                         SEQUENCE LISTING

<110>  PROYECTO DE BIOMEDICINA CIMA S.L.
       RESEARCH CENTER BORSTEL
 
<120>  NUEVOS CONJUGADOS Y COMPOSICIONES PARA INMUNOTERAPIA Y 
       TRATAMIENTO ANTI-TUMORAL

<130>  P5443PC00

<160>  52    

<170>  PatentIn version 3.5

<210>  1
<211>  267
<212>  PRT
<213>  Homo sapiens

<400>  1

Met Lys Ala Ala Val Leu Thr Leu Ala Val Leu Phe Leu Thr Gly Ser 
1               5                   10                  15      


Gln Ala Arg His Phe Trp Gln Gln Asp Glu Pro Pro Gln Ser Pro Trp 
            20                  25                  30          


Asp Arg Val Lys Asp Leu Ala Thr Val Tyr Val Asp Val Leu Lys Asp 
        35                  40                  45              


Ser Gly Arg Asp Tyr Val Ser Gln Phe Glu Gly Ser Ala Leu Gly Lys 
    50                  55                  60                  


Gln Leu Asn Leu Lys Leu Leu Asp Asn Trp Asp Ser Val Thr Ser Thr 
65                  70                  75                  80  


Phe Ser Lys Leu Arg Glu Gln Leu Gly Pro Val Thr Gln Glu Phe Trp 
                85                  90                  95      


Asp Asn Leu Glu Lys Glu Thr Glu Gly Leu Arg Gln Glu Met Ser Lys 
            100                 105                 110         


Asp Leu Glu Glu Val Lys Ala Lys Val Gln Pro Tyr Leu Asp Asp Phe 
        115                 120                 125             


Gln Lys Lys Trp Gln Glu Glu Met Glu Leu Tyr Arg Gln Lys Val Glu 
    130                 135                 140                 


Pro Leu Arg Ala Glu Leu Gln Glu Gly Ala Arg Gln Lys Leu His Glu 
145                 150                 155                 160 


Leu Gln Glu Lys Leu Ser Pro Leu Gly Glu Glu Met Arg Asp Arg Ala 
                165                 170                 175     


Arg Ala His Val Asp Ala Leu Arg Thr His Leu Ala Pro Tyr Ser Asp 
            180                 185                 190         


Glu Leu Arg Gln Arg Leu Ala Ala Arg Leu Glu Ala Leu Lys Glu Asn 
        195                 200                 205             


Gly Gly Ala Arg Leu Ala Glu Tyr His Ala Lys Ala Thr Glu His Leu 
    210                 215                 220                 


Ser Thr Leu Ser Glu Lys Ala Lys Pro Ala Leu Glu Asp Leu Arg Gln 
225                 230                 235                 240 


Gly Leu Leu Pro Val Leu Glu Ser Phe Lys Val Ser Phe Leu Ser Ala 
                245                 250                 255     


Leu Glu Glu Tyr Thr Lys Lys Leu Asn Thr Gln 
            260                 265         


<210>  2
<211>  264
<212>  PRT
<213>  Mus musculus

<400>  2

Met Lys Ala Val Val Leu Ala Val Ala Leu Val Phe Leu Thr Gly Ser 
1               5                   10                  15      


Gln Ala Trp His Val Trp Gln Gln Asp Glu Pro Gln Ser Gln Trp Asp 
            20                  25                  30          


Lys Val Lys Asp Phe Ala Asn Val Tyr Val Asp Ala Val Lys Asp Ser 
        35                  40                  45              


Gly Arg Asp Tyr Val Ser Gln Phe Glu Ser Ser Ser Leu Gly Gln Gln 
    50                  55                  60                  


Leu Asn Leu Asn Leu Leu Glu Asn Trp Asp Thr Leu Gly Ser Thr Val 
65                  70                  75                  80  


Ser Gln Leu Gln Glu Arg Leu Gly Pro Leu Thr Arg Asp Phe Trp Asp 
                85                  90                  95      


Asn Leu Glu Lys Glu Thr Asp Trp Val Arg Gln Glu Met Asn Lys Asp 
            100                 105                 110         


Leu Glu Glu Val Lys Gln Lys Val Gln Pro Tyr Leu Asp Glu Phe Gln 
        115                 120                 125             


Lys Lys Trp Lys Glu Asp Val Glu Leu Tyr Arg Gln Lys Val Ala Pro 
    130                 135                 140                 


Leu Gly Ala Glu Leu Gln Glu Ser Ala Arg Gln Lys Leu Gln Glu Leu 
145                 150                 155                 160 


Gln Gly Arg Leu Ser Pro Val Ala Glu Glu Phe Arg Asp Arg Met Arg 
                165                 170                 175     


Thr His Val Asp Ser Leu Arg Thr Gln Leu Ala Pro His Ser Glu Gln 
            180                 185                 190         


Met Arg Glu Ser Leu Ala Gln Arg Leu Ala Glu Leu Lys Ser Asn Pro 
        195                 200                 205             


Thr Leu Asn Glu Tyr His Thr Arg Ala Lys Thr His Leu Lys Thr Leu 
    210                 215                 220                 


Gly Glu Lys Ala Arg Pro Ala Leu Glu Asp Leu Arg His Ser Leu Met 
225                 230                 235                 240 


Pro Met Leu Glu Thr Leu Lys Thr Lys Ala Gln Ser Val Ile Asp Lys 
                245                 250                 255     


Ala Ser Glu Thr Leu Thr Ala Gln 
            260                 


<210>  3
<211>  259
<212>  PRT
<213>  Rattus norvegicus

<400>  3

Met Lys Ala Ala Val Leu Ala Val Ala Leu Val Phe Leu Thr Gly Cys 
1               5                   10                  15      


Gln Ala Trp Glu Phe Trp Gln Gln Asp Glu Pro Gln Ser Gln Trp Asp 
            20                  25                  30          


Arg Val Lys Asp Phe Ala Thr Val Tyr Val Asp Ala Val Lys Asp Ser 
        35                  40                  45              


Gly Arg Asp Tyr Val Ser Gln Phe Glu Ser Ser Thr Leu Gly Lys Gln 
    50                  55                  60                  


Leu Asn Leu Asn Leu Leu Asp Asn Trp Asp Thr Leu Gly Ser Thr Val 
65                  70                  75                  80  


Gly Arg Leu Gln Glu Gln Leu Gly Pro Val Thr Gln Glu Phe Trp Ala 
                85                  90                  95      


Asn Leu Glu Lys Glu Thr Asp Trp Leu Arg Asn Glu Met Asn Lys Asp 
            100                 105                 110         


Leu Glu Asn Val Lys Gln Lys Met Gln Pro His Leu Asp Glu Phe Gln 
        115                 120                 125             


Glu Lys Trp Asn Glu Glu Val Glu Ala Tyr Arg Gln Lys Leu Glu Pro 
    130                 135                 140                 


Leu Gly Thr Glu Leu His Lys Asn Ala Lys Glu Met Gln Arg His Leu 
145                 150                 155                 160 


Lys Val Val Ala Glu Glu Phe Arg Asp Arg Met Arg Val Asn Ala Asp 
                165                 170                 175     


Ala Leu Arg Ala Lys Phe Gly Leu Tyr Ser Asp Gln Met Arg Glu Asn 
            180                 185                 190         


Leu Ala Gln Arg Leu Thr Glu Ile Lys Asn His Pro Thr Leu Ile Glu 
        195                 200                 205             


Tyr His Thr Lys Ala Ser Asp His Leu Lys Thr Leu Gly Glu Lys Ala 
    210                 215                 220                 


Lys Pro Ala Leu Asp Asp Leu Gly Gln Gly Leu Met Pro Val Leu Glu 
225                 230                 235                 240 


Ala Trp Lys Ala Lys Ile Met Ser Met Ile Asp Glu Ala Lys Lys Lys 
                245                 250                 255     


Leu Asn Ala 
            


<210>  4
<211>  965
<212>  DNA
<213>  Homo sapiens

<400>  4
gaattcaaaa aaaaaagaaa aaaaaaaaaa aaaaaaaaaa aaaaaaagag agactgcgag       60

aaggaggtcc cccacggccc ttcaggatga aagctgcggt gctgaccttg gccgtgctct      120

tcctgacggg gagccaggct cggcatttct ggcagcaaga tgaacccccc cagagcccct      180

gggatcgagt gaaggacctg gccactgtgt acgtggatgt gctcaaagac agcggcagag      240

actatgtgtc ccagtttgaa ggctccgcct tgggaaaaca gctaaaccta aagctccttg      300

acaactggga cagcgtgacc tccaccttca gcaagctgcg cgaacagctc ggccctgtga      360

cccaggagtt ctgggataac ctggaaaagg agacagaggg cctgaggcag gagatgagca      420

aggatctgga ggaggtgaag gccaaggtgc agccctacct ggacgacttc cagaagaagt      480

ggcaggagga gatggagctc taccgccaga aggtggagcc gctgcgcgca gagctccaag      540

agggcgcgcg ccagaagctg cacgagctgc aagagaagct gagcccactg ggcgaggaga      600

tgcgcgaccg cgcgcgcgcc catgtggacg cgctgcgcac gcatctggcc ccctacagcg      660

acgagctgcg ccagcgcttg gccgcgcgcc ttgaggctct caaggagaac ggcggcgcca      720

gactggccga gtaccacgcc aaggccaccg agcatctgag cacgctcagc gagaaggcca      780

agcccgcgct cgaggacctc cgccaaggcc tgctgcccgt gctggagagc ttcaaggtca      840

gcttcctgag cgctctcgag gagtacacta agaagctcaa cacccagtga ggcgcccgcc      900

gccgcccccc ttcccggtgc tcagaataaa cgtttccaaa gtgggaaaaa aaaaaaaaag      960

aattc                                                                  965


<210>  5
<211>  924
<212>  DNA
<213>  Mus musculus

<400>  5
accccagact gtcggagagc tccggggagg tcacccacac ccttcaggat gaaagctgtg       60

gtgctggccg tggctctggt cttcctgaca gggagccagg cttggcacgt atggcagcaa      120

gatgaacccc agtcccaatg ggacaaagtg aaggatttcg ctaatgtgta tgtggatgcg      180

gtcaaagaca gcggcagaga ctatgtgtcc cagtttgaat cctcctcctt gggccaacag      240

ctgaacctga atctcctgga aaactgggac actctgggtt caaccgttag tcagctgcag      300

gaacggctgg gcccattgac tcgggacttc tgggataacc tggagaaaga aacagattgg      360

gtgagacagg agatgaacaa ggacctagag gaagtgaaac agaaggtgca gccctacctg      420

gacgaattcc agaagaaatg gaaagaggat gtggagctct accgccagaa ggtggcgcct      480

ctgggcgccg agctgcagga gagcgcgcgc cagaagctgc aggagctgca agggagactg      540

tcccctgtgg ctgaggaatt tcgcgaccgc atgcgcacac acgtagactc tctgcgcaca      600

cagctagcgc cccacagcga acagatgcgc gagagcctgg cccagcgcct ggctgagctc      660

aagagcaacc ctaccttgaa cgagtaccac accagggcca aaacccacct gaagacactt      720

ggcgagaaag ccagacctgc gctggaggac ctgcgccata gtctgatgcc catgctggag      780

acgcttaaga ccaaagccca gagtgtgatc gacaaggcca gcgagactct gactgcccag      840

tgaggtgccc gcttccactc cccacccccg cattggcttt cttacaataa acctttccaa      900

aatggaaaaa aaaaaaaaaa aaaa                                             924


<210>  6
<211>  889
<212>  DNA
<213>  Rattus norvegicus

<400>  6
agactgttgg agagctccgg gggaggtcgc cacatccttc aggatgaaag ctgcagtgtt       60

ggctgtggcc ctggtcttcc tgacaggttg ccaagcttgg gagttctggc agcaagatga      120

gccccagtcc caatgggaca gggtgaagga tttcgccact gtgtatgtgg atgcagtcaa      180

ggacagcggc agagactatg tgtcccagtt tgaatcctcc actttgggca aacagctgaa      240

cctgaatctc ctggacaact gggacactct gggttcaact gttggtcgcc tacaggaaca      300

gctaggccca gtgactcagg agttctgggc taacctggag aaagaaacag attggctgag      360

aaacgagatg aacaaggacc tggagaatgt gaaacagaag atgcagcccc acctggatga      420

attccaggag aagtggaacg aggaggtcga ggcctaccgc cagaagctgg agcctctggg      480

caccgagctt cacaaaaacg cgaaggagat gcaaaggcat ctaaaggttg tggccgagga      540

gtttcgagac cgcatgcgtg tgaatgcaga cgcgctgcgc gcaaagtttg ggctctacag      600

cgatcagatg cgcgagaacc tggcccagcg cctgaccgag atcaagaacc accctaccct      660

gatcgagtat cataccaagg ccagcgacca cctgaagaca cttggtgaga aagccaaacc      720

cgcgctggat gacctgggcc agggcctgat gccggtgctg gaagcctgga aggccaaaat      780

catgagtatg atcgatgagg ccaaaaagaa gctgaacgct tagtgaggcg cccgtcacca      840

ctccccaccc ctgaattggc tttcttacaa taaacgtttc caaagtggg                  889


<210>  7
<211>  162
<212>  PRT
<213>  Homo sapiens

<400>  7

Met Arg Ile Ser Lys Pro His Leu Arg Ser Ile Ser Ile Gln Cys Tyr 
1               5                   10                  15      


Leu Cys Leu Leu Leu Asn Ser His Phe Leu Thr Glu Ala Gly Ile His 
            20                  25                  30          


Val Phe Ile Leu Gly Cys Phe Ser Ala Gly Leu Pro Lys Thr Glu Ala 
        35                  40                  45              


Asn Trp Val Asn Val Ile Ser Asp Leu Lys Lys Ile Glu Asp Leu Ile 
    50                  55                  60                  


Gln Ser Met His Ile Asp Ala Thr Leu Tyr Thr Glu Ser Asp Val His 
65                  70                  75                  80  


Pro Ser Cys Lys Val Thr Ala Met Lys Cys Phe Leu Leu Glu Leu Gln 
                85                  90                  95      


Val Ile Ser Leu Glu Ser Gly Asp Ala Ser Ile His Asp Thr Val Glu 
            100                 105                 110         


Asn Leu Ile Ile Leu Ala Asn Asn Ser Leu Ser Ser Asn Gly Asn Val 
        115                 120                 125             


Thr Glu Ser Gly Cys Lys Glu Cys Glu Glu Leu Glu Glu Lys Asn Ile 
    130                 135                 140                 


Lys Glu Phe Leu Gln Ser Phe Val His Ile Val Gln Met Phe Ile Asn 
145                 150                 155                 160 


Thr Ser 
        


<210>  8
<211>  162
<212>  PRT
<213>  Mus musculus

<400>  8

Met Lys Ile Leu Lys Pro Tyr Met Arg Asn Thr Ser Ile Ser Cys Tyr 
1               5                   10                  15      


Leu Cys Phe Leu Leu Asn Ser His Phe Leu Thr Glu Ala Gly Ile His 
            20                  25                  30          


Val Phe Ile Leu Gly Cys Val Ser Val Gly Leu Pro Lys Thr Glu Ala 
        35                  40                  45              


Asn Trp Ile Asp Val Arg Tyr Asp Leu Glu Lys Ile Glu Ser Leu Ile 
    50                  55                  60                  


Gln Ser Ile His Ile Asp Thr Thr Leu Tyr Thr Asp Ser Asp Phe His 
65                  70                  75                  80  


Pro Ser Cys Lys Val Thr Ala Met Asn Cys Phe Leu Leu Glu Leu Gln 
                85                  90                  95      


Val Ile Leu His Glu Tyr Ser Asn Met Thr Leu Asn Glu Thr Val Arg 
            100                 105                 110         


Asn Val Leu Tyr Leu Ala Asn Ser Thr Leu Ser Ser Asn Lys Asn Val 
        115                 120                 125             


Ala Glu Ser Gly Cys Lys Glu Cys Glu Glu Leu Glu Glu Lys Thr Phe 
    130                 135                 140                 


Thr Glu Phe Leu Gln Ser Phe Ile Arg Ile Val Gln Met Phe Ile Asn 
145                 150                 155                 160 


Thr Ser 
        


<210>  9
<211>  162
<212>  PRT
<213>  Rattus norvegicus

<400>  9

Met Lys Ile Leu Lys Pro Tyr Met Arg Asn Thr Ser Ile Leu Tyr Tyr 
1               5                   10                  15      


Leu Cys Phe Leu Leu Asn Ser His Phe Leu Thr Glu Ala Gly Ile His 
            20                  25                  30          


Val Phe Ile Leu Gly Cys Val Ser Val Gly Leu Pro Lys Thr Glu Ala 
        35                  40                  45              


Asn Trp Ile Asp Val Arg Tyr Asp Leu Glu Lys Ile Glu Ser Leu Ile 
    50                  55                  60                  


Gln Phe Ile His Ile Asp Thr Thr Leu Tyr Thr Asp Ser Asp Phe His 
65                  70                  75                  80  


Pro Ser Cys Lys Val Thr Ala Met Asn Cys Phe Leu Leu Glu Leu Gln 
                85                  90                  95      


Val Ile Leu His Glu Tyr Ser Asn Met Thr Leu Asn Glu Thr Val Arg 
            100                 105                 110         


Asn Val Leu Tyr Leu Ala Asn Ser Thr Leu Ser Ser Asn Lys Asn Val 
        115                 120                 125             


Ile Glu Ser Gly Cys Lys Glu Cys Glu Glu Leu Glu Glu Arg Asn Phe 
    130                 135                 140                 


Thr Glu Phe Leu Gln Ser Phe Ile His Ile Val Gln Met Phe Ile Asn 
145                 150                 155                 160 


Thr Ser 
        


<210>  10
<211>  162
<212>  PRT
<213>  Felis catus

<400>  10

Met Arg Ile Leu Lys Pro Tyr Leu Arg Ser Thr Ser Ile Gln Cys Tyr 
1               5                   10                  15      


Leu Cys Leu Leu Leu Asn Ser His Phe Leu Thr Glu Ala Cys Ile Pro 
            20                  25                  30          


Val Phe Ile Leu Ser Cys Ile Asn Ala Gly Leu Pro Lys Thr Glu Ala 
        35                  40                  45              


Asn Trp Gln Asp Val Ile Ser Asp Leu Lys Ile Ile Asp Lys Ile Ile 
    50                  55                  60                  


Gln Ser Leu His Ile Asp Ala Thr Leu Tyr Thr Glu Ser Asp Val His 
65                  70                  75                  80  


Pro Asn Cys Lys Val Thr Ala Met Lys Cys Phe Leu Leu Glu Leu His 
                85                  90                  95      


Val Ile Ser Leu Glu Ser Lys Asn Glu Thr Ile His Gln Thr Val Glu 
            100                 105                 110         


Asn Ile Ile Ile Leu Ala Asn Ser Gly Leu Ser Ser Asn Arg Asn Ile 
        115                 120                 125             


Thr Glu Thr Gly Cys Lys Glu Cys Glu Glu Leu Glu Glu Lys Asn Ile 
    130                 135                 140                 


Lys Glu Phe Leu Gln Ser Phe Val His Ile Val Gln Met Phe Ile Asn 
145                 150                 155                 160 


Thr Ser 
        


<210>  11
<211>  162
<212>  PRT
<213>  Bos taurus

<400>  11

Met Arg Ile Leu Lys Pro Tyr Leu Arg Ser Thr Ser Ile Gln Cys Tyr 
1               5                   10                  15      


Leu Cys Leu Leu Leu Asn Ser His Phe Leu Thr Glu Ala Gly Ile His 
            20                  25                  30          


Val Phe Ile Leu Gly Cys Ile Ser Ala Ser Leu Pro Lys Thr Glu Ala 
        35                  40                  45              


Asn Trp Gln Tyr Val Ile Asn Asp Leu Lys Thr Ile Glu His Leu Ile 
    50                  55                  60                  


Gln Ser Ile His Met Asp Ala Thr Leu Tyr Thr Glu Ser Asp Ala His 
65                  70                  75                  80  


Pro Asn Cys Lys Val Thr Ala Met Gln Cys Phe Leu Leu Glu Leu Arg 
                85                  90                  95      


Val Ile Leu His Glu Ser Lys Asn Ala Thr Ile Tyr Glu Ile Ile Glu 
            100                 105                 110         


Asn Leu Thr Met Leu Ala Asn Ser Asn Leu Ser Ser Ile Glu Asn Lys 
        115                 120                 125             


Thr Glu Leu Gly Cys Lys Glu Cys Glu Glu Leu Glu Glu Lys Ser Ile 
    130                 135                 140                 


Lys Glu Phe Leu Lys Ser Phe Val His Ile Val Gln Met Phe Ile Asn 
145                 150                 155                 160 


Thr Ser 
        


<210>  12
<211>  411
<212>  DNA
<213>  Artificial

<220>
<223>  Secuencia que codifica un polipptido que comprende la IL15 
       humana


<220>
<221>  misc_feature
<222>  (1)..(66)
<223>  Secuencia que codifica el pptido seal de la cadena IgV-ji

<220>
<221>  mis_feature
<222>  (67)..(411)
<223>  Secuencia que codifica la IL15 humana madura (NM_172174.2 REGION:
       990 ..1331)

<400>  12
atggattttc aggtgcagat tttcagcttc ctgctaatca gtgcctcagt cataatgtct       60

agagccaact gggtgaatgt aataagtgat ttgaaaaaaa ttgaagatct tattcaatct      120

atgcatattg atgctacttt atatacggaa agtgatgttc accccagttg caaagtaaca      180

gcaatgaagt gctttctctt ggagttacaa gttatttcac ttgagtccgg agatgcaagt      240

attcatgata cagtagaaaa tctgatcatc ctagcaaaca acagtttgtc ttctaatggg      300

aatgtaacag aatctggatg caaagaatgt gaggaactgg aggaaaaaaa tattaaagaa      360

tttttgcaga gttttgtaca tattgtccaa atgttcatca acacttcttg a               411


<210>  13
<211>  489
<212>  DNA
<213>  Mus musculus

<400>  13
atgaaaattt tgaaaccata tatgaggaat acatccatct cgtgctactt gtgtttcctt       60

ctaaacagtc actttttaac tgaggctggc attcatgtct tcattttggg ctgtgtcagt      120

gtaggtctcc ctaaaacaga ggccaactgg atagatgtaa gatatgacct ggagaaaatt      180

gaaagcctta ttcaatctat tcatattgac accactttat acactgacag tgactttcat      240

cccagttgca aagttactgc aatgaactgc tttctcctgg aattgcaggt tattttacat      300

gagtacagta acatgactct taatgaaaca gtaagaaacg tgctctacct tgcaaacagc      360

actctgtctt ctaacaagaa tgtagcagaa tctggctgca aggaatgtga ggagctggag      420

gagaaaacct tcacagagtt tttgcaaagc tttatacgca ttgtccaaat gttcatcaac      480

acgtcctga                                                              489


<210>  14
<211>  489
<212>  DNA
<213>  Rattus norvegicus

<400>  14
atgaaaattt tgaaaccata tatgaggaat acatccatct tgtactacct gtgtttcctt       60

ctcaacagtc acttcttaac tgaggctggc atccatgtct tcattttggg ctgtgtcagt      120

gtaggtctcc ctaaaacaga ggccaactgg atagatgtaa gatacgatct ggagaaaatt      180

gaaagtctta ttcaatttat tcatattgat actactctat acactgacag tgactttcat      240

cccagttgca aagttactgc aatgaactgc tttctcctgg aattacaggt tattttgcac      300

gagtacagta acatgactct taatgaaaca gtaagaaacg tgctctacct tgcaaacagc      360

actctgtctt ctaacaagaa tgtaatagag tctggctgca aggaatgtga ggagctggag      420

gagagaaact tcacggagtt tttgcagagt tttatacata ttgtccaaat gttcatcaac      480

acgtcctga                                                              489


<210>  15
<211>  489
<212>  DNA
<213>  Felis catus

<400>  15
atgagaattt tgaaaccata tttgagaagt acttccatcc agtgctactt gtgtttactt       60

ctgaacagcc attttttaac tgaagcttgc attcctgttt tcattttgag ctgtattaat      120

gcaggtcttc ctaaaacaga ggcaaactgg caggatgtaa taagtgattt gaaaataatt      180

gacaagatta ttcaatcctt acatatcgat gccactttat atactgaaag tgatgttcat      240

cccaattgca aagtaacagc gatgaagtgc tttctcctgg agttacatgt tatttcgctt      300

gagtccaaaa atgagaccat tcatcaaaca gtagaaaaca ttattatcct ggcaaacagt      360

ggtttatctt ctaacaggaa tataactgaa acaggatgca aagaatgtga ggaactggag      420

gaaaagaaca ttaaagaatt tctgcagagt tttgtacata ttgtacaaat gttcatcaac      480

acttcttga                                                              489


<210>  16
<211>  489
<212>  DNA
<213>  Bos taurus

<400>  16
atgagaattt tgaaaccata tttgagaagt acttccatcc agtgctactt gtgtttactt       60

ctgaacagtc attttttaac agaggctggc attcatgtct tcattttggg ctgtatcagt      120

gcaagtcttc ccaaaacaga agcaaactgg cagtatgtaa taaatgattt gaaaacaatt      180

gagcatctta ttcaatctat acatatggat gccactttat atactgaaag tgatgctcat      240

cccaattgca aagtaacagc gatgcagtgc tttctcctgg agttacgagt tattttacac      300

gagtccaaaa atgccaccat ttatgaaata atagaaaatc ttaccatgct agcaaacagc      360

aatttatctt ctattgagaa taaaacagaa ttgggatgca aagaatgtga ggaactggag      420

gaaaaaagta tcaaagaatt tttgaagagt tttgtacata ttgtgcaaat gttcatcaac      480

acttcttga                                                              489


<210>  17
<211>  61
<212>  PRT
<213>  Homo sapiens

<400>  17

Cys Pro Pro Pro Met Ser Val Glu His Ala Asp Ile Trp Val Lys Ser 
1               5                   10                  15      


Tyr Ser Leu Tyr Ser Arg Glu Arg Tyr Ile Cys Asn Ser Gly Phe Lys 
            20                  25                  30          


Arg Lys Ala Gly Thr Ser Ser Leu Thr Glu Cys Val Leu Asn Lys Ala 
        35                  40                  45              


Thr Asn Val Ala His Trp Thr Thr Pro Ser Leu Lys Cys 
    50                  55                  60      


<210>  18
<211>  61
<212>  PRT
<213>  Mus musculus

<400>  18

Cys Pro Pro Pro Val Ser Ile Glu His Ala Asp Ile Arg Val Lys Asn 
1               5                   10                  15      


Tyr Ser Val Asn Ser Arg Glu Arg Tyr Val Cys Asn Ser Gly Phe Lys 
            20                  25                  30          


Arg Lys Ala Gly Thr Ser Thr Leu Ile Glu Cys Val Ile Asn Lys Asn 
        35                  40                  45              


Thr Asn Val Ala His Trp Thr Thr Pro Ser Leu Lys Cys 
    50                  55                  60      


<210>  19
<211>  291
<212>  DNA
<213>  Artificial

<220>
<223>  Secuencia que codifica un polipptido que comprende el dominio 
       Sushi de la subunidad alfa del receptor de  IL15 humano (IL15RA)


<220>
<221>  misc_feature
<222>  (1)..(288)
<223>  Secuencia que codifica el pptido seal y el dominio Sushi de la 
       subunidad alfa del receptor de  IL15 humano (IL15RA) (NM_002189.2
       REGION: 83 ..371)

<400>  19
atggccccgc ggcgggcgcg cggctgccgg accctcggtc tcccggcgct gctactgctg       60

ctgctgctcc ggccgccggc gacgcggggc atcacgtgcc ctccccccat gtccgtggaa      120

cacgcagaca tctgggtcaa gagctacagc ttgtactcca gggagcggta catttgtaac      180

tctggtttca agcgtaaagc cggcacgtcc agcctgacgg agtgcgtgtt gaacaaggcc      240

acgaatgtcg cccactggac aacccccagt ctcaaatgca ttagagactg a               291


<210>  20
<211>  273
<212>  DNA
<213>  Artificial

<220>
<223>  Secuencia que codifica un polipptido que comprende el dominio 
       Sushi del Receptor IL15alfa murino (Il15ra)


<220>
<221>  misc_features
<222>  (1)..(64)
<223>  Secuencia que codifica un pptido seal de Ig-kappa

<220>
<221>  misc_features
<222>  (65)..(273)
<223>  Secuencia que codifica el dominio Sushi de la subunidad alpha del
       receptor de la IL15 (Il15ra) murino

<400>  20
atggagacag acaccctgct gctctgggtg ctgctgctgt gggtgcccgg ctctaccggc       60

gacggcacca cctgccctcc ccctgtgtcc atcgagcacg ccgacatcag agtgaagaac      120

tactccgtga actctcggga gagatacgtg tgcaactccg gcttcaagcg gaaggccggc      180

acctccaccc tgatcgagtg cgtgatcaac aagaacacca acgtggccca ctggaccacc      240

ccttccctga agtgcatccg ggacccttcc tga                                   273


<210>  21
<211>  279
<212>  DNA
<213>  Homo sapiens

<400>  21
atggccccgc ggcgggcgcg cggctgccgg accctcggtc tcccggcgct gctactgctg       60

ctgctgctcc ggccgccggc gacgcggggc atcacgtgcc ctccccccat gtccgtggaa      120

cacgcagaca tctgggtcaa gagctacagc ttgtactcca gggagcggta catttgtaac      180

tctggtttca agcgtaaagc cggcacgtcc agcctgacgg agtgcgtgtt gaacaaggcc      240

acgaatgtcg cccactggac aacccccagt ctcaaatgc                             279


<210>  22
<211>  93
<212>  PRT
<213>  Homo sapiens

<400>  22

Met Ala Pro Arg Arg Ala Arg Gly Cys Arg Thr Leu Gly Leu Pro Ala 
1               5                   10                  15      


Leu Leu Leu Leu Leu Leu Leu Arg Pro Pro Ala Thr Arg Gly Ile Thr 
            20                  25                  30          


Cys Pro Pro Pro Met Ser Val Glu His Ala Asp Ile Trp Val Lys Ser 
        35                  40                  45              


Tyr Ser Leu Tyr Ser Arg Glu Arg Tyr Ile Cys Asn Ser Gly Phe Lys 
    50                  55                  60                  


Arg Lys Ala Gly Thr Ser Ser Leu Thr Glu Cys Val Leu Asn Lys Ala 
65                  70                  75                  80  


Thr Asn Val Ala His Trp Thr Thr Pro Ser Leu Lys Cys 
                85                  90              


<210>  23
<211>  14
<212>  PRT
<213>  Artificial

<220>
<223>  Enlazador

<400>  23

Ser Gly Gly Thr Ser Gly Ser Thr Ser Gly Thr Gly Ser Thr 
1               5                   10                  


<210>  24
<211>  15
<212>  PRT
<213>  Artificial

<220>
<223>  Enlazador

<400>  24

Ala Gly Ser Ser Thr Gly Ser Ser Thr Gly Pro Gly Ser Thr Thr 
1               5                   10                  15  


<210>  25
<211>  7
<212>  PRT
<213>  Artificial

<220>
<223>  Enlazador

<400>  25

Gly Gly Ser Gly Gly Ala Pro 
1               5           


<210>  26
<211>  8
<212>  PRT
<213>  Artificial

<220>
<223>  Enlazador

<400>  26

Gly Gly Gly Val Glu Gly Gly Gly 
1               5               


<210>  27
<211>  7
<212>  PRT
<213>  Artificial

<220>
<223>  Enlazador

<400>  27

Gly Thr Lys Val His Met Lys 
1               5           


<210>  28
<211>  13
<212>  PRT
<213>  Artificial

<220>
<223>  Enlazador

<400>  28

Pro Gly Thr Ser Gly Gln Gln Pro Ser Val Gly Gln Gln 
1               5                   10              


<210>  29
<211>  5
<212>  PRT
<213>  Artificial

<220>
<223>  Enlazador

<400>  29

Gly Thr Ser Gly Gln 
1               5   


<210>  30
<211>  10
<212>  PRT
<213>  Artificial

<220>
<223>  Enlazador

<400>  30

Pro Lys Pro Ser Thr Pro Pro Gly Ser Ser 
1               5                   10  


<210>  31
<211>  11
<212>  PRT
<213>  Artificial

<220>
<223>  Enlazador

<400>  31

Ala Pro Ala Glu Thr Lys Ala Glu Pro Met Thr 
1               5                   10      


<210>  32
<211>  19
<212>  PRT
<213>  Artificial

<220>
<223>  Enlazador

<400>  32

Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Gly 
1               5                   10                  15      


Ser Leu Gln 
            


<210>  33
<211>  5
<212>  PRT
<213>  Artificial

<220>
<223>  Sitio de cote de enteroquinasa

<400>  33

Asp Asp Asp Asp Lys 
1               5   


<210>  34
<211>  5
<212>  PRT
<213>  Artificial

<220>
<223>  Sitio de corte de Factor Xa

<400>  34

Ile Glu Asp Gly Arg 
1               5   


<210>  35
<211>  6
<212>  PRT
<213>  Artificial

<220>
<223>  Sitio de corte de trombina

<400>  35

Leu Val Pro Arg Gly Ser 
1               5       


<210>  36
<211>  7
<212>  PRT
<213>  Artificial

<220>
<223>  Sitio de corte de proteasa TEV

<400>  36

Glu Asn Leu Tyr Phe Gln Gly 
1               5           


<210>  37
<211>  8
<212>  PRT
<213>  Artificial

<220>
<223>  Sitio de corte de proteasa PreScission

<400>  37

Leu Glu Val Leu Phe Gln Gly Pro 
1               5               


<210>  38
<211>  5
<212>  PRT
<213>  Artificial

<220>
<223>  Sitio de corte de MMP9

<400>  38

Leu Phe Pro Thr Ser 
1               5   


<210>  39
<211>  1155
<212>  DNA
<213>  Artificial

<220>
<223>  Secuencia que codifica la protena de fusin hApo-hIL15


<220>
<221>  misc_feature
<222>  (1)..(801)
<223>  Secuencia que codifica la apolipoprotena A-I humana (APOA1) 
       (NM_000039.1 REGION: 39..839)

<220>
<221>  misc_feature
<222>  (802)..(810)
<223>  Secuencia que codifica el enlazador GAP

<220>
<221>  misc_feature
<222>  (811)..(1153)
<223>  Secuencia que codifica la IL15 humana madura (NM_172174.2 REGION:
       990 ..1331)

<400>  39
atgaaagctg cggtgctgac cttggccgtg ctcttcctga cggggagcca ggctcggcat       60

ttctggcagc aagatgaacc cccccagagc ccctgggatc gagtgaagga cctggccact      120

gtgtacgtgg atgtgctcaa agacagcggc agagactatg tgtcccagtt tgaaggctcc      180

gccttgggaa aacagctaaa cctaaagctc cttgacaact gggacagcgt gacctccacc      240

ttcagcaagc tgcgcgaaca gctcggccct gtgacccagg agttctggga taacctggaa      300

aaggagacag agggcctgag gcaggagatg agcaaggatc tggaggaggt gaaggccaag      360

gtgcagccct acctggacga cttccagaag aagtggcagg aggagatgga gctctaccgc      420

cagaaggtgg agccgctgcg cgcagagctc caagagggcg cgcgccagaa gctgcacgag      480

ctgcaagaga agctgagccc actgggcgag gagatgcgcg accgcgcgcg cgcccatgtg      540

gacgcgctgc gcacgcatct ggccccctac agcgacgagc tgcgccagcg cttggccgcg      600

cgccttgagg ctctcaagga gaacggcggc gccagactgg ccgagtacca cgccaaggcc      660

accgagcatc tgagcacgct cagcgagaag gccaagcccg cgctcgagga cctccgccaa      720

ggcctgctgc ccgtgctgga gagcttcaag gtcagcttcc tgagcgctct cgaggagtac      780

actaagaagc tcaacaccca gggcgcgccc aactgggtga atgtaataag tgatttgaaa      840

aaaattgaag atcttattca atctatgcat attgatgcta ctttatatac ggaaagtgat      900

gttcacccca gttgcaaagt aacagcaatg aagtgctttc tcttggagtt acaagttatt      960

tcacttgagt ccggagatgc aagtattcat gatacagtag aaaatctgat catcctagca     1020

aacaacagtt tgtcttctaa tgggaatgta acagaatctg gatgcaaaga atgtgaggaa     1080

ctggaggaaa aaaatattaa agaatttttg cagagttttg tacatattgt ccaaatgttc     1140

atcaacactt cttga                                                      1155


<210>  40
<211>  1146
<212>  DNA
<213>  Artificial

<220>
<223>  Secuencia que codifica una protena de fusin mApo-hIL15


<220>
<221>  misc_feature
<222>  (1)..(792)
<223>  Secuencia que codifica la apolipoprotena A-I murina (Apoa1) 
       (NM_009692.2 REGION: 47 .. 838)

<220>
<221>  misc_feature
<222>  (793)..(800)
<223>  Secuencia que codifica el enlazador GAP

<220>
<221>  misc_feature
<222>  (801)..(1143)
<223>  Secuencia que codifica la IL15 humana madura (NM_172174.2 REGION:
       990 ..1331)

<400>  40
atgaaagctg tggtgctggc cgtggctctg gtcttcctga cagggagcca ggcttggcac       60

gtatggcagc aagatgaacc ccagtcccaa tgggacaaag tgaaggattt cgctaatgtg      120

tatgtggatg cggtcaaaga cagcggcaga gactatgtgt cccagtttga atcctcctcc      180

ttgggccaac agctgaacct gaatctcctg gaaaactggg acactctggg ttcaaccgtt      240

agtcagctgc aggaacggct gggcccattg actcgggact tctgggataa cctggagaaa      300

gaaacagatt gggtgagaca ggagatgaac aaggacctag aggaagtgaa acagaaggtg      360

cagccctacc tggacgaatt ccagaagaaa tggaaagagg atgtggagct ctaccgccag      420

aaggtggcgc ctctgggcgc cgagctgcag gagagcgcgc gccagaagct gcaggagctg      480

caagggagac tgtcccctgt ggctgaggaa tttcgcgacc gcatgcgcac acacgtagac      540

tctctgcgca cacagctagc gccccacagc gaacagatgc gcgagagcct ggcccagcgc      600

ctggctgagc tcaagagcaa ccctaccttg aacgagtacc acaccagggc caaaacccac      660

ctgaagacac ttggcgagaa agccagacct gcgctggagg acctgcgcca tagtctgatg      720

cccatgctgg agacgcttaa gaccaaagcc cagagtgtga tcgacaaggc cagcgagact      780

ctgactgccc agggcgcgcc caactgggtg aatgtaataa gtgatttgaa aaaaattgaa      840

gatcttattc aatctatgca tattgatgct actttatata cggaaagtga tgttcacccc      900

agttgcaaag taacagcaat gaagtgcttt ctcttggagt tacaagttat ttcacttgag      960

tccggagatg caagtattca tgatacagta gaaaatctga tcatcctagc aaacaacagt     1020

ttgtcttcta atgggaatgt aacagaatct ggatgcaaag aatgtgagga actggaggaa     1080

aaaaatatta aagaattttt gcagagtttt gtacatattg tccaaatgtt catcaacact     1140

tcttga                                                                1146


<210>  41
<211>  1290
<212>  DNA
<213>  Artificial

<220>
<223>  mApoI-mIL15

<400>  41
atgaaagctg tggtgctggc cgtggctctg gtcttcctga cagggagcca ggcttggcac       60

gtatggcagc aagatgaacc ccagtcccaa tgggacaaag tgaaggattt cgctaatgtg      120

tatgtggatg cggtcaaaga cagcggcaga gactatgtgt cccagtttga atcctcctcc      180

ttgggccaac agctgaacct gaatctcctg gaaaactggg acactctggg ttcaaccgtt      240

agtcagctgc aggaacggct gggcccattg actcgggact tctgggataa cctggagaaa      300

gaaacagatt gggtgagaca ggagatgaac aaggacctag aggaagtgaa acagaaggtg      360

cagccctacc tggacgaatt ccagaagaaa tggaaagagg atgtggagct ctaccgccag      420

aaggtggcgc ctctgggcgc cgagctgcag gagagcgcgc gccagaagct gcaggagctg      480

caagggagac tgtcccctgt ggctgaggaa tttcgcgacc gcatgcgcac acacgtagac      540

tctctgcgca cacagctagc gccccacagc gaacagatgc gcgagagcct ggcccagcgc      600

ctggctgagc tcaagagcaa ccctaccttg aacgagtacc acaccagggc caaaacccac      660

ctgaagacac ttggcgagaa agccagacct gcgctggagg acctgcgcca tagtctgatg      720

cccatgctgg agacgcttaa gaccaaagcc cagagtgtga tcgacaaggc cagcgagact      780

ctgactgccc agggcgcgcc catgaaaatt ttgaaaccat atatgaggaa tacatccatc      840

tcgtgctact tgtgtttcct tctaaacagt cactttttaa ctgaggctgg cattcatgtc      900

ttcattttgg gctgtgtcag tgtaggtctc cctaaaacag aggccaactg gatagatgta      960

agatatgacc tggagaaaat tgaaagcctt attcaatcta ttcatattga caccacttta     1020

tacactgaca gtgactttca tcccagttgc aaagttactg caatgaactg ctttctcctg     1080

gaattgcagg ttattttaca tgagtacagt aacatgactc ttaatgaaac agtaagaaac     1140

gtgctctacc ttgcaaacag cactctgtct tctaacaaga atgtagcaga atctggctgc     1200

aaggaatgtg aggagctgga ggagaaaacc ttcacagagt ttttgcaaag ctttatacgc     1260

attgtccaaa tgttcatcaa cacgtcctga                                      1290


<210>  42
<211>  443
<212>  PRT
<213>  Artificial

<220>
<223>  hSushi-hIL15-hApoA1

<400>  42

Cys Pro Pro Pro Met Ser Val Glu His Ala Asp Ile Trp Val Lys Ser 
1               5                   10                  15      


Tyr Ser Leu Tyr Ser Arg Glu Arg Tyr Ile Cys Asn Ser Gly Phe Lys 
            20                  25                  30          


Arg Lys Ala Gly Thr Ser Ser Leu Thr Glu Cys Val Leu Asn Lys Ala 
        35                  40                  45              


Thr Asn Val Ala His Trp Thr Thr Pro Ser Leu Lys Cys Ile Arg Asp 
    50                  55                  60                  


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Gly 
65                  70                  75                  80  


Ser Leu Gln Asn Trp Val Asn Val Ile Ser Asp Leu Lys Lys Ile Glu 
                85                  90                  95      


Asp Leu Ile Gln Ser Met His Ile Asp Ala Thr Leu Tyr Thr Glu Ser 
            100                 105                 110         


Asp Val His Pro Ser Cys Lys Val Thr Ala Met Lys Cys Phe Leu Leu 
        115                 120                 125             


Glu Leu Gln Val Ile Ser Leu Glu Ser Gly Asp Ala Ser Ile His Asp 
    130                 135                 140                 


Thr Val Glu Asn Leu Ile Ile Leu Ala Asn Asn Ser Leu Ser Ser Asn 
145                 150                 155                 160 


Gly Asn Val Thr Glu Ser Gly Cys Lys Glu Cys Glu Glu Leu Glu Glu 
                165                 170                 175     


Lys Asn Ile Lys Glu Phe Leu Gln Ser Phe Val His Ile Val Gln Met 
            180                 185                 190         


Phe Ile Asn Thr Ser Gly Ala Pro Asp Glu Pro Pro Gln Ser Pro Trp 
        195                 200                 205             


Asp Arg Val Lys Asp Leu Ala Thr Val Tyr Val Asp Val Leu Lys Asp 
    210                 215                 220                 


Ser Gly Arg Asp Tyr Val Ser Gln Phe Glu Gly Ser Ala Leu Gly Lys 
225                 230                 235                 240 


Gln Leu Asn Leu Lys Leu Leu Asp Asn Trp Asp Ser Val Thr Ser Thr 
                245                 250                 255     


Phe Ser Lys Leu Arg Glu Gln Leu Gly Pro Val Thr Gln Glu Phe Trp 
            260                 265                 270         


Asp Asn Leu Glu Lys Glu Thr Glu Gly Leu Arg Gln Glu Met Ser Lys 
        275                 280                 285             


Asp Leu Glu Glu Val Lys Ala Lys Val Gln Pro Tyr Leu Asp Asp Phe 
    290                 295                 300                 


Gln Lys Lys Trp Gln Glu Glu Met Glu Leu Tyr Arg Gln Lys Val Glu 
305                 310                 315                 320 


Pro Leu Arg Ala Glu Leu Gln Glu Gly Ala Arg Gln Lys Leu His Glu 
                325                 330                 335     


Leu Gln Glu Lys Leu Ser Pro Leu Gly Glu Glu Met Arg Asp Arg Ala 
            340                 345                 350         


Arg Ala His Val Asp Ala Leu Arg Thr His Leu Ala Pro Tyr Ser Asp 
        355                 360                 365             


Glu Leu Arg Gln Arg Leu Ala Ala Arg Leu Glu Ala Leu Lys Glu Asn 
    370                 375                 380                 


Gly Gly Ala Arg Leu Ala Glu Tyr His Ala Lys Ala Thr Glu His Leu 
385                 390                 395                 400 


Ser Thr Leu Ser Glu Lys Ala Lys Pro Ala Leu Glu Asp Leu Arg Gln 
                405                 410                 415     


Gly Leu Leu Pro Val Leu Glu Ser Phe Lys Val Ser Phe Leu Ser Ala 
            420                 425                 430         


Leu Glu Glu Tyr Thr Lys Lys Leu Asn Thr Gln 
        435                 440             


<210>  43
<211>  459
<212>  PRT
<213>  Artificial

<220>
<223>  mSushi-mIL15-mApoA1

<400>  43

Cys Pro Pro Pro Val Ser Ile Glu His Ala Asp Ile Arg Val Lys Asn 
1               5                   10                  15      


Tyr Ser Val Asn Ser Arg Glu Arg Tyr Val Cys Asn Ser Gly Phe Lys 
            20                  25                  30          


Arg Lys Ala Gly Thr Ser Thr Leu Ile Glu Cys Val Ile Asn Lys Asn 
        35                  40                  45              


Thr Asn Val Ala His Trp Thr Thr Pro Ser Leu Lys Cys Gly Gly Ser 
    50                  55                  60                  


Gly Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Gly Ser Leu Gln 
65                  70                  75                  80  


Thr Glu Ala Gly Ile His Val Phe Ile Leu Gly Cys Val Ser Val Gly 
                85                  90                  95      


Leu Pro Lys Thr Glu Ala Asn Trp Ile Asp Val Arg Tyr Asp Leu Glu 
            100                 105                 110         


Lys Ile Glu Ser Leu Ile Gln Ser Ile His Ile Asp Thr Thr Leu Tyr 
        115                 120                 125             


Thr Asp Ser Asp Phe His Pro Ser Cys Lys Val Thr Ala Met Asn Cys 
    130                 135                 140                 


Phe Leu Leu Glu Leu Gln Val Ile Leu His Glu Tyr Ser Asn Met Thr 
145                 150                 155                 160 


Leu Asn Glu Thr Val Arg Asn Val Leu Tyr Leu Ala Asn Ser Thr Leu 
                165                 170                 175     


Ser Ser Asn Lys Asn Val Ala Glu Ser Gly Cys Lys Glu Cys Glu Glu 
            180                 185                 190         


Leu Glu Glu Lys Thr Phe Thr Glu Phe Leu Gln Ser Phe Ile Arg Ile 
        195                 200                 205             


Val Gln Met Phe Ile Asn Thr Ser Gly Ala Pro Asp Glu Pro Gln Ser 
    210                 215                 220                 


Gln Trp Asp Lys Val Lys Asp Phe Ala Asn Val Tyr Val Asp Ala Val 
225                 230                 235                 240 


Lys Asp Ser Gly Arg Asp Tyr Val Ser Gln Phe Glu Ser Ser Ser Leu 
                245                 250                 255     


Gly Gln Gln Leu Asn Leu Asn Leu Leu Glu Asn Trp Asp Thr Leu Gly 
            260                 265                 270         


Ser Thr Val Ser Gln Leu Gln Glu Arg Leu Gly Pro Leu Thr Arg Asp 
        275                 280                 285             


Phe Trp Asp Asn Leu Glu Lys Glu Thr Asp Trp Val Arg Gln Glu Met 
    290                 295                 300                 


Asn Lys Asp Leu Glu Glu Val Lys Gln Lys Val Gln Pro Tyr Leu Asp 
305                 310                 315                 320 


Glu Phe Gln Lys Lys Trp Lys Glu Asp Val Glu Leu Tyr Arg Gln Lys 
                325                 330                 335     


Val Ala Pro Leu Gly Ala Glu Leu Gln Glu Ser Ala Arg Gln Lys Leu 
            340                 345                 350         


Gln Glu Leu Gln Gly Arg Leu Ser Pro Val Ala Glu Glu Phe Arg Asp 
        355                 360                 365             


Arg Met Arg Thr His Val Asp Ser Leu Arg Thr Gln Leu Ala Pro His 
    370                 375                 380                 


Ser Glu Gln Met Arg Glu Ser Leu Ala Gln Arg Leu Ala Glu Leu Lys 
385                 390                 395                 400 


Ser Asn Pro Thr Leu Asn Glu Tyr His Thr Arg Ala Lys Thr His Leu 
                405                 410                 415     


Lys Thr Leu Gly Glu Lys Ala Arg Pro Ala Leu Glu Asp Leu Arg His 
            420                 425                 430         


Ser Leu Met Pro Met Leu Glu Thr Leu Lys Thr Lys Ala Gln Ser Val 
        435                 440                 445             


Ile Asp Lys Ala Ser Glu Thr Leu Thr Ala Gln 
    450                 455                 


<210>  44
<211>  1428
<212>  DNA
<213>  Artificial

<220>
<223>  Secuencia que codifica una protena de fusin hSushi-hIL15-hApo


<220>
<221>  misc_feature
<222>  (1)..(288)
<223>  Secuencia que codifica el pptido seal y el dominio Sushi de la 
       subunidad alfa del receptor de  IL15 humano (IL15RA) (NM_002189.2
       REGION: 83 ..371)

<220>
<221>  misc_feature
<222>  (289)..(345)
<223>  Secuencia que codifica un enlazador (Linker)

<220>
<221>  misc_feature
<222>  (346)..(687)
<223>  Secuencia que codifica la IL15 humana madura (NM_172174.2 REGION:
       990 ..1331)

<220>
<221>  misc_feature
<222>  (688)..(696)
<223>  Secuencia que codifica el enlazador GAP (Linker)

<220>
<221>  misc_feature
<222>  (697)..(1425)
<223>  Secuencia que codifica la apolipoprotena A-I humana madura 
       (APOA1) (NM_000039.1 REGION: 111..839)

<400>  44
atggccccgc ggcgggcgcg cggctgccgg accctcggtc tcccggcgct gctactgctg       60

ctgctgctcc ggccgccggc gacgcggggc atcacgtgcc ctccccccat gtccgtggaa      120

cacgcagaca tctgggtcaa gagctacagc ttgtactcca gggagcggta catttgtaac      180

tctggtttca agcgtaaagc cggcacgtcc agcctgacgg agtgcgtgtt gaacaaggcc      240

acgaatgtcg cccactggac aacccccagt ctcaaatgca ttagagacgg cggctctgga      300

ggtggaggat ccggcggagg atctggcggc ggaggaagcc tgcagaactg ggtgaatgta      360

ataagtgatt tgaaaaaaat tgaagatctt attcaatcta tgcatattga tgctacttta      420

tatacggaaa gtgatgttca ccccagttgc aaagtaacag caatgaagtg ctttctcttg      480

gagttacaag ttatttcact tgagtccgga gatgcaagta ttcatgatac agtagaaaat      540

ctgatcatcc tagcaaacaa cagtttgtct tctaatggga atgtaacaga atctggatgc      600

aaagaatgtg aggaactgga ggaaaaaaat attaaagaat ttttgcagag ttttgtacat      660

attgtccaaa tgttcatcaa cacttctggc gcgcccgatg aaccccccca gagcccctgg      720

gatcgagtga aggacctggc cactgtgtac gtggatgtgc tcaaagacag cggcagagac      780

tatgtgtccc agtttgaagg ctccgccttg ggaaaacagc taaacctaaa gctccttgac      840

aactgggaca gcgtgacctc caccttcagc aagctgcgcg aacagctcgg ccctgtgacc      900

caggagttct gggataacct ggaaaaggag acagagggcc tgaggcagga gatgagcaag      960

gatctggagg aggtgaaggc caaggtgcag ccctacctgg acgacttcca gaagaagtgg     1020

caggaggaga tggagctcta ccgccagaag gtggagccgc tgcgcgcaga gctccaagag     1080

ggcgcgcgcc agaagctgca cgagctgcaa gagaagctga gcccactggg cgaggagatg     1140

cgcgaccgcg cgcgcgccca tgtggacgcg ctgcgcacgc atctggcccc ctacagcgac     1200

gagctgcgcc agcgcttggc cgcgcgcctt gaggctctca aggagaacgg cggcgccaga     1260

ctggccgagt accacgccaa ggccaccgag catctgagca cgctcagcga gaaggccaag     1320

cccgcgctcg aggacctccg ccaaggcctg ctgcccgtgc tggagagctt caaggtcagc     1380

ttcctgagcg ctctcgagga gtacactaag aagctcaaca cccagtga                  1428


<210>  45
<211>  1407
<212>  DNA
<213>  Artificial

<220>
<223>  mSushi-mIL15-mApoA1 cDNA

<400>  45
atggagacag acaccctgct gctctgggtg ctgctgctgt gggtgcccgg ctctaccggc       60

gacggcacca cctgccctcc ccctgtgtcc atcgagcacg ccgacatcag agtgaagaac      120

tactccgtga actctcggga gagatacgtg tgcaactccg gcttcaagcg gaaggccggc      180

acctccaccc tgatcgagtg cgtgatcaac aagaacacca acgtggccca ctggaccacc      240

ccttccctga agtgcatccg ggacccttcc ggcggctctg gaggtggagg atccggcgga      300

ggatctggcg gcggaggaag cctgcaggag gccaactgga tcgacgtgcg ctacgacctg      360

gagaagatcg agtccctgat ccagtccatc cacatcgaca ccaccctgta caccgactcc      420

gacttccacc cttcctgcaa ggtgaccgcc atgaactgct ttctgctgga gctgcaggtg      480

atcctgcacg agtactccaa catgaccctg aacgagacag tgcggaacgt gctgtacctg      540

gccaactcca ccctgtcctc caacaagaac gtggccgagt ccggctgcaa ggagtgcgag      600

gagctggagg agaagacctt caccgagttt ctgcagtcct tcatccggat cgtgcagatg      660

ttcatcaaca ccagcggcgc gcccgatgaa ccccagtccc aatgggacaa agtgaaggat      720

ttcgctaatg tgtatgtgga tgcggtcaaa gacagcggca gagactatgt gtcccagttt      780

gaatcctcct ccttgggcca acagctgaac ctgaatctcc tggaaaactg ggacactctg      840

ggttcaaccg ttagtcagct gcaggaacgg ctgggcccat tgactcggga cttctgggat      900

aacctggaga aagaaacaga ttgggtgaga caggagatga acaaggacct agaggaagtg      960

aaacagaagg tgcagcccta cctggacgaa ttccagaaga aatggaaaga ggatgtggag     1020

ctctaccgcc agaaggtggc gcctctgggc gccgagctgc aggagagcgc gcgccagaag     1080

ctgcaggagc tgcaagggag actgtcccct gtggctgagg aatttcgcga ccgcatgcgc     1140

acacacgtag actctctgcg cacacagcta gcgccccaca gcgaacagat gcgcgagagc     1200

ctggcccagc gcctggctga gctcaagagc aaccctacct tgaacgagta ccacaccagg     1260

gccaaaaccc acctgaagac acttggcgag aaagccagac ctgcgctgga ggacctgcgc     1320

catagtctga tgcccatgct ggagacgctt aagaccaaag cccagagtgt gatcgacaag     1380

gccagcgaga ctctgactgc ccagtga                                         1407


<210>  46
<211>  20
<212>  DNA
<213>  Artificial

<220>
<223>  Cebador FwATGmApoA1

<400>  46
atgaaagctg tggtgctggc                                                   20


<210>  47
<211>  20
<212>  DNA
<213>  Artificial

<220>
<223>  Cebador RvTGAmApoA1

<400>  47
tcactgggca gtcagagtct                                                   20


<210>  48
<211>  28
<212>  DNA
<213>  Artificial

<220>
<223>  Cebador FwAscIhIL15

<400>  48
aataatggcg cgccgaactg gatagatg                                          28


<210>  49
<211>  27
<212>  DNA
<213>  Artificial

<220>
<223>  Cebador RvNotIhIL15

<400>  49
gttcatcaac acgtcctgag cggccgc                                           27


<210>  50
<211>  28
<212>  DNA
<213>  Artificial

<220>
<223>  Cebador RvAscImApoA1

<400>  50
ggcgcgccct gggcagtcag agtctcgc                                          28


<210>  51
<211>  21
<212>  DNA
<213>  Artificial

<220>
<223>  Cebador Fw Sushi

<400>  51
atggagacag acaccctgct g                                                 21


<210>  52
<211>  27
<212>  DNA
<213>  Artificial

<220>
<223>  Cebador Rv IL15 AscI

<400>  52
gggcgcgccg ctggtgttga tgaacat                                           27


