys Asp Ile Ser Pro Arg Ser Leu Ser Gly Arg Ile Val Gly 
    610                 615                 620                 


Gly Val Trp Trp Phe Phe Thr Leu Ile Ile Ile Ser Ser Tyr Thr Ala 
625                 630                 635                 640 


Asn Leu Ala Ala Phe Leu Thr Val Glu Arg Met Val Ser Pro Ile Glu 
                645                 650                 655     


Ser Ala Glu Asp Leu Ala Lys Gln Thr Glu Ile Ala Tyr Gly Thr Leu 
            660                 665                 670         


Asp Ser Gly Ser Thr Lys Glu Phe Phe Arg Arg Ser Lys Ile Ala Val 
        675                 680                 685             


Tyr Glu Lys Met Trp Thr Tyr Met Arg Ser Ala Glu Pro Ser Val Phe 
    690                 695                 700                 


Thr Arg Thr Thr Ala Glu Gly Val Ala Arg Val Arg Lys Ser Lys Gly 
705                 710                 715                 720 


Lys Phe Ala Phe Leu Leu Glu Ser Thr Met Asn Glu Tyr Ile Glu Gln 
                725                 730                 735     


Arg Lys Pro Cys Asp Thr Met Lys Val Gly Gly Asn Leu Asp Ser Lys 
            740                 745                 750         


Gly Tyr Gly Val Ala Thr Pro Lys Gly Ser Ser Leu Arg Thr Pro Val 
        755                 760                 765             


Asn Leu Ala Val Leu Lys Leu Ser Glu Ala Gly Val Leu Asp Lys Leu 
    770                 775                 780                 


Lys Asn Lys Trp Trp Tyr Asp Lys Gly Glu Cys Gly Pro Lys Asp Ser 
785                 790                 795                 800 


Gly Ser Lys Asp Lys Thr Ser Ala Leu Ser Leu Ser Asn Val Ala Gly 
                805                 810                 815     


Val Phe Tyr Ile Leu Val Gly Gly Leu Gly Leu Ala Met Leu Val Ala 
            820                 825                 830         


Leu Ile Glu Phe Cys Tyr Lys Ser Arg Ala Glu Ala Lys Arg Met Lys 
        835                 840                 845             


Leu Thr Phe Ser Glu Ala Ile Arg Asn Lys Ala Arg Leu Ser Ile Thr 
    850                 855                 860                 


Gly Ser Val Gly Glu Asn Gly Arg Val Leu Thr Pro Asp Cys Pro Lys 
865                 870                 875                 880 


Ala Val His Thr Gly Thr Ala Ile Arg Gln Ser Ser Gly Leu Ala Val 
                885                 890                 895     


Ile Ala Ser Asp Leu Pro 
            900         


<210>  768
<211>  433
<212>  PRT
<213>  Homo sapiens

<400>  768

Met Arg Ile Ile Ser Arg Gln Ile Val Leu Leu Phe Ser Gly Phe Trp 
1               5                   10                  15      


Gly Leu Ala Met Gly Ala Phe Pro Ser Ser Val Gln Ile Gly Gly Leu 
            20                  25                  30          


Phe Ile Arg Asn Thr Asp Gln Glu Tyr Thr Ala Phe Arg Leu Ala Ile 
        35                  40                  45              


Phe Leu His Asn Thr Ser Pro Asn Ala Ser Glu Ala Pro Phe Asn Leu 
    50                  55                  60                  


Val Pro His Val Asp Asn Ile Glu Thr Ala Asn Ser Phe Ala Val Thr 
65                  70                  75                  80  


Asn Ala Phe Cys Ser Gln Tyr Ser Arg Gly Val Phe Ala Ile Phe Gly 
                85                  90                  95      


Leu Tyr Asp Lys Arg Ser Val His Thr Leu Thr Ser Phe Cys Ser Ala 
            100                 105                 110         


Leu His Ile Ser Leu Ile Thr Pro Ser Phe Pro Thr Glu Gly Glu Ser 
        115                 120                 125             


Gln Phe Val Leu Gln Leu Arg Pro Ser Leu Arg Gly Ala Leu Leu Ser 
    130                 135                 140                 


Leu Leu Asp His Tyr Glu Trp Asn Cys Phe Val Phe Leu Tyr Asp Thr 
145                 150                 155                 160 


Asp Arg Gly Tyr Ser Ile Leu Gln Ala Ile Met Glu Lys Ala Gly Gln 
                165                 170                 175     


Asn Gly Trp His Val Ser Ala Ile Cys Val Glu Asn Phe Asn Asp Val 
            180                 185                 190         


Ser Tyr Arg Gln Leu Leu Glu Glu Leu Asp Arg Arg Gln Glu Lys Lys 
        195                 200                 205             


Phe Val Ile Asp Cys Glu Ile Glu Arg Leu Gln Asn Ile Leu Glu Gln 
    210                 215                 220                 


Ile Val Ser Val Gly Lys His Val Lys Gly Tyr His Tyr Ile Ile Ala 
225                 230                 235                 240 


Asn Leu Gly Phe Lys Asp Ile Ser Leu Glu Arg Phe Ile His Gly Gly 
                245                 250                 255     


Ala Asn Val Thr Gly Phe Gln Leu Val Asp Phe Asn Thr Pro Met Val 
            260                 265                 270         


Ile Lys Leu Met Asp Arg Trp Lys Lys Leu Asp Gln Arg Glu Tyr Pro 
        275                 280                 285             


Gly Ser Glu Thr Pro Pro Lys Tyr Thr Ser Ala Leu Thr Tyr Asp Gly 
    290                 295                 300                 


Val Leu Val Met Ala Glu Thr Phe Arg Ser Leu Arg Arg Gln Lys Ile 
305                 310                 315                 320 


Asp Ile Ser Arg Arg Gly Asn Ala Gly Asp Cys Leu Ala Asn Pro Ala 
                325                 330                 335     


Ala Pro Trp Gly Gln Gly Ile Asp Met Glu Arg Thr Leu Lys Gln Val 
            340                 345                 350         


Arg Ile Gln Gly Leu Thr Gly Asn Val Gln Phe Asp His Tyr Gly Arg 
        355                 360                 365             


Arg Val Asn Tyr Thr Met Asp Val Phe Glu Leu Lys Ser Thr Gly Pro 
    370                 375                 380                 


Arg Lys Val Gly Tyr Trp Asn Asp Met Asp Lys Leu Val Leu Ile Gln 
385                 390                 395                 400 


Asp Val Pro Thr Leu Gly Asn Asp Thr Ala Ala Ile Glu Asn Arg Thr 
                405                 410                 415     


Val Val Val Thr Thr Ile Met Pro Leu Met Lys Asn Pro Ile Leu Arg 
            420                 425                 430         


Asn 
    


<210>  769
<211>  2575
<212>  DNA
<213>  Homo sapiens

<400>  769
gggacacaga gggaggaaga agcggcggcg gcggcggcgg cggcggcggc tcctctttgc       60

agagggggaa actcttgggc tgagagcagg aataatgcgg taggcaaggc gggctgctgg      120

ctcccccggc tccggcagca gcggcggcag cccgagcagc ggcagcagca gcggcagcac      180

cccaggcgct gacagccccg ccggccggct ccgttgctga ccgccgactg tcaatggagc      240

tggaaaacat cgtggccaac acggtcttgc tgaaagccag ggaagggggc ggaggaaagc      300

gcaaagggaa aagcaagaag tggaaagaaa tcctgaagtt ccctcacatt agccagtgtg      360

aagacctccg aaggaccata gacagagatt actgcagttt atgtgacaag cagccaatcg      420

ggaggctgct tttccggcag ttttgtgaaa ccaggcctgg gctggagtgt tacattcagt      480

tcctggactc cgtggcagaa tatgaagtta ctccagatga aaaactggga gagaaaggga      540

aggaaattat gaccaagtac ctcaccccaa agtcccctgt tttcatagcc caagttggcc      600

aagacctggt ctcccagacg gaggagaagc tcctacagaa gccgtgcaaa gaactctttt      660

ctgcctgtgc acagtctgtc cacgagtacc tgaggggaga accattccac gaatatctgg      720

acagcatgtt ttttgaccgc tttctccagt ggaagtggtt ggaaaggcaa ccggtgacca      780

aaaacacttt caggcagtat cgagtgctag gaaaaggggg cttcggggag gtctgtgcct      840

gccaggttcg ggccacgggt aaaatgtatg cctgcaagcg cttggagaag aagaggatca      900

aaaagaggaa aggggagtcc atggccctca atgagaagca gatcctcgag aaggtcaaca      960

gtcagtttgt ggtcaacctg gcctatgcct acgagaccaa ggatgcactg tgcttggtcc     1020

tgaccatcat gaatgggggt gacctgaagt tccacatcta caacatgggc aaccctggct     1080

tcgaggagga gcgggccttg ttttatgcgg cagagatcct ctgcggctta gaagacctcc     1140

accgtgagaa caccgtctac cgagatctga aacctgaaaa catcctgtta gatgattatg     1200

gccacattag gatctcagac ctgggcttgg ctgtgaagat ccccgaggga gacctgatcc     1260

gcggccgggt gggcactgtt ggctacatgg ctccagaggt cctgaacaac cagaggtacg     1320

gcctgagccc cgactactgg ggccttggct gcctcatcta tgagatgatc gagggccagt     1380

cgccgttccg cggccgcaag gagaaggtga agcgggagga ggtggaccgc cgggtcctgg     1440

agacggagga ggtgtactcc cacaagttct ccgaggaggc caagtccatc tgcaagatgc     1500

tgctcacgaa agatgcgaag cagaggctgg gctgccagga ggagggggct gcagaggtca     1560

agagacaccc cttcttcagg aacatgaact tcaagcgctt agaagccggg atgttggacc     1620

ctcccttcgt tccagacccc cgcgctgtgt actgtaagga cgtgctggac atcgagcagt     1680

tctccactgt gaagggcgtc aatctggacc acacagacga cgacttctac tccaagttct     1740

ccacgggctc tgtgtccatc ccatggcaaa acgagatgat agaaacagaa tgctttaagg     1800

agctgaacgt gtttggacct aatggtaccc tcccgccaga tctgaacaga aaccaccctc     1860

cggaaccgcc caagaaaggg ctgctccaga gactcttcaa gcggcagcat cagaacaatt     1920

ccaagagttc gcccagctcc aagaccagtt ttaaccacca cataaactca aaccatgtca     1980

gctcgaactc caccggaagc agctagtttc ggctctggcc tccaagtcca cagtggaacc     2040

agcccagacc cttctcctta gaagtggaag tagtggagcc cctgctctgg tggggctgcc     2100

aggggagacc ccgggagccg gggaaggagg ccgtccatcc cgtcgacgta gaacctcgag     2160

gtttctcaaa gaaatttcca ctcaggtctg ttttccgagg cggccccggc cggggtggat     2220

tggatttgtc tttggtgaac attgcaatag aaatccaatt ggatacgaca acttgcacgt     2280

attttaatag cgtcataact agaactgaat tttgtcttta tgatttttaa agaaaagttt     2340

tgtaaatttc tctactgtct cagtttacat tttgtatatt tgtatttaaa tgaaagtgag     2400

actttgaggg tgtatatttt ctgtgcagcc actgttaagc catgtgttcc aaggcatttt     2460

agcggggagg gggttatcaa aaaaaaaaaa atgtgactca agacttccag agcctcaaat     2520

gagaaaatgt ctttattaaa tgtagaaagt gatccataaa aaaaaaaaaa aaaaa          2575


<210>  770
<211>  590
<212>  PRT
<213>  Homo sapiens

<400>  770

Met Glu Leu Glu Asn Ile Val Ala Asn Thr Val Leu Leu Lys Ala Arg 
1               5                   10                  15      


Glu Gly Gly Gly Gly Lys Arg Lys Gly Lys Ser Lys Lys Trp Lys Glu 
            20                  25                  30          


Ile Leu Lys Phe Pro His Ile Ser Gln Cys Glu Asp Leu Arg Arg Thr 
        35                  40                  45              


Ile Asp Arg Asp Tyr Cys Ser Leu Cys Asp Lys Gln Pro Ile Gly Arg 
    50                  55                  60                  


Leu Leu Phe Arg Gln Phe Cys Glu Thr Arg Pro Gly Leu Glu Cys Tyr 
65                  70                  75                  80  


Ile Gln Phe Leu Asp Ser Val Ala Glu Tyr Glu Val Thr Pro Asp Glu 
                85                  90                  95      


Lys Leu Gly Glu Lys Gly Lys Glu Ile Met Thr Lys Tyr Leu Thr Pro 
            100                 105                 110         


Lys Ser Pro Val Phe Ile Ala Gln Val Gly Gln Asp Leu Val Ser Gln 
        115                 120                 125             


Thr Glu Glu Lys Leu Leu Gln Lys Pro Cys Lys Glu Leu Phe Ser Ala 
    130                 135                 140                 


Cys Ala Gln Ser Val His Glu Tyr Leu Arg Gly Glu Pro Phe His Glu 
145                 150                 155                 160 


Tyr Leu Asp Ser Met Phe Phe Asp Arg Phe Leu Gln Trp Lys Trp Leu 
                165                 170                 175     


Glu Arg Gln Pro Val Thr Lys Asn Thr Phe Arg Gln Tyr Arg Val Leu 
            180                 185                 190         


Gly Lys Gly Gly Phe Gly Glu Val Cys Ala Cys Gln Val Arg Ala Thr 
        195                 200                 205             


Gly Lys Met Tyr Ala Cys Lys Arg Leu Glu Lys Lys Arg Ile Lys Lys 
    210                 215                 220                 


Arg Lys Gly Glu Ser Met Ala Leu Asn Glu Lys Gln Ile Leu Glu Lys 
225                 230                 235                 240 


Val Asn Ser Gln Phe Val Val Asn Leu Ala Tyr Ala Tyr Glu Thr Lys 
                245                 250                 255     


Asp Ala Leu Cys Leu Val Leu Thr Ile Met Asn Gly Gly Asp Leu Lys 
            260                 265                 270         


Phe His Ile Tyr Asn Met Gly Asn Pro Gly Phe Glu Glu Glu Arg Ala 
        275                 280                 285             


Leu Phe Tyr Ala Ala Glu Ile Leu Cys Gly Leu Glu Asp Leu His Arg 
    290                 295                 300                 


Glu Asn Thr Val Tyr Arg Asp Leu Lys Pro Glu Asn Ile Leu Leu Asp 
305                 310                 315                 320 


Asp Tyr Gly His Ile Arg Ile Ser Asp Leu Gly Leu Ala Val Lys Ile 
                325                 330                 335     


Pro Glu Gly Asp Leu Ile Arg Gly Arg Val Gly Thr Val Gly Tyr Met 
            340                 345                 350         


Ala Pro Glu Val Leu Asn Asn Gln Arg Tyr Gly Leu Ser Pro Asp Tyr 
        355                 360                 365             


Trp Gly Leu Gly Cys Leu Ile Tyr Glu Met Ile Glu Gly Gln Ser Pro 
    370                 375                 380                 


Phe Arg Gly Arg Lys Glu Lys Val Lys Arg Glu Glu Val Asp Arg Arg 
385                 390                 395                 400 


Val Leu Glu Thr Glu Glu Val Tyr Ser His Lys Phe Ser Glu Glu Ala 
                405                 410                 415     


Lys Ser Ile Cys Lys Met Leu Leu Thr Lys Asp Ala Lys Gln Arg Leu 
            420                 425                 430         


Gly Cys Gln Glu Glu Gly Ala Ala Glu Val Lys Arg His Pro Phe Phe 
        435                 440                 445             


Arg Asn Met Asn Phe Lys Arg Leu Glu Ala Gly Met Leu Asp Pro Pro 
    450                 455                 460                 


Phe Val Pro Asp Pro Arg Ala Val Tyr Cys Lys Asp Val Leu Asp Ile 
465                 470                 475                 480 


Glu Gln Phe Ser Thr Val Lys Gly Val Asn Leu Asp His Thr Asp Asp 
                485                 490                 495     


Asp Phe Tyr Ser Lys Phe Ser Thr Gly Ser Val Ser Ile Pro Trp Gln 
            500                 505                 510         


Asn Glu Met Ile Glu Thr Glu Cys Phe Lys Glu Leu Asn Val Phe Gly 
        515                 520                 525             


Pro Asn Gly Thr Leu Pro Pro Asp Leu Asn Arg Asn His Pro Pro Glu 
    530                 535                 540                 


Pro Pro Lys Lys Gly Leu Leu Gln Arg Leu Phe Lys Arg Gln His Gln 
545                 550                 555                 560 


Asn Asn Ser Lys Ser Ser Pro Ser Ser Lys Thr Ser Phe Asn His His 
                565                 570                 575     


Ile Asn Ser Asn His Val Ser Ser Asn Ser Thr Gly Ser Ser 
            580                 585                 590 


<210>  771
<211>  590
<212>  PRT
<213>  Homo sapiens

<400>  771

Met Glu Leu Glu Asn Ile Val Ala Asn Thr Val Leu Leu Lys Ala Arg 
1               5                   10                  15      


Glu Gly Gly Gly Gly Lys Arg Lys Gly Lys Ser Lys Lys Trp Lys Glu 
            20                  25                  30          


Ile Leu Lys Phe Pro His Ile Ser Gln Cys Glu Asp Leu Arg Arg Thr 
        35                  40                  45              


Ile Asp Arg Asp Tyr Cys Ser Leu Cys Asp Lys Gln Pro Ile Gly Arg 
    50                  55                  60                  


Leu Leu Phe Arg Gln Phe Cys Glu Thr Arg Pro Gly Leu Glu Cys Tyr 
65                  70                  75                  80  


Ile Gln Phe Leu Asp Ser Val Ala Glu Tyr Glu Val Thr Pro Asp Glu 
                85                  90                  95      


Lys Leu Gly Glu Lys Gly Lys Glu Ile Met Thr Lys Tyr Leu Thr Pro 
            100                 105                 110         


Lys Ser Pro Val Phe Ile Ala Gln Val Gly Gln Asp Leu Val Ser Gln 
        115                 120                 125             


Thr Glu Glu Lys Leu Leu Gln Lys Pro Cys Lys Glu Leu Phe Ser Ala 
    130                 135                 140                 


Cys Ala Gln Ser Val His Glu Tyr Leu Arg Gly Glu Pro Phe His Glu 
145                 150                 155                 160 


Tyr Leu Asp Ser Met Phe Phe Asp Arg Phe Leu Gln Trp Lys Trp Leu 
                165                 170                 175     


Glu Arg Gln Pro Val Thr Lys Asn Thr Phe Arg Gln Tyr Arg Val Leu 
            180                 185                 190         


Gly Lys Gly Gly Phe Gly Glu Val Cys Ala Cys Gln Val Arg Ala Thr 
        195                 200                 205             


Gly Lys Met Tyr Ala Cys Lys Arg Leu Glu Lys Lys Arg Ile Lys Lys 
    210                 215                 220                 


Arg Lys Gly Glu Ser Met Ala Leu Asn Glu Lys Gln Ile Leu Glu Lys 
225                 230                 235                 240 


Val Asn Ser Gln Phe Val Val Asn Leu Ala Tyr Ala Tyr Glu Thr Lys 
                245                 250                 255     


Asp Ala Leu Cys Leu Val Leu Thr Ile Met Asn Gly Gly Asp Leu Lys 
            260                 265                 270         


Phe His Ile Tyr Asn Met Gly Asn Pro Gly Phe Glu Glu Glu Arg Ala 
        275                 280                 285             


Leu Phe Tyr Ala Ala Glu Ile Leu Cys Gly Leu Glu Asp Leu His Arg 
    290                 295                 300                 


Glu Asn Thr Val Tyr Arg Asp Leu Lys Pro Glu Asn Ile Leu Leu Asp 
305                 310                 315                 320 


Asp Tyr Gly His Ile Arg Ile Ser Asp Leu Gly Leu Ala Val Lys Ile 
                325                 330                 335     


Pro Glu Gly Asp Leu Ile Arg Gly Arg Val Gly Thr Val Gly Tyr Met 
            340                 345                 350         


Ala Pro Glu Val Leu Asn Asn Gln Arg Tyr Gly Leu Ser Pro Asp Tyr 
        355                 360                 365             


Trp Gly Leu Gly Cys Leu Ile Tyr Glu Met Ile Glu Gly Gln Ser Pro 
    370                 375                 380                 


Phe Arg Gly Arg Lys Glu Lys Val Lys Arg Glu Glu Val Asp Arg Arg 
385                 390                 395                 400 


Val Leu Glu Thr Glu Glu Val Tyr Ser His Lys Phe Ser Glu Glu Ala 
                405                 410                 415     


Lys Ser Ile Cys Lys Met Leu Leu Thr Lys Asp Ala Lys Gln Arg Leu 
            420                 425                 430         


Gly Cys Gln Glu Glu Gly Ala Ala Glu Val Lys Arg His Pro Phe Phe 
        435                 440                 445             


Arg Asn Met Asn Phe Lys Arg Leu Glu Ala Gly Met Leu Asp Pro Pro 
    450                 455                 460                 


Phe Val Pro Asp Pro Arg Ala Val Tyr Cys Lys Asp Val Leu Asp Ile 
465                 470                 475                 480 


Glu Gln Phe Ser Thr Val Lys Gly Val Asn Leu Asp His Thr Asp Asp 
                485                 490                 495     


Asp Phe Tyr Ser Lys Phe Ser Thr Gly Ser Val Ser Ile Pro Trp Gln 
            500                 505                 510         


Asn Glu Met Ile Glu Thr Glu Cys Phe Lys Glu Leu Asn Val Phe Gly 
        515                 520                 525             


Pro Asn Gly Thr Leu Pro Pro Asp Leu Asn Arg Asn His Pro Pro Glu 
    530                 535                 540                 


Pro Pro Lys Lys Gly Leu Leu Gln Arg Leu Phe Lys Arg Gln His Gln 
545                 550                 555                 560 


Asn Asn Ser Lys Ser Ser Pro Ser Ser Lys Thr Ser Phe Asn His His 
                565                 570                 575     


Ile Asn Ser Asn His Val Ser Ser Asn Ser Thr Gly Ser Ser 
            580                 585                 590 


<210>  772
<211>  1229
<212>  DNA
<213>  Homo sapiens

<400>  772
ggaggggcat ggagccgccg cgggcctgct gagctccgga gcgcggcagc cggcggcacg       60

atgccggtgc agctgacgac agccctgcgt gtggtgggca ccagcctgtt tgccctggca      120

gtgctgggtg gcatcctggc agcctatgtg acgggctacc agttcatcca cacggaaaag      180

cactacctgt ccttcggcct gtacggcgcc atcctgggcc tgcacctgct cattcagagc      240

ctttttgcct tcctggagca ccggcgcatg cgacgtgccg gccaggccct gaagctgccc      300

tccccgcggc ggggctcggt ggcactgtgc attgccgcat accaggagga ccctgactac      360

ttgcgcaagt gcctgcgctc ggcccagcgc atctccttcc ctgacctcaa ggtggtcatg      420

gtggtggatg gcaaccgcca ggaggacgcc tacatgctgg acatcttcca cgaggtgctg      480

ggcggcaccg agcaggccgg cttctttgtg tggcgcagca acttccatga ggcaggcgag      540

ggtgagacgg aggccagcct gcaggagggc atggaccgtg tgcgggatgt ggtgcgggcc      600

agcaccttct cgtgcatcat gcagaagtgg ggaggcaagc gcgaggtcat gtacacggcc      660

ttcaaggccc tcggcgattc ggtggactac atccaggtgt gcgactctga cactgtgctg      720

gatccagcct gcaccatcga gatgcttcga gtcctggagg aggatcccca agtaggggga      780

gtcgggggag atgtccagcc cccagggaaa ggtatggcag tagaggatga ccaggtccaa      840

gctgcccagg tcagagctac ggaagcatgg tccgttcacc aacgccacgt ttctagagag      900

cagtgagctg attctccaat ggtgagcagg ggactacatg tgaactggga cctgcaggcc      960

aatgtatccc tgaggaaaag tccacaagaa caattcaaga aactagtaag aaacaatggg     1020

cagaaagctg tgggacgaaa gcacagcagg cttctgggag gctggagatc ctttctctca     1080

agggcaggat tattcccacc tgccacagtt cacatgccac aaataacatc tcaccttcag     1140

tcaagaaaaa cgcaaaggaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa     1200

aaaaaaaaaa aaaaaaaaaa aaaaaaaaa                                       1229


<210>  773
<211>  553
<212>  PRT
<213>  Homo sapiens

<400>  773

Met Pro Val Gln Leu Thr Thr Ala Leu Arg Val Val Gly Thr Ser Leu 
1               5                   10                  15      


Phe Ala Leu Ala Val Leu Gly Gly Ile Leu Ala Ala Tyr Val Thr Gly 
            20                  25                  30          


Tyr Gln Phe Ile His Thr Glu Lys His Tyr Leu Ser Phe Gly Leu Tyr 
        35                  40                  45              


Gly Ala Ile Leu Gly Leu His Leu Leu Ile Gln Ser Leu Phe Ala Phe 
    50                  55                  60                  


Leu Glu His Arg Arg Met Arg Arg Ala Gly Gln Ala Leu Lys Leu Pro 
65                  70                  75                  80  


Ser Pro Arg Arg Gly Ser Val Ala Leu Cys Ile Ala Ala Tyr Gln Glu 
                85                  90                  95      


Asp Pro Asp Tyr Leu Arg Lys Cys Leu Arg Ser Ala Gln Arg Ile Ser 
            100                 105                 110         


Phe Pro Asp Leu Lys Val Val Met Val Val Asp Gly Asn Arg Gln Glu 
        115                 120                 125             


Asp Ala Tyr Met Leu Asp Ile Phe His Glu Val Leu Gly Gly Thr Glu 
    130                 135                 140                 


Gln Ala Gly Phe Phe Val Trp Arg Ser Asn Phe His Glu Ala Gly Glu 
145                 150                 155                 160 


Gly Glu Thr Glu Ala Ser Leu Gln Glu Gly Met Asp Arg Val Arg Asp 
                165                 170                 175     


Val Val Arg Ala Ser Thr Phe Ser Cys Ile Met Gln Lys Trp Gly Gly 
            180                 185                 190         


Lys Arg Glu Val Met Tyr Thr Ala Phe Lys Ala Leu Gly Asp Ser Val 
        195                 200                 205             


Asp Tyr Ile Gln Val Cys Asp Ser Asp Thr Val Leu Asp Pro Ala Cys 
    210                 215                 220                 


Thr Ile Glu Met Leu Arg Val Leu Glu Glu Asp Pro Gln Val Gly Gly 
225                 230                 235                 240 


Val Gly Gly Asp Val Gln Ile Leu Asn Lys Tyr Asp Ser Trp Ile Ser 
                245                 250                 255     


Phe Leu Ser Ser Val Arg Tyr Trp Met Ala Phe Asn Val Glu Arg Ala 
            260                 265                 270         


Cys Gln Ser Tyr Phe Gly Cys Val Gln Cys Ile Ser Gly Pro Leu Gly 
        275                 280                 285             


Met Tyr Arg Asn Ser Leu Leu Gln Gln Phe Leu Glu Asp Trp Tyr His 
    290                 295                 300                 


Gln Lys Phe Leu Gly Ser Lys Cys Ser Phe Gly Asp Asp Arg His Leu 
305                 310                 315                 320 


Thr Asn Arg Val Leu Ser Leu Gly Tyr Arg Thr Lys Tyr Thr Ala Arg 
                325                 330                 335     


Ser Lys Cys Leu Thr Glu Thr Pro Thr Lys Tyr Leu Arg Trp Leu Asn 
            340                 345                 350         


Gln Gln Thr Arg Trp Ser Lys Ser Tyr Phe Arg Glu Trp Leu Tyr Asn 
        355                 360                 365             


Ser Leu Trp Phe His Lys His His Leu Trp Met Thr Tyr Glu Ser Val 
    370                 375                 380                 


Val Thr Gly Phe Phe Pro Phe Phe Leu Ile Ala Thr Val Ile Gln Leu 
385                 390                 395                 400 


Phe Tyr Arg Gly Arg Ile Trp Asn Ile Leu Leu Phe Leu Leu Thr Val 
                405                 410                 415     


Gln Leu Val Gly Ile Ile Lys Ala Thr Tyr Ala Cys Phe Leu Arg Gly 
            420                 425                 430         


Asn Ala Glu Met Ile Phe Met Ser Leu Tyr Ser Leu Leu Tyr Met Ser 
        435                 440                 445             


Ser Leu Leu Pro Ala Lys Ile Phe Ala Ile Ala Thr Ile Asn Lys Ser 
    450                 455                 460                 


Gly Trp Gly Thr Ser Gly Arg Lys Thr Ile Val Val Asn Phe Ile Gly 
465                 470                 475                 480 


Leu Ile Pro Val Ser Ile Trp Val Ala Val Leu Leu Gly Gly Leu Ala 
                485                 490                 495     


Tyr Thr Ala Tyr Cys Gln Asp Leu Phe Ser Glu Thr Glu Leu Ala Phe 
            500                 505                 510         


Leu Val Ser Gly Ala Ile Leu Tyr Gly Cys Tyr Trp Val Ala Leu Leu 
        515                 520                 525             


Met Leu Tyr Leu Ala Ile Ile Ala Arg Arg Cys Gly Lys Lys Pro Glu 
    530                 535                 540                 


Gln Tyr Ser Leu Ala Phe Ala Glu Val 
545                 550             


<210>  774
<211>  281
<212>  PRT
<213>  Homo sapiens

<400>  774

Met Pro Val Gln Leu Thr Thr Ala Leu Arg Val Val Gly Thr Ser Leu 
1               5                   10                  15      


Phe Ala Leu Ala Val Leu Gly Gly Ile Leu Ala Ala Tyr Val Thr Gly 
            20                  25                  30          


Tyr Gln Phe Ile His Thr Glu Lys His Tyr Leu Ser Phe Gly Leu Tyr 
        35                  40                  45              


Gly Ala Ile Leu Gly Leu His Leu Leu Ile Gln Ser Leu Phe Ala Phe 
    50                  55                  60                  


Leu Glu His Arg Arg Met Arg Arg Ala Gly Gln Ala Leu Lys Leu Pro 
65                  70                  75                  80  


Ser Pro Arg Arg Gly Ser Val Ala Leu Cys Ile Ala Ala Tyr Gln Glu 
                85                  90                  95      


Asp Pro Asp Tyr Leu Arg Lys Cys Leu Arg Ser Ala Gln Arg Ile Ser 
            100                 105                 110         


Phe Pro Asp Leu Lys Val Val Met Val Val Asp Gly Asn Arg Gln Glu 
        115                 120                 125             


Asp Ala Tyr Met Leu Asp Ile Phe His Glu Val Leu Gly Gly Thr Glu 
    130                 135                 140                 


Gln Ala Gly Phe Phe Val Trp Arg Ser Asn Phe His Glu Ala Gly Glu 
145                 150                 155                 160 


Gly Glu Thr Glu Ala Ser Leu Gln Glu Gly Met Asp Arg Val Arg Asp 
                165                 170                 175     


Val Val Arg Ala Ser Thr Phe Ser Cys Ile Met Gln Lys Trp Gly Gly 
            180                 185                 190         


Lys Arg Glu Val Met Tyr Thr Ala Phe Lys Ala Leu Gly Asp Ser Val 
        195                 200                 205             


Asp Tyr Ile Gln Val Cys Asp Ser Asp Thr Val Leu Asp Pro Ala Cys 
    210                 215                 220                 


Thr Ile Glu Met Leu Arg Val Leu Glu Glu Asp Pro Gln Val Gly Gly 
225                 230                 235                 240 


Val Gly Gly Asp Val Gln Pro Pro Gly Lys Gly Met Ala Val Glu Asp 
                245                 250                 255     


Asp Gln Val Gln Ala Ala Gln Val Arg Ala Thr Glu Ala Trp Ser Val 
            260                 265                 270         


His Gln Arg His Val Ser Arg Glu Gln 
        275                 280     


<210>  775
<211>  2427
<212>  DNA
<213>  Homo sapiens

<400>  775
cctcaagtct ctttcctcac ttctttctct tcacttaaaa caattttttt ggaggggttt       60

tggggaggaa gtgagcggac gctggggatg ggtctcgtaa gcggccggat tgagaggagg      120

gaggaagcag ggggcttccg agtgggtgac ccagacgcgg gctgtggggt ggggcagttc      180

gtggggtccg gtcctggaaa ggcgtcgact gccccccaac tcttctggtt tcctctacga      240

tgagcggaag gtttgaatcc tggaggtggg gtctccggtg tggagttctg gaaactgtga      300

ggtgatttgc agctggtgga atggaacagt gaagaagcat tggaatggta gataacgcag      360

atcatctctg gaaaggatat tgatccgcct catgtaaagt atgcttagtt cctttccagt      420

ggttttgctg gaaaccatgt ctcattatac agatgaaccc agatttacca tagagcagat      480

agatctgctt cagcgacttc ggcgtactgg aatgactaaa catgaaattc tccatgcctt      540

ggaaactttg gaccgtcttg atcaagagca tagtgacaag tttggaagaa ggtccagcta      600

tggaggaagt tcatatggga atagtactaa caatgtccca gcatcttcct ctacagctac      660

agcttccaca cagacgcagc attcgggaat gtccccgtca cctagcaaca gttatgatac      720

ttccccacag ccttgcacta ccaatcaaaa tgggagggag aataatgagc gattatctac      780

atccaatgga aagatgtcac caactcgcta ccatgcaaac agcatgggtc agaggtcata      840

cagttttgaa gcctcagaag aggacctaga tgtagatgat aaagtggaag aattaatgag      900

gagggacagc agtgtgataa aagaggaaat caaagccttt cttgccaatc ggaggatttc      960

ccaagcagtt gttgcacagg taacaggtat cagtcagagc cggatctctc attggctgtt     1020

gcagcaggga tcagacctga gtgaacagaa gaaaagagca ttttaccgat ggtatcaact     1080

tgagaagaca aaccctggcg ctacactaag tatgagacca gcccccattc caatagagga     1140

ccctgaatgg agacaaacgc ctcccccagt ctctgccaca tctggtactt tccgactgcg     1200

acgagggagt cgatttacct ggagaaagga gtgcctggct gttatggaaa gttacttcaa     1260

tgagaatcaa tacccagatg aagcaaagag ggaagaaatt gcaaacgctt gcaatgcagt     1320

tatacagaag ccaggcaaaa agctgtcaga tctggaaaga gttacctccc tgaaagtata     1380

taattggttt gctaacagaa ggaaggagat caagaggaga gccaatattg aagcagcaat     1440

cctggagagt catgggatag atgtgcagag tccaggaggc cactcaaaca gtgatgatgt     1500

cgacgggaat gactactctg agcaggatga cagtacgagc catagtgacc accaagaccc     1560

catctcatta gctgtggaaa tggcagcagt caaccacact atcttggcat tggcccgaca     1620

aggagccaac gaaatcaaga cagaggccct ggatgatgac tgatcaggga ggttaaacat     1680

gacaagttaa cttagtttag acgtagcacc ttagcagact ttcctcggtc cttaacatgt     1740

gttcttacag tataacttgc agtttcttgt atgtcaggta gctgttaggg tcttgttctg     1800

tgaagatggc atggtgccct cagcctttgc atatactctc tcagtattaa ctcccagtaa     1860

ataataacca accaaccaac caaccaaact tccctctccc agcccccgag gctagaaaat     1920

cttgctgctc cgtcttagca ttccaagaaa gtgcttccag gtatttagat agccctcagt     1980

tctcaaatat tagactacgt gtaaaatctt gggtaccttt agattcttgt aacactagtc     2040

tgtactccct tttccttccc caagactgat aggatgcaag ctgaggtcgt ggcacaggaa     2100

tgacagacac catttgggga gtatccacag agtcaaagga acactagaat ccccacctca     2160

gcgtgaggat aattgatttc cagctgcaat aagccgtgcc tcattatagc cacactgtgg     2220

ctagattata cttctttggg tgctgtgcta agaatgtcaa tggaaaaagc cgatctcaga     2280

ttttgtttga agttaacatg cctgacacag acatcctttc ctctcacaag ctgtgtgact     2340

tagtagataa aatactgcct tctgcctttg ggaccatgat taaaaacaaa gacaaaaacc     2400

aaaagtcatt aaaaaaaaaa aaaaaaa                                         2427


<210>  776
<211>  420
<212>  PRT
<213>  Homo sapiens

<400>  776

Met Leu Ser Ser Phe Pro Val Val Leu Leu Glu Thr Met Ser His Tyr 
1               5                   10                  15      


Thr Asp Glu Pro Arg Phe Thr Ile Glu Gln Ile Asp Leu Leu Gln Arg 
            20                  25                  30          


Leu Arg Arg Thr Gly Met Thr Lys His Glu Ile Leu His Ala Leu Glu 
        35                  40                  45              


Thr Leu Asp Arg Leu Asp Gln Glu His Ser Asp Lys Phe Gly Arg Arg 
    50                  55                  60                  


Ser Ser Tyr Gly Gly Ser Ser Tyr Gly Asn Ser Thr Asn Asn Val Pro 
65                  70                  75                  80  


Ala Ser Ser Ser Thr Ala Thr Ala Ser Thr Gln Thr Gln His Ser Gly 
                85                  90                  95      


Met Ser Pro Ser Pro Ser Asn Ser Tyr Asp Thr Ser Pro Gln Pro Cys 
            100                 105                 110         


Thr Thr Asn Gln Asn Gly Arg Glu Asn Asn Glu Arg Leu Ser Thr Ser 
        115                 120                 125             


Asn Gly Lys Met Ser Pro Thr Arg Tyr His Ala Asn Ser Met Gly Gln 
    130                 135                 140                 


Arg Ser Tyr Ser Phe Glu Ala Ser Glu Glu Asp Leu Asp Val Asp Asp 
145                 150                 155                 160 


Lys Val Glu Glu Leu Met Arg Arg Asp Ser Ser Val Ile Lys Glu Glu 
                165                 170                 175     


Ile Lys Ala Phe Leu Ala Asn Arg Arg Ile Ser Gln Ala Val Val Ala 
            180                 185                 190         


Gln Val Thr Gly Ile Ser Gln Ser Arg Ile Ser His Trp Leu Leu Gln 
        195                 200                 205             


Gln Gly Ser Asp Leu Ser Glu Gln Lys Lys Arg Ala Phe Tyr Arg Trp 
    210                 215                 220                 


Tyr Gln Leu Glu Lys Thr Asn Pro Gly Ala Thr Leu Ser Met Arg Pro 
225                 230                 235                 240 


Ala Pro Ile Pro Ile Glu Asp Pro Glu Trp Arg Gln Thr Pro Pro Pro 
                245                 250                 255     


Val Ser Ala Thr Ser Gly Thr Phe Arg Leu Arg Arg Gly Ser Arg Phe 
            260                 265                 270         


Thr Trp Arg Lys Glu Cys Leu Ala Val Met Glu Ser Tyr Phe Asn Glu 
        275                 280                 285             


Asn Gln Tyr Pro Asp Glu Ala Lys Arg Glu Glu Ile Ala Asn Ala Cys 
    290                 295                 300                 


Asn Ala Val Ile Gln Lys Pro Gly Lys Lys Leu Ser Asp Leu Glu Arg 
305                 310                 315                 320 


Val Thr Ser Leu Lys Val Tyr Asn Trp Phe Ala Asn Arg Arg Lys Glu 
                325                 330                 335     


Ile Lys Arg Arg Ala Asn Ile Glu Ala Ala Ile Leu Glu Ser His Gly 
            340                 345                 350         


Ile Asp Val Gln Ser Pro Gly Gly His Ser Asn Ser Asp Asp Val Asp 
        355                 360                 365             


Gly Asn Asp Tyr Ser Glu Gln Asp Asp Ser Thr Ser His Ser Asp His 
    370                 375                 380                 


Gln Asp Pro Ile Ser Leu Ala Val Glu Met Ala Ala Val Asn His Thr 
385                 390                 395                 400 


Ile Leu Ala Leu Ala Arg Gln Gly Ala Asn Glu Ile Lys Thr Glu Ala 
                405                 410                 415     


Leu Asp Asp Asp 
            420 


<210>  777
<211>  420
<212>  PRT
<213>  Homo sapiens

<400>  777

Met Leu Ser Ser Phe Pro Val Val Leu Leu Glu Thr Met Ser His Tyr 
1               5                   10                  15      


Thr Asp Glu Pro Arg Phe Thr Ile Glu Gln Ile Asp Leu Leu Gln Arg 
            20                  25                  30          


Leu Arg Arg Thr Gly Met Thr Lys His Glu Ile Leu His Ala Leu Glu 
        35                  40                  45              


Thr Leu Asp Arg Leu Asp Gln Glu His Ser Asp Lys Phe Gly Arg Arg 
    50                  55                  60                  


Ser Ser Tyr Gly Gly Ser Ser Tyr Gly Asn Ser Thr Asn Asn Val Pro 
65                  70                  75                  80  


Ala Ser Ser Ser Thr Ala Thr Ala Ser Thr Gln Thr Gln His Ser Gly 
                85                  90                  95      


Met Ser Pro Ser Pro Ser Asn Ser Tyr Asp Thr Ser Pro Gln Pro Cys 
            100                 105                 110         


Thr Thr Asn Gln Asn Gly Arg Glu Asn Asn Glu Arg Leu Ser Thr Ser 
        115                 120                 125             


Asn Gly Lys Met Ser Pro Thr Arg Tyr His Ala Asn Ser Met Gly Gln 
    130                 135                 140                 


Arg Ser Tyr Ser Phe Glu Ala Ser Glu Glu Asp Leu Asp Val Asp Asp 
145                 150                 155                 160 


Lys Val Glu Glu Leu Met Arg Arg Asp Ser Ser Val Ile Lys Glu Glu 
                165                 170                 175     


Ile Lys Ala Phe Leu Ala Asn Arg Arg Ile Ser Gln Ala Val Val Ala 
            180                 185                 190         


Gln Val Thr Gly Ile Ser Gln Ser Arg Ile Ser His Trp Leu Leu Gln 
        195                 200                 205             


Gln Gly Ser Asp Leu Ser Glu Gln Lys Lys Arg Ala Phe Tyr Arg Trp 
    210                 215                 220                 


Tyr Gln Leu Glu Lys Thr Asn Pro Gly Ala Thr Leu Ser Met Arg Pro 
225                 230                 235                 240 


Ala Pro Ile Pro Ile Glu Asp Pro Glu Trp Arg Gln Thr Pro Pro Pro 
                245                 250                 255     


Val Ser Ala Thr Ser Gly Thr Phe Arg Leu Arg Arg Gly Ser Arg Phe 
            260                 265                 270         


Thr Trp Arg Lys Glu Cys Leu Ala Val Met Glu Ser Tyr Phe Asn Glu 
        275                 280                 285             


Asn Gln Tyr Pro Asp Glu Ala Lys Arg Glu Glu Ile Ala Asn Ala Cys 
    290                 295                 300                 


Asn Ala Val Ile Gln Lys Pro Gly Lys Lys Leu Ser Asp Leu Glu Arg 
305                 310                 315                 320 


Val Thr Ser Leu Lys Val Tyr Asn Trp Phe Ala Asn Arg Arg Lys Glu 
                325                 330                 335     


Ile Lys Arg Arg Ala Asn Ile Glu Ala Ala Ile Leu Glu Ser His Gly 
            340                 345                 350         


Ile Asp Val Gln Ser Pro Gly Gly His Ser Asn Ser Asp Asp Val Asp 
        355                 360                 365             


Gly Asn Asp Tyr Ser Glu Gln Asp Asp Ser Thr Ser His Ser Asp His 
    370                 375                 380                 


Gln Asp Pro Ile Ser Leu Ala Val Glu Met Ala Ala Val Asn His Thr 
385                 390                 395                 400 


Ile Leu Ala Leu Ala Arg Gln Gly Ala Asn Glu Ile Lys Thr Glu Ala 
                405                 410                 415     


Leu Asp Asp Asp 
            420 


<210>  778
<211>  3221
<212>  DNA
<213>  Homo sapiens

<400>  778
caccgccaca aggaggcagg gaagaaaccc actagtccca gctcctgggg tggcacagac       60

attgcaactg gccctgcctg tgggtcctag gggcccttgg ctaccaggag gctaagaaca      120

ctgctcatga atgacagtga gccctgaaag ctctgggggt gtcacccagt cccacaagcc      180

tgcatcccct gcagtggaga tgggctcagc tcctggacgt gccacagaca gaaagcataa      240

catacactcg ccaggaagag cctttgcctg actcagggca gctcagagtg tggggcagaa      300

ggtgaccagc cagctcaggg caggagatgc agagcacagc caattacctg tggcacacag      360

atgacctgct ggggcagggg gccactgcca gtgtgtacaa ggcccgcaac aagaaatccg      420

gagagctggt tgctgtgaag gtcttcaaca ctaccagcta cctgcggccc cgcgaggtgc      480

aggtgaggga gtttgaggtc ctgcggaagc tgaaccacca gaacatcgtc aagctctttg      540

cggtggagga gacgggcgga agccggcaga aggtactggt gatggagtac tgctccagtg      600

ggagcctgct gagtgtgctg gagagccctg agaatgcctt tgggctgcct gaggatgagt      660

tcctggtggt gctgcgctgt gtggtggccg gcatgaacca cctgcgggag aacggcattg      720

tgcatcgcga catcaagccg gggaacatca tgcgcctcgt aggggaggag gggcagagca      780

tctacaagct gacagacttc ggcgctgccc gggagctgga tgatgatgag aagttcgtct      840

cggtctatgg gactgaggag tacctgcatc ccgacatgta tgagcgggcg gtgcttcgaa      900

agccccagca aaaagcgttc ggggtgactg tggatctctg gagcattgga gtgaccttgt      960

accatgcagc cactggcagc ctgcccttca tcccctttgg tgggccacgg cggaacaagg     1020

agatcatgta ccggatcacc acggagaagc cggctggggc cattgcaggt gcccagaggc     1080

gggagaacgg gcccctggag tggagctaca ccctccccat cacctgccag ctgtcactgg     1140

ggctgcagag ccagctggtg cccatcctgg ccaacatcct ggaggtggag caggccaagt     1200

gctggggctt cgaccagttc tttgcggaga ccagtgacat cctgcagcga gttgtcgtcc     1260

atgtcttctc cctgtcccag gcagtcctgc accacatcta tatccatgcc cacaacacga     1320

tagccatttt ccaggaggcc gtgcacaagc agaccagtgt ggccccccga caccaggagt     1380

acctctttga gggtcacctc tgtgtcctcg agcccagcgt ctcagcacag cacatcgccc     1440

acacgacggc aagcagcccc ctgaccctct tcagcacagc catccctaag gggctggcct     1500

tcagggaccc tgctctggac gtccccaagt tcgtccccaa agtggacctg caggcggatt     1560

acaacactgc caagggcgtg ttgggcgccg gctaccaggc cctgcggctg gcacgggccc     1620

tgctggatgg gcaggagcta atgtttcggg ggctgcactg ggtcatggag gtgctccagg     1680

ccacatgcag acggactctg gaagtggcaa ggacatccct cctctacctc agcagcagcc     1740

tgggaactga gaggttcagc agcgtggctg gaacgcctga gatccaggaa ctgaaggcgg     1800

ctgcagaact gaggtccagg ctgcggactc tagcggaggt cctctccaga tgctcccaaa     1860

atatcacgga gacccaggag agcctgagca gcctgaaccg ggagctggtg aagagccggg     1920

atcaggtaca tgaggacaga agcatccagc agattcagtg ctgtttggac aagatgaact     1980

tcatctacaa acagttcaag aagtctagga tgaggccagg gcttggctac aacgaggagc     2040

agattcacaa gctggataag gtgaatttca gtcatttagc caaaagactc ctgcaggtgt     2100

tccaggagga gtgcgtgcag aagtatcaag cgtccttagt cacacacggc aagaggatga     2160

gggtggtgca cgagaccagg aaccacctgc gcctggttgg ctgttctgtg gctgcctgta     2220

acacagaagc ccagggggtc caggagagtc tcagcaagct cctggaagag ctatctcacc     2280

agctccttca ggaccgagca aagggggctc aggcctcgcc gcctcccata gctccttacc     2340

ccagccctac acgaaaggac ctgcttctcc acatgcaaga gctctgcgag gggatgaagc     2400

tgctggcatc tgacctcctg gacaacaacc gcatcatcga acggctaaat agagtcccag     2460

cacctcctga tgtctgagct ccatggggca catgaggcat cctgaagcat tagaatgatt     2520

ccaacactgc tcttctgcac catgagacca acccagggca agatcccatc ccatcacatc     2580

agcctacctc cctcctggct gctggccagg atgtcgccag cattaccttc cactgccttt     2640

ctccctggga agcagcacag ctgagactgg gcaccaggcc acctctgttg ggacccacag     2700

gaaagagtgt ggcagcaact gcctggctga cctttctatc ttctctaggc tcaggtactg     2760

ctcctccatg cccatggctg ggccgtgggg agaagaagct ctcatacgcc ttcccactcc     2820

ctctggttta taggacttca ctccctagcc aacaggagag gaggcctcct ggggtttccc     2880

cagggcagta ggtcaaacga cctcatcaca gtcttccttc ctcttcaagc gtttcatgtt     2940

gaacacagct ctctccactc ccttgtgatt tctgagggtc accactgcca gcctcaggca     3000

acatagagag cctcctgttc tttctatgct tggtctgact gagcctaaag ttgagaaaat     3060

gggtggccaa ggccagtgcc agtgtcttgg ggcccctttg gctctccctc actctctgag     3120

gctccagctg gtcctgggac atgcagccag gactgtgagt ctgggcacgt ccaaggcctg     3180

caccttcaag aagtggaata aatgtggcct ttgcttctgt t                         3221


<210>  779
<211>  716
<212>  PRT
<213>  Homo sapiens

<400>  779

Met Gln Ser Thr Ala Asn Tyr Leu Trp His Thr Asp Asp Leu Leu Gly 
1               5                   10                  15      


Gln Gly Ala Thr Ala Ser Val Tyr Lys Ala Arg Asn Lys Lys Ser Gly 
            20                  25                  30          


Glu Leu Val Ala Val Lys Val Phe Asn Thr Thr Ser Tyr Leu Arg Pro 
        35                  40                  45              


Arg Glu Val Gln Val Arg Glu Phe Glu Val Leu Arg Lys Leu Asn His 
    50                  55                  60                  


Gln Asn Ile Val Lys Leu Phe Ala Val Glu Glu Thr Gly Gly Ser Arg 
65                  70                  75                  80  


Gln Lys Val Leu Val Met Glu Tyr Cys Ser Ser Gly Ser Leu Leu Ser 
                85                  90                  95      


Val Leu Glu Ser Pro Glu Asn Ala Phe Gly Leu Pro Glu Asp Glu Phe 
            100                 105                 110         


Leu Val Val Leu Arg Cys Val Val Ala Gly Met Asn His Leu Arg Glu 
        115                 120                 125             


Asn Gly Ile Val His Arg Asp Ile Lys Pro Gly Asn Ile Met Arg Leu 
    130                 135                 140                 


Val Gly Glu Glu Gly Gln Ser Ile Tyr Lys Leu Thr Asp Phe Gly Ala 
145                 150                 155                 160 


Ala Arg Glu Leu Asp Asp Asp Glu Lys Phe Val Ser Val Tyr Gly Thr 
                165                 170                 175     


Glu Glu Tyr Leu His Pro Asp Met Tyr Glu Arg Ala Val Leu Arg Lys 
            180                 185                 190         


Pro Gln Gln Lys Ala Phe Gly Val Thr Val Asp Leu Trp Ser Ile Gly 
        195                 200                 205             


Val Thr Leu Tyr His Ala Ala Thr Gly Ser Leu Pro Phe Ile Pro Phe 
    210                 215                 220                 


Gly Gly Pro Arg Arg Asn Lys Glu Ile Met Tyr Arg Ile Thr Thr Glu 
225                 230                 235                 240 


Lys Pro Ala Gly Ala Ile Ala Gly Ala Gln Arg Arg Glu Asn Gly Pro 
                245                 250                 255     


Leu Glu Trp Ser Tyr Thr Leu Pro Ile Thr Cys Gln Leu Ser Leu Gly 
            260                 265                 270         


Leu Gln Ser Gln Leu Val Pro Ile Leu Ala Asn Ile Leu Glu Val Glu 
        275                 280                 285             


Gln Ala Lys Cys Trp Gly Phe Asp Gln Phe Phe Ala Glu Thr Ser Asp 
    290                 295                 300                 


Ile Leu Gln Arg Val Val Val His Val Phe Ser Leu Ser Gln Ala Val 
305                 310                 315                 320 


Leu His His Ile Tyr Ile His Ala His Asn Thr Ile Ala Ile Phe Gln 
                325                 330                 335     


Glu Ala Val His Lys Gln Thr Ser Val Ala Pro Arg His Gln Glu Tyr 
            340                 345                 350         


Leu Phe Glu Gly His Leu Cys Val Leu Glu Pro Ser Val Ser Ala Gln 
        355                 360                 365             


His Ile Ala His Thr Thr Ala Ser Ser Pro Leu Thr Leu Phe Ser Thr 
    370                 375                 380                 


Ala Ile Pro Lys Gly Leu Ala Phe Arg Asp Pro Ala Leu Asp Val Pro 
385                 390                 395                 400 


Lys Phe Val Pro Lys Val Asp Leu Gln Ala Asp Tyr Asn Thr Ala Lys 
                405                 410                 415     


Gly Val Leu Gly Ala Gly Tyr Gln Ala Leu Arg Leu Ala Arg Ala Leu 
            420                 425                 430         


Leu Asp Gly Gln Glu Leu Met Phe Arg Gly Leu His Trp Val Met Glu 
        435                 440                 445             


Val Leu Gln Ala Thr Cys Arg Arg Thr Leu Glu Val Ala Arg Thr Ser 
    450                 455                 460                 


Leu Leu Tyr Leu Ser Ser Ser Leu Gly Thr Glu Arg Phe Ser Ser Val 
465                 470                 475                 480 


Ala Gly Thr Pro Glu Ile Gln Glu Leu Lys Ala Ala Ala Glu Leu Arg 
                485                 490                 495     


Ser Arg Leu Arg Thr Leu Ala Glu Val Leu Ser Arg Cys Ser Gln Asn 
            500                 505                 510         


Ile Thr Glu Thr Gln Glu Ser Leu Ser Ser Leu Asn Arg Glu Leu Val 
        515                 520                 525             


Lys Ser Arg Asp Gln Val His Glu Asp Arg Ser Ile Gln Gln Ile Gln 
    530                 535                 540                 


Cys Cys Leu Asp Lys Met Asn Phe Ile Tyr Lys Gln Phe Lys Lys Ser 
545                 550                 555                 560 


Arg Met Arg Pro Gly Leu Gly Tyr Asn Glu Glu Gln Ile His Lys Leu 
                565                 570                 575     


Asp Lys Val Asn Phe Ser His Leu Ala Lys Arg Leu Leu Gln Val Phe 
            580                 585                 590         


Gln Glu Glu Cys Val Gln Lys Tyr Gln Ala Ser Leu Val Thr His Gly 
        595                 600                 605             


Lys Arg Met Arg Val Val His Glu Thr Arg Asn His Leu Arg Leu Val 
    610                 615                 620                 


Gly Cys Ser Val Ala Ala Cys Asn Thr Glu Ala Gln Gly Val Gln Glu 
625                 630                 635                 640 


Ser Leu Ser Lys Leu Leu Glu Glu Leu Ser His Gln Leu Leu Gln Asp 
                645                 650                 655     


Arg Ala Lys Gly Ala Gln Ala Ser Pro Pro Pro Ile Ala Pro Tyr Pro 
            660                 665                 670         


Ser Pro Thr Arg Lys Asp Leu Leu Leu His Met Gln Glu Leu Cys Glu 
        675                 680                 685             


Gly Met Lys Leu Leu Ala Ser Asp Leu Leu Asp Asn Asn Arg Ile Ile 
    690                 695                 700                 


Glu Arg Leu Asn Arg Val Pro Ala Pro Pro Asp Val 
705                 710                 715     


<210>  780
<211>  716
<212>  PRT
<213>  Homo sapiens

<400>  780

Met Gln Ser Thr Ala Asn Tyr Leu Trp His Thr Asp Asp Leu Leu Gly 
1               5                   10                  15      


Gln Gly Ala Thr Ala Ser Val Tyr Lys Ala Arg Asn Lys Lys Ser Gly 
            20                  25                  30          


Glu Leu Val Ala Val Lys Val Phe Asn Thr Thr Ser Tyr Leu Arg Pro 
        35                  40                  45              


Arg Glu Val Gln Val Arg Glu Phe Glu Val Leu Arg Lys Leu Asn His 
    50                  55                  60                  


Gln Asn Ile Val Lys Leu Phe Ala Val Glu Glu Thr Gly Gly Ser Arg 
65                  70                  75                  80  


Gln Lys Val Leu Val Met Glu Tyr Cys Ser Ser Gly Ser Leu Leu Ser 
                85                  90                  95      


Val Leu Glu Ser Pro Glu Asn Ala Phe Gly Leu Pro Glu Asp Glu Phe 
            100                 105                 110         


Leu Val Val Leu Arg Cys Val Val Ala Gly Met Asn His Leu Arg Glu 
        115                 120                 125             


Asn Gly Ile Val His Arg Asp Ile Lys Pro Gly Asn Ile Met Arg Leu 
    130                 135                 140                 


Val Gly Glu Glu Gly Gln Ser Ile Tyr Lys Leu Thr Asp Phe Gly Ala 
145                 150                 155                 160 


Ala Arg Glu Leu Asp Asp Asp Glu Lys Phe Val Ser Val Tyr Gly Thr 
                165                 170                 175     


Glu Glu Tyr Leu His Pro Asp Met Tyr Glu Arg Ala Val Leu Arg Lys 
            180                 185                 190         


Pro Gln Gln Lys Ala Phe Gly Val Thr Val Asp Leu Trp Ser Ile Gly 
        195                 200                 205             


Val Thr Leu Tyr His Ala Ala Thr Gly Ser Leu Pro Phe Ile Pro Phe 
    210                 215                 220                 


Gly Gly Pro Arg Arg Asn Lys Glu Ile Met Tyr Arg Ile Thr Thr Glu 
225                 230                 235                 240 


Lys Pro Ala Gly Ala Ile Ala Gly Ala Gln Arg Arg Glu Asn Gly Pro 
                245                 250                 255     


Leu Glu Trp Ser Tyr Thr Leu Pro Ile Thr Cys Gln Leu Ser Leu Gly 
            260                 265                 270         


Leu Gln Ser Gln Leu Val Pro Ile Leu Ala Asn Ile Leu Glu Val Glu 
        275                 280                 285             


Gln Ala Lys Cys Trp Gly Phe Asp Gln Phe Phe Ala Glu Thr Ser Asp 
    290                 295                 300                 


Ile Leu Gln Arg Val Val Val His Val Phe Ser Leu Ser Gln Ala Val 
305                 310                 315                 320 


Leu His His Ile Tyr Ile His Ala His Asn Thr Ile Ala Ile Phe Gln 
                325                 330                 335     


Glu Ala Val His Lys Gln Thr Ser Val Ala Pro Arg His Gln Glu Tyr 
            340                 345                 350         


Leu Phe Glu Gly His Leu Cys Val Leu Glu Pro Ser Val Ser Ala Gln 
        355                 360                 365             


His Ile Ala His Thr Thr Ala Ser Ser Pro Leu Thr Leu Phe Ser Thr 
    370                 375                 380                 


Ala Ile Pro Lys Gly Leu Ala Phe Arg Asp Pro Ala Leu Asp Val Pro 
385                 390                 395                 400 


Lys Phe Val Pro Lys Val Asp Leu Gln Ala Asp Tyr Asn Thr Ala Lys 
                405                 410                 415     


Gly Val Leu Gly Ala Gly Tyr Gln Ala Leu Arg Leu Ala Arg Ala Leu 
            420                 425                 430         


Leu Asp Gly Gln Glu Leu Met Phe Arg Gly Leu His Trp Val Met Glu 
        435                 440                 445             


Val Leu Gln Ala Thr Cys Arg Arg Thr Leu Glu Val Ala Arg Thr Ser 
    450                 455                 460                 


Leu Leu Tyr Leu Ser Ser Ser Leu Gly Thr Glu Arg Phe Ser Ser Val 
465                 470                 475                 480 


Ala Gly Thr Pro Glu Ile Gln Glu Leu Lys Ala Ala Ala Glu Leu Arg 
                485                 490                 495     


Ser Arg Leu Arg Thr Leu Ala Glu Val Leu Ser Arg Cys Ser Gln Asn 
            500                 505                 510         


Ile Thr Glu Thr Gln Glu Ser Leu Ser Ser Leu Asn Arg Glu Leu Val 
        515                 520                 525             


Lys Ser Arg Asp Gln Val His Glu Asp Arg Ser Ile Gln Gln Ile Gln 
    530                 535                 540                 


Cys Cys Leu Asp Lys Met Asn Phe Ile Tyr Lys Gln Phe Lys Lys Ser 
545                 550                 555                 560 


Arg Met Arg Pro Gly Leu Gly Tyr Asn Glu Glu Gln Ile His Lys Leu 
                565                 570                 575     


Asp Lys Val Asn Phe Ser His Leu Ala Lys Arg Leu Leu Gln Val Phe 
            580                 585                 590         


Gln Glu Glu Cys Val Gln Lys Tyr Gln Ala Ser Leu Val Thr His Gly 
        595                 600                 605             


Lys Arg Met Arg Val Val His Glu Thr Arg Asn His Leu Arg Leu Val 
    610                 615                 620                 


Gly Cys Ser Val Ala Ala Cys Asn Thr Glu Ala Gln Gly Val Gln Glu 
625                 630                 635                 640 


Ser Leu Ser Lys Leu Leu Glu Glu Leu Ser His Gln Leu Leu Gln Asp 
                645                 650                 655     


Arg Ala Lys Gly Ala Gln Ala Ser Pro Pro Pro Ile Ala Pro Tyr Pro 
            660                 665                 670         


Ser Pro Thr Arg Lys Asp Leu Leu Leu His Met Gln Glu Leu Cys Glu 
        675                 680                 685             


Gly Met Lys Leu Leu Ala Ser Asp Leu Leu Asp Asn Asn Arg Ile Ile 
    690                 695                 700                 


Glu Arg Leu Asn Arg Val Pro Ala Pro Pro Asp Val 
705                 710                 715     


<210>  781
<211>  957
<212>  DNA
<213>  Homo sapiens

<400>  781
gtggagtaaa atggctgccg cctgggggtc gtccctaacg gccgcgacgc agagagcggt       60

cactccctgg ccgaggggca ggctcctcac ggcctccctg ggaccccagg cgcgtcggga      120

ggcgtcgtcc tccagccccg aggccggcga agggcagatc tgcctcacag acagttgcgt      180

ccagaggctt ttggaaatca ccgaagggtc agaattcctc aggctgcaag tggagggagg      240

tggatgctcc ggattccaat acaaattttc actggataca gttatcaacc ccgacgacag      300

ggtatttgaa cagggtgggg caagagtggt ggttgactct gatagcttgg ccttcgtgaa      360

aggggcccag gtggacttca gccaagaact gatccgaagc tcatttcaag tgttgaacaa      420

tcctcaagca cagcaaggct gctcctgtgg gtcatctttc tctatcaaac tttgatgtga      480

tgactggtga ctctgggatt gtcaccagtt gtaccaattt gaagaacgtg gaattagtag      540

aattctagaa gtttacttct aatcatgtcc ctctcaattt tatttcccgc agtccaggag      600

tgttatgttt tgccactatt attttcagaa tgtgaagatt ttactcttgg cttaattttt      660

ccctccactc agtgctaagg ctgagcctcc agatgctgtt acctcagatt taatcactgg      720

ttgaaactcc gtataatctg tagagcctcc atggctctaa aatttggaat taacttctct      780

tgccttaaga gctgcttgta catatgtgga tagctatgta taaaagcttc attttaaaga      840

aggttcttat tgtgttgtgg atcagggtca cagattgggt agcttggaca ccagttatta      900

gaggatgaga aaagtaaatg aaatgttctc tttttcactt caaaaaaaaa aaaaaaa         957


<210>  782
<211>  154
<212>  PRT
<213>  Homo sapiens

<400>  782

Met Ala Ala Ala Trp Gly Ser Ser Leu Thr Ala Ala Thr Gln Arg Ala 
1               5                   10                  15      


Val Thr Pro Trp Pro Arg Gly Arg Leu Leu Thr Ala Ser Leu Gly Pro 
            20                  25                  30          


Gln Ala Arg Arg Glu Ala Ser Ser Ser Ser Pro Glu Ala Gly Glu Gly 
        35                  40                  45              


Gln Ile Arg Leu Thr Asp Ser Cys Val Gln Arg Leu Leu Glu Ile Thr 
    50                  55                  60                  


Glu Gly Ser Glu Phe Leu Arg Leu Gln Val Glu Gly Gly Gly Cys Ser 
65                  70                  75                  80  


Gly Phe Gln Tyr Lys Phe Ser Leu Asp Thr Val Ile Asn Pro Asp Asp 
                85                  90                  95      


Arg Val Phe Glu Gln Gly Gly Ala Arg Val Val Val Asp Ser Asp Ser 
            100                 105                 110         


Leu Ala Phe Val Lys Gly Ala Gln Val Asp Phe Ser Gln Glu Leu Ile 
        115                 120                 125             


Arg Ser Ser Phe Gln Val Leu Asn Asn Pro Gln Ala Gln Gln Gly Cys 
    130                 135                 140                 


Ser Cys Gly Ser Ser Phe Ser Ile Lys Leu 
145                 150                 


<210>  783
<211>  154
<212>  PRT
<213>  Homo sapiens

<400>  783

Met Ala Ala Ala Trp Gly Ser Ser Leu Thr Ala Ala Thr Gln Arg Ala 
1               5                   10                  15      


Val Thr Pro Trp Pro Arg Gly Arg Leu Leu Thr Ala Ser Leu Gly Pro 
            20                  25                  30          


Gln Ala Arg Arg Glu Ala Ser Ser Ser Ser Pro Glu Ala Gly Glu Gly 
        35                  40                  45              


Gln Ile Cys Leu Thr Asp Ser Cys Val Gln Arg Leu Leu Glu Ile Thr 
    50                  55                  60                  


Glu Gly Ser Glu Phe Leu Arg Leu Gln Val Glu Gly Gly Gly Cys Ser 
65                  70                  75                  80  


Gly Phe Gln Tyr Lys Phe Ser Leu Asp Thr Val Ile Asn Pro Asp Asp 
                85                  90                  95      


Arg Val Phe Glu Gln Gly Gly Ala Arg Val Val Val Asp Ser Asp Ser 
            100                 105                 110         


Leu Ala Phe Val Lys Gly Ala Gln Val Asp Phe Ser Gln Glu Leu Ile 
        115                 120                 125             


Arg Ser Ser Phe Gln Val Leu Asn Asn Pro Gln Ala Gln Gln Gly Cys 
    130                 135                 140                 


Ser Cys Gly Ser Ser Phe Ser Ile Lys Leu 
145                 150                 


<210>  784
<211>  1206
<212>  DNA
<213>  Homo sapiens

<400>  784
tacgcgcctt ggggtccggg tcggctttcc ccgggacccc tggccggaaa ctgagccgtt       60

cacttccgcc accagccgga agttttctgt cactggacgc caaggagttt tcggtggctc      120

agctgggtaa ccggggatca ccatggcggc ctcattggtg gggaagaaga tcgtgtttgt      180

aacggggaac gccaagaagc tggaggaggt cgttcagatt ctaggagata agtttccatg      240

cactttggtg gcacagaaaa ttgacctgcc ggagtaccag ggggagccgg atgagatttc      300

catacagaaa tgtcaggagg cagttcgcca ggtacagggg cccgtgctgg ttgaggacac      360

ttgtctgtgc ttcaatgccc ttggagggct ccccggcccc tacataaagt ggtttctgga      420

gaagttaaag cctgaaggtc tccaccagct cctggccggg ttcgaggaca agtcagccta      480

tgcgctctgc acgtttgcac tcagcaccgg ggacccaagc cagcccgtgc gcctgttcag      540

gggccggacc tcgggccgga tcgtggcacc cagaggctgc caggactttg gctgggaccc      600

ctgctttcag cctgatggat atgagcagac gtacgcagag atgcctaagg cggagaagaa      660

cgctgtctcc catcgcttcc gggccctgct ggagctgcag gagtactttg gcagtttggc      720

agcttgactt ctgcagctgg aggaggcccc tcaggccggg gatctgggga gggctagccc      780

aaaacctccc gcatcgggca ggcaccccct gaagtacttc cttcagggtt tcccctttgt      840

gagggtgtcg agtagcctca ccggcctgtc tggaggagca gctggctctg ctctgagaaa      900

ctctggcaag tggacgccat tctcttgccc ttaggattca ctgctctctc ctacagccgc      960

caggcctggg gtcctgaaag gaccttgggt ggtaaagctg tacttggtgg gagtgagggc     1020

gtggggagga accatgcaaa tcgccttcca tggtttttaa atgcagtaaa taacatttct     1080

ggatgagact tgtttccaaa ataaaccagc tatatctgtt ttgaaaaaaa aaaaaaaaaa     1140

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa     1200

aaaaaa                                                                1206


<210>  785
<211>  194
<212>  PRT
<213>  Homo sapiens

<400>  785

Met Ala Ala Ser Leu Val Gly Lys Lys Ile Val Phe Val Thr Gly Asn 
1               5                   10                  15      


Ala Lys Lys Leu Glu Glu Val Val Gln Ile Leu Gly Asp Lys Phe Pro 
            20                  25                  30          


Cys Thr Leu Val Ala Gln Lys Ile Asp Leu Pro Glu Tyr Gln Gly Glu 
        35                  40                  45              


Pro Asp Glu Ile Ser Ile Gln Lys Cys Gln Glu Ala Val Arg Gln Val 
    50                  55                  60                  


Gln Gly Pro Val Leu Val Glu Asp Thr Cys Leu Cys Phe Asn Ala Leu 
65                  70                  75                  80  


Gly Gly Leu Pro Gly Pro Tyr Ile Lys Trp Phe Leu Glu Lys Leu Lys 
                85                  90                  95      


Pro Glu Gly Leu His Gln Leu Leu Ala Gly Phe Glu Asp Lys Ser Ala 
            100                 105                 110         


Tyr Ala Leu Cys Thr Phe Ala Leu Ser Thr Gly Asp Pro Ser Gln Pro 
        115                 120                 125             


Val Arg Leu Phe Arg Gly Arg Thr Ser Gly Arg Ile Val Ala Pro Arg 
    130                 135                 140                 


Gly Cys Gln Asp Phe Gly Trp Asp Pro Cys Phe Gln Pro Asp Gly Tyr 
145                 150                 155                 160 


Glu Gln Thr Tyr Ala Glu Met Pro Lys Ala Glu Lys Asn Ala Val Ser 
                165                 170                 175     


His Arg Phe Arg Ala Leu Leu Glu Leu Gln Glu Tyr Phe Gly Ser Leu 
            180                 185                 190         


Ala Ala 
        


<210>  786
<211>  194
<212>  PRT
<213>  Homo sapiens

<400>  786

Met Ala Ala Ser Leu Val Gly Lys Lys Ile Val Phe Val Thr Gly Asn 
1               5                   10                  15      


Ala Lys Lys Leu Glu Glu Val Val Gln Ile Leu Gly Asp Lys Phe Pro 
            20                  25                  30          


Cys Thr Leu Val Ala Gln Lys Ile Asp Leu Pro Glu Tyr Gln Gly Glu 
        35                  40                  45              


Pro Asp Glu Ile Ser Ile Gln Lys Cys Gln Glu Ala Val Arg Gln Val 
    50                  55                  60                  


Gln Gly Pro Val Leu Val Glu Asp Thr Cys Leu Cys Phe Asn Ala Leu 
65                  70                  75                  80  


Gly Gly Leu Pro Gly Pro Tyr Ile Lys Trp Phe Leu Glu Lys Leu Lys 
                85                  90                  95      


Pro Glu Gly Leu His Gln Leu Leu Ala Gly Phe Glu Asp Lys Ser Ala 
            100                 105                 110         


Tyr Ala Leu Cys Thr Phe Ala Leu Ser Thr Gly Asp Pro Ser Gln Pro 
        115                 120                 125             


Val Arg Leu Phe Arg Gly Arg Thr Ser Gly Arg Ile Val Ala Pro Arg 
    130                 135                 140                 


Gly Cys Gln Asp Phe Gly Trp Asp Pro Cys Phe Gln Pro Asp Gly Tyr 
145                 150                 155                 160 


Glu Gln Thr Tyr Ala Glu Met Pro Lys Ala Glu Lys Asn Ala Val Ser 
                165                 170                 175     


His Arg Phe Arg Ala Leu Leu Glu Leu Gln Glu Tyr Phe Gly Ser Leu 
            180                 185                 190         


Ala Ala 
        


<210>  787
<211>  2090
<212>  DNA
<213>  Homo sapiens

<400>  787
ctcgccgcca aaccatgaac cgatgccccc gcaggtgccg gagcccgctg gggcaggcag       60

cgcgatccct ctaccagctg gtgactgggt cgctgtcccc agacagcgtg gacgatgaat      120

ttgaattgtc caccgtgtgt caccggcctg agggtctgga gcagctgcag gagcaaacca      180

aattcacgcg caaggagttg caggtcctgt accggggctt caagaacgaa tgtcccagcg      240

gaattgtcaa tgaggagaac ttcaagcaga tttactccca gttctttcct caaggagact      300

ccagcaccta tgccactttt ctcttcaatg cctttgacac caaccatgat ggctcggtca      360

gttttgagga ctttgtggct ggtttgtccg tgattcttcg gggaactgta gatgacaggc      420

ttaattgggc cttcaacctg tatgacctta acaaggacgg ctgcatcacc aaggaggaaa      480

tgcttgacat catgaagtcc atctatgaca tgatgggcaa gtacacgtac cctgcactcc      540

gggaggaggc cccaagggaa cacgtggaga gcttcttcca gaagatggac agaaacaagg      600

atggtgtggt gaccattgag gaattcattg agtcttgtca aaaggatgag aacatcatga      660

ggtccatgca gctctttgac aatgtcatct agcccccagg agagggggtc agtgtttcct      720

ggggggacca tgctctaacc ctagtccagg cggacctcac ccttctcttc ccaggtctat      780

cctcatccta cgcctccctg ggggctggag ggatccaaga gcttggggat tcagtagtcc      840

agatctctgg agctgaaggg gccagagagt gggcagagtg catctcgggg ggtgttccca      900

actcccacca gctctcaccc ccttcctgcc tgacacccag tgttgagagt gcccctcctg      960

taggaattga gcggttcccc acctcctacc cctactctag aaacacacta gacagatgtc     1020

tcctgctatg gtgcttcccc catccctgac ctcataaaca tttcccctaa gactcccctc     1080

tcagagagaa tgctccattc ttggcactgg ctggcttctc agaccagcca ttgagagccc     1140

tgtgggaggg ggacaagaat gtatagggag aaatcttggg cctgagtcaa tggataggtc     1200

ctaggaggtg gctggggttg agaatagaag ggcctggaca gattatgatt gctcaggcat     1260

accaggttat agctccaagt tccacaggtc tgctaccaca ggccatcaaa atataagttt     1320

ccaggctttg cagaagacct tgtctcctta gaaatgcccc agaaattttc cacaccctcc     1380

tcggtatcca tggagagcct ggggccagat atctggctca tctctggcat tgcttcctct     1440

ccttccttcc tgcatgtgtt ggtggtggtt gtggtggggg aatgtggatg ggggatgtcc     1500

tggctgatgc ctgccaaaat ttcatcccac cctccttgct tatcgtccct gttttgaggg     1560

ctatgacttg agtttttgtt tcccatgttc tctatagact tgggaccttc ctgaacttgg     1620

ggcctatcac tccccacagt ggatgcctta gaagggagag ggaaggaggg aggcaggcat     1680

agcatctgaa cccagtgtgg gggcattcac tagaatcttc aatcaacctg ggctctcccc     1740

accccacccc agataacctc ctcagttccc tagggtctct tcttgcttga ctcaatctac     1800

ccagagatgc cccttagcac acctagaggg cagggaccat aggacccagg ttccaacccc     1860

attgtcagca ccccagccat gcggccaccc cttagcacac ctgctcgtcc catttagctt     1920

accctcccag ttggccagaa tctgagggga gagcccccag agagccccct tccccatcag     1980

aagactgttg actgctttgc attttgggct cttctatata ttttgtaaag taagaaatat     2040

accagatcta ataaaacaca atggctatgc aaaaaaaaaa aaaaaaaaaa                2090


<210>  788
<211>  270
<212>  PRT
<213>  Homo sapiens

<400>  788

Met Arg Gly Gln Gly Arg Lys Glu Ser Leu Ser Asp Ser Arg Asp Leu 
1               5                   10                  15      


Asp Gly Ser Tyr Asp Gln Leu Thr Gly His Pro Pro Gly Pro Thr Lys 
            20                  25                  30          


Lys Ala Leu Lys Gln Arg Phe Leu Lys Leu Leu Pro Cys Cys Gly Pro 
        35                  40                  45              


Gln Val Leu Pro Ser Val Ser Glu Thr Leu Ala Ala Pro Ala Ser Leu 
    50                  55                  60                  


Arg Pro His Arg Pro Arg Pro Leu Asp Pro Asp Ser Val Asp Asp Glu 
65                  70                  75                  80  


Phe Glu Leu Ser Thr Val Cys His Arg Pro Glu Gly Leu Glu Gln Leu 
                85                  90                  95      


Gln Glu Gln Thr Lys Phe Thr Arg Lys Glu Leu Gln Val Leu Tyr Arg 
            100                 105                 110         


Gly Phe Lys Asn Glu Cys Pro Ser Gly Ile Val Asn Glu Glu Asn Phe 
        115                 120                 125             


Lys Gln Ile Tyr Ser Gln Phe Phe Pro Gln Gly Asp Ser Ser Thr Tyr 
    130                 135                 140                 


Ala Thr Phe Leu Phe Asn Ala Phe Asp Thr Asn His Asp Gly Ser Val 
145                 150                 155                 160 


Ser Phe Glu Asp Phe Val Ala Gly Leu Ser Val Ile Leu Arg Gly Thr 
                165                 170                 175     


Val Asp Asp Arg Leu Asn Trp Ala Phe Asn Leu Tyr Asp Leu Asn Lys 
            180                 185                 190         


Asp Gly Cys Ile Thr Lys Glu Glu Met Leu Asp Ile Met Lys Ser Ile 
        195                 200                 205             


Tyr Asp Met Met Gly Lys Tyr Thr Tyr Pro Ala Leu Arg Glu Glu Ala 
    210                 215                 220                 


Pro Arg Glu His Val Glu Ser Phe Phe Gln Lys Met Asp Arg Asn Lys 
225                 230                 235                 240 


Asp Gly Val Val Thr Ile Glu Glu Phe Ile Glu Ser Cys Gln Lys Asp 
                245                 250                 255     


Glu Asn Ile Met Arg Ser Met Gln Leu Phe Asp Asn Val Ile 
            260                 265                 270 


<210>  789
<211>  225
<212>  PRT
<213>  Homo sapiens

<400>  789

Met Asn Arg Cys Pro Arg Arg Cys Arg Ser Pro Leu Gly Gln Ala Ala 
1               5                   10                  15      


Arg Ser Leu Tyr Gln Leu Val Thr Gly Ser Leu Ser Pro Asp Ser Val 
            20                  25                  30          


Asp Asp Glu Phe Glu Leu Ser Thr Val Cys His Arg Pro Glu Gly Leu 
        35                  40                  45              


Glu Gln Leu Gln Glu Gln Thr Lys Phe Thr Arg Lys Glu Leu Gln Val 
    50                  55                  60                  


Leu Tyr Arg Gly Phe Lys Asn Glu Cys Pro Ser Gly Ile Val Asn Glu 
65                  70                  75                  80  


Glu Asn Phe Lys Gln Ile Tyr Ser Gln Phe Phe Pro Gln Gly Asp Ser 
                85                  90                  95      


Ser Thr Tyr Ala Thr Phe Leu Phe Asn Ala Phe Asp Thr Asn His Asp 
            100                 105                 110         


Gly Ser Val Ser Phe Glu Asp Phe Val Ala Gly Leu Ser Val Ile Leu 
        115                 120                 125             


Arg Gly Thr Val Asp Asp Arg Leu Asn Trp Ala Phe Asn Leu Tyr Asp 
    130                 135                 140                 


Leu Asn Lys Asp Gly Cys Ile Thr Lys Glu Glu Met Leu Asp Ile Met 
145                 150                 155                 160 


Lys Ser Ile Tyr Asp Met Met Gly Lys Tyr Thr Tyr Pro Ala Leu Arg 
                165                 170                 175     


Glu Glu Ala Pro Arg Glu His Val Glu Ser Phe Phe Gln Lys Met Asp 
            180                 185                 190         


Arg Asn Lys Asp Gly Val Val Thr Ile Glu Glu Phe Ile Glu Ser Cys 
        195                 200                 205             


Gln Lys Asp Glu Asn Ile Met Arg Ser Met Gln Leu Phe Asp Asn Val 
    210                 215                 220                 


Ile 
225 


<210>  790
<211>  1419
<212>  DNA
<213>  Homo sapiens

<400>  790
agaggattca ttccaagggt ctgcttgtat tcaatgactg gtctacgtgg gggtgtgaag       60

tccccttact ccacctgtga agagtcttcc cagtttcaga ccaccctccc agcctcctgt      120

tattggctaa ggccattttg tgactacact gcaggtagag atggattcct ggaaatacct      180

cctcaaggcc agtgtagagc cctcaatcac ccactgcccc cagcttctcc ttctcccatc      240

tcctgcacca agcaggtctc caggtgttcc agctgctgat gacgtaaagt gtggagttgg      300

tccaggaagg tcatgttcca tgcagcagag gagcgctttg tgtgagaagt tgaagacctg      360

ctgtaacaca tcatagagga aagacatagc ctgggccttc tgcaactggc tgacttccac      420

cttctcctgg gggaatctga agtcacttct gtcctttaga cacaagaagg gagagattct      480

cctcatttgg cccaaaagca ccaaggtgtt cctgcctagc aggccatggt tctgaggcag      540

gttatatcct agagatccag aagagccaca gctgcacacc tctagggctg ccagtagagg      600

gaagaggagg gccattgaga aatcaggatg cttttggcct ggttgagctg aggtcttcat      660

agaaccttgg atcctaggtt ctatgaaaac attctatcta tgcatggctt taatggagca      720

caaatagttt tcatttttct gagcatttct ctaaattttt aattccattt attgttttca      780

tttacatgtc ttctatatca gcatccacaa ccttttggcc accagtttgg tggaagataa      840

tttttccacg aaaaatgggg tcagggaggg aatgctttca gaggcattag attctcatta      900

ggagaccaca acctagatcc ttcgcatctg cacttcacaa tagggttcct gctcttttga      960

gaatccaatg ccactgctga tctgacagga ggcagagctc aggcgttaat gcttgttggt     1020

tggcctgctt gcctcctgct gtgcggccct gttcctacca ggccaggacc agtaccccgg     1080

tccatggatg ggggttgaaa aaccttgttc tatatgacct aaaaggaggt catcactcta     1140

cactcttgat ttttgcaatg gatgttcaat attcccagta aacttaagat atatcaatcc     1200

aaatgaatat tgatcaatca gatgagaaac atctttgtgc tactgttaga agtatatact     1260

tttagcccag atcctagcct ccagttttac cctccatttt gcataggaaa tcaggatccc     1320

tgggccctat gggtttctgt attcagttag gaaattacct atctctggaa attaaacttt     1380

ttaggactaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaa                            1419


<210>  791
<211>  71
<212>  PRT
<213>  Homo sapiens

<400>  791

Met Asp Ser Trp Lys Tyr Leu Leu Lys Ala Ser Val Glu Pro Ser Ile 
1               5                   10                  15      


Thr His Cys Pro Gln Leu Leu Leu Leu Pro Ser Pro Ala Pro Ser Arg 
            20                  25                  30          


Ser Pro Gly Val Pro Ala Ala Asp Asp Val Lys Cys Gly Val Gly Pro 
        35                  40                  45              


Gly Arg Ser Cys Ser Met Gln Gln Arg Ser Ala Leu Cys Glu Lys Leu 
    50                  55                  60                  


Lys Thr Cys Cys Asn Thr Ser 
65                  70      


<210>  792
<211>  71
<212>  PRT
<213>  Homo sapiens

<400>  792

Met Asp Ser Trp Lys Tyr Leu Leu Lys Ala Ser Val Glu Pro Ser Ile 
1               5                   10                  15      


Thr His Cys Pro Gln Leu Leu Leu Leu Pro Ser Pro Ala Pro Ser Arg 
            20                  25                  30          


Ser Pro Gly Val Pro Ala Ala Asp Asp Val Lys Cys Gly Val Gly Pro 
        35                  40                  45              


Gly Arg Ser Cys Ser Met Gln Gln Arg Ser Ala Leu Cys Glu Lys Leu 
    50                  55                  60                  


Lys Thr Cys Cys Asn Thr Ser 
65                  70      


<210>  793
<211>  2052
<212>  DNA
<213>  Homo sapiens

<400>  793
ccgagttccc agcgcttgag aagggtcttc ctatgttgcc cgggctggtc ttgaactcct       60

gaactcaagc agtccttcca ccttggcctc ccaaagagct gggattacag gtgaaaattc      120

tggatctgtt atctgtgagg aggccactcc gttgacagtt gtgtaaaact ctgctgcttt      180

ccccagctcc aacctctctg gtcttcaaca acactatcat cagggaaaac gtgggggaag      240

atgaaccagc cgtgcaactc gatggagccg agggtgatgg acgatgacat gctcaagctg      300

gccgtcgggg accagggccc ccaggaggag gccgggcagc tggccaagca ggagggcatc      360

ctcttcaagg atgtcctgtc cctgcagctg gactttcgga acatcctccg catagacaac      420

ctctggcagt ttgagaactt gaggaagctg cagctggaca ataacatcat tgagaagatc      480

gagggcctgg agaacctcgc acacctggtc tggctggatc tgtctttcaa caacattgag      540

accatcgagg ggctggacac actggtgaac ctggaggacc tgagcttgtt caacaaccgg      600

atctccaaga tcgactccct ggacgccctc gtcaagctgc aggtgttgtc gctgggcaac      660

aaccggattg acaacatgat gaacatcatc tacctccggc ggttcaagtg cctgcggacg      720

ctcagcctct ctaggaaccc tatctctgag gcagaggatt acaagatgtt catctgtgcc      780

taccttcctg acctcatgta cctggactac cggcgcattg atgaccacac aaaaaagctt      840

gcggaggcta agcaccagta cagcatcgac gagctgaagc accaggagaa cctgatgcag      900

gcccagctgg aggacgagca ggcgcagcgg gaggagctag agaagcacaa gactgcgttt      960

gtggaacacc tgaatggctc cttcctgttt gacagcatgt acgctgagga ctcagagggc     1020

aacaatctgt cctacctgcc tggtgtcggt gagctccttg agacctacaa ggacaagttt     1080

gtcatcatct gcgtgaatat ttttgagtat ggcctgaaac agcaggagaa gcggaaaaca     1140

gagcttgaca ccttcagtga atgtgtccgt gaggccatcc aggaaaacca ggagcagggc     1200

aaacgcaaga ttgccaaatt cgaggagaag cacttgtcga gtttaagtgc cattcgagag     1260

gagttggaac tgcccaacat tgagaagatg atcctagaat gcagtgctga catcagtgag     1320

ttgttcgatg cgctcatgac gctggagatg cagctggtgg agcagctgga ggagactata     1380

aacatgtttg aaaggaacat tgttgacatg gtaggactgt ttatcgaaaa tgtccaaagc     1440

ctgatggctc agtgccggga cctggagaat caccaccacg agaagctcct ggagatctct     1500

atcagcaccc tggagaagat tgtcgagggc gacctggacg aggacctgcc taacgacctg     1560

cgcgcgcttt ttgtcgataa agatacgatt gttaatgctg tcggggcatc gcacgacatc     1620

cacctcctga agattgacaa tcgagaagat gagctggtga ccagaatcaa ctcttggtgt     1680

acacgtttaa tagacaggat tcacaaggat gagatcatga ggaaccgcaa gcgcgtgaag     1740

gagatcaatc agtacatcga ccacatgcag agcgaactgg acaacctgga atgtggcgac     1800

atcctagact agatgaatgt cagccacagg agcttcttca aaacatagca ccagccccag     1860

ccaggagaag gaagtgcaca cgcctcaccc gcacctctag agagttgctg ggcatctctc     1920

aaccgcgatc cccaacacca ttcttccccc acccctggaa aaacttccaa aagtagagaa     1980

aataaaggac tcatttcaca aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa     2040

aaaaaaaaaa aa                                                         2052


<210>  794
<211>  523
<212>  PRT
<213>  Homo sapiens

<400>  794

Met Asn Gln Pro Cys Asn Ser Met Glu Pro Arg Val Met Asp Asp Asp 
1               5                   10                  15      


Met Leu Lys Leu Ala Val Gly Asp Gln Gly Pro Gln Glu Glu Ala Gly 
            20                  25                  30          


Gln Leu Ala Lys Gln Glu Gly Ile Leu Phe Lys Asp Val Leu Ser Leu 
        35                  40                  45              


Gln Leu Asp Phe Arg Asn Ile Leu Arg Ile Asp Asn Leu Trp Gln Phe 
    50                  55                  60                  


Glu Asn Leu Arg Lys Leu Gln Leu Asp Asn Asn Ile Ile Glu Lys Ile 
65                  70                  75                  80  


Glu Gly Leu Glu Asn Leu Ala His Leu Val Trp Leu Asp Leu Ser Phe 
                85                  90                  95      


Asn Asn Ile Glu Thr Ile Glu Gly Leu Asp Thr Leu Val Asn Leu Glu 
            100                 105                 110         


Asp Leu Ser Leu Phe Asn Asn Arg Ile Ser Lys Ile Asp Ser Leu Asp 
        115                 120                 125             


Ala Leu Val Lys Leu Gln Val Leu Ser Leu Gly Asn Asn Arg Ile Asp 
    130                 135                 140                 


Asn Met Met Asn Ile Ile Tyr Leu Arg Arg Phe Lys Cys Leu Arg Thr 
145                 150                 155                 160 


Leu Ser Leu Ser Arg Asn Pro Ile Ser Glu Ala Glu Asp Tyr Lys Met 
                165                 170                 175     


Phe Ile Cys Ala Tyr Leu Pro Asp Leu Met Tyr Leu Asp Tyr Arg Arg 
            180                 185                 190         


Ile Asp Asp His Thr Lys Lys Leu Ala Glu Ala Lys His Gln Tyr Ser 
        195                 200                 205             


Ile Asp Glu Leu Lys His Gln Glu Asn Leu Met Gln Ala Gln Leu Glu 
    210                 215                 220                 


Asp Glu Gln Ala Gln Arg Glu Glu Leu Glu Lys His Lys Thr Ala Phe 
225                 230                 235                 240 


Val Glu His Leu Asn Gly Ser Phe Leu Phe Asp Ser Met Tyr Ala Glu 
                245                 250                 255     


Asp Ser Glu Gly Asn Asn Leu Ser Tyr Leu Pro Gly Val Gly Glu Leu 
            260                 265                 270         


Leu Glu Thr Tyr Lys Asp Lys Phe Val Ile Ile Cys Val Asn Ile Phe 
        275                 280                 285             


Glu Tyr Gly Leu Lys Gln Gln Glu Lys Arg Lys Thr Glu Leu Asp Thr 
    290                 295                 300                 


Phe Ser Glu Cys Val Arg Glu Ala Ile Gln Glu Asn Gln Glu Gln Gly 
305                 310                 315                 320 


Lys Arg Lys Ile Ala Lys Phe Glu Glu Lys His Leu Ser Ser Leu Ser 
                325                 330                 335     


Ala Ile Arg Glu Glu Leu Glu Leu Pro Asn Ile Glu Lys Met Ile Leu 
            340                 345                 350         


Glu Cys Ser Ala Asp Ile Ser Glu Leu Phe Asp Ala Leu Met Thr Leu 
        355                 360                 365             


Glu Met Gln Leu Val Glu Gln Leu Glu Glu Thr Ile Asn Met Phe Glu 
    370                 375                 380                 


Arg Asn Ile Val Asp Met Val Gly Leu Phe Ile Glu Asn Val Gln Ser 
385                 390                 395                 400 


Leu Met Ala Gln Cys Arg Asp Leu Glu Asn His His His Glu Lys Leu 
                405                 410                 415     


Leu Glu Ile Ser Ile Ser Thr Leu Glu Lys Ile Val Glu Gly Asp Leu 
            420                 425                 430         


Asp Glu Asp Leu Pro Asn Asp Leu Arg Ala Leu Phe Val Asp Lys Asp 
        435                 440                 445             


Thr Ile Val Asn Ala Val Gly Ala Ser His Asp Ile His Leu Leu Lys 
    450                 455                 460                 


Ile Asp Asn Arg Glu Asp Glu Leu Val Thr Arg Ile Asn Ser Trp Cys 
465                 470                 475                 480 


Thr Arg Leu Ile Asp Arg Ile His Lys Asp Glu Ile Met Arg Asn Arg 
                485                 490                 495     


Lys Arg Val Lys Glu Ile Asn Gln Tyr Ile Asp His Met Gln Ser Glu 
            500                 505                 510         


Leu Asp Asn Leu Glu Cys Gly Asp Ile Leu Asp 
        515                 520             


<210>  795
<211>  523
<212>  PRT
<213>  Homo sapiens

<400>  795

Met Asn Gln Pro Cys Asn Ser Met Glu Pro Arg Val Met Asp Asp Asp 
1               5                   10                  15      


Met Leu Lys Leu Ala Val Gly Asp Gln Gly Pro Gln Glu Glu Ala Gly 
            20                  25                  30          


Gln Leu Ala Lys Gln Glu Gly Ile Leu Phe Lys Asp Val Leu Ser Leu 
        35                  40                  45              


Gln Leu Asp Phe Arg Asn Ile Leu Arg Ile Asp Asn Leu Trp Gln Phe 
    50                  55                  60                  


Glu Asn Leu Arg Lys Leu Gln Leu Asp Asn Asn Ile Ile Glu Lys Ile 
65                  70                  75                  80  


Glu Gly Leu Glu Asn Leu Ala His Leu Val Trp Leu Asp Leu Ser Phe 
                85                  90                  95      


Asn Asn Ile Glu Thr Ile Glu Gly Leu Asp Thr Leu Val Asn Leu Glu 
            100                 105                 110         


Asp Leu Ser Leu Phe Asn Asn Arg Ile Ser Lys Ile Asp Ser Leu Asp 
        115                 120                 125             


Ala Leu Val Lys Leu Gln Val Leu Ser Leu Gly Asn Asn Arg Ile Asp 
    130                 135                 140                 


Asn Met Met Asn Ile Ile Tyr Leu Arg Arg Phe Lys Cys Leu Arg Thr 
145                 150                 155                 160 


Leu Ser Leu Ser Arg Asn Pro Ile Ser Glu Ala Glu Asp Tyr Lys Met 
                165                 170                 175     


Phe Ile Cys Ala Tyr Leu Pro Asp Leu Met Tyr Leu Asp Tyr Arg Arg 
            180                 185                 190         


Ile Asp Asp His Thr Lys Lys Leu Ala Glu Ala Lys His Gln Tyr Ser 
        195                 200                 205             


Ile Asp Glu Leu Lys His Gln Glu Asn Leu Met Gln Ala Gln Leu Glu 
    210                 215                 220                 


Asp Glu Gln Ala Gln Arg Glu Glu Leu Glu Lys His Lys Thr Ala Phe 
225                 230                 235                 240 


Val Glu His Leu Asn Gly Ser Phe Leu Phe Asp Ser Met Tyr Ala Glu 
                245                 250                 255     


Asp Ser Glu Gly Asn Asn Leu Ser Tyr Leu Pro Gly Val Gly Glu Leu 
            260                 265                 270         


Leu Glu Thr Tyr Lys Asp Lys Phe Val Ile Ile Cys Val Asn Ile Phe 
        275                 280                 285             


Glu Tyr Gly Leu Lys Gln Gln Glu Lys Arg Lys Thr Glu Leu Asp Thr 
    290                 295                 300                 


Phe Ser Glu Cys Val Arg Glu Ala Ile Gln Glu Asn Gln Glu Gln Gly 
305                 310                 315                 320 


Lys Arg Lys Ile Ala Lys Phe Glu Glu Lys His Leu Ser Ser Leu Ser 
                325                 330                 335     


Ala Ile Arg Glu Glu Leu Glu Leu Pro Asn Ile Glu Lys Met Ile Leu 
            340                 345                 350         


Glu Cys Ser Ala Asp Ile Ser Glu Leu Phe Asp Ala Leu Met Thr Leu 
        355                 360                 365             


Glu Met Gln Leu Val Glu Gln Leu Glu Glu Thr Ile Asn Met Phe Glu 
    370                 375                 380                 


Arg Asn Ile Val Asp Met Val Gly Leu Phe Ile Glu Asn Val Gln Ser 
385                 390                 395                 400 


Leu Met Ala Gln Cys Arg Asp Leu Glu Asn His His His Glu Lys Leu 
                405                 410                 415     


Leu Glu Ile Ser Ile Ser Thr Leu Glu Lys Ile Val Glu Gly Asp Leu 
            420                 425                 430         


Asp Glu Asp Leu Pro Asn Asp Leu Arg Ala Leu Phe Val Asp Lys Asp 
        435                 440                 445             


Thr Ile Val Asn Ala Val Gly Ala Ser His Asp Ile His Leu Leu Lys 
    450                 455                 460                 


Ile Asp Asn Arg Glu Asp Glu Leu Val Thr Arg Ile Asn Ser Trp Cys 
465                 470                 475                 480 


Thr Arg Leu Ile Asp Arg Ile His Lys Asp Glu Ile Met Arg Asn Arg 
                485                 490                 495     


Lys Arg Val Lys Glu Ile Asn Gln Tyr Ile Asp His Met Gln Ser Glu 
            500                 505                 510         


Leu Asp Asn Leu Glu Cys Gly Asp Ile Leu Asp 
        515                 520             


<210>  796
<211>  3509
<212>  DNA
<213>  Homo sapiens

<400>  796
gcatcagcat ccacccgctc tgcttcgccc tggagctcgc gccgctcagc agcctcaaca       60

ccgtgctgtc cgagaacgcc agagattctt cctttatacc cctgggacac atgctcaccc      120

aaaaaatagc ctaccagatc gcctcgggcc tggcctacct gcacaagaaa aacatcatct      180

tctgtgacct gaagtcggac aacattctgg tgtggtccct tgacgtcaag gagcacatca      240

acatcaagct atctgactac gggatttcga ggcagtcatt ccatgagggc gccctaggcg      300

tggagggcac tcctggctac caggccccag agatcaggcc tcgcattgta tatgatgaga      360

aggtagatat gttctcctat ggaatggtgc tctacgagtt gctgtcagga cagcgccctg      420

cactgggcca ccaccagctc cagattgcca agaagctgtc caagggcatc cgcccggttc      480

tggggcagcc ggaggaagtg cagttccggc gactgcaggc gctcatgatg gagtgctggg      540

acactaagcc agagaagcga ccgctggccc tgtcggtggt gagccagatg aaggacccga      600

cttttgccac cttcatgtat gaactgtgct gtgggaagca gacagccttc ttctcatccc      660

agggccagga gtacaccgtg gtgttttggg atggaaaaga ggagtccagg aactacacgg      720

tggtgaacac agagaagggc ctcatggagg tgcagaggat gtgctgccct gggatgaagg      780

tgagctgcca gctccaggtc cagagatccc tgtggacagc caccgaggac cagaaaatct      840

acatctacac cctcaagggc atgtgcccct taaacacacc ccaacaggcc ttggatactc      900

cagctgtcgt cacctgcttc ttggccgtgc ctgttattaa aaagaattcc tacctggtct      960

tagcgggcct cgccgatggg cttgtggctg tgtttcccgt ggtgcggggc accccaaagg     1020

acagctgctc ctacctgtgc tcacacacag ccaacaggtc caagttcagc atcgcggatg     1080

aagacgcacg gcagaacccc tacccagtga aggccatgga ggtggtcaac agcggctctg     1140

aggtctggta cagcaatggg ccgggcctcc ttgtcatcga ctgtgcctcc ctggagatct     1200

gcaggcggct ggagccctac atggccccct ccatggttac gtcagtcgtg tgcagctctg     1260

agggcagagg ggaggaggtc gtctggtgcc tggatgacaa ggccaactcc ttggtgatgt     1320

accactccac cacctaccag ctgtgtgccc ggtacttctg cggggtcccc agccccctca     1380

gggacatgtt tcccgtgcgg cccttggaca cggaaccccc ggcagccagc cacacggcca     1440

acccaaaggt gcctgagggg gactccatcg cggacgtgag catcatgtac agtgaggagc     1500

tgggcacgca gatcctgatc caccaggaat cactcactga ctactgctcc atgtcctcct     1560

actcctcatc cccaccccgc caggctgcca ggtccccctc aagcctcccc agctccccag     1620

caagttcttc cagtgtgcct ttctccaccg actgcgagga ctcagacatg ctacatatgc     1680

ccggtgctgc ctccgacagg tctgagcatg acctgacccc catggacggg gagaccttca     1740

gccagcacct gcaggccgtg aagatcctcg ccgtcagaga cctcatttgg gtccccaggc     1800

gcggtggaga tgttatcgtc attggcctgg agaaggattc tgaagcccag cggggccgag     1860

tcattgccgt cttaaaagcc cgagagctga ctccgcatgg gattatgcca gtctcctctg     1920

tgaaggtatg ctgggcaggg tggcctgtcc gggacatggt ctacatggct gcagtgatgt     1980

gaggctggcg ccagctgcag ctccccacag tgtttacacc ccgcactttg actaccgagc     2040

cccacacggg tgctggtgga tgctgccgtg gtggcaaagg acactgttgt gtgcaccttt     2100

gaaaatgaaa acacagagtg gtgcctggcc gtctggaggg gctggggcgc cagggagttc     2160

gacattttct accagtccta cgaggagctg ggccggctgg aggcttgcac tcgcaagaga     2220

aggtaattcc tgtggaatga ctgtcacaca tcagagctgg ctggcccggg gctgcagcct     2280

gacccctctg ccatcggcct ctagttctcc aaggacctag aagacagatg gagttctccc     2340

ctgaactcct tgctgctaag aagtgctgag aagttactcg cctggcggtg gctccagggt     2400

tctctggttc tctggagcag agttctctga ataccccatc ccccaactgc tgattttaca     2460

gccccaggga agacagtggt atcaggctgg gagcggcctc ctctggcctc ccccatcagt     2520

ttgcaggagc aggggtgcag gatcctgttc tgagctgggt caaacaaagc agggccgggc     2580

cttcctgcca tccccaggtc tcagatggaa ttacactaga ggccctccgc tgggaagcac     2640

ttgaggtagg gcaggagggg ggctgtgacc cctgcccttt ccccgccaga gacctcaggc     2700

tctcagcaca ttccacaggc tcctgagtcc ccgaggcctg ggccagcttg ggcaagccaa     2760

gatcagatgt ctctgtgttc gggaaggtct ccgtgtggga aagcccttgg gggatcccgg     2820

gtgaggagtg ttgccccatc cagagaatga atgagttcct ttaagtgcca ccgccagcaa     2880

gcccagaggc acacagtccg agtgcacccg cttagccttt acattcctct ccaccgacaa     2940

aaggaagggg aaactcaatc agcaggactt cagaaagggc cttgtgttta tagctttgtc     3000

aagtaaattt ggacgcagct ggagcacagg ccctgtttgt ttgcacataa taatcttgtt     3060

tatcacttta aaaaattcag taatatctca gcagtcaggc ttctggttgt gaaatcacat     3120

tgtatgggat ttataccaaa ttatgtattt gctaaacatt cactgcacac gtgtacagcg     3180

gagtacgaaa aggaacgttg tccacagggg atttatggat acaacagcaa acattttata     3240

aactatgcac atgcattaca cacatgcaca cacatatgca cacacatgtg caaacatagc     3300

cacttttttg tcaagagtta ccctttgggg ctccttaaac cagaatggga gtttgaaaga     3360

gagatcatac tccagctgaa gtttgttgac ccttttctaa aattaaaaag atcaaattta     3420

gtatttgctg gatatgcagg gagatgagac tcttttaatc tcaaaataaa cagattcttt     3480

caaaaaaaaa aaaaaaaaaa aaaaaaaaa                                       3509


<210>  797
<211>  2015
<212>  PRT
<213>  Homo sapiens

<400>  797

Met Ala Gly Met Ser Gln Arg Pro Pro Ser Met Tyr Trp Cys Val Gly 
1               5                   10                  15      


Pro Glu Glu Ser Ala Val Cys Pro Glu Arg Ala Met Glu Thr Leu Asn 
            20                  25                  30          


Gly Ala Gly Asp Thr Gly Gly Lys Pro Ser Thr Arg Gly Gly Asp Pro 
        35                  40                  45              


Ala Ala Arg Ser Arg Arg Thr Glu Gly Ile Arg Ala Ala Tyr Arg Arg 
    50                  55                  60                  


Gly Asp Arg Gly Gly Ala Arg Asp Leu Leu Glu Glu Ala Cys Asp Gln 
65                  70                  75                  80  


Cys Ala Ser Gln Leu Glu Lys Gly Gln Leu Leu Ser Ile Pro Ala Ala 
                85                  90                  95      


Tyr Gly Asp Leu Glu Met Val Arg Tyr Leu Leu Ser Lys Arg Leu Val 
            100                 105                 110         


Glu Leu Pro Thr Glu Pro Thr Asp Asp Asn Pro Ala Val Val Ala Ala 
        115                 120                 125             


Tyr Phe Gly His Thr Ala Val Val Gln Glu Leu Leu Glu Ser Leu Pro 
    130                 135                 140                 


Gly Pro Cys Ser Pro Gln Arg Leu Leu Asn Trp Met Leu Ala Leu Ala 
145                 150                 155                 160 


Cys Gln Arg Gly His Leu Gly Val Val Lys Leu Leu Val Leu Thr His 
                165                 170                 175     


Gly Ala Asp Pro Glu Ser Tyr Ala Val Arg Lys Asn Glu Phe Pro Val 
            180                 185                 190         


Ile Val Arg Leu Pro Leu Tyr Ala Ala Ile Lys Ser Gly Asn Glu Asp 
        195                 200                 205             


Ile Ala Ile Phe Leu Leu Arg His Gly Ala Tyr Phe Cys Ser Tyr Ile 
    210                 215                 220                 


Leu Leu Asp Ser Pro Asp Pro Ser Lys His Leu Leu Arg Lys Tyr Phe 
225                 230                 235                 240 


Ile Glu Ala Ser Pro Leu Pro Ser Ser Tyr Pro Gly Lys Thr Ala Leu 
                245                 250                 255     


Arg Val Lys Trp Ser His Leu Arg Leu Pro Trp Val Asp Leu Asp Trp 
            260                 265                 270         


Leu Ile Asp Ile Ser Cys Gln Ile Thr Glu Leu Asp Leu Ser Ala Asn 
        275                 280                 285             


Cys Leu Ala Thr Leu Pro Ser Val Ile Pro Trp Gly Leu Ile Asn Leu 
    290                 295                 300                 


Arg Lys Leu Asn Leu Ser Asp Asn His Leu Gly Glu Leu Pro Gly Val 
305                 310                 315                 320 


Gln Ser Ser Asp Glu Ile Ile Cys Ser Arg Leu Leu Glu Ile Asp Ile 
                325                 330                 335     


Ser Ser Asn Lys Leu Ser His Leu Pro Pro Gly Phe Leu His Leu Ser 
            340                 345                 350         


Lys Leu Gln Lys Leu Thr Ala Ser Lys Asn Cys Leu Glu Lys Leu Phe 
        355                 360                 365             


Glu Glu Glu Asn Ala Thr Asn Trp Ile Gly Leu Arg Lys Leu Gln Glu 
    370                 375                 380                 


Leu Asp Ile Ser Asp Asn Lys Leu Thr Glu Leu Pro Ala Leu Phe Leu 
385                 390                 395                 400 


His Ser Phe Lys Ser Leu Asn Ser Leu Asn Val Ser Arg Asn Asn Leu 
                405                 410                 415     


Lys Val Phe Pro Asp Pro Trp Ala Cys Pro Leu Lys Cys Cys Lys Ala 
            420                 425                 430         


Ser Arg Asn Ala Leu Glu Cys Leu Pro Asp Lys Met Ala Val Phe Trp 
        435                 440                 445             


Lys Asn His Leu Lys Asp Val Asp Phe Ser Glu Asn Ala Leu Lys Glu 
    450                 455                 460                 


Val Pro Leu Gly Leu Phe Gln Leu Asp Ala Leu Met Phe Leu Arg Leu 
465                 470                 475                 480 


Gln Gly Asn Gln Leu Ala Ala Leu Pro Pro Gln Glu Lys Trp Thr Cys 
                485                 490                 495     


Arg Gln Leu Lys Thr Leu Asp Leu Ser Arg Asn Gln Leu Gly Lys Asn 
            500                 505                 510         


Glu Asp Gly Leu Lys Thr Lys Arg Ile Ala Phe Phe Thr Thr Arg Gly 
        515                 520                 525             


Arg Gln Arg Ser Gly Thr Glu Ala Ala Ser Val Leu Glu Phe Pro Ala 
    530                 535                 540                 


Phe Leu Ser Glu Ser Leu Glu Val Leu Cys Leu Asn Asp Asn His Leu 
545                 550                 555                 560 


Asp Thr Val Pro Pro Ser Val Cys Leu Leu Lys Ser Leu Ser Glu Leu 
                565                 570                 575     


Tyr Leu Gly Asn Asn Pro Gly Leu Arg Glu Leu Pro Pro Glu Leu Gly 
            580                 585                 590         


Gln Leu Gly Asn Leu Trp Gln Leu Asp Thr Glu Asp Leu Thr Ile Ser 
        595                 600                 605             


Asn Val Pro Ala Glu Ile Gln Lys Glu Gly Pro Lys Ala Met Leu Ser 
    610                 615                 620                 


Tyr Leu Arg Ala Gln Leu Arg Lys Ala Glu Lys Cys Lys Leu Met Lys 
625                 630                 635                 640 


Met Ile Ile Val Gly Pro Pro Arg Gln Gly Lys Ser Thr Leu Leu Glu 
                645                 650                 655     


Ile Leu Gln Thr Gly Arg Ala Pro Gln Val Val His Gly Glu Ala Thr 
            660                 665                 670         


Ile Arg Thr Thr Lys Trp Glu Leu Gln Arg Pro Ala Gly Ser Arg Ala 
        675                 680                 685             


Lys Val Glu Ser Val Glu Phe Asn Val Trp Asp Ile Gly Gly Pro Ala 
    690                 695                 700                 


Ser Met Ala Thr Val Asn Gln Cys Phe Phe Thr Asp Lys Ala Leu Tyr 
705                 710                 715                 720 


Val Val Val Trp Asn Leu Ala Leu Gly Glu Glu Ala Val Ala Asn Leu 
                725                 730                 735     


Gln Phe Trp Leu Leu Asn Ile Glu Ala Lys Ala Pro Asn Ala Val Val 
            740                 745                 750         


Leu Val Val Gly Thr His Leu Asp Leu Ile Glu Ala Lys Phe Arg Val 
        755                 760                 765             


Glu Arg Ile Ala Thr Leu Arg Ala Tyr Val Leu Ala Leu Cys Arg Ser 
    770                 775                 780                 


Pro Ser Gly Ser Arg Ala Thr Gly Phe Pro Asp Ile Thr Phe Lys His 
785                 790                 795                 800 


Leu His Glu Ile Ser Cys Lys Ser Leu Glu Gly Gln Glu Gly Leu Arg 
                805                 810                 815     


Gln Leu Ile Phe His Val Thr Cys Ser Met Lys Asp Val Gly Ser Thr 
            820                 825                 830         


Ile Gly Cys Gln Arg Leu Ala Gly Arg Leu Ile Pro Arg Ser Tyr Leu 
        835                 840                 845             


Ser Leu Gln Glu Ala Val Leu Ala Glu Gln Gln Arg Arg Ser Arg Asp 
    850                 855                 860                 


Asp Asp Val Gln Tyr Leu Thr Asp Arg Gln Leu Glu Gln Leu Val Glu 
865                 870                 875                 880 


Gln Thr Pro Asp Asn Asp Ile Lys Asp Tyr Glu Asp Leu Gln Ser Ala 
                885                 890                 895     


Ile Ser Phe Leu Ile Glu Thr Gly Thr Leu Leu His Phe Pro Asp Thr 
            900                 905                 910         


Ser His Gly Leu Arg Asn Leu Tyr Phe Leu Asp Pro Ile Trp Leu Ser 
        915                 920                 925             


Glu Cys Leu Gln Arg Ile Phe Asn Ile Lys Gly Ser Arg Ser Val Ala 
    930                 935                 940                 


Lys Asn Gly Val Ile Arg Ala Glu Asp Leu Arg Met Leu Leu Val Gly 
945                 950                 955                 960 


Thr Gly Phe Thr Gln Gln Thr Glu Glu Gln Tyr Phe Gln Phe Leu Ala 
                965                 970                 975     


Lys Phe Glu Ile Ala Leu Pro Val Ala Asn Asp Ser Tyr Leu Leu Pro 
            980                 985                 990         


His Leu Leu Pro Ser Lys Pro Gly  Leu Asp Thr His Gly  Met Arg His 
        995                 1000                 1005             


Pro Thr  Ala Asn Thr Ile Gln  Arg Val Phe Lys Met  Ser Phe Val 
    1010                 1015                 1020             


Pro Val  Gly Phe Trp Gln Arg  Phe Ile Ala Arg Met  Leu Ile Ser 
    1025                 1030                 1035             


Leu Ala  Glu Met Asp Leu Gln  Leu Phe Glu Asn Lys  Lys Asn Thr 
    1040                 1045                 1050             


Lys Ser  Arg Asn Arg Lys Val  Thr Ile Tyr Ser Phe  Thr Gly Asn 
    1055                 1060                 1065             


Gln Arg  Asn Arg Cys Ser Thr  Phe Arg Val Lys Arg  Asn Gln Thr 
    1070                 1075                 1080             


Ile Tyr  Trp Gln Glu Gly Leu  Leu Val Thr Phe Asp  Gly Gly Tyr 
    1085                 1090                 1095             


Leu Ser  Val Glu Ser Ser Asp  Val Asn Trp Lys Lys  Lys Lys Ser 
    1100                 1105                 1110             


Gly Gly  Met Lys Ile Val Cys  Gln Ser Glu Val Arg  Asp Phe Ser 
    1115                 1120                 1125             


Ala Met  Ala Phe Ile Thr Asp  His Val Asn Ser Leu  Ile Asp Gln 
    1130                 1135                 1140             


Trp Phe  Pro Ala Leu Thr Ala  Thr Glu Ser Asp Gly  Thr Pro Leu 
    1145                 1150                 1155             


Met Glu  Gln Tyr Val Pro Cys  Pro Val Cys Glu Thr  Ala Trp Ala 
    1160                 1165                 1170             


Gln His  Thr Asp Pro Ser Glu  Lys Ser Glu Asp Val  Gln Tyr Phe 
    1175                 1180                 1185             


Asp Met  Glu Asp Cys Val Leu  Thr Ala Ile Glu Arg  Asp Phe Ile 
    1190                 1195                 1200             


Ser Cys  Pro Arg His Pro Asp  Leu Pro Val Pro Leu  Gln Glu Leu 
    1205                 1210                 1215             


Val Pro  Glu Leu Phe Met Thr  Asp Phe Pro Ala Arg  Leu Phe Leu 
    1220                 1225                 1230             


Glu Asn  Ser Lys Leu Glu His  Ser Glu Asp Glu Gly  Ser Val Leu 
    1235                 1240                 1245             


Gly Gln  Gly Gly Ser Gly Thr  Val Ile Tyr Arg Ala  Arg Tyr Gln 
    1250                 1255                 1260             


Gly Gln  Pro Val Ala Val Lys  Arg Phe His Ile Lys  Lys Phe Lys 
    1265                 1270                 1275             


Asn Phe  Ala Asn Val Pro Ala  Asp Thr Met Leu Arg  His Leu Arg 
    1280                 1285                 1290             


Ala Thr  Asp Ala Met Lys Asn  Phe Ser Glu Phe Arg  Gln Glu Ala 
    1295                 1300                 1305             


Ser Met  Leu His Ala Leu Gln  His Pro Cys Ile Val  Ala Leu Ile 
    1310                 1315                 1320             


Gly Ile  Ser Ile His Pro Leu  Cys Phe Ala Leu Glu  Leu Ala Pro 
    1325                 1330                 1335             


Leu Ser  Ser Leu Asn Thr Val  Leu Ser Glu Asn Ala  Arg Asp Ser 
    1340                 1345                 1350             


Ser Phe  Ile Pro Leu Gly His  Met Leu Thr Gln Lys  Ile Ala Tyr 
    1355                 1360                 1365             


Gln Ile  Ala Ser Gly Leu Ala  Tyr Leu His Lys Lys  Asn Ile Ile 
    1370                 1375                 1380             


Phe Cys  Asp Leu Lys Ser Asp  Asn Ile Leu Val Trp  Ser Leu Asp 
    1385                 1390                 1395             


Val Lys  Glu His Ile Asn Ile  Lys Leu Ser Asp Tyr  Gly Ile Ser 
    1400                 1405                 1410             


Arg Gln  Ser Phe His Glu Gly  Ala Leu Gly Val Glu  Gly Thr Pro 
    1415                 1420                 1425             


Gly Tyr  Gln Ala Pro Glu Ile  Arg Pro Arg Ile Val  Tyr Asp Glu 
    1430                 1435                 1440             


Lys Val  Asp Met Phe Ser Tyr  Gly Met Val Leu Tyr  Glu Leu Leu 
    1445                 1450                 1455             


Ser Gly  Gln Arg Pro Ala Leu  Gly His His Gln Leu  Gln Ile Ala 
    1460                 1465                 1470             


Lys Lys  Leu Ser Lys Gly Ile  Arg Pro Val Leu Gly  Gln Pro Glu 
    1475                 1480                 1485             


Glu Val  Gln Phe Arg Arg Leu  Gln Ala Leu Met Met  Glu Cys Trp 
    1490                 1495                 1500             


Asp Thr  Lys Pro Glu Lys Arg  Pro Leu Ala Leu Ser  Val Val Ser 
    1505                 1510                 1515             


Gln Met  Lys Asp Pro Thr Phe  Ala Thr Phe Met Tyr  Glu Leu Cys 
    1520                 1525                 1530             


Cys Gly  Lys Gln Thr Ala Phe  Phe Ser Ser Gln Gly  Gln Glu Tyr 
    1535                 1540                 1545             


Thr Val  Val Phe Trp Asp Gly  Lys Glu Glu Ser Arg  Asn Tyr Thr 
    1550                 1555                 1560             


Val Val  Asn Thr Glu Lys Gly  Leu Met Glu Val Gln  Arg Met Cys 
    1565                 1570                 1575             


Cys Pro  Gly Met Lys Val Ser  Cys Gln Leu Gln Val  Gln Arg Ser 
    1580                 1585                 1590             


Leu Trp  Thr Ala Thr Glu Asp  Gln Lys Ile Tyr Ile  Tyr Thr Leu 
    1595                 1600                 1605             


Lys Gly  Met Cys Pro Leu Asn  Thr Pro Gln Gln Ala  Leu Asp Thr 
    1610                 1615                 1620             


Pro Ala  Val Val Thr Cys Phe  Leu Ala Val Pro Val  Ile Lys Lys 
    1625                 1630                 1635             


Asn Ser  Tyr Leu Val Leu Ala  Gly Leu Ala Asp Gly  Leu Val Ala 
    1640                 1645                 1650             


Val Phe  Pro Val Val Arg Gly  Thr Pro Lys Asp Ser  Cys Ser Tyr 
    1655                 1660                 1665             


Leu Cys  Ser His Thr Ala Asn  Arg Ser Lys Phe Ser  Ile Ala Asp 
    1670                 1675                 1680             


Glu Asp  Ala Arg Gln Asn Pro  Tyr Pro Val Lys Ala  Met Glu Val 
    1685                 1690                 1695             


Val Asn  Ser Gly Ser Glu Val  Trp Tyr Ser Asn Gly  Pro Gly Leu 
    1700                 1705                 1710             


Leu Val  Ile Asp Cys Ala Ser  Leu Glu Ile Cys Arg  Arg Leu Glu 
    1715                 1720                 1725             


Pro Tyr  Met Ala Pro Ser Met  Val Thr Ser Val Val  Cys Ser Ser 
    1730                 1735                 1740             


Glu Gly  Arg Gly Glu Glu Val  Val Trp Cys Leu Asp  Asp Lys Ala 
    1745                 1750                 1755             


Asn Ser  Leu Val Met Tyr His  Ser Thr Thr Tyr Gln  Leu Cys Ala 
    1760                 1765                 1770             


Arg Tyr  Phe Cys Gly Val Pro  Ser Pro Leu Arg Asp  Met Phe Pro 
    1775                 1780                 1785             


Val Arg  Pro Leu Asp Thr Glu  Pro Pro Ala Ala Ser  His Thr Ala 
    1790                 1795                 1800             


Asn Pro  Lys Val Pro Glu Gly  Asp Ser Ile Ala Asp  Val Ser Ile 
    1805                 1810                 1815             


Met Tyr  Ser Glu Glu Leu Gly  Thr Gln Ile Leu Ile  His Gln Glu 
    1820                 1825                 1830             


Ser Leu  Thr Asp Tyr Cys Ser  Met Ser Ser Tyr Ser  Ser Ser Pro 
    1835                 1840                 1845             


Pro Arg  Gln Ala Ala Arg Ser  Pro Ser Ser Leu Pro  Ser Ser Pro 
    1850                 1855                 1860             


Ala Ser  Ser Ser Ser Val Pro  Phe Ser Thr Asp Cys  Glu Asp Ser 
    1865                 1870                 1875             


Asp Met  Leu His Thr Pro Gly  Ala Ala Ser Asp Arg  Ser Glu His 
    1880                 1885                 1890             


Asp Leu  Thr Pro Met Asp Gly  Glu Thr Phe Ser Gln  His Leu Gln 
    1895                 1900                 1905             


Ala Val  Lys Ile Leu Ala Val  Arg Asp Leu Ile Trp  Val Pro Arg 
    1910                 1915                 1920             


Arg Gly  Gly Asp Val Ile Val  Ile Gly Leu Glu Lys  Asp Ser Gly 
    1925                 1930                 1935             


Ala Gln  Arg Gly Arg Val Ile  Ala Val Leu Lys Ala  Arg Glu Leu 
    1940                 1945                 1950             


Thr Pro  His Gly Val Leu Val  Asp Ala Ala Val Val  Ala Lys Asp 
    1955                 1960                 1965             


Thr Val  Val Cys Thr Phe Glu  Asn Glu Asn Thr Glu  Trp Cys Leu 
    1970                 1975                 1980             


Ala Val  Trp Arg Gly Trp Gly  Ala Arg Glu Phe Asp  Ile Phe Tyr 
    1985                 1990                 1995             


Gln Ser  Tyr Glu Glu Leu Gly  Arg Leu Glu Ala Cys  Thr Arg Lys 
    2000                 2005                 2010             


Arg Arg  
    2015 


<210>  798
<211>  221
<212>  PRT
<213>  Homo sapiens

<400>  798

Met Tyr His Ser Thr Thr Tyr Gln Leu Cys Ala Arg Tyr Phe Cys Gly 
1               5                   10                  15      


Val Pro Ser Pro Leu Arg Asp Met Phe Pro Val Arg Pro Leu Asp Thr 
            20                  25                  30          


Glu Pro Pro Ala Ala Ser His Thr Ala Asn Pro Lys Val Pro Glu Gly 
        35                  40                  45              


Asp Ser Ile Ala Asp Val Ser Ile Met Tyr Ser Glu Glu Leu Gly Thr 
    50                  55                  60                  


Gln Ile Leu Ile His Gln Glu Ser Leu Thr Asp Tyr Cys Ser Met Ser 
65                  70                  75                  80  


Ser Tyr Ser Ser Ser Pro Pro Arg Gln Ala Ala Arg Ser Pro Ser Ser 
                85                  90                  95      


Leu Pro Ser Ser Pro Ala Ser Ser Ser Ser Val Pro Phe Ser Thr Asp 
            100                 105                 110         


Cys Glu Asp Ser Asp Met Leu His Met Pro Gly Ala Ala Ser Asp Arg 
        115                 120                 125             


Ser Glu His Asp Leu Thr Pro Met Asp Gly Glu Thr Phe Ser Gln His 
    130                 135                 140                 


Leu Gln Ala Val Lys Ile Leu Ala Val Arg Asp Leu Ile Trp Val Pro 
145                 150                 155                 160 


Arg Arg Gly Gly Asp Val Ile Val Ile Gly Leu Glu Lys Asp Ser Glu 
                165                 170                 175     


Ala Gln Arg Gly Arg Val Ile Ala Val Leu Lys Ala Arg Glu Leu Thr 
            180                 185                 190         


Pro His Gly Ile Met Pro Val Ser Ser Val Lys Val Cys Trp Ala Gly 
        195                 200                 205             


Trp Pro Val Arg Asp Met Val Tyr Met Ala Ala Val Met 
    210                 215                 220     


<210>  799
<211>  2319
<212>  DNA
<213>  Homo sapiens

<400>  799
gcaggggcgg ggcctgagtc agcgcagttc ggccggggtc tccccggcgc tgcccagtct       60

gtctccggcg ccgcccgtcg cggactcgtc cttgctgcag tcgccgccgc agtcctcgcc      120

gcagtcgccg ccgccgccgc cgccgccgcc gctgctcctc cgcctggcct gggccgtctg      180

cccgcagcca tgagcgtgct cggccccggt ggagcccgca gtcctctaga ttagtctcca      240

ccgccgtcca ggacccactt gcagcatgga gtcgcccgcc tcgagccagc ccgccagcat      300

gccccagtcc aaaggaaaat ccaagaggaa gaaggatcta cggatatcct gcatgtccaa      360

gccacccgca cccaacccca cacccccccg gaacctggac tcccggacct tcatcaccat      420

tggagacaga aactttgagg tggaggctga tgacttggtg accatctcag aactgggccg      480

tggagcctat ggggtggtag agaaggtgcg gcacgcccag agcggcacca tcatggccgt      540

gaagcggatc cgggccaccg tgaactcaca ggagcagaag cggctgctca tggacctgga      600

catcaacatg cgcacggtcg actgtttcta cactgtcacc ttctacgggg cactattcag      660

agagggagac gtgtggatct gcatggagct catggacaca tccttggaca agttctaccg      720

gaaggtgctg gataaaaaca tgacaattcc agaggacatc cttggggaga ttgctgtgtc      780

tatcgtgcgg gccctggagc atctgcacag caagctgtcg gtgatccaca gagatgtgaa      840

gccctccaat gtccttatca acaaggaggg ccatgtgaag atgtgtgact ttggcatcag      900

tggctacttg gtggactctg tggccaagac gatggatgcc ggctgcaagc cctacatggc      960

ccctgagagg atcaacccag agctgaacca gaagggctac aatgtcaagt ccgacgtctg     1020

gagcctgggc atcaccatga ttgagatggc catcctgcgg ttcccttacg agtcctgggg     1080

gaccccgttc cagcagctga agcaggtggt ggaggagccg tccccccagc tcccagccga     1140

ccgtttctcc cccgagtttg tggacttcac tgctcagtgc ctgaggaaga accccgcaga     1200

gcgtatgagc tacctggagc tgatggagca ccccttcttc accttgcaca aaaccaagaa     1260

gacggacatt gctgccttcg tgaaggagat cctgggagaa gactcatagg ggctgggcct     1320

cggaccccac tccggccctc cagagcccca cagccccatc tgcgggggca gtgctcaccc     1380

acaccataag ctactgccat cctggcccag ggcatctggg aggaaccgag ggggctgctc     1440

ccacctggct ctgtggcgag ccatttgtcc caagtgccaa agaagcagac cattggggct     1500

cccagccagg cccttgtcgg ccccaccagt gcctctccct gctgctccta ggacccgtct     1560

ccagctgctg agatcctgga ctgagggggc ctggatgccc cctgtggatg ctgctgcccc     1620

tgcacagcag gctgccagtg cctgggtgga tgggccaccg ccttgcccag cctggatgcc     1680

atccaagttg tatatttttt taatctctcg actgaatgga ctttgcacac tttggcccag     1740

ggtggccaca cctctatccc ggctttggtg cggggtacac aagaggggat gagttgtgtg     1800

aataccccaa gactcccatg agggagatgc catgagccgc ccaaggcctt cccctggcac     1860

tggcaaacag ggcctctgcg gagcacactg gctcacccag tcctgcccgc caccgttatc     1920

ggtgtcattc acctttcgtg ttttttttaa tttatcctct gttgattttt tcttttgctt     1980

tatgggtttg gcttgttttt cttgcatggt ttggagctga tcgcttctcc cccaccccct     2040

agggtaccag caggcagagc cttgccctct gctcaggctg gggtccagtg ggaggggccc     2100

aagatctctg ctcagagaag tgcaggggga gccttccagc tcactctccc tgaggactgg     2160

cttgacaggg gctatgggtt tgctttggtg ttgtttttaa aaaaagaaaa tatatttttt     2220

tgaaaaaacg actgcccatc ccgggtcctt tccctgatgg gttggggcag ttacctggtt     2280

gctgttttaa ttaaaaaaaa aaaaaaaaaa aggactaaa                            2319


<210>  800
<211>  347
<212>  PRT
<213>  Homo sapiens

<400>  800

Met Glu Ser Pro Ala Ser Ser Gln Pro Ala Ser Met Pro Gln Ser Lys 
1               5                   10                  15      


Gly Lys Ser Lys Arg Lys Lys Asp Leu Arg Ile Ser Cys Met Ser Lys 
            20                  25                  30          


Pro Pro Ala Pro Asn Pro Thr Pro Pro Arg Asn Leu Asp Ser Arg Thr 
        35                  40                  45              


Phe Ile Thr Ile Gly Asp Arg Asn Phe Glu Val Glu Ala Asp Asp Leu 
    50                  55                  60                  


Val Thr Ile Ser Glu Leu Gly Arg Gly Ala Tyr Gly Val Val Glu Lys 
65                  70                  75                  80  


Val Arg His Ala Gln Ser Gly Thr Ile Met Ala Val Lys Arg Ile Arg 
                85                  90                  95      


Ala Thr Val Asn Ser Gln Glu Gln Lys Arg Leu Leu Met Asp Leu Asp 
            100                 105                 110         


Ile Asn Met Arg Thr Val Asp Cys Phe Tyr Thr Val Thr Phe Tyr Gly 
        115                 120                 125             


Ala Leu Phe Arg Glu Gly Asp Val Trp Ile Cys Met Glu Leu Met Asp 
    130                 135                 140                 


Thr Ser Leu Asp Lys Phe Tyr Arg Lys Val Leu Asp Lys Asn Met Thr 
145                 150                 155                 160 


Ile Pro Glu Asp Ile Leu Gly Glu Ile Ala Val Ser Ile Val Arg Ala 
                165                 170                 175     


Leu Glu His Leu His Ser Lys Leu Ser Val Ile His Arg Asp Val Lys 
            180                 185                 190         


Pro Ser Asn Val Leu Ile Asn Lys Glu Gly His Val Lys Met Cys Asp 
        195                 200                 205             


Phe Gly Ile Ser Gly Tyr Leu Val Asp Ser Val Ala Lys Thr Met Asp 
    210                 215                 220                 


Ala Gly Cys Lys Pro Tyr Met Ala Pro Glu Arg Ile Asn Pro Glu Leu 
225                 230                 235                 240 


Asn Gln Lys Gly Tyr Asn Val Lys Ser Asp Val Trp Ser Leu Gly Ile 
                245                 250                 255     


Thr Met Ile Glu Met Ala Ile Leu Arg Phe Pro Tyr Glu Ser Trp Gly 
            260                 265                 270         


Thr Pro Phe Gln Gln Leu Lys Gln Val Val Glu Glu Pro Ser Pro Gln 
        275                 280                 285             


Leu Pro Ala Asp Arg Phe Ser Pro Glu Phe Val Asp Phe Thr Ala Gln 
    290                 295                 300                 


Cys Leu Arg Lys Asn Pro Ala Glu Arg Met Ser Tyr Leu Glu Leu Met 
305                 310                 315                 320 


Glu His Pro Phe Phe Thr Leu His Lys Thr Lys Lys Thr Asp Ile Ala 
                325                 330                 335     


Ala Phe Val Lys Glu Ile Leu Gly Glu Asp Ser 
            340                 345         


<210>  801
<211>  336
<212>  PRT
<213>  Homo sapiens

<400>  801

His Asn Gln Thr Ser Leu Tyr Lys Lys Ala Gly Ser Ala Ala Ala Pro 
1               5                   10                  15      


Phe Thr Met Ser Lys Pro Pro Ala Pro Asn Pro Thr Pro Pro Arg Asn 
            20                  25                  30          


Leu Asp Ser Arg Thr Phe Ile Thr Ile Gly Asp Arg Asn Phe Glu Val 
        35                  40                  45              


Glu Ala Asp Asp Leu Val Thr Ile Ser Glu Leu Gly Arg Gly Ala Tyr 
    50                  55                  60                  


Gly Val Val Glu Lys Val Arg His Ala Gln Ser Gly Thr Ile Met Ala 
65                  70                  75                  80  


Val Lys Arg Ile Arg Ala Thr Val Asn Ser Gln Glu Gln Lys Arg Leu 
                85                  90                  95      


Leu Met Asp Leu Asp Ile Asn Met Arg Thr Val Asp Cys Phe Tyr Thr 
            100                 105                 110         


Val Thr Phe Tyr Gly Ala Leu Phe Arg Glu Gly Asp Val Trp Ile Cys 
        115                 120                 125             


Met Glu Leu Met Asp Thr Ser Leu Asp Lys Phe Tyr Arg Lys Val Leu 
    130                 135                 140                 


Asp Lys Asn Met Thr Ile Pro Glu Asp Ile Leu Gly Glu Ile Ala Val 
145                 150                 155                 160 


Ser Ile Val Arg Ala Leu Glu His Leu His Ser Lys Leu Ser Val Ile 
                165                 170                 175     


His Arg Asp Val Lys Pro Ser Asn Val Leu Ile Asn Lys Glu Gly His 
            180                 185                 190         


Val Lys Met Cys Asp Phe Gly Ile Ser Gly Tyr Leu Val Asp Ser Val 
        195                 200                 205             


Ala Lys Thr Met Asp Ala Gly Cys Lys Pro Tyr Met Ala Pro Glu Arg 
    210                 215                 220                 


Ile Asn Pro Glu Leu Asn Gln Lys Gly Tyr Asn Val Lys Ser Asp Val 
225                 230                 235                 240 


Trp Ser Leu Gly Ile Thr Met Ile Glu Met Ala Ile Leu Arg Phe Pro 
                245                 250                 255     


Tyr Glu Ser Trp Gly Thr Pro Phe Gln Gln Leu Lys Gln Val Val Glu 
            260                 265                 270         


Glu Pro Ser Pro Gln Leu Pro Ala Asp Arg Phe Ser Pro Glu Phe Val 
        275                 280                 285             


Asp Phe Thr Ala Gln Cys Leu Arg Lys Asn Pro Ala Glu Arg Met Ser 
    290                 295                 300                 


Tyr Leu Glu Leu Met Glu His Pro Phe Phe Thr Leu His Lys Thr Lys 
305                 310                 315                 320 


Lys Thr Asp Ile Ala Ala Phe Val Lys Glu Ile Leu Gly Glu Asp Ser 
                325                 330                 335     


<210>  802
<211>  4336
<212>  DNA
<213>  Homo sapiens

<400>  802
gcggcggcgg cagcggcgga gaagggagcg ggaccggaag ggtcgcagcg ccccggcgcc       60

cctcacaccc actgcggcgg cggcggcggc ggcggcggcg gggcggagcg gagcggggcg      120

ggccggcggc ggagccgggg ccgcggagcc aggagtgact agcacgcagc gccgccagtc      180

cgcccgcccg ccctctcccc gtggcgcggc ggcggggagg cgagggatct gaaacttgcc      240

cacccttcgg gatattgcag gacgctgcat catgagcgac agtaaatgtg acagtcagtt      300

ttatagtgtg caagtggcag actcaacctt cactgtccta aaacgttacc agcagctgaa      360

accaattggc tctggggccc aagggattgt ttgtgctgca tttgatacag ttcttgggat      420

aaatgttgca gtcaagaaac taagccgtcc ttttcagaac caaactcatg caaagagagc      480

ttatcgtgaa cttgtcctct taaaatgtgt caatcataaa aatataatta gtttgttaaa      540

tgtgtttaca ccacaaaaaa ctctagaaga atttcaagat gtgtatttgg ttatggaatt      600

aatggatgct aacttatgtc aggttattca catggagctg gatcatgaaa gaatgtccta      660

ccttctttac cagatgcttt gtggtattaa acatctgcat tcagctggta taattcatag      720

agatttgaag cctagcaaca ttgttgtgaa atcagactgc accctgaaga tccttgactt      780

tggcctggcc cggacagcgt gcactaactt catgatgacc ccttacgtgg tgacacggta      840

ctaccgggcg cccgaagtca tcctgggtat gggctacaaa gagaacgttg atatctggtc      900

agtgggttgc atcatgggag agctggtgaa aggttgtgtg atattccaag gcactgacca      960

tattgatcag tggaataaag ttattgagca gctgggaaca ccatcagcag agttcatgaa     1020

gaaacttcag ccaactgtga ggaattatgt cgaaaacaga ccaaagtatc ctggaatcaa     1080

atttgaagaa ctctttccag attggatatt cccatcagaa tctgagcgag acaaaataaa     1140

aacaagtcaa gccagagatc tgttatcaaa aatgttagtg attgatcctg acaagcggat     1200

ctctgtagac gaagctctgc gtcacccata catcactgtt tggtatgacc ccgccgaagc     1260

agaagcccca ccacctcaaa tttatgatgc ccagttggaa gaaagagaac atgcaattga     1320

agaatggaaa gagctaattt acaaagaagt catggattgg gaagaaagaa gcaagaatgg     1380

tgttgtaaaa gatcagcctt cagatgcagc agtaagtagc aacgccactc cttctcagtc     1440

ttcatcgatc aatgacattt catccatgtc cactgagcag acgctggcct cagacacaga     1500

cagcagtctt gatgcctcga cgggacccct tgaaggctgt cgatgatagg ttagaaatag     1560

caaacctgtc agcattgaag gaactctcac ctccgtgggc ctgaaatgct tgggagttga     1620

tggaaccaaa tagaaaaact ccatgttctg catgtaagaa acacaatgcc ttgccctact     1680

cagacctgat aggattgcct gcttagatga taaaatgagg cagaatatgt ctgaagaaaa     1740

aaattgcaag ccacacttct agagattttg ttcaagatca tttcaggtga gcagttagag     1800

taggtgaatt tgtttcaaat tgtactagtg acagtttctc atcatctgta actgttgaga     1860

tgtatgtgca tgtgaccaca aatgcttgct tggacttgcc catctagcac tttggaaatc     1920

agtatttaaa tgccaaataa tcttccaggt agtgctgctt ctgaagttat ctcttaatcc     1980

tcttaagtaa tttggtgtct gtccagaaaa agtcgattta tgtgtattaa ttggccatca     2040

tgatgttatc atatcttatt cccttttatg ctatgattta ttctatcttt tgtatttcag     2100

aagacatata attaaatcta tttaataaat aaaaatatat agcttttctt agatttgtga     2160

tgtttggggc tgagaattat cacggctaaa accaagacac ttatgtggac atcttgtttt     2220

ctttaaactg tcttgtctgg gatgattgta cattcagctt tactgcacga tacaatttta     2280

agttttgctt agtgctgctt gaaatcctag ctaccttatc tcttttcttc ttggtcttct     2340

agacttctta tgaatttaaa atgctaccta gaacttcacc ttctttatta ggtgcgtaac     2400

actccatctt aattaaatat gatggcagat aggttcctgc atccatggcc taacgttgga     2460

gtggaatttt acaaaatgct cactagagat cactgcagtc atttcctaag tgcttccttt     2520

gccacagact ggcctgggtc ctttatttac cttccctcat tcactttccc tcggccaata     2580

ccacgttctt gattttcttt cttcactgga agaaagcaga taaactcctc tttggtctgt     2640

tttcagaggc caggctgatt cagatgcctg ttgctattgt tgctctccat tgttgggagg     2700

cattcctttt cacaagaatg ttctgggaaa ctcttcagag gacgtgaagg aaataccctg     2760

aagagtcatg attaactatt gactattttc tgatttaaaa ctgctcacct gaaattgata     2820

cttttagact ttacgatcag taaattattc agaattcatg aagatgctga gtatgttaag     2880

tgtcactgca ggaacggagc tgtggtgatc acgttttgcc tgcctgtgcc catgtctctt     2940

cccttgagct tattctgttg ctgattcata tcttgtgttc aattattttg gaagcttttc     3000

agtcgacatt ctgtagagtg tgttctgagg aggaactgtg ataagaaagt ttattataaa     3060

tattatgtaa aatatatggc tctctctgca ccagttatat cttattggtt ggtcatatca     3120

ctggaaactg gaacctttga ttagcaaaat taatattgaa ataagaaata gttcttttat     3180

attgtgtcat ttggacactt tcaagtacaa aatggtaata ataacttgga ttgaggcgga     3240

aacacctatt ttatggctat ctatctaaac atcttaaaat ggccttctct gtaatacact     3300

ttcttttaaa agacttcact aaatctatct ttaaaaggaa aaacaaaagg gagaggttga     3360

aaatgcgcga gctgccctgc actgtgtgat gctccctccc cgggagacgt ggacggggga     3420

cgaggcaccc gcagacgccc ttctgctcac tcgctcctct gtgcattcag cgagccactt     3480

gccacagatg gagcccgtga cggtgtggag ggtttcctgg aaaggccatc ttccaccagg     3540

tagaggcgag cgtgcctagg acaggccaca gggctccaca gaaatacctc accccagctt     3600

cagggttctc tctcctgagc ctagatttgc cagggtcttg gtgccacgca aatggtttca     3660

aactgatctc tatggataaa tgctgatgtt ggttaaagaa ctgaaaaatg tgctcaactg     3720

tttcatcttt tctattttat ttttgtaatt tatattgtac acaacccagg aagtaactat     3780

tttggacatg tatttttata aaccaggtaa tttactatta tcctggaatt tagactaggt     3840

ttgtttcatt tgttgactta gtttccagcc aagaaggaaa cgactgtctc ccccatgtcc     3900

aggtctcagt ttcaagggca gagtccagag agcagacaga gttctgtgag agcaggagag     3960

cagtctggaa accctggctg tgcataccgt gtcagccgtg ggcctggaga tgggagcagg     4020

tgagacgcag agccccagta ctgagaggag gaagccctct tacagggccc cttgcccacc     4080

ccaagtccgt gtctgaaaca cggagcgggt gctgcttcaa cccgcattta atgctgtgta     4140

agtagcgata accacgtacg agtctgtctg gttgatttct aatgtgactc ctctggtatt     4200

tcctcctggt aataaataca agtgtgacct ttcagattgc atatctcaaa agtaacattg     4260

ctaatgtttt ataataaaat atattatgtg tgttttggtt ggtgaaaata atacagacta     4320

cattttaaaa gataaa                                                     4336


<210>  803
<211>  424
<212>  PRT
<213>  Homo sapiens

<400>  803

Met Ser Asp Ser Lys Cys Asp Ser Gln Phe Tyr Ser Val Gln Val Ala 
1               5                   10                  15      


Asp Ser Thr Phe Thr Val Leu Lys Arg Tyr Gln Gln Leu Lys Pro Ile 
            20                  25                  30          


Gly Ser Gly Ala Gln Gly Ile Val Cys Ala Ala Phe Asp Thr Val Leu 
        35                  40                  45              


Gly Ile Asn Val Ala Val Lys Lys Leu Ser Arg Pro Phe Gln Asn Gln 
    50                  55                  60                  


Thr His Ala Lys Arg Ala Tyr Arg Glu Leu Val Leu Leu Lys Cys Val 
65                  70                  75                  80  


Asn His Lys Asn Ile Ile Ser Leu Leu Asn Val Phe Thr Pro Gln Lys 
                85                  90                  95      


Thr Leu Glu Glu Phe Gln Asp Val Tyr Leu Val Met Glu Leu Met Asp 
            100                 105                 110         


Ala Asn Leu Cys Gln Val Ile His Met Glu Leu Asp His Glu Arg Met 
        115                 120                 125             


Ser Tyr Leu Leu Tyr Gln Met Leu Cys Gly Ile Lys His Leu His Ser 
    130                 135                 140                 


Ala Gly Ile Ile His Arg Asp Leu Lys Pro Ser Asn Ile Val Val Lys 
145                 150                 155                 160 


Ser Asp Cys Thr Leu Lys Ile Leu Asp Phe Gly Leu Ala Arg Thr Ala 
                165                 170                 175     


Cys Thr Asn Phe Met Met Thr Pro Tyr Val Val Thr Arg Tyr Tyr Arg 
            180                 185                 190         


Ala Pro Glu Val Ile Leu Gly Met Gly Tyr Lys Glu Asn Val Asp Ile 
        195                 200                 205             


Trp Ser Val Gly Cys Ile Met Gly Glu Leu Val Lys Gly Cys Val Ile 
    210                 215                 220                 


Phe Gln Gly Thr Asp His Ile Asp Gln Trp Asn Lys Val Ile Glu Gln 
225                 230                 235                 240 


Leu Gly Thr Pro Ser Ala Glu Phe Met Lys Lys Leu Gln Pro Thr Val 
                245                 250                 255     


Arg Asn Tyr Val Glu Asn Arg Pro Lys Tyr Pro Gly Ile Lys Phe Glu 
            260                 265                 270         


Glu Leu Phe Pro Asp Trp Ile Phe Pro Ser Glu Ser Glu Arg Asp Lys 
        275                 280                 285             


Ile Lys Thr Ser Gln Ala Arg Asp Leu Leu Ser Lys Met Leu Val Ile 
    290                 295                 300                 


Asp Pro Asp Lys Arg Ile Ser Val Asp Glu Ala Leu Arg His Pro Tyr 
305                 310                 315                 320 


Ile Thr Val Trp Tyr Asp Pro Ala Glu Ala Glu Ala Pro Pro Pro Gln 
                325                 330                 335     


Ile Tyr Asp Ala Gln Leu Glu Glu Arg Glu His Ala Ile Glu Glu Trp 
            340                 345                 350         


Lys Glu Leu Ile Tyr Lys Glu Val Met Asp Trp Glu Glu Arg Ser Lys 
        355                 360                 365             


Asn Gly Val Val Lys Asp Gln Pro Ser Asp Ala Ala Val Ser Ser Asn 
    370                 375                 380                 


Ala Thr Pro Ser Gln Ser Ser Ser Ile Asn Asp Ile Ser Ser Met Ser 
385                 390                 395                 400 


Thr Glu Gln Thr Leu Ala Ser Asp Thr Asp Ser Ser Leu Asp Ala Ser 
                405                 410                 415     


Thr Gly Pro Leu Glu Gly Cys Arg 
            420                 


<210>  804
<211>  458
<212>  PRT
<213>  Homo sapiens

<400>  804

Met Ser Tyr Tyr His His His His His His Asp Tyr Asp Ile Pro Thr 
1               5                   10                  15      


Thr Glu Asn Leu Tyr Phe Gln Gly Ile Thr Ser Leu Tyr Lys Lys Ala 
            20                  25                  30          


Gly Thr Met Ser Asp Ser Lys Cys Asp Ser Gln Phe Tyr Ser Val Gln 
        35                  40                  45              


Val Ala Asp Ser Thr Phe Thr Val Leu Lys Arg Tyr Gln Gln Leu Lys 
    50                  55                  60                  


Pro Ile Gly Ser Gly Ala Gln Gly Ile Val Cys Ala Ala Phe Asp Thr 
65                  70                  75                  80  


Val Leu Gly Ile Asn Val Ala Val Lys Lys Leu Ser Arg Pro Phe Gln 
                85                  90                  95      


Asn Gln Thr His Ala Lys Arg Ala Tyr Arg Glu Leu Val Leu Leu Lys 
            100                 105                 110         


Cys Val Asn His Lys Asn Ile Ile Ser Leu Leu Asn Val Phe Thr Pro 
        115                 120                 125             


Gln Lys Thr Leu Glu Glu Phe Gln Asp Val Tyr Leu Val Met Glu Leu 
    130                 135                 140                 


Met Asp Ala Asn Leu Cys Gln Val Ile His Met Glu Leu Asp His Glu 
145                 150                 155                 160 


Arg Met Ser Tyr Leu Leu Tyr Gln Met Leu Cys Gly Ile Lys His Leu 
                165                 170                 175     


His Ser Ala Gly Ile Ile His Arg Asp Leu Lys Pro Ser Asn Ile Val 
            180                 185                 190         


Val Lys Ser Asp Cys Thr Leu Lys Ile Leu Asp Phe Gly Leu Ala Arg 
        195                 200                 205             


Thr Ala Cys Thr Asn Phe Met Met Thr Pro Tyr Val Val Thr Arg Tyr 
    210                 215                 220                 


Tyr Arg Ala Pro Glu Val Ile Leu Gly Met Gly Tyr Lys Glu Asn Val 
225                 230                 235                 240 


Asp Ile Trp Ser Val Gly Cys Ile Met Gly Glu Leu Val Lys Gly Cys 
                245                 250                 255     


Val Ile Phe Gln Gly Thr Asp His Ile Asp Gln Trp Asn Lys Val Ile 
            260                 265                 270         


Glu Gln Leu Gly Thr Pro Ser Ala Glu Phe Met Lys Lys Leu Gln Pro 
        275                 280                 285             


Thr Val Arg Asn Tyr Val Glu Asn Arg Pro Lys Tyr Pro Gly Ile Lys 
    290                 295                 300                 


Phe Glu Glu Leu Phe Pro Asp Trp Ile Phe Pro Ser Glu Ser Glu Arg 
305                 310                 315                 320 


Asp Lys Ile Lys Thr Ser Gln Ala Arg Asp Leu Leu Ser Lys Met Leu 
                325                 330                 335     


Val Ile Asp Pro Asp Lys Arg Ile Ser Val Asp Glu Ala Leu Arg His 
            340                 345                 350         


Pro Tyr Ile Thr Val Trp Tyr Asp Pro Ala Glu Ala Glu Ala Pro Pro 
        355                 360                 365             


Pro Gln Ile Tyr Asp Ala Gln Leu Glu Glu Arg Glu His Ala Ile Glu 
    370                 375                 380                 


Glu Trp Lys Glu Leu Ile Tyr Lys Glu Val Met Asp Trp Glu Glu Arg 
385                 390                 395                 400 


Ser Lys Asn Gly Val Val Lys Asp Gln Pro Ser Asp Ala Ala Val Ser 
                405                 410                 415     


Ser Asn Ala Thr Pro Ser Gln Ser Ser Ser Ile Asn Asp Ile Ser Ser 
            420                 425                 430         


Met Ser Thr Glu Gln Thr Leu Ala Ser Asp Thr Asp Ser Ser Leu Asp 
        435                 440                 445             


Ala Ser Thr Gly Pro Leu Glu Gly Cys Arg 
    450                 455             


<210>  805
<211>  1499
<212>  DNA
<213>  Homo sapiens

<400>  805
gcctcggtcg ccacggtaac gcgcgcgggc aggtgtccga ccatgagcgt ccgggtcgca       60

cgggtagcgt gggtcagggg cttgggcgcc agctaccgcc gcggcgcctc gagcttcccg      120

gtgcctccgc cgggcgccca gggtgtagcg gagctgctgc gagatgcgac cggggcggag      180

gaggaggcgc cctgggcggc gacggagcgg cgaatgccgg gccagtgctc cgtgctgctc      240

ttcccgggcc agggcagcca ggtggtgggc atgggccgcg gtctgctcaa ctacccgcgc      300

gtccgcgaac tctacgccgc cgcccgccgc gtgctgggct acgacctgct ggaactgagc      360

ctgcacgggc cgcaggagac cctggaccgc accgtgcact gtcagcccgc gatcttcgtg      420

gcatcgctgg ccgctgtcga gaaactacat cacctgcagc cctcggtgat tgagaactgt      480

gttgctgctg ctggattcag tgtgggagag tttgcagccc tagtgtttgc cggagccatg      540

gaatttgctg aaggtttgta tgcagtgaaa atccgagctg aggccatgca ggaagcttca      600

gaagctgtcc ccagtgggat gctgtctgtc ctcggccagc ctcagtccaa gttcaacttc      660

gcctgtttgg aagcccggga acactgcaag tctttaggca tagagaaccc cgtatgtgaa      720

gtgtccaact acctctttcc agattgcagg gtgatttcag gacaccaaga ggctctacgg      780

tttctccaga agaattcctc taagtttcat ttcagacgca ccaggatgtt gccggttagt      840

ggcgcattcc acacccgcct catggagcca gccgtggagc ccctgacgca agctttaaag      900

gcagtcgaca ttaagaagcc tctggtttct gtctactcca acgtccacgg gcatagatac      960

aggcatcccg ggcacatcca caagctgctg gcccagcagc tggtctcccc agtgaagtgg     1020

gagcagacga tgcatgccat atacgaaagg aaaaagggca gggggttccc ccaaactttc     1080

gaagtaggcc ctggcaggca gctgggagcc atcctgaaga gctgtaacat gcaggcctgg     1140

aagtcctaca gcgccgtgga tgtgctgcag accctcgaac atgtggacct ggaccctcag     1200

gagcccccga gatgactgca gggggctcaa atgcaatgac cccctctgtc ctcctgagga     1260

gaggctgtag gctgtgcctg tcgcccccta ccttcctaat ggctcctcct ctgaggagtg     1320

aaagggattt gtttgcaacg tgctttgaag gccacataaa aagccctaaa aatgaaaaaa     1380

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa     1440

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaa      1499


<210>  806
<211>  390
<212>  PRT
<213>  Homo sapiens

<400>  806

Met Ser Val Arg Val Ala Arg Val Ala Trp Val Arg Gly Leu Gly Ala 
1               5                   10                  15      


Ser Tyr Arg Arg Gly Ala Ser Ser Phe Pro Val Pro Pro Pro Gly Ala 
            20                  25                  30          


Gln Gly Val Ala Glu Leu Leu Arg Asp Ala Thr Gly Ala Glu Glu Glu 
        35                  40                  45              


Ala Pro Trp Ala Ala Thr Glu Arg Arg Met Pro Gly Gln Cys Ser Val 
    50                  55                  60                  


Leu Leu Phe Pro Gly Gln Gly Ser Gln Val Val Gly Met Gly Arg Gly 
65                  70                  75                  80  


Leu Leu Asn Tyr Pro Arg Val Arg Glu Leu Tyr Ala Ala Ala Arg Arg 
                85                  90                  95      


Val Leu Gly Tyr Asp Leu Leu Glu Leu Ser Leu His Gly Pro Gln Glu 
            100                 105                 110         


Thr Leu Asp Arg Thr Val His Cys Gln Pro Ala Ile Phe Val Ala Ser 
        115                 120                 125             


Leu Ala Ala Val Glu Lys Leu His His Leu Gln Pro Ser Val Ile Glu 
    130                 135                 140                 


Asn Cys Val Ala Ala Ala Gly Phe Ser Val Gly Glu Phe Ala Ala Leu 
145                 150                 155                 160 


Val Phe Ala Gly Ala Met Glu Phe Ala Glu Gly Leu Tyr Ala Val Lys 
                165                 170                 175     


Ile Arg Ala Glu Ala Met Gln Glu Ala Ser Glu Ala Val Pro Ser Gly 
            180                 185                 190         


Met Leu Ser Val Leu Gly Gln Pro Gln Ser Lys Phe Asn Phe Ala Cys 
        195                 200                 205             


Leu Glu Ala Arg Glu His Cys Lys Ser Leu Gly Ile Glu Asn Pro Val 
    210                 215                 220                 


Cys Glu Val Ser Asn Tyr Leu Phe Pro Asp Cys Arg Val Ile Ser Gly 
225                 230                 235                 240 


His Gln Glu Ala Leu Arg Phe Leu Gln Lys Asn Ser Ser Lys Phe His 
                245                 250                 255     


Phe Arg Arg Thr Arg Met Leu Pro Val Ser Gly Ala Phe His Thr Arg 
            260                 265                 270         


Leu Met Glu Pro Ala Val Glu Pro Leu Thr Gln Ala Leu Lys Ala Val 
        275                 280                 285             


Asp Ile Lys Lys Pro Leu Val Ser Val Tyr Ser Asn Val His Ala His 
    290                 295                 300                 


Arg Tyr Arg His Pro Gly His Ile His Lys Leu Leu Ala Gln Gln Leu 
305                 310                 315                 320 


Val Ser Pro Val Lys Trp Glu Gln Thr Met His Ala Ile Tyr Glu Arg 
                325                 330                 335     


Lys Lys Gly Arg Gly Phe Pro Gln Thr Phe Glu Val Gly Pro Gly Arg 
            340                 345                 350         


Gln Leu Gly Ala Ile Leu Lys Ser Cys Asn Met Gln Ala Trp Lys Ser 
        355                 360                 365             


Tyr Ser Ala Val Asp Val Leu Gln Thr Leu Glu His Val Asp Leu Asp 
    370                 375                 380                 


Pro Gln Glu Pro Pro Arg 
385                 390 


<210>  807
<211>  333
<212>  PRT
<213>  Homo sapiens

<400>  807

Met Pro Gly Gln Cys Ser Val Leu Leu Phe Pro Gly Gln Gly Ser Gln 
1               5                   10                  15      


Val Val Gly Met Gly Arg Gly Leu Leu Asn Tyr Pro Arg Val Arg Glu 
            20                  25                  30          


Leu Tyr Ala Ala Ala Arg Arg Val Leu Gly Tyr Asp Leu Leu Glu Leu 
        35                  40                  45              


Ser Leu His Gly Pro Gln Glu Thr Leu Asp Arg Thr Val His Cys Gln 
    50                  55                  60                  


Pro Ala Ile Phe Val Ala Ser Leu Ala Ala Val Glu Lys Leu His His 
65                  70                  75                  80  


Leu Gln Pro Ser Val Ile Glu Asn Cys Val Ala Ala Ala Gly Phe Ser 
                85                  90                  95      


Val Gly Glu Phe Ala Ala Leu Val Phe Ala Gly Ala Met Glu Phe Ala 
            100                 105                 110         


Glu Gly Leu Tyr Ala Val Lys Ile Arg Ala Glu Ala Met Gln Glu Ala 
        115                 120                 125             


Ser Glu Ala Val Pro Ser Gly Met Leu Ser Val Leu Gly Gln Pro Gln 
    130                 135                 140                 


Ser Lys Phe Asn Phe Ala Cys Leu Glu Ala Arg Glu His Cys Lys Ser 
145                 150                 155                 160 


Leu Gly Ile Glu Asn Pro Val Cys Glu Val Ser Asn Tyr Leu Phe Pro 
                165                 170                 175     


Asp Cys Arg Val Ile Ser Gly His Gln Glu Ala Leu Arg Phe Leu Gln 
            180                 185                 190         


Lys Asn Ser Ser Lys Phe His Phe Arg Arg Thr Arg Met Leu Pro Val 
        195                 200                 205             


Ser Gly Ala Phe His Thr Arg Leu Met Glu Pro Ala Val Glu Pro Leu 
    210                 215                 220                 


Thr Gln Ala Leu Lys Ala Val Asp Ile Lys Lys Pro Leu Val Ser Val 
225                 230                 235                 240 


Tyr Ser Asn Val His Gly His Arg Tyr Arg His Pro Gly His Ile His 
                245                 250                 255     


Lys Leu Leu Ala Gln Gln Leu Val Ser Pro Val Lys Trp Glu Gln Thr 
            260                 265                 270         


Met His Ala Ile Tyr Glu Arg Lys Lys Gly Arg Gly Phe Pro Gln Thr 
        275                 280                 285             


Phe Glu Val Gly Pro Gly Arg Gln Leu Gly Ala Ile Leu Lys Ser Cys 
    290                 295                 300                 


Asn Met Gln Ala Trp Lys Ser Tyr Ser Ala Val Asp Val Leu Gln Thr 
305                 310                 315                 320 


Leu Glu His Val Asp Leu Asp Pro Gln Glu Pro Pro Arg 
                325                 330             


<210>  808
<211>  989
<212>  DNA
<213>  Homo sapiens

<400>  808
gttgaaaaag agaacttggc aatagaaagt caatcgaaaa ctcagaaaaa agggaagata       60

tctcatgaca aaaggaagaa atcaagaagt aaagccatag gctcagatac ttctgacatt      120

gtgcacattt ggtgtccaga aggaatgaaa accagtgaca tcaaggagtt gaatattgtt      180

ttgcctgaat ttgagaaaac ccacctagag catcaacaaa gaatagaatc taaagtttgt      240

aaggcagcca tcgccacatt ttatgttaat gttaaagaac aattcatcaa aatgcttaaa      300

gaaagccaga tgttgacaaa tctgaaaagg aagaatgcta agatgatttc agatatcgaa      360

aagaaaaggc agcgtatgat tgaagtccag gatgaactgc ttcggttaga gccacagctg      420

aaacaactac aaacaaaata tgatgaactt aaagagagaa agtcttccct taggaatgca      480

gcatatttct tatctaattt aaaacagctt tatcaagatt attcagatgt tcaagctcaa      540

gaaccaaacg taaaggaaac gtatgattca tccagccttc cagctctgtt atttaaagca      600

agaacacttc tgggagccga aagccatctg cgaaatatca accatcagtt agagaagctc      660

cttgaccagg gatgagaaga gcagtctact aaaatgtgcc tataggaaga ctagtctcat      720

gctgttacct tctgaaactg tacctttata aatcaattgt tttgcaaaga agttatggcc      780

tacttagaat ctaaaatttg ttattcaaat taaatggctg tgaacaatgt taaatagcat      840

cagtttgtcc aatagtttta aaggccataa tcatcttttc tggttaatat cttgagtaat      900

tttaaaatgt tgacacctta atcggtccca ggtatgagct ataataaact tgtaaaatta      960

aaaaaaaaaa aaaaaaaaaa aaaaaaaaa                                        989


<210>  809
<211>  418
<212>  PRT
<213>  Homo sapiens

<400>  809

Met Ala Pro Arg Gly Arg Arg Arg Pro Arg Pro His Arg Ser Glu Gly 
1               5                   10                  15      


Ala Arg Arg Ser Lys Asn Thr Leu Glu Arg Thr His Ser Met Lys Asp 
            20                  25                  30          


Lys Ala Gly Gln Lys Cys Lys Pro Ile Asp Val Phe Asp Phe Pro Asp 
        35                  40                  45              


Asn Ser Asp Val Ser Ser Ile Gly Arg Leu Gly Glu Asn Glu Lys Asp 
    50                  55                  60                  


Glu Glu Thr Tyr Glu Thr Phe Asp Pro Pro Leu His Ser Thr Ala Ile 
65                  70                  75                  80  


Tyr Ala Asp Glu Glu Glu Phe Ser Lys His Cys Gly Leu Ser Leu Ser 
                85                  90                  95      


Ser Thr Pro Pro Gly Lys Glu Ala Lys Arg Ser Ser Asp Thr Ser Gly 
            100                 105                 110         


Asn Glu Ala Ser Glu Ile Glu Ser Val Lys Ile Ser Ala Lys Lys Pro 
        115                 120                 125             


Gly Arg Lys Leu Arg Pro Ile Ser Asp Asp Ser Glu Ser Ile Glu Glu 
    130                 135                 140                 


Ser Asp Thr Arg Arg Lys Val Lys Ser Ala Glu Lys Ile Ser Thr Gln 
145                 150                 155                 160 


Arg His Glu Val Ile Arg Thr Thr Ala Ser Ser Glu Leu Ser Glu Lys 
                165                 170                 175     


Pro Ala Glu Ser Val Thr Ser Lys Lys Thr Gly Pro Leu Ser Ala Gln 
            180                 185                 190         


Pro Ser Val Glu Lys Glu Asn Leu Ala Ile Glu Ser Gln Ser Lys Thr 
        195                 200                 205             


Gln Lys Lys Gly Lys Ile Ser His Asp Lys Arg Lys Lys Ser Arg Ser 
    210                 215                 220                 


Lys Ala Ile Gly Ser Asp Thr Ser Asp Ile Val His Ile Trp Cys Pro 
225                 230                 235                 240 


Glu Gly Met Lys Thr Ser Asp Ile Lys Glu Leu Asn Ile Val Leu Pro 
                245                 250                 255     


Glu Phe Glu Lys Thr His Leu Glu His Gln Gln Arg Ile Glu Ser Lys 
            260                 265                 270         


Val Cys Lys Ala Ala Ile Ala Thr Phe Tyr Val Asn Val Lys Glu Gln 
        275                 280                 285             


Phe Ile Lys Met Leu Lys Glu Ser Gln Met Leu Thr Asn Leu Lys Arg 
    290                 295                 300                 


Lys Asn Ala Lys Met Ile Ser Asp Ile Glu Lys Lys Arg Gln Arg Met 
305                 310                 315                 320 


Ile Glu Val Gln Asp Glu Leu Leu Arg Leu Glu Pro Gln Leu Lys Gln 
                325                 330                 335     


Leu Gln Thr Lys Tyr Asp Glu Leu Lys Glu Arg Lys Ser Ser Leu Arg 
            340                 345                 350         


Asn Ala Ala Tyr Phe Leu Ser Asn Leu Lys Gln Leu Tyr Gln Asp Tyr 
        355                 360                 365             


Ser Asp Val Gln Ala Gln Glu Pro Asn Val Lys Glu Thr Tyr Asp Ser 
    370                 375                 380                 


Ser Ser Leu Pro Ala Leu Leu Phe Lys Ala Arg Thr Leu Leu Gly Ala 
385                 390                 395                 400 


Glu Ser His Leu Arg Asn Ile Asn His Gln Leu Glu Lys Leu Leu Asp 
                405                 410                 415     


Gln Gly 
        


<210>  810
<211>  176
<212>  PRT
<213>  Homo sapiens

<400>  810

Met Lys Thr Ser Asp Ile Lys Glu Leu Asn Ile Val Leu Pro Glu Phe 
1               5                   10                  15      


Glu Lys Thr His Leu Glu His Gln Gln Arg Ile Glu Ser Lys Val Cys 
            20                  25                  30          


Lys Ala Ala Ile Ala Thr Phe Tyr Val Asn Val Lys Glu Gln Phe Ile 
        35                  40                  45              


Lys Met Leu Lys Glu Ser Gln Met Leu Thr Asn Leu Lys Arg Lys Asn 
    50                  55                  60                  


Ala Lys Met Ile Ser Asp Ile Glu Lys Lys Arg Gln Arg Met Ile Glu 
65                  70                  75                  80  


Val Gln Asp Glu Leu Leu Arg Leu Glu Pro Gln Leu Lys Gln Leu Gln 
                85                  90                  95      


Thr Lys Tyr Asp Glu Leu Lys Glu Arg Lys Ser Ser Leu Arg Asn Ala 
            100                 105                 110         


Ala Tyr Phe Leu Ser Asn Leu Lys Gln Leu Tyr Gln Asp Tyr Ser Asp 
        115                 120                 125             


Val Gln Ala Gln Glu Pro Asn Val Lys Glu Thr Tyr Asp Ser Ser Ser 
    130                 135                 140                 


Leu Pro Ala Leu Leu Phe Lys Ala Arg Thr Leu Leu Gly Ala Glu Ser 
145                 150                 155                 160 


His Leu Arg Asn Ile Asn His Gln Leu Glu Lys Leu Leu Asp Gln Gly 
                165                 170                 175     


<210>  811
<211>  803
<212>  DNA
<213>  Homo sapiens

<400>  811
ccaagctgta gctatgacgg cgcgcgggac tccgagccgc ttcttggcca gcgttctcca       60

caacggactg ggtcgctatg tgcagcagct gcagcgtctg agcttcagcg tcagccgcga      120

cggcgcctcg tctcgcggcg ccagggagtt cgtggagcgg gaggtgatcg acttcgcccg      180

acggaatcca ggggtcgtaa tatatgtaaa ctcgcgtccg tgctgcgtgc ccagagtagt      240

ggccgaatac cttaacgggg ctgtgcgcga ggagagcatc cactgcaagt cggtcgagga      300

gatctcgacg ctggtgcaga agctggccga ccagtcgggc ttggacgtga tccgcatccg      360

caagcccttc cacaccgaca accctagcat ccagggccag tggcacccct tcaccaacaa      420

gccgaccacg ttccgcgggc tacgcccccg agaggttcag gatcctgccc cagcccagtg      480

cctgcttctg ggggcagtga ccttgtgaac cactcatttt tatgcaagtg gcatccctaa      540

aacctgagat gaggaagact tcaagggttt tacagggccc ttgtttttta aatccaaatt      600

gataataatg atctcaaaac acagtgagag gtctgaaggc tggcttctga agaatccctg      660

atgtcttatt ggaacaacca ctgagctacg gagagctctg ctgtgatggg ctaggcactt      720

tatatctgtg tgaatacaga tttataaaac aggttaataa acttatccaa ggtcacattt      780

caaaaaaaaa aaaaaaaaaa aaa                                              803


<210>  812
<211>  215
<212>  PRT
<213>  Homo sapiens

<400>  812

Met Thr Ala Arg Gly Thr Pro Ser Arg Phe Leu Ala Ser Val Leu His 
1               5                   10                  15      


Asn Gly Leu Gly Arg Tyr Val Gln Gln Leu Gln Arg Leu Ser Phe Ser 
            20                  25                  30          


Val Ser Arg Asp Gly Ala Ser Ser Arg Gly Ala Arg Glu Phe Val Glu 
        35                  40                  45              


Arg Glu Val Ile Asp Phe Ala Arg Arg Asn Pro Gly Val Val Ile Tyr 
    50                  55                  60                  


Val Asn Ser Arg Pro Cys Cys Val Pro Arg Val Val Ala Glu Tyr Leu 
65                  70                  75                  80  


Asn Gly Ala Val Arg Glu Glu Ser Ile His Cys Lys Ser Val Glu Glu 
                85                  90                  95      


Ile Ser Thr Leu Val Gln Lys Leu Ala Asp Gln Ser Gly Leu Asp Val 
            100                 105                 110         


Ile Arg Ile Arg Lys Pro Phe His Thr Asp Asn Pro Ser Ile Gln Gly 
        115                 120                 125             


Gln Trp His Pro Phe Thr Asn Lys Pro Thr Thr Phe Arg Gly Leu Arg 
    130                 135                 140                 


Pro Arg Glu Val Gln Asp Pro Ala Pro Ala Gln Asp Thr Gly Leu Arg 
145                 150                 155                 160 


Leu Ser Ala Val Ala Pro Gln Ile Leu Leu Pro Gly Trp Pro Asp Pro 
                165                 170                 175     


Pro Asp Leu Pro Thr Val Asp Pro Ile Ser Ser Ser Leu Thr Ser Ala 
            180                 185                 190         


Pro Ala Pro Met Leu Ser Ala Val Ser Cys Leu Pro Ile Val Pro Ala 
        195                 200                 205             


Leu Thr Thr Val Cys Ser Ala 
    210                 215 


<210>  813
<211>  164
<212>  PRT
<213>  Homo sapiens

<400>  813

Met Thr Ala Arg Gly Thr Pro Ser Arg Phe Leu Ala Ser Val Leu His 
1               5                   10                  15      


Asn Gly Leu Gly Arg Tyr Val Gln Gln Leu Gln Arg Leu Ser Phe Ser 
            20                  25                  30          


Val Ser Arg Asp Gly Ala Ser Ser Arg Gly Ala Arg Glu Phe Val Glu 
        35                  40                  45              


Arg Glu Val Ile Asp Phe Ala Arg Arg Asn Pro Gly Val Val Ile Tyr 
    50                  55                  60                  


Val Asn Ser Arg Pro Cys Cys Val Pro Arg Val Val Ala Glu Tyr Leu 
65                  70                  75                  80  


Asn Gly Ala Val Arg Glu Glu Ser Ile His Cys Lys Ser Val Glu Glu 
                85                  90                  95      


Ile Ser Thr Leu Val Gln Lys Leu Ala Asp Gln Ser Gly Leu Asp Val 
            100                 105                 110         


Ile Arg Ile Arg Lys Pro Phe His Thr Asp Asn Pro Ser Ile Gln Gly 
        115                 120                 125             


Gln Trp His Pro Phe Thr Asn Lys Pro Thr Thr Phe Arg Gly Leu Arg 
    130                 135                 140                 


Pro Arg Glu Val Gln Asp Pro Ala Pro Ala Gln Cys Leu Leu Leu Gly 
145                 150                 155                 160 


Ala Val Thr Leu 
                


<210>  814
<211>  897
<212>  DNA
<213>  Homo sapiens

<400>  814
agtggaacct ggctctgggg agaagccgcg tgagatccgc gcgggtgcta gctagtcctt       60

tctcgtcgct gctcggctcg cggcccgtgg ggtcggcccc gccaccgttg ccgccatgcc      120

catgaagggc cgcttcccca tccgccgcac cctgcaatat ctgagccagg ggaacgtggt      180

gttcaaggac tccgtgaagg tcatgacagt gaattacaac acgcatgggg agctgggcga      240

gggcgccagg aagtttgtgt ttttcaacat acctcagatt caatacaaaa acccttgggt      300

gcagatcatg atgtttaaga acatgacgcc gtcacccttc ctgcgattct acttagattc      360

tggggagcag gtcctggtgg atgtggagac caagagcaat aaggagatca tggagcacat      420

cagaaaaatc ttggggaaga atgaggaaac cctcagggaa gaggaggagg agaaaaagca      480

gctttctcac ccagccaact tcggccctcg aaagtactgc ctgcgggagt gcatctgtga      540

agtggaaggg caggtgccct gccccagcct ggtgccatta cccaaggaga tgagggggaa      600

gtacaaagcc gctctgaaag ccgatgccca ggactaaggc ccacggtcac tgtgggctgg      660

ggtgatggtg tctgaccagt ggggagattg gaatgggatt actttggccc agggaagccc      720

ctggttctgt ccctggagac tctggaaatc cttttgcatt aaaaggactt tacacacctg      780

tgtaaaagga tgtgggagag gagggtctga agctgagctg ctaaatgaat atccctgctc      840

tgctggtcaa taaaacgctt cctaatagca aaaaaaaaaa aaaaaaaaaa aaaaaaa         897


<210>  815
<211>  173
<212>  PRT
<213>  Homo sapiens

<400>  815

Met Pro Met Lys Gly Arg Phe Pro Ile Arg Arg Thr Leu Gln Tyr Leu 
1               5                   10                  15      


Ser Gln Gly Asn Val Val Phe Lys Asp Ser Val Lys Val Met Thr Val 
            20                  25                  30          


Asn Tyr Asn Thr His Gly Glu Leu Gly Glu Gly Ala Arg Lys Phe Val 
        35                  40                  45              


Phe Phe Asn Ile Pro Gln Ile Gln Tyr Lys Asn Pro Trp Val Gln Ile 
    50                  55                  60                  


Met Met Phe Lys Asn Met Thr Pro Ser Pro Phe Leu Arg Phe Tyr Leu 
65                  70                  75                  80  


Asp Ser Gly Glu Gln Val Leu Val Asp Val Glu Thr Lys Ser Asn Lys 
                85                  90                  95      


Glu Ile Met Glu His Ile Arg Lys Ile Leu Gly Lys Asn Glu Glu Thr 
            100                 105                 110         


Leu Arg Glu Glu Glu Glu Glu Lys Lys Gln Leu Ser His Pro Ala Asn 
        115                 120                 125             


Phe Gly Pro Arg Lys Tyr Cys Leu Arg Glu Cys Ile Cys Glu Val Glu 
    130                 135                 140                 


Gly Gln Val Pro Cys Pro Ser Leu Val Pro Leu Pro Lys Glu Met Arg 
145                 150                 155                 160 


Gly Lys Tyr Lys Ala Ala Leu Lys Ala Asp Ala Gln Asp 
                165                 170             


<210>  816
<211>  173
<212>  PRT
<213>  Homo sapiens

<400>  816

Met Pro Met Lys Gly Arg Phe Pro Ile Arg Arg Thr Leu Gln Tyr Leu 
1               5                   10                  15      


Ser Gln Gly Asn Val Val Phe Lys Asp Ser Val Lys Val Met Thr Val 
            20                  25                  30          


Asn Tyr Asn Thr His Gly Glu Leu Gly Glu Gly Ala Arg Lys Phe Val 
        35                  40                  45              


Phe Phe Asn Ile Pro Gln Ile Gln Tyr Lys Asn Pro Trp Val Gln Ile 
    50                  55                  60                  


Met Met Phe Lys Asn Met Thr Pro Ser Pro Phe Leu Arg Phe Tyr Leu 
65                  70                  75                  80  


Asp Ser Gly Glu Gln Val Leu Val Asp Val Glu Thr Lys Ser Asn Lys 
                85                  90                  95      


Glu Ile Met Glu His Ile Arg Lys Ile Leu Gly Lys Asn Glu Glu Thr 
            100                 105                 110         


Leu Arg Glu Glu Glu Glu Glu Lys Lys Gln Leu Ser His Pro Ala Asn 
        115                 120                 125             


Phe Gly Pro Arg Lys Tyr Cys Leu Arg Glu Cys Ile Cys Glu Val Glu 
    130                 135                 140                 


Gly Gln Val Pro Cys Pro Ser Leu Val Pro Leu Pro Lys Glu Met Arg 
145                 150                 155                 160 


Gly Lys Tyr Lys Ala Ala Leu Lys Ala Asp Ala Gln Asp 
                165                 170             


<210>  817
<211>  6099
<212>  DNA
<213>  Homo sapiens

<400>  817
ccggcggccg agcgttctga gtcacccggg actggaggta ggaacccagc catggtgaac       60

gaagccagag gaaacagcag cctcaacccc tgcttggagg gcagtgccag cagtggcagt      120

gagagctcca aagatagttc gagatgttcc accccgggcc tggaccctga gcggcatgag      180

agactccggg agaagatgag gcggcgattg gaatctggtg acaagtggtt ctccctggaa      240

ttcttccctc ctcgaactgc tgagggagct gtcaatctca tctcaaggtt tgaccggatg      300

gcagcaggtg gccccctcta catagacgtg acctggcacc cagcaggtga ccctggctca      360

gacaaggaga cctcctccat gatgatcgcc agcaccgccg tgaactactg tggcctggag      420

accatcctgc acatgacctg ctgccgtcag cgcctggagg agatcacggg ccatctgcac      480

aaagctaagc agctgggcct gaagaacatc atggcgctgc ggggagaccc aataggtgac      540

cagtgggaag aggaggaggg aggcttcaac tacgcagtgg acctggtgaa gcacatccga      600

agtgagtttg gtgactactt tgacatctgt gtggcaggtt accccaaagg ccaccccgaa      660

gcagggagct ttgaggctga cctgaagcac ttgaaggaga aggtgtctgc gggagccgat      720

ttcatcatca cgcagctttt ctttgaggct gacacattct tccgctttgt gaaggcatgc      780

accgacatgg gcatcacttg ccccatcgtc cccgggatct ttcccatcca gggctaccac      840

tcccttcggc agcttgtgaa gctgtccaag ctggaggtgc cacaggagat caaggacgtg      900

attgagccaa tcaaagacaa cgatgctgcc atccgcaact atggcatcga gctggccgtg      960

agcctgtgcc aggagcttct ggccagtggc ttggtgccag gcctccactt ctacaccctc     1020

aaccgcgaga tggctaccac agaggtgctg aagcgcctgg ggatgtggac tgaggacccc     1080

aggcgtcccc taccctgggc tctcagtgcc caccccaagc gccgagagga agatgtacgt     1140

cccatcttct gggcctccag accaaagagt tacatctacc gtacccagga gtgggacgag     1200

ttccctaacg gccgctgggg caattcctct tcccctgcct ttggggagct gaaggactac     1260

tacctcttct acctgaagag caagtccccc aaggaggagc tgctgaagat gtggggggag     1320

gagctgacca gtgaagcaag tgtctttgaa gtctttgttc tttacctctc gggagaacca     1380

aaccggaatg gtcacaaagt gacttgcctg ccctggaacg atgagcccct ggcggctgag     1440

accagcctgc tgaaggagga gctgctgcgg gtgaaccgcc agggcatcct caccatcaac     1500

tcacagccca acatcaacgg gaagccgtcc tccgacccca tcgtgggctg gggccccagc     1560

gggggctatg tcttccagaa ggcctactta gagtttttca cttcccgcga gacagcggaa     1620

gcacttctgc aagtgctgaa gaagtacgag ctccgggtta attaccacct tgtcaatgtg     1680

aagggtgaaa acatcaccaa tgcccctgaa ctgcagccga atgctgtcac ttggggcatc     1740

ttccctgggc gagagatcat ccagcccacc gtagtggatc ccgtcagctt catgttctgg     1800

aaggacgagg cctttgccct gtggattgag cagtggggaa agctgtatga ggaggagtcc     1860

ccgtcccgca ccatcatcca gtacatccac gacaactact tcctggtcaa cctggtggac     1920

aatgacttcc cactggacaa ctgcctctgg caggtggtgg aagacacatt ggagcttctc     1980

aacaggccca cccagaatgc gagagaaacg gaggctccat gaccctgcgt cctgacgccc     2040

tgcgttggag ccactcctgt cccgccttcc tcctccacag tgctgcttct cttgggaact     2100

ccactctcct tcgtgtctct cccaccccgg cctccactcc cccacctgac aatggcagct     2160

agactggagt gaggcttcca ggctcttcct ggacctgagt cggccccaca tgggaaccta     2220

gtactctctg ctctagccag gagtctgtgc tcttttggtg gggagcactt gcgtcctgca     2280

gaggaccaca gtgggtggca cctcctgaga aggcgaggag agtggttgtt gccaactaag     2340

ccctcgaacc aaggcagcct ccagagccag cctgggactc ccagtgaact tacacttgga     2400

gcccgtgcag tacaggcaaa acacgcaagg gcatcaggca ctggtggcat cgtagaagag     2460

atgtggcaaa gtgctgtacc cttccacctc ctagaggtgg gcagctgggc cccacctact     2520

tgtgactgaa ggggcacacc actgccctgc ctgcccactt agccgtccat ggcaccagcc     2580

ccctggatgg gcattgggct gacacctacc atgctgcttt ttggcacagt tgtctattct     2640

gagccttgag agaaaaagtg ccccttaagg gttgaaggca gtctgaaccc ttgtgcttgg     2700

tggggctcgt ggccttcccc ttttgcctgg ctgtggaggc ctgatgctgc cccgttccct     2760

gtcagaggct aagatgagat ttgccagcac aggggcccca gatctgcctg ggcctgtgca     2820

gcagcccagc ttcctggtgt atttttcagg taggcccttg tcctgccagc tgccttcctc     2880

atcccctcgt cctgtcccag aggttatctg cctggcctgg ctccccacga gtcacctgca     2940

agccccaggg cctgggggca gtgactggca ggtgcagatg ggctgtttcg tgtagtggaa     3000

gagcagcctg atggccaagg gggtggacgc aattgtggga tgtcctcttt actcccttcc     3060

tggcctcact ggctggggca gaggggcagc cgctaggaga gactgaaagc agcagctagg     3120

actgaggagt gggttttatt gtccttcaga gctcttcaag ctgtcccctc tgtcatcact     3180

ccctggatgt gtggggcatg gttccttccc tgggaaggct aagttcagtt ctgtttttta     3240

ttctatgaga acaagtcaca gctgcagctg ggccccatgc tctgccccaa gcccccaacc     3300

ccgcggtgct ccggcggctt cctgtccact ctcggggccc ttggggcctg gcttgctcca     3360

gggtcttggg ctactggcag ctcctctcct tgggctcctg gctgccaggc gttggtgcca     3420

cttcttaaag gcctggaacc agggaggaga ggaaatgcta ttgttgtggg ctttctccgg     3480

ggtctgtgct gtgcctgcta gagcaacccc tgtacccagc tccttttgtc cccagggccc     3540

ctccctctgc cccaagcagc cagccagtct tgcctaggcc aaatgcacaa gctcagaata     3600

gatctgatgg tgagctggga agctgtactc agagcagagc aaatgaggga gggggcgctc     3660

aggacccagg ccctccatgg gctagtgtga gtggcagcca tgcctcatgc cacaccttct     3720

tcgcaaactg atggaccggg tgggcctggc ctgagctggg gccacaaatc aaagcaaggg     3780

ctccagtatc cagcctgtgt gttctgtaat ggaactgacc ccctcccctg aaaacgaagg     3840

ggccccgggg ctggcaagca gggaaagctc cacggtgcgc ggctgtggca cagacttctg     3900

gaaggctggc tgagtggaat gcagggaaga gggcagtacc tgggaaagga cccacccatc     3960

ttcctgctgc tgtaactgct gagccactcg cagtcgcagg atccgctgcc accacgtctg     4020

ccaggcccat ctcaggtgcc actccctgag ctttggggac agttggcaga gaaggcctct     4080

tgtgctcacg ctcccccgca gtccccagcc cttctgcctt tctcccccga cactgctgca     4140

ccagagtgaa agggctatgg caagggggtg tcatctgagg agtattaaga atgcagattc     4200

ctgggcctgt cccccaaggt tttggagtca gtaggtccaa gggccatact tttgagaggg     4260

gtttgggtta agtatgaggt gaaatgggag atggtcagtg tggagagggg tgcacccact     4320

caccagggtc cgcaccagct gctctgcccc ttgggcatcc acccagtgct gccatgccac     4380

tgccaggcac ctggcctgct gggaaccccg cagcccgtga agcagtgcct cgaggcaccg     4440

gcgctgcagg tacttcctcc tgatggccaa gagcatcgtg acccttcagg gccagaagga     4500

gggcagagcc atgggcctgg gcctgctttt ccaggatcct gcaggaacga gcactggcca     4560

gagagggccc agctgtagcc atggctcagg caagcccctc agcccttgcc cccatccctc     4620

ggacccacca aactgcacac acagctcctc ttaccgtagc ctccgtttat gggccttgct     4680

ttgggctttg gaggctctgg gctcagggct ggagtgcgct cttggtccct ggtccctcgt     4740

ccacaggggc aggcctggga cccagctact ctgtccaggc cactgtggcc agagctggaa     4800

ggcagggcag agggaatgtt ccctgcaccc tggaaagggg agttgagtca caagagttta     4860

aggtgggtcc aggaaggcag ctgctcttag tgcccgctta ggagttgagt acagtgagga     4920

gggtggagga aggtgctgag cttagccttg tgccctgccc ccatctcccc aggcctccag     4980

cctctcacgg ctgcctgccg cccaaagaga aatcacaggg gcggggcagg aatgcaaagt     5040

gttttctcag aacagctgaa acattccgaa gagggaatgg atggggagaa tggtcaatac     5100

acataagacc gtgtcccaag gagctgattt ccaggcccct gaggactgga gaccgcttca     5160

cccctgcact tcagacaccg tttgtccccc ggggcaaggt ctccttactc tgagcccagg     5220

ccgttcccct tggcttcctc cgtccaccca ggctgcactg cagtgatggc gcgggaggca     5280

ccagctctgt ggcctgtgtc cagcagctgt gggtctgaag gaatagccag agaggagcac     5340

ctgaacccca tgggcttgga cttcctgggg ccccgctggg atttcttcgc tgctctagct     5400

ggcaggacac atcccggcct cttccaccca ttcccccatg tggctgaaga cattccaaca     5460

atggggtggg cccataatag ttagccctca gtcagttccc ggagcacagc cctgggaggg     5520

ggctatttct ctccccactg aaaacatttc aaagctgagt tacttgtctg aggcctcatc     5580

cctcggaagc cgtctgactc cagagtctga gcccccggct agtaccctat agagaggggg     5640

ctctccaaag gggctgctgg ggcatgtgtg cctgtggcag aaaagaggag accctggaat     5700

tcagcaccct gggtgccatt cccagcgttt agtttctaga ggcctcagtt tctccatcag     5760

cttatgggat ccttgtcttt actgacaaga atggaataga aatgtaaaag tactctgaaa     5820

agcaattgcc ctgtaactta tctagaaaga aaagaccctg agactccaga atctgctgtt     5880

gccatagccc catatgtgtg aattctgcaa ctagccaagg ctagttcctt tcaattccat     5940

ttaaaaaaca aaaaccagca ggtgtggtgg ctcatggcgt aatgggcctg cccaatgctt     6000

tgggaggcca aggcagatag atcgcttgag cccaggagtt tgagacaagc cctggcaaca     6060

tagtgagatc ccatttctac aaaaaaaaaa aaaaaaaaa                            6099


<210>  818
<211>  656
<212>  PRT
<213>  Homo sapiens

<400>  818

Met Val Asn Glu Ala Arg Gly Asn Ser Ser Leu Asn Pro Cys Leu Glu 
1               5                   10                  15      


Gly Ser Ala Ser Ser Gly Ser Glu Ser Ser Lys Asp Ser Ser Arg Cys 
            20                  25                  30          


Ser Thr Pro Gly Leu Asp Pro Glu Arg His Glu Arg Leu Arg Glu Lys 
        35                  40                  45              


Met Arg Arg Arg Leu Glu Ser Gly Asp Lys Trp Phe Ser Leu Glu Phe 
    50                  55                  60                  


Phe Pro Pro Arg Thr Ala Glu Gly Ala Val Asn Leu Ile Ser Arg Phe 
65                  70                  75                  80  


Asp Arg Met Ala Ala Gly Gly Pro Leu Tyr Ile Asp Val Thr Trp His 
                85                  90                  95      


Pro Ala Gly Asp Pro Gly Ser Asp Lys Glu Thr Ser Ser Met Met Ile 
            100                 105                 110         


Ala Ser Thr Ala Val Asn Tyr Cys Gly Leu Glu Thr Ile Leu His Met 
        115                 120                 125             


Thr Cys Cys Arg Gln Arg Leu Glu Glu Ile Thr Gly His Leu His Lys 
    130                 135                 140                 


Ala Lys Gln Leu Gly Leu Lys Asn Ile Met Ala Leu Arg Gly Asp Pro 
145                 150                 155                 160 


Ile Gly Asp Gln Trp Glu Glu Glu Glu Gly Gly Phe Asn Tyr Ala Val 
                165                 170                 175     


Asp Leu Val Lys His Ile Arg Ser Glu Phe Gly Asp Tyr Phe Asp Ile 
            180                 185                 190         


Cys Val Ala Gly Tyr Pro Lys Gly His Pro Glu Ala Gly Ser Phe Glu 
        195                 200                 205             


Ala Asp Leu Lys His Leu Lys Glu Lys Val Ser Ala Gly Ala Asp Phe 
    210                 215                 220                 


Ile Ile Thr Gln Leu Phe Phe Glu Ala Asp Thr Phe Phe Arg Phe Val 
225                 230                 235                 240 


Lys Ala Cys Thr Asp Met Gly Ile Thr Cys Pro Ile Val Pro Gly Ile 
                245                 250                 255     


Phe Pro Ile Gln Gly Tyr His Ser Leu Arg Gln Leu Val Lys Leu Ser 
            260                 265                 270         


Lys Leu Glu Val Pro Gln Glu Ile Lys Asp Val Ile Glu Pro Ile Lys 
        275                 280                 285             


Asp Asn Asp Ala Ala Ile Arg Asn Tyr Gly Ile Glu Leu Ala Val Ser 
    290                 295                 300                 


Leu Cys Gln Glu Leu Leu Ala Ser Gly Leu Val Pro Gly Leu His Phe 
305                 310                 315                 320 


Tyr Thr Leu Asn Arg Glu Met Ala Thr Thr Glu Val Leu Lys Arg Leu 
                325                 330                 335     


Gly Met Trp Thr Glu Asp Pro Arg Arg Pro Leu Pro Trp Ala Leu Ser 
            340                 345                 350         


Ala His Pro Lys Arg Arg Glu Glu Asp Val Arg Pro Ile Phe Trp Ala 
        355                 360                 365             


Ser Arg Pro Lys Ser Tyr Ile Tyr Arg Thr Gln Glu Trp Asp Glu Phe 
    370                 375                 380                 


Pro Asn Gly Arg Trp Gly Asn Ser Ser Ser Pro Ala Phe Gly Glu Leu 
385                 390                 395                 400 


Lys Asp Tyr Tyr Leu Phe Tyr Leu Lys Ser Lys Ser Pro Lys Glu Glu 
                405                 410                 415     


Leu Leu Lys Met Trp Gly Glu Glu Leu Thr Ser Glu Glu Ser Val Phe 
            420                 425                 430         


Glu Val Phe Val Leu Tyr Leu Ser Gly Glu Pro Asn Arg Asn Gly His 
        435                 440                 445             


Lys Val Thr Cys Leu Pro Trp Asn Asp Glu Pro Leu Ala Ala Glu Thr 
    450                 455                 460                 


Ser Leu Leu Lys Glu Glu Leu Leu Arg Val Asn Arg Gln Gly Ile Leu 
465                 470                 475                 480 


Thr Ile Asn Ser Gln Pro Asn Ile Asn Gly Lys Pro Ser Ser Asp Pro 
                485                 490                 495     


Ile Val Gly Trp Gly Pro Ser Gly Gly Tyr Val Phe Gln Lys Ala Tyr 
            500                 505                 510         


Leu Glu Phe Phe Thr Ser Arg Glu Thr Ala Glu Ala Leu Leu Gln Val 
        515                 520                 525             


Leu Lys Lys Tyr Glu Leu Arg Val Asn Tyr His Leu Val Asn Val Lys 
    530                 535                 540                 


Gly Glu Asn Ile Thr Asn Ala Pro Glu Leu Gln Pro Asn Ala Val Thr 
545                 550                 555                 560 


Trp Gly Ile Phe Pro Gly Arg Glu Ile Ile Gln Pro Thr Val Val Asp 
                565                 570                 575     


Pro Val Ser Phe Met Phe Trp Lys Asp Glu Ala Phe Ala Leu Trp Ile 
            580                 585                 590         


Glu Arg Trp Gly Lys Leu Tyr Glu Glu Glu Ser Pro Ser Arg Thr Ile 
        595                 600                 605             


Ile Gln Tyr Ile His Asp Asn Tyr Phe Leu Val Asn Leu Val Asp Asn 
    610                 615                 620                 


Asp Phe Pro Leu Asp Asn Cys Leu Trp Gln Val Val Glu Asp Thr Leu 
625                 630                 635                 640 


Glu Leu Leu Asn Arg Pro Thr Gln Asn Ala Arg Glu Thr Glu Ala Pro 
                645                 650                 655     


<210>  819
<211>  656
<212>  PRT
<213>  Homo sapiens

<400>  819

Met Val Asn Glu Ala Arg Gly Asn Ser Ser Leu Asn Pro Cys Leu Glu 
1               5                   10                  15      


Gly Ser Ala Ser Ser Gly Ser Glu Ser Ser Lys Asp Ser Ser Arg Cys 
            20                  25                  30          


Ser Thr Pro Gly Leu Asp Pro Glu Arg His Glu Arg Leu Arg Glu Lys 
        35                  40                  45              


Met Arg Arg Arg Leu Glu Ser Gly Asp Lys Trp Phe Ser Leu Glu Phe 
    50                  55                  60                  


Phe Pro Pro Arg Thr Ala Glu Gly Ala Val Asn Leu Ile Ser Arg Phe 
65                  70                  75                  80  


Asp Arg Met Ala Ala Gly Gly Pro Leu Tyr Ile Asp Val Thr Trp His 
                85                  90                  95      


Pro Ala Gly Asp Pro Gly Ser Asp Lys Glu Thr Ser Ser Met Met Ile 
            100                 105                 110         


Ala Ser Thr Ala Val Asn Tyr Cys Gly Leu Glu Thr Ile Leu His Met 
        115                 120                 125             


Thr Cys Cys Arg Gln Arg Leu Glu Glu Ile Thr Gly His Leu His Lys 
    130                 135                 140                 


Ala Lys Gln Leu Gly Leu Lys Asn Ile Met Ala Leu Arg Gly Asp Pro 
145                 150                 155                 160 


Ile Gly Asp Gln Trp Glu Glu Glu Glu Gly Gly Phe Asn Tyr Ala Val 
                165                 170                 175     


Asp Leu Val Lys His Ile Arg Ser Glu Phe Gly Asp Tyr Phe Asp Ile 
            180                 185                 190         


Cys Val Ala Gly Tyr Pro Lys Gly His Pro Glu Ala Gly Ser Phe Glu 
        195                 200                 205             


Ala Asp Leu Lys His Leu Lys Glu Lys Val Ser Ala Gly Ala Asp Phe 
    210                 215                 220                 


Ile Ile Thr Gln Leu Phe Phe Glu Ala Asp Thr Phe Phe Arg Phe Val 
225                 230                 235                 240 


Lys Ala Cys Thr Asp Met Gly Ile Thr Cys Pro Ile Val Pro Gly Ile 
                245                 250                 255     


Phe Pro Ile Gln Gly Tyr His Ser Leu Arg Gln Leu Val Lys Leu Ser 
            260                 265                 270         


Lys Leu Glu Val Pro Gln Glu Ile Lys Asp Val Ile Glu Pro Ile Lys 
        275                 280                 285             


Asp Asn Asp Ala Ala Ile Arg Asn Tyr Gly Ile Glu Leu Ala Val Ser 
    290                 295                 300                 


Leu Cys Gln Glu Leu Leu Ala Ser Gly Leu Val Pro Gly Leu His Phe 
305                 310                 315                 320 


Tyr Thr Leu Asn Arg Glu Met Ala Thr Thr Glu Val Leu Lys Arg Leu 
                325                 330                 335     


Gly Met Trp Thr Glu Asp Pro Arg Arg Pro Leu Pro Trp Ala Leu Ser 
            340                 345                 350         


Ala His Pro Lys Arg Arg Glu Glu Asp Val Arg Pro Ile Phe Trp Ala 
        355                 360                 365             


Ser Arg Pro Lys Ser Tyr Ile Tyr Arg Thr Gln Glu Trp Asp Glu Phe 
    370                 375                 380                 


Pro Asn Gly Arg Trp Gly Asn Ser Ser Ser Pro Ala Phe Gly Glu Leu 
385                 390                 395                 400 


Lys Asp Tyr Tyr Leu Phe Tyr Leu Lys Ser Lys Ser Pro Lys Glu Glu 
                405                 410                 415     


Leu Leu Lys Met Trp Gly Glu Glu Leu Thr Ser Glu Ala Ser Val Phe 
            420                 425                 430         


Glu Val Phe Val Leu Tyr Leu Ser Gly Glu Pro Asn Arg Asn Gly His 
        435                 440                 445             


Lys Val Thr Cys Leu Pro Trp Asn Asp Glu Pro Leu Ala Ala Glu Thr 
    450                 455                 460                 


Ser Leu Leu Lys Glu Glu Leu Leu Arg Val Asn Arg Gln Gly Ile Leu 
465                 470                 475                 480 


Thr Ile Asn Ser Gln Pro Asn Ile Asn Gly Lys Pro Ser Ser Asp Pro 
                485                 490                 495     


Ile Val Gly Trp Gly Pro Ser Gly Gly Tyr Val Phe Gln Lys Ala Tyr 
            500                 505                 510         


Leu Glu Phe Phe Thr Ser Arg Glu Thr Ala Glu Ala Leu Leu Gln Val 
        515                 520                 525             


Leu Lys Lys Tyr Glu Leu Arg Val Asn Tyr His Leu Val Asn Val Lys 
    530                 535                 540                 


Gly Glu Asn Ile Thr Asn Ala Pro Glu Leu Gln Pro Asn Ala Val Thr 
545                 550                 555                 560 


Trp Gly Ile Phe Pro Gly Arg Glu Ile Ile Gln Pro Thr Val Val Asp 
                565                 570                 575     


Pro Val Ser Phe Met Phe Trp Lys Asp Glu Ala Phe Ala Leu Trp Ile 
            580                 585                 590         


Glu Gln Trp Gly Lys Leu Tyr Glu Glu Glu Ser Pro Ser Arg Thr Ile 
        595                 600                 605             


Ile Gln Tyr Ile His Asp Asn Tyr Phe Leu Val Asn Leu Val Asp Asn 
    610                 615                 620                 


Asp Phe Pro Leu Asp Asn Cys Leu Trp Gln Val Val Glu Asp Thr Leu 
625                 630                 635                 640 


Glu Leu Leu Asn Arg Pro Thr Gln Asn Ala Arg Glu Thr Glu Ala Pro 
                645                 650                 655     


<210>  820
<211>  1181
<212>  DNA
<213>  Homo sapiens

<400>  820
ggggactccc tcactggctg ccattgaaag agtccacttc tcagtgactc ctagctgggc       60

actggatgca gttgaggatt gctggtcaat atgattcttc ttgctgtgct ttttctctgc      120

ttcatttcct catattcagc ttctgttaaa ggtcacacaa ctggtctctc attaaataat      180

gaccggctgt acaagctcac gtactccact gaagttcttc ttgatcgggg caaaggaaaa      240

ctgcaagaca gcgtgggcta ccgcatttcc tccaacgtgg atgtggcctt actatggagg      300

aatcctgatg gtgatgatga ccagttgatc caaataacga tgaaggatgt aaatgttgaa      360

aatgtgaatc agcagagagg agagaagagc atcttcaaag gaaaaagccc atctaaaata      420

atgggaaagg aaaacttgga agctctgcaa agacctacgc tccttcatct aatccatgga      480

aaggtaaagg ggcgtttaga ttccacaact ttttctccaa cttcatattt ttcttccctt      540

cagtagatat tattttgagg taatcacatt gtaactactt ttatggtaaa tggaatttct      600

tcaagaacta aagaacagag gttgtaaatt aaatgtttcc aaactgaatc aatgccctga      660

gttcccttac atttactagc caatttgttt cctatttttc tggaaatctt tatagtggaa      720

tgaagtattt atttattgat gaaaggcatt attaaaaggt aaatttctca tcaaattata      780

agggattaca aacataatgt aacaaagcaa gtcatcaaag catgattgga tgaattcagg      840

aaaggagaca aattatgaga ctgaaatgat ccaactgaga ttagtaatat tgatttgtta      900

tgagattatc gatatctggc taaagtacaa ggttaaagat tttaaaaggg tatgacaagt      960

ctaaagtaga gtttttttaa agcctttaga aattatttta aaactatgac atggaaaagc     1020

cttttatata ttaaaataat gattgaacac tttataatat atatttgaaa atctgtttta     1080

aaaattctat gtgtgcatta cttatggctt gattctagtc aattgaaatg gtctaaataa     1140

atttggaatt gaaaaaaaaa aaaaaaaaaa aaaaaaaaaa a                         1181


<210>  821
<211>  894
<212>  PRT
<213>  Homo sapiens

<400>  821

Met Ile Leu Leu Ala Val Leu Phe Leu Cys Phe Ile Ser Ser Tyr Ser 
1               5                   10                  15      


Ala Ser Val Lys Gly His Thr Thr Gly Leu Ser Leu Asn Asn Asp Arg 
            20                  25                  30          


Leu Tyr Lys Leu Thr Tyr Ser Thr Glu Val Leu Leu Asp Arg Gly Lys 
        35                  40                  45              


Gly Lys Leu Gln Asp Ser Val Gly Tyr Arg Ile Ser Ser Asn Val Asp 
    50                  55                  60                  


Val Ala Leu Leu Trp Arg Asn Pro Asp Gly Asp Asp Asp Gln Leu Ile 
65                  70                  75                  80  


Gln Ile Thr Met Lys Asp Val Asn Val Glu Asn Val Asn Gln Gln Arg 
                85                  90                  95      


Gly Glu Lys Ser Ile Phe Lys Gly Lys Ser Pro Ser Lys Ile Met Gly 
            100                 105                 110         


Lys Glu Asn Leu Glu Ala Leu Gln Arg Pro Thr Leu Leu His Leu Ile 
        115                 120                 125             


His Gly Lys Val Lys Glu Phe Tyr Ser Tyr Gln Asn Glu Ala Val Ala 
    130                 135                 140                 


Ile Glu Asn Ile Lys Arg Gly Leu Ala Ser Leu Phe Gln Thr Gln Leu 
145                 150                 155                 160 


Ser Ser Gly Thr Thr Asn Glu Val Asp Ile Ser Gly Asn Cys Lys Val 
                165                 170                 175     


Thr Tyr Gln Ala His Gln Asp Lys Val Ile Lys Ile Lys Ala Leu Asp 
            180                 185                 190         


Ser Cys Lys Ile Ala Arg Ser Gly Phe Thr Thr Pro Asn Gln Val Leu 
        195                 200                 205             


Gly Val Ser Ser Lys Ala Thr Ser Val Thr Thr Tyr Lys Ile Glu Asp 
    210                 215                 220                 


Ser Phe Val Ile Ala Val Leu Ala Glu Glu Thr His Asn Phe Gly Leu 
225                 230                 235                 240 


Asn Phe Leu Gln Thr Ile Lys Gly Lys Ile Val Ser Lys Gln Lys Leu 
                245                 250                 255     


Glu Leu Lys Thr Thr Glu Ala Gly Pro Arg Leu Met Ser Gly Lys Gln 
            260                 265                 270         


Ala Ala Ala Ile Ile Lys Ala Val Asp Ser Lys Tyr Thr Ala Ile Pro 
        275                 280                 285             


Ile Val Gly Gln Val Phe Gln Ser His Cys Lys Gly Cys Pro Ser Leu 
    290                 295                 300                 


Ser Glu Leu Trp Arg Ser Thr Arg Lys Tyr Leu Gln Pro Asp Asn Leu 
305                 310                 315                 320 


Ser Lys Ala Glu Ala Val Arg Asn Phe Leu Ala Phe Ile Gln His Leu 
                325                 330                 335     


Arg Thr Ala Lys Lys Glu Glu Ile Leu Gln Ile Leu Lys Met Glu Asn 
            340                 345                 350         


Lys Glu Val Leu Pro Gln Leu Val Asp Ala Val Thr Ser Ala Gln Thr 
        355                 360                 365             


Ser Asp Ser Leu Glu Ala Ile Leu Asp Phe Leu Asp Phe Lys Ser Asp 
    370                 375                 380                 


Ser Ser Ile Ile Leu Gln Glu Arg Phe Leu Tyr Ala Cys Gly Phe Ala 
385                 390                 395                 400 


Ser His Pro Asn Glu Glu Leu Leu Arg Ala Leu Ile Ser Lys Phe Lys 
                405                 410                 415     


Gly Ser Ile Gly Ser Ser Asp Ile Arg Glu Thr Val Met Ile Ile Thr 
            420                 425                 430         


Gly Thr Leu Val Arg Lys Leu Cys Gln Asn Glu Gly Cys Lys Leu Lys 
        435                 440                 445             


Ala Val Val Glu Ala Lys Lys Leu Ile Leu Gly Gly Leu Glu Lys Ala 
    450                 455                 460                 


Glu Lys Lys Glu Asp Thr Arg Met Tyr Leu Leu Ala Leu Lys Asn Ala 
465                 470                 475                 480 


Leu Leu Pro Glu Gly Ile Pro Ser Leu Leu Lys Tyr Ala Glu Ala Gly 
                485                 490                 495     


Glu Gly Pro Ile Ser His Leu Ala Thr Thr Ala Leu Gln Arg Tyr Asp 
            500                 505                 510         


Leu Pro Phe Ile Thr Asp Glu Val Lys Lys Thr Leu Asn Arg Ile Tyr 
        515                 520                 525             


His Gln Asn Arg Lys Val His Glu Lys Thr Val Arg Thr Ala Ala Ala 
    530                 535                 540                 


Ala Ile Ile Leu Asn Asn Asn Pro Ser Tyr Met Asp Val Lys Asn Ile 
545                 550                 555                 560 


Leu Leu Ser Ile Gly Glu Leu Pro Gln Glu Met Asn Lys Tyr Met Leu 
                565                 570                 575     


Ala Ile Val Gln Asp Ile Leu Arg Phe Glu Met Pro Ala Ser Lys Ile 
            580                 585                 590         


Val Arg Arg Val Leu Lys Glu Met Val Ala His Asn Tyr Asp Arg Phe 
        595                 600                 605             


Ser Arg Ser Gly Ser Ser Ser Ala Tyr Thr Gly Tyr Ile Glu Arg Ser 
    610                 615                 620                 


Pro Arg Ser Ala Ser Thr Tyr Ser Leu Asp Ile Leu Tyr Ser Gly Ser 
625                 630                 635                 640 


Gly Ile Leu Arg Arg Ser Asn Leu Asn Ile Phe Gln Tyr Ile Gly Lys 
                645                 650                 655     


Ala Gly Leu His Gly Ser Gln Val Val Ile Glu Ala Gln Gly Leu Glu 
            660                 665                 670         


Ala Leu Ile Ala Ala Thr Pro Asp Glu Gly Glu Glu Asn Leu Asp Ser 
        675                 680                 685             


Tyr Ala Gly Met Ser Ala Ile Leu Phe Asp Val Gln Leu Arg Pro Val 
    690                 695                 700                 


Thr Phe Phe Asn Gly Tyr Ser Asp Leu Met Ser Lys Met Leu Ser Ala 
705                 710                 715                 720 


Ser Gly Asp Pro Ile Ser Val Val Lys Gly Leu Ile Leu Leu Ile Asp 
                725                 730                 735     


His Ser Gln Glu Leu Gln Leu Gln Ser Gly Leu Lys Ala Asn Ile Glu 
            740                 745                 750         


Val Gln Gly Gly Leu Ala Ile Asp Ile Ser Gly Ala Met Glu Phe Ser 
        755                 760                 765             


Leu Trp Tyr Arg Glu Ser Lys Thr Arg Val Lys Asn Arg Val Thr Val 
    770                 775                 780                 


Val Ile Thr Thr Asp Ile Thr Val Asp Ser Ser Phe Val Lys Ala Gly 
785                 790                 795                 800 


Leu Glu Thr Ser Thr Glu Thr Glu Ala Gly Leu Glu Phe Ile Ser Thr 
                805                 810                 815     


Val Gln Phe Ser Gln Tyr Pro Phe Leu Val Cys Met Gln Met Asp Lys 
            820                 825                 830         


Asp Glu Ala Pro Phe Arg Gln Phe Glu Lys Lys Tyr Glu Arg Leu Ser 
        835                 840                 845             


Thr Gly Arg Gly Tyr Val Ser Gln Lys Arg Lys Glu Ser Val Leu Ala 
    850                 855                 860                 


Gly Cys Glu Phe Pro Leu His Gln Glu Asn Ser Glu Met Cys Lys Val 
865                 870                 875                 880 


Val Phe Ala Pro Gln Pro Asp Ser Thr Ser Ser Gly Trp Phe 
                885                 890                 


<210>  822
<211>  151
<212>  PRT
<213>  Homo sapiens

<400>  822

Met Ile Leu Leu Ala Val Leu Phe Leu Cys Phe Ile Ser Ser Tyr Ser 
1               5                   10                  15      


Ala Ser Val Lys Gly His Thr Thr Gly Leu Ser Leu Asn Asn Asp Arg 
            20                  25                  30          


Leu Tyr Lys Leu Thr Tyr Ser Thr Glu Val Leu Leu Asp Arg Gly Lys 
        35                  40                  45              


Gly Lys Leu Gln Asp Ser Val Gly Tyr Arg Ile Ser Ser Asn Val Asp 
    50                  55                  60                  


Val Ala Leu Leu Trp Arg Asn Pro Asp Gly Asp Asp Asp Gln Leu Ile 
65                  70                  75                  80  


Gln Ile Thr Met Lys Asp Val Asn Val Glu Asn Val Asn Gln Gln Arg 
                85                  90                  95      


Gly Glu Lys Ser Ile Phe Lys Gly Lys Ser Pro Ser Lys Ile Met Gly 
            100                 105                 110         


Lys Glu Asn Leu Glu Ala Leu Gln Arg Pro Thr Leu Leu His Leu Ile 
        115                 120                 125             


His Gly Lys Val Lys Gly Arg Leu Asp Ser Thr Thr Phe Ser Pro Thr 
    130                 135                 140                 


Ser Tyr Phe Ser Ser Leu Gln 
145                 150     


<210>  823
<211>  1889
<212>  DNA
<213>  Homo sapiens

<400>  823
gtccctctga gtcttgctcc ctcatctgtc aagtgtagaa atagttgtat gataaaatca       60

ttactactta taaggttgct gggtgaatga caaatttgaa agtatttgaa tgtaataggc      120

aatgcttagt atgatatttt tattttatat tccctaacac tcagtataaa agcaaatctg      180

aatgcaatta agctcttcaa atcaaatgcc tggatttatt tctttgattg ttgtttttgc      240

cctgaaagtt ctatgtccta gataaatgtg tgccttagat aactgaatga ctttctcata      300

tgcaaagaag gcaccagctt tctctctctc agatctttct acatctccag gatgactgta      360

gccctgcaga aaataacact tgttctctag ttgtgcctaa gtaccatttg gaaagaggtg      420

gcctagatga gtgcaatgac cacccataaa gccatacaga ccagcaagaa gaataagcaa      480

aactatacca aacccacaac ctcggtctag ctagaagata gagaatccta caatcttcag      540

atcacgtgta gataaaaaac gttgacacca aatcccagca gagctgaatg tcacactgtg      600

gccacaagct ctgggaaaac agtatggaag agagaagagg gaagtgtcag tggagtcaaa      660

gattgattgg aggctgttgg tggaaagaac gtcaatcttt tgcataaaat actgtaaaga      720

ttcctggtga gccacagcac tgacaatgag gatgggaccc ctaagtccca gccttgtgcc      780

tgtgcacgat tgaaggcagc agtctgggag gcattgctta gggcagaaaa ggacacaaag      840

gaagagagaa gagagaaaca gccattggaa actgggtggt aaaacaaaga ggaagcaaaa      900

gatgggaaat ttcagatcct gcaagaaaaa agagatacga aaagttggaa gacacacaac      960

ctctctcact ttcactccca aataataata aaataaaaag gtaaagagga agtatactta     1020

gttacactca cagaaaagaa ttctcttaaa ccaggagggt tgtaaatagt ataaatccat     1080

gaaataaaag aacctaaatc tatatcaaat taccataaaa gaaagtagaa caatgagata     1140

ccatctcatg ccagtcagaa tggtgattat taaaatgtca agaaacaaca gatgctggca     1200

aggttgcaga gaagtaggaa cgctttcaca ctgctggtgg gagtataaat tagttcaacc     1260

attgtggaag acagtgtggt gattcctcaa agatttagaa ccagaaatac catttgaccc     1320

agcaatccca ttactggata tgtactcaaa ggaatataaa tcattctatt ataaagacat     1380

atgcacgtgt atgttcactg cagcactatt cacaatagca aagacatgga atcaaaccaa     1440

atgcccatca atgatagact ggataaagaa aatgtggtac atatataccg tggaatacta     1500

tgcagccata aaaaggaatg agatcatttc cttttcaggg acatggatga agctggaagc     1560

cattatcttc agcaaactaa cacaagaaca gaaaaccaaa cactgcatgt tctcacttac     1620

aagtgggagc cgaacattga gaacacatgg acacaggaag gggaactatc taacactggg     1680

gcttgttgtg gggttgttgg gagaaagaga gcatcaggga aactagctaa tgcatgctgg     1740

gcttaatacc taggtgatgg gttgataggt gcagcaaacc accatagcac acatttacct     1800

atgtaacaaa cctgcgcatc ctgcacatgt atcccagaac ttaaaaaaat aaaataaaca     1860

acaacgacaa caacaaaaaa aaaaaaaaa                                       1889


<210>  824
<211>  27
<212>  PRT
<213>  Homo sapiens

<400>  824

Met Ser Ala Met Thr Thr His Lys Ala Ile Gln Thr Ser Lys Lys Asn 
1               5                   10                  15      


Lys Gln Asn Tyr Thr Lys Pro Thr Thr Ser Val 
            20                  25          


<210>  825
<211>  27
<212>  PRT
<213>  Homo sapiens

<400>  825

Met Ser Ala Met Thr Thr His Lys Ala Ile Gln Thr Ser Lys Lys Asn 
1               5                   10                  15      


Lys Gln Asn Tyr Thr Lys Pro Thr Thr Ser Val 
            20                  25          


<210>  826
<211>  540
<212>  DNA
<213>  Homo sapiens

<400>  826
gtccgcgtcg ctagctagtc gttctgaagc ggcggccaga gaagagtcaa gggcacgagc       60

atcgggtagc catgcctttc ttggacatcc agaaaaggtt cggccttaac atagatcgat      120

ggttgacaat ccagagtggt gaacagccct acaagatggc tggtcgatgc catgcttttg      180

aaaaagaatg gatagaatgt gcacatggaa tcggttatac tcgggcagag aaagagtgca      240

agatagaata tgatgatttc gtagagtgtt tgcttcggca gaaaacgatg agacgtgcag      300

gtaccatcag gaagcagcgg gataagctga taaaggaagg aaagtacacc cctccacctc      360

accacattgg caagggggag cctcggccct gaacagagca gctgctgatg tctggaggct      420

gattttcctg ttctctgttc tccactggaa aggttgttta cgacaaacct ccttgtcaaa      480

gtgtgtaaaa ataaaggatt gctccatcct aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa      540


<210>  827
<211>  106
<212>  PRT
<213>  Homo sapiens

<400>  827

Met Pro Phe Leu Asp Ile Gln Lys Arg Phe Gly Leu Asn Ile Asp Arg 
1               5                   10                  15      


Trp Leu Thr Ile Gln Ser Gly Glu Gln Pro Tyr Lys Met Ala Gly Arg 
            20                  25                  30          


Cys His Ala Phe Glu Lys Glu Trp Ile Glu Cys Ala His Gly Ile Gly 
        35                  40                  45              


Tyr Thr Arg Ala Glu Lys Glu Cys Lys Ile Glu Tyr Asp Asp Phe Val 
    50                  55                  60                  


Glu Cys Leu Leu Arg Gln Lys Thr Met Arg Arg Ala Gly Thr Ile Arg 
65                  70                  75                  80  


Lys Gln Arg Asp Lys Leu Ile Lys Glu Gly Lys Tyr Thr Pro Pro Pro 
                85                  90                  95      


His His Ile Gly Lys Gly Glu Pro Arg Pro 
            100                 105     


<210>  828
<211>  106
<212>  PRT
<213>  Homo sapiens

<400>  828

Met Pro Phe Leu Asp Ile Gln Lys Arg Phe Gly Leu Asn Ile Asp Arg 
1               5                   10                  15      


Trp Leu Thr Ile Gln Ser Gly Glu Gln Pro Tyr Lys Met Ala Gly Arg 
            20                  25                  30          


Cys His Ala Phe Glu Lys Glu Trp Ile Glu Cys Ala His Gly Ile Gly 
        35                  40                  45              


Tyr Thr Arg Ala Glu Lys Glu Cys Lys Ile Glu Tyr Asp Asp Phe Val 
    50                  55                  60                  


Glu Cys Leu Leu Arg Gln Lys Thr Met Arg Arg Ala Gly Thr Ile Arg 
65                  70                  75                  80  


Lys Gln Arg Asp Lys Leu Ile Lys Glu Gly Lys Tyr Thr Pro Pro Pro 
                85                  90                  95      


His His Ile Gly Lys Gly Glu Pro Arg Pro 
            100                 105     


<210>  829
<211>  599
<212>  DNA
<213>  Homo sapiens

<400>  829
aggccgcgct cgcgccgagg ggctgcgaga gtgaccgcgg ctgctccagc gctgacgccg       60

agccatggcg gacgaggagc ttgaggcgct gaggagacag aggctggccg agctgcaggc      120

caaacacggg gatcctggtg atgcggccca acaggaagca aagcacaggg aagcagaaat      180

gagaaacagt atcttagccc aagttctgga tcagtcggcc cgggccaggt taagtaactt      240

agcacttgta aagcctgaaa aaactaaagc agtagagaat taccttatac agatggcaag      300

atatggacaa ctaagtgaga aggtatcaga acaaggttta atagaaatcc ttaaaaaagt      360

aagccaacaa acagaaaaga caacaacagt gaaattcaac agaagaaaag taatggactc      420

tgatgaagat gacgattatt gaactacaag tgctcacaga ctagaactta acggaacaag      480

tctaggacag aagttaagat ctgattattt actttgttta ttgtctatat gccttttaaa      540

aaaataaact tgttatgcaa aataaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaa       599


<210>  830
<211>  125
<212>  PRT
<213>  Homo sapiens

<400>  830

Met Ala Asp Glu Glu Leu Glu Ala Leu Arg Arg Gln Arg Leu Ala Glu 
1               5                   10                  15      


Leu Gln Ala Lys His Gly Asp Pro Gly Asp Ala Ala Gln Gln Glu Ala 
            20                  25                  30          


Lys His Arg Glu Ala Glu Met Arg Asn Ser Ile Leu Ala Gln Val Leu 
        35                  40                  45              


Asp Gln Ser Ala Arg Ala Arg Leu Ser Asn Leu Ala Leu Val Lys Pro 
    50                  55                  60                  


Glu Lys Thr Lys Ala Val Glu Asn Tyr Leu Ile Gln Met Ala Arg Tyr 
65                  70                  75                  80  


Gly Gln Leu Ser Glu Lys Val Ser Glu Gln Gly Leu Ile Glu Ile Leu 
                85                  90                  95      


Lys Lys Val Ser Gln Gln Thr Glu Lys Thr Thr Thr Val Lys Phe Asn 
            100                 105                 110         


Arg Arg Lys Val Met Asp Ser Asp Glu Asp Asp Asp Tyr 
        115                 120                 125 


<210>  831
<211>  125
<212>  PRT
<213>  Homo sapiens

<400>  831

Met Ala Asp Glu Glu Leu Glu Ala Leu Arg Arg Gln Arg Leu Ala Glu 
1               5                   10                  15      


Leu Gln Ala Lys His Gly Asp Pro Gly Asp Ala Ala Gln Gln Glu Ala 
            20                  25                  30          


Lys His Arg Glu Ala Glu Met Arg Asn Ser Ile Leu Ala Gln Val Leu 
        35                  40                  45              


Asp Gln Ser Ala Arg Ala Arg Leu Ser Asn Leu Ala Leu Val Lys Pro 
    50                  55                  60                  


Glu Lys Thr Lys Ala Val Glu Asn Tyr Leu Ile Gln Met Ala Arg Tyr 
65                  70                  75                  80  


Gly Gln Leu Ser Glu Lys Val Ser Glu Gln Gly Leu Ile Glu Ile Leu 
                85                  90                  95      


Lys Lys Val Ser Gln Gln Thr Glu Lys Thr Thr Thr Val Lys Phe Asn 
            100                 105                 110         


Arg Arg Lys Val Met Asp Ser Asp Glu Asp Asp Asp Tyr 
        115                 120                 125 


<210>  832
<211>  1455
<212>  DNA
<213>  Homo sapiens

<400>  832
ggataagttt ataccatgga tagcacaaag gagaagtgtg acagttacaa agatgatctt       60

ctgcttagga tgggacttaa tgataataaa gcaggaatgg aaggattaga taaagagaaa      120

attaacaaaa ttataatgga agccacgaag gggtccagat tttatggaaa tgagctcaag      180

aaagaaaagc aagtcaacca acgaattgaa aatatgatgc aacaaaaagc tcaaatcacc      240

agccaacagc taagaaaagc acaattacag gttgacagat ttgcaatgga attagaacaa      300

agccgaaatt tgagcaatac catagtgcac attgacatgg atgctttcta tgcagctgta      360

gaaatgaggg acaatccaga attgaaggat aaacccattg ctgtaggatc aatgagtatg      420

ctgtctactt caaattacca tgcaaggaga tttggtgttc gtgcagccat gccaggattt      480

attgctaaga ggctgtgccc acaacttata atagtgcccc ccaactttga caaataccga      540

gctgtgagta aagaggttaa ggaaatactt gctgattatg atcccaattt tatggccatg      600

agtcttgatg aagcctactt gaatataaca aagcacttag aagaaagaca aaattggcct      660

gaggataaaa gaaggtattt catcaaaatg ggaagctctg tagaaaatga taatccagga      720

aaggaagtta ataaactgag tgagcatgaa cgatccatct ctccactact ttttgaagag      780

agtccttctg atgtgcagcc cccaggagat cctttccaag tgaactttga agaacaaaac      840

aatcctcaaa tactccaaaa ctcagttgtt tttggaacat cagcccagga agtggtaaag      900

gaaattcgtt tcagaattga gcagaaaaca acactgacag ccagtgcagg cattgcccca      960

aatacaatgt tagcaaaagt atgcagtgat aagaataaac caaatggaca ataccaaatt     1020

cttcccaata gacaagctgt gatggacttc atcaaggatt tacccattag aaaggtttct     1080

ggaataggaa aagttacaga gaaaatgtta aaggcccttg gaattattac atgtacagaa     1140

ctttaccaac agagggcatt gctttctctc cttttctctg aaacatcttg gcattatttc     1200

cttcatatct ccttgggtct aggttcaaca cacctgacga gggatggaga gaggaaaagt     1260

atgagcgttg agaggacatt cagtgagata aataaagcgg aagagcaata cagcctatgt     1320

caagaacttt gcagtgagct tgctcaggat ctacagaaag aaagacttaa ggtgctttat     1380

tttgatatgg tgtccttagt ttttaagttt tttaatagta aaatgctacc ttaaaagcta     1440

aaaaaaaaaa aaaaa                                                      1455


<210>  833
<211>  870
<212>  PRT
<213>  Homo sapiens

<400>  833

Met Asp Ser Thr Lys Glu Lys Cys Asp Ser Tyr Lys Asp Asp Leu Leu 
1               5                   10                  15      


Leu Arg Met Gly Leu Asn Asp Asn Lys Ala Gly Met Glu Gly Leu Asp 
            20                  25                  30          


Lys Glu Lys Ile Asn Lys Ile Ile Met Glu Ala Thr Lys Gly Ser Arg 
        35                  40                  45              


Phe Tyr Gly Asn Glu Leu Lys Lys Glu Lys Gln Val Asn Gln Arg Ile 
    50                  55                  60                  


Glu Asn Met Met Gln Gln Lys Ala Gln Ile Thr Ser Gln Gln Leu Arg 
65                  70                  75                  80  


Lys Ala Gln Leu Gln Val Asp Arg Phe Ala Met Glu Leu Glu Gln Ser 
                85                  90                  95      


Arg Asn Leu Ser Asn Thr Ile Val His Ile Asp Met Asp Ala Phe Tyr 
            100                 105                 110         


Ala Ala Val Glu Met Arg Asp Asn Pro Glu Leu Lys Asp Lys Pro Ile 
        115                 120                 125             


Ala Val Gly Ser Met Ser Met Leu Ser Thr Ser Asn Tyr His Ala Arg 
    130                 135                 140                 


Arg Phe Gly Val Arg Ala Ala Met Pro Gly Phe Ile Ala Lys Arg Leu 
145                 150                 155                 160 


Cys Pro Gln Leu Ile Ile Val Pro Pro Asn Phe Asp Lys Tyr Arg Ala 
                165                 170                 175     


Val Ser Lys Glu Val Lys Glu Ile Leu Ala Asp Tyr Asp Pro Asn Phe 
            180                 185                 190         


Met Ala Met Ser Leu Asp Glu Ala Tyr Leu Asn Ile Thr Lys His Leu 
        195                 200                 205             


Glu Glu Arg Gln Asn Trp Pro Glu Asp Lys Arg Arg Tyr Phe Ile Lys 
    210                 215                 220                 


Met Gly Ser Ser Val Glu Asn Asp Asn Pro Gly Lys Glu Val Asn Lys 
225                 230                 235                 240 


Leu Ser Glu His Glu Arg Ser Ile Ser Pro Leu Leu Phe Glu Glu Ser 
                245                 250                 255     


Pro Ser Asp Val Gln Pro Pro Gly Asp Pro Phe Gln Val Asn Phe Glu 
            260                 265                 270         


Glu Gln Asn Asn Pro Gln Ile Leu Gln Asn Ser Val Val Phe Gly Thr 
        275                 280                 285             


Ser Ala Gln Glu Val Val Lys Glu Ile Arg Phe Arg Ile Glu Gln Lys 
    290                 295                 300                 


Thr Thr Leu Thr Ala Ser Ala Gly Ile Ala Pro Asn Thr Met Leu Ala 
305                 310                 315                 320 


Lys Val Cys Ser Asp Lys Asn Lys Pro Asn Gly Gln Tyr Gln Ile Leu 
                325                 330                 335     


Pro Asn Arg Gln Ala Val Met Asp Phe Ile Lys Asp Leu Pro Ile Arg 
            340                 345                 350         


Lys Val Ser Gly Ile Gly Lys Val Thr Glu Lys Met Leu Lys Ala Leu 
        355                 360                 365             


Gly Ile Ile Thr Cys Thr Glu Leu Tyr Gln Gln Arg Ala Leu Leu Ser 
    370                 375                 380                 


Leu Leu Phe Ser Glu Thr Ser Trp His Tyr Phe Leu His Ile Ser Leu 
385                 390                 395                 400 


Gly Leu Gly Ser Thr His Leu Thr Arg Asp Gly Glu Arg Lys Ser Met 
                405                 410                 415     


Ser Val Glu Arg Thr Phe Ser Glu Ile Asn Lys Ala Glu Glu Gln Tyr 
            420                 425                 430         


Ser Leu Cys Gln Glu Leu Cys Ser Glu Leu Ala Gln Asp Leu Gln Lys 
        435                 440                 445             


Glu Arg Leu Lys Gly Arg Thr Val Thr Ile Lys Leu Lys Asn Val Asn 
    450                 455                 460                 


Phe Glu Val Lys Thr Arg Ala Ser Thr Val Ser Ser Val Val Ser Thr 
465                 470                 475                 480 


Ala Glu Glu Ile Phe Ala Ile Ala Lys Glu Leu Leu Lys Thr Glu Ile 
                485                 490                 495     


Asp Ala Asp Phe Pro His Pro Leu Arg Leu Arg Leu Met Gly Val Arg 
            500                 505                 510         


Ile Ser Ser Phe Pro Asn Glu Glu Asp Arg Lys His Gln Gln Arg Ser 
        515                 520                 525             


Ile Ile Gly Phe Leu Gln Ala Gly Asn Gln Ala Leu Ser Ala Thr Glu 
    530                 535                 540                 


Cys Thr Leu Glu Lys Thr Asp Lys Asp Lys Phe Val Lys Pro Leu Glu 
545                 550                 555                 560 


Met Ser His Lys Lys Ser Phe Phe Asp Lys Lys Arg Ser Glu Arg Lys 
                565                 570                 575     


Trp Ser His Gln Asp Thr Phe Lys Cys Glu Ala Val Asn Lys Gln Ser 
            580                 585                 590         


Phe Gln Thr Ser Gln Pro Phe Gln Val Leu Lys Lys Lys Met Asn Glu 
        595                 600                 605             


Asn Leu Glu Ile Ser Glu Asn Ser Asp Asp Cys Gln Ile Leu Thr Cys 
    610                 615                 620                 


Pro Val Cys Phe Arg Ala Gln Gly Cys Ile Ser Leu Glu Ala Leu Asn 
625                 630                 635                 640 


Lys His Val Asp Glu Cys Leu Asp Gly Pro Ser Ile Ser Glu Asn Phe 
                645                 650                 655     


Lys Met Phe Ser Cys Ser His Val Ser Ala Thr Lys Val Asn Lys Lys 
            660                 665                 670         


Glu Asn Val Pro Ala Ser Ser Leu Cys Glu Lys Gln Asp Tyr Glu Ala 
        675                 680                 685             


His Pro Lys Ile Lys Glu Ile Ser Ser Val Asp Cys Ile Ala Leu Val 
    690                 695                 700                 


Asp Thr Ile Asp Asn Ser Ser Lys Ala Glu Ser Ile Asp Ala Leu Ser 
705                 710                 715                 720 


Asn Lys His Ser Lys Glu Glu Cys Ser Ser Leu Pro Ser Lys Ser Phe 
                725                 730                 735     


Asn Ile Glu His Cys His Gln Asn Ser Ser Ser Thr Val Ser Leu Glu 
            740                 745                 750         


Asn Glu Asp Val Gly Ser Phe Arg Gln Glu Tyr Arg Gln Pro Tyr Leu 
        755                 760                 765             


Cys Glu Val Lys Thr Gly Gln Ala Leu Val Cys Pro Val Cys Asn Val 
    770                 775                 780                 


Glu Gln Lys Thr Ser Asp Leu Thr Leu Phe Asn Val His Val Asp Val 
785                 790                 795                 800 


Cys Leu Asn Lys Ser Phe Ile Gln Glu Leu Arg Lys Asp Lys Phe Asn 
                805                 810                 815     


Pro Val Asn Gln Pro Lys Glu Ser Ser Arg Ser Thr Gly Ser Ser Ser 
            820                 825                 830         


Gly Val Gln Lys Ala Val Thr Arg Thr Lys Arg Pro Gly Leu Met Thr 
        835                 840                 845             


Lys Tyr Ser Thr Ser Lys Lys Ile Lys Pro Asn Asn Pro Lys His Thr 
    850                 855                 860                 


Leu Asp Ile Phe Phe Lys 
865                 870 


<210>  834
<211>  472
<212>  PRT
<213>  Homo sapiens

<400>  834

Met Asp Ser Thr Lys Glu Lys Cys Asp Ser Tyr Lys Asp Asp Leu Leu 
1               5                   10                  15      


Leu Arg Met Gly Leu Asn Asp Asn Lys Ala Gly Met Glu Gly Leu Asp 
            20                  25                  30          


Lys Glu Lys Ile Asn Lys Ile Ile Met Glu Ala Thr Lys Gly Ser Arg 
        35                  40                  45              


Phe Tyr Gly Asn Glu Leu Lys Lys Glu Lys Gln Val Asn Gln Arg Ile 
    50                  55                  60                  


Glu Asn Met Met Gln Gln Lys Ala Gln Ile Thr Ser Gln Gln Leu Arg 
65                  70                  75                  80  


Lys Ala Gln Leu Gln Val Asp Arg Phe Ala Met Glu Leu Glu Gln Ser 
                85                  90                  95      


Arg Asn Leu Ser Asn Thr Ile Val His Ile Asp Met Asp Ala Phe Tyr 
            100                 105                 110         


Ala Ala Val Glu Met Arg Asp Asn Pro Glu Leu Lys Asp Lys Pro Ile 
        115                 120                 125             


Ala Val Gly Ser Met Ser Met Leu Ser Thr Ser Asn Tyr His Ala Arg 
    130                 135                 140                 


Arg Phe Gly Val Arg Ala Ala Met Pro Gly Phe Ile Ala Lys Arg Leu 
145                 150                 155                 160 


Cys Pro Gln Leu Ile Ile Val Pro Pro Asn Phe Asp Lys Tyr Arg Ala 
                165                 170                 175     


Val Ser Lys Glu Val Lys Glu Ile Leu Ala Asp Tyr Asp Pro Asn Phe 
            180                 185                 190         


Met Ala Met Ser Leu Asp Glu Ala Tyr Leu Asn Ile Thr Lys His Leu 
        195                 200                 205             


Glu Glu Arg Gln Asn Trp Pro Glu Asp Lys Arg Arg Tyr Phe Ile Lys 
    210                 215                 220                 


Met Gly Ser Ser Val Glu Asn Asp Asn Pro Gly Lys Glu Val Asn Lys 
225                 230                 235                 240 


Leu Ser Glu His Glu Arg Ser Ile Ser Pro Leu Leu Phe Glu Glu Ser 
                245                 250                 255     


Pro Ser Asp Val Gln Pro Pro Gly Asp Pro Phe Gln Val Asn Phe Glu 
            260                 265                 270         


Glu Gln Asn Asn Pro Gln Ile Leu Gln Asn Ser Val Val Phe Gly Thr 
        275                 280                 285             


Ser Ala Gln Glu Val Val Lys Glu Ile Arg Phe Arg Ile Glu Gln Lys 
    290                 295                 300                 


Thr Thr Leu Thr Ala Ser Ala Gly Ile Ala Pro Asn Thr Met Leu Ala 
305                 310                 315                 320 


Lys Val Cys Ser Asp Lys Asn Lys Pro Asn Gly Gln Tyr Gln Ile Leu 
                325                 330                 335     


Pro Asn Arg Gln Ala Val Met Asp Phe Ile Lys Asp Leu Pro Ile Arg 
            340                 345                 350         


Lys Val Ser Gly Ile Gly Lys Val Thr Glu Lys Met Leu Lys Ala Leu 
        355                 360                 365             


Gly Ile Ile Thr Cys Thr Glu Leu Tyr Gln Gln Arg Ala Leu Leu Ser 
    370                 375                 380                 


Leu Leu Phe Ser Glu Thr Ser Trp His Tyr Phe Leu His Ile Ser Leu 
385                 390                 395                 400 


Gly Leu Gly Ser Thr His Leu Thr Arg Asp Gly Glu Arg Lys Ser Met 
                405                 410                 415     


Ser Val Glu Arg Thr Phe Ser Glu Ile Asn Lys Ala Glu Glu Gln Tyr 
            420                 425                 430         


Ser Leu Cys Gln Glu Leu Cys Ser Glu Leu Ala Gln Asp Leu Gln Lys 
        435                 440                 445             


Glu Arg Leu Lys Val Leu Tyr Phe Asp Met Val Ser Leu Val Phe Lys 
    450                 455                 460                 


Phe Phe Asn Ser Lys Met Leu Pro 
465                 470         


<210>  835
<211>  458
<212>  DNA
<213>  Homo sapiens

<400>  835
gaaggctggg agggctgcgc gggctgcgcg tcgccatgga gcccgacggg acttacgagc       60

cgggcttcgt gggtattcgc ttctgccagg aatgtaacaa catgctgtac cccaaggaag      120

acaaggagaa ccgcattctg ctctacgcgt gccggaactg tgattaccag caggaggccg      180

acaacagctg catctatgtc aacaagatca cgcacgaagt ggacgaactg acccagatta      240

tcgccgacgt gtcccaggac cccacgttgc cgcggaccga ggaccacccg tgccaaaagt      300

gcggccacaa ggaggctgtg ttcttccagt cacacagtgc gcgggccgag gacgccatgc      360

gcctttacta cgtgtgcaca gccccacact gcggccaccg ctggaccgag tgacctcctc      420

tctcccccga gtgtaataaa caccagattc catgcgtg                              458


<210>  836
<211>  125
<212>  PRT
<213>  Homo sapiens

<400>  836

Met Glu Pro Asp Gly Thr Tyr Glu Pro Gly Phe Val Gly Ile Arg Phe 
1               5                   10                  15      


Cys Gln Glu Cys Asn Asn Met Leu Tyr Pro Lys Glu Asp Lys Glu Asn 
            20                  25                  30          


Arg Ile Leu Leu Tyr Ala Cys Arg Asn Cys Asp Tyr Gln Gln Glu Ala 
        35                  40                  45              


Asp Asn Ser Cys Ile Tyr Val Asn Lys Ile Thr His Glu Val Asp Glu 
    50                  55                  60                  


Leu Thr Gln Ile Ile Ala Asp Val Ser Gln Asp Pro Thr Leu Pro Arg 
65                  70                  75                  80  


Thr Glu Asp His Pro Cys Gln Lys Cys Gly His Lys Glu Ala Val Phe 
                85                  90                  95      


Phe Gln Ser His Ser Ala Arg Ala Glu Asp Ala Met Arg Leu Tyr Tyr 
            100                 105                 110         


Val Cys Thr Ala Pro His Cys Gly His Arg Trp Thr Glu 
        115                 120                 125 


<210>  837
<211>  125
<212>  PRT
<213>  Homo sapiens

<400>  837

Met Glu Pro Asp Gly Thr Tyr Glu Pro Gly Phe Val Gly Ile Arg Phe 
1               5                   10                  15      


Cys Gln Glu Cys Asn Asn Met Leu Tyr Pro Lys Glu Asp Lys Glu Asn 
            20                  25                  30          


Arg Ile Leu Leu Tyr Ala Cys Arg Asn Cys Asp Tyr Gln Gln Glu Ala 
        35                  40                  45              


Asp Asn Ser Cys Ile Tyr Val Asn Lys Ile Thr His Glu Val Asp Glu 
    50                  55                  60                  


Leu Thr Gln Ile Ile Ala Asp Val Ser Gln Asp Pro Thr Leu Pro Arg 
65                  70                  75                  80  


Thr Glu Asp His Pro Cys Gln Lys Cys Gly His Lys Glu Ala Val Phe 
                85                  90                  95      


Phe Gln Ser His Ser Ala Arg Ala Glu Asp Ala Met Arg Leu Tyr Tyr 
            100                 105                 110         


Val Cys Thr Ala Pro His Cys Gly His Arg Trp Thr Glu 
        115                 120                 125 


<210>  838
<211>  2661
<212>  DNA
<213>  Homo sapiens

<400>  838
ccggcaccga catggcggcc gtcttcgctg tggtgacttt aactctcggt tttcggttct       60

agccggccgg cgctcacttg tcttcaggaa gctcggagcc tttggtggag ccggggagag      120

gaagggtggg tgcaagagtg aaaggcgaga ggggactgca agcatccggg tcgctgctgg      180

ccggagcaga tggctgaggg cgagcggcag ccgccgccag attcttcaga ggaggcccct      240

ccagccactc agaacttcat cattccaaaa aaggagatcc acacagttcc agacatgggc      300

aaatggaagc gttctcaggc atacgctgac tacatcggat tcatccttac cctcaacgaa      360

ggtgtgaagg ggaagaagct gaccttcgag tacagagtct ccgaggccat tgagaaacta      420

ctcgctcttc tcaacacgct ggacaggtgg attgatgaga ctcctccagt ggaccagccc      480

tctcggtttg ggaataaggc atacaggacc tggtatgcca aacttgatga ggaagcagaa      540

aacttggtgg ccacagtggt ccctacccat ctggcagctg ctgtgcctga ggtggctgtt      600

tacctaaagg agtcagtggg gaactccacg cgcattgact acggcacagg gcatgaggca      660

gccttcgctg ctttcctctg ctgtctctgc aagattgggg tgctccgggt ggatgaccaa      720

atagctattg tcttcaaggt gttcaatcgg taccttgagg ttatgcggaa actccagaaa      780

acatacagga tggagccagc cggcagccag ggagtgtggg gtctggatga cttccagttt      840

ctgcccttca tctggggcag ttcgcagctg atagaccacc catacctgga gcccagacac      900

tttgtggatg agaaggccgt gaatgagaac cacaaggact acatgttcct ggagtgtatc      960

ctgtttatta ccgagatgaa gactggccca tttgcagagc actccaacca gctgtggaac     1020

atcagcgccg tgccttcctg gtccaaagtg aaccagggtc tcatccgcat gtataaggcc     1080

gagtgcctgg agaagttccc tgtgatccag cacttcaagt tcgggagcct gctgcccatc     1140

catcctgtca cgtcgggcta ggagggccaa gccgaagagc cacccaggcc acagttcctg     1200

tgcctgcctt ccccacccca gcagtggccc ctcccccatc ccctccctct gttcgtcccg     1260

tttgatgaga ggctgtttac tggggtgggg tggcgagatg ggcttgaggg ggctcagagc     1320

ataaggcttc agggcccaag ttgggagaag tgaccaaagt gtagccagtt ttctgagttc     1380

ccgtgtgcta gactggccag aagagagggt ctggggcctg gtcactcggc cactctctcc     1440

tgtttctggc ctcttctccc ttcactcccg gtccagtctg gttttgagag caggggctgt     1500

tctgcagcac ctcagggaag ggaggagaga tacctgctgc ttccattgct tttcccttcc     1560

tggagtcgat gcctttctaa gggttggagc tgctccttgc aggggcgggt cagtttccca     1620

ggccatgccg gggtggccat ctatgctagg gctggaagct gagctggccg ccagctgtgg     1680

gctggggtgg ggtgggtggg gtcgggtggt ggagaggcct tagctgtcct gctggtgccc     1740

ctcccaggct ccttttcacc ctgccccctg cctgaggccc cctgtgtcca agcctccccc     1800

tggctcttca gttctctagc ccttggcttt gctgggtttc ctgactgtag ccacatctct     1860

cccgctccct aagggtaacc tagccaatgg aagctggcct ttgggtaggt gctgggctcc     1920

tgggagggcc cagatgatgg gtgaggcatg tctttccaga actttcctgg cagggagggg     1980

atggcagaaa ctcagggagg cttggggccc attgtatctg gagagcctgg attcctcttg     2040

gcagtcttag cccagccact tctgctacct ttgcgctgct gtgagcctca ccctgcccct     2100

gggccctgct tctctgctcc cctgggtgat gggtgggccc agaaggtggc agtcccacac     2160

cttgtcctcc cacctccctg aactgtccat tgcttttata gggtgaggta agtgacagcc     2220

tcccaagccc aggctttggc actcagaatg ggcccagtgg gggctgggca gcccattgag     2280

ggccaccgcc gaggcgcgag gtttctccta gggctgttcc tgggcctggc tcttacaggc     2340

ttggtcagga gggctggcct tcttcactgc cccctcctgt gtctgggtcc acacaccctt     2400

cagtaaccaa cggcactgag aagcacagca caggggctca gcctgggatc cggtgatggt     2460

ctgggcagag gctgggtcag gagtcccaaa ggtcagtgac agtttctcag aagaggccca     2520

gcgtccacct ctctcccagg gccagacacc ccttcctggc tcccccatcc ccctatggct     2580

cccagcccct tgcaccctca ttgctgttca gattaaagcc tctgttttgc acctgtcaaa     2640

aaaaaaaaaa aaaaaaaaaa a                                               2661


<210>  839
<211>  358
<212>  PRT
<213>  Homo sapiens

<400>  839

Met Ala Glu Gly Glu Arg Gln Pro Pro Pro Asp Ser Ser Glu Glu Ala 
1               5                   10                  15      


Pro Pro Ala Thr Gln Asn Phe Ile Ile Pro Lys Lys Glu Ile His Thr 
            20                  25                  30          


Val Pro Asp Met Gly Lys Trp Lys Arg Ser Gln Ala Tyr Ala Asp Tyr 
        35                  40                  45              


Ile Gly Phe Ile Leu Thr Leu Asn Glu Gly Val Lys Gly Lys Lys Leu 
    50                  55                  60                  


Thr Phe Glu Tyr Arg Val Ser Glu Met Trp Asn Glu Val His Glu Glu 
65                  70                  75                  80  


Lys Glu Gln Ala Ala Lys Gln Ser Val Ser Cys Asp Glu Cys Ile Pro 
                85                  90                  95      


Leu Pro Arg Ala Gly His Cys Ala Pro Ser Glu Ala Ile Glu Lys Leu 
            100                 105                 110         


Val Ala Leu Leu Asn Thr Leu Asp Arg Trp Ile Asp Glu Thr Pro Pro 
        115                 120                 125             


Val Asp Gln Pro Ser Arg Phe Gly Asn Lys Ala Tyr Arg Thr Trp Tyr 
    130                 135                 140                 


Ala Lys Leu Asp Glu Glu Ala Glu Asn Leu Val Ala Thr Val Val Pro 
145                 150                 155                 160 


Thr His Leu Ala Ala Ala Val Pro Glu Val Ala Val Tyr Leu Lys Glu 
                165                 170                 175     


Ser Val Gly Asn Ser Thr Arg Ile Asp Tyr Gly Thr Gly His Glu Ala 
            180                 185                 190         


Ala Phe Ala Ala Phe Leu Cys Cys Leu Cys Lys Ile Gly Val Leu Arg 
        195                 200                 205             


Val Asp Asp Gln Ile Ala Ile Val Phe Lys Val Phe Asn Arg Tyr Leu 
    210                 215                 220                 


Glu Val Met Arg Lys Leu Gln Lys Thr Tyr Arg Met Glu Pro Ala Gly 
225                 230                 235                 240 


Ser Gln Gly Val Trp Gly Leu Asp Asp Phe Gln Phe Leu Pro Phe Ile 
                245                 250                 255     


Trp Gly Ser Ser Gln Leu Ile Asp His Pro Tyr Leu Glu Pro Arg His 
            260                 265                 270         


Phe Val Asp Glu Lys Ala Val Asn Glu Asn His Lys Asp Tyr Met Phe 
        275                 280                 285             


Leu Glu Cys Ile Leu Phe Ile Thr Glu Met Lys Thr Gly Pro Phe Ala 
    290                 295                 300                 


Glu His Ser Asn Gln Leu Trp Asn Ile Ser Ala Val Pro Ser Trp Ser 
305                 310                 315                 320 


Lys Val Asn Gln Gly Leu Ile Arg Met Tyr Lys Ala Glu Cys Leu Glu 
                325                 330                 335     


Lys Phe Pro Val Ile Gln His Phe Lys Phe Gly Ser Leu Leu Pro Ile 
            340                 345                 350         


His Pro Val Thr Ser Gly 
        355             


<210>  840
<211>  323
<212>  PRT
<213>  Homo sapiens

<400>  840

Met Ala Glu Gly Glu Arg Gln Pro Pro Pro Asp Ser Ser Glu Glu Ala 
1               5                   10                  15      


Pro Pro Ala Thr Gln Asn Phe Ile Ile Pro Lys Lys Glu Ile His Thr 
            20                  25                  30          


Val Pro Asp Met Gly Lys Trp Lys Arg Ser Gln Ala Tyr Ala Asp Tyr 
        35                  40                  45              


Ile Gly Phe Ile Leu Thr Leu Asn Glu Gly Val Lys Gly Lys Lys Leu 
    50                  55                  60                  


Thr Phe Glu Tyr Arg Val Ser Glu Ala Ile Glu Lys Leu Val Ala Leu 
65                  70                  75                  80  


Leu Asn Thr Leu Asp Arg Trp Ile Asp Glu Thr Pro Pro Val Asp Gln 
                85                  90                  95      


Pro Ser Arg Phe Gly Asn Lys Ala Tyr Arg Thr Trp Tyr Ala Lys Leu 
            100                 105                 110         


Asp Glu Glu Ala Glu Asn Leu Val Ala Thr Val Val Pro Thr His Leu 
        115                 120                 125             


Ala Ala Ala Val Pro Glu Val Ala Val Tyr Leu Lys Glu Ser Val Gly 
    130                 135                 140                 


Asn Ser Thr Arg Ile Asp Tyr Gly Thr Gly His Glu Ala Ala Phe Ala 
145                 150                 155                 160 


Ala Phe Leu Cys Cys Leu Cys Lys Ile Gly Val Leu Arg Val Asp Asp 
                165                 170                 175     


Gln Ile Ala Ile Val Phe Lys Val Phe Asn Arg Tyr Leu Glu Val Met 
            180                 185                 190         


Arg Lys Leu Gln Lys Thr Tyr Arg Met Glu Pro Ala Gly Ser Gln Gly 
        195                 200                 205             


Val Trp Gly Leu Asp Asp Phe Gln Phe Leu Pro Phe Ile Trp Gly Ser 
    210                 215                 220                 


Ser Gln Leu Ile Asp His Pro Tyr Leu Glu Pro Arg His Phe Val Asp 
225                 230                 235                 240 


Glu Lys Ala Val Asn Glu Asn His Lys Asp Tyr Met Phe Leu Glu Cys 
                245                 250                 255     


Ile Leu Phe Ile Thr Glu Met Lys Thr Gly Pro Phe Ala Glu His Ser 
            260                 265                 270         


Asn Gln Leu Trp Asn Ile Ser Ala Val Pro Ser Trp Ser Lys Val Asn 
        275                 280                 285             


Gln Gly Leu Ile Arg Met Tyr Lys Ala Glu Cys Leu Glu Lys Phe Pro 
    290                 295                 300                 


Val Ile Gln His Phe Lys Phe Gly Ser Leu Leu Pro Ile His Pro Val 
305                 310                 315                 320 


Thr Ser Gly 
            


<210>  841
<211>  2661
<212>  DNA
<213>  Homo sapiens

<400>  841
ccggcaccga catggcggcc gtcttcgctg tggtgacttt aactctcggt tttcggttct       60

agccggccgg cgctcacttg tcttcaggaa gctcggagcc tttggtggag ccggggagag      120

gaagggtggg tgcaagagtg aaaggcgaga ggggactgca agcatccggg tcgctgctgg      180

ccggagcaga tggctgaggg cgagcggcag ccgccgccag attcttcaga ggaggcccct      240

ccagccactc agaacttcat cattccaaaa aaggagatcc acacagttcc agacatgggc      300

aaatggaagc gttctcaggc atacgctgac tacatcggat tcatccttac cctcaacgaa      360

ggtgtgaagg ggaagaagct gaccttcgag tacagagtct ccgaggccat tgagaaacta      420

ctcgctcttc tcaacacgct ggacaggtgg attgatgaga ctcctccagt ggaccagccc      480

tctcggtttg ggaataaggc atacaggacc tggtatgcca aacttgatga ggaagcagaa      540

aacttggtgg ccacagtggt ccctacccat ctggcagctg ctgtgcctga ggtggctgtt      600

tacctaaagg agtcagtggg gaactccacg cgcattgact acggcacagg gcatgaggca      660

gccttcgctg ctttcctctg ctgtctctgc aagattgggg tgctccgggt ggatgaccaa      720

atagctattg tcttcaaggt gttcaatcgg taccttgagg ttatgcggaa actccagaaa      780

acatacagga tggagccagc cggcagccag ggagtgtggg gtctggatga cttccagttt      840

ctgcccttca tctggggcag ttcgcagctg atagaccacc catacctgga gcccagacac      900

tttgtggatg agaaggccgt gaatgagaac cacaaggact acatgttcct ggagtgtatc      960

ctgtttatta ccgagatgaa gactggccca tttgcagagc actccaacca gctgtggaac     1020

atcagcgccg tgccttcctg gtccaaagtg aaccagggtc tcatccgcat gtataaggcc     1080

gagtgcctgg agaagttccc tgtgatccag cacttcaagt tcgggagcct gctgcccatc     1140

catcctgtca cgtcgggcta ggagggccaa gccgaagagc cacccaggcc acagttcctg     1200

tgcctgcctt ccccacccca gcagtggccc ctcccccatc ccctccctct gttcgtcccg     1260

tttgatgaga ggctgtttac tggggtgggg tggcgagatg ggcttgaggg ggctcagagc     1320

ataaggcttc agggcccaag ttgggagaag tgaccaaagt gtagccagtt ttctgagttc     1380

ccgtgtgcta gactggccag aagagagggt ctggggcctg gtcactcggc cactctctcc     1440

tgtttctggc ctcttctccc ttcactcccg gtccagtctg gttttgagag caggggctgt     1500

tctgcagcac ctcagggaag ggaggagaga tacctgctgc ttccattgct tttcccttcc     1560

tggagtcgat gcctttctaa gggttggagc tgctccttgc aggggcgggt cagtttccca     1620

ggccatgccg gggtggccat ctatgctagg gctggaagct gagctggccg ccagctgtgg     1680

gctggggtgg ggtgggtggg gtcgggtggt ggagaggcct tagctgtcct gctggtgccc     1740

ctcccaggct ccttttcacc ctgccccctg cctgaggccc cctgtgtcca agcctccccc     1800

tggctcttca gttctctagc ccttggcttt gctgggtttc ctgactgtag ccacatctct     1860

cccgctccct aagggtaacc tagccaatgg aagctggcct ttgggtaggt gctgggctcc     1920

tgggagggcc cagatgatgg gtgaggcatg tctttccaga actttcctgg cagggagggg     1980

atggcagaaa ctcagggagg cttggggccc attgtatctg gagagcctgg attcctcttg     2040

gcagtcttag cccagccact tctgctacct ttgcgctgct gtgagcctca ccctgcccct     2100

gggccctgct tctctgctcc cctgggtgat gggtgggccc agaaggtggc agtcccacac     2160

cttgtcctcc cacctccctg aactgtccat tgcttttata gggtgaggta agtgacagcc     2220

tcccaagccc aggctttggc actcagaatg ggcccagtgg gggctgggca gcccattgag     2280

ggccaccgcc gaggcgcgag gtttctccta gggctgttcc tgggcctggc tcttacaggc     2340

ttggtcagga gggctggcct tcttcactgc cccctcctgt gtctgggtcc acacaccctt     2400

cagtaaccaa cggcactgag aagcacagca caggggctca gcctgggatc cggtgatggt     2460

ctgggcagag gctgggtcag gagtcccaaa ggtcagtgac agtttctcag aagaggccca     2520

gcgtccacct ctctcccagg gccagacacc ccttcctggc tcccccatcc ccctatggct     2580

cccagcccct tgcaccctca ttgctgttca gattaaagcc tctgttttgc acctgtcaaa     2640

aaaaaaaaaa aaaaaaaaaa a                                               2661


<210>  842
<211>  509
<212>  PRT
<213>  Homo sapiens

<400>  842

Met Glu Arg Arg Arg Leu Trp Gly Ser Ile Gln Ser Arg Tyr Ile Ser 
1               5                   10                  15      


Met Ser Val Trp Thr Ser Pro Arg Arg Leu Val Glu Leu Ala Gly Gln 
            20                  25                  30          


Ser Leu Leu Lys Asp Glu Ala Leu Ala Ile Ala Ala Leu Glu Leu Leu 
        35                  40                  45              


Pro Arg Glu Leu Phe Pro Pro Leu Phe Met Ala Ala Phe Asp Gly Arg 
    50                  55                  60                  


His Ser Gln Thr Leu Lys Ala Met Val Gln Ala Trp Pro Phe Thr Cys 
65                  70                  75                  80  


Leu Pro Leu Gly Val Leu Met Lys Gly Gln His Leu His Leu Glu Thr 
                85                  90                  95      


Phe Lys Ala Val Leu Asp Gly Leu Asp Val Leu Leu Ala Gln Glu Val 
            100                 105                 110         


Arg Pro Arg Arg Trp Lys Leu Gln Val Leu Asp Leu Arg Lys Asn Ser 
        115                 120                 125             


His Gln Asp Phe Trp Thr Val Trp Ser Gly Asn Arg Ala Ser Leu Tyr 
    130                 135                 140                 


Ser Phe Pro Glu Pro Glu Ala Ala Gln Pro Met Thr Lys Lys Arg Lys 
145                 150                 155                 160 


Val Asp Gly Leu Ser Thr Glu Ala Glu Gln Pro Phe Ile Pro Val Glu 
                165                 170                 175     


Val Leu Val Asp Leu Phe Leu Lys Glu Gly Ala Cys Asp Glu Leu Phe 
            180                 185                 190         


Ser Tyr Leu Ile Glu Lys Val Lys Arg Lys Lys Asn Val Leu Arg Leu 
        195                 200                 205             


Cys Cys Lys Lys Leu Lys Ile Phe Ala Met Pro Met Gln Asp Ile Lys 
    210                 215                 220                 


Met Ile Leu Lys Met Val Gln Leu Asp Ser Ile Glu Asp Leu Glu Val 
225                 230                 235                 240 


Thr Cys Thr Trp Lys Leu Pro Thr Leu Ala Lys Phe Ser Pro Tyr Leu 
                245                 250                 255     


Gly Gln Met Ile Asn Leu Arg Arg Leu Leu Leu Ser His Ile His Ala 
            260                 265                 270         


Ser Ser Tyr Ile Ser Pro Glu Lys Glu Glu Gln Tyr Ile Ala Gln Phe 
        275                 280                 285             


Thr Ser Gln Phe Leu Ser Leu Gln Cys Leu Gln Ala Leu Tyr Val Asp 
    290                 295                 300                 


Ser Leu Phe Phe Leu Arg Gly Arg Leu Asp Gln Leu Leu Arg His Val 
305                 310                 315                 320 


Met Asn Pro Leu Glu Thr Leu Ser Ile Thr Asn Cys Arg Leu Ser Glu 
                325                 330                 335     


Gly Asp Val Met His Leu Ser Gln Ser Pro Ser Val Ser Gln Leu Ser 
            340                 345                 350         


Val Leu Ser Leu Ser Gly Val Met Leu Thr Asp Val Ser Pro Glu Pro 
        355                 360                 365             


Leu Gln Ala Leu Leu Glu Arg Ala Ser Ala Thr Leu Gln Asp Leu Val 
    370                 375                 380                 


Phe Asp Glu Cys Gly Ile Thr Asp Asp Gln Leu Leu Ala Leu Leu Pro 
385                 390                 395                 400 


Ser Leu Ser His Cys Ser Gln Leu Thr Thr Leu Ser Phe Tyr Gly Asn 
                405                 410                 415     


Ser Ile Ser Ile Ser Ala Leu Gln Ser Leu Leu Gln His Leu Ile Gly 
            420                 425                 430         


Leu Ser Asn Leu Thr His Val Leu Tyr Pro Val Pro Leu Glu Ser Tyr 
        435                 440                 445             


Glu Asp Ile His Gly Thr Leu His Leu Glu Arg Leu Ala Tyr Leu His 
    450                 455                 460                 


Ala Arg Leu Arg Glu Leu Leu Cys Glu Leu Gly Arg Pro Ser Met Val 
465                 470                 475                 480 


Trp Leu Ser Ala Asn Pro Cys Pro His Cys Gly Asp Arg Thr Phe Tyr 
                485                 490                 495     


Asp Pro Glu Pro Ile Leu Cys Pro Cys Phe Met Pro Asn 
            500                 505                 


<210>  843
<211>  509
<212>  PRT
<213>  Homo sapiens

<400>  843

Met Glu Arg Arg Arg Leu Arg Gly Ser Ile Gln Ser Arg Tyr Ile Ser 
1               5                   10                  15      


Met Ser Val Trp Thr Ser Pro Arg Arg Leu Val Glu Leu Ala Gly Gln 
            20                  25                  30          


Ser Leu Leu Lys Asp Glu Ala Leu Ala Ile Ala Ala Leu Glu Leu Leu 
        35                  40                  45              


Pro Arg Glu Leu Phe Pro Pro Leu Phe Met Ala Ala Phe Asp Gly Arg 
    50                  55                  60                  


His Ser Gln Thr Leu Lys Ala Met Val Gln Ala Trp Pro Phe Thr Cys 
65                  70                  75                  80  


Leu Pro Leu Gly Val Leu Met Lys Gly Gln His Leu His Leu Glu Thr 
                85                  90                  95      


Phe Lys Ala Val Leu Asp Gly Leu Asp Val Leu Leu Ala Gln Glu Val 
            100                 105                 110         


Arg Pro Arg Arg Trp Lys Leu Gln Val Leu Asp Leu Arg Lys Asn Ser 
        115                 120                 125             


His Gln Asp Phe Trp Thr Val Trp Ser Gly Asn Arg Ala Ser Leu Tyr 
    130                 135                 140                 


Ser Phe Pro Glu Pro Glu Ala Ala Gln Pro Met Thr Lys Lys Arg Lys 
145                 150                 155                 160 


Val Asp Gly Leu Ser Thr Glu Ala Glu Gln Pro Phe Ile Pro Val Glu 
                165                 170                 175     


Val Leu Val Asp Leu Phe Leu Lys Glu Gly Ala Cys Asp Glu Leu Phe 
            180                 185                 190         


Ser Tyr Leu Ile Glu Lys Val Lys Arg Lys Lys Asn Val Leu Arg Leu 
        195                 200                 205             


Cys Cys Lys Lys Leu Lys Ile Phe Ala Met Pro Met Gln Asp Ile Lys 
    210                 215                 220                 


Met Ile Leu Lys Met Val Gln Leu Asp Ser Ile Glu Asp Leu Glu Val 
225                 230                 235                 240 


Thr Cys Thr Trp Lys Leu Pro Thr Leu Ala Lys Phe Ser Pro Tyr Leu 
                245                 250                 255     


Gly Gln Met Ile Asn Leu Arg Arg Leu Leu Leu Ser His Ile His Ala 
            260                 265                 270         


Ser Ser Tyr Ile Ser Pro Glu Lys Glu Glu Gln Tyr Ile Ala Gln Phe 
        275                 280                 285             


Thr Ser Gln Phe Leu Ser Leu Gln Cys Leu Gln Ala Leu Tyr Val Asp 
    290                 295                 300                 


Ser Leu Phe Phe Leu Arg Gly Arg Leu Asp Gln Leu Leu Arg His Val 
305                 310                 315                 320 


Met Asn Pro Leu Glu Thr Leu Ser Ile Thr Asn Cys Arg Leu Ser Glu 
                325                 330                 335     


Gly Asp Val Met His Leu Ser Gln Ser Pro Ser Val Ser Gln Leu Ser 
            340                 345                 350         


Val Leu Ser Leu Ser Gly Val Met Leu Thr Asp Val Ser Pro Glu Pro 
        355                 360                 365             


Leu Gln Ala Leu Leu Glu Arg Ala Ser Ala Thr Leu Gln Asp Leu Val 
    370                 375                 380                 


Phe Asp Glu Cys Gly Ile Thr Asp Asp Gln Leu Leu Ala Leu Leu Pro 
385                 390                 395                 400 


Ser Leu Ser His Cys Ser Gln Leu Thr Thr Leu Ser Phe Tyr Gly Asn 
                405                 410                 415     


Ser Ile Ser Ile Ser Ala Leu Gln Ser Leu Leu Gln His Leu Ile Gly 
            420                 425                 430         


Leu Ser Asn Leu Thr His Val Leu Tyr Pro Val Pro Leu Glu Ser Tyr 
        435                 440                 445             


Glu Asp Ile His Gly Thr Leu His Leu Glu Arg Leu Ala Tyr Leu His 
    450                 455                 460                 


Ala Arg Leu Arg Glu Leu Leu Cys Glu Leu Gly Arg Pro Ser Met Val 
465                 470                 475                 480 


Trp Leu Ser Ala Asn Pro Cys Pro His Cys Gly Asp Arg Thr Phe Tyr 
                485                 490                 495     


Asp Pro Glu Pro Ile Leu Cys Pro Cys Phe Met Pro Asn 
            500                 505                 


<210>  844
<211>  3036
<212>  DNA
<213>  Homo sapiens

<400>  844
gctgggagca aagcgctgag ggagctcggt acgccgccgc ctcgcacccg cagcctcgcg       60

cccgccgccg cccgtcccca gagaaccatg gagtctggca gtaccgccgc cagtgaggag      120

gcacgcagcc ttcgagaatg tgagctctac gtccagaagc ataacattca agcgctgctc      180

aaagattcta ttgtgcagtt gtgcactgct cgacctgaga gacccatggc attcctcagg      240

gaatactttg agaggttgga gaaggaggag gcaaaacaga ttcagaatct gcagaaagca      300

ggcactcgta cagactcaag ggaggatgag atttctcctc ctccacccaa cccagtggtt      360

aaaggtagga ggcgacgagg tgctatcagc gctgaggtct acacggagga agatgcggca      420

tcctatgtta gaaaggttat accaaaagat tacaagacaa tggccgcttt agccaaagcc      480

attgaaaaga atgtgctgtt ttcacatctt gatgataatg agagaagtga tatttttgat      540

gccatgtttt cggtctcctt tatcgcagga gagactgtga ttcagcaagg tgatgaaggg      600

gataacttct atgtgattga tcaaggagag acggatgtct atgttaacaa tgaatgggca      660

accagtgttg gggaaggagg gagctttgga gaacttgctt tgatttatgg aacaccgaga      720

gcagccactg tcaaagcaaa gacaaatgtg aaattgtggg gcatcgaccg agacagctat      780

agaagaatcc tcatgggaag cacactgaga aagcggaaga tgtatgagga attccttagt      840

aaagtctcta ttttagagtc tctggacaag tgggaacgtc ttacggtagc tgatgcattg      900

gaaccagtgc agtttgaaga tgggcagaag attgtggtgc agggagaacc aggggatgag      960

ttcttcatta ttttagaggg gtcagctgct gtgctacaac gtcggtcaga aaatgaagag     1020

tttgttgaag tgggaagatt ggggccttct gattattttg gtgaaattgc actactgatg     1080

aatcgtcctc gtgctgccac agttgttgct cgtggcccct tgaagtgcgt taagctggac     1140

cgacctagat ttgaacgtgt tcttggccca tgctcagaca tcctcaaacg aaacatccag     1200

cagtacaaca gttttgtgtc actgtctgtc tgaaatctgc ctcctgtgcc tcccttttct     1260

cctctcccca atccatgctt cactcatgca aactgcttta ttttccctac ttgcagcgcc     1320

aagtggccac tggcatcgca gcttcctgtc tgtttatata ttgaaagttg cttttattgc     1380

accattttca atttggagca ttaactaaat gctcatacac agttaaataa atagaaagag     1440

ttctatggag actttgctgt tactgcttct ctttgtgcag tgttagtatt caccctgggc     1500

agtgagtgcc atgctttttg gtgagggcag atccagcacc tattgaatta ccatagagta     1560

atgatgtaac agtgcaagat tttttttttt aagtgacata attgtccagt tataagcgta     1620

tttagactgt ggccatatat gctgtatttc tttgtagaat aaatggtttc tcattaaact     1680

ctaaagatta gggaaatgga tatagaaaat cttagtatag tagaaagaca tctgcctgta     1740

attaaactag tttaagggtg gaaaaatgaa aatttttgct aattatcaat gggatatgat     1800

tggttcagtt ttttttttcc agagttgttg tttgccaagc taatctgcct ggtttattta     1860

tatcttgtta ttaatgtttc ttctccaatt ctgaaatact tttgagtatg gctatctata     1920

cctgcctttt aagtttgaaa ctaactcata gatgcaaata ttggttagta tttaactaca     1980

tctgcctcgg ctcacaaatt ccgattagac ctttatccag ctagtgccaa ataattgatc     2040

agatgctgaa ttgagaataa gaatttgagg tctacattct tggttgttaa tttagagcgt     2100

ttggttaaag tatgtccttc agctgactcc agtataatct cctctgctca ttaaactgat     2160

tccaggagat tggatttgct gtgactagat acagatggag caaatgtcct aacagagaaa     2220

tagaggtgat gctgctaaag ggagaaatgc caggcggaca aagttcagtg tcgggaattt     2280

tccccgtgac attcactggg gcatgagatt ttggaagaag ttttttactt tggtttagtc     2340

tttttttcct cctttttatt cagctagaat ttctggtggg ttgatggtag ggtataatgt     2400

gtctgtgttg cttcaaattg gtctgaaagg ctatcctgct gaaagtcctg ctttcctatc     2460

tagcatttat tcctctggca aacttttctt tcttttcttt tttaaagtaa acttgtgtat     2520

tgagtcttaa ctgtatttca gtattttcca gccttatgtg ttacattatt ccaatgatac     2580

ccaacagttt atttttatta tttttttaaa caaaatttca cagttctgta atgtaggcac     2640

ttttattttc attgtgattt atatataagg taatgtaggg ttatatttgg gagtgactgc     2700

aagcattttt ccatctgtgt gcaactaact gactctgtta ttgatccctt ctcctgccct     2760

ttcccaggta atttaaattg gtcatggtag atttttttca tagatttgaa aaacttttag     2820

gttgttacca agtatgaagt ataaatctgg ggaagaggtt ttatttacat tttagggtgg     2880

gtaagaaagc caccttgtta caaatttttt aatttccaaa ataatctata ttaaatgagg     2940

gtttctgatc tgtactttgt gtttagctac ctttttatat ttaaaaaatt aaaaatgaaa     3000

attatgttct tacaagctta aagcttgatt tgatct                               3036


<210>  845
<211>  381
<212>  PRT
<213>  Homo sapiens

<400>  845

Met Glu Ser Gly Ser Thr Ala Ala Ser Glu Glu Ala Arg Ser Leu Arg 
1               5                   10                  15      


Glu Cys Glu Leu Tyr Val Gln Lys His Asn Ile Gln Ala Leu Leu Lys 
            20                  25                  30          


Asp Ser Ile Val Gln Leu Cys Thr Ala Arg Pro Glu Arg Pro Met Ala 
        35                  40                  45              


Phe Leu Arg Glu Tyr Phe Glu Arg Leu Glu Lys Glu Glu Ala Lys Gln 
    50                  55                  60                  


Ile Gln Asn Leu Gln Lys Ala Gly Thr Arg Thr Asp Ser Arg Glu Asp 
65                  70                  75                  80  


Glu Ile Ser Pro Pro Pro Pro Asn Pro Val Val Lys Gly Arg Arg Arg 
                85                  90                  95      


Arg Gly Ala Ile Ser Ala Glu Val Tyr Thr Glu Glu Asp Ala Ala Ser 
            100                 105                 110         


Tyr Val Arg Lys Val Ile Pro Lys Asp Tyr Lys Thr Met Ala Ala Leu 
        115                 120                 125             


Ala Lys Ala Ile Glu Lys Asn Val Leu Phe Ser His Leu Asp Asp Asn 
    130                 135                 140                 


Glu Arg Ser Asp Ile Phe Asp Ala Met Phe Ser Val Ser Phe Ile Ala 
145                 150                 155                 160 


Gly Glu Thr Val Ile Gln Gln Gly Asp Glu Gly Asp Asn Phe Tyr Val 
                165                 170                 175     


Ile Asp Gln Gly Glu Thr Asp Val Tyr Val Asn Asn Glu Trp Ala Thr 
            180                 185                 190         


Ser Val Gly Glu Gly Gly Ser Phe Gly Glu Leu Ala Leu Ile Tyr Gly 
        195                 200                 205             


Thr Pro Arg Ala Ala Thr Val Lys Ala Lys Thr Asn Val Lys Leu Trp 
    210                 215                 220                 


Gly Ile Asp Arg Asp Ser Tyr Arg Arg Ile Leu Met Gly Ser Thr Leu 
225                 230                 235                 240 


Arg Lys Arg Lys Met Tyr Glu Glu Phe Leu Ser Lys Val Ser Ile Leu 
                245                 250                 255     


Glu Ser Leu Asp Lys Trp Glu Arg Leu Thr Val Ala Asp Ala Leu Glu 
            260                 265                 270         


Pro Val Gln Phe Glu Asp Gly Gln Lys Ile Val Val Gln Gly Glu Pro 
        275                 280                 285             


Gly Asp Glu Phe Phe Ile Ile Leu Glu Gly Ser Ala Ala Val Leu Gln 
    290                 295                 300                 


Arg Arg Ser Glu Asn Glu Glu Phe Val Glu Val Gly Arg Leu Gly Pro 
305                 310                 315                 320 


Ser Asp Tyr Phe Gly Glu Ile Ala Leu Leu Met Asn Arg Pro Arg Ala 
                325                 330                 335     


Ala Thr Val Val Ala Arg Gly Pro Leu Lys Cys Val Lys Leu Asp Arg 
            340                 345                 350         


Pro Arg Phe Glu Arg Val Leu Gly Pro Cys Ser Asp Ile Leu Lys Arg 
        355                 360                 365             


Asn Ile Gln Gln Tyr Asn Ser Phe Val Ser Leu Ser Val 
    370                 375                 380     


<210>  846
<211>  381
<212>  PRT
<213>  Homo sapiens

<400>  846

Met Glu Ser Gly Ser Thr Ala Ala Ser Glu Glu Ala Arg Ser Leu Arg 
1               5                   10                  15      


Glu Cys Glu Leu Tyr Val Gln Lys His Asn Ile Gln Ala Leu Leu Lys 
            20                  25                  30          


Asp Ser Ile Val Gln Leu Cys Thr Ala Arg Pro Glu Arg Pro Met Ala 
        35                  40                  45              


Phe Leu Arg Glu Tyr Phe Glu Arg Leu Glu Lys Glu Glu Ala Lys Gln 
    50                  55                  60                  


Ile Gln Asn Leu Gln Lys Ala Gly Thr Arg Thr Asp Ser Arg Glu Asp 
65                  70                  75                  80  


Glu Ile Ser Pro Pro Pro Pro Asn Pro Val Val Lys Gly Arg Arg Arg 
                85                  90                  95      


Arg Gly Ala Ile Ser Ala Glu Val Tyr Thr Glu Glu Asp Ala Ala Ser 
            100                 105                 110         


Tyr Val Arg Lys Val Ile Pro Lys Asp Tyr Lys Thr Met Ala Ala Leu 
        115                 120                 125             


Ala Lys Ala Ile Glu Lys Asn Val Leu Phe Ser His Leu Asp Asp Asn 
    130                 135                 140                 


Glu Arg Ser Asp Ile Phe Asp Ala Met Phe Ser Val Ser Phe Ile Ala 
145                 150                 155                 160 


Gly Glu Thr Val Ile Gln Gln Gly Asp Glu Gly Asp Asn Phe Tyr Val 
                165                 170                 175     


Ile Asp Gln Gly Glu Thr Asp Val Tyr Val Asn Asn Glu Trp Ala Thr 
            180                 185                 190         


Ser Val Gly Glu Gly Gly Ser Phe Gly Glu Leu Ala Leu Ile Tyr Gly 
        195                 200                 205             


Thr Pro Arg Ala Ala Thr Val Lys Ala Lys Thr Asn Val Lys Leu Trp 
    210                 215                 220                 


Gly Ile Asp Arg Asp Ser Tyr Arg Arg Ile Leu Met Gly Ser Thr Leu 
225                 230                 235                 240 


Arg Lys Arg Lys Met Tyr Glu Glu Phe Leu Ser Lys Val Ser Ile Leu 
                245                 250                 255     


Glu Ser Leu Asp Lys Trp Glu Arg Leu Thr Val Ala Asp Ala Leu Glu 
            260                 265                 270         


Pro Val Gln Phe Glu Asp Gly Gln Lys Ile Val Val Gln Gly Glu Pro 
        275                 280                 285             


Gly Asp Glu Phe Phe Ile Ile Leu Glu Gly Ser Ala Ala Val Leu Gln 
    290                 295                 300                 


Arg Arg Ser Glu Asn Glu Glu Phe Val Glu Val Gly Arg Leu Gly Pro 
305                 310                 315                 320 


Ser Asp Tyr Phe Gly Glu Ile Ala Leu Leu Met Asn Arg Pro Arg Ala 
                325                 330                 335     


Ala Thr Val Val Ala Arg Gly Pro Leu Lys Cys Val Lys Leu Asp Arg 
            340                 345                 350         


Pro Arg Phe Glu Arg Val Leu Gly Pro Cys Ser Asp Ile Leu Lys Arg 
        355                 360                 365             


Asn Ile Gln Gln Tyr Asn Ser Phe Val Ser Leu Ser Val 
    370                 375                 380     


<210>  847
<211>  8787
<212>  DNA
<213>  Homo sapiens

<400>  847
ggccgcagct ccccggcgga ggcaagaggt ggttgggggg gaccatggct gacgttttcc       60

cgggcaacga ctccacggcg tctcaggacg tggccaaccg cttcgcccgc aaaggggcgc      120

tgaggcagaa gaacgtgcac gaggtgaagg accacaaatt catcgcgcgc ttcttcaagc      180

agcccacctt ctgcagccac tgcaccgact tcatctgggg gtttgggaaa caaggcttcc      240

agtgccaagt ttgctgtttt gtggtccaca agaggtgcca tgaatttgtt actttttctt      300

gtccgggtgc ggataaggga cccgacactg atgaccccag gagcaagcac aagttcaaaa      360

tccacactta cggaagcccc accttctgcg atcactgtgg gtcactgctc tatggactta      420

tccatcaagg gatgaaatgt gacacctgcg atatgaacgt tcacaagcaa tgcgtcatca      480

atgtccccag cctctgcgga atggatcaca ctgagaagag ggggcggatt tacctaaagg      540

ctgaggttgc tgatgaaaag ctccatgtca cagtacgaga tgcaaaaaat ctaatcccta      600

tggatccaaa cgggctttca gatccttatg tgaagctgaa acttattcct gatcccaaga      660

atgaaagcaa gcaaaaaacc aaaaccatcc gctccacact aaatccgcag tggaatgagt      720

cctttacatt caaattgaaa ccttcagaca aagaccgacg actgtctgta gaaatctggg      780

actgggatcg aacaacaagg aatgacttca tgggatccct ttcctttgga gtttcggagc      840

tgatgaagat gccggccagt ggatggtaca agttgcttaa ccaagaagaa ggtgagtact      900

acaacgtacc cattccggaa ggggacgagg aaggaaacat ggaactcagg cagaaattcg      960

agaaagccaa acttggccct gctggcaaca aagtcatcag tccctctgaa gacaggaaac     1020

aaccttccaa caaccttgac cgagtgaaac tcacggactt caatttcctc atggtgttgg     1080

gaaaggggag ttttggaaag gtgatgcttg ccgacaggaa gggcacagaa gaactgtatg     1140

caatcaaaat cctgaagaag gatgtggtga ttcaggatga tgacgtggag tgcaccatgg     1200

tagaaaagcg agtcttggcc ctgcttgaca aacccccgtt cttgacgcag ctgcactcct     1260

gcttccagac agtggatcgg ctgtacttcg tcatggaata tgtcaacggt ggggacctca     1320

tgtaccacat tcagcaagta ggaaaattta aggaaccaca agcagtattc tatgcggcag     1380

agatttccat cggattgttc tttcttcata aaagaggaat catttatagg gatctgaagt     1440

tagataacgt catgttggat tcagaaggac atatcaaaat tgctgacttt gggatgtgca     1500

aggaacacat gatggatgga gtcacgacca ggaccttctg tgggactcca gattatatcg     1560

ccccagagat aatcgcttat cagccgtatg gaaaatctgt ggactggtgg gcctatggcg     1620

tcctgttgta tgaaatgctt gccgggcagc ctccatttga tggtgaagat gaagacgagc     1680

tatttcagtc tatcatggag cacaacgttt cctatccaaa atccttgtcc aaggaggctg     1740

tttctatctg caaaggactg atgaccaaac acccagccaa gcggctgggc tgtgggcctg     1800

agggggagag ggacgtgaga gagcatgcct tcttccggag gatcgactgg gaaaaactgg     1860

agaacaggga gatccagcca ccattcaagc ccaaagtgtg tggcaaagga gcagagaact     1920

ttgacaagtt cttcacacga ggacagcccg tcttaacacc acctgatcag ctggttattg     1980

ctaacataga ccagtctgat tttgaagggt tctcgtatgt caacccccag tttgtgcacc     2040

ccatcttaca gagtgcagta tgaaactcac cagcgagaac aaacacctcc ccagccccca     2100

gccctccccg cagtgggaag tgaatcctta accctaaaat tttaaggcca cggccttgtg     2160

tctgattcca tatggaggcc tgaaaattgt agggttatta gtccaaatgt gatcaactgt     2220

tcagggtctc tctcttacaa ccaagaacat tatcttagtg gaagatggta cgtcatgctc     2280

agtgtccagt ttaattctgt agaagttacg tctggctcta ggttaaccct tcctagaaag     2340

caagcagact gttgccccat tttgggtaca atttgatata ctttccatac cctccatctg     2400

tggatttttc agcattggaa tcccccaacc agagatgtta aagtgagcct gtcccaggaa     2460

acatctccac ccaagacgtc tttggaatcc aagaacagga agccaagaga gtgagcaggg     2520

agggattggg ggtgggggag gcctcaaaat accgactgcg tccattctct gcctccatgg     2580

aaacagcccc tagaatctga aaggccggga taaacctaat cactgttccc aaacattgac     2640

aaatcctaac ccaaccatgg tccagcagtt accagtttaa acaaaaaaac ctcagatgag     2700

tgttgggtga atctgtcatc tggtaccctc cttggttgat aactgtcttg atacttttca     2760

ttctttgtaa gaggccaaat cgtctaagga cgttgctgaa caagcgtgtg aaatcatttc     2820

agatcaagga taagccagtg tgtacatatg ttcattttaa tctctgggag attatttttc     2880

catccagggt gccatcagta atcatgccac tactcaccag tgttgttcgc caacacccac     2940

ccccacacac accaacattt tgctgcctac cttgttatcc ttctcaagaa gctgaagtgt     3000

acgccctctc cccttttgtg cttatttatt taataggctg cagtgtcgct tatgaaagta     3060

cgatgtacag taacttaatg gaagtgctga ctctagcatc agcctctacc gattgatttt     3120

cctcccttct ctagccctgg atgtccactt agggataaaa agaatatggt tttggttccc     3180

atttctagtt cacgttgaat gacaggcctg gagctgtaga atcaggaaac ccggatgcct     3240

aacagctcaa agatgttttg ttaatagaag gattttaata cgttttgcaa atgcatcatg     3300

caatgaattt tgcatgttta taataaacct taataacaag tgaatctata ttattgatat     3360

aatcgtatca agtataaaga gagtattata ataattttat aagacacaat tgtgctctat     3420

ttgtgcaggt tcttgtttct aatcctcttt tctaattaag ttttagctga atcccttgct     3480

tctgtgcttt ccctccctgc acatgggcac tgtatcagat agattacttt ttaaatgtag     3540

ataaaatttc aaaaatgaat ggctagttta cgtgatagat taggctctta ctacatatgt     3600

gtgtgtatat atatgtattt gattctacct gcaaacaaat ttttattggt gaggactatt     3660

tttgagctga cactccctct tagtttcttc atgtcacctt tcgtcctggt tcctccgcca     3720

ctcttcctct tggggacaac aggaagtgtc tgattccagt ctgcctagta cgttggtaca     3780

cacgtggcat tgccgcagca cctgggctga cctttgtgtg tgcgtgtgtg tgtgtttcct     3840

tcttcccttc agcctgtgac tgttgctgac tccaggggtg ggagggatgg ggagactccc     3900

ctcttgctgt gtgtactgga cacgcaggaa gcatgctgtc ttgctgcctc tgcaacgacc     3960

tgtcgtttgc tccagcatgc acaaacttcg tgagaccaac acagccgtgc cctgcaggca     4020

ccagcacgtg cttttcagag gctgcggact ttcttccagc cattgtggca ttggcctttc     4080

cagtcttggg aggagcgcgc tgctttggtg agacaccccc atgcaaggtc ctcagagtag     4140

ccgggttcta ccacaaacag aaacagaatg aaagtagctg tcagtccttg tagagagccg     4200

ctctgtttcc tcccagaagc atctcccagc taagctcgca ttatttttct cctctggctg     4260

tttgcctgaa gttcacagaa cacacaacca tgaaaggctt tttgaggtga gaggcccagg     4320

tggtcctggc aaccctgagt agaaggagag acggggtagg gaacgggccc ggccagaaaa     4380

gaaccatttc ttctgccatc ttttatgcac catagacatc gagactccag ggggtcctgg     4440

ctcccctgtc cctgcagccc tgcaggtcag tgcatgatct gggttcgtgt cctgaccagg     4500

tgctcctcct ttgatccgag gggaaaggga ctggtttata gaaagagcct aggagacaaa     4560

agggccagtc cccctgccca gaatggagca gcagcaggac agacccccac gaggcccccc     4620

agagaggagg aagatcccac ggaggaacac atgaggttag ggacccttgt tcagcacccc     4680

aaacagcctg cctgtttaaa gcaggcagca ggcttaggcc ttccctgcaa ccccaacacc     4740

cacaagtttg tttctctagg aaacacattc actgtctcag ctggctgtta ctctctcaga     4800

ccatatggca aagttttcca agaaaatgcc ccgacagggg tgcccagcac actgcctgag     4860

ggacaacaga catcagaaca aacccccaga gagaaacagt caaaatcagg gcccggtgca     4920

gtgttgtcat gtggaacctg ctttatccat tgctgagtgt tgaatgtggg taatggttag     4980

ggctttccag atctcagcag ccaaagacag ttattgttgg aagactgtca tgtagataac     5040

catgagcaat ggctcgcctc agaatcagtt cataaaattc tatggtactg gccccttcgt     5100

gggtattgtg tgaaatgaga tggtggcgag gggtgcgctg tggaactgcc gcagccacgc     5160

aggaggtccc tgggggatgc tttgggaagt ccttgcccct gagcactgcc tgattgccag     5220

ggcctgtgga ggtctaggcc gcctggcaga atctagcacc gtccgaatcc ccgcaggacc     5280

catggagcta tgaccacacc aggccattca aatggctctg cattatcttc ccttggaagg     5340

tggccactcc tcggtggcag ggcctttccc tgaggctgca ggccgtgggc tggcagcccg     5400

tctcttggca tttcaattga aggtcaccag gtgctgggtt tgaaaggaag tcactggagt     5460

gctgccaggg gccgccctcc aaggttaatg agaggcccac atccaggcaa gaactaattc     5520

aaaaggcaga tcagaaacca caggagtcaa aattattgct ccggcagtgc ttcccttcct     5580

ttcatccact ggcctcgtgt ggtccatgca gggccactgt ctgccctttc tgatgccacg     5640

tattaggctt tcttactcag aattttgata gaaaaccatg gggccaagag ctctggaagc     5700

ctggccggaa agaccaaggt tcatgcagcc caacaaatga ttgttgagca cctctcggag     5760

ccaaagtcct taggcgagtg tggtgacttc ctggaaggag gatgcagact tccagagagc     5820

ccccccaacg gacgtgctga gaagggagag ggaggcgggg gctgtagtca ggaaggagcc     5880

agagaagaac agggtttggg tgcatccaga aatatgcctg cagtaggagg gagaggaagg     5940

ggtgccaccg tcaacggctt cccatcggag gtggttggtg cagatggaag tttctgtctg     6000

ctggccctca agagagtgtt ttgccaggga cacagtctgt tcctcctcag aaaacacccc     6060

ccaaatgcta acaacatccc caccagctgc tagaagcccc tttcccctcc ccaccttgaa     6120

gtagctcata gttctctggg cagagccaga ccatccagtg taccccagag gccagtaggt     6180

tcctgcccat tttcctctct ggcttcctgc caagaattat ggcagctgag gatgaatgga     6240

gaagtaaaaa caactaacac cgcacaacta acaactaaca ccgcagttcc cacctgggtt     6300

ccacttagca ggagacattt cggagggttt tttttgtttt tgttcctgtt tttttttttt     6360

ttgctggaat ttgttttctc agtactgaaa agagaaaaag tgacaatctt gtatttttaa     6420

aagcctcgga aaggtgatac catctgacag tcattttctc acgttggtct tctaaagtca     6480

cctatttctt gtgtgtgcac atcacaccat ttcctgtttc tttataaccc gacaagggta     6540

ggagtgcctg tttcccctgc tgggcacacc agacaatcgt aatcacaaaa cagacactga     6600

gccaggggcc caaagggtgt gatcatgaga gttaccggga cagcagtagg catgacagtc     6660

accaggaagg acaagggtgc tctgttgtta gtggccacac accaatttga caaggagtgt     6720

tgcgaaattt ttatttattt atttatttat tttgagatgg agtttcactc ttgttgccca     6780

ggctggagtg cggtggtaca atctcggctc actgcaacct ccacctccca ggttcaagcg     6840

attctcctgc ctcagcctcc caagtacctg ggactacagg tgcgtgccac cacacccagc     6900

taaattttgt gtttttagta gagatggggt ttcaccatgt tggccaggat ggtcttgaac     6960

ccctgacctc atgatctgcc tgcctcggcc tcccaaagtg ctgggattac aggcatgagc     7020

caccacgccc agccaaaata tttttttaaa gtcattttcc ttaagctgct tgggctacat     7080

gtgaaataca ctggacggtc aacattcctg tctcctccca tttgggctga tgcagcagat     7140

ccagggaatg ttacctgttt ctgctgctag aagatccagg aaattgggaa ggttacctga     7200

cgcacacatg gatgaaggcc atcatctaga aatggggtca accacaattg tgttaattcc     7260

gtagtgtcag ggattcttcg ggaaggtcaa cagtatgaag gattctgacc cctgtgcctc     7320

ccatttatgt gatcaggtga cagttaataa ccgtggaggt cacactcagc catccaacag     7380

ccttacagtg accctacaca aaagccccca aattccaaag actttttctt aacctaaagg     7440

aagaaattat ttgttaattc cagtagagca actgaatata ctgggctatt tgtacttttt     7500

tatagagaac tttaataata attctttaaa aatgagtttt tagaacaaag caactgacga     7560

tttcctaaga ttccaatgcc ctggagcttg taggaggact tagcctgggt cagctggagc     7620

acccccgacc tgatctccca ctgccagatt ttcccatgct cctagggtat ggagtccacg     7680

tgggaatgac tgcaagttca ggtggaactt ggccgactga tgctctgcga gtttttaata     7740

gacactgggg acaactgctt aaggtttaga aacttccaaa ccacaggaaa gacattttta     7800

gtgtccccca tccagaggca gccctggaat aggattccca ggggtttctg ggaccccttt     7860

ccttgctccg tgaggctctg tggccatctt ttggcaggag gaggatgctt ccttggctct     7920

gtgcccagac ccgcctggtc cccaggtctc tcaccttggg tgaagattca gagatgccct     7980

gtaaggattt tgcccactgg gcaactcaga aatacttcga tctcccaaga tataagaggc     8040

agcagcaaac gtgcctattg acgtctgttt catagttacc acttacgcga gtagacagaa     8100

ctcggctttt cagaaaatag gtgtcaagtc cactttataa gaaccttttt ttctaaaata     8160

agataaaagg tggctttgca ttttctgatt aaacgactgt gtctttgtca cctctgctta     8220

actttaggag tatccattcc tgtgattgta gacttttgtt gatattcttc ctggaagaat     8280

atcattcttt tcttgaaggg ttggtttact agaatattca aaatcaatca tgaaggcagt     8340

tactattttg agtctaaagg ttttctaaaa attaacctca catcccttct gttagggtct     8400

ttcagaatat cttttataaa cagaagcatt tgaagtcatt gcttttgcta catgatttgt     8460

gtgtgtgaag gacataccac gtttaaatca ttaattgaaa aacatcatat aagccccaac     8520

tttgtttgga ggaagagacg gaggttgagg tttttccttc tgtataagca cctactgaca     8580

aaatgtagag gccattcaac cgtcaaacac catttggtta tatcgcagag gagacggatg     8640

tgtaaattac tgcattgctt tttttttcag tttgtataac ctctaatctc cgtttgcatg     8700

atacgctttg ttagaaacat taattgtagt ttggaagcaa gtgtgtatga ataaagataa     8760

tgatcattcc aaaaaaaaaa aaaaaaa                                         8787


<210>  848
<211>  672
<212>  PRT
<213>  Homo sapiens

<400>  848

Met Ala Asp Val Phe Pro Gly Asn Asp Ser Thr Ala Ser Gln Asp Val 
1               5                   10                  15      


Ala Asn Arg Phe Ala Arg Lys Gly Ala Leu Arg Gln Lys Asn Val His 
            20                  25                  30          


Glu Val Lys Asp His Lys Phe Ile Ala Arg Phe Phe Lys Gln Pro Thr 
        35                  40                  45              


Phe Cys Ser His Cys Thr Asp Phe Ile Trp Gly Phe Gly Lys Gln Gly 
    50                  55                  60                  


Phe Gln Cys Gln Val Cys Cys Phe Val Val His Lys Arg Cys His Glu 
65                  70                  75                  80  


Phe Val Thr Phe Ser Cys Pro Gly Ala Asp Lys Gly Pro Asp Thr Asp 
                85                  90                  95      


Asp Pro Arg Ser Lys His Lys Phe Lys Ile His Thr Tyr Gly Ser Pro 
            100                 105                 110         


Thr Phe Cys Asp His Cys Gly Ser Leu Leu Tyr Gly Leu Ile His Gln 
        115                 120                 125             


Gly Met Lys Cys Asp Thr Cys Asp Met Asn Val His Lys Gln Cys Val 
    130                 135                 140                 


Ile Asn Val Pro Ser Leu Cys Gly Met Asp His Thr Glu Lys Arg Gly 
145                 150                 155                 160 


Arg Ile Tyr Leu Lys Ala Glu Val Ala Asp Glu Lys Leu His Val Thr 
                165                 170                 175     


Val Arg Asp Ala Lys Asn Leu Ile Pro Met Asp Pro Asn Gly Leu Ser 
            180                 185                 190         


Asp Pro Tyr Val Lys Leu Lys Leu Ile Pro Asp Pro Lys Asn Glu Ser 
        195                 200                 205             


Lys Gln Lys Thr Lys Thr Ile Arg Ser Thr Leu Asn Pro Gln Trp Asn 
    210                 215                 220                 


Glu Ser Phe Thr Phe Lys Leu Lys Pro Ser Asp Lys Asp Arg Arg Leu 
225                 230                 235                 240 


Ser Val Glu Ile Trp Asp Trp Asp Arg Thr Thr Arg Asn Asp Phe Met 
                245                 250                 255     


Gly Ser Leu Ser Phe Gly Val Ser Glu Leu Met Lys Met Pro Ala Ser 
            260                 265                 270         


Gly Trp Tyr Lys Leu Leu Asn Gln Glu Glu Gly Glu Tyr Tyr Asn Val 
        275                 280                 285             


Pro Ile Pro Glu Gly Asp Glu Glu Gly Asn Met Glu Leu Arg Gln Lys 
    290                 295                 300                 


Phe Glu Lys Ala Lys Leu Gly Pro Ala Gly Asn Lys Val Ile Ser Pro 
305                 310                 315                 320 


Ser Glu Asp Arg Lys Gln Pro Ser Asn Asn Leu Asp Arg Val Lys Leu 
                325                 330                 335     


Thr Asp Phe Asn Phe Leu Met Val Leu Gly Lys Gly Ser Phe Gly Lys 
            340                 345                 350         


Val Met Leu Ala Asp Arg Lys Gly Thr Glu Glu Leu Tyr Ala Ile Lys 
        355                 360                 365             


Ile Leu Lys Lys Asp Val Val Ile Gln Asp Asp Asp Val Glu Cys Thr 
    370                 375                 380                 


Met Val Glu Lys Arg Val Leu Ala Leu Leu Asp Lys Pro Pro Phe Leu 
385                 390                 395                 400 


Thr Gln Leu His Ser Cys Phe Gln Thr Val Asp Arg Leu Tyr Phe Val 
                405                 410                 415     


Met Glu Tyr Val Asn Gly Gly Asp Leu Met Tyr His Ile Gln Gln Val 
            420                 425                 430         


Gly Lys Phe Lys Glu Pro Gln Ala Val Phe Tyr Ala Ala Glu Ile Ser 
        435                 440                 445             


Ile Gly Leu Phe Phe Leu His Lys Arg Gly Ile Ile Tyr Arg Asp Leu 
    450                 455                 460                 


Lys Leu Asp Asn Val Met Leu Asp Ser Glu Gly His Ile Lys Ile Ala 
465                 470                 475                 480 


Asp Phe Gly Met Cys Lys Glu His Met Met Asp Gly Val Thr Thr Arg 
                485                 490                 495     


Thr Phe Cys Gly Thr Pro Asp Tyr Ile Ala Pro Glu Ile Ile Ala Tyr 
            500                 505                 510         


Gln Pro Tyr Gly Lys Ser Val Asp Trp Trp Ala Tyr Gly Val Leu Leu 
        515                 520                 525             


Tyr Glu Met Leu Ala Gly Gln Pro Pro Phe Asp Gly Glu Asp Glu Asp 
    530                 535                 540                 


Glu Leu Phe Gln Ser Ile Met Glu His Asn Val Ser Tyr Pro Lys Ser 
545                 550                 555                 560 


Leu Ser Lys Glu Ala Val Ser Ile Cys Lys Gly Leu Met Thr Lys His 
                565                 570                 575     


Pro Ala Lys Arg Leu Gly Cys Gly Pro Glu Gly Glu Arg Asp Val Arg 
            580                 585                 590         


Glu His Ala Phe Phe Arg Arg Ile Asp Trp Glu Lys Leu Glu Asn Arg 
        595                 600                 605             


Glu Ile Gln Pro Pro Phe Lys Pro Lys Val Cys Gly Lys Gly Ala Glu 
    610                 615                 620                 


Asn Phe Asp Lys Phe Phe Thr Arg Gly Gln Pro Val Leu Thr Pro Pro 
625                 630                 635                 640 


Asp Gln Leu Val Ile Ala Asn Ile Asp Gln Ser Asp Phe Glu Gly Phe 
                645                 650                 655     


Ser Tyr Val Asn Pro Gln Phe Val His Pro Ile Leu Gln Ser Ala Val 
            660                 665                 670         


<210>  849
<211>  672
<212>  PRT
<213>  Homo sapiens

<400>  849

Met Ala Asp Val Tyr Pro Gly Asn Asp Ser Thr Ala Ser Gln Asp Val 
1               5                   10                  15      


Ala Asn Arg Phe Ala Arg Lys Gly Ala Leu Arg Gln Lys Asn Val His 
            20                  25                  30          


Glu Val Lys Asp His Lys Phe Ile Ala Arg Phe Phe Lys Gln Pro Thr 
        35                  40                  45              


Phe Cys Ser His Cys Thr Asp Phe Ile Trp Gly Phe Gly Lys Gln Gly 
    50                  55                  60                  


Phe Gln Cys Gln Val Cys Cys Phe Val Val His Lys Arg Cys His Glu 
65                  70                  75                  80  


Phe Val Thr Phe Ser Cys Pro Gly Ala Asp Lys Gly Pro Asp Thr Asp 
                85                  90                  95      


Asp Pro Arg Ser Lys His Lys Phe Lys Ile His Thr Tyr Gly Ser Pro 
            100                 105                 110         


Thr Phe Cys Asp His Cys Gly Ser Leu Leu Tyr Gly Leu Ile His Gln 
        115                 120                 125             


Gly Met Lys Cys Asp Thr Cys Asp Met Asn Val His Lys Gln Cys Val 
    130                 135                 140                 


Ile Asn Val Pro Ser Leu Cys Gly Met Asp His Thr Glu Lys Arg Gly 
145                 150                 155                 160 


Arg Ile Tyr Leu Lys Ala Glu Val Ala Asp Glu Lys Leu His Val Thr 
                165                 170                 175     


Val Arg Asp Ala Lys Asn Leu Ile Pro Met Asp Pro Asn Gly Leu Ser 
            180                 185                 190         


Asp Pro Tyr Val Lys Leu Lys Leu Ile Pro Asp Pro Lys Asn Glu Ser 
        195                 200                 205             


Lys Gln Lys Thr Lys Thr Ile Arg Ser Thr Leu Asn Pro Gln Trp Asn 
    210                 215                 220                 


Glu Ser Phe Thr Phe Lys Leu Lys Pro Ser Asp Lys Asp Arg Arg Leu 
225                 230                 235                 240 


Ser Val Glu Ile Trp Asp Trp Asp Arg Thr Thr Arg Asn Asp Phe Met 
                245                 250                 255     


Gly Ser Leu Ser Phe Gly Val Ser Glu Leu Met Lys Met Pro Ala Ser 
            260                 265                 270         


Gly Trp Tyr Lys Leu Leu Asn Gln Glu Glu Gly Glu Tyr Tyr Asn Val 
        275                 280                 285             


Pro Ile Pro Glu Gly Asp Glu Glu Gly Asn Met Glu Leu Arg Gln Lys 
    290                 295                 300                 


Phe Glu Lys Ala Lys Leu Gly Pro Ala Gly Asn Lys Val Ile Ser Pro 
305                 310                 315                 320 


Ser Glu Asp Arg Lys Gln Pro Ser Asn Asn Leu Asp Arg Val Lys Leu 
                325                 330                 335     


Thr Asp Phe Asn Phe Leu Met Val Leu Gly Lys Gly Ser Phe Gly Lys 
            340                 345                 350         


Val Met Leu Ala Asp Arg Lys Gly Thr Glu Glu Leu Tyr Ala Ile Lys 
        355                 360                 365             


Ile Leu Lys Lys Asp Val Val Ile Gln Asp Asp Asp Val Glu Cys Thr 
    370                 375                 380                 


Met Val Glu Lys Arg Val Leu Ala Leu Leu Asp Lys Pro Pro Phe Leu 
385                 390                 395                 400 


Thr Gln Leu His Ser Cys Phe Gln Thr Val Asp Arg Leu Tyr Phe Val 
                405                 410                 415     


Met Glu Tyr Val Asn Gly Gly Asp Leu Met Tyr His Ile Gln Gln Val 
            420                 425                 430         


Gly Lys Phe Lys Glu Pro Gln Ala Val Phe Tyr Ala Ala Glu Ile Ser 
        435                 440                 445             


Ile Gly Leu Phe Phe Leu His Lys Arg Gly Ile Ile Tyr Arg Asp Leu 
    450                 455                 460                 


Lys Leu Asp Asn Val Met Leu Asp Ser Glu Gly His Ile Lys Ile Ala 
465                 470                 475                 480 


Asp Phe Gly Met Cys Lys Glu His Met Met Asp Gly Val Thr Thr Arg 
                485                 490                 495     


Thr Phe Cys Gly Thr Pro Asp Tyr Ile Ala Pro Glu Ile Ile Ala Tyr 
            500                 505                 510         


Gln Pro Tyr Gly Lys Ser Val Asp Trp Trp Ala Tyr Gly Val Leu Leu 
        515                 520                 525             


Tyr Glu Met Leu Ala Gly Gln Pro Pro Phe Asp Gly Glu Asp Glu Asp 
    530                 535                 540                 


Glu Leu Phe Gln Ser Ile Met Glu His Asn Val Ser Tyr Pro Lys Ser 
545                 550                 555                 560 


Leu Ser Lys Glu Ala Val Ser Ile Cys Lys Gly Leu Met Thr Lys His 
                565                 570                 575     


Pro Ala Lys Arg Leu Gly Cys Gly Pro Glu Gly Glu Arg Asp Val Arg 
            580                 585                 590         


Glu His Ala Phe Phe Arg Gly Ile Asp Trp Glu Lys Leu Glu Asn Arg 
        595                 600                 605             


Glu Ile Gln Pro Pro Phe Lys Pro Lys Val Cys Gly Lys Gly Ala Glu 
    610                 615                 620                 


Asn Phe Asp Lys Phe Phe Thr Arg Gly Gln Pro Val Leu Thr Pro Pro 
625                 630                 635                 640 


Asp Gln Leu Val Ile Ala Asn Ile Asp Gln Ser Asp Phe Glu Gly Phe 
                645                 650                 655     


Ser Tyr Val Asn Pro Gln Phe Val His Pro Ile Leu Gln Ser Ala Val 
            660                 665                 670         


<210>  850
<211>  2711
<212>  DNA
<213>  Homo sapiens

<400>  850
agctggacga gcggcagcag ctgggcgagt gacagccccg gctccgcgcg ccgcggccgc       60

cagagccggc gcaggggaag cgcccgcggc cccgggtgca gcagcggccg ccgcctcccg      120

cgcctccccg gcccgcagcc cgcggtcccg cggccccggg gccggcacct ctcgggctcc      180

ggctccccgc gcgcaagatg gctgacccgg ctgcggggcc gccgccgagc gagggcgagg      240

agagcaccgt gcgcttcgcc cgcaaaggcg ccctccggca gaagaacgtg catgaggtca      300

agaaccacaa attcaccgcc cgcttcttca agcagcccac cttctgcagc cactgcaccg      360

acttcatctg gggcttcggg aagcagggat tccagtgcca agtttgctgc tttgtggtgc      420

acaagcggtg ccatgaattt gtcacattct cctgccctgg cgctgacaag ggtccagcct      480

ccgatgaccc ccgcagcaaa cacaagttta agatccacac gtactccagc cccacgtttt      540

gtgaccactg tgggtcactg ctgtatggac tcatccacca ggggatgaaa tgtgacacct      600

gcatgatgaa tgtgcacaag cgctgcgtga tgaatgttcc cagcctgtgt ggcacggacc      660

acacggagcg ccgcggccgc atctacatcc aggcccacat cgacagggac gtcctcattg      720

tcctcgtaag agatgctaaa aaccttgtac ctatggaccc caatggcctg tcagatccct      780

acgtaaaact gaaactgatt cccgatccca aaagtgagag caaacagaag accaaaacca      840

tcaaatgctc cctcaaccct gagtggaatg agacatttag atttcagctg aaagaatcgg      900

acaaagacag aagactgtca gtagagattt gggattggga tttgaccagc aggaatgact      960

tcatgggatc tttgtccttt gggatttctg aacttcagaa agccagtgtt gatggctggt     1020

ttaagttact gagccaggag gaaggcgagt acttcaatgt gcctgtgcca ccagaaggaa     1080

gtgaggccaa tgaagaactg cggcagaaat ttgagagggc caagatcagt cagggaacca     1140

aggtcccgga agaaaagacg accaacactg tctccaaatt tgacaacaat ggcaacagag     1200

accggatgaa actgaccgat tttaacttcc taatggtgct ggggaaaggc agctttggca     1260

aggtcatgct ttcagaacga aaaggcacag atgagctcta tgctgtgaag atcctgaaga     1320

aggacgttgt gatccaagat gatgacgtgg agtgcactat ggtggagaag cgggtgttgg     1380

ccctgcctgg gaagccgccc ttcctgaccc agctccactc ctgcttccag accatggacc     1440

gcctgtactt tgtgatggag tacgtgaatg ggggcgacct catgtatcac atccagcaag     1500

tcggccggtt caaggagccc catgctgtat tttacgctgc agaaattgcc atcggtctgt     1560

tcttcttaca gagtaagggc atcatttacc gtgacctaaa acttgacaac gtgatgctcg     1620

attctgaggg acacatcaag attgccgatt ttggcatgtg taaggaaaac atctgggatg     1680

gggtgacaac caagacattc tgtggcactc cagactacat cgcccccgag ataattgctt     1740

atcagcccta tgggaagtcc gtggattggt gggcatttgg agtcctgctg tatgaaatgt     1800

tggctgggca ggcacccttt gaaggggagg atgaagatga actcttccaa tccatcatgg     1860

aacacaacgt agcctatccc aagtctatgt ccaaggaagc tgtggccatc tgcaaagggc     1920

tgatgaccaa acacccaggc aaacgtctgg gttgtggacc tgaaggcgaa cgtgatatca     1980

aagagcatgc atttttccgg tatattgatt gggagaaact tgaacgcaaa gagatccagc     2040

ccccttataa gccaaaagct agagacaaga gagacacctc caacttcgac aaagagttca     2100

ccagacagcc tgtggaactg acccccactg ataaactctt catcatgaac ttggaccaaa     2160

atgaatttgc tggcttctct tatactaacc cagagtttgt cattaatgtg taggtgaatg     2220

caaactccat cgttgagcct ggggtgtaag acttcaagcc aagcgtatgt atcaattcta     2280

gtcttccagg attcacggtg cacatgctgg cattcaacat gtggaaagct tgtcttagag     2340

ggcttttctt tgtatgtgta gcttgctagt ttgttttcta catttgaaaa tgtttagttt     2400

agaataagcg cattatccaa ttatagaggt acaattttcc aaacttccag aaactcatca     2460

aatgaacaga caatgtcaaa actactgtgt ctgataccaa aatgcttcag tatttgtaat     2520

ttttcaagtc agaagctgat gttcctggta aaagttttta cagttattct ataatatctt     2580

ctttgaatgc taagcatgag cgatattttt aaaaattgtg agtaagcttt gcagttactg     2640

tgaactattg tctcttggag gaagtttttt gtttaagaat tgatatgatt aaactgaatt     2700

aatatatgca a                                                          2711


<210>  851
<211>  671
<212>  PRT
<213>  Homo sapiens

<400>  851

Met Ala Asp Pro Ala Ala Gly Pro Pro Pro Ser Glu Gly Glu Glu Ser 
1               5                   10                  15      


Thr Val Arg Phe Ala Arg Lys Gly Ala Leu Arg Gln Lys Asn Val His 
            20                  25                  30          


Glu Val Lys Asn His Lys Phe Thr Ala Arg Phe Phe Lys Gln Pro Thr 
        35                  40                  45              


Phe Cys Ser His Cys Thr Asp Phe Ile Trp Gly Phe Gly Lys Gln Gly 
    50                  55                  60                  


Phe Gln Cys Gln Val Cys Cys Phe Val Val His Lys Arg Cys His Glu 
65                  70                  75                  80  


Phe Val Thr Phe Ser Cys Pro Gly Ala Asp Lys Gly Pro Ala Ser Asp 
                85                  90                  95      


Asp Pro Arg Ser Lys His Lys Phe Lys Ile His Thr Tyr Ser Ser Pro 
            100                 105                 110         


Thr Phe Cys Asp His Cys Gly Ser Leu Leu Tyr Gly Leu Ile His Gln 
        115                 120                 125             


Gly Met Lys Cys Asp Thr Cys Met Met Asn Val His Lys Arg Cys Val 
    130                 135                 140                 


Met Asn Val Pro Ser Leu Cys Gly Thr Asp His Thr Glu Arg Arg Gly 
145                 150                 155                 160 


Arg Ile Tyr Ile Gln Ala His Ile Asp Arg Asp Val Leu Ile Val Leu 
                165                 170                 175     


Val Arg Asp Ala Lys Asn Leu Val Pro Met Asp Pro Asn Gly Leu Ser 
            180                 185                 190         


Asp Pro Tyr Val Lys Leu Lys Leu Ile Pro Asp Pro Lys Ser Glu Ser 
        195                 200                 205             


Lys Gln Lys Thr Lys Thr Ile Lys Cys Ser Leu Asn Pro Glu Trp Asn 
    210                 215                 220                 


Glu Thr Phe Arg Phe Gln Leu Lys Glu Ser Asp Lys Asp Arg Arg Leu 
225                 230                 235                 240 


Ser Val Glu Ile Trp Asp Trp Asp Leu Thr Ser Arg Asn Asp Phe Met 
                245                 250                 255     


Gly Ser Leu Ser Phe Gly Ile Ser Glu Leu Gln Lys Ala Ser Val Asp 
            260                 265                 270         


Gly Trp Phe Lys Leu Leu Ser Gln Glu Glu Gly Glu Tyr Phe Asn Val 
        275                 280                 285             


Pro Val Pro Pro Glu Gly Ser Glu Ala Asn Glu Glu Leu Arg Gln Lys 
    290                 295                 300                 


Phe Glu Arg Ala Lys Ile Ser Gln Gly Thr Lys Val Pro Glu Glu Lys 
305                 310                 315                 320 


Thr Thr Asn Thr Val Ser Lys Phe Asp Asn Asn Gly Asn Arg Asp Arg 
                325                 330                 335     


Met Lys Leu Thr Asp Phe Asn Phe Leu Met Val Leu Gly Lys Gly Ser 
            340                 345                 350         


Phe Gly Lys Val Met Leu Ser Glu Arg Lys Gly Thr Asp Glu Leu Tyr 
        355                 360                 365             


Ala Val Lys Ile Leu Lys Lys Asp Val Val Ile Gln Asp Asp Asp Val 
    370                 375                 380                 


Glu Cys Thr Met Val Glu Lys Arg Val Leu Ala Leu Pro Gly Lys Pro 
385                 390                 395                 400 


Pro Phe Leu Thr Gln Leu His Ser Cys Phe Gln Thr Met Asp Arg Leu 
                405                 410                 415     


Tyr Phe Val Met Glu Tyr Val Asn Gly Gly Asp Leu Met Tyr His Ile 
            420                 425                 430         


Gln Gln Val Gly Arg Phe Lys Glu Pro His Ala Val Phe Tyr Ala Ala 
        435                 440                 445             


Glu Ile Ala Ile Gly Leu Phe Phe Leu Gln Ser Lys Gly Ile Ile Tyr 
    450                 455                 460                 


Arg Asp Leu Lys Leu Asp Asn Val Met Leu Asp Ser Glu Gly His Ile 
465                 470                 475                 480 


Lys Ile Ala Asp Phe Gly Met Cys Lys Glu Asn Ile Trp Asp Gly Val 
                485                 490                 495     


Thr Thr Lys Thr Phe Cys Gly Thr Pro Asp Tyr Ile Ala Pro Glu Ile 
            500                 505                 510         


Ile Ala Tyr Gln Pro Tyr Gly Lys Ser Val Asp Trp Trp Ala Phe Gly 
        515                 520                 525             


Val Leu Leu Tyr Glu Met Leu Ala Gly Gln Ala Pro Phe Glu Gly Glu 
    530                 535                 540                 


Asp Glu Asp Glu Leu Phe Gln Ser Ile Met Glu His Asn Val Ala Tyr 
545                 550                 555                 560 


Pro Lys Ser Met Ser Lys Glu Ala Val Ala Ile Cys Lys Gly Leu Met 
                565                 570                 575     


Thr Lys His Pro Gly Lys Arg Leu Gly Cys Gly Pro Glu Gly Glu Arg 
            580                 585                 590         


Asp Ile Lys Glu His Ala Phe Phe Arg Tyr Ile Asp Trp Glu Lys Leu 
        595                 600                 605             


Glu Arg Lys Glu Ile Gln Pro Pro Tyr Lys Pro Lys Ala Arg Asp Lys 
    610                 615                 620                 


Arg Asp Thr Ser Asn Phe Asp Lys Glu Phe Thr Arg Gln Pro Val Glu 
625                 630                 635                 640 


Leu Thr Pro Thr Asp Lys Leu Phe Ile Met Asn Leu Asp Gln Asn Glu 
                645                 650                 655     


Phe Ala Gly Phe Ser Tyr Thr Asn Pro Glu Phe Val Ile Asn Val 
            660                 665                 670     


<210>  852
<211>  671
<212>  PRT
<213>  Homo sapiens

<400>  852

Met Ala Asp Pro Ala Ala Gly Pro Pro Pro Ser Glu Gly Glu Glu Ser 
1               5                   10                  15      


Thr Val Arg Phe Ala Arg Lys Gly Ala Leu Arg Gln Lys Asn Val His 
            20                  25                  30          


Glu Val Lys Asn His Lys Phe Thr Ala Arg Phe Phe Lys Gln Pro Thr 
        35                  40                  45              


Phe Cys Ser His Cys Thr Asp Phe Ile Trp Gly Phe Gly Lys Gln Gly 
    50                  55                  60                  


Phe Gln Cys Gln Val Cys Cys Phe Val Val His Lys Arg Cys His Glu 
65                  70                  75                  80  


Phe Val Thr Phe Ser Cys Pro Gly Ala Asp Lys Gly Pro Ala Ser Asp 
                85                  90                  95      


Asp Pro Arg Ser Lys His Lys Phe Lys Ile His Thr Tyr Ser Ser Pro 
            100                 105                 110         


Thr Phe Cys Asp His Cys Gly Ser Leu Leu Tyr Gly Leu Ile His Gln 
        115                 120                 125             


Gly Met Lys Cys Asp Thr Cys Met Met Asn Val His Lys Arg Cys Val 
    130                 135                 140                 


Met Asn Val Pro Ser Leu Cys Gly Thr Asp His Thr Glu Arg Arg Gly 
145                 150                 155                 160 


Arg Ile Tyr Ile Gln Ala His Ile Asp Arg Asp Val Leu Ile Val Leu 
                165                 170                 175     


Val Arg Asp Ala Lys Asn Leu Val Pro Met Asp Pro Asn Gly Leu Ser 
            180                 185                 190         


Asp Pro Tyr Val Lys Leu Lys Leu Ile Pro Asp Pro Lys Ser Glu Ser 
        195                 200                 205             


Lys Gln Lys Thr Lys Thr Ile Lys Cys Ser Leu Asn Pro Glu Trp Asn 
    210                 215                 220                 


Glu Thr Phe Arg Phe Gln Leu Lys Glu Ser Asp Lys Asp Arg Arg Leu 
225                 230                 235                 240 


Ser Val Glu Ile Trp Asp Trp Asp Leu Thr Ser Arg Asn Asp Phe Met 
                245                 250                 255     


Gly Ser Leu Ser Phe Gly Ile Ser Glu Leu Gln Lys Ala Ser Val Asp 
            260                 265                 270         


Gly Trp Phe Lys Leu Leu Ser Gln Glu Glu Gly Glu Tyr Phe Asn Val 
        275                 280                 285             


Pro Val Pro Pro Glu Gly Ser Glu Ala Asn Glu Glu Leu Arg Gln Lys 
    290                 295                 300                 


Phe Glu Arg Ala Lys Ile Ser Gln Gly Thr Lys Val Pro Glu Glu Lys 
305                 310                 315                 320 


Thr Thr Asn Thr Val Ser Lys Phe Asp Asn Asn Gly Asn Arg Asp Arg 
                325                 330                 335     


Met Lys Leu Thr Asp Phe Asn Phe Leu Met Val Leu Gly Lys Gly Ser 
            340                 345                 350         


Phe Gly Lys Val Met Leu Ser Glu Arg Lys Gly Thr Asp Glu Leu Tyr 
        355                 360                 365             


Ala Val Lys Ile Leu Lys Lys Asp Val Val Ile Gln Asp Asp Asp Val 
    370                 375                 380                 


Glu Cys Thr Met Val Glu Lys Arg Val Leu Ala Leu Pro Gly Lys Pro 
385                 390                 395                 400 


Pro Phe Leu Thr Gln Leu His Ser Cys Phe Gln Thr Met Asp Arg Leu 
                405                 410                 415     


Tyr Phe Val Ile Glu Tyr Val Asn Gly Gly Asp Leu Met Tyr His Ile 
            420                 425                 430         


Gln Gln Val Gly Arg Phe Lys Glu Pro His Ala Val Phe Tyr Ala Ala 
        435                 440                 445             


Glu Ile Ala Ile Gly Leu Phe Phe Leu Gln Ser Lys Gly Ile Ile Tyr 
    450                 455                 460                 


Arg Asp Leu Lys Leu Asp Asn Val Met Leu Asp Ser Glu Gly His Ile 
465                 470                 475                 480 


Lys Ile Ala Asp Phe Gly Met Cys Lys Glu Asn Ile Trp Asp Gly Val 
                485                 490                 495     


Thr Thr Lys Thr Phe Cys Gly Thr Pro Asp Tyr Ile Ala Pro Glu Ile 
            500                 505                 510         


Ile Ala Tyr Gln Pro Tyr Gly Lys Ser Val Asp Trp Trp Ala Phe Gly 
        515                 520                 525             


Val Leu Leu Tyr Glu Met Leu Ala Gly Gln Ala Pro Phe Glu Gly Glu 
    530                 535                 540                 


Asp Glu Asp Glu Leu Phe Gln Ser Ile Met Glu His Asn Val Ala Tyr 
545                 550                 555                 560 


Pro Lys Ser Met Ser Lys Glu Ala Val Ala Ile Cys Lys Gly Leu Met 
                565                 570                 575     


Thr Lys His Pro Gly Lys Arg Leu Gly Cys Gly Pro Glu Gly Glu Arg 
            580                 585                 590         


Asp Ile Lys Glu His Ala Phe Phe Arg Tyr Ile Asp Trp Glu Lys Leu 
        595                 600                 605             


Glu Arg Lys Glu Ile Gln Pro Pro Tyr Lys Pro Lys Ala Arg Asp Lys 
    610                 615                 620                 


Arg Asp Thr Ser Asn Phe Asp Lys Glu Phe Thr Arg Gln Pro Val Glu 
625                 630                 635                 640 


Leu Thr Pro Thr Asp Lys Leu Phe Ile Met Asn Leu Asp Gln Asn Glu 
                645                 650                 655     


Phe Ala Gly Phe Ser Tyr Thr Asn Pro Glu Phe Val Ile Asn Val 
            660                 665                 670     


<210>  853
<211>  8014
<212>  DNA
<213>  Homo sapiens

<400>  853
agctggacga gcggcagcag ctgggcgagt gacagccccg gctccgcgcg ccgcggccgc       60

cagagccggc gcaggggaag cgcccgcggc cccgggtgca gcagcggccg ccgcctcccg      120

cgcctccccg gcccgcagcc cgcggtcccg cggccccggg gccggcacct ctcgggctcc      180

ggctccccgc gcgcaagatg gctgacccgg ctgcggggcc gccgccgagc gagggcgagg      240

agagcaccgt gcgcttcgcc cgcaaaggcg ccctccggca gaagaacgtg catgaggtca      300

agaaccacaa attcaccgcc cgcttcttca agcagcccac cttctgcagc cactgcaccg      360

acttcatctg gggcttcggg aagcagggat tccagtgcca agtttgctgc tttgtggtgc      420

acaagcggtg ccatgaattt gtcacattct cctgccctgg cgctgacaag ggtccagcct      480

ccgatgaccc ccgcagcaaa cacaagttta agatccacac gtactccagc cccacgtttt      540

gtgaccactg tgggtcactg ctgtatggac tcatccacca ggggatgaaa tgtgacacct      600

gcatgatgaa tgtgcacaag cgctgcgtga tgaatgttcc cagcctgtgt ggcacggacc      660

acacggagcg ccgcggccgc atctacatcc aggcccacat cgacagggac gtcctcattg      720

tcctcgtaag agatgctaaa aaccttgtac ctatggaccc caatggcctg tcagatccct      780

acgtaaaact gaaactgatt cccgatccca aaagtgagag caaacagaag accaaaacca      840

tcaaatgctc cctcaaccct gagtggaatg agacatttag atttcagctg aaagaatcgg      900

acaaagacag aagactgtca gtagagattt gggattggga tttgaccagc aggaatgact      960

tcatgggatc tttgtccttt gggatttctg aacttcagaa agccagtgtt gatggctggt     1020

ttaagttact gagccaggag gaaggcgagt acttcaatgt gcctgtgcca ccagaaggaa     1080

gtgaggccaa tgaagaactg cggcagaaat ttgagagggc caagatcagt cagggaacca     1140

aggtcccgga agaaaagacg accaacactg tctccaaatt tgacaacaat ggcaacagag     1200

accggatgaa actgaccgat tttaacttcc taatggtgct ggggaaaggc agctttggca     1260

aggtcatgct ttcagaacga aaaggcacag atgagctcta tgctgtgaag atcctgaaga     1320

aggacgttgt gatccaagat gatgacgtgg agtgcactat ggtggagaag cgggtgttgg     1380

ccctgcctgg gaagccgccc ttcctgaccc agctccactc ctgcttccag accatggacc     1440

gcctgtactt tgtgatggag tacgtgaatg ggggcgacct catgtatcac atccagcaag     1500

tcggccggtt caaggagccc catgctgtat tttacgctgc agaaattgcc atcggtctgt     1560

tcttcttaca gagtaagggc atcatttacc gtgacctaaa acttgacaac gtgatgctcg     1620

attctgaggg acacatcaag attgccgatt ttggcatgtg taaggaaaac atctgggatg     1680

gggtgacaac caagacattc tgtggcactc cagactacat cgcccccgag ataattgctt     1740

atcagcccta tgggaagtcc gtggattggt gggcatttgg agtcctgctg tatgaaatgt     1800

tggctgggca ggcacccttt gaaggggagg atgaagatga actcttccaa tccatcatgg     1860

aacacaacgt agcctatccc aagtctatgt ccaaggaagc tgtggccatc tgcaaagggc     1920

tgatgaccaa acacccaggc aaacgtctgg gttgtggacc tgaaggcgaa cgtgatatca     1980

aagagcatgc atttttccgg tatattgatt gggagaaact tgaacgcaaa gagatccagc     2040

ccccttataa gccaaaagct tgtgggcgaa atgctgaaaa cttcgaccga tttttcaccc     2100

gccatccacc agtcctaaca cctcccgacc aggaagtcat caggaatatt gaccaatcag     2160

aattcgaagg attttccttt gttaactctg aatttttaaa acccgaagtc aagagctaag     2220

tagatgtgta gatctccgtc cttcatttct gtcattcaag ctcaacggct attgtggtga     2280

catttttatg tttttcattg ccaagttgca tccatgtttg attttctgat gagactagag     2340

tgacagtgtt tcagaaccca aatgtcctca ggtagtttgg agcatctcta tgagatggga     2400

ttatgcagat ggcctatgga aaatgcagct gcataattaa cacattatca aagtcctctt     2460

acaatttatt ttccgcagca tgtcagctaa gtagacccaa tggggagaga aaatgcctgc     2520

tttctttccc tctttttctg cactgccata ttcaccccca accatccaat ctgtggataa     2580

ttggatgtta gcggtactct tccacttccg ggcctggagc ttggcttgta tccaagtgta     2640

tggttgcttt gcctaagagg aatccctcta tttcacctgt tctggaggca ccagaccttg     2700

aaaagaacat gctcaaaata aaatgttatc tgttattttt gtaaactcaa agttaagatg     2760

atcaaagttc taaaattcca agaatgtgct tttagacggt ctcaatctaa aagcacttca     2820

aggggtcaaa gggcaaccag cttgggtgct acctcagtgt tgtagtttct gatactttat     2880

gtctttgctc accctcatcc ccaaactact tgaaaagggc atttggcacc actctctgaa     2940

acaacacagt cactctagca aggcccccaa agggccctgg ttttacatta catttcaaac     3000

tttatttgct ttggggtttt gtttctgttg ttgttcaaat gcaaaaaaaa gaaaaaaaaa     3060

gaaaaaaaaa ggtgactcac attgttacac atgctttaaa atatgtattc aaatgttatt     3120

aaccacaatg acgacctgct ttgatttaac caagaagacg gctgcggagc ctagcagact     3180

caggcctgtg ggaatgggat ttgttacaaa tctaggtttg ttactggctt cagaaagcta     3240

attaagtgct ctgaaaaaga caccgtttct tgaaacaaag atggttgtat tcctcacttt     3300

gatgttgttt tgcaagatgt ttgtggaaat gttcatttgt atctggatct ctgttatgtg     3360

ccatttttct tctagcatcg agatacaata aaaaaaaaaa aaaagaaaag aagaagaaat     3420

actatttcaa ggaaaactgc tctttttgag aaacgtggac ctaaactaca aagtgggaac     3480

tgaggaggga actcaggaga aaggaactaa ctgcggagct ttaatcttgg ccccagtgtt     3540

cagccactcg gaggggcggg ggctgtggcc cattcagggg ctgctggtgg gctgtagtgg     3600

ggtgggatga cctggccaga gccaacgagg atactggagc ccaaagtcaa gtttagagac     3660

cagctgggaa cgtgaatggg gctcttgatt ttcttatcaa aatcaccact cctcccagct     3720

tggactaaat attctttcta gcaagcagct ttgtgagctc cctgaagccc aaggaaaccc     3780

ttcggtggga gaaatttcat ttctgtctga gaggattaag gcagcaggtg actccccctc     3840

ctcgcctgcc gtgtcctgct attctcaggc agctctaagg agaattctta tcacagttca     3900

agtgatttcc agaagttcca gggcttctga gagaccatca agggaacttt aacaacttga     3960

caaatgtcct tgaagtaaga tgcctcatct ttagggaaaa atggggtttg gatttctgct     4020

taggcaaagt ctcctgcagt tcatccttct ctgtcctctt cttgcttcag gcttggggac     4080

cgtccctgct gtccccactg tggtggcaat caggacctaa ggtgaagcaa acttgaagtt     4140

ctatctgaca agtttaggca gtaagagaag gagggaaatc ggagcaaagc tccctcactt     4200

tattgttgag aaactggcat ctggaaagag gaaggaattt gcccaaagtc agtcagctgg     4260

gataaaaacc tgggtgtcct gtccagaaag tgcagggtgc tttctgctct gtagcaaggc     4320

agcagacatc tctgagccag gcccaccaac aggcccttat ctggtggttg gatcatgatc     4380

ccattttgct tggacatgct ctcaggaaga taaaaaccat ggagaaacac taggccattg     4440

acaaatgatc tgagacaact ttagaaaaca atgtaggatg aatggaaaga gaaagaaagg     4500

aaagaaagaa gaaaaagaaa gaaggaaaga aagaaagaga aaggaaggaa ggaaagaagg     4560

aaggaaaaga aggaaggaag gaaggaatat agtgttataa atactgcact caacattttc     4620

caaattcttg ccattatttt tcaaaagttt aatagtttgc agaaatagat actcaagcca     4680

aagtctgttt tagagaaact ttccatggaa agtcagaatt tctaccactt ccttttctat     4740

ccacatttcc agtgcagaag aaactgagaa acagagcttt ttgaagagag gacagggcca     4800

tagcaacaag gaccttcttg ggggattaat gggaggtcag tagaattaat aaccctcctt     4860

ggatgagtgc tactgttttc acatggcttc agatgctatc aacctcaaag aaatgatctc     4920

aacagagaag cttattctct cccaacttct acggtaaaat ccaggagtat tttctctggg     4980

gatctgccca caggacaaag tccataaaag caagtcctgt ctggaccatg tggttatctg     5040

aagcattagc catcaccagc acaacaaacg gggcagggct ttccaaggtg gggctggtca     5100

gaagggaatc tttgataaga ggcccacagg cagggaaagc gaaatagggt tgatgagacc     5160

aggggagacc taaaaaaaag gcagctttgt gtcttctagc tccaaatata cctgcctttt     5220

agctcacaca ctgtcctgga gttctcagac ctttaggggc cctaacacag ttcagttcat     5280

acaggggttc aaaagggaca gtggcccatt tgggagacct ttaggatcaa tgggaatcaa     5340

ttccattgtt ttgcctcaga gtaaagtttc tggctcgggg acaattataa gttgcaaaaa     5400

ggatagaggc atatcccaag tcttccttca ttccacaaat aattacaaac aacctactgt     5460

gtgccaggca ctattcttag cactggaaat acactagtga agaagcagat gaggaccctg     5520

tttattgttt ctctccaaga aattctccaa gaatattgtt tcttggagag aaataataaa     5580

taaacaagac aatttctgaa agcaataagt gcaatcaaga taattaaagg atgctaaagt     5640

gtgacttgtg gggattggga gagagatgca cagacaatat taaagaggag gcattcgagc     5700

tttgttgtga acaccggaag taacatgccg agcgcctggg ggatggaaac tcctatagca     5760

ccccacaggc taacagcaag caggacaaga caaaaagggc aggtgggaca tggtagagat     5820

ggaccctacc caggaaacag ctccatcagc atcttagcct gccccactct agccacacat     5880

acccacgtgt gctcctgagt tcagtgtgcc cacctcactc ccacaccctc acatagactt     5940

ggcaagagta aggagggaac tccatagaga cattttacct atctcagggg agcagccaca     6000

aagaagcaag tcttgtaaaa ggtcttttgc aaaggagagt gaacccagca atgagagatc     6060

cttaacagct agtgcccatt agggggctaa acctaaagcc tgggtggtga tggctcaaac     6120

gctaatgagt cagtgaatcc ttaccgaccc cctggccttt ataatctgag gcaactttgg     6180

ctgcagcccg ggaatgtgca gggcactagg gaatacaagg ccttcttccc tggttgtctt     6240

gtaataaaac agccatgggg ttgtccctcc agtccgagag actgtgatga ggcctacata     6300

gcagcgatgt ggtcaggtaa aaatcaggaa cccactgaaa tcttgggcaa gccaccctgc     6360

ctgcttgtgc ctcggttctc tcatatgtca tatataggag gtgaggactc cagctccacc     6420

tgccccaggt gggtgtggtg atgatgagga aagacaagag gcttgcaagg accctgaaga     6480

ggtcggagca tcatacagat tcctttatta gcccacattc tgatgttccc tggtgagact     6540

tgccccaagc aattgctagt aaatgggggt taatttcttc tccacctccc tactgaacaa     6600

aaaaagaaat gccagactta ctaggagaat cgagttgctt tgagtttctt ttgttttgtt     6660

ttgttttgtt ttgttttaag gctcccctta cacaccctcc tttaagcttt gggttttctc     6720

tcttatagtt tgttgacaca tgctaaaaat gtctttggag agaacttctg cctgataaac     6780

acccaattct agactgtggg tggattttcg agctgacggt ggtcaattcc tttcattaag     6840

cagtgatctg atttctccac atggccattc tgccttcttg ggggcagagt agatgggcag     6900

cagttcacct tttcagagaa agaggtcttc tagccacctg ggctgctact gaatggtttt     6960

ctccaggacg ctctacctaa tgattatttc tataacatta agcatggtaa taagtagctt     7020

ccaattcaat tcatcctaaa gccaaagaaa atacagcaac acacacacac acacacacac     7080

acacacacac acacacacac acacaccact ttatggcaat tcttaactga cattcaatga     7140

cttacttctt ttcttagaaa atttccacca catttctatc cccaagccaa catacaatgt     7200

gaaatgaaag ccagtgcgtg gagtgcagct gctaaaaatt ttcagcacag ggctctttct     7260

gactctgctc atgagatggt atcagccacc caatgactgg cgtatcttgg tcctgtgtct     7320

ttcttcttac gctgtgttaa tgtgtttact ttccatttgg cagagagaca agagagacac     7380

ctccaacttc gacaaagagt tcaccagaca gcctgtggaa ctgaccccca ctgataaact     7440

cttcatcatg aacttggacc aaaatgaatt tgctggcttc tcttatacta acccagagtt     7500

tgtcattaat gtgtaggtga atgcaaactc catcgttgag cctggggtgt aagacttcaa     7560

gccaagcgta tgtatcaatt ctagtcttcc aggattcacg gtgcacatgc tggcattcaa     7620

catgtggaaa gcttgtctta gagggctttt ctttgtatgt gtagcttgct agtttgtttt     7680

ctacatttga aaatgtttag tttagaataa gcgcattatc caattataga ggtacaattt     7740

tccaaacttc cagaaactca tcaaatgaac agacaatgtc aaaactactg tgtctgatac     7800

caaaatgctt cagtatttgt aatttttcaa gtcagaagct gatgttcctg gtaaaagttt     7860

ttacagttat tctataatat cttctttgaa tgctaagcat gagcgatatt tttaaaaatt     7920

gtgagtaagc tttgcagtta ctgtgaacta ttgtctcttg gaggaagttt tttgtttaag     7980

aattgatatg attaaactga attaatatat gcaa                                 8014


<210>  854
<211>  671
<212>  PRT
<213>  Homo sapiens

<400>  854

Met Ala Asp Pro Ala Ala Gly Pro Pro Pro Ser Glu Gly Glu Glu Ser 
1               5                   10                  15      


Thr Val Arg Phe Ala Arg Lys Gly Ala Leu Arg Gln Lys Asn Val His 
            20                  25                  30          


Glu Val Lys Asn His Lys Phe Thr Ala Arg Phe Phe Lys Gln Pro Thr 
        35                  40                  45              


Phe Cys Ser His Cys Thr Asp Phe Ile Trp Gly Phe Gly Lys Gln Gly 
    50                  55                  60                  


Phe Gln Cys Gln Val Cys Cys Phe Val Val His Lys Arg Cys His Glu 
65                  70                  75                  80  


Phe Val Thr Phe Ser Cys Pro Gly Ala Asp Lys Gly Pro Ala Ser Asp 
                85                  90                  95      


Asp Pro Arg Ser Lys His Lys Phe Lys Ile His Thr Tyr Ser Ser Pro 
            100                 105                 110         


Thr Phe Cys Asp His Cys Gly Ser Leu Leu Tyr Gly Leu Ile His Gln 
        115                 120                 125             


Gly Met Lys Cys Asp Thr Cys Met Met Asn Val His Lys Arg Cys Val 
    130                 135                 140                 


Met Asn Val Pro Ser Leu Cys Gly Thr Asp His Thr Glu Arg Arg Gly 
145                 150                 155                 160 


Arg Ile Tyr Ile Gln Ala His Ile Asp Arg Asp Val Leu Ile Val Leu 
                165                 170                 175     


Val Arg Asp Ala Lys Asn Leu Val Pro Met Asp Pro Asn Gly Leu Ser 
            180                 185                 190         


Asp Pro Tyr Val Lys Leu Lys Leu Ile Pro Asp Pro Lys Ser Glu Ser 
        195                 200                 205             


Lys Gln Lys Thr Lys Thr Ile Lys Cys Ser Leu Asn Pro Glu Trp Asn 
    210                 215                 220                 


Glu Thr Phe Arg Phe Gln Leu Lys Glu Ser Asp Lys Asp Arg Arg Leu 
225                 230                 235                 240 


Ser Val Glu Ile Trp Asp Trp Asp Leu Thr Ser Arg Asn Asp Phe Met 
                245                 250                 255     


Gly Ser Leu Ser Phe Gly Ile Ser Glu Leu Gln Lys Ala Ser Val Asp 
            260                 265                 270         


Gly Trp Phe Lys Leu Leu Ser Gln Glu Glu Gly Glu Tyr Phe Asn Val 
        275                 280                 285             


Pro Val Pro Pro Glu Gly Ser Glu Ala Asn Glu Glu Leu Arg Gln Lys 
    290                 295                 300                 


Phe Glu Arg Ala Lys Ile Ser Gln Gly Thr Lys Val Pro Glu Glu Lys 
305                 310                 315                 320 


Thr Thr Asn Thr Val Ser Lys Phe Asp Asn Asn Gly Asn Arg Asp Arg 
                325                 330                 335     


Met Lys Leu Thr Asp Phe Asn Phe Leu Met Val Leu Gly Lys Gly Ser 
            340                 345                 350         


Phe Gly Lys Val Met Leu Ser Glu Arg Lys Gly Thr Asp Glu Leu Tyr 
        355                 360                 365             


Ala Val Lys Ile Leu Lys Lys Asp Val Val Ile Gln Asp Asp Asp Val 
    370                 375                 380                 


Glu Cys Thr Met Val Glu Lys Arg Val Leu Ala Leu Pro Gly Lys Pro 
385                 390                 395                 400 


Pro Phe Leu Thr Gln Leu His Ser Cys Phe Gln Thr Met Asp Arg Leu 
                405                 410                 415     


Tyr Phe Val Met Glu Tyr Val Asn Gly Gly Asp Leu Met Tyr His Ile 
            420                 425                 430         


Gln Gln Val Gly Arg Phe Lys Glu Pro His Ala Val Phe Tyr Ala Ala 
        435                 440                 445             


Glu Ile Ala Ile Gly Leu Phe Phe Leu Gln Ser Lys Gly Ile Ile Tyr 
    450                 455                 460                 


Arg Asp Leu Lys Leu Asp Asn Val Met Leu Asp Ser Glu Gly His Ile 
465                 470                 475                 480 


Lys Ile Ala Asp Phe Gly Met Cys Lys Glu Asn Ile Trp Asp Gly Val 
                485                 490                 495     


Thr Thr Lys Thr Phe Cys Gly Thr Pro Asp Tyr Ile Ala Pro Glu Ile 
            500                 505                 510         


Ile Ala Tyr Gln Pro Tyr Gly Lys Ser Val Asp Trp Trp Ala Phe Gly 
        515                 520                 525             


Val Leu Leu Tyr Glu Met Leu Ala Gly Gln Ala Pro Phe Glu Gly Glu 
    530                 535                 540                 


Asp Glu Asp Glu Leu Phe Gln Ser Ile Met Glu His Asn Val Ala Tyr 
545                 550                 555                 560 


Pro Lys Ser Met Ser Lys Glu Ala Val Ala Ile Cys Lys Gly Leu Met 
                565                 570                 575     


Thr Lys His Pro Gly Lys Arg Leu Gly Cys Gly Pro Glu Gly Glu Arg 
            580                 585                 590         


Asp Ile Lys Glu His Ala Phe Phe Arg Tyr Ile Asp Trp Glu Lys Leu 
        595                 600                 605             


Glu Arg Lys Glu Ile Gln Pro Pro Tyr Lys Pro Lys Ala Arg Asp Lys 
    610                 615                 620                 


Arg Asp Thr Ser Asn Phe Asp Lys Glu Phe Thr Arg Gln Pro Val Glu 
625                 630                 635                 640 


Leu Thr Pro Thr Asp Lys Leu Phe Ile Met Asn Leu Asp Gln Asn Glu 
                645                 650                 655     


Phe Ala Gly Phe Ser Tyr Thr Asn Pro Glu Phe Val Ile Asn Val 
            660                 665                 670     


<210>  855
<211>  673
<212>  PRT
<213>  Homo sapiens

<400>  855

Met Ala Asp Pro Ala Ala Gly Pro Pro Pro Ser Glu Gly Glu Glu Ser 
1               5                   10                  15      


Thr Val Arg Phe Ala Arg Lys Gly Ala Leu Arg Gln Lys Asn Val His 
            20                  25                  30          


Glu Val Lys Asn His Lys Phe Thr Ala Arg Phe Phe Lys Gln Pro Thr 
        35                  40                  45              


Phe Cys Ser His Cys Thr Asp Phe Ile Trp Gly Phe Gly Lys Gln Gly 
    50                  55                  60                  


Phe Gln Cys Gln Val Cys Cys Phe Val Val His Lys Arg Cys His Glu 
65                  70                  75                  80  


Phe Val Thr Phe Ser Cys Pro Gly Ala Asp Lys Gly Pro Ala Ser Asp 
                85                  90                  95      


Asp Pro Arg Ser Lys His Lys Phe Lys Ile His Thr Tyr Ser Ser Pro 
            100                 105                 110         


Thr Phe Cys Asp His Cys Gly Ser Leu Leu Tyr Gly Leu Ile His Gln 
        115                 120                 125             


Gly Met Lys Cys Asp Thr Cys Met Met Asn Val His Lys Arg Cys Val 
    130                 135                 140                 


Met Asn Val Pro Ser Leu Cys Gly Thr Asp His Thr Glu Arg Arg Gly 
145                 150                 155                 160 


Arg Ile Tyr Ile Gln Ala His Ile Asp Arg Asp Val Leu Ile Val Leu 
                165                 170                 175     


Val Arg Asp Ala Lys Asn Leu Val Pro Met Asp Pro Asn Gly Leu Ser 
            180                 185                 190         


Asp Pro Tyr Val Lys Leu Lys Leu Ile Pro Asp Pro Lys Ser Glu Ser 
        195                 200                 205             


Lys Gln Lys Thr Lys Thr Ile Lys Cys Ser Leu Asn Pro Glu Trp Asn 
    210                 215                 220                 


Glu Thr Phe Arg Phe Gln Leu Lys Glu Ser Asp Lys Asp Arg Arg Leu 
225                 230                 235                 240 


Ser Val Glu Ile Trp Asp Trp Asp Leu Thr Ser Arg Asn Asp Phe Met 
                245                 250                 255     


Gly Ser Leu Ser Phe Gly Ile Ser Glu Leu Gln Lys Ala Ser Val Asp 
            260                 265                 270         


Gly Trp Phe Lys Leu Leu Ser Gln Glu Glu Gly Glu Tyr Phe Asn Val 
        275                 280                 285             


Pro Val Pro Pro Glu Gly Ser Glu Ala Asn Glu Glu Leu Arg Gln Lys 
    290                 295                 300                 


Phe Glu Arg Ala Lys Ile Ser Gln Gly Thr Lys Val Pro Glu Glu Lys 
305                 310                 315                 320 


Thr Thr Asn Thr Val Ser Lys Phe Asp Asn Asn Gly Asn Arg Asp Arg 
                325                 330                 335     


Met Lys Leu Thr Asp Phe Asn Phe Leu Met Val Leu Gly Lys Gly Ser 
            340                 345                 350         


Phe Gly Lys Val Met Leu Ser Glu Arg Lys Gly Thr Asp Glu Leu Tyr 
        355                 360                 365             


Ala Val Lys Ile Leu Lys Lys Asp Val Val Ile Gln Asp Asp Asp Val 
    370                 375                 380                 


Glu Cys Thr Met Val Glu Lys Arg Val Leu Ala Leu Pro Gly Lys Pro 
385                 390                 395                 400 


Pro Phe Leu Thr Gln Leu His Ser Cys Phe Gln Thr Met Asp Arg Leu 
                405                 410                 415     


Tyr Phe Val Ile Glu Tyr Val Asn Gly Gly Asp Leu Met Tyr His Ile 
            420                 425                 430         


Gln Gln Val Gly Arg Phe Lys Glu Pro His Ala Val Phe Tyr Ala Ala 
        435                 440                 445             


Glu Ile Ala Ile Gly Leu Phe Phe Leu Gln Ser Lys Gly Ile Ile Tyr 
    450                 455                 460                 


Arg Asp Leu Lys Leu Asp Asn Val Met Leu Asp Ser Glu Gly His Ile 
465                 470                 475                 480 


Lys Ile Ala Asp Phe Gly Met Cys Lys Glu Asn Ile Trp Asp Gly Val 
                485                 490                 495     


Thr Thr Lys Thr Phe Cys Gly Thr Pro Asp Tyr Ile Ala Pro Glu Ile 
            500                 505                 510         


Ile Ala Tyr Gln Pro Tyr Gly Lys Ser Val Asp Trp Trp Ala Phe Gly 
        515                 520                 525             


Val Leu Leu Tyr Glu Met Leu Ala Gly Gln Ala Pro Phe Glu Gly Glu 
    530                 535                 540                 


Asp Glu Asp Glu Leu Phe Gln Ser Ile Met Glu His Asn Val Ala Tyr 
545                 550                 555                 560 


Pro Lys Ser Met Ser Lys Glu Ala Val Ala Ile Cys Lys Gly Leu Met 
                565                 570                 575     


Thr Lys His Pro Gly Lys Arg Leu Gly Cys Gly Pro Glu Gly Glu Arg 
            580                 585                 590         


Asp Ile Lys Glu His Ala Phe Phe Arg Tyr Ile Asp Trp Glu Lys Leu 
        595                 600                 605             


Glu Arg Lys Glu Ile Gln Pro Pro Tyr Lys Pro Lys Ala Cys Gly Arg 
    610                 615                 620                 


Asn Ala Glu Asn Phe Asp Arg Phe Phe Thr Arg His Pro Pro Val Leu 
625                 630                 635                 640 


Thr Pro Pro Asp Gln Glu Val Ile Arg Asn Ile Asp Gln Ser Glu Phe 
                645                 650                 655     


Glu Gly Phe Ser Phe Val Asn Ser Glu Phe Leu Lys Pro Glu Val Lys 
            660                 665                 670         


Ser 
    


<210>  856
<211>  5537
<212>  DNA
<213>  Homo sapiens

<400>  856
gaacccggcg aggaaataca tgcactggct gagaatcgcc cgcgccaggg cgcaacgcca       60

caaggtgtag ggagtgtgcg gggtggggcg aaaggggacc caagagtccc tgtggctcgg      120

agtgccgggc cgtcggttct tcattcctgc cctcggggca gacggagtga ccccggcccc      180

cactccccgc cccgaccatg gtagtgttca atggccttct taagatcaaa atctgcgagg      240

ccgtgagctt gaagcccaca gcctggtcgc tgcgccatgc ggtgggaccc cggccgcaga      300

ctttccttct cgacccctac attgccctca atgtggacga ctcgcgcatc ggccaaacgg      360

ccaccaagca gaagaccaac agcccggcct ggcacgacga gttcgtcacc gatgtgtgca      420

acggacgcaa gatcgagctg gctgtctttc acgatgcccc cataggctac gacgacttcg      480

tggccaactg caccatccag tttgaggagc tgctgcagaa cgggagccgc cacttcgagg      540

actggattga tctggagcca gaaggaagag tgtatgtgat catcgatctc tcagggtcgt      600

cgggtgaagc ccctaaagac aatgaagagc gtgtgttcag ggaacgcatg cggccgagga      660

agcggcaggg ggccgtcagg cgcagggtcc atcaggtcaa cggccacaag ttcatggcca      720

cctatcttcg gcagcccacc tactgctccc attgcagaga cttcatctgg ggtgtcatag      780

gaaagcaggg ataccagtgt caagtctgca cctgcgtggt ccacaagcgg tgccacgagc      840

tcataatcac aaagtgtgct gggttaaaga agcaggagac ccccgaccag gtgggctccc      900

agcggttcag cgtcaacatg ccccacaagt tcggtatcca caactacaag gtccctacct      960

tctgcgatca ctgtgggtcc ctgctctggg gactcttgcg gcagggtttg cagtgtaaag     1020

tctgcaaaat gaatgttcac cgtcgatgtg agaccaacgt ggctcccaac tgtggagtgg     1080

atgccagagg aatcgccaaa gtactggccg acctgggcgt taccccagac aaaatcacca     1140

acagcggcca gagaaggaaa aagctcattg ctggtgccga gtccccgcag cctgcttctg     1200

gaagctcacc atctgaggaa gatcgatcca agtcagcacc cacctcccct tgtgaccagg     1260

aaataaaaga acttgagaac aacattcgga aagccttgtc atttgacaac cgaggagagg     1320

agcaccgggc agcatcgtct cctgatggcc agctgatgag ccccggtgag aatggcgaag     1380

tccggcaagg ccaggccaag cgcctgggcc tggatgagtt caacttcatc aaggtgttgg     1440

gcaaaggcag ctttggcaag gtcatgttgg cagaactcaa gggcaaagat gaagtatatg     1500

ctgtgaaggt cttaaagaag gacgtcatcc ttcaggatga tgacgtggac tgcacaatga     1560

cagagaagag gattttggct ctggcacgga aacacccgta ccttacccaa ctctactgct     1620

gcttccagac caaggaccgc ctctttttcg tcatggaata tgtaaatggt ggagacctca     1680

tgtttcagat tcagcgctcc cgaaaattcg acgagcctcg ttcacggttc tatgctgcag     1740

aggtcacatc ggccctcatg ttcctccacc agcatggagt catctacagg gatttgaaac     1800

tggacaacat ccttctggat gcagaaggtc actgcaagct ggctgacttc gggatgtgca     1860

aggaagggat tctgaatggt gtgacgacca ccacgttctg tgggactcct gactacatag     1920

ctcctgagat cctgcaggag ttggagtatg gcccctccgt ggactggtgg gccctggggg     1980

tgctgatgta cgagatgatg gctggacagc ctccctttga ggccgacaat gaggacgacc     2040

tatttgagtc catcctccat gacgacgtgc tgtacccagt ctggctcagc aaggaggctg     2100

tcagcatctt gaaagctttc atgacgaaga atccccacaa gcgcctgggc tgtgtggcat     2160

cgcagaatgg cgaggacgcc atcaagcagc acccattctt caaagagatt gactgggtgc     2220

tcctggagca gaagaagatc aagccaccct tcaaaccacg cattaaaacc aaaagagacg     2280

tcaataattt tgaccaagac tttacccggg aagagccggt actcaccctt gtggacgaag     2340

caattgtaaa gcagatcaac caggaggaat tcaaaggttt ctcctacttt ggtgaagacc     2400

tgatgccctg agagcccact gcagttggac tttgccgatg ctgcaagaag gggtgcagag     2460

aagactcctg tgttggagac actcagcagg tcttgaacta cttctcctcc tcggagcccc     2520

agtcccatgt ccactgtcta tttattgcat tcccttgccc caggccacct cctccccctc     2580

ccacctggtg accagaaggc gctctcggtt cttgtctcac cagtaatgca gactcattgg     2640

gtcagcaatt agctgtatac actgccgtgt ttggaccatt ggcaagcctg gttccactcc     2700

tcaggggctc ctggcagtga agcaacttca gttcttttac tgcaaagaac agaaaaaaga     2760

aagaaagcaa acaagaagac tccggctctg ctatcggaca cagatcctga tccctcttgc     2820

ttcttttccc tcctgcaccg cagcttgcca tccctgccct tctgtcctgg agaagagact     2880

ggtgcttctc cgcacacacg agggagggcg cccttgaggc atgccctctg agggagggag     2940

accagagatg cagggattgg ccagctgggt tggtttgctc tggaatggct aactcttgcc     3000

tgctttggtt ttagcttttc agcatgccaa agtcatgtaa gtttgtgtct tgtggaagaa     3060

atcctctttg tggaaaaaga aacagggttt tgaactctgt taacatttga aaaatatatt     3120

ttcaaattca ctttctaatt ggccaaaaga gatgagttcc agtctgaata caggtagata     3180

ttaaagggct aataaaaaat gagaaaccgg tcgtccaagg tggatgctgt caatgcccga     3240

gtgacacatg agagctgtat gaattgagag aaaaggcaac aagtagcatt cttcatcatt     3300

caagttctac ctggacacaa aggcgaggac cctggggttc caacaaagct cagctcccag     3360

attctctttc cagtttcatc ctaagttcct agcataaaca ctatttattt tctgcagcag     3420

tgtgttattt ttgcgcactt atacaaaatg gtagtactac tgtgttgtgg tttttaaaca     3480

ttaaacatgt aaagttatat acgaaatatc tgcttttgga ataagcagaa tgaggctaaa     3540

catgggttat acaaagggta tctggaaact gaagagcaac ttgttagaaa actgacaatg     3600

tcgcaagatg tactcagttt tgtttctgtg tgacatgcaa tggcaactca tgtggacact     3660

attgaaggga tgtgacatta cctcctgtag atatgctaac agtgttattc tttcatttcc     3720

aagggttctc tgtggctttg tgtatatgtt tcccagaggt catttgatta cctaatttac     3780

tgaactgatt tagcagggaa tggaatccat tccaactatt gcacgtggat ttcccagctg     3840

cccctaaata tatatacttg tgagtggcaa agtggcacta atgaagcttt tgccttttgt     3900

acatttgaga tttttgtata tagtgtttgc tgcaaggcct gtggaattaa ttcgttgcat     3960

atagaggtat caactgctgc atgttcaggc atattataaa actttagtct atgaaagaat     4020

aattataata atgtccaggt gcaatactct gtaagtctat tggttcaagt taccgagaga     4080

taggtgtgtt cctttatggg ggatgggggg gtgtgttggg gattctttgt attgtttatt     4140

tcattttggt ttattttaaa agatgtaaac atatattaag ctatattaaa tctcacatac     4200

agttcttctg tgctctatta taccctgata gagatggggg agagaaagga atgtttttga     4260

tggtggtttc aaagctcgga cagtaactat cttgagccca ttagagagtc tgtgtccata     4320

tttgcatctg gctggtcata gcctttgtta ctaatgatga cattcagttc tcttttgttt     4380

ttatttttta aaaactcagg tgtaattatt atctgttctt aagataattg caaatattaa     4440

atattatgat atatcaattc atgtgtttgg cataccagtg aatgatgaag aacatgagat     4500

taatttaatt tatcttcggt aacttgacat tctggagaga gactatcttc tggagttgag     4560

tacaagcaca gaaacatctt tacggtggca tcatctcatt ttttaggaag acatgataat     4620

actgcccatc atattcatgt gtaactactg ttctttcttc tgctttcttc accataataa     4680

actttggaca accaagcaag ctctaaccgc aatgccagat ggccttgtcc gagggcctag     4740

tgtttgcacg gcagtgggaa ctgggccttt cctacaggac aactggcaag tttgctggga     4800

agtcaaataa tacattccac ctggcagctg aaggcagcca gtcagtctgt cccagaaagg     4860

gcccttttca gcacccaaag ctgggctggc tgggatgcct ctggctggtg aagttctcac     4920

ataggctgat ttaaatccag caaaggtcta tagaaaaagg cttgcgtgtt cgttgagtaa     4980

tcattgtttc attttcattt ttacgagagt ttgaaaatag acacactgtt aacacttctg     5040

ccagtttttt ctgatctttc cagccccacc ccctttctct ttctctctct ctctcaaaga     5100

aaaaaaaaat gggagtgcaa aaaaaacaaa gccaaaaaat atatgaagga tagctgttct     5160

tctgtgttct ctcattatgg actttgtgaa gtagaaacat aatttttttt cctccaaagg     5220

tgaaaaaaca atgcattctt gctttaaaaa aaaaaaagaa ggctaaaaaa ttacctcttt     5280

ttaaattatg tgcaaaataa ttctggctaa ctgtaaaatg tattcaattt taggattttt     5340

tttttttgta ttgtgatgct ttatttgtac atttttttcc tttctggatg taattttaat     5400

ctcttgccat tcattagtgt tatttcattg taaacgttat tgtgccaaat gtactgtatt     5460

caaaaggatg tgaatgtgta ttgtttcaga acctaataaa tacaatgacg ttaagtctta     5520

aaaaaaaaaa aaaaaaa                                                    5537


<210>  857
<211>  737
<212>  PRT
<213>  Homo sapiens

<400>  857

Met Val Val Phe Asn Gly Leu Leu Lys Ile Lys Ile Cys Glu Ala Val 
1               5                   10                  15      


Ser Leu Lys Pro Thr Ala Trp Ser Leu Arg His Ala Val Gly Pro Arg 
            20                  25                  30          


Pro Gln Thr Phe Leu Leu Asp Pro Tyr Ile Ala Leu Asn Val Asp Asp 
        35                  40                  45              


Ser Arg Ile Gly Gln Thr Ala Thr Lys Gln Lys Thr Asn Ser Pro Ala 
    50                  55                  60                  


Trp His Asp Glu Phe Val Thr Asp Val Cys Asn Gly Arg Lys Ile Glu 
65                  70                  75                  80  


Leu Ala Val Phe His Asp Ala Pro Ile Gly Tyr Asp Asp Phe Val Ala 
                85                  90                  95      


Asn Cys Thr Ile Gln Phe Glu Glu Leu Leu Gln Asn Gly Ser Arg His 
            100                 105                 110         


Phe Glu Asp Trp Ile Asp Leu Glu Pro Glu Gly Arg Val Tyr Val Ile 
        115                 120                 125             


Ile Asp Leu Ser Gly Ser Ser Gly Glu Ala Pro Lys Asp Asn Glu Glu 
    130                 135                 140                 


Arg Val Phe Arg Glu Arg Met Arg Pro Arg Lys Arg Gln Gly Ala Val 
145                 150                 155                 160 


Arg Arg Arg Val His Gln Val Asn Gly His Lys Phe Met Ala Thr Tyr 
                165                 170                 175     


Leu Arg Gln Pro Thr Tyr Cys Ser His Cys Arg Asp Phe Ile Trp Gly 
            180                 185                 190         


Val Ile Gly Lys Gln Gly Tyr Gln Cys Gln Val Cys Thr Cys Val Val 
        195                 200                 205             


His Lys Arg Cys His Glu Leu Ile Ile Thr Lys Cys Ala Gly Leu Lys 
    210                 215                 220                 


Lys Gln Glu Thr Pro Asp Gln Val Gly Ser Gln Arg Phe Ser Val Asn 
225                 230                 235                 240 


Met Pro His Lys Phe Gly Ile His Asn Tyr Lys Val Pro Thr Phe Cys 
                245                 250                 255     


Asp His Cys Gly Ser Leu Leu Trp Gly Leu Leu Arg Gln Gly Leu Gln 
            260                 265                 270         


Cys Lys Val Cys Lys Met Asn Val His Arg Arg Cys Glu Thr Asn Val 
        275                 280                 285             


Ala Pro Asn Cys Gly Val Asp Ala Arg Gly Ile Ala Lys Val Leu Ala 
    290                 295                 300                 


Asp Leu Gly Val Thr Pro Asp Lys Ile Thr Asn Ser Gly Gln Arg Arg 
305                 310                 315                 320 


Lys Lys Leu Ile Ala Gly Ala Glu Ser Pro Gln Pro Ala Ser Gly Ser 
                325                 330                 335     


Ser Pro Ser Glu Glu Asp Arg Ser Lys Ser Ala Pro Thr Ser Pro Cys 
            340                 345                 350         


Asp Gln Glu Ile Lys Glu Leu Glu Asn Asn Ile Arg Lys Ala Leu Ser 
        355                 360                 365             


Phe Asp Asn Arg Gly Glu Glu His Arg Ala Ala Ser Ser Pro Asp Gly 
    370                 375                 380                 


Gln Leu Met Ser Pro Gly Glu Asn Gly Glu Val Arg Gln Gly Gln Ala 
385                 390                 395                 400 


Lys Arg Leu Gly Leu Asp Glu Phe Asn Phe Ile Lys Val Leu Gly Lys 
                405                 410                 415     


Gly Ser Phe Gly Lys Val Met Leu Ala Glu Leu Lys Gly Lys Asp Glu 
            420                 425                 430         


Val Tyr Ala Val Lys Val Leu Lys Lys Asp Val Ile Leu Gln Asp Asp 
        435                 440                 445             


Asp Val Asp Cys Thr Met Thr Glu Lys Arg Ile Leu Ala Leu Ala Arg 
    450                 455                 460                 


Lys His Pro Tyr Leu Thr Gln Leu Tyr Cys Cys Phe Gln Thr Lys Asp 
465                 470                 475                 480 


Arg Leu Phe Phe Val Met Glu Tyr Val Asn Gly Gly Asp Leu Met Phe 
                485                 490                 495     


Gln Ile Gln Arg Ser Arg Lys Phe Asp Glu Pro Arg Ser Arg Phe Tyr 
            500                 505                 510         


Ala Ala Glu Val Thr Ser Ala Leu Met Phe Leu His Gln His Gly Val 
        515                 520                 525             


Ile Tyr Arg Asp Leu Lys Leu Asp Asn Ile Leu Leu Asp Ala Glu Gly 
    530                 535                 540                 


His Cys Lys Leu Ala Asp Phe Gly Met Cys Lys Glu Gly Ile Leu Asn 
545                 550                 555                 560 


Gly Val Thr Thr Thr Thr Phe Cys Gly Thr Pro Asp Tyr Ile Ala Pro 
                565                 570                 575     


Glu Ile Leu Gln Glu Leu Glu Tyr Gly Pro Ser Val Asp Trp Trp Ala 
            580                 585                 590         


Leu Gly Val Leu Met Tyr Glu Met Met Ala Gly Gln Pro Pro Phe Glu 
        595                 600                 605             


Ala Asp Asn Glu Asp Asp Leu Phe Glu Ser Ile Leu His Asp Asp Val 
    610                 615                 620                 


Leu Tyr Pro Val Trp Leu Ser Lys Glu Ala Val Ser Ile Leu Lys Ala 
625                 630                 635                 640 


Phe Met Thr Lys Asn Pro His Lys Arg Leu Gly Cys Val Ala Ser Gln 
                645                 650                 655     


Asn Gly Glu Asp Ala Ile Lys Gln His Pro Phe Phe Lys Glu Ile Asp 
            660                 665                 670         


Trp Val Leu Leu Glu Gln Lys Lys Ile Lys Pro Pro Phe Lys Pro Arg 
        675                 680                 685             


Ile Lys Thr Lys Arg Asp Val Asn Asn Phe Asp Gln Asp Phe Thr Arg 
    690                 695                 700                 


Glu Glu Pro Val Leu Thr Leu Val Asp Glu Ala Ile Val Lys Gln Ile 
705                 710                 715                 720 


Asn Gln Glu Glu Phe Lys Gly Phe Ser Tyr Phe Gly Glu Asp Leu Met 
                725                 730                 735     


Pro 
    


<210>  858
<211>  736
<212>  PRT
<213>  Homo sapiens

<400>  858

Met Val Val Phe Asn Gly Leu Leu Lys Ile Lys Ile Cys Glu Ala Val 
1               5                   10                  15      


Ser Leu Lys Pro Thr Ala Trp Ser Leu Arg His Ala Val Gly Pro Arg 
            20                  25                  30          


Pro His Thr Phe Leu Leu Asp Pro Tyr Ile Ala Leu Asn Val Asp Asp 
        35                  40                  45              


Ser Arg Ile Gly Gln Thr Ala Thr Lys Gln Lys Thr Asn Ser Pro Ala 
    50                  55                  60                  


Trp His Asp Glu Phe Val Thr Asp Val Cys Asn Gly Arg Lys Ile Glu 
65                  70                  75                  80  


Leu Ala Val Phe His Asp Ala Pro Ile Gly Tyr Asp Asp Phe Val Ala 
                85                  90                  95      


Asn Cys Thr Ile Gln Phe Glu Glu Leu Leu Gln Asn Gly Ser Arg His 
            100                 105                 110         


Phe Glu Asp Trp Ile Asp Leu Glu Pro Glu Gly Arg Val Tyr Val Ile 
        115                 120                 125             


Ile Asp Leu Ser Gly Ser Ser Gly Glu Ala Pro Lys Asp Asn Glu Glu 
    130                 135                 140                 


Arg Val Phe Arg Glu Arg Met Arg Pro Arg Lys Arg Gln Gly Ala Val 
145                 150                 155                 160 


Arg Arg Arg Val His Gln Val Asn Gly His Lys Phe Met Ala Thr Tyr 
                165                 170                 175     


Leu Arg Gln Pro Thr Tyr Cys Ser His Cys Arg Asp Phe Ile Trp Gly 
            180                 185                 190         


Val Ile Gly Lys Gln Gly Tyr Gln Gln Val Cys Thr Cys Val Val His 
        195                 200                 205             


Lys Arg Cys His Glu Leu Ile Ile Thr Lys Cys Ala Gly Leu Lys Lys 
    210                 215                 220                 


Gln Glu Thr Pro Asp Gln Val Gly Ser Gln Arg Phe Ser Val Asn Met 
225                 230                 235                 240 


Pro His Lys Phe Gly Ile His Asn Tyr Lys Val Pro Thr Phe Cys Asp 
                245                 250                 255     


His Cys Gly Ser Leu Leu Trp Gly Leu Leu Arg Gln Gly Leu Gln Cys 
            260                 265                 270         


Lys Val Cys Lys Met Asn Val His Arg Arg Cys Glu Thr Asn Val Ala 
        275                 280                 285             


Pro Asn Cys Gly Val Asp Ala Arg Gly Ile Ala Lys Val Leu Ala Asp 
    290                 295                 300                 


Leu Gly Val Thr Pro Asp Lys Ile Thr Asn Ser Gly Gln Arg Arg Lys 
305                 310                 315                 320 


Lys Leu Ile Ala Gly Ala Glu Ser Pro Gln Pro Ala Ser Gly Ser Ser 
                325                 330                 335     


Pro Ser Glu Glu Asp Arg Ser Lys Ser Ala Pro Thr Ser Pro Cys Asp 
            340                 345                 350         


Gln Glu Ile Lys Glu Leu Glu Asn Asn Ile Arg Lys Ala Leu Ser Phe 
        355                 360                 365             


Asp Asn Arg Gly Glu Glu His Arg Ala Ala Ser Ser Pro Asp Gly Gln 
    370                 375                 380                 


Leu Met Ser Pro Gly Glu Asn Gly Glu Val Arg Gln Gly Gln Ala Lys 
385                 390                 395                 400 


Arg Leu Gly Leu Asp Glu Phe Asn Phe Ile Lys Val Leu Gly Lys Gly 
                405                 410                 415     


Ser Phe Gly Lys Val Met Leu Ala Glu Leu Lys Gly Lys Asp Glu Val 
            420                 425                 430         


Tyr Ala Val Lys Val Leu Lys Lys Asp Val Ile Leu Gln Asp Asp Asp 
        435                 440                 445             


Val Asp Cys Thr Met Thr Glu Lys Arg Ile Leu Ala Leu Ala Arg Lys 
    450                 455                 460                 


His Pro Tyr Leu Thr Gln Leu Tyr Cys Cys Phe Gln Thr Lys Asp Arg 
465                 470                 475                 480 


Leu Phe Phe Val Met Glu Tyr Val Asn Gly Gly Asp Leu Met Phe Gln 
                485                 490                 495     


Ile Gln Arg Ser Arg Lys Phe Asp Glu Pro Arg Ser Arg Phe Tyr Ala 
            500                 505                 510         


Ala Glu Val Thr Ser Ala Leu Met Phe Leu His Gln His Gly Val Ile 
        515                 520                 525             


Tyr Arg Asp Leu Lys Leu Asp Asn Ile Leu Leu Asp Ala Glu Gly His 
    530                 535                 540                 


Cys Lys Leu Ala Asp Phe Gly Met Cys Lys Glu Gly Ile Leu Asn Gly 
545                 550                 555                 560 


Val Thr Thr Thr Thr Phe Cys Gly Thr Pro Asp Tyr Ile Ala Pro Glu 
                565                 570                 575     


Ile Leu Gln Glu Leu Glu Tyr Gly Pro Ser Val Asp Trp Trp Ala Leu 
            580                 585                 590         


Gly Val Leu Met Tyr Glu Met Met Ala Gly Gln Pro Pro Phe Glu Ala 
        595                 600                 605             


Asp Asn Glu Asp Asp Leu Phe Glu Ser Ile Leu His Asp Asp Val Leu 
    610                 615                 620                 


Tyr Pro Val Trp Leu Ser Lys Glu Ala Val Ser Ile Leu Lys Ala Phe 
625                 630                 635                 640 


Met Thr Lys Asn Pro His Lys Arg Leu Gly Cys Val Ala Ser Gln Asn 
                645                 650                 655     


Gly Glu Asp Ala Ile Lys Gln His Pro Phe Phe Lys Glu Ile Asp Trp 
            660                 665                 670         


Val Leu Leu Glu Gln Lys Lys Ile Lys Pro Pro Phe Lys Pro Arg Ile 
        675                 680                 685             


Lys Thr Lys Arg Asp Val Asn Asn Phe Asp Gln Asp Phe Thr Arg Glu 
    690                 695                 700                 


Glu Pro Val Leu Thr Leu Val Asp Glu Ala Ile Val Lys Gln Ile Asn 
705                 710                 715                 720 


Gln Glu Glu Phe Lys Gly Phe Ser Tyr Phe Gly Glu Asp Leu Met Pro 
                725                 730                 735     


<210>  859
<211>  3143
<212>  DNA
<213>  Homo sapiens

<400>  859
cggagctgga gctcccaccg ccgccgcccg tgcctccggc tgccggcgcc cctgcctttg       60

gctcttcctc cccactcgcc cgctccccct ggcggagccg gcgcgcccgg ggtgccgctc      120

cctgcctggc gcgctccgca cctggaggtg ccttgcccct ctcctgccca cctcggaatt      180

tccctgtggc tcctttgatc cttcgagtct ccagctcctc tcccttccac ctgtttcccc      240

caagaaaggc aggatcctgg tccctgctac gtttctgggg ccatggctgg tctgggcccc      300

ggcgtaggcg attcagaggg gggaccccgg cccctgtttt gcagaaaggg ggccctgagg      360

cagaaggtgg tccacgaagt caagagccac aagttcaccg ctcgcttctt caagcagccc      420

accttctgca gccactgcac cgacttcatc tggggtatcg gaaagcaggg cctgcaatgt      480

caagtctgca gctttgtggt tcatcgacga tgccacgaat ttgtgacctt cgagtgtcca      540

ggcgctggga agggccccca gacggacgac ccccggaaca aacacaagtt ccgcctgcat      600

agctacagca gccccacctt ctgcgaccac tgtggctccc tcctctacgg gcttgtgcac      660

cagggcatga aatgctcctg ctgcgagatg aacgtgcacc ggcgctgtgt gcgtagcgtg      720

ccctccctgt gcggtgtgga ccacaccgag cgccgcgggc gcctgcagct ggagatccgg      780

gctcccacag cagatgagat ccacgtaact gttggcgagg cccgtaacct aattcctatg      840

gaccccaatg gtctctctga tccctatgtg aaactgaagc tcatcccaga ccctcggaac      900

ctgacgaaac agaagacccg aacggtgaaa gccacgctaa accctgtgtg gaatgagacc      960

tttgtgttca acctgaagcc aggggatgtg gagcgccggc tcagcgtgga ggtgtgggac     1020

tgggaccgga cctcccgcaa cgacttcatg ggggccatgt cctttggcgt ctcggagctg     1080

ctcaaggcgc ccgtggatgg ctggtacaag ttactgaacc aggaggaggg cgagtattac     1140

aatgtgccgg tggccgatgc tgacaactgc agcctcctcc agaagtttga ggcttgtaac     1200

taccccctgg aattgtatga gcgggtgcgg atgggcccct cttcctctcc catcccctcc     1260

ccttccccta gtcccaccga ccccaagcgc tgcttcttcg gggcgagtcc aggacgcctg     1320

cacatctccg acttcagctt cctcatggtt ctaggaaaag gcagttttgg gaaggtgatg     1380

ctggccgagc gcaggggctc tgatgagctc tacgccatca agatcttgaa aaaggacgtg     1440

atcgtccagg acgacgatgt ggactgcacg ctggtggaga aacgtgtgct ggcgctgggg     1500

ggccggggtc ctggcggccg gccccacttc ctcacccagc tccactccac cttccagacc     1560

ccggaccgcc tgtatttcgt gatggagtac gtcaccgggg gagacttgat gtaccacatt     1620

caacagctgg gcaagtttaa ggagccccat gcagcgttct acgcggcaga aatcgctatc     1680

ggcctcttct tccttcacaa tcagggcatc atctacaggg acctgaagct ggacaatgtg     1740

atgctggatg ctgagggaca catcaagatc actgactttg gcatgtgtaa ggagaacgtc     1800

ttccccggga cgacaacccg caccttctgc gggaccccgg actacatagc cccggagatc     1860

attgcctacc agccctatgg gaagtctgtc gattggtggt cctttggagt tctgctgtat     1920

gagatgttgg caggacagcc tcccttcgat ggggaggacg aggaggagct gtttcaggcc     1980

atcatggaac aaactgtcac ctaccccaag tcgctttccc gggaagccgt ggccatctgc     2040

aaggggttcc tgaccaagca cccagggaag cgcctgggct cagggcctga tggggaacct     2100

accatccgtg cacatggctt tttccgctgg attgactggg agcggctgga acgattggag     2160

atcccgcctc ctttcagacc ccgcccgtgt ggccgcagcg gcgagaactt tgacaagttc     2220

ttcacgcggg cggcgccagc gctgacccct ccagaccgcc tagtcctggc cagcatcgac     2280

caggccgatt tccagggctt cacctacgtg aaccccgact tcgtgcaccc ggatgcccgc     2340

agccccacca gcccagtgcc tgtgcccgtc atgtaatctc acccgccgcc actaggtgtc     2400

cccaacgtcc cctccgccgt gccggcggca gccccacttc acccccaact tcaccacccc     2460

ctgtcccatt ctagatcctg caccccagca ttccagctct gcccccgcgg gttctagacg     2520

cccctcccaa gcgttcctgg ccttctgaac tccatacagc ctctacagcc gtcccgcgtt     2580

caagacttga gcggagcccg atattctccc tgaccttagc gttctggact ctgccccaat     2640

cgggtccaga gaccacacca ctaaccatcc ccaactccat ggggttcgag actccatctt     2700

ggtagttctg tgcctccccc cagaccccgc ccctggggaa atagcctcac ggggttggct     2760

gttccagact caggttccag aacagccctc ggcctccgag gctccccgcc tccactctag     2820

ttctagatga gtgggaggcg tgcccccctc ctccagtacg tcccgctgct gtgctctggg     2880

gatttctggg atatatggag gattctttcc ccagaggctc ccaatcagct tttgttctag     2940

acttccccat cccgaagcca tcacttctcc ccgcagcccg cctgccgtgc atggctcctg     3000

tctggctcgg acccacccca actctcccca gtgcctgcca ctctctggga ctctcctcct     3060

cccctcctct tcccttagcc tctcccaccc ggccacagct gctggagaat aaatttggga     3120

tgctgatgaa aaaaaaaaaa aaa                                             3143


<210>  860
<211>  697
<212>  PRT
<213>  Homo sapiens

<400>  860

Met Ala Gly Leu Gly Pro Gly Val Gly Asp Ser Glu Gly Gly Pro Arg 
1               5                   10                  15      


Pro Leu Phe Cys Arg Lys Gly Ala Leu Arg Gln Lys Val Val His Glu 
            20                  25                  30          


Val Lys Ser His Lys Phe Thr Ala Arg Phe Phe Lys Gln Pro Thr Phe 
        35                  40                  45              


Cys Ser His Cys Thr Asp Phe Ile Trp Gly Ile Gly Lys Gln Gly Leu 
    50                  55                  60                  


Gln Cys Gln Val Cys Ser Phe Val Val His Arg Arg Cys His Glu Phe 
65                  70                  75                  80  


Val Thr Phe Glu Cys Pro Gly Ala Gly Lys Gly Pro Gln Thr Asp Asp 
                85                  90                  95      


Pro Arg Asn Lys His Lys Phe Arg Leu His Ser Tyr Ser Ser Pro Thr 
            100                 105                 110         


Phe Cys Asp His Cys Gly Ser Leu Leu Tyr Gly Leu Val His Gln Gly 
        115                 120                 125             


Met Lys Cys Ser Cys Cys Glu Met Asn Val His Arg Arg Cys Val Arg 
    130                 135                 140                 


Ser Val Pro Ser Leu Cys Gly Val Asp His Thr Glu Arg Arg Gly Arg 
145                 150                 155                 160 


Leu Gln Leu Glu Ile Arg Ala Pro Thr Ala Asp Glu Ile His Val Thr 
                165                 170                 175     


Val Gly Glu Ala Arg Asn Leu Ile Pro Met Asp Pro Asn Gly Leu Ser 
            180                 185                 190         


Asp Pro Tyr Val Lys Leu Lys Leu Ile Pro Asp Pro Arg Asn Leu Thr 
        195                 200                 205             


Lys Gln Lys Thr Arg Thr Val Lys Ala Thr Leu Asn Pro Val Trp Asn 
    210                 215                 220                 


Glu Thr Phe Val Phe Asn Leu Lys Pro Gly Asp Val Glu Arg Arg Leu 
225                 230                 235                 240 


Ser Val Glu Val Trp Asp Trp Asp Arg Thr Ser Arg Asn Asp Phe Met 
                245                 250                 255     


Gly Ala Met Ser Phe Gly Val Ser Glu Leu Leu Lys Ala Pro Val Asp 
            260                 265                 270         


Gly Trp Tyr Lys Leu Leu Asn Gln Glu Glu Gly Glu Tyr Tyr Asn Val 
        275                 280                 285             


Pro Val Ala Asp Ala Asp Asn Cys Ser Leu Leu Gln Lys Phe Glu Ala 
    290                 295                 300                 


Cys Asn Tyr Pro Leu Glu Leu Tyr Glu Arg Val Arg Met Gly Pro Ser 
305                 310                 315                 320 


Ser Ser Pro Ile Pro Ser Pro Ser Pro Ser Pro Thr Asp Pro Lys Arg 
                325                 330                 335     


Cys Phe Phe Gly Ala Ser Pro Gly Arg Leu His Ile Ser Asp Phe Ser 
            340                 345                 350         


Phe Leu Met Val Leu Gly Lys Gly Ser Phe Gly Lys Val Met Leu Ala 
        355                 360                 365             


Glu Arg Arg Gly Ser Asp Glu Leu Tyr Ala Ile Lys Ile Leu Lys Lys 
    370                 375                 380                 


Asp Val Ile Val Gln Asp Asp Asp Val Asp Cys Thr Leu Val Glu Lys 
385                 390                 395                 400 


Arg Val Leu Ala Leu Gly Gly Arg Gly Pro Gly Gly Arg Pro His Phe 
                405                 410                 415     


Leu Thr Gln Leu His Ser Thr Phe Gln Thr Pro Asp Arg Leu Tyr Phe 
            420                 425                 430         


Val Met Glu Tyr Val Thr Gly Gly Asp Leu Met Tyr His Ile Gln Gln 
        435                 440                 445             


Leu Gly Lys Phe Lys Glu Pro His Ala Ala Phe Tyr Ala Ala Glu Ile 
    450                 455                 460                 


Ala Ile Gly Leu Phe Phe Leu His Asn Gln Gly Ile Ile Tyr Arg Asp 
465                 470                 475                 480 


Leu Lys Leu Asp Asn Val Met Leu Asp Ala Glu Gly His Ile Lys Ile 
                485                 490                 495     


Thr Asp Phe Gly Met Cys Lys Glu Asn Val Phe Pro Gly Thr Thr Thr 
            500                 505                 510         


Arg Thr Phe Cys Gly Thr Pro Asp Tyr Ile Ala Pro Glu Ile Ile Ala 
        515                 520                 525             


Tyr Gln Pro Tyr Gly Lys Ser Val Asp Trp Trp Ser Phe Gly Val Leu 
    530                 535                 540                 


Leu Tyr Glu Met Leu Ala Gly Gln Pro Pro Phe Asp Gly Glu Asp Glu 
545                 550                 555                 560 


Glu Glu Leu Phe Gln Ala Ile Met Glu Gln Thr Val Thr Tyr Pro Lys 
                565                 570                 575     


Ser Leu Ser Arg Glu Ala Val Ala Ile Cys Lys Gly Phe Leu Thr Lys 
            580                 585                 590         


His Pro Gly Lys Arg Leu Gly Ser Gly Pro Asp Gly Glu Pro Thr Ile 
        595                 600                 605             


Arg Ala His Gly Phe Phe Arg Trp Ile Asp Trp Glu Arg Leu Glu Arg 
    610                 615                 620                 


Leu Glu Ile Pro Pro Pro Phe Arg Pro Arg Pro Cys Gly Arg Ser Gly 
625                 630                 635                 640 


Glu Asn Phe Asp Lys Phe Phe Thr Arg Ala Ala Pro Ala Leu Thr Pro 
                645                 650                 655     


Pro Asp Arg Leu Val Leu Ala Ser Ile Asp Gln Ala Asp Phe Gln Gly 
            660                 665                 670         


Phe Thr Tyr Val Asn Pro Asp Phe Val His Pro Asp Ala Arg Ser Pro 
        675                 680                 685             


Thr Ser Pro Val Pro Val Pro Val Met 
    690                 695         


<210>  861
<211>  697
<212>  PRT
<213>  Homo sapiens

<400>  861

Met Ala Gly Leu Gly Pro Gly Val Gly Asp Ser Glu Gly Gly Pro Arg 
1               5                   10                  15      


Pro Leu Phe Cys Arg Lys Gly Ala Leu Arg Gln Lys Val Val His Glu 
            20                  25                  30          


Val Lys Ser His Lys Phe Thr Ala Arg Phe Phe Lys Gln Pro Thr Phe 
        35                  40                  45              


Cys Ser His Cys Thr Asp Phe Ile Trp Gly Ile Gly Lys Gln Gly Leu 
    50                  55                  60                  


Gln Cys Gln Val Cys Ser Phe Val Val His Arg Arg Cys His Glu Phe 
65                  70                  75                  80  


Val Thr Phe Glu Cys Pro Gly Ala Gly Lys Gly Pro Gln Thr Asp Asp 
                85                  90                  95      


Pro Arg Asn Lys His Lys Phe Arg Leu His Ser Tyr Ser Ser Pro Thr 
            100                 105                 110         


Phe Cys Asp His Cys Gly Ser Leu Leu Tyr Gly Leu Val His Gln Gly 
        115                 120                 125             


Met Lys Cys Ser Cys Cys Glu Met Asn Val His Arg Arg Cys Val Arg 
    130                 135                 140                 


Ser Val Pro Ser Leu Cys Gly Val Asp His Thr Glu Arg Arg Gly Arg 
145                 150                 155                 160 


Leu Gln Leu Glu Ile Arg Ala Pro Thr Ala Asp Glu Ile His Val Thr 
                165                 170                 175     


Val Gly Glu Ala Arg Asn Leu Ile Pro Met Asp Pro Asn Gly Leu Ser 
            180                 185                 190         


Asp Pro Tyr Val Lys Leu Lys Leu Ile Pro Asp Pro Arg Asn Leu Thr 
        195                 200                 205             


Lys Gln Lys Thr Arg Thr Val Lys Ala Thr Leu Asn Pro Val Trp Asn 
    210                 215                 220                 


Glu Thr Phe Val Phe Asn Leu Lys Pro Gly Asp Val Glu Arg Arg Leu 
225                 230                 235                 240 


Ser Val Glu Val Trp Asp Trp Asp Arg Thr Ser Arg Asn Asp Phe Met 
                245                 250                 255     


Gly Ala Met Ser Phe Gly Val Ser Glu Leu Leu Lys Ala Pro Val Asp 
            260                 265                 270         


Gly Trp Tyr Lys Leu Leu Asn Gln Glu Glu Gly Glu Tyr Tyr Asn Val 
        275                 280                 285             


Pro Val Ala Asp Ala Asp Asn Cys Ser Leu Leu Gln Lys Phe Glu Ala 
    290                 295                 300                 


Cys Asn Tyr Pro Leu Glu Leu Tyr Glu Arg Val Arg Met Gly Pro Ser 
305                 310                 315                 320 


Ser Ser Pro Ile Pro Ser Pro Ser Pro Ser Pro Thr Asp Pro Lys Arg 
                325                 330                 335     


Cys Phe Phe Gly Ala Ser Pro Gly Arg Leu His Ile Ser Asp Phe Ser 
            340                 345                 350         


Phe Leu Met Val Leu Gly Lys Gly Ser Phe Gly Lys Val Met Leu Ala 
        355                 360                 365             


Glu Arg Arg Gly Ser Asp Glu Leu Tyr Ala Ile Lys Ile Leu Lys Lys 
    370                 375                 380                 


Asp Val Ile Val Gln Asp Asp Asp Val Asp Cys Thr Leu Val Glu Lys 
385                 390                 395                 400 


Arg Val Leu Ala Leu Gly Gly Arg Gly Pro Gly Gly Arg Pro His Phe 
                405                 410                 415     


Leu Thr Gln Leu His Ser Thr Phe Gln Thr Pro Asp Arg Leu Tyr Phe 
            420                 425                 430         


Val Met Glu Tyr Val Thr Gly Gly Asp Leu Met Tyr His Ile Gln Gln 
        435                 440                 445             


Leu Gly Lys Phe Lys Glu Pro His Ala Ala Phe Tyr Ala Ala Glu Ile 
    450                 455                 460                 


Ala Ile Gly Leu Phe Phe Leu His Asn Gln Gly Ile Ile Tyr Arg Asp 
465                 470                 475                 480 


Leu Lys Leu Asp Asn Val Met Leu Asp Ala Glu Gly His Ile Lys Ile 
                485                 490                 495     


Thr Asp Phe Gly Met Cys Lys Glu Asn Val Phe Pro Gly Thr Thr Thr 
            500                 505                 510         


Arg Thr Phe Cys Gly Thr Pro Asp Tyr Ile Ala Pro Glu Ile Ile Ala 
        515                 520                 525             


Tyr Gln Pro Tyr Gly Lys Ser Val Asp Trp Trp Ser Phe Gly Val Leu 
    530                 535                 540                 


Leu Tyr Glu Met Leu Ala Gly Gln Pro Pro Phe Asp Gly Glu Asp Glu 
545                 550                 555                 560 


Glu Glu Leu Phe Gln Ala Ile Met Glu Gln Thr Val Thr Tyr Pro Lys 
                565                 570                 575     


Ser Leu Ser Arg Glu Ala Val Ala Ile Cys Lys Gly Phe Leu Thr Lys 
            580                 585                 590         


His Pro Gly Lys Arg Leu Gly Ser Gly Pro Asp Gly Glu Pro Thr Ile 
        595                 600                 605             


Arg Ala His Gly Phe Phe Arg Trp Ile Asp Trp Glu Arg Leu Glu Arg 
    610                 615                 620                 


Leu Glu Ile Pro Pro Pro Phe Arg Pro Arg Pro Cys Gly Arg Ser Gly 
625                 630                 635                 640 


Glu Asn Phe Asp Lys Phe Phe Thr Arg Ala Ala Pro Ala Leu Thr Pro 
                645                 650                 655     


Pro Asp Arg Leu Val Leu Ala Ser Ile Asp Gln Ala Asp Phe Gln Gly 
            660                 665                 670         


Phe Thr Tyr Val Asn Pro Asp Phe Val His Pro Asp Ala Arg Ser Pro 
        675                 680                 685             


Thr Ser Pro Val Pro Val Pro Val Met 
    690                 695         


<210>  862
<211>  3522
<212>  DNA
<213>  Homo sapiens

<400>  862
aggggcgagt cctgcgcgag tccccgggag gcgccgcgcg cttggaaggg acggtcgggc       60

ttccccggcc cgctgagggc tcggcggcgg gctcccctcc tttccacctc gggagggagg      120

gaaggagggg agggaaaagt cccacggagg aggcagaatg gccagtcgag gggcgcttag      180

gcgctgcctt tccccagggc tgcctcgact cctgcacctg tcccgagggc tggcctgaga      240

cgggactccc ggttctcccg ctgcgaagca gcgcggcccc ccggggccgg ggcagcggcg      300

ccggcatgtc gtctggcacc atgaagttca atggctattt gagggtccgc atcggtgagg      360

cagtggggct gcagcccacc cgctggtccc tgcgccactc gctcttcaag aagggccacc      420

agctgctgga cccctatctg acggtgagcg tggaccaggt gcgcgtgggc cagaccagca      480

ccaagcagaa gaccaacaaa cccacgtaca acgaggagtt ttgcgctaac gtcaccgacg      540

gcggccacct cgagttggcc gtcttccacg agacgcccct gggctacgac cacttcgtgg      600

ccaactgcac cctgcagttc caggagctgc tgcgcacgac cggcgcctcg gacaccttcg      660

agggttgggt ggatctcgag ccagagggga aagtatttgt ggtaataacc cttaccggga      720

gtttcactga agctactctc cagagagacc ggatcttcaa acattttacc aggaagcgcc      780

aaagggctat gcgaaggcga gtccaccaga tcaatggaca caagttcatg gccacgtatc      840

tgaggcagcc cacctactgc tctcactgca gggagtttat ctggggagtg tttgggaaac      900

agggttatca gtgccaagtg tgcacctgtg tcgtccataa acgctgccat catctaattg      960

ttacagcctg tacttgccaa aacaatatta acaaagtgga ttcaaagatt gcagaacaga     1020

ggttcgggat caacatccca cacaagttca gcatccacaa ctacaaagtg ccaacattct     1080

gcgatcactg tggctcactg ctctggggaa taatgcgaca aggacttcag tgtaaaatat     1140

gtaaaatgaa tgtgcatatt cgatgtcaag cgaacgtggc ccctaactgt ggggtaaatg     1200

cggtggaact tgccaagacc ctggcaggga tgggtctcca acccggaaat atttctccaa     1260

cctcgaaact cgtttccaga tcgaccctaa gacgacaggg aaaggagagc agcaaagaag     1320

gaaatgggat tggggttaat tcttccaacc gacttggtat cgacaacttt gagttcatcc     1380

gagtgttggg gaaggggagt tttgggaagg tgatgcttgc aagagtaaaa gaaacaggag     1440

acctctatgc tgtgaaggtg ctgaagaagg acgtgattct gcaggatgat gatgtggaat     1500

gcaccatgac cgagaaaagg atcctgtctc tggcccgcaa tcaccccttc ctcactcagt     1560

tgttctgctg ctttcagacc cccgatcgtc tgttttttgt gatggagttt gtgaatgggg     1620

gtgacttgat gttccacatt cagaagtctc gtcgttttga tgaagcacga gctcgcttct     1680

atgctgcaga aatcatttcg gctctcatgt tcctccatga taaaggaatc atctatagag     1740

atctgaaact ggacaatgtc ctgttggacc acgagggtca ctgtaaactg gcagacttcg     1800

gaatgtgcaa ggaggggatt tgcaatggtg tcaccacggc cacattctgt ggcacgccag     1860

actatatcgc tccagagatc ctccaggaaa tgctgtacgg gcctgcagta gactggtggg     1920

caatgggcgt gttgctctat gagatgctct gtggtcacgc gccttttgag gcagagaacg     1980

aagatgacct ctttgaggcc atactgaatg atgaggtggt ctaccctacc tggctccatg     2040

aagatgccac agggatccta aaatctttca tgaccaagaa ccccaccatg cgcttgggca     2100

gcctgactca gggaggcgag cacgccatct tgagacatcc tttttttaag gaaatcgact     2160

gggcccagct gaaccatcgc caaatagaac cgcctttcag acccagaatc aaatcccgag     2220

aagatgtcag taattttgac cctgacttca taaaggaaga gccagtttta actccaattg     2280

atgagggaca tcttccaatg attaaccagg atgagtttag aaacttttcc tatgtgtctc     2340

cagaattgca accatagcct tatggggagt gagagagagg gcacgagaac ccaaagggaa     2400

tagagattct ccaggaattt cctctatggg accttcccag catcagcctt agaacaagaa     2460

ccttaccttc aaggagcaag tgaagaactc tgtgaaggat ggaactttca gatatcaact     2520

atttagagtc cagagggagc catggcacta gaaatagttg ataatgaaat gagattttat     2580

gaagtatacc gctccaccta tgagcgtctg tctctgtggg cttgggatgt taacaggagc     2640

caaaaggagg gaaagtgtga agaataaagt agatctgaga aattctgagc caatcaggct     2700

tcttaattca agagacaaac caagacgttc tgtcaactgt gctgtgctct tctttaagcc     2760

aatgaacccc aattcctggc agtctacaag aagtctctta atgctaatga agaatttaaa     2820

ggtcttttta aggaaatgaa gggctttcca aatagaatga tttactctga agaaacaaac     2880

aatggtatct ctgaaactca caacctaaag cccaatcttg aaaatatgtt gtgcaccaag     2940

acgactgctt cagcttcttc tcttatcctt actttcttta atagatattt attaaactgt     3000

ccagtgaaaa ggtgccacaa tgcccagtat tgtaaacaac aggtttgcat tcatgaagct     3060

ttcattcatt ctggagtcta ctaatttacc tgaatggtgt ttgcattctg tgaaatgcct     3120

ctccacgttg catatgtcac acttttgtct gcacataact cttttttcac aagaagggtc     3180

actgccacaa cagcacagtc agcgggtgaa ttacaggtgc ctgctgcctg cctacctggg     3240

taatctgatc ttgtctgtat cgccgtgtgc tcatcactga agaattgcag gccactcatg     3300

tcagtgacca gatttgtggc ttataaacat tagcagttta tttatgtttt aagatgcaaa     3360

gatgtgtgtt tgatattcac tttaataatt agaaatggat cttgtaaaca gggcatatat     3420

caaagatgac cttataatat gtacccgaat atacagttca agaattttgt ctgactggaa     3480

ataaatgcat tttgtagcaa aaggaaaaaa aaaaaaaaaa aa                        3522


<210>  863
<211>  683
<212>  PRT
<213>  Homo sapiens

<400>  863

Met Ser Ser Gly Thr Met Lys Phe Asn Gly Tyr Leu Arg Val Arg Ile 
1               5                   10                  15      


Gly Glu Ala Val Gly Leu Gln Pro Thr Arg Trp Ser Leu Arg His Ser 
            20                  25                  30          


Leu Phe Lys Lys Gly His Gln Leu Leu Asp Pro Tyr Leu Thr Val Ser 
        35                  40                  45              


Val Asp Gln Val Arg Val Gly Gln Thr Ser Thr Lys Gln Lys Thr Asn 
    50                  55                  60                  


Lys Pro Thr Tyr Asn Glu Glu Phe Cys Ala Asn Val Thr Asp Gly Gly 
65                  70                  75                  80  


His Leu Glu Leu Ala Val Phe His Glu Thr Pro Leu Gly Tyr Asp His 
                85                  90                  95      


Phe Val Ala Asn Cys Thr Leu Gln Phe Gln Glu Leu Leu Arg Thr Thr 
            100                 105                 110         


Gly Ala Ser Asp Thr Phe Glu Gly Trp Val Asp Leu Glu Pro Glu Gly 
        115                 120                 125             


Lys Val Phe Val Val Ile Thr Leu Thr Gly Ser Phe Thr Glu Ala Thr 
    130                 135                 140                 


Leu Gln Arg Asp Arg Ile Phe Lys His Phe Thr Arg Lys Arg Gln Arg 
145                 150                 155                 160 


Ala Met Arg Arg Arg Val His Gln Ile Asn Gly His Lys Phe Met Ala 
                165                 170                 175     


Thr Tyr Leu Arg Gln Pro Thr Tyr Cys Ser His Cys Arg Glu Phe Ile 
            180                 185                 190         


Trp Gly Val Phe Gly Lys Gln Gly Tyr Gln Cys Gln Val Cys Thr Cys 
        195                 200                 205             


Val Val His Lys Arg Cys His His Leu Ile Val Thr Ala Cys Thr Cys 
    210                 215                 220                 


Gln Asn Asn Ile Asn Lys Val Asp Ser Lys Ile Ala Glu Gln Arg Phe 
225                 230                 235                 240 


Gly Ile Asn Ile Pro His Lys Phe Ser Ile His Asn Tyr Lys Val Pro 
                245                 250                 255     


Thr Phe Cys Asp His Cys Gly Ser Leu Leu Trp Gly Ile Met Arg Gln 
            260                 265                 270         


Gly Leu Gln Cys Lys Ile Cys Lys Met Asn Val His Ile Arg Cys Gln 
        275                 280                 285             


Ala Asn Val Ala Pro Asn Cys Gly Val Asn Ala Val Glu Leu Ala Lys 
    290                 295                 300                 


Thr Leu Ala Gly Met Gly Leu Gln Pro Gly Asn Ile Ser Pro Thr Ser 
305                 310                 315                 320 


Lys Leu Val Ser Arg Ser Thr Leu Arg Arg Gln Gly Lys Glu Ser Ser 
                325                 330                 335     


Lys Glu Gly Asn Gly Ile Gly Val Asn Ser Ser Asn Arg Leu Gly Ile 
            340                 345                 350         


Asp Asn Phe Glu Phe Ile Arg Val Leu Gly Lys Gly Ser Phe Gly Lys 
        355                 360                 365             


Val Met Leu Ala Arg Val Lys Glu Thr Gly Asp Leu Tyr Ala Val Lys 
    370                 375                 380                 


Val Leu Lys Lys Asp Val Ile Leu Gln Asp Asp Asp Val Glu Cys Thr 
385                 390                 395                 400 


Met Thr Glu Lys Arg Ile Leu Ser Leu Ala Arg Asn His Pro Phe Leu 
                405                 410                 415     


Thr Gln Leu Phe Cys Cys Phe Gln Thr Pro Asp Arg Leu Phe Phe Val 
            420                 425                 430         


Met Glu Phe Val Asn Gly Gly Asp Leu Met Phe His Ile Gln Lys Ser 
        435                 440                 445             


Arg Arg Phe Asp Glu Ala Arg Ala Arg Phe Tyr Ala Ala Glu Ile Ile 
    450                 455                 460                 


Ser Ala Leu Met Phe Leu His Asp Lys Gly Ile Ile Tyr Arg Asp Leu 
465                 470                 475                 480 


Lys Leu Asp Asn Val Leu Leu Asp His Glu Gly His Cys Lys Leu Ala 
                485                 490                 495     


Asp Phe Gly Met Cys Lys Glu Gly Ile Cys Asn Gly Val Thr Thr Ala 
            500                 505                 510         


Thr Phe Cys Gly Thr Pro Asp Tyr Ile Ala Pro Glu Ile Leu Gln Glu 
        515                 520                 525             


Met Leu Tyr Gly Pro Ala Val Asp Trp Trp Ala Met Gly Val Leu Leu 
    530                 535                 540                 


Tyr Glu Met Leu Cys Gly His Ala Pro Phe Glu Ala Glu Asn Glu Asp 
545                 550                 555                 560 


Asp Leu Phe Glu Ala Ile Leu Asn Asp Glu Val Val Tyr Pro Thr Trp 
                565                 570                 575     


Leu His Glu Asp Ala Thr Gly Ile Leu Lys Ser Phe Met Thr Lys Asn 
            580                 585                 590         


Pro Thr Met Arg Leu Gly Ser Leu Thr Gln Gly Gly Glu His Ala Ile 
        595                 600                 605             


Leu Arg His Pro Phe Phe Lys Glu Ile Asp Trp Ala Gln Leu Asn His 
    610                 615                 620                 


Arg Gln Ile Glu Pro Pro Phe Arg Pro Arg Ile Lys Ser Arg Glu Asp 
625                 630                 635                 640 


Val Ser Asn Phe Asp Pro Asp Phe Ile Lys Glu Glu Pro Val Leu Thr 
                645                 650                 655     


Pro Ile Asp Glu Gly His Leu Pro Met Ile Asn Gln Asp Glu Phe Arg 
            660                 665                 670         


Asn Phe Ser Tyr Val Ser Pro Glu Leu Gln Pro 
        675                 680             


<210>  864
<211>  682
<212>  PRT
<213>  Homo sapiens

<400>  864

Met Ser Ser Gly Thr Met Lys Phe Asn Gly Tyr Leu Arg Val Cys Ile 
1               5                   10                  15      


Gly Glu Ala Val Gly Leu Gln Pro Thr Arg Trp Ser Leu Arg His Ser 
            20                  25                  30          


Leu Phe Lys Lys Gly His Gln Leu Leu Asp Pro Tyr Leu Thr Val Ser 
        35                  40                  45              


Val Asp Gln Val Arg Val Gly Gln Thr Ser Thr Lys Gln Lys Thr Asn 
    50                  55                  60                  


Lys Pro Thr Tyr Asn Glu Glu Phe Cys Ala Asn Val Thr Asp Gly Gly 
65                  70                  75                  80  


His Leu Glu Leu Ala Val Phe His Glu Thr Pro Leu Gly Tyr Asp His 
                85                  90                  95      


Phe Val Ala Asn Cys Thr Leu Gln Phe Gln Glu Leu Leu Arg Thr Thr 
            100                 105                 110         


Gly Ala Ser Asp Thr Phe Glu Gly Trp Val Asp Leu Glu Pro Glu Gly 
        115                 120                 125             


Lys Val Phe Val Val Ile Thr Leu Thr Gly Ser Phe Thr Glu Ala Thr 
    130                 135                 140                 


Leu Gln Arg Asp Arg Ile Phe Lys His Phe Thr Arg Lys Arg Gln Arg 
145                 150                 155                 160 


Ala Met Arg Arg Val His Gln Ile Asn Gly His Lys Phe Met Ala Thr 
                165                 170                 175     


Tyr Leu Arg Gln Pro Thr Tyr Cys Ser His Cys Arg Glu Phe Ile Trp 
            180                 185                 190         


Gly Val Phe Gly Lys Gln Gly Tyr Gln Cys Gln Val Cys Thr Cys Val 
        195                 200                 205             


Val His Lys Arg Cys His His Leu Ile Val Thr Ala Cys Thr Cys Gln 
    210                 215                 220                 


Tyr Asn Ile Asn Lys Val Asp Ser Lys Ile Ala Glu Gln Arg Phe Gly 
225                 230                 235                 240 


Ile Asn Ile Pro His Lys Phe Ser Ile His Asn Tyr Lys Val Pro Thr 
                245                 250                 255     


Phe Cys Asp His Cys Gly Ser Leu Leu Trp Gly Ile Met Arg Gln Gly 
            260                 265                 270         


Leu Gln Cys Lys Ile Cys Lys Met Asn Val His Ile Arg Cys Gln Ala 
        275                 280                 285             


Asn Val Ala Pro Asn Cys Gly Val Asn Ala Val Glu Leu Ala Lys Thr 
    290                 295                 300                 


Leu Ala Gly Met Gly Leu Gln Pro Gly Asn Ile Ser Pro Thr Ser Lys 
305                 310                 315                 320 


Leu Val Ser Arg Ser Thr Leu Arg Arg Gln Gly Lys Glu Ser Ser Lys 
                325                 330                 335     


Glu Gly Asn Gly Ile Gly Val Asn Ser Ser Asn Arg Leu Gly Ile Asp 
            340                 345                 350         


Asn Phe Glu Phe Ile Arg Val Leu Gly Lys Gly Ser Phe Gly Lys Val 
        355                 360                 365             


Met Leu Ala Arg Val Lys Glu Thr Gly Asp Leu Tyr Ala Val Lys Val 
    370                 375                 380                 


Leu Lys Lys Asp Val Ile Leu Gln Asp Asp Asp Val Glu Cys Thr Met 
385                 390                 395                 400 


Thr Glu Lys Arg Ile Leu Ser Leu Ala Arg Asn His Pro Phe Leu Thr 
                405                 410                 415     


Gln Leu Phe Cys Cys Phe Gln Thr Pro Asp Arg Leu Phe Phe Val Met 
            420                 425                 430         


Glu Phe Val Asn Gly Gly Asp Leu Met Phe His Ile Gln Lys Ser Arg 
        435                 440                 445             


Arg Phe Asp Glu Ala Arg Ala Arg Phe Tyr Ala Ala Glu Ile Ile Ser 
    450                 455                 460                 


Ala Leu Met Phe Leu His Asp Lys Gly Ile Ile Tyr Arg Asp Leu Lys 
465                 470                 475                 480 


Leu Asp Asn Val Leu Leu Asp His Glu Gly His Cys Lys Leu Ala Asp 
                485                 490                 495     


Phe Gly Met Cys Lys Glu Gly Ile Cys Asn Gly Val Thr Thr Ala Thr 
            500                 505                 510         


Phe Cys Gly Thr Pro Asp Tyr Ile Ala Pro Glu Ile Leu Gln Glu Met 
        515                 520                 525             


Leu Tyr Gly Pro Ala Val Asp Trp Trp Ala Met Gly Val Leu Leu Tyr 
    530                 535                 540                 


Glu Met Leu Cys Gly His Ala Pro Phe Glu Ala Glu Asn Glu Asp Asp 
545                 550                 555                 560 


Leu Phe Glu Ala Ile Leu Asn Asp Glu Val Val Tyr Pro Thr Trp Leu 
                565                 570                 575     


His Glu Asp Ala Thr Gly Ile Leu Lys Ser Phe Met Thr Lys Asn Pro 
            580                 585                 590         


Thr Met Arg Leu Gly Ser Leu Thr Gln Gly Gly Glu His Ala Ile Leu 
        595                 600                 605             


Arg His Pro Phe Phe Lys Glu Ile Asp Trp Ala Gln Leu Asn His Arg 
    610                 615                 620                 


Gln Ile Glu Pro Pro Phe Arg Pro Arg Ile Lys Ser Arg Glu Asp Val 
625                 630                 635                 640 


Ser Asn Phe Asp Pro Asp Phe Ile Lys Glu Glu Pro Val Leu Thr Pro 
                645                 650                 655     


Ile Asp Glu Gly His Leu Pro Met Ile Asn Gln Asp Glu Phe Arg Asn 
            660                 665                 670         


Phe Ser Tyr Val Ser Pro Glu Leu Gln Pro 
        675                 680         


<210>  865
<211>  4884
<212>  DNA
<213>  Homo sapiens

<400>  865
aggtgtcttg ggcccgggcg gctgtagagg cggcggcgcc tacgggcagt gggaggagcc       60

gcgcggttcc ggctgctccg gcgaggcgac ccttgggtcg gcgctgcggg cgaggtgggc      120

aggtaggtgg gcggacggcc gcggttctcc ggcaagcgca ggcggcggag tcccccacgg      180

cgcccgaagc gcccccccgc acccccggcc tccagcgttg aggcggggga gtgaggagat      240

gccgacccag agggacagca gcaccatgtc ccacacggtc gcaggcggcg gcagcgggga      300

ccattcccac caggtccggg tgaaagccta ctaccgcggg gatatcatga taacacattt      360

tgaaccttcc atctcctttg agggcctttg caatgaggtt cgagacatgt gttcttttga      420

caacgaacag ctcttcacca tgaaatggat agatgaggaa ggagacccgt gtacagtatc      480

atctcagttg gagttagaag aagcctttag actttatgag ctaaacaagg attctgaact      540

cttgattcat gtgttccctt gtgtaccaga acgtcctggg atgccttgtc caggagaaga      600

taaatccatc taccgtagag gtgcacgccg ctggagaaag ctttattgtg ccaatggcca      660

cactttccaa gccaagcgtt tcaacaggcg tgctcactgt gccatctgca cagaccgaat      720

atggggactt ggacgccaag gatataagtg catcaactgc aaactcttgg ttcataagaa      780

gtgccataaa ctcgtcacaa ttgaatgtgg gcggcattct ttgccacagg aaccagtgat      840

gcccatggat cagtcatcca tgcattctga ccatgcacag acagtaattc catataatcc      900

ttcaagtcat gagagtttgg atcaagttgg tgaagaaaaa gaggcaatga acaccaggga      960

aagtggcaaa gcttcatcca gtctaggtct tcaggatttt gatttgctcc gggtaatagg     1020

aagaggaagt tatgccaaag tactgttggt tcgattaaaa aaaacagatc gtatttatgc     1080

aatgaaagtt gtgaaaaaag agcttgttaa tgatgatgag gatattgatt gggtacagac     1140

agagaagcat gtgtttgagc aggcatccaa tcatcctttc cttgttgggc tgcattcttg     1200

ctttcagaca gaaagcagat tgttctttgt tatagagtat gtaaatggag gagacctaat     1260

gtttcatatg cagcgacaaa gaaaacttcc tgaagaacat gccagatttt actctgcaga     1320

aatcagtcta gcattaaatt atcttcatga gcgagggata atttatagag atttgaaact     1380

ggacaatgta ttactggact ctgaaggcca cattaaactc actgactacg gcatgtgtaa     1440

ggaaggatta cggccaggag atacaaccag cactttctgt ggtactccta attacattgc     1500

tcctgaaatt ttaagaggag aagattatgg tttcagtgtt gactggtggg ctcttggagt     1560

gctcatgttt gagatgatgg caggaaggtc tccatttgat attgttggga gctccgataa     1620

ccctgaccag aacacagagg attatctctt ccaagttatt ttggaaaaac aaattcgcat     1680

accacgttct ctgtctgtaa aagctgcaag tgttctgaag agttttctta ataaggaccc     1740

taaggaacga ttgggttgtc atcctcaaac aggatttgct gatattcagg gacacccgtt     1800

cttccgaaat gttgattggg atatgatgga gcaaaaacag gtggtacctc cctttaaacc     1860

aaatatttct ggggaatttg gtttggacaa ctttgattct cagtttacta atgaacctgt     1920

ccagctcact ccagatgacg atgacattgt gaggaagatt gatcagtctg aatttgaagg     1980

ttttgagtat atcaatcctc ttttgatgtc tgcagaagaa tgtgtctgat cctcattttt     2040

caaccatgta ttctactcat gttgccattt aatgcatgga taaacttgct gcaagcctgg     2100

atacaattaa ccattttata tttgccacct acaaaaaaac acccaatatc ttctcttgta     2160

gactatatga atcaattatt acatctgttt tactatgaaa aaaaaattaa tactactagc     2220

ttccagacaa tcatgtcaaa atttagttga actggttttt cagtttttaa aaggcctaca     2280

gatgagtaat gaagttatct tttttgttta aaaaaaaaaa aaacactgca ttaaaaaagt     2340

atctgttgca ttaaggcaca tagtgggatt acatcataaa cctcccataa tttttgtcat     2400

tctgtgttaa atcatttcag ggtttaattt tgaaataaaa gattaatata aaatgcaaca     2460

actttttata ttacctatta gttttggagt tctttatgtt taaaaattca ggtgtaaatt     2520

ttattgcctt ggataaataa attattgatc ttttttaagg cagcagttat taaattggta     2580

atagaagatg ctgcttgctt agaattggga aattcggctg ggtgcagtga ctcaatgcct     2640

gtgatcccag tactttggga ggttgaggcg ggcagatcac ttgaggtcag gagtttgaga     2700

ttggcctggt caacatggtg aaatcctgtc tctactaaaa atacaaaaat tagctgggca     2760

tggtggcaca tacctgtaat cccagctact cgggaggctg aaacaggaga atcgcttgaa     2820

cccaggagat ggagttggca gtgagccaag attagcctgg gcaacagtga gtgagactcg     2880

gtctcaaaca aaaaccaaat tgggaaattc ttcttgagtt aaaaaagaca ctttttatta     2940

tgaatcagat tccaaatcat taactatttt tgcaaaactg gcacaagtgg tttttctttt     3000

taagtatatt aacagggtag ctcctgagcc tttcccttta ttggaaactt taactgcagt     3060

gttaatatat acactgcaaa agaccaagga tgcagttgaa tggaaaatta ctcagtgtat     3120

agaaaggaaa aaaaccagaa atttaaaata gatacagaaa agtacactgg taatattttt     3180

atttcctatt ggagagtgaa tccccacagt tgctttttgt gacttgattc aaatgaggca     3240

ctcattattg ttaccaaact tgtaaaagca ttccatgtat tcagtggagg cagaatgtat     3300

aatatttttt ccttataatt tagcatacag gaaaagtatt tattttttaa gtagggtatc     3360

ttaattatgc tcatttcttc ccctaaacca cattatctat atgattggac cctttagtga     3420

aatcagaaaa ataaagtagg catgaataaa tgttcaggac acacacatac actcacacac     3480

atcacagtat cagctctttc agtgagtttt tattaactag ataacacatg taatacatag     3540

tagaatacat ttcagaggca gagttcctcg gattattttt tatggatatt agtgttcagc     3600

agcttattat ttaaaggggt gccaaatata gcatccttct gttgtttatt ttaaatatat     3660

ttttaatgaa aagggactta aaaagtaaac atgattatct aaattactta aaatttttta     3720

atcttagtaa aaattttagg aaagttatct agtttaaatt tcaaatgttt taaaatttgt     3780

aggcatttaa taaattatct ttttttggag gggtggatgc tgcatttcat tggaaatgtc     3840

atttttccaa agtttctagc tatatactct ctttccttca aataacataa gtctgaaagc     3900

aatgaaaacg tcaaaggaaa atgtttatat acatccacat gtttatttaa tatgtttctc     3960

ttaacacctg aaacttgttt taaaacaaaa agcagtattc acttcaaatc ataaacttag     4020

aattctgtat ctcatgtcag aaatatgttt atggccttgc ttttaagtgg tgctgtttcc     4080

catagggcat tagttctcag attttggaat gtgaaataat cacctaggaa gttggtttaa     4140

aatgcacact agtgagccca ccttagactt cttttggggc cttcgacctc actttgagaa     4200

ataccttctt caggttattc tttatgtttg tcctgtggtt aaatattaga gtattcatga     4260

taaaacattt tgagaagggg taagcagtga gttattaccc acaatttaaa gcaaattttg     4320

aatgaatctt taagttaggt atctaccttc ccaccagccc cccaaaaaac ctctcagtag     4380

tttctttcag tgtacaaaat gatgagcatt tttctatgat gaggttttaa ccattattca     4440

gggtggtctt ttgtttttaa atcttttttt aactaataag atttacggtg tgtattttat     4500

acagaaatgc attataaatg tttttaattg tgttctgttt tttgcagtct ttaagtgcca     4560

tgccaattgt tcttatattc tatagaagtt cgctcaaaat actcaacagg ggaataggca     4620

gcggacagtc agaatggttg gaattttggc tttctaagaa aaactttatt ttgcataagc     4680

atgtggtcag atcattttgt gcatatgcag cctggattgg atgttaagta aatgcttgtt     4740

cagtgccggt acatttactt aaatctgttt ttatttttgt catgtagaat actactgtgg     4800

tcatcataat gtaatctatt tctgtacctt tttttttttt ttttactttg aagtctttaa     4860

ataaaatgta taatacccat tgag                                            4884


<210>  866
<211>  596
<212>  PRT
<213>  Homo sapiens

<400>  866

Met Pro Thr Gln Arg Asp Ser Ser Thr Met Ser His Thr Val Ala Gly 
1               5                   10                  15      


Gly Gly Ser Gly Asp His Ser His Gln Val Arg Val Lys Ala Tyr Tyr 
            20                  25                  30          


Arg Gly Asp Ile Met Ile Thr His Phe Glu Pro Ser Ile Ser Phe Glu 
        35                  40                  45              


Gly Leu Cys Asn Glu Val Arg Asp Met Cys Ser Phe Asp Asn Glu Gln 
    50                  55                  60                  


Leu Phe Thr Met Lys Trp Ile Asp Glu Glu Gly Asp Pro Cys Thr Val 
65                  70                  75                  80  


Ser Ser Gln Leu Glu Leu Glu Glu Ala Phe Arg Leu Tyr Glu Leu Asn 
                85                  90                  95      


Lys Asp Ser Glu Leu Leu Ile His Val Phe Pro Cys Val Pro Glu Arg 
            100                 105                 110         


Pro Gly Met Pro Cys Pro Gly Glu Asp Lys Ser Ile Tyr Arg Arg Gly 
        115                 120                 125             


Ala Arg Arg Trp Arg Lys Leu Tyr Cys Ala Asn Gly His Thr Phe Gln 
    130                 135                 140                 


Ala Lys Arg Phe Asn Arg Arg Ala His Cys Ala Ile Cys Thr Asp Arg 
145                 150                 155                 160 


Ile Trp Gly Leu Gly Arg Gln Gly Tyr Lys Cys Ile Asn Cys Lys Leu 
                165                 170                 175     


Leu Val His Lys Lys Cys His Lys Leu Val Thr Ile Glu Cys Gly Arg 
            180                 185                 190         


His Ser Leu Pro Gln Glu Pro Val Met Pro Met Asp Gln Ser Ser Met 
        195                 200                 205             


His Ser Asp His Ala Gln Thr Val Ile Pro Tyr Asn Pro Ser Ser His 
    210                 215                 220                 


Glu Ser Leu Asp Gln Val Gly Glu Glu Lys Glu Ala Met Asn Thr Arg 
225                 230                 235                 240 


Glu Ser Gly Lys Ala Ser Ser Ser Leu Gly Leu Gln Asp Phe Asp Leu 
                245                 250                 255     


Leu Arg Val Ile Gly Arg Gly Ser Tyr Ala Lys Val Leu Leu Val Arg 
            260                 265                 270         


Leu Lys Lys Thr Asp Arg Ile Tyr Ala Met Lys Val Val Lys Lys Glu 
        275                 280                 285             


Leu Val Asn Asp Asp Glu Asp Ile Asp Trp Val Gln Thr Glu Lys His 
    290                 295                 300                 


Val Phe Glu Gln Ala Ser Asn His Pro Phe Leu Val Gly Leu His Ser 
305                 310                 315                 320 


Cys Phe Gln Thr Glu Ser Arg Leu Phe Phe Val Ile Glu Tyr Val Asn 
                325                 330                 335     


Gly Gly Asp Leu Met Phe His Met Gln Arg Gln Arg Lys Leu Pro Glu 
            340                 345                 350         


Glu His Ala Arg Phe Tyr Ser Ala Glu Ile Ser Leu Ala Leu Asn Tyr 
        355                 360                 365             


Leu His Glu Arg Gly Ile Ile Tyr Arg Asp Leu Lys Leu Asp Asn Val 
    370                 375                 380                 


Leu Leu Asp Ser Glu Gly His Ile Lys Leu Thr Asp Tyr Gly Met Cys 
385                 390                 395                 400 


Lys Glu Gly Leu Arg Pro Gly Asp Thr Thr Ser Thr Phe Cys Gly Thr 
                405                 410                 415     


Pro Asn Tyr Ile Ala Pro Glu Ile Leu Arg Gly Glu Asp Tyr Gly Phe 
            420                 425                 430         


Ser Val Asp Trp Trp Ala Leu Gly Val Leu Met Phe Glu Met Met Ala 
        435                 440                 445             


Gly Arg Ser Pro Phe Asp Ile Val Gly Ser Ser Asp Asn Pro Asp Gln 
    450                 455                 460                 


Asn Thr Glu Asp Tyr Leu Phe Gln Val Ile Leu Glu Lys Gln Ile Arg 
465                 470                 475                 480 


Ile Pro Arg Ser Leu Ser Val Lys Ala Ala Ser Val Leu Lys Ser Phe 
                485                 490                 495     


Leu Asn Lys Asp Pro Lys Glu Arg Leu Gly Cys His Pro Gln Thr Gly 
            500                 505                 510         


Phe Ala Asp Ile Gln Gly His Pro Phe Phe Arg Asn Val Asp Trp Asp 
        515                 520                 525             


Met Met Glu Gln Lys Gln Val Val Pro Pro Phe Lys Pro Asn Ile Ser 
    530                 535                 540                 


Gly Glu Phe Gly Leu Asp Asn Phe Asp Ser Gln Phe Thr Asn Glu Pro 
545                 550                 555                 560 


Val Gln Leu Thr Pro Asp Asp Asp Asp Ile Val Arg Lys Ile Asp Gln 
                565                 570                 575     


Ser Glu Phe Glu Gly Phe Glu Tyr Ile Asn Pro Leu Leu Met Ser Ala 
            580                 585                 590         


Glu Glu Cys Val 
        595     


<210>  867
<211>  587
<212>  PRT
<213>  Homo sapiens

<400>  867

Met Ser His Thr Val Ala Gly Gly Gly Ser Gly Asp His Ser His Gln 
1               5                   10                  15      


Val Arg Val Lys Ala Tyr Tyr Arg Gly Asp Ile Met Ile Thr His Phe 
            20                  25                  30          


Glu Pro Ser Ile Ser Phe Glu Gly Leu Cys Asn Glu Val Arg Asp Met 
        35                  40                  45              


Cys Ser Phe Asp Asn Glu Gln Leu Phe Thr Met Lys Trp Ile Asp Glu 
    50                  55                  60                  


Glu Gly Asp Pro Cys Thr Val Ser Ser Gln Leu Glu Leu Glu Glu Ala 
65                  70                  75                  80  


Phe Arg Leu Tyr Glu Leu Asn Lys Asp Ser Glu Leu Leu Ile His Val 
                85                  90                  95      


Phe Pro Cys Val Pro Glu Arg Pro Gly Met Pro Cys Pro Gly Glu Asp 
            100                 105                 110         


Lys Ser Ile Tyr Arg Arg Gly Ala Arg Arg Trp Arg Lys Leu Tyr Cys 
        115                 120                 125             


Ala Asn Gly His Thr Phe Gln Ala Lys Arg Phe Asn Arg Arg Ala His 
    130                 135                 140                 


Cys Ala Ile Cys Thr Asp Arg Ile Trp Gly Leu Gly Arg Gln Gly Tyr 
145                 150                 155                 160 


Lys Cys Ile Asn Cys Lys Leu Leu Val His Lys Lys Cys His Lys Leu 
                165                 170                 175     


Val Thr Ile Glu Cys Gly Arg His Ser Leu Pro Gln Glu Pro Val Met 
            180                 185                 190         


Pro Met Asp Gln Ser Ser Met His Ser Asp His Ala Gln Thr Val Ile 
        195                 200                 205             


Pro Tyr Asn Pro Ser Ser His Glu Ser Leu Asp Gln Val Gly Glu Glu 
    210                 215                 220                 


Lys Glu Ala Met Asn Thr Arg Glu Ser Gly Lys Ala Ser Ser Ser Leu 
225                 230                 235                 240 


Gly Leu Gln Asp Phe Asp Leu Leu Arg Val Ile Gly Arg Gly Ser Tyr 
                245                 250                 255     


Ala Lys Val Leu Leu Val Arg Leu Lys Lys Thr Asp Arg Ile Tyr Ala 
            260                 265                 270         


Met Lys Val Val Lys Lys Glu Leu Val Asn Asp Asp Glu Asp Ile Asp 
        275                 280                 285             


Trp Val Gln Thr Glu Lys His Val Phe Glu Gln Ala Ser Asn His Pro 
    290                 295                 300                 


Phe Leu Val Gly Leu His Ser Cys Phe Gln Thr Glu Ser Arg Leu Phe 
305                 310                 315                 320 


Phe Val Ile Glu Tyr Val Asn Gly Gly Asp Leu Met Phe His Met Gln 
                325                 330                 335     


Arg Gln Arg Lys Leu Pro Glu Glu His Ala Arg Phe Tyr Ser Ala Glu 
            340                 345                 350         


Ile Ser Leu Ala Leu Asn Tyr Leu His Glu Arg Gly Ile Ile Tyr Arg 
        355                 360                 365             


Asp Leu Lys Leu Asp Asn Val Leu Leu Asp Ser Glu Gly His Ile Lys 
    370                 375                 380                 


Leu Thr Asp Tyr Gly Met Cys Lys Glu Gly Leu Arg Pro Gly Asp Thr 
385                 390                 395                 400 


Thr Ser Thr Phe Cys Gly Thr Pro Asn Tyr Ile Ala Pro Glu Ile Leu 
                405                 410                 415     


Arg Gly Glu Asp Tyr Gly Phe Ser Val Asp Trp Trp Ala Leu Gly Val 
            420                 425                 430         


Leu Met Phe Glu Met Met Ala Gly Arg Ser Pro Phe Asp Ile Val Gly 
        435                 440                 445             


Ser Ser Asp Asn Pro Asp Gln Asn Thr Glu Asp Tyr Leu Phe Gln Val 
    450                 455                 460                 


Ile Leu Glu Lys Gln Ile Arg Ile Pro Arg Ser Leu Ser Val Lys Ala 
465                 470                 475                 480 


Ala Ser Val Leu Lys Ser Phe Leu Asn Lys Asp Pro Lys Glu Arg Leu 
                485                 490                 495     


Gly Cys His Pro Gln Thr Gly Phe Ala Asp Ile Gln Gly His Pro Phe 
            500                 505                 510         


Phe Arg Asn Val Asp Trp Asp Met Met Glu Gln Lys Gln Val Val Pro 
        515                 520                 525             


Pro Phe Lys Pro Asn Ile Ser Gly Glu Phe Gly Leu Asp Asn Phe Asp 
    530                 535                 540                 


Ser Gln Phe Thr Asn Glu Pro Val Gln Leu Thr Pro Asp Asp Asp Asp 
545                 550                 555                 560 


Ile Val Arg Lys Ile Asp Gln Ser Glu Phe Glu Gly Phe Glu Tyr Ile 
                565                 570                 575     


Asn Pro Leu Leu Met Ser Ala Glu Glu Cys Val 
            580                 585         


<210>  868
<211>  1717
<212>  DNA
<213>  Homo sapiens

<400>  868
gtggcagcgg tgaccgcctc ctgggttatt ttcttttctc ccccagctgc cccagggttc       60

tggtttcccg aatcacttgg caaataacca gcaggtgggc agatgtcttt tttgcgttcc      120

tacggacgcg taggcaagtt cgatgcgccg gagtgaacag ccagggtccc atctctcagc      180

cggctcccgg gcggtgctag cagggaagag ggacgcgccg gcgaatgaaa cactactagc      240

ccggaaagcc gccctggacc ttccacccgg gcagcgagtc tggcggcccc tcgccgccgc      300

cccctccgac cagaacagac tgcgctgcga gccccgggct tccgccgcag cgcgcagcaa      360

ttggaggtgc cagaggagac cagcagcagc acttgattta gctgggctgc gggaattccg      420

acctgtacac tttccagaag cctgatctct ccaagtccgc gcccagggac tcgagccccg      480

gcttccaggt tgacccgagc gcgccccctt cgtgctctcg gccgcgttca ccgcgcgagg      540

cctccgggtc ctgttaagcc cgagcagcac aggccgctgc ctcagcatcc accccgcagc      600

ccacgtgtgg caagccgggg aaggggtgga gtgaacggcc ggagaccacg tggagaaagg      660

ggccgctttg gcccttccat ctgggtgccg ggagccccta ggccctccgg ccatggccga      720

cagcggcgat gctggcagct ccggcccctg gtggaaatcg ctcaccaaca gcagaaagaa      780

aagcaaggaa gccgcagtgg gggtgccgcc tcccgcccag cccgctcccg gggagcccac      840

gccacctgcg ccgcccagcc cggactggac cagcagctcc cgggagaacc agcaccccaa      900

tctcctcggg ggcgccggcg agccccccaa accagacaag ttatacgggg acaaatccgg      960

cagcagccgc cgcaatttga agatctcgcg ctccggccgc tttaaggaga agaggaaagt     1020

gcgcgccacg ctgctcccgg aggcgggcag gtccccggag gaggcaggct ttcctggtga     1080

cccccacgag gacaagcagt agccccaata gcctgcgcgc tccaggactg cctacccagc     1140

actaccccaa acccccagtt ccaaacccga gacttcaggc ccgccccctt acgcgttgtc     1200

tcattccacc aaattcagaa tatttacaca atgccttcat gattttattt ttctggaaat     1260

tgaagtgtca attgggttct caatatttca tgactccaag gatgcattaa atatttattt     1320

gtggtaagag aagatacctg ccgcggagga gggtggcata attatttttt tttcaaaaag     1380

ctattctggg gccctggccc cctggctcct gtcacagctc agcttgaact ctgtagcctc     1440

tcaaatgaag aaggtggctg ttatttagga ctctgtggaa agcaaatcac agtgctgttt     1500

ttaatgcctg agaaatgcac tttaggggta gacttatacc ttaagtgaag gagtggggga     1560

ggaagaagca ttcttaagta gaagcatttt aaaataaggc aggattgctt ttaatgttaa     1620

actacaaaac tgtacagcct attttagtgt ggactattaa aacccttgca ctgtaaggaa     1680

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaa                              1717


<210>  869
<211>  129
<212>  PRT
<213>  Homo sapiens

<400>  869

Met Ala Asp Ser Gly Asp Ala Gly Ser Ser Gly Pro Trp Trp Lys Ser 
1               5                   10                  15      


Leu Thr Asn Ser Arg Lys Lys Ser Lys Glu Ala Ala Val Gly Val Pro 
            20                  25                  30          


Pro Pro Ala Gln Pro Ala Pro Gly Glu Pro Thr Pro Pro Ala Pro Pro 
        35                  40                  45              


Ser Pro Asp Trp Thr Ser Ser Ser Arg Glu Asn Gln His Pro Asn Leu 
    50                  55                  60                  


Leu Gly Gly Ala Gly Glu Pro Pro Lys Pro Asp Lys Leu Tyr Gly Asp 
65                  70                  75                  80  


Lys Ser Gly Ser Ser Arg Arg Asn Leu Lys Ile Ser Arg Ser Gly Arg 
                85                  90                  95      


Phe Lys Glu Lys Arg Lys Val Arg Ala Thr Leu Leu Pro Glu Ala Gly 
            100                 105                 110         


Arg Ser Pro Glu Glu Ala Gly Phe Pro Gly Asp Pro His Glu Asp Lys 
        115                 120                 125             


Gln 
    


<210>  870
<211>  129
<212>  PRT
<213>  Homo sapiens

<400>  870

Met Ala Asp Ser Gly Asp Ala Gly Ser Ser Gly Pro Trp Trp Lys Ser 
1               5                   10                  15      


Leu Thr Asn Ser Arg Lys Lys Ser Lys Glu Ala Ala Val Gly Val Pro 
            20                  25                  30          


Pro Pro Ala Gln Pro Ala Pro Gly Glu Pro Thr Pro Pro Ala Pro Pro 
        35                  40                  45              


Ser Pro Asp Trp Thr Ser Ser Ser Arg Glu Asn Gln His Pro Asn Leu 
    50                  55                  60                  


Leu Gly Gly Ala Gly Glu Pro Pro Lys Pro Asp Lys Leu Tyr Gly Asp 
65                  70                  75                  80  


Lys Ser Gly Ser Ser Arg Arg Asn Leu Lys Ile Ser Arg Ser Gly Arg 
                85                  90                  95      


Phe Lys Glu Lys Arg Lys Val Arg Ala Thr Leu Leu Pro Glu Ala Gly 
            100                 105                 110         


Arg Ser Pro Glu Glu Ala Gly Phe Pro Gly Asp Pro His Glu Asp Lys 
        115                 120                 125             


Gln 
    


<210>  871
<211>  4443
<212>  DNA
<213>  Homo sapiens

<400>  871
tggagcgcgc aggcgcgacg tgcggctcgc agaacggcga gtagcggagc gggacccgct       60

ggaatcatca tccagggacg tgccagaaac cacaagaaaa catggggagg gttttcctca      120

cgggagaaaa agccaattcc atattaaaac gctacccaag agctaatggg ttttttgaag      180

aaataagaca gggcaacatt gagcgtgagt gcaaagaaga attctgtaca tttgaagaag      240

caagagaagc ttttgaaaat aatgaaaaaa ctaaggagtt ttggagcacc tacacaaaag      300

cgcaacaagg ggagagtaac cgaggaagtg actggtttca gttttacctt acctttccgt      360

taatctttgg cctcttcatt atcctccttg tcattttcct aatctggaga tgcttcctaa      420

gaaacaaaac tcgtagacag acagtgactg aaggccacat tcctttccct cagcacctta      480

atattatcac cccacccccc ccaccagatg aagtgtttga cagcagtgga ttgtctccag      540

gctttctggg atatgtagtt gggcgctcag attccgtctc tactcgcctg tccaattgtg      600

atcccccgcc aacctatgag gaagccactg gccaagtgaa cctgcagagg agtgaaacag      660

aacctcattt agacccaccc ccagagtatg aggacatagt caactccaac tcagccagtg      720

ccattcctat ggtgcctgtg gtcaccacca tcaaatgaag ctgcaaactt ctttttactc      780

taatcatttt taaaatacta atggaagaac tttctagcac tttaccacta cataaatgtt      840

cattgactta ttttattgga ctcttaccgc ataccacttc acacttgttt tattttcttt      900

agttttgttt cttgttatag aatcattatc catgctcatt tttgctaggg gaaatatatg      960

aagagggaaa acatactaat gggggtcttt ctgtgatgtg atgagacata catgtaagtg     1020

tatatatgtg tgtataggca tatatacgtg tgtatgcatc aacacagtat atgtaaaact     1080

gtcttaaaaa tccattaact tctacctaaa tcacctggaa ggagagcatt gctcaccaaa     1140

attgcaaaac aagggtatca agaatttgtg taatagccag tgacatgctg tagatttttg     1200

caaactggat gtacttagca tgttttctaa ttctgactgg cttttgttaa cttgataatt     1260

cttcatctac cttaaaaaga aaaaaattac acatagtcat tcttgatgtt ataaatagag     1320

aaaaagtgtg tgtgagcaat aatgcataag ctactgataa cttgcttaca gcagatagca     1380

ataaggtatt tggtggcatt cggcttgttt tgtaataggg attttttttt tggttgacca     1440

ctcccccaca cttccaaaat taaacagtgt tttcttagca tcttgaatat ctcctgcggt     1500

gtatattaac atcttgatga gacagatttc caggcaacaa aataatttct aaaatggata     1560

tatgtgtgga ttaatgacag gcagtaaata cccattactc ctttactcat agctggtaaa     1620

attattccca ctgttttatt gccttttact gtacgttcta cactctgtcc tactcccaca     1680

gaattttcaa gcccttaaga gtttagttaa aataaaattt ttgaaattat tgtcttaata     1740

tttttatata ggctgatgtc tttgcctcaa gattgttagg aggtaatttt ccattgaatt     1800

atcaactgtg atttttatag tgccctccaa gtggtagaag aagattgcaa agtccatgtt     1860

atgctaggtg cacaataaat ctagtaatag ccccacacag atctcatcat tgttgctact     1920

tccttttgta ttttcatcag gtattttttt aactgtaggg tttttacttt tttcttggag     1980

cagagagaac aggctgtaaa tgggttgcca acataagctg gctgagaaat aaaagaaaac     2040

aagacagttg ttcataaagt ttcattttgt atgcactgat ggcaaattca ttaggtcagt     2100

taagggaaat atttgtacca cttccaaact tttcagcgtt ggataaaatg attgatgagg     2160

caggcagaag gaatgtaggt ttcaggtgtg tcatttcctg ctgcttccag ctccatccct     2220

acagactcct ccccgagtcc tgccctggaa ccaaaggaag gaggaacact gaggggaatc     2280

ctgaagtagg agtcagatga cctgaactca gatctccctc tatcacatgc ttgccaccac     2340

tgtaccttga gcaagaatca tatctgaccc tcaacctcct caactctaaa atggggataa     2400

catcatttgt cctgcacttc tctaagggct ttacaaggat caaataagat ggtgtgtatg     2460

taagaaattt gtaaaatgtg aagagctatc tacactaagt tcgtaatgtt attattattg     2520

tgcttcatgg agaattttcc cctctgtttt cctaaattgt atgagagctt tcacacagtg     2580

agaaatagag caggctgccc cataaatggg taacatattc ctaatctgag tgtgtgggct     2640

gttagagaac ccctgccatg ctctggtctg ttctgaaact gtgccaactg aaagatgata     2700

gtccacacag cacaaacagg tttaagcaaa tgatagaaag ggaagtaagg cgtgtgtgct     2760

agttaatagg tttagtagct tttatggact aaaaatgatt gattgtatct tgaccctggt     2820

ctcagaaatg acatttttac ttttgccatg agtacacatc agatatcttt ggcttctatt     2880

taaagctaaa ggtagaagtg tttgatccag tgaactgtgt atgtatgtgt ggggtttttt     2940

ttctttattt ttaaatgaaa attaagacac cttttgtgtg gacatgtttt tgtctttaat     3000

gtcaggcttt agattagacc agcagttttc aaagtatggc caatggaccc ctgggttcct     3060

tgagagcctt tcagggggga ctatgagatc aaaatatttt tattataatg tgaagacatt     3120

gtcttttcac tctatctcaa aaaaagtgtt gcaaatgtaa aacattgcca tcttctcaca     3180

aatctctttt tttgtttttg aaaatatggc catttttcat aaaatgttat ttgtgttagc     3240

atgtaatggg tttactatgt ttaaataagt taatacttta aaaattttca ggttttttta     3300

gtatggtgaa tattgataga tataaacctc atgaacaaaa gtactttggc atccagattc     3360

tcaataaatg ttaagagcgt aagtgtaagg gggtccagag accaaaagtt ttagagctac     3420

aggattagac ataggagcag gatattctgt tagtgtgatt tcttgcaact ttattttaca     3480

ttttaaactg ctgatattgg atataatgct gctttttaga gacacctaaa ttgcagtatc     3540

agaatgaatg ttgatgtttg aagccaaaaa gccaaatgct taaactgatc aatgactgta     3600

gctttttaga ctgttggtca aagaacattc tacttcacag taatagctct atcagccaca     3660

gatctcatgg tggctgttgc atgataatga taggataaac aaaataccac tgtcttcaag     3720

aaacattatc ttaggtttgt ttgtttggtt tgagtttgat ttggctttta tattttttaa     3780

aatccctttt gctaccccat ctggttttat aaactgagtt tcttagcatt cgttaaaatt     3840

aaggggtttg tttggaataa tatatatttt ttatgctttt gtctttctta cctgattgat     3900

attacattca cctttgattg ttttttaaaa gtttattttt acagaatata tttagtacct     3960

ttcttaagga gtaactgaat tgaatcaacc agtttgcatt taaataaaag aacaggctca     4020

gtggtcttcc tgtagaatgg tttacatgcc tgcatgtgca gtagttgtgt ctggaatcct     4080

agaattggca ctttctgcct ccttgctcta aatgtcacaa aaaattatac ttccttaaag     4140

taaatgtaat gatttcttct tttcctattg accagtacag atagatatgt tgtgtttgct     4200

tcatttttaa tgatgacttc aagattgatg atgtgatcca ataactgtgg aggtagcttt     4260

aacttggttc tgtgtaaata gtatgtattt tattataata tttctcattt taagatgctt     4320

ggtttacatt aaattatggt atttaactat ttttatgttt atactaggta gggtctttct     4380

tatgtttctg tgtttttggt atgctaaata aagctatttt taaacccaaa aaaaaaaaaa     4440

aaa                                                                   4443


<210>  872
<211>  218
<212>  PRT
<213>  Homo sapiens

<400>  872

Met Gly Arg Val Phe Leu Thr Gly Glu Lys Ala Asn Ser Ile Leu Lys 
1               5                   10                  15      


Arg Tyr Pro Arg Ala Asn Gly Phe Phe Glu Glu Ile Arg Gln Gly Asn 
            20                  25                  30          


Ile Glu Arg Glu Cys Lys Glu Glu Phe Cys Thr Phe Glu Glu Ala Arg 
        35                  40                  45              


Glu Ala Phe Glu Asn Asn Glu Lys Thr Lys Glu Phe Trp Ser Thr Tyr 
    50                  55                  60                  


Thr Lys Ala Gln Gln Gly Glu Ser Asn Arg Gly Ser Asp Trp Phe Gln 
65                  70                  75                  80  


Phe Tyr Leu Thr Phe Pro Leu Ile Phe Gly Leu Phe Ile Ile Leu Leu 
                85                  90                  95      


Val Ile Phe Leu Ile Trp Arg Cys Phe Leu Arg Asn Lys Thr Arg Arg 
            100                 105                 110         


Gln Thr Val Thr Glu Gly His Ile Pro Phe Pro Gln His Leu Asn Ile 
        115                 120                 125             


Ile Thr Pro Pro Pro Pro Pro Asp Glu Val Phe Asp Ser Ser Gly Leu 
    130                 135                 140                 


Ser Pro Gly Phe Leu Gly Tyr Val Val Gly Arg Ser Asp Ser Val Ser 
145                 150                 155                 160 


Thr Arg Leu Ser Asn Cys Asp Pro Pro Pro Thr Tyr Glu Glu Ala Thr 
                165                 170                 175     


Gly Gln Val Asn Leu Gln Arg Ser Glu Thr Glu Pro His Leu Asp Pro 
            180                 185                 190         


Pro Pro Glu Tyr Glu Asp Ile Val Asn Ser Asn Ser Ala Ser Ala Ile 
        195                 200                 205             


Pro Met Val Pro Val Val Thr Thr Ile Lys 
    210                 215             


<210>  873
<211>  218
<212>  PRT
<213>  Homo sapiens

<400>  873

Met Gly Arg Val Phe Leu Thr Gly Glu Lys Ala Asn Ser Ile Leu Lys 
1               5                   10                  15      


Arg Tyr Pro Arg Ala Asn Gly Phe Phe Glu Glu Ile Arg Gln Gly Asn 
            20                  25                  30          


Ile Glu Arg Glu Cys Lys Glu Glu Phe Cys Thr Phe Glu Glu Ala Arg 
        35                  40                  45              


Glu Ala Phe Glu Asn Asn Glu Lys Thr Lys Glu Phe Trp Ser Thr Tyr 
    50                  55                  60                  


Thr Lys Ala Gln Gln Gly Glu Ser Asn Arg Gly Ser Asp Trp Phe Gln 
65                  70                  75                  80  


Phe Tyr Leu Thr Phe Pro Leu Ile Phe Gly Leu Phe Ile Ile Leu Leu 
                85                  90                  95      


Val Ile Phe Leu Ile Trp Arg Cys Phe Leu Arg Asn Lys Thr Arg Arg 
            100                 105                 110         


Gln Thr Val Thr Glu Gly His Ile Pro Phe Pro Gln His Leu Asn Ile 
        115                 120                 125             


Ile Thr Pro Pro Pro Pro Pro Asp Glu Val Phe Asp Ser Ser Gly Leu 
    130                 135                 140                 


Ser Pro Gly Phe Leu Gly Tyr Val Val Gly Arg Ser Asp Ser Val Ser 
145                 150                 155                 160 


Thr Arg Leu Ser Asn Cys Asp Pro Pro Pro Thr Tyr Glu Glu Ala Thr 
                165                 170                 175     


Gly Gln Val Asn Leu Gln Arg Ser Glu Thr Glu Pro His Leu Asp Pro 
            180                 185                 190         


Pro Pro Glu Tyr Glu Asp Ile Val Asn Ser Asn Ser Ala Ser Ala Ile 
        195                 200                 205             


Pro Met Val Pro Val Val Thr Thr Ile Lys 
    210                 215             


<210>  874
<211>  692
<212>  DNA
<213>  Homo sapiens

<400>  874
cctagtacac cgcaatcatg tctattatgt cctataacgg aggggccgtc atggccatga       60

aggggaagaa ctgtgtggcc atcgctgcag acaggcgctt cgggatccag gcccagttgg      120

tgaccacgga cttccagaag atctttccca tgggtgaccg gctgtacatc ggtctggccg      180

ggctcgccac tgacgtccag acagttgccc agcgcctcaa gttccggctg aacctgtatg      240

agttgaagga aggtcggcag atcaaacctt ataccctcat gagcatggtg gccaacctct      300

tgtatgagaa acggtttggc ccttactaca ctgagccagt cattgccggg ttggacccga      360

agacctttaa gcccttcatt tgctctctag acctcatcgg ctgccccatg gtgactgatg      420

actttgtggt cagtggcacc tgcgccgaac aaatgtacgg aatgtgtgag tccctctggg      480

agcccaacat ggatccggat cacctgtttg aaaccatctc ccaagccatg ctgaatgctg      540

tggaccggga tgcagtgtca ggcatgggag tcattgtcca catcatcgag aaggacaaaa      600

tcaccaccag gacactgaag gcccgaatgg actaaccctg ttcccagagc ccactttttt      660

ttcttttttt gaaataaaat agcctgtctt tc                                    692


<210>  875
<211>  205
<212>  PRT
<213>  Homo sapiens

<400>  875

Met Ser Ile Met Ser Tyr Asn Gly Gly Ala Val Met Ala Met Lys Gly 
1               5                   10                  15      


Lys Asn Cys Val Ala Ile Ala Ala Asp Arg Arg Phe Gly Ile Gln Ala 
            20                  25                  30          


Gln Met Val Thr Thr Asp Phe Gln Lys Ile Phe Pro Met Gly Asp Arg 
        35                  40                  45              


Leu Tyr Ile Gly Leu Ala Gly Leu Ala Thr Asp Val Gln Thr Val Ala 
    50                  55                  60                  


Gln Arg Leu Lys Phe Arg Leu Asn Leu Tyr Glu Leu Lys Glu Gly Arg 
65                  70                  75                  80  


Gln Ile Lys Pro Tyr Thr Leu Met Ser Met Val Ala Asn Leu Leu Tyr 
                85                  90                  95      


Glu Lys Arg Phe Gly Pro Tyr Tyr Thr Glu Pro Val Ile Ala Gly Leu 
            100                 105                 110         


Asp Pro Lys Thr Phe Lys Pro Phe Ile Cys Ser Leu Asp Leu Ile Gly 
        115                 120                 125             


Cys Pro Met Val Thr Asp Asp Phe Val Val Ser Gly Thr Cys Ala Glu 
    130                 135                 140                 


Gln Met Tyr Gly Met Cys Glu Ser Leu Trp Glu Pro Asn Met Asp Pro 
145                 150                 155                 160 


Asp His Leu Phe Glu Thr Ile Ser Gln Ala Met Leu Asn Ala Val Asp 
                165                 170                 175     


Arg Asp Ala Val Ser Gly Met Gly Val Ile Val His Ile Ile Glu Lys 
            180                 185                 190         


Asp Lys Ile Thr Thr Arg Thr Leu Lys Ala Arg Met Asp 
        195                 200                 205 


<210>  876
<211>  205
<212>  PRT
<213>  Homo sapiens

<400>  876

Met Ser Ile Met Ser Tyr Asn Gly Gly Ala Val Met Ala Met Lys Gly 
1               5                   10                  15      


Lys Asn Cys Val Ala Ile Ala Ala Asp Arg Arg Phe Gly Ile Gln Ala 
            20                  25                  30          


Gln Met Val Thr Thr Asp Phe Gln Lys Ile Phe Pro Met Gly Asp Arg 
        35                  40                  45              


Leu Tyr Ile Gly Leu Ala Gly Leu Ala Thr Asp Val Gln Thr Val Ala 
    50                  55                  60                  


Gln Arg Leu Lys Phe Arg Leu Asn Leu Tyr Glu Leu Lys Glu Gly Arg 
65                  70                  75                  80  


Gln Ile Lys Pro Tyr Thr Leu Met Ser Met Val Ala Asn Leu Leu Tyr 
                85                  90                  95      


Glu Lys Arg Phe Gly Pro Tyr Tyr Thr Glu Pro Val Ile Ala Gly Leu 
            100                 105                 110         


Asp Pro Lys Thr Phe Lys Pro Phe Ile Cys Ser Leu Asp Leu Ile Gly 
        115                 120                 125             


Cys Pro Met Val Thr Asp Asp Phe Val Val Ser Gly Thr Cys Ala Glu 
    130                 135                 140                 


Gln Met Tyr Gly Met Cys Glu Ser Leu Trp Glu Pro Asn Met Asp Pro 
145                 150                 155                 160 


Asp His Leu Phe Glu Thr Ile Ser Gln Ala Met Leu Asn Ala Val Asp 
                165                 170                 175     


Arg Asp Ala Val Ser Gly Met Gly Val Ile Val His Ile Ile Glu Lys 
            180                 185                 190         


Asp Lys Ile Thr Thr Arg Thr Leu Lys Ala Arg Met Asp 
        195                 200                 205 


<210>  877
<211>  1745
<212>  DNA
<213>  Homo sapiens

<400>  877
ggggatgccc gttcgctcgg gatcaggaac ggtgagctcc tgggaccgca atgccctgag       60

aacgcagccg ggtgctgagc ctccggagtc cggtagctga atgaaatacg cagggatcac      120

cagccggacc caaatcttgc gtccctgcca gcatcctgga gtcctaagag gcagggattg      180

gagcggacag gatctcagaa ctctggtccc gggcgcacaa cggcggagtc gctgttcctg      240

gtgctgaaac gctcagtcct ggaagaacgt ggccgcctgc ccgcctggta ccgcgccgcg      300

gccgctgcgg ggaactgtcc agtgctgaaa acggatgcgg cccggcccgc agagctcaga      360

cccaagcctg ccgcacccag cggagctcga accgagctcc tggaagcgct gacgcagagc      420

gcagggagag ccggagcggc gagctccaag cctggcatgg acctgcagag acccgattcc      480

taccagggag gagctggccc tgacttcaac gaccacgtcc tgcataagac catcctggtg      540

ggtgacagtg gtgtgggaaa gacgtctctg ctggttcagt tcgatcaggg caagttcatc      600

cccggctcct tctcggccac tgtgggcatc ggattcacga acaaggtggt gactgtggat      660

ggcgtgagag tgaagctgca gatctgggac accgctgggc aggaacggtt ccgaagcgtc      720

acccatgctt attacagaga tgctcaggcc ttgcttctgc tgtatgacat caccaacaaa      780

tcttctttcg acaacatcag ggcctggctc actgagattc atgagtatgc ccagagggac      840

gtggtgatca tgctgctagg caacaaggcg gatatgagca gcgaaagagt gatccgttcc      900

gaagacggag agaccttggc cagggagtac ggtgttccct tcctggagac cagcgccaag      960

actggcatga atgtggagtt agcctttctg gccatcgcca aggaactgaa ataccgggcc     1020

gggcatcagg cggatgagcc cagcttccag atccgagact atgtagagtc ccagaagaag     1080

cgctccagct gctgctcctt catgtgaatc ccagggggca gagaggaggc tctggaggca     1140

cacaggatgc agccttcccc cacccatgcc ctttccttta acttctcaaa cagataccag     1200

ggcctaaact gctttacctc ccctcctact gagtcaggtt aggtggtggg aggtcaccca     1260

tttccgagtt aaaccaatgc aatatgagta aaacaaagtc atgtgggtat gtctggggta     1320

gagagagggg tagcaagttc atgtgtcctc cttggtcaca tatctcccaa agctctgatc     1380

cctgccatgg gaagtggaca ggaaacatga ggtcatgacc tgcaggcatc tttactgcag     1440

ctctgccggc ctggaggggg agagggggag gaagaagtat gcgctgcaca tttctgaggc     1500

tactgcattt gctttcaagg cagaaatctt gctctgagca gtcagcggct ccagtttggg     1560

cccgataagg aagttctccg tggcctccct caggcagagc agggaggagg ctgacattgc     1620

cagtctcttc tggggcccaa ggcaggttgc aggagatcca atcccataga cagctctggg     1680

cctcttgcat ttgagttttt cagaattaaa ctgcagtatt ttggaaagca aaaaaaaaaa     1740

aaaaa                                                                 1745


<210>  878
<211>  216
<212>  PRT
<213>  Homo sapiens

<400>  878

Met Asp Leu Gln Arg Pro Asp Ser Tyr Gln Gly Gly Ala Gly Pro Asp 
1               5                   10                  15      


Phe Asn Asp His Val Leu His Lys Thr Ile Leu Val Gly Asp Ser Gly 
            20                  25                  30          


Val Gly Lys Thr Ser Leu Leu Val Gln Phe Asp Gln Gly Lys Phe Ile 
        35                  40                  45              


Pro Gly Ser Phe Ser Ala Thr Val Gly Ile Gly Phe Thr Asn Lys Val 
    50                  55                  60                  


Val Thr Val Asp Gly Val Arg Val Lys Leu Gln Ile Trp Asp Thr Ala 
65                  70                  75                  80  


Gly Gln Glu Arg Phe Arg Ser Val Thr His Ala Tyr Tyr Arg Asp Ala 
                85                  90                  95      


Gln Ala Leu Leu Leu Leu Tyr Asp Ile Thr Asn Lys Ser Ser Phe Asp 
            100                 105                 110         


Asn Ile Arg Ala Trp Leu Thr Glu Ile His Glu Tyr Ala Gln Arg Asp 
        115                 120                 125             


Val Val Ile Met Leu Leu Gly Asn Lys Ala Asp Met Ser Ser Glu Arg 
    130                 135                 140                 


Val Ile Arg Ser Glu Asp Gly Glu Thr Leu Ala Arg Glu Tyr Gly Val 
145                 150                 155                 160 


Pro Phe Leu Glu Thr Ser Ala Lys Thr Gly Met Asn Val Glu Leu Ala 
                165                 170                 175     


Phe Leu Ala Ile Ala Lys Glu Leu Lys Tyr Arg Ala Gly His Gln Ala 
            180                 185                 190         


Asp Glu Pro Ser Phe Gln Ile Arg Asp Tyr Val Glu Ser Gln Lys Lys 
        195                 200                 205             


Arg Ser Ser Cys Cys Ser Phe Met 
    210                 215     


<210>  879
<211>  216
<212>  PRT
<213>  Homo sapiens

<400>  879

Met Asp Leu Gln Arg Pro Asp Ser Tyr Gln Gly Gly Ala Gly Pro Asp 
1               5                   10                  15      


Phe Asn Asp His Val Leu His Lys Thr Ile Leu Val Gly Asp Ser Gly 
            20                  25                  30          


Val Gly Lys Thr Ser Leu Leu Val Gln Phe Asp Gln Gly Lys Phe Ile 
        35                  40                  45              


Pro Gly Ser Phe Ser Ala Thr Val Gly Ile Gly Phe Thr Asn Lys Val 
    50                  55                  60                  


Val Thr Val Asp Gly Val Arg Val Lys Leu Gln Ile Trp Asp Thr Ala 
65                  70                  75                  80  


Gly Gln Glu Arg Phe Arg Ser Val Thr His Ala Tyr Tyr Arg Asp Ala 
                85                  90                  95      


Gln Ala Leu Leu Leu Leu Tyr Asp Ile Thr Asn Lys Ser Ser Phe Asp 
            100                 105                 110         


Asn Ile Arg Ala Trp Leu Thr Glu Ile His Glu Tyr Ala Gln Arg Asp 
        115                 120                 125             


Val Val Ile Met Leu Leu Gly Asn Lys Ala Asp Met Ser Ser Glu Arg 
    130                 135                 140                 


Val Ile Arg Ser Glu Asp Gly Glu Thr Leu Ala Arg Glu Tyr Gly Val 
145                 150                 155                 160 


Pro Phe Leu Glu Thr Ser Ala Lys Thr Gly Met Asn Val Glu Leu Ala 
                165                 170                 175     


Phe Leu Ala Ile Ala Lys Glu Leu Lys Tyr Arg Ala Gly His Gln Ala 
            180                 185                 190         


Asp Glu Pro Ser Phe Gln Ile Arg Asp Tyr Val Glu Ser Gln Lys Lys 
        195                 200                 205             


Arg Ser Ser Cys Cys Ser Phe Met 
    210                 215     


<210>  880
<211>  7005
<212>  DNA
<213>  Homo sapiens

<400>  880
gcttcagtcc cgcgaccgaa gcagggcgcg cagcagcgct gagtgccccg gaacgtgcgt       60

cgcgccccca gtgtccgtcg cgtccgccgc gccccgggcg gggatggggc ggccagactg      120

agcgccgcac ccgccatcca gacccgccgg ccctagccgc agtccctcca gccgtggccc      180

cagcgcgcac gggcgatggc gaaggcgacg tccggtgccg cggggctgcg tctgctgttg      240

ctgctgctgc tgccgctgct aggcaaagtg gcattgggcc tctacttctc gagggatgct      300

tactgggaga agctgtatgt ggaccaggca gccggcacgc ccttgctgta cgtccatgcc      360

ctgcgggacg cccctgagga ggtgcccagc ttccgcctgg gccagcatct ctacggcacg      420

taccgcacac ggctgcatga gaacaactgg atctgcatcc aggaggacac cggcctcctc      480

taccttaacc ggagcctgga ccatagctcc tgggagaagc tcagtgtccg caaccgcggc      540

tttcccctgc tcaccgtcta cctcaaggtc ttcctgtcac ccacatccct tcgtgagggc      600

gagtgccagt ggccaggctg tgcccgcgta tacttctcct tcttcaacac ctcctttcca      660

gcctgcagct ccctcaagcc ccgggagctc tgcttcccag agacaaggcc ctccttccgc      720

attcgggaga accgaccccc aggcaccttc caccagttcc gcctgctgcc tgtgcagttc      780

ttgtgcccca acatcagcgt ggcctacagg ctcctggagg gtgagggtct gcccttccgc      840

tgcgccccgg acagcctgga ggtgagcacg cgctgggccc tggaccgcga gcagcgggag      900

aagtacgagc tggtggccgt gtgcaccgtg cacgccggcg cgcgcgagga ggtggtgatg      960

gtgcccttcc cggtgaccgt gtacgacgag gacgactcgg cgcccacctt ccccgcgggc     1020

gtcgacaccg ccagcgccgt ggtggagttc aagcggaagg aggacaccgt ggtggccacg     1080

ctgcgtgtct tcgatgcaga cgtggtacct gcatcagggg agctggtgag gcggtacaca     1140

agcacgctgc tccccgggga cacctgggcc cagcagacct tccgggtgga acactggccc     1200

aacgagacct cggtccaggc caacggcagc ttcgtgcggg cgaccgtaca tgactatagg     1260

ctggttctca accggaacct ctccatctcg gagaaccgca ccatgcagct ggcggtgctg     1320

gtcaatgact cagacttcca gggcccagga gcgggcgtcc tcttgctcca cttcaacgtg     1380

tcggtgctgc cggtcagcct gcacctgccc agtacctact ccctctccgt gagcaggagg     1440

gctcgccgat ttgcccagat cgggaaagtc tgtgtggaaa actgccaggc attcagtggc     1500

atcaacgtcc agtacaagct gcattcctct ggtgccaact gcagcacgct aggggtggtc     1560

acctcagccg aggacacctc ggggatcctg tttgtgaatg acaccaaggc cctgcggcgg     1620

cccaagtgtg ccgaacttca ctacatggtg gtggccaccg accagcagac ctctaggcag     1680

gcccaggccc agctgcttgt aacagtggag gggtcatatg tggccgagga ggcgggctgc     1740

cccctgtcct gtgcagtcag caagagacgg ctggagtgtg aggagtgtgg cggcctgggc     1800

tccccaacag gcaggtgtga gtggaggcaa ggagatggca aagggatcac caggaacttc     1860

tccacctgct ctcccagcac caagacctgc cccgacggcc actgcgatgt tgtggagacc     1920

caagacatca acatttgccc tcaggactgc ctccggggca gcattgttgg gggacacgag     1980

cctggggagc cccgggggat taaagctggc tatggcacct gcaactgctt ccctgaggag     2040

gagaagtgct tctgcgagcc cgaagacatc caggatccac tgtgcgacga gctgtgccgc     2100

acggtgatcg cagccgctgt cctcttctcc ttcatcgtct cggtgctgct gtctgccttc     2160

tgcatccact gctaccacaa gtttgcccac aagccaccca tctcctcagc tgagatgacc     2220

ttccggaggc ccgcccaggc cttcccggtc agctactcct cttccggtgc ccgccggccc     2280

tcgctggact ccatggagaa ccaggtctcc gtggatgcct tcaagatcct ggaggatcca     2340

aagtgggaat tccctcggaa gaacttggtt cttggaaaaa ctctaggaga aggcgaattt     2400

ggaaaagtgg tcaaggcaac ggccttccat ctgaaaggca gagcagggta caccacggtg     2460

gccgtgaaga tgctgaaaga gaacgcctcc ccgagtgagc tgcgagacct gctgtcagag     2520

ttcaacgtcc tgaagcaggt caaccaccca catgtcatca aattgtatgg ggcctgcagc     2580

caggatggcc cgctcctcct catcgtggag tacgccaaat acggctccct gcggggcttc     2640

ctccgcgaga gccgcaaagt ggggcctggc tacctgggca gtggaggcag ccgcaactcc     2700

agctccctgg accacccgga tgagcgggcc ctcaccatgg gcgacctcat ctcatttgcc     2760

tggcagatct cacaggggat gcagtatctg gccgagatga agctcgttca tcgggacttg     2820

gcagccagaa acatcctggt agctgagggg cggaagatga agatttcgga tttcggcttg     2880

tcccgagatg tttatgaaga ggattcctac gtgaagagga gccagggtcg gattccagtt     2940

aaatggatgg caattgaatc cctttttgat catatctaca ccacgcaaag tgatgtatgg     3000

tcttttggtg tcctgctgtg ggagatcgtg accctagggg gaaaccccta tcctgggatt     3060

cctcctgagc ggctcttcaa ccttctgaag accggccacc ggatggagag gccagacaac     3120

tgcagcgagg agatgtaccg cctgatgctg caatgctgga agcaggagcc ggacaaaagg     3180

ccggtgtttg cggacatcag caaagacctg gagaagatga tggttaagag gagagactac     3240

ttggaccttg cggcgtccac tccatctgac tccctgattt atgacgacgg cctctcagag     3300

gaggagacac cgctggtgga ctgtaataat gcccccctcc ctcgagccct cccttccaca     3360

tggattgaaa acaaactcta tggtagaatt tcccatgcat ttactagatt ctagcaccgc     3420

tgtccccttt gcactatcct tcctctctgt gatgcttttt aaaaatgttt ctggtctgaa     3480

caaaaccaaa gtctgctctg aaccttttta tttgtaaatg tctgactttg catccagttt     3540

acatttaggc attattgcaa ctatgttttt ctaaaaggat gtgaaaataa gtgtaattac     3600

cacattgccc agcaacttag gatggtagag gaaaaaacag atcagggcgg aactctcagg     3660

ggagaccaag aacaggttga ataaggcgct tctggggtgg gaatcaagtc atagtacttc     3720

tactttaact aagtggataa atatacaaat ctggggaggt attcagttga gaaaggagcc     3780

accagcacca ctcagcctgc actgggagca cagccaggtt cccccagacc cctcctgggc     3840

aggcaggtgc ctctcagagg ccacccggca ctggcgagca gccactggcc aagcctcagc     3900

cccagtccca gccacatgtc ctccatcagg ggtagcgagg ttgcaggagc tggctggccc     3960

tgggaggacg cacccccact gctgttttca catcctttcc cttacccacc ttcaggacgg     4020

ttgtcactta tgaagtcagt gctaaagctg gagcagttgc tttttgaaag aacatggtct     4080

gtggtgctgt ggtcttacaa tggacagtaa atatggttct tgccaaaact ccttcttttg     4140

tctttgatta aatactagaa attttttctg tttcctaact tcatcattga ttgtttgaaa     4200

tcttggagtt tcaagcattt ttttcaagct gagacggttc cttttgcatg cctcctgact     4260

cactgactcc tcactggctt tgtgtctagt gccacactcc atttgtgctg acgatgctat     4320

gaggctggcc cgtgtgcacc ctcgatttgg aaggtcctct tctccgttgt aggctcagac     4380

aacagacgag tgcctccttt acgttagaga atgttttata gaacgtttcc gctgcagtaa     4440

gccattgagt gcagcagtgt gctgttgccc tacactgcct tagaaaaaga gttaagcagt     4500

tcgacaaata tacatcagat tagagagtct caagttcata aaagtcaaaa ttggtagtgt     4560

ctgttaagtt acatttacca agagagcaca tgatatttcc cctaactata acagtgtttt     4620

tggaaacctg gaacacaaaa ccattaatat aattggcaca gaaaccacga gtttggtttg     4680

aacatcaaag ggagttttgc caaggcctta ctgtctgcac ttgaagtttt ggttcttcag     4740

tgcagaacaa atgatctgtt ttcattttta ggcatgtcag acccgaactg gcctggagag     4800

agtcctgtac cactcacgag agctgatggc actaacactg ggtttccaag atatccaaat     4860

gatagtgtat atgctaactg gatgctttca ccctcagcgg caaaattaat ggacacgttt     4920

gatagttaac atttctttgt gaaaggtaat ggactcacaa ggggaagaaa catgctgaga     4980

atggaaagtc taccggccct ttctttgtga acgtcacatt ggccgagccg tgttcagttc     5040

ccaggtggca gactcgtttt tggtagtttg ttttaacttc caaggtggtt ttacttctga     5100

tagccggtga ttttccctcc tagcagacat gccacaccgg gtaagagctc tgagtcttag     5160

tggttaagca ttcctttctc ttcagtgccc agcagcaccc agtgttggtc tgtgtccatc     5220

agtgaccacc aacattctgt gttcacatgt gtgggtccaa cacttactac ctggtgtatg     5280

aaattggacc tgaactgttg gatttttcta gttgccgcca aacaaggcaa aaaaatttaa     5340

acatgaagca cacacacaaa aaaggcagta ggaaaaatgc tggccctgat gacctgtcct     5400

tattcagaat gagagactgc ggggggggcc tgggggtagt gtcaatgccc ctccagggct     5460

ggaggggaag aggggccccg aggatgggcc tgggctcagc attcgagatc ttgagaatga     5520

ttttttttaa atcatgcaac ctttccttag gaagacattt ggttttcatc atgattaaga     5580

tgattcctag atttagcaca atggagagat tccatgccat ctttactatg tggatggtgg     5640

tatcagggaa gagggctcac aagacacatt tgtcccccgg gcccaccaca tcatcctcac     5700

gtgttcggta ctgagcagcc actacccctg atgagaacag tatgaagaaa gggggctgtt     5760

ggagtcccag aattgctgac agcagaggct ttgctgctgt gaatcccacc tgccaccagc     5820

ctgcagcaca ccccacagcc aagtagaggc gaaagcagtg gctcatccta cctgttagga     5880

gcaggtaggg cttgtactca ctttaatttg aatcttatca acttactcat aaagggacag     5940

gctagctagc tgtgttagaa gtagcaatga caatgaccaa ggactgctac acctctgatt     6000

acaattctga tgtgaaaaag atggtgtttg gctcttatag agcctgtgtg aaaggcccat     6060

ggatcagctc ttcctgtgtt tgtaatttaa tgctgctaca agatgtttct gtttcttaga     6120

ttctgaccat gactcataag cttcttgtca ttcttcattg cttgtttgtg gtcacagatg     6180

cacaacactc ctccagtctt gtgggggcag cttttgggaa gtctcagcag ctcttctggc     6240

tgtgttgtca gcactgtaac ttcgcagaaa agagtcggat taccaaaaca ctgcctgctc     6300

ttcagactta aagcactgat aggacttaaa atagtctcat tcaaatactg tattttatat     6360

aggcatttca caaaaacagc aaaattgtgg cattttgtga ggccaaggct tggatgcgtg     6420

tgtaatagag ccttgtggtg tgtgcgcaca cacccagagg gagagtttga aaaatgctta     6480

ttggacacgt aacctggctc taatttgggc tgtttttcag atacactgtg ataagttctt     6540

ttacaaatat ctatagacat ggtaaacttt tggttttcag atatgcttaa tgatagtctt     6600

actaaatgca gaaataagaa taaactttct caaattatta aaaatgccta cacagtaagt     6660

gtgaattgct gcaacaggtt tgttctcagg agggtaagaa ctccaggtct aaacagctga     6720

cccagtgatg gggaatttat ccttgaccaa tttatccttg accaataacc taattgtcta     6780

ttcctgagtt ataaaagtcc ccatccttat tagctctact ggaattttca tacacgtaaa     6840

tgcagaagtt actaagtatt aagtattact gagtattaag tagtaatctg tcagttatta     6900

aaatttgtaa aatctattta tgaaaggtca ttaaaccaga tcatgttcct ttttttgtaa     6960

tcaaggtgac taagaaaatc agttgtgtaa ataaaatcat gtatc                     7005


<210>  881
<211>  1114
<212>  PRT
<213>  Homo sapiens

<400>  881

Met Ala Lys Ala Thr Ser Gly Ala Ala Gly Leu Arg Leu Leu Leu Leu 
1               5                   10                  15      


Leu Leu Leu Pro Leu Leu Gly Lys Val Ala Leu Gly Leu Tyr Phe Ser 
            20                  25                  30          


Arg Asp Ala Tyr Trp Glu Lys Leu Tyr Val Asp Gln Ala Ala Gly Thr 
        35                  40                  45              


Pro Leu Leu Tyr Val His Ala Leu Arg Asp Ala Pro Glu Glu Val Pro 
    50                  55                  60                  


Ser Phe Arg Leu Gly Gln His Leu Tyr Gly Thr Tyr Arg Thr Arg Leu 
65                  70                  75                  80  


His Glu Asn Asn Trp Ile Cys Ile Gln Glu Asp Thr Gly Leu Leu Tyr 
                85                  90                  95      


Leu Asn Arg Ser Leu Asp His Ser Ser Trp Glu Lys Leu Ser Val Arg 
            100                 105                 110         


Asn Arg Gly Phe Pro Leu Leu Thr Val Tyr Leu Lys Val Phe Leu Ser 
        115                 120                 125             


Pro Thr Ser Leu Arg Glu Gly Glu Cys Gln Trp Pro Gly Cys Ala Arg 
    130                 135                 140                 


Val Tyr Phe Ser Phe Phe Asn Thr Ser Phe Pro Ala Cys Ser Ser Leu 
145                 150                 155                 160 


Lys Pro Arg Glu Leu Cys Phe Pro Glu Thr Arg Pro Ser Phe Arg Ile 
                165                 170                 175     


Arg Glu Asn Arg Pro Pro Gly Thr Phe His Gln Phe Arg Leu Leu Pro 
            180                 185                 190         


Val Gln Phe Leu Cys Pro Asn Ile Ser Val Ala Tyr Arg Leu Leu Glu 
        195                 200                 205             


Gly Glu Gly Leu Pro Phe Arg Cys Ala Pro Asp Ser Leu Glu Val Ser 
    210                 215                 220                 


Thr Arg Trp Ala Leu Asp Arg Glu Gln Arg Glu Lys Tyr Glu Leu Val 
225                 230                 235                 240 


Ala Val Cys Thr Val His Ala Gly Ala Arg Glu Glu Val Val Met Val 
                245                 250                 255     


Pro Phe Pro Val Thr Val Tyr Asp Glu Asp Asp Ser Ala Pro Thr Phe 
            260                 265                 270         


Pro Ala Gly Val Asp Thr Ala Ser Ala Val Val Glu Phe Lys Arg Lys 
        275                 280                 285             


Glu Asp Thr Val Val Ala Thr Leu Arg Val Phe Asp Ala Asp Val Val 
    290                 295                 300                 


Pro Ala Ser Gly Glu Leu Val Arg Arg Tyr Thr Ser Thr Leu Leu Pro 
305                 310                 315                 320 


Gly Asp Thr Trp Ala Gln Gln Thr Phe Arg Val Glu His Trp Pro Asn 
                325                 330                 335     


Glu Thr Ser Val Gln Ala Asn Gly Ser Phe Val Arg Ala Thr Val His 
            340                 345                 350         


Asp Tyr Arg Leu Val Leu Asn Arg Asn Leu Ser Ile Ser Glu Asn Arg 
        355                 360                 365             


Thr Met Gln Leu Ala Val Leu Val Asn Asp Ser Asp Phe Gln Gly Pro 
    370                 375                 380                 


Gly Ala Gly Val Leu Leu Leu His Phe Asn Val Ser Val Leu Pro Val 
385                 390                 395                 400 


Ser Leu His Leu Pro Ser Thr Tyr Ser Leu Ser Val Ser Arg Arg Ala 
                405                 410                 415     


Arg Arg Phe Ala Gln Ile Gly Lys Val Cys Val Glu Asn Cys Gln Ala 
            420                 425                 430         


Phe Ser Gly Ile Asn Val Gln Tyr Lys Leu His Ser Ser Gly Ala Asn 
        435                 440                 445             


Cys Ser Thr Leu Gly Val Val Thr Ser Ala Glu Asp Thr Ser Gly Ile 
    450                 455                 460                 


Leu Phe Val Asn Asp Thr Lys Ala Leu Arg Arg Pro Lys Cys Ala Glu 
465                 470                 475                 480 


Leu His Tyr Met Val Val Ala Thr Asp Gln Gln Thr Ser Arg Gln Ala 
                485                 490                 495     


Gln Ala Gln Leu Leu Val Thr Val Glu Gly Ser Tyr Val Ala Glu Glu 
            500                 505                 510         


Ala Gly Cys Pro Leu Ser Cys Ala Val Ser Lys Arg Arg Leu Glu Cys 
        515                 520                 525             


Glu Glu Cys Gly Gly Leu Gly Ser Pro Thr Gly Arg Cys Glu Trp Arg 
    530                 535                 540                 


Gln Gly Asp Gly Lys Gly Ile Thr Arg Asn Phe Ser Thr Cys Ser Pro 
545                 550                 555                 560 


Ser Thr Lys Thr Cys Pro Asp Gly His Cys Asp Val Val Glu Thr Gln 
                565                 570                 575     


Asp Ile Asn Ile Cys Pro Gln Asp Cys Leu Arg Gly Ser Ile Val Gly 
            580                 585                 590         


Gly His Glu Pro Gly Glu Pro Arg Gly Ile Lys Ala Gly Tyr Gly Thr 
        595                 600                 605             


Cys Asn Cys Phe Pro Glu Glu Glu Lys Cys Phe Cys Glu Pro Glu Asp 
    610                 615                 620                 


Ile Gln Asp Pro Leu Cys Asp Glu Leu Cys Arg Thr Val Ile Ala Ala 
625                 630                 635                 640 


Ala Val Leu Phe Ser Phe Ile Val Ser Val Leu Leu Ser Ala Phe Cys 
                645                 650                 655     


Ile His Cys Tyr His Lys Phe Ala His Lys Pro Pro Ile Ser Ser Ala 
            660                 665                 670         


Glu Met Thr Phe Arg Arg Pro Ala Gln Ala Phe Pro Val Ser Tyr Ser 
        675                 680                 685             


Ser Ser Gly Ala Arg Arg Pro Ser Leu Asp Ser Met Glu Asn Gln Val 
    690                 695                 700                 


Ser Val Asp Ala Phe Lys Ile Leu Glu Asp Pro Lys Trp Glu Phe Pro 
705                 710                 715                 720 


Arg Lys Asn Leu Val Leu Gly Lys Thr Leu Gly Glu Gly Glu Phe Gly 
                725                 730                 735     


Lys Val Val Lys Ala Thr Ala Phe His Leu Lys Gly Arg Ala Gly Tyr 
            740                 745                 750         


Thr Thr Val Ala Val Lys Met Leu Lys Glu Asn Ala Ser Pro Ser Glu 
        755                 760                 765             


Leu Arg Asp Leu Leu Ser Glu Phe Asn Val Leu Lys Gln Val Asn His 
    770                 775                 780                 


Pro His Val Ile Lys Leu Tyr Gly Ala Cys Ser Gln Asp Gly Pro Leu 
785                 790                 795                 800 


Leu Leu Ile Val Glu Tyr Ala Lys Tyr Gly Ser Leu Arg Gly Phe Leu 
                805                 810                 815     


Arg Glu Ser Arg Lys Val Gly Pro Gly Tyr Leu Gly Ser Gly Gly Ser 
            820                 825                 830         


Arg Asn Ser Ser Ser Leu Asp His Pro Asp Glu Arg Ala Leu Thr Met 
        835                 840                 845             


Gly Asp Leu Ile Ser Phe Ala Trp Gln Ile Ser Gln Gly Met Gln Tyr 
    850                 855                 860                 


Leu Ala Glu Met Lys Leu Val His Arg Asp Leu Ala Ala Arg Asn Ile 
865                 870                 875                 880 


Leu Val Ala Glu Gly Arg Lys Met Lys Ile Ser Asp Phe Gly Leu Ser 
                885                 890                 895     


Arg Asp Val Tyr Glu Glu Asp Ser Tyr Val Lys Arg Ser Gln Gly Arg 
            900                 905                 910         


Ile Pro Val Lys Trp Met Ala Ile Glu Ser Leu Phe Asp His Ile Tyr 
        915                 920                 925             


Thr Thr Gln Ser Asp Val Trp Ser Phe Gly Val Leu Leu Trp Glu Ile 
    930                 935                 940                 


Val Thr Leu Gly Gly Asn Pro Tyr Pro Gly Ile Pro Pro Glu Arg Leu 
945                 950                 955                 960 


Phe Asn Leu Leu Lys Thr Gly His Arg Met Glu Arg Pro Asp Asn Cys 
                965                 970                 975     


Ser Glu Glu Met Tyr Arg Leu Met Leu Gln Cys Trp Lys Gln Glu Pro 
            980                 985                 990         


Asp Lys Arg Pro Val Phe Ala Asp  Ile Ser Lys Asp Leu  Glu Lys Met 
        995                 1000                 1005             


Met Val  Lys Arg Arg Asp Tyr  Leu Asp Leu Ala Ala  Ser Thr Pro 
    1010                 1015                 1020             


Ser Asp  Ser Leu Ile Tyr Asp  Asp Gly Leu Ser Glu  Glu Glu Thr 
    1025                 1030                 1035             


Pro Leu  Val Asp Cys Asn Asn  Ala Pro Leu Pro Arg  Ala Leu Pro 
    1040                 1045                 1050             


Ser Thr  Trp Ile Glu Asn Lys  Leu Tyr Gly Met Ser  Asp Pro Asn 
    1055                 1060                 1065             


Trp Pro  Gly Glu Ser Pro Val  Pro Leu Thr Arg Ala  Asp Gly Thr 
    1070                 1075                 1080             


Asn Thr  Gly Phe Pro Arg Tyr  Pro Asn Asp Ser Val  Tyr Ala Asn 
    1085                 1090                 1095             


Trp Met  Leu Ser Pro Ser Ala  Ala Lys Leu Met Asp  Thr Phe Asp 
    1100                 1105                 1110             


Ser 
    


<210>  882
<211>  469
<212>  PRT
<213>  Homo sapiens

<400>  882

His Asn Gln Thr Ser Leu Tyr Lys Lys Ala Gly Thr His Cys Tyr His 
1               5                   10                  15      


Lys Phe Ala His Lys Pro Pro Ile Ser Ser Ala Glu Met Thr Phe Arg 
            20                  25                  30          


Arg Pro Ala Gln Ala Phe Pro Val Ser Tyr Ser Ser Ser Gly Ala Arg 
        35                  40                  45              


Arg Pro Ser Leu Asp Ser Met Glu Asn Gln Val Ser Val Asp Ala Phe 
    50                  55                  60                  


Lys Ile Leu Glu Asp Pro Lys Trp Glu Phe Pro Arg Lys Asn Leu Val 
65                  70                  75                  80  


Leu Gly Lys Thr Leu Gly Glu Gly Glu Phe Gly Lys Val Val Lys Ala 
                85                  90                  95      


Thr Ala Phe His Leu Lys Gly Arg Ala Gly Tyr Thr Thr Val Ala Val 
            100                 105                 110         


Lys Met Leu Lys Glu Asn Ala Ser Pro Ser Glu Leu Arg Asp Leu Leu 
        115                 120                 125             


Ser Glu Phe Asn Val Leu Lys Gln Val Asn His Pro His Val Ile Lys 
    130                 135                 140                 


Leu Tyr Gly Ala Cys Ser Gln Asp Gly Pro Leu Leu Leu Ile Val Glu 
145                 150                 155                 160 


Tyr Ala Lys Tyr Gly Ser Leu Arg Gly Phe Leu Arg Glu Ser Arg Lys 
                165                 170                 175     


Val Gly Pro Gly Tyr Leu Gly Ser Gly Gly Ser Arg Asn Ser Ser Ser 
            180                 185                 190         


Leu Asp His Pro Asp Glu Arg Ala Leu Thr Met Gly Asp Leu Ile Ser 
        195                 200                 205             


Phe Ala Trp Gln Ile Ser Gln Gly Met Gln Tyr Leu Ala Glu Met Lys 
    210                 215                 220                 


Leu Val His Arg Asp Leu Ala Ala Arg Asn Ile Leu Val Ala Glu Gly 
225                 230                 235                 240 


Arg Lys Met Lys Ile Ser Asp Phe Gly Leu Ser Arg Asp Val Tyr Glu 
                245                 250                 255     


Glu Asp Ser Tyr Val Lys Arg Ser Gln Gly Arg Ile Pro Val Lys Trp 
            260                 265                 270         


Met Ala Ile Glu Ser Leu Phe Asp His Ile Tyr Thr Thr Gln Ser Asp 
        275                 280                 285             


Val Trp Ser Phe Gly Val Leu Leu Trp Glu Ile Val Thr Leu Gly Gly 
    290                 295                 300                 


Asn Pro Tyr Pro Gly Ile Pro Pro Glu Arg Leu Phe Asn Leu Leu Lys 
305                 310                 315                 320 


Thr Gly His Arg Met Glu Arg Pro Asp Asn Cys Ser Glu Glu Met Tyr 
                325                 330                 335     


Arg Leu Met Leu Gln Cys Trp Lys Gln Glu Pro Asp Lys Arg Pro Val 
            340                 345                 350         


Phe Ala Asp Ile Ser Lys Asp Leu Glu Lys Met Met Val Lys Arg Arg 
        355                 360                 365             


Asp Tyr Leu Asp Leu Ala Ala Ser Thr Pro Ser Asp Ser Leu Ile Tyr 
    370                 375                 380                 


Asp Asp Gly Leu Ser Glu Glu Glu Thr Pro Leu Val Asp Cys Asn Asn 
385                 390                 395                 400 


Ala Pro Leu Pro Arg Ala Leu Pro Ser Thr Trp Ile Glu Asn Lys Leu 
                405                 410                 415     


Tyr Gly Met Ser Asp Pro Asn Trp Pro Gly Glu Ser Pro Val Pro Leu 
            420                 425                 430         


Thr Arg Ala Asp Gly Thr Asn Thr Gly Phe Pro Arg Tyr Pro Asn Asp 
        435                 440                 445             


Ser Val Tyr Ala Asn Trp Met Leu Ser Pro Ser Ala Ala Lys Leu Met 
    450                 455                 460                 


Asp Thr Phe Asp Ser 
465                 


<210>  883
<211>  2384
<212>  DNA
<213>  Homo sapiens

<400>  883
atctgccacc gcagtctggt tggagctgtt gtcttgtatg ctcagcgagg cccggagaga       60

cccgggagag agctaggccg agtccaccgc ccgagtctgc tgcccgagcc cgcgttacgc      120

acaaagccgc cgatccccgg cctggggtga gcagagcgac caccgcccgg gagcagcgcg      180

gcgagacgca cggtgcgccc tatgcccccg cgcccccacc gcccccgccg cggcagccga      240

agcgcagcga gagaacgcgc caccgcgggg cccgggtgca gctagcgacc ctctcgccac      300

ctgcgcgcag cccgaggtga gcagtgagcg gcgagcggga gggcagcgag gcgttcgcgg      360

gccccctcct gctgcccggg cccggcccgc tcatggcggc catccgcaag aagctggtgg      420

tggtgggcga cggcgcgtgt ggcaagacgt gcctgctgat cgtgttcagt aaggacgagt      480

tccccgaggt gtacgtgccc accgtcttcg agaactatgt ggccgacatt gaggtggacg      540

gcaagcaggt ggagctggcg ctgtgggaca cggcgggcca ggaggactac gaccgcctgc      600

ggccgctctc ctacccggac accgacgtca ttctcatgtg cttctcggtg gacagcccgg      660

actcgctgga gaacatcccc gagaagtggg tccccgaggt gaagcacttc tgtcccaatg      720

tgcccatcat cctggtggcc aacaaaaaag acctgcgcag cgacgagcat gtccgcacag      780

agctggcccg catgaagcag gaacccgtgc gcacggatga cggccgcgcc atggccgtgc      840

gcatccaagc ctacgactac ctcgagtgct ctgccaagac caaggaaggc gtgcgcgagg      900

tcttcgagac ggccacgcgc gccgcgctgc agaagcgcta cggctcccag aacggctgca      960

tcaactgctg caaggtgcta tgagggccgc gcccgtcgcg cctgcccctg ccggcacggc     1020

tccccctcct ggaccagtcc cccgcgagcc cggagaaggg gagacccgtg tcccacaagg     1080

accccaccgg cctgcctggc atctgtctgc tgacgcctct ggcttgcgcc aggacttggc     1140

gtgggcaccg ggcgccccca tcccagtgtc tgtgtgcgtc cagctgtgtt gcacaggcct     1200

gggctcccca ctgagtgcca agggtcccct gagcatgctt ttctgaagag ccgggcctca     1260

gagtgtgtgg ctgtgtgtct gttcgactcc cctcgcccca ttttcacccc acccccgcct     1320

ctgatccccg ggggcgagat tggcgcggga gtgtggccgc gccccatcag atgttctccc     1380

ttcaccagcg ggagcttgat atcccttgtc tgtaacatag accccgggta ctgcgggagg     1440

ggagggctgc tggggaggat ggggggatgt tatataaata tagatataat tttattttcg     1500

gagctaagat ggtgttattt aagggtggtg atgggtgagc gctctggccc aggctgggcc     1560

agactcccgc ccaagcatga acaggacttg accatctttc caacccctgg ggaagacatt     1620

tgcaactgac ttggggagga cacagcttca gcacagcctc tcctgcgggc cagcccgctg     1680

cgaaccctcc accagctacc ggagggagga gggaggatgc gctgtggggt tgtttttgcc     1740

ataagcgaac tttgtgcctg tcctagaagt gaaaattgtt cagtccaaga aactgatgtt     1800

atttgattta tttaaaggct aaaatttgtt tttttattct ttgcacaatt gtttcattgt     1860

ttgacactta atgcactcgt catttgcata cgacagtagc attctgacca cacttgtacg     1920

ctgtaacctc atctacttct gatgttttta aaaaatgact tttaacaagg agagggaaaa     1980

gaaacccact aaattttgct ttgtttcctt gaagaatgtg gcaacactgt tttgtgattt     2040

tatttgtgca ggtcatgcac acagttttga taaagggcag taacaagtat tggggcctat     2100

tttttttttt tccacaaggc attctctaaa gctatgtgaa attttctctg cacctctgta     2160

cagagaatac acctgcccct gtatatcctt ttttcccctc ccctccctcc cagtggtact     2220

tctactaaat tgttgtcttg ttttttattt tttaaataaa ctgacaaatg acaaaatggt     2280

gagcttatga tgtttacata aaagttctat aagctgtgta tacagttttt tatgtaaaat     2340

attaaaagac tatgatgatg acatttaaaa aaaaaaaaaa aaaa                      2384


<210>  884
<211>  196
<212>  PRT
<213>  Homo sapiens

<400>  884

Met Ala Ala Ile Arg Lys Lys Leu Val Val Val Gly Asp Gly Ala Cys 
1               5                   10                  15      


Gly Lys Thr Cys Leu Leu Ile Val Phe Ser Lys Asp Glu Phe Pro Glu 
            20                  25                  30          


Val Tyr Val Pro Thr Val Phe Glu Asn Tyr Val Ala Asp Ile Glu Val 
        35                  40                  45              


Asp Gly Lys Gln Val Glu Leu Ala Leu Trp Asp Thr Ala Gly Gln Glu 
    50                  55                  60                  


Asp Tyr Asp Arg Leu Arg Pro Leu Ser Tyr Pro Asp Thr Asp Val Ile 
65                  70                  75                  80  


Leu Met Cys Phe Ser Val Asp Ser Pro Asp Ser Leu Glu Asn Ile Pro 
                85                  90                  95      


Glu Lys Trp Val Pro Glu Val Lys His Phe Cys Pro Asn Val Pro Ile 
            100                 105                 110         


Ile Leu Val Ala Asn Lys Lys Asp Leu Arg Ser Asp Glu His Val Arg 
        115                 120                 125             


Thr Glu Leu Ala Arg Met Lys Gln Glu Pro Val Arg Thr Asp Asp Gly 
    130                 135                 140                 


Arg Ala Met Ala Val Arg Ile Gln Ala Tyr Asp Tyr Leu Glu Cys Ser 
145                 150                 155                 160 


Ala Lys Thr Lys Glu Gly Val Arg Glu Val Phe Glu Thr Ala Thr Arg 
                165                 170                 175     


Ala Ala Leu Gln Lys Arg Tyr Gly Ser Gln Asn Gly Cys Ile Asn Cys 
            180                 185                 190         


Cys Lys Val Leu 
        195     


<210>  885
<211>  196
<212>  PRT
<213>  Homo sapiens

<400>  885

Met Ala Ala Ile Arg Lys Lys Leu Val Val Val Gly Asp Gly Ala Cys 
1               5                   10                  15      


Gly Lys Thr Cys Leu Leu Ile Val Phe Ser Lys Asp Glu Phe Pro Glu 
            20                  25                  30          


Val Tyr Val Pro Thr Val Phe Glu Asn Tyr Val Ala Asp Ile Glu Val 
        35                  40                  45              


Asp Gly Lys Gln Val Glu Leu Ala Leu Trp Asp Thr Ala Gly Gln Glu 
    50                  55                  60                  


Asp Tyr Asp Arg Leu Arg Pro Leu Ser Tyr Pro Asp Thr Asp Val Ile 
65                  70                  75                  80  


Leu Met Cys Phe Ser Val Asp Ser Pro Asp Ser Leu Glu Asn Ile Pro 
                85                  90                  95      


Glu Lys Trp Val Pro Glu Val Lys His Phe Cys Pro Asn Val Pro Ile 
            100                 105                 110         


Ile Leu Val Ala Asn Lys Lys Asp Leu Arg Ser Asp Glu His Val Arg 
        115                 120                 125             


Thr Glu Leu Ala Arg Met Lys Gln Glu Pro Val Arg Thr Asp Asp Gly 
    130                 135                 140                 


Arg Ala Met Ala Val Arg Ile Gln Ala Tyr Asp Tyr Leu Glu Cys Ser 
145                 150                 155                 160 


Ala Lys Thr Lys Glu Gly Val Arg Glu Val Phe Glu Thr Ala Thr Arg 
                165                 170                 175     


Ala Ala Leu Gln Lys Arg Tyr Gly Ser Gln Asn Gly Cys Ile Asn Cys 
            180                 185                 190         


Cys Lys Val Leu 
        195     


<210>  886
<211>  1764
<212>  DNA
<213>  Homo sapiens

<400>  886
gagcccgatt taacggaaac tgtgggcggt gagaagttcc ttatgacaca ctaatcccaa       60

cctgctgacc ggaccacgcc tccagcggag ggaacctcta gagctccagg acattcaggt      120

accaggtagc cccaaggagg agctgccgac ctggcaggga acaaccaaga ctggggttaa      180

atctcacagc ctgcaagtgg aagagaagaa cttgaaccca ggtccaactt ttgcgccaca      240

gcaggctgcc tcttggtcct gacaggaagt cacaacttgg ccctgacttc ctatcctagg      300

gaaggggccg gctggagagg ccaggacaga gaaagcagat cccttctttt tccaaggact      360

ctgtgtcttc cataggcaac atgtcagaag gggtgggcac gttccgcatg gtacctgaag      420

aggaacagga gctccgtgcc caactggagc agctcacaac caaggaccat ggacctgtct      480

ttggcccgtg cagccagctg ccccgccaca ccttgcagaa ggccaaggat gagctgaacg      540

agagagagga gacccgggag gaggcagtgc gagagctgca ggagatggtg caggcgcagg      600

cggcctcggg ggaggagctg gcggtggccg tggcggagag ggtgcaagag aaggacagcg      660

gcttcttcct gcgcttcatc cgcgcacgga agttcaacgt gggccgtgcc tatgagctgc      720

tcagaggcta tgtgaatttc cggctgcagt accctgagct ctttgacagc ctgtccccag      780

aggctgtccg ctgcaccatt gaagctggct accctggtgt cctctctagt cgggacaagt      840

atggccgagt ggtcatgctc ttcaacattg agaactggca aagtcaagaa atcacctttg      900

atgagatctt gcaggcatat tgcttcatcc tggagaagct gctggagaat gaggaaactc      960

aaatcaatgg cttctgcatc attgagaact tcaagggctt taccatgcag caggctgcta     1020

gtctccggac ttcagatctc aggaagatgg tggacatgct ccaggattcc ttcccagccc     1080

ggttcaaagc catccacttc atccaccagc catggtactt caccacgacc tacaatgtgg     1140

tcaagccctt cttgaagagc aagctgcttg agagggtctt tgtccacggg gatgaccttt     1200

ctggtttcta ccaggagatc gatgagaaca tcctgccctc tgacttcggg ggcacgctgc     1260

ccaagtatga tggcaaggcc gttgctgagc agctctttgg cccccaggcc caagctgaga     1320

acacagcctt ctgaaaacat ctcctgccag ctgaactgta gttagaatct ctgggcctct     1380

cctcaactgt cctggaccca aggctaggaa agggctgctt gagatgactg tggtcccccc     1440

ttagactccc taagcccgag tgagctcagg tgtcaccctg ttctcaagtt gggggatggg     1500

taataaagga gggggaattc ccttgaacaa gaagaactgg ggatagttat atttccacct     1560

gcccttgaag ctttaagaca gtgatttttg tgtaaggttg tatttcaaag actcgaattc     1620

attttctcag tcatttcctt tgtaacagag ttttacgact tagagtctgt gaaaacaggc     1680

aaggagcccg ggttaaaata tccccctatt cgcccccaaa atgcaataaa agaagataaa     1740

agagagagga taaaaaaaaa aaaa                                            1764


<210>  887
<211>  317
<212>  PRT
<213>  Homo sapiens

<400>  887

Met Ser Glu Gly Val Gly Thr Phe Arg Met Val Pro Glu Glu Glu Gln 
1               5                   10                  15      


Glu Leu Arg Ala Gln Leu Glu Gln Leu Thr Thr Lys Asp His Gly Pro 
            20                  25                  30          


Val Phe Gly Pro Cys Ser Gln Leu Pro Arg His Thr Leu Gln Lys Ala 
        35                  40                  45              


Lys Asp Glu Leu Asn Glu Arg Glu Glu Thr Arg Glu Glu Ala Val Arg 
    50                  55                  60                  


Glu Leu Gln Glu Met Val Gln Ala Gln Ala Ala Ser Gly Glu Glu Leu 
65                  70                  75                  80  


Ala Val Ala Val Ala Glu Arg Val Gln Glu Lys Asp Ser Gly Phe Phe 
                85                  90                  95      


Leu Arg Phe Ile Arg Ala Arg Lys Phe Asn Val Gly Arg Ala Tyr Glu 
            100                 105                 110         


Leu Leu Arg Gly Tyr Val Asn Phe Arg Leu Gln Tyr Pro Glu Leu Phe 
        115                 120                 125             


Asp Ser Leu Ser Pro Glu Ala Val Arg Cys Thr Ile Glu Ala Gly Tyr 
    130                 135                 140                 


Pro Gly Val Leu Ser Ser Arg Asp Lys Tyr Gly Arg Val Val Met Leu 
145                 150                 155                 160 


Phe Asn Ile Glu Asn Trp Gln Ser Gln Glu Ile Thr Phe Asp Glu Ile 
                165                 170                 175     


Leu Gln Ala Tyr Cys Phe Ile Leu Glu Lys Leu Leu Glu Asn Glu Glu 
            180                 185                 190         


Thr Gln Ile Asn Gly Phe Cys Ile Ile Glu Asn Phe Lys Gly Phe Thr 
        195                 200                 205             


Met Gln Gln Ala Ala Ser Leu Arg Thr Ser Asp Leu Arg Lys Met Val 
    210                 215                 220                 


Asp Met Leu Gln Asp Ser Phe Pro Ala Arg Phe Lys Ala Ile His Phe 
225                 230                 235                 240 


Ile His Gln Pro Trp Tyr Phe Thr Thr Thr Tyr Asn Val Val Lys Pro 
                245                 250                 255     


Phe Leu Lys Ser Lys Leu Leu Glu Arg Val Phe Val His Gly Asp Asp 
            260                 265                 270         


Leu Ser Gly Phe Tyr Gln Glu Ile Asp Glu Asn Ile Leu Pro Ser Asp 
        275                 280                 285             


Phe Gly Gly Thr Leu Pro Lys Tyr Asp Gly Lys Ala Val Ala Glu Gln 
    290                 295                 300                 


Leu Phe Gly Pro Gln Ala Gln Ala Glu Asn Thr Ala Phe 
305                 310                 315         


<210>  888
<211>  317
<212>  PRT
<213>  Homo sapiens

<400>  888

Met Ser Glu Gly Val Gly Thr Phe Arg Met Val Pro Glu Glu Glu Gln 
1               5                   10                  15      


Glu Leu Arg Ala Gln Leu Glu Gln Leu Thr Thr Lys Asp His Gly Pro 
            20                  25                  30          


Val Phe Gly Pro Cys Ser Gln Leu Pro Arg His Thr Leu Gln Lys Ala 
        35                  40                  45              


Lys Asp Glu Leu Asn Glu Arg Glu Glu Thr Arg Glu Glu Ala Val Arg 
    50                  55                  60                  


Glu Leu Gln Glu Met Val Gln Ala Gln Ala Ala Ser Gly Glu Glu Leu 
65                  70                  75                  80  


Ala Val Ala Val Ala Glu Arg Val Gln Glu Lys Asp Ser Gly Phe Phe 
                85                  90                  95      


Leu Arg Phe Ile Arg Ala Arg Lys Phe Asn Val Gly Arg Ala Tyr Glu 
            100                 105                 110         


Leu Leu Arg Gly Tyr Val Asn Phe Arg Leu Gln Tyr Pro Glu Leu Phe 
        115                 120                 125             


Asp Ser Leu Ser Pro Glu Ala Val Arg Cys Thr Ile Glu Ala Gly Tyr 
    130                 135                 140                 


Pro Gly Val Leu Ser Ser Arg Asp Lys Tyr Gly Arg Val Val Met Leu 
145                 150                 155                 160 


Phe Asn Ile Glu Asn Trp Gln Ser Gln Glu Ile Thr Phe Asp Glu Ile 
                165                 170                 175     


Leu Gln Ala Tyr Cys Phe Ile Leu Glu Lys Leu Leu Glu Asn Glu Glu 
            180                 185                 190         


Thr Gln Ile Asn Gly Phe Cys Ile Ile Glu Asn Phe Lys Gly Phe Thr 
        195                 200                 205             


Met Gln Gln Ala Ala Ser Leu Arg Thr Ser Asp Leu Arg Lys Met Val 
    210                 215                 220                 


Asp Met Leu Gln Asp Ser Phe Pro Ala Arg Phe Lys Ala Ile His Phe 
225                 230                 235                 240 


Ile His Gln Pro Trp Tyr Phe Thr Thr Thr Tyr Asn Val Val Lys Pro 
                245                 250                 255     


Phe Leu Lys Ser Lys Leu Leu Glu Arg Val Phe Val His Gly Asp Asp 
            260                 265                 270         


Leu Ser Gly Phe Tyr Gln Glu Ile Asp Glu Asn Ile Leu Pro Ser Asp 
        275                 280                 285             


Phe Gly Gly Thr Leu Pro Lys Tyr Asp Gly Lys Ala Val Ala Glu Gln 
    290                 295                 300                 


Leu Phe Gly Pro Gln Ala Gln Ala Glu Asn Thr Ala Phe 
305                 310                 315         


<210>  889
<211>  3463
<212>  DNA
<213>  Homo sapiens

<400>  889
tgaataaatt attcggcatt tagcttatca ttctgaattt cactttttgc tttttggtgc       60

tctgaaactt gcagagagag gtggagtgct aaggggaggg taggggttgt gatactttgc      120

acacacatcc ctgtcattgt tctgcctaaa gagacagggc tgggttcaag gccacatgtg      180

ctcctgtcat cctccacatt tctgctccaa gtgcaatccg gagtgtcagc tctccatctg      240

tctctgcctg gcaggcgcac gcgcccagca ccctgcctcc ggcgatgccg ccccagcccc      300

tctgatggcc ctcctctctg ctgccactca ttccagaaca ggaggcatga gcccggaacg      360

cgcttgcttt taggagacag ccactttctg tgtggtacgc tggattcaag gatgcctgat      420

cgtactgaga agcactccac aatgccagac tcacctgtgg atgtgaagac gcaatctagg      480

ctgactcctc caacaatgcc acctccccca actactcaag gagctccaag aaccagttca      540

tttacaccga caacgttaac taatggcacg agccattctc ctacagcctt gaatggcgcc      600

ccctcaccac ccaatggctt cagcaatggg ccttcctctt cttcctcctc ctctctggct      660

aatcaacagc tgcccccagc ctgtggtgcc aggcaactca gcaagctgaa aaggttcctt      720

actaccctgc agcagtttgg caatgacatt tcacccgaga taggagaaag agttcgcacc      780

ctcgttctgg gactagtgaa ctccactttg acaattgaag aatttcattc caaactgcaa      840

gaagctacta acttcccact gagacctttt gtcatcccat ttttgaaggc caacttgccc      900

ctgctgcagc gtgagctcct ccactgcgca agactggcca aacagaaccc tgcccagtac      960

ctcgcccagc atgaacagct gcttctggat gccagcacca cctcacctgt tgactcctca     1020

gagctgcttc tcgatgtgaa cgaaaacggg aagaggcgaa ctccagacag aaccaaagaa     1080

aatggctttg acagagagcc tttgcactca gaacatccaa gcaagcgacc atgcactatt     1140

agcccaggcc agcggtacag tccaaataac ggcttatcct accagcccaa tggcctgcct     1200

caccctaccc cacctccacc tcagcattac cgtttggatg atatggccat tgcccaccac     1260

tacagggact cctatcgaca ccccagccac agggacctca gggacagaaa cagacctatg     1320

gggttgcatg gcacacgtca agaagaaatg attgatcaca gactaacaga cagagaatgg     1380

gcagaagagt ggaaacatct tgaccatctg ttaaactgca taatggacat ggtagaaaaa     1440

acaaggcgat ctctcaccgt actaaggcgg tgtcaagaag cagaccggga agaattgaat     1500

tactggatcc ggcggtacag tgacgccgag gacttaaaaa aaggtggcgg cagtagcagc     1560

agccactcta ggcagcagag tcccgtcaac ccagacccag ttgcactaga cgcgcatcgg     1620

gaattccttc acaggcctgc gtctggatac gtgccagagg agatctggaa gaaagctgag     1680

gaggccgtca atgaggtgaa gcgccaggcg atgacggagc tgcagaaggc cgtgtctgag     1740

gcggagcgga aagcccacga catgatcaca acagagaggg ccaagatgga gcgcacggtc     1800

gccgaggcca aacggcaggc ggcggaggac gcactggcag ttatcaatca gcaggaggat     1860

tcaagcgaga gttgctggaa ttgtggccgt aaagcgagtg aaacctgcag tggctgtaac     1920

acagcccgat actgtggctc attttgccag cacaaagact gggagaagca ccatcacatc     1980

tgtggacaga ccctgcaggc ccagcagcag ggagacacac ctgcagtcag ctcctctgtc     2040

acgcccaaca gcggggctgg gagcccgatg gacacaccac cagcagccac tccgaggtca     2100

accaccccgg gaaccccttc caccatagag acaacccctc gctagacgtg aactcagaac     2160

tgtcggagga aagacaacac aaccaacgcg aaaccaattc ctcatcctca gatgctcaaa     2220

gttgtttttt ttgtttgttt gtttattaga tgaattatcc tatttcagta cttcagcaag     2280

agagaaccta actgtatctt gaggtggtag taaaacacag agggccagta acgggtcgta     2340

atgacttatt gtggataaca aagatatctt ttctttagag aactgaaaag agagcagaga     2400

atataacatg aaatgataga tttgacctcc tccctgttat tttcaagtag ctgggatttt     2460

aaactagatg acctcattaa ccgatgcttt accaaacagc aaaccaagag attgctaatt     2520

gctgttgaaa gcaaaaatgc taatattaaa agtcacaatg ttctttatat acaataatgg     2580

aaaaaaaaaa aagaggaaaa ccctcaaggg catgagcatt ggatacagca gtagacattt     2640

taacaagaag atgaatggcg tccgtgggtt gctaactgaa ctttgaagac ccgctacaaa     2700

acgcgcagat gtgcagcaga ttggaaggag acacagatgt tcggtttttt tcctgtttct     2760

gaaaagaaat aataatatcc aggtcaacag aatgaaaaat gaaagatgat ttgcaatggg     2820

atgtatgaat acagcagcaa gaaaaaaaaa tgccataata caaaaggctc catatatata     2880

tatatatata tatatataca cacacacaca cgcacatata cacacacaca cacacacaca     2940

cacacacaca cacacacaca cacacacaca cacaagtaag agactcagcc tgcagttaat     3000

tagcattctg gcagttttga catcagccag ctgccctaaa taacccttca acgtttcttc     3060

acttttgcaa ggttccacag agtaagacat tgggtctatt ccagctcatt cattttatat     3120

tgaaaaaaat aattttaaaa atggtggctt cagctccagc ccctttccaa aatttttcaa     3180

ccccaccctg tttggatttt taattaaaaa ctagtagttc tcttggtgtt aaaacacttc     3240

tgtcctgtga ggtttcccaa tggtgttttt cttgtaaatg tgttggacaa atgtgaagat     3300

gcattgtagt ttaaccatat gcccacattt agtctcttta ttcctagttg gtgagaaacc     3360

tgtatctttc tatgctgctt ttatatctgt atgtattagt gatatttctc tagtagttaa     3420

aaaaaaaaaa aggaaaaaaa gactcttttt ggttgtcctc aag                       3463


<210>  890
<211>  604
<212>  PRT
<213>  Homo sapiens

<400>  890

Met Ile Ser Val Lys Arg Asn Thr Trp Arg Ala Leu Ser Leu Val Ile 
1               5                   10                  15      


Gly Asp Cys Arg Lys Lys Gly Asn Phe Glu Tyr Cys Gln Asp Arg Thr 
            20                  25                  30          


Glu Lys His Ser Thr Met Pro Asp Ser Pro Val Asp Val Lys Thr Gln 
        35                  40                  45              


Ser Arg Leu Thr Pro Pro Thr Met Pro Pro Pro Pro Thr Thr Gln Gly 
    50                  55                  60                  


Ala Pro Arg Thr Ser Ser Phe Thr Pro Thr Thr Leu Thr Asn Gly Thr 
65                  70                  75                  80  


Ser His Ser Pro Thr Ala Leu Asn Gly Ala Pro Ser Pro Pro Asn Gly 
                85                  90                  95      


Phe Ser Asn Gly Pro Ser Ser Ser Ser Ser Ser Ser Leu Ala Asn Gln 
            100                 105                 110         


Gln Leu Pro Pro Ala Cys Gly Ala Arg Gln Leu Ser Lys Leu Lys Arg 
        115                 120                 125             


Phe Leu Thr Thr Leu Gln Gln Phe Gly Asn Asp Ile Ser Pro Glu Ile 
    130                 135                 140                 


Gly Glu Arg Val Arg Thr Leu Val Leu Gly Leu Val Asn Ser Thr Leu 
145                 150                 155                 160 


Thr Ile Glu Glu Phe His Ser Lys Leu Gln Glu Ala Thr Asn Phe Pro 
                165                 170                 175     


Leu Arg Pro Phe Val Ile Pro Phe Leu Lys Ala Asn Leu Pro Leu Leu 
            180                 185                 190         


Gln Arg Glu Leu Leu His Cys Ala Arg Leu Ala Lys Gln Asn Pro Ala 
        195                 200                 205             


Gln Tyr Leu Ala Gln His Glu Gln Leu Leu Leu Asp Ala Ser Thr Thr 
    210                 215                 220                 


Ser Pro Val Asp Ser Ser Glu Leu Leu Leu Asp Val Asn Glu Asn Gly 
225                 230                 235                 240 


Lys Arg Arg Thr Pro Asp Arg Thr Lys Glu Asn Gly Phe Asp Arg Glu 
                245                 250                 255     


Pro Leu His Ser Glu His Pro Ser Lys Arg Pro Cys Thr Ile Ser Pro 
            260                 265                 270         


Gly Gln Arg Tyr Ser Pro Asn Asn Gly Leu Ser Tyr Gln Pro Asn Gly 
        275                 280                 285             


Leu Pro His Pro Thr Pro Pro Pro Pro Gln His Tyr Arg Leu Asp Asp 
    290                 295                 300                 


Met Ala Ile Ala His His Tyr Arg Asp Ser Tyr Arg His Pro Ser His 
305                 310                 315                 320 


Arg Asp Leu Arg Asp Arg Asn Arg Pro Met Gly Leu His Gly Thr Arg 
                325                 330                 335     


Gln Glu Glu Met Ile Asp His Arg Leu Thr Asp Arg Glu Trp Ala Glu 
            340                 345                 350         


Glu Trp Lys His Leu Asp His Leu Leu Asn Cys Ile Met Asp Met Val 
        355                 360                 365             


Glu Lys Thr Arg Arg Ser Leu Thr Val Leu Arg Arg Cys Gln Glu Ala 
    370                 375                 380                 


Asp Arg Glu Glu Leu Asn Tyr Trp Ile Arg Arg Tyr Ser Asp Ala Glu 
385                 390                 395                 400 


Asp Leu Lys Lys Gly Gly Gly Ser Ser Ser Ser His Ser Arg Gln Gln 
                405                 410                 415     


Ser Pro Val Asn Pro Asp Pro Val Ala Leu Asp Ala His Arg Glu Phe 
            420                 425                 430         


Leu His Arg Pro Ala Ser Gly Tyr Val Pro Glu Glu Ile Trp Lys Lys 
        435                 440                 445             


Ala Glu Glu Ala Val Asn Glu Val Lys Arg Gln Ala Met Thr Glu Leu 
    450                 455                 460                 


Gln Lys Ala Val Ser Glu Ala Glu Arg Lys Ala His Asp Met Ile Thr 
465                 470                 475                 480 


Thr Glu Arg Ala Lys Met Glu Arg Thr Val Ala Glu Ala Lys Arg Gln 
                485                 490                 495     


Ala Ala Glu Asp Ala Leu Ala Val Ile Asn Gln Gln Glu Asp Ser Ser 
            500                 505                 510         


Glu Ser Cys Trp Asn Cys Gly Arg Lys Ala Ser Glu Thr Cys Ser Gly 
        515                 520                 525             


Cys Asn Thr Ala Arg Tyr Cys Gly Ser Phe Cys Gln His Lys Asp Trp 
    530                 535                 540                 


Glu Lys His His His Ile Cys Gly Gln Thr Leu Gln Ala Gln Gln Gln 
545                 550                 555                 560 


Gly Asp Thr Pro Ala Val Ser Ser Ser Val Thr Pro Asn Ser Gly Ala 
                565                 570                 575     


Gly Ser Pro Met Asp Thr Pro Pro Ala Ala Thr Pro Arg Ser Thr Thr 
            580                 585                 590         


Pro Gly Thr Pro Ser Thr Ile Glu Thr Thr Pro Arg 
        595                 600                 


<210>  891
<211>  577
<212>  PRT
<213>  Homo sapiens

<400>  891

Met Pro Asp Arg Thr Glu Lys His Ser Thr Met Pro Asp Ser Pro Val 
1               5                   10                  15      


Asp Val Lys Thr Gln Ser Arg Leu Thr Pro Pro Thr Met Pro Pro Pro 
            20                  25                  30          


Pro Thr Thr Gln Gly Ala Pro Arg Thr Ser Ser Phe Thr Pro Thr Thr 
        35                  40                  45              


Leu Thr Asn Gly Thr Ser His Ser Pro Thr Ala Leu Asn Gly Ala Pro 
    50                  55                  60                  


Ser Pro Pro Asn Gly Phe Ser Asn Gly Pro Ser Ser Ser Ser Ser Ser 
65                  70                  75                  80  


Ser Leu Ala Asn Gln Gln Leu Pro Pro Ala Cys Gly Ala Arg Gln Leu 
                85                  90                  95      


Ser Lys Leu Lys Arg Phe Leu Thr Thr Leu Gln Gln Phe Gly Asn Asp 
            100                 105                 110         


Ile Ser Pro Glu Ile Gly Glu Arg Val Arg Thr Leu Val Leu Gly Leu 
        115                 120                 125             


Val Asn Ser Thr Leu Thr Ile Glu Glu Phe His Ser Lys Leu Gln Glu 
    130                 135                 140                 


Ala Thr Asn Phe Pro Leu Arg Pro Phe Val Ile Pro Phe Leu Lys Ala 
145                 150                 155                 160 


Asn Leu Pro Leu Leu Gln Arg Glu Leu Leu His Cys Ala Arg Leu Ala 
                165                 170                 175     


Lys Gln Asn Pro Ala Gln Tyr Leu Ala Gln His Glu Gln Leu Leu Leu 
            180                 185                 190         


Asp Ala Ser Thr Thr Ser Pro Val Asp Ser Ser Glu Leu Leu Leu Asp 
        195                 200                 205             


Val Asn Glu Asn Gly Lys Arg Arg Thr Pro Asp Arg Thr Lys Glu Asn 
    210                 215                 220                 


Gly Phe Asp Arg Glu Pro Leu His Ser Glu His Pro Ser Lys Arg Pro 
225                 230                 235                 240 


Cys Thr Ile Ser Pro Gly Gln Arg Tyr Ser Pro Asn Asn Gly Leu Ser 
                245                 250                 255     


Tyr Gln Pro Asn Gly Leu Pro His Pro Thr Pro Pro Pro Pro Gln His 
            260                 265                 270         


Tyr Arg Leu Asp Asp Met Ala Ile Ala His His Tyr Arg Asp Ser Tyr 
        275                 280                 285             


Arg His Pro Ser His Arg Asp Leu Arg Asp Arg Asn Arg Pro Met Gly 
    290                 295                 300                 


Leu His Gly Thr Arg Gln Glu Glu Met Ile Asp His Arg Leu Thr Asp 
305                 310                 315                 320 


Arg Glu Trp Ala Glu Glu Trp Lys His Leu Asp His Leu Leu Asn Cys 
                325                 330                 335     


Ile Met Asp Met Val Glu Lys Thr Arg Arg Ser Leu Thr Val Leu Arg 
            340                 345                 350         


Arg Cys Gln Glu Ala Asp Arg Glu Glu Leu Asn Tyr Trp Ile Arg Arg 
        355                 360                 365             


Tyr Ser Asp Ala Glu Asp Leu Lys Lys Gly Gly Gly Ser Ser Ser Ser 
    370                 375                 380                 


His Ser Arg Gln Gln Ser Pro Val Asn Pro Asp Pro Val Ala Leu Asp 
385                 390                 395                 400 


Ala His Arg Glu Phe Leu His Arg Pro Ala Ser Gly Tyr Val Pro Glu 
                405                 410                 415     


Glu Ile Trp Lys Lys Ala Glu Glu Ala Val Asn Glu Val Lys Arg Gln 
            420                 425                 430         


Ala Met Thr Glu Leu Gln Lys Ala Val Ser Glu Ala Glu Arg Lys Ala 
        435                 440                 445             


His Asp Met Ile Thr Thr Glu Arg Ala Lys Met Glu Arg Thr Val Ala 
    450                 455                 460                 


Glu Ala Lys Arg Gln Ala Ala Glu Asp Ala Leu Ala Val Ile Asn Gln 
465                 470                 475                 480 


Gln Glu Asp Ser Ser Glu Ser Cys Trp Asn Cys Gly Arg Lys Ala Ser 
                485                 490                 495     


Glu Thr Cys Ser Gly Cys Asn Thr Ala Arg Tyr Cys Gly Ser Phe Cys 
            500                 505                 510         


Gln His Lys Asp Trp Glu Lys His His His Ile Cys Gly Gln Thr Leu 
        515                 520                 525             


Gln Ala Gln Gln Gln Gly Asp Thr Pro Ala Val Ser Ser Ser Val Thr 
    530                 535                 540                 


Pro Asn Ser Gly Ala Gly Ser Pro Met Asp Thr Pro Pro Ala Ala Thr 
545                 550                 555                 560 


Pro Arg Ser Thr Thr Pro Gly Thr Pro Ser Thr Ile Glu Thr Thr Pro 
                565                 570                 575     


Arg 
    


<210>  892
<211>  1566
<212>  DNA
<213>  Homo sapiens

<400>  892
ccttgtcctg cccagatctt gtcccttcta gtactggcct tccccattcc tgggggcccc       60

cgcccctccg acccccgccg accggcgctg gactacaact cccggcgtgc cgcgcgcgtc      120

cggccggctg caccggggct ttgcgcgtgg cggccgccga gctccgcgcg gggcaaacct      180

cccggcgcgg ccatgcgggg agttgctgaa gtaaaggaac cctgcagcct tcccatgcta      240

tctgttgaca tggaaaacaa ggaaaatggc tctgtcggtg taaaaaattc catggaaaat      300

gggagaccac ctgatcctgc agactgggcc gtgatggatg tcgtcaatta tttccgaacc      360

gtgggatttg aggagcaagc tagtgctttt caggaacagg aaattgatgg aaaatccctg      420

ctattgatga caagaaatga tgtgttgaca ggacttcagt taaaattggg gcctgctctg      480

aaaatctacg aatatcatgt aaaacctctg cagacaaagc atttaaagaa caactcttca      540

tagtacagtc aaattggggt cttcgacctc aaaaaaatac ataatgacat aatttagttt      600

catgtaatga aactttgtaa acagaataca tacatgtgta tatgtaaaga atttcaatca      660

aatgaaacgt tatcctattg gatagactag gcaattcatc agctcacctg aaatcagcca      720

ggaggagcaa ggacaagatg cgcacagggt ggttttcctc atggattttg tcaaatagat      780

gatctttgac acgattagac actcctcccc acaaaggctt tgaaatcata aggattttcc      840

tcatctcttt atagctttcc caaaatcttt taaaaaagaa tttaattaaa tgacagtctt      900

ttggttacag acttaggatg agtaaaaaca agaaaatttg gggaggggga gaaagaagaa      960

agggattgct gtctcccttg aattcctctg ttccttagag cttgtgttac ttggacggaa     1020

ttgccaacac ccttttttat agagggttct ccacttgacc ttattaaggt tttattggga     1080

tatgctgcag tgtttgaaat gaacatgcat catggcccct tcaggagcag aatcatagct     1140

ctgaaaagag aagctccgtt gtgtactgag gatatccatc catattcagc tagctttcaa     1200

atggggtaat gatattttct gcatagattt tcttttaaat tggttctttg tttctgaaga     1260

aagaattttt tttaacttca tggttttatt tataataatt tgtttctgaa gaaatttgcc     1320

gagagttaca ggtcaaaaag ccttgttact agtacagaat atttttatat atattccttc     1380

atgatggtgt aatttttttt aattgtccta tgctttgttc ggttcctggg ttaagtactt     1440

gtttttaaga gcttggaaaa agtgggcttg ctacatctct gttcaaagag acatttgttc     1500

aatctctgtg tgtcaacgcc ttgttgaatt ggtgctttgt ggttgcaata aagcattgct     1560

tcagtt                                                                1566


<210>  893
<211>  122
<212>  PRT
<213>  Homo sapiens

<400>  893

Met Ala Asn Ser Leu Leu Glu Gly Val Phe Ala Glu Val Lys Glu Pro 
1               5                   10                  15      


Cys Ser Leu Pro Met Leu Ser Val Asp Met Glu Asn Lys Glu Asn Gly 
            20                  25                  30          


Ser Val Gly Val Lys Asn Ser Met Glu Asn Gly Arg Pro Pro Asp Pro 
        35                  40                  45              


Ala Asp Trp Ala Val Met Asp Val Val Asn Tyr Phe Arg Thr Val Gly 
    50                  55                  60                  


Phe Glu Glu Gln Ala Ser Ala Phe Gln Glu Gln Glu Ile Asp Gly Lys 
65                  70                  75                  80  


Ser Leu Leu Leu Met Thr Arg Asn Asp Val Leu Thr Gly Leu Gln Leu 
                85                  90                  95      


Lys Leu Gly Pro Ala Leu Lys Ile Tyr Glu Tyr His Val Lys Pro Leu 
            100                 105                 110         


Gln Thr Lys His Leu Lys Asn Asn Ser Ser 
        115                 120         


<210>  894
<211>  116
<212>  PRT
<213>  Homo sapiens

<400>  894

Met Arg Gly Val Ala Glu Val Lys Glu Pro Cys Ser Leu Pro Met Leu 
1               5                   10                  15      


Ser Val Asp Met Glu Asn Lys Glu Asn Gly Ser Val Gly Val Lys Asn 
            20                  25                  30          


Ser Met Glu Asn Gly Arg Pro Pro Asp Pro Ala Asp Trp Ala Val Met 
        35                  40                  45              


Asp Val Val Asn Tyr Phe Arg Thr Val Gly Phe Glu Glu Gln Ala Ser 
    50                  55                  60                  


Ala Phe Gln Glu Gln Glu Ile Asp Gly Lys Ser Leu Leu Leu Met Thr 
65                  70                  75                  80  


Arg Asn Asp Val Leu Thr Gly Leu Gln Leu Lys Leu Gly Pro Ala Leu 
                85                  90                  95      


Lys Ile Tyr Glu Tyr His Val Lys Pro Leu Gln Thr Lys His Leu Lys 
            100                 105                 110         


Asn Asn Ser Ser 
        115     


<210>  895
<211>  1717
<212>  DNA
<213>  Homo sapiens

<400>  895
ggccggggaa aaacccggat gagctgggca gcagtgttgg cagtcgcggc tgcgagattt       60

gggcactttt gggggtgccg gtggcccggg ccgatggcgc aaggttgggc aggcttctct      120

gaggaggaac tgaggagact aaagcagact aaagatccat ttgaaccaca gcgacgtctc      180

cccgcgaaga aaagtcgaca acaacttcag cgagaaaaag cccttgtaga gcaaagccaa      240

aaacttgggc ttcaagatgg atcaacctca ttacttccag agcagctgct ttcagcacca      300

aaacagagag ttaacgttca aaaaccacct ttttcttccc ctactcttcc gagtcatttc      360

actctcacct cccccgttgg tgatggacaa ccacagggca ttgaaagtca gccaaaggaa      420

ctgggacttg agaattccca tgatggtcac aacaatgttg agattctacc tccaaagcca      480

gattgcaaat tggagaaaaa gaaagtggaa ttgcaagaaa aatctcgttg ggaagtcctc      540

caacaagaac aacggctaat ggaagagaaa aataaacgta aaaaagctct tttggctaaa      600

gctattgcag aaagatctaa aagaactcag gcagagacca tgaaactaaa gcggatccag      660

aaggagttgc aggctttaga tgacatggtg tcagctgaca ttggaattct caggaaccgg      720

attgatcagg ccagcttaga ctattcatac gctcggtgag ttggggaaat tgaatctgaa      780

caaggagtat gatttaatta atgtttattg ccagctgttc caggggcttt tatgtatatc      840

atcattgaag cctcaaaaca accccattca gtgctgtatt tattcttctt ttgtgctaat      900

tcaagtgtct cctcttcagt gaagtcttcc ttaactctgc cctactagtt aaccttgttc      960

gtgtgccatt agagcagttc ttgcattatt tatttacgtt ttagtctttg ctgcgaaacc     1020

ctcagctatt taatgtttgg aagtgttttt gctcatcttt cagcatctag caaagtaaat     1080

atctgagtgg tttcgccaaa actgttactc tgacaccaag tctgtgttct ttccattaaa     1140

atttttgata tctgatatag tcctatagga ttgaagtcta gtcctcactt tagctttcat     1200

cagagtaaga ggatctagtt tagtttttaa aagcttatga atattttaag catatcctct     1260

gtcttggaaa tttgaaatat tttctctttt tttttccttt caattatact ctgtatgaaa     1320

tggtttaata tatgtttcct tggtttcaac cattggcatt ttttaaaaga gaaaaaatac     1380

catggagtat ttttaaaatg aactaacaca tgtaatgaat tacatggact ttgcagacag     1440

ataaaagggc aaaaaaatat gtccaatttc agggttttca gccctttcaa cattgcttta     1500

atcatcctgg tttgtctttt ttcacaaggg aatgctgtgt taatgactca gttttctatc     1560

ttactctgtt acactagaaa tgaatcagaa tgcctcatta ggccagggta aaccacaaca     1620

tcagaatgtt tatataacaa tttattaaag cggaaatgct tgattgtggt ttttaataaa     1680

ctgttgagtg tttaagaaaa aaaaaaaaaa aaaaaaa                              1717


<210>  896
<211>  394
<212>  PRT
<213>  Homo sapiens

<400>  896

Met Ser Trp Ala Ala Val Leu Ala Val Ala Ala Ala Arg Phe Gly His 
1               5                   10                  15      


Phe Trp Gly Cys Arg Trp Pro Gly Pro Met Ala Gln Gly Trp Ala Gly 
            20                  25                  30          


Phe Ser Glu Glu Glu Leu Arg Arg Leu Lys Gln Thr Lys Asp Pro Phe 
        35                  40                  45              


Glu Pro Gln Arg Arg Leu Pro Ala Lys Lys Ser Arg Gln Gln Leu Gln 
    50                  55                  60                  


Arg Glu Lys Ala Leu Val Glu Gln Ser Gln Lys Leu Gly Leu Gln Asp 
65                  70                  75                  80  


Gly Ser Thr Ser Leu Leu Pro Glu Gln Leu Leu Ser Ala Pro Lys Gln 
                85                  90                  95      


Arg Val Asn Val Gln Lys Pro Pro Phe Ser Ser Pro Thr Leu Pro Ser 
            100                 105                 110         


His Phe Thr Leu Thr Ser Pro Val Gly Asp Gly Gln Pro Gln Gly Ile 
        115                 120                 125             


Glu Ser Gln Pro Lys Glu Leu Gly Leu Glu Asn Ser His Asp Gly His 
    130                 135                 140                 


Asn Asn Val Glu Ile Leu Pro Pro Lys Pro Asp Cys Lys Leu Glu Lys 
145                 150                 155                 160 


Lys Lys Val Glu Leu Gln Glu Lys Ser Arg Trp Glu Val Leu Gln Gln 
                165                 170                 175     


Glu Gln Arg Leu Met Glu Glu Lys Asn Lys Arg Lys Lys Ala Leu Leu 
            180                 185                 190         


Ala Lys Ala Ile Ala Glu Arg Ser Lys Arg Thr Gln Ala Glu Thr Met 
        195                 200                 205             


Lys Leu Lys Arg Ile Gln Lys Glu Leu Gln Ala Leu Asp Asp Met Val 
    210                 215                 220                 


Ser Ala Asp Ile Gly Ile Leu Arg Asn Arg Ile Asp Gln Ala Ser Leu 
225                 230                 235                 240 


Asp Tyr Ser Tyr Ala Arg Lys Arg Phe Asp Arg Ala Glu Ala Glu Tyr 
                245                 250                 255     


Ile Ala Ala Lys Leu Asp Ile Gln Arg Lys Thr Glu Ile Lys Glu Gln 
            260                 265                 270         


Leu Thr Glu His Leu Cys Thr Ile Ile Gln Gln Asn Glu Leu Arg Lys 
        275                 280                 285             


Ala Lys Lys Leu Glu Glu Leu Met Gln Gln Leu Asp Val Glu Ala Asp 
    290                 295                 300                 


Glu Glu Thr Leu Glu Leu Glu Val Glu Val Glu Arg Leu Leu His Glu 
305                 310                 315                 320 


Gln Glu Val Glu Ser Arg Arg Pro Val Val Arg Leu Glu Arg Pro Phe 
                325                 330                 335     


Gln Pro Ala Glu Glu Ser Val Thr Leu Glu Phe Ala Lys Glu Asn Arg 
            340                 345                 350         


Lys Cys Gln Glu Gln Ala Val Ser Pro Lys Val Asp Asp Gln Cys Gly 
        355                 360                 365             


Asn Ser Ser Ser Ile Pro Phe Leu Ser Pro Asn Cys Pro Asn Gln Glu 
    370                 375                 380                 


Gly Asn Asp Ile Ser Ala Ala Leu Ala Thr 
385                 390                 


<210>  897
<211>  246
<212>  PRT
<213>  Homo sapiens

<400>  897

Met Ser Trp Ala Ala Val Leu Ala Val Ala Ala Ala Arg Phe Gly His 
1               5                   10                  15      


Phe Trp Gly Cys Arg Trp Pro Gly Pro Met Ala Gln Gly Trp Ala Gly 
            20                  25                  30          


Phe Ser Glu Glu Glu Leu Arg Arg Leu Lys Gln Thr Lys Asp Pro Phe 
        35                  40                  45              


Glu Pro Gln Arg Arg Leu Pro Ala Lys Lys Ser Arg Gln Gln Leu Gln 
    50                  55                  60                  


Arg Glu Lys Ala Leu Val Glu Gln Ser Gln Lys Leu Gly Leu Gln Asp 
65                  70                  75                  80  


Gly Ser Thr Ser Leu Leu Pro Glu Gln Leu Leu Ser Ala Pro Lys Gln 
                85                  90                  95      


Arg Val Asn Val Gln Lys Pro Pro Phe Ser Ser Pro Thr Leu Pro Ser 
            100                 105                 110         


His Phe Thr Leu Thr Ser Pro Val Gly Asp Gly Gln Pro Gln Gly Ile 
        115                 120                 125             


Glu Ser Gln Pro Lys Glu Leu Gly Leu Glu Asn Ser His Asp Gly His 
    130                 135                 140                 


Asn Asn Val Glu Ile Leu Pro Pro Lys Pro Asp Cys Lys Leu Glu Lys 
145                 150                 155                 160 


Lys Lys Val Glu Leu Gln Glu Lys Ser Arg Trp Glu Val Leu Gln Gln 
                165                 170                 175     


Glu Gln Arg Leu Met Glu Glu Lys Asn Lys Arg Lys Lys Ala Leu Leu 
            180                 185                 190         


Ala Lys Ala Ile Ala Glu Arg Ser Lys Arg Thr Gln Ala Glu Thr Met 
        195                 200                 205             


Lys Leu Lys Arg Ile Gln Lys Glu Leu Gln Ala Leu Asp Asp Met Val 
    210                 215                 220                 


Ser Ala Asp Ile Gly Ile Leu Arg Asn Arg Ile Asp Gln Ala Ser Leu 
225                 230                 235                 240 


Asp Tyr Ser Tyr Ala Arg 
                245     


<210>  898
<211>  1075
<212>  DNA
<213>  Homo sapiens

<400>  898
gttttcttcg aagatttggg gctccgcgat acagttagga tggctgtagt acctctgctg       60

ttgttggggg gtttgtggag cgctgtggga gcgtccagcc tgggtgtcgt tacttgcggc      120

tccgtggtga agctactcaa tacgcgccac aacgtccgac tgcactcaca cgacgtgcgc      180

tatgggtcag gtagtgggca gcagtcagtg acaggtgtaa cctctgtgga tgacagcaac      240

agttactgga ggatacgggg gaagagtgcc acagtgtgtg agaggggaac ccccatcaag      300

tgtggccagc ccatccggct gacacatgtc aacactggcc gaaacctcca tagtcaccac      360

ttcacttcac ctctttctgg aaaccaggaa gtgagtgctt ttggtgagga aggtgaaggt      420

gattatctgg atgactggac agtgctctgt aatggaccct actgggtgag agatggtgag      480

gtgcggttca aacactcttc cactgaggta ctgctgtctg tcacaggaga acaatatggt      540

cgacctatca gtgggcaaaa agaggtgcat ggcatggccc agccaagtca gaacaactac      600

tggaaagcca tggaaggcat cttcatgaag cccagtgagt tgttgaaggc agaagcccac      660

catgcagagc tgtgaatcta gaggctctga gccactgtta acgcacaatg ttcacagaca      720

tctgttgctg cctcaccttg ggatccctgc cacaagttcc ttgggcagtg gccatgtcac      780

cattgagatg aagatataca acagaaaata gtggctgtgt ttggaagctt cagccctgca      840

catttgaact agtcactctc ccagacttgc gtgggtcagt tctttctgag tagaggactt      900

gctggtaaag gggcagatgc tttttattag tactgataaa acaaactgag ggaaacatcc      960

ctcttagctg ggaaactttt actcttcagg agcttggcat catggactgt taatgtatgt     1020

gattttcccc ctattttctc tctccaaaat gataaaaaca ataattttat tatga          1075


<210>  899
<211>  211
<212>  PRT
<213>  Homo sapiens

<400>  899

Met Ala Val Val Pro Leu Leu Leu Leu Gly Gly Leu Trp Ser Ala Val 
1               5                   10                  15      


Gly Ala Ser Ser Leu Gly Val Val Thr Cys Gly Ser Val Val Lys Leu 
            20                  25                  30          


Leu Asn Thr Arg His Asn Val Arg Leu His Ser His Asp Val Arg Tyr 
        35                  40                  45              


Gly Ser Gly Ser Gly Gln Gln Ser Val Thr Gly Val Thr Ser Val Asp 
    50                  55                  60                  


Asp Ser Asn Ser Tyr Trp Arg Ile Arg Gly Lys Ser Ala Thr Val Cys 
65                  70                  75                  80  


Glu Arg Gly Thr Pro Ile Lys Cys Gly Gln Pro Ile Arg Leu Thr His 
                85                  90                  95      


Val Asn Thr Gly Arg Asn Leu His Ser His His Phe Thr Ser Pro Leu 
            100                 105                 110         


Ser Gly Asn Gln Glu Val Ser Ala Phe Gly Glu Glu Gly Glu Gly Asp 
        115                 120                 125             


Tyr Leu Asp Asp Trp Thr Val Leu Cys Asn Gly Pro Tyr Trp Val Arg 
    130                 135                 140                 


Asp Gly Glu Val Arg Phe Lys His Ser Ser Thr Glu Val Leu Leu Ser 
145                 150                 155                 160 


Val Thr Gly Glu Gln Tyr Gly Arg Pro Ile Ser Gly Gln Lys Glu Val 
                165                 170                 175     


His Gly Met Ala Gln Pro Ser Gln Asn Asn Tyr Trp Lys Ala Met Glu 
            180                 185                 190         


Gly Ile Phe Met Lys Pro Ser Glu Leu Leu Lys Ala Glu Ala His His 
        195                 200                 205             


Ala Glu Leu 
    210     


<210>  900
<211>  211
<212>  PRT
<213>  Homo sapiens

<400>  900

Met Ala Val Val Pro Leu Leu Leu Leu Gly Gly Leu Trp Ser Ala Val 
1               5                   10                  15      


Gly Ala Ser Ser Leu Gly Val Val Thr Cys Gly Ser Val Val Lys Leu 
            20                  25                  30          


Leu Asn Thr Arg His Asn Val Arg Leu His Ser His Asp Val Arg Tyr 
        35                  40                  45              


Gly Ser Gly Ser Gly Gln Gln Ser Val Thr Gly Val Thr Ser Val Asp 
    50                  55                  60                  


Asp Ser Asn Ser Tyr Trp Arg Ile Arg Gly Lys Ser Ala Thr Val Cys 
65                  70                  75                  80  


Glu Arg Gly Thr Pro Ile Lys Cys Gly Gln Pro Ile Arg Leu Thr His 
                85                  90                  95      


Val Asn Thr Gly Arg Asn Leu His Ser His His Phe Thr Ser Pro Leu 
            100                 105                 110         


Ser Gly Asn Gln Glu Val Ser Ala Phe Gly Glu Glu Gly Glu Gly Asp 
        115                 120                 125             


Tyr Leu Asp Asp Trp Thr Val Leu Cys Asn Gly Pro Tyr Trp Val Arg 
    130                 135                 140                 


Asp Gly Glu Val Arg Phe Lys His Ser Ser Thr Glu Val Leu Leu Ser 
145                 150                 155                 160 


Val Thr Gly Glu Gln Tyr Gly Arg Pro Ile Ser Gly Gln Lys Glu Val 
                165                 170                 175     


His Gly Met Ala Gln Pro Ser Gln Asn Asn Tyr Trp Lys Ala Met Glu 
            180                 185                 190         


Gly Ile Phe Met Lys Pro Ser Glu Leu Leu Lys Ala Glu Ala His His 
        195                 200                 205             


Ala Glu Leu 
    210     


<210>  901
<211>  2110
<212>  DNA
<213>  Homo sapiens

<400>  901
caaagagaaa ggaagcaggc ccgttggaag tggttgtgac aaccccagca atgtggagaa       60

gcctggggct tgccctggct ctctgtctcc tcccatcggg aggaacagag agccaggacc      120

aaagctcctt atgtaagcaa cccccagcct ggagcataag agatcaagat ccaatgctaa      180

actccaatgg ttcagtgact gtggttgctc ttcttcaagc cagctgatac ctgtgcatac      240

tgcaggcatc taaattagaa gacctgcgag taaaactgaa gaaagaagga tattctaata      300

tttcttatat tgttgttaat catcaaggaa tctcttctcg attaaaatac acacatctta      360

agaataaggt ttcagagcat attcctgttt atcaacaaga agaaaaccaa acagatgtct      420

ggactctttt aaatggaagc aaagatgact tcctcatata tgatagatgt ggccgtcttg      480

tatatcatct tggtttgcct ttttccttcc taactttccc atatgtagaa gaagccatta      540

agattgctta ctgtgaaaag aaatgtggaa actgctctct cacgactctc aaagatgaag      600

acttttgtaa acgtgtatct ttggctactg tggataaaac agttgaaact ccatcgcctc      660

attaccatca tgagcatcat cacaatcatg gacatcagca ccttggcagc agtgagcttt      720

cagagaatca gcaaccagga gcaccaaatg ctcctactca tcctgctcct ccaggccttc      780

atcaccacca taagcacaag ggtcagcata ggcagggtca cccagagaac cgagatatgc      840

cagcaagtga agatttacaa gatttacaaa agaagctctg tcgaaagaga tgtataaatc      900

aattactctg taaattgccc acagattcag agttggctcc taggagctga tgctgccatt      960

gtcgacatct gatatttgaa aaaacagggt ctgcaatcac ctgacagtgt aaagaaaacc     1020

tcccatcttt atgtagctga cagggacttc gggcagagga gaacataact gaatcttgtc     1080

agtgacgttt gcctccagct gcctgacaaa taagtcagca gcttataccc acagaagcca     1140

gtgccagttg acgctgaaag aatcaggcaa aaaagtgaga atgaccttca aactaaatat     1200

ttaaaatagg acatactccc caatttagtc tagacacaat ttcatttcca gcatttttat     1260

aaactaccaa attagtgaac caaaaataga aattagattt gtgcaaacat ggagaaatct     1320

actgaattgg cttccagatt ttaaatttta tgtcatagaa atattgactc aaaccatatt     1380

ttttatgatg gagcaactga aaggtgattg cagcttttgg ttaatatgtc ttttttttct     1440

ttttccagtg ttctatttgc tttaatgaga atagaaacgt aaactatgac ctaggggttt     1500

ctgttggata attagcagtt tagaatggag gaagaacaac aaagacatgc tttccatttt     1560

tttctttact tatctctcaa aacaatatta ctttgtcttt tcaatcttct acttttaact     1620

aataaaataa gtggattttg tattttaaga tccagaaata cttaacacgt gaatattttg     1680

ctaaaaaagc atatataact attttaaata tccatttatc ttttgtatat ctaagactca     1740

tcctgatttt tactatcaca catgaataaa gcctttgtat ctttctttct ctaatgttgt     1800

atcatactct tctaaaactt gagtggctgt cttaaaagat ataaggggaa agataatatt     1860

gtctgtctct atattgctta gtaagtattt ccatagtcaa tgatggttta ataggtaaac     1920

caaaccctat aaacctgacc tcctttatgg ttaatactat taagcaagaa tgcagtacag     1980

aattggatac agtacggatt tgtccaaata aattcaataa aaaccttaaa aaaaaaaaaa     2040

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa     2100

aaaaaaaaaa                                                            2110


<210>  902
<211>  381
<212>  PRT
<213>  Homo sapiens

<400>  902

Met Trp Arg Ser Leu Gly Leu Ala Leu Ala Leu Cys Leu Leu Pro Ser 
1               5                   10                  15      


Gly Gly Thr Glu Ser Gln Asp Gln Ser Ser Leu Cys Lys Gln Pro Pro 
            20                  25                  30          


Ala Trp Ser Ile Arg Asp Gln Asp Pro Met Leu Asn Ser Asn Gly Ser 
        35                  40                  45              


Val Thr Val Val Ala Leu Leu Gln Ala Ser Cys Tyr Leu Cys Ile Leu 
    50                  55                  60                  


Gln Ala Ser Lys Leu Glu Asp Leu Arg Val Lys Leu Lys Lys Glu Gly 
65                  70                  75                  80  


Tyr Ser Asn Ile Ser Tyr Ile Val Val Asn His Gln Gly Ile Ser Ser 
                85                  90                  95      


Arg Leu Lys Tyr Thr His Leu Lys Asn Lys Val Ser Glu His Ile Pro 
            100                 105                 110         


Val Tyr Gln Gln Glu Glu Asn Gln Thr Asp Val Trp Thr Leu Leu Asn 
        115                 120                 125             


Gly Ser Lys Asp Asp Phe Leu Ile Tyr Asp Arg Cys Gly Arg Leu Val 
    130                 135                 140                 


Tyr His Leu Gly Leu Pro Phe Ser Phe Leu Thr Phe Pro Tyr Val Glu 
145                 150                 155                 160 


Glu Ala Ile Lys Ile Ala Tyr Cys Glu Lys Lys Cys Gly Asn Cys Ser 
                165                 170                 175     


Leu Thr Thr Leu Lys Asp Glu Asp Phe Cys Lys Arg Val Ser Leu Ala 
            180                 185                 190         


Thr Val Asp Lys Thr Val Glu Thr Pro Ser Pro His Tyr His His Glu 
        195                 200                 205             


His His His Asn His Gly His Gln His Leu Gly Ser Ser Glu Leu Ser 
    210                 215                 220                 


Glu Asn Gln Gln Pro Gly Ala Pro Asn Ala Pro Thr His Pro Ala Pro 
225                 230                 235                 240 


Pro Gly Leu His His His His Lys His Lys Gly Gln His Arg Gln Gly 
                245                 250                 255     


His Pro Glu Asn Arg Asp Met Pro Ala Ser Glu Asp Leu Gln Asp Leu 
            260                 265                 270         


Gln Lys Lys Leu Cys Arg Lys Arg Cys Ile Asn Gln Leu Leu Cys Lys 
        275                 280                 285             


Leu Pro Thr Asp Ser Glu Leu Ala Pro Arg Ser Cys Cys Cys His Cys 
    290                 295                 300                 


Arg His Leu Ile Phe Glu Lys Thr Gly Ser Ala Ile Thr Cys Gln Cys 
305                 310                 315                 320 


Lys Glu Asn Leu Pro Ser Leu Cys Ser Cys Gln Gly Leu Arg Ala Glu 
                325                 330                 335     


Glu Asn Ile Thr Glu Ser Cys Gln Cys Arg Leu Pro Pro Ala Ala Cys 
            340                 345                 350         


Gln Ile Ser Gln Gln Leu Ile Pro Thr Glu Ala Ser Ala Ser Cys Arg 
        355                 360                 365             


Cys Lys Asn Gln Ala Lys Lys Cys Glu Cys Pro Ser Asn 
    370                 375                 380     


<210>  903
<211>  58
<212>  PRT
<213>  Homo sapiens

<400>  903

Met Trp Arg Ser Leu Gly Leu Ala Leu Ala Leu Cys Leu Leu Pro Ser 
1               5                   10                  15      


Gly Gly Thr Glu Ser Gln Asp Gln Ser Ser Leu Cys Lys Gln Pro Pro 
            20                  25                  30          


Ala Trp Ser Ile Arg Asp Gln Asp Pro Met Leu Asn Ser Asn Gly Ser 
        35                  40                  45              


Val Thr Val Val Ala Leu Leu Gln Ala Ser 
    50                  55              


<210>  904
<211>  1523
<212>  DNA
<213>  Homo sapiens

<400>  904
ggcacgaggg attctccggg atattaccgg agacggagtg ttttattatt agcctttctt       60

aggtggacat ttccatttga attacaagtc ctttaggctg ggcgtggtgc atggctgtaa      120

tctcagcacc ttgggaggct gaggcaggaa gatcacttga ggccaggcgt tggagagcag      180

cctgggcaag gtggcaagaa ccttgtctct acaaaaaaaa aagcgtctgc catcatggat      240

gttctcgcag aagcaaatgg cacctttgcc ttaaaccttt tgaaaacgct gggtaaagac      300

aactcgaaga atgtgttttt ctcacccatg agcatgtcct gtgccctggc catggtctac      360

atgggggcaa agggaaacac cgctgcacag atggcccaga tactttcttt caataaaagt      420

ggcggtggtg gagacatcca ccagggcttc cagtctcttc tcaccgaagt gaacaagact      480

ggcacgcagt acttgcttag ggtggccaac aggctctttg gggaaaagtc ttgtgatttc      540

ctctcatctt ttagagattc ctgccaaaaa ttctaccaag cagagatgga ggagcttgac      600

tttatcagcg ccgtagagaa gtccagaaaa cacataaaca cctgggtagc tgaaaagaca      660

gaaggtaaaa ttgcggagtt gctctctccg ggctcagtgg atccattgac aaggctggtt      720

ctggtgaatg ctgtctattt cagaggaaac tgggatgaac agtttgacaa ggagaacacc      780

gaggagagac tgtttaaagt cagcaagaat gaggagaaac ctgtgcaaat gatgtttaag      840

caatctactt ttaagaagac ctatatagga gaaatattta cccaaatctt ggtgcttcca      900

tatgttggca aggaactgaa tatgatcatc atgcttccgg acgagaccac tgacttgaga      960

acggtggaga aagaactcac ttacgagaag ttcgtagaat ggacgaggct ggacatgatg     1020

gatgaagagg aggtggaagt gtccctcccg cggtttaaac tagaggaaag ctacgacatg     1080

gagagtgtcc tgcgcaacct gggcatgact gatgccttcg agctgggcaa ggcagacttc     1140

tctggaatgt cccagacaga cctgtctctg tccaaggtcg tgcacaagtc ttttgtggag     1200

gtcaatgagg aaggcacgga ggctgcagcc gccacagctg ccatcatgat gatgcggtgt     1260

gccagattcg tcccccgctt ctgcgccgac caccccttcc ttttcttcat ccagcacagc     1320

aagaccaacg ggattctctt ctgcggccgc ttttcctctc cgtgaggaca gggcagtctt     1380

ggtgtgcagc ccctctcctc tctgtcccct gacactccac agtgtgcctg caacccaagt     1440

ggccttatcc gtgcagtggt ggcagttcag aaataaaggg cccatttgtg ggatgccgca     1500

ttcaaaaaaa aaaaaaaaaa aaa                                             1523


<210>  905
<211>  376
<212>  PRT
<213>  Homo sapiens

<400>  905

Met Asp Val Leu Ala Glu Ala Asn Gly Thr Phe Ala Leu Asn Leu Leu 
1               5                   10                  15      


Lys Thr Leu Gly Lys Asp Asn Ser Lys Asn Val Phe Phe Ser Pro Met 
            20                  25                  30          


Ser Met Ser Cys Ala Leu Ala Met Val Tyr Met Gly Ala Lys Gly Asn 
        35                  40                  45              


Thr Ala Ala Gln Met Ala Gln Ile Leu Ser Phe Asn Lys Ser Gly Gly 
    50                  55                  60                  


Gly Gly Asp Ile His Gln Gly Phe Gln Ser Leu Leu Thr Glu Val Asn 
65                  70                  75                  80  


Lys Thr Gly Thr Gln Tyr Leu Leu Arg Met Ala Asn Arg Leu Phe Gly 
                85                  90                  95      


Glu Lys Ser Cys Asp Phe Leu Ser Ser Phe Arg Asp Ser Cys Gln Lys 
            100                 105                 110         


Phe Tyr Gln Ala Glu Met Glu Glu Leu Asp Phe Ile Ser Ala Val Glu 
        115                 120                 125             


Lys Ser Arg Lys His Ile Asn Thr Trp Val Ala Glu Lys Thr Glu Gly 
    130                 135                 140                 


Lys Ile Ala Glu Leu Leu Ser Pro Gly Ser Val Asp Pro Leu Thr Arg 
145                 150                 155                 160 


Leu Val Leu Val Asn Ala Val Tyr Phe Arg Gly Asn Trp Asp Glu Gln 
                165                 170                 175     


Phe Asp Lys Glu Asn Thr Glu Glu Arg Leu Phe Lys Val Ser Lys Asn 
            180                 185                 190         


Glu Glu Lys Pro Val Gln Met Met Phe Lys Gln Ser Thr Phe Lys Lys 
        195                 200                 205             


Thr Tyr Ile Gly Glu Ile Phe Thr Gln Ile Leu Val Leu Pro Tyr Val 
    210                 215                 220                 


Gly Lys Glu Leu Asn Met Ile Ile Met Leu Pro Asp Glu Thr Thr Asp 
225                 230                 235                 240 


Leu Arg Thr Val Glu Lys Glu Leu Thr Tyr Glu Lys Phe Val Glu Trp 
                245                 250                 255     


Thr Arg Leu Asp Met Met Asp Glu Glu Glu Val Glu Val Ser Leu Pro 
            260                 265                 270         


Arg Phe Lys Leu Glu Glu Ser Tyr Asp Met Glu Ser Val Leu Arg Asn 
        275                 280                 285             


Leu Gly Met Thr Asp Ala Phe Glu Leu Gly Lys Ala Asp Phe Ser Gly 
    290                 295                 300                 


Met Ser Gln Thr Asp Leu Ser Leu Ser Lys Val Val His Lys Ser Phe 
305                 310                 315                 320 


Val Glu Val Asn Glu Glu Gly Thr Glu Ala Ala Ala Ala Thr Ala Ala 
                325                 330                 335     


Ile Met Met Met Arg Cys Ala Arg Phe Val Pro Arg Phe Cys Ala Asp 
            340                 345                 350         


His Pro Phe Leu Phe Phe Ile Gln His Ser Lys Thr Asn Gly Ile Leu 
        355                 360                 365             


Phe Cys Gly Arg Phe Ser Ser Pro 
    370                 375     


<210>  906
<211>  376
<212>  PRT
<213>  Homo sapiens

<400>  906

Met Asp Val Leu Ala Glu Ala Asn Gly Thr Phe Ala Leu Asn Leu Leu 
1               5                   10                  15      


Lys Thr Leu Gly Lys Asp Asn Ser Lys Asn Val Phe Phe Ser Pro Met 
            20                  25                  30          


Ser Met Ser Cys Ala Leu Ala Met Val Tyr Met Gly Ala Lys Gly Asn 
        35                  40                  45              


Thr Ala Ala Gln Met Ala Gln Ile Leu Ser Phe Asn Lys Ser Gly Gly 
    50                  55                  60                  


Gly Gly Asp Ile His Gln Gly Phe Gln Ser Leu Leu Thr Glu Val Asn 
65                  70                  75                  80  


Lys Thr Gly Thr Gln Tyr Leu Leu Arg Val Ala Asn Arg Leu Phe Gly 
                85                  90                  95      


Glu Lys Ser Cys Asp Phe Leu Ser Ser Phe Arg Asp Ser Cys Gln Lys 
            100                 105                 110         


Phe Tyr Gln Ala Glu Met Glu Glu Leu Asp Phe Ile Ser Ala Val Glu 
        115                 120                 125             


Lys Ser Arg Lys His Ile Asn Thr Trp Val Ala Glu Lys Thr Glu Gly 
    130                 135                 140                 


Lys Ile Ala Glu Leu Leu Ser Pro Gly Ser Val Asp Pro Leu Thr Arg 
145                 150                 155                 160 


Leu Val Leu Val Asn Ala Val Tyr Phe Arg Gly Asn Trp Asp Glu Gln 
                165                 170                 175     


Phe Asp Lys Glu Asn Thr Glu Glu Arg Leu Phe Lys Val Ser Lys Asn 
            180                 185                 190         


Glu Glu Lys Pro Val Gln Met Met Phe Lys Gln Ser Thr Phe Lys Lys 
        195                 200                 205             


Thr Tyr Ile Gly Glu Ile Phe Thr Gln Ile Leu Val Leu Pro Tyr Val 
    210                 215                 220                 


Gly Lys Glu Leu Asn Met Ile Ile Met Leu Pro Asp Glu Thr Thr Asp 
225                 230                 235                 240 


Leu Arg Thr Val Glu Lys Glu Leu Thr Tyr Glu Lys Phe Val Glu Trp 
                245                 250                 255     


Thr Arg Leu Asp Met Met Asp Glu Glu Glu Val Glu Val Ser Leu Pro 
            260                 265                 270         


Arg Phe Lys Leu Glu Glu Ser Tyr Asp Met Glu Ser Val Leu Arg Asn 
        275                 280                 285             


Leu Gly Met Thr Asp Ala Phe Glu Leu Gly Lys Ala Asp Phe Ser Gly 
    290                 295                 300                 


Met Ser Gln Thr Asp Leu Ser Leu Ser Lys Val Val His Lys Ser Phe 
305                 310                 315                 320 


Val Glu Val Asn Glu Glu Gly Thr Glu Ala Ala Ala Ala Thr Ala Ala 
                325                 330                 335     


Ile Met Met Met Arg Cys Ala Arg Phe Val Pro Arg Phe Cys Ala Asp 
            340                 345                 350         


His Pro Phe Leu Phe Phe Ile Gln His Ser Lys Thr Asn Gly Ile Leu 
        355                 360                 365             


Phe Cys Gly Arg Phe Ser Ser Pro 
    370                 375     


<210>  907
<211>  1617
<212>  DNA
<213>  Homo sapiens

<400>  907
gtggtggctt cggcagcggc ttcagcagat cggcggcatc agcggtagca ccagcactag       60

cagcatgttg agccgggcag tgtgcggcac cagcaggcag ctggctccgg ctttggggta      120

tctgggctcc aggcagaagc acagcctccc cgacctgccc tacgactacg gcgccctgga      180

acctcacatc aacgcgcaga tcatgcagct gcaccacagc aagcaccacg cggcctacgt      240

gaacaacctg aacgtcaccg aggagaagta ccaggaggcg ttggccaagg gtaggttcca      300

ggctgagcgg cgggaggcag tccccggcag aggcgacccc agggagccag gccccatacg      360

gacgggcctc tccgtggagg agaactcgct tcgtatttgt accggttccg agttttccag      420

gcacgatagt ctctctttta aacacatggt ctacctcatt gtagaaggag tgcctcgatg      480

ggtttgaaca cacttctgtc atctcaggga acttggggtc ctgcgaagga gcttgcctta      540

ctgttgtgag ccacattccg ttacacatat tgccagcact ggtgaattgt agggcctgaa      600

aagaaagctc tactgtgtca ctcgtttttt ttgcaaattg aaattgttct tgttgtataa      660

tatgctttgg ggaaatgttt ggtctctcag gtaggtgtgc cagccgtttg caggagggct      720

gagagcgcct gtccactggt ggccagacat catcgggtcc gcaggtgtct ctgagtgtca      780

gggtcacctc ctgatagaag tgggagtggt gtcttactgc caggtcacac tgaaggtggg      840

agacaggagg acactactcc gtgctaggaa ccatggtcct tgtcatcttc ctgagagcaa      900

acggggtcgg gactccagcc taggacttgg agactccctg catccccagc taccctgcag      960

gtgaaacttc actgagccca cttgacttca ggtgggagag gaggaggcac accgttgtgg     1020

tgtgcgttac caaaaaagca gtaacctaac tgtggaacag ttcaggatct ttagacttga     1080

tacttttctt gatttccctt aggggtcaaa gttcacaagg aaaatagccc tttagtggga     1140

aactgaaaca ggcttgtttt tatttactat ttactcatat ttgtaatgca attaaaatat     1200

atgttgttaa cttttttttt tttttctcaa gagctcggtt gataaaacca ggggtatgtg     1260

gactttttga gtctgtgcct tttgggggtg tgtatgggaa tgttatgttt taacattttt     1320

tacaaaatag tattgtcttt ttaatttatt cgttagtggt ttgcacaagg aagataatcg     1380

atagtcatgt tttttagacg ctctgtattg cttggtaagc tacgtagtaa aaaatgttta     1440

cttttcctta aatgttttga atttcggggt tatgaaattt gttgagtaat ttttagacag     1500

tcacatcttg ttgactggag gcatctagtg gaaaaatgca gtatttcagc ctgattgtgt     1560

ttgaagtaaa tgattaaaag aggaggaagt taccacaaaa aaaaaaaaaa aaaaaaa        1617


<210>  908
<211>  222
<212>  PRT
<213>  Homo sapiens

<400>  908

Met Leu Ser Arg Ala Val Cys Gly Thr Ser Arg Gln Leu Ala Pro Ala 
1               5                   10                  15      


Leu Gly Tyr Leu Gly Ser Arg Gln Lys His Ser Leu Pro Asp Leu Pro 
            20                  25                  30          


Tyr Asp Tyr Gly Ala Leu Glu Pro His Ile Asn Ala Gln Ile Met Gln 
        35                  40                  45              


Leu His His Ser Lys His His Ala Ala Tyr Val Asn Asn Leu Asn Val 
    50                  55                  60                  


Thr Glu Glu Lys Tyr Gln Glu Ala Leu Ala Lys Gly Asp Val Thr Ala 
65                  70                  75                  80  


Gln Ile Ala Leu Gln Pro Ala Leu Lys Phe Asn Gly Gly Gly His Ile 
                85                  90                  95      


Asn His Ser Ile Phe Trp Thr Asn Leu Ser Pro Asn Gly Gly Gly Glu 
            100                 105                 110         


Pro Lys Gly Glu Leu Leu Glu Ala Ile Lys Arg Asp Phe Gly Ser Phe 
        115                 120                 125             


Asp Lys Phe Lys Glu Lys Leu Thr Ala Ala Ser Val Gly Val Gln Gly 
    130                 135                 140                 


Ser Gly Trp Gly Trp Leu Gly Phe Asn Lys Glu Arg Gly His Leu Gln 
145                 150                 155                 160 


Ile Ala Ala Cys Pro Asn Gln Asp Pro Leu Gln Gly Thr Thr Gly Leu 
                165                 170                 175     


Ile Pro Leu Leu Gly Ile Asp Val Trp Glu His Ala Tyr Tyr Leu Gln 
            180                 185                 190         


Tyr Lys Asn Val Arg Pro Asp Tyr Leu Lys Ala Ile Trp Asn Val Ile 
        195                 200                 205             


Asn Trp Glu Asn Val Thr Glu Arg Tyr Met Ala Cys Lys Lys 
    210                 215                 220         


<210>  909
<211>  140
<212>  PRT
<213>  Homo sapiens

<400>  909

Met Leu Ser Arg Ala Val Cys Gly Thr Ser Arg Gln Leu Ala Pro Ala 
1               5                   10                  15      


Leu Gly Tyr Leu Gly Ser Arg Gln Lys His Ser Leu Pro Asp Leu Pro 
            20                  25                  30          


Tyr Asp Tyr Gly Ala Leu Glu Pro His Ile Asn Ala Gln Ile Met Gln 
        35                  40                  45              


Leu His His Ser Lys His His Ala Ala Tyr Val Asn Asn Leu Asn Val 
    50                  55                  60                  


Thr Glu Glu Lys Tyr Gln Glu Ala Leu Ala Lys Gly Arg Phe Gln Ala 
65                  70                  75                  80  


Glu Arg Arg Glu Ala Val Pro Gly Arg Gly Asp Pro Arg Glu Pro Gly 
                85                  90                  95      


Pro Ile Arg Thr Gly Leu Ser Val Glu Glu Asn Ser Leu Arg Ile Cys 
            100                 105                 110         


Thr Gly Ser Glu Phe Ser Arg His Asp Ser Leu Ser Phe Lys His Met 
        115                 120                 125             


Val Tyr Leu Ile Val Glu Gly Val Pro Arg Trp Val 
    130                 135                 140 


<210>  910
<211>  2374
<212>  DNA
<213>  Homo sapiens

<400>  910
ggtggcggca tggcggagag cgaggccgag acccccagca ccccggggga gttcgagagc       60

aagtacttcg agttccatgg cgtgcggctg ccgcccttct gccgcgggaa gatggaggag      120

atcgccaact tcccggtgcg gcccagcgac gtgtggatcg tcacctaccc caagtccggc      180

accagcttgc tgcaggaggt ggtctacttg gtgagccagg gcgctgaccc cgatgagatc      240

ggcttgatga acatcgacga gcagctcccg gtcctggagt acccacagcc gggcctggac      300

atcatcaagg aactgacctc tccccgcctc atcaagagcc acctgcccta ccgctttctg      360

ccctctgacc tccacaatgg agactcaaag gtcatctata tggctcgcaa ccccaaggat      420

ctggtggtgt cttattatca gttccaccgc tctctgcgga ccatgagcta ccgaggcacc      480

tttcaagaat tctgccggag gtttatgaat gataagctgg gctacggctc ctggtttgag      540

cacgtgcagg agttctggga gcaccgcatg gactcgaacg tgctttttct caagtatgaa      600

gacatgcatc gggacctggt gacgatggtg gagcagctgg ccagattcct gggggtgtcc      660

tgtgacaagg cccagctgga agccctgacg gagcactgcc accagctggt ggaccagtgc      720

tgcagcgctg aggccctgcc cgtgggccgg ggaagagttg ggctgtggaa ggacatcttc      780

accgtctcca tgaatgagaa gtttgacttg gtgtataaac agaagatggg aaagtgtgac      840

ctcacgtttg acttttattt ataataacag aaacaacaac ctgcatgctc acaataccca      900

gacagtctac tagccaaaag tcctgtatgc attcatttat tccttgctgg acaaactctg      960

gaagcagcgt gtgaaacagc gggggaaggg aagagcggcg tgagcggagg gagtgtgatg     1020

attcccaacc gaaagcagct gtctcgcctt tagaacgtgc agcctctcca tgtctgatta     1080

caaacagtct ccacattgca gttccaatgg cctggaccgt aaggataaag cctgtaatat     1140

atgcaactag aatgtctgcc ttttcaaccc cgtattattt attgtatttt atagagcttt     1200

tcactggaaa tctacataaa tgtcagtaaa ccaaataaaa gttcatttcc aaggggaatc     1260

aggagcgagc cacacccgaa tggtagaaag atctcagggt taactcttta tttttgtagt     1320

tttattatct aaggcacagc cattctgttc tcacttggtt ctgagatagt ggtgagaaca     1380

gaggatgagt tgggtctgtt ggggggaatc tggacacttg tttattctga cggagttcac     1440

ttcttcagaa ccttcctgaa atgagcagaa attgttcact aggtcttcag aatggacgtc     1500

cttctgccag agacttccag cgggcggctc caaaggccca atgcagagga gcccgcggag     1560

catgtgctga gggaagtctg cctggtgagg ctggcaggtg ggagtctaat gcagtcagga     1620

gcatttgcat gcagtgggtg gagagtcggc caccaaagga ccgagttgcg ctcggaattt     1680

gagctgaatt ccacagcctt actttgtttc ctgaagtgat agcctactaa tgctggcaag     1740

cagatgctta atagtaaatt tctaaaatcc ccgggtcttt atcattcagt ttgttctgtg     1800

cacctgaggc gctcagccgt gggaggacca ttttgcgagt gtagccctgt ttcactcgga     1860

tcaggttggc acggccgcct gcgtgtctgt ccacctcatc cctccgtgta tctgagggag     1920

taaaggtgag gtctttattg cttcactgcc taattttctc acccacattc gctgaagcga     1980

tggagagtcg ggggccagta gccagccaac cccgtgggga ccggggttgt ctgtcattta     2040

tgtggctgga aagcacccaa agtggtggtc aggagggtcg ctgctgtgga aggggtctcc     2100

gttcttggtg ctgtatttga aacgggtgta gagagaagct tgtgttttgt ttgtaatggg     2160

gagaagcgtg gccaggcagg tggcacgtgg catcgcatgg tgggctcggc agcaccttgc     2220

ctgtgtttct gtgagggagg ctgctttctg tgaaatttca tttatatttt tctattttta     2280

gtactgtatg gatgttactg agcactacac atgatccttc tgtgcttgct tgcatcttta     2340

ataaagacat gttcccggaa aaaaaaaaaa aaaa                                 2374


<210>  911
<211>  284
<212>  PRT
<213>  Homo sapiens

<400>  911

Met Ala Glu Ser Glu Ala Glu Thr Pro Ser Thr Pro Gly Glu Phe Glu 
1               5                   10                  15      


Ser Lys Tyr Phe Glu Phe His Gly Val Arg Leu Pro Pro Phe Cys Arg 
            20                  25                  30          


Gly Lys Met Glu Glu Ile Ala Asn Phe Pro Val Arg Pro Ser Asp Val 
        35                  40                  45              


Trp Ile Val Thr Tyr Pro Lys Ser Gly Thr Ser Leu Leu Gln Glu Val 
    50                  55                  60                  


Val Tyr Leu Val Ser Gln Gly Ala Asp Pro Asp Glu Ile Gly Leu Met 
65                  70                  75                  80  


Asn Ile Asp Glu Gln Leu Pro Val Leu Glu Tyr Pro Gln Pro Gly Leu 
                85                  90                  95      


Asp Ile Ile Lys Glu Leu Thr Ser Pro Arg Leu Ile Lys Ser His Leu 
            100                 105                 110         


Pro Tyr Arg Phe Leu Pro Ser Asp Leu His Asn Gly Asp Ser Lys Val 
        115                 120                 125             


Ile Tyr Met Ala Arg Asn Pro Lys Asp Leu Val Val Ser Tyr Tyr Gln 
    130                 135                 140                 


Phe His Arg Ser Leu Arg Thr Met Ser Tyr Arg Gly Thr Phe Gln Glu 
145                 150                 155                 160 


Phe Cys Arg Arg Phe Met Asn Asp Lys Leu Gly Tyr Gly Ser Trp Phe 
                165                 170                 175     


Glu His Val Gln Glu Phe Trp Glu His Arg Met Asp Ser Asn Val Leu 
            180                 185                 190         


Phe Leu Lys Tyr Glu Asp Met His Arg Asp Leu Val Thr Met Val Glu 
        195                 200                 205             


Gln Leu Ala Arg Phe Leu Gly Val Ser Cys Asp Lys Ala Gln Leu Glu 
    210                 215                 220                 


Ala Leu Thr Glu His Cys His Gln Leu Val Asp Gln Cys Cys Asn Ala 
225                 230                 235                 240 


Glu Ala Leu Pro Val Gly Arg Gly Arg Val Gly Leu Trp Lys Asp Ile 
                245                 250                 255     


Phe Thr Val Ser Met Asn Glu Lys Phe Asp Leu Val Tyr Lys Gln Lys 
            260                 265                 270         


Met Gly Lys Cys Asp Leu Thr Phe Asp Phe Tyr Leu 
        275                 280                 


<210>  912
<211>  284
<212>  PRT
<213>  Homo sapiens

<400>  912

Met Ala Glu Ser Glu Ala Glu Thr Pro Ser Thr Pro Gly Glu Phe Glu 
1               5                   10                  15      


Ser Lys Tyr Phe Glu Phe His Gly Val Arg Leu Pro Pro Phe Cys Arg 
            20                  25                  30          


Gly Lys Met Glu Glu Ile Ala Asn Phe Pro Val Arg Pro Ser Asp Val 
        35                  40                  45              


Trp Ile Val Thr Tyr Pro Lys Ser Gly Thr Ser Leu Leu Gln Glu Val 
    50                  55                  60                  


Val Tyr Leu Val Ser Gln Gly Ala Asp Pro Asp Glu Ile Gly Leu Met 
65                  70                  75                  80  


Asn Ile Asp Glu Gln Leu Pro Val Leu Glu Tyr Pro Gln Pro Gly Leu 
                85                  90                  95      


Asp Ile Ile Lys Glu Leu Thr Ser Pro Arg Leu Ile Lys Ser His Leu 
            100                 105                 110         


Pro Tyr Arg Phe Leu Pro Ser Asp Leu His Asn Gly Asp Ser Lys Val 
        115                 120                 125             


Ile Tyr Met Ala Arg Asn Pro Lys Asp Leu Val Val Ser Tyr Tyr Gln 
    130                 135                 140                 


Phe His Arg Ser Leu Arg Thr Met Ser Tyr Arg Gly Thr Phe Gln Glu 
145                 150                 155                 160 


Phe Cys Arg Arg Phe Met Asn Asp Lys Leu Gly Tyr Gly Ser Trp Phe 
                165                 170                 175     


Glu His Val Gln Glu Phe Trp Glu His Arg Met Asp Ser Asn Val Leu 
            180                 185                 190         


Phe Leu Lys Tyr Glu Asp Met His Arg Asp Leu Val Thr Met Val Glu 
        195                 200                 205             


Gln Leu Ala Arg Phe Leu Gly Val Ser Cys Asp Lys Ala Gln Leu Glu 
    210                 215                 220                 


Ala Leu Thr Glu His Cys His Gln Leu Val Asp Gln Cys Cys Ser Ala 
225                 230                 235                 240 


Glu Ala Leu Pro Val Gly Arg Gly Arg Val Gly Leu Trp Lys Asp Ile 
                245                 250                 255     


Phe Thr Val Ser Met Asn Glu Lys Phe Asp Leu Val Tyr Lys Gln Lys 
            260                 265                 270         


Met Gly Lys Cys Asp Leu Thr Phe Asp Phe Tyr Leu 
        275                 280                 


<210>  913
<211>  1625
<212>  DNA
<213>  Homo sapiens

<400>  913
gtctcggcga gggagtcatc aagctttggt gtatgtgttg gccggttctg aagtcttgaa       60

gaagctctgc tgaggaagac caaagcagca ctcgttgcca attagggaat ggaccgtttg      120

ggttccttta gcaatgatcc ctctgataag ccaccttgcc gaggctgctc ctcctacctc      180

atggagcctt atatcaagtg tgctgaatgt gggccacctc cttttttcct ctgcttgcag      240

tgtttcactc gaggctttga gtacaagaaa catcaaagcg atcatactta tgaaataatg      300

acttcagatt ttcctgtcct tgatcccagc tggactgctc aagaagaaat ggccctttta      360

gaagctgtga tggactgtgg ctttggaaat tggcaggatg tagccaatca aatgtgcacc      420

aagaccaagg aggagtgtga gaagcactat atgaagcatt tcatcaataa ccctctgttt      480

gcatctaccc tgctgaacct gaaacaagca gaggaagcaa aaactgctga cacagccatt      540

ccatttcact ctacagatga ccctccccga cctacctttg actccttgct ttctcgggac      600

atggccgggt acatgccagc tcgagcagat ttcattgagg aatttgacaa ttatgcagaa      660

tgggacttga gagacattga ttttgttgaa gatgactcgg acattttaca tgctctgaag      720

atggctgtgg tagatatcta tcattccagg ttaaaggaga gacaaagacg aaaaaaaatt      780

ataagagacc atggattaat caaccttaga aagtttcaat taatggaacg gcggtatccc      840

aaggaggtcc aggacctgta tgaaacaatg aggcgatttg caagaattgt ggggccagtg      900

gaacatgaca aattcattga aagccatgca ttggaatttg aactccgaag ggaaatcaag      960

aggctccaag aatacaggac agcaggcatt accaattttt gtagtgccag aacctacgat     1020

cacctcaaga agacacggga ggaagagcgc cttaaacgca ctatgctctc agaagttctc     1080

cagtatatcc aggacagtag tgcttgccag cagtggctcc gccggcaagc tgacattgat     1140

tccggcctga gtccttccat tccaatggct tcgaattcag gtagacggag tgcaccaccc     1200

ttgaacctca ctggcctccc tggcacagag aagctgaatg aaaaagaaaa ggagctctgt     1260

cagatggtga ggttggtccc tggagcctat ttagaataca aatctgctct attgaacgaa     1320

tgtaacaagc aaggaggctt aagactggcg caggcaagag cactcatcaa gatagatgtg     1380

aacaaaaccc ggaaaatcta tgatttcctc atcagagaag gatacatcac taaaggctaa     1440

ggctccaaga gcttgggatc agaagtcaga agtttggaat gtggtgggtc aaaggacaat     1500

atgggtgggc attctggaga gttgtttttc agctgaattc tcatggtgaa aacaggggaa     1560

aggacaaagg aaaccttaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa     1620

aaaaa                                                                 1625


<210>  914
<211>  443
<212>  PRT
<213>  Homo sapiens

<400>  914

Met Asp Arg Leu Gly Ser Phe Ser Asn Asp Pro Ser Asp Lys Pro Pro 
1               5                   10                  15      


Cys Arg Gly Cys Ser Ser Tyr Leu Met Glu Pro Tyr Ile Lys Cys Ala 
            20                  25                  30          


Glu Cys Gly Pro Pro Pro Phe Phe Leu Cys Leu Gln Cys Phe Thr Arg 
        35                  40                  45              


Gly Phe Glu Tyr Lys Lys His Gln Ser Asp His Thr Tyr Glu Ile Met 
    50                  55                  60                  


Thr Ser Asp Phe Pro Val Leu Asp Pro Ser Trp Thr Ala Gln Glu Glu 
65                  70                  75                  80  


Met Ala Leu Leu Glu Ala Val Met Asp Cys Gly Phe Gly Asn Trp Gln 
                85                  90                  95      


Asp Val Ala Asn Gln Met Cys Thr Lys Thr Lys Glu Glu Cys Glu Lys 
            100                 105                 110         


His Tyr Met Lys His Phe Ile Asn Asn Pro Leu Phe Ala Ser Thr Leu 
        115                 120                 125             


Leu Asn Leu Lys Gln Ala Glu Glu Ala Lys Thr Ala Asp Thr Ala Ile 
    130                 135                 140                 


Pro Phe His Ser Thr Asp Asp Pro Pro Arg Pro Thr Phe Asp Ser Leu 
145                 150                 155                 160 


Leu Ser Arg Asp Met Ala Gly Tyr Met Pro Ala Arg Ala Asp Phe Ile 
                165                 170                 175     


Glu Glu Phe Asp Asn Tyr Ala Glu Trp Asp Leu Arg Asp Ile Asp Phe 
            180                 185                 190         


Val Glu Asp Asp Ser Asp Ile Leu His Ala Leu Lys Met Ala Val Val 
        195                 200                 205             


Asp Ile Tyr His Ser Arg Leu Lys Glu Arg Gln Arg Arg Lys Lys Ile 
    210                 215                 220                 


Ile Arg Asp His Gly Leu Ile Asn Leu Arg Lys Phe Gln Leu Met Glu 
225                 230                 235                 240 


Arg Arg Tyr Pro Lys Glu Val Gln Asp Leu Tyr Glu Thr Met Arg Arg 
                245                 250                 255     


Phe Ala Arg Ile Val Gly Pro Val Glu His Asp Lys Phe Ile Glu Ser 
            260                 265                 270         


His Ala Leu Glu Phe Glu Leu Arg Arg Glu Ile Lys Arg Leu Gln Glu 
        275                 280                 285             


Tyr Arg Thr Ala Gly Ile Thr Asn Phe Cys Ser Ala Arg Thr Tyr Asp 
    290                 295                 300                 


His Leu Lys Lys Thr Arg Glu Glu Glu Arg Leu Lys Arg Thr Met Leu 
305                 310                 315                 320 


Ser Glu Val Leu Gln Tyr Ile Gln Asp Ser Ser Ala Cys Gln Gln Trp 
                325                 330                 335     


Leu Arg Arg Gln Ala Asp Ile Asp Ser Gly Leu Ser Pro Ser Ile Pro 
            340                 345                 350         


Met Ala Ser Asn Ser Gly Arg Arg Ser Ala Pro Pro Leu Asn Leu Thr 
        355                 360                 365             


Gly Leu Pro Gly Thr Glu Lys Leu Asn Glu Lys Glu Lys Glu Leu Cys 
    370                 375                 380                 


Gln Met Val Arg Leu Val Pro Gly Ala Tyr Leu Glu Tyr Lys Ser Ala 
385                 390                 395                 400 


Leu Leu Asn Glu Cys Asn Lys Gln Gly Gly Leu Arg Leu Ala Gln Ala 
                405                 410                 415     


Arg Ala Leu Ile Lys Ile Asp Val Asn Lys Thr Arg Lys Ile Tyr Asp 
            420                 425                 430         


Phe Leu Ile Arg Glu Gly Tyr Ile Thr Lys Gly 
        435                 440             


<210>  915
<211>  443
<212>  PRT
<213>  Homo sapiens

<400>  915

Met Asp Arg Leu Gly Ser Phe Ser Asn Asp Pro Ser Asp Lys Pro Pro 
1               5                   10                  15      


Cys Arg Gly Cys Ser Ser Tyr Leu Met Glu Pro Tyr Ile Lys Cys Ala 
            20                  25                  30          


Glu Cys Gly Pro Pro Pro Phe Phe Leu Cys Leu Gln Cys Phe Thr Arg 
        35                  40                  45              


Gly Phe Glu Tyr Lys Lys His Gln Ser Asp His Thr Tyr Glu Ile Met 
    50                  55                  60                  


Thr Ser Asp Phe Pro Val Leu Asp Pro Ser Trp Thr Ala Gln Glu Glu 
65                  70                  75                  80  


Met Ala Leu Leu Glu Ala Val Met Asp Cys Gly Phe Gly Asn Trp Gln 
                85                  90                  95      


Asp Val Ala Asn Gln Met Cys Thr Lys Thr Lys Glu Glu Cys Glu Lys 
            100                 105                 110         


His Tyr Met Lys His Phe Ile Asn Asn Pro Leu Phe Ala Ser Thr Leu 
        115                 120                 125             


Leu Asn Leu Lys Gln Ala Glu Glu Ala Lys Thr Ala Asp Thr Ala Ile 
    130                 135                 140                 


Pro Phe His Ser Thr Asp Asp Pro Pro Arg Pro Thr Phe Asp Ser Leu 
145                 150                 155                 160 


Leu Ser Arg Asp Met Ala Gly Tyr Met Pro Ala Arg Ala Asp Phe Ile 
                165                 170                 175     


Glu Glu Phe Asp Asn Tyr Ala Glu Trp Asp Leu Arg Asp Ile Asp Phe 
            180                 185                 190         


Val Glu Asp Asp Ser Asp Ile Leu His Ala Leu Lys Met Ala Val Val 
        195                 200                 205             


Asp Ile Tyr His Ser Arg Leu Lys Glu Arg Gln Arg Arg Lys Lys Ile 
    210                 215                 220                 


Ile Arg Asp His Gly Leu Ile Asn Leu Arg Lys Phe Gln Leu Met Glu 
225                 230                 235                 240 


Arg Arg Tyr Pro Lys Glu Val Gln Asp Leu Tyr Glu Thr Met Arg Arg 
                245                 250                 255     


Phe Ala Arg Ile Val Gly Pro Val Glu His Asp Lys Phe Ile Glu Ser 
            260                 265                 270         


His Ala Leu Glu Phe Glu Leu Arg Arg Glu Ile Lys Arg Leu Gln Glu 
        275                 280                 285             


Tyr Arg Thr Ala Gly Ile Thr Asn Phe Cys Ser Ala Arg Thr Tyr Asp 
    290                 295                 300                 


His Leu Lys Lys Thr Arg Glu Glu Glu Arg Leu Lys Arg Thr Met Leu 
305                 310                 315                 320 


Ser Glu Val Leu Gln Tyr Ile Gln Asp Ser Ser Ala Cys Gln Gln Trp 
                325                 330                 335     


Leu Arg Arg Gln Ala Asp Ile Asp Ser Gly Leu Ser Pro Ser Ile Pro 
            340                 345                 350         


Met Ala Ser Asn Ser Gly Arg Arg Ser Ala Pro Pro Leu Asn Leu Thr 
        355                 360                 365             


Gly Leu Pro Gly Thr Glu Lys Leu Asn Glu Lys Glu Lys Glu Leu Cys 
    370                 375                 380                 


Gln Met Val Arg Leu Val Pro Gly Ala Tyr Leu Glu Tyr Lys Ser Ala 
385                 390                 395                 400 


Leu Leu Asn Glu Cys Asn Lys Gln Gly Gly Leu Arg Leu Ala Gln Ala 
                405                 410                 415     


Arg Ala Leu Ile Lys Ile Asp Val Asn Lys Thr Arg Lys Ile Tyr Asp 
            420                 425                 430         


Phe Leu Ile Arg Glu Gly Tyr Ile Thr Lys Gly 
        435                 440             


<210>  916
<211>  1395
<212>  DNA
<213>  Homo sapiens

<400>  916
cggagtgcaa gtgagcttct cggctgcccc gcgggccggg gtgcggagcc gacatgcgcc       60

cgcttctcgg cctccttctg gtcttcgccg gctgcacctt cgccttgtac ttgctgtcga      120

cgcgactgcc ccgcgggcgg agactgggct ccaccgagga ggctggaggc aggtcgctgt      180

ggttcccctc cgacctggca gagctgcggg agctctctga ggtccttcga gagtaccgga      240

aggagcacca ggcctacgtg ttcctgctct tctgcggcgc ctacctctac aaacagggct      300

ttgccatccc cggctccagc ttcctgaatg ttttagctgg tgccttgttt gggccatggc      360

tggggcttct gctgtgctgt gtgttgacct cggtgggtgc cacatgctgc tacctgctct      420

ccagtatttt tggcaaacag ttggtggtgt cctactttcc tgataaagtg gccctgctgc      480

agagaaaggt ggaggagaac agaaacagct tgtttttttt cttattgttt ttgagacttt      540

tccccatgac accaaactgg ttcttgaacc tctcggcccc aattctgaac attcccatcg      600

tgcagttctt cttctcagtt cttatcggtt tgatcccata taatttcatc tgtgtgcaga      660

cagggtccat cctgtcaacc ctaacctctc tggatgctct tttctcctgg gacactgtct      720

ttaagctgtt ggccattgcc atggtggcat taattcctgg aaccctcatt aaaaaattta      780

gtcagaaaca tctgcaattg aatgaaacaa gtactgctaa tcatatacac agtagaaaag      840

acacatgatc tggattttct gtttgccaca tccctggact cagttgctta tttgtgtaat      900

ggatgtggtc ctctaaagcc cctcattttt ttttgattgc cttctatagg tgatgtggac      960

actgtgcatc aatgtgcagt gtcttttcag aaaggacact ctgctcttga aggtgtatta     1020

catcaggttt tcaaaccagc cctggtgtag cagacactgc aacagatgcc tcctagaaaa     1080

tgctgtttgt ggccgggcgc ggtggctcac gcctgtaatc ccagcacttt gggaggccga     1140

ggccggtgat tcacaaggtc aggagttcaa gaccagcctg gccaagatgg tgaaatcctg     1200

tctctaataa aaatacaaaa attagccagg cgtggtggca ggcacctgta atcccagcta     1260

ctcgggaggc tgaggcagga gaattgcttg aaccaaggtg gcagaggttg cagtaagcca     1320

agatcacacc actgcactcc agcctgggtg atagagtgag acactgtctt gacaaaaaaa     1380

aaaaaaaaaa aaaaa                                                      1395


<210>  917
<211>  264
<212>  PRT
<213>  Homo sapiens

<400>  917

Met Arg Pro Leu Leu Gly Leu Leu Leu Val Phe Ala Gly Cys Thr Phe 
1               5                   10                  15      


Ala Leu Tyr Leu Leu Ser Thr Arg Leu Pro Arg Gly Arg Arg Leu Gly 
            20                  25                  30          


Ser Thr Glu Glu Ala Gly Gly Arg Ser Leu Trp Phe Pro Ser Asp Leu 
        35                  40                  45              


Ala Glu Leu Arg Glu Leu Ser Glu Val Leu Arg Glu Tyr Arg Lys Glu 
    50                  55                  60                  


His Gln Ala Tyr Val Phe Leu Leu Phe Cys Gly Ala Tyr Leu Tyr Lys 
65                  70                  75                  80  


Gln Gly Phe Ala Ile Pro Gly Ser Ser Phe Leu Asn Val Leu Ala Gly 
                85                  90                  95      


Ala Leu Phe Gly Pro Trp Leu Gly Leu Leu Leu Cys Cys Val Leu Thr 
            100                 105                 110         


Ser Val Gly Ala Thr Cys Cys Tyr Leu Leu Ser Ser Ile Phe Gly Lys 
        115                 120                 125             


Gln Leu Val Val Ser Tyr Phe Pro Asp Lys Val Ala Leu Leu Gln Arg 
    130                 135                 140                 


Lys Val Glu Glu Asn Arg Asn Ser Leu Phe Phe Phe Leu Leu Phe Leu 
145                 150                 155                 160 


Arg Leu Phe Pro Met Thr Pro Asn Trp Phe Leu Asn Leu Ser Ala Pro 
                165                 170                 175     


Ile Leu Asn Ile Pro Ile Val Gln Phe Phe Phe Ser Val Leu Ile Gly 
            180                 185                 190         


Leu Ile Pro Tyr Asn Phe Ile Cys Val Gln Thr Gly Ser Ile Leu Ser 
        195                 200                 205             


Thr Leu Thr Ser Leu Asp Ala Leu Phe Ser Trp Asp Thr Val Phe Lys 
    210                 215                 220                 


Leu Leu Ala Ile Ala Met Val Ala Leu Ile Pro Gly Thr Leu Ile Lys 
225                 230                 235                 240 


Lys Phe Ser Gln Lys His Leu Gln Leu Asn Glu Thr Ser Thr Ala Asn 
                245                 250                 255     


His Ile His Ser Arg Lys Asp Thr 
            260                 


<210>  918
<211>  264
<212>  PRT
<213>  Homo sapiens

<400>  918

Met Arg Pro Leu Leu Gly Leu Leu Leu Val Phe Ala Gly Cys Thr Phe 
1               5                   10                  15      


Ala Leu Tyr Leu Leu Ser Thr Arg Leu Pro Arg Gly Arg Arg Leu Gly 
            20                  25                  30          


Ser Thr Glu Glu Ala Gly Gly Arg Ser Leu Trp Phe Pro Ser Asp Leu 
        35                  40                  45              


Ala Glu Leu Arg Glu Leu Ser Glu Val Leu Arg Glu Tyr Arg Lys Glu 
    50                  55                  60                  


His Gln Ala Tyr Val Phe Leu Leu Phe Cys Gly Ala Tyr Leu Tyr Lys 
65                  70                  75                  80  


Gln Gly Phe Ala Ile Pro Gly Ser Ser Phe Leu Asn Val Leu Ala Gly 
                85                  90                  95      


Ala Leu Phe Gly Pro Trp Leu Gly Leu Leu Leu Cys Cys Val Leu Thr 
            100                 105                 110         


Ser Val Gly Ala Thr Cys Cys Tyr Leu Leu Ser Ser Ile Phe Gly Lys 
        115                 120                 125             


Gln Leu Val Val Ser Tyr Phe Pro Asp Lys Val Ala Leu Leu Gln Arg 
    130                 135                 140                 


Lys Val Glu Glu Asn Arg Asn Ser Leu Phe Phe Phe Leu Leu Phe Leu 
145                 150                 155                 160 


Arg Leu Phe Pro Met Thr Pro Asn Trp Phe Leu Asn Leu Ser Ala Pro 
                165                 170                 175     


Ile Leu Asn Ile Pro Ile Val Gln Phe Phe Phe Ser Val Leu Ile Gly 
            180                 185                 190         


Leu Ile Pro Tyr Asn Phe Ile Cys Val Gln Thr Gly Ser Ile Leu Ser 
        195                 200                 205             


Thr Leu Thr Ser Leu Asp Ala Leu Phe Ser Trp Asp Thr Val Phe Lys 
    210                 215                 220                 


Leu Leu Ala Ile Ala Met Val Ala Leu Ile Pro Gly Thr Leu Ile Lys 
225                 230                 235                 240 


Lys Phe Ser Gln Lys His Leu Gln Leu Asn Glu Thr Ser Thr Ala Asn 
                245                 250                 255     


His Ile His Ser Arg Lys Asp Thr 
            260                 


<210>  919
<211>  2881
<212>  DNA
<213>  Homo sapiens

<400>  919
ctggggttgg tgcgagcttc cagcttggcc gcagttggtt cgtagttcgg ctctggggtc       60

ttttgtgtcc gggtctggct tggctttgtg tccgcgagtt tttgttccgc tccgcagcgc      120

tcttcccggg caggagccgt gaggctcgga ggcggcagcg cggtccccgg ccaggagcaa      180

gcgcgccggc gtgagcggcg gcggcaaagg ctgtggggag ggggcttcgc agatccccga      240

gatgccggag ttcctggaag acccctcggt cctgacaaaa gacaagttga agagtgagtt      300

ggtcgccaac aatgtgacgc tgccggccgg ggagcagcgc aaagacgtgt acgtccagct      360

ctacctgcag cacctcacgg ctcgcaaccg gccgccgctc cccgccggca ccaacagcaa      420

ggggcccccg gacttctcca gtgacgaaga gcgcgagccc accccggtcc tcggctctgg      480

ggccgccgcc gcgggccgga gccgagcagc cgtcggcagg aaagccacaa aaaaaactga      540

taaacccaga caagaagata aagatgatct agatgtaaca gagctcacta atgaagatct      600

tttggatcag cttgtgaaat acggagtgaa tcctggtcct attgtgggaa caaccaggaa      660

gctatatgag aaaaagcttt tgaaactgag ggaacaagga acagaatcaa gatcttctac      720

tcctctgcca acaatttctt cttcagcaga aaatacaagg cagaatggaa gtaatgattc      780

tgacagatac agtgacaatg aagaagactc taaaatagag ctcaagcttg agaagagaga      840

accactaaag ggcagagcaa agactccagt aacactcaag caaagaagag ttgagcacaa      900

tcagagctat tctcaagctg gaataactga gactgaatgg acaagtggat cttcaaaagg      960

cggacctctg caggcattaa ctagggaatc tacaagaggg tcaagaagaa ctccaaggaa     1020

aagggtggaa acttcagaac attttcgtat agatggtcca gtaatttcag agagtactcc     1080

catagctgaa actataatgg cttcaagcaa cgaatcctta gttgtcaata gggtgactgg     1140

aaatttcaag catgcatctc ctattctgcc aatcactgaa ttctcagaca tacccagaag     1200

agcaccaaag aaaccattga caagagctga agtgggagaa aaaacagagg aaagaagagt     1260

agaaagggat attcttaagg aaatgttccc ctatgaagca tctacaccaa caggaattag     1320

tgctagttgc cgcagaccaa tcaaaggggc tgcaggccgg ccattagaac tcagtgattt     1380

caggatggag gagtcttttt catctaaata tgttcctaag tatgttccct tggcagatgt     1440

caagtcagaa aagacaaaaa agggacgctc cattcccgta tggataaaaa ttttgctgtt     1500

tgttgttgtg gcagtttttt tgtttttggt ctatcaagct atggaaacca accaagtaaa     1560

tcccttctct aattttcttc atgttgaccc tagaaaatcc aactgaatgg tatctctttg     1620

gcacgttcaa cttggtctcc tattttcaat aactgttgaa aaacatttgt gtacacttgt     1680

tgactccaag aactaaaaat aatgtgattt cgcctcaata aatgtagtat ttcattgaaa     1740

agcaaacaaa atatatataa atggacttca ttaaaatgtt tttgaacttt ggactagtag     1800

gagatcactt tgtgccatat gaataatctt ttttagctct ggaacttttt gtaggcttta     1860

tttttttaat gtgggcatct tatttcattt ttgaaaaaat gtatatgttt tttgtgtatt     1920

tgggaaacga agggtgaaac atggtagtat aatgtgaagc tacacattta aatacttaga     1980

attcttacag aaaagatttt aagaattatt ctctgctgaa taaaaactgc aaatatgtga     2040

aacataatga aattcagtaa gaggaaaagt aacttggttg tactttttgt aactgcaaca     2100

aagtttgatg gtgtttatga ggaaaagtac agcaataatc tcttctgtaa cctttattaa     2160

tagtaatgtt gttgtagccc tatcatactc actttttaag acacagtatc atgaaagtcc     2220

tatttcagta agacccattt acatacagta gatttttagc agagatcttt tagtgtaaca     2280

tacatatttt agagaattgt tggctagctg tacatgtttt gaaaagctgt ttagctagct     2340

ataaggctat aattggaaat ttgtattttt tatttacagc aaaacattta ttcagtcatc     2400

cagtttgcta ccaaaatatg ttttagataa gtgtgtgtat gtttgtttag aagttagaaa     2460

ttgtaaacac tggtcttatg tttcatttgg attcattatt gcattgtctt gttaccagaa     2520

acaaattttg ccgagctttt ttgccctata tttcccagca taatttgatt agaaagtaca     2580

aaaagggcca ggcgcggtgg cttacgcctg taatcccagc actttgggag gccagggcgg     2640

gtggatcacg aggtcaggag atcgagacca tcctggccaa catggtgaaa ccccgtctct     2700

actaaaaata caaaaaaatt agctgggcgt gatgatgtgc gcctgtagtc ctgtctacta     2760

gggagactga ggcaggagaa tcgtttgaac ccaggaggca gaggttgcag tgagcagaga     2820

ttacgtcact gcactgtagc ctggcgacag agcgagactc catctcaaaa aaaaaaaaaa     2880

a                                                                     2881


<210>  920
<211>  454
<212>  PRT
<213>  Homo sapiens

<400>  920

Met Pro Glu Phe Leu Glu Asp Pro Ser Val Leu Thr Lys Asp Lys Leu 
1               5                   10                  15      


Lys Ser Glu Leu Val Ala Asn Asn Val Thr Leu Pro Ala Gly Glu Gln 
            20                  25                  30          


Arg Lys Asp Val Tyr Val Gln Leu Tyr Leu Gln His Leu Thr Ala Arg 
        35                  40                  45              


Asn Arg Pro Pro Leu Pro Ala Gly Thr Asn Ser Lys Gly Pro Pro Asp 
    50                  55                  60                  


Phe Ser Ser Asp Glu Glu Arg Glu Pro Thr Pro Val Leu Gly Ser Gly 
65                  70                  75                  80  


Ala Ala Ala Ala Gly Arg Ser Arg Ala Ala Val Gly Arg Lys Ala Thr 
                85                  90                  95      


Lys Lys Thr Asp Lys Pro Arg Gln Glu Asp Lys Asp Asp Leu Asp Val 
            100                 105                 110         


Thr Glu Leu Thr Asn Glu Asp Leu Leu Asp Gln Leu Val Lys Tyr Gly 
        115                 120                 125             


Val Asn Pro Gly Pro Ile Val Gly Thr Thr Arg Lys Leu Tyr Glu Lys 
    130                 135                 140                 


Lys Leu Leu Lys Leu Arg Glu Gln Gly Thr Glu Ser Arg Ser Ser Thr 
145                 150                 155                 160 


Pro Leu Pro Thr Ile Ser Ser Ser Ala Glu Asn Thr Arg Gln Asn Gly 
                165                 170                 175     


Ser Asn Asp Ser Asp Arg Tyr Ser Asp Asn Glu Glu Asp Ser Lys Ile 
            180                 185                 190         


Glu Leu Lys Leu Glu Lys Arg Glu Pro Leu Lys Gly Arg Ala Lys Thr 
        195                 200                 205             


Pro Val Thr Leu Lys Gln Arg Arg Val Glu His Asn Gln Ser Tyr Ser 
    210                 215                 220                 


Gln Ala Gly Ile Thr Glu Thr Glu Trp Thr Ser Gly Ser Ser Lys Gly 
225                 230                 235                 240 


Gly Pro Leu Gln Ala Leu Thr Arg Glu Ser Thr Arg Gly Ser Arg Arg 
                245                 250                 255     


Thr Pro Arg Lys Arg Val Glu Thr Ser Glu His Phe Arg Ile Asp Gly 
            260                 265                 270         


Pro Val Ile Ser Glu Ser Thr Pro Ile Ala Glu Thr Ile Met Ala Ser 
        275                 280                 285             


Ser Asn Glu Ser Leu Val Val Asn Arg Val Thr Gly Asn Phe Lys His 
    290                 295                 300                 


Ala Ser Pro Ile Leu Pro Ile Thr Glu Phe Ser Asp Ile Pro Arg Arg 
305                 310                 315                 320 


Ala Pro Lys Lys Pro Leu Thr Arg Ala Glu Val Gly Glu Lys Thr Glu 
                325                 330                 335     


Glu Arg Arg Val Glu Arg Asp Ile Leu Lys Glu Met Phe Pro Tyr Glu 
            340                 345                 350         


Ala Ser Thr Pro Thr Gly Ile Ser Ala Ser Cys Arg Arg Pro Ile Lys 
        355                 360                 365             


Gly Ala Ala Gly Arg Pro Leu Glu Leu Ser Asp Phe Arg Met Glu Glu 
    370                 375                 380                 


Ser Phe Ser Ser Lys Tyr Val Pro Lys Tyr Val Pro Leu Ala Asp Val 
385                 390                 395                 400 


Lys Ser Glu Lys Thr Lys Lys Gly Arg Ser Ile Pro Val Trp Ile Lys 
                405                 410                 415     


Ile Leu Leu Phe Val Val Val Ala Val Phe Leu Phe Leu Val Tyr Gln 
            420                 425                 430         


Ala Met Glu Thr Asn Gln Val Asn Pro Phe Ser Asn Phe Leu His Val 
        435                 440                 445             


Asp Pro Arg Lys Ser Asn 
    450                 


<210>  921
<211>  454
<212>  PRT
<213>  Homo sapiens

<400>  921

Met Pro Glu Phe Leu Glu Asp Pro Ser Val Leu Thr Lys Asp Lys Leu 
1               5                   10                  15      


Lys Ser Glu Leu Val Ala Asn Asn Val Thr Leu Pro Ala Gly Glu Gln 
            20                  25                  30          


Arg Lys Asp Val Tyr Val Gln Leu Tyr Leu Gln His Leu Thr Ala Arg 
        35                  40                  45              


Asn Arg Pro Pro Leu Pro Ala Gly Thr Asn Ser Lys Gly Pro Pro Asp 
    50                  55                  60                  


Phe Ser Ser Asp Glu Glu Arg Glu Pro Thr Pro Val Leu Gly Ser Gly 
65                  70                  75                  80  


Ala Ala Ala Ala Gly Arg Ser Arg Ala Ala Val Gly Arg Lys Ala Thr 
                85                  90                  95      


Lys Lys Thr Asp Lys Pro Arg Gln Glu Asp Lys Asp Asp Leu Asp Val 
            100                 105                 110         


Thr Glu Leu Thr Asn Glu Asp Leu Leu Asp Gln Leu Val Lys Tyr Gly 
        115                 120                 125             


Val Asn Pro Gly Pro Ile Val Gly Thr Thr Arg Lys Leu Tyr Glu Lys 
    130                 135                 140                 


Lys Leu Leu Lys Leu Arg Glu Gln Gly Thr Glu Ser Arg Ser Ser Thr 
145                 150                 155                 160 


Pro Leu Pro Thr Ile Ser Ser Ser Ala Glu Asn Thr Arg Gln Asn Gly 
                165                 170                 175     


Ser Asn Asp Ser Asp Arg Tyr Ser Asp Asn Glu Glu Asp Ser Lys Ile 
            180                 185                 190         


Glu Leu Lys Leu Glu Lys Arg Glu Pro Leu Lys Gly Arg Ala Lys Thr 
        195                 200                 205             


Pro Val Thr Leu Lys Gln Arg Arg Val Glu His Asn Gln Ser Tyr Ser 
    210                 215                 220                 


Gln Ala Gly Ile Thr Glu Thr Glu Trp Thr Ser Gly Ser Ser Lys Gly 
225                 230                 235                 240 


Gly Pro Leu Gln Ala Leu Thr Arg Glu Ser Thr Arg Gly Ser Arg Arg 
                245                 250                 255     


Thr Pro Arg Lys Arg Val Glu Thr Ser Glu His Phe Arg Ile Asp Gly 
            260                 265                 270         


Pro Val Ile Ser Glu Ser Thr Pro Ile Ala Glu Thr Ile Met Ala Ser 
        275                 280                 285             


Ser Asn Glu Ser Leu Val Val Asn Arg Val Thr Gly Asn Phe Lys His 
    290                 295                 300                 


Ala Ser Pro Ile Leu Pro Ile Thr Glu Phe Ser Asp Ile Pro Arg Arg 
305                 310                 315                 320 


Ala Pro Lys Lys Pro Leu Thr Arg Ala Glu Val Gly Glu Lys Thr Glu 
                325                 330                 335     


Glu Arg Arg Val Glu Arg Asp Ile Leu Lys Glu Met Phe Pro Tyr Glu 
            340                 345                 350         


Ala Ser Thr Pro Thr Gly Ile Ser Ala Ser Cys Arg Arg Pro Ile Lys 
        355                 360                 365             


Gly Ala Ala Gly Arg Pro Leu Glu Leu Ser Asp Phe Arg Met Glu Glu 
    370                 375                 380                 


Ser Phe Ser Ser Lys Tyr Val Pro Lys Tyr Val Pro Leu Ala Asp Val 
385                 390                 395                 400 


Lys Ser Glu Lys Thr Lys Lys Gly Arg Ser Ile Pro Val Trp Ile Lys 
                405                 410                 415     


Ile Leu Leu Phe Val Val Val Ala Val Phe Leu Phe Leu Val Tyr Gln 
            420                 425                 430         


Ala Met Glu Thr Asn Gln Val Asn Pro Phe Ser Asn Phe Leu His Val 
        435                 440                 445             


Asp Pro Arg Lys Ser Asn 
    450                 


<210>  922
<211>  1764
<212>  DNA
<213>  Homo sapiens

<400>  922
agaattcggg caccaggaga aggaagccaa caggatccga cccggtgttt tgtgacaaag       60

gcaagacccc caggtctact tagagcaaag ttagtagagg aggcagctag gcgtggctct      120

cattccttcc cacagaatgg attataagtc gagcctgatc caggatggga atcccatgga      180

gaacttggag aagcagctga tctgccctat ctgcctggag atgtttacca agccagtggt      240

catcttgccg tgccagcaca acctgtgccg gaagtgtgcc aatgacatct tccaggctgc      300

aaatccctac tggaccagcc ggggcagctc agtgtccatg tctggaggcc gtttccgctg      360

ccccacctgc cgccacgagg tgatcatgga tcgtcacgga gtgtacggcc tgcagaggaa      420

cctgctggtg gagaacatca tcgacatcta caaacaggag tgctccagtc ggccgctgca      480

gaagggcagt caccccatgt gcaaggagca cgaagatgag aaaatcaaca tctactgtct      540

cacgtgtgag gtgcccacct gctccatgtg caaggtgttt gggatccaca aggcctgcga      600

ggtggcccca ttgcagagtg tcttccaggg acaaaagact gaactgaata actgtatctc      660

catgctggtg gcggggaatg accgtgtgca gaccatcatc actcagctgg aggattcccg      720

tcgagtgacc aaggagaaca gtcaccaggt aaaggaagag ctgagccaga agtttgacac      780

gttgtatgcc atcctggatg agaagaaaag tgagttgctg cagcggatca cgcaggagca      840

ggagaaaaag cttagcttca tcgaggccct catccagcag taccaggagc agctggacaa      900

gtccacaaag ctggtggaaa ctgccatcca gtccctggac gagcctgggg gagccacctt      960

cctcttgact gccaagcaac tcatcaaaag cattgtggaa gcttccaagg gctgccagct     1020

ggggaagaca gagcagggct ttgagaacat ggacttcttt actttggatt tagagcacat     1080

agcagacgcc ctgagagcca ttgactttgg gacagatgag gaagaggaag aattcattga     1140

agaagaagat caggaagagg aagagtccac agaagggaag gaagaaggac accagtaagg     1200

agctggatga atgagaggcc cccagatgca gagagactgg agagggtggg gaggggccca     1260

gcggccttgg tgacaggccc agggtgggag gggtcggggc ccctggaggg gcaatgggga     1320

ggtgatgtct tctctctgct cagagagcag ggactagggt aggaccctca ccgctgcgtc     1380

cagcagacac tgaaccagaa ttggaaacgt gcttgaaaca atcacacagg acacttttct     1440

acattggtgc aaaatggaat attttgtaca tttttaaaat gtgatttttg tatatacttg     1500

tatatgtatg ccaatttggt gctttttgta aaggaacttt tgtataataa tgcctggtca     1560

ttgggtgacc tgcgattgtc agaaagaggg gaaggaagcc aggttgatac agctgcccac     1620

ttcctttcct gagcaggagg atggggtagc actcacaggg acgatgtgct gtatttcagt     1680

gtctatccca gacatacggg gtggtaactg agtttgtgtt atatgttgtt ttaataaatg     1740

cacaatgctc tcttcctgtt cttc                                            1764


<210>  923
<211>  353
<212>  PRT
<213>  Homo sapiens

<400>  923

Met Asp Tyr Lys Ser Ser Leu Ile Gln Asp Gly Asn Pro Met Glu Asn 
1               5                   10                  15      


Leu Glu Lys Gln Leu Ile Cys Pro Ile Cys Leu Glu Met Phe Thr Lys 
            20                  25                  30          


Pro Val Val Ile Leu Pro Cys Gln His Asn Leu Cys Arg Lys Cys Ala 
        35                  40                  45              


Asn Asp Ile Phe Gln Ala Ala Asn Pro Tyr Trp Thr Ser Arg Gly Ser 
    50                  55                  60                  


Ser Val Ser Met Ser Gly Gly Arg Phe Arg Cys Pro Thr Cys Arg His 
65                  70                  75                  80  


Glu Val Ile Met Asp Arg His Gly Val Tyr Gly Leu Gln Arg Asn Leu 
                85                  90                  95      


Leu Val Glu Asn Ile Ile Asp Ile Tyr Lys Gln Glu Cys Ser Ser Arg 
            100                 105                 110         


Pro Leu Gln Lys Gly Ser His Pro Met Cys Lys Glu His Glu Asp Glu 
        115                 120                 125             


Lys Ile Asn Ile Tyr Cys Leu Thr Cys Glu Val Pro Thr Cys Ser Met 
    130                 135                 140                 


Cys Lys Val Phe Gly Ile His Lys Ala Cys Glu Val Ala Pro Leu Gln 
145                 150                 155                 160 


Ser Val Phe Gln Gly Gln Lys Thr Glu Leu Asn Asn Cys Ile Ser Met 
                165                 170                 175     


Leu Val Ala Gly Asn Asp Arg Val Gln Thr Ile Ile Thr Gln Leu Glu 
            180                 185                 190         


Asp Ser Arg Arg Val Thr Lys Glu Asn Ser His Gln Val Lys Glu Glu 
        195                 200                 205             


Leu Ser Gln Lys Phe Asp Thr Leu Tyr Ala Ile Leu Asp Glu Lys Lys 
    210                 215                 220                 


Ser Glu Leu Leu Gln Arg Ile Thr Gln Glu Gln Glu Lys Lys Leu Ser 
225                 230                 235                 240 


Phe Ile Glu Ala Leu Ile Gln Gln Tyr Gln Glu Gln Leu Asp Lys Ser 
                245                 250                 255     


Thr Lys Leu Val Glu Thr Ala Ile Gln Ser Leu Asp Glu Pro Gly Gly 
            260                 265                 270         


Ala Thr Phe Leu Leu Thr Ala Lys Gln Leu Ile Lys Ser Ile Val Glu 
        275                 280                 285             


Ala Ser Lys Gly Cys Gln Leu Gly Lys Thr Glu Gln Gly Phe Glu Asn 
    290                 295                 300                 


Met Asp Phe Phe Thr Leu Asp Leu Glu His Ile Ala Asp Ala Leu Arg 
305                 310                 315                 320 


Ala Ile Asp Phe Gly Thr Asp Glu Glu Glu Glu Glu Phe Ile Glu Glu 
                325                 330                 335     


Glu Asp Gln Glu Glu Glu Glu Ser Thr Glu Gly Lys Glu Glu Gly His 
            340                 345                 350         


Gln 
    


<210>  924
<211>  353
<212>  PRT
<213>  Homo sapiens

<400>  924

Met Asp Tyr Lys Ser Ser Leu Ile Gln Asp Gly Asn Pro Met Glu Asn 
1               5                   10                  15      


Leu Glu Lys Gln Leu Ile Cys Pro Ile Cys Leu Glu Met Phe Thr Lys 
            20                  25                  30          


Pro Val Val Ile Leu Pro Cys Gln His Asn Leu Cys Arg Lys Cys Ala 
        35                  40                  45              


Asn Asp Ile Phe Gln Ala Ala Asn Pro Tyr Trp Thr Ser Arg Gly Ser 
    50                  55                  60                  


Ser Val Ser Met Ser Gly Gly Arg Phe Arg Cys Pro Thr Cys Arg His 
65                  70                  75                  80  


Glu Val Ile Met Asp Arg His Gly Val Tyr Gly Leu Gln Arg Asn Leu 
                85                  90                  95      


Leu Val Glu Asn Ile Ile Asp Ile Tyr Lys Gln Glu Cys Ser Ser Arg 
            100                 105                 110         


Pro Leu Gln Lys Gly Ser His Pro Met Cys Lys Glu His Glu Asp Glu 
        115                 120                 125             


Lys Ile Asn Ile Tyr Cys Leu Thr Cys Glu Val Pro Thr Cys Ser Met 
    130                 135                 140                 


Cys Lys Val Phe Gly Ile His Lys Ala Cys Glu Val Ala Pro Leu Gln 
145                 150                 155                 160 


Ser Val Phe Gln Gly Gln Lys Thr Glu Leu Asn Asn Cys Ile Ser Met 
                165                 170                 175     


Leu Val Ala Gly Asn Asp Arg Val Gln Thr Ile Ile Thr Gln Leu Glu 
            180                 185                 190         


Asp Ser Arg Arg Val Thr Lys Glu Asn Ser His Gln Val Lys Glu Glu 
        195                 200                 205             


Leu Ser Gln Lys Phe Asp Thr Leu Tyr Ala Ile Leu Asp Glu Lys Lys 
    210                 215                 220                 


Ser Glu Leu Leu Gln Arg Ile Thr Gln Glu Gln Glu Lys Lys Leu Ser 
225                 230                 235                 240 


Phe Ile Glu Ala Leu Ile Gln Gln Tyr Gln Glu Gln Leu Asp Lys Ser 
                245                 250                 255     


Thr Lys Leu Val Glu Thr Ala Ile Gln Ser Leu Asp Glu Pro Gly Gly 
            260                 265                 270         


Ala Thr Phe Leu Leu Thr Ala Lys Gln Leu Ile Lys Ser Ile Val Glu 
        275                 280                 285             


Ala Ser Lys Gly Cys Gln Leu Gly Lys Thr Glu Gln Gly Phe Glu Asn 
    290                 295                 300                 


Met Asp Phe Phe Thr Leu Asp Leu Glu His Ile Ala Asp Ala Leu Arg 
305                 310                 315                 320 


Ala Ile Asp Phe Gly Thr Asp Glu Glu Glu Glu Glu Phe Ile Glu Glu 
                325                 330                 335     


Glu Asp Gln Glu Glu Glu Glu Ser Thr Glu Gly Lys Glu Glu Gly His 
            340                 345                 350         


Gln 
    


<210>  925
<211>  1579
<212>  DNA
<213>  Homo sapiens

<400>  925
agcactctgc gcgcccgctc ttctgctgct gtttgtctac ttcctcctgc ttccccgccg       60

ccgccgccgc catcatgagg gaaatcgtgc acttgcaggc cgggcagtgc ggcaaccaaa      120

tcggcgccaa gttttgggag gtgatcagcg atgagcacgg catcgacccc acgggcacct      180

accacgggga cagcgacctg cagctggaac gcatcaacgt gtactacaat gaggccaccg      240

gcggcaagta cgtgccccgc gccgtgctcg tggatctgga gcccggcacc atggactccg      300

tgcgctcggg gcccttcggg cagatcttcc ggccggacaa cttcgttttc ggtcagagtg      360

gtgctgggaa caactgggcc aaggggcact acacagaagg cgcggagctg gtggactcgg      420

tgctggatgt tgtgagaaag gaggctgaga gctgtgactg cctgcagggt ttccagctga      480

cccactccct gggtgggggg actgggtctg ggatgggtac cctcctcatc agcaagatcc      540

gggaggagta cccagacagg atcatgaaca cgtttagtgt ggtgccttcg cccaaagtgt      600

cagacacagt ggtggagccc tacaacgcca ccctctcagt ccaccagctc gtagaaaaca      660

cagacgagac ctactgcatt gataacgaag ctctctacga catttgcttc agaaccctaa      720

agctgaccac gcccacctat ggtgacctga acaacctggt gtctgctacc atgagtgggg      780

tcaccacctg cctgcgcttc ccaggccagc tcaatgctga cctgcggaag ctggctgtga      840

acatggtccc gtttccccgg ctgcacttct tcatgcccgg ctttgcccca ctgaccagcc      900

ggggcagcca gcagtaccgg gcgctgaccg tgcccgagct cacccagcag atgtttgatg      960

ccaagaacat gatggctgcc tgcgaccccc gccatggccg ctacctgacg gttgccgccg     1020

tgttcagggg ccgcatgtcc atgaaggagg tggatgagca aatgcttaat gtccaaaaca     1080

aaaacagcag ctattttgtt gagtggatcc ccaacaatgt gaaaacggct gtctgtgaca     1140

tcccacctcg ggggctaaaa atgtccgcca ccttcattgg caacagcacg gccatccagg     1200

agctgttcaa gcgcatctcc gagcagttca cggccatgtt ccggcgcaag gccttcctgc     1260

actggtacac gggcgagggc atggacgaga tggagttcac cgaggccgag agcaacatga     1320

atgacctggt gtccgagtac cagcagtacc aggatgccac agccgaggag gagggcgagt     1380

tcgaggagga ggctgaggag gaggtggcct agagccttca gtcactgggg aaagcaggga     1440

agcagtgtga actctttatt cactcccagc ctgtcctgtg gcctgtccca ctgtgtgcac     1500

ttgctgtttt ccctgtccac atccatgcta tacagacacc accattaaag cattttcata     1560

gtgaaaaaaa aaaaaaaaa                                                  1579


<210>  926
<211>  445
<212>  PRT
<213>  Homo sapiens

<400>  926

Met Arg Glu Ile Val His Leu Gln Ala Gly Gln Cys Gly Asn Gln Ile 
1               5                   10                  15      


Gly Ala Lys Phe Trp Glu Val Ile Ser Asp Glu His Gly Ile Asp Pro 
            20                  25                  30          


Thr Gly Thr Tyr His Gly Asp Ser Asp Leu Gln Leu Glu Arg Ile Asn 
        35                  40                  45              


Val Tyr Tyr Asn Glu Ala Thr Gly Gly Lys Tyr Val Pro Arg Ala Val 
    50                  55                  60                  


Leu Val Asp Leu Glu Pro Gly Thr Met Asp Ser Val Arg Ser Gly Pro 
65                  70                  75                  80  


Phe Gly Gln Ile Phe Arg Pro Asp Asn Phe Val Phe Gly Gln Ser Gly 
                85                  90                  95      


Ala Gly Asn Asn Trp Ala Lys Gly His Tyr Thr Glu Gly Ala Glu Leu 
            100                 105                 110         


Val Asp Ser Val Leu Asp Val Val Arg Lys Glu Ala Glu Ser Cys Asp 
        115                 120                 125             


Cys Leu Gln Gly Phe Gln Leu Thr His Ser Leu Gly Gly Gly Thr Gly 
    130                 135                 140                 


Ser Gly Met Gly Thr Leu Leu Ile Ser Lys Ile Arg Glu Glu Tyr Pro 
145                 150                 155                 160 


Asp Arg Ile Met Asn Thr Phe Ser Val Val Pro Ser Pro Lys Val Ser 
                165                 170                 175     


Asp Thr Val Val Glu Pro Tyr Asn Ala Thr Leu Ser Val His Gln Leu 
            180                 185                 190         


Val Glu Asn Thr Asp Glu Thr Tyr Cys Ile Asp Asn Glu Ala Leu Tyr 
        195                 200                 205             


Asp Ile Cys Phe Arg Thr Leu Lys Leu Thr Thr Pro Thr Tyr Gly Asp 
    210                 215                 220                 


Leu Asn His Leu Val Ser Ala Thr Met Ser Gly Val Thr Thr Cys Leu 
225                 230                 235                 240 


Arg Phe Pro Gly Gln Leu Asn Ala Asp Leu Arg Lys Leu Ala Val Asn 
                245                 250                 255     


Met Val Pro Phe Pro Arg Leu His Phe Phe Met Pro Gly Phe Ala Pro 
            260                 265                 270         


Leu Thr Ser Arg Gly Ser Gln Gln Tyr Arg Ala Leu Thr Val Pro Glu 
        275                 280                 285             


Leu Thr Gln Gln Met Phe Asp Ala Lys Asn Met Met Ala Ala Cys Asp 
    290                 295                 300                 


Pro Arg His Gly Arg Tyr Leu Thr Val Ala Ala Val Phe Arg Gly Arg 
305                 310                 315                 320 


Met Ser Met Lys Glu Val Asp Glu Gln Met Leu Asn Val Gln Asn Lys 
                325                 330                 335     


Asn Ser Ser Tyr Phe Val Glu Trp Ile Pro Asn Asn Val Lys Thr Ala 
            340                 345                 350         


Val Cys Asp Ile Pro Pro Arg Gly Leu Lys Met Ser Ala Thr Phe Ile 
        355                 360                 365             


Gly Asn Ser Thr Ala Ile Gln Glu Leu Phe Lys Arg Ile Ser Glu Gln 
    370                 375                 380                 


Phe Thr Ala Met Phe Arg Arg Lys Ala Phe Leu His Trp Tyr Thr Gly 
385                 390                 395                 400 


Glu Gly Met Asp Glu Met Glu Phe Thr Glu Ala Glu Ser Asn Met Asn 
                405                 410                 415     


Asp Leu Val Ser Glu Tyr Gln Gln Tyr Gln Asp Ala Thr Ala Glu Glu 
            420                 425                 430         


Glu Gly Glu Phe Glu Glu Glu Ala Glu Glu Glu Val Ala 
        435                 440                 445 


<210>  927
<211>  445
<212>  PRT
<213>  Homo sapiens

<400>  927

Met Arg Glu Ile Val His Leu Gln Ala Gly Gln Cys Gly Asn Gln Ile 
1               5                   10                  15      


Gly Ala Lys Phe Trp Glu Val Ile Ser Asp Glu His Gly Ile Asp Pro 
            20                  25                  30          


Thr Gly Thr Tyr His Gly Asp Ser Asp Leu Gln Leu Glu Arg Ile Asn 
        35                  40                  45              


Val Tyr Tyr Asn Glu Ala Thr Gly Gly Lys Tyr Val Pro Arg Ala Val 
    50                  55                  60                  


Leu Val Asp Leu Glu Pro Gly Thr Met Asp Ser Val Arg Ser Gly Pro 
65                  70                  75                  80  


Phe Gly Gln Ile Phe Arg Pro Asp Asn Phe Val Phe Gly Gln Ser Gly 
                85                  90                  95      


Ala Gly Asn Asn Trp Ala Lys Gly His Tyr Thr Glu Gly Ala Glu Leu 
            100                 105                 110         


Val Asp Ser Val Leu Asp Val Val Arg Lys Glu Ala Glu Ser Cys Asp 
        115                 120                 125             


Cys Leu Gln Gly Phe Gln Leu Thr His Ser Leu Gly Gly Gly Thr Gly 
    130                 135                 140                 


Ser Gly Met Gly Thr Leu Leu Ile Ser Lys Ile Arg Glu Glu Tyr Pro 
145                 150                 155                 160 


Asp Arg Ile Met Asn Thr Phe Ser Val Val Pro Ser Pro Lys Val Ser 
                165                 170                 175     


Asp Thr Val Val Glu Pro Tyr Asn Ala Thr Leu Ser Val His Gln Leu 
            180                 185                 190         


Val Glu Asn Thr Asp Glu Thr Tyr Cys Ile Asp Asn Glu Ala Leu Tyr 
        195                 200                 205             


Asp Ile Cys Phe Arg Thr Leu Lys Leu Thr Thr Pro Thr Tyr Gly Asp 
    210                 215                 220                 


Leu Asn Asn Leu Val Ser Ala Thr Met Ser Gly Val Thr Thr Cys Leu 
225                 230                 235                 240 


Arg Phe Pro Gly Gln Leu Asn Ala Asp Leu Arg Lys Leu Ala Val Asn 
                245                 250                 255     


Met Val Pro Phe Pro Arg Leu His Phe Phe Met Pro Gly Phe Ala Pro 
            260                 265                 270         


Leu Thr Ser Arg Gly Ser Gln Gln Tyr Arg Ala Leu Thr Val Pro Glu 
        275                 280                 285             


Leu Thr Gln Gln Met Phe Asp Ala Lys Asn Met Met Ala Ala Cys Asp 
    290                 295                 300                 


Pro Arg His Gly Arg Tyr Leu Thr Val Ala Ala Val Phe Arg Gly Arg 
305                 310                 315                 320 


Met Ser Met Lys Glu Val Asp Glu Gln Met Leu Asn Val Gln Asn Lys 
                325                 330                 335     


Asn Ser Ser Tyr Phe Val Glu Trp Ile Pro Asn Asn Val Lys Thr Ala 
            340                 345                 350         


Val Cys Asp Ile Pro Pro Arg Gly Leu Lys Met Ser Ala Thr Phe Ile 
        355                 360                 365             


Gly Asn Ser Thr Ala Ile Gln Glu Leu Phe Lys Arg Ile Ser Glu Gln 
    370                 375                 380                 


Phe Thr Ala Met Phe Arg Arg Lys Ala Phe Leu His Trp Tyr Thr Gly 
385                 390                 395                 400 


Glu Gly Met Asp Glu Met Glu Phe Thr Glu Ala Glu Ser Asn Met Asn 
                405                 410                 415     


Asp Leu Val Ser Glu Tyr Gln Gln Tyr Gln Asp Ala Thr Ala Glu Glu 
            420                 425                 430         


Glu Gly Glu Phe Glu Glu Glu Ala Glu Glu Glu Val Ala 
        435                 440                 445 


<210>  928
<211>  2368
<212>  DNA
<213>  Homo sapiens

<400>  928
ccacgcgtcc gaaaatgttt gaacaattgg atttcaaaca ttttcgtttt gtggagtggt       60

gctcaccaag tggtacagcc ctaagcaagt gaacacaaac acatttaagt gtattttgtc      120

tgattagatg ttagccagtt atgctatttc attcaaatgt ctgaaaaaat caattgacta      180

ttcccttttc ctaaagggca gagacagata atctcacttc cagagaaatg acttggagaa      240

aaaaaagtgt tggtcttttt gctcttttgt aattaaatcc ggatgtacct caaaagactt      300

aagactgtgg tgataagatg ctttcctcag cagaaaggag ggaaaaaaaa acaactggaa      360

ctcaaagctt gaaattctgt ggcaaaacat gagatgtcca ggattggagg ttgaaaagat      420

ttcactacag tgttctgcaa tagttggagc agataacttt cagtgtagcc acagccatgg      480

actccagatt tccagatttt caagacctgg acctggaacc cgaaagagct tgtcacgatg      540

cggcaggaac actggaggta gatttttttt tatttttgaa ttttgggact gttgaccttg      600

ctgtgagaaa agagacaacg actgagcaag cactaccacc agcactgtta ctgggaatta      660

gaagacctga gtttctgtcc agaccctcag tgcaaactga ggatgctcca tccaaagtga      720

attatgtcct gtgcctcctg attgctgagt gttcacctgg accttctgac taccttccct      780

gtgctattcc atcagcctac agacctggta cctggatttt tgcccgagat gattcctacc      840

accttactac tgacgaagac acccattcca gtggaccact gtgacccagg aggcattcag      900

ccatcatgat gtggccttta cctccactcc tgtcttgttc tacccagatt cagcacagcc      960

ctttatagtg aagtcagagt cctcaagcca aatagctaaa gctgttttat cacaacaaag     1020

gcctagtttg ttccatgagt gtgcatttca tttcttcagt taaagccttc agagacacac     1080

aataaatttg gaccagggga ttttttagtt attaatgctc tctgaagaaa ggcaacatct     1140

ttttgagagc agcattggac cacaccccac aatctcaaat gattgaaatt catgaacatc     1200

taggatcccg tgaaggtcac tggaccctgt tttttctact tcaaatcctg tagtagccta     1260

ctgaatgaga aaacatattc tgacccattg ggatcaaatc aaaggcacag tgaactcctc     1320

atagcatctt ctttggaatt actcaggaac cagaactttt tacacaaatg taagaaattc     1380

taccaaggag tccccttacc taacagcatc tcacaaggct gcaccagatt ccagaaaagg     1440

cttctcttga tacatcaagc attttgtgac cgacttattc ttagatcatt ggttttccaa     1500

aggctttgtg gccatgaagc cctttgagtg aaaactgtgc agaagcccag agtaaaagtg     1560

aagctgctct ggatgaagta gtgaagcaag agtaggggcc tgaatcctgc tacaactatc     1620

ttcctttacc accgtggtga cacctaaggg gacttcctta caacaccttg aactcttccg     1680

aacacagttt gaaaaccact gccccagaca gcaatatgtt tgacctgaat ggcattccaa     1740

tcttttctgt acctccactc agcacagttc atgttcagta gatgctgaac attcttagaa     1800

atactgtgtg tgaacttaga aaagtgcaag aagacaggca tgtctttgac cccaggaatg     1860

atcatttgct gaagatggtg tcaagtgaac ctagattaac agccctccac tccagatgga     1920

tatccagtga ttcctagaat gggatatagc cagagaacaa ttctatgcac cctacactga     1980

cagactccct taagcaacac cagatgctct actggtactt gaagtacatg actttgaagt     2040

cttgaccctc catgaatacc tgaattatca gcaagcgggt tttgaagctg gtgcctcatt     2100

gaggccatat tagagcaact tgtacatttg acctcttgtt atcagccatg gtactctact     2160

tcgtgtgcaa gagataacta tgaaagccaa attcaaatac tggcaacatt tcctaaaggg     2220

gctcaatatc tatcattcgt cttcttttcc aaactacaca tcactgtatg actcaaccag     2280

tagcagttat attgcccctt ggtttttatt cagtttaact actgtttcca agataaatga     2340

gctaataagc tttaaaaaaa aaaaaaaa                                        2368


<210>  929
<211>  135
<212>  PRT
<213>  Homo sapiens

<400>  929

Met Asp Ser Arg Phe Pro Asp Phe Gln Asp Leu Asp Leu Glu Pro Glu 
1               5                   10                  15      


Arg Ala Cys His Asp Ala Ala Gly Thr Leu Glu Val Asp Phe Phe Leu 
            20                  25                  30          


Phe Leu Asn Phe Gly Thr Val Asp Leu Ala Val Arg Lys Glu Thr Thr 
        35                  40                  45              


Thr Glu Gln Ala Leu Pro Pro Ala Leu Leu Leu Gly Ile Arg Arg Pro 
    50                  55                  60                  


Glu Phe Leu Ser Arg Pro Ser Val Gln Thr Glu Asp Ala Pro Ser Lys 
65                  70                  75                  80  


Val Asn Tyr Val Leu Cys Leu Leu Ile Ala Glu Cys Ser Pro Gly Pro 
                85                  90                  95      


Ser Asp Tyr Leu Pro Cys Ala Ile Pro Ser Ala Tyr Arg Pro Gly Thr 
            100                 105                 110         


Trp Ile Phe Ala Arg Asp Asp Ser Tyr His Leu Thr Thr Asp Glu Asp 
        115                 120                 125             


Thr His Ser Ser Gly Pro Leu 
    130                 135 


<210>  930
<211>  135
<212>  PRT
<213>  Homo sapiens

<400>  930

Met Asp Ser Arg Phe Pro Asp Phe Gln Asp Leu Asp Leu Glu Pro Glu 
1               5                   10                  15      


Arg Ala Cys His Asp Ala Ala Gly Thr Leu Glu Val Asp Phe Phe Leu 
            20                  25                  30          


Phe Leu Asn Phe Gly Thr Val Asp Leu Ala Val Arg Lys Glu Thr Thr 
        35                  40                  45              


Thr Glu Gln Ala Leu Pro Pro Ala Leu Leu Leu Gly Ile Arg Arg Pro 
    50                  55                  60                  


Glu Phe Leu Ser Arg Pro Ser Val Gln Thr Glu Asp Ala Pro Ser Lys 
65                  70                  75                  80  


Val Asn Tyr Val Leu Cys Leu Leu Ile Ala Glu Cys Ser Pro Gly Pro 
                85                  90                  95      


Ser Asp Tyr Leu Pro Cys Ala Ile Pro Ser Ala Tyr Arg Pro Gly Thr 
            100                 105                 110         


Trp Ile Phe Ala Arg Asp Asp Ser Tyr His Leu Thr Thr Asp Glu Asp 
        115                 120                 125             


Thr His Ser Ser Gly Pro Leu 
    130                 135 


<210>  931
<211>  1025
<212>  DNA
<213>  Homo sapiens

<400>  931
gggggaccta gctcgggacc ggcctggaga tggagttcga ctgcgagggc ctgagacggc       60

tgcttggcaa gtacaagttc agggacctaa ctgtggaaga actaaggaat gtaaatgtat      120

ttttcccaca tttcaaatat tccatggaca cctatgtttt taaagatagt tctcagaaag      180

acctgctgaa ttttactggc acaattcctg tgatgtatca gggtaataca tataacatac      240

caattcgttt ctggattttg gattctcacc ctttcgctcc ccctatttgc ttcttgaagc      300

caactgcaaa tatgggaatc ttagtcggaa aacatgtgga tgctcaaggc agaatatatt      360

tgccctatct ccaaaactgg agccatccta aatctgtcat tgttggatta attaaagaaa      420

tgattgccaa gtttcaagag gaacttccca tgtattctct atcatcatct gatgaggcac      480

ggcaggtaga cttgctagcc tatattgcaa aaatcactga aggtgtttca gatacaaatt      540

caaagagctg ggcaaatcat gagaataaaa cagtcaataa aattactgtg gttggaggtg      600

gagaactcgg tattgcctgc acattagcaa tttcagcaaa ggtggagtct cgctctgtta      660

cccaggctgg agtgtagtgg tacaatcttg gctcactaca gcctccgcct cctgggttca      720

agcgattctc ctgcctcagc ctccagagta gctgggacta caggcatgcg ccacgacgcc      780

cagctaattt ttgtattttt agcagagaca gggttttgcc atgttggcca ggctggtctc      840

gaacttctga cctcaagtga tccacctgcc ctggcctccc aaagtgctgg gattacaagt      900

gtgagccacc gtacctggcc tgctattacc tcttaattag aatttgagtt gtattcagtc      960

ttttgtcact aaataaatgc ttctataaac attccaaaaa aaaaaaaaaa aaaaaaaaaa     1020

aaaaa                                                                 1025


<210>  932
<211>  471
<212>  PRT
<213>  Homo sapiens

<400>  932

Met Glu Phe Asp Cys Glu Gly Leu Arg Arg Leu Leu Gly Lys Tyr Lys 
1               5                   10                  15      


Phe Arg Asp Leu Thr Val Glu Glu Leu Arg Asn Val Asn Val Phe Phe 
            20                  25                  30          


Pro His Phe Lys Tyr Ser Met Asp Thr Tyr Val Phe Lys Asp Ser Ser 
        35                  40                  45              


Gln Lys Asp Leu Leu Asn Phe Thr Gly Thr Ile Pro Val Met Tyr Gln 
    50                  55                  60                  


Gly Asn Thr Tyr Asn Ile Pro Ile Arg Phe Trp Ile Leu Asp Ser His 
65                  70                  75                  80  


Pro Phe Ala Pro Pro Ile Cys Phe Leu Lys Pro Thr Ala Asn Met Gly 
                85                  90                  95      


Ile Leu Val Gly Lys His Val Asp Ala Gln Gly Arg Ile Tyr Leu Pro 
            100                 105                 110         


Tyr Leu Gln Asn Trp Ser His Pro Lys Ser Val Ile Val Gly Leu Ile 
        115                 120                 125             


Lys Glu Met Ile Ala Lys Phe Gln Glu Glu Leu Pro Met Tyr Ser Leu 
    130                 135                 140                 


Ser Ser Ser Asp Glu Ala Arg Gln Val Asp Leu Leu Ala Tyr Ile Ala 
145                 150                 155                 160 


Lys Ile Thr Glu Gly Val Ser Asp Thr Asn Ser Lys Ser Trp Ala Asn 
                165                 170                 175     


His Glu Asn Lys Thr Val Asn Lys Ile Thr Val Val Gly Gly Gly Glu 
            180                 185                 190         


Leu Gly Ile Ala Cys Thr Leu Ala Ile Ser Ala Lys Gly Ile Ala Asp 
        195                 200                 205             


Arg Leu Val Leu Leu Asp Leu Ser Glu Gly Thr Lys Gly Ala Thr Met 
    210                 215                 220                 


Asp Leu Glu Ile Phe Asn Leu Pro Asn Val Glu Ile Ser Lys Asp Leu 
225                 230                 235                 240 


Ser Ala Ser Ala His Ser Lys Val Val Ile Phe Thr Val Asn Ser Leu 
                245                 250                 255     


Gly Ser Ser Gln Ser Tyr Leu Asp Val Val Gln Ser Asn Val Asp Met 
            260                 265                 270         


Phe Arg Ala Leu Val Pro Ala Leu Gly His Tyr Ser Gln His Ser Val 
        275                 280                 285             


Leu Leu Val Ala Ser Gln Pro Val Glu Ile Met Thr Tyr Val Thr Trp 
    290                 295                 300                 


Lys Leu Ser Thr Phe Pro Ala Asn Arg Val Ile Gly Ile Gly Cys Asn 
305                 310                 315                 320 


Leu Asp Ser Gln Arg Leu Gln Tyr Ile Ile Thr Asn Val Leu Lys Ala 
                325                 330                 335     


Gln Thr Ser Gly Lys Glu Val Trp Val Ile Gly Glu Gln Gly Glu Asp 
            340                 345                 350         


Lys Val Leu Thr Trp Ser Gly Gln Glu Glu Val Val Ser His Thr Ser 
        355                 360                 365             


Gln Val Gln Leu Ser Asn Arg Ala Met Glu Leu Leu Arg Val Lys Gly 
    370                 375                 380                 


Gln Arg Ser Trp Ser Val Gly Leu Ser Val Ala Asp Met Val Asp Ser 
385                 390                 395                 400 


Ile Val Asn Asn Lys Lys Lys Val His Ser Val Ser Ala Leu Ala Lys 
                405                 410                 415     


Gly Tyr Tyr Asp Ile Asn Ser Glu Val Phe Leu Ser Leu Pro Cys Ile 
            420                 425                 430         


Leu Gly Thr Asn Gly Val Ser Glu Val Ile Lys Thr Thr Leu Lys Glu 
        435                 440                 445             


Asp Thr Val Thr Glu Lys Leu Gln Ser Ser Ala Ser Ser Ile His Ser 
    450                 455                 460                 


Leu Gln Gln Gln Leu Lys Leu 
465                 470     


<210>  933
<211>  177
<212>  PRT
<213>  Homo sapiens

<400>  933

Met Asp Thr Tyr Val Phe Lys Asp Ser Ser Gln Lys Asp Leu Leu Asn 
1               5                   10                  15      


Phe Thr Gly Thr Ile Pro Val Met Tyr Gln Gly Asn Thr Tyr Asn Ile 
            20                  25                  30          


Pro Ile Arg Phe Trp Ile Leu Asp Ser His Pro Phe Ala Pro Pro Ile 
        35                  40                  45              


Cys Phe Leu Lys Pro Thr Ala Asn Met Gly Ile Leu Val Gly Lys His 
    50                  55                  60                  


Val Asp Ala Gln Gly Arg Ile Tyr Leu Pro Tyr Leu Gln Asn Trp Ser 
65                  70                  75                  80  


His Pro Lys Ser Val Ile Val Gly Leu Ile Lys Glu Met Ile Ala Lys 
                85                  90                  95      


Phe Gln Glu Glu Leu Pro Met Tyr Ser Leu Ser Ser Ser Asp Glu Ala 
            100                 105                 110         


Arg Gln Val Asp Leu Leu Ala Tyr Ile Ala Lys Ile Thr Glu Gly Val 
        115                 120                 125             


Ser Asp Thr Asn Ser Lys Ser Trp Ala Asn His Glu Asn Lys Thr Val 
    130                 135                 140                 


Asn Lys Ile Thr Val Val Gly Gly Gly Glu Leu Gly Ile Ala Cys Thr 
145                 150                 155                 160 


Leu Ala Ile Ser Ala Lys Val Glu Ser Arg Ser Val Thr Gln Ala Gly 
                165                 170                 175     


Val 
    


<210>  934
<211>  1912
<212>  DNA
<213>  Homo sapiens

<400>  934
ggtgacccgc ggctgggcgc ctcggccatg actgcggagc tgcagcagga cgacgcggcc       60

ggcgcggcag acggccacgg ctcgagctgc caaatgctgt taaatcaact gagagaaatc      120

acaggcattc aggacccttc ctttctccat gaagctctga aggccagtaa tggtgacatt      180

actcaggcag tcagccttct cactgatgag agagttaagg agcccagtca agacactgtt      240

gctacagaac catctgaagt agaggggagt gctgccaaca aggaagtatt agcaaaagtt      300

atagacctta ctcatgataa caaagatgat cttcaggctg ccattgcttt gagtctactg      360

gagtctccca aaattcaagc tgatggaaga gatcttaaca ggatgcatga agcaacctct      420

gcagaaacta aacgctcaaa gagaaaacgc tgtgaagtct ggggagaaaa ccccaatccc      480

aatgactgga ggagagttga tggttggcca gttgggctga aaaatgttgg caatacatgt      540

tggtttagtg ctgttattca gtctctcttt caattgcctg aatttcgaag acttgttctc      600

agttatagtc tgccacaaaa tgtacttgaa aattgtcgaa gtcatacaga aaagagaaat      660

atcatgttta tgcaagagct tcagtatttg tttgctctaa tgatgggatc aaatagaaaa      720

tttgtagacc cgtctgcagc cctggatcta ttaaagggag cattccgatc atctgaggaa      780

cagcagcaag atgtgagtga attcacacac aagctcctgg attggctaga ggacgcattc      840

cagctagctg ttaatgttaa cagtcccagg aacaaatctg aaaatccaat ggtgcagctg      900

ttctatggta ctttcctgac tgaaggggtt cgtgaaggaa aacccttttg taacaatgag      960

accttcggcc agtatcctct tcaggtaaac ggttatcgca acttagacga gtgtttggaa     1020

ggggccatgg tggagggtga tgttgagctt cttccctccg atcactcggt gaagtatgga     1080

caagagcgtt ggtttacaaa gctacctcca gtgttgacct ttgaactctc aagatttgag     1140

tttaatcagt cccttgggca gccagagaaa attcacaata agctggaatt tcctcagatt     1200

atttatatgg acaggtacat gtacaggagc aaggagctta ttcgaaataa gagagagtgt     1260

attcgaaagt tgaaggagga aataaaaatt ctgcagcaaa aattggaaag gtatgtgaaa     1320

tatggctcag gcccagctcg gttcccgctc ccggacatgc tgaaatatgt tattgaattt     1380

gctagtacaa aacctgcctc agaaagctgt ccacctgaaa gtgacacaca tatgacatta     1440

ccactttctt cagtgcactg ctcggtttct gaccagacat ccaaggaaag tacaagtaca     1500

gaaagctctt ctcaggatgt tgaaagtacc ttttcttctc ctgaagattc tttacccaag     1560

tctaaaccac tgacatcttc tcggtcttcc atggaaatgc cttcacagcc agctccacga     1620

acagtcacag atgaggagat aaattttgtt aagacctgtc ttcagagatg gaggagtgag     1680

attgaacaag atatacaaga tttaaagact tgtattgcaa gtactactca gactattgaa     1740

cagatgtact gcgatcctct ccttcgtcag gtagaatgaa aattgatggg aaagtagtca     1800

aggcatgtgc taatggtaga tacaaaaatc aaatttgata gttttctttt aaacccaatg     1860

ggaatccccc taagataaaa gaataaactt aagatataaa aaaaaaaaaa aa             1912


<210>  935
<211>  1077
<212>  PRT
<213>  Homo sapiens

<400>  935

Met Thr Ala Glu Leu Gln Gln Asp Asp Ala Ala Gly Ala Ala Asp Gly 
1               5                   10                  15      


His Gly Ser Ser Cys Gln Met Leu Leu Asn Gln Leu Arg Glu Ile Thr 
            20                  25                  30          


Gly Ile Gln Asp Pro Ser Phe Leu His Glu Ala Leu Lys Ala Ser Asn 
        35                  40                  45              


Gly Asp Ile Thr Gln Ala Val Ser Leu Leu Thr Asp Glu Arg Val Lys 
    50                  55                  60                  


Glu Pro Ser Gln Asp Thr Val Ala Thr Glu Pro Ser Glu Val Glu Gly 
65                  70                  75                  80  


Ser Ala Ala Asn Lys Glu Val Leu Ala Lys Val Ile Asp Leu Thr His 
                85                  90                  95      


Asp Asn Lys Asp Asp Leu Gln Ala Ala Ile Ala Leu Ser Leu Leu Glu 
            100                 105                 110         


Ser Pro Lys Ile Gln Ala Asp Gly Arg Asp Leu Asn Arg Met His Glu 
        115                 120                 125             


Ala Thr Ser Ala Glu Thr Lys Arg Ser Lys Arg Lys Arg Cys Glu Val 
    130                 135                 140                 


Trp Gly Glu Asn Pro Asn Pro Asn Asp Trp Arg Arg Val Asp Gly Trp 
145                 150                 155                 160 


Pro Val Gly Leu Lys Asn Val Gly Asn Thr Cys Trp Phe Ser Ala Val 
                165                 170                 175     


Ile Gln Ser Leu Phe Gln Leu Pro Glu Phe Arg Arg Leu Val Leu Ser 
            180                 185                 190         


Tyr Ser Leu Pro Gln Asn Val Leu Glu Asn Cys Arg Ser His Thr Glu 
        195                 200                 205             


Lys Arg Asn Ile Met Phe Met Gln Glu Leu Gln Tyr Leu Phe Ala Leu 
    210                 215                 220                 


Met Met Gly Ser Asn Arg Lys Phe Val Asp Pro Ser Ala Ala Leu Asp 
225                 230                 235                 240 


Leu Leu Lys Gly Ala Phe Arg Ser Ser Glu Glu Gln Gln Gln Asp Val 
                245                 250                 255     


Ser Glu Phe Thr His Lys Leu Leu Asp Trp Leu Glu Asp Ala Phe Gln 
            260                 265                 270         


Leu Ala Val Asn Val Asn Ser Pro Arg Asn Lys Ser Glu Asn Pro Met 
        275                 280                 285             


Val Gln Leu Phe Tyr Gly Thr Phe Leu Thr Glu Gly Val Arg Glu Gly 
    290                 295                 300                 


Lys Pro Phe Cys Asn Asn Glu Thr Phe Gly Gln Tyr Pro Leu Gln Val 
305                 310                 315                 320 


Asn Gly Tyr Arg Asn Leu Asp Glu Cys Leu Glu Gly Ala Met Val Glu 
                325                 330                 335     


Gly Asp Val Glu Leu Leu Pro Ser Asp His Ser Val Lys Tyr Gly Gln 
            340                 345                 350         


Glu Arg Trp Phe Thr Lys Leu Pro Pro Val Leu Thr Phe Glu Leu Ser 
        355                 360                 365             


Arg Phe Glu Phe Asn Gln Ser Leu Gly Gln Pro Glu Lys Ile His Asn 
    370                 375                 380                 


Lys Leu Glu Phe Pro Gln Ile Ile Tyr Met Asp Arg Tyr Met Tyr Arg 
385                 390                 395                 400 


Ser Lys Glu Leu Ile Arg Asn Lys Arg Glu Cys Ile Arg Lys Leu Lys 
                405                 410                 415     


Glu Glu Ile Lys Ile Leu Gln Gln Lys Leu Glu Arg Tyr Val Lys Tyr 
            420                 425                 430         


Gly Ser Gly Pro Ala Arg Phe Pro Leu Pro Asp Met Leu Lys Tyr Val 
        435                 440                 445             


Ile Glu Phe Ala Ser Thr Lys Pro Ala Ser Glu Ser Cys Pro Pro Glu 
    450                 455                 460                 


Ser Asp Thr His Met Thr Leu Pro Leu Ser Ser Val His Cys Ser Val 
465                 470                 475                 480 


Ser Asp Gln Thr Ser Lys Glu Ser Thr Ser Thr Glu Ser Ser Ser Gln 
                485                 490                 495     


Asp Val Glu Ser Thr Phe Ser Ser Pro Glu Asp Ser Leu Pro Lys Ser 
            500                 505                 510         


Lys Pro Leu Thr Ser Ser Arg Ser Ser Met Glu Met Pro Ser Gln Pro 
        515                 520                 525             


Ala Pro Arg Thr Val Thr Asp Glu Glu Ile Asn Phe Val Lys Thr Cys 
    530                 535                 540                 


Leu Gln Arg Trp Arg Ser Glu Ile Glu Gln Asp Ile Gln Asp Leu Lys 
545                 550                 555                 560 


Thr Cys Ile Ala Ser Thr Thr Gln Thr Ile Glu Gln Met Tyr Cys Asp 
                565                 570                 575     


Pro Leu Leu Arg Gln Val Pro Tyr Arg Leu His Ala Val Leu Val His 
            580                 585                 590         


Glu Gly Gln Ala Asn Ala Gly His Tyr Trp Ala Tyr Ile Tyr Asn Gln 
        595                 600                 605             


Pro Arg Gln Ser Trp Leu Lys Tyr Asn Asp Ile Ser Val Thr Glu Ser 
    610                 615                 620                 


Ser Trp Glu Glu Val Glu Arg Asp Ser Tyr Gly Gly Leu Arg Asn Val 
625                 630                 635                 640 


Ser Ala Tyr Cys Leu Met Tyr Ile Asn Asp Lys Leu Pro Tyr Phe Asn 
                645                 650                 655     


Ala Glu Ala Ala Pro Thr Glu Ser Asp Gln Met Ser Glu Val Glu Ala 
            660                 665                 670         


Leu Ser Val Glu Leu Lys His Tyr Ile Gln Glu Asp Asn Trp Arg Phe 
        675                 680                 685             


Glu Gln Glu Val Glu Glu Trp Glu Glu Glu Gln Ser Cys Lys Ile Pro 
    690                 695                 700                 


Gln Met Glu Ser Ser Thr Asn Ser Ser Ser Gln Asp Tyr Ser Thr Ser 
705                 710                 715                 720 


Gln Glu Pro Ser Val Ala Ser Ser His Gly Val Arg Cys Leu Ser Ser 
                725                 730                 735     


Glu His Ala Val Ile Val Lys Glu Gln Thr Ala Gln Ala Ile Ala Asn 
            740                 745                 750         


Thr Ala Arg Ala Tyr Glu Lys Ser Gly Val Glu Ala Ala Leu Ser Glu 
        755                 760                 765             


Val Met Leu Ser Pro Ala Met Gln Gly Val Ile Leu Ala Ile Ala Lys 
    770                 775                 780                 


Ala Arg Gln Thr Phe Asp Arg Asp Gly Ser Glu Ala Gly Leu Ile Lys 
785                 790                 795                 800 


Ala Phe His Glu Glu Tyr Ser Arg Leu Tyr Gln Leu Ala Lys Glu Thr 
                805                 810                 815     


Pro Thr Ser His Ser Asp Pro Arg Leu Gln His Val Leu Val Tyr Phe 
            820                 825                 830         


Phe Gln Asn Glu Ala Pro Lys Arg Val Val Glu Arg Thr Leu Leu Glu 
        835                 840                 845             


Gln Phe Ala Asp Lys Asn Leu Ser Tyr Asp Glu Arg Ser Ile Ser Ile 
    850                 855                 860                 


Met Lys Val Ala Gln Ala Lys Leu Lys Glu Ile Gly Pro Asp Asp Met 
865                 870                 875                 880 


Asn Met Glu Glu Tyr Lys Lys Trp His Glu Asp Tyr Ser Leu Phe Arg 
                885                 890                 895     


Lys Val Ser Val Tyr Leu Leu Thr Gly Leu Glu Leu Tyr Gln Lys Gly 
            900                 905                 910         


Lys Tyr Gln Glu Ala Leu Ser Tyr Leu Val Tyr Ala Tyr Gln Ser Asn 
        915                 920                 925             


Ala Ala Leu Leu Met Lys Gly Pro Arg Arg Gly Val Lys Glu Ser Val 
    930                 935                 940                 


Ile Ala Leu Tyr Arg Arg Lys Cys Leu Leu Glu Leu Asn Ala Lys Ala 
945                 950                 955                 960 


Ala Ser Leu Phe Glu Thr Asn Asp Asp His Ser Val Thr Glu Gly Ile 
                965                 970                 975     


Asn Val Met Asn Glu Leu Ile Ile Pro Cys Ile His Leu Ile Ile Asn 
            980                 985                 990         


Asn Asp Ile Ser Lys Asp Asp Leu  Asp Ala Ile Glu Val  Met Arg Asn 
        995                 1000                 1005             


His Trp  Cys Ser Tyr Leu Gly  Gln Asp Ile Ala Glu  Asn Leu Gln 
    1010                 1015                 1020             


Leu Cys  Leu Gly Glu Phe Leu  Pro Arg Leu Leu Asp  Pro Ser Ala 
    1025                 1030                 1035             


Glu Ile  Ile Val Leu Lys Glu  Pro Pro Thr Ile Arg  Pro Asn Ser 
    1040                 1045                 1050             


Pro Tyr  Asp Leu Cys Ser Arg  Phe Ala Ala Val Met  Glu Ser Ile 
    1055                 1060                 1065             


Gln Gly  Val Ser Thr Val Thr  Val Lys 
    1070                 1075         


<210>  936
<211>  583
<212>  PRT
<213>  Homo sapiens

<400>  936

Met Thr Ala Glu Leu Gln Gln Asp Asp Ala Ala Gly Ala Ala Asp Gly 
1               5                   10                  15      


His Gly Ser Ser Cys Gln Met Leu Leu Asn Gln Leu Arg Glu Ile Thr 
            20                  25                  30          


Gly Ile Gln Asp Pro Ser Phe Leu His Glu Ala Leu Lys Ala Ser Asn 
        35                  40                  45              


Gly Asp Ile Thr Gln Ala Val Ser Leu Leu Thr Asp Glu Arg Val Lys 
    50                  55                  60                  


Glu Pro Ser Gln Asp Thr Val Ala Thr Glu Pro Ser Glu Val Glu Gly 
65                  70                  75                  80  


Ser Ala Ala Asn Lys Glu Val Leu Ala Lys Val Ile Asp Leu Thr His 
                85                  90                  95      


Asp Asn Lys Asp Asp Leu Gln Ala Ala Ile Ala Leu Ser Leu Leu Glu 
            100                 105                 110         


Ser Pro Lys Ile Gln Ala Asp Gly Arg Asp Leu Asn Arg Met His Glu 
        115                 120                 125             


Ala Thr Ser Ala Glu Thr Lys Arg Ser Lys Arg Lys Arg Cys Glu Val 
    130                 135                 140                 


Trp Gly Glu Asn Pro Asn Pro Asn Asp Trp Arg Arg Val Asp Gly Trp 
145                 150                 155                 160 


Pro Val Gly Leu Lys Asn Val Gly Asn Thr Cys Trp Phe Ser Ala Val 
                165                 170                 175     


Ile Gln Ser Leu Phe Gln Leu Pro Glu Phe Arg Arg Leu Val Leu Ser 
            180                 185                 190         


Tyr Ser Leu Pro Gln Asn Val Leu Glu Asn Cys Arg Ser His Thr Glu 
        195                 200                 205             


Lys Arg Asn Ile Met Phe Met Gln Glu Leu Gln Tyr Leu Phe Ala Leu 
    210                 215                 220                 


Met Met Gly Ser Asn Arg Lys Phe Val Asp Pro Ser Ala Ala Leu Asp 
225                 230                 235                 240 


Leu Leu Lys Gly Ala Phe Arg Ser Ser Glu Glu Gln Gln Gln Asp Val 
                245                 250                 255     


Ser Glu Phe Thr His Lys Leu Leu Asp Trp Leu Glu Asp Ala Phe Gln 
            260                 265                 270         


Leu Ala Val Asn Val Asn Ser Pro Arg Asn Lys Ser Glu Asn Pro Met 
        275                 280                 285             


Val Gln Leu Phe Tyr Gly Thr Phe Leu Thr Glu Gly Val Arg Glu Gly 
    290                 295                 300                 


Lys Pro Phe Cys Asn Asn Glu Thr Phe Gly Gln Tyr Pro Leu Gln Val 
305                 310                 315                 320 


Asn Gly Tyr Arg Asn Leu Asp Glu Cys Leu Glu Gly Ala Met Val Glu 
                325                 330                 335     


Gly Asp Val Glu Leu Leu Pro Ser Asp His Ser Val Lys Tyr Gly Gln 
            340                 345                 350         


Glu Arg Trp Phe Thr Lys Leu Pro Pro Val Leu Thr Phe Glu Leu Ser 
        355                 360                 365             


Arg Phe Glu Phe Asn Gln Ser Leu Gly Gln Pro Glu Lys Ile His Asn 
    370                 375                 380                 


Lys Leu Glu Phe Pro Gln Ile Ile Tyr Met Asp Arg Tyr Met Tyr Arg 
385                 390                 395                 400 


Ser Lys Glu Leu Ile Arg Asn Lys Arg Glu Cys Ile Arg Lys Leu Lys 
                405                 410                 415     


Glu Glu Ile Lys Ile Leu Gln Gln Lys Leu Glu Arg Tyr Val Lys Tyr 
            420                 425                 430         


Gly Ser Gly Pro Ala Arg Phe Pro Leu Pro Asp Met Leu Lys Tyr Val 
        435                 440                 445             


Ile Glu Phe Ala Ser Thr Lys Pro Ala Ser Glu Ser Cys Pro Pro Glu 
    450                 455                 460                 


Ser Asp Thr His Met Thr Leu Pro Leu Ser Ser Val His Cys Ser Val 
465                 470                 475                 480 


Ser Asp Gln Thr Ser Lys Glu Ser Thr Ser Thr Glu Ser Ser Ser Gln 
                485                 490                 495     


Asp Val Glu Ser Thr Phe Ser Ser Pro Glu Asp Ser Leu Pro Lys Ser 
            500                 505                 510         


Lys Pro Leu Thr Ser Ser Arg Ser Ser Met Glu Met Pro Ser Gln Pro 
        515                 520                 525             


Ala Pro Arg Thr Val Thr Asp Glu Glu Ile Asn Phe Val Lys Thr Cys 
    530                 535                 540                 


Leu Gln Arg Trp Arg Ser Glu Ile Glu Gln Asp Ile Gln Asp Leu Lys 
545                 550                 555                 560 


Thr Cys Ile Ala Ser Thr Thr Gln Thr Ile Glu Gln Met Tyr Cys Asp 
                565                 570                 575     


Pro Leu Leu Arg Gln Val Glu 
            580             


<210>  937
<211>  1477
<212>  DNA
<213>  Homo sapiens

<400>  937
agctgctgga gctgcagccc gaccgcgagc gtgccaagcg gcttcagcag ctagcggagc       60

ggtggcggcg gcccccctca ggacaccacc agattcccct cttcccgcgg cctcgccatg      120

gcgacccacg gacagacttg cgcgcgtcca atgtgtattc ctccatcata tgctgacctt      180

ggcaaagctg ccagagatat tttcaacaaa ggatttggtt ttgggttggt gaaactggat      240

gtgaaaacaa agtcttgcag tggcgtggaa ttttcaacgt ccggttcatc taatacagac      300

actggtaaag ttactgggac cttggagacc aaatacaagt ggtgtgagta tggtctgact      360

ttcacagaaa agtggaacac tgataacact ctgggaacag aaatcgcaat tgaagaccag      420

atttgtcaag gtttgaaact gacatttgat actaccttct caccaaacac aggaaagaaa      480

agtggtaaaa tcaagtcttc ttacaagagg gagtgtataa accttggttg tgatgttgac      540

tttgattttg ctggacctgc aatccatggt tcagctgtct ttggttatga gggctggctt      600

gctggctacc agatgacctt tgacagtgcc aaatcaaagc tgacaaggaa taactttgca      660

gtgggctaca ggactgggga cttccagcta cacactaatg tcaatgatgg gacagaattt      720

ggaggatcaa tttatcagaa agtttgtgaa gatcttgaca cttcagtaaa ccttgcttgg      780

acatcaggta ccaactgcac tcgttttggc attgcagcta aatatcagtt ggatcccact      840

gcttccattt ctgcaaaagt caacaactct agcttaattg gagtaggcta tactcagact      900

ctgaggcctg gtgtgaagct tacactctct gctctggtag atgggaagag cattaatgct      960

ggaggccaca aggttgggct cgccctggag ttggaggctt aatccagctg aaagaaacct     1020

ttgggaatgg atatcagaag atttggcctt aatatatttc cattgtgacc agcagcaggc     1080

ttttttcccc caagaagatg atcaaaacaa aggatgatct caacaagagc tgtattttaa     1140

gtatttagac agttctttgt tagctggttt ctagttggtt atctagttac caatgctgca     1200

gtcctgcagt cacctataca ttatttaaat gtatttaact gttaaatgcg ctacccacca     1260

ataatgaaat agacctttat gaaaactgtg caattgtgtg catgtttgtt tttatgttcc     1320

tttagaaaac attgactgtt accattgaat gagatggatc agtggatatt aagatgaggt     1380

tacaaatttt gttaagttca gccattatta cttttggtat cccagaacat gacaaattat     1440

gaataaaaca agtatacata aaaaaaaaaa aaaaaaa                              1477


<210>  938
<211>  294
<212>  PRT
<213>  Homo sapiens

<400>  938

Met Ala Thr His Gly Gln Thr Cys Ala Arg Pro Met Cys Ile Pro Pro 
1               5                   10                  15      


Ser Tyr Ala Asp Leu Gly Lys Ala Ala Arg Asp Ile Phe Asn Lys Gly 
            20                  25                  30          


Phe Gly Phe Gly Leu Val Lys Leu Asp Val Lys Thr Lys Ser Cys Ser 
        35                  40                  45              


Gly Val Glu Phe Ser Thr Ser Gly Ser Ser Asn Thr Asp Thr Gly Lys 
    50                  55                  60                  


Val Thr Gly Thr Leu Glu Thr Lys Tyr Lys Trp Cys Glu Tyr Gly Leu 
65                  70                  75                  80  


Thr Phe Thr Glu Lys Trp Asn Thr Asp Asn Thr Leu Gly Thr Glu Ile 
                85                  90                  95      


Ala Ile Glu Asp Gln Ile Cys Gln Gly Leu Lys Leu Thr Phe Asp Thr 
            100                 105                 110         


Thr Phe Ser Pro Asn Thr Gly Lys Lys Ser Gly Lys Ile Lys Ser Ser 
        115                 120                 125             


Tyr Lys Arg Glu Cys Ile Asn Leu Gly Cys Asp Val Asp Phe Asp Phe 
    130                 135                 140                 


Ala Gly Pro Ala Ile His Gly Ser Ala Val Phe Gly Tyr Glu Gly Trp 
145                 150                 155                 160 


Leu Ala Gly Tyr Gln Met Thr Phe Asp Ser Ala Lys Ser Lys Leu Thr 
                165                 170                 175     


Arg Asn Asn Phe Ala Val Gly Tyr Arg Thr Gly Asp Phe Gln Leu His 
            180                 185                 190         


Thr Asn Val Asn Asp Gly Thr Glu Phe Gly Gly Ser Ile Tyr Gln Lys 
        195                 200                 205             


Val Cys Glu Asp Leu Asp Thr Ser Val Asn Leu Ala Trp Thr Ser Gly 
    210                 215                 220                 


Thr Asn Cys Thr Arg Phe Gly Ile Ala Ala Lys Tyr Gln Leu Asp Pro 
225                 230                 235                 240 


Thr Ala Ser Ile Ser Ala Lys Val Asn Asn Ser Ser Leu Ile Gly Val 
                245                 250                 255     


Gly Tyr Thr Gln Thr Leu Arg Pro Gly Val Lys Leu Thr Leu Ser Ala 
            260                 265                 270         


Leu Val Asp Gly Lys Ser Ile Asn Ala Gly Gly His Lys Val Gly Leu 
        275                 280                 285             


Ala Leu Glu Leu Glu Ala 
    290                 


<210>  939
<211>  283
<212>  PRT
<213>  Homo sapiens

<400>  939

Met Cys Ile Pro Pro Ser Tyr Ala Asp Leu Gly Lys Ala Ala Arg Asp 
1               5                   10                  15      


Ile Phe Asn Lys Gly Phe Gly Phe Gly Leu Val Lys Leu Asp Val Lys 
            20                  25                  30          


Thr Lys Ser Cys Ser Gly Val Glu Phe Ser Thr Ser Gly Ser Ser Asn 
        35                  40                  45              


Thr Asp Thr Gly Lys Val Thr Gly Thr Leu Glu Thr Lys Tyr Lys Trp 
    50                  55                  60                  


Cys Glu Tyr Gly Leu Thr Phe Thr Glu Lys Trp Asn Thr Asp Asn Thr 
65                  70                  75                  80  


Leu Gly Thr Glu Ile Ala Ile Glu Asp Gln Ile Cys Gln Gly Leu Lys 
                85                  90                  95      


Leu Thr Phe Asp Thr Thr Phe Ser Pro Asn Thr Gly Lys Lys Ser Gly 
            100                 105                 110         


Lys Ile Lys Ser Ser Tyr Lys Arg Glu Cys Ile Asn Leu Gly Cys Asp 
        115                 120                 125             


Val Asp Phe Asp Phe Ala Gly Pro Ala Ile His Gly Ser Ala Val Phe 
    130                 135                 140                 


Gly Tyr Glu Gly Trp Leu Ala Gly Tyr Gln Met Thr Phe Asp Ser Ala 
145                 150                 155                 160 


Lys Ser Lys Leu Thr Arg Asn Asn Phe Ala Val Gly Tyr Arg Thr Gly 
                165                 170                 175     


Asp Phe Gln Leu His Thr Asn Val Asn Asp Gly Thr Glu Phe Gly Gly 
            180                 185                 190         


Ser Ile Tyr Gln Lys Val Cys Glu Asp Leu Asp Thr Ser Val Asn Leu 
        195                 200                 205             


Ala Trp Thr Ser Gly Thr Asn Cys Thr Arg Phe Gly Ile Ala Ala Lys 
    210                 215                 220                 


Tyr Gln Leu Asp Pro Thr Ala Ser Ile Ser Ala Lys Val Asn Asn Ser 
225                 230                 235                 240 


Ser Leu Ile Gly Val Gly Tyr Thr Gln Thr Leu Arg Pro Gly Val Lys 
                245                 250                 255     


Leu Thr Leu Ser Ala Leu Val Asp Gly Lys Ser Ile Asn Ala Gly Gly 
            260                 265                 270         


His Lys Val Gly Leu Ala Leu Glu Leu Glu Ala 
        275                 280             


<210>  940
<211>  3977
<212>  DNA
<213>  Homo sapiens

<400>  940
ccacgcgtcc gggagtggcc gccgagttgg aggcggtggt ggcagcagta ggagtgtgta       60

gagtgcggga ttgggggcca ggccctgcgg agggcggggg aagttgtctt cttttttttc      120

cggaggggcc ggtaaacctg gtggctgaac ggcaagatga atttcctccg cggggtaatg      180

gggggtcaga gtgccggacc ccagcacaca gaagccgaga cgattcaaaa gctttgtgac      240

agagtagctt catctacttt attggatgat cgaagaaatg ctgttcgtgc tctcaaatca      300

ttatctaaga aataccgctt ggaagtgggt atacaagcta tggaacatct tattcatgtt      360

ttacaaacag atcgttcaga ttctgaaata ataggttatg ctttggacac actatataat      420

ataatatcta atgaagaaga agaagtagaa gaaaattcca caagacagag tgaagatttg      480

ggaagccaat ttacagaaat tttcattaag cagcaggaaa atgtcactct tctgttatct      540

ttattggagg agtttgattt ccatgtccgc tggcctggtg tgaagcttct tacttctctt      600

ttaaaacaac tagggcctca ggtgcaacaa attattttag tcagtcctat gggtgtttca      660

agattgatgg acttactagc ggattccagg gaagttatac gtaatgatgg cgtcttacta      720

ctgcaggcac taacaagaag caatggtgca atccagaaaa ttgttgcttt tgaaaatgct      780

ttcgagagac tactggacat tatttcagag gaggggaaca gtgatggagg tatagtagtt      840

gaagattgtt tgattttgct ccaaaactta ttaaaaaaca acaactccaa tcaaaatttt      900

tttaaagaag gctcatatat tcaacgtatg aaaccttggt ttgaagttgg agatgaaaat      960

tctggctggt ctgcacagaa agtgaccaat ctacatctaa tgctacagct tgttcgtgta     1020

ttggtatctc ccaccaaccc tcctggtgct accagtagct gccagaaggc tatgttccag     1080

tgtgggttat tgcagcagct ttgtactatc ctaatggcta ctggggttcc tgctgatatc     1140

ctgactgaga ccataaatac tgtatcagaa gttattcgag gctgccaagt aaaccaagac     1200

tactttgcat ctgtaaatgc accttcaaac ccaccaagac cggcaattgt agtacttctc     1260

atgtccatgg ttaatgaaag gcagccattt gttttgcgct gtgctgttct ctattgtttc     1320

cagtgtttct tgtataaaaa ccaaaaagga caaggagaaa tcgtgtcaac acttttacct     1380

tctaccattg atgcaacagg taattcagtt tcagctggcc agttattatg tggaggtttg     1440

ttttctactg attcactttc aaactggtgt gctgctgtgg cccttgccca tgcgttgcaa     1500

gaaaatgcca cccagaaaga acagttgctc agggttcaac ttgctacaag tattggcaac     1560

cctccagttt ctttacttca acagtgcacc aatattcttt cacagggaag caaaatacaa     1620

acaagagttg gattattaat gttgctttgt acctggctaa gcaattgtcc cattgcagta     1680

acgcattttc ttcacaattc agccaatgtt ccattcctta caggacaaat tgcagaaaat     1740

cttggagaag aagagcagtt ggtccaaggc ttatgtgccc ttttgttggg catttcgatt     1800

tatttcaatg ataactcact tgagagctac atgaaagaga agctaaaaca actgattgag     1860

aagaggattg gcaaagagaa tttcatagag aaactaggat ttattagcaa acatgagttg     1920

tattccagag catctcagaa accccagcca aactttccca gtccagaata catgatattt     1980

gatcatgagt ttacgaagct ggtaaaagaa cttgaaggtg ttataactaa ggctatttat     2040

aagtccagtg aagaagataa aaaagaagaa gaggtgaaaa aaacattaga acagcatgac     2100

aatattgtga ctcactacaa aaatatgatt cgagagcaag atctccaact tgaggaatta     2160

aggcagcagg tttctacatt aaaatgtcaa aatgaacagc tccagacggc agtcacacag     2220

caagtatcac agatccagca gcacaaagac cagtataatc ttcttaaaat acagctagga     2280

aaagacaatc agcatcaagg ttcttacagt gagggggctc agatgaatgg cattcagcca     2340

gaagaaattg gtagattgcg agaagagata gaagaattaa aacgtaatca ggaactttta     2400

caaagccagc tgactgaaaa ggactctatg attgaaaata tgaaatcttc ccaaacatct     2460

ggcacaaatg aacagtcttc agcaatagtt tcagctagag attctgaaca agttgcagaa     2520

ttaaaacagg aactggcaac tttaaagtct cagttaaact cacaatctgt ggagatcacc     2580

aaactacaga cagaaaagca ggaactgtta cagaaaacag aagcgtttgc aaaatcagtt     2640

gaggtacaag gagagaccga gactataata gccaccaaaa ctactgatgt agaaggaaga     2700

ctgtcagcat tattacaaga gaccaaagag ttaaagaatg aaattaaagc tctgtctgag     2760

gaaagaactg ccattaaaga gcagctggat tcatctaata gtaccattgc cattttacaa     2820

actgagaaag acaaactaga gttggaaatt acagattcta aaaaagaaca agatgatctc     2880

ttggtgctct tggccgatca agatcagaaa atactgtcat tgaagaataa actcaaggat     2940

cttggtcatc cagttgaaga agaggatgaa cttgaatctg gagaccaaga ggatgaggat     3000

gatgaaagtg aagatcctgg caaggatcta gatcatatct agttttcaaa tctctaggaa     3060

caatagagat tatatcataa ctctgaagat ggactctaaa ctttggttta cctccatgga     3120

aaataaagat ttagaaacca ggtggaaaac attcactatt aagactattg atatattttt     3180

gtaatgttgc cacccatgtt gaaaacctta aaactgaatt tatgtagaac acacatcttt     3240

tatttaaatc catctgaact gtcccaaaat gtaatttgca aagagcttca aacaccaaaa     3300

atataccatt ttaaggcatg tggtgacaat gctatttgcc ttagttcatt cgttgtttac     3360

tttgcaaaat ttgtgacttt taagtactaa cacatttgat tgaatgtgta ttgaattgga     3420

attattattt ctaaattcag catttgagtc cttagttgat gattttcttt taaagaaatt     3480

agtttattta aaagcaagat agcctgggtt gggagttagt gcatatcatc agccctccat     3540

ctaatgtgat tgctaagatg tgcaggatag gacagcttag aatgagtgcc ttgacaccta     3600

catatggctg cattccatac ctcagtgaag aagccgaagg atgctgacac acagtgatgt     3660

ggagggcatt ccggagaaac ttttgcaaca gtgtattaat gtgattggtt ttctttttgt     3720

tttaagctaa acatctaaaa caaatttcaa gttaacagtt catacaactc agatttagta     3780

ttattgttta tcataaaaca tattatgttc ctagttttaa aaagacccaa agtatgatta     3840

atataattta ttggcatttt tgctgaatag gtttaagtca gataatagat tttaaaaaag     3900

caaatgaggc aatgtgtcaa aatttaatgt ttcataataa aaatagatac gttgacttaa     3960

aaaaaaaaaa aaaaaaa                                                    3977


<210>  941
<211>  962
<212>  PRT
<213>  Homo sapiens

<400>  941

Met Asn Phe Leu Arg Gly Val Met Gly Gly Gln Ser Ala Gly Pro Gln 
1               5                   10                  15      


His Thr Glu Ala Glu Thr Ile Gln Lys Leu Cys Asp Arg Val Ala Ser 
            20                  25                  30          


Ser Thr Leu Leu Asp Asp Arg Arg Asn Ala Val Arg Ala Leu Lys Ser 
        35                  40                  45              


Leu Ser Lys Lys Tyr Arg Leu Glu Val Gly Ile Gln Ala Met Glu His 
    50                  55                  60                  


Leu Ile His Val Leu Gln Thr Asp Arg Ser Asp Ser Glu Ile Ile Gly 
65                  70                  75                  80  


Tyr Ala Leu Asp Thr Leu Tyr Asn Ile Ile Ser Asn Glu Glu Glu Glu 
                85                  90                  95      


Glu Val Glu Glu Asn Ser Thr Arg Gln Ser Glu Asp Leu Gly Ser Gln 
            100                 105                 110         


Phe Thr Glu Ile Phe Ile Lys Gln Gln Glu Asn Val Thr Leu Leu Leu 
        115                 120                 125             


Ser Leu Leu Glu Glu Phe Asp Phe His Val Arg Trp Pro Gly Val Lys 
    130                 135                 140                 


Leu Leu Thr Ser Leu Leu Lys Gln Leu Gly Pro Gln Val Gln Gln Ile 
145                 150                 155                 160 


Ile Leu Val Ser Pro Met Gly Val Ser Arg Leu Met Asp Leu Leu Ala 
                165                 170                 175     


Asp Ser Arg Glu Val Ile Arg Asn Asp Gly Val Leu Leu Leu Gln Ala 
            180                 185                 190         


Leu Thr Arg Ser Asn Gly Ala Ile Gln Lys Ile Val Ala Phe Glu Asn 
        195                 200                 205             


Ala Phe Glu Arg Leu Leu Asp Ile Ile Ser Glu Glu Gly Asn Ser Asp 
    210                 215                 220                 


Gly Gly Ile Val Val Glu Asp Cys Leu Ile Leu Leu Gln Asn Leu Leu 
225                 230                 235                 240 


Lys Asn Asn Asn Ser Asn Gln Asn Phe Phe Lys Glu Gly Ser Tyr Ile 
                245                 250                 255     


Gln Arg Met Lys Pro Trp Phe Glu Val Gly Asp Glu Asn Ser Gly Trp 
            260                 265                 270         


Ser Ala Gln Lys Val Thr Asn Leu His Leu Met Leu Gln Leu Val Arg 
        275                 280                 285             


Val Leu Val Ser Pro Thr Asn Pro Pro Gly Ala Thr Ser Ser Cys Gln 
    290                 295                 300                 


Lys Ala Met Phe Gln Cys Gly Leu Leu Gln Gln Leu Cys Thr Ile Leu 
305                 310                 315                 320 


Met Ala Thr Gly Val Pro Ala Asp Ile Leu Thr Glu Thr Ile Asn Thr 
                325                 330                 335     


Val Ser Glu Val Ile Arg Gly Cys Gln Val Asn Gln Asp Tyr Phe Ala 
            340                 345                 350         


Ser Val Asn Ala Pro Ser Asn Pro Pro Arg Pro Ala Ile Val Val Leu 
        355                 360                 365             


Leu Met Ser Met Val Asn Glu Arg Gln Pro Phe Val Leu Arg Cys Ala 
    370                 375                 380                 


Val Leu Tyr Cys Phe Gln Cys Phe Leu Tyr Lys Asn Gln Lys Gly Gln 
385                 390                 395                 400 


Gly Glu Ile Val Ser Thr Leu Leu Pro Ser Thr Ile Asp Ala Thr Gly 
                405                 410                 415     


Asn Ser Val Ser Ala Gly Gln Leu Leu Cys Gly Gly Leu Phe Ser Thr 
            420                 425                 430         


Asp Ser Leu Ser Asn Trp Cys Ala Ala Val Ala Leu Ala His Ala Leu 
        435                 440                 445             


Gln Glu Asn Ala Thr Gln Lys Glu Gln Leu Leu Arg Val Gln Leu Ala 
    450                 455                 460                 


Thr Ser Ile Gly Asn Pro Pro Val Ser Leu Leu Gln Gln Cys Thr Asn 
465                 470                 475                 480 


Ile Leu Ser Gln Gly Ser Lys Ile Gln Thr Arg Val Gly Leu Leu Met 
                485                 490                 495     


Leu Leu Cys Thr Trp Leu Ser Asn Cys Pro Ile Ala Val Thr His Phe 
            500                 505                 510         


Leu His Asn Ser Ala Asn Val Pro Phe Leu Thr Gly Gln Ile Ala Glu 
        515                 520                 525             


Asn Leu Gly Glu Glu Glu Gln Leu Val Gln Gly Leu Cys Ala Leu Leu 
    530                 535                 540                 


Leu Gly Ile Ser Ile Tyr Phe Asn Asp Asn Ser Leu Glu Ser Tyr Met 
545                 550                 555                 560 


Lys Glu Lys Leu Lys Gln Leu Ile Glu Lys Arg Ile Gly Lys Glu Asn 
                565                 570                 575     


Phe Ile Glu Lys Leu Gly Phe Ile Ser Lys His Glu Leu Tyr Ser Arg 
            580                 585                 590         


Ala Ser Gln Lys Pro Gln Pro Asn Phe Pro Ser Pro Glu Tyr Met Ile 
        595                 600                 605             


Phe Asp His Glu Phe Thr Lys Leu Val Lys Glu Leu Glu Gly Val Ile 
    610                 615                 620                 


Thr Lys Ala Ile Tyr Lys Ser Ser Glu Glu Asp Lys Lys Glu Glu Glu 
625                 630                 635                 640 


Val Lys Lys Thr Leu Glu Gln His Asp Asn Ile Val Thr His Tyr Lys 
                645                 650                 655     


Asn Met Ile Arg Glu Gln Asp Leu Gln Leu Glu Glu Leu Arg Gln Gln 
            660                 665                 670         


Val Ser Thr Leu Lys Cys Gln Asn Glu Gln Leu Gln Thr Ala Val Thr 
        675                 680                 685             


Gln Gln Val Ser Gln Ile Gln Gln His Lys Asp Gln Tyr Asn Leu Leu 
    690                 695                 700                 


Lys Ile Gln Leu Gly Lys Asp Asn Gln His Gln Gly Ser Tyr Ser Glu 
705                 710                 715                 720 


Gly Ala Gln Met Asn Gly Ile Gln Pro Glu Glu Ile Gly Arg Leu Arg 
                725                 730                 735     


Glu Glu Ile Glu Glu Leu Lys Arg Asn Gln Glu Leu Leu Gln Ser Gln 
            740                 745                 750         


Leu Thr Glu Lys Asp Ser Met Ile Glu Asn Met Lys Ser Ser Gln Thr 
        755                 760                 765             


Ser Gly Thr Asn Glu Gln Ser Ser Ala Ile Val Ser Ala Arg Asp Ser 
    770                 775                 780                 


Glu Gln Val Ala Glu Leu Lys Gln Glu Leu Ala Thr Leu Lys Ser Gln 
785                 790                 795                 800 


Leu Asn Ser Gln Ser Val Glu Ile Thr Lys Leu Gln Thr Glu Lys Gln 
                805                 810                 815     


Glu Leu Leu Gln Lys Thr Glu Ala Phe Ala Lys Ser Val Glu Val Gln 
            820                 825                 830         


Gly Glu Thr Glu Thr Ile Ile Ala Thr Lys Thr Thr Asp Val Glu Gly 
        835                 840                 845             


Arg Leu Ser Ala Leu Leu Gln Glu Thr Lys Glu Leu Lys Asn Glu Ile 
    850                 855                 860                 


Lys Ala Leu Ser Glu Glu Arg Thr Ala Ile Lys Glu Gln Leu Asp Ser 
865                 870                 875                 880 


Ser Asn Ser Thr Ile Ala Ile Leu Gln Thr Glu Lys Asp Lys Leu Glu 
                885                 890                 895     


Leu Glu Ile Thr Asp Ser Lys Lys Glu Gln Asp Asp Leu Leu Val Leu 
            900                 905                 910         


Leu Ala Asp Gln Asp Gln Lys Ile Leu Ser Leu Lys Asn Lys Leu Lys 
        915                 920                 925             


Asp Leu Gly His Pro Val Glu Glu Glu Asp Glu Leu Glu Ser Gly Asp 
    930                 935                 940                 


Gln Glu Asp Glu Asp Asp Glu Ser Glu Asp Pro Gly Lys Asp Leu Asp 
945                 950                 955                 960 


His Ile 
        


<210>  942
<211>  961
<212>  PRT
<213>  Homo sapiens

<400>  942

Met Asn Phe Leu Arg Gly Val Met Gly Gly Gln Ser Ala Gly Pro Gln 
1               5                   10                  15      


His Thr Glu Ala Glu Thr Ile Gln Lys Leu Cys Asp Arg Val Ala Ser 
            20                  25                  30          


Ser Thr Leu Leu Asp Asp Arg Arg Asn Ala Val Arg Ala Leu Lys Ser 
        35                  40                  45              


Leu Ser Lys Lys Tyr Arg Leu Glu Val Gly Ile Gln Ala Met Glu His 
    50                  55                  60                  


Leu Ile His Val Leu Gln Thr Asp Arg Ser Asp Ser Glu Ile Ile Gly 
65                  70                  75                  80  


Tyr Ala Leu Asp Thr Leu Tyr Asn Ile Ile Ser Asn Glu Glu Glu Glu 
                85                  90                  95      


Val Glu Glu Asn Ser Thr Arg Gln Ser Glu Asp Leu Gly Ser Gln Phe 
            100                 105                 110         


Thr Glu Ile Phe Ile Lys Gln Gln Glu Asn Val Thr Leu Leu Leu Ser 
        115                 120                 125             


Leu Leu Glu Glu Phe Asp Phe His Val Arg Trp Pro Gly Val Lys Leu 
    130                 135                 140                 


Leu Thr Ser Leu Leu Lys Gln Leu Gly Pro Gln Val Gln Gln Ile Ile 
145                 150                 155                 160 


Leu Val Ser Pro Met Gly Val Ser Arg Leu Met Asp Leu Leu Ala Asp 
                165                 170                 175     


Ser Arg Glu Val Ile Arg Asn Asp Gly Val Leu Leu Leu Gln Ala Leu 
            180                 185                 190         


Thr Arg Ser Asn Gly Ala Ile Gln Lys Ile Val Ala Phe Glu Asn Ala 
        195                 200                 205             


Phe Glu Arg Leu Leu Asp Ile Ile Ser Glu Glu Gly Asn Ser Asp Gly 
    210                 215                 220                 


Gly Ile Val Val Glu Asp Cys Leu Ile Leu Leu Gln Asn Leu Leu Lys 
225                 230                 235                 240 


Asn Asn Asn Ser Asn Gln Asn Phe Phe Lys Glu Gly Ser Tyr Ile Gln 
                245                 250                 255     


Arg Met Lys Pro Trp Phe Glu Val Gly Asp Glu Asn Ser Gly Trp Ser 
            260                 265                 270         


Ala Gln Lys Val Thr Asn Leu His Leu Met Leu Gln Leu Val Arg Val 
        275                 280                 285             


Leu Val Ser Pro Thr Asn Pro Pro Gly Ala Thr Ser Ser Cys Gln Lys 
    290                 295                 300                 


Ala Met Phe Gln Cys Gly Leu Leu Gln Gln Leu Cys Thr Ile Leu Met 
305                 310                 315                 320 


Ala Thr Gly Val Pro Ala Asp Ile Leu Thr Glu Thr Ile Asn Thr Val 
                325                 330                 335     


Ser Glu Val Ile Arg Gly Cys Gln Val Asn Gln Asp Tyr Phe Ala Ser 
            340                 345                 350         


Val Asn Ala Pro Ser Asn Pro Pro Arg Pro Ala Ile Val Val Leu Leu 
        355                 360                 365             


Met Ser Met Val Asn Glu Arg Gln Pro Phe Val Leu Arg Cys Ala Val 
    370                 375                 380                 


Leu Tyr Cys Phe Gln Cys Phe Leu Tyr Lys Asn Gln Lys Gly Gln Gly 
385                 390                 395                 400 


Glu Ile Val Ser Thr Leu Leu Pro Ser Thr Ile Asp Ala Thr Gly Asn 
                405                 410                 415     


Ser Val Ser Ala Gly Gln Leu Leu Cys Gly Gly Leu Phe Ser Thr Asp 
            420                 425                 430         


Ser Leu Ser Asn Trp Cys Ala Ala Val Ala Leu Ala His Ala Leu Gln 
        435                 440                 445             


Glu Asn Ala Thr Gln Lys Glu Gln Leu Leu Arg Val Gln Leu Ala Thr 
    450                 455                 460                 


Ser Ile Gly Asn Pro Pro Val Ser Leu Leu Gln Gln Cys Thr Asn Ile 
465                 470                 475                 480 


Leu Ser Gln Gly Ser Lys Ile Gln Thr Arg Val Gly Leu Leu Met Leu 
                485                 490                 495     


Leu Cys Thr Trp Leu Ser Asn Cys Pro Ile Ala Val Thr His Phe Leu 
            500                 505                 510         


His Asn Ser Ala Asn Val Pro Phe Leu Thr Gly Gln Ile Ala Glu Asn 
        515                 520                 525             


Leu Gly Glu Glu Glu Gln Leu Val Gln Gly Leu Cys Ala Leu Leu Leu 
    530                 535                 540                 


Gly Ile Ser Ile Tyr Phe Asn Asp Asn Ser Leu Glu Ser Tyr Met Lys 
545                 550                 555                 560 


Glu Lys Leu Lys Gln Leu Ile Glu Lys Arg Ile Gly Lys Glu Asn Phe 
                565                 570                 575     


Ile Glu Lys Leu Gly Phe Ile Ser Lys His Glu Leu Tyr Ser Arg Ala 
            580                 585                 590         


Ser Gln Lys Pro Gln Pro Asn Phe Pro Ser Pro Glu Tyr Met Ile Phe 
        595                 600                 605             


Asp His Glu Phe Thr Lys Leu Val Lys Glu Leu Glu Gly Val Ile Thr 
    610                 615                 620                 


Lys Ala Ile Tyr Lys Ser Ser Glu Glu Asp Lys Lys Glu Glu Glu Val 
625                 630                 635                 640 


Lys Lys Thr Leu Glu Gln His Asp Asn Ile Val Thr His Tyr Lys Asn 
                645                 650                 655     


Met Ile Arg Glu Gln Asp Leu Gln Leu Glu Glu Leu Arg Gln Gln Val 
            660                 665                 670         


Ser Thr Leu Lys Cys Gln Asn Glu Gln Leu Gln Thr Ala Val Thr Gln 
        675                 680                 685             


Gln Val Ser Gln Ile Gln Gln His Lys Asp Gln Tyr Asn Leu Leu Lys 
    690                 695                 700                 


Ile Gln Leu Gly Lys Asp Asn Gln His Gln Gly Ser Tyr Ser Glu Gly 
705                 710                 715                 720 


Ala Gln Met Asn Gly Ile Gln Pro Glu Glu Ile Gly Arg Leu Arg Glu 
                725                 730                 735     


Glu Ile Glu Glu Leu Lys Arg Asn Gln Glu Leu Leu Gln Ser Gln Leu 
            740                 745                 750         


Thr Glu Lys Asp Ser Met Ile Glu Asn Met Lys Ser Ser Gln Thr Ser 
        755                 760                 765             


Gly Thr Asn Glu Gln Ser Ser Ala Ile Val Ser Ala Arg Asp Ser Glu 
    770                 775                 780                 


Gln Val Ala Glu Leu Lys Gln Glu Leu Ala Thr Leu Lys Ser Gln Leu 
785                 790                 795                 800 


Asn Ser Gln Ser Val Glu Ile Thr Lys Leu Gln Thr Glu Lys Gln Glu 
                805                 810                 815     


Leu Leu Gln Lys Thr Glu Ala Phe Ala Lys Ser Val Glu Val Gln Gly 
            820                 825                 830         


Glu Thr Glu Thr Ile Ile Ala Thr Lys Thr Thr Asp Val Glu Gly Arg 
        835                 840                 845             


Leu Ser Ala Leu Leu Gln Glu Thr Lys Glu Leu Lys Asn Glu Ile Lys 
    850                 855                 860                 


Ala Leu Ser Glu Glu Arg Thr Ala Ile Lys Glu Gln Leu Asp Ser Ser 
865                 870                 875                 880 


Asn Ser Thr Ile Ala Ile Leu Gln Thr Glu Lys Asp Lys Leu Glu Leu 
                885                 890                 895     


Glu Ile Thr Asp Ser Lys Lys Glu Gln Asp Asp Leu Leu Val Leu Leu 
            900                 905                 910         


Ala Asp Gln Asp Gln Lys Ile Leu Ser Leu Lys Asn Lys Leu Lys Asp 
        915                 920                 925             


Leu Gly His Pro Val Glu Glu Glu Asp Glu Leu Glu Ser Gly Asp Gln 
    930                 935                 940                 


Glu Asp Glu Asp Asp Glu Ser Glu Asp Pro Gly Lys Asp Leu Asp His 
945                 950                 955                 960 


Ile 
    


<210>  943
<211>  566
<212>  DNA
<213>  Homo sapiens

<400>  943
caccatgcct gcttgtcgcc taggcccgct agccgccgcc ctcctcctca gcctgctgct       60

gttcggcttc accctagtct caggcacagg agcagagaag actggcgtgt gccccgagct      120

ccaggctgac cagaactgca cgcaagagtg cgtctcggac agcgaatgcg ccgacaacct      180

caagtgctgc agcgcgggct gtgccacctt ctgctctctg cccaatgata aggagggttc      240

ctgcccccag gtgaacatta actttcccca gctcggcctc tgtcgggacc agtgccaggt      300

ggacagccag tgtcctggcc agatgaaatg ctgccgcaat ggctgtggga aggtgtcctg      360

tgtcactccc aatttctgag ctccagccac caccaggctg agcagtgagg agagaaagtt      420

tctgcctggc cctgcatctg gttccagccc acctgccctc ccctttttcg ggactctgta      480

ttccctcttg ggctgaccac agcttctccc tttcccaacc aataaagtaa ccactttcag      540

caaaaaaaaa aaaaaaaaaa aaaaaa                                           566


<210>  944
<211>  124
<212>  PRT
<213>  Homo sapiens

<400>  944

Met Pro Ala Cys Arg Leu Gly Pro Leu Ala Ala Ala Leu Leu Leu Ser 
1               5                   10                  15      


Leu Leu Leu Phe Gly Phe Thr Leu Val Ser Gly Thr Gly Ala Glu Lys 
            20                  25                  30          


Thr Gly Val Cys Pro Glu Leu Gln Ala Asp Gln Asn Cys Thr Gln Glu 
        35                  40                  45              


Cys Val Ser Asp Ser Glu Cys Ala Asp Asn Leu Lys Cys Cys Ser Ala 
    50                  55                  60                  


Gly Cys Ala Thr Phe Cys Ser Leu Pro Asn Asp Lys Glu Gly Ser Cys 
65                  70                  75                  80  


Pro Gln Val Asn Ile Asn Phe Pro Gln Leu Gly Leu Cys Arg Asp Gln 
                85                  90                  95      


Cys Gln Val Asp Ser Gln Cys Pro Gly Gln Met Lys Cys Cys Arg Asn 
            100                 105                 110         


Gly Cys Gly Lys Val Ser Cys Val Thr Pro Asn Phe 
        115                 120                 


<210>  945
<211>  124
<212>  PRT
<213>  Homo sapiens

<400>  945

Met Pro Ala Cys Arg Leu Gly Pro Leu Ala Ala Ala Leu Leu Leu Ser 
1               5                   10                  15      


Leu Leu Leu Phe Gly Phe Thr Leu Val Ser Gly Thr Gly Ala Glu Lys 
            20                  25                  30          


Thr Gly Val Cys Pro Glu Leu Gln Ala Asp Gln Asn Cys Thr Gln Glu 
        35                  40                  45              


Cys Val Ser Asp Ser Glu Cys Ala Asp Asn Leu Lys Cys Cys Ser Ala 
    50                  55                  60                  


Gly Cys Ala Thr Phe Cys Ser Leu Pro Asn Asp Lys Glu Gly Ser Cys 
65                  70                  75                  80  


Pro Gln Val Asn Ile Asn Phe Pro Gln Leu Gly Leu Cys Arg Asp Gln 
                85                  90                  95      


Cys Gln Val Asp Ser Gln Cys Pro Gly Gln Met Lys Cys Cys Arg Asn 
            100                 105                 110         


Gly Cys Gly Lys Val Ser Cys Val Thr Pro Asn Phe 
        115                 120                 


<210>  946
<211>  1468
<212>  DNA
<213>  Homo sapiens

<400>  946
tgcatgctcc agggacggca cccttgtctg gggcaggtgc ttgtgggggc tgaggctgcc       60

ttgctcccca cacccctgcc cctgacctgg gagtgtaccg ctgtgtgtgc ccagcacgca      120

taacgtcccc agacaaaccg cggccgatgc ccatggacac gagcgtgtat gagagcccct      180

acagcgaccc agaggagctc aaggacaaga agctcttcct gaagcgcgat aacctcctca      240

tagctgacat tgaacttggc tgcggcaact ttggctcagt gcgccagggc gtgtaccgca      300

tgcgcaagaa gcagatcgac gtggccatca aggtgctgaa gcagggcacg gagaaggcag      360

acacggaaga gatgatgcgc gaggcgcaga tcatgcacca gctggacaac ccctacatcg      420

tgcggctcat tggcgtctgc caggccgagg ccctcatgct ggtcatggag atggctgggg      480

gcgggccgct gcacaagttc ctggtcggca agagggagga gatccctgtg agcaatgtgg      540

ccgagctgct gcaccaggtg tccatgggga tgaagtacct ggaggagaag aactttgtgc      600

accgtgacct ggcggcccgc aacgtcctgc tggttaaccg gcactacgcc aagatcagcg      660

actttggcct ctccaaagca ctgggtgccg acgacagcta ctacactgcc cgctcagcag      720

ggaagtggcc gctcaagtgg tacgcacccg aatgcatcaa cttccgcaag ttctccagcc      780

gcagcgatgt ctggagctat ggggtcacca tgtgggaggc cttgtcctac ggccagaagc      840

cctacaagaa gatgaaaggg ccggaggtca tggccttcat cgagcagggc aagcggatgg      900

agtgcccacc agagtgtcca cccgaactgt acgcactcat gagtgactgc tggatctaca      960

agtgggagga tcgccccgac ttcctgaccg tggagcagcg catgcgagcc tgttactaca     1020

gcctggccag caaggtggaa gggcccccag gcagcacaca gaaggctgag gctgcctgtg     1080

cctgagctcc cgctgcccag gggagccctc cacgccggct cttccccacc ctcagcccca     1140

ccccaggtcc tgcagtctgg ctgagccctg cttggttgtc tccacacaca gctgggctgt     1200

ggtagggggt gtctcaggcc acaccggcct tgcattgcct gcctggcccc ctgtcctctc     1260

tggctgggga gcagggaggt ccgggagggt gcggctgtgc agcctgtcct gggctggtgg     1320

ctcccggagg gccctgagct gagggcattg cttacacgga tgccttcccc tgggccctga     1380

cattggagcc tgggcatcct caggtggtca ggcgtagatc accagaataa acccagcttc     1440

cctcttgaaa aaaaaaaaaa aaaaaaaa                                        1468


<210>  947
<211>  619
<212>  PRT
<213>  Homo sapiens

<400>  947

Met Pro Asp Pro Ala Ala His Leu Pro Phe Phe Tyr Gly Ser Ile Ser 
1               5                   10                  15      


Arg Ala Glu Ala Glu Glu His Leu Lys Leu Ala Gly Met Ala Asp Gly 
            20                  25                  30          


Leu Phe Leu Leu Arg Gln Cys Leu Arg Ser Leu Gly Gly Tyr Val Leu 
        35                  40                  45              


Ser Leu Val His Asp Val Arg Phe His His Phe Pro Ile Glu Arg Gln 
    50                  55                  60                  


Leu Asn Gly Thr Tyr Ala Ile Ala Gly Gly Lys Ala His Cys Gly Pro 
65                  70                  75                  80  


Ala Glu Leu Cys Glu Phe Tyr Ser Arg Asp Pro Asp Gly Leu Pro Cys 
                85                  90                  95      


Asn Leu Arg Lys Pro Cys Asn Arg Pro Ser Gly Leu Glu Pro Gln Pro 
            100                 105                 110         


Gly Val Phe Asp Cys Leu Arg Asp Ala Met Val Arg Asp Tyr Val Arg 
        115                 120                 125             


Gln Thr Trp Lys Leu Glu Gly Glu Ala Leu Glu Gln Ala Ile Ile Ser 
    130                 135                 140                 


Gln Ala Pro Gln Val Glu Lys Leu Ile Ala Thr Thr Ala His Glu Arg 
145                 150                 155                 160 


Met Pro Trp Tyr His Ser Ser Leu Thr Arg Glu Glu Ala Glu Arg Lys 
                165                 170                 175     


Leu Tyr Ser Gly Ala Gln Thr Asp Gly Lys Phe Leu Leu Arg Pro Arg 
            180                 185                 190         


Lys Glu Gln Gly Thr Tyr Ala Leu Ser Leu Ile Tyr Gly Lys Thr Val 
        195                 200                 205             


Tyr His Tyr Leu Ile Ser Gln Asp Lys Ala Gly Lys Tyr Cys Ile Pro 
    210                 215                 220                 


Glu Gly Thr Lys Phe Asp Thr Leu Trp Gln Leu Val Glu Tyr Leu Lys 
225                 230                 235                 240 


Leu Lys Ala Asp Gly Leu Ile Tyr Cys Leu Lys Glu Ala Cys Pro Asn 
                245                 250                 255     


Ser Ser Ala Ser Asn Ala Ser Gly Ala Ala Ala Pro Thr Leu Pro Ala 
            260                 265                 270         


His Pro Ser Thr Leu Thr His Pro Gln Arg Arg Ile Asp Thr Leu Asn 
        275                 280                 285             


Ser Asp Gly Tyr Thr Pro Glu Pro Ala Arg Ile Thr Ser Pro Asp Lys 
    290                 295                 300                 


Pro Arg Pro Met Pro Met Asp Thr Ser Val Tyr Glu Ser Pro Tyr Ser 
305                 310                 315                 320 


Asp Pro Glu Glu Leu Lys Asp Lys Lys Leu Phe Leu Lys Arg Asp Asn 
                325                 330                 335     


Leu Leu Ile Ala Asp Ile Glu Leu Gly Cys Gly Asn Phe Gly Ser Val 
            340                 345                 350         


Arg Gln Gly Val Tyr Arg Met Arg Lys Lys Gln Ile Asp Val Ala Ile 
        355                 360                 365             


Lys Val Leu Lys Gln Gly Thr Glu Lys Ala Asp Thr Glu Glu Met Met 
    370                 375                 380                 


Arg Glu Ala Gln Ile Met His Gln Leu Asp Asn Pro Tyr Ile Val Arg 
385                 390                 395                 400 


Leu Ile Gly Val Cys Gln Ala Glu Ala Leu Met Leu Val Met Glu Met 
                405                 410                 415     


Ala Gly Gly Gly Pro Leu His Lys Phe Leu Val Gly Lys Arg Glu Glu 
            420                 425                 430         


Ile Pro Val Ser Asn Val Ala Glu Leu Leu His Gln Val Ser Met Gly 
        435                 440                 445             


Met Lys Tyr Leu Glu Glu Lys Asn Phe Val His Arg Asp Leu Ala Ala 
    450                 455                 460                 


Arg Asn Val Leu Leu Val Asn Arg His Tyr Ala Lys Ile Ser Asp Phe 
465                 470                 475                 480 


Gly Leu Ser Lys Ala Leu Gly Ala Asp Asp Ser Tyr Tyr Thr Ala Arg 
                485                 490                 495     


Ser Ala Gly Lys Trp Pro Leu Lys Trp Tyr Ala Pro Glu Cys Ile Asn 
            500                 505                 510         


Phe Arg Lys Phe Ser Ser Arg Ser Asp Val Trp Ser Tyr Gly Val Thr 
        515                 520                 525             


Met Trp Glu Ala Leu Ser Tyr Gly Gln Lys Pro Tyr Lys Lys Met Lys 
    530                 535                 540                 


Gly Pro Glu Val Met Ala Phe Ile Glu Gln Gly Lys Arg Met Glu Cys 
545                 550                 555                 560 


Pro Pro Glu Cys Pro Pro Glu Leu Tyr Ala Leu Met Ser Asp Cys Trp 
                565                 570                 575     


Ile Tyr Lys Trp Glu Asp Arg Pro Asp Phe Leu Thr Val Glu Gln Arg 
            580                 585                 590         


Met Arg Ala Cys Tyr Tyr Ser Leu Ala Ser Lys Val Glu Gly Pro Pro 
        595                 600                 605             


Gly Ser Thr Gln Lys Ala Glu Ala Ala Cys Ala 
    610                 615                 


<210>  948
<211>  312
<212>  PRT
<213>  Homo sapiens

<400>  948

Met Pro Met Asp Thr Ser Val Tyr Glu Ser Pro Tyr Ser Asp Pro Glu 
1               5                   10                  15      


Glu Leu Lys Asp Lys Lys Leu Phe Leu Lys Arg Asp Asn Leu Leu Ile 
            20                  25                  30          


Ala Asp Ile Glu Leu Gly Cys Gly Asn Phe Gly Ser Val Arg Gln Gly 
        35                  40                  45              


Val Tyr Arg Met Arg Lys Lys Gln Ile Asp Val Ala Ile Lys Val Leu 
    50                  55                  60                  


Lys Gln Gly Thr Glu Lys Ala Asp Thr Glu Glu Met Met Arg Glu Ala 
65                  70                  75                  80  


Gln Ile Met His Gln Leu Asp Asn Pro Tyr Ile Val Arg Leu Ile Gly 
                85                  90                  95      


Val Cys Gln Ala Glu Ala Leu Met Leu Val Met Glu Met Ala Gly Gly 
            100                 105                 110         


Gly Pro Leu His Lys Phe Leu Val Gly Lys Arg Glu Glu Ile Pro Val 
        115                 120                 125             


Ser Asn Val Ala Glu Leu Leu His Gln Val Ser Met Gly Met Lys Tyr 
    130                 135                 140                 


Leu Glu Glu Lys Asn Phe Val His Arg Asp Leu Ala Ala Arg Asn Val 
145                 150                 155                 160 


Leu Leu Val Asn Arg His Tyr Ala Lys Ile Ser Asp Phe Gly Leu Ser 
                165                 170                 175     


Lys Ala Leu Gly Ala Asp Asp Ser Tyr Tyr Thr Ala Arg Ser Ala Gly 
            180                 185                 190         


Lys Trp Pro Leu Lys Trp Tyr Ala Pro Glu Cys Ile Asn Phe Arg Lys 
        195                 200                 205             


Phe Ser Ser Arg Ser Asp Val Trp Ser Tyr Gly Val Thr Met Trp Glu 
    210                 215                 220                 


Ala Leu Ser Tyr Gly Gln Lys Pro Tyr Lys Lys Met Lys Gly Pro Glu 
225                 230                 235                 240 


Val Met Ala Phe Ile Glu Gln Gly Lys Arg Met Glu Cys Pro Pro Glu 
                245                 250                 255     


Cys Pro Pro Glu Leu Tyr Ala Leu Met Ser Asp Cys Trp Ile Tyr Lys 
            260                 265                 270         


Trp Glu Asp Arg Pro Asp Phe Leu Thr Val Glu Gln Arg Met Arg Ala 
        275                 280                 285             


Cys Tyr Tyr Ser Leu Ala Ser Lys Val Glu Gly Pro Pro Gly Ser Thr 
    290                 295                 300                 


Gln Lys Ala Glu Ala Ala Cys Ala 
305                 310         


<210>  949
<211>  1505
<212>  DNA
<213>  Homo sapiens

<400>  949
aagggacgcg ttgacattca ctggctagtc caccgctctc agtcggagac cacattgcct       60

cgaaggcgat tgtgaagcgg ggctctgagg ggcttgatgc cccccacccc tcacacggag      120

accttgaaag aggtgtccaa ctatccatta ccaagaagaa atctattcgt ttgagcctga      180

gacactcttt gaggtaaaaa attagaatga aagaaccttt ggatggtgaa tgtggcaaag      240

cagtggtacc acagcaggag cttctggaca aaattaaaga agaaccagac aatgctcaag      300

agtatggatg tgtccaacag ccaaaaactc aagaaagtaa attgaaaatt ggtggtgtgt      360

cttcagttaa tgagagacct attgcccagc agttgaaccc aggctttcag ctttcttttg      420

catcatctgg cccaagtgtg ttgcttcctt cagttccagc tgttgctatt aaggtttttt      480

gttctggttg taaaaaaatg ctttataagg gccaaactgc atatcataag acaggatcta      540

ctcagctctt ctgctccaca cgatgcatca ccagacattc ttcacctgcc tgcctgccac      600

ctcctcccaa gaaaacctgc acaaactgct cgaagtataa aattcttaac atcccttttt      660

actttacctt tttttagtgt gtatattgtt tagttcaaac atactgttga tactttaaat      720

ctcttcagca tgtatctgta gaaataactt tttagttaat ggaagaattc accaatttta      780

aagttttgca acattaaata agtgacttgg tgttagaata ttgcctaaac cagttttcta      840

tcactttaaa ttttactatg gaaagaaata acaaatgaca tgtgggaatt gcaggactat      900

cctgtaattg tagacaccca ccatttaaat ttatttaaca gttatcttga aagctattgg      960

gtatagcata aaataatatc actcttttaa tagtatacaa aagctattta attctttaaa     1020

aagtaaaaac tctacatggt cgcaaaaatg tgtttatttc taatgtcctt gtggggtcat     1080

tgttgtttta caataatgct tagatgcaga gagaggaaaa aacagcaaca aagtcacata     1140

aatctttccc tgacttagta catttgaagg atttggcata ttttgcctat ttctgtggta     1200

gtgtaatttg aggaatacag tgtgttgtta atagtcacta caggcaaaaa acagtaagag     1260

cttgctttta aattgtggct ctgtcattta tctctgtgac ttcgggctag atgtttaact     1320

ttctaagcct ccatttctca tcagtaaata atagttgctt cctaggactt taatgagaca     1380

gtgttagcaa atggcctagc acatagcaag tacttaaaaa atggaatcct gttattatta     1440

ataataaaaa ttatatcgtg cgattattta taaccaaaaa aaaaaaaaaa aaaaaaaaaa     1500

aaaaa                                                                 1505


<210>  950
<211>  1325
<212>  PRT
<213>  Homo sapiens

<400>  950

Met Lys Glu Pro Leu Asp Gly Glu Cys Gly Lys Ala Val Val Pro Gln 
1               5                   10                  15      


Gln Glu Leu Leu Asp Lys Ile Lys Glu Glu Pro Asp Asn Ala Gln Glu 
            20                  25                  30          


Tyr Gly Cys Val Gln Gln Pro Lys Thr Gln Glu Ser Lys Leu Lys Ile 
        35                  40                  45              


Gly Gly Val Ser Ser Val Asn Glu Arg Pro Ile Ala Gln Gln Leu Asn 
    50                  55                  60                  


Pro Gly Phe Gln Leu Ser Phe Ala Ser Ser Gly Pro Ser Val Leu Leu 
65                  70                  75                  80  


Pro Ser Val Pro Ala Val Ala Ile Lys Val Phe Cys Ser Gly Cys Lys 
                85                  90                  95      


Lys Met Leu Tyr Lys Gly Gln Thr Ala Tyr His Lys Thr Gly Ser Thr 
            100                 105                 110         


Gln Leu Phe Cys Ser Thr Arg Cys Ile Thr Arg His Ser Ser Pro Ala 
        115                 120                 125             


Cys Leu Pro Pro Pro Pro Lys Lys Thr Cys Thr Asn Cys Ser Lys Asp 
    130                 135                 140                 


Ile Leu Asn Pro Lys Asp Val Ile Thr Thr Arg Phe Glu Asn Ser Tyr 
145                 150                 155                 160 


Pro Ser Lys Asp Phe Cys Ser Gln Ser Cys Leu Ser Ser Tyr Glu Leu 
                165                 170                 175     


Lys Lys Lys Pro Val Val Thr Ile Tyr Thr Lys Ser Ile Ser Thr Lys 
            180                 185                 190         


Cys Ser Met Cys Gln Lys Asn Ala Asp Thr Arg Phe Glu Val Lys Tyr 
        195                 200                 205             


Gln Asn Val Val His Gly Leu Cys Ser Asp Ala Cys Phe Ser Lys Phe 
    210                 215                 220                 


His Ser Thr Asn Asn Leu Thr Met Asn Cys Cys Glu Asn Cys Gly Ser 
225                 230                 235                 240 


Tyr Cys Tyr Ser Ser Ser Gly Pro Cys Gln Ser Gln Lys Val Phe Ser 
                245                 250                 255     


Ser Thr Ser Val Thr Ala Tyr Lys Gln Asn Ser Ala Gln Ile Pro Pro 
            260                 265                 270         


Tyr Ala Leu Gly Lys Ser Leu Arg Pro Ser Ala Glu Met Ile Glu Thr 
        275                 280                 285             


Thr Asn Asp Ser Gly Lys Thr Glu Leu Phe Cys Ser Ile Asn Cys Leu 
    290                 295                 300                 


Ser Ala Tyr Arg Val Lys Thr Val Thr Ser Ser Gly Val Gln Val Ser 
305                 310                 315                 320 


Cys His Ser Cys Lys Thr Ser Ala Ile Pro Gln Tyr His Leu Ala Met 
                325                 330                 335     


Ser Asn Gly Thr Ile Tyr Ser Phe Cys Ser Ser Ser Cys Val Val Ala 
            340                 345                 350         


Phe Gln Asn Val Phe Ser Lys Pro Lys Gly Thr Asn Ser Ser Ala Val 
        355                 360                 365             


Pro Leu Ser Gln Gly Gln Val Val Val Ser Pro Pro Ser Ser Arg Ser 
    370                 375                 380                 


Ala Val Ser Ile Gly Gly Gly Asn Thr Ser Ala Val Ser Pro Ser Ser 
385                 390                 395                 400 


Ile Arg Gly Ser Ala Ala Ala Ser Leu Gln Pro Leu Ala Glu Gln Ser 
                405                 410                 415     


Gln Gln Val Ala Leu Thr His Thr Val Val Lys Leu Lys Cys Gln His 
            420                 425                 430         


Cys Asn His Leu Phe Ala Thr Lys Pro Glu Leu Leu Phe Tyr Lys Gly 
        435                 440                 445             


Lys Met Phe Leu Phe Cys Gly Lys Asn Cys Ser Asp Glu Tyr Lys Lys 
    450                 455                 460                 


Lys Asn Lys Val Val Ala Met Cys Asp Tyr Cys Lys Leu Gln Lys Ile 
465                 470                 475                 480 


Ile Lys Glu Thr Val Arg Phe Ser Gly Val Asp Lys Pro Phe Cys Ser 
                485                 490                 495     


Glu Val Cys Lys Phe Leu Ser Ala Arg Asp Phe Gly Glu Arg Trp Gly 
            500                 505                 510         


Asn Tyr Cys Lys Met Cys Ser Tyr Cys Ser Gln Thr Ser Pro Asn Leu 
        515                 520                 525             


Val Glu Asn Arg Leu Glu Gly Lys Leu Glu Glu Phe Cys Cys Glu Asp 
    530                 535                 540                 


Cys Met Ser Lys Phe Thr Val Leu Phe Tyr Gln Met Ala Lys Cys Asp 
545                 550                 555                 560 


Gly Cys Lys Arg Gln Gly Lys Leu Ser Glu Ser Ile Lys Trp Arg Gly 
                565                 570                 575     


Asn Ile Lys His Phe Cys Asn Leu Phe Cys Val Leu Glu Phe Cys His 
            580                 585                 590         


Gln Gln Ile Met Asn Asp Cys Leu Pro Gln Asn Lys Val Asn Ile Ser 
        595                 600                 605             


Lys Ala Lys Thr Ala Val Thr Glu Leu Pro Ser Ala Arg Thr Asp Thr 
    610                 615                 620                 


Thr Pro Val Ile Thr Ser Val Met Ser Leu Ala Lys Ile Pro Ala Thr 
625                 630                 635                 640 


Leu Ser Thr Gly Asn Thr Asn Ser Val Leu Lys Gly Ala Val Thr Lys 
                645                 650                 655     


Glu Ala Ala Lys Ile Ile Gln Asp Glu Ser Thr Gln Glu Asp Ala Met 
            660                 665                 670         


Lys Phe Pro Ser Ser Gln Ser Ser Gln Pro Ser Arg Leu Leu Lys Asn 
        675                 680                 685             


Lys Gly Ile Ser Cys Lys Pro Val Thr Gln Thr Lys Ala Thr Ser Cys 
    690                 695                 700                 


Lys Pro His Thr Gln His Lys Glu Cys Gln Thr Asp Leu Pro Met Pro 
705                 710                 715                 720 


Asn Glu Lys Asn Asp Ala Glu Leu Asp Ser Pro Pro Ser Lys Lys Lys 
                725                 730                 735     


Arg Leu Gly Phe Phe Gln Thr Tyr Asp Thr Glu Tyr Leu Lys Val Gly 
            740                 745                 750         


Phe Ile Ile Cys Pro Gly Ser Lys Glu Ser Ser Pro Arg Pro Gln Cys 
        755                 760                 765             


Val Ile Cys Gly Glu Ile Leu Ser Ser Glu Asn Met Lys Pro Ala Asn 
    770                 775                 780                 


Leu Ser His His Leu Lys Thr Lys His Ser Glu Leu Glu Asn Lys Pro 
785                 790                 795                 800 


Val Asp Phe Phe Glu Gln Lys Ser Leu Glu Met Glu Cys Gln Asn Ser 
                805                 810                 815     


Ser Leu Lys Lys Cys Leu Leu Val Glu Lys Ser Leu Val Lys Ala Ser 
            820                 825                 830         


Tyr Leu Ile Ala Phe Gln Thr Ala Ala Ser Lys Lys Pro Phe Ser Ile 
        835                 840                 845             


Ala Glu Glu Leu Ile Lys Pro Tyr Leu Val Glu Met Cys Ser Glu Val 
    850                 855                 860                 


Leu Gly Ser Ser Ala Gly Asp Lys Met Lys Thr Ile Pro Leu Ser Asn 
865                 870                 875                 880 


Val Thr Ile Gln His Arg Ile Asp Glu Leu Ser Ala Asp Ile Glu Asp 
                885                 890                 895     


Gln Leu Ile Gln Lys Val Arg Glu Ser Lys Trp Phe Ala Leu Gln Ile 
            900                 905                 910         


Asp Glu Ser Ser Glu Ile Ser Asn Ile Thr Leu Leu Leu Cys Tyr Ile 
        915                 920                 925             


Arg Phe Ile Asp Tyr Asp Cys Arg Asp Val Lys Glu Glu Leu Leu Phe 
    930                 935                 940                 


Cys Ile Glu Met Pro Thr Gln Ile Thr Gly Phe Glu Ile Phe Glu Leu 
945                 950                 955                 960 


Ile Asn Lys Tyr Ile Asp Ser Lys Ser Leu Asn Trp Lys His Cys Val 
                965                 970                 975     


Gly Leu Cys Thr Asp Gly Ala Ala Ser Met Thr Gly Arg Tyr Ser Gly 
            980                 985                 990         


Leu Lys Ala Lys Ile Gln Glu Val  Ala Met Asn Thr Ala  Ala Phe Thr 
        995                 1000                 1005             


His Cys  Phe Ile His Arg Glu  Arg Leu Val Ala Glu  Lys Leu Ser 
    1010                 1015                 1020             


Pro Cys  Leu His Lys Ile Leu  Leu Gln Ser Ala Gln  Ile Leu Ser 
    1025                 1030                 1035             


Phe Ile  Lys Ser Asn Ala Leu  Asn Ser Arg Met Leu  Thr Ile Leu 
    1040                 1045                 1050             


Cys Glu  Glu Met Gly Ser Glu  His Val Ser Leu Pro  Leu His Ala 
    1055                 1060                 1065             


Glu Val  Arg Trp Ile Ser Arg  Gly Arg Met Leu Lys  Arg Leu Phe 
    1070                 1075                 1080             


Glu Leu  Arg His Glu Ile Glu  Ile Phe Leu Ser Gln  Lys His Ser 
    1085                 1090                 1095             


Asp Leu  Ala Lys Tyr Phe His  Asp Glu Glu Trp Val  Gly Lys Leu 
    1100                 1105                 1110             


Ala Tyr  Leu Ser Asp Ile Phe  Ser Leu Ile Asn Glu  Leu Asn Leu 
    1115                 1120                 1125             


Ser Leu  Gln Gly Thr Leu Thr  Thr Phe Phe Asn Leu  Cys Asn Lys 
    1130                 1135                 1140             


Ile Asp  Val Phe Lys Arg Lys  Leu Lys Met Trp Leu  Lys Arg Thr 
    1145                 1150                 1155             


Gln Glu  Asn Asp Tyr Asp Met  Phe Pro Ser Phe Ser  Glu Phe Ser 
    1160                 1165                 1170             


Asn Ser  Ser Gly Leu Asn Met  Thr Asp Ile Thr Arg  Ile Ile Phe 
    1175                 1180                 1185             


Glu His  Leu Glu Gly Leu Ser  Gln Val Phe Ser Asp  Cys Phe Pro 
    1190                 1195                 1200             


Pro Glu  Gln Asp Leu Arg Ser  Gly Asn Leu Trp Ile  Ile His Pro 
    1205                 1210                 1215             


Phe Met  Asn His Gln Asn Asn  Asn Leu Thr Asp Phe  Glu Glu Glu 
    1220                 1225                 1230             


Lys Leu  Thr Glu Leu Ser Ser  Asp Leu Gly Leu Gln  Ala Leu Phe 
    1235                 1240                 1245             


Lys Ser  Val Ser Val Thr Gln  Phe Trp Ile Asn Ala  Lys Thr Ser 
    1250                 1255                 1260             


Tyr Pro  Glu Leu His Glu Arg  Ala Met Lys Phe Leu  Leu Pro Phe 
    1265                 1270                 1275             


Ser Thr  Val Tyr Leu Cys Asp  Ala Ala Phe Ser Ala  Leu Thr Glu 
    1280                 1285                 1290             


Ser Lys  Gln Lys Asn Leu Leu  Gly Ser Gly Pro Ala  Leu Arg Leu 
    1295                 1300                 1305             


Ala Val  Thr Ser Leu Ile Pro  Arg Ile Glu Lys Leu  Val Lys Glu 
    1310                 1315                 1320             


Lys Glu  
    1325 


<210>  951
<211>  156
<212>  PRT
<213>  Homo sapiens

<400>  951

Met Lys Glu Pro Leu Asp Gly Glu Cys Gly Lys Ala Val Val Pro Gln 
1               5                   10                  15      


Gln Glu Leu Leu Asp Lys Ile Lys Glu Glu Pro Asp Asn Ala Gln Glu 
            20                  25                  30          


Tyr Gly Cys Val Gln Gln Pro Lys Thr Gln Glu Ser Lys Leu Lys Ile 
        35                  40                  45              


Gly Gly Val Ser Ser Val Asn Glu Arg Pro Ile Ala Gln Gln Leu Asn 
    50                  55                  60                  


Pro Gly Phe Gln Leu Ser Phe Ala Ser Ser Gly Pro Ser Val Leu Leu 
65                  70                  75                  80  


Pro Ser Val Pro Ala Val Ala Ile Lys Val Phe Cys Ser Gly Cys Lys 
                85                  90                  95      


Lys Met Leu Tyr Lys Gly Gln Thr Ala Tyr His Lys Thr Gly Ser Thr 
            100                 105                 110         


Gln Leu Phe Cys Ser Thr Arg Cys Ile Thr Arg His Ser Ser Pro Ala 
        115                 120                 125             


Cys Leu Pro Pro Pro Pro Lys Lys Thr Cys Thr Asn Cys Ser Lys Tyr 
    130                 135                 140                 


Lys Ile Leu Asn Ile Pro Phe Tyr Phe Thr Phe Phe 
145                 150                 155     


<210>  952
<211>  1275
<212>  DNA
<213>  Homo sapiens

<400>  952
gggacttcag actccagttt atctgtgccc cagcttcctc acttagtctc agaagactta       60

ggctgaggcc tcagaaggag atctccatcc tttgtccaga gcagaacagg atggccatgt      120

cccaggaatc attgaccttc aaggacgtgt ttgtggactt caccctggag gagtggcagc      180

aactggactc tgcccagaag aacctctaca gggatgtcat gcttgagaac tacagccacc      240

tggtgtccgt ggggtatcta gttgcgaagc cagatgtgat cttcaggttg ggaccaggtg      300

aagagtcctg gatggcagat ggggggaccc cggtacggac ctgtgcaggt gaggacaggc      360

cagatgtatc catttttgcc tcatgtattt tgaagtgctg ttattagtct ggcaagttga      420

tgagcagata gatcactaca aggaaagcca agacaaactt ccttggcaag ctgcattcat      480

aggcaaggaa acactgaagg atgaaagcgg tcaagaatcc agaacatgta gaaaaagcat      540

ttatctgagc acagaatttg attctgtaag gcaaagactc cctaaatatt attcgtggga      600

aaaggcattc aaaacatcat ttaaactttc ttggtcaaaa tggaagctat gtaagaaaga      660

aagatgatgg atgtaaagca tattggaaag tatgcttcca ttataatctt cataaagctc      720

aacctgcaga gagatttttt gaccctaatc aacgagggaa agccctccac caaaagcaag      780

cccttagaaa aagtcagaga agtcaaactg gggagaaact ctacaaatgt actgaatgtg      840

gaaaagtgtt tatccagaaa gcaaacttag ttgtacatca aagaactcac accggagaga      900

aaccttatga atgctgcgaa tgtgcaaaag ccttcagcca gaagtcaacc ctcatagcac      960

accagagaac tcacacaggg gagaagccct atgaatgcag tgaatgtgga aaaaccttta     1020

tccagaagtc aactctgatt aaacataaga aaattcatat ggagagagac cctataaatg     1080

cagtgtctgt gagaaagcct tcagtaggaa gtcaactctc attaaacatc agataattca     1140

tatgggagaa accttatgaa tgtaataaat gtgggaaatc ttttagtgtt aaatcaactc     1200

tcattgtatg tcacagaaca taaatgcata agttgcatgc tattgtaaaa aaaaaaaaaa     1260

aaaaaaaaaa aaaaa                                                      1275


<210>  953
<211>  171
<212>  PRT
<213>  Homo sapiens

<400>  953

Met Ala Met Ser Gln Glu Ser Leu Thr Phe Lys Asp Val Phe Val Asp 
1               5                   10                  15      


Phe Thr Leu Glu Glu Trp Gln Gln Leu Asp Ser Ala Gln Lys Asn Leu 
            20                  25                  30          


Tyr Arg Asp Val Met Leu Glu Asn Tyr Ser His Leu Val Ser Val Gly 
        35                  40                  45              


Tyr Leu Val Ala Lys Pro Asp Val Ile Phe Arg Leu Gly Pro Gly Glu 
    50                  55                  60                  


Glu Ser Trp Met Ala Asp Gly Gly Thr Pro Val Arg Thr Cys Ala Gly 
65                  70                  75                  80  


Glu Asp Arg Pro Glu Val Trp Gln Val Asp Glu Gln Ile Asp His Tyr 
                85                  90                  95      


Lys Glu Ser Gln Asp Lys Leu Pro Trp Gln Ala Ala Phe Ile Gly Lys 
            100                 105                 110         


Glu Thr Leu Lys Asp Glu Ser Gly Gln Glu Ser Arg Thr Cys Arg Lys 
        115                 120                 125             


Ser Ile Tyr Leu Ser Thr Glu Phe Asp Ser Val Arg Gln Arg Leu Pro 
    130                 135                 140                 


Lys Tyr Tyr Ser Trp Glu Lys Ala Phe Lys Thr Ser Phe Lys Leu Ser 
145                 150                 155                 160 


Trp Ser Lys Trp Lys Leu Cys Lys Lys Glu Arg 
                165                 170     


<210>  954
<211>  98
<212>  PRT
<213>  Homo sapiens

<400>  954

Met Ala Met Ser Gln Glu Ser Leu Thr Phe Lys Asp Val Phe Val Asp 
1               5                   10                  15      


Phe Thr Leu Glu Glu Trp Gln Gln Leu Asp Ser Ala Gln Lys Asn Leu 
            20                  25                  30          


Tyr Arg Asp Val Met Leu Glu Asn Tyr Ser His Leu Val Ser Val Gly 
        35                  40                  45              


Tyr Leu Val Ala Lys Pro Asp Val Ile Phe Arg Leu Gly Pro Gly Glu 
    50                  55                  60                  


Glu Ser Trp Met Ala Asp Gly Gly Thr Pro Val Arg Thr Cys Ala Gly 
65                  70                  75                  80  


Glu Asp Arg Pro Asp Val Ser Ile Phe Ala Ser Cys Ile Leu Lys Cys 
                85                  90                  95      


Cys Tyr 
        


<210>  955
<211>  762
<212>  DNA
<213>  Homo sapiens

<400>  955
gggggcagag ctggcgctct agcccacgga gttggttaac tcctctcacc ggcccctgga       60

aagggttcca agtcctttag tacccgacgc tgtctgggaa ttccgggcgt ttcggctcct      120

tggtcgcaga ggcaggaggc acccgaccgc atgtctgtca tggacctcgc caatacttgc      180

tccagctttc agtcggacct ggatttctgt tcagattgcg gctcggtcct gcctctgccc      240

ggggctcagg atacggtcac ctgtattcgc tgtggcttca acatcaacgt tcgggacttt      300

gaggggaagg ttgtgaagac ttcggttgtg ttccaccaac tggggacagc catgcctatg      360

tcggtggagg aagggcctga gtgccaggga cctgtggttg acaggcgctg ccctcgatgt      420

ggtcatgaag gaatggcata ccacaccaga cagatgcgtt cagccgatga agggcaaact      480

gtcttctaca cctgtaccaa ctgcaagttc caggagaagg aagactcttg accttttttc      540

ctgggcaact ctacagtccc tccctccttt cggaaggtga aggatactgg gtttttagat      600

gccttgtcca tcctgtctgg ttgcaatgtt ttgctcccag aagagaatca gatcatcatg      660

tggggattac cattgttcct ggagtactcc tacccttagt tgaatttcct tattaaagtt      720

atatttttct ataaaaaaaa aaaaaaaaaa aaaaaaaaaa aa                         762


<210>  956
<211>  126
<212>  PRT
<213>  Homo sapiens

<400>  956

Met Ser Val Met Asp Leu Ala Asn Thr Cys Ser Ser Phe Gln Ser Asp 
1               5                   10                  15      


Leu Asp Phe Cys Ser Asp Cys Gly Ser Val Leu Pro Leu Pro Gly Ala 
            20                  25                  30          


Gln Asp Thr Val Thr Cys Ile Arg Cys Gly Phe Asn Ile Asn Val Arg 
        35                  40                  45              


Asp Phe Glu Gly Lys Val Val Lys Thr Ser Val Val Phe His Gln Leu 
    50                  55                  60                  


Gly Thr Ala Met Pro Met Ser Val Glu Glu Gly Pro Glu Cys Gln Gly 
65                  70                  75                  80  


Pro Val Val Asp Arg Arg Cys Pro Arg Cys Gly His Glu Gly Met Ala 
                85                  90                  95      


Tyr His Thr Arg Gln Met Arg Ser Ala Asp Glu Gly Gln Thr Val Phe 
            100                 105                 110         


Tyr Thr Cys Thr Asn Cys Lys Phe Gln Glu Lys Glu Asp Ser 
        115                 120                 125     


<210>  957
<211>  126
<212>  PRT
<213>  Homo sapiens

<400>  957

Met Ser Val Met Asp Leu Ala Asn Thr Cys Ser Ser Phe Gln Ser Asp 
1               5                   10                  15      


Leu Asp Phe Cys Ser Asp Cys Gly Ser Val Leu Pro Leu Pro Gly Ala 
            20                  25                  30          


Gln Asp Thr Val Thr Cys Ile Arg Cys Gly Phe Asn Ile Asn Val Arg 
        35                  40                  45              


Asp Phe Glu Gly Lys Val Val Lys Thr Ser Val Val Phe His Gln Leu 
    50                  55                  60                  


Gly Thr Ala Met Pro Met Ser Val Glu Glu Gly Pro Glu Cys Gln Gly 
65                  70                  75                  80  


Pro Val Val Asp Arg Arg Cys Pro Arg Cys Gly His Glu Gly Met Ala 
                85                  90                  95      


Tyr His Thr Arg Gln Met Arg Ser Ala Asp Glu Gly Gln Thr Val Phe 
            100                 105                 110         


Tyr Thr Cys Thr Asn Cys Lys Phe Gln Glu Lys Glu Asp Ser 
        115                 120                 125     


