
                                SEQUENCE LISTING

<110> aTyr Pharma Inc.
      Watkins, Jeffry Dean
      Vasserot, Alain P.
      Greene, Leslie Ann
      Adams, Ryan Andrew
      Chiang, Kyle P.
      Zhang, Wei
      Piehl, Kristi Helen
      Hong, Fei
      He, Alina
      

<120> AMINO ACYL-TRNA SYNTHETASES FOR
  MODULATING INFLAMMATION
  

<130> 120161.420PC

<140> PCT
<141> 2010-12-10

<150> US 61/285,913                  
<151> 2009-12-11 

<150> US 61/285,923
<151> 2009-12-11

<150> US 61/285,919
<151> 2009-12-11 

<160> 117

<170> FastSEQ for Windows Version 4.0

<210> 1
<211> 528
<212> PRT
<213> Homo sapiens

<400> 1
Met Gly Asp Ala Pro Ser Pro Glu Glu Lys Leu His Leu Ile Thr Arg
 1               5                  10                  15      
Asn Leu Gln Glu Val Leu Gly Glu Glu Lys Leu Lys Glu Ile Leu Lys
            20                  25                  30          
Glu Arg Glu Leu Lys Ile Tyr Trp Gly Thr Ala Thr Thr Gly Lys Pro
        35                  40                  45              
His Val Ala Tyr Phe Val Pro Met Ser Lys Ile Ala Asp Phe Leu Lys
    50                  55                  60                  
Ala Gly Cys Glu Val Thr Ile Leu Phe Ala Asp Leu His Ala Tyr Leu
65                  70                  75                  80  
Asp Asn Met Lys Ala Pro Trp Glu Leu Leu Glu Leu Arg Val Ser Tyr
                85                  90                  95      
Tyr Glu Asn Val Ile Lys Ala Met Leu Glu Ser Ile Gly Val Pro Leu
            100                 105                 110         
Glu Lys Leu Lys Phe Ile Lys Gly Thr Asp Tyr Gln Leu Ser Lys Glu
        115                 120                 125             
Tyr Thr Leu Asp Val Tyr Arg Leu Ser Ser Val Val Thr Gln His Asp
    130                 135                 140                 
Ser Lys Lys Ala Gly Ala Glu Val Val Lys Gln Val Glu His Pro Leu
145                 150                 155                 160 
Leu Ser Gly Leu Leu Tyr Pro Gly Leu Gln Ala Leu Asp Glu Glu Tyr
                165                 170                 175     
Leu Lys Val Asp Ala Gln Phe Gly Gly Ile Asp Gln Arg Lys Ile Phe
            180                 185                 190         
Thr Phe Ala Glu Lys Tyr Leu Pro Ala Leu Gly Tyr Ser Lys Arg Val
        195                 200                 205             
His Leu Met Asn Pro Met Val Pro Gly Leu Thr Gly Ser Lys Met Ser
    210                 215                 220                 
Ser Ser Glu Glu Glu Ser Lys Ile Asp Leu Leu Asp Arg Lys Glu Asp
225                 230                 235                 240 
Val Lys Lys Lys Leu Lys Lys Ala Phe Cys Glu Pro Gly Asn Val Glu
                245                 250                 255     
Asn Asn Gly Val Leu Ser Phe Ile Lys His Val Leu Phe Pro Leu Lys
            260                 265                 270         
Ser Glu Phe Val Ile Leu Arg Asp Glu Lys Trp Gly Gly Asn Lys Thr
        275                 280                 285             
Tyr Thr Ala Tyr Val Asp Leu Glu Lys Asp Phe Ala Ala Glu Val Val
    290                 295                 300                 
His Pro Gly Asp Leu Lys Asn Ser Val Glu Val Ala Leu Asn Lys Leu
305                 310                 315                 320 
Leu Asp Pro Ile Arg Glu Lys Phe Asn Thr Pro Ala Leu Lys Lys Leu
                325                 330                 335     
Ala Ser Ala Ala Tyr Pro Asp Pro Ser Lys Gln Lys Pro Met Ala Lys
            340                 345                 350         
Gly Pro Ala Lys Asn Ser Glu Pro Glu Glu Val Ile Pro Ser Arg Leu
        355                 360                 365             
Asp Ile Arg Val Gly Lys Ile Ile Thr Val Glu Lys His Pro Asp Ala
    370                 375                 380                 
Asp Ser Leu Tyr Val Glu Lys Ile Asp Val Gly Glu Ala Glu Pro Arg
385                 390                 395                 400 
Thr Val Val Ser Gly Leu Val Gln Phe Val Pro Lys Glu Glu Leu Gln
                405                 410                 415     
Asp Arg Leu Val Val Val Leu Cys Asn Leu Lys Pro Gln Lys Met Arg
            420                 425                 430         
Gly Val Glu Ser Gln Gly Met Leu Leu Cys Ala Ser Ile Glu Gly Ile
        435                 440                 445             
Asn Arg Gln Val Glu Pro Leu Asp Pro Pro Ala Gly Ser Ala Pro Gly
    450                 455                 460                 
Glu His Val Phe Val Lys Gly Tyr Glu Lys Gly Gln Pro Asp Glu Glu
465                 470                 475                 480 
Leu Lys Pro Lys Lys Lys Val Phe Glu Lys Leu Gln Ala Asp Phe Lys
                485                 490                 495     
Ile Ser Glu Glu Cys Ile Ala Gln Trp Lys Gln Thr Asn Phe Met Thr
            500                 505                 510         
Lys Leu Gly Ser Ile Ser Cys Lys Ser Leu Lys Gly Gly Asn Ile Ser
        515                 520                 525             


<210> 2
<211> 528
<212> PRT
<213> Homo sapiens

<400> 2
Met Gly Asp Ala Pro Ser Pro Glu Glu Lys Leu His Leu Ile Thr Arg
 1               5                  10                  15      
Asn Leu Gln Glu Val Leu Gly Glu Glu Lys Leu Lys Glu Ile Leu Lys
            20                  25                  30          
Glu Arg Glu Leu Lys Ile Tyr Trp Gly Thr Ala Thr Thr Gly Lys Pro
        35                  40                  45              
His Val Ala Tyr Phe Val Pro Met Ser Lys Ile Ala Asp Phe Leu Lys
    50                  55                  60                  
Ala Gly Cys Glu Val Thr Ile Leu Phe Ala Asp Leu His Ala Tyr Leu
65                  70                  75                  80  
Asp Asn Met Lys Ala Pro Trp Glu Leu Leu Glu Leu Arg Val Ser Tyr
                85                  90                  95      
Tyr Glu Asn Val Ile Lys Ala Met Leu Glu Ser Ile Gly Val Pro Leu
            100                 105                 110         
Glu Lys Leu Lys Phe Ile Lys Gly Thr Asp Tyr Gln Leu Ser Lys Glu
        115                 120                 125             
Tyr Thr Leu Asp Val Tyr Arg Leu Ser Ser Val Val Thr Gln His Asp
    130                 135                 140                 
Ser Lys Lys Ala Gly Ala Glu Val Val Lys Gln Val Glu His Pro Leu
145                 150                 155                 160 
Leu Ser Gly Leu Leu Tyr Pro Gly Leu Gln Ala Leu Asp Glu Glu Tyr
                165                 170                 175     
Leu Lys Val Asp Ala Gln Phe Gly Gly Ile Asp Gln Arg Lys Ile Phe
            180                 185                 190         
Thr Phe Ala Glu Lys Tyr Leu Pro Ala Leu Gly Tyr Ser Lys Arg Val
        195                 200                 205             
His Leu Met Asn Pro Met Val Pro Gly Leu Thr Gly Ser Lys Met Ser
    210                 215                 220                 
Ser Ser Glu Glu Glu Ser Lys Ile Asp Leu Leu Asp Arg Lys Glu Asp
225                 230                 235                 240 
Val Lys Lys Lys Leu Lys Lys Ala Phe Cys Glu Pro Gly Asn Val Glu
                245                 250                 255     
Asn Asn Gly Val Leu Ser Phe Ile Lys His Val Leu Phe Pro Leu Lys
            260                 265                 270         
Ser Glu Phe Val Ile Leu Arg Asp Glu Lys Trp Gly Gly Asn Lys Thr
        275                 280                 285             
Tyr Thr Ala Tyr Val Asp Leu Glu Lys Asp Phe Ala Ala Glu Val Val
    290                 295                 300                 
His Pro Gly Asp Leu Lys Asn Ser Val Glu Val Ala Leu Asn Lys Leu
305                 310                 315                 320 
Leu Asp Pro Ile Arg Glu Lys Phe Asn Thr Pro Ala Leu Lys Lys Leu
                325                 330                 335     
Ala Ser Ala Ala Ala Pro Asp Pro Ser Lys Gln Lys Pro Met Ala Lys
            340                 345                 350         
Gly Pro Ala Lys Asn Ser Glu Pro Glu Glu Val Ile Pro Ser Arg Leu
        355                 360                 365             
Asp Ile Arg Val Gly Lys Ile Ile Thr Val Glu Lys His Pro Asp Ala
    370                 375                 380                 
Asp Ser Leu Tyr Val Glu Lys Ile Asp Val Gly Glu Ala Glu Pro Arg
385                 390                 395                 400 
Thr Val Val Ser Gly Leu Val Gln Phe Val Pro Lys Glu Glu Leu Gln
                405                 410                 415     
Asp Arg Leu Val Val Val Leu Cys Asn Leu Lys Pro Gln Lys Met Arg
            420                 425                 430         
Gly Val Glu Ser Gln Gly Met Leu Leu Cys Ala Ser Ile Glu Gly Ile
        435                 440                 445             
Asn Arg Gln Val Glu Pro Leu Asp Pro Pro Ala Gly Ser Ala Pro Gly
    450                 455                 460                 
Glu His Val Phe Val Lys Gly Tyr Glu Lys Gly Gln Pro Asp Glu Glu
465                 470                 475                 480 
Leu Lys Pro Lys Lys Lys Val Phe Glu Lys Leu Gln Ala Asp Phe Lys
                485                 490                 495     
Ile Ser Glu Glu Cys Ile Ala Gln Trp Lys Gln Thr Asn Phe Met Thr
            500                 505                 510         
Lys Leu Gly Ser Ile Ser Cys Lys Ser Leu Lys Gly Gly Asn Ile Ser
        515                 520                 525             


<210> 3
<211> 364
<212> PRT
<213> Homo sapiens

<400> 3
Met Gly Asp Ala Pro Ser Pro Glu Glu Lys Leu His Leu Ile Thr Arg
 1               5                  10                  15      
Asn Leu Gln Glu Val Leu Gly Glu Glu Lys Leu Lys Glu Ile Leu Lys
            20                  25                  30          
Glu Arg Glu Leu Lys Ile Tyr Trp Gly Thr Ala Thr Thr Gly Lys Pro
        35                  40                  45              
His Val Ala Tyr Phe Val Pro Met Ser Lys Ile Ala Asp Phe Leu Lys
    50                  55                  60                  
Ala Gly Cys Glu Val Thr Ile Leu Phe Ala Asp Leu His Ala Tyr Leu
65                  70                  75                  80  
Asp Asn Met Lys Ala Pro Trp Glu Leu Leu Glu Leu Arg Val Ser Tyr
                85                  90                  95      
Tyr Glu Asn Val Ile Lys Ala Met Leu Glu Ser Ile Gly Val Pro Leu
            100                 105                 110         
Glu Lys Leu Lys Phe Ile Lys Gly Thr Asp Tyr Gln Leu Ser Lys Glu
        115                 120                 125             
Tyr Thr Leu Asp Val Tyr Arg Leu Ser Ser Val Val Thr Gln His Asp
    130                 135                 140                 
Ser Lys Lys Ala Gly Ala Glu Val Val Lys Gln Val Glu His Pro Leu
145                 150                 155                 160 
Leu Ser Gly Leu Leu Tyr Pro Gly Leu Gln Ala Leu Asp Glu Glu Tyr
                165                 170                 175     
Leu Lys Val Asp Ala Gln Phe Gly Gly Ile Asp Gln Arg Lys Ile Phe
            180                 185                 190         
Thr Phe Ala Glu Lys Tyr Leu Pro Ala Leu Gly Tyr Ser Lys Arg Val
        195                 200                 205             
His Leu Met Asn Pro Met Val Pro Gly Leu Thr Gly Ser Lys Met Ser
    210                 215                 220                 
Ser Ser Glu Glu Glu Ser Lys Ile Asp Leu Leu Asp Arg Lys Glu Asp
225                 230                 235                 240 
Val Lys Lys Lys Leu Lys Lys Ala Phe Cys Glu Pro Gly Asn Val Glu
                245                 250                 255     
Asn Asn Gly Val Leu Ser Phe Ile Lys His Val Leu Phe Pro Leu Lys
            260                 265                 270         
Ser Glu Phe Val Ile Leu Arg Asp Glu Lys Trp Gly Gly Asn Lys Thr
        275                 280                 285             
Tyr Thr Ala Tyr Val Asp Leu Glu Lys Asp Phe Ala Ala Glu Val Val
    290                 295                 300                 
His Pro Gly Asp Leu Lys Asn Ser Val Glu Val Ala Leu Asn Lys Leu
305                 310                 315                 320 
Leu Asp Pro Ile Arg Glu Lys Phe Asn Thr Pro Ala Leu Lys Lys Leu
                325                 330                 335     
Ala Ser Ala Ala Tyr Pro Asp Pro Ser Lys Gln Lys Pro Met Ala Lys
            340                 345                 350         
Gly Pro Ala Lys Asn Ser Glu Pro Glu Glu Val Ile
        355                 360                 


<210> 4
<211> 1683
<212> DNA
<213> Homo sapiens

<400> 4
atgggggacg ctcccagccc tgaagagaaa ctgcacctta tcacccggaa cctgcaggag 60
gttctggggg aagagaagct gaaggagata ctgaaggagc gggaacttaa aatttactgg 120
ggaacggcaa ccacgggcaa accacatgtg gcttactttg tgcccatgtc aaagattgca 180
gacttcttaa aggcagggtg tgaggtaaca attctgtttg cggacctcca cgcatacctg 240
gataacatga aagccccatg ggaacttcta gaactccgag tcagttacta tgagaatgtg 300
atcaaagcaa tgctggagag cattggtgtg cccttggaga agctcaagtt catcaaaggc 360
actgattacc agctcagcaa agagtacaca ctagatgtgt acagactctc ctccgtggtc 420
acacagcacg attccaagaa ggctggagct gaggtggtaa agcaggtgga gcaccctttg 480
ctgagtggcc tcttataccc cggactgcag gctttggatg aagagtattt aaaagtagat 540
gcccaatttg gaggcattga tcagagaaag attttcacct ttgcagagaa gtacctccct 600
gcacttggct attcaaaacg ggtccatctg atgaatccta tggttccagg attaacaggc 660
agcaaaatga gctcttcaga agaggagtcc aagattgatc tccttgatcg gaaggaggat 720
gtgaagaaaa aactgaagaa ggccttctgt gagccaggaa atgtggagaa caatggggtt 780
ctgtccttca tcaagcatgt cctttttccc cttaagtccg agtttgtgat cctacgagat 840
gagaaatggg gtggaaacaa aacctacaca gcttacgtgg acctggaaaa ggactttgct 900
gctgaggttg tacatcctgg agacctgaag aattctgttg aagtcgcact gaacaagttg 960
ctggatccaa tccgggaaaa gtttaatacc cctgccctga aaaaactggc cagcgctgcc 1020
tacccagatc cctcaaagca gaagccaatg gccaaaggcc ctgccaagaa ttcagaacca 1080
gaggaggtca tcccatcccg gctggatatc cgtgtgggga aaatcatcac tgtggagaag 1140
cacccagatg cagacagcct gtatgtagag aagattgacg tgggggaagc tgaaccacgg 1200
actgtggtga gcggcctggt acagttcgtg cccaaggagg aactgcagga caggctggta 1260
gtggtgctgt gcaacctgaa accccagaag atgagaggag tcgagtccca aggcatgctt 1320
ctgtgtgctt ctatagaagg gataaaccgc caggttgaac ctctggaccc tccggcaggc 1380
tctgctcctg gtgagcacgt gtttgtgaag ggctatgaaa agggccaacc agatgaggag 1440
ctcaagccca agaagaaagt cttcgagaag ttgcaggctg acttcaaaat ttctgaggag 1500
tgcatcgcac agtggaagca aaccaacttc atgaccaagc tgggctccat ttcctgtaaa 1560
tcgctgaaag gggggaacat tagctagcca gcccagcatc ttcccccctt cttccaccac 1620
tgagtcatct gctgtctctt cagtctgctc catccatcac ccatttaccc atctctcagg 1680
aca                                                               1683

<210> 5
<211> 8
<212> PRT
<213> Artificial Sequence

<220> 
<223> C-terminal tag

<400> 5
Leu Glu His His His His His His
 1               5              


<210> 6
<211> 348
<212> PRT
<213> Homo sapiens

<220> 
<221> VARIANT        
<222> 1, 2, 3, 4, 5, 6, 7, 8, 9
<223> Xaa = Any Amino Acid

<400> 6
Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Lys Ile Phe Thr Phe Ala Glu
 1               5                  10                  15      
Lys Tyr Leu Pro Ala Leu Gly Tyr Ser Lys Arg Val His Leu Met Asn
            20                  25                  30          
Pro Met Val Pro Gly Leu Thr Gly Ser Lys Met Ser Ser Ser Glu Glu
        35                  40                  45              
Glu Ser Lys Ile Asp Leu Leu Asp Arg Lys Glu Asp Val Lys Lys Lys
    50                  55                  60                  
Leu Lys Lys Ala Phe Cys Glu Pro Gly Asn Val Glu Asn Asn Gly Val
65                  70                  75                  80  
Leu Ser Phe Ile Lys His Val Leu Phe Pro Leu Lys Ser Glu Phe Val
                85                  90                  95      
Ile Leu Arg Asp Glu Lys Trp Gly Gly Asn Lys Thr Tyr Thr Ala Tyr
            100                 105                 110         
Val Asp Leu Glu Lys Asp Phe Ala Ala Glu Val Val His Pro Gly Asp
        115                 120                 125             
Leu Lys Asn Ser Val Glu Val Ala Leu Asn Lys Leu Leu Asp Pro Ile
    130                 135                 140                 
Arg Glu Lys Phe Asn Thr Pro Ala Leu Lys Lys Leu Ala Ser Ala Ala
145                 150                 155                 160 
Tyr Pro Asp Pro Ser Lys Gln Lys Pro Met Ala Lys Gly Pro Ala Lys
                165                 170                 175     
Asn Ser Glu Pro Glu Glu Val Ile Pro Ser Arg Leu Asp Ile Arg Val
            180                 185                 190         
Gly Lys Ile Ile Thr Val Glu Lys His Pro Asp Ala Asp Ser Leu Tyr
        195                 200                 205             
Val Glu Lys Ile Asp Val Gly Glu Ala Glu Pro Arg Thr Val Val Ser
    210                 215                 220                 
Gly Leu Val Gln Phe Val Pro Lys Glu Glu Leu Gln Asp Arg Leu Val
225                 230                 235                 240 
Val Val Leu Cys Asn Leu Lys Pro Gln Lys Met Arg Gly Val Glu Ser
                245                 250                 255     
Gln Gly Met Leu Leu Cys Ala Ser Ile Glu Gly Ile Asn Arg Gln Val
            260                 265                 270         
Glu Pro Leu Asp Pro Pro Ala Gly Ser Ala Pro Gly Glu His Val Phe
        275                 280                 285             
Val Lys Gly Tyr Glu Lys Gly Gln Pro Asp Glu Glu Leu Lys Pro Lys
    290                 295                 300                 
Lys Lys Val Phe Glu Lys Leu Gln Ala Asp Phe Lys Ile Ser Glu Glu
305                 310                 315                 320 
Cys Ile Ala Gln Trp Lys Gln Thr Asn Phe Met Thr Lys Leu Gly Ser
                325                 330                 335     
Ile Ser Cys Lys Ser Leu Lys Gly Gly Asn Ile Ser
            340                 345             


<210> 7
<211> 2178
<212> DNA
<213> Homo sapiens

<400> 7
ttcagaaagt ggtggaggga agacttcctt tttcccagag acagaaggtt atgcacccag 60
tggcctggga ccattgttct gggctttttt tcccttcgac atggatttgc ttctcactgt 120
gtaccccaac caccaaaacc accctgagat caatgctggt gctcctgcat cagatggctt 180
agagatcctt ccacctctta acacaagcat ctaggtccac tttactcaaa tctggcctca 240
gttgagagca gagtatacca tcagagccca ttctcctgtc tgctgtctgg gacgtggaaa 300
gaaagttagc tctagggggt ctttccaggg gcctctgtaa ggactggatg ctcctttccg 360
gaatccaaga gttcaccagg ctgcttctct aatggacgat gatcctcttc ctcctgacgt 420
ctctccctgg cagcacccag atgcagacag cctgtatgta gagaagattg acgtggggga 480
agctgaacca cggactgtgg tgagcggcct ggtacagttc gtgcccaagg aggaactgca 540
ggacaggctg gtagtggtgc tgtgcaacct gaaaccccag aagatgagag gagtcgagtc 600
ccaaggcatg cttctgtgtg cttctatgtg agtgaggact tggagtgggg cacaggacct 660
ggggaggcca ggaagagtag ggaatcagcc catatgatgt ccttccacac accaggtgga 720
agctctgaga acacgtgcct cttccttgct gatgccaaaa gttgatgcat gaaggactta 780
tcgtacaagt actgttaatg aagcatttta cctacagtta attttgttaa aatagaaatg 840
gagggctcaa accagtacat acccaagtct tactactagt aaggagtgga gcagggattc 900
aaatcccagt tttgatgtct ataaagtcct cgctacgtta ttttatactt cctcccctag 960
aaacacagat tttggtatct tgacacacaa ttttggtata gcctgggtta atgtaaccct 1020
ggtgatatgc agggatgtag caagataaga ggacctcctg gggctctggt actgaggatg 1080
ccctaaatcc catcagggcc cctgtgtaaa ggcccggatt gctttggcct ccacagtcac 1140
tggaacccat ccatagcctc actcttctct tgtcctgtgt cttcccagag aagggataaa 1200
ccgccaggtt gaacctctgg accctccggc aggctctgct cctggtgagc acgtgtttgt 1260
gaagggctat gaaaagggcc aaccagatga ggagctcaag cccaagagga aagtcttcga 1320
gaagttgcag gctgacttca aaatttctga ggagtgcatc gcacagtgga agcaaaccaa 1380
cttcatgacc aagctgggct ccatttcctg taaatcgctg aaagggggga acattagcta 1440
gccagcccag catcttcccc ccttcttcca ccactgagtc atctgctgtc tcttcagtct 1500
gctccaccca tcacccattt acccatctct caggacacgg aagcagcggg tttggactct 1560
ttattcggtg cagaactcgg caaggggcag cttaccctcc ccagaaccca ggatcatcct 1620
gtctggctgc agtgagagac caacccctaa caagggctgg gccacagcag ggagtccagc 1680
cctaccttct tcccttggca gctggagaaa tctggtttca atataactca tttaaaaatt 1740
tatgccacag tccttataat tggaaaaata ctggtgccca ggttttcttg gagttatcca 1800
agcagctgcg cccctagctg ggatctggta cctggactag gctaattaca gcttctcccc 1860
aacaggaaac tgtgggattt gaaaaggaaa gggaagggaa aacagagaac ctagtggtct 1920
accaagtggt tggcaacttt cccaatgtct gcttactctg aggcttggca ctgggggcca 1980
gggcctgccc cagggctcct ggaatttccc ttgatccagc taggctggga cactccctaa 2040
atcagctgcg tgttgttagc atcaggcaga atgaatggca gagagtgatt ctgtcttcat 2100
agagggtggg gtacttctcc ataaggcatc tcagtcaaat ccccatcact gtcataaatt 2160
caaataaaat gtctgaac                                               2178

<210> 8
<211> 388
<212> PRT
<213> Homo sapiens

<220> 
<221> VARIANT        
<222> 354, 355, 356, 357, 358, 359, 360, 361, 362, 363, 364, 365,
366, 367, 368, 369, 370, 371, 372, 373, 374, 375, 376, 377,
378, 379, 380, 381, 382, 383, 384, 385, 386, 387, 388
<223> Xaa = Any Amino Acid

<400> 8
Met Gly Asp Ala Pro Ser Pro Glu Glu Lys Leu His Leu Ile Thr Arg
 1               5                  10                  15      
Asn Leu Gln Glu Val Leu Gly Glu Glu Lys Leu Lys Glu Ile Leu Lys
            20                  25                  30          
Glu Arg Glu Leu Lys Ile Tyr Trp Gly Thr Ala Thr Thr Gly Lys Pro
        35                  40                  45              
His Val Ala Tyr Phe Val Pro Met Ser Lys Ile Ala Asp Phe Leu Lys
    50                  55                  60                  
Ala Gly Cys Glu Val Thr Ile Leu Phe Ala Asp Leu His Ala Tyr Leu
65                  70                  75                  80  
Asp Asn Met Lys Ala Pro Trp Glu Leu Leu Glu Leu Arg Val Ser Tyr
                85                  90                  95      
Tyr Glu Asn Val Ile Lys Ala Met Leu Glu Ser Ile Gly Val Pro Leu
            100                 105                 110         
Glu Lys Leu Lys Phe Ile Lys Gly Thr Asp Tyr Gln Leu Ser Lys Glu
        115                 120                 125             
Tyr Thr Leu Asp Val Tyr Arg Leu Ser Ser Val Val Thr Gln His Asp
    130                 135                 140                 
Ser Lys Lys Ala Gly Ala Glu Val Val Lys Gln Val Glu His Pro Leu
145                 150                 155                 160 
Leu Ser Gly Leu Leu Tyr Pro Gly Leu Gln Ala Leu Asp Glu Glu Tyr
                165                 170                 175     
Leu Lys Val Asp Ala Gln Phe Gly Gly Ile Asp Gln Arg Lys Ile Phe
            180                 185                 190         
Thr Phe Ala Glu Lys Tyr Leu Pro Ala Leu Gly Tyr Ser Lys Arg Val
        195                 200                 205             
His Leu Met Asn Pro Met Val Pro Gly Leu Thr Gly Ser Lys Met Ser
    210                 215                 220                 
Ser Ser Glu Glu Glu Ser Lys Ile Asp Leu Leu Asp Arg Lys Glu Asp
225                 230                 235                 240 
Val Lys Lys Lys Leu Lys Lys Ala Phe Cys Glu Pro Gly Asn Val Glu
                245                 250                 255     
Asn Asn Gly Val Leu Ser Phe Ile Lys His Val Leu Phe Pro Leu Lys
            260                 265                 270         
Ser Glu Phe Val Ile Leu Arg Asp Glu Lys Trp Gly Gly Asn Lys Thr
        275                 280                 285             
Tyr Thr Ala Tyr Val Asp Leu Glu Lys Asp Phe Ala Ala Glu Val Val
    290                 295                 300                 
His Pro Gly Asp Leu Lys Asn Ser Val Glu Val Ala Leu Asn Lys Leu
305                 310                 315                 320 
Leu Asp Pro Ile Arg Glu Lys Phe Asn Thr Pro Ala Leu Lys Lys Leu
                325                 330                 335     
Ala Ser Ala Ala Tyr Pro Asp Pro Ser Lys Gln Lys Pro Met Ala Lys
            340                 345                 350         
Gly Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa
        355                 360                 365             
Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa
    370                 375                 380                 
Xaa Xaa Xaa Xaa
385             


<210> 9
<211> 1167
<212> DNA
<213> Homo sapiens

<400> 9
atgggggacg ctcccagccc tgaagagaaa ctgcacctta tcacccggaa cctgcaggag 60
gttctggggg aagagaagct gaaggagata ctgaaggagc gggaacttaa aatttactgg 120
ggaacggcaa ccacgggcaa accacatgtg gcttactttg tgcccatgtc aaagattgca 180
gacttcttaa aggcagggtg tgaggtaaca attctgtttg cggacctcca cgcatacctg 240
gataacatga aagccccatg ggaacttcta gaactccgag tcagttacta tgagaatgtg 300
atcaaagcaa tgctggagag cattggtgtg cccttggaga agctcaagtt catcaaaggc 360
actgattacc agctcagcaa agagtacaca ctagatgtgt acagactctc ctccgtggtc 420
acacagcacg attccaagaa ggctggagct gaggtggtaa agcaggtgga gcaccctttg 480
ctgagtggcc tcttataccc cggactgcag gctttggatg aagagtattt aaaagtagat 540
gcccaatttg gaggcattga tcagagaaag attttcacct ttgcagagaa gtacctccct 600
gcacttggct attcaaaacg ggtccatctg atgaatccta tggttccagg attaacaggc 660
agcaaaatga gctcttcaga agaggagtcc aagattgatc tccttgatcg gaaggaggat 720
gtgaagaaaa aactgaagaa ggccttctgt gagccaggaa atgtggagaa caatggggtt 780
ctgtccttca tcaagcatgt cctttttccc cttaagtccg agtttgtgat cctacgagat 840
gagaaatggg gtggaaacaa aacctacaca gcttacgtgg acctggaaaa ggactttgct 900
gctgaggttg tacatcctgg agacctgaag aattctgttg aagtcgcact gaacaagttg 960
ctggatccaa tccgggaaaa gtttaatacc cctgccctga aaaaactggc cagcgctgcc 1020
tacccagatc cctcaaagca gaagccaatg gccaaaggcc tgccaagaat tcagaaccag 1080
aggaggtcat cccatcccgg ctggatatcc gtgtggggaa aatcatcact gtggagaagc 1140
acccagatgc agacagcctg tatgtag                                     1167

<210> 10
<211> 318
<212> PRT
<213> Homo sapiens

<400> 10
Met Asn Pro Met Val Pro Gly Leu Thr Gly Ser Lys Met Ser Ser Ser
 1               5                  10                  15      
Glu Glu Glu Ser Lys Ile Asp Leu Leu Asp Arg Lys Glu Asp Val Lys
            20                  25                  30          
Lys Lys Leu Lys Lys Ala Phe Cys Glu Pro Gly Asn Val Glu Asn Asn
        35                  40                  45              
Gly Val Leu Ser Phe Ile Lys His Val Leu Phe Pro Leu Lys Ser Glu
    50                  55                  60                  
Phe Val Ile Leu Arg Asp Glu Lys Trp Gly Gly Asn Lys Thr Tyr Thr
65                  70                  75                  80  
Ala Tyr Val Asp Leu Glu Lys Asp Phe Ala Ala Glu Val Val His Pro
                85                  90                  95      
Gly Asp Leu Lys Asn Ser Val Glu Val Ala Leu Asn Lys Leu Leu Asp
            100                 105                 110         
Pro Ile Arg Glu Lys Phe Asn Thr Pro Ala Leu Lys Lys Leu Ala Ser
        115                 120                 125             
Ala Ala Tyr Pro Asp Pro Ser Lys Gln Lys Pro Met Ala Lys Gly Pro
    130                 135                 140                 
Ala Lys Asn Ser Glu Pro Glu Glu Val Ile Pro Ser Arg Leu Asp Ile
145                 150                 155                 160 
Arg Val Gly Lys Ile Ile Thr Val Glu Lys His Pro Asp Ala Asp Ser
                165                 170                 175     
Leu Tyr Val Glu Lys Ile Asp Val Gly Glu Ala Glu Pro Arg Thr Val
            180                 185                 190         
Val Ser Gly Leu Val Gln Phe Val Pro Lys Glu Glu Leu Gln Asp Arg
        195                 200                 205             
Leu Val Val Val Leu Cys Asn Leu Lys Pro Gln Lys Met Arg Gly Val
    210                 215                 220                 
Glu Ser Gln Gly Met Leu Leu Cys Ala Ser Ile Glu Gly Ile Asn Arg
225                 230                 235                 240 
Gln Val Glu Pro Leu Asp Pro Pro Ala Gly Ser Ala Pro Gly Glu His
                245                 250                 255     
Val Phe Val Lys Gly Tyr Glu Lys Gly Gln Pro Asp Glu Glu Leu Lys
            260                 265                 270         
Pro Lys Lys Lys Val Phe Glu Lys Leu Gln Ala Asp Phe Lys Ile Ser
        275                 280                 285             
Glu Glu Cys Ile Ala Gln Trp Lys Gln Thr Asn Phe Met Thr Lys Leu
    290                 295                 300                 
Gly Ser Ile Ser Cys Lys Ser Leu Lys Gly Gly Asn Ile Ser
305                 310                 315             


<210> 11
<211> 1736
<212> DNA
<213> Homo sapiens

<400> 11
gaaagatttt cacctttgca gagaagtacc tccctgcact tggctattca aaacgggtcc 60
atctgatgaa tcctatggtt ccaggattaa caggcagcaa aatgagctct tcagaagagg 120
agtccaagat tgatctcctt gatcggaagg aggatgtgaa gaaaaaactg aagaaggcct 180
tctgtgagcc aggaaatgtg gagaacaatg gggttctgtc cttcatcaag catgtccttt 240
ttccccttaa gtccgagttt gtgatcctac gagatgagaa atggggtgga aacaaaacct 300
acacagctta cgtggacctg gaaaaggact ttgctgctga ggttgtacat cctggagacc 360
tgaagaattc tgttgaagtc gcactgaaca agttgctgga tccaatccgg gaaaagttta 420
atacccctgc cctgaaaaaa ctggccagcg ctgcctaccc agatccctca aagcagaagc 480
caatggccaa aggccctgcc aagaattcag aaccagagga ggtcatccca tcccggctgg 540
atatccgtgt ggggaaaatc atcactgtgg agaagcaccc agatgcagac agcctgtatg 600
tagagaagat tgacgtgggg gaagctgaac cacggactgt ggtgagcggc ctggtacagt 660
tcgtgcccaa ggaggaactg caggacaggc tggtagtggt gctgtgcaac ctgaaacccc 720
agaagatgag aggagtcgag tcccaaggca tgcttctgtg tgcttctata gaagggataa 780
accgccaggt tgaacctctg gaccctccgg caggctctgc tcctggtgag cacgtgtttg 840
tgaagggcta tgaaaagggc caaccagatg aggagctcaa gcccaagaag aaagtcttcg 900
agaagttgca ggctgacttc aaaatttctg aggagtgcat cgcacagtgg aagcaaacca 960
acttcatgac caagctgggc tccatttcct gtaaatcgct gaaagggggg aacattagct 1020
agccagccca gcatcttccc cccttcttcc accactgagt catctgctgt ctcttcagtc 1080
tgctccatcc atcacccatt tacccatctc tcaggacacg gaagcagcgg gtttggactc 1140
tttattcggt gcagaactcg gcaaggggca gcttaccctc cccagaaccc aggatcatcc 1200
tgtctggctg cagtgagaga ccaaccccta acaagggctg ggccacagca gggagtccag 1260
ccctaccttc ttcccttggc agctggagaa atctggtttc aatataactc atttaaaaat 1320
ttatgccaca gtccttataa ttggaaaaat actggtgccc aggttttctt ggagttatcc 1380
aagcagctgc gcccctagct gggatctggt acctggacta ggctaattac agcttctccc 1440
caacaggaaa ctgtgggatt tgaaaaggaa agggaaggga aaacagagaa cctagtggtc 1500
taccaagtgg ttggcaactt tcccaatgtc tgcttactct gaggcttggc actgggggcc 1560
agggcctgcc ccagggctcc tggaatttcc cttgatccag ctaggctggg acactcccta 1620
aatcagctgc gtgttgttag catcaggcag aatgaatggc agagagtgat tctgtcttca 1680
tagagggtgg ggtacttctc cataaggcat ctcagtcaaa tccccatcac tgtcat     1736

<210> 12
<211> 179
<212> PRT
<213> Homo sapiens

<400> 12
Met Ala Lys Gly Pro Ala Lys Asn Ser Glu Pro Glu Glu Val Ile Pro
 1               5                  10                  15      
Ser Arg Leu Asp Ile Arg Val Gly Lys Ile Ile Thr Val Glu Lys His
            20                  25                  30          
Pro Asp Ala Asp Ser Leu Tyr Val Glu Lys Ile Asp Val Gly Glu Ala
        35                  40                  45              
Glu Pro Arg Thr Val Val Ser Gly Leu Val Gln Phe Val Pro Lys Glu
    50                  55                  60                  
Glu Leu Gln Asp Arg Leu Val Val Val Leu Cys Asn Leu Lys Pro Gln
65                  70                  75                  80  
Lys Met Arg Gly Val Glu Ser Gln Gly Met Leu Leu Cys Ala Ser Ile
                85                  90                  95      
Glu Gly Ile Asn Arg Gln Val Glu Pro Leu Asp Pro Pro Ala Gly Ser
            100                 105                 110         
Ala Pro Gly Glu His Val Phe Val Lys Gly Tyr Glu Lys Gly Gln Pro
        115                 120                 125             
Asp Glu Glu Leu Lys Pro Lys Lys Lys Val Phe Glu Lys Leu Gln Ala
    130                 135                 140                 
Asp Phe Lys Ile Ser Glu Glu Cys Ile Ala Gln Trp Lys Gln Thr Asn
145                 150                 155                 160 
Phe Met Thr Lys Leu Gly Ser Ile Ser Cys Lys Ser Leu Lys Gly Gly
                165                 170                 175     
Asn Ile Ser
            


<210> 13
<211> 1167
<212> DNA
<213> Homo sapiens

<400> 13
atgggggacg ctcccagccc tgaagagaaa ctgcacctta tcacccggaa cctgcaggag 60
gttctggggg aagagaagct gaaggagata ctgaaggagc gggaacttaa aatttactgg 120
ggaacggcaa ccacgggcaa accacatgtg gcttactttg tgcccatgtc aaagattgca 180
gacttcttaa aggcagggtg tgaggtaaca attctgtttg cggacctcca cgcatacctg 240
gataacatga aagccccatg ggaacttcta gaactccgag tcagttacta tgagaatgtg 300
atcaaagcaa tgctggagag cattggtgtg cccttggaga agctcaagtt catcaaaggc 360
actgattacc agctcagcaa agagtacaca ctagatgtgt acagactctc ctccgtggtc 420
acacagcacg attccaagaa ggctggagct gaggtggtaa agcaggtgga gcaccctttg 480
ctgagtggcc tcttataccc cggactgcag gctttggatg aagagtattt aaaagtagat 540
gcccaatttg gaggcattga tcagagaaag attttcacct ttgcagagaa gtacctccct 600
gcacttggct attcaaaacg ggtccatctg atgaatccta tggttccagg attaacaggc 660
agcaaaatga gctcttcaga agaggagtcc aagattgatc tccttgatcg gaaggaggat 720
gtgaagaaaa aactgaagaa ggccttctgt gagccaggaa atgtggagaa caatggggtt 780
ctgtccttca tcaagcatgt cctttttccc cttaagtccg agtttgtgat cctacgagat 840
gagaaatggg gtggaaacaa aacctacaca gcttacgtgg acctggaaaa ggactttgct 900
gctgaggttg tacatcctgg agacctgaag aattctgttg aagtcgcact gaacaagttg 960
ctggatccaa tccgggaaaa gtttaatacc cctgccctga aaaaactggc cagcgctgcc 1020
tacccagatc cctcaaagca gaagccaatg gccaaaggcc tgccaagaat tcagaaccag 1080
aggaggtcat cccatcccgg ctggatatcc gtgtggggaa aatcatcact gtggagaagc 1140
acccagatgc agacagcctg tatgtag                                     1167

<210> 14
<211> 188
<212> PRT
<213> Homo sapiens

<220> 
<221> VARIANT        
<222> 1, 2, 3, 4, 5, 6, 7, 8
<223> Xaa = Any Amino Acid

<400> 14
Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Pro Met Ala Lys Gly Pro Ala Lys
 1               5                  10                  15      
Asn Ser Glu Pro Glu Glu Val Ile Pro Ser Arg Leu Asp Ile Arg Val
            20                  25                  30          
Gly Lys Ile Ile Thr Val Glu Lys His Pro Asp Ala Asp Ser Leu Tyr
        35                  40                  45              
Val Glu Lys Ile Asp Val Gly Glu Ala Glu Pro Arg Thr Val Val Ser
    50                  55                  60                  
Gly Leu Val Gln Phe Val Pro Lys Glu Glu Leu Gln Asp Arg Leu Val
65                  70                  75                  80  
Val Val Leu Cys Asn Leu Lys Pro Gln Lys Met Arg Gly Val Glu Ser
                85                  90                  95      
Gln Gly Met Leu Leu Cys Ala Ser Ile Glu Gly Ile Asn Arg Gln Val
            100                 105                 110         
Glu Pro Leu Asp Pro Pro Ala Gly Ser Ala Pro Gly Glu His Val Phe
        115                 120                 125             
Val Lys Gly Tyr Glu Lys Gly Gln Pro Asp Glu Glu Leu Lys Pro Lys
    130                 135                 140                 
Lys Lys Val Phe Glu Lys Leu Gln Ala Asp Phe Lys Ile Ser Glu Glu
145                 150                 155                 160 
Cys Ile Ala Gln Trp Lys Gln Thr Asn Phe Met Thr Lys Leu Gly Ser
                165                 170                 175     
Ile Ser Cys Lys Ser Leu Lys Gly Gly Asn Ile Ser
            180                 185             


<210> 15
<211> 2262
<212> DNA
<213> Homo sapiens

<400> 15
gccagacaca gtggctcaca cctgtaatct taacactttg gaaggctgag gcaggcggat 60
cacttgagcc caaaagttag agaccaaaac ccagtctcta cccaaaaaaa aaaaaaaaaa 120
aaaaattagc caggcatagt agcacatgcc tgtagtccca gctacttggg aggctgaggt 180
gagaggatca cctgagcatg gggaagttga gactgcagtg agccatgatc gcaccactgc 240
actccagcct gggcaacaga gtgagactct atgtctcaaa aaaagaaaaa tgatagaaat 300
tagattagac ctattatacc caaccggtat atagggtatc gatagtttct tacacagctg 360
ttgggcagag cctgcagagc ttagagaagc ttatctttag attctcccag tttccttcta 420
tgtgcatggg cctggctctt agttggccat ccacttgtgc gtaatgctaa gatattggca 480
ttgatagctt tgtgcgaccc ttccagaaaa aaactcagta actcagtaaa attttttttt 540
ttttttctaa aagagacaga gtctggctct gttgcccagc ctggtcttga agtcctgggc 600
ttaagcaatc ctcccgtctc agcctcccaa agtgctagaa ttacaggtgt gagctaccac 660
acctggccaa gactcagtaa attctatgtg gaatgcatga atggaaatac ctaaaggagg 720
caaagctact actgctccct ccccgctagt ctaataattg agggagagaa cagatgaaaa 780
tcaggtatgt catgtctgaa aggttgccaa cccagtatta aagaagttac aactcagtgt 840
ttagactctg gggattctac actaaatctt acctaatctc agtgtcttaa cgtggtggga 900
tcagcagctg acctgccaca gggaagaatt ctacctcatg gggttcttct cattcccaga 960
gccaatggcc aaaggccctg ccaagaattc agaaccagag gaggtcatcc catcccggct 1020
ggatatccgt gtggggaaaa tcatcactgt ggagaagcac ccagatgcag acagcctgta 1080
tgtagagaag attgacgtgg gggaagctga accacggact gtggtgagcg gcctggtaca 1140
gttcgtgccc aaggaggaac tgcaggacag gctggtagtg gtgctgtgca acctgaaacc 1200
ccagaagatg agaggagtcg agtcccaagg catgcttctg tgtgcttcta tagaagggat 1260
aaaccgccag gttgaacctc tggaccctcc ggcaggctct gctcctggtg agcacgtgtt 1320
tgtgaagggc tatgaaaagg gccaaccaga tgaggagctc aagcccaaga agaaagtctt 1380
cgagaagttg caggctgact tcaaaatttc tgaggagtgc atcgcacagt ggaagcaaac 1440
caacttcatg accaagctgg gctccatttc ctgtaaatcg ctgaaagggg ggaacattag 1500
ctagccagcc cagcatcttc cccccttctt ccaccactga gtcatctgct gtctcttcag 1560
tctgctccat ccatcaccca tttacccatc tctcaggaca cggaagcagc gggtttggac 1620
tctttattcg gtgcagaact cggcaagggg cagcttaccc tccccagaac ccaggatcat 1680
cctgtctggc tgcagtgaga gaccaacccc taacaagggc tgggccacag cagggagtcc 1740
agccctacct tcttcccttg gcagctggag aaatctggtt tcaatataac tcatttaaaa 1800
atttatgcca cagtccttat aattggaaaa atactggtgc ccaggttttc ttggagttat 1860
ccaagcagct gcgcccctag ctgggatctg gtacctggac taggctaatt acagcttctc 1920
cccaacagga aactgtggga tttgaaaagg aaagggaagg gaaaacagag aacctagtgg 1980
tctaccaagt ggttggcaac tttcccaatg tctgcttact ctgaggcttg gcactggggg 2040
ccagggcctg ccccagggct cctggaattt cccttgatcc agctaggctg ggacactccc 2100
taaatcagct gcgtgttgtt agcatcaggc agaatgaatg gcagagagtg attctgtctt 2160
catagagggt ggggtacttc tccataaggc atctcagtca aatccccatc actgtcataa 2220
attcaaataa aatgtctgaa caagggaaaa aaaaaaaaaa aa                    2262


<210> 16
<211> 685
<212> PRT
<213> Homo sapiens

<400> 16
Met Asp Gly Ala Gly Ala Glu Glu Val Leu Ala Pro Leu Arg Leu Ala
 1               5                  10                  15      
Val Arg Gln Gln Gly Asp Leu Val Arg Lys Leu Lys Glu Asp Lys Ala
            20                  25                  30          
Pro Gln Val Asp Val Asp Lys Ala Val Ala Glu Leu Lys Ala Arg Lys
        35                  40                  45              
Arg Val Leu Glu Ala Lys Glu Leu Ala Leu Gln Pro Lys Asp Asp Ile
    50                  55                  60                  
Val Asp Arg Ala Lys Met Glu Asp Thr Leu Lys Arg Arg Phe Phe Tyr
65                  70                  75                  80  
Asp Gln Ala Phe Ala Ile Tyr Gly Gly Val Ser Gly Leu Tyr Asp Phe
                85                  90                  95      
Gly Pro Val Gly Cys Ala Leu Lys Asn Asn Ile Ile Gln Thr Trp Arg
            100                 105                 110         
Gln His Phe Ile Gln Glu Glu Gln Ile Leu Glu Ile Asp Cys Thr Met
        115                 120                 125             
Leu Thr Pro Glu Pro Val Leu Lys Thr Ser Gly His Val Asp Lys Phe
    130                 135                 140                 
Ala Asp Phe Met Val Lys Asp Val Lys Asn Gly Glu Cys Phe Arg Ala
145                 150                 155                 160 
Asp His Leu Leu Lys Ala His Leu Gln Lys Leu Met Ser Asp Lys Lys
                165                 170                 175     
Cys Ser Val Glu Lys Lys Ser Glu Met Glu Ser Val Leu Ala Gln Leu
            180                 185                 190         
Asp Asn Tyr Gly Gln Gln Glu Leu Ala Asp Leu Phe Val Asn Tyr Asn
        195                 200                 205             
Val Lys Ser Pro Ile Thr Gly Asn Asp Leu Ser Pro Pro Val Ser Phe
    210                 215                 220                 
Asn Leu Met Phe Lys Thr Phe Ile Gly Pro Gly Gly Asn Met Pro Gly
225                 230                 235                 240 
Tyr Leu Arg Pro Glu Thr Ala Gln Gly Ile Phe Leu Asn Phe Lys Arg
                245                 250                 255     
Leu Leu Glu Phe Asn Gln Gly Lys Leu Pro Phe Ala Ala Ala Gln Ile
            260                 265                 270         
Gly Asn Ser Phe Arg Asn Glu Ile Ser Pro Arg Ser Gly Leu Ile Arg
        275                 280                 285             
Val Arg Glu Phe Thr Met Ala Glu Ile Glu His Phe Val Asp Pro Ser
    290                 295                 300                 
Glu Lys Asp His Pro Lys Phe Gln Asn Val Ala Asp Leu His Leu Tyr
305                 310                 315                 320 
Leu Tyr Ser Ala Lys Ala Gln Val Ser Gly Gln Ser Ala Arg Lys Met
                325                 330                 335     
Arg Leu Gly Asp Ala Val Glu Gln Gly Val Ile Asn Asn Thr Val Leu
            340                 345                 350         
Gly Tyr Phe Ile Gly Arg Ile Tyr Leu Tyr Leu Thr Lys Val Gly Ile
        355                 360                 365             
Ser Pro Asp Lys Leu Arg Phe Arg Gln His Met Glu Asn Glu Met Ala
    370                 375                 380                 
His Tyr Ala Cys Asp Cys Trp Asp Ala Glu Ser Lys Thr Ser Tyr Gly
385                 390                 395                 400 
Trp Ile Glu Ile Val Gly Cys Ala Asp Arg Ser Cys Tyr Asp Leu Ser
                405                 410                 415     
Cys His Ala Arg Ala Thr Lys Val Pro Leu Val Ala Glu Lys Pro Leu
            420                 425                 430         
Lys Glu Pro Lys Thr Val Asn Val Val Gln Phe Glu Pro Ser Lys Gly
        435                 440                 445             
Ala Ile Gly Lys Ala Tyr Lys Lys Asp Ala Lys Leu Val Met Glu Tyr
    450                 455                 460                 
Leu Ala Ile Cys Asp Glu Cys Tyr Ile Thr Glu Met Glu Met Leu Leu
465                 470                 475                 480 
Asn Glu Lys Gly Glu Phe Thr Ile Glu Thr Glu Gly Lys Thr Phe Gln
                485                 490                 495     
Leu Thr Lys Asp Met Ile Asn Val Lys Arg Phe Gln Lys Thr Leu Tyr
            500                 505                 510         
Val Glu Glu Val Val Pro Asn Val Ile Glu Pro Ser Phe Gly Leu Gly
        515                 520                 525             
Arg Ile Met Tyr Thr Val Phe Glu His Thr Phe His Val Arg Glu Gly
    530                 535                 540                 
Asp Glu Gln Arg Thr Phe Phe Ser Phe Pro Ala Val Val Ala Pro Phe
545                 550                 555                 560 
Lys Cys Ser Val Leu Pro Leu Ser Gln Asn Gln Glu Phe Met Pro Phe
                565                 570                 575     
Val Lys Glu Leu Ser Glu Ala Leu Thr Arg His Gly Val Ser His Lys
            580                 585                 590         
Val Asp Asp Ser Ser Gly Ser Ile Gly Arg Arg Tyr Ala Arg Thr Asp
        595                 600                 605             
Glu Ile Gly Val Ala Phe Gly Val Thr Ile Asp Phe Asp Thr Val Asn
    610                 615                 620                 
Lys Thr Pro His Thr Ala Thr Leu Arg Asp Arg Asp Ser Met Arg Gln
625                 630                 635                 640 
Ile Arg Ala Glu Ile Ser Glu Leu Pro Ser Ile Val Gln Asp Leu Ala
                645                 650                 655     
Asn Gly Asn Ile Thr Trp Ala Asp Val Glu Ala Arg Tyr Pro Leu Phe
            660                 665                 670         
Glu Gly Gln Glu Thr Gly Lys Lys Glu Thr Ile Glu Glu
        675                 680                 685 


<210> 17
<211> 2058
<212> DNA
<213> Homo sapiens

<400> 17
atggacggcg cgggggctga ggaggtgctg gcacctctga ggctagcagt gcgccagcag 60
ggagatcttg tgcgaaaact caaagaagat aaagcacccc aagtagacgt agacaaagca 120
gtggctgagc tcaaagcccg caagagggtt ctggaagcaa aggagctggc gttacagccc 180
aaagatgata ttgtagaccg agcaaaaatg gaagataccc tgaagaggag gtttttctat 240
gatcaagctt ttgctattta tggaggtgtt agtggtctgt atgactttgg gccagttggc 300
tgtgctttga agaacaatat tattcagacc tggaggcagc actttatcca agaggaacag 360
atcctggaga tcgattgcac catgctcacc cctgagccag ttttaaagac ctctggccat 420
gtagacaaat ttgctgactt catggtgaaa gacgtaaaaa atggagaatg ttttcgtgct 480
gaccatctat taaaagctca tttacagaaa ttgatgtctg ataagaagtg ttctgtcgaa 540
aagaaatcag aaatggaaag tgttttggcc cagcttgata actatggaca gcaagaactt 600
gcggatcttt ttgtgaacta taatgtaaaa tctcccatta ctggaaatga tctatcccct 660
ccagtgtctt ttaacttaat gttcaagact ttcattgggc ctggaggaaa catgcctggg 720
tacttgagac cagaaactgc acaggggatt ttcttgaatt tcaaacgact tttggagttc 780
aaccaaggaa agttgccttt tgctgctgcc cagattggaa attcttttag aaatgagatc 840
tcccctcgat ctggactgat cagagtcaga gaattcacaa tggcagaaat tgagcacttt 900
gtagatccca gtgagaaaga ccaccccaag ttccagaatg tggcagacct tcacctttat 960
ttgtattcag caaaagccca ggtcagcgga cagtccgctc ggaaaatgcg cctgggagat 1020
gctgttgaac agggtgtgat taataacaca gtattaggct atttcattgg ccgcatctac 1080
ctctacctca cgaaggttgg aatatctcca gataaactcc gcttccggca gcacatggag 1140
aatgagatgg cccattatgc ctgtgactgt tgggatgcag aatccaaaac atcctacggt 1200
tggattgaga ttgttggatg tgctgatcgt tcctgttatg acctctcctg tcatgcacga 1260
gccaccaaag tcccacttgt agctgagaaa cctctgaaag aacccaaaac agtcaatgtt 1320
gttcagtttg aacccagtaa gggagcaatt ggtaaggcat ataagaagga tgcaaaactg 1380
gtgatggagt atcttgccat ttgtgatgag tgctacatta cagaaatgga gatgctgctg 1440
aatgagaaag gggaattcac aattgaaact gaagggaaaa catttcagtt aacaaaagac 1500
atgatcaatg tgaagagatt ccagaaaaca ctatatgtgg aagaagttgt tccgaatgta 1560
attgaacctt ccttcggcct gggtaggatc atgtatacgg tatttgaaca tacattccat 1620
gtacgagaag gagatgaaca gagaacattc ttcagtttcc ctgctgtagt tgctccattc 1680
aaatgttccg tcctcccact gagccaaaac caggagttca tgccatttgt caaggaatta 1740
tcggaagccc tgaccaggca tggagtatct cacaaagtag acgattcctc tgggtcaatc 1800
ggaaggcgct atgccaggac tgatgagatt ggcgtggctt ttggtgtcac cattgacttt 1860
gacacagtga acaagacccc ccacactgca actctgaggg accgtgactc aatgcggcag 1920
ataagagcag agatctctga gctgcccagc atagtccaag acctagccaa tggcaacatc 1980
acatgggctg atgtggaggc caggtatcct ctgtttgaag ggcaagagac tggtaaaaaa 2040
gagacaatcg aggaatga                                               2058

<210> 18
<211> 17
<212> PRT
<213> Homo sapiens

<400> 18
Pro Gly Tyr Leu Arg Pro Glu Thr Ala Gln Gly Ile Phe Leu Asn Phe
 1               5                  10                  15      
Lys
    


<210> 19
<211> 16
<212> PRT
<213> Homo sapiens

<400> 19
Thr Gly Asn Asp Leu Ser Pro Pro Val Ser Phe Asn Leu Met Phe Lys
 1               5                  10                  15      


<210> 20
<211> 9
<212> PRT
<213> Homo sapiens

<400> 20
Asn Val Val Gln Phe Glu Pro Ser Lys
 1               5                  


<210> 21
<211> 19
<212> PRT
<213> Homo sapiens

<400> 21
Leu Tyr Val Glu Glu Val Val Pro Asn Val Ile Glu Pro Ser Phe Gly
 1               5                  10                  15      
Leu Gly Arg
            


<210> 22
<211> 20
<212> PRT
<213> Homo sapiens

<400> 22
Ala Ile Tyr Gly Gly Val Ser Gly Leu Tyr Asp Phe Gly Pro Val Gly
 1               5                  10                  15      
Cys Ala Leu Lys
            20  


<210> 23
<211> 15
<212> PRT
<213> Homo sapiens

<400> 23
Gln His Phe Ile Gln Glu Glu Gln Ile Leu Glu Ile Asp Cys Thr
 1               5                  10                  15  


<210> 24

<400> 24
 000

<210> 25
<211> 775
<212> PRT
<213> Homo sapiens

<400> 25
Met Ala Ala Leu Asp Ser Leu Ser Leu Phe Thr Ser Leu Gly Leu Ser
 1               5                  10                  15      
Glu Gln Lys Ala Arg Glu Thr Leu Lys Asn Ser Ala Leu Ser Ala Gln
            20                  25                  30          
Leu Arg Glu Ala Ala Thr Gln Ala Gln Gln Thr Leu Gly Ser Thr Ile
        35                  40                  45              
Asp Lys Ala Thr Gly Ile Leu Leu Tyr Gly Leu Ala Ser Arg Leu Arg
    50                  55                  60                  
Asp Thr Arg Arg Leu Ser Phe Leu Val Ser Tyr Ile Ala Ser Lys Lys
65                  70                  75                  80  
Ile His Thr Glu Pro Gln Leu Ser Ala Ala Leu Glu Tyr Val Arg Ser
                85                  90                  95      
His Pro Leu Asp Pro Ile Asp Thr Val Asp Phe Glu Arg Glu Cys Gly
            100                 105                 110         
Val Gly Val Ile Val Thr Pro Glu Gln Ile Glu Glu Ala Val Glu Ala
        115                 120                 125             
Ala Ile Asn Arg His Arg Pro Gln Leu Leu Val Glu Arg Tyr His Phe
    130                 135                 140                 
Asn Met Gly Leu Leu Met Gly Glu Ala Arg Ala Val Leu Lys Trp Ala
145                 150                 155                 160 
Asp Gly Lys Met Ile Lys Asn Glu Val Asp Met Gln Val Leu His Leu
                165                 170                 175     
Leu Gly Pro Lys Leu Glu Ala Asp Leu Glu Lys Lys Phe Lys Val Ala
            180                 185                 190         
Lys Ala Arg Leu Glu Glu Thr Asp Arg Arg Thr Ala Lys Asp Val Val
        195                 200                 205             
Glu Asn Gly Glu Thr Ala Asp Gln Thr Leu Ser Leu Met Glu Gln Leu
    210                 215                 220                 
Arg Gly Glu Ala Leu Lys Phe His Lys Pro Gly Glu Asn Tyr Lys Thr
225                 230                 235                 240 
Pro Gly Tyr Val Val Thr Pro His Thr Met Asn Leu Leu Lys Gln His
                245                 250                 255     
Leu Glu Ile Thr Gly Gly Gln Val Arg Thr Arg Phe Pro Pro Glu Pro
            260                 265                 270         
Asn Gly Ile Leu His Ile Gly His Ala Lys Ala Ile Asn Phe Asn Phe
        275                 280                 285             
Gly Tyr Ala Lys Ala Asn Asn Gly Ile Cys Phe Leu Arg Phe Asp Asp
    290                 295                 300                 
Thr Asn Pro Glu Lys Glu Glu Ala Lys Phe Phe Thr Ala Ile Cys Asp
305                 310                 315                 320 
Met Val Ala Trp Leu Gly Tyr Thr Pro Tyr Lys Val Thr Tyr Ala Ser
                325                 330                 335     
Asp Tyr Phe Asp Gln Leu Tyr Ala Trp Ala Val Glu Leu Ile Arg Arg
            340                 345                 350         
Gly Leu Ala Tyr Val Cys His Gln Arg Gly Glu Glu Leu Lys Gly His
        355                 360                 365             
Asn Thr Leu Pro Ser Pro Trp Arg Asp Arg Pro Met Glu Glu Ser Leu
    370                 375                 380                 
Leu Leu Phe Glu Ala Met Arg Lys Gly Lys Phe Ser Glu Gly Glu Ala
385                 390                 395                 400 
Thr Leu Arg Met Lys Leu Val Met Glu Asp Gly Lys Met Asp Pro Val
                405                 410                 415     
Ala Tyr Arg Val Lys Tyr Thr Pro His His Arg Thr Gly Asp Lys Trp
            420                 425                 430         
Cys Ile Tyr Pro Thr Tyr Asp Tyr Thr His Cys Leu Cys Asp Ser Ile
        435                 440                 445             
Glu His Ile Thr His Ser Leu Cys Thr Lys Glu Phe Gln Ala Arg Arg
    450                 455                 460                 
Ser Ser Tyr Phe Trp Leu Cys Asn Ala Leu Asp Val Tyr Cys Pro Val
465                 470                 475                 480 
Gln Trp Glu Tyr Gly Arg Leu Asn Leu His Tyr Ala Val Val Ser Lys
                485                 490                 495     
Arg Lys Ile Leu Gln Leu Val Ala Thr Gly Ala Val Arg Asp Trp Asp
            500                 505                 510         
Asp Pro Arg Leu Phe Thr Leu Thr Ala Leu Arg Arg Arg Gly Phe Pro
        515                 520                 525             
Pro Glu Ala Ile Asn Asn Phe Cys Ala Arg Val Gly Val Thr Val Ala
    530                 535                 540                 
Gln Thr Thr Met Glu Pro His Leu Leu Glu Ala Cys Val Arg Asp Val
545                 550                 555                 560 
Leu Asn Asp Thr Ala Pro Arg Ala Met Ala Val Leu Glu Ser Leu Arg
                565                 570                 575     
Val Ile Ile Thr Asn Phe Pro Ala Ala Lys Ser Leu Asp Ile Gln Val
            580                 585                 590         
Pro Asn Phe Pro Ala Asp Glu Thr Lys Gly Phe His Gln Val Pro Phe
        595                 600                 605             
Ala Pro Ile Val Phe Ile Glu Arg Thr Asp Phe Lys Glu Glu Pro Glu
    610                 615                 620                 
Pro Gly Phe Lys Arg Leu Ala Trp Gly Gln Pro Val Gly Leu Arg His
625                 630                 635                 640 
Thr Gly Tyr Val Ile Glu Leu Gln His Val Val Lys Gly Pro Ser Gly
                645                 650                 655     
Cys Val Glu Ser Leu Glu Val Thr Cys Arg Arg Ala Asp Ala Gly Glu
            660                 665                 670         
Lys Pro Lys Ala Phe Ile His Trp Val Ser Gln Pro Leu Met Cys Glu
        675                 680                 685             
Val Arg Leu Tyr Glu Arg Leu Phe Gln His Lys Asn Pro Glu Asp Pro
    690                 695                 700                 
Thr Glu Val Pro Gly Gly Phe Leu Ser Asp Leu Asn Leu Ala Ser Leu
705                 710                 715                 720 
His Val Val Asp Ala Ala Leu Val Asp Cys Ser Val Ala Leu Ala Lys
                725                 730                 735     
Pro Phe Asp Lys Phe Gln Phe Glu Arg Leu Gly Tyr Phe Ser Val Asp
            740                 745                 750         
Pro Asp Ser His Gln Gly Lys Leu Val Phe Asn Arg Thr Val Thr Leu
        755                 760                 765             
Lys Glu Asp Pro Gly Lys Val
    770                 775 


<210> 26
<211> 15
<212> PRT
<213> Homo sapiens

<400> 26
Asp Val Val Glu Asn Gly Glu Thr Ala Asp Gln Thr Leu Ser Leu
 1               5                  10                  15  


<210> 27
<211> 10
<212> PRT
<213> Homo sapiens

<400> 27
Thr Pro Gly Tyr Val Val Thr Pro His Thr
 1               5                  10  


<210> 28
<211> 509
<212> PRT
<213> Homo sapiens

<400> 28
Met Ala Glu Arg Ala Ala Leu Glu Glu Leu Val Lys Leu Gln Gly Glu
 1               5                  10                  15      
Arg Val Arg Gly Leu Lys Gln Gln Lys Ala Ser Ala Glu Leu Ile Glu
            20                  25                  30          
Glu Glu Val Ala Lys Leu Leu Lys Leu Lys Ala Gln Leu Gly Pro Asp
        35                  40                  45              
Glu Ser Lys Gln Lys Phe Val Leu Lys Thr Pro Lys Gly Thr Arg Asp
    50                  55                  60                  
Tyr Ser Pro Arg Gln Met Ala Val Arg Glu Lys Val Phe Asp Val Ile
65                  70                  75                  80  
Ile Arg Cys Phe Lys Arg His Gly Ala Glu Val Ile Asp Thr Pro Val
                85                  90                  95      
Phe Glu Leu Lys Glu Thr Leu Met Gly Lys Tyr Gly Glu Asp Ser Lys
            100                 105                 110         
Leu Ile Tyr Asp Leu Lys Asp Gln Gly Gly Glu Leu Leu Ser Leu Arg
        115                 120                 125             
Tyr Asp Leu Thr Val Pro Phe Ala Arg Tyr Leu Ala Met Asn Lys Leu
    130                 135                 140                 
Thr Asn Ile Lys Arg Tyr His Ile Ala Lys Val Tyr Arg Arg Asp Asn
145                 150                 155                 160 
Pro Ala Met Thr Arg Gly Arg Tyr Arg Glu Phe Tyr Gln Cys Asp Phe
                165                 170                 175     
Asp Ile Ala Gly Asn Phe Asp Pro Met Ile Pro Asp Ala Glu Cys Leu
            180                 185                 190         
Lys Ile Met Cys Glu Ile Leu Ser Ser Leu Gln Ile Gly Asp Phe Leu
        195                 200                 205             
Val Lys Val Asn Asp Arg Arg Ile Leu Asp Gly Met Phe Ala Ile Cys
    210                 215                 220                 
Gly Val Ser Asp Ser Lys Phe Arg Thr Ile Cys Ser Ser Val Asp Lys
225                 230                 235                 240 
Leu Asp Lys Val Ser Trp Glu Glu Val Lys Asn Glu Met Val Gly Glu
                245                 250                 255     
Lys Gly Leu Ala Pro Glu Val Ala Asp Arg Ile Gly Asp Tyr Val Gln
            260                 265                 270         
Gln His Gly Gly Val Ser Leu Val Glu Gln Leu Leu Gln Asp Pro Lys
        275                 280                 285             
Leu Ser Gln Asn Lys Gln Ala Leu Glu Gly Leu Gly Asp Leu Lys Leu
    290                 295                 300                 
Leu Phe Glu Tyr Leu Thr Leu Phe Gly Ile Asp Asp Lys Ile Ser Phe
305                 310                 315                 320 
Asp Leu Ser Leu Ala Arg Gly Leu Asp Tyr Tyr Thr Gly Val Ile Tyr
                325                 330                 335     
Glu Ala Val Leu Leu Gln Thr Pro Ala Gln Ala Gly Glu Glu Pro Leu
            340                 345                 350         
Gly Val Gly Ser Val Ala Ala Gly Gly Arg Tyr Asp Gly Leu Val Gly
        355                 360                 365             
Met Phe Asp Pro Lys Gly Arg Lys Val Pro Cys Val Gly Leu Ser Ile
    370                 375                 380                 
Gly Val Glu Arg Ile Phe Ser Ile Val Glu Gln Arg Leu Glu Ala Leu
385                 390                 395                 400 
Glu Glu Lys Ile Arg Thr Thr Glu Thr Gln Val Leu Val Ala Ser Ala
                405                 410                 415     
Gln Lys Lys Leu Leu Glu Glu Arg Leu Lys Leu Val Ser Glu Leu Trp
            420                 425                 430         
Asp Ala Gly Ile Lys Ala Glu Leu Leu Tyr Lys Lys Asn Pro Lys Leu
        435                 440                 445             
Leu Asn Gln Leu Gln Tyr Cys Glu Glu Ala Gly Ile Pro Leu Val Ala
    450                 455                 460                 
Ile Ile Gly Glu Gln Glu Leu Lys Asp Gly Val Ile Lys Leu Arg Ser
465                 470                 475                 480 
Val Thr Ser Arg Glu Glu Val Asp Val Arg Arg Glu Asp Leu Val Glu
                485                 490                 495     
Glu Ile Lys Arg Arg Thr Gly Gln Pro Leu Cys Ile Cys
            500                 505                 


<210> 29
<211> 183
<212> DNA
<213> Homo sapiens

<400> 29
atggcagagc gtgcggcgct ggaggagctg gtgaaacttc agggagagcg cgtgcgaggc 60
ctcaagcagc agaaggccag cgccgagctg atcgaggagg aggtggcgaa actcctgaaa 120
ctgaaggcac agctgggtcc tgatgaaagc aaacagaaat ttgtgctcaa aacccccaag 180
tag                                                               183

<210> 30
<211> 60
<212> PRT
<213> Homo sapiens

<400> 30
Met Ala Glu Arg Ala Ala Leu Glu Glu Leu Val Lys Leu Gln Gly Glu
 1               5                  10                  15      
Arg Val Arg Gly Leu Lys Gln Gln Lys Ala Ser Ala Glu Leu Ile Glu
            20                  25                  30          
Glu Glu Val Ala Lys Leu Leu Lys Leu Lys Ala Gln Leu Gly Pro Asp
        35                  40                  45              
Glu Ser Lys Gln Lys Phe Val Leu Lys Thr Pro Lys
    50                  55                  60  


<210> 31
<211> 516
<212> DNA
<213> Homo sapiens

<400> 31
atggcagagc gtgcggcgct ggaggagctg gtgaaacttc agggagagcg cgtgcgaggc 60
ctcaagcagc agaaggccag cgccgagctg atcgaggagg aggtggcgaa actcctgaaa 120
ctgaaggcac agctgggtcc tgatgaaagc aaacagaaat ttgtgctcaa aacccccaag 180
gctttggagg agaagatacg gaccacggag acacaggtgc ttgtggcatc tgcacagaag 240
aagctgctag aggaaagact aaagcttgtc tcagaactgt gggatgctgg gatcaaggct 300
gagctgctgt acaagaagaa cccaaagcta ctgaaccagt tacagtactg tgaggaggca 360
ggcatcccac tggtggctat catcggcgag caggaactca aggatggggt catcaagctc 420
cgttcagtga cgagcaggga agaggtggat gtccgaagag aagaccttgt ggaggaaatc 480
aaaaggagaa caggccagcc cctctgcatc tgctga                           516

<210> 32
<211> 171
<212> PRT
<213> Homo sapiens

<400> 32
Met Ala Glu Arg Ala Ala Leu Glu Glu Leu Val Lys Leu Gln Gly Glu
 1               5                  10                  15      
Arg Val Arg Gly Leu Lys Gln Gln Lys Ala Ser Ala Glu Leu Ile Glu
            20                  25                  30          
Glu Glu Val Ala Lys Leu Leu Lys Leu Lys Ala Gln Leu Gly Pro Asp
        35                  40                  45              
Glu Ser Lys Gln Lys Phe Val Leu Lys Thr Pro Lys Ala Leu Glu Glu
    50                  55                  60                  
Lys Ile Arg Thr Thr Glu Thr Gln Val Leu Val Ala Ser Ala Gln Lys
65                  70                  75                  80  
Lys Leu Leu Glu Glu Arg Leu Lys Leu Val Ser Glu Leu Trp Asp Ala
                85                  90                  95      
Gly Ile Lys Ala Glu Leu Leu Tyr Lys Lys Asn Pro Lys Leu Leu Asn
            100                 105                 110         
Gln Leu Gln Tyr Cys Glu Glu Ala Gly Ile Pro Leu Val Ala Ile Ile
        115                 120                 125             
Gly Glu Gln Glu Leu Lys Asp Gly Val Ile Lys Leu Arg Ser Val Thr
    130                 135                 140                 
Ser Arg Glu Glu Val Asp Val Arg Arg Glu Asp Leu Val Glu Glu Ile
145                 150                 155                 160 
Lys Arg Arg Thr Gly Gln Pro Leu Cys Ile Cys
                165                 170     


<210> 33
<211> 471
<212> PRT
<213> Homo sapiens

<400> 33
Met Pro Asn Ser Glu Pro Ala Ser Leu Leu Glu Leu Phe Asn Ser Ile
 1               5                  10                  15      
Ala Thr Gln Gly Glu Leu Val Arg Ser Leu Lys Ala Gly Asn Ala Ser
            20                  25                  30          
Lys Asp Glu Ile Asp Ser Ala Val Lys Met Leu Val Ser Leu Lys Met
        35                  40                  45              
Ser Tyr Lys Ala Ala Ala Gly Glu Asp Tyr Lys Ala Asp Cys Pro Pro
    50                  55                  60                  
Gly Asn Pro Ala Pro Thr Ser Asn His Gly Pro Asp Ala Thr Glu Ala
65                  70                  75                  80  
Glu Glu Asp Phe Val Asp Pro Trp Thr Val Gln Thr Ser Ser Ala Lys
                85                  90                  95      
Gly Ile Asp Tyr Asp Lys Leu Ile Val Arg Phe Gly Ser Ser Lys Ile
            100                 105                 110         
Asp Lys Glu Leu Ile Asn Arg Ile Glu Arg Ala Thr Gly Gln Arg Pro
        115                 120                 125             
His His Phe Leu Arg Arg Gly Ile Phe Phe Ser His Arg Asp Met Asn
    130                 135                 140                 
Gln Val Leu Asp Ala Tyr Glu Asn Lys Lys Pro Phe Tyr Leu Tyr Thr
145                 150                 155                 160 
Gly Arg Gly Pro Ser Ser Glu Ala Met His Val Gly His Leu Ile Pro
                165                 170                 175     
Phe Ile Phe Thr Lys Trp Leu Gln Asp Val Phe Asn Val Pro Leu Val
            180                 185                 190         
Ile Gln Met Thr Asp Asp Glu Lys Tyr Leu Trp Lys Asp Leu Thr Leu
        195                 200                 205             
Asp Gln Ala Tyr Ser Tyr Ala Val Glu Asn Ala Lys Asp Ile Ile Ala
    210                 215                 220                 
Cys Gly Phe Asp Ile Asn Lys Thr Phe Ile Phe Ser Asp Leu Asp Tyr
225                 230                 235                 240 
Met Gly Met Ser Ser Gly Phe Tyr Lys Asn Val Val Lys Ile Gln Lys
                245                 250                 255     
His Val Thr Phe Asn Gln Val Lys Gly Ile Phe Gly Phe Thr Asp Ser
            260                 265                 270         
Asp Cys Ile Gly Lys Ile Ser Phe Pro Ala Ile Gln Ala Ala Pro Ser
        275                 280                 285             
Phe Ser Asn Ser Phe Pro Gln Ile Phe Arg Asp Arg Thr Asp Ile Gln
    290                 295                 300                 
Cys Leu Ile Pro Cys Ala Ile Asp Gln Asp Pro Tyr Phe Arg Met Thr
305                 310                 315                 320 
Arg Asp Val Ala Pro Arg Ile Gly Tyr Pro Lys Pro Ala Leu Leu His
                325                 330                 335     
Ser Thr Phe Phe Pro Ala Leu Gln Gly Ala Gln Thr Lys Met Ser Ala
            340                 345                 350         
Ser Asp Pro Asn Ser Ser Ile Phe Leu Thr Asp Thr Ala Lys Gln Ile
        355                 360                 365             
Lys Thr Lys Val Asn Lys His Ala Phe Ser Gly Gly Arg Asp Thr Ile
    370                 375                 380                 
Glu Glu His Arg Gln Phe Gly Gly Asn Cys Asp Val Asp Val Ser Phe
385                 390                 395                 400 
Met Tyr Leu Thr Phe Phe Leu Glu Asp Asp Asp Lys Leu Glu Gln Ile
                405                 410                 415     
Arg Lys Asp Tyr Thr Ser Gly Ala Met Leu Thr Gly Glu Leu Lys Lys
            420                 425                 430         
Ala Leu Ile Glu Val Leu Gln Pro Leu Ile Ala Glu His Gln Ala Arg
        435                 440                 445             
Arg Lys Glu Val Thr Asp Glu Ile Val Lys Glu Phe Met Thr Pro Arg
    450                 455                 460                 
Lys Leu Ser Phe Asp Phe Gln
465                 470     


<210> 34
<211> 379
<212> PRT
<213> Homo sapiens

<400> 34
Met Ser Ala Lys Gly Ile Asp Tyr Asp Lys Leu Ile Val Arg Phe Gly
 1               5                  10                  15      
Ser Ser Lys Ile Asp Lys Glu Leu Ile Asn Arg Ile Glu Arg Ala Thr
            20                  25                  30          
Gly Gln Arg Pro His His Phe Leu Arg Arg Gly Ile Phe Phe Ser His
        35                  40                  45              
Arg Asp Met Asn Gln Val Leu Asp Ala Tyr Glu Asn Lys Lys Pro Phe
    50                  55                  60                  
Tyr Leu Tyr Thr Gly Arg Gly Pro Ser Ser Glu Ala Met His Val Gly
65                  70                  75                  80  
His Leu Ile Pro Phe Ile Phe Thr Lys Trp Leu Gln Asp Val Phe Asn
                85                  90                  95      
Val Pro Leu Val Ile Gln Met Thr Asp Asp Glu Lys Tyr Leu Trp Lys
            100                 105                 110         
Asp Leu Thr Leu Asp Gln Ala Tyr Ser Tyr Ala Val Glu Asn Ala Lys
        115                 120                 125             
Asp Ile Ile Ala Cys Gly Phe Asp Ile Asn Lys Thr Phe Ile Phe Ser
    130                 135                 140                 
Asp Leu Asp Tyr Met Gly Met Ser Ser Gly Phe Tyr Lys Asn Val Val
145                 150                 155                 160 
Lys Ile Gln Lys His Val Thr Phe Asn Gln Val Lys Gly Ile Phe Gly
                165                 170                 175     
Phe Thr Asp Ser Asp Cys Ile Gly Lys Ile Ser Phe Pro Ala Ile Gln
            180                 185                 190         
Ala Ala Pro Ser Phe Ser Asn Ser Phe Pro Gln Ile Phe Arg Asp Arg
        195                 200                 205             
Thr Asp Ile Gln Cys Leu Ile Pro Cys Ala Ile Asp Gln Asp Pro Tyr
    210                 215                 220                 
Phe Arg Met Thr Arg Asp Val Ala Pro Arg Ile Gly Tyr Pro Lys Pro
225                 230                 235                 240 
Ala Leu Leu His Ser Thr Phe Phe Pro Ala Leu Gln Gly Ala Gln Thr
                245                 250                 255     
Lys Met Ser Ala Ser Asp Pro Asn Ser Ser Ile Phe Leu Thr Asp Thr
            260                 265                 270         
Ala Lys Gln Ile Lys Thr Lys Val Asn Lys His Ala Phe Ser Gly Gly
        275                 280                 285             
Arg Asp Thr Ile Glu Glu His Arg Gln Phe Gly Gly Asn Cys Asp Val
    290                 295                 300                 
Asp Val Ser Phe Met Tyr Leu Thr Phe Phe Leu Glu Asp Asp Asp Lys
305                 310                 315                 320 
Leu Glu Gln Ile Arg Lys Asp Tyr Thr Ser Gly Ala Met Leu Thr Gly
                325                 330                 335     
Glu Leu Lys Lys Ala Leu Ile Glu Val Leu Gln Pro Leu Ile Ala Glu
            340                 345                 350         
His Gln Ala Arg Arg Lys Glu Val Thr Asp Glu Ile Val Lys Glu Phe
        355                 360                 365             
Met Thr Pro Arg Lys Leu Ser Phe Asp Phe Gln
    370                 375                 


<210> 35
<211> 424
<212> PRT
<213> Homo sapiens

<400> 35
Met Ser Tyr Lys Ala Ala Ala Gly Glu Asp Tyr Lys Ala Asp Cys Pro
 1               5                  10                  15      
Pro Gly Asn Pro Ala Pro Thr Ser Asn His Gly Pro Asp Ala Thr Glu
            20                  25                  30          
Ala Glu Glu Asp Phe Val Asp Pro Trp Thr Val Gln Thr Ser Ser Ala
        35                  40                  45              
Lys Gly Ile Asp Tyr Asp Lys Leu Ile Val Arg Phe Gly Ser Ser Lys
    50                  55                  60                  
Ile Asp Lys Glu Leu Ile Asn Arg Ile Glu Arg Ala Thr Gly Gln Arg
65                  70                  75                  80  
Pro His His Phe Leu Arg Arg Gly Ile Phe Phe Ser His Arg Asp Met
                85                  90                  95      
Asn Gln Val Leu Asp Ala Tyr Glu Asn Lys Lys Pro Phe Tyr Leu Tyr
            100                 105                 110         
Thr Gly Arg Gly Pro Ser Ser Glu Ala Met His Val Gly His Leu Ile
        115                 120                 125             
Pro Phe Ile Phe Thr Lys Trp Leu Gln Asp Val Phe Asn Val Pro Leu
    130                 135                 140                 
Val Ile Gln Met Thr Asp Asp Glu Lys Tyr Leu Trp Lys Asp Leu Thr
145                 150                 155                 160 
Leu Asp Gln Ala Tyr Ser Tyr Ala Val Glu Asn Ala Lys Asp Ile Ile
                165                 170                 175     
Ala Cys Gly Phe Asp Ile Asn Lys Thr Phe Ile Phe Ser Asp Leu Asp
            180                 185                 190         
Tyr Met Gly Met Ser Ser Gly Phe Tyr Lys Asn Val Val Lys Ile Gln
        195                 200                 205             
Lys His Val Thr Phe Asn Gln Val Lys Gly Ile Phe Gly Phe Thr Asp
    210                 215                 220                 
Ser Asp Cys Ile Gly Lys Ile Ser Phe Pro Ala Ile Gln Ala Ala Pro
225                 230                 235                 240 
Ser Phe Ser Asn Ser Phe Pro Gln Ile Phe Arg Asp Arg Thr Asp Ile
                245                 250                 255     
Gln Cys Leu Ile Pro Cys Ala Ile Asp Gln Asp Pro Tyr Phe Arg Met
            260                 265                 270         
Thr Arg Asp Val Ala Pro Arg Ile Gly Tyr Pro Lys Pro Ala Leu Leu
        275                 280                 285             
His Ser Thr Phe Phe Pro Ala Leu Gln Gly Ala Gln Thr Lys Met Ser
    290                 295                 300                 
Ala Ser Asp Pro Asn Ser Ser Ile Phe Leu Thr Asp Thr Ala Lys Gln
305                 310                 315                 320 
Ile Lys Thr Lys Val Asn Lys His Ala Phe Ser Gly Gly Arg Asp Thr
                325                 330                 335     
Ile Glu Glu His Arg Gln Phe Gly Gly Asn Cys Asp Val Asp Val Ser
            340                 345                 350         
Phe Met Tyr Leu Thr Phe Phe Leu Glu Asp Asp Asp Lys Leu Glu Gln
        355                 360                 365             
Ile Arg Lys Asp Tyr Thr Ser Gly Ala Met Leu Thr Gly Glu Leu Lys
    370                 375                 380                 
Lys Ala Leu Ile Glu Val Leu Gln Pro Leu Ile Ala Glu His Gln Ala
385                 390                 395                 400 
Arg Arg Lys Glu Val Thr Asp Glu Ile Val Lys Glu Phe Met Thr Pro
                405                 410                 415     
Arg Lys Leu Ser Phe Asp Phe Gln
            420                 


<210> 36
<211> 13
<212> PRT
<213> Mus musculus

<400> 36
Glu Thr Leu Lys Asn Glu Ala Leu Ser Thr Gln Leu Arg
 1               5                  10              


<210> 37
<211> 28
<212> PRT
<213> Mus musculus

<400> 37
Glu Ala Ala Thr Gln Ala His Gln Ile Leu Gly Ser Thr Ile Asp Lys
 1               5                  10                  15      
Ala Thr Gly Val Leu Leu Tyr Asp Leu Val Ser Arg
            20                  25              


<210> 38
<211> 41
<212> PRT
<213> Mus musculus

<400> 38
Glu Thr Leu Lys Asn Glu Ala Leu Ser Thr Gln Leu Arg Glu Ala Ala
 1               5                  10                  15      
Thr Gln Ala His Gln Ile Leu Gly Ser Thr Ile Asp Lys Ala Thr Gly
            20                  25                  30          
Val Leu Leu Tyr Asp Leu Val Ser Arg
        35                  40      


<210> 39
<211> 27
<212> PRT
<213> Mus musculus

<400> 39
Asp Phe Glu Gln Glu Cys Gly Val Gly Val Val Val Thr Pro Glu Gln
 1               5                  10                  15      
Ile Glu Glu Ala Val Glu Ser Thr Ile Asn Lys
            20                  25          


<210> 40
<211> 11
<212> PRT
<213> Mus musculus

<400> 40
Phe Asn Met Gly Leu Leu Met Gly Glu Ala Arg
 1               5                  10      


<210> 41
<211> 17
<212> PRT
<213> Mus musculus

<400> 41
Met Ile Lys Asn Glu Val Asp Met Gln Val Leu His Leu Leu Gly Pro
 1               5                  10                  15      
Lys
    


<210> 42
<211> 14
<212> PRT
<213> Mus musculus

<400> 42
Asn Glu Val Asp Met Gln Val Leu His Leu Leu Gly Pro Lys
 1               5                  10                  


<210> 43
<211> 15
<212> PRT
<213> Mus musculus

<400> 43
Thr Pro Gly Tyr Val Ile Thr Pro Tyr Thr Met Asp Leu Leu Lys
 1               5                  10                  15  


<210> 44
<211> 12
<212> PRT
<213> Mus musculus

<400> 44
Phe Asp Asp Thr Asn Pro Glu Lys Glu Glu Ala Lys
 1               5                  10          


<210> 45
<211> 15
<212> PRT
<213> Mus musculus

<400> 45
Val Glu Glu Leu Lys Gly His Asn Pro Leu Pro Ser Pro Trp Arg
 1               5                  10                  15  


<210> 46
<211> 15
<212> PRT
<213> Mus musculus

<400> 46
Asp Arg Pro Lys Glu Glu Ser Leu Leu Leu Phe Glu Ala Met Arg
 1               5                  10                  15  


<210> 47
<211> 30
<212> PRT
<213> Mus musculus

<400> 47
Val Glu Glu Leu Lys Gly His Asn Pro Leu Pro Ser Pro Trp Arg Asp
 1               5                  10                  15      
Arg Pro Lys Glu Glu Ser Leu Leu Leu Phe Glu Ala Met Arg
            20                  25                  30  


<210> 48
<211> 14
<212> PRT
<213> Mus musculus

<400> 48
Leu Val Met Glu Asp Gly Lys Met Asp Pro Val Ala Tyr Arg
 1               5                  10                  


<210> 49
<211> 11
<212> PRT
<213> Mus musculus

<400> 49
Val Tyr Cys Pro Val Gln Trp Glu Tyr Gly Arg
 1               5                  10      


<210> 50
<211> 11
<212> PRT
<213> Mus musculus

<400> 50
Ile Leu Gln Leu Val Ala Ala Gly Ala Val Arg
 1               5                  10      


<210> 51
<211> 28
<212> PRT
<213> Mus musculus

<400> 51
Asp Val Leu Asn Asp Ala Ala Pro Arg Ala Met Ala Val Leu Glu Pro
 1               5                  10                  15      
Leu Gln Val Val Ile Thr Asn Phe Pro Ala Pro Lys
            20                  25              


<210> 52
<211> 38
<212> PRT
<213> Mus musculus

<400> 52
Gly Phe His Gln Val Pro Phe Ala Ser Thr Val Phe Ile Glu Arg Ser
 1               5                  10                  15      
Asp Phe Lys Glu Glu Ser Glu Pro Gly Tyr Lys Arg Leu Ala Ser Gly
            20                  25                  30          
Gln Pro Val Gly Leu Arg
        35              


<210> 53
<211> 15
<212> PRT
<213> Mus musculus

<400> 53
Ala Phe Ile His Trp Val Ser Gln Pro Leu Val Cys Glu Ile Arg
 1               5                  10                  15  


<210> 54
<211> 19
<212> PRT
<213> Mus musculus

<400> 54
Leu Gly Tyr Phe Ser Val Asp Pro Asp Ser His Gln Gly Gln Ile Val
 1               5                  10                  15      
Phe Asn Arg
            


<210> 55
<211> 15
<212> PRT
<213> Mus musculus

<400> 55
Thr Pro Gly Tyr Val Ile Thr Pro Tyr Thr Met Asp Leu Leu Lys
 1               5                  10                  15  


<210> 56
<211> 10
<212> PRT
<213> Mus musculus

<400> 56
Ala Ile Asn Phe Asn Phe Gly Tyr Ala Lys
 1               5                  10  


<210> 57
<211> 12
<212> PRT
<213> Mus musculus

<400> 57
Phe Asp Asp Thr Asn Pro Glu Lys Glu Glu Ala Lys
 1               5                  10          


<210> 58
<211> 18
<212> PRT
<213> Mus musculus

<400> 58
Phe Phe Thr Ala Ile Tyr Asp Met Val Thr Trp Leu Gly Tyr Thr Pro
 1               5                  10                  15      
Tyr Lys
        


<210> 59
<211> 30
<212> PRT
<213> Mus musculus

<400> 59
Phe Asp Asp Thr Asn Pro Glu Lys Glu Glu Ala Lys Phe Phe Thr Ala
 1               5                  10                  15      
Ile Tyr Asp Met Val Thr Trp Leu Gly Tyr Thr Pro Tyr Lys
            20                  25                  30  


<210> 60
<211> 15
<212> PRT
<213> Mus musculus

<400> 60
Asp Arg Pro Lys Glu Glu Ser Leu Leu Leu Phe Glu Ala Met Arg
 1               5                  10                  15  


<210> 61
<211> 11
<212> PRT
<213> Mus musculus

<400> 61
Val Tyr Cys Pro Val Gln Trp Glu Tyr Gly Arg
 1               5                  10      


<210> 62
<211> 10
<212> PRT
<213> Mus musculus

<400> 62
Leu Asn Leu His Tyr Ala Val Val Ser Lys
 1               5                  10  


<210> 63
<211> 21
<212> PRT
<213> Mus musculus

<400> 63
Val Tyr Cys Pro Val Gln Trp Glu Tyr Gly Arg Leu Asn Leu His Tyr
 1               5                  10                  15      
Ala Val Val Ser Lys
            20      


<210> 64
<211> 11
<212> PRT
<213> Mus musculus

<400> 64
Ile Leu Gln Leu Val Ala Ala Gly Ala Val Arg
 1               5                  10      


<210> 65
<211> 19
<212> PRT
<213> Mus musculus

<400> 65
Ala Met Ala Val Leu Glu Pro Leu Gln Val Val Ile Thr Asn Phe Pro
 1               5                  10                  15      
Ala Pro Lys
            


<210> 66
<211> 15
<212> PRT
<213> Mus musculus

<400> 66
Pro Leu Asp Ile Arg Val Pro Asn Phe Pro Ala Asp Glu Thr Lys
 1               5                  10                  15  


<210> 67
<211> 34
<212> PRT
<213> Mus musculus

<400> 67
Ala Met Ala Val Leu Glu Pro Leu Gln Val Val Ile Thr Asn Phe Pro
 1               5                  10                  15      
Ala Pro Lys Pro Leu Asp Ile Arg Val Pro Asn Phe Pro Ala Asp Glu
            20                  25                  30          
Thr Lys
        


<210> 68
<211> 36
<212> PRT
<213> Mus musculus

<400> 68
Ser Asp Phe Lys Glu Glu Ser Glu Pro Gly Tyr Lys Arg Leu Ala Ser
 1               5                  10                  15      
Gly Gln Pro Val Gly Leu Arg His Thr Gly Tyr Val Ile Glu Leu Gln
            20                  25                  30          
Asn Ile Val Arg
        35      


<210> 69
<211> 15
<212> PRT
<213> Mus musculus

<400> 69
Ala Phe Ile His Trp Val Ser Gln Pro Leu Val Cys Glu Ile Arg
 1               5                  10                  15  


<210> 70
<211> 19
<212> PRT
<213> Mus musculus

<400> 70
Leu Gly Tyr Phe Ser Val Asp Pro Asp Ser His Gln Gly Gln Ile Val
 1               5                  10                  15      
Phe Asn Arg
            


<210> 71
<211> 13
<212> PRT
<213> Mus musculus

<400> 71
Lys Ala Thr Gly Val Leu Leu Tyr Asp Leu Val Ser Arg
 1               5                  10              


<210> 72
<211> 10
<212> PRT
<213> Mus musculus

<400> 72
Ser Phe Leu Val Ser Tyr Ile Ala Asn Lys
 1               5                  10  


<210> 73
<211> 27
<212> PRT
<213> Mus musculus

<400> 73
Asp Phe Glu Gln Glu Cys Gly Val Gly Val Val Val Thr Pro Glu Gln
 1               5                  10                  15      
Ile Glu Glu Ala Val Glu Ser Thr Ile Asn Lys
            20                  25          


<210> 74
<211> 17
<212> PRT
<213> Mus musculus

<400> 74
Met Ile Lys Asn Glu Val Asp Met Gln Val Leu His Leu Leu Gly Pro
 1               5                  10                  15      
Lys
    


<210> 75
<211> 28
<212> PRT
<213> Mus musculus

<400> 75
Glu Ala Ala Thr Gln Ala His Gln Ile Leu Gly Ser Thr Ile Asp Lys
 1               5                  10                  15      
Ala Thr Gly Val Leu Leu Tyr Asp Leu Val Ser Arg
            20                  25              


<210> 76
<211> 13
<212> PRT
<213> Homo sapiens

<400> 76
Glu Thr Leu Lys Asn Ser Ala Leu Ser Ala Gln Leu Arg
 1               5                  10              


<210> 77
<211> 28
<212> PRT
<213> Homo sapiens

<400> 77
Glu Ala Ala Thr Gln Ala Gln Gln Thr Leu Gly Ser Thr Ile Asp Lys
 1               5                  10                  15      
Ala Thr Gly Ile Leu Leu Tyr Gly Leu Ala Ser Arg
            20                  25              


<210> 78
<211> 41
<212> PRT
<213> Homo sapiens

<400> 78
Glu Thr Leu Lys Asn Ser Ala Leu Ser Ala Gln Leu Arg Glu Ala Ala
 1               5                  10                  15      
Thr Gln Ala Gln Gln Thr Leu Gly Ser Thr Ile Asp Lys Ala Thr Gly
            20                  25                  30          
Ile Leu Leu Tyr Gly Leu Ala Ser Arg
        35                  40      


<210> 79
<211> 27
<212> PRT
<213> Homo sapiens

<400> 79
Asp Phe Glu Arg Glu Cys Gly Val Gly Val Ile Val Thr Pro Glu Gln
 1               5                  10                  15      
Ile Glu Glu Ala Val Glu Ala Ala Ile Asn Arg
            20                  25          


<210> 80
<211> 15
<212> PRT
<213> Homo sapiens

<400> 80
Thr Pro Gly Tyr Val Val Thr Pro His Thr Met Asn Leu Leu Lys
 1               5                  10                  15  


<210> 81
<211> 15
<212> PRT
<213> Homo sapiens

<400> 81
Gly Glu Glu Leu Lys Gly His Asn Thr Leu Pro Ser Pro Trp Arg
 1               5                  10                  15  


<210> 82
<211> 15
<212> PRT
<213> Homo sapiens

<400> 82
Asp Arg Pro Met Glu Glu Ser Leu Leu Leu Phe Glu Ala Met Arg
 1               5                  10                  15  


<210> 83
<211> 30
<212> PRT
<213> Homo sapiens

<400> 83
Gly Glu Glu Leu Lys Gly His Asn Thr Leu Pro Ser Pro Trp Arg Asp
 1               5                  10                  15      
Arg Pro Met Glu Glu Ser Leu Leu Leu Phe Glu Ala Met Arg
            20                  25                  30  


<210> 84
<211> 11
<212> PRT
<213> Homo sapiens

<400> 84
Ile Leu Gln Leu Val Ala Thr Gly Ala Val Arg
 1               5                  10      


<210> 85
<211> 28
<212> PRT
<213> Homo sapiens

<400> 85
Asp Val Leu Asn Asp Thr Ala Pro Arg Ala Met Ala Val Leu Glu Ser
 1               5                  10                  15      
Leu Arg Val Ile Ile Thr Asn Phe Pro Ala Ala Lys
            20                  25              


<210> 86
<211> 38
<212> PRT
<213> Homo sapiens

<400> 86
Gly Phe His Gln Val Pro Phe Ala Pro Ile Val Phe Ile Glu Arg Thr
 1               5                  10                  15      
Asp Phe Lys Glu Glu Pro Glu Pro Gly Phe Lys Arg Leu Ala Trp Gly
            20                  25                  30          
Gln Pro Val Gly Leu Arg
        35              


<210> 87
<211> 15
<212> PRT
<213> Homo sapiens

<400> 87
Ala Phe Ile His Trp Val Ser Gln Pro Leu Met Cys Glu Val Arg
 1               5                  10                  15  


<210> 88
<211> 19
<212> PRT
<213> Homo sapiens

<400> 88
Leu Gly Tyr Phe Ser Val Asp Pro Asp Ser His Gln Gly Lys Leu Val
 1               5                  10                  15      
Phe Asn Arg
            


<210> 89
<211> 15
<212> PRT
<213> Homo sapiens

<400> 89
Thr Pro Gly Tyr Val Val Thr Pro His Thr Met Asn Leu Leu Lys
 1               5                  10                  15  


<210> 90
<211> 18
<212> PRT
<213> Homo sapiens

<400> 90
Phe Phe Thr Ala Ile Cys Asp Met Val Ala Trp Leu Gly Tyr Thr Pro
 1               5                  10                  15      
Tyr Lys
        


<210> 91
<211> 30
<212> PRT
<213> Homo sapiens

<400> 91
Phe Asp Asp Thr Asn Pro Glu Lys Glu Glu Ala Lys Phe Phe Thr Ala
 1               5                  10                  15      
Ile Tyr Asp Met Val Thr Trp Leu Gly Tyr Thr Pro Tyr Lys
            20                  25                  30  


<210> 92
<211> 15
<212> PRT
<213> Homo sapiens

<400> 92
Asp Arg Pro Met Glu Glu Ser Leu Leu Leu Phe Glu Ala Met Arg
 1               5                  10                  15  


<210> 93
<211> 11
<212> PRT
<213> Homo sapiens

<400> 93
Ile Leu Gln Leu Val Ala Thr Gly Ala Val Arg
 1               5                  10      


<210> 94
<211> 19
<212> PRT
<213> Homo sapiens

<400> 94
Ala Met Ala Val Leu Glu Ser Leu Arg Val Ile Ile Thr Asn Phe Pro
 1               5                  10                  15      
Ala Ala Lys
            


<210> 95
<211> 15
<212> PRT
<213> Homo sapiens

<400> 95
Ser Leu Asp Ile Gln Val Pro Asn Phe Pro Ala Asp Glu Thr Lys
 1               5                  10                  15  


<210> 96
<211> 34
<212> PRT
<213> Homo sapiens

<400> 96
Ala Met Ala Val Leu Glu Ser Leu Arg Val Ile Ile Thr Asn Phe Pro
 1               5                  10                  15      
Ala Ala Lys Ser Leu Asp Ile Gln Val Pro Asn Phe Pro Ala Asp Glu
            20                  25                  30          
Thr Lys
        


<210> 97
<211> 36
<212> PRT
<213> Homo sapiens

<400> 97
Thr Asp Phe Lys Glu Glu Pro Glu Pro Gly Phe Lys Arg Leu Ala Trp
 1               5                  10                  15      
Gly Gln Pro Val Gly Leu Arg His Thr Gly Tyr Val Ile Glu Leu Gln
            20                  25                  30          
His Val Val Lys
        35      


<210> 98
<211> 15
<212> PRT
<213> Homo sapiens

<400> 98
Ala Phe Ile His Trp Val Ser Gln Pro Leu Met Cys Glu Val Arg
 1               5                  10                  15  


<210> 99
<211> 19
<212> PRT
<213> Homo sapiens

<400> 99
Leu Gly Tyr Phe Ser Val Asp Pro Asp Ser His Gln Gly Lys Leu Val
 1               5                  10                  15      
Phe Asn Arg
            


<210> 100
<211> 13
<212> PRT
<213> Homo sapiens

<400> 100
Lys Ala Thr Gly Ile Leu Leu Tyr Gly Leu Ala Ser Arg
 1               5                  10              


<210> 101
<211> 10
<212> PRT
<213> Homo sapiens

<400> 101
Ser Phe Leu Val Ser Tyr Ile Ala Ser Lys
 1               5                  10  


<210> 102
<211> 27
<212> PRT
<213> Homo sapiens

<400> 102
Asp Phe Glu Arg Glu Cys Gly Val Gly Val Ile Val Thr Pro Glu Gln
 1               5                  10                  15      
Ile Glu Glu Ala Val Glu Ala Ala Ile Asn Arg
            20                  25          


<210> 103
<211> 28
<212> PRT
<213> Homo sapiens

<400> 103
Glu Ala Ala Thr Gln Ala Gln Gln Thr Leu Gly Ser Thr Ile Asp Lys
 1               5                  10                  15      
Ala Thr Gly Ile Leu Leu Tyr Gly Leu Ala Ser Arg
            20                  25              


<210> 104
<211> 86
<212> PRT
<213> Homo sapiens

<400> 104
Met Pro Thr Val Ser Val Lys Arg Asp Leu Leu Phe Gln Ala Leu Gly
 1               5                  10                  15      
Arg Thr Tyr Thr Asp Glu Glu Phe Asp Glu Leu Cys Phe Glu Phe Gly
            20                  25                  30          
Leu Glu Leu Asp Glu Ile Lys Asp Leu Glu Leu Leu Cys Pro Arg Cys
        35                  40                  45              
Ser Leu Ser Thr Asp His Gln His Arg Cys Val Trp Pro Ile Lys Lys
    50                  55                  60                  
Ala Ala Ser Tyr Gln Glu Lys Thr Gly Ala Ile Gln Cys Thr Val Glu
65                  70                  75                  80  
Gly Glu Ser Gly Thr Asn
                85      


<210> 105
<211> 501
<212> PRT
<213> Homo sapiens

<400> 105
Met Pro Ser Ala Ser Ala Ser Arg Lys Ser Gln Glu Lys Pro Arg Glu
 1               5                  10                  15      
Ile Met Asp Ala Ala Glu Asp Tyr Ala Lys Glu Arg Tyr Gly Ile Ser
            20                  25                  30          
Ser Met Ile Gln Ser Gln Glu Lys Pro Asp Arg Val Leu Val Arg Val
        35                  40                  45              
Arg Asp Leu Thr Ile Gln Lys Ala Asp Glu Val Val Trp Val Arg Ala
    50                  55                  60                  
Arg Val His Thr Ser Arg Ala Lys Gly Lys Gln Cys Phe Leu Val Leu
65                  70                  75                  80  
Arg Gln Gln Gln Phe Asn Val Gln Ala Leu Val Ala Val Gly Asp His
                85                  90                  95      
Ala Ser Lys Gln Met Val Lys Phe Ala Ala Asn Ile Asn Lys Glu Ser
            100                 105                 110         
Ile Val Asp Val Glu Gly Val Val Arg Lys Val Asn Gln Lys Ile Gly
        115                 120                 125             
Ser Cys Thr Gln Gln Asp Val Glu Leu His Val Gln Lys Ile Tyr Val
    130                 135                 140                 
Ile Ser Leu Ala Glu Pro Arg Leu Pro Leu Gln Leu Asp Asp Ala Val
145                 150                 155                 160 
Arg Pro Glu Ala Glu Gly Glu Glu Glu Gly Arg Ala Thr Val Asn Gln
                165                 170                 175     
Asp Thr Arg Leu Asp Asn Arg Val Ile Asp Leu Arg Thr Ser Thr Ser
            180                 185                 190         
Gln Ala Val Phe Arg Leu Gln Ser Gly Ile Cys His Leu Phe Arg Glu
        195                 200                 205             
Thr Leu Ile Asn Lys Gly Phe Val Glu Ile Gln Thr Pro Lys Ile Ile
    210                 215                 220                 
Ser Ala Ala Ser Glu Gly Gly Ala Asn Val Phe Thr Val Ser Tyr Phe
225                 230                 235                 240 
Lys Asn Asn Ala Tyr Leu Ala Gln Ser Pro Gln Leu Tyr Lys Gln Met
                245                 250                 255     
Cys Ile Cys Ala Asp Phe Glu Lys Val Phe Ser Ile Gly Pro Val Phe
            260                 265                 270         
Arg Ala Glu Asp Ser Asn Thr His Arg His Leu Thr Glu Phe Val Gly
        275                 280                 285             
Leu Asp Ile Glu Met Ala Phe Asn Tyr His Tyr His Glu Val Met Glu
    290                 295                 300                 
Glu Ile Ala Asp Thr Met Val Gln Ile Phe Lys Gly Leu Gln Glu Arg
305                 310                 315                 320 
Phe Gln Thr Glu Ile Gln Thr Val Asn Lys Gln Phe Pro Cys Glu Pro
                325                 330                 335     
Phe Lys Phe Leu Glu Pro Thr Leu Arg Leu Glu Tyr Cys Glu Ala Leu
            340                 345                 350         
Ala Met Leu Arg Glu Ala Gly Val Glu Met Gly Asp Glu Asp Asp Leu
        355                 360                 365             
Ser Thr Pro Asn Glu Lys Leu Leu Gly His Leu Val Lys Glu Lys Tyr
    370                 375                 380                 
Asp Thr Asp Phe Tyr Ile Leu Asp Lys Tyr Pro Leu Ala Val Arg Pro
385                 390                 395                 400 
Phe Tyr Thr Met Pro Asp Pro Arg Asn Pro Lys Gln Ser Asn Ser Tyr
                405                 410                 415     
Asp Met Phe Met Arg Gly Glu Glu Ile Leu Ser Gly Ala Gln Arg Ile
            420                 425                 430         
His Asp Pro Gln Leu Leu Thr Glu Arg Ala Leu His His Gly Ile Asp
        435                 440                 445             
Leu Glu Lys Ile Lys Ala Tyr Ile Asp Ser Phe Arg Phe Gly Ala Pro
    450                 455                 460                 
Pro His Ala Gly Gly Gly Ile Gly Leu Glu Arg Val Thr Met Leu Phe
465                 470                 475                 480 
Leu Gly Leu His Asn Val Arg Gln Thr Ser Met Phe Pro Arg Asp Pro
                485                 490                 495     
Lys Arg Leu Thr Pro
            500     


<210> 106
<211> 471
<212> PRT
<213> Homo sapiens

<400> 106
Met Pro Asn Ser Glu Pro Ala Ser Leu Leu Glu Leu Phe Asn Ser Ile
 1               5                  10                  15      
Ala Thr Gln Gly Glu Leu Val Arg Ser Leu Lys Ala Gly Asn Ala Ser
            20                  25                  30          
Lys Asp Glu Ile Asp Ser Ala Val Lys Met Leu Val Ser Leu Lys Met
        35                  40                  45              
Ser Tyr Lys Ala Ala Ala Gly Glu Asp Tyr Lys Ala Asp Cys Pro Pro
    50                  55                  60                  
Gly Asn Pro Ala Pro Thr Ser Asn His Gly Pro Asp Ala Thr Glu Ala
65                  70                  75                  80  
Glu Glu Asp Phe Val Asp Pro Trp Thr Val Gln Thr Ser Ser Ala Lys
                85                  90                  95      
Gly Ile Asp Tyr Asp Lys Leu Ile Val Arg Phe Gly Ser Ser Lys Ile
            100                 105                 110         
Asp Lys Glu Leu Ile Asn Arg Ile Glu Arg Ala Thr Gly Gln Arg Pro
        115                 120                 125             
His His Phe Leu Arg Arg Gly Ile Phe Phe Ser His Arg Asp Met Asn
    130                 135                 140                 
Gln Val Leu Asp Ala Tyr Glu Asn Lys Lys Pro Phe Tyr Leu Tyr Thr
145                 150                 155                 160 
Gly Arg Gly Pro Ser Ser Glu Ala Met His Val Gly His Leu Ile Pro
                165                 170                 175     
Phe Ile Phe Thr Lys Trp Leu Gln Asp Val Phe Asn Val Pro Leu Val
            180                 185                 190         
Ile Gln Met Thr Asp Asp Glu Lys Tyr Leu Trp Lys Asp Leu Thr Leu
        195                 200                 205             
Asp Gln Ala Tyr Ser Tyr Ala Val Glu Asn Ala Lys Asp Ile Ile Ala
    210                 215                 220                 
Cys Gly Phe Asp Ile Asn Lys Thr Phe Ile Phe Ser Asp Leu Asp Tyr
225                 230                 235                 240 
Met Gly Met Ser Ser Gly Phe Tyr Lys Asn Val Val Lys Ile Gln Lys
                245                 250                 255     
His Val Thr Phe Asn Gln Val Lys Gly Ile Phe Gly Phe Thr Asp Ser
            260                 265                 270         
Asp Cys Ile Gly Lys Ile Ser Phe Pro Ala Ile Gln Ala Ala Pro Ser
        275                 280                 285             
Phe Ser Asn Ser Phe Pro Gln Ile Phe Arg Asp Arg Thr Asp Ile Gln
    290                 295                 300                 
Cys Leu Ile Pro Cys Ala Ile Asp Gln Asp Pro Tyr Phe Arg Met Thr
305                 310                 315                 320 
Arg Asp Val Ala Pro Arg Ile Gly Tyr Pro Lys Pro Ala Leu Leu His
                325                 330                 335     
Ser Thr Phe Phe Pro Ala Leu Gln Gly Ala Gln Thr Lys Met Ser Ala
            340                 345                 350         
Ser Asp Pro Asn Ser Ser Ile Phe Leu Thr Asp Thr Ala Lys Gln Ile
        355                 360                 365             
Lys Thr Lys Val Asn Lys His Ala Phe Ser Gly Gly Arg Asp Thr Ile
    370                 375                 380                 
Glu Glu His Arg Gln Phe Gly Gly Asn Cys Asp Val Asp Val Ser Phe
385                 390                 395                 400 
Met Tyr Leu Thr Phe Phe Leu Glu Asp Asp Asp Lys Leu Glu Gln Ile
                405                 410                 415     
Arg Lys Asp Tyr Thr Ser Gly Ala Met Leu Thr Gly Glu Leu Lys Lys
            420                 425                 430         
Ala Leu Ile Glu Val Leu Gln Pro Leu Ile Ala Glu His Gln Ala Arg
        435                 440                 445             
Arg Lys Glu Val Thr Asp Glu Ile Val Lys Glu Phe Met Thr Pro Arg
    450                 455                 460                 
Lys Leu Ser Phe Asp Phe Gln
465                 470     


<210> 107
<211> 424
<212> PRT
<213> Homo sapiens

<400> 107
Met Ser Tyr Lys Ala Ala Ala Gly Glu Asp Tyr Lys Ala Asp Cys Pro
 1               5                  10                  15      
Pro Gly Asn Pro Ala Pro Thr Ser Asn His Gly Pro Asp Ala Thr Glu
            20                  25                  30          
Ala Glu Glu Asp Phe Val Asp Pro Trp Thr Val Gln Thr Ser Ser Ala
        35                  40                  45              
Lys Gly Ile Asp Tyr Asp Lys Leu Ile Val Arg Phe Gly Ser Ser Lys
    50                  55                  60                  
Ile Asp Lys Glu Leu Ile Asn Arg Ile Glu Arg Ala Thr Gly Gln Arg
65                  70                  75                  80  
Pro His His Phe Leu Arg Arg Gly Ile Phe Phe Ser His Arg Asp Met
                85                  90                  95      
Asn Gln Val Leu Asp Ala Tyr Glu Asn Lys Lys Pro Phe Tyr Leu Tyr
            100                 105                 110         
Thr Gly Arg Gly Pro Ser Ser Glu Ala Met His Val Gly His Leu Ile
        115                 120                 125             
Pro Phe Ile Phe Thr Lys Trp Leu Gln Asp Val Phe Asn Val Pro Leu
    130                 135                 140                 
Val Ile Gln Met Thr Asp Asp Glu Lys Tyr Leu Trp Lys Asp Leu Thr
145                 150                 155                 160 
Leu Asp Gln Ala Tyr Ser Tyr Ala Val Glu Asn Ala Lys Asp Ile Ile
                165                 170                 175     
Ala Cys Gly Phe Asp Ile Asn Lys Thr Phe Ile Phe Ser Asp Leu Asp
            180                 185                 190         
Tyr Met Gly Met Ser Ser Gly Phe Tyr Lys Asn Val Val Lys Ile Gln
        195                 200                 205             
Lys His Val Thr Phe Asn Gln Val Lys Gly Ile Phe Gly Phe Thr Asp
    210                 215                 220                 
Ser Asp Cys Ile Gly Lys Ile Ser Phe Pro Ala Ile Gln Ala Ala Pro
225                 230                 235                 240 
Ser Phe Ser Asn Ser Phe Pro Gln Ile Phe Arg Asp Arg Thr Asp Ile
                245                 250                 255     
Gln Cys Leu Ile Pro Cys Ala Ile Asp Gln Asp Pro Tyr Phe Arg Met
            260                 265                 270         
Thr Arg Asp Val Ala Pro Arg Ile Gly Tyr Pro Lys Pro Ala Leu Leu
        275                 280                 285             
His Ser Thr Phe Phe Pro Ala Leu Gln Gly Ala Gln Thr Lys Met Ser
    290                 295                 300                 
Ala Ser Asp Pro Asn Ser Ser Ile Phe Leu Thr Asp Thr Ala Lys Gln
305                 310                 315                 320 
Ile Lys Thr Lys Val Asn Lys His Ala Phe Ser Gly Gly Arg Asp Thr
                325                 330                 335     
Ile Glu Glu His Arg Gln Phe Gly Gly Asn Cys Asp Val Asp Val Ser
            340                 345                 350         
Phe Met Tyr Leu Thr Phe Phe Leu Glu Asp Asp Asp Lys Leu Glu Gln
        355                 360                 365             
Ile Arg Lys Asp Tyr Thr Ser Gly Ala Met Leu Thr Gly Glu Leu Lys
    370                 375                 380                 
Lys Ala Leu Ile Glu Val Leu Gln Pro Leu Ile Ala Glu His Gln Ala
385                 390                 395                 400 
Arg Arg Lys Glu Val Thr Asp Glu Ile Val Lys Glu Phe Met Thr Pro
                405                 410                 415     
Arg Lys Leu Ser Phe Asp Phe Gln
            420                 


<210> 108
<211> 401
<212> PRT
<213> Homo sapiens

<400> 108
Ser Asn His Gly Pro Asp Ala Thr Glu Ala Glu Glu Asp Phe Val Asp
 1               5                  10                  15      
Pro Trp Thr Val Gln Thr Ser Ser Ala Lys Gly Ile Asp Tyr Asp Lys
            20                  25                  30          
Leu Ile Val Arg Phe Gly Ser Ser Lys Ile Asp Lys Glu Leu Ile Asn
        35                  40                  45              
Arg Ile Glu Arg Ala Thr Gly Gln Arg Pro His His Phe Leu Arg Arg
    50                  55                  60                  
Gly Ile Phe Phe Ser His Arg Asp Met Asn Gln Val Leu Asp Ala Tyr
65                  70                  75                  80  
Glu Asn Lys Lys Pro Phe Tyr Leu Tyr Thr Gly Arg Gly Pro Ser Ser
                85                  90                  95      
Glu Ala Met His Val Gly His Leu Ile Pro Phe Ile Phe Thr Lys Trp
            100                 105                 110         
Leu Gln Asp Val Phe Asn Val Pro Leu Val Ile Gln Met Thr Asp Asp
        115                 120                 125             
Glu Lys Tyr Leu Trp Lys Asp Leu Thr Leu Asp Gln Ala Tyr Ser Tyr
    130                 135                 140                 
Ala Val Glu Asn Ala Lys Asp Ile Ile Ala Cys Gly Phe Asp Ile Asn
145                 150                 155                 160 
Lys Thr Phe Ile Phe Ser Asp Leu Asp Tyr Met Gly Met Ser Ser Gly
                165                 170                 175     
Phe Tyr Lys Asn Val Val Lys Ile Gln Lys His Val Thr Phe Asn Gln
            180                 185                 190         
Val Lys Gly Ile Phe Gly Phe Thr Asp Ser Asp Cys Ile Gly Lys Ile
        195                 200                 205             
Ser Phe Pro Ala Ile Gln Ala Ala Pro Ser Phe Ser Asn Ser Phe Pro
    210                 215                 220                 
Gln Ile Phe Arg Asp Arg Thr Asp Ile Gln Cys Leu Ile Pro Cys Ala
225                 230                 235                 240 
Ile Asp Gln Asp Pro Tyr Phe Arg Met Thr Arg Asp Val Ala Pro Arg
                245                 250                 255     
Ile Gly Tyr Pro Lys Pro Ala Leu Leu His Ser Thr Phe Phe Pro Ala
            260                 265                 270         
Leu Gln Gly Ala Gln Thr Lys Met Ser Ala Ser Asp Pro Asn Ser Ser
        275                 280                 285             
Ile Phe Leu Thr Asp Thr Ala Lys Gln Ile Lys Thr Lys Val Asn Lys
    290                 295                 300                 
His Ala Phe Ser Gly Gly Arg Asp Thr Ile Glu Glu His Arg Gln Phe
305                 310                 315                 320 
Gly Gly Asn Cys Asp Val Asp Val Ser Phe Met Tyr Leu Thr Phe Phe
                325                 330                 335     
Leu Glu Asp Asp Asp Lys Leu Glu Gln Ile Arg Lys Asp Tyr Thr Ser
            340                 345                 350         
Gly Ala Met Leu Thr Gly Glu Leu Lys Lys Ala Leu Ile Glu Val Leu
        355                 360                 365             
Gln Pro Leu Ile Ala Glu His Gln Ala Arg Arg Lys Glu Val Thr Asp
    370                 375                 380                 
Glu Ile Val Lys Glu Phe Met Thr Pro Arg Lys Leu Ser Phe Asp Phe
385                 390                 395                 400 
Gln


<210> 109
<211> 25
<212> PRT
<213> Homo sapiens

<400> 109
Asn Ser Ala Leu Ser Ala Gln Leu Arg Glu Ala Ala Thr Gln Ala Gln
 1               5                  10                  15      
Gln Thr Leu Gly Ser Thr Ile Asp Lys
            20                  25  


<210> 110
<211> 37
<212> PRT
<213> Homo sapiens

<400> 110
Ser His Pro Leu Asp Pro Ile Asp Thr Val Asp Phe Glu Arg Glu Cys
 1               5                  10                  15      
Gly Val Gly Val Ile Val Thr Pro Glu Gln Ile Glu Glu Ala Val Glu
            20                  25                  30          
Ala Ala Ile Asn Arg
        35          


<210> 111
<211> 11
<212> PRT
<213> Homo sapiens

<400> 111
Leu Ser Phe Leu Val Ser Tyr Ile Ala Ser Lys
 1               5                  10      


<210> 112
<211> 23
<212> PRT
<213> Homo sapiens

<400> 112
Glu Cys Gly Val Gly Val Ile Val Thr Pro Glu Gln Ile Glu Glu Ala
 1               5                  10                  15      
Val Glu Ala Ala Ile Asn Arg
            20              


<210> 113
<211> 28
<212> PRT
<213> Homo sapiens

<400> 113
Glu Ala Ala Thr Gln Ala Gln Gln Thr Leu Gly Ser Thr Ile Asp Lys
 1               5                  10                  15      
Ala Thr Gly Ile Leu Leu Tyr Gly Leu Ala Ser Arg
            20                  25              


<210> 114
<211> 15
<212> PRT
<213> Homo sapiens

<400> 114
Ile His Thr Glu Pro Gln Leu Ser Ala Ala Leu Glu Tyr Val Arg
 1               5                  10                  15  


<210> 115
<211> 14
<212> PRT
<213> Homo sapiens

<400> 115
Asn Glu Val Asp Met Gln Val Leu His Leu Leu Gly Pro Lys
 1               5                  10 

<210> 116
<211> 775
<212> PRT
<213> Mus musculus

<400> 116
Met Ala Thr Pro Asp Ser Leu Ala Leu Phe Thr Gly Leu Gly Leu Ser
 1               5                  10                  15      
Glu Asn Lys Ala Arg Glu Thr Leu Lys Asn Glu Ala Leu Ser Thr Gln
            20                  25                  30          
Leu Arg Glu Ala Ala Thr Gln Ala His Gln Ile Leu Gly Ser Thr Ile
        35                  40                  45              
Asp Lys Ala Thr Gly Val Leu Leu Tyr Asp Leu Val Ser Arg Leu Arg
    50                  55                  60                  
Asp Thr Arg Arg Arg Ser Phe Leu Val Ser Tyr Ile Ala Asn Lys Lys
65                  70                  75                  80  
Ile His Thr Gly Leu Gln Leu Ser Ala Ala Leu Glu Tyr Val Arg Ser
                85                  90                  95      
His Pro Gln Asp Pro Ile Asp Thr Lys Asp Phe Glu Gln Glu Cys Gly
            100                 105                 110         
Val Gly Val Val Val Thr Pro Glu Gln Ile Glu Glu Ala Val Glu Ser
        115                 120                 125             
Thr Ile Asn Lys His Gln Leu Gln Leu Leu Ala Glu Arg Tyr Arg Phe
    130                 135                 140                 
Asn Met Gly Leu Leu Met Gly Glu Ala Arg Ala Ala Leu Arg Trp Ala
145                 150                 155                 160 
Asp Gly Lys Met Ile Lys Asn Glu Val Asp Met Gln Val Leu His Leu
                165                 170                 175     
Leu Gly Pro Lys Met Glu Ala Asp Leu Val Lys Lys Pro Lys Val Ala
            180                 185                 190         
Lys Ala Arg Leu Glu Glu Thr Asp Arg Lys Thr Ala Lys Asp Val Val
        195                 200                 205             
Glu Lys Gly Glu Val Ala Gly Gln Ile Leu Ser Leu Met Glu Gln Leu
    210                 215                 220                 
Arg Gly Glu Ala Leu Lys Phe His Lys Pro Gly Glu Asn Tyr Lys Thr
225                 230                 235                 240 
Pro Gly Tyr Val Ile Thr Pro Tyr Thr Met Asp Leu Leu Lys Gln His
                245                 250                 255     
Leu Glu Ile Thr Gly Gly Gln Val Arg Thr Arg Phe Pro Pro Glu Pro
            260                 265                 270         
Asn Gly Ile Leu His Ile Gly His Ala Lys Ala Ile Asn Phe Asn Phe
        275                 280                 285             
Gly Tyr Ala Lys Ala Asn Asn Gly Ile Cys Phe Leu Arg Phe Asp Asp
    290                 295                 300                 
Thr Asn Pro Glu Lys Glu Glu Ala Lys Phe Phe Thr Ala Ile Tyr Asp
305                 310                 315                 320 
Met Val Thr Trp Leu Gly Tyr Thr Pro Tyr Lys Val Thr Tyr Ala Ser
                325                 330                 335     
Asp Tyr Phe Asp Gln Leu Tyr Ala Trp Ala Val Glu Leu Ile His Gly
            340                 345                 350         
Gly Leu Ala Tyr Val Cys His Gln Arg Val Glu Glu Leu Lys Gly His
        355                 360                 365             
Asn Pro Leu Pro Ser Pro Trp Arg Asp Arg Pro Lys Glu Glu Ser Leu
    370                 375                 380                 
Leu Leu Phe Glu Ala Met Arg Lys Gly Lys Phe Ala Glu Gly Glu Ala
385                 390                 395                 400 
Thr Leu Arg Met Lys Leu Val Met Glu Asp Gly Lys Met Asp Pro Val
                405                 410                 415     
Ala Tyr Arg Val Lys Tyr Thr Pro His His Arg Thr Gly Asp Lys Trp
            420                 425                 430         
Cys Ile Tyr Pro Thr Tyr Asp Tyr Thr His Cys Leu Cys Asp Ser Ile
        435                 440                 445             
Glu His Ile Thr His Ser Leu Cys Thr Lys Glu Phe Gln Ala Arg Arg
    450                 455                 460                 
Ser Ser Tyr Phe Trp Leu Cys Asn Ala Leu Lys Val Tyr Cys Pro Val
465                 470                 475                 480 
Gln Trp Glu Tyr Gly Arg Leu Asn Leu His Tyr Ala Val Val Ser Lys
                485                 490                 495     
Arg Lys Ile Leu Gln Leu Val Ala Ala Gly Ala Val Arg Asp Trp Asp
            500                 505                 510         
Asp Pro Arg Leu Phe Thr Leu Thr Ala Leu Arg Arg Arg Gly Phe Pro
        515                 520                 525             
Pro Glu Ala Ile Asn Asn Phe Cys Ala Arg Val Gly Val Thr Val Ala
    530                 535                 540                 
Gln Thr Thr Met Glu Pro His Leu Leu Glu Ala Cys Val Arg Asp Val
545                 550                 555                 560 
Leu Asn Asp Ala Ala Pro Arg Ala Met Ala Val Leu Glu Pro Leu Gln
                565                 570                 575     
Val Val Ile Thr Asn Phe Pro Ala Pro Lys Pro Leu Asp Ile Arg Val
            580                 585                 590         
Pro Asn Phe Pro Ala Asp Glu Thr Lys Gly Phe His Gln Val Pro Phe
        595                 600                 605             
Ala Ser Thr Val Phe Ile Glu Arg Ser Asp Phe Lys Glu Glu Ser Glu
    610                 615                 620                 
Pro Gly Tyr Lys Arg Leu Ala Ser Gly Gln Pro Val Gly Leu Arg His
625                 630                 635                 640 
Thr Gly Tyr Val Ile Glu Leu Gln Asn Ile Val Arg Gly Ser Ser Gly
                645                 650                 655     
Cys Val Glu Arg Leu Glu Val Thr Cys Arg Arg Ala Asp Ala Gly Glu
            660                 665                 670         
Lys Pro Lys Ala Phe Ile His Trp Val Ser Gln Pro Leu Val Cys Glu
        675                 680                 685             
Ile Arg Leu Tyr Glu Arg Leu Phe Gln His Lys Asn Pro Glu Asp Pro
    690                 695                 700                 
Val Glu Val Pro Gly Gly Phe Leu Ser Asp Leu Asn Pro Ala Ser Leu
705                 710                 715                 720 
Gln Val Val Glu Gly Ala Leu Val Asp Cys Ser Val Ala Leu Ala Lys
                725                 730                 735     
Pro Phe Asp Lys Phe Gln Phe Glu Arg Leu Gly Tyr Phe Ser Val Asp
            740                 745                 750         
Pro Asp Ser His Gln Gly Gln Ile Val Phe Asn Arg Thr Val Thr Leu
        755                 760                 765             
Lys Glu Asp Pro Gly Glu Ile
    770                 775 

<210> 117
<211> 2437
<212> DNA
<213> Homo sapiens

<400> 117
ctgcaatggc ggctctagac tccctgtcgc tcttcactag cctcggcctg agcgagcaga 60
aggcccgcga gacgctcaag aactcggctc tgagcgcgca gctgcgcgag gccgctactc 120
aggctcagca gaccctgggt tccaccattg acaaagctac cgggatcctg ttatatggct 180
tggcctcccg actcagggat acccggcgtc tctccttcct tgtaagctac atagccagta 240
agaagatcca cactgagccc cagctaagcg ctgcccttga gtatgtgcgg agtcacccct 300
tggaccccat cgacactgtg gacttcgagc gggaatgtgg cgtgggtgtc attgtgaccc 360
cagagcagat tgaggaggct gtggaggctg ctattaacag gcaccggccc cagctcctgg 420
tggaacgtta ccatttcaac atggggctgc tgatgggaga ggctcgggct gtgctgaagt 480
gggcagatgg caaaatgatc aagaatgaag tggacatgca ggtcctccac cttctgggcc 540
ccaagttgga ggctgatctg gagaagaagt tcaaggtggc aaaagctcgg ctagaagaaa 600
cagaccggag gacggcaaag gatgtggtgg agaatggcga gactgctgac cagaccctgt 660
ctctgatgga gcagctccgg ggggaggccc ttaagttcca caagcctggt gagaactaca 720
agaccccagg ctatgtggtc actccacaca ccatgaatct actaaagcag cacctggaga 780
ttactggtgg gcaggtacgt acccggttcc cgccagaacc caatggaatc ctgcatattg 840
gacatgccaa agccatcaat ttcaactttg gctatgccaa ggccaacaat ggcatctgtt 900
ttctgcgttt tgatgacacc aaccctgaga aggaggaagc aaagttcttc acggccatct 960
gtgacatggt agcctggcta ggctacacac cttacaaagt cacatatgcg tctgactatt 1020
ttgaccagct atatgcgtgg gctgtggagc tcatccgcag gggtctggct tatgtgtgcc 1080
accagcgagg agaggagctc aaaggccata atactctgcc ttcaccctgg agagaccgtc 1140
ccatggagga gtcactgctg ctctttgagg caatgcgcaa gggcaagttt tcagagggcg 1200
aggccacact acggatgaag ctggtgatgg aggatggcaa gatggaccct gtagcctatc 1260
gagtcaagta tacaccacac caccgcacag gggacaaatg gtgcatctat cccacctacg 1320
actacacaca ctgcctctgt gactccatcg agcacatcac tcactcactc tgcaccaagg 1380
aattccaggc ccgacgctct tcctacttct ggctttgcaa tgcactggac gtctattgcc 1440
ctgtgcagtg ggagtatggc cgcctcaacc tgcactatgc tgttgtctct aagaggaaga 1500
tcctccagct tgtagcaact ggtgctgtgc gggactggga tgacccacgg ctctttacac 1560
tcacggccct gcgacggcgg ggcttcccac ctgaggccat caacaacttc tgtgcccggg 1620
tgggagtgac tgtggcacaa accacaatgg agccacatct tctagaagcc tgtgtgcgtg 1680
atgtgctgaa tgacacagcc ccacgagcca tggctgtgct ggagtcacta cgggtcatca 1740
tcaccaactt tcctgctgcc aagtccttgg acatccaggt gcccaacttc ccagctgatg 1800
agaccaaagg cttccatcag gttccctttg cacccattgt cttcattgag aggactgact 1860
tcaaggagga gccagagcca ggatttaagc gcctggcttg gggccagcct gtgggcctga 1920
ggcatacagg ctacgtcatt gagctgcagc atgttgtcaa gggccccagt ggttgtgtag 1980
agagtctgga ggtgacctgc agacgggcag atgctggaga gaagccaaag gcctttattc 2040
actgggtgtc acagcctttg atgtgtgagg ttcgcctcta tgagcgacta ttccagcaca 2100
agaaccctga agatcctact gaggtgcctg gtggattttt aagtgacctg aacctggcat 2160
cactacacgt ggtggatgca gcattagtgg actgctctgt ggccctggca aaacccttcg 2220
acaagttcca gtttgagcgt cttggatatt tctccgtgga tccagacagc catcagggaa 2280
agcttgtctt taaccgaact gtcacactga aggaagaccc aggaaaggtg tgagctggaa 2340
gcactgaacc tacctcatcc tcctggaggg tgtggctacc ctcgccaccc caaattccat 2400
gtcaataaag aacagctaaa ttctcctaga aaaaaaa                          2437
                 

   