                         SEQUENCE LISTING

<110>  Case Western Reserve University
 
<120>  INSULIN ANALOGUES WITH CHLORINATED AMINO ACIDS

<130>  200512.00116

<150>  61/285,955
<151>  2009-12-11

<160>  16    

<170>  PatentIn version 3.5

<210>  1
<211>  86
<212>  PRT
<213>  HomoSapiens

<400>  1

Phe Val Asn Gln His Leu Cys Gly Ser His Leu Val Glu Ala Leu Tyr 
1               5                   10                  15      


Leu Val Cys Gly Glu Arg Gly Phe Phe Tyr Thr Pro Lys Thr Arg Arg 
            20                  25                  30          


Glu Ala Glu Asp Leu Gln Val Gly Gln Val Glu Leu Gly Gly Gly Pro 
        35                  40                  45              


Gly Ala Gly Ser Leu Gln Pro Leu Ala Leu Glu Gly Ser Leu Gln Lys 
    50                  55                  60                  


Arg Gly Ile Val Glu Gln Cys Cys Thr Ser Ile Cys Ser Leu Tyr Gln 
65                  70                  75                  80  


Leu Glu Asn Tyr Cys Asn 
                85      


<210>  2
<211>  21
<212>  PRT
<213>  HomoSapiens

<400>  2

Gly Ile Val Glu Gln Cys Cys Thr Ser Ile Cys Ser Leu Tyr Gln Leu 
1               5                   10                  15      


Glu Asn Tyr Cys Asn 
            20      


<210>  3
<211>  30
<212>  PRT
<213>  HomoSapiens

<400>  3

Phe Val Asn Gln His Leu Cys Gly Ser His Leu Val Glu Ala Leu Tyr 
1               5                   10                  15      


Leu Val Cys Gly Glu Arg Gly Phe Phe Tyr Thr Pro Lys Thr 
            20                  25                  30  


<210>  4
<211>  30
<212>  PRT
<213>  HomoSapiens


<220>
<221>  MISC_FEATURE
<222>  (24)..(24)
<223>  Xaa=Phe or 4Cl-Phe

<400>  4

Phe Val Asn Gln His Leu Cys Gly Ser His Leu Val Glu Ala Leu Tyr 
1               5                   10                  15      


Leu Val Cys Gly Glu Arg Gly Xaa Phe Tyr Thr Lys Pro Thr 
            20                  25                  30  


<210>  5
<211>  30
<212>  PRT
<213>  HomoSapiens


<220>
<221>  MISC_FEATURE
<222>  (24)..(24)
<223>  Xaa=Phe or 4Cl-Phe

<400>  5

Phe Val Asn Gln His Leu Cys Gly Ser His Leu Val Glu Ala Leu Tyr 
1               5                   10                  15      


Leu Val Cys Gly Glu Arg Gly Xaa Phe Tyr Thr Asp Lys Thr 
            20                  25                  30  


<210>  6
<211>  52
<212>  PRT
<213>  HomoSapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Xaa=His or Phe

<220>
<221>  MISC_FEATURE
<222>  (24)..(24)
<223>  Xaa=Phe or 4Cl-Phe

<220>
<221>  MISC_FEATURE
<222>  (26)..(26)
<223>  Xaa=Tyr or Phe

<220>
<221>  MISC_FEATURE
<222>  (28)..(28)
<223>  Xaa=Pro, Lys or Asp

<220>
<221>  MISC_FEATURE
<222>  (29)..(29)
<223>  Xaa=Lys or Pro

<220>
<221>  MISC_FEATURE
<222>  (31)..(31)
<223>  Xaa=0-35 of any amino acid or a break in the amino acid chain

<220>
<221>  MISC_FEATURE
<222>  (35)..(35)
<223>  Xaa=His or Glu

<220>
<221>  MISC_FEATURE
<222>  (39)..(39)
<223>  Xaa=His or Thr

<400>  6

Xaa Val Asn Gln His Leu Cys Gly Ser His Leu Val Glu Ala Leu Tyr 
1               5                   10                  15      


Leu Val Cys Gly Glu Arg Gly Xaa Phe Xaa Thr Xaa Xaa Thr Xaa Gly 
            20                  25                  30          


Ile Val Xaa Gln Cys Cys Xaa Ser Ile Cys Ser Leu Tyr Gln Leu Glu 
        35                  40                  45              


Asn Tyr Cys Asn 
    50          


<210>  7
<211>  21
<212>  PRT
<213>  HomoSapiens


<220>
<221>  MISC_FEATURE
<222>  (8)..(8)
<223>  Xaa=His, Arg or Lys

<400>  7

Gly Ile Val Glu Gln Cys Cys Xaa Ser Ile Cys Ser Leu Tyr Gln Leu 
1               5                   10                  15      


Glu Asn Tyr Cys Asn 
            20      


<210>  8
<211>  30
<212>  PRT
<213>  HomoSapiens


<220>
<221>  MISC_FEATURE
<222>  (24)..(24)
<223>  Xaa=Phe or 4Cl-Phe

<400>  8

Phe Val Asn Gln His Leu Cys Gly Ser Asp Leu Val Glu Ala Leu Tyr 
1               5                   10                  15      


Leu Val Cys Gly Glu Arg Gly Xaa Phe Thr Thr Lys Pro Thr 
            20                  25                  30  


<210>  9
<211>  8
<212>  PRT
<213>  HomoSapiens


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa=Phe or 4Cl-Phe

<400>  9

Gly Xaa Phe Tyr Thr Lys Pro Thr 
1               5               


<210>  10
<211>  8
<212>  PRT
<213>  HomoSapiens

<400>  10

Gly Phe Phe Tyr Thr Pro Lys Thr 
1               5               


<210>  11
<211>  90
<212>  DNA
<213>  HomoSapiens

<400>  11
tttgtgaacc aacacctgtg cggctcacac ctggtggaag ctctctacct agtgtgcggg       60

gaacgaggct agttctacac acccaagacc                                        90


<210>  12
<211>  90
<212>  DNA
<213>  HomoSapiens

<400>  12
tttgttaacc aacatttgtg tggttctcat ttggttgaag ctttgtactt ggtttgtggt       60

gaaagaggtt agttttacac tccaaagact                                        90


<210>  13
<211>  261
<212>  DNA
<213>  HomoSapiens

<400>  13
tttgtgaacc aacacctgtg cggctcacac ctggtggaag ctctctacct agtgtgcggg       60

gaacgaggct agttctacac acccaagacc cgccgggagg cagaggacct gcaggtgggg      120

caggtggagc tgggcggcgg ccctggtgca ggcagcctgc agcccttggc cctggagggg      180

tccctgcaga agcgtggcat tgtggaacaa tgctgtacca gcatctgctc cctctaccag      240

ctggagaact actgcaacta g                                                261


<210>  14
<211>  261
<212>  DNA
<213>  HomoSapiens

<400>  14
tttgttaacc aacatttgtg tggttctcat ttggttgaag ctttgtactt ggtttgtggt       60

gaaagaggtt agttttacac tccaaagact agaagagaag ctgaagattt gcaagttggt      120

caagttgaat tgggtggtgg tccaggtgct ggttctttgc aaccattggc tttggaaggt      180

tctttgcaaa agagaggtat tgttgaacaa tgttgtactt ctatttgttc tttgtaccaa      240

ttggaaaact actgtaacta a                                                261


<210>  15
<211>  22
<212>  PRT
<213>  HomoSapiens

<400>  15

Phe Val Asn Gln His Leu Cys Gly Ser His Leu Val Glu Ala Leu Tyr 
1               5                   10                  15      


Leu Val Cys Gly Glu Arg 
            20          


<210>  16
<211>  8
<212>  PRT
<213>  HomoSapiens


<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  Xaa=F-Phe

<400>  16

Gly Phe Phe Xaa Thr Lys Pro Thr 
1               5               


