                         SEQUENCE LISTING

<110>  Steinfeld, Robert
 
<120>  SUBSTANCES AND METHODS FOR THE TREATMENT OF LYSOSMAL STORAGE 
       DISEASES

<130>  R2546 PCT BLN

<150>  EP 09 17 9047.7
<151>  2009-12-14

<160>  74    

<170>  PatentIn version 3.5

<210>  1
<211>  16
<212>  PRT
<213>  Homo sapiens

<400>  1

Lys Ile Arg Ser Glu Phe Lys Lys Lys Tyr Gly Lys Ser Leu Tyr Tyr 
1               5                   10                  15      


<210>  2
<211>  16
<212>  PRT
<213>  Homo sapiens

<400>  2

Gln Arg Phe Arg His Arg Asn Arg Lys Gly Tyr Arg Ser Gln Arg Gly 
1               5                   10                  15      


<210>  3
<211>  16
<212>  PRT
<213>  Homo sapiens

<400>  3

Lys Phe Ile Ile Pro Ser Pro Lys Arg Pro Val Lys Leu Leu Ser Gly 
1               5                   10                  15      


<210>  4
<211>  16
<212>  PRT
<213>  Homo sapiens

<400>  4

Gly His Phe Lys Asp Pro Lys Arg Leu Tyr Cys Lys Asn Gly Gly Phe 
1               5                   10                  15      


<210>  5
<211>  16
<212>  PRT
<213>  Homo sapiens

<400>  5

Asp Gly Gly Ser Pro Ile Arg His Tyr Leu Ile Lys Tyr Lys Ala Lys 
1               5                   10                  15      


<210>  6
<211>  16
<212>  PRT
<213>  Homo sapiens

<400>  6

Gly Leu Ser Glu Lys Thr Leu Arg Lys Trp Leu Lys Met Phe Lys Lys 
1               5                   10                  15      


<210>  7
<211>  16
<212>  PRT
<213>  Homo sapiens

<400>  7

Lys Leu Asn Cys Arg Leu Tyr Arg Lys Ala Asn Lys Ser Ser Lys Leu 
1               5                   10                  15      


<210>  8
<211>  16
<212>  PRT
<213>  Homo sapiens

<400>  8

Ser His Leu Arg Lys Leu Arg Lys Arg Leu Leu Arg Asp Ala Asp Asp 
1               5                   10                  15      


<210>  9
<211>  16
<212>  PRT
<213>  Homo sapiens

<400>  9

Gly His Arg Pro Leu Asp Lys Lys Arg Glu Glu Ala Pro Ser Leu Arg 
1               5                   10                  15      


<210>  10
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  10

Ser Arg Gly Lys Gly Arg Arg Gly Gln Arg Gly Lys Asn Arg Gly 
1               5                   10                  15  


<210>  11
<211>  16
<212>  PRT
<213>  Homo sapiens

<400>  11

Pro Asp Ala Pro Arg Ile Lys Lys Ile Val Gln Lys Lys Leu Ala Gly 
1               5                   10                  15      


<210>  12
<211>  16
<212>  PRT
<213>  Homo sapiens

<400>  12

Asp Lys Lys Gly Phe Tyr Lys Lys Lys Gln Cys Arg Pro Ser Lys Gly 
1               5                   10                  15      


<210>  13
<211>  16
<212>  PRT
<213>  Homo sapiens

<400>  13

Arg Gln Ile Lys Ile Trp Phe Gln Asn Arg Arg Met Lys Trp Lys Lys 
1               5                   10                  15      


<210>  14
<211>  13
<212>  PRT
<213>  Homo sapiens

<400>  14

Lys Arg Val Ser Arg Asn Lys Ser Glu Lys Lys Arg Arg 
1               5                   10              


<210>  15
<211>  12
<212>  DNA
<213>  Homo sapiens

<400>  15
agatcccccg gg                                                           12


<210>  16
<211>  12
<212>  DNA
<213>  Homo sapiens

<400>  16
ggatcccccg gg                                                           12


<210>  17
<211>  51
<212>  DNA
<213>  Homo sapiens

<400>  17
cgccagataa agatttggtt ccagaatcgg cgcatgaagt ggaagaagta a                51


<210>  18
<211>  16
<212>  PRT
<213>  Homo sapiens

<400>  18

Arg Gln Ile Lys Ile Trp Phe Gln Asn Arg Arg Met Lys Trp Lys Lys 
1               5                   10                  15      


<210>  19
<211>  42
<212>  DNA
<213>  Homo sapiens

<400>  19
aaaagagtat ctagaaacaa atctgaaaag aaacgtagat aa                          42


<210>  20
<211>  13
<212>  PRT
<213>  Homo sapiens

<400>  20

Lys Arg Val Ser Arg Asn Lys Ser Glu Lys Lys Arg Arg 
1               5                   10              


<210>  21
<211>  30
<212>  DNA
<213>  Homo sapiens

<400>  21
agatccgtcg acatcgaagg tagaggcatt                                        30


<210>  22
<211>  30
<212>  DNA
<213>  Homo sapiens

<400>  22
ggatccgtcg acatcgaagg tagaggcatt                                        30


<210>  23
<211>  441
<212>  DNA
<213>  Homo sapiens

<400>  23
cccgccttgc ccgaggatgg cggcagcggc gccttcccgc ccggccactt caaggacccc       60

aagcggctgt actgcaaaaa cgggggcttc ttcctgcgca tccaccccga cggccgagtt      120

gacggggtcc gggagaagag cgaccctcac atcaagctac aacttcaagc agaagagaga      180

ggagttgtgt ctatcaaagg agtgtctgct aaccgttacc tggctatgaa ggaagatgga      240

agattactgg cttctaaatc tgttacggat gagtgtttct tttttgaacg attggaatct      300

aataactaca atacttaccg gtcaaggaaa tacaccagtt ggtatgtggc actgaaacga      360

actgggcagt ataaacttgg ctccaaaaca ggacctgggc agaaagctat actttttctt      420

ccaatgtctg ctaagagctg a                                                441


<210>  24
<211>  145
<212>  PRT
<213>  Homo sapiens

<400>  24

Pro Ala Leu Pro Glu Asp Gly Gly Ser Gly Ala Phe Pro Pro Gly His 
1               5                   10                  15      


Phe Lys Asp Pro Lys Arg Leu Tyr Cys Lys Asn Gly Gly Phe Phe Leu 
            20                  25                  30          


Arg Ile His Pro Asp Gly Arg Val Asp Gly Val Arg Glu Lys Ser Asp 
        35                  40                  45              


Pro His Ile Lys Leu Gln Leu Gln Ala Glu Glu Arg Gly Val Val Ser 
    50                  55                  60                  


Ile Lys Gly Val Ser Ala Asn Arg Tyr Leu Ala Met Lys Glu Asp Gly 
65                  70                  75                  80  


Arg Leu Leu Ala Ser Lys Ser Val Thr Asp Glu Cys Phe Phe Phe Glu 
                85                  90                  95      


Arg Leu Glu Ser Asn Asn Tyr Asn Thr Tyr Arg Ser Arg Lys Tyr Thr 
            100                 105                 110         


Ser Trp Tyr Val Ala Leu Lys Arg Thr Gly Gln Tyr Lys Leu Gly Ser 
        115                 120                 125             


Lys Thr Gly Pro Gly Gln Lys Ala Ile Leu Phe Leu Pro Met Ser Ala 
    130                 135                 140                 


Lys 
145 


<210>  25
<211>  441
<212>  DNA
<213>  Homo sapiens

<400>  25
cccgccttgc ccgaggatgg cggcagcggc gccttcccgc ccggccactt caaggacccc       60

aagcggctgt actgcaaaaa cgggggcttc ttcctgcgca tccaccccga cggccgagtt      120

gacggggtcc gggagaagag cgaccctcac atcaagctac aacttcaagc agaagagaga      180

ggagttgtgt ctatcaaagg agtgtctgct aaccgttacc tggctatgaa ggaagatgga      240

agattactgg cttctaaatc tgttacggat gagtgtttct tttttgcacg attggaatct      300

aataactaca atacttaccg gtcaaggaaa tacaccagtt ggtatgtggc actgaaacga      360

actgggcagt ataaacttgg ctccaaaaca ggacctgggc agaaagctat actttttctt      420

ccaatgtctg ctaagagctg a                                                441


<210>  26
<211>  146
<212>  PRT
<213>  Homo sapiens

<400>  26

Pro Ala Leu Pro Glu Asp Gly Gly Ser Gly Ala Phe Pro Pro Gly His 
1               5                   10                  15      


Phe Lys Asp Pro Lys Arg Leu Tyr Cys Lys Asn Gly Gly Phe Phe Leu 
            20                  25                  30          


Arg Ile His Pro Asp Gly Arg Val Asp Gly Val Arg Glu Lys Ser Asp 
        35                  40                  45              


Pro His Ile Lys Leu Gln Leu Gln Ala Glu Glu Arg Gly Val Val Ser 
    50                  55                  60                  


Ile Lys Gly Val Ser Ala Asn Arg Tyr Leu Ala Met Lys Glu Asp Gly 
65                  70                  75                  80  


Arg Leu Leu Ala Ser Lys Ser Val Thr Asp Glu Cys Phe Phe Phe Ala 
                85                  90                  95      


Arg Leu Glu Ser Asn Asn Tyr Asn Thr Tyr Arg Ser Arg Lys Tyr Thr 
            100                 105                 110         


Ser Trp Tyr Val Ala Leu Lys Arg Thr Gly Gln Tyr Lys Leu Gly Ser 
        115                 120                 125             


Lys Thr Gly Pro Gly Gln Lys Ala Ile Leu Phe Leu Pro Met Ser Ala 
    130                 135                 140                 


Lys Ser 
145     


<210>  27
<211>  441
<212>  DNA
<213>  Homo sapiens

<400>  27
cccgccttgc ccgaggatgg cggcagcggc gccttcccgc ccggccactt caaggacccc       60

aagcggctgt actgcaaaaa cgggggcttc ttcctgcgca tccaccccga cggccgagtt      120

gacgggacaa gggacaggag cgaccagcac attcagctgc agctcagtgc agaagagaga      180

ggagttgtgt ctatcaaagg agtgtctgct aaccgttacc tggctatgaa ggaagatgga      240

agattactgg cttctaaatc tgttacggat gagtgtttct tttttgaacg attggaatct      300

aataactaca atacttaccg gtcaaggaaa tacaccagtt ggtatgtggc actgaaacga      360

actgggcagt ataaacttgg ctccaaaaca ggacctgggc agaaagctat actttttctt      420

ccaatgtctg ctaagagctg a                                                441


<210>  28
<211>  146
<212>  PRT
<213>  Homo sapiens

<400>  28

Pro Ala Leu Pro Glu Asp Gly Gly Ser Gly Ala Phe Pro Pro Gly His 
1               5                   10                  15      


Phe Lys Asp Pro Lys Arg Leu Tyr Cys Lys Asn Gly Gly Phe Phe Leu 
            20                  25                  30          


Arg Ile His Pro Asp Gly Arg Val Asp Gly Thr Arg Asp Arg Ser Asp 
        35                  40                  45              


Gln His Ile Gln Leu Gln Leu Ser Ala Glu Glu Arg Gly Val Val Ser 
    50                  55                  60                  


Ile Lys Gly Val Ser Ala Asn Arg Tyr Leu Ala Met Lys Glu Asp Gly 
65                  70                  75                  80  


Arg Leu Leu Ala Ser Lys Ser Val Thr Asp Glu Cys Phe Phe Phe Glu 
                85                  90                  95      


Arg Leu Glu Ser Asn Asn Tyr Asn Thr Tyr Arg Ser Arg Lys Tyr Thr 
            100                 105                 110         


Ser Trp Tyr Val Ala Leu Lys Arg Thr Gly Gln Tyr Lys Leu Gly Ser 
        115                 120                 125             


Lys Thr Gly Pro Gly Gln Lys Ala Ile Leu Phe Leu Pro Met Ser Ala 
    130                 135                 140                 


Lys Ser 
145     


<210>  29
<211>  441
<212>  DNA
<213>  Homo sapiens

<400>  29
cccgccttgc ccgaggatgg cggcagcggc gccttcccgc ccggccactt caaggacccc       60

aagcggctgt actgcaaaaa cgggggcttc ttcctgcgca tccaccccga cggccgagtt      120

gacgggacaa gggacaggag cgaccagcac attcagctgc agctcagtgc agaagagaga      180

ggagttgtgt ctatcaaagg agtgtctgct aaccgttacc tggctatgaa ggaagatgga      240

agattactgg cttctaaatc tgttacggat gagtgtttct tttttgcacg attggaatct      300

aataactaca atacttaccg gtcaaggaaa tacaccagtt ggtatgtggc actgaaacga      360

actgggcagt ataaacttgg ctccaaaaca ggacctgggc agaaagctat actttttctt      420

ccaatgtctg ctaagagctg a                                                441


<210>  30
<211>  146
<212>  PRT
<213>  Homo sapiens

<400>  30

Pro Ala Leu Pro Glu Asp Gly Gly Ser Gly Ala Phe Pro Pro Gly His 
1               5                   10                  15      


Phe Lys Asp Pro Lys Arg Leu Tyr Cys Lys Asn Gly Gly Phe Phe Leu 
            20                  25                  30          


Arg Ile His Pro Asp Gly Arg Val Asp Gly Thr Arg Asp Arg Ser Asp 
        35                  40                  45              


Gln His Ile Gln Leu Gln Leu Ser Ala Glu Glu Arg Gly Val Val Ser 
    50                  55                  60                  


Ile Lys Gly Val Ser Ala Asn Arg Tyr Leu Ala Met Lys Glu Asp Gly 
65                  70                  75                  80  


Arg Leu Leu Ala Ser Lys Ser Val Thr Asp Glu Cys Phe Phe Phe Ala 
                85                  90                  95      


Arg Leu Glu Ser Asn Asn Tyr Asn Thr Tyr Arg Ser Arg Lys Tyr Thr 
            100                 105                 110         


Ser Trp Tyr Val Ala Leu Lys Arg Thr Gly Gln Tyr Lys Leu Gly Ser 
        115                 120                 125             


Lys Thr Gly Pro Gly Gln Lys Ala Ile Leu Phe Leu Pro Met Ser Ala 
    130                 135                 140                 


Lys Ser 
145     


<210>  31
<211>  1752
<212>  DNA
<213>  Homo sapiens

<400>  31
atgggactcc aagcctgcct cctagggctc tttgccctca tcctctctgg caaatgcagt       60

tacagcccgg agcccgacca gcggaggacg ctgcccccag gctgggtgtc cctgggccgt      120

gcggaccctg aggaagagct gagtctcacc tttgccctga gacagcagaa tgtggaaaga      180

ctctcggagc tggtgcaggc tgtgtcggat cccagctctc ctcaatacgg aaaatacctg      240

accctagaga atgtggctga tctggtgagg ccatccccac tgaccctcca cacggtgcaa      300

aaatggctct tggcagccgg agcccagaag tgccattctg tgatcacaca ggactttctg      360

acttgctggc tgagcatccg acaagcagag ctgctgctcc ctggggctga gtttcatcac      420

tatgtgggag gacctacgga aacccatgtt gtaaggtccc cacatcccta ccagcttcca      480

caggccttgg ccccccatgt ggactttgtg gggggactgc accgttttcc cccaacatca      540

tccctgaggc aacgtcctga gccgcaggtg acagggactg taggcctgca tctgggggta      600

accccctctg tgatccgtaa gcgatacaac ttgacctcac aagacgtggg ctctggcacc      660

agcaataaca gccaagcctg tgcccagttc ctggagcagt atttccatga ctcagacctg      720

gctcagttca tgcgcctctt cggtggcaac tttgcacatc aggcatcagt agcccgtgtg      780

gttggacaac agggccgggg ccgggccggg attgaggcca gtctagatgt gcagtacctg      840

atgagtgctg gtgccaacat ctccacctgg gtctacagta gccctggccg gcatgaggga      900

caggagccct tcctgcagtg gctcatgctg ctcagtaatg agtcagccct gccacatgtg      960

catactgtga gctatggaga tgatgaggac tccctcagca gcgcctacat ccagcgggtc     1020

aacactgagc tcatgaaggc tgccgctcgg ggtctcaccc tgctcttcgc ctcaggtgac     1080

agtggggccg ggtgttggtc tgtctctgga agacaccagt tccgccctac cttccctgcc     1140

tccagcccct atgtcaccac agtgggaggc acatccttcc aggaaccttt cctcatcaca     1200

aatgaaattg ttgactatat cagtggtggt ggcttcagca atgtgttccc acggccttca     1260

taccaggagg aagctgtaac gaagttcctg agctctagcc cccacctgcc accatccagt     1320

tacttcaatg ccagtggccg tgcctaccca gatgtggctg cactttctga tggctactgg     1380

gtggtcagca acagagtgcc cattccatgg gtgtccggaa cctcggcctc tactccagtg     1440

tttgggggga tcctatcctt gatcaatgag cacaggatcc ttagtggccg cccccctctt     1500

ggctttctca acccaaggct ctaccagcag catggggcag gactctttga tgtaacccgt     1560

ggctgccatg agtcctgtct ggatgaagag gtagagggcc agggtttctg ctctggtcct     1620

ggctgggatc ctgtaacagg ctggggaaca cccaacttcc cagctttgct gaagactcta     1680

ctcaacccca gatcccccgg gcgccagata aagatttggt tccagaatcg gcgcatgaag     1740

tggaagaagt aa                                                         1752


<210>  32
<211>  583
<212>  PRT
<213>  Homo sapiens

<400>  32

Met Gly Leu Gln Ala Cys Leu Leu Gly Leu Phe Ala Leu Ile Leu Ser 
1               5                   10                  15      


Gly Lys Cys Ser Tyr Ser Pro Glu Pro Asp Gln Arg Arg Thr Leu Pro 
            20                  25                  30          


Pro Gly Trp Val Ser Leu Gly Arg Ala Asp Pro Glu Glu Glu Leu Ser 
        35                  40                  45              


Leu Thr Phe Ala Leu Arg Gln Gln Asn Val Glu Arg Leu Ser Glu Leu 
    50                  55                  60                  


Val Gln Ala Val Ser Asp Pro Ser Ser Pro Gln Tyr Gly Lys Tyr Leu 
65                  70                  75                  80  


Thr Leu Glu Asn Val Ala Asp Leu Val Arg Pro Ser Pro Leu Thr Leu 
                85                  90                  95      


His Thr Val Gln Lys Trp Leu Leu Ala Ala Gly Ala Gln Lys Cys His 
            100                 105                 110         


Ser Val Ile Thr Gln Asp Phe Leu Thr Cys Trp Leu Ser Ile Arg Gln 
        115                 120                 125             


Ala Glu Leu Leu Leu Pro Gly Ala Glu Phe His His Tyr Val Gly Gly 
    130                 135                 140                 


Pro Thr Glu Thr His Val Val Arg Ser Pro His Pro Tyr Gln Leu Pro 
145                 150                 155                 160 


Gln Ala Leu Ala Pro His Val Asp Phe Val Gly Gly Leu His Arg Phe 
                165                 170                 175     


Pro Pro Thr Ser Ser Leu Arg Gln Arg Pro Glu Pro Gln Val Thr Gly 
            180                 185                 190         


Thr Val Gly Leu His Leu Gly Val Thr Pro Ser Val Ile Arg Lys Arg 
        195                 200                 205             


Tyr Asn Leu Thr Ser Gln Asp Val Gly Ser Gly Thr Ser Asn Asn Ser 
    210                 215                 220                 


Gln Ala Cys Ala Gln Phe Leu Glu Gln Tyr Phe His Asp Ser Asp Leu 
225                 230                 235                 240 


Ala Gln Phe Met Arg Leu Phe Gly Gly Asn Phe Ala His Gln Ala Ser 
                245                 250                 255     


Val Ala Arg Val Val Gly Gln Gln Gly Arg Gly Arg Ala Gly Ile Glu 
            260                 265                 270         


Ala Ser Leu Asp Val Gln Tyr Leu Met Ser Ala Gly Ala Asn Ile Ser 
        275                 280                 285             


Thr Trp Val Tyr Ser Ser Pro Gly Arg His Glu Gly Gln Glu Pro Phe 
    290                 295                 300                 


Leu Gln Trp Leu Met Leu Leu Ser Asn Glu Ser Ala Leu Pro His Val 
305                 310                 315                 320 


His Thr Val Ser Tyr Gly Asp Asp Glu Asp Ser Leu Ser Ser Ala Tyr 
                325                 330                 335     


Ile Gln Arg Val Asn Thr Glu Leu Met Lys Ala Ala Ala Arg Gly Leu 
            340                 345                 350         


Thr Leu Leu Phe Ala Ser Gly Asp Ser Gly Ala Gly Cys Trp Ser Val 
        355                 360                 365             


Ser Gly Arg His Gln Phe Arg Pro Thr Phe Pro Ala Ser Ser Pro Tyr 
    370                 375                 380                 


Val Thr Thr Val Gly Gly Thr Ser Phe Gln Glu Pro Phe Leu Ile Thr 
385                 390                 395                 400 


Asn Glu Ile Val Asp Tyr Ile Ser Gly Gly Gly Phe Ser Asn Val Phe 
                405                 410                 415     


Pro Arg Pro Ser Tyr Gln Glu Glu Ala Val Thr Lys Phe Leu Ser Ser 
            420                 425                 430         


Ser Pro His Leu Pro Pro Ser Ser Tyr Phe Asn Ala Ser Gly Arg Ala 
        435                 440                 445             


Tyr Pro Asp Val Ala Ala Leu Ser Asp Gly Tyr Trp Val Val Ser Asn 
    450                 455                 460                 


Arg Val Pro Ile Pro Trp Val Ser Gly Thr Ser Ala Ser Thr Pro Val 
465                 470                 475                 480 


Phe Gly Gly Ile Leu Ser Leu Ile Asn Glu His Arg Ile Leu Ser Gly 
                485                 490                 495     


Arg Pro Pro Leu Gly Phe Leu Asn Pro Arg Leu Tyr Gln Gln His Gly 
            500                 505                 510         


Ala Gly Leu Phe Asp Val Thr Arg Gly Cys His Glu Ser Cys Leu Asp 
        515                 520                 525             


Glu Glu Val Glu Gly Gln Gly Phe Cys Ser Gly Pro Gly Trp Asp Pro 
    530                 535                 540                 


Val Thr Gly Trp Gly Thr Pro Asn Phe Pro Ala Leu Leu Lys Thr Leu 
545                 550                 555                 560 


Leu Asn Pro Arg Ser Pro Gly Arg Gln Ile Lys Ile Trp Phe Gln Asn 
                565                 570                 575     


Arg Arg Met Lys Trp Lys Lys 
            580             


<210>  33
<211>  1743
<212>  DNA
<213>  Homo sapiens

<400>  33
atgggactcc aagcctgcct cctagggctc tttgccctca tcctctctgg caaatgcagt       60

tacagcccgg agcccgacca gcggaggacg ctgcccccag gctgggtgtc cctgggccgt      120

gcggaccctg aggaagagct gagtctcacc tttgccctga gacagcagaa tgtggaaaga      180

ctctcggagc tggtgcaggc tgtgtcggat cccagctctc ctcaatacgg aaaatacctg      240

accctagaga atgtggctga tctggtgagg ccatccccac tgaccctcca cacggtgcaa      300

aaatggctct tggcagccgg agcccagaag tgccattctg tgatcacaca ggactttctg      360

acttgctggc tgagcatccg acaagcagag ctgctgctcc ctggggctga gtttcatcac      420

tatgtgggag gacctacgga aacccatgtt gtaaggtccc cacatcccta ccagcttcca      480

caggccttgg ccccccatgt ggactttgtg gggggactgc accgttttcc cccaacatca      540

tccctgaggc aacgtcctga gccgcaggtg acagggactg taggcctgca tctgggggta      600

accccctctg tgatccgtaa gcgatacaac ttgacctcac aagacgtggg ctctggcacc      660

agcaataaca gccaagcctg tgcccagttc ctggagcagt atttccatga ctcagacctg      720

gctcagttca tgcgcctctt cggtggcaac tttgcacatc aggcatcagt agcccgtgtg      780

gttggacaac agggccgggg ccgggccggg attgaggcca gtctagatgt gcagtacctg      840

atgagtgctg gtgccaacat ctccacctgg gtctacagta gccctggccg gcatgaggga      900

caggagccct tcctgcagtg gctcatgctg ctcagtaatg agtcagccct gccacatgtg      960

catactgtga gctatggaga tgatgaggac tccctcagca gcgcctacat ccagcgggtc     1020

aacactgagc tcatgaaggc tgccgctcgg ggtctcaccc tgctcttcgc ctcaggtgac     1080

agtggggccg ggtgttggtc tgtctctgga agacaccagt tccgccctac cttccctgcc     1140

tccagcccct atgtcaccac agtgggaggc acatccttcc aggaaccttt cctcatcaca     1200

aatgaaattg ttgactatat cagtggtggt ggcttcagca atgtgttccc acggccttca     1260

taccaggagg aagctgtaac gaagttcctg agctctagcc cccacctgcc accatccagt     1320

tacttcaatg ccagtggccg tgcctaccca gatgtggctg cactttctga tggctactgg     1380

gtggtcagca acagagtgcc cattccatgg gtgtccggaa cctcggcctc tactccagtg     1440

tttgggggga tcctatcctt gatcaatgag cacaggatcc ttagtggccg cccccctctt     1500

ggctttctca acccaaggct ctaccagcag catggggcag gactctttga tgtaacccgt     1560

ggctgccatg agtcctgtct ggatgaagag gtagagggcc agggtttctg ctctggtcct     1620

ggctgggatc ctgtaacagg ctggggaaca cccaacttcc cagctttgct gaagactcta     1680

ctcaacccca gatcccccgg gaaaagagta tctagaaaca aatctgaaaa gaaacgtaga     1740

taa                                                                   1743


<210>  34
<211>  580
<212>  PRT
<213>  Homo sapiens

<400>  34

Met Gly Leu Gln Ala Cys Leu Leu Gly Leu Phe Ala Leu Ile Leu Ser 
1               5                   10                  15      


Gly Lys Cys Ser Tyr Ser Pro Glu Pro Asp Gln Arg Arg Thr Leu Pro 
            20                  25                  30          


Pro Gly Trp Val Ser Leu Gly Arg Ala Asp Pro Glu Glu Glu Leu Ser 
        35                  40                  45              


Leu Thr Phe Ala Leu Arg Gln Gln Asn Val Glu Arg Leu Ser Glu Leu 
    50                  55                  60                  


Val Gln Ala Val Ser Asp Pro Ser Ser Pro Gln Tyr Gly Lys Tyr Leu 
65                  70                  75                  80  


Thr Leu Glu Asn Val Ala Asp Leu Val Arg Pro Ser Pro Leu Thr Leu 
                85                  90                  95      


His Thr Val Gln Lys Trp Leu Leu Ala Ala Gly Ala Gln Lys Cys His 
            100                 105                 110         


Ser Val Ile Thr Gln Asp Phe Leu Thr Cys Trp Leu Ser Ile Arg Gln 
        115                 120                 125             


Ala Glu Leu Leu Leu Pro Gly Ala Glu Phe His His Tyr Val Gly Gly 
    130                 135                 140                 


Pro Thr Glu Thr His Val Val Arg Ser Pro His Pro Tyr Gln Leu Pro 
145                 150                 155                 160 


Gln Ala Leu Ala Pro His Val Asp Phe Val Gly Gly Leu His Arg Phe 
                165                 170                 175     


Pro Pro Thr Ser Ser Leu Arg Gln Arg Pro Glu Pro Gln Val Thr Gly 
            180                 185                 190         


Thr Val Gly Leu His Leu Gly Val Thr Pro Ser Val Ile Arg Lys Arg 
        195                 200                 205             


Tyr Asn Leu Thr Ser Gln Asp Val Gly Ser Gly Thr Ser Asn Asn Ser 
    210                 215                 220                 


Gln Ala Cys Ala Gln Phe Leu Glu Gln Tyr Phe His Asp Ser Asp Leu 
225                 230                 235                 240 


Ala Gln Phe Met Arg Leu Phe Gly Gly Asn Phe Ala His Gln Ala Ser 
                245                 250                 255     


Val Ala Arg Val Val Gly Gln Gln Gly Arg Gly Arg Ala Gly Ile Glu 
            260                 265                 270         


Ala Ser Leu Asp Val Gln Tyr Leu Met Ser Ala Gly Ala Asn Ile Ser 
        275                 280                 285             


Thr Trp Val Tyr Ser Ser Pro Gly Arg His Glu Gly Gln Glu Pro Phe 
    290                 295                 300                 


Leu Gln Trp Leu Met Leu Leu Ser Asn Glu Ser Ala Leu Pro His Val 
305                 310                 315                 320 


His Thr Val Ser Tyr Gly Asp Asp Glu Asp Ser Leu Ser Ser Ala Tyr 
                325                 330                 335     


Ile Gln Arg Val Asn Thr Glu Leu Met Lys Ala Ala Ala Arg Gly Leu 
            340                 345                 350         


Thr Leu Leu Phe Ala Ser Gly Asp Ser Gly Ala Gly Cys Trp Ser Val 
        355                 360                 365             


Ser Gly Arg His Gln Phe Arg Pro Thr Phe Pro Ala Ser Ser Pro Tyr 
    370                 375                 380                 


Val Thr Thr Val Gly Gly Thr Ser Phe Gln Glu Pro Phe Leu Ile Thr 
385                 390                 395                 400 


Asn Glu Ile Val Asp Tyr Ile Ser Gly Gly Gly Phe Ser Asn Val Phe 
                405                 410                 415     


Pro Arg Pro Ser Tyr Gln Glu Glu Ala Val Thr Lys Phe Leu Ser Ser 
            420                 425                 430         


Ser Pro His Leu Pro Pro Ser Ser Tyr Phe Asn Ala Ser Gly Arg Ala 
        435                 440                 445             


Tyr Pro Asp Val Ala Ala Leu Ser Asp Gly Tyr Trp Val Val Ser Asn 
    450                 455                 460                 


Arg Val Pro Ile Pro Trp Val Ser Gly Thr Ser Ala Ser Thr Pro Val 
465                 470                 475                 480 


Phe Gly Gly Ile Leu Ser Leu Ile Asn Glu His Arg Ile Leu Ser Gly 
                485                 490                 495     


Arg Pro Pro Leu Gly Phe Leu Asn Pro Arg Leu Tyr Gln Gln His Gly 
            500                 505                 510         


Ala Gly Leu Phe Asp Val Thr Arg Gly Cys His Glu Ser Cys Leu Asp 
        515                 520                 525             


Glu Glu Val Glu Gly Gln Gly Phe Cys Ser Gly Pro Gly Trp Asp Pro 
    530                 535                 540                 


Val Thr Gly Trp Gly Thr Pro Asn Phe Pro Ala Leu Leu Lys Thr Leu 
545                 550                 555                 560 


Leu Asn Pro Arg Ser Pro Gly Lys Arg Val Ser Arg Asn Lys Ser Glu 
                565                 570                 575     


Lys Lys Arg Arg 
            580 


<210>  35
<211>  2160
<212>  DNA
<213>  Homo sapiens

<400>  35
atgggactcc aagcctgcct cctagggctc tttgccctca tcctctctgg caaatgcagt       60

tacagcccgg agcccgacca gcggaggacg ctgcccccag gctgggtgtc cctgggccgt      120

gcggaccctg aggaagagct gagtctcacc tttgccctga gacagcagaa tgtggaaaga      180

ctctcggagc tggtgcaggc tgtgtcggat cccagctctc ctcaatacgg aaaatacctg      240

accctagaga atgtggctga tctggtgagg ccatccccac tgaccctcca cacggtgcaa      300

aaatggctct tggcagccgg agcccagaag tgccattctg tgatcacaca ggactttctg      360

acttgctggc tgagcatccg acaagcagag ctgctgctcc ctggggctga gtttcatcac      420

tatgtgggag gacctacgga aacccatgtt gtaaggtccc cacatcccta ccagcttcca      480

caggccttgg ccccccatgt ggactttgtg gggggactgc accgttttcc cccaacatca      540

tccctgaggc aacgtcctga gccgcaggtg acagggactg taggcctgca tctgggggta      600

accccctctg tgatccgtaa gcgatacaac ttgacctcac aagacgtggg ctctggcacc      660

agcaataaca gccaagcctg tgcccagttc ctggagcagt atttccatga ctcagacctg      720

gctcagttca tgcgcctctt cggtggcaac tttgcacatc aggcatcagt agcccgtgtg      780

gttggacaac agggccgggg ccgggccggg attgaggcca gtctagatgt gcagtacctg      840

atgagtgctg gtgccaacat ctccacctgg gtctacagta gccctggccg gcatgaggga      900

caggagccct tcctgcagtg gctcatgctg ctcagtaatg agtcagccct gccacatgtg      960

catactgtga gctatggaga tgatgaggac tccctcagca gcgcctacat ccagcgggtc     1020

aacactgagc tcatgaaggc tgccgctcgg ggtctcaccc tgctcttcgc ctcaggtgac     1080

agtggggccg ggtgttggtc tgtctctgga agacaccagt tccgccctac cttccctgcc     1140

tccagcccct atgtcaccac agtgggaggc acatccttcc aggaaccttt cctcatcaca     1200

aatgaaattg ttgactatat cagtggtggt ggcttcagca atgtgttccc acggccttca     1260

taccaggagg aagctgtaac gaagttcctg agctctagcc cccacctgcc accatccagt     1320

tacttcaatg ccagtggccg tgcctaccca gatgtggctg cactttctga tggctactgg     1380

gtggtcagca acagagtgcc cattccatgg gtgtccggaa cctcggcctc tactccagtg     1440

tttgggggga tcctatcctt gatcaatgag cacaggatcc ttagtggccg cccccctctt     1500

ggctttctca acccaaggct ctaccagcag catggggcag gactctttga tgtaacccgt     1560

ggctgccatg agtcctgtct ggatgaagag gtagagggcc agggtttctg ctctggtcct     1620

ggctgggatc ctgtaacagg ctggggaaca cccaacttcc cagctttgct gaagactcta     1680

ctcaacccca gatccgtcga catcgaaggt agaggcattc ccgccttgcc cgaggatggc     1740

ggcagcggcg ccttcccgcc cggccacttc aaggacccca agcggctgta ctgcaaaaac     1800

gggggcttct tcctgcgcat ccaccccgac ggccgagttg acggggtccg ggagaagagc     1860

gaccctcaca tcaagctaca acttcaagca gaagagagag gagttgtgtc tatcaaagga     1920

gtgtctgcta accgttacct ggctatgaag gaagatggaa gattactggc ttctaaatct     1980

gttacggatg agtgtttctt ttttgaacga ttggaatcta ataactacaa tacttaccgg     2040

tcaaggaaat acaccagttg gtatgtggca ctgaaacgaa ctgggcagta taaacttggc     2100

tccaaaacag gacctgggca gaaagctata ctttttcttc caatgtctgc taagagctga     2160


<210>  36
<211>  719
<212>  PRT
<213>  Homo sapiens

<400>  36

Met Gly Leu Gln Ala Cys Leu Leu Gly Leu Phe Ala Leu Ile Leu Ser 
1               5                   10                  15      


Gly Lys Cys Ser Tyr Ser Pro Glu Pro Asp Gln Arg Arg Thr Leu Pro 
            20                  25                  30          


Pro Gly Trp Val Ser Leu Gly Arg Ala Asp Pro Glu Glu Glu Leu Ser 
        35                  40                  45              


Leu Thr Phe Ala Leu Arg Gln Gln Asn Val Glu Arg Leu Ser Glu Leu 
    50                  55                  60                  


Val Gln Ala Val Ser Asp Pro Ser Ser Pro Gln Tyr Gly Lys Tyr Leu 
65                  70                  75                  80  


Thr Leu Glu Asn Val Ala Asp Leu Val Arg Pro Ser Pro Leu Thr Leu 
                85                  90                  95      


His Thr Val Gln Lys Trp Leu Leu Ala Ala Gly Ala Gln Lys Cys His 
            100                 105                 110         


Ser Val Ile Thr Gln Asp Phe Leu Thr Cys Trp Leu Ser Ile Arg Gln 
        115                 120                 125             


Ala Glu Leu Leu Leu Pro Gly Ala Glu Phe His His Tyr Val Gly Gly 
    130                 135                 140                 


Pro Thr Glu Thr His Val Val Arg Ser Pro His Pro Tyr Gln Leu Pro 
145                 150                 155                 160 


Gln Ala Leu Ala Pro His Val Asp Phe Val Gly Gly Leu His Arg Phe 
                165                 170                 175     


Pro Pro Thr Ser Ser Leu Arg Gln Arg Pro Glu Pro Gln Val Thr Gly 
            180                 185                 190         


Thr Val Gly Leu His Leu Gly Val Thr Pro Ser Val Ile Arg Lys Arg 
        195                 200                 205             


Tyr Asn Leu Thr Ser Gln Asp Val Gly Ser Gly Thr Ser Asn Asn Ser 
    210                 215                 220                 


Gln Ala Cys Ala Gln Phe Leu Glu Gln Tyr Phe His Asp Ser Asp Leu 
225                 230                 235                 240 


Ala Gln Phe Met Arg Leu Phe Gly Gly Asn Phe Ala His Gln Ala Ser 
                245                 250                 255     


Val Ala Arg Val Val Gly Gln Gln Gly Arg Gly Arg Ala Gly Ile Glu 
            260                 265                 270         


Ala Ser Leu Asp Val Gln Tyr Leu Met Ser Ala Gly Ala Asn Ile Ser 
        275                 280                 285             


Thr Trp Val Tyr Ser Ser Pro Gly Arg His Glu Gly Gln Glu Pro Phe 
    290                 295                 300                 


Leu Gln Trp Leu Met Leu Leu Ser Asn Glu Ser Ala Leu Pro His Val 
305                 310                 315                 320 


His Thr Val Ser Tyr Gly Asp Asp Glu Asp Ser Leu Ser Ser Ala Tyr 
                325                 330                 335     


Ile Gln Arg Val Asn Thr Glu Leu Met Lys Ala Ala Ala Arg Gly Leu 
            340                 345                 350         


Thr Leu Leu Phe Ala Ser Gly Asp Ser Gly Ala Gly Cys Trp Ser Val 
        355                 360                 365             


Ser Gly Arg His Gln Phe Arg Pro Thr Phe Pro Ala Ser Ser Pro Tyr 
    370                 375                 380                 


Val Thr Thr Val Gly Gly Thr Ser Phe Gln Glu Pro Phe Leu Ile Thr 
385                 390                 395                 400 


Asn Glu Ile Val Asp Tyr Ile Ser Gly Gly Gly Phe Ser Asn Val Phe 
                405                 410                 415     


Pro Arg Pro Ser Tyr Gln Glu Glu Ala Val Thr Lys Phe Leu Ser Ser 
            420                 425                 430         


Ser Pro His Leu Pro Pro Ser Ser Tyr Phe Asn Ala Ser Gly Arg Ala 
        435                 440                 445             


Tyr Pro Asp Val Ala Ala Leu Ser Asp Gly Tyr Trp Val Val Ser Asn 
    450                 455                 460                 


Arg Val Pro Ile Pro Trp Val Ser Gly Thr Ser Ala Ser Thr Pro Val 
465                 470                 475                 480 


Phe Gly Gly Ile Leu Ser Leu Ile Asn Glu His Arg Ile Leu Ser Gly 
                485                 490                 495     


Arg Pro Pro Leu Gly Phe Leu Asn Pro Arg Leu Tyr Gln Gln His Gly 
            500                 505                 510         


Ala Gly Leu Phe Asp Val Thr Arg Gly Cys His Glu Ser Cys Leu Asp 
        515                 520                 525             


Glu Glu Val Glu Gly Gln Gly Phe Cys Ser Gly Pro Gly Trp Asp Pro 
    530                 535                 540                 


Val Thr Gly Trp Gly Thr Pro Asn Phe Pro Ala Leu Leu Lys Thr Leu 
545                 550                 555                 560 


Leu Asn Pro Arg Ser Val Asp Ile Glu Gly Arg Gly Ile Pro Ala Leu 
                565                 570                 575     


Pro Glu Asp Gly Gly Ser Gly Ala Phe Pro Pro Gly His Phe Lys Asp 
            580                 585                 590         


Pro Lys Arg Leu Tyr Cys Lys Asn Gly Gly Phe Phe Leu Arg Ile His 
        595                 600                 605             


Pro Asp Gly Arg Val Asp Gly Val Arg Glu Lys Ser Asp Pro His Ile 
    610                 615                 620                 


Lys Leu Gln Leu Gln Ala Glu Glu Arg Gly Val Val Ser Ile Lys Gly 
625                 630                 635                 640 


Val Ser Ala Asn Arg Tyr Leu Ala Met Lys Glu Asp Gly Arg Leu Leu 
                645                 650                 655     


Ala Ser Lys Ser Val Thr Asp Glu Cys Phe Phe Phe Glu Arg Leu Glu 
            660                 665                 670         


Ser Asn Asn Tyr Asn Thr Tyr Arg Ser Arg Lys Tyr Thr Ser Trp Tyr 
        675                 680                 685             


Val Ala Leu Lys Arg Thr Gly Gln Tyr Lys Leu Gly Ser Lys Thr Gly 
    690                 695                 700                 


Pro Gly Gln Lys Ala Ile Leu Phe Leu Pro Met Ser Ala Lys Ser 
705                 710                 715                 


<210>  37
<211>  2160
<212>  DNA
<213>  Homo sapiens

<400>  37
atgggactcc aagcctgcct cctagggctc tttgccctca tcctctctgg caaatgcagt       60

tacagcccgg agcccgacca gcggaggacg ctgcccccag gctgggtgtc cctgggccgt      120

gcggaccctg aggaagagct gagtctcacc tttgccctga gacagcagaa tgtggaaaga      180

ctctcggagc tggtgcaggc tgtgtcggat cccagctctc ctcaatacgg aaaatacctg      240

accctagaga atgtggctga tctggtgagg ccatccccac tgaccctcca cacggtgcaa      300

aaatggctct tggcagccgg agcccagaag tgccattctg tgatcacaca ggactttctg      360

acttgctggc tgagcatccg acaagcagag ctgctgctcc ctggggctga gtttcatcac      420

tatgtgggag gacctacgga aacccatgtt gtaaggtccc cacatcccta ccagcttcca      480

caggccttgg ccccccatgt ggactttgtg gggggactgc accgttttcc cccaacatca      540

tccctgaggc aacgtcctga gccgcaggtg acagggactg taggcctgca tctgggggta      600

accccctctg tgatccgtaa gcgatacaac ttgacctcac aagacgtggg ctctggcacc      660

agcaataaca gccaagcctg tgcccagttc ctggagcagt atttccatga ctcagacctg      720

gctcagttca tgcgcctctt cggtggcaac tttgcacatc aggcatcagt agcccgtgtg      780

gttggacaac agggccgggg ccgggccggg attgaggcca gtctagatgt gcagtacctg      840

atgagtgctg gtgccaacat ctccacctgg gtctacagta gccctggccg gcatgaggga      900

caggagccct tcctgcagtg gctcatgctg ctcagtaatg agtcagccct gccacatgtg      960

catactgtga gctatggaga tgatgaggac tccctcagca gcgcctacat ccagcgggtc     1020

aacactgagc tcatgaaggc tgccgctcgg ggtctcaccc tgctcttcgc ctcaggtgac     1080

agtggggccg ggtgttggtc tgtctctgga agacaccagt tccgccctac cttccctgcc     1140

tccagcccct atgtcaccac agtgggaggc acatccttcc aggaaccttt cctcatcaca     1200

aatgaaattg ttgactatat cagtggtggt ggcttcagca atgtgttccc acggccttca     1260

taccaggagg aagctgtaac gaagttcctg agctctagcc cccacctgcc accatccagt     1320

tacttcaatg ccagtggccg tgcctaccca gatgtggctg cactttctga tggctactgg     1380

gtggtcagca acagagtgcc cattccatgg gtgtccggaa cctcggcctc tactccagtg     1440

tttgggggga tcctatcctt gatcaatgag cacaggatcc ttagtggccg cccccctctt     1500

ggctttctca acccaaggct ctaccagcag catggggcag gactctttga tgtaacccgt     1560

ggctgccatg agtcctgtct ggatgaagag gtagagggcc agggtttctg ctctggtcct     1620

ggctgggatc ctgtaacagg ctggggaaca cccaacttcc cagctttgct gaagactcta     1680

ctcaacccca gatccgtcga catcgaaggt agaggcattc ccgccttgcc cgaggatggc     1740

ggcagcggcg ccttcccgcc cggccacttc aaggacccca agcggctgta ctgcaaaaac     1800

gggggcttct tcctgcgcat ccaccccgac ggccgagttg acggggtccg ggagaagagc     1860

gaccctcaca tcaagctaca acttcaagca gaagagagag gagttgtgtc tatcaaagga     1920

gtgtctgcta accgttacct ggctatgaag gaagatggaa gattactggc ttctaaatct     1980

gttacggatg agtgtttctt ttttgcacga ttggaatcta ataactacaa tacttaccgg     2040

tcaaggaaat acaccagttg gtatgtggca ctgaaacgaa ctgggcagta taaacttggc     2100

tccaaaacag gacctgggca gaaagctata ctttttcttc caatgtctgc taagagctga     2160


<210>  38
<211>  719
<212>  PRT
<213>  Homo sapiens

<400>  38

Met Gly Leu Gln Ala Cys Leu Leu Gly Leu Phe Ala Leu Ile Leu Ser 
1               5                   10                  15      


Gly Lys Cys Ser Tyr Ser Pro Glu Pro Asp Gln Arg Arg Thr Leu Pro 
            20                  25                  30          


Pro Gly Trp Val Ser Leu Gly Arg Ala Asp Pro Glu Glu Glu Leu Ser 
        35                  40                  45              


Leu Thr Phe Ala Leu Arg Gln Gln Asn Val Glu Arg Leu Ser Glu Leu 
    50                  55                  60                  


Val Gln Ala Val Ser Asp Pro Ser Ser Pro Gln Tyr Gly Lys Tyr Leu 
65                  70                  75                  80  


Thr Leu Glu Asn Val Ala Asp Leu Val Arg Pro Ser Pro Leu Thr Leu 
                85                  90                  95      


His Thr Val Gln Lys Trp Leu Leu Ala Ala Gly Ala Gln Lys Cys His 
            100                 105                 110         


Ser Val Ile Thr Gln Asp Phe Leu Thr Cys Trp Leu Ser Ile Arg Gln 
        115                 120                 125             


Ala Glu Leu Leu Leu Pro Gly Ala Glu Phe His His Tyr Val Gly Gly 
    130                 135                 140                 


Pro Thr Glu Thr His Val Val Arg Ser Pro His Pro Tyr Gln Leu Pro 
145                 150                 155                 160 


Gln Ala Leu Ala Pro His Val Asp Phe Val Gly Gly Leu His Arg Phe 
                165                 170                 175     


Pro Pro Thr Ser Ser Leu Arg Gln Arg Pro Glu Pro Gln Val Thr Gly 
            180                 185                 190         


Thr Val Gly Leu His Leu Gly Val Thr Pro Ser Val Ile Arg Lys Arg 
        195                 200                 205             


Tyr Asn Leu Thr Ser Gln Asp Val Gly Ser Gly Thr Ser Asn Asn Ser 
    210                 215                 220                 


Gln Ala Cys Ala Gln Phe Leu Glu Gln Tyr Phe His Asp Ser Asp Leu 
225                 230                 235                 240 


Ala Gln Phe Met Arg Leu Phe Gly Gly Asn Phe Ala His Gln Ala Ser 
                245                 250                 255     


Val Ala Arg Val Val Gly Gln Gln Gly Arg Gly Arg Ala Gly Ile Glu 
            260                 265                 270         


Ala Ser Leu Asp Val Gln Tyr Leu Met Ser Ala Gly Ala Asn Ile Ser 
        275                 280                 285             


Thr Trp Val Tyr Ser Ser Pro Gly Arg His Glu Gly Gln Glu Pro Phe 
    290                 295                 300                 


Leu Gln Trp Leu Met Leu Leu Ser Asn Glu Ser Ala Leu Pro His Val 
305                 310                 315                 320 


His Thr Val Ser Tyr Gly Asp Asp Glu Asp Ser Leu Ser Ser Ala Tyr 
                325                 330                 335     


Ile Gln Arg Val Asn Thr Glu Leu Met Lys Ala Ala Ala Arg Gly Leu 
            340                 345                 350         


Thr Leu Leu Phe Ala Ser Gly Asp Ser Gly Ala Gly Cys Trp Ser Val 
        355                 360                 365             


Ser Gly Arg His Gln Phe Arg Pro Thr Phe Pro Ala Ser Ser Pro Tyr 
    370                 375                 380                 


Val Thr Thr Val Gly Gly Thr Ser Phe Gln Glu Pro Phe Leu Ile Thr 
385                 390                 395                 400 


Asn Glu Ile Val Asp Tyr Ile Ser Gly Gly Gly Phe Ser Asn Val Phe 
                405                 410                 415     


Pro Arg Pro Ser Tyr Gln Glu Glu Ala Val Thr Lys Phe Leu Ser Ser 
            420                 425                 430         


Ser Pro His Leu Pro Pro Ser Ser Tyr Phe Asn Ala Ser Gly Arg Ala 
        435                 440                 445             


Tyr Pro Asp Val Ala Ala Leu Ser Asp Gly Tyr Trp Val Val Ser Asn 
    450                 455                 460                 


Arg Val Pro Ile Pro Trp Val Ser Gly Thr Ser Ala Ser Thr Pro Val 
465                 470                 475                 480 


Phe Gly Gly Ile Leu Ser Leu Ile Asn Glu His Arg Ile Leu Ser Gly 
                485                 490                 495     


Arg Pro Pro Leu Gly Phe Leu Asn Pro Arg Leu Tyr Gln Gln His Gly 
            500                 505                 510         


Ala Gly Leu Phe Asp Val Thr Arg Gly Cys His Glu Ser Cys Leu Asp 
        515                 520                 525             


Glu Glu Val Glu Gly Gln Gly Phe Cys Ser Gly Pro Gly Trp Asp Pro 
    530                 535                 540                 


Val Thr Gly Trp Gly Thr Pro Asn Phe Pro Ala Leu Leu Lys Thr Leu 
545                 550                 555                 560 


Leu Asn Pro Arg Ser Val Asp Ile Glu Gly Arg Gly Ile Pro Ala Leu 
                565                 570                 575     


Pro Glu Asp Gly Gly Ser Gly Ala Phe Pro Pro Gly His Phe Lys Asp 
            580                 585                 590         


Pro Lys Arg Leu Tyr Cys Lys Asn Gly Gly Phe Phe Leu Arg Ile His 
        595                 600                 605             


Pro Asp Gly Arg Val Asp Gly Val Arg Glu Lys Ser Asp Pro His Ile 
    610                 615                 620                 


Lys Leu Gln Leu Gln Ala Glu Glu Arg Gly Val Val Ser Ile Lys Gly 
625                 630                 635                 640 


Val Ser Ala Asn Arg Tyr Leu Ala Met Lys Glu Asp Gly Arg Leu Leu 
                645                 650                 655     


Ala Ser Lys Ser Val Thr Asp Glu Cys Phe Phe Phe Ala Arg Leu Glu 
            660                 665                 670         


Ser Asn Asn Tyr Asn Thr Tyr Arg Ser Arg Lys Tyr Thr Ser Trp Tyr 
        675                 680                 685             


Val Ala Leu Lys Arg Thr Gly Gln Tyr Lys Leu Gly Ser Lys Thr Gly 
    690                 695                 700                 


Pro Gly Gln Lys Ala Ile Leu Phe Leu Pro Met Ser Ala Lys Ser 
705                 710                 715                 


<210>  39
<211>  2160
<212>  DNA
<213>  Homo sapiens

<400>  39
atgggactcc aagcctgcct cctagggctc tttgccctca tcctctctgg caaatgcagt       60

tacagcccgg agcccgacca gcggaggacg ctgcccccag gctgggtgtc cctgggccgt      120

gcggaccctg aggaagagct gagtctcacc tttgccctga gacagcagaa tgtggaaaga      180

ctctcggagc tggtgcaggc tgtgtcggat cccagctctc ctcaatacgg aaaatacctg      240

accctagaga atgtggctga tctggtgagg ccatccccac tgaccctcca cacggtgcaa      300

aaatggctct tggcagccgg agcccagaag tgccattctg tgatcacaca ggactttctg      360

acttgctggc tgagcatccg acaagcagag ctgctgctcc ctggggctga gtttcatcac      420

tatgtgggag gacctacgga aacccatgtt gtaaggtccc cacatcccta ccagcttcca      480

caggccttgg ccccccatgt ggactttgtg gggggactgc accgttttcc cccaacatca      540

tccctgaggc aacgtcctga gccgcaggtg acagggactg taggcctgca tctgggggta      600

accccctctg tgatccgtaa gcgatacaac ttgacctcac aagacgtggg ctctggcacc      660

agcaataaca gccaagcctg tgcccagttc ctggagcagt atttccatga ctcagacctg      720

gctcagttca tgcgcctctt cggtggcaac tttgcacatc aggcatcagt agcccgtgtg      780

gttggacaac agggccgggg ccgggccggg attgaggcca gtctagatgt gcagtacctg      840

atgagtgctg gtgccaacat ctccacctgg gtctacagta gccctggccg gcatgaggga      900

caggagccct tcctgcagtg gctcatgctg ctcagtaatg agtcagccct gccacatgtg      960

catactgtga gctatggaga tgatgaggac tccctcagca gcgcctacat ccagcgggtc     1020

aacactgagc tcatgaaggc tgccgctcgg ggtctcaccc tgctcttcgc ctcaggtgac     1080

agtggggccg ggtgttggtc tgtctctgga agacaccagt tccgccctac cttccctgcc     1140

tccagcccct atgtcaccac agtgggaggc acatccttcc aggaaccttt cctcatcaca     1200

aatgaaattg ttgactatat cagtggtggt ggcttcagca atgtgttccc acggccttca     1260

taccaggagg aagctgtaac gaagttcctg agctctagcc cccacctgcc accatccagt     1320

tacttcaatg ccagtggccg tgcctaccca gatgtggctg cactttctga tggctactgg     1380

gtggtcagca acagagtgcc cattccatgg gtgtccggaa cctcggcctc tactccagtg     1440

tttgggggga tcctatcctt gatcaatgag cacaggatcc ttagtggccg cccccctctt     1500

ggctttctca acccaaggct ctaccagcag catggggcag gactctttga tgtaacccgt     1560

ggctgccatg agtcctgtct ggatgaagag gtagagggcc agggtttctg ctctggtcct     1620

ggctgggatc ctgtaacagg ctggggaaca cccaacttcc cagctttgct gaagactcta     1680

ctcaacccca gatccgtcga catcgaaggt agaggcattc ccgccttgcc cgaggatggc     1740

ggcagcggcg ccttcccgcc cggccacttc aaggacccca agcggctgta ctgcaaaaac     1800

gggggcttct tcctgcgcat ccaccccgac ggccgagttg acgggacaag ggacaggagc     1860

gaccagcaca ttcagctgca gctcagtgca gaagagagag gagttgtgtc tatcaaagga     1920

gtgtctgcta accgttacct ggctatgaag gaagatggaa gattactggc ttctaaatct     1980

gttacggatg agtgtttctt ttttgaacga ttggaatcta ataactacaa tacttaccgg     2040

tcaaggaaat acaccagttg gtatgtggca ctgaaacgaa ctgggcagta taaacttggc     2100

tccaaaacag gacctgggca gaaagctata ctttttcttc caatgtctgc taagagctga     2160


<210>  40
<211>  719
<212>  PRT
<213>  Homo sapiens

<400>  40

Met Gly Leu Gln Ala Cys Leu Leu Gly Leu Phe Ala Leu Ile Leu Ser 
1               5                   10                  15      


Gly Lys Cys Ser Tyr Ser Pro Glu Pro Asp Gln Arg Arg Thr Leu Pro 
            20                  25                  30          


Pro Gly Trp Val Ser Leu Gly Arg Ala Asp Pro Glu Glu Glu Leu Ser 
        35                  40                  45              


Leu Thr Phe Ala Leu Arg Gln Gln Asn Val Glu Arg Leu Ser Glu Leu 
    50                  55                  60                  


Val Gln Ala Val Ser Asp Pro Ser Ser Pro Gln Tyr Gly Lys Tyr Leu 
65                  70                  75                  80  


Thr Leu Glu Asn Val Ala Asp Leu Val Arg Pro Ser Pro Leu Thr Leu 
                85                  90                  95      


His Thr Val Gln Lys Trp Leu Leu Ala Ala Gly Ala Gln Lys Cys His 
            100                 105                 110         


Ser Val Ile Thr Gln Asp Phe Leu Thr Cys Trp Leu Ser Ile Arg Gln 
        115                 120                 125             


Ala Glu Leu Leu Leu Pro Gly Ala Glu Phe His His Tyr Val Gly Gly 
    130                 135                 140                 


Pro Thr Glu Thr His Val Val Arg Ser Pro His Pro Tyr Gln Leu Pro 
145                 150                 155                 160 


Gln Ala Leu Ala Pro His Val Asp Phe Val Gly Gly Leu His Arg Phe 
                165                 170                 175     


Pro Pro Thr Ser Ser Leu Arg Gln Arg Pro Glu Pro Gln Val Thr Gly 
            180                 185                 190         


Thr Val Gly Leu His Leu Gly Val Thr Pro Ser Val Ile Arg Lys Arg 
        195                 200                 205             


Tyr Asn Leu Thr Ser Gln Asp Val Gly Ser Gly Thr Ser Asn Asn Ser 
    210                 215                 220                 


Gln Ala Cys Ala Gln Phe Leu Glu Gln Tyr Phe His Asp Ser Asp Leu 
225                 230                 235                 240 


Ala Gln Phe Met Arg Leu Phe Gly Gly Asn Phe Ala His Gln Ala Ser 
                245                 250                 255     


Val Ala Arg Val Val Gly Gln Gln Gly Arg Gly Arg Ala Gly Ile Glu 
            260                 265                 270         


Ala Ser Leu Asp Val Gln Tyr Leu Met Ser Ala Gly Ala Asn Ile Ser 
        275                 280                 285             


Thr Trp Val Tyr Ser Ser Pro Gly Arg His Glu Gly Gln Glu Pro Phe 
    290                 295                 300                 


Leu Gln Trp Leu Met Leu Leu Ser Asn Glu Ser Ala Leu Pro His Val 
305                 310                 315                 320 


His Thr Val Ser Tyr Gly Asp Asp Glu Asp Ser Leu Ser Ser Ala Tyr 
                325                 330                 335     


Ile Gln Arg Val Asn Thr Glu Leu Met Lys Ala Ala Ala Arg Gly Leu 
            340                 345                 350         


Thr Leu Leu Phe Ala Ser Gly Asp Ser Gly Ala Gly Cys Trp Ser Val 
        355                 360                 365             


Ser Gly Arg His Gln Phe Arg Pro Thr Phe Pro Ala Ser Ser Pro Tyr 
    370                 375                 380                 


Val Thr Thr Val Gly Gly Thr Ser Phe Gln Glu Pro Phe Leu Ile Thr 
385                 390                 395                 400 


Asn Glu Ile Val Asp Tyr Ile Ser Gly Gly Gly Phe Ser Asn Val Phe 
                405                 410                 415     


Pro Arg Pro Ser Tyr Gln Glu Glu Ala Val Thr Lys Phe Leu Ser Ser 
            420                 425                 430         


Ser Pro His Leu Pro Pro Ser Ser Tyr Phe Asn Ala Ser Gly Arg Ala 
        435                 440                 445             


Tyr Pro Asp Val Ala Ala Leu Ser Asp Gly Tyr Trp Val Val Ser Asn 
    450                 455                 460                 


Arg Val Pro Ile Pro Trp Val Ser Gly Thr Ser Ala Ser Thr Pro Val 
465                 470                 475                 480 


Phe Gly Gly Ile Leu Ser Leu Ile Asn Glu His Arg Ile Leu Ser Gly 
                485                 490                 495     


Arg Pro Pro Leu Gly Phe Leu Asn Pro Arg Leu Tyr Gln Gln His Gly 
            500                 505                 510         


Ala Gly Leu Phe Asp Val Thr Arg Gly Cys His Glu Ser Cys Leu Asp 
        515                 520                 525             


Glu Glu Val Glu Gly Gln Gly Phe Cys Ser Gly Pro Gly Trp Asp Pro 
    530                 535                 540                 


Val Thr Gly Trp Gly Thr Pro Asn Phe Pro Ala Leu Leu Lys Thr Leu 
545                 550                 555                 560 


Leu Asn Pro Arg Ser Val Asp Ile Glu Gly Arg Gly Ile Pro Ala Leu 
                565                 570                 575     


Pro Glu Asp Gly Gly Ser Gly Ala Phe Pro Pro Gly His Phe Lys Asp 
            580                 585                 590         


Pro Lys Arg Leu Tyr Cys Lys Asn Gly Gly Phe Phe Leu Arg Ile His 
        595                 600                 605             


Pro Asp Gly Arg Val Asp Gly Thr Arg Asp Arg Ser Asp Gln His Ile 
    610                 615                 620                 


Gln Leu Gln Leu Ser Ala Glu Glu Arg Gly Val Val Ser Ile Lys Gly 
625                 630                 635                 640 


Val Ser Ala Asn Arg Tyr Leu Ala Met Lys Glu Asp Gly Arg Leu Leu 
                645                 650                 655     


Ala Ser Lys Ser Val Thr Asp Glu Cys Phe Phe Phe Glu Arg Leu Glu 
            660                 665                 670         


Ser Asn Asn Tyr Asn Thr Tyr Arg Ser Arg Lys Tyr Thr Ser Trp Tyr 
        675                 680                 685             


Val Ala Leu Lys Arg Thr Gly Gln Tyr Lys Leu Gly Ser Lys Thr Gly 
    690                 695                 700                 


Pro Gly Gln Lys Ala Ile Leu Phe Leu Pro Met Ser Ala Lys Ser 
705                 710                 715                 


<210>  41
<211>  2160
<212>  DNA
<213>  Homo sapiens

<400>  41
atgggactcc aagcctgcct cctagggctc tttgccctca tcctctctgg caaatgcagt       60

tacagcccgg agcccgacca gcggaggacg ctgcccccag gctgggtgtc cctgggccgt      120

gcggaccctg aggaagagct gagtctcacc tttgccctga gacagcagaa tgtggaaaga      180

ctctcggagc tggtgcaggc tgtgtcggat cccagctctc ctcaatacgg aaaatacctg      240

accctagaga atgtggctga tctggtgagg ccatccccac tgaccctcca cacggtgcaa      300

aaatggctct tggcagccgg agcccagaag tgccattctg tgatcacaca ggactttctg      360

acttgctggc tgagcatccg acaagcagag ctgctgctcc ctggggctga gtttcatcac      420

tatgtgggag gacctacgga aacccatgtt gtaaggtccc cacatcccta ccagcttcca      480

caggccttgg ccccccatgt ggactttgtg gggggactgc accgttttcc cccaacatca      540

tccctgaggc aacgtcctga gccgcaggtg acagggactg taggcctgca tctgggggta      600

accccctctg tgatccgtaa gcgatacaac ttgacctcac aagacgtggg ctctggcacc      660

agcaataaca gccaagcctg tgcccagttc ctggagcagt atttccatga ctcagacctg      720

gctcagttca tgcgcctctt cggtggcaac tttgcacatc aggcatcagt agcccgtgtg      780

gttggacaac agggccgggg ccgggccggg attgaggcca gtctagatgt gcagtacctg      840

atgagtgctg gtgccaacat ctccacctgg gtctacagta gccctggccg gcatgaggga      900

caggagccct tcctgcagtg gctcatgctg ctcagtaatg agtcagccct gccacatgtg      960

catactgtga gctatggaga tgatgaggac tccctcagca gcgcctacat ccagcgggtc     1020

aacactgagc tcatgaaggc tgccgctcgg ggtctcaccc tgctcttcgc ctcaggtgac     1080

agtggggccg ggtgttggtc tgtctctgga agacaccagt tccgccctac cttccctgcc     1140

tccagcccct atgtcaccac agtgggaggc acatccttcc aggaaccttt cctcatcaca     1200

aatgaaattg ttgactatat cagtggtggt ggcttcagca atgtgttccc acggccttca     1260

taccaggagg aagctgtaac gaagttcctg agctctagcc cccacctgcc accatccagt     1320

tacttcaatg ccagtggccg tgcctaccca gatgtggctg cactttctga tggctactgg     1380

gtggtcagca acagagtgcc cattccatgg gtgtccggaa cctcggcctc tactccagtg     1440

tttgggggga tcctatcctt gatcaatgag cacaggatcc ttagtggccg cccccctctt     1500

ggctttctca acccaaggct ctaccagcag catggggcag gactctttga tgtaacccgt     1560

ggctgccatg agtcctgtct ggatgaagag gtagagggcc agggtttctg ctctggtcct     1620

ggctgggatc ctgtaacagg ctggggaaca cccaacttcc cagctttgct gaagactcta     1680

ctcaacccca gatccgtcga catcgaaggt agaggcattc ccgccttgcc cgaggatggc     1740

ggcagcggcg ccttcccgcc cggccacttc aaggacccca agcggctgta ctgcaaaaac     1800

gggggcttct tcctgcgcat ccaccccgac ggccgagttg acgggacaag ggacaggagc     1860

gaccagcaca ttcagctgca gctcagtgca gaagagagag gagttgtgtc tatcaaagga     1920

gtgtctgcta accgttacct ggctatgaag gaagatggaa gattactggc ttctaaatct     1980

gttacggatg agtgtttctt ttttgcacga ttggaatcta ataactacaa tacttaccgg     2040

tcaaggaaat acaccagttg gtatgtggca ctgaaacgaa ctgggcagta taaacttggc     2100

tccaaaacag gacctgggca gaaagctata ctttttcttc caatgtctgc taagagctga     2160


<210>  42
<211>  719
<212>  PRT
<213>  Homo sapiens

<400>  42

Met Gly Leu Gln Ala Cys Leu Leu Gly Leu Phe Ala Leu Ile Leu Ser 
1               5                   10                  15      


Gly Lys Cys Ser Tyr Ser Pro Glu Pro Asp Gln Arg Arg Thr Leu Pro 
            20                  25                  30          


Pro Gly Trp Val Ser Leu Gly Arg Ala Asp Pro Glu Glu Glu Leu Ser 
        35                  40                  45              


Leu Thr Phe Ala Leu Arg Gln Gln Asn Val Glu Arg Leu Ser Glu Leu 
    50                  55                  60                  


Val Gln Ala Val Ser Asp Pro Ser Ser Pro Gln Tyr Gly Lys Tyr Leu 
65                  70                  75                  80  


Thr Leu Glu Asn Val Ala Asp Leu Val Arg Pro Ser Pro Leu Thr Leu 
                85                  90                  95      


His Thr Val Gln Lys Trp Leu Leu Ala Ala Gly Ala Gln Lys Cys His 
            100                 105                 110         


Ser Val Ile Thr Gln Asp Phe Leu Thr Cys Trp Leu Ser Ile Arg Gln 
        115                 120                 125             


Ala Glu Leu Leu Leu Pro Gly Ala Glu Phe His His Tyr Val Gly Gly 
    130                 135                 140                 


Pro Thr Glu Thr His Val Val Arg Ser Pro His Pro Tyr Gln Leu Pro 
145                 150                 155                 160 


Gln Ala Leu Ala Pro His Val Asp Phe Val Gly Gly Leu His Arg Phe 
                165                 170                 175     


Pro Pro Thr Ser Ser Leu Arg Gln Arg Pro Glu Pro Gln Val Thr Gly 
            180                 185                 190         


Thr Val Gly Leu His Leu Gly Val Thr Pro Ser Val Ile Arg Lys Arg 
        195                 200                 205             


Tyr Asn Leu Thr Ser Gln Asp Val Gly Ser Gly Thr Ser Asn Asn Ser 
    210                 215                 220                 


Gln Ala Cys Ala Gln Phe Leu Glu Gln Tyr Phe His Asp Ser Asp Leu 
225                 230                 235                 240 


Ala Gln Phe Met Arg Leu Phe Gly Gly Asn Phe Ala His Gln Ala Ser 
                245                 250                 255     


Val Ala Arg Val Val Gly Gln Gln Gly Arg Gly Arg Ala Gly Ile Glu 
            260                 265                 270         


Ala Ser Leu Asp Val Gln Tyr Leu Met Ser Ala Gly Ala Asn Ile Ser 
        275                 280                 285             


Thr Trp Val Tyr Ser Ser Pro Gly Arg His Glu Gly Gln Glu Pro Phe 
    290                 295                 300                 


Leu Gln Trp Leu Met Leu Leu Ser Asn Glu Ser Ala Leu Pro His Val 
305                 310                 315                 320 


His Thr Val Ser Tyr Gly Asp Asp Glu Asp Ser Leu Ser Ser Ala Tyr 
                325                 330                 335     


Ile Gln Arg Val Asn Thr Glu Leu Met Lys Ala Ala Ala Arg Gly Leu 
            340                 345                 350         


Thr Leu Leu Phe Ala Ser Gly Asp Ser Gly Ala Gly Cys Trp Ser Val 
        355                 360                 365             


Ser Gly Arg His Gln Phe Arg Pro Thr Phe Pro Ala Ser Ser Pro Tyr 
    370                 375                 380                 


Val Thr Thr Val Gly Gly Thr Ser Phe Gln Glu Pro Phe Leu Ile Thr 
385                 390                 395                 400 


Asn Glu Ile Val Asp Tyr Ile Ser Gly Gly Gly Phe Ser Asn Val Phe 
                405                 410                 415     


Pro Arg Pro Ser Tyr Gln Glu Glu Ala Val Thr Lys Phe Leu Ser Ser 
            420                 425                 430         


Ser Pro His Leu Pro Pro Ser Ser Tyr Phe Asn Ala Ser Gly Arg Ala 
        435                 440                 445             


Tyr Pro Asp Val Ala Ala Leu Ser Asp Gly Tyr Trp Val Val Ser Asn 
    450                 455                 460                 


Arg Val Pro Ile Pro Trp Val Ser Gly Thr Ser Ala Ser Thr Pro Val 
465                 470                 475                 480 


Phe Gly Gly Ile Leu Ser Leu Ile Asn Glu His Arg Ile Leu Ser Gly 
                485                 490                 495     


Arg Pro Pro Leu Gly Phe Leu Asn Pro Arg Leu Tyr Gln Gln His Gly 
            500                 505                 510         


Ala Gly Leu Phe Asp Val Thr Arg Gly Cys His Glu Ser Cys Leu Asp 
        515                 520                 525             


Glu Glu Val Glu Gly Gln Gly Phe Cys Ser Gly Pro Gly Trp Asp Pro 
    530                 535                 540                 


Val Thr Gly Trp Gly Thr Pro Asn Phe Pro Ala Leu Leu Lys Thr Leu 
545                 550                 555                 560 


Leu Asn Pro Arg Ser Val Asp Ile Glu Gly Arg Gly Ile Pro Ala Leu 
                565                 570                 575     


Pro Glu Asp Gly Gly Ser Gly Ala Phe Pro Pro Gly His Phe Lys Asp 
            580                 585                 590         


Pro Lys Arg Leu Tyr Cys Lys Asn Gly Gly Phe Phe Leu Arg Ile His 
        595                 600                 605             


Pro Asp Gly Arg Val Asp Gly Thr Arg Asp Arg Ser Asp Gln His Ile 
    610                 615                 620                 


Gln Leu Gln Leu Ser Ala Glu Glu Arg Gly Val Val Ser Ile Lys Gly 
625                 630                 635                 640 


Val Ser Ala Asn Arg Tyr Leu Ala Met Lys Glu Asp Gly Arg Leu Leu 
                645                 650                 655     


Ala Ser Lys Ser Val Thr Asp Glu Cys Phe Phe Phe Ala Arg Leu Glu 
            660                 665                 670         


Ser Asn Asn Tyr Asn Thr Tyr Arg Ser Arg Lys Tyr Thr Ser Trp Tyr 
        675                 680                 685             


Val Ala Leu Lys Arg Thr Gly Gln Tyr Lys Leu Gly Ser Lys Thr Gly 
    690                 695                 700                 


Pro Gly Gln Lys Ala Ile Leu Phe Leu Pro Met Ser Ala Lys Ser 
705                 710                 715                 


<210>  43
<211>  276
<212>  DNA
<213>  Homo sapiens

<400>  43
atgcagccct ccagccttct gccgctcgcc ctctgcctgc tggctgcacc cgccggatct       60

tccaagccac aagcactggc cacaccaaac aaggaggagc acgggaaaag aaagaagaaa      120

ggcaaggggc tagggaagaa gagggaccca tgtcttcgga aatacaagga cttctgcatc      180

catggagaat gcaaatatgt gaaggagctc cgggctccct cctgcatctg ccacccgggt      240

taccatggag agaggtgtca tgggctgagc ggatct                                276


<210>  44
<211>  141
<212>  DNA
<213>  Homo sapiens

<400>  44
atgcagccct ccagccttct gccgctcgcc ctctgcctgc tggctgcacc cgccggatct       60

gggaaaagaa agaagaaagg caaggggcta gggaagaaga gggacccatc tcttcggaaa      120

tacaaggact tctccggatc t                                                141


<210>  45
<211>  1725
<212>  DNA
<213>  Homo sapiens

<400>  45
atgcagccct ccagccttct gccgctcgcc ctctgcctgc tggctgcacc cgccggatct       60

tccaagccac aagcactggc cacaccaaac aaggaggagc acgggaaaag aaagaagaaa      120

ggcaaggggc tagggaagaa gagggaccca tgtcttcgga aatacaagga cttctgcatc      180

catggagaat gcaaatatgt gaaggagctc cgggctccct cctgcatctg ccacccgggt      240

taccatggag agaggtgtca tgggctgagc ggatctcgtc cccggaacgc actgctgctc      300

ctcgcggatg acggaggctt tgagagtggc gcgtacaaca acagcgccat cgccaccccg      360

cacctggacg ccttggcccg ccgcagcctc ctctttcgca atgccttcac ctcggtcagc      420

agctgctctc ccagccgcgc cagcctcctc actggcctgc cccagcatca gaatgggatg      480

tacgggctgc accaggacgt gcaccacttc aactccttcg acaaggtgcg gagcctgccg      540

ctgctgctca gccaagctgg tgtgcgcaca ggcatcatcg ggaagaagca cgtggggccg      600

gagaccgtgt acccgtttga ctttgcgtac acggaggaga atggctccgt cctccaggtg      660

gggcggaaca tcactagaat taagctgctc gtccggaaat tcctgcagac tcaggatgac      720

cggcctttct tcctctacgt cgccttccac gacccccacc gctgtgggca ctcccagccc      780

cagtacggaa ccttctgtga gaagtttggc aacggagaga gcggcatggg tcgtatccca      840

gactggaccc cccaggccta cgacccactg gacgtgctgg tgccttactt cgtccccaac      900

accccggcag cccgagccga cctggccgct cagtacacca ccgtaggccg catggaccaa      960

ggagttggac tggtgctcca ggagctgcgt gacgccggtg tcctgaacga cacactggtg     1020

atcttcacgt ccgacaacgg gatccccttc cccagcggca ggaccaacct gtactggccg     1080

ggcactgctg aacccttact ggtgtcatcc ccggagcacc caaaacgctg gggccaagtc     1140

agcgaggcct acgtgagcct cctagacctc acgcccacca tcttggattg gttctcgatc     1200

ccgtacccca gctacgccat ctttggctcg aagaccatcc acctcactgg ccggtccctc     1260

ctgccggcgc tggaggccga gcccctctgg gccaccgtct ttggcagcca gagccaccac     1320

gaggtcacca tgtcctaccc catgcgctcc gtgcagcacc ggcacttccg cctcgtgcac     1380

aacctcaact tcaagatgcc ctttcccatc gaccaggact tctacgtctc acccaccttc     1440

caggacctcc tgaaccgcac tacagctggt cagcccacgg gctggtacaa ggacctccgt     1500

cattactact accgggcgcg ctgggagctc tacgaccgga gccgggaccc ccacgagacc     1560

cagaacctgg ccaccgaccc gcgctttgct cagcttctgg agatgcttcg ggaccagctg     1620

gccaagtggc agtgggagac ccacgacccc tgggtgtgcg cccccgacgg cgtcctggag     1680

gagaagctct ctccccagtg ccagcccctc cacaatgagc tgtaa                     1725


<210>  46
<211>  574
<212>  PRT
<213>  Homo sapiens

<400>  46

Met Gln Pro Ser Ser Leu Leu Pro Leu Ala Leu Cys Leu Leu Ala Ala 
1               5                   10                  15      


Pro Ala Gly Ser Ser Lys Pro Gln Ala Leu Ala Thr Pro Asn Lys Glu 
            20                  25                  30          


Glu His Gly Lys Arg Lys Lys Lys Gly Lys Gly Leu Gly Lys Lys Arg 
        35                  40                  45              


Asp Pro Cys Leu Arg Lys Tyr Lys Asp Phe Cys Ile His Gly Glu Cys 
    50                  55                  60                  


Lys Tyr Val Lys Glu Leu Arg Ala Pro Ser Cys Ile Cys His Pro Gly 
65                  70                  75                  80  


Tyr His Gly Glu Arg Cys His Gly Leu Ser Gly Ser Arg Pro Arg Asn 
                85                  90                  95      


Ala Leu Leu Leu Leu Ala Asp Asp Gly Gly Phe Glu Ser Gly Ala Tyr 
            100                 105                 110         


Asn Asn Ser Ala Ile Ala Thr Pro His Leu Asp Ala Leu Ala Arg Arg 
        115                 120                 125             


Ser Leu Leu Phe Arg Asn Ala Phe Thr Ser Val Ser Ser Cys Ser Pro 
    130                 135                 140                 


Ser Arg Ala Ser Leu Leu Thr Gly Leu Pro Gln His Gln Asn Gly Met 
145                 150                 155                 160 


Tyr Gly Leu His Gln Asp Val His His Phe Asn Ser Phe Asp Lys Val 
                165                 170                 175     


Arg Ser Leu Pro Leu Leu Leu Ser Gln Ala Gly Val Arg Thr Gly Ile 
            180                 185                 190         


Ile Gly Lys Lys His Val Gly Pro Glu Thr Val Tyr Pro Phe Asp Phe 
        195                 200                 205             


Ala Tyr Thr Glu Glu Asn Gly Ser Val Leu Gln Val Gly Arg Asn Ile 
    210                 215                 220                 


Thr Arg Ile Lys Leu Leu Val Arg Lys Phe Leu Gln Thr Gln Asp Asp 
225                 230                 235                 240 


Arg Pro Phe Phe Leu Tyr Val Ala Phe His Asp Pro His Arg Cys Gly 
                245                 250                 255     


His Ser Gln Pro Gln Tyr Gly Thr Phe Cys Glu Lys Phe Gly Asn Gly 
            260                 265                 270         


Glu Ser Gly Met Gly Arg Ile Pro Asp Trp Thr Pro Gln Ala Tyr Asp 
        275                 280                 285             


Pro Leu Asp Val Leu Val Pro Tyr Phe Val Pro Asn Thr Pro Ala Ala 
    290                 295                 300                 


Arg Ala Asp Leu Ala Ala Gln Tyr Thr Thr Val Gly Arg Met Asp Gln 
305                 310                 315                 320 


Gly Val Gly Leu Val Leu Gln Glu Leu Arg Asp Ala Gly Val Leu Asn 
                325                 330                 335     


Asp Thr Leu Val Ile Phe Thr Ser Asp Asn Gly Ile Pro Phe Pro Ser 
            340                 345                 350         


Gly Arg Thr Asn Leu Tyr Trp Pro Gly Thr Ala Glu Pro Leu Leu Val 
        355                 360                 365             


Ser Ser Pro Glu His Pro Lys Arg Trp Gly Gln Val Ser Glu Ala Tyr 
    370                 375                 380                 


Val Ser Leu Leu Asp Leu Thr Pro Thr Ile Leu Asp Trp Phe Ser Ile 
385                 390                 395                 400 


Pro Tyr Pro Ser Tyr Ala Ile Phe Gly Ser Lys Thr Ile His Leu Thr 
                405                 410                 415     


Gly Arg Ser Leu Leu Pro Ala Leu Glu Ala Glu Pro Leu Trp Ala Thr 
            420                 425                 430         


Val Phe Gly Ser Gln Ser His His Glu Val Thr Met Ser Tyr Pro Met 
        435                 440                 445             


Arg Ser Val Gln His Arg His Phe Arg Leu Val His Asn Leu Asn Phe 
    450                 455                 460                 


Lys Met Pro Phe Pro Ile Asp Gln Asp Phe Tyr Val Ser Pro Thr Phe 
465                 470                 475                 480 


Gln Asp Leu Leu Asn Arg Thr Thr Ala Gly Gln Pro Thr Gly Trp Tyr 
                485                 490                 495     


Lys Asp Leu Arg His Tyr Tyr Tyr Arg Ala Arg Trp Glu Leu Tyr Asp 
            500                 505                 510         


Arg Ser Arg Asp Pro His Glu Thr Gln Asn Leu Ala Thr Asp Pro Arg 
        515                 520                 525             


Phe Ala Gln Leu Leu Glu Met Leu Arg Asp Gln Leu Ala Lys Trp Gln 
    530                 535                 540                 


Trp Glu Thr His Asp Pro Trp Val Cys Ala Pro Asp Gly Val Leu Glu 
545                 550                 555                 560 


Glu Lys Leu Ser Pro Gln Cys Gln Pro Leu His Asn Glu Leu 
                565                 570                 


<210>  47
<211>  1590
<212>  DNA
<213>  Homo sapiens

<400>  47
atgcagccct ccagccttct gccgctcgcc ctctgcctgc tggctgcacc cgccggatct       60

gggaaaagaa agaagaaagg caaggggcta gggaagaaga gggacccatc tcttcggaaa      120

tacaaggact tctccggatc tcgtccccgg aacgcactgc tgctcctcgc ggatgacgga      180

ggctttgaga gtggcgcgta caacaacagc gccatcgcca ccccgcacct ggacgccttg      240

gcccgccgca gcctcctctt tcgcaatgcc ttcacctcgg tcagcagctg ctctcccagc      300

cgcgccagcc tcctcactgg cctgccccag catcagaatg ggatgtacgg gctgcaccag      360

gacgtgcacc acttcaactc cttcgacaag gtgcggagcc tgccgctgct gctcagccaa      420

gctggtgtgc gcacaggcat catcgggaag aagcacgtgg ggccggagac cgtgtacccg      480

tttgactttg cgtacacgga ggagaatggc tccgtcctcc aggtggggcg gaacatcact      540

agaattaagc tgctcgtccg gaaattcctg cagactcagg atgaccggcc tttcttcctc      600

tacgtcgcct tccacgaccc ccaccgctgt gggcactccc agccccagta cggaaccttc      660

tgtgagaagt ttggcaacgg agagagcggc atgggtcgta tcccagactg gaccccccag      720

gcctacgacc cactggacgt gctggtgcct tacttcgtcc ccaacacccc ggcagcccga      780

gccgacctgg ccgctcagta caccaccgta ggccgcatgg accaaggagt tggactggtg      840

ctccaggagc tgcgtgacgc cggtgtcctg aacgacacac tggtgatctt cacgtccgac      900

aacgggatcc ccttccccag cggcaggacc aacctgtact ggccgggcac tgctgaaccc      960

ttactggtgt catccccgga gcacccaaaa cgctggggcc aagtcagcga ggcctacgtg     1020

agcctcctag acctcacgcc caccatcttg gattggttct cgatcccgta ccccagctac     1080

gccatctttg gctcgaagac catccacctc actggccggt ccctcctgcc ggcgctggag     1140

gccgagcccc tctgggccac cgtctttggc agccagagcc accacgaggt caccatgtcc     1200

taccccatgc gctccgtgca gcaccggcac ttccgcctcg tgcacaacct caacttcaag     1260

atgccctttc ccatcgacca ggacttctac gtctcaccca ccttccagga cctcctgaac     1320

cgcactacag ctggtcagcc cacgggctgg tacaaggacc tccgtcatta ctactaccgg     1380

gcgcgctggg agctctacga ccggagccgg gacccccacg agacccagaa cctggccacc     1440

gacccgcgct ttgctcagct tctggagatg cttcgggacc agctggccaa gtggcagtgg     1500

gagacccacg acccctgggt gtgcgccccc gacggcgtcc tggaggagaa gctctctccc     1560

cagtgccagc ccctccacaa tgagctgtaa                                      1590


<210>  48
<211>  529
<212>  PRT
<213>  Homo sapiens

<400>  48

Met Gln Pro Ser Ser Leu Leu Pro Leu Ala Leu Cys Leu Leu Ala Ala 
1               5                   10                  15      


Pro Ala Gly Ser Gly Lys Arg Lys Lys Lys Gly Lys Gly Leu Gly Lys 
            20                  25                  30          


Lys Arg Asp Pro Ser Leu Arg Lys Tyr Lys Asp Phe Ser Gly Ser Arg 
        35                  40                  45              


Pro Arg Asn Ala Leu Leu Leu Leu Ala Asp Asp Gly Gly Phe Glu Ser 
    50                  55                  60                  


Gly Ala Tyr Asn Asn Ser Ala Ile Ala Thr Pro His Leu Asp Ala Leu 
65                  70                  75                  80  


Ala Arg Arg Ser Leu Leu Phe Arg Asn Ala Phe Thr Ser Val Ser Ser 
                85                  90                  95      


Cys Ser Pro Ser Arg Ala Ser Leu Leu Thr Gly Leu Pro Gln His Gln 
            100                 105                 110         


Asn Gly Met Tyr Gly Leu His Gln Asp Val His His Phe Asn Ser Phe 
        115                 120                 125             


Asp Lys Val Arg Ser Leu Pro Leu Leu Leu Ser Gln Ala Gly Val Arg 
    130                 135                 140                 


Thr Gly Ile Ile Gly Lys Lys His Val Gly Pro Glu Thr Val Tyr Pro 
145                 150                 155                 160 


Phe Asp Phe Ala Tyr Thr Glu Glu Asn Gly Ser Val Leu Gln Val Gly 
                165                 170                 175     


Arg Asn Ile Thr Arg Ile Lys Leu Leu Val Arg Lys Phe Leu Gln Thr 
            180                 185                 190         


Gln Asp Asp Arg Pro Phe Phe Leu Tyr Val Ala Phe His Asp Pro His 
        195                 200                 205             


Arg Cys Gly His Ser Gln Pro Gln Tyr Gly Thr Phe Cys Glu Lys Phe 
    210                 215                 220                 


Gly Asn Gly Glu Ser Gly Met Gly Arg Ile Pro Asp Trp Thr Pro Gln 
225                 230                 235                 240 


Ala Tyr Asp Pro Leu Asp Val Leu Val Pro Tyr Phe Val Pro Asn Thr 
                245                 250                 255     


Pro Ala Ala Arg Ala Asp Leu Ala Ala Gln Tyr Thr Thr Val Gly Arg 
            260                 265                 270         


Met Asp Gln Gly Val Gly Leu Val Leu Gln Glu Leu Arg Asp Ala Gly 
        275                 280                 285             


Val Leu Asn Asp Thr Leu Val Ile Phe Thr Ser Asp Asn Gly Ile Pro 
    290                 295                 300                 


Phe Pro Ser Gly Arg Thr Asn Leu Tyr Trp Pro Gly Thr Ala Glu Pro 
305                 310                 315                 320 


Leu Leu Val Ser Ser Pro Glu His Pro Lys Arg Trp Gly Gln Val Ser 
                325                 330                 335     


Glu Ala Tyr Val Ser Leu Leu Asp Leu Thr Pro Thr Ile Leu Asp Trp 
            340                 345                 350         


Phe Ser Ile Pro Tyr Pro Ser Tyr Ala Ile Phe Gly Ser Lys Thr Ile 
        355                 360                 365             


His Leu Thr Gly Arg Ser Leu Leu Pro Ala Leu Glu Ala Glu Pro Leu 
    370                 375                 380                 


Trp Ala Thr Val Phe Gly Ser Gln Ser His His Glu Val Thr Met Ser 
385                 390                 395                 400 


Tyr Pro Met Arg Ser Val Gln His Arg His Phe Arg Leu Val His Asn 
                405                 410                 415     


Leu Asn Phe Lys Met Pro Phe Pro Ile Asp Gln Asp Phe Tyr Val Ser 
            420                 425                 430         


Pro Thr Phe Gln Asp Leu Leu Asn Arg Thr Thr Ala Gly Gln Pro Thr 
        435                 440                 445             


Gly Trp Tyr Lys Asp Leu Arg His Tyr Tyr Tyr Arg Ala Arg Trp Glu 
    450                 455                 460                 


Leu Tyr Asp Arg Ser Arg Asp Pro His Glu Thr Gln Asn Leu Ala Thr 
465                 470                 475                 480 


Asp Pro Arg Phe Ala Gln Leu Leu Glu Met Leu Arg Asp Gln Leu Ala 
                485                 490                 495     


Lys Trp Gln Trp Glu Thr His Asp Pro Trp Val Cys Ala Pro Asp Gly 
            500                 505                 510         


Val Leu Glu Glu Lys Leu Ser Pro Gln Cys Gln Pro Leu His Asn Glu 
        515                 520                 525             


Leu 
    


<210>  49
<211>  1650
<212>  DNA
<213>  Homo sapiens

<400>  49
atgcagccct ccagccttct gccgctcgcc ctctgcctgc tggctgcacc cgccggatct       60

gggaaaagaa agaagaaagg caaggggcta gggaagaaga gggacccatc tcttcggaaa      120

tacaaggact tctccggatc tcgtccccgg aacgcactgc tgctcctcgc ggatgacgga      180

ggctttgaga gtggcgcgta caacaacagc gccatcgcca ccccgcacct ggacgccttg      240

gcccgccgca gcctcctctt tcgcaatgcc ttcacctcgg tcagcagctg ctctcccagc      300

cgcgccagcc tcctcactgg cctgccccag catcagaatg ggatgtacgg gctgcaccag      360

gacgtgcacc acttcaactc cttcgacaag gtgcggagcc tgccgctgct gctcagccaa      420

gctggtgtgc gcacaggcat catcgggaag aagcacgtgg ggccggagac cgtgtacccg      480

tttgactttg cgtacacgga ggagaatggc tccgtcctcc aggtggggcg gaacatcact      540

agaattaagc tgctcgtccg gaaattcctg cagactcagg atgaccggcc tttcttcctc      600

tacgtcgcct tccacgaccc ccaccgctgt gggcactccc agccccagta cggaaccttc      660

tgtgagaagt ttggcaacgg agagagcggc atgggtcgta tcccagactg gaccccccag      720

gcctacgacc cactggacgt gctggtgcct tacttcgtcc ccaacacccc ggcagcccga      780

gccgacctgg ccgctcagta caccaccgta ggccgcatgg accaaggagt tggactggtg      840

ctccaggagc tgcgtgacgc cggtgtcctg aacgacacac tggtgatctt cacgtccgac      900

aacgggatcc ccttccccag cggcaggacc aacctgtact ggccgggcac tgctgaaccc      960

ttactggtgt catccccgga gcacccaaaa cgctggggcc aagtcagcga ggcctacgtg     1020

agcctcctag acctcacgcc caccatcttg gattggttct cgatcccgta ccccagctac     1080

gccatctttg gctcgaagac catccacctc actggccggt ccctcctgcc ggcgctggag     1140

gccgagcccc tctgggccac cgtctttggc agccagagcc accacgaggt caccatgtcc     1200

taccccatgc gctccgtgca gcaccggcac ttccgcctcg tgcacaacct caacttcaag     1260

atgccctttc ccatcgacca ggacttctac gtctcaccca ccttccagga cctcctgaac     1320

cgcactacag ctggtcagcc cacgggctgg tacaaggacc tccgtcatta ctactaccgg     1380

gcgcgctggg agctctacga ccggagccgg gacccccacg agacccagaa cctggccacc     1440

gacccgcgct ttgctcagct tctggagatg cttcgggacc agctggccaa gtggcagtgg     1500

gagacccacg acccctgggt gtgcgccccc gacggcgtcc tggaggagaa gctctctccc     1560

cagtgccagc ccctccacaa tgagctgaga tcccccgggc gccagataaa gatttggttc     1620

cagaatcggc gcatgaagtg gaagaagtaa                                      1650


<210>  50
<211>  549
<212>  PRT
<213>  Homo sapiens

<400>  50

Met Gln Pro Ser Ser Leu Leu Pro Leu Ala Leu Cys Leu Leu Ala Ala 
1               5                   10                  15      


Pro Ala Gly Ser Gly Lys Arg Lys Lys Lys Gly Lys Gly Leu Gly Lys 
            20                  25                  30          


Lys Arg Asp Pro Ser Leu Arg Lys Tyr Lys Asp Phe Ser Gly Ser Arg 
        35                  40                  45              


Pro Arg Asn Ala Leu Leu Leu Leu Ala Asp Asp Gly Gly Phe Glu Ser 
    50                  55                  60                  


Gly Ala Tyr Asn Asn Ser Ala Ile Ala Thr Pro His Leu Asp Ala Leu 
65                  70                  75                  80  


Ala Arg Arg Ser Leu Leu Phe Arg Asn Ala Phe Thr Ser Val Ser Ser 
                85                  90                  95      


Cys Ser Pro Ser Arg Ala Ser Leu Leu Thr Gly Leu Pro Gln His Gln 
            100                 105                 110         


Asn Gly Met Tyr Gly Leu His Gln Asp Val His His Phe Asn Ser Phe 
        115                 120                 125             


Asp Lys Val Arg Ser Leu Pro Leu Leu Leu Ser Gln Ala Gly Val Arg 
    130                 135                 140                 


Thr Gly Ile Ile Gly Lys Lys His Val Gly Pro Glu Thr Val Tyr Pro 
145                 150                 155                 160 


Phe Asp Phe Ala Tyr Thr Glu Glu Asn Gly Ser Val Leu Gln Val Gly 
                165                 170                 175     


Arg Asn Ile Thr Arg Ile Lys Leu Leu Val Arg Lys Phe Leu Gln Thr 
            180                 185                 190         


Gln Asp Asp Arg Pro Phe Phe Leu Tyr Val Ala Phe His Asp Pro His 
        195                 200                 205             


Arg Cys Gly His Ser Gln Pro Gln Tyr Gly Thr Phe Cys Glu Lys Phe 
    210                 215                 220                 


Gly Asn Gly Glu Ser Gly Met Gly Arg Ile Pro Asp Trp Thr Pro Gln 
225                 230                 235                 240 


Ala Tyr Asp Pro Leu Asp Val Leu Val Pro Tyr Phe Val Pro Asn Thr 
                245                 250                 255     


Pro Ala Ala Arg Ala Asp Leu Ala Ala Gln Tyr Thr Thr Val Gly Arg 
            260                 265                 270         


Met Asp Gln Gly Val Gly Leu Val Leu Gln Glu Leu Arg Asp Ala Gly 
        275                 280                 285             


Val Leu Asn Asp Thr Leu Val Ile Phe Thr Ser Asp Asn Gly Ile Pro 
    290                 295                 300                 


Phe Pro Ser Gly Arg Thr Asn Leu Tyr Trp Pro Gly Thr Ala Glu Pro 
305                 310                 315                 320 


Leu Leu Val Ser Ser Pro Glu His Pro Lys Arg Trp Gly Gln Val Ser 
                325                 330                 335     


Glu Ala Tyr Val Ser Leu Leu Asp Leu Thr Pro Thr Ile Leu Asp Trp 
            340                 345                 350         


Phe Ser Ile Pro Tyr Pro Ser Tyr Ala Ile Phe Gly Ser Lys Thr Ile 
        355                 360                 365             


His Leu Thr Gly Arg Ser Leu Leu Pro Ala Leu Glu Ala Glu Pro Leu 
    370                 375                 380                 


Trp Ala Thr Val Phe Gly Ser Gln Ser His His Glu Val Thr Met Ser 
385                 390                 395                 400 


Tyr Pro Met Arg Ser Val Gln His Arg His Phe Arg Leu Val His Asn 
                405                 410                 415     


Leu Asn Phe Lys Met Pro Phe Pro Ile Asp Gln Asp Phe Tyr Val Ser 
            420                 425                 430         


Pro Thr Phe Gln Asp Leu Leu Asn Arg Thr Thr Ala Gly Gln Pro Thr 
        435                 440                 445             


Gly Trp Tyr Lys Asp Leu Arg His Tyr Tyr Tyr Arg Ala Arg Trp Glu 
    450                 455                 460                 


Leu Tyr Asp Arg Ser Arg Asp Pro His Glu Thr Gln Asn Leu Ala Thr 
465                 470                 475                 480 


Asp Pro Arg Phe Ala Gln Leu Leu Glu Met Leu Arg Asp Gln Leu Ala 
                485                 490                 495     


Lys Trp Gln Trp Glu Thr His Asp Pro Trp Val Cys Ala Pro Asp Gly 
            500                 505                 510         


Val Leu Glu Glu Lys Leu Ser Pro Gln Cys Gln Pro Leu His Asn Glu 
        515                 520                 525             


Leu Arg Ser Pro Gly Arg Gln Ile Lys Ile Trp Phe Gln Asn Arg Arg 
    530                 535                 540                 


Met Lys Trp Lys Lys 
545                 


<210>  51
<211>  1692
<212>  DNA
<213>  Homo sapiens

<400>  51
atgggactcc aagcctgcct cctagggctc tttgccctca tcctctctgg caaatgcagt       60

tacagcccgg agcccgacca gcggaggacg ctgcccccag gctgggtgtc cctgggccgt      120

gcggaccctg aggaagagct gagtctcacc tttgccctga gacagcagaa tgtggaaaga      180

ctctcggagc tggtgcaggc tgtgtcggat cccagctctc ctcaatacgg aaaatacctg      240

accctagaga atgtggctga tctggtgagg ccatccccac tgaccctcca cacggtgcaa      300

aaatggctct tggcagccgg agcccagaag tgccattctg tgatcacaca ggactttctg      360

acttgctggc tgagcatccg acaagcagag ctgctgctcc ctggggctga gtttcatcac      420

tatgtgggag gacctacgga aacccatgtt gtaaggtccc cacatcccta ccagcttcca      480

caggccttgg ccccccatgt ggactttgtg gggggactgc accgttttcc cccaacatca      540

tccctgaggc aacgtcctga gccgcaggtg acagggactg taggcctgca tctgggggta      600

accccctctg tgatccgtaa gcgatacaac ttgacctcac aagacgtggg ctctggcacc      660

agcaataaca gccaagcctg tgcccagttc ctggagcagt atttccatga ctcagacctg      720

gctcagttca tgcgcctctt cggtggcaac tttgcacatc aggcatcagt agcccgtgtg      780

gttggacaac agggccgggg ccgggccggg attgaggcca gtctagatgt gcagtacctg      840

atgagtgctg gtgccaacat ctccacctgg gtctacagta gccctggccg gcatgaggga      900

caggagccct tcctgcagtg gctcatgctg ctcagtaatg agtcagccct gccacatgtg      960

catactgtga gctatggaga tgatgaggac tccctcagca gcgcctacat ccagcgggtc     1020

aacactgagc tcatgaaggc tgccgctcgg ggtctcaccc tgctcttcgc ctcaggtgac     1080

agtggggccg ggtgttggtc tgtctctgga agacaccagt tccgccctac cttccctgcc     1140

tccagcccct atgtcaccac agtgggaggc acatccttcc aggaaccttt cctcatcaca     1200

aatgaaattg ttgactatat cagtggtggt ggcttcagca atgtgttccc acggccttca     1260

taccaggagg aagctgtaac gaagttcctg agctctagcc cccacctgcc accatccagt     1320

tacttcaatg ccagtggccg tgcctaccca gatgtggctg cactttctga tggctactgg     1380

gtggtcagca acagagtgcc cattccatgg gtgtccggaa cctcggcctc tactccagtg     1440

tttgggggga tcctatcctt gatcaatgag cacaggatcc ttagtggccg cccccctctt     1500

ggctttctca acccaaggct ctaccagcag catggggcag gactctttga tgtaacccgt     1560

ggctgccatg agtcctgtct ggatgaagag gtagagggcc agggtttctg ctctggtcct     1620

ggctgggatc ctgtaacagg ctggggaaca cccaacttcc cagctttgct gaagactcta     1680

ctcaacccct ga                                                         1692


<210>  52
<211>  563
<212>  PRT
<213>  Homo sapiens

<400>  52

Met Gly Leu Gln Ala Cys Leu Leu Gly Leu Phe Ala Leu Ile Leu Ser 
1               5                   10                  15      


Gly Lys Cys Ser Tyr Ser Pro Glu Pro Asp Gln Arg Arg Thr Leu Pro 
            20                  25                  30          


Pro Gly Trp Val Ser Leu Gly Arg Ala Asp Pro Glu Glu Glu Leu Ser 
        35                  40                  45              


Leu Thr Phe Ala Leu Arg Gln Gln Asn Val Glu Arg Leu Ser Glu Leu 
    50                  55                  60                  


Val Gln Ala Val Ser Asp Pro Ser Ser Pro Gln Tyr Gly Lys Tyr Leu 
65                  70                  75                  80  


Thr Leu Glu Asn Val Ala Asp Leu Val Arg Pro Ser Pro Leu Thr Leu 
                85                  90                  95      


His Thr Val Gln Lys Trp Leu Leu Ala Ala Gly Ala Gln Lys Cys His 
            100                 105                 110         


Ser Val Ile Thr Gln Asp Phe Leu Thr Cys Trp Leu Ser Ile Arg Gln 
        115                 120                 125             


Ala Glu Leu Leu Leu Pro Gly Ala Glu Phe His His Tyr Val Gly Gly 
    130                 135                 140                 


Pro Thr Glu Thr His Val Val Arg Ser Pro His Pro Tyr Gln Leu Pro 
145                 150                 155                 160 


Gln Ala Leu Ala Pro His Val Asp Phe Val Gly Gly Leu His Arg Phe 
                165                 170                 175     


Pro Pro Thr Ser Ser Leu Arg Gln Arg Pro Glu Pro Gln Val Thr Gly 
            180                 185                 190         


Thr Val Gly Leu His Leu Gly Val Thr Pro Ser Val Ile Arg Lys Arg 
        195                 200                 205             


Tyr Asn Leu Thr Ser Gln Asp Val Gly Ser Gly Thr Ser Asn Asn Ser 
    210                 215                 220                 


Gln Ala Cys Ala Gln Phe Leu Glu Gln Tyr Phe His Asp Ser Asp Leu 
225                 230                 235                 240 


Ala Gln Phe Met Arg Leu Phe Gly Gly Asn Phe Ala His Gln Ala Ser 
                245                 250                 255     


Val Ala Arg Val Val Gly Gln Gln Gly Arg Gly Arg Ala Gly Ile Glu 
            260                 265                 270         


Ala Ser Leu Asp Val Gln Tyr Leu Met Ser Ala Gly Ala Asn Ile Ser 
        275                 280                 285             


Thr Trp Val Tyr Ser Ser Pro Gly Arg His Glu Gly Gln Glu Pro Phe 
    290                 295                 300                 


Leu Gln Trp Leu Met Leu Leu Ser Asn Glu Ser Ala Leu Pro His Val 
305                 310                 315                 320 


His Thr Val Ser Tyr Gly Asp Asp Glu Asp Ser Leu Ser Ser Ala Tyr 
                325                 330                 335     


Ile Gln Arg Val Asn Thr Glu Leu Met Lys Ala Ala Ala Arg Gly Leu 
            340                 345                 350         


Thr Leu Leu Phe Ala Ser Gly Asp Ser Gly Ala Gly Cys Trp Ser Val 
        355                 360                 365             


Ser Gly Arg His Gln Phe Arg Pro Thr Phe Pro Ala Ser Ser Pro Tyr 
    370                 375                 380                 


Val Thr Thr Val Gly Gly Thr Ser Phe Gln Glu Pro Phe Leu Ile Thr 
385                 390                 395                 400 


Asn Glu Ile Val Asp Tyr Ile Ser Gly Gly Gly Phe Ser Asn Val Phe 
                405                 410                 415     


Pro Arg Pro Ser Tyr Gln Glu Glu Ala Val Thr Lys Phe Leu Ser Ser 
            420                 425                 430         


Ser Pro His Leu Pro Pro Ser Ser Tyr Phe Asn Ala Ser Gly Arg Ala 
        435                 440                 445             


Tyr Pro Asp Val Ala Ala Leu Ser Asp Gly Tyr Trp Val Val Ser Asn 
    450                 455                 460                 


Arg Val Pro Ile Pro Trp Val Ser Gly Thr Ser Ala Ser Thr Pro Val 
465                 470                 475                 480 


Phe Gly Gly Ile Leu Ser Leu Ile Asn Glu His Arg Ile Leu Ser Gly 
                485                 490                 495     


Arg Pro Pro Leu Gly Phe Leu Asn Pro Arg Leu Tyr Gln Gln His Gly 
            500                 505                 510         


Ala Gly Leu Phe Asp Val Thr Arg Gly Cys His Glu Ser Cys Leu Asp 
        515                 520                 525             


Glu Glu Val Glu Gly Gln Gly Phe Cys Ser Gly Pro Gly Trp Asp Pro 
    530                 535                 540                 


Val Thr Gly Trp Gly Thr Pro Asn Phe Pro Ala Leu Leu Lys Thr Leu 
545                 550                 555                 560 


Leu Asn Pro 
            


<210>  53
<211>  1239
<212>  DNA
<213>  Homo sapiens

<400>  53
atgcagccct ccagccttct gccgctcgcc ctctgcctgc tggctgcacc cgcctccgcg       60

ctcgtcagga tcccgctgca caagttcacg tccatccgcc ggaccatgtc ggaggttggg      120

ggctctgtgg aggacctgat tgccaaaggc cccgtctcaa agtactccca ggcggtgcca      180

gccgtgaccg aggggcccat tcccgaggtg ctcaagaact acatggacgc ccagtactac      240

ggggagattg gcatcgggac gcccccccag tgcttcacag tcgtcttcga cacgggctcc      300

tccaacctgt gggtcccctc catccactgc aaactgctgg acatcgcttg ctggatccac      360

cacaagtaca acagcgacaa gtccagcacc tacgtgaaga atggtacctc gtttgacatc      420

cactatggct cgggcagcct ctccgggtac ctgagccagg acactgtgtc ggtgccctgc      480

cagtcagcgt cgtcagcctc tgccctgggc ggtgtcaaag tggagaggca ggtctttggg      540

gaggccacca agcagccagg catcaccttc atcgcagcca agttcgatgg catcctgggc      600

atggcctacc cccgcatctc cgtcaacaac gtgctgcccg tcttcgacaa cctgatgcag      660

cagaagctgg tggaccagaa catcttctcc ttctacctga gcagggaccc agatgcgcag      720

cctgggggtg agctgatgct gggtggcaca gactccaagt attacaaggg ttctctgtcc      780

tacctgaatg tcacccgcaa ggcctactgg caggtccacc tggaccaggt ggaggtggcc      840

agcgggctga ccctgtgcaa ggagggctgt gaggccattg tggacacagg cacttccctc      900

atggtgggcc cggtggatga ggtgcgcgag ctgcagaagg ccatcggggc cgtgccgctg      960

attcagggcg agtacatgat cccctgtgag aaggtgtcca ccctgcccgc gatcacactg     1020

aagctgggag gcaaaggcta caagctgtcc ccagaggact acacgctcaa ggtgtcgcag     1080

gccgggaaga ccctctgcct gagcggcttc atgggcatgg acatcccgcc acccagcggg     1140

ccactctgga tcctgggcga cgtcttcatc ggccgctact acactgtgtt tgaccgtgac     1200

aacaacaggg tgggcttcgc cgaggctgcc cgcctctag                            1239


<210>  54
<211>  412
<212>  PRT
<213>  Homo sapiens

<400>  54

Met Gln Pro Ser Ser Leu Leu Pro Leu Ala Leu Cys Leu Leu Ala Ala 
1               5                   10                  15      


Pro Ala Ser Ala Leu Val Arg Ile Pro Leu His Lys Phe Thr Ser Ile 
            20                  25                  30          


Arg Arg Thr Met Ser Glu Val Gly Gly Ser Val Glu Asp Leu Ile Ala 
        35                  40                  45              


Lys Gly Pro Val Ser Lys Tyr Ser Gln Ala Val Pro Ala Val Thr Glu 
    50                  55                  60                  


Gly Pro Ile Pro Glu Val Leu Lys Asn Tyr Met Asp Ala Gln Tyr Tyr 
65                  70                  75                  80  


Gly Glu Ile Gly Ile Gly Thr Pro Pro Gln Cys Phe Thr Val Val Phe 
                85                  90                  95      


Asp Thr Gly Ser Ser Asn Leu Trp Val Pro Ser Ile His Cys Lys Leu 
            100                 105                 110         


Leu Asp Ile Ala Cys Trp Ile His His Lys Tyr Asn Ser Asp Lys Ser 
        115                 120                 125             


Ser Thr Tyr Val Lys Asn Gly Thr Ser Phe Asp Ile His Tyr Gly Ser 
    130                 135                 140                 


Gly Ser Leu Ser Gly Tyr Leu Ser Gln Asp Thr Val Ser Val Pro Cys 
145                 150                 155                 160 


Gln Ser Ala Ser Ser Ala Ser Ala Leu Gly Gly Val Lys Val Glu Arg 
                165                 170                 175     


Gln Val Phe Gly Glu Ala Thr Lys Gln Pro Gly Ile Thr Phe Ile Ala 
            180                 185                 190         


Ala Lys Phe Asp Gly Ile Leu Gly Met Ala Tyr Pro Arg Ile Ser Val 
        195                 200                 205             


Asn Asn Val Leu Pro Val Phe Asp Asn Leu Met Gln Gln Lys Leu Val 
    210                 215                 220                 


Asp Gln Asn Ile Phe Ser Phe Tyr Leu Ser Arg Asp Pro Asp Ala Gln 
225                 230                 235                 240 


Pro Gly Gly Glu Leu Met Leu Gly Gly Thr Asp Ser Lys Tyr Tyr Lys 
                245                 250                 255     


Gly Ser Leu Ser Tyr Leu Asn Val Thr Arg Lys Ala Tyr Trp Gln Val 
            260                 265                 270         


His Leu Asp Gln Val Glu Val Ala Ser Gly Leu Thr Leu Cys Lys Glu 
        275                 280                 285             


Gly Cys Glu Ala Ile Val Asp Thr Gly Thr Ser Leu Met Val Gly Pro 
    290                 295                 300                 


Val Asp Glu Val Arg Glu Leu Gln Lys Ala Ile Gly Ala Val Pro Leu 
305                 310                 315                 320 


Ile Gln Gly Glu Tyr Met Ile Pro Cys Glu Lys Val Ser Thr Leu Pro 
                325                 330                 335     


Ala Ile Thr Leu Lys Leu Gly Gly Lys Gly Tyr Lys Leu Ser Pro Glu 
            340                 345                 350         


Asp Tyr Thr Leu Lys Val Ser Gln Ala Gly Lys Thr Leu Cys Leu Ser 
        355                 360                 365             


Gly Phe Met Gly Met Asp Ile Pro Pro Pro Ser Gly Pro Leu Trp Ile 
    370                 375                 380                 


Leu Gly Asp Val Phe Ile Gly Arg Tyr Tyr Thr Val Phe Asp Arg Asp 
385                 390                 395                 400 


Asn Asn Arg Val Gly Phe Ala Glu Ala Ala Arg Leu 
                405                 410         


<210>  55
<211>  921
<212>  DNA
<213>  Homo sapiens

<400>  55
atggcgtcgc ccggctgcct gtggctcttg gctgtggctc tcctgccatg gacctgcgct       60

tctcgggcgc tgcagcatct ggacccgccg gcgccgctgc cgttggtgat ctggcatggg      120

atgggagaca gctgttgcaa tcccttaagc atgggtgcta ttaaaaaaat ggtggagaag      180

aaaatacctg gaatttacgt cttatcttta gagattggga agaccctgat ggaggacgtg      240

gagaacagct tcttcttgaa tgtcaattcc caagtaacaa cagtgtgtca ggcacttgct      300

aaggatccta aattgcagca aggctacaat gctatgggat tctcccaggg aggccaattt      360

ctgagggcag tggctcagag atgcccttca cctcccatga tcaatctgat ctcggttggg      420

ggacaacatc aaggtgtttt tggactccct cgatgcccag gagagagctc tcacatctgt      480

gacttcatcc gaaaaacact gaatgctggg gcgtactcca aagttgttca ggaacgcctc      540

gtgcaagccg aatactggca tgaccccata aaggaggatg tgtatcgcaa ccacagcatc      600

ttcttggcag atataaatca ggagcggggt atcaatgagt cctacaagaa aaacctgatg      660

gccctgaaga agtttgtgat ggtgaaattc ctcaatgatt ccattgtgga ccctgtagat      720

tcggagtggt ttggatttta cagaagtggc caagccaagg aaaccattcc cttacaggag      780

acctccctgt acacacagga ccgcctgggg ctaaaggaaa tggacaatgc aggacagcta      840

gtgtttctgg ctacagaagg ggaccatctt cagttgtctg aagaatggtt ttatgcccac      900

atcataccat tccttggatg a                                                921


<210>  56
<211>  306
<212>  PRT
<213>  Homo sapiens

<400>  56

Met Ala Ser Pro Gly Cys Leu Trp Leu Leu Ala Val Ala Leu Leu Pro 
1               5                   10                  15      


Trp Thr Cys Ala Ser Arg Ala Leu Gln His Leu Asp Pro Pro Ala Pro 
            20                  25                  30          


Leu Pro Leu Val Ile Trp His Gly Met Gly Asp Ser Cys Cys Asn Pro 
        35                  40                  45              


Leu Ser Met Gly Ala Ile Lys Lys Met Val Glu Lys Lys Ile Pro Gly 
    50                  55                  60                  


Ile Tyr Val Leu Ser Leu Glu Ile Gly Lys Thr Leu Met Glu Asp Val 
65                  70                  75                  80  


Glu Asn Ser Phe Phe Leu Asn Val Asn Ser Gln Val Thr Thr Val Cys 
                85                  90                  95      


Gln Ala Leu Ala Lys Asp Pro Lys Leu Gln Gln Gly Tyr Asn Ala Met 
            100                 105                 110         


Gly Phe Ser Gln Gly Gly Gln Phe Leu Arg Ala Val Ala Gln Arg Cys 
        115                 120                 125             


Pro Ser Pro Pro Met Ile Asn Leu Ile Ser Val Gly Gly Gln His Gln 
    130                 135                 140                 


Gly Val Phe Gly Leu Pro Arg Cys Pro Gly Glu Ser Ser His Ile Cys 
145                 150                 155                 160 


Asp Phe Ile Arg Lys Thr Leu Asn Ala Gly Ala Tyr Ser Lys Val Val 
                165                 170                 175     


Gln Glu Arg Leu Val Gln Ala Glu Tyr Trp His Asp Pro Ile Lys Glu 
            180                 185                 190         


Asp Val Tyr Arg Asn His Ser Ile Phe Leu Ala Asp Ile Asn Gln Glu 
        195                 200                 205             


Arg Gly Ile Asn Glu Ser Tyr Lys Lys Asn Leu Met Ala Leu Lys Lys 
    210                 215                 220                 


Phe Val Met Val Lys Phe Leu Asn Asp Ser Ile Val Asp Pro Val Asp 
225                 230                 235                 240 


Ser Glu Trp Phe Gly Phe Tyr Arg Ser Gly Gln Ala Lys Glu Thr Ile 
                245                 250                 255     


Pro Leu Gln Glu Thr Ser Leu Tyr Thr Gln Asp Arg Leu Gly Leu Lys 
            260                 265                 270         


Glu Met Asp Asn Ala Gly Gln Leu Val Phe Leu Ala Thr Glu Gly Asp 
        275                 280                 285             


His Leu Gln Leu Ser Glu Glu Trp Phe Tyr Ala His Ile Ile Pro Phe 
    290                 295                 300                 


Leu Gly 
305     


<210>  57
<211>  1509
<212>  DNA
<213>  Homo sapiens

<400>  57
atgagctgcc ccgtgcccgc ctgctgcgcg ctgctgctag tcctggggct ctgccgggcg       60

cgtccccgga acgcactgct gctcctcgcg gatgacggag gctttgagag tggcgcgtac      120

aacaacagcg ccatcgccac cccgcacctg gacgccttgg cccgccgcag cctcctcttt      180

cgcaatgcct tcacctcggt cagcagctgc tctcccagcc gcgccagcct cctcactggc      240

ctgccccagc atcagaatgg gatgtacggg ctgcaccagg acgtgcacca cttcaactcc      300

ttcgacaagg tgcggagcct gccgctgctg ctcagccaag ctggtgtgcg cacaggcatc      360

atcgggaaga agcacgtggg gccggagacc gtgtacccgt ttgactttgc gtacacggag      420

gagaatggct ccgtcctcca ggtggggcgg aacatcacta gaattaagct gctcgtccgg      480

aaattcctgc agactcagga tgaccggcct ttcttcctct acgtcgcctt ccacgacccc      540

caccgctgtg ggcactccca gccccagtac ggaaccttct gtgagaagtt tggcaacgga      600

gagagcggca tgggtcgtat cccagactgg accccccagg cctacgaccc actggacgtg      660

ctggtgcctt acttcgtccc caacaccccg gcagcccgag ccgacctggc cgctcagtac      720

accaccgtag gccgcatgga ccaaggagtt ggactggtgc tccaggagct gcgtgacgcc      780

ggtgtcctga acgacacact ggtgatcttc acgtccgaca acgggatccc cttccccagc      840

ggcaggacca acctgtactg gccgggcact gctgaaccct tactggtgtc atccccggag      900

cacccaaaac gctggggcca agtcagcgag gcctacgtga gcctcctaga cctcacgccc      960

accatcttgg attggttctc gatcccgtac cccagctacg ccatctttgg ctcgaagacc     1020

atccacctca ctggccggtc cctcctgccg gcgctggagg ccgagcccct ctgggccacc     1080

gtctttggca gccagagcca ccacgaggtc accatgtcct accccatgcg ctccgtgcag     1140

caccggcact tccgcctcgt gcacaacctc aacttcaaga tgccctttcc catcgaccag     1200

gacttctacg tctcacccac cttccaggac ctcctgaacc gcactacagc tggtcagccc     1260

acgggctggt acaaggacct ccgtcattac tactaccggg cgcgctggga gctctacgac     1320

cggagccggg acccccacga gacccagaac ctggccaccg acccgcgctt tgctcagctt     1380

ctggagatgc ttcgggacca gctggccaag tggcagtggg agacccacga cccctgggtg     1440

tgcgcccccg acggcgtcct ggaggagaag ctctctcccc agtgccagcc cctccacaat     1500

gagctgtga                                                             1509


<210>  58
<211>  502
<212>  PRT
<213>  Homo sapiens

<400>  58

Met Ser Cys Pro Val Pro Ala Cys Cys Ala Leu Leu Leu Val Leu Gly 
1               5                   10                  15      


Leu Cys Arg Ala Arg Pro Arg Asn Ala Leu Leu Leu Leu Ala Asp Asp 
            20                  25                  30          


Gly Gly Phe Glu Ser Gly Ala Tyr Asn Asn Ser Ala Ile Ala Thr Pro 
        35                  40                  45              


His Leu Asp Ala Leu Ala Arg Arg Ser Leu Leu Phe Arg Asn Ala Phe 
    50                  55                  60                  


Thr Ser Val Ser Ser Cys Ser Pro Ser Arg Ala Ser Leu Leu Thr Gly 
65                  70                  75                  80  


Leu Pro Gln His Gln Asn Gly Met Tyr Gly Leu His Gln Asp Val His 
                85                  90                  95      


His Phe Asn Ser Phe Asp Lys Val Arg Ser Leu Pro Leu Leu Leu Ser 
            100                 105                 110         


Gln Ala Gly Val Arg Thr Gly Ile Ile Gly Lys Lys His Val Gly Pro 
        115                 120                 125             


Glu Thr Val Tyr Pro Phe Asp Phe Ala Tyr Thr Glu Glu Asn Gly Ser 
    130                 135                 140                 


Val Leu Gln Val Gly Arg Asn Ile Thr Arg Ile Lys Leu Leu Val Arg 
145                 150                 155                 160 


Lys Phe Leu Gln Thr Gln Asp Asp Arg Pro Phe Phe Leu Tyr Val Ala 
                165                 170                 175     


Phe His Asp Pro His Arg Cys Gly His Ser Gln Pro Gln Tyr Gly Thr 
            180                 185                 190         


Phe Cys Glu Lys Phe Gly Asn Gly Glu Ser Gly Met Gly Arg Ile Pro 
        195                 200                 205             


Asp Trp Thr Pro Gln Ala Tyr Asp Pro Leu Asp Val Leu Val Pro Tyr 
    210                 215                 220                 


Phe Val Pro Asn Thr Pro Ala Ala Arg Ala Asp Leu Ala Ala Gln Tyr 
225                 230                 235                 240 


Thr Thr Val Gly Arg Met Asp Gln Gly Val Gly Leu Val Leu Gln Glu 
                245                 250                 255     


Leu Arg Asp Ala Gly Val Leu Asn Asp Thr Leu Val Ile Phe Thr Ser 
            260                 265                 270         


Asp Asn Gly Ile Pro Phe Pro Ser Gly Arg Thr Asn Leu Tyr Trp Pro 
        275                 280                 285             


Gly Thr Ala Glu Pro Leu Leu Val Ser Ser Pro Glu His Pro Lys Arg 
    290                 295                 300                 


Trp Gly Gln Val Ser Glu Ala Tyr Val Ser Leu Leu Asp Leu Thr Pro 
305                 310                 315                 320 


Thr Ile Leu Asp Trp Phe Ser Ile Pro Tyr Pro Ser Tyr Ala Ile Phe 
                325                 330                 335     


Gly Ser Lys Thr Ile His Leu Thr Gly Arg Ser Leu Leu Pro Ala Leu 
            340                 345                 350         


Glu Ala Glu Pro Leu Trp Ala Thr Val Phe Gly Ser Gln Ser His His 
        355                 360                 365             


Glu Val Thr Met Ser Tyr Pro Met Arg Ser Val Gln His Arg His Phe 
    370                 375                 380                 


Arg Leu Val His Asn Leu Asn Phe Lys Met Pro Phe Pro Ile Asp Gln 
385                 390                 395                 400 


Asp Phe Tyr Val Ser Pro Thr Phe Gln Asp Leu Leu Asn Arg Thr Thr 
                405                 410                 415     


Ala Gly Gln Pro Thr Gly Trp Tyr Lys Asp Leu Arg His Tyr Tyr Tyr 
            420                 425                 430         


Arg Ala Arg Trp Glu Leu Tyr Asp Arg Ser Arg Asp Pro His Glu Thr 
        435                 440                 445             


Gln Asn Leu Ala Thr Asp Pro Arg Phe Ala Gln Leu Leu Glu Met Leu 
    450                 455                 460                 


Arg Asp Gln Leu Ala Lys Trp Gln Trp Glu Thr His Asp Pro Trp Val 
465                 470                 475                 480 


Cys Ala Pro Asp Gly Val Leu Glu Glu Lys Leu Ser Pro Gln Cys Gln 
                485                 490                 495     


Pro Leu His Asn Glu Leu 
            500         


<210>  59
<211>  1962
<212>  DNA
<213>  Homo sapiens

<400>  59
atgcgtcccc tgcgcccccg cgccgcgctg ctggcgctcc tggcctcgct cctggccgcg       60

cccccggtgg ccccggccga ggccccgcac ctggtgcatg tggacgcggc ccgcgcgctg      120

tggcccctgc ggcgcttctg gaggagcaca ggcttctgcc ccccgctgcc acacagccag      180

gctgaccagt acgtcctcag ctgggaccag cagctcaacc tcgcctatgt gggcgccgtc      240

cctcaccgcg gcatcaagca ggtccggacc cactggctgc tggagcttgt caccaccagg      300

gggtccactg gacggggcct gagctacaac ttcacccacc tggacgggta cctggacctt      360

ctcagggaga accagctcct cccagggttt gagctgatgg gcagcgcctc gggccacttc      420

actgactttg aggacaagca gcaggtgttt gagtggaagg acttggtctc cagcctggcc      480

aggagataca tcggtaggta cggactggcg catgtttcca agtggaactt cgagacgtgg      540

aatgagccag accaccacga ctttgacaac gtctccatga ccatgcaagg cttcctgaac      600

tactacgatg cctgctcgga gggtctgcgc gccgccagcc ccgccctgcg gctgggaggc      660

cccggcgact ccttccacac cccaccgcga tccccgctga gctggggcct cctgcgccac      720

tgccacgacg gtaccaactt cttcactggg gaggcgggcg tgcggctgga ctacatctcc      780

ctccacagga agggtgcgcg cagctccatc tccatcctgg agcaggagaa ggtcgtcgcg      840

cagcagatcc ggcagctctt ccccaagttc gcggacaccc ccatttacaa cgacgaggcg      900

gacccgctgg tgggctggtc cctgccacag ccgtggaggg cggacgtgac ctacgcggcc      960

atggtggtga aggtcatcgc gcagcatcag aacctgctac tggccaacac cacctccgcc     1020

ttcccctacg cgctcctgag caacgacaat gccttcctga gctaccaccc gcaccccttc     1080

gcgcagcgca cgctcaccgc gcgcttccag gtcaacaaca cccgcccgcc gcacgtgcag     1140

ctgttgcgca agccggtgct cacggccatg gggctgctgg cgctgctgga tgaggagcag     1200

ctctgggccg aagtgtcgca ggccgggacc gtcctggaca gcaaccacac ggtgggcgtc     1260

ctggccagcg cccaccgccc ccagggcccg gccgacgcct ggcgcgccgc ggtgctgatc     1320

tacgcgagcg acgacacccg cgcccacccc aaccgcagcg tcgcggtgac cctgcggctg     1380

cgcggggtgc cccccggccc gggcctggtc tacgtcacgc gctacctgga caacgggctc     1440

tgcagccccg acggcgagtg gcggcgcctg ggccggcccg tcttccccac ggcagagcag     1500

ttccggcgca tgcgcgcggc tgaggacccg gtggccgcgg cgccccgccc cttacccgcc     1560

ggcggccgcc tgaccctgcg ccccgcgctg cggctgccgt cgcttttgct ggtgcacgtg     1620

tgtgcgcgcc ccgagaagcc gcccgggcag gtcacgcggc tccgcgccct gcccctgacc     1680

caagggcagc tggttctggt ctggtcggat gaacacgtgg gctccaagtg cctgtggaca     1740

tacgagatcc agttctctca ggacggtaag gcgtacaccc cggtcagcag gaagccatcg     1800

accttcaacc tctttgtgtt cagcccagac acaggtgctg tctctggctc ctaccgagtt     1860

cgagccctgg actactgggc ccgaccaggc cccttctcgg accctgtgcc gtacctggag     1920

gtccctgtgc caagagggcc cccatccccg ggcaatccat ga                        1962


<210>  60
<211>  653
<212>  PRT
<213>  Homo sapiens

<400>  60

Met Arg Pro Leu Arg Pro Arg Ala Ala Leu Leu Ala Leu Leu Ala Ser 
1               5                   10                  15      


Leu Leu Ala Ala Pro Pro Val Ala Pro Ala Glu Ala Pro His Leu Val 
            20                  25                  30          


His Val Asp Ala Ala Arg Ala Leu Trp Pro Leu Arg Arg Phe Trp Arg 
        35                  40                  45              


Ser Thr Gly Phe Cys Pro Pro Leu Pro His Ser Gln Ala Asp Gln Tyr 
    50                  55                  60                  


Val Leu Ser Trp Asp Gln Gln Leu Asn Leu Ala Tyr Val Gly Ala Val 
65                  70                  75                  80  


Pro His Arg Gly Ile Lys Gln Val Arg Thr His Trp Leu Leu Glu Leu 
                85                  90                  95      


Val Thr Thr Arg Gly Ser Thr Gly Arg Gly Leu Ser Tyr Asn Phe Thr 
            100                 105                 110         


His Leu Asp Gly Tyr Leu Asp Leu Leu Arg Glu Asn Gln Leu Leu Pro 
        115                 120                 125             


Gly Phe Glu Leu Met Gly Ser Ala Ser Gly His Phe Thr Asp Phe Glu 
    130                 135                 140                 


Asp Lys Gln Gln Val Phe Glu Trp Lys Asp Leu Val Ser Ser Leu Ala 
145                 150                 155                 160 


Arg Arg Tyr Ile Gly Arg Tyr Gly Leu Ala His Val Ser Lys Trp Asn 
                165                 170                 175     


Phe Glu Thr Trp Asn Glu Pro Asp His His Asp Phe Asp Asn Val Ser 
            180                 185                 190         


Met Thr Met Gln Gly Phe Leu Asn Tyr Tyr Asp Ala Cys Ser Glu Gly 
        195                 200                 205             


Leu Arg Ala Ala Ser Pro Ala Leu Arg Leu Gly Gly Pro Gly Asp Ser 
    210                 215                 220                 


Phe His Thr Pro Pro Arg Ser Pro Leu Ser Trp Gly Leu Leu Arg His 
225                 230                 235                 240 


Cys His Asp Gly Thr Asn Phe Phe Thr Gly Glu Ala Gly Val Arg Leu 
                245                 250                 255     


Asp Tyr Ile Ser Leu His Arg Lys Gly Ala Arg Ser Ser Ile Ser Ile 
            260                 265                 270         


Leu Glu Gln Glu Lys Val Val Ala Gln Gln Ile Arg Gln Leu Phe Pro 
        275                 280                 285             


Lys Phe Ala Asp Thr Pro Ile Tyr Asn Asp Glu Ala Asp Pro Leu Val 
    290                 295                 300                 


Gly Trp Ser Leu Pro Gln Pro Trp Arg Ala Asp Val Thr Tyr Ala Ala 
305                 310                 315                 320 


Met Val Val Lys Val Ile Ala Gln His Gln Asn Leu Leu Leu Ala Asn 
                325                 330                 335     


Thr Thr Ser Ala Phe Pro Tyr Ala Leu Leu Ser Asn Asp Asn Ala Phe 
            340                 345                 350         


Leu Ser Tyr His Pro His Pro Phe Ala Gln Arg Thr Leu Thr Ala Arg 
        355                 360                 365             


Phe Gln Val Asn Asn Thr Arg Pro Pro His Val Gln Leu Leu Arg Lys 
    370                 375                 380                 


Pro Val Leu Thr Ala Met Gly Leu Leu Ala Leu Leu Asp Glu Glu Gln 
385                 390                 395                 400 


Leu Trp Ala Glu Val Ser Gln Ala Gly Thr Val Leu Asp Ser Asn His 
                405                 410                 415     


Thr Val Gly Val Leu Ala Ser Ala His Arg Pro Gln Gly Pro Ala Asp 
            420                 425                 430         


Ala Trp Arg Ala Ala Val Leu Ile Tyr Ala Ser Asp Asp Thr Arg Ala 
        435                 440                 445             


His Pro Asn Arg Ser Val Ala Val Thr Leu Arg Leu Arg Gly Val Pro 
    450                 455                 460                 


Pro Gly Pro Gly Leu Val Tyr Val Thr Arg Tyr Leu Asp Asn Gly Leu 
465                 470                 475                 480 


Cys Ser Pro Asp Gly Glu Trp Arg Arg Leu Gly Arg Pro Val Phe Pro 
                485                 490                 495     


Thr Ala Glu Gln Phe Arg Arg Met Arg Ala Ala Glu Asp Pro Val Ala 
            500                 505                 510         


Ala Ala Pro Arg Pro Leu Pro Ala Gly Gly Arg Leu Thr Leu Arg Pro 
        515                 520                 525             


Ala Leu Arg Leu Pro Ser Leu Leu Leu Val His Val Cys Ala Arg Pro 
    530                 535                 540                 


Glu Lys Pro Pro Gly Gln Val Thr Arg Leu Arg Ala Leu Pro Leu Thr 
545                 550                 555                 560 


Gln Gly Gln Leu Val Leu Val Trp Ser Asp Glu His Val Gly Ser Lys 
                565                 570                 575     


Cys Leu Trp Thr Tyr Glu Ile Gln Phe Ser Gln Asp Gly Lys Ala Tyr 
            580                 585                 590         


Thr Pro Val Ser Arg Lys Pro Ser Thr Phe Asn Leu Phe Val Phe Ser 
        595                 600                 605             


Pro Asp Thr Gly Ala Val Ser Gly Ser Tyr Arg Val Arg Ala Leu Asp 
    610                 615                 620                 


Tyr Trp Ala Arg Pro Gly Pro Phe Ser Asp Pro Val Pro Tyr Leu Glu 
625                 630                 635                 640 


Val Pro Val Pro Arg Gly Pro Pro Ser Pro Gly Asn Pro 
                645                 650             


<210>  61
<211>  1653
<212>  DNA
<213>  Homo sapiens

<400>  61
atgccgccac cccggaccgg ccgaggcctt ctctggctgg gtctggttct gagctccgtc       60

tgcgtcgccc tcggatccga aacgcaggcc aactcgacca cagatgctct gaacgttctt      120

ctcatcatcg tggatgacct gcgcccctcc ctgggctgtt atggggataa gctggtgagg      180

tccccaaata ttgaccaact ggcatcccac agcctcctct tccagaatgc ctttgcgcag      240

caagcagtgt gcgccccgag ccgcgtttct ttcctcactg gcaggagacc tgacaccacc      300

cgcctgtacg acttcaactc ctactggagg gtgcacgctg gaaacttctc caccatcccc      360

cagtacttca aggagaatgg ctatgtgacc atgtcggtgg gaaaagtctt tcaccctggg      420

atatcttcta accataccga tgattctccg tatagctggt cttttccacc ttatcatcct      480

tcctctgaga agtatgaaaa cactaagaca tgtcgagggc cagatggaga actccatgcc      540

aacctgcttt gccctgtgga tgtgctggat gttcccgagg gcaccttgcc tgacaaacag      600

agcactgagc aagccataca gttgttggaa aagatgaaaa cgtcagccag tcctttcttc      660

ctggccgttg ggtatcataa gccacacatc cccttcagat accccaagga atttcagaag      720

ttgtatccct tggagaacat caccctggcc cccgatcccg aggtccctga tggcctaccc      780

cctgtggcct acaacccctg gatggacatc aggcaacggg aagacgtcca agccttaaac      840

atcagtgtgc cgtatggtcc aattcctgtg gactttcagc ggaaaatccg ccagagctac      900

tttgcctctg tgtcatattt ggatacacag gtcggccgcc tcttgagtgc tttggacgat      960

cttcagctgg ccaacagcac catcattgca tttacctcgg atcatgggtg ggctctaggt     1020

gaacatggag aatgggccaa atacagcaat tttgatgttg ctacccatgt tcccctgata     1080

ttctatgttc ctggaaggac ggcttcactt ccggaggcag gcgagaagct tttcccttac     1140

ctcgaccctt ttgattccgc ctcacagttg atggagccag gcaggcaatc catggacctt     1200

gtggaacttg tgtctctttt tcccacgctg gctggacttg caggactgca ggttccacct     1260

cgctgccccg ttccttcatt tcacgttgag ctgtgcagag aaggcaagaa ccttctgaag     1320

cattttcgat tccgtgactt ggaagaggat ccgtacctcc ctggtaatcc ccgtgaactg     1380

attgcctata gccagtatcc ccggccttca gacatccctc agtggaattc tgacaagccg     1440

agtttaaaag atataaagat catgggctat tccatacgca ccatagacta taggtatact     1500

gtgtgggttg gcttcaatcc tgatgaattt ctagctaact tttctgacat ccatgcaggg     1560

gaactgtatt ttgtggattc tgacccattg caggatcaca atatgtataa tgattcccaa     1620

ggtggagatc ttttccagtt gttgatgcct tga                                  1653


<210>  62
<211>  550
<212>  PRT
<213>  Homo sapiens

<400>  62

Met Pro Pro Pro Arg Thr Gly Arg Gly Leu Leu Trp Leu Gly Leu Val 
1               5                   10                  15      


Leu Ser Ser Val Cys Val Ala Leu Gly Ser Glu Thr Gln Ala Asn Ser 
            20                  25                  30          


Thr Thr Asp Ala Leu Asn Val Leu Leu Ile Ile Val Asp Asp Leu Arg 
        35                  40                  45              


Pro Ser Leu Gly Cys Tyr Gly Asp Lys Leu Val Arg Ser Pro Asn Ile 
    50                  55                  60                  


Asp Gln Leu Ala Ser His Ser Leu Leu Phe Gln Asn Ala Phe Ala Gln 
65                  70                  75                  80  


Gln Ala Val Cys Ala Pro Ser Arg Val Ser Phe Leu Thr Gly Arg Arg 
                85                  90                  95      


Pro Asp Thr Thr Arg Leu Tyr Asp Phe Asn Ser Tyr Trp Arg Val His 
            100                 105                 110         


Ala Gly Asn Phe Ser Thr Ile Pro Gln Tyr Phe Lys Glu Asn Gly Tyr 
        115                 120                 125             


Val Thr Met Ser Val Gly Lys Val Phe His Pro Gly Ile Ser Ser Asn 
    130                 135                 140                 


His Thr Asp Asp Ser Pro Tyr Ser Trp Ser Phe Pro Pro Tyr His Pro 
145                 150                 155                 160 


Ser Ser Glu Lys Tyr Glu Asn Thr Lys Thr Cys Arg Gly Pro Asp Gly 
                165                 170                 175     


Glu Leu His Ala Asn Leu Leu Cys Pro Val Asp Val Leu Asp Val Pro 
            180                 185                 190         


Glu Gly Thr Leu Pro Asp Lys Gln Ser Thr Glu Gln Ala Ile Gln Leu 
        195                 200                 205             


Leu Glu Lys Met Lys Thr Ser Ala Ser Pro Phe Phe Leu Ala Val Gly 
    210                 215                 220                 


Tyr His Lys Pro His Ile Pro Phe Arg Tyr Pro Lys Glu Phe Gln Lys 
225                 230                 235                 240 


Leu Tyr Pro Leu Glu Asn Ile Thr Leu Ala Pro Asp Pro Glu Val Pro 
                245                 250                 255     


Asp Gly Leu Pro Pro Val Ala Tyr Asn Pro Trp Met Asp Ile Arg Gln 
            260                 265                 270         


Arg Glu Asp Val Gln Ala Leu Asn Ile Ser Val Pro Tyr Gly Pro Ile 
        275                 280                 285             


Pro Val Asp Phe Gln Arg Lys Ile Arg Gln Ser Tyr Phe Ala Ser Val 
    290                 295                 300                 


Ser Tyr Leu Asp Thr Gln Val Gly Arg Leu Leu Ser Ala Leu Asp Asp 
305                 310                 315                 320 


Leu Gln Leu Ala Asn Ser Thr Ile Ile Ala Phe Thr Ser Asp His Gly 
                325                 330                 335     


Trp Ala Leu Gly Glu His Gly Glu Trp Ala Lys Tyr Ser Asn Phe Asp 
            340                 345                 350         


Val Ala Thr His Val Pro Leu Ile Phe Tyr Val Pro Gly Arg Thr Ala 
        355                 360                 365             


Ser Leu Pro Glu Ala Gly Glu Lys Leu Phe Pro Tyr Leu Asp Pro Phe 
    370                 375                 380                 


Asp Ser Ala Ser Gln Leu Met Glu Pro Gly Arg Gln Ser Met Asp Leu 
385                 390                 395                 400 


Val Glu Leu Val Ser Leu Phe Pro Thr Leu Ala Gly Leu Ala Gly Leu 
                405                 410                 415     


Gln Val Pro Pro Arg Cys Pro Val Pro Ser Phe His Val Glu Leu Cys 
            420                 425                 430         


Arg Glu Gly Lys Asn Leu Leu Lys His Phe Arg Phe Arg Asp Leu Glu 
        435                 440                 445             


Glu Asp Pro Tyr Leu Pro Gly Asn Pro Arg Glu Leu Ile Ala Tyr Ser 
    450                 455                 460                 


Gln Tyr Pro Arg Pro Ser Asp Ile Pro Gln Trp Asn Ser Asp Lys Pro 
465                 470                 475                 480 


Ser Leu Lys Asp Ile Lys Ile Met Gly Tyr Ser Ile Arg Thr Ile Asp 
                485                 490                 495     


Tyr Arg Tyr Thr Val Trp Val Gly Phe Asn Pro Asp Glu Phe Leu Ala 
            500                 505                 510         


Asn Phe Ser Asp Ile His Ala Gly Glu Leu Tyr Phe Val Asp Ser Asp 
        515                 520                 525             


Pro Leu Gln Asp His Asn Met Tyr Asn Asp Ser Gln Gly Gly Asp Leu 
    530                 535                 540                 


Phe Gln Leu Leu Met Pro 
545                 550 


<210>  63
<211>  1524
<212>  DNA
<213>  Homo sapiens

<400>  63
atgggggcac cgcggtccct cctcctggcc ctggctgctg gcctggccgt tgcccgtccg       60

cccaacatcg tgctgatctt tgccgacgac ctcggctatg gggacctggg ctgctatggg      120

caccccagct ctaccactcc caacctggac cagctggcgg cgggagggct gcggttcaca      180

gacttctacg tgcctgtgtc tctgtgcaca ccctctaggg ccgccctcct gaccggccgg      240

ctcccggttc ggatgggcat gtaccctggc gtcctggtgc ccagctcccg ggggggcctg      300

cccctggagg aggtgaccgt ggccgaagtc ctggctgccc gaggctacct cacaggaatg      360

gccggcaagt ggcaccttgg ggtggggcct gagggggcct tcctgccccc ccatcagggc      420

ttccatcgat ttctaggcat cccgtactcc cacgaccagg gcccctgcca gaacctgacc      480

tgcttcccgc cggccactcc ttgcgacggt ggctgtgacc agggcctggt ccccatccca      540

ctgttggcca acctgtccgt ggaggcgcag cccccctggc tgcccggact agaggcccgc      600

tacatggctt tcgcccatga cctcatggcc gacgcccagc gccaggatcg ccccttcttc      660

ctgtactatg cctctcacca cacccactac cctcagttca gtgggcagag ctttgcagag      720

cgttcaggcc gcgggccatt tggggactcc ctgatggagc tggatgcagc tgtggggacc      780

ctgatgacag ccatagggga cctggggctg cttgaagaga cgctggtcat cttcactgca      840

gacaatggac ctgagaccat gcgtatgtcc cgaggcggct gctccggtct cttgcggtgt      900

ggaaagggaa cgacctacga gggcggtgtc cgagagcctg ccttggcctt ctggccaggt      960

catatcgctc ccggcgtgac ccacgagctg gccagctccc tggacctgct gcctaccctg     1020

gcagccctgg ctggggcccc actgcccaat gtcaccttgg atggctttga cctcagcccc     1080

ctgctgctgg gcacaggcaa gagccctcgg cagtctctct tcttctaccc gtcctaccca     1140

gacgaggtcc gtggggtttt tgctgtgcgg actggaaagt acaaggctca cttcttcacc     1200

cagggctctg cccacagtga taccactgca gaccctgcct gccacgcctc cagctctctg     1260

actgctcatg agcccccgct gctctatgac ctgtccaagg accctggtga gaactacaac     1320

ctgctggggg gtgtggccgg ggccacccca gaggtgctgc aagccctgaa acagcttcag     1380

ctgctcaagg cccagttaga cgcagctgtg accttcggcc ccagccaggt ggcccggggc     1440

gaggaccccg ccctgcagat ctgctgtcat cctggctgca ccccccgccc agcttgctgc     1500

cattgcccag atccccatgc ctga                                            1524


<210>  64
<211>  507
<212>  PRT
<213>  Homo sapiens

<400>  64

Met Gly Ala Pro Arg Ser Leu Leu Leu Ala Leu Ala Ala Gly Leu Ala 
1               5                   10                  15      


Val Ala Arg Pro Pro Asn Ile Val Leu Ile Phe Ala Asp Asp Leu Gly 
            20                  25                  30          


Tyr Gly Asp Leu Gly Cys Tyr Gly His Pro Ser Ser Thr Thr Pro Asn 
        35                  40                  45              


Leu Asp Gln Leu Ala Ala Gly Gly Leu Arg Phe Thr Asp Phe Tyr Val 
    50                  55                  60                  


Pro Val Ser Leu Cys Thr Pro Ser Arg Ala Ala Leu Leu Thr Gly Arg 
65                  70                  75                  80  


Leu Pro Val Arg Met Gly Met Tyr Pro Gly Val Leu Val Pro Ser Ser 
                85                  90                  95      


Arg Gly Gly Leu Pro Leu Glu Glu Val Thr Val Ala Glu Val Leu Ala 
            100                 105                 110         


Ala Arg Gly Tyr Leu Thr Gly Met Ala Gly Lys Trp His Leu Gly Val 
        115                 120                 125             


Gly Pro Glu Gly Ala Phe Leu Pro Pro His Gln Gly Phe His Arg Phe 
    130                 135                 140                 


Leu Gly Ile Pro Tyr Ser His Asp Gln Gly Pro Cys Gln Asn Leu Thr 
145                 150                 155                 160 


Cys Phe Pro Pro Ala Thr Pro Cys Asp Gly Gly Cys Asp Gln Gly Leu 
                165                 170                 175     


Val Pro Ile Pro Leu Leu Ala Asn Leu Ser Val Glu Ala Gln Pro Pro 
            180                 185                 190         


Trp Leu Pro Gly Leu Glu Ala Arg Tyr Met Ala Phe Ala His Asp Leu 
        195                 200                 205             


Met Ala Asp Ala Gln Arg Gln Asp Arg Pro Phe Phe Leu Tyr Tyr Ala 
    210                 215                 220                 


Ser His His Thr His Tyr Pro Gln Phe Ser Gly Gln Ser Phe Ala Glu 
225                 230                 235                 240 


Arg Ser Gly Arg Gly Pro Phe Gly Asp Ser Leu Met Glu Leu Asp Ala 
                245                 250                 255     


Ala Val Gly Thr Leu Met Thr Ala Ile Gly Asp Leu Gly Leu Leu Glu 
            260                 265                 270         


Glu Thr Leu Val Ile Phe Thr Ala Asp Asn Gly Pro Glu Thr Met Arg 
        275                 280                 285             


Met Ser Arg Gly Gly Cys Ser Gly Leu Leu Arg Cys Gly Lys Gly Thr 
    290                 295                 300                 


Thr Tyr Glu Gly Gly Val Arg Glu Pro Ala Leu Ala Phe Trp Pro Gly 
305                 310                 315                 320 


His Ile Ala Pro Gly Val Thr His Glu Leu Ala Ser Ser Leu Asp Leu 
                325                 330                 335     


Leu Pro Thr Leu Ala Ala Leu Ala Gly Ala Pro Leu Pro Asn Val Thr 
            340                 345                 350         


Leu Asp Gly Phe Asp Leu Ser Pro Leu Leu Leu Gly Thr Gly Lys Ser 
        355                 360                 365             


Pro Arg Gln Ser Leu Phe Phe Tyr Pro Ser Tyr Pro Asp Glu Val Arg 
    370                 375                 380                 


Gly Val Phe Ala Val Arg Thr Gly Lys Tyr Lys Ala His Phe Phe Thr 
385                 390                 395                 400 


Gln Gly Ser Ala His Ser Asp Thr Thr Ala Asp Pro Ala Cys His Ala 
                405                 410                 415     


Ser Ser Ser Leu Thr Ala His Glu Pro Pro Leu Leu Tyr Asp Leu Ser 
            420                 425                 430         


Lys Asp Pro Gly Glu Asn Tyr Asn Leu Leu Gly Gly Val Ala Gly Ala 
        435                 440                 445             


Thr Pro Glu Val Leu Gln Ala Leu Lys Gln Leu Gln Leu Leu Lys Ala 
    450                 455                 460                 


Gln Leu Asp Ala Ala Val Thr Phe Gly Pro Ser Gln Val Ala Arg Gly 
465                 470                 475                 480 


Glu Asp Pro Ala Leu Gln Ile Cys Cys His Pro Gly Cys Thr Pro Arg 
                485                 490                 495     


Pro Ala Cys Cys His Cys Pro Asp Pro His Ala 
            500                 505         


<210>  65
<211>  2010
<212>  DNA
<213>  Homo sapiens

<400>  65
atggctgcag ccgcgggttc ggcgggccgc gccgcggtgc ccttgctgct gtgtgcgctg       60

ctggcgcccg gcggcgcgta cgtgctcgac gactccgacg ggctgggccg ggagttcgac      120

ggcatcggcg cggtcagcgg cggcggggca acctcccgac ttctagtaaa ttacccagag      180

ccctatcgtt ctcagatatt ggattatctc tttaagccga attttggtgc ctctttgcat      240

attttaaaag tggaaatagg tggtgatggg cagacaacag atggcactga gccctcccac      300

atgcattatg cactagatga gaattatttc cgaggatacg agtggtggtt gatgaaagaa      360

gctaagaaga ggaatcccaa tattacactc attgggttgc catggtcatt ccctggatgg      420

ctgggaaaag gtttcgactg gccttatgtc aatcttcagc tgactgccta ttatgtcgtg      480

acctggattg tgggcgccaa gcgttaccat gatttggaca ttgattatat tggaatttgg      540

aatgagaggt catataatgc caattatatt aagatattaa gaaaaatgct gaattatcaa      600

ggtctccagc gagtgaaaat catagcaagt gataatctct gggagtccat ctctgcatcc      660

atgctccttg atgccgaact cttcaaggtg gttgatgtta taggggctca ttatcctgga      720

acccattcag caaaagatgc aaagttgact gggaagaagc tttggtcttc tgaagacttt      780

agcactttaa atagtgacat gggtgcaggc tgctggggtc gcattttaaa tcagaattat      840

atcaatggct atatgacttc cacaatcgca tggaatttag tggctagtta ctatgaacag      900

ttgccttatg ggagatgcgg gttgatgacg gcccaggagc catggagtgg gcactacgtg      960

gtagaatctc ctgtctgggt atcagctcat accactcagt ttactcaacc tggctggtat     1020

tacctgaaga cagttggcca tttagagaaa ggaggaagct acgtagctct gactgatggc     1080

ttagggaacc tcaccatcat cattgaaacc atgagtcata aacattctaa gtgcatacgg     1140

ccatttcttc cttatttcaa tgtgtcacaa caatttgcca cctttgttct taagggatct     1200

tttagtgaaa taccagagct acaggtatgg tataccaaac ttggaaaaac atccgaaaga     1260

tttcttttta agcagctgga ttctctatgg ctccttgaca gcgatggcag tttcacactg     1320

agcctgcatg aagatgagct gttcacactc accactctca ccactggtcg caaaggcagc     1380

tacccgcttc ctccaaaatc ccagcccttc ccaagtacct ataaggatga tttcaatgtt     1440

gattacccat tttttagtga agctccaaac tttgctgatc aaactggtgt atttgaatat     1500

tttacaaata ttgaagaccc tggcgagcat cacttcacgc tacgccaagt tctcaaccag     1560

agacccatta cgtgggctgc cgatgcatcc aacacaatca gtattatagg agactacaac     1620

tggaccaatc tgactacaaa gtgtgatgtt tacatagaga cccctgacac aggaggtgtg     1680

ttcattgcag gaagagtaaa taaaggtggt attttgatta gaagtgccag aggaattttc     1740

ttctggattt ttgcaaatgg atcttacagg gttacaggtg atttagctgg atggattata     1800

tatgctttag gacgtgttga agttacagca aaaaaatggt atacactcac gttaactatt     1860

aagggtcatt tcgcctctgg catgctgaat gacaagtctc tgtggacaga catccctgtg     1920

aattttccaa agaatggctg ggctgcaatt ggaactcact cctttgaatt tgcacagttt     1980

gacaactttc ttgtggaagc cacacgctaa                                      2010


<210>  66
<211>  669
<212>  PRT
<213>  Homo sapiens

<400>  66

Met Ala Ala Ala Ala Gly Ser Ala Gly Arg Ala Ala Val Pro Leu Leu 
1               5                   10                  15      


Leu Cys Ala Leu Leu Ala Pro Gly Gly Ala Tyr Val Leu Asp Asp Ser 
            20                  25                  30          


Asp Gly Leu Gly Arg Glu Phe Asp Gly Ile Gly Ala Val Ser Gly Gly 
        35                  40                  45              


Gly Ala Thr Ser Arg Leu Leu Val Asn Tyr Pro Glu Pro Tyr Arg Ser 
    50                  55                  60                  


Gln Ile Leu Asp Tyr Leu Phe Lys Pro Asn Phe Gly Ala Ser Leu His 
65                  70                  75                  80  


Ile Leu Lys Val Glu Ile Gly Gly Asp Gly Gln Thr Thr Asp Gly Thr 
                85                  90                  95      


Glu Pro Ser His Met His Tyr Ala Leu Asp Glu Asn Tyr Phe Arg Gly 
            100                 105                 110         


Tyr Glu Trp Trp Leu Met Lys Glu Ala Lys Lys Arg Asn Pro Asn Ile 
        115                 120                 125             


Thr Leu Ile Gly Leu Pro Trp Ser Phe Pro Gly Trp Leu Gly Lys Gly 
    130                 135                 140                 


Phe Asp Trp Pro Tyr Val Asn Leu Gln Leu Thr Ala Tyr Tyr Val Val 
145                 150                 155                 160 


Thr Trp Ile Val Gly Ala Lys Arg Tyr His Asp Leu Asp Ile Asp Tyr 
                165                 170                 175     


Ile Gly Ile Trp Asn Glu Arg Ser Tyr Asn Ala Asn Tyr Ile Lys Ile 
            180                 185                 190         


Leu Arg Lys Met Leu Asn Tyr Gln Gly Leu Gln Arg Val Lys Ile Ile 
        195                 200                 205             


Ala Ser Asp Asn Leu Trp Glu Ser Ile Ser Ala Ser Met Leu Leu Asp 
    210                 215                 220                 


Ala Glu Leu Phe Lys Val Val Asp Val Ile Gly Ala His Tyr Pro Gly 
225                 230                 235                 240 


Thr His Ser Ala Lys Asp Ala Lys Leu Thr Gly Lys Lys Leu Trp Ser 
                245                 250                 255     


Ser Glu Asp Phe Ser Thr Leu Asn Ser Asp Met Gly Ala Gly Cys Trp 
            260                 265                 270         


Gly Arg Ile Leu Asn Gln Asn Tyr Ile Asn Gly Tyr Met Thr Ser Thr 
        275                 280                 285             


Ile Ala Trp Asn Leu Val Ala Ser Tyr Tyr Glu Gln Leu Pro Tyr Gly 
    290                 295                 300                 


Arg Cys Gly Leu Met Thr Ala Gln Glu Pro Trp Ser Gly His Tyr Val 
305                 310                 315                 320 


Val Glu Ser Pro Val Trp Val Ser Ala His Thr Thr Gln Phe Thr Gln 
                325                 330                 335     


Pro Gly Trp Tyr Tyr Leu Lys Thr Val Gly His Leu Glu Lys Gly Gly 
            340                 345                 350         


Ser Tyr Val Ala Leu Thr Asp Gly Leu Gly Asn Leu Thr Ile Ile Ile 
        355                 360                 365             


Glu Thr Met Ser His Lys His Ser Lys Cys Ile Arg Pro Phe Leu Pro 
    370                 375                 380                 


Tyr Phe Asn Val Ser Gln Gln Phe Ala Thr Phe Val Leu Lys Gly Ser 
385                 390                 395                 400 


Phe Ser Glu Ile Pro Glu Leu Gln Val Trp Tyr Thr Lys Leu Gly Lys 
                405                 410                 415     


Thr Ser Glu Arg Phe Leu Phe Lys Gln Leu Asp Ser Leu Trp Leu Leu 
            420                 425                 430         


Asp Ser Asp Gly Ser Phe Thr Leu Ser Leu His Glu Asp Glu Leu Phe 
        435                 440                 445             


Thr Leu Thr Thr Leu Thr Thr Gly Arg Lys Gly Ser Tyr Pro Leu Pro 
    450                 455                 460                 


Pro Lys Ser Gln Pro Phe Pro Ser Thr Tyr Lys Asp Asp Phe Asn Val 
465                 470                 475                 480 


Asp Tyr Pro Phe Phe Ser Glu Ala Pro Asn Phe Ala Asp Gln Thr Gly 
                485                 490                 495     


Val Phe Glu Tyr Phe Thr Asn Ile Glu Asp Pro Gly Glu His His Phe 
            500                 505                 510         


Thr Leu Arg Gln Val Leu Asn Gln Arg Pro Ile Thr Trp Ala Ala Asp 
        515                 520                 525             


Ala Ser Asn Thr Ile Ser Ile Ile Gly Asp Tyr Asn Trp Thr Asn Leu 
    530                 535                 540                 


Thr Thr Lys Cys Asp Val Tyr Ile Glu Thr Pro Asp Thr Gly Gly Val 
545                 550                 555                 560 


Phe Ile Ala Gly Arg Val Asn Lys Gly Gly Ile Leu Ile Arg Ser Ala 
                565                 570                 575     


Arg Gly Ile Phe Phe Trp Ile Phe Ala Asn Gly Ser Tyr Arg Val Thr 
            580                 585                 590         


Gly Asp Leu Ala Gly Trp Ile Ile Tyr Ala Leu Gly Arg Val Glu Val 
        595                 600                 605             


Thr Ala Lys Lys Trp Tyr Thr Leu Thr Leu Thr Ile Lys Gly His Phe 
    610                 615                 620                 


Ala Ser Gly Met Leu Asn Asp Lys Ser Leu Trp Thr Asp Ile Pro Val 
625                 630                 635                 640 


Asn Phe Pro Lys Asn Gly Trp Ala Ala Ile Gly Thr His Ser Phe Glu 
                645                 650                 655     


Phe Ala Gln Phe Asp Asn Phe Leu Val Glu Ala Thr Arg 
            660                 665                 


<210>  67
<211>  1611
<212>  DNA
<213>  Homo sapiens

<400>  67
atggagtttt caagtccttc cagagaggaa tgtcccaagc ctttgagtag ggtaagcatc       60

atggctggca gcctcacagg attgcttcta cttcaggcag tgtcgtgggc atcaggtgcc      120

cgcccctgca tccctaaaag cttcggctac agctcggtgg tgtgtgtctg caatgccaca      180

tactgtgact cctttgaccc cccgaccttt cctgcccttg gtaccttcag ccgctatgag      240

agtacacgca gtgggcgacg gatggagctg agtatggggc ccatccaggc taatcacacg      300

ggcacaggcc tgctactgac cctgcagcca gaacagaagt tccagaaagt gaagggattt      360

ggaggggcca tgacagatgc tgctgctctc aacatccttg ccctgtcacc ccctgcccaa      420

aatttgctac ttaaatcgta cttctctgaa gaaggaatcg gatataacat catccgggta      480

cccatggcca gcagcgactt ctccatccgc acctacacct atgcagacac ccctgatgat      540

ttccagttgc acaacttcag cctcccagag gaagatacca agctcaagat acccctgatt      600

caccgagccc tgcagttggc ccagcgtccc gtttcactcc ttgccagccc ctggacatca      660

cccacttggc tcaagaccaa tggagcggtg aatgggaagg ggtcactcaa gggacagccc      720

ggagacatct accaccagac ctgggccaga tactttgtga agttcctgga tgcctatgct      780

gagcacaagt tacagttctg ggcagtgaca gctgaaaatg agccttctgc tgggctgttg      840

agtggatacc ccttccagag cctgggcttc acccctgaac atcagcgaga cttcattgcc      900

cgtgacctag gtcctaccct cgccaacagt actcaccaca atgtccgcct actcatgctg      960

gatgaccaac gcttgctgct gccccactgg gcaaaggtgg tactgacaga cccagaagca     1020

gctaaatatg ttcatggcat tgctgtacat tggtacctgg actttctggc tccagccaaa     1080

gccaccctag gggagacaca ccgcctgttc cccaacacca tgctctttgc ctcagaggcc     1140

agcgtgggct ccaagttctg ggagcagagt gtgcggctag gctcctggga tcgagggatg     1200

cagtacagcc acagcatcat cacgaacctc ctgtaccatg tggtcggctg gaccgactgg     1260

aaccttgccc tgaaccccga aggaggaccc aattgggtgc gtaactttgt cgacagtccc     1320

atcattgtag acatcaccaa ggacacgttt tacaaacagc ccatgttcta ccaccttggc     1380

cacttcagca agttcattcc tgagggctcc cagagagtgg ggctggttgc cagtcagaag     1440

aacgacctgg acgcagtggc actgatgcat cccgatggct ctgctgttgt ggtcgtgcta     1500

aaccgctcct ctaaggatgt gcctcttacc atcaaggatc ctgctgtggg cttcctggag     1560

acaatctcac ctggctactc cattcacacc tacctgtggc gtcgccagtg a              1611


<210>  68
<211>  538
<212>  PRT
<213>  Homo sapiens

<400>  68

Ala Ser Met Glu Phe Ser Ser Pro Ser Arg Glu Glu Cys Pro Lys Pro 
1               5                   10                  15      


Leu Ser Arg Val Ser Ile Met Ala Gly Ser Leu Thr Gly Leu Leu Leu 
            20                  25                  30          


Leu Gln Ala Val Ser Trp Ala Ser Gly Ala Arg Pro Cys Ile Pro Lys 
        35                  40                  45              


Ser Phe Gly Tyr Ser Ser Val Val Cys Val Cys Asn Ala Thr Tyr Cys 
    50                  55                  60                  


Asp Ser Phe Asp Pro Pro Thr Phe Pro Ala Leu Gly Thr Phe Ser Arg 
65                  70                  75                  80  


Tyr Glu Ser Thr Arg Ser Gly Arg Arg Met Glu Leu Ser Met Gly Pro 
                85                  90                  95      


Ile Gln Ala Asn His Thr Gly Thr Gly Leu Leu Leu Thr Leu Gln Pro 
            100                 105                 110         


Glu Gln Lys Phe Gln Lys Val Lys Gly Phe Gly Gly Ala Met Thr Asp 
        115                 120                 125             


Ala Ala Ala Leu Asn Ile Leu Ala Leu Ser Pro Pro Ala Gln Asn Leu 
    130                 135                 140                 


Leu Leu Lys Ser Tyr Phe Ser Glu Glu Gly Ile Gly Tyr Asn Ile Ile 
145                 150                 155                 160 


Arg Val Pro Met Ala Ser Ser Asp Phe Ser Ile Arg Thr Tyr Thr Tyr 
                165                 170                 175     


Ala Asp Thr Pro Asp Asp Phe Gln Leu His Asn Phe Ser Leu Pro Glu 
            180                 185                 190         


Glu Asp Thr Lys Leu Lys Ile Pro Leu Ile His Arg Ala Leu Gln Leu 
        195                 200                 205             


Ala Gln Arg Pro Val Ser Leu Leu Ala Ser Pro Trp Thr Ser Pro Thr 
    210                 215                 220                 


Trp Leu Lys Thr Asn Gly Ala Val Asn Gly Lys Gly Ser Leu Lys Gly 
225                 230                 235                 240 


Gln Pro Gly Asp Ile Tyr His Gln Thr Trp Ala Arg Tyr Phe Val Lys 
                245                 250                 255     


Phe Leu Asp Ala Tyr Ala Glu His Lys Leu Gln Phe Trp Ala Val Thr 
            260                 265                 270         


Ala Glu Asn Glu Pro Ser Ala Gly Leu Leu Ser Gly Tyr Pro Phe Gln 
        275                 280                 285             


Ser Leu Gly Phe Thr Pro Glu His Gln Arg Asp Phe Ile Ala Arg Asp 
    290                 295                 300                 


Leu Gly Pro Thr Leu Ala Asn Ser Thr His His Asn Val Arg Leu Leu 
305                 310                 315                 320 


Met Leu Asp Asp Gln Arg Leu Leu Leu Pro His Trp Ala Lys Val Val 
                325                 330                 335     


Leu Thr Asp Pro Glu Ala Ala Lys Tyr Val His Gly Ile Ala Val His 
            340                 345                 350         


Trp Tyr Leu Asp Phe Leu Ala Pro Ala Lys Ala Thr Leu Gly Glu Thr 
        355                 360                 365             


His Arg Leu Phe Pro Asn Thr Met Leu Phe Ala Ser Glu Ala Ser Val 
    370                 375                 380                 


Gly Ser Lys Phe Trp Glu Gln Ser Val Arg Leu Gly Ser Trp Asp Arg 
385                 390                 395                 400 


Gly Met Gln Tyr Ser His Ser Ile Ile Thr Asn Leu Leu Tyr His Val 
                405                 410                 415     


Val Gly Trp Thr Asp Trp Asn Leu Ala Leu Asn Pro Glu Gly Gly Pro 
            420                 425                 430         


Asn Trp Val Arg Asn Phe Val Asp Ser Pro Ile Ile Val Asp Ile Thr 
        435                 440                 445             


Lys Asp Thr Phe Tyr Lys Gln Pro Met Phe Tyr His Leu Gly His Phe 
    450                 455                 460                 


Ser Lys Phe Ile Pro Glu Gly Ser Gln Arg Val Gly Leu Val Ala Ser 
465                 470                 475                 480 


Gln Lys Asn Asp Leu Asp Ala Val Ala Leu Met His Pro Asp Gly Ser 
                485                 490                 495     


Ala Val Val Val Val Leu Asn Arg Ser Ser Lys Asp Val Pro Leu Thr 
            500                 505                 510         


Ile Lys Asp Pro Ala Val Gly Phe Leu Glu Thr Ile Ser Pro Gly Tyr 
        515                 520                 525             


Ser Ile His Thr Tyr Leu Trp Arg Arg Gln 
    530                 535             


<210>  69
<211>  1320
<212>  DNA
<213>  Homo sapiens

<400>  69
atgcagctga ggaacccaga actacatctg ggctgcgcgc ttgcgcttcg cttcctggcc       60

ctcgtttcct gggacatccc tggggctaga gcactggaca atggattggc aaggacgcct      120

accatgggct ggctgcactg ggagcgcttc atgtgcaacc ttgactgcca ggaagagcca      180

gattcctgca tcagtgagaa gctcttcatg gagatggcag agctcatggt ctcagaaggc      240

tggaaggatg caggttatga gtacctctgc attgatgact gttggatggc tccccaaaga      300

gattcagaag gcagacttca ggcagaccct cagcgctttc ctcatgggat tcgccagcta      360

gctaattatg ttcacagcaa aggactgaag ctagggattt atgcagatgt tgggaataaa      420

acctgcgcag gcttccctgg gagttttgga tactacgaca ttgatgccca gacctttgct      480

gactggggag tagatctgct aaaatttgat ggttgttact gtgacagttt ggaaaatttg      540

gcagatggtt ataagcacat gtccttggcc ctgaatagga ctggcagaag cattgtgtac      600

tcctgtgagt ggcctcttta tatgtggccc tttcaaaagc ccaattatac agaaatccga      660

cagtactgca atcactggcg aaattttgct gacattgatg attcctggaa aagtataaag      720

agtatcttgg actggacatc ttttaaccag gagagaattg ttgatgttgc tggaccaggg      780

ggttggaatg acccagatat gttagtgatt ggcaactttg gcctcagctg gaatcagcaa      840

gtaactcaga tggccctctg ggctatcatg gctgctcctt tattcatgtc taatgacctc      900

cgacacatca gccctcaagc caaagctctc cttcaggata aggacgtaat tgccatcaat      960

caggacccct tgggcaagca agggtaccag cttagacagg gagacaactt tgaagtgtgg     1020

gaacgacctc tctcaggctt agcctgggct gtagctatga taaaccggca ggagattggt     1080

ggacctcgct cttataccat cgcagttgct tccctgggta aaggagtggc ctgtaatcct     1140

gcctgcttca tcacacagct cctccctgtg aaaaggaagc tagggttcta tgaatggact     1200

tcaaggttaa gaagtcacat aaatcccaca ggcactgttt tgcttcagct agaaaataca     1260

atgcagatgt cattaaaaga cttactttaa atgcagatgt cattaaaaga cttactttaa     1320


<210>  70
<211>  429
<212>  PRT
<213>  Homo sapiens

<400>  70

Met Gln Leu Arg Asn Pro Glu Leu His Leu Gly Cys Ala Leu Ala Leu 
1               5                   10                  15      


Arg Phe Leu Ala Leu Val Ser Trp Asp Ile Pro Gly Ala Arg Ala Leu 
            20                  25                  30          


Asp Asn Gly Leu Ala Arg Thr Pro Thr Met Gly Trp Leu His Trp Glu 
        35                  40                  45              


Arg Phe Met Cys Asn Leu Asp Cys Gln Glu Glu Pro Asp Ser Cys Ile 
    50                  55                  60                  


Ser Glu Lys Leu Phe Met Glu Met Ala Glu Leu Met Val Ser Glu Gly 
65                  70                  75                  80  


Trp Lys Asp Ala Gly Tyr Glu Tyr Leu Cys Ile Asp Asp Cys Trp Met 
                85                  90                  95      


Ala Pro Gln Arg Asp Ser Glu Gly Arg Leu Gln Ala Asp Pro Gln Arg 
            100                 105                 110         


Phe Pro His Gly Ile Arg Gln Leu Ala Asn Tyr Val His Ser Lys Gly 
        115                 120                 125             


Leu Lys Leu Gly Ile Tyr Ala Asp Val Gly Asn Lys Thr Cys Ala Gly 
    130                 135                 140                 


Phe Pro Gly Ser Phe Gly Tyr Tyr Asp Ile Asp Ala Gln Thr Phe Ala 
145                 150                 155                 160 


Asp Trp Gly Val Asp Leu Leu Lys Phe Asp Gly Cys Tyr Cys Asp Ser 
                165                 170                 175     


Leu Glu Asn Leu Ala Asp Gly Tyr Lys His Met Ser Leu Ala Leu Asn 
            180                 185                 190         


Arg Thr Gly Arg Ser Ile Val Tyr Ser Cys Glu Trp Pro Leu Tyr Met 
        195                 200                 205             


Trp Pro Phe Gln Lys Pro Asn Tyr Thr Glu Ile Arg Gln Tyr Cys Asn 
    210                 215                 220                 


His Trp Arg Asn Phe Ala Asp Ile Asp Asp Ser Trp Lys Ser Ile Lys 
225                 230                 235                 240 


Ser Ile Leu Asp Trp Thr Ser Phe Asn Gln Glu Arg Ile Val Asp Val 
                245                 250                 255     


Ala Gly Pro Gly Gly Trp Asn Asp Pro Asp Met Leu Val Ile Gly Asn 
            260                 265                 270         


Phe Gly Leu Ser Trp Asn Gln Gln Val Thr Gln Met Ala Leu Trp Ala 
        275                 280                 285             


Ile Met Ala Ala Pro Leu Phe Met Ser Asn Asp Leu Arg His Ile Ser 
    290                 295                 300                 


Pro Gln Ala Lys Ala Leu Leu Gln Asp Lys Asp Val Ile Ala Ile Asn 
305                 310                 315                 320 


Gln Asp Pro Leu Gly Lys Gln Gly Tyr Gln Leu Arg Gln Gly Asp Asn 
                325                 330                 335     


Phe Glu Val Trp Glu Arg Pro Leu Ser Gly Leu Ala Trp Ala Val Ala 
            340                 345                 350         


Met Ile Asn Arg Gln Glu Ile Gly Gly Pro Arg Ser Tyr Thr Ile Ala 
        355                 360                 365             


Val Ala Ser Leu Gly Lys Gly Val Ala Cys Asn Pro Ala Cys Phe Ile 
    370                 375                 380                 


Thr Gln Leu Leu Pro Val Lys Arg Lys Leu Gly Phe Tyr Glu Trp Thr 
385                 390                 395                 400 


Ser Arg Leu Arg Ser His Ile Asn Pro Thr Gly Thr Val Leu Leu Gln 
                405                 410                 415     


Leu Glu Asn Thr Met Gln Met Ser Leu Lys Asp Leu Leu 
            420                 425                 


<210>  71
<211>  92
<212>  PRT
<213>  Homo sapiens

<400>  71

Met Gln Pro Ser Ser Leu Leu Pro Leu Ala Leu Cys Leu Leu Ala Ala 
1               5                   10                  15      


Pro Ala Gly Ser Ser Lys Pro Gln Ala Leu Ala Thr Pro Asn Lys Glu 
            20                  25                  30          


Glu His Gly Lys Arg Lys Lys Lys Gly Lys Gly Leu Gly Lys Lys Arg 
        35                  40                  45              


Asp Pro Cys Leu Arg Lys Tyr Lys Asp Phe Cys Ile His Gly Glu Cys 
    50                  55                  60                  


Lys Tyr Val Lys Glu Leu Arg Ala Pro Ser Cys Ile Cys His Pro Gly 
65                  70                  75                  80  


Tyr His Gly Glu Arg Cys His Gly Leu Ser Gly Ser 
                85                  90          


<210>  72
<211>  47
<212>  PRT
<213>  Homo sapiens

<400>  72

Met Gln Pro Ser Ser Leu Leu Pro Leu Ala Leu Cys Leu Leu Ala Ala 
1               5                   10                  15      


Pro Ala Gly Ser Gly Lys Arg Lys Lys Lys Gly Lys Gly Leu Gly Lys 
            20                  25                  30          


Lys Arg Asp Pro Ser Leu Arg Lys Tyr Lys Asp Phe Ser Gly Ser 
        35                  40                  45          


<210>  73
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  N-terminal Linker

<400>  73
agatccgtcg acatcgaagg tagcggcatt                                        30


<210>  74
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  N-terminal Linker

<400>  74
ggatccgtcg acatcgaagg tagcggcatt                                        30


