
                                SEQUENCE LISTING

<110> Redinbo, Matthew R.
      Mani, Sridhar

<120> COMPOSITIONS AND METHODS FOR SELECTIVELY
  INHIBITING BACTERIAL B-GLUCURONIDASES AND FOR ALLEVIATING
  SIDE EFFECTS ASSOCIATED WITH CAMPTOTHECIN-DERIVED
  ANTINEOPLASTIC AGENTS OR GLUCURONIDASE-SUBSTRATE AGENTS OR
  COMPOUNDS

<130> 035052/399495

<150> 61/285,265          
<151> 2009-12-10  

<150> 61/408,032          
<151> 2010-10-29  

<160> 2

<170> FastSEQ for Windows Version 4.0

<210> 1
<211> 603
<212> PRT
<213> Escherichia coli

<400> 1
His Leu Arg Pro Val Glu Thr Pro Thr Arg Glu Ile Lys Lys Leu Asp
 1               5                  10                  15      
Gly Leu Trp Ala Phe Ser Leu Asp Arg Glu Asn Cys Gly Ile Asp Gln
            20                  25                  30          
Arg Trp Trp Glu Ser Ala Leu Gln Glu Ser Arg Ala Ile Ala Val Pro
        35                  40                  45              
Gly Ser Phe Asn Asp Gln Phe Ala Asp Ala Asp Ile Arg Asn Tyr Val
    50                  55                  60                  
Gly Asn Val Trp Tyr Gln Arg Glu Val Phe Ile Pro Lys Gly Trp Ala
65                  70                  75                  80  
Gly Gln Arg Ile Val Leu Arg Phe Asp Ala Val Thr His Tyr Gly Lys
                85                  90                  95      
Val Trp Val Asn Asn Gln Glu Val His Glu His Gln Gly Gly Tyr Thr
            100                 105                 110         
Pro Phe Glu Ala Asp Val Thr Pro Tyr Val Ile Ala Gly Lys Ser Val
        115                 120                 125             
Arg Ile Thr Val Cys Val Asn Asn Glu Leu Asn Trp Gln Thr Ile Pro
    130                 135                 140                 
Pro Gly His Val Ile Thr Asp Glu Asn Gly Lys Lys Lys Gln Ser Tyr
145                 150                 155                 160 
Phe His Asp Phe Phe Asn Tyr Ala Gly Ile His Arg Ser Val His Leu
                165                 170                 175     
Tyr Thr Thr Pro Asn Thr Trp Val Asp Asp Ile Thr Val Val Thr His
            180                 185                 190         
Val Ala Gln Asp Cys Asn His Ala Ser Val Asp Trp Gln Val Gly Ala
        195                 200                 205             
Asn Gly Asp Val Ser Val Glu Leu Arg Asp Ala Asp Gln Gln Val Val
    210                 215                 220                 
Ala Thr Gly Gln Gly Thr Ser Gly Thr Leu Gln Val Val Asn Pro His
225                 230                 235                 240 
Leu Trp Gln Pro Gly Glu Gly Tyr Leu Tyr Glu Leu Cys Val Thr Ala
                245                 250                 255     
Lys Ser Gln Thr Glu Cys Asp Ile Tyr Leu Leu Arg Val Gly Ile Arg
            260                 265                 270         
Ser Val Ala Val Lys Gly Glu Gln Phe Leu Ile Asn His Lys Pro Phe
        275                 280                 285             
Tyr Phe Thr Gly Phe Gly Arg His Glu Asp Ala Asp Leu Arg Gly Lys
    290                 295                 300                 
Gly Phe Asp Asn Val Leu His Val His Asp His Ala Leu His Asp Trp
305                 310                 315                 320 
Ile Gly Ala Asn Ser Tyr Arg Thr Ser His Tyr Pro Tyr Ala Glu Glu
                325                 330                 335     
His Leu Asp Trp Ala Asp Glu His Gly Ile Val Val Ile Asp Glu Thr
            340                 345                 350         
Ala Ala Val Gly Phe Asn Leu Ser Leu Gly Ile Gly Phe Glu Ala Gly
        355                 360                 365             
Asn Lys Pro Lys Glu Leu Tyr Ser Glu Glu Ala Val Asn Gly Glu Thr
    370                 375                 380                 
Gln Gln Ala His Leu Gln Ala Ile Lys Glu Leu Ile Ala Arg Asp Lys
385                 390                 395                 400 
Asn His Pro Ser Val Val His Trp Ser Ile Ala Asn Glu Pro Asp Thr
                405                 410                 415     
Arg Pro Gln Gly Ala Arg Glu Tyr Phe Ala Pro Leu Ala Glu Ala Thr
            420                 425                 430         
Arg Lys Leu Asp Pro Thr Arg Pro Ile Thr Cys Val Asn Val His Phe
        435                 440                 445             
Cys Asp Ala His Thr Asp Thr Ile Ser Asp Leu Phe Asp Val Leu Cys
    450                 455                 460                 
Leu Asn Arg Tyr Tyr Gly Trp Tyr Val Gln Ser Gly Asp Leu Glu Thr
465                 470                 475                 480 
Ala Glu Lys Val Leu Glu Lys Glu Leu Leu Ala Trp Gln Glu Lys Leu
                485                 490                 495     
His Gln Pro Ile Ile Ile Thr Glu Tyr Gly Val Asp Thr Leu Ala Gly
            500                 505                 510         
Leu His Ser His Tyr Thr Asp His Trp Ser Glu Glu Tyr Gln Cys Ala
        515                 520                 525             
Trp Leu Asp His Tyr His Arg Val Phe Asp Arg Val Ser Ala Val Val
    530                 535                 540                 
Gly Glu Gln Val Trp Asn Phe Ala Asp Phe Ala Thr Ser Gln Gly Ile
545                 550                 555                 560 
Leu Arg Val Gly Gly Asn Lys Lys Gly Ile Phe Thr Arg Asp Arg Lys
                565                 570                 575     
Pro Lys Ser Ala Ala Phe Leu Leu Gln Lys Arg Trp Thr Gly His Asn
            580                 585                 590         
Phe Gly Glu Lys Pro Gln Gln Gly Gly Lys Gln
        595                 600             


<210> 2
<211> 613
<212> PRT
<213> Homo sapiens

<400> 2
Leu Gly Leu Gln Gly Gly His Leu Tyr Pro Gln Glu Ser Pro Ser Arg
 1               5                  10                  15      
Glu Cys Lys Glu Leu Asp Gly Leu Trp Ser Phe Arg Ala Asp Phe Ser
            20                  25                  30          
Asp Asn Arg Arg Arg Gly Phe Glu Glu Gln Trp Tyr Arg Arg Pro Leu
        35                  40                  45              
Trp Glu Ser Gly Pro Thr Val Asp His Pro Val Pro Ser Ser Phe Asn
    50                  55                  60                  
Asp Ile Ser Gln Asp Trp Arg Leu Arg His Phe Val Gly Trp Val Trp
65                  70                  75                  80  
Tyr Glu Arg Glu Val Ile Leu Pro Glu Arg Trp Thr Gln Asp Leu Arg
                85                  90                  95      
Thr Arg Val Val Leu Arg Ile Gly Ser Ala His Ser Tyr Ala Ile Val
            100                 105                 110         
Trp Val Asn Gly Val Asp Thr Leu Glu His Glu Gly Gly Tyr Leu Pro
        115                 120                 125             
Phe Glu Ala Asp Ile Ser Asn Leu Val Gln Val Gly Pro Leu Pro Ser
    130                 135                 140                 
Arg Leu Arg Ile Thr Ile Ala Ile Asn Asn Thr Leu Thr Pro Thr Thr
145                 150                 155                 160 
Leu Pro Pro Gly Thr Ile Gln Tyr Leu Thr Asp Thr Ser Lys Tyr Pro
                165                 170                 175     
Lys Gly Tyr Phe Val Gln Asn Thr Tyr Phe Asp Phe Phe Asn Tyr Ala
            180                 185                 190         
Gly Leu Gln Arg Ser Val Leu Leu Tyr Thr Thr Pro Thr Thr Tyr Ile
        195                 200                 205             
Asp Asp Ile Thr Val Thr Thr Ser Val Glu Gln Asp Ser Gly Leu Val
    210                 215                 220                 
Asn Tyr Gln Ile Ser Val Lys Gly Ser Asn Leu Phe Lys Leu Glu Val
225                 230                 235                 240 
Arg Leu Leu Asp Ala Glu Asn Lys Val Val Ala Asn Gly Thr Gly Thr
                245                 250                 255     
Gln Gly Gln Leu Lys Val Pro Gly Val Ser Leu Trp Trp Pro Tyr Leu
            260                 265                 270         
His His Glu Arg Pro Ala Tyr Leu Tyr Ser Leu Glu Val Gln Leu Thr
        275                 280                 285             
Ala Gln Thr Ser Leu Gly Pro Val Ser Asp Phe Tyr Thr Leu Pro Val
    290                 295                 300                 
Gly Ile Arg Thr Val Ala Val Thr Lys Ser Gln Phe Leu Ile Asn Gly
305                 310                 315                 320 
Lys Pro Phe Tyr Phe His Gly Val Asn Lys His Glu Asp Ala Asp Ile
                325                 330                 335     
Arg Gly Lys Gly Phe Asp Trp Pro Leu Leu Val Lys Asp Phe Asn Leu
            340                 345                 350         
Leu Arg Trp Leu Gly Ala Asn Ala Phe Arg Thr Ser His Tyr Pro Tyr
        355                 360                 365             
Ala Glu Glu Val His Gln His Cys Asp Arg Tyr Gly Ile Val Val Ile
    370                 375                 380                 
Asp Glu Cys Pro Gly Val Gly Leu Ala Leu Pro Gln Phe Phe Asn Asn
385                 390                 395                 400 
Val Ser Leu His His His His Gln Val His Glu Glu Val Val Arg Arg
                405                 410                 415     
Asp Lys Asn His Pro Ala Val Val His Trp Ser Val Ala Asn Glu Pro
            420                 425                 430         
Ala Ser His Leu Glu Ser Ala Gly Tyr Tyr Leu Lys His Val Ile Ala
        435                 440                 445             
His Thr Lys Ser Leu Asp Pro Ser Arg Pro Val Thr Phe Val Ser Asn
    450                 455                 460                 
Ser Asn Tyr Ala Ala Asp Lys Gly Ala Pro Tyr Val Asp Val Ile Cys
465                 470                 475                 480 
Leu Asn Ser Tyr Tyr Ser Trp Tyr His Asp Tyr Gly His Leu Glu Leu
                485                 490                 495     
Ile Gln Leu Gln Leu Ala Thr Gln Phe Glu Asn Trp Tyr Lys Lys Tyr
            500                 505                 510         
Gln Lys Pro Ile Ile Gln Ser Glu Tyr Gly Ala Glu Thr Ile Ala Gly
        515                 520                 525             
Phe His Gln Asp Pro Pro Leu His Phe Thr Glu Glu Tyr Gln Lys Ser
    530                 535                 540                 
Leu Leu Glu Gln Tyr His Leu Gly Leu Asp Gln Lys Arg Arg Lys Tyr
545                 550                 555                 560 
Val Val Gly Glu Leu Ile Trp Asn Phe Ala Asp Phe His Thr Glu Gln
                565                 570                 575     
Ser Pro Thr Arg Val Leu Gly Asn Lys Lys Gly Ile Phe Thr Arg Gln
            580                 585                 590         
Arg Gln Pro Lys Ser Ala Ala Phe Leu Leu Arg Glu Arg Tyr Trp Lys
        595                 600                 605             
Ile Ala Asn Glu Thr
    610             

