                               SEQUENCE LISTING	

<110> ALNYLAM PHARMACEUTICALS, INC.
 
<120> COMPOSITIONS FOR NUCLEIC ACID DELIVERY

<130> 17615.0002 PCT

<140> PCT/US2010/059206
<141> 2010-12-07

<150> 61/384,303
<151> 2010-09-19

<150> 61/334,398
<151> 2010-05-13

<150> 61/267,419
<151> 2009-12-07

<160> 62    

<170> PatentIn version 3.5

<210> 1
<211> 16
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 1
taacgttgag gggcat                                                       16


<210> 2
<211> 16
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<221> modified_base
<222> (4)..(4)
<223> Methylated cytosine

<400> 2
taacgttgag gggcat                                                       16


<210> 3
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 3
tccatgacgt tcctgacgtt                                                   20


<210> 4
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<221> modified_base
<222> (8)..(8)
<223> Methylated cytosine

<220>
<221> modified_base
<222> (17)..(17)
<223> Methylated cytosine

<400> 4
tccatgacgt tcctgacgtt                                                   20


<210> 5
<211> 16
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 5
taagcatacg gggtgt                                                       16


<210> 6
<211> 6
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 6
aacgtt                                                                   6


<210> 7
<211> 24
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 7
gatgctgtgt cggggtctcc gggc                                              24


<210> 8
<211> 24
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 8
tcgtcgtttt gtcgttttgt cgtt                                              24


<210> 9
<211> 24
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<221> modified_base
<222> (2)..(2)
<223> Methylated cytosine

<220>
<221> modified_base
<222> (5)..(5)
<223> Methylated cytosine

<220>
<221> modified_base
<222> (13)..(13)
<223> Methylated cytosine

<220>
<221> modified_base
<222> (21)..(21)
<223> Methylated cytosine

<400> 9
tcgtcgtttt gtcgttttgt cgtt                                              24


<210> 10
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 10
tccaggactt ctctcaggtt                                                   20


<210> 11
<211> 18
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 11
tctcccagcg tgcgccat                                                     18


<210> 12
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 12
tgcatccccc aggccaccat                                                   20


<210> 13
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 13
gcccaagctg gcatccgtca                                                   20


<210> 14
<211> 15
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 14
ggtgctcact gcggc                                                        15


<210> 15
<211> 16
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 15
aaccgttgag gggcat                                                       16


<210> 16
<211> 24
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 16
tatgctgtgc cggggtcttc gggc                                              24


<210> 17
<211> 18
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 17
gtgccggggt cttcgggc                                                     18


<210> 18
<211> 18
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 18
ggaccctcct ccggagcc                                                     18


<210> 19
<211> 18
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 19
tcctccggag ccagactt                                                     18


<210> 20
<211> 15
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 20
aacgttgagg ggcat                                                        15


<210> 21
<211> 15
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 21
ccgtggtcat gctcc                                                        15


<210> 22
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 22
cagcctggct caccgccttg g                                                 21


<210> 23
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 23
cagccatggt tccccccaac                                                   20


<210> 24
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 24
gttctcgctg gtgagtttca                                                   20


<210> 25
<211> 18
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 25
tctcccagcg tgcgccat                                                     18


<210> 26
<211> 15
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 26
gtgctccatt gatgc                                                        15


<210> 27
<211> 33
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 27
gaguucugau gaggccgaaa ggccgaaagu cug                                    33


<210> 28
<211> 6
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 28
rrcgyy                                                                   6


<210> 29
<211> 15
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 29
aacgttgagg ggcat                                                        15


<210> 30
<211> 16
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 30
caacgttatg gggaga                                                       16


<210> 31
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 31
ttccatgacg ttcctgacgt                                                   20


<210> 32
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<221> modified_base
<222> (8)..(8)
<223> Methylated cytosine

<220>
<221> modified_base
<222> (17)..(17)
<223> Methylated cytosine

<400> 32
tccatgacgt tcctgacgt                                                    19


<210> 33
<211> 29
<212> PRT
<213> Unknown

<220>
<223> Description of Unknown: GALA peptide

<400> 33
Ala Ala Leu Glu Ala Leu Ala Glu Ala Leu Glu Ala Leu Ala Glu Ala 
1               5                   10                  15      


Leu Glu Ala Leu Ala Glu Ala Ala Ala Ala Gly Gly Cys 
            20                  25                  


<210> 34
<211> 30
<212> PRT
<213> Unknown

<220>
<223> Description of Unknown: EALA polypeptide

<400> 34
Ala Ala Leu Ala Glu Ala Leu Ala Glu Ala Leu Ala Glu Ala Leu Ala 
1               5                   10                  15      


Glu Ala Leu Ala Glu Ala Leu Ala Ala Ala Ala Gly Gly Cys 
            20                  25                  30  


<210> 35
<211> 15
<212> PRT
<213> Unknown

<220>
<223> Description of Unknown: Endosomolytic ligand polypeptide

<400> 35
Ala Leu Glu Ala Leu Ala Glu Ala Leu Glu Ala Leu Ala Glu Ala 
1               5                   10                  15  


<210> 36
<211> 22
<212> PRT
<213> Unknown

<220>
<223> Description of Unknown: INF-7 peptide

<400> 36
Gly Leu Phe Glu Ala Ile Glu Gly Phe Ile Glu Asn Gly Trp Glu Gly 
1               5                   10                  15      


Met Ile Trp Asp Tyr Gly 
            20          


<210> 37
<211> 23
<212> PRT
<213> Unknown

<220>
<223> Description of Unknown: Inf HA-2 peptide

<400> 37
Gly Leu Phe Gly Ala Ile Ala Gly Phe Ile Glu Asn Gly Trp Glu Gly 
1               5                   10                  15      


Met Ile Asp Gly Trp Tyr Gly 
            20              


<210> 38
<211> 24
<212> PRT
<213> Unknown

<220>
<223> Description of Unknown: diINF-7 peptide 

<400> 38
Gly Leu Phe Glu Ala Ile Glu Gly Phe Ile Glu Asn Gly Trp Glu Gly 
1               5                   10                  15      


Met Ile Asp Gly Trp Tyr Gly Cys 
            20                  


<210> 39
<211> 22
<212> PRT
<213> Unknown

<220>
<223> Description of Unknown: diINF3 peptide 

<400> 39
Gly Leu Phe Glu Ala Ile Glu Gly Phe Ile Glu Asn Gly Trp Glu Gly 
1               5                   10                  15      


Met Ile Asp Gly Gly Cys 
            20          


<210> 40
<211> 35
<212> PRT
<213> Unknown

<220>
<223> Description of Unknown: GLF polypeptide 

<400> 40
Gly Leu Phe Gly Ala Leu Ala Glu Ala Leu Ala Glu Ala Leu Ala Glu 
1               5                   10                  15      


His Leu Ala Glu Ala Leu Ala Glu Ala Leu Glu Ala Leu Ala Ala Gly 
            20                  25                  30          


Gly Ser Cys 
        35  


<210> 41
<211> 34
<212> PRT
<213> Unknown

<220>
<223> Description of Unknown: GALA-INF3 polypeptide

<400> 41
Gly Leu Phe Glu Ala Ile Glu Gly Phe Ile Glu Asn Gly Trp Glu Gly 
1               5                   10                  15      


Leu Ala Glu Ala Leu Ala Glu Ala Leu Glu Ala Leu Ala Ala Gly Gly 
            20                  25                  30          


Ser Cys 
        


<210> 42
<211> 21
<212> PRT
<213> Unknown

<220>
<223> Description of Unknown: INF-5 peptide 


<220>
<221> MOD_RES
<222> (17)..(17)
<223> Norleucine

<400> 42
Gly Leu Phe Glu Ala Ile Glu Gly Phe Ile Glu Asn Gly Trp Glu Gly 
1               5                   10                  15      


Leu Ile Asp Gly Lys 
            20      


<210> 43
<211> 20
<212> PRT
<213> Unknown

<220>
<223> Description of Unknown: INF-5 peptide 


<220>
<221> MOD_RES
<222> (17)..(17)
<223> Norleucine

<400> 43
Gly Leu Phe Glu Ala Ile Glu Gly Phe Ile Glu Asn Gly Trp Glu Gly 
1               5                   10                  15      


Leu Ile Asp Gly 
            20  


<210> 44
<211> 16
<212> PRT
<213> Drosophila sp.

<400> 44
Arg Gln Ile Lys Ile Trp Phe Gln Asn Arg Arg Met Lys Trp Lys Lys 
1               5                   10                  15      


<210> 45
<211> 13
<212> PRT
<213> Human immunodeficiency virus

<400> 45
Gly Arg Lys Lys Arg Arg Gln Arg Arg Arg Pro Pro Gln 
1               5                   10                  


<210> 46
<211> 27
<212> PRT
<213> Unknown

<220>
<223> Description of Unknown: Signal sequence-based
      peptide

<400> 46
Gly Ala Leu Phe Leu Gly Trp Leu Gly Ala Ala Gly Ser Thr Met Gly 
1               5                   10                  15      


Ala Trp Ser Gln Pro Lys Lys Lys Arg Lys Val 
            20                  25          


<210> 47
<211> 18
<212> PRT
<213> Unknown

<220>
<223> Description of Unknown: PVEC peptide 

<400> 47
Leu Leu Ile Ile Leu Arg Arg Arg Ile Arg Lys Gln Ala His Ala His 
1               5                   10                  15      


Ser Lys 
        


<210> 48
<211> 26
<212> PRT
<213> Unknown

<220>
<223> Description of Unknown: Transportan peptide

<400> 48
Gly Trp Thr Leu Asn Ser Ala Gly Tyr Leu Leu Lys Ile Asn Leu Lys 
1               5                   10                  15      


Ala Leu Ala Ala Leu Ala Lys Lys Ile Leu 
            20                  25      


<210> 49
<211> 18
<212> PRT
<213> Unknown

<220>
<223> Description of Unknown: Amphiphilic model peptide 

<400> 49
Lys Leu Ala Leu Lys Leu Ala Leu Lys Ala Leu Lys Ala Ala Leu Lys 
1               5                   10                  15      


Leu Ala 
        


<210> 50
<211> 9
<212> PRT
<213> Unknown

<220>
<223> Description of Unknown: Cell permeation peptide 

<400> 50
Arg Arg Arg Arg Arg Arg Arg Arg Arg 
1               5                   


<210> 51
<211> 10
<212> PRT
<213> Unknown

<220>
<223> Description of Unknown: Bacterial cell wall permeating
      peptide

<400> 51
Lys Phe Phe Lys Phe Phe Lys Phe Phe Lys 
1               5                   10  


<210> 52
<211> 37
<212> PRT
<213> Unknown

<220>
<223> Description of Unknown: LL-37 polypeptide 

<400> 52
Leu Leu Gly Asp Phe Phe Arg Lys Ser Lys Glu Lys Ile Gly Lys Glu 
1               5                   10                  15      


Phe Lys Arg Ile Val Gln Arg Ile Lys Asp Phe Leu Arg Asn Leu Val 
            20                  25                  30          


Pro Arg Thr Glu Ser 
        35          


<210> 53
<211> 31
<212> PRT
<213> Unknown

<220>
<223> Description of Unknown: Cecropin P1 polypeptide 

<400> 53
Ser Trp Leu Ser Lys Thr Ala Lys Lys Leu Glu Asn Ser Ala Lys Lys 
1               5                   10                  15      


Arg Ile Ser Glu Gly Ile Ala Ile Ala Ile Gln Gly Gly Pro Arg 
            20                  25                  30      


<210> 54
<211> 30
<212> PRT
<213> Unknown

<220>
<223> Description of Unknown: Alpha-defensin polypeptide 

<400> 54
Ala Cys Tyr Cys Arg Ile Pro Ala Cys Ile Ala Gly Glu Arg Arg Tyr 
1               5                   10                  15      


Gly Thr Cys Ile Tyr Gln Gly Arg Leu Trp Ala Phe Cys Cys 
            20                  25                  30  


<210> 55
<211> 36
<212> PRT
<213> Unknown

<220>
<223> Description of Unknown: Beta-defensin polypeptide      

<400> 55
Asp His Tyr Asn Cys Val Ser Ser Gly Gly Gln Cys Leu Tyr Ser Ala 
1               5                   10                  15      


Cys Pro Ile Phe Thr Lys Ile Gln Gly Thr Cys Tyr Arg Gly Lys Ala 
            20                  25                  30          


Lys Cys Cys Lys 
        35      


<210> 56
<211> 12
<212> PRT
<213> Unknown

<220>
<223> Description of Unknown: Bactenecin peptide

<400> 56
Arg Lys Cys Arg Ile Val Val Ile Arg Val Cys Arg 
1               5                   10          


<210> 57
<211> 42
<212> PRT
<213> Unknown

<220>
<223> Description of Unknown: PR-39 polypeptide 

<400> 57
Arg Arg Arg Pro Arg Pro Pro Tyr Leu Pro Arg Pro Arg Pro Pro Pro 
1               5                   10                  15      


Phe Phe Pro Pro Arg Leu Pro Pro Arg Ile Pro Pro Gly Phe Pro Pro 
            20                  25                  30          


Arg Phe Pro Pro Arg Phe Pro Gly Lys Arg 
        35                  40          


<210> 58
<211> 13
<212> PRT
<213> Unknown

<220>
<223> Description of Unknown: Indolicidin peptide 

<400> 58
Ile Leu Pro Trp Lys Trp Pro Trp Trp Pro Trp Arg Arg 
1               5                   10              


<210> 59
<211> 16
<212> PRT
<213> Unknown

<220>
<223> Description of Unknown: Exemplary hydrophobic MTS-containing
      peptide 

<400> 59
Ala Ala Val Ala Leu Leu Pro Ala Val Leu Leu Ala Leu Leu Ala Pro 
1               5                   10                  15      


<210> 60
<211> 11
<212> PRT
<213> Unknown

<220>
<223> Description of Unknown: Exemplary hydrophobic MTS-containing
      peptide 

<400> 60
Ala Ala Leu Leu Pro Val Leu Leu Ala Ala Pro 
1               5                   10      


<210> 61
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide

<400> 61
ucgaaguacu cagcguaagt t                                                 21


<210> 62
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide

<400> 62
cuuacgcuga guacuucgat t                                                 21


