                         SEQUENCE LISTING

<110>  Friedrich-Alexander-Universitt Erlangen-Nrnberg et al.
 
<120>  Therapeutics against acute myeloid leukaemia

<130>  R3150 PCT

<150>  EP 09 01 5260.4
<151>  2009-12-09

<160>  28    

<170>  PatentIn version 3.4

<210>  1
<211>  780
<212>  DNA
<213>  artificial sequence

<220>
<223>  /note="Description of artificial sequence: CD123 scFv Klon 43"

<400>  1
atggcggact acaaagatat tgtgatgacc cagtctcaca aattcatgtc cacatcagta     60

ggagacaggg tcaacatcac ctgcaaggcc agtcagaatg tggatagtgc tgtagcctgg    120

tatcaacaga aaccagggca atctcctaaa gcactgattt actcggcatc ctaccggtac    180

agtggagtcc ctgatcgctt cacaggcagg ggatctggga cagatttcac tctcaccatc    240

agcagtgtgc aggctgaaga cctggcagtt tattactgtc agcaatatta tagcactccg    300

tggacgttcg gtggaggcac caagctggaa atcaaacgtg gtggtggtgg ttctggtggt    360

ggtggttctg gcggcggcgg ctccggtggt ggtggatccg aggtgaagct ggtggagtct    420

ggaggaggct tggtacagcc tgggggttct ctgagtctct cctgtgcagc ttctggattc    480

accttcactg attactacat gagctgggtc cgccagcctc cagggaaggc acttgagtgg    540

ttggctttga ttagaagcaa agctgatggt tacacaacag aatacagtgc atctgtgaag    600

ggtcggttca ccctctccag agatgattcc caaagcatcc tctatcttca aatgaatgcc    660

ctgagacctg aagacagtgc cacttattac tgtgcaagag atgcggccta ctatagttac    720

tatagtcccg agggggctat ggactactgg ggtcaaggaa cctcagtcac cgtctcctcg    780


<210>  2
<211>  260
<212>  PRT
<213>  artificial sequence

<220>
<223>  /note="Description of artificial sequence: CD123 scFv Klon 43"

<400>  2

Met Ala Asp Tyr Lys Asp Ile Val Met Thr Gln Ser His Lys Phe Met 
1               5                   10                  15      


Ser Thr Ser Val Gly Asp Arg Val Asn Ile Thr Cys Lys Ala Ser Gln 
            20                  25                  30          


Asn Val Asp Ser Ala Val Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ser 
        35                  40                  45              


Pro Lys Ala Leu Ile Tyr Ser Ala Ser Tyr Arg Tyr Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Thr Gly Arg Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile 
65                  70                  75                  80  


Ser Ser Val Gln Ala Glu Asp Leu Ala Val Tyr Tyr Cys Gln Gln Tyr 
                85                  90                  95      


Tyr Ser Thr Pro Trp Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         


Arg Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
        115                 120                 125             


Gly Gly Gly Gly Ser Glu Val Lys Leu Val Glu Ser Gly Gly Gly Leu 
    130                 135                 140                 


Val Gln Pro Gly Gly Ser Leu Ser Leu Ser Cys Ala Ala Ser Gly Phe 
145                 150                 155                 160 


Thr Phe Thr Asp Tyr Tyr Met Ser Trp Val Arg Gln Pro Pro Gly Lys 
                165                 170                 175     


Ala Leu Glu Trp Leu Ala Leu Ile Arg Ser Lys Ala Asp Gly Tyr Thr 
            180                 185                 190         


Thr Glu Tyr Ser Ala Ser Val Lys Gly Arg Phe Thr Leu Ser Arg Asp 
        195                 200                 205             


Asp Ser Gln Ser Ile Leu Tyr Leu Gln Met Asn Ala Leu Arg Pro Glu 
    210                 215                 220                 


Asp Ser Ala Thr Tyr Tyr Cys Ala Arg Asp Ala Ala Tyr Tyr Ser Tyr 
225                 230                 235                 240 


Tyr Ser Pro Glu Gly Ala Met Asp Tyr Trp Gly Gln Gly Thr Ser Val 
                245                 250                 255     


Thr Val Ser Ser 
            260 


<210>  3
<211>  777
<212>  DNA
<213>  artificial sequence

<220>
<223>  /note="Description of artificial sequence: CD123 scFv Klon 19"

<400>  3
atggcggact acaaagacat tgtgatgacc caaactccac cctccctgcc tgtcagtctt     60

ggagatcaag cctccatctc ttgcagatct agtcagagcc ttgtacacag taatggaaac    120

acctatttac attggtacct gcagaagcca ggccagtctc caaagctcct gatctacaaa    180

gtttccaacc gattttctgg ggtcccagac aggttcagtg gcagtggatc agggacagat    240

ttcacactca agatcagcag agtggaggct gaggatctgg gagtttatta ctgctttcaa    300

ggttcacatg ttcctcggac gttcggtgga ggcaccaagc tggaaataaa acgtggtggt    360

ggtggttctg gtggtggtgg ttctggcggc ggcggctcca gtggtggtgg atcccaggtg    420

cagctgcagc agtctggggc tgaactggca aaacctgggg cctcagtgaa actgtcctgc    480

aaggcttctg gctacacctt tattagctac tggatacact gggtaaaaca gaggcctgga    540

cagggtctgg aatggattgg atacattaat cctagccgtg gttatactaa ctccaatcag    600

aagttcaatg acaaggccac attgactgca gacgaatcct ccagtacagc ctacatgcag    660

ctgagcagcc tgacatatga ggactctgca gtctattact gtgcaagagg ttatgattat    720

cccgggggaa tgatcattga ctactggggt caaggaacct cagtcaccgt ctcctcg       777


<210>  4
<211>  259
<212>  PRT
<213>  artificial sequence

<220>
<223>  /note="Description of artificial sequence: CD123 scFv Klon 19"

<400>  4

Met Ala Asp Tyr Lys Asp Ile Val Met Thr Gln Thr Pro Pro Ser Leu 
1               5                   10                  15      


Pro Val Ser Leu Gly Asp Gln Ala Ser Ile Ser Cys Arg Ser Ser Gln 
            20                  25                  30          


Ser Leu Val His Ser Asn Gly Asn Thr Tyr Leu His Trp Tyr Leu Gln 
        35                  40                  45              


Lys Pro Gly Gln Ser Pro Lys Leu Leu Ile Tyr Lys Val Ser Asn Arg 
    50                  55                  60                  


Phe Ser Gly Val Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp 
65                  70                  75                  80  


Phe Thr Leu Lys Ile Ser Arg Val Glu Ala Glu Asp Leu Gly Val Tyr 
                85                  90                  95      


Tyr Cys Phe Gln Gly Ser His Val Pro Arg Thr Phe Gly Gly Gly Thr 
            100                 105                 110         


Lys Leu Glu Ile Lys Arg Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
        115                 120                 125             


Gly Gly Gly Gly Ser Ser Gly Gly Gly Ser Gln Val Gln Leu Gln Gln 
    130                 135                 140                 


Ser Gly Ala Glu Leu Ala Lys Pro Gly Ala Ser Val Lys Leu Ser Cys 
145                 150                 155                 160 


Lys Ala Ser Gly Tyr Thr Phe Ile Ser Tyr Trp Ile His Trp Val Lys 
                165                 170                 175     


Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile Gly Tyr Ile Asn Pro Ser 
            180                 185                 190         


Arg Gly Tyr Thr Asn Ser Asn Gln Lys Phe Asn Asp Lys Ala Thr Leu 
        195                 200                 205             


Thr Ala Asp Glu Ser Ser Ser Thr Ala Tyr Met Gln Leu Ser Ser Leu 
    210                 215                 220                 


Thr Tyr Glu Asp Ser Ala Val Tyr Tyr Cys Ala Arg Gly Tyr Asp Tyr 
225                 230                 235                 240 


Pro Gly Gly Met Ile Ile Asp Tyr Trp Gly Gln Gly Thr Ser Val Thr 
                245                 250                 255     


Val Ser Ser 
            


<210>  5
<211>  750
<212>  DNA
<213>  artificial sequence

<220>
<223>  /note="Description of artificial sequence: CD123 scFv Klon 26"

<400>  5
atggcggact acaaagatat tgttatgacc cagtctcaca aattcatgtc cacatcagaa     60

ggagacaggg tcagtatcac ctgcaaggcc agtcagaacg tggattctgc tgtagcctgg    120

tatcaacaga aaccagggca atctcctaaa ctactgattt actgggcatc cacccggcac    180

actggagtcc ctgatcgctt cacaggcagt ggatctggga cggatttcac tctcaccatt    240

agcaatgtgc agtctgaaga cttggcagat tatttctgtc agcaatatag cagctatcca    300

ttcacgttcg gctcggggac aaagttggaa ataaaacgtg gtggtggtgg ttctggtggt    360

ggtggttccg gcggcggcgg ctccggtggt ggtggatccc aggttcaact gcagcagtct    420

ggggcagaac ttgtgaggcc aggggcctca gtcaagttgt cctgcacaac ttctggcttc    480

aacattaaag acagctatat tcactgggtg aaacagaggc ctgagcaggg cctggaatgg    540

attggaagga ttgatcctga agatggtgat actgaatatg ccccgaagtt ccagggcagg    600

gccactgtga ctgcagacac atcctccaac acagcctact tacaactcag cagcctgaca    660

tctgaggacg ctgccgtcta ttactgtgct gcaactggga cgggattctt tgacttctgg    720

ggccaaggca ccactctcac agtctcctcg                                     750


<210>  6
<211>  250
<212>  PRT
<213>  artificial sequence

<220>
<223>  /note="Description of artificial sequence: CD123 scFv Klon 26"

<400>  6

Met Ala Asp Tyr Lys Asp Ile Val Met Thr Gln Ser His Lys Phe Met 
1               5                   10                  15      


Ser Thr Ser Glu Gly Asp Arg Val Ser Ile Thr Cys Lys Ala Ser Gln 
            20                  25                  30          


Asn Val Asp Ser Ala Val Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ser 
        35                  40                  45              


Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg His Thr Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile 
65                  70                  75                  80  


Ser Asn Val Gln Ser Glu Asp Leu Ala Asp Tyr Phe Cys Gln Gln Tyr 
                85                  90                  95      


Ser Ser Tyr Pro Phe Thr Phe Gly Ser Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         


Arg Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
        115                 120                 125             


Gly Gly Gly Gly Ser Gln Val Gln Leu Gln Gln Ser Gly Ala Glu Leu 
    130                 135                 140                 


Val Arg Pro Gly Ala Ser Val Lys Leu Ser Cys Thr Thr Ser Gly Phe 
145                 150                 155                 160 


Asn Ile Lys Asp Ser Tyr Ile His Trp Val Lys Gln Arg Pro Glu Gln 
                165                 170                 175     


Gly Leu Glu Trp Ile Gly Arg Ile Asp Pro Glu Asp Gly Asp Thr Glu 
            180                 185                 190         


Tyr Ala Pro Lys Phe Gln Gly Arg Ala Thr Val Thr Ala Asp Thr Ser 
        195                 200                 205             


Ser Asn Thr Ala Tyr Leu Gln Leu Ser Ser Leu Thr Ser Glu Asp Ala 
    210                 215                 220                 


Ala Val Tyr Tyr Cys Ala Ala Thr Gly Thr Gly Phe Phe Asp Phe Trp 
225                 230                 235                 240 


Gly Gln Gly Thr Thr Leu Thr Val Ser Ser 
                245                 250 


<210>  7
<211>  780
<212>  DNA
<213>  artificial sequence

<220>
<223>  /note="Description of artificial sequence: CD123 scFv Klon 48"

<400>  7
atggcggact acaaagatat tgtgatgacc cagtctcaaa aattcatgtc cacatcagta     60

ggagacaggg tcagcatcac ctgcaaggcc agtcaggatg tgggtactgc tgtagcctgg    120

tatcaacaga aaccagggca gtctcctaaa gcactgattt acttggcatc caaccggctc    180

actggagtcc cagatcgctt cacaggcagt ggatctggga cagatttcac tctcaccatc    240

agcaatgtgc agtctgaaga cttggcagat tatttctgcc agcaatatgg cagctatccg    300

ctcacgttcg gtgctgggac caagctggaa atcaaacgtg gtggtggtgg ttctggtggt    360

ggtggttctg gcggcggcgg ctccggtggt ggtggatccg aggtgcaact ggtggagtct    420

ggaggaggct tggtacagcc tgggggttct ctgagtctct cctgtgcagc ttctggattc    480

accttcactg attactacat gagctgggtc cgccagcctc cagggaaggc acttgagtgg    540

ttggctttga ttagaagcaa agctgatggt tacacaacag aatacagtgc atctgtgaag    600

ggtcggttca ccctctccag agatgattcc caaagcatcc tctatcttca aatgaatgcc    660

ctgagacctg aagacagtgc cacttattac tgtgcaagag atgcggccta ctatagttac    720

tatagtcccg agggggctat ggactactgg ggtcaaggaa tctcagtcac cgtctcctcg    780


<210>  8
<211>  260
<212>  PRT
<213>  artificial sequence

<220>
<223>  /note="Description of artificial sequence: CD123 scFv Klon 48"

<400>  8

Met Ala Asp Tyr Lys Asp Ile Val Met Thr Gln Ser Gln Lys Phe Met 
1               5                   10                  15      


Ser Thr Ser Val Gly Asp Arg Val Ser Ile Thr Cys Lys Ala Ser Gln 
            20                  25                  30          


Asp Val Gly Thr Ala Val Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ser 
        35                  40                  45              


Pro Lys Ala Leu Ile Tyr Leu Ala Ser Asn Arg Leu Thr Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile 
65                  70                  75                  80  


Ser Asn Val Gln Ser Glu Asp Leu Ala Asp Tyr Phe Cys Gln Gln Tyr 
                85                  90                  95      


Gly Ser Tyr Pro Leu Thr Phe Gly Ala Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         


Arg Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
        115                 120                 125             


Gly Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu 
    130                 135                 140                 


Val Gln Pro Gly Gly Ser Leu Ser Leu Ser Cys Ala Ala Ser Gly Phe 
145                 150                 155                 160 


Thr Phe Thr Asp Tyr Tyr Met Ser Trp Val Arg Gln Pro Pro Gly Lys 
                165                 170                 175     


Ala Leu Glu Trp Leu Ala Leu Ile Arg Ser Lys Ala Asp Gly Tyr Thr 
            180                 185                 190         


Thr Glu Tyr Ser Ala Ser Val Lys Gly Arg Phe Thr Leu Ser Arg Asp 
        195                 200                 205             


Asp Ser Gln Ser Ile Leu Tyr Leu Gln Met Asn Ala Leu Arg Pro Glu 
    210                 215                 220                 


Asp Ser Ala Thr Tyr Tyr Cys Ala Arg Asp Ala Ala Tyr Tyr Ser Tyr 
225                 230                 235                 240 


Tyr Ser Pro Glu Gly Ala Met Asp Tyr Trp Gly Gln Gly Ile Ser Val 
                245                 250                 255     


Thr Val Ser Ser 
            260 


<210>  9
<211>  750
<212>  DNA
<213>  artificial sequence

<220>
<223>  /note="Description of artificial sequence: CD123 scFv Klon 52"

<400>  9
atggcggact acaaagatat tgtgatgaca cagactacat cctccctgtc tgcctctctg     60

ggagacagag tcaccatcag ttgcagggca agtcaggaca ttagcaatta tttaaactgg    120

tatcagcaga aaccaggaca gccacccaaa ctcctcatct atcttgcatc caacctagaa    180

tctggggtcc ctgccaggtt cagtggcagt gggtctagga cagacttcac cctcaccatt    240

gatcctgtgg aggctgatga tgctgcaacc tattactgtc agcaaaataa tgaggatcct    300

ctcacgttcg gtgctgggac caagctggag ctgaaacgtg gcggcggcgg ctccggtggt    360

ggtggatccg aggtgaagct gatggagtct ggaggaggct tggtacagcc tgggggttct    420

ctgagtctct cctgtgcagc ttctggattc accttcactg attactacat gagctgggtc    480

cgccagcctc cagggaaggc acttgagtgg ttggctttga ttagaagcaa agctgatggt    540

tacacaacag aatacagtgc atctgtgaag ggtcggttca ccctctccag agatgattcc    600

caaagcatcc tctatcttca aatgaatgcc ctgagacctg aagacagtgc cacttattac    660

tgtgcaagag atgcggccta ctatagttac tatagtcccg agggggctat ggactactgg    720

ggtcaaggaa cctcagtcac cgtctcctcg                                     750


<210>  10
<211>  250
<212>  PRT
<213>  artificial sequence

<220>
<223>  /note="Description of artificial sequence: CD123 scFv Klon 52"

<400>  10

Met Ala Asp Tyr Lys Asp Ile Val Met Thr Gln Thr Thr Ser Ser Leu 
1               5                   10                  15      


Ser Ala Ser Leu Gly Asp Arg Val Thr Ile Ser Cys Arg Ala Ser Gln 
            20                  25                  30          


Asp Ile Ser Asn Tyr Leu Asn Trp Tyr Gln Gln Lys Pro Gly Gln Pro 
        35                  40                  45              


Pro Lys Leu Leu Ile Tyr Leu Ala Ser Asn Leu Glu Ser Gly Val Pro 
    50                  55                  60                  


Ala Arg Phe Ser Gly Ser Gly Ser Arg Thr Asp Phe Thr Leu Thr Ile 
65                  70                  75                  80  


Asp Pro Val Glu Ala Asp Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Asn 
                85                  90                  95      


Asn Glu Asp Pro Leu Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys 
            100                 105                 110         


Arg Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val Lys Leu Met 
        115                 120                 125             


Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Ser Leu Ser 
    130                 135                 140                 


Cys Ala Ala Ser Gly Phe Thr Phe Thr Asp Tyr Tyr Met Ser Trp Val 
145                 150                 155                 160 


Arg Gln Pro Pro Gly Lys Ala Leu Glu Trp Leu Ala Leu Ile Arg Ser 
                165                 170                 175     


Lys Ala Asp Gly Tyr Thr Thr Glu Tyr Ser Ala Ser Val Lys Gly Arg 
            180                 185                 190         


Phe Thr Leu Ser Arg Asp Asp Ser Gln Ser Ile Leu Tyr Leu Gln Met 
        195                 200                 205             


Asn Ala Leu Arg Pro Glu Asp Ser Ala Thr Tyr Tyr Cys Ala Arg Asp 
    210                 215                 220                 


Ala Ala Tyr Tyr Ser Tyr Tyr Ser Pro Glu Gly Ala Met Asp Tyr Trp 
225                 230                 235                 240 


Gly Gln Gly Thr Ser Val Thr Val Ser Ser 
                245                 250 


<210>  11
<211>  753
<212>  DNA
<213>  artificial sequence

<220>
<223>  /note="Description of artificial sequence: CD123 scFv Klon 42"

<400>  11
atggcggact acaaagacat tgtgatgaca cagtctcaca aattcatgtc cacatcagta     60

ggagacaggg tcagcatcac ctgcaaggcc agtcaggatg tgagtactgc tgttgcctgg    120

tatcaacaga aaccagggca atctcctaaa ctactgattt actgggcatc cacccggcac    180

actggagtcc ctgatcgctt cacaggcagt ggatctggga cagatttcac tctcaccatt    240

agcaatgtgc agtctgaaga cttggcagat tatttctgtc agcaatatag cagctatccg    300

tggacgttcg gtggaggcac caagctggaa ataaaacgcg gtggtggtgg ttctggtggt    360

ggtggttctg gcggcggcgg ctccggtggt ggtggatccg aggtgcagct acttgagtct    420

gggggaacct tagtggaccc tggagggtcc ctgaaactct cctgtgcagc ctctggattc    480

actttcaata actatcccat gtcttgggtt cgccagggtc cggaaaagag gctggagtgg    540

gtcgccacca ttagttatgg tggtaattac accttctatc cagacaatct aaagggccga    600

ttcaccatct ccagagacaa tgccaagaac aacctgtatc tgcaaatgag tcatctgaag    660

tctgcggaca cagccatata ttactgtgcc agacattttg attacgactt ctttgacttc    720

tggggccaag gcaccactgt caccgtctcc tcg                                 753


<210>  12
<211>  251
<212>  PRT
<213>  artificial sequence

<220>
<223>  /note="Description of artificial sequence: CD123 scFv Klon 42"

<400>  12

Met Ala Asp Tyr Lys Asp Ile Val Met Thr Gln Ser His Lys Phe Met 
1               5                   10                  15      


Ser Thr Ser Val Gly Asp Arg Val Ser Ile Thr Cys Lys Ala Ser Gln 
            20                  25                  30          


Asp Val Ser Thr Ala Val Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ser 
        35                  40                  45              


Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg His Thr Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile 
65                  70                  75                  80  


Ser Asn Val Gln Ser Glu Asp Leu Ala Asp Tyr Phe Cys Gln Gln Tyr 
                85                  90                  95      


Ser Ser Tyr Pro Trp Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         


Arg Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
        115                 120                 125             


Gly Gly Gly Gly Ser Glu Val Gln Leu Leu Glu Ser Gly Gly Thr Leu 
    130                 135                 140                 


Val Asp Pro Gly Gly Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe 
145                 150                 155                 160 


Thr Phe Asn Asn Tyr Pro Met Ser Trp Val Arg Gln Gly Pro Glu Lys 
                165                 170                 175     


Arg Leu Glu Trp Val Ala Thr Ile Ser Tyr Gly Gly Asn Tyr Thr Phe 
            180                 185                 190         


Tyr Pro Asp Asn Leu Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala 
        195                 200                 205             


Lys Asn Asn Leu Tyr Leu Gln Met Ser His Leu Lys Ser Ala Asp Thr 
    210                 215                 220                 


Ala Ile Tyr Tyr Cys Ala Arg His Phe Asp Tyr Asp Phe Phe Asp Phe 
225                 230                 235                 240 


Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 
                245                 250     


<210>  13
<211>  765
<212>  DNA
<213>  artificial sequence

<220>
<223>  /note="Description of artificial sequence: CD123 scFv Klon 45"

<400>  13
atggcggact acaaagacat ccagatgaca cagtctcctg cttccttagc tgtatctctg     60

gggcagaggg ccaccatctc atgcagggcc agcaaaagtg tcagtacatc tggctatagt    120

tatatgcact ggtaccaaca gaaaccagga cagccaccca aactcctcat ctatcttgca    180

tccaacctag aatctggggt ccctgccagg ttcagtggca gtgggtctgg gacagacttc    240

accctcaaca tccatcctgt ggaggaggag gatgctgcaa cctattactg tcagcacagt    300

agggagcttc cgtacacgtt cggagggggg accaagctgg aaatcaaacg cggtggtggt    360

ggttctggtg gtggtggttc tggcggcggc ggctccggtg gtggtggatc cgaggtgcag    420

ctggtggagt ctgggggaac cttagtgaag cctggagggt ccctgaaact ctcctgtgca    480

gcctctggat tcactttcaa taactatccc atgtcttggg ttcgccaggg tccggaaaag    540

aggctggagt gggtcgccac cattagttat ggtggtaatt acaccttcta tccagacaat    600

ctaaagggcc gattcaccat ctccagagac aatgccaaga acaacctgta cctgcaaatg    660

agccatctga agtctgcgga cacagccata tattactgtg ccagacattt tgattacgac    720

ttctttgact tctggggcac agggaccact ctcacagtct cctcg                    765


<210>  14
<211>  255
<212>  PRT
<213>  artificial sequence

<220>
<223>  /note="Description of artificial sequence: CD123 scFv Klon 45"

<400>  14

Met Ala Asp Tyr Lys Asp Ile Gln Met Thr Gln Ser Pro Ala Ser Leu 
1               5                   10                  15      


Ala Val Ser Leu Gly Gln Arg Ala Thr Ile Ser Cys Arg Ala Ser Lys 
            20                  25                  30          


Ser Val Ser Thr Ser Gly Tyr Ser Tyr Met His Trp Tyr Gln Gln Lys 
        35                  40                  45              


Pro Gly Gln Pro Pro Lys Leu Leu Ile Tyr Leu Ala Ser Asn Leu Glu 
    50                  55                  60                  


Ser Gly Val Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe 
65                  70                  75                  80  


Thr Leu Asn Ile His Pro Val Glu Glu Glu Asp Ala Ala Thr Tyr Tyr 
                85                  90                  95      


Cys Gln His Ser Arg Glu Leu Pro Tyr Thr Phe Gly Gly Gly Thr Lys 
            100                 105                 110         


Leu Glu Ile Lys Arg Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
        115                 120                 125             


Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser 
    130                 135                 140                 


Gly Gly Thr Leu Val Lys Pro Gly Gly Ser Leu Lys Leu Ser Cys Ala 
145                 150                 155                 160 


Ala Ser Gly Phe Thr Phe Asn Asn Tyr Pro Met Ser Trp Val Arg Gln 
                165                 170                 175     


Gly Pro Glu Lys Arg Leu Glu Trp Val Ala Thr Ile Ser Tyr Gly Gly 
            180                 185                 190         


Asn Tyr Thr Phe Tyr Pro Asp Asn Leu Lys Gly Arg Phe Thr Ile Ser 
        195                 200                 205             


Arg Asp Asn Ala Lys Asn Asn Leu Tyr Leu Gln Met Ser His Leu Lys 
    210                 215                 220                 


Ser Ala Asp Thr Ala Ile Tyr Tyr Cys Ala Arg His Phe Asp Tyr Asp 
225                 230                 235                 240 


Phe Phe Asp Phe Trp Gly Thr Gly Thr Thr Leu Thr Val Ser Ser 
                245                 250                 255 


<210>  15
<211>  753
<212>  DNA
<213>  artificial sequence

<220>
<223>  /note="Description of artificial sequence: CD123 scFv Klon 54"

<400>  15
atggcggact acaaagacat tgtgatgaca cagtctcaca aattcatgtc cacatcagta     60

ggagacaggg tcagcatcac ctgcaaggcc agtcaggatg tgagtactgc tgtagcctgg    120

tatcaacaga aaccaggaca atctcctaaa ctactgattt actcggcatc ctaccggtac    180

actggagtcc ctgatcgctt cactggcagt ggatctggga cggatttcac tttcaccatc    240

agcagtgtgc aggctgaaga cctggcagtt tattactgtc agcaacatta tagtactccg    300

tacacgttcg gaggggggac caagctggaa ataaaacgcg gtggtggtgg ttctggtggt    360

ggtggttctg gcggcggcgg ctccggtggt ggtggatccg aggtgcagct agttgagtct    420

gggggaacct tagtgaagcc tggagggtcc ctgaaactct cctgtgcagc ctctggattc    480

actttcaata actatcccat gtcttgggtt cgccagggtc cggaaaagag gctggagtgg    540

gtcgccacca ttagttatgg tggtaattac accttctatc cagacaatct aaagggccga    600

ttcaccatct ccagagacaa tgccaagaac aacctgtacc tgcaaatgag ccatctgaag    660

tctgcggaca cagccatata ttactgtgcc agacattttg attacgactt ctttgacttc    720

tggggccaag gcaccagtct cacagtctcc tcg                                 753


<210>  16
<211>  251
<212>  PRT
<213>  artificial sequence

<220>
<223>  /note="Description of artificial sequence: CD123 scFv Klon 54"

<400>  16

Met Ala Asp Tyr Lys Asp Ile Val Met Thr Gln Ser His Lys Phe Met 
1               5                   10                  15      


Ser Thr Ser Val Gly Asp Arg Val Ser Ile Thr Cys Lys Ala Ser Gln 
            20                  25                  30          


Asp Val Ser Thr Ala Val Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ser 
        35                  40                  45              


Pro Lys Leu Leu Ile Tyr Ser Ala Ser Tyr Arg Tyr Thr Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp Phe Thr Phe Thr Ile 
65                  70                  75                  80  


Ser Ser Val Gln Ala Glu Asp Leu Ala Val Tyr Tyr Cys Gln Gln His 
                85                  90                  95      


Tyr Ser Thr Pro Tyr Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         


Arg Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
        115                 120                 125             


Gly Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly Thr Leu 
    130                 135                 140                 


Val Lys Pro Gly Gly Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe 
145                 150                 155                 160 


Thr Phe Asn Asn Tyr Pro Met Ser Trp Val Arg Gln Gly Pro Glu Lys 
                165                 170                 175     


Arg Leu Glu Trp Val Ala Thr Ile Ser Tyr Gly Gly Asn Tyr Thr Phe 
            180                 185                 190         


Tyr Pro Asp Asn Leu Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala 
        195                 200                 205             


Lys Asn Asn Leu Tyr Leu Gln Met Ser His Leu Lys Ser Ala Asp Thr 
    210                 215                 220                 


Ala Ile Tyr Tyr Cys Ala Arg His Phe Asp Tyr Asp Phe Phe Asp Phe 
225                 230                 235                 240 


Trp Gly Gln Gly Thr Ser Leu Thr Val Ser Ser 
                245                 250     


<210>  17
<211>  780
<212>  DNA
<213>  artificial sequence

<220>
<223>  /note="Description of artificial sequence: CD123 scFv Klon 60"

<400>  17
atggcggact acaaagacat tctgatgacc cagtctcaaa aattcatgtc cacatcagta     60

ggagacaggg tcagcgtcac ctgcaaggcc agtcagaatg tgggtactaa tgtagcctgg    120

tatcaacaga aaccagggca atctcctaaa gcactgattt actcggcatt tgaccggtac    180

agtggagtcc ctgatcgctt cacaggcagt ggatctggga cagatttcac tctcaccatc    240

agcaatgtgc agtctgaaga cttggcagag tatttctgtc agcaatataa cagctatcct    300

ctgacgttcg gtggaggcac caagctggaa ataaaacgcg gtggtggtgg ttctggtggt    360

ggtggttctg gcggcggcgg ctccggtggt ggtggatccc aggtgcagct tgtagagact    420

ggaggaggct tggtacagcc tgggggttct ctgagtctct cctgtgcagc ttctggattc    480

accttcactg attactacat gagctgggtc cgccagcctc cagggaaggc acttgagtgg    540

ttggctttga ttagaagcaa agctgatggt tacacaacag aatacagtgc atctgtgaag    600

ggtcggttca ccctctccag agatgattcc caaagcatcc tctatcttca aatgaatgcc    660

ctgagacctg aagacagtgc cacttattac tgtgcaagag atgcggccta ctatagttac    720

tatagtcccg agggggctat ggactactgg ggtcaaggaa cctcagtcac cgtctcctcg    780


<210>  18
<211>  260
<212>  PRT
<213>  artificial sequence

<220>
<223>  /note="Description of artificial sequence: CD123 scFv Klon 60"

<400>  18

Met Ala Asp Tyr Lys Asp Ile Leu Met Thr Gln Ser Gln Lys Phe Met 
1               5                   10                  15      


Ser Thr Ser Val Gly Asp Arg Val Ser Val Thr Cys Lys Ala Ser Gln 
            20                  25                  30          


Asn Val Gly Thr Asn Val Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ser 
        35                  40                  45              


Pro Lys Ala Leu Ile Tyr Ser Ala Phe Asp Arg Tyr Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile 
65                  70                  75                  80  


Ser Asn Val Gln Ser Glu Asp Leu Ala Glu Tyr Phe Cys Gln Gln Tyr 
                85                  90                  95      


Asn Ser Tyr Pro Leu Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         


Arg Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
        115                 120                 125             


Gly Gly Gly Gly Ser Gln Val Gln Leu Val Glu Thr Gly Gly Gly Leu 
    130                 135                 140                 


Val Gln Pro Gly Gly Ser Leu Ser Leu Ser Cys Ala Ala Ser Gly Phe 
145                 150                 155                 160 


Thr Phe Thr Asp Tyr Tyr Met Ser Trp Val Arg Gln Pro Pro Gly Lys 
                165                 170                 175     


Ala Leu Glu Trp Leu Ala Leu Ile Arg Ser Lys Ala Asp Gly Tyr Thr 
            180                 185                 190         


Thr Glu Tyr Ser Ala Ser Val Lys Gly Arg Phe Thr Leu Ser Arg Asp 
        195                 200                 205             


Asp Ser Gln Ser Ile Leu Tyr Leu Gln Met Asn Ala Leu Arg Pro Glu 
    210                 215                 220                 


Asp Ser Ala Thr Tyr Tyr Cys Ala Arg Asp Ala Ala Tyr Tyr Ser Tyr 
225                 230                 235                 240 


Tyr Ser Pro Glu Gly Ala Met Asp Tyr Trp Gly Gln Gly Thr Ser Val 
                245                 250                 255     


Thr Val Ser Ser 
            260 


<210>  19
<211>  771
<212>  DNA
<213>  artificial sequence

<220>
<223>  /note="Description of artificial sequence: CD123 scFv Klon 74"

<400>  19
atggcggact acaaagatgt ccagatgacc cagtctccat cctccctagc tgtgtcagtt     60

ggagagaagg ttactatgag ctgcaagtcc agtcagagcc ttttctttag tagcaatcaa    120

aagaactact tggcctggta ccagcagaaa ccagggcagt ctcctaaact gctgatttcc    180

tgggcatcca ctagggaatc tggggtccct gatcgcttca caggcagtgg atctgggaca    240

gatttcactc tcaccatcag cagtgtgaag gctgaagacc tggcagttta ttactgtcag    300

caattttata gctttcctcg gacgttcggt ggaggcacca agctggaaat aaaacgcggt    360

ggtggtggtt ctggtggtgg tggttctggc ggcggcggct ccggtggtgg tggatccgaa    420

gtgaagctgg tggagtctgg gggaggctta gtgaagcctg gagggtccct gaaactctcc    480

tgtgcagcct ctggattcac tttcagtagc tatgccatgt cttgggttcg ccagactccg    540

gaaaagaggc tggagtgggt cgcaaccgtt agttatggtg gtagttacac cttctatcca    600

gacaatgtaa agggccgatt caccatctcc agagacaatg ccaagaacaa cctgtacctg    660

caaatgagcc atctgaagtc tgaggacaca gccatgtatt attgtgcaag agattatgat    720

tacgacttct ttgactcctg gggccaaggc accactctca cagtctcctc g             771


<210>  20
<211>  257
<212>  PRT
<213>  artificial sequence

<220>
<223>  /note="Description of artificial sequence: CD123 scFv Klon 74"

<400>  20

Met Ala Asp Tyr Lys Asp Val Gln Met Thr Gln Ser Pro Ser Ser Leu 
1               5                   10                  15      


Ala Val Ser Val Gly Glu Lys Val Thr Met Ser Cys Lys Ser Ser Gln 
            20                  25                  30          


Ser Leu Phe Phe Ser Ser Asn Gln Lys Asn Tyr Leu Ala Trp Tyr Gln 
        35                  40                  45              


Gln Lys Pro Gly Gln Ser Pro Lys Leu Leu Ile Ser Trp Ala Ser Thr 
    50                  55                  60                  


Arg Glu Ser Gly Val Pro Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr 
65                  70                  75                  80  


Asp Phe Thr Leu Thr Ile Ser Ser Val Lys Ala Glu Asp Leu Ala Val 
                85                  90                  95      


Tyr Tyr Cys Gln Gln Phe Tyr Ser Phe Pro Arg Thr Phe Gly Gly Gly 
            100                 105                 110         


Thr Lys Leu Glu Ile Lys Arg Gly Gly Gly Gly Ser Gly Gly Gly Gly 
        115                 120                 125             


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val Lys Leu Val 
    130                 135                 140                 


Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly Ser Leu Lys Leu Ser 
145                 150                 155                 160 


Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr Ala Met Ser Trp Val 
                165                 170                 175     


Arg Gln Thr Pro Glu Lys Arg Leu Glu Trp Val Ala Thr Val Ser Tyr 
            180                 185                 190         


Gly Gly Ser Tyr Thr Phe Tyr Pro Asp Asn Val Lys Gly Arg Phe Thr 
        195                 200                 205             


Ile Ser Arg Asp Asn Ala Lys Asn Asn Leu Tyr Leu Gln Met Ser His 
    210                 215                 220                 


Leu Lys Ser Glu Asp Thr Ala Met Tyr Tyr Cys Ala Arg Asp Tyr Asp 
225                 230                 235                 240 


Tyr Asp Phe Phe Asp Ser Trp Gly Gln Gly Thr Thr Leu Thr Val Ser 
                245                 250                 255     


Ser 
    


<210>  21
<211>  753
<212>  DNA
<213>  artificial sequence

<220>
<223>  /note="Description of artificial sequence: CD123 scFv Klon 101"

<400>  21
atggcggact acaaagacat tgtgatgaca cagtctcaca aattcatgtc cacatcagta     60

ggagacaggg tcatcatcac ctgcaaggcc agtcaggatg tgggttctgc tgtagcctgg    120

tatcaacaga aaccaggaca atctcctaaa ctactgattt actgggcatc cacccggcac    180

actggagtcc ctgatcgctt cacaggcagt ggatctggga cagatttcac tctcaccatt    240

agcaatgtgc agtctgaaga cttggcagat tatttctgtc agcaatatag cagctatcct    300

cggacgttcg gtggaggcac caagctggaa atcaaacgcg gtggtggtgg ttctggtggt    360

ggtggttctg gcggcggcgg ctccggtggt ggtggatccg aggtgcagct agttgagtct    420

gggggaggct tagtgaagcc tggagggtcc ctgaaactct cctgtgcagc ctctggattc    480

actttcagta gctatgccat gtcttgggtt cgccagactc cggaaaagag gctggagtgg    540

gtcgcaaccg ttagttatgg tggtagttac accttctatc cagacaatgt aaagggccga    600

ttcaccatct ccagagacaa tgccaagaac aacctgtacc tgcaaatgag ccatctgaag    660

tctgaggaca cagccatgta ttattgtgca agagattatg attacgactt ctttgactcc    720

tggggccaag gcaccacggt caccgtctcc tcg                                 753


<210>  22
<211>  251
<212>  PRT
<213>  artificial sequence

<220>
<223>  /note="Description of artificial sequence: CD123 scFv Klon 101"

<400>  22

Met Ala Asp Tyr Lys Asp Ile Val Met Thr Gln Ser His Lys Phe Met 
1               5                   10                  15      


Ser Thr Ser Val Gly Asp Arg Val Ile Ile Thr Cys Lys Ala Ser Gln 
            20                  25                  30          


Asp Val Gly Ser Ala Val Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ser 
        35                  40                  45              


Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg His Thr Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile 
65                  70                  75                  80  


Ser Asn Val Gln Ser Glu Asp Leu Ala Asp Tyr Phe Cys Gln Gln Tyr 
                85                  90                  95      


Ser Ser Tyr Pro Arg Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         


Arg Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
        115                 120                 125             


Gly Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu 
    130                 135                 140                 


Val Lys Pro Gly Gly Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe 
145                 150                 155                 160 


Thr Phe Ser Ser Tyr Ala Met Ser Trp Val Arg Gln Thr Pro Glu Lys 
                165                 170                 175     


Arg Leu Glu Trp Val Ala Thr Val Ser Tyr Gly Gly Ser Tyr Thr Phe 
            180                 185                 190         


Tyr Pro Asp Asn Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala 
        195                 200                 205             


Lys Asn Asn Leu Tyr Leu Gln Met Ser His Leu Lys Ser Glu Asp Thr 
    210                 215                 220                 


Ala Met Tyr Tyr Cys Ala Arg Asp Tyr Asp Tyr Asp Phe Phe Asp Ser 
225                 230                 235                 240 


Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 
                245                 250     


<210>  23
<211>  771
<212>  DNA
<213>  artificial sequence

<220>
<223>  /note="Description of artificial sequence: CD123 scFv Klon 120"

<400>  23
atggcggact acaaagacat tgtgatgaca cagtctccat cctccctagc tgtgtcagtt     60

ggagagaagg ttactatgag ctgcaagtcc agtcagagcc ttttatttag tagtaatcaa    120

aagaactatt tggcctggta tcaacagaaa ccagggcagt ctcctaaact gctgatttac    180

tgggcatcca ctagggaatc tggggtccct gatcgcttca caggcagtgg atctgggaca    240

gatttcactc tcaccatcag cagtgtgaag gctgaagacc tggcagttta ttactgtcag    300

caattttata gctttcctcg gacgttcggt ggaggcacca agctggaaat aaaacgcggt    360

ggtggtggtt ctggtggtgg tggttctggc ggcggcggct ccggtggtgg tggatccgag    420

gtgcagctag ttgagtctgg gggaggctta gtgaagcctg gagggtccct gaaactctcc    480

tgtgcagcct ctggattcac tttcagtagc tatgccatgt cttgggttcg ccagactccg    540

gaaaagaggc tggagtgggt cgcaaccgtt agttatggtg gtagttacac cttctatcca    600

gacaatgtaa agggccgatt caccatctcc agagacaatg ccaagaacaa cctgtacctg    660

caaatgagcc atctgaagtc tgaggacaca gccatgtatt attgtgcaag agattatgat    720

tacgacttct ttgactcctg gggccaaggc accacggtca cagtctcctc g             771


<210>  24
<211>  257
<212>  PRT
<213>  artificial sequence

<220>
<223>  /note="Description of artificial sequence: CD123 scFv Klon 120"

<400>  24

Met Ala Asp Tyr Lys Asp Ile Val Met Thr Gln Ser Pro Ser Ser Leu 
1               5                   10                  15      


Ala Val Ser Val Gly Glu Lys Val Thr Met Ser Cys Lys Ser Ser Gln 
            20                  25                  30          


Ser Leu Leu Phe Ser Ser Asn Gln Lys Asn Tyr Leu Ala Trp Tyr Gln 
        35                  40                  45              


Gln Lys Pro Gly Gln Ser Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr 
    50                  55                  60                  


Arg Glu Ser Gly Val Pro Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr 
65                  70                  75                  80  


Asp Phe Thr Leu Thr Ile Ser Ser Val Lys Ala Glu Asp Leu Ala Val 
                85                  90                  95      


Tyr Tyr Cys Gln Gln Phe Tyr Ser Phe Pro Arg Thr Phe Gly Gly Gly 
            100                 105                 110         


Thr Lys Leu Glu Ile Lys Arg Gly Gly Gly Gly Ser Gly Gly Gly Gly 
        115                 120                 125             


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Val 
    130                 135                 140                 


Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly Ser Leu Lys Leu Ser 
145                 150                 155                 160 


Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr Ala Met Ser Trp Val 
                165                 170                 175     


Arg Gln Thr Pro Glu Lys Arg Leu Glu Trp Val Ala Thr Val Ser Tyr 
            180                 185                 190         


Gly Gly Ser Tyr Thr Phe Tyr Pro Asp Asn Val Lys Gly Arg Phe Thr 
        195                 200                 205             


Ile Ser Arg Asp Asn Ala Lys Asn Asn Leu Tyr Leu Gln Met Ser His 
    210                 215                 220                 


Leu Lys Ser Glu Asp Thr Ala Met Tyr Tyr Cys Ala Arg Asp Tyr Asp 
225                 230                 235                 240 


Tyr Asp Phe Phe Asp Ser Trp Gly Gln Gly Thr Thr Val Thr Val Ser 
                245                 250                 255     


Ser 
    


<210>  25
<211>  753
<212>  DNA
<213>  artificial sequence

<220>
<223>  /note="Description of artificial sequence: CD123 scFv Klon 148"

<400>  25
atggcggact acaaagatgt tgtgatgacc cagtctcaaa aattcatgtc cacatcagta     60

ggagacaggg tcagcgtcac ctgcaaggcc agtcagaatg tgggtactaa tgtagcctgg    120

tatcaacaga aaccagggca atctcctaaa gcactgattt actcggcatc ctaccggtac    180

agtggagtcc ctgatcgctt cacaggcagt ggatctggga cagatttcac tctcaccatc    240

agcaatgtgc agtctgaaga cttggcagag tatttctgtc agcaatataa cagctatccg    300

tacacgttcg gaggggggac caagctggaa atcaaacgcg gtggtggtgg ttctggtggt    360

ggtggttctg gcggcggcgg ctccggtggt ggtggatccg aggtgcagct agttgagtct    420

gggggaacct tagtgaagcc tggagggtcc ctgaaactct cctgtgcagc ctctggattc    480

actttcaata actatcccat gtcttgggtt cgccagggtc cggaaaagag gctggagtgg    540

gtcgccacca ttagttatgg tggtaattac accttctatc cagacaatct aaagggccga    600

ttcaccatct ccagagacaa tgccaagaac aacctgtacc tgcaaatgag ccatctgaag    660

tctgcggaca cagccatata ttactgtgcc agacattttg attacgactt ctttgacttc    720

tggggccaag gcaccactct cacagtctcc tcg                                 753


<210>  26
<211>  251
<212>  PRT
<213>  artificial sequence

<220>
<223>  /note="Description of artificial sequence: CD123 scFv Klon 148"

<400>  26

Met Ala Asp Tyr Lys Asp Val Val Met Thr Gln Ser Gln Lys Phe Met 
1               5                   10                  15      


Ser Thr Ser Val Gly Asp Arg Val Ser Val Thr Cys Lys Ala Ser Gln 
            20                  25                  30          


Asn Val Gly Thr Asn Val Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ser 
        35                  40                  45              


Pro Lys Ala Leu Ile Tyr Ser Ala Ser Tyr Arg Tyr Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile 
65                  70                  75                  80  


Ser Asn Val Gln Ser Glu Asp Leu Ala Glu Tyr Phe Cys Gln Gln Tyr 
                85                  90                  95      


Asn Ser Tyr Pro Tyr Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         


Arg Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
        115                 120                 125             


Gly Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly Thr Leu 
    130                 135                 140                 


Val Lys Pro Gly Gly Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe 
145                 150                 155                 160 


Thr Phe Asn Asn Tyr Pro Met Ser Trp Val Arg Gln Gly Pro Glu Lys 
                165                 170                 175     


Arg Leu Glu Trp Val Ala Thr Ile Ser Tyr Gly Gly Asn Tyr Thr Phe 
            180                 185                 190         


Tyr Pro Asp Asn Leu Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala 
        195                 200                 205             


Lys Asn Asn Leu Tyr Leu Gln Met Ser His Leu Lys Ser Ala Asp Thr 
    210                 215                 220                 


Ala Ile Tyr Tyr Cys Ala Arg His Phe Asp Tyr Asp Phe Phe Asp Phe 
225                 230                 235                 240 


Trp Gly Gln Gly Thr Thr Leu Thr Val Ser Ser 
                245                 250     


<210>  27
<211>  2436
<212>  DNA
<213>  artificial sequence

<220>
<223>  /note="Description of artificial sequence: Sctb [123 x ds16 x 
       33]"

<400>  27
atggcggact acaaagatat tgtgatgacc cagtctcaca aattcatgtc cacatcagta     60

ggagacaggg tcaacatcac ctgcaaggcc agtcagaatg tggatagtgc tgtagcctgg    120

tatcaacaga aaccagggca atctcctaaa gcactgattt actcggcatc ctaccggtac    180

agtggagtcc ctgatcgctt cacaggcagg ggatctggga cagatttcac tctcaccatc    240

agcagtgtgc aggctgaaga cctggcagtt tattactgtc agcaatatta tagcactccg    300

tggacgttcg gtggaggcac caagctggaa atcaaacgtg gtggtggtgg ttctggtggt    360

ggtggttctg gcggcggcgg ctccggtggt ggtggatccg aggtgaagct ggtggagtct    420

ggaggaggct tggtacagcc tgggggttct ctgagtctct cctgtgcagc ttctggattc    480

accttcactg attactacat gagctgggtc cgccagcctc cagggaaggc acttgagtgg    540

ttggctttga ttagaagcaa agctgatggt tacacaacag aatacagtgc atctgtgaag    600

ggtcggttca ccctctccag agatgattcc caaagcatcc tctatcttca aatgaatgcc    660

ctgagacctg aagacagtgc cacttattac tgtgcaagag atgcggccta ctatagttac    720

tatagtcccg agggggctat ggactactgg ggtcaaggaa cctcagtcac cgtctcctcg    780

gcctcggggg ccggtggtgg cggcagtggt ggtggcggca gtggtggtgg cggcagtggt    840

ggtggcggca gtgcggccgc ggactacaaa gacattgtgc tgacccaatc tccagcttct    900

ttggctgtgt ctctagggca gagggccacc atctcctgca aggccagcca aagtgttgat    960

tttgatggtg atagttttat gaactggtac caacagaaac caggacagcc acccaaactc   1020

ctcatctata ctacatccaa tctagaatct gggatcccag ccaggtttag tgccagtggg   1080

tctgggacag acttcaccct caacatccat cctgtggagg aggaggatac tgcaacctat   1140

tactgtcagc aaagtaatga ggatccgtac acgttcggat gcgggaccaa gctggagctg   1200

aaacgtggtg gtggtggttc tggtggtggt ggttctggcg gcggcggctc cggtggtggt   1260

ggatcccagg ttactctgaa agagtctggc cctgggatat tgcagccctc ccagaccctc   1320

agtctgactt gttctttctc tgggttttca ctgaggactt ctggtatggg tgtaggctgg   1380

attcgtcagc cttcagggaa gtgcctagag tggctggcac acatttggtg ggatgatgac   1440

aagcgctata atccagccct gaagagccga ctgacaatct ccaaggatac ctccagcaac   1500

caggtattcc tcaaaatcgc cagtgtggac actgcagata ctgccacata ctactgtgct   1560

caaataaacc ccgcctggtt tgcttactgg ggccaaggga ctctggtcac tgtctctcga   1620

ggtggtggtg gttctggagg aggaggatct ggcggcggcg gctctggagg cggaggctct   1680

atggcggact acaaagacat tgtgatgacc cagtctcaca aattcctgct tgtatcagta   1740

ggagacaggg tcagcatcac ctgcaaggcc agtcaggatg tgagtactgc tgtagcctgg   1800

tatcaacaga aaccaggaca atctcctaaa ctactgattt actcggcatc ctaccggtac   1860

actggagtcc ctgatcgctt cataggcagt ggatctggga cagatttcac tcttaccatc   1920

agcagtgtgc aggctgaaga cctggcagat tacttctgtc agcaacatta tagcactccg   1980

ctcacgttcg gtgctgggac caagctggaa ataaaacgtg gtggtggtgg ttctggtggt   2040

ggtggttctg gcggcggcgg ctccagtggt ggtggatccg aggtgcagct gaaggagtca   2100

ggacctggcc tggtggcgcc ctcacagagc ctgtccatca catgcactgt ctcagggttc   2160

ccattaacca gctatggtgt aagctgggtt cgccagcctc caggaaaggg tctggagtgg   2220

ctgggagtaa tatggggtga cgggagcaca aattatcatt cagctctcat atccagactg   2280

agcatcagca aggataactc caagagccaa gttttcttaa aactgaacaa tctgcaaact   2340

gatgacacag ccacgtacta ctgtgcccgt gatacttact acccctacta tgctatggac   2400

tattggggtc aaggaacctc agtcaccgtc tcctcg                             2436


<210>  28
<211>  812
<212>  PRT
<213>  artificial sequence

<220>
<223>  /note="Description of artificial sequence: Sctb [123 x ds16 x 
       33]"

<400>  28

Met Ala Asp Tyr Lys Asp Ile Val Met Thr Gln Ser His Lys Phe Met 
1               5                   10                  15      


Ser Thr Ser Val Gly Asp Arg Val Asn Ile Thr Cys Lys Ala Ser Gln 
            20                  25                  30          


Asn Val Asp Ser Ala Val Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ser 
        35                  40                  45              


Pro Lys Ala Leu Ile Tyr Ser Ala Ser Tyr Arg Tyr Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Thr Gly Arg Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile 
65                  70                  75                  80  


Ser Ser Val Gln Ala Glu Asp Leu Ala Val Tyr Tyr Cys Gln Gln Tyr 
                85                  90                  95      


Tyr Ser Thr Pro Trp Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         


Arg Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
        115                 120                 125             


Gly Gly Gly Gly Ser Glu Val Lys Leu Val Glu Ser Gly Gly Gly Leu 
    130                 135                 140                 


Val Gln Pro Gly Gly Ser Leu Ser Leu Ser Cys Ala Ala Ser Gly Phe 
145                 150                 155                 160 


Thr Phe Thr Asp Tyr Tyr Met Ser Trp Val Arg Gln Pro Pro Gly Lys 
                165                 170                 175     


Ala Leu Glu Trp Leu Ala Leu Ile Arg Ser Lys Ala Asp Gly Tyr Thr 
            180                 185                 190         


Thr Glu Tyr Ser Ala Ser Val Lys Gly Arg Phe Thr Leu Ser Arg Asp 
        195                 200                 205             


Asp Ser Gln Ser Ile Leu Tyr Leu Gln Met Asn Ala Leu Arg Pro Glu 
    210                 215                 220                 


Asp Ser Ala Thr Tyr Tyr Cys Ala Arg Asp Ala Ala Tyr Tyr Ser Tyr 
225                 230                 235                 240 


Tyr Ser Pro Glu Gly Ala Met Asp Tyr Trp Gly Gln Gly Thr Ser Val 
                245                 250                 255     


Thr Val Ser Ser Ala Ser Gly Ala Gly Gly Gly Gly Ser Gly Gly Gly 
            260                 265                 270         


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala Ala Ala Asp 
        275                 280                 285             


Tyr Lys Asp Ile Val Leu Thr Gln Ser Pro Ala Ser Leu Ala Val Ser 
    290                 295                 300                 


Leu Gly Gln Arg Ala Thr Ile Ser Cys Lys Ala Ser Gln Ser Val Asp 
305                 310                 315                 320 


Phe Asp Gly Asp Ser Phe Met Asn Trp Tyr Gln Gln Lys Pro Gly Gln 
                325                 330                 335     


Pro Pro Lys Leu Leu Ile Tyr Thr Thr Ser Asn Leu Glu Ser Gly Ile 
            340                 345                 350         


Pro Ala Arg Phe Ser Ala Ser Gly Ser Gly Thr Asp Phe Thr Leu Asn 
        355                 360                 365             


Ile His Pro Val Glu Glu Glu Asp Thr Ala Thr Tyr Tyr Cys Gln Gln 
    370                 375                 380                 


Ser Asn Glu Asp Pro Tyr Thr Phe Gly Cys Gly Thr Lys Leu Glu Leu 
385                 390                 395                 400 


Lys Arg Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
                405                 410                 415     


Ser Gly Gly Gly Gly Ser Gln Val Thr Leu Lys Glu Ser Gly Pro Gly 
            420                 425                 430         


Ile Leu Gln Pro Ser Gln Thr Leu Ser Leu Thr Cys Ser Phe Ser Gly 
        435                 440                 445             


Phe Ser Leu Arg Thr Ser Gly Met Gly Val Gly Trp Ile Arg Gln Pro 
    450                 455                 460                 


Ser Gly Lys Cys Leu Glu Trp Leu Ala His Ile Trp Trp Asp Asp Asp 
465                 470                 475                 480 


Lys Arg Tyr Asn Pro Ala Leu Lys Ser Arg Leu Thr Ile Ser Lys Asp 
                485                 490                 495     


Thr Ser Ser Asn Gln Val Phe Leu Lys Ile Ala Ser Val Asp Thr Ala 
            500                 505                 510         


Asp Thr Ala Thr Tyr Tyr Cys Ala Gln Ile Asn Pro Ala Trp Phe Ala 
        515                 520                 525             


Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Arg Gly Gly Gly Gly 
    530                 535                 540                 


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
545                 550                 555                 560 


Met Ala Asp Tyr Lys Asp Ile Val Met Thr Gln Ser His Lys Phe Leu 
                565                 570                 575     


Leu Val Ser Val Gly Asp Arg Val Ser Ile Thr Cys Lys Ala Ser Gln 
            580                 585                 590         


Asp Val Ser Thr Ala Val Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ser 
        595                 600                 605             


Pro Lys Leu Leu Ile Tyr Ser Ala Ser Tyr Arg Tyr Thr Gly Val Pro 
    610                 615                 620                 


Asp Arg Phe Ile Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile 
625                 630                 635                 640 


Ser Ser Val Gln Ala Glu Asp Leu Ala Asp Tyr Phe Cys Gln Gln His 
                645                 650                 655     


Tyr Ser Thr Pro Leu Thr Phe Gly Ala Gly Thr Lys Leu Glu Ile Lys 
            660                 665                 670         


Arg Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
        675                 680                 685             


Ser Gly Gly Gly Ser Glu Val Gln Leu Lys Glu Ser Gly Pro Gly Leu 
    690                 695                 700                 


Val Ala Pro Ser Gln Ser Leu Ser Ile Thr Cys Thr Val Ser Gly Phe 
705                 710                 715                 720 


Pro Leu Thr Ser Tyr Gly Val Ser Trp Val Arg Gln Pro Pro Gly Lys 
                725                 730                 735     


Gly Leu Glu Trp Leu Gly Val Ile Trp Gly Asp Gly Ser Thr Asn Tyr 
            740                 745                 750         


His Ser Ala Leu Ile Ser Arg Leu Ser Ile Ser Lys Asp Asn Ser Lys 
        755                 760                 765             


Ser Gln Val Phe Leu Lys Leu Asn Asn Leu Gln Thr Asp Asp Thr Ala 
    770                 775                 780                 


Thr Tyr Tyr Cys Ala Arg Asp Thr Tyr Tyr Pro Tyr Tyr Ala Met Asp 
785                 790                 795                 800 


Tyr Trp Gly Gln Gly Thr Ser Val Thr Val Ser Ser 
                805                 810         


