                         SEQUENCE LISTING

<110>  Abbott GmbH & Co. KG
      
 
<120>  Antibodies against the RGM A protein for use in the treatment of 
       Retinal Nerve Fiber Layer degeneration

<130>  M/50237

<160>  68    

<170>  PatentIn version 3.3

<210>  1
<211>  1353
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (1)..(1353)

<400>  1
atg cag ccg cca agg gag agg cta gtg gta aca ggc cga gct gga tgg       48
Met Gln Pro Pro Arg Glu Arg Leu Val Val Thr Gly Arg Ala Gly Trp         
1               5                   10                  15              

atg ggt atg ggg aga ggg gca gga cgt tca gcc ctg gga ttc tgg ccg       96
Met Gly Met Gly Arg Gly Ala Gly Arg Ser Ala Leu Gly Phe Trp Pro         
            20                  25                  30                  

acc ctc gcc ttc ctt ctc tgc agc ttc ccc gca gcc acc tcc ccg tgc      144
Thr Leu Ala Phe Leu Leu Cys Ser Phe Pro Ala Ala Thr Ser Pro Cys         
        35                  40                  45                      

aag atc ctc aag tgc aac tct gag ttc tgg agc gcc acg tcg ggc agc      192
Lys Ile Leu Lys Cys Asn Ser Glu Phe Trp Ser Ala Thr Ser Gly Ser         
    50                  55                  60                          

cac gcc cca gcc tca gac gac acc ccc gag ttc tgt gca gcc ttg cgc      240
His Ala Pro Ala Ser Asp Asp Thr Pro Glu Phe Cys Ala Ala Leu Arg         
65                  70                  75                  80          

agc tac gcc ctg tgc acg cgg cgg acg gcc cgc acc tgc cgg ggt gac      288
Ser Tyr Ala Leu Cys Thr Arg Arg Thr Ala Arg Thr Cys Arg Gly Asp         
                85                  90                  95              

ctg gcc tac cac tcg gcc gtc cat ggc ata gag gac ctc atg agc cag      336
Leu Ala Tyr His Ser Ala Val His Gly Ile Glu Asp Leu Met Ser Gln         
            100                 105                 110                 

cac aac tgc tcc aag gat ggc ccc acc tcg cag cca cgc ctg cgc acg      384
His Asn Cys Ser Lys Asp Gly Pro Thr Ser Gln Pro Arg Leu Arg Thr         
        115                 120                 125                     

ctc cca ccg gcc gga gac agc cag gag cgc tcg gac agc ccc gag atc      432
Leu Pro Pro Ala Gly Asp Ser Gln Glu Arg Ser Asp Ser Pro Glu Ile         
    130                 135                 140                         

tgc cat tac gag aag agc ttt cac aag cac tcg gcc acc ccc aac tac      480
Cys His Tyr Glu Lys Ser Phe His Lys His Ser Ala Thr Pro Asn Tyr         
145                 150                 155                 160         

acg cac tgt ggc ctc ttc ggg gac cca cac ctc agg act ttc acc gac      528
Thr His Cys Gly Leu Phe Gly Asp Pro His Leu Arg Thr Phe Thr Asp         
                165                 170                 175             

cgc ttc cag acc tgc aag gtg cag ggc gcc tgg ccg ctc atc gac aat      576
Arg Phe Gln Thr Cys Lys Val Gln Gly Ala Trp Pro Leu Ile Asp Asn         
            180                 185                 190                 

aat tac ctg aac gtg cag gcc acc aac acg cct gtg ctg ccc ggc tca      624
Asn Tyr Leu Asn Val Gln Ala Thr Asn Thr Pro Val Leu Pro Gly Ser         
        195                 200                 205                     

gcg gcc act gcc acc agc aag ctc acc atc atc ttc aag aac ttc cag      672
Ala Ala Thr Ala Thr Ser Lys Leu Thr Ile Ile Phe Lys Asn Phe Gln         
    210                 215                 220                         

gag tgt gtg gac cag aag gtg tac cag gct gag atg gac gag ctc ccg      720
Glu Cys Val Asp Gln Lys Val Tyr Gln Ala Glu Met Asp Glu Leu Pro         
225                 230                 235                 240         

gcc gcc ttc gtg gat ggc tct aag aac ggt ggg gac aag cac ggg gcc      768
Ala Ala Phe Val Asp Gly Ser Lys Asn Gly Gly Asp Lys His Gly Ala         
                245                 250                 255             

aac agc ctg aag atc act gag aag gtg tca ggc cag cac gtg gag atc      816
Asn Ser Leu Lys Ile Thr Glu Lys Val Ser Gly Gln His Val Glu Ile         
            260                 265                 270                 

cag gcc aag tac atc ggc acc acc atc gtg gtg cgc cag gtg ggc cgc      864
Gln Ala Lys Tyr Ile Gly Thr Thr Ile Val Val Arg Gln Val Gly Arg         
        275                 280                 285                     

tac ctg acc ttt gcc gtc cgc atg cca gag gaa gtg gtc aat gct gtg      912
Tyr Leu Thr Phe Ala Val Arg Met Pro Glu Glu Val Val Asn Ala Val         
    290                 295                 300                         

gag gac tgg gac agc cag ggt ctc tac ctc tgc ctg cgg ggc tgc ccc      960
Glu Asp Trp Asp Ser Gln Gly Leu Tyr Leu Cys Leu Arg Gly Cys Pro         
305                 310                 315                 320         

ctc aac cag cag atc gac ttc cag gcc ttc cac acc aat gct gag ggc     1008
Leu Asn Gln Gln Ile Asp Phe Gln Ala Phe His Thr Asn Ala Glu Gly         
                325                 330                 335             

acc ggt gcc cgc agg ctg gca gcc gcc agc cct gca ccc aca gcc ccc     1056
Thr Gly Ala Arg Arg Leu Ala Ala Ala Ser Pro Ala Pro Thr Ala Pro         
            340                 345                 350                 

gag acc ttc cca tac gag aca gcc gtg gcc aag tgc aag gag aag ctg     1104
Glu Thr Phe Pro Tyr Glu Thr Ala Val Ala Lys Cys Lys Glu Lys Leu         
        355                 360                 365                     

ccg gtg gag gac ctg tac tac cag gcc tgc gtc ttc gac ctc ctc acc     1152
Pro Val Glu Asp Leu Tyr Tyr Gln Ala Cys Val Phe Asp Leu Leu Thr         
    370                 375                 380                         

acg ggc gac gtg aac ttc aca ctg gcc gcc tac tac gcg ttg gag gat     1200
Thr Gly Asp Val Asn Phe Thr Leu Ala Ala Tyr Tyr Ala Leu Glu Asp         
385                 390                 395                 400         

gtc aag atg ctc cac tcc aac aaa gac aaa ctg cac ctg tat gag agg     1248
Val Lys Met Leu His Ser Asn Lys Asp Lys Leu His Leu Tyr Glu Arg         
                405                 410                 415             

act cgg gac ctg cca ggc agg gcg gct gcg ggg ctg ccc ctg gcc ccc     1296
Thr Arg Asp Leu Pro Gly Arg Ala Ala Ala Gly Leu Pro Leu Ala Pro         
            420                 425                 430                 

cgg ccc ctc ctg ggc gcc ctc gtc ccg ctc ctg gcc ctg ctc cct gtg     1344
Arg Pro Leu Leu Gly Ala Leu Val Pro Leu Leu Ala Leu Leu Pro Val         
        435                 440                 445                     

ttc tgc tag                                                         1353
Phe Cys                                                                 
    450                                                                 


<210>  2
<211>  450
<212>  PRT
<213>  Homo sapiens

<400>  2

Met Gln Pro Pro Arg Glu Arg Leu Val Val Thr Gly Arg Ala Gly Trp 
1               5                   10                  15      


Met Gly Met Gly Arg Gly Ala Gly Arg Ser Ala Leu Gly Phe Trp Pro 
            20                  25                  30          


Thr Leu Ala Phe Leu Leu Cys Ser Phe Pro Ala Ala Thr Ser Pro Cys 
        35                  40                  45              


Lys Ile Leu Lys Cys Asn Ser Glu Phe Trp Ser Ala Thr Ser Gly Ser 
    50                  55                  60                  


His Ala Pro Ala Ser Asp Asp Thr Pro Glu Phe Cys Ala Ala Leu Arg 
65                  70                  75                  80  


Ser Tyr Ala Leu Cys Thr Arg Arg Thr Ala Arg Thr Cys Arg Gly Asp 
                85                  90                  95      


Leu Ala Tyr His Ser Ala Val His Gly Ile Glu Asp Leu Met Ser Gln 
            100                 105                 110         


His Asn Cys Ser Lys Asp Gly Pro Thr Ser Gln Pro Arg Leu Arg Thr 
        115                 120                 125             


Leu Pro Pro Ala Gly Asp Ser Gln Glu Arg Ser Asp Ser Pro Glu Ile 
    130                 135                 140                 


Cys His Tyr Glu Lys Ser Phe His Lys His Ser Ala Thr Pro Asn Tyr 
145                 150                 155                 160 


Thr His Cys Gly Leu Phe Gly Asp Pro His Leu Arg Thr Phe Thr Asp 
                165                 170                 175     


Arg Phe Gln Thr Cys Lys Val Gln Gly Ala Trp Pro Leu Ile Asp Asn 
            180                 185                 190         


Asn Tyr Leu Asn Val Gln Ala Thr Asn Thr Pro Val Leu Pro Gly Ser 
        195                 200                 205             


Ala Ala Thr Ala Thr Ser Lys Leu Thr Ile Ile Phe Lys Asn Phe Gln 
    210                 215                 220                 


Glu Cys Val Asp Gln Lys Val Tyr Gln Ala Glu Met Asp Glu Leu Pro 
225                 230                 235                 240 


Ala Ala Phe Val Asp Gly Ser Lys Asn Gly Gly Asp Lys His Gly Ala 
                245                 250                 255     


Asn Ser Leu Lys Ile Thr Glu Lys Val Ser Gly Gln His Val Glu Ile 
            260                 265                 270         


Gln Ala Lys Tyr Ile Gly Thr Thr Ile Val Val Arg Gln Val Gly Arg 
        275                 280                 285             


Tyr Leu Thr Phe Ala Val Arg Met Pro Glu Glu Val Val Asn Ala Val 
    290                 295                 300                 


Glu Asp Trp Asp Ser Gln Gly Leu Tyr Leu Cys Leu Arg Gly Cys Pro 
305                 310                 315                 320 


Leu Asn Gln Gln Ile Asp Phe Gln Ala Phe His Thr Asn Ala Glu Gly 
                325                 330                 335     


Thr Gly Ala Arg Arg Leu Ala Ala Ala Ser Pro Ala Pro Thr Ala Pro 
            340                 345                 350         


Glu Thr Phe Pro Tyr Glu Thr Ala Val Ala Lys Cys Lys Glu Lys Leu 
        355                 360                 365             


Pro Val Glu Asp Leu Tyr Tyr Gln Ala Cys Val Phe Asp Leu Leu Thr 
    370                 375                 380                 


Thr Gly Asp Val Asn Phe Thr Leu Ala Ala Tyr Tyr Ala Leu Glu Asp 
385                 390                 395                 400 


Val Lys Met Leu His Ser Asn Lys Asp Lys Leu His Leu Tyr Glu Arg 
                405                 410                 415     


Thr Arg Asp Leu Pro Gly Arg Ala Ala Ala Gly Leu Pro Leu Ala Pro 
            420                 425                 430         


Arg Pro Leu Leu Gly Ala Leu Val Pro Leu Leu Ala Leu Leu Pro Val 
        435                 440                 445             


Phe Cys 
    450 


<210>  3
<211>  1929
<212>  DNA
<213>  Artificial

<220>
<223>  hRGMA fc


<220>
<221>  CDS
<222>  (1)..(1929)

<220>
<221>  sig_peptide
<222>  (1)..(102)

<220>
<221>  misc_feature
<222>  (103)..(1230)
<223>  hRGMA Fragment 47-422

<220>
<221>  misc_feature
<222>  (1231)..(1929)
<223>  fc portion

<400>  3
atg gag aca gac aca ctc ctg cta tgg gta ctg ctg ctc tgg gtt cca       48
Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro         
1               5                   10                  15              

ggt tcc act ggt gac gcg gcc cag ccg gcc agg cgc gcg cgc cgt acg       96
Gly Ser Thr Gly Asp Ala Ala Gln Pro Ala Arg Arg Ala Arg Arg Thr         
            20                  25                  30                  

aag ctt ccg tgc aag atc ctc aag tgc aac tct gag ttc tgg agc gcc      144
Lys Leu Pro Cys Lys Ile Leu Lys Cys Asn Ser Glu Phe Trp Ser Ala         
        35                  40                  45                      

acg tcg ggc agc cac gcc cca gcc tca gac gac acc ccc gag ttc tgt      192
Thr Ser Gly Ser His Ala Pro Ala Ser Asp Asp Thr Pro Glu Phe Cys         
    50                  55                  60                          

gca gcc ttg cgc agc tac gcc ctg tgc acg cgg cgg acg gcc cgc acc      240
Ala Ala Leu Arg Ser Tyr Ala Leu Cys Thr Arg Arg Thr Ala Arg Thr         
65                  70                  75                  80          

tgc cgg ggt gac ctg gcc tac cac tcg gcc gtc cat ggc ata gag gac      288
Cys Arg Gly Asp Leu Ala Tyr His Ser Ala Val His Gly Ile Glu Asp         
                85                  90                  95              

ctc atg agc cag cac aac tgc tcc aag gat ggc ccc acc tcg cag cca      336
Leu Met Ser Gln His Asn Cys Ser Lys Asp Gly Pro Thr Ser Gln Pro         
            100                 105                 110                 

cgc ctg cgc acg ctc cca ccg gcc gga gac agc cag gag cgc tcg gac      384
Arg Leu Arg Thr Leu Pro Pro Ala Gly Asp Ser Gln Glu Arg Ser Asp         
        115                 120                 125                     

agc ccc gag atc tgc cat tac gag aag agc ttt cac aag cac tcg gcc      432
Ser Pro Glu Ile Cys His Tyr Glu Lys Ser Phe His Lys His Ser Ala         
    130                 135                 140                         

acc ccc aac tac acg cac tgt ggc ctc ttc ggg gac cca cac ctc agg      480
Thr Pro Asn Tyr Thr His Cys Gly Leu Phe Gly Asp Pro His Leu Arg         
145                 150                 155                 160         

act ttc acc gac cgc ttc cag acc tgc aag gtg cag ggc gcc tgg ccg      528
Thr Phe Thr Asp Arg Phe Gln Thr Cys Lys Val Gln Gly Ala Trp Pro         
                165                 170                 175             

ctc atc gac aat aat tac ctg aac gtg cag gtc acc aac acg cct gtg      576
Leu Ile Asp Asn Asn Tyr Leu Asn Val Gln Val Thr Asn Thr Pro Val         
            180                 185                 190                 

ctg ccc ggc tca gcg gcc act gcc acc agc aag ctc acc atc atc ttc      624
Leu Pro Gly Ser Ala Ala Thr Ala Thr Ser Lys Leu Thr Ile Ile Phe         
        195                 200                 205                     

aag aac ttc cag gag tgt gtg gac cag aag gtg tac cag gct gag atg      672
Lys Asn Phe Gln Glu Cys Val Asp Gln Lys Val Tyr Gln Ala Glu Met         
    210                 215                 220                         

gac gag ctc ccg gcc gcc ttc gtg gat ggc tct aag aac ggt ggg gac      720
Asp Glu Leu Pro Ala Ala Phe Val Asp Gly Ser Lys Asn Gly Gly Asp         
225                 230                 235                 240         

aag cac ggg gcc aac agc ctg aag atc act gag aag gtg tca ggc cag      768
Lys His Gly Ala Asn Ser Leu Lys Ile Thr Glu Lys Val Ser Gly Gln         
                245                 250                 255             

cac gtg gag atc cag gcc aag tac atc ggc acc acc atc gtg gtg cgc      816
His Val Glu Ile Gln Ala Lys Tyr Ile Gly Thr Thr Ile Val Val Arg         
            260                 265                 270                 

cag gtg ggc cgc tac ctg acc ttt gcc gtc cgc atg cca gag gaa gtg      864
Gln Val Gly Arg Tyr Leu Thr Phe Ala Val Arg Met Pro Glu Glu Val         
        275                 280                 285                     

gtc aat gct gtg gag gac tgg gac agc cag ggt ctc tac ctc tgc ctg      912
Val Asn Ala Val Glu Asp Trp Asp Ser Gln Gly Leu Tyr Leu Cys Leu         
    290                 295                 300                         

cgg ggc tgc ccc ctc aac cag cag atc gac ttc cag gcc ttc cac acc      960
Arg Gly Cys Pro Leu Asn Gln Gln Ile Asp Phe Gln Ala Phe His Thr         
305                 310                 315                 320         

aat gct gag ggc acc ggt gcc cgc agg ctg gca gcc gcc agc cct gca     1008
Asn Ala Glu Gly Thr Gly Ala Arg Arg Leu Ala Ala Ala Ser Pro Ala         
                325                 330                 335             

ccc aca gcc ccc gag acc ttc cca tac gag aca gcc gtg gcc aag tgc     1056
Pro Thr Ala Pro Glu Thr Phe Pro Tyr Glu Thr Ala Val Ala Lys Cys         
            340                 345                 350                 

aag gag aag ctg ccg gtg gag gac ctg tac tac cag gcc tgc gtc ttc     1104
Lys Glu Lys Leu Pro Val Glu Asp Leu Tyr Tyr Gln Ala Cys Val Phe         
        355                 360                 365                     

gac ctc ctc acc acg ggc gac gtg aac ttc aca ctg gcc gcc tac tac     1152
Asp Leu Leu Thr Thr Gly Asp Val Asn Phe Thr Leu Ala Ala Tyr Tyr         
    370                 375                 380                         

gcg ttg gag gat gtc aag atg ctc cac tcc aac aaa gac aaa ctg cac     1200
Ala Leu Glu Asp Val Lys Met Leu His Ser Asn Lys Asp Lys Leu His         
385                 390                 395                 400         

ctg tat gag agg act cgg gac ctg cca ggc ttg aat tct gca gat atc     1248
Leu Tyr Glu Arg Thr Arg Asp Leu Pro Gly Leu Asn Ser Ala Asp Ile         
                405                 410                 415             

gag gga cga atg gat cca ccg tgc cca gca cct gaa ctc ctg ggg gga     1296
Glu Gly Arg Met Asp Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly         
            420                 425                 430                 

ccg tca gtc ttc ctc ttc ccc cca aaa ccc aag gac acc ctc atg atc     1344
Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile         
        435                 440                 445                     

tcc cgg acc cct gag gtc aca tgc gtg gtg gtg gac gtg agc cac gaa     1392
Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu         
    450                 455                 460                         

gac cct gag gtc aag ttc aac tgg tac gtg gac ggc gtg gag gtg cat     1440
Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His         
465                 470                 475                 480         

aat gcc aag aca aag ccg cgg gag gag cag tac aac agc acg tac cgt     1488
Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg         
                485                 490                 495             

gtg gtc agc gtc ctc acc gtc ctg cac cag gac tgg ctg aat ggc aag     1536
Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys         
            500                 505                 510                 

gag tac aag tgc aag gtc tcc aac aaa gcc ctc cca gcc ccc atc gag     1584
Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu         
        515                 520                 525                     

aaa acc atc tcc aaa gcc aaa ggg cag ccc cga gaa cca cag gtg tac     1632
Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr         
    530                 535                 540                         

acc ctg ccc cca tcc cgg gag gag atg acc aag aac cag gtc agc ctg     1680
Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu         
545                 550                 555                 560         

acc tgc ctg gtc aaa ggc ttc tat ccc agc gac atc gcc gtg gag tgg     1728
Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp         
                565                 570                 575             

gag agc aat ggg cag ccg gag aac aac tac aag acc acg cct ccc gtg     1776
Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val         
            580                 585                 590                 

ctg gac tcc gac ggc tcc ttc ttc ctc tat agc aag ctc acc gtg gac     1824
Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp         
        595                 600                 605                     

aag agc agg tgg cag cag ggg aac gtc ttc tca tgc tcc gtg atg cat     1872
Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His         
    610                 615                 620                         

gag gct ctg cac aac cac tac acg cag aag agc ctc tcc ctg tct ccg     1920
Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro         
625                 630                 635                 640         

ggt aaa tga                                                         1929
Gly Lys                                                                 
                                                                        


<210>  4
<211>  642
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic Construct

<400>  4

Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      


Gly Ser Thr Gly Asp Ala Ala Gln Pro Ala Arg Arg Ala Arg Arg Thr 
            20                  25                  30          


Lys Leu Pro Cys Lys Ile Leu Lys Cys Asn Ser Glu Phe Trp Ser Ala 
        35                  40                  45              


Thr Ser Gly Ser His Ala Pro Ala Ser Asp Asp Thr Pro Glu Phe Cys 
    50                  55                  60                  


Ala Ala Leu Arg Ser Tyr Ala Leu Cys Thr Arg Arg Thr Ala Arg Thr 
65                  70                  75                  80  


Cys Arg Gly Asp Leu Ala Tyr His Ser Ala Val His Gly Ile Glu Asp 
                85                  90                  95      


Leu Met Ser Gln His Asn Cys Ser Lys Asp Gly Pro Thr Ser Gln Pro 
            100                 105                 110         


Arg Leu Arg Thr Leu Pro Pro Ala Gly Asp Ser Gln Glu Arg Ser Asp 
        115                 120                 125             


Ser Pro Glu Ile Cys His Tyr Glu Lys Ser Phe His Lys His Ser Ala 
    130                 135                 140                 


Thr Pro Asn Tyr Thr His Cys Gly Leu Phe Gly Asp Pro His Leu Arg 
145                 150                 155                 160 


Thr Phe Thr Asp Arg Phe Gln Thr Cys Lys Val Gln Gly Ala Trp Pro 
                165                 170                 175     


Leu Ile Asp Asn Asn Tyr Leu Asn Val Gln Val Thr Asn Thr Pro Val 
            180                 185                 190         


Leu Pro Gly Ser Ala Ala Thr Ala Thr Ser Lys Leu Thr Ile Ile Phe 
        195                 200                 205             


Lys Asn Phe Gln Glu Cys Val Asp Gln Lys Val Tyr Gln Ala Glu Met 
    210                 215                 220                 


Asp Glu Leu Pro Ala Ala Phe Val Asp Gly Ser Lys Asn Gly Gly Asp 
225                 230                 235                 240 


Lys His Gly Ala Asn Ser Leu Lys Ile Thr Glu Lys Val Ser Gly Gln 
                245                 250                 255     


His Val Glu Ile Gln Ala Lys Tyr Ile Gly Thr Thr Ile Val Val Arg 
            260                 265                 270         


Gln Val Gly Arg Tyr Leu Thr Phe Ala Val Arg Met Pro Glu Glu Val 
        275                 280                 285             


Val Asn Ala Val Glu Asp Trp Asp Ser Gln Gly Leu Tyr Leu Cys Leu 
    290                 295                 300                 


Arg Gly Cys Pro Leu Asn Gln Gln Ile Asp Phe Gln Ala Phe His Thr 
305                 310                 315                 320 


Asn Ala Glu Gly Thr Gly Ala Arg Arg Leu Ala Ala Ala Ser Pro Ala 
                325                 330                 335     


Pro Thr Ala Pro Glu Thr Phe Pro Tyr Glu Thr Ala Val Ala Lys Cys 
            340                 345                 350         


Lys Glu Lys Leu Pro Val Glu Asp Leu Tyr Tyr Gln Ala Cys Val Phe 
        355                 360                 365             


Asp Leu Leu Thr Thr Gly Asp Val Asn Phe Thr Leu Ala Ala Tyr Tyr 
    370                 375                 380                 


Ala Leu Glu Asp Val Lys Met Leu His Ser Asn Lys Asp Lys Leu His 
385                 390                 395                 400 


Leu Tyr Glu Arg Thr Arg Asp Leu Pro Gly Leu Asn Ser Ala Asp Ile 
                405                 410                 415     


Glu Gly Arg Met Asp Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly 
            420                 425                 430         


Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile 
        435                 440                 445             


Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu 
    450                 455                 460                 


Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His 
465                 470                 475                 480 


Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg 
                485                 490                 495     


Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys 
            500                 505                 510         


Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu 
        515                 520                 525             


Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr 
    530                 535                 540                 


Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu 
545                 550                 555                 560 


Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp 
                565                 570                 575     


Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val 
            580                 585                 590         


Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp 
        595                 600                 605             


Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His 
    610                 615                 620                 


Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro 
625                 630                 635                 640 


Gly Lys 
        


<210>  5
<211>  1167
<212>  DNA
<213>  Artificial

<220>
<223>  hRGMA LC fc


<220>
<221>  CDS
<222>  (1)..(1167)

<220>
<221>  sig_peptide
<222>  (1)..(102)

<220>
<221>  misc_feature
<222>  (103)..(468)
<223>  hRGMA Fragment 47-168

<220>
<221>  misc_feature
<222>  (469)..(1167)
<223>  fc portion

<400>  5
atg gag aca gac aca ctc ctg cta tgg gta ctg ctg ctc tgg gtt cca       48
Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro         
1               5                   10                  15              

ggt tcc act ggt gac gcg gcc cag ccg gcc agg cgc gcg cgc cgt acg       96
Gly Ser Thr Gly Asp Ala Ala Gln Pro Ala Arg Arg Ala Arg Arg Thr         
            20                  25                  30                  

aag ctt ccg tgc aag atc ctc aag tgc aac tct gag ttc tgg agc gcc      144
Lys Leu Pro Cys Lys Ile Leu Lys Cys Asn Ser Glu Phe Trp Ser Ala         
        35                  40                  45                      

acg tcg ggc agc cac gcc cca gcc tca gac gac acc ccc gag ttc tgt      192
Thr Ser Gly Ser His Ala Pro Ala Ser Asp Asp Thr Pro Glu Phe Cys         
    50                  55                  60                          

gca gcc ttg cgc agc tac gcc ctg tgc acg cgg cgg acg gcc cgc acc      240
Ala Ala Leu Arg Ser Tyr Ala Leu Cys Thr Arg Arg Thr Ala Arg Thr         
65                  70                  75                  80          

tgc cgg ggt gac ctg gcc tac cac tcg gcc gtc cat ggc ata gag gac      288
Cys Arg Gly Asp Leu Ala Tyr His Ser Ala Val His Gly Ile Glu Asp         
                85                  90                  95              

ctc atg agc cag cac aac tgc tcc aag gat ggc ccc acc tcg cag cca      336
Leu Met Ser Gln His Asn Cys Ser Lys Asp Gly Pro Thr Ser Gln Pro         
            100                 105                 110                 

cgc ctg cgc acg ctc cca ccg gcc gga gac agc cag gag cgc tcg gac      384
Arg Leu Arg Thr Leu Pro Pro Ala Gly Asp Ser Gln Glu Arg Ser Asp         
        115                 120                 125                     

agc ccc gag atc tgc cat tac gag aag agc ttt cac aag cac tcg gcc      432
Ser Pro Glu Ile Cys His Tyr Glu Lys Ser Phe His Lys His Ser Ala         
    130                 135                 140                         

acc ccc aac tac acg cac tgt ggc ctc ttc ggg gac ttg aat tct gca      480
Thr Pro Asn Tyr Thr His Cys Gly Leu Phe Gly Asp Leu Asn Ser Ala         
145                 150                 155                 160         

gat atc gag gga cga atg gat cca ccg tgc cca gca cct gaa ctc ctg      528
Asp Ile Glu Gly Arg Met Asp Pro Pro Cys Pro Ala Pro Glu Leu Leu         
                165                 170                 175             

ggg gga ccg tca gtc ttc ctc ttc ccc cca aaa ccc aag gac acc ctc      576
Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu         
            180                 185                 190                 

atg atc tcc cgg acc cct gag gtc aca tgc gtg gtg gtg gac gtg agc      624
Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser         
        195                 200                 205                     

cac gaa gac cct gag gtc aag ttc aac tgg tac gtg gac ggc gtg gag      672
His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu         
    210                 215                 220                         

gtg cat aat gcc aag aca aag ccg cgg gag gag cag tac aac agc acg      720
Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr         
225                 230                 235                 240         

tac cgt gtg gtc agc gtc ctc acc gtc ctg cac cag gac tgg ctg aat      768
Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn         
                245                 250                 255             

ggc aag gag tac aag tgc aag gtc tcc aac aaa gcc ctc cca gcc ccc      816
Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro         
            260                 265                 270                 

atc gag aaa acc atc tcc aaa gcc aaa ggg cag ccc cga gaa cca cag      864
Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln         
        275                 280                 285                     

gtg tac acc ctg ccc cca tcc cgg gag gag atg acc aag aac cag gtc      912
Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val         
    290                 295                 300                         

agc ctg acc tgc ctg gtc aaa ggc ttc tat ccc agc gac atc gcc gtg      960
Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val         
305                 310                 315                 320         

gag tgg gag agc aat ggg cag ccg gag aac aac tac aag acc acg cct     1008
Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro         
                325                 330                 335             

ccc gtg ctg gac tcc gac ggc tcc ttc ttc ctc tat agc aag ctc acc     1056
Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr         
            340                 345                 350                 

gtg gac aag agc agg tgg cag cag ggg aac gtc ttc tca tgc tcc gtg     1104
Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val         
        355                 360                 365                     

atg cat gag gct ctg cac aac cac tac acg cag aag agc ctc tcc ctg     1152
Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu         
    370                 375                 380                         

tct ccg ggt aaa tga                                                 1167
Ser Pro Gly Lys                                                         
385                                                                     


<210>  6
<211>  388
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic Construct

<400>  6

Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      


Gly Ser Thr Gly Asp Ala Ala Gln Pro Ala Arg Arg Ala Arg Arg Thr 
            20                  25                  30          


Lys Leu Pro Cys Lys Ile Leu Lys Cys Asn Ser Glu Phe Trp Ser Ala 
        35                  40                  45              


Thr Ser Gly Ser His Ala Pro Ala Ser Asp Asp Thr Pro Glu Phe Cys 
    50                  55                  60                  


Ala Ala Leu Arg Ser Tyr Ala Leu Cys Thr Arg Arg Thr Ala Arg Thr 
65                  70                  75                  80  


Cys Arg Gly Asp Leu Ala Tyr His Ser Ala Val His Gly Ile Glu Asp 
                85                  90                  95      


Leu Met Ser Gln His Asn Cys Ser Lys Asp Gly Pro Thr Ser Gln Pro 
            100                 105                 110         


Arg Leu Arg Thr Leu Pro Pro Ala Gly Asp Ser Gln Glu Arg Ser Asp 
        115                 120                 125             


Ser Pro Glu Ile Cys His Tyr Glu Lys Ser Phe His Lys His Ser Ala 
    130                 135                 140                 


Thr Pro Asn Tyr Thr His Cys Gly Leu Phe Gly Asp Leu Asn Ser Ala 
145                 150                 155                 160 


Asp Ile Glu Gly Arg Met Asp Pro Pro Cys Pro Ala Pro Glu Leu Leu 
                165                 170                 175     


Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu 
            180                 185                 190         


Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser 
        195                 200                 205             


His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu 
    210                 215                 220                 


Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr 
225                 230                 235                 240 


Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn 
                245                 250                 255     


Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro 
            260                 265                 270         


Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln 
        275                 280                 285             


Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val 
    290                 295                 300                 


Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val 
305                 310                 315                 320 


Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro 
                325                 330                 335     


Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr 
            340                 345                 350         


Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val 
        355                 360                 365             


Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu 
    370                 375                 380                 


Ser Pro Gly Lys 
385             


<210>  7
<211>  1431
<212>  DNA
<213>  Rattus sp.


<220>
<221>  CDS
<222>  (1)..(1431)

<400>  7
atg gag aca gac aca ctc ctg cta tgg gta ctg ctg ctc tgg gtt cca       48
Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro         
1               5                   10                  15              

ggt tcc act ggt gac gcg gcc cag ccg gcc agg cgc gcg cgc cgt acg       96
Gly Ser Thr Gly Asp Ala Ala Gln Pro Ala Arg Arg Ala Arg Arg Thr         
            20                  25                  30                  

aag ctt ggt acc gag ctc gga tcc act agt cca gtg tgg tgg aat tct      144
Lys Leu Gly Thr Glu Leu Gly Ser Thr Ser Pro Val Trp Trp Asn Ser         
        35                  40                  45                      

gca gat atc aca agt ttg tac aaa aaa gca ggc tcc ccg tgc aag atc      192
Ala Asp Ile Thr Ser Leu Tyr Lys Lys Ala Gly Ser Pro Cys Lys Ile         
    50                  55                  60                          

ctc aag tgc aac tct gag ttc tgg agc gcc acg tcg tca ggc agc cac      240
Leu Lys Cys Asn Ser Glu Phe Trp Ser Ala Thr Ser Ser Gly Ser His         
65                  70                  75                  80          

gcc cct gcc tct gac gac gtg ccc gag ttc tgt gct gcc ctg cgc acc      288
Ala Pro Ala Ser Asp Asp Val Pro Glu Phe Cys Ala Ala Leu Arg Thr         
                85                  90                  95              

tac gcc ctg tgc acg cga cgg aca gcc cgc acc tgc cgg ggc gac ctg      336
Tyr Ala Leu Cys Thr Arg Arg Thr Ala Arg Thr Cys Arg Gly Asp Leu         
            100                 105                 110                 

gct tac cac tcg gct gtc cat ggc ata gag gac ctc atg agc cag cac      384
Ala Tyr His Ser Ala Val His Gly Ile Glu Asp Leu Met Ser Gln His         
        115                 120                 125                     

aac tgc tcc aag gat ggc ccc acc tca cag cct cga gtg cgc acg ctc      432
Asn Cys Ser Lys Asp Gly Pro Thr Ser Gln Pro Arg Val Arg Thr Leu         
    130                 135                 140                         

ccg cca gct ggg gac agc cag gag cgc tca gat agc ccc gag atc tgc      480
Pro Pro Ala Gly Asp Ser Gln Glu Arg Ser Asp Ser Pro Glu Ile Cys         
145                 150                 155                 160         

cac tat gag aag agt ttc cac aag cac tca gct gcc ccc aac tac act      528
His Tyr Glu Lys Ser Phe His Lys His Ser Ala Ala Pro Asn Tyr Thr         
                165                 170                 175             

cac tgc ggc ctc ttt ggg gac cca cac ctc agg act ttc aca gac cac      576
His Cys Gly Leu Phe Gly Asp Pro His Leu Arg Thr Phe Thr Asp His         
            180                 185                 190                 

ttc cag aca tgt aag gtg caa ggc gct tgg cct ctc atc gac aat aat      624
Phe Gln Thr Cys Lys Val Gln Gly Ala Trp Pro Leu Ile Asp Asn Asn         
        195                 200                 205                     

tac ctg aac gtg cag gtc acc aat aca cct gtg ctg ccc ggc tct gcc      672
Tyr Leu Asn Val Gln Val Thr Asn Thr Pro Val Leu Pro Gly Ser Ala         
    210                 215                 220                         

gcc act gcc acc agc aag ctc acc atc atc ttc aag aac ttc caa gag      720
Ala Thr Ala Thr Ser Lys Leu Thr Ile Ile Phe Lys Asn Phe Gln Glu         
225                 230                 235                 240         

tgt gtg gac cag aaa gta tac caa gcc gag atg gac gag ctt ccg tcc      768
Cys Val Asp Gln Lys Val Tyr Gln Ala Glu Met Asp Glu Leu Pro Ser         
                245                 250                 255             

gcc ttt gcc gat ggc tcc aaa aac ggt gga gat aaa cac gga gcc aac      816
Ala Phe Ala Asp Gly Ser Lys Asn Gly Gly Asp Lys His Gly Ala Asn         
            260                 265                 270                 

agc ctg aag atc aca gag aag gtg tca ggc cag cac gtg gag atc cag      864
Ser Leu Lys Ile Thr Glu Lys Val Ser Gly Gln His Val Glu Ile Gln         
        275                 280                 285                     

gcc aag tac atc ggc acc acc atc gtg gtg aga cag gtg ggc cgc tac      912
Ala Lys Tyr Ile Gly Thr Thr Ile Val Val Arg Gln Val Gly Arg Tyr         
    290                 295                 300                         

ctg acc ttc gcc gtc cgg atg ccc gag gag gta gtc aac gcc gtg gag      960
Leu Thr Phe Ala Val Arg Met Pro Glu Glu Val Val Asn Ala Val Glu         
305                 310                 315                 320         

gac cgt gac agc caa ggc ctc tac ctc tgc ctg cgg ggc tgc ccg ctc     1008
Asp Arg Asp Ser Gln Gly Leu Tyr Leu Cys Leu Arg Gly Cys Pro Leu         
                325                 330                 335             

aac cag cag atc gac ttc cag gct ttc cgt gcc aac gcc gag agc cct     1056
Asn Gln Gln Ile Asp Phe Gln Ala Phe Arg Ala Asn Ala Glu Ser Pro         
            340                 345                 350                 

cgc agg cca gca gct gcc agc ccc tct cct gtg gtc ccc gag aca ttt     1104
Arg Arg Pro Ala Ala Ala Ser Pro Ser Pro Val Val Pro Glu Thr Phe         
        355                 360                 365                     

ccg tac gag aca gct gtg gcc aag tgc aaa gag aag ctg cct gta gaa     1152
Pro Tyr Glu Thr Ala Val Ala Lys Cys Lys Glu Lys Leu Pro Val Glu         
    370                 375                 380                         

gac ttg tac tac cag gcc tgt gtc ttc gac ctc ctc acg act ggc gac     1200
Asp Leu Tyr Tyr Gln Ala Cys Val Phe Asp Leu Leu Thr Thr Gly Asp         
385                 390                 395                 400         

gtg aac ttc acg ctg gcc gcc tac tat gct ttg gag gat ggc aag atg     1248
Val Asn Phe Thr Leu Ala Ala Tyr Tyr Ala Leu Glu Asp Gly Lys Met         
                405                 410                 415             

ctc cac tcc aac aag gac aag cta cac ctg ttt gaa agg act cgg gag     1296
Leu His Ser Asn Lys Asp Lys Leu His Leu Phe Glu Arg Thr Arg Glu         
            420                 425                 430                 

ctg cct gac cca gct ttc ttg tac aaa gtg gtg ata tcc agc aca gtg     1344
Leu Pro Asp Pro Ala Phe Leu Tyr Lys Val Val Ile Ser Ser Thr Val         
        435                 440                 445                     

gcg gcc gct cga gga ggg ccc gaa caa aaa ctc atc tca gaa gag gat     1392
Ala Ala Ala Arg Gly Gly Pro Glu Gln Lys Leu Ile Ser Glu Glu Asp         
    450                 455                 460                         

ctg aat agc gcc gtc gac cat cat cat cat cat cat tga                 1431
Leu Asn Ser Ala Val Asp His His His His His His                         
465                 470                 475                             


<210>  8
<211>  476
<212>  PRT
<213>  Rattus sp.

<400>  8

Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      


Gly Ser Thr Gly Asp Ala Ala Gln Pro Ala Arg Arg Ala Arg Arg Thr 
            20                  25                  30          


Lys Leu Gly Thr Glu Leu Gly Ser Thr Ser Pro Val Trp Trp Asn Ser 
        35                  40                  45              


Ala Asp Ile Thr Ser Leu Tyr Lys Lys Ala Gly Ser Pro Cys Lys Ile 
    50                  55                  60                  


Leu Lys Cys Asn Ser Glu Phe Trp Ser Ala Thr Ser Ser Gly Ser His 
65                  70                  75                  80  


Ala Pro Ala Ser Asp Asp Val Pro Glu Phe Cys Ala Ala Leu Arg Thr 
                85                  90                  95      


Tyr Ala Leu Cys Thr Arg Arg Thr Ala Arg Thr Cys Arg Gly Asp Leu 
            100                 105                 110         


Ala Tyr His Ser Ala Val His Gly Ile Glu Asp Leu Met Ser Gln His 
        115                 120                 125             


Asn Cys Ser Lys Asp Gly Pro Thr Ser Gln Pro Arg Val Arg Thr Leu 
    130                 135                 140                 


Pro Pro Ala Gly Asp Ser Gln Glu Arg Ser Asp Ser Pro Glu Ile Cys 
145                 150                 155                 160 


His Tyr Glu Lys Ser Phe His Lys His Ser Ala Ala Pro Asn Tyr Thr 
                165                 170                 175     


His Cys Gly Leu Phe Gly Asp Pro His Leu Arg Thr Phe Thr Asp His 
            180                 185                 190         


Phe Gln Thr Cys Lys Val Gln Gly Ala Trp Pro Leu Ile Asp Asn Asn 
        195                 200                 205             


Tyr Leu Asn Val Gln Val Thr Asn Thr Pro Val Leu Pro Gly Ser Ala 
    210                 215                 220                 


Ala Thr Ala Thr Ser Lys Leu Thr Ile Ile Phe Lys Asn Phe Gln Glu 
225                 230                 235                 240 


Cys Val Asp Gln Lys Val Tyr Gln Ala Glu Met Asp Glu Leu Pro Ser 
                245                 250                 255     


Ala Phe Ala Asp Gly Ser Lys Asn Gly Gly Asp Lys His Gly Ala Asn 
            260                 265                 270         


Ser Leu Lys Ile Thr Glu Lys Val Ser Gly Gln His Val Glu Ile Gln 
        275                 280                 285             


Ala Lys Tyr Ile Gly Thr Thr Ile Val Val Arg Gln Val Gly Arg Tyr 
    290                 295                 300                 


Leu Thr Phe Ala Val Arg Met Pro Glu Glu Val Val Asn Ala Val Glu 
305                 310                 315                 320 


Asp Arg Asp Ser Gln Gly Leu Tyr Leu Cys Leu Arg Gly Cys Pro Leu 
                325                 330                 335     


Asn Gln Gln Ile Asp Phe Gln Ala Phe Arg Ala Asn Ala Glu Ser Pro 
            340                 345                 350         


Arg Arg Pro Ala Ala Ala Ser Pro Ser Pro Val Val Pro Glu Thr Phe 
        355                 360                 365             


Pro Tyr Glu Thr Ala Val Ala Lys Cys Lys Glu Lys Leu Pro Val Glu 
    370                 375                 380                 


Asp Leu Tyr Tyr Gln Ala Cys Val Phe Asp Leu Leu Thr Thr Gly Asp 
385                 390                 395                 400 


Val Asn Phe Thr Leu Ala Ala Tyr Tyr Ala Leu Glu Asp Gly Lys Met 
                405                 410                 415     


Leu His Ser Asn Lys Asp Lys Leu His Leu Phe Glu Arg Thr Arg Glu 
            420                 425                 430         


Leu Pro Asp Pro Ala Phe Leu Tyr Lys Val Val Ile Ser Ser Thr Val 
        435                 440                 445             


Ala Ala Ala Arg Gly Gly Pro Glu Gln Lys Leu Ile Ser Glu Glu Asp 
    450                 455                 460                 


Leu Asn Ser Ala Val Asp His His His His His His 
465                 470                 475     


<210>  9
<211>  115
<212>  PRT
<213>  Artificial

<220>
<223>  VH 5F9


<220>
<221>  misc_feature
<222>  (62)..(62)
<223>  Xaa can be any naturally occurring amino acid

<400>  9

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Ser 
1               5                   10                  15      


Ser Leu Lys Leu Ser Cys Val Ala Ser Gly Phe Thr Phe Ser Asn Tyr 
            20                  25                  30          


Gly Met Asn Trp Ile Arg Gln Ala Pro Lys Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Met Ile Tyr Tyr Asp Ser Ser Glu Lys His Tyr Ala Xaa Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Glu Met Asn Ser Leu Arg Ser Glu Asp Thr Ala Ile Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Gly Thr Thr Pro Asp Tyr Trp Gly Gln Gly Val Met Val Thr 
            100                 105                 110         


Val Ser Ser 
        115 


<210>  10
<211>  113
<212>  PRT
<213>  Artificial

<220>
<223>  VL 5F9

<400>  10

Asp Val Val Leu Thr Gln Thr Pro Val Ser Leu Ser Val Thr Leu Gly 
1               5                   10                  15      


Asp Gln Ala Ser Met Ser Cys Arg Ser Ser Gln Ser Leu Glu Tyr Ser 
            20                  25                  30          


Asp Gly Tyr Thr Phe Leu Glu Trp Phe Leu Gln Lys Pro Gly Gln Ser 
        35                  40                  45              


Pro Gln Leu Leu Ile Tyr Glu Val Ser Asn Arg Phe Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ile Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Pro Glu Asp Leu Gly Val Tyr Tyr Cys Phe Gln Ala 
                85                  90                  95      


Thr His Asp Pro Leu Thr Phe Gly Ser Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         


Arg 
    


<210>  11
<211>  330
<212>  PRT
<213>  Artificial

<220>
<223>  Ig gamma-1 constant region

<400>  11

Ala Ser Thr Lys Gly Pro Ser Val Phe Phe Leu Ala Pro Ser Ser Lys 
1               5                   10                  15      


Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr 
65                  70                  75                  80  


Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      


Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys 
            100                 105                 110         


Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro 
        115                 120                 125             


Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 
    130                 135                 140                 


Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp 
145                 150                 155                 160 


Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 
                165                 170                 175     


Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 
            180                 185                 190         


His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 
        195                 200                 205             


Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 
    210                 215                 220                 


Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu 
225                 230                 235                 240 


Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr 
                245                 250                 255     


Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 
            260                 265                 270         


Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 
        275                 280                 285             


Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn 
    290                 295                 300                 


Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 
305                 310                 315                 320 


Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
                325                 330 


<210>  12
<211>  330
<212>  PRT
<213>  Artificial

<220>
<223>  Ig gamma-1 constant region mutant

<400>  12

Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys 
1               5                   10                  15      


Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr 
65                  70                  75                  80  


Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      


Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys 
            100                 105                 110         


Pro Ala Pro Glu Ala Ala Gly Gly Pro Ser Val Phe Leu Phe Pro Pro 
        115                 120                 125             


Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 
    130                 135                 140                 


Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp 
145                 150                 155                 160 


Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 
                165                 170                 175     


Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 
            180                 185                 190         


His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 
        195                 200                 205             


Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 
    210                 215                 220                 


Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu 
225                 230                 235                 240 


Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr 
                245                 250                 255     


Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 
            260                 265                 270         


Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 
        275                 280                 285             


Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn 
    290                 295                 300                 


Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 
305                 310                 315                 320 


Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
                325                 330 


<210>  13
<211>  106
<212>  PRT
<213>  Artificial

<220>
<223>  Ig Kappa constant region

<400>  13

Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln 
1               5                   10                  15      


Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr 
            20                  25                  30          


Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser 
        35                  40                  45              


Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr 
    50                  55                  60                  


Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys 
65                  70                  75                  80  


His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro 
                85                  90                  95      


Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
            100                 105     


<210>  14
<211>  105
<212>  PRT
<213>  Artificial

<220>
<223>  lg Lambda constant region

<400>  14

Gln Pro Lys Ala Ala Pro Ser Val Thr Leu Phe Pro Pro Ser Ser Glu 
1               5                   10                  15      


Glu Leu Gln Ala Asn Lys Ala Thr Leu Val Cys Leu Ile Ser Asp Phe 
            20                  25                  30          


Tyr Pro Gly Ala Val Thr Val Ala Trp Lys Ala Asp Ser Ser Pro Val 
        35                  40                  45              


Lys Ala Gly Val Glu Thr Thr Thr Pro Ser Lys Gln Ser Asn Asn Lys 
    50                  55                  60                  


Tyr Ala Ala Ser Ser Tyr Leu Ser Leu Thr Pro Glu Gln Trp Lys Ser 
65                  70                  75                  80  


His Arg Ser Tyr Ser Cys Gln Val Thr His Glu Gly Ser Thr Val Glu 
                85                  90                  95      


Lys Thr Val Ala Pro Thr Glu Cys Ser 
            100                 105 


<210>  15
<211>  30
<212>  PRT
<213>  Artificial

<220>
<223>  VH3-48/JH3 FR1

<400>  15

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser 
            20                  25                  30  


<210>  16
<211>  14
<212>  PRT
<213>  Artificial

<220>
<223>  VH3-48/JH3 FR2

<400>  16

Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ser 
1               5                   10                  


<210>  17
<211>  32
<212>  PRT
<213>  Artificial

<220>
<223>  VH3-48/JH3 FR3

<400>  17

Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr Leu Gln 
1               5                   10                  15      


Met Asn Ser Leu Arg Asp Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  18
<211>  11
<212>  PRT
<213>  Artificial

<220>
<223>  VH3-49/JH3 FR4

<400>  18

Trp Gly Gln Gly Thr Met Val Thr Val Ser Ser 
1               5                   10      


<210>  19
<211>  11
<212>  PRT
<213>  Artificial

<220>
<223>  VH3-48/JH4 FR4

<400>  19

Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
1               5                   10      


<210>  20
<211>  11
<212>  PRT
<213>  Artificial

<220>
<223>  VH3-48/JH6 FR4

<400>  20

Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 
1               5                   10      


<210>  21
<211>  30
<212>  PRT
<213>  Artificial

<220>
<223>  VH3-33/JH6 FR!

<400>  21

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser 
            20                  25                  30  


<210>  22
<211>  14
<212>  PRT
<213>  Artificial

<220>
<223>  VH3-33/JH6 FR2

<400>  22

Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ala 
1               5                   10                  


<210>  23
<211>  32
<212>  PRT
<213>  Artificial

<220>
<223>  VH3-33/JH6 FR3

<400>  23

Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu Gln 
1               5                   10                  15      


Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  24
<211>  30
<212>  PRT
<213>  Artificial

<220>
<223>  VH3-23/JH3 FR1

<400>  24

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser 
            20                  25                  30  


<210>  25
<211>  14
<212>  PRT
<213>  Artificial

<220>
<223>  VH3-23/JH3 FR2

<400>  25

Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ser 
1               5                   10                  


<210>  26
<211>  32
<212>  PRT
<213>  Artificial

<220>
<223>  VH3-23/JH3 FR3

<400>  26

Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu Gln 
1               5                   10                  15      


Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Lys 
            20                  25                  30          


<210>  27
<211>  23
<212>  PRT
<213>  Artificial

<220>
<223>  A18/JK2 FR1

<400>  27

Asp Ile Val Met Thr Gln Thr Pro Leu Ser Leu Ser Val Thr Pro Gly 
1               5                   10                  15      


Gln Pro Ala Ser Ile Ser Cys 
            20              


<210>  28
<211>  15
<212>  PRT
<213>  Artificial

<220>
<223>  A18/JK2 FR2

<400>  28

Trp Tyr Leu Gln Lys Pro Gly Gln Ser Pro Gln Leu Leu Ile Tyr 
1               5                   10                  15  


<210>  29
<211>  32
<212>  PRT
<213>  Artificial

<220>
<223>  A18/JK2 FR3

<400>  29

Gly Val Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr 
1               5                   10                  15      


Leu Lys Ile Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys 
            20                  25                  30          


<210>  30
<211>  11
<212>  PRT
<213>  Artificial

<220>
<223>  A18/JK2 FR4

<400>  30

Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys Arg 
1               5                   10      


<210>  31
<211>  23
<212>  PRT
<213>  Artificial

<220>
<223>  A17/JK2 FR1

<400>  31

Asp Val Val Met Thr Gln Ser Pro Leu Ser Leu Pro Val Thr Leu Gly 
1               5                   10                  15      


Gln Pro Ala Ser Ile Ser Cys 
            20              


<210>  32
<211>  15
<212>  PRT
<213>  Artificial

<220>
<223>  A17/JK2 FR2

<400>  32

Trp Phe Gln Gln Arg Pro Gly Gln Ser Pro Arg Arg Leu Ile Tyr 
1               5                   10                  15  


<210>  33
<211>  32
<212>  PRT
<213>  Artificial

<220>
<223>  A17/JK2 FR3

<400>  33

Gly Val Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr 
1               5                   10                  15      


Leu Lys Ile Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys 
            20                  25                  30          


<210>  34
<211>  115
<212>  PRT
<213>  Artificial

<220>
<223>  VH 5F9

<400>  34

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Ser 
1               5                   10                  15      


Ser Leu Lys Leu Ser Cys Val Ala Ser Gly Phe Thr Phe Ser Asn Tyr 
            20                  25                  30          


Gly Met Asn Trp Ile Arg Gln Ala Pro Lys Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Met Ile Tyr Tyr Asp Ser Ser Glu Lys His Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Glu Met Asn Ser Leu Arg Ser Glu Asp Thr Ala Ile Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Gly Thr Thr Pro Asp Tyr Trp Gly Gln Gly Val Met Val Thr 
            100                 105                 110         


Val Ser Ser 
        115 


<210>  35
<211>  115
<212>  PRT
<213>  Artificial

<220>
<223>  VH 5F9.1-GL

<400>  35

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Tyr 
            20                  25                  30          


Gly Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Met Ile Tyr Tyr Asp Ser Ser Glu Lys His Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Asp Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Thr Thr Pro Asp Tyr Trp Gly Gln Gly Thr Met Val Thr 
            100                 105                 110         


Val Ser Ser 
        115 


<210>  36
<211>  115
<212>  PRT
<213>  Artificial

<220>
<223>  VH 5F9.2-GL

<400>  36

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Tyr 
            20                  25                  30          


Gly Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Met Ile Tyr Tyr Asp Ser Ser Glu Lys His Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Asp Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Thr Thr Pro Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr 
            100                 105                 110         


Val Ser Ser 
        115 


<210>  37
<211>  115
<212>  PRT
<213>  Artificial

<220>
<223>  VH 5F9.3-GL

<400>  37

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Tyr 
            20                  25                  30          


Gly Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Met Ile Tyr Tyr Asp Ser Ser Glu Lys His Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Asp Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Thr Thr Pro Asp Tyr Trp Gly Gln Gly Thr Thr Val Thr 
            100                 105                 110         


Val Ser Ser 
        115 


<210>  38
<211>  115
<212>  PRT
<213>  Artificial

<220>
<223>  VH 5F9.4-GL

<400>  38

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Tyr 
            20                  25                  30          


Gly Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Met Ile Tyr Tyr Asp Ser Ser Glu Lys His Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Thr Thr Pro Asp Tyr Trp Gly Gln Gly Thr Met Val Thr 
            100                 105                 110         


Val Ser Ser 
        115 


<210>  39
<211>  115
<212>  PRT
<213>  Artificial

<220>
<223>  VH 5F9.5-GL

<400>  39

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Tyr 
            20                  25                  30          


Gly Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Met Ile Tyr Tyr Asp Ser Ser Glu Lys His Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Thr Thr Pro Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr 
            100                 105                 110         


Val Ser Ser 
        115 


<210>  40
<211>  115
<212>  PRT
<213>  Artificial

<220>
<223>  VH 5F9.6-GL

<400>  40

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Tyr 
            20                  25                  30          


Gly Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Met Ile Tyr Tyr Asp Ser Ser Glu Lys His Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Thr Thr Pro Asp Tyr Trp Gly Gln Gly Thr Thr Val Thr 
            100                 105                 110         


Val Ser Ser 
        115 


<210>  41
<211>  115
<212>  PRT
<213>  Artificial

<220>
<223>  VH 5F9.7-GL

<400>  41

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Tyr 
            20                  25                  30          


Gly Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Met Ile Tyr Tyr Asp Ser Ser Glu Lys His Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Gly Thr Thr Pro Asp Tyr Trp Gly Gln Gly Thr Met Val Thr 
            100                 105                 110         


Val Ser Ser 
        115 


<210>  42
<211>  115
<212>  PRT
<213>  Artificial

<220>
<223>  VH 5F9.8-GL

<400>  42

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Tyr 
            20                  25                  30          


Gly Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Met Ile Tyr Tyr Asp Ser Ser Glu Lys His Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Gly Thr Thr Pro Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr 
            100                 105                 110         


Val Ser Ser 
        115 


<210>  43
<211>  115
<212>  PRT
<213>  Artificial

<220>
<223>  VH 5F9.9-GL

<400>  43

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Tyr 
            20                  25                  30          


Gly Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Met Ile Tyr Tyr Asp Ser Ser Glu Lys His Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Gly Thr Thr Pro Asp Tyr Trp Gly Gln Gly Thr Thr Val Thr 
            100                 105                 110         


Val Ser Ser 
        115 


<210>  44
<211>  113
<212>  PRT
<213>  Artificial

<220>
<223>  VL 5F9.1-GL

<400>  44

Asp Ile Val Met Thr Gln Thr Pro Leu Ser Leu Ser Val Thr Pro Gly 
1               5                   10                  15      


Gln Pro Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Glu Tyr Ser 
            20                  25                  30          


Asp Gly Tyr Thr Phe Leu Glu Trp Tyr Leu Gln Lys Pro Gly Gln Ser 
        35                  40                  45              


Pro Gln Leu Leu Ile Tyr Glu Val Ser Asn Arg Phe Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Phe Gln Ala 
                85                  90                  95      


Thr His Asp Pro Leu Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         


Arg 
    


<210>  45
<211>  113
<212>  PRT
<213>  Artificial

<220>
<223>  VL 5F9.2-GL

<400>  45

Asp Val Val Met Thr Gln Ser Pro Leu Ser Leu Pro Val Thr Leu Gly 
1               5                   10                  15      


Gln Pro Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Glu Tyr Ser 
            20                  25                  30          


Asp Gly Tyr Thr Phe Leu Glu Trp Phe Gln Gln Arg Pro Gly Gln Ser 
        35                  40                  45              


Pro Arg Arg Leu Ile Tyr Glu Val Ser Asn Arg Phe Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Phe Gln Ala 
                85                  90                  95      


Thr His Asp Pro Leu Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         


Arg 
    


<210>  46
<211>  113
<212>  PRT
<213>  Artificial

<220>
<223>  VL 5F9.3-GL

<400>  46

Asp Val Val Met Thr Gln Ser Pro Leu Ser Leu Pro Val Thr Leu Gly 
1               5                   10                  15      


Gln Pro Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Glu Tyr Ser 
            20                  25                  30          


Asp Gly Tyr Thr Phe Leu Glu Trp Tyr Leu Gln Lys Pro Gly Gln Ser 
        35                  40                  45              


Pro Gln Leu Leu Ile Tyr Glu Val Ser Asn Arg Phe Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Phe Gln Ala 
                85                  90                  95      


Thr His Asp Pro Leu Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         


Arg 
    


<210>  47
<211>  115
<212>  PRT
<213>  Artificial

<220>
<223>  VH h5F9.1

<400>  47

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Tyr 
            20                  25                  30          


Gly Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Met Ile Tyr Tyr Asp Ser Ser Glu Lys His Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Thr Thr Pro Asp Tyr Trp Gly Gln Gly Thr Met Val Thr 
            100                 105                 110         


Val Ser Ser 
        115 


<210>  48
<211>  115
<212>  PRT
<213>  Artificial

<220>
<223>  VH h5F9.2

<400>  48

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Tyr 
            20                  25                  30          


Gly Met Asn Trp Ile Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Met Ile Tyr Tyr Asp Ser Ser Glu Lys His Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Gly Thr Thr Pro Asp Tyr Trp Gly Gln Gly Thr Met Val Thr 
            100                 105                 110         


Val Ser Ser 
        115 


<210>  49
<211>  115
<212>  PRT
<213>  Artificial

<220>
<223>  VH h5F9.3

<400>  49

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Tyr 
            20                  25                  30          


Gly Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Met Ile Tyr Tyr Asp Ser Ser Glu Lys His Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Gly Thr Thr Pro Asp Tyr Trp Gly Gln Gly Thr Met Val Thr 
            100                 105                 110         


Val Ser Ser 
        115 


<210>  50
<211>  115
<212>  PRT
<213>  Artificial

<220>
<223>  VH h5F9.4

<400>  50

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Tyr 
            20                  25                  30          


Gly Met Asn Trp Ile Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Met Ile Tyr Tyr Asp Ser Ser Glu Lys His Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Gly Thr Thr Pro Asp Tyr Trp Gly Gln Gly Thr Met Val Thr 
            100                 105                 110         


Val Ser Ser 
        115 


<210>  51
<211>  113
<212>  PRT
<213>  Artificial

<220>
<223>  VL h5F9.19

<400>  51

Asp Val Val Leu Thr Gln Ser Pro Leu Ser Leu Pro Val Thr Leu Gly 
1               5                   10                  15      


Gln Pro Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Glu Tyr Ser 
            20                  25                  30          


Asp Gly Tyr Thr Phe Leu Glu Trp Phe Gln Gln Arg Pro Gly Gln Ser 
        35                  40                  45              


Pro Arg Leu Leu Ile Tyr Glu Val Ser Asn Arg Phe Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Phe Gln Ala 
                85                  90                  95      


Thr His Asp Pro Leu Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         


Arg 
    


<210>  52
<211>  113
<212>  PRT
<213>  Artificial

<220>
<223>  VL h5F9.20

<400>  52

Asp Val Val Leu Thr Gln Ser Pro Leu Ser Leu Pro Val Thr Leu Gly 
1               5                   10                  15      


Gln Pro Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Glu Tyr Ser 
            20                  25                  30          


Asp Gly Tyr Thr Phe Leu Glu Trp Phe Gln Gln Arg Pro Gly Gln Ser 
        35                  40                  45              


Pro Arg Arg Leu Ile Tyr Glu Val Ser Asn Arg Phe Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Phe Gln Ala 
                85                  90                  95      


Thr His Asp Pro Leu Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         


Arg 
    


<210>  53
<211>  113
<212>  PRT
<213>  Artificial

<220>
<223>  VL h5F9.21

<400>  53

Asp Val Val Leu Thr Gln Ser Pro Leu Ser Leu Pro Val Thr Leu Gly 
1               5                   10                  15      


Gln Pro Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Glu Tyr Ser 
            20                  25                  30          


Asp Gly Tyr Thr Phe Leu Glu Trp Phe Leu Gln Lys Pro Gly Gln Ser 
        35                  40                  45              


Pro Gln Leu Leu Ile Tyr Glu Val Ser Asn Arg Phe Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Phe Gln Ala 
                85                  90                  95      


Thr His Asp Pro Leu Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         


Arg 
    


<210>  54
<211>  113
<212>  PRT
<213>  Artificial

<220>
<223>  VL h5F9.22

<400>  54

Asp Val Val Leu Thr Gln Ser Pro Leu Ser Leu Pro Val Thr Leu Gly 
1               5                   10                  15      


Gln Pro Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Glu Tyr Ser 
            20                  25                  30          


Asp Gly Tyr Thr Phe Leu Glu Trp Tyr Leu Gln Lys Pro Gly Gln Ser 
        35                  40                  45              


Pro Gln Leu Leu Ile Tyr Glu Val Ser Asn Arg Phe Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Phe Gln Ala 
                85                  90                  95      


Thr His Asp Pro Leu Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         


Arg 
    


<210>  55
<211>  121
<212>  PRT
<213>  Artificial

<220>
<223>  VH 8D1

<400>  55

Glu Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Val Lys Pro Gly Thr 
1               5                   10                  15      


Ser Val Lys Met Ser Cys Lys Thr Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Val Met His Trp Val Lys Gln Lys Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Tyr Ile Ile Pro Tyr Asn Asp Asn Thr Lys Tyr Asn Glu Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Leu Thr Ser Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Arg Asn Glu Tyr Tyr Gly Ser Ser Phe Phe Asp Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Thr Leu Thr Val Ser Ser 
        115                 120     


<210>  56
<211>  108
<212>  PRT
<213>  Artificial

<220>
<223>  VL 8D1

<400>  56

Asp Ile Gln Met Thr Gln Ser Pro Ala Ser Leu Ser Ala Ser Leu Glu 
1               5                   10                  15      


Glu Ile Val Thr Ile Thr Cys Gln Ala Ser Gln Asp Ile Asp Asn Tyr 
            20                  25                  30          


Leu Ala Trp Tyr His Gln Lys Pro Gly Lys Ser Pro Arg Leu Leu Ile 
        35                  40                  45              


Tyr Gly Ala Thr Asn Leu Ala Asp Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Arg Ser Gly Thr Gln Phe Ser Leu Lys Ile Asn Arg Leu Gln Ile 
65                  70                  75                  80  


Glu Asp Leu Gly Ile Tyr Tyr Cys Leu Gln Gly Tyr Ile Pro Pro Arg 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Glu Leu Lys Arg 
            100                 105             


<210>  57
<211>  5
<212>  PRT
<213>  Artificial

<220>
<223>  VH 5F9 CDR H1

<400>  57

Asn Tyr Gly Met Asn 
1               5   


<210>  58
<211>  17
<212>  PRT
<213>  Artificial

<220>
<223>  VH 5F9 CDR-H2

<400>  58

Met Ile Tyr Tyr Asp Ser Ser Glu Lys His Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  59
<211>  6
<212>  PRT
<213>  Artificial

<220>
<223>  VH 5F9 CDR-H3

<400>  59

Gly Thr Thr Pro Asp Tyr 
1               5       


<210>  60
<211>  16
<212>  PRT
<213>  Artificial

<220>
<223>  VL 5F9 CDR-L1

<400>  60

Arg Ser Ser Gln Ser Leu Glu Tyr Ser Asp Gly Tyr Thr Phe Leu Glu 
1               5                   10                  15      


<210>  61
<211>  7
<212>  PRT
<213>  Artificial

<220>
<223>  VL 5F9 CDR-L2

<400>  61

Glu Val Ser Asn Arg Phe Ser 
1               5           


<210>  62
<211>  9
<212>  PRT
<213>  Artificial

<220>
<223>  VL 5F9 CDR-L3

<400>  62

Phe Gln Ala Thr His Asp Pro Leu Thr 
1               5                   


<210>  63
<211>  5
<212>  PRT
<213>  Artificial

<220>
<223>  VH 8D1 CDR-H1

<400>  63

Ser Tyr Val Met His 
1               5   


<210>  64
<211>  17
<212>  PRT
<213>  Artificial

<220>
<223>  VH 8D1 CDR-H2

<400>  64

Tyr Ile Ile Pro Tyr Asn Asp Asn Thr Lys Tyr Asn Glu Lys Phe Lys 
1               5                   10                  15      


Gly 
    


<210>  65
<211>  14
<212>  PRT
<213>  Artificial

<220>
<223>  VH 8D1 CDR-H3

<400>  65

Ala Arg Arg Asn Glu Tyr Tyr Gly Ser Ser Phe Phe Asp Tyr 
1               5                   10                  


<210>  66
<211>  11
<212>  PRT
<213>  Artificial

<220>
<223>  VL 8D1 CDR-L1

<400>  66

Gln Ala Ser Gln Asp Ile Asp Asn Tyr Leu Ala 
1               5                   10      


<210>  67
<211>  7
<212>  PRT
<213>  Artificial

<220>
<223>  VL 8D1 CDR-L2

<400>  67

Gly Ala Thr Asn Leu Ala Asp 
1               5           


<210>  68
<211>  9
<212>  PRT
<213>  Artificial

<220>
<223>  VL 8D1 CDR-L3

<400>  68

Leu Gln Gly Tyr Ile Pro Pro Arg Thr 
1               5                   


