                         SEQUENCE LISTING

<110>  Cedars-Sinai Medical Center
       Kaye, Jonathan
 
<120>  TOX3 AS A BIOMARKER FOR BREAST CANCER

<130>  67789-255WO0

<150>  US 61/266,918
<151>  2009-12-04

<160>  4     

<170>  PatentIn version 3.5

<210>  1
<211>  589
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1

Met Asp Val Arg Phe Tyr Pro Ala Ala Ala Gly Asp Pro Ala Ser Leu 
1               5                   10                  15      


Asp Phe Ala Gln Cys Leu Gly Tyr Tyr Gly Tyr Ser Lys Phe Gly Asn 
            20                  25                  30          


Asn Asn Asn Tyr Met Asn Met Ala Glu Ala Asn Asn Ala Phe Phe Ala 
        35                  40                  45              


Ala Ser Glu Gln Thr Phe His Thr Pro Ser Leu Gly Asp Glu Glu Phe 
    50                  55                  60                  


Glu Ile Pro Pro Ile Thr Pro Pro Pro Glu Ser Asp Pro Ala Leu Gly 
65                  70                  75                  80  


Met Pro Asp Val Leu Leu Pro Phe Gln Ala Leu Ser Asp Pro Leu Pro 
                85                  90                  95      


Ser Gln Gly Ser Glu Phe Thr Pro Gln Phe Pro Pro Gln Ser Leu Asp 
            100                 105                 110         


Leu Pro Ser Ile Thr Ile Ser Arg Asn Leu Val Glu Gln Asp Gly Val 
        115                 120                 125             


Leu His Ser Ser Gly Leu His Met Asp Gln Ser His Thr Gln Val Ser 
    130                 135                 140                 


Gln Tyr Arg Gln Asp Pro Ser Leu Ile Met Arg Ser Ile Val His Met 
145                 150                 155                 160 


Thr Asp Ala Ala Arg Ser Gly Val Met Pro Pro Ala Gln Leu Thr Thr 
                165                 170                 175     


Ile Asn Gln Ser Gln Leu Ser Ala Gln Leu Gly Leu Asn Leu Gly Gly 
            180                 185                 190         


Ala Ser Met Pro His Thr Ser Pro Ser Pro Pro Ala Ser Lys Ser Ala 
        195                 200                 205             


Thr Pro Ser Pro Ser Ser Ser Ile Asn Glu Glu Asp Ala Asp Glu Ala 
    210                 215                 220                 


Asn Arg Ala Ile Gly Glu Lys Arg Ala Ala Pro Asp Ser Gly Lys Lys 
225                 230                 235                 240 


Pro Lys Thr Pro Lys Lys Lys Lys Lys Lys Asp Pro Asn Glu Pro Gln 
                245                 250                 255     


Lys Pro Val Ser Ala Tyr Ala Leu Phe Phe Arg Asp Thr Gln Ala Ala 
            260                 265                 270         


Ile Lys Gly Gln Asn Pro Asn Ala Thr Phe Gly Glu Val Ser Lys Ile 
        275                 280                 285             


Val Ala Ser Met Trp Asp Ser Leu Gly Glu Glu Gln Lys Gln Val Tyr 
    290                 295                 300                 


Lys Arg Lys Thr Glu Ala Ala Lys Lys Glu Tyr Leu Lys Ala Leu Ala 
305                 310                 315                 320 


Ala Tyr Arg Ala Ser Leu Val Ser Lys Ala Ala Ala Glu Ser Ala Glu 
                325                 330                 335     


Ala Gln Thr Ile Arg Ser Val Gln Gln Thr Leu Ala Ser Thr Asn Leu 
            340                 345                 350         


Thr Ser Ser Leu Leu Leu Asn Thr Pro Leu Ser Gln His Gly Thr Val 
        355                 360                 365             


Ser Ala Ser Pro Gln Thr Leu Gln Gln Ser Leu Pro Arg Ser Ile Ala 
    370                 375                 380                 


Pro Lys Pro Leu Thr Met Arg Leu Pro Met Asn Gln Ile Val Thr Ser 
385                 390                 395                 400 


Val Thr Ile Ala Ala Asn Met Pro Ser Asn Ile Gly Ala Pro Leu Ile 
                405                 410                 415     


Ser Ser Met Gly Thr Thr Met Val Gly Ser Ala Pro Ser Thr Gln Val 
            420                 425                 430         


Ser Pro Ser Val Gln Thr Gln Gln His Gln Met Gln Leu Gln Gln Gln 
        435                 440                 445             


Gln Gln Gln Gln Gln Gln Gln Met Gln Gln Met Gln Gln Gln Gln Leu 
    450                 455                 460                 


Gln Gln His Gln Met His Gln Gln Ile Gln Gln Gln Met Gln Gln Gln 
465                 470                 475                 480 


His Phe Gln His His Met Gln Gln His Leu Gln Gln Gln Gln Gln His 
                485                 490                 495     


Leu Gln Gln Gln Ile Asn Gln Gln Gln Leu Gln Gln Gln Leu Gln Gln 
            500                 505                 510         


Arg Leu Gln Leu Gln Gln Leu Gln His Met Gln His Gln Ser Gln Pro 
        515                 520                 525             


Ser Pro Arg Gln His Ser Pro Val Ala Ser Gln Ile Thr Ser Pro Ile 
    530                 535                 540                 


Pro Ala Ile Gly Ser Pro Gln Pro Ala Ser Gln Gln His Gln Ser Gln 
545                 550                 555                 560 


Ile Gln Ser Gln Thr Gln Thr Gln Val Leu Ser Gln Ala Ile Pro Thr 
                565                 570                 575     


Ile Cys Glu Ser Asn Cys Leu Met Asn Pro Gly Thr Tyr 
            580                 585                 


<210>  2
<211>  238
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2

Met Asp Val Arg Phe Tyr Pro Ala Ala Ala Gly Asp Pro Ala Ser Leu 
1               5                   10                  15      


Asp Phe Ala Gln Cys Leu Gly Tyr Tyr Gly Tyr Ser Lys Phe Gly Asn 
            20                  25                  30          


Asn Asn Asn Tyr Met Asn Met Ala Glu Ala Asn Asn Ala Phe Phe Ala 
        35                  40                  45              


Ala Ser Glu Gln Thr Phe His Thr Pro Ser Leu Gly Asp Glu Glu Phe 
    50                  55                  60                  


Glu Ile Pro Pro Ile Thr Pro Pro Pro Glu Ser Asp Pro Ala Leu Gly 
65                  70                  75                  80  


Met Pro Asp Val Leu Leu Pro Phe Gln Ala Leu Ser Asp Pro Leu Pro 
                85                  90                  95      


Ser Gln Gly Ser Glu Phe Thr Pro Gln Phe Pro Pro Gln Ser Leu Asp 
            100                 105                 110         


Leu Pro Ser Ile Thr Ile Ser Arg Asn Leu Val Glu Gln Asp Gly Val 
        115                 120                 125             


Leu His Ser Ser Gly Leu His Met Asp Gln Ser His Thr Gln Val Ser 
    130                 135                 140                 


Gln Tyr Arg Gln Asp Pro Ser Leu Ile Met Arg Ser Ile Val His Met 
145                 150                 155                 160 


Thr Asp Ala Ala Arg Ser Gly Val Met Pro Pro Ala Gln Leu Thr Thr 
                165                 170                 175     


Ile Asn Gln Ser Gln Leu Ser Ala Gln Leu Gly Leu Asn Leu Gly Gly 
            180                 185                 190         


Ala Ser Met Pro His Thr Ser Pro Ser Pro Pro Ala Ser Lys Ser Ala 
        195                 200                 205             


Thr Pro Ser Pro Ser Ser Ser Ile Asn Glu Glu Asp Ala Asp Glu Ala 
    210                 215                 220                 


Asn Arg Ala Ile Gly Glu Lys Arg Ala Ala Pro Asp Ser Gly 
225                 230                 235             


<210>  3
<211>  1734
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  3
atggatgtga ggttctaccc cgcggcggcc ggggatcccg ccggcctgga cttcgcgcag       60

tgcctggggt actacggcta cagcaagttg ggaaataata actacatgaa catggctgag      120

gcaaacaacg ccttctttgc tgccagtgag cagacattcc acacgccaag ccttggggat      180

gaagagtttg aaattccgcc gatcacgcct cctccagagt cagaccccac cctgggcatg      240

cccgatgtac tgctaccctt tcagacactc agcgatccgt tgccttccca gggaaatgag      300

ttcacacccc agtttccccc tcagagcctg gatcttcctt ccatcacaat ctcaaggaat      360

ctggtggagc aagatggtgt gcttcatagc aacgggctgc atatggatca gagccacaca      420

caagtgtcgc agtaccgcca ggatccttct ttggtcatga ggtcaattgt ccacatgaca      480

gatgctgctc gctctgggat catgcctcct gcccaactga ccaccatcaa ccagtctcag      540

ctcagtgcac agttgggctt gaatctggga ggagccagtg tgccccacac gtctccttca      600

cctccagcaa gcaaatcagc cactccctcc ccttccagct ctatcaatga agaggatgct      660

gatgaaacaa acagagccgt tggagagaaa agaacagccc cagattctgg caagaagccc      720

aagactccaa agaaaaagaa aaagaaagat cccaacgagc ctcagaagcc agtgtcagca      780

tacgccctgt ttttcagaga tacacaggct gcaattaaag gtcaaaaccc caatgcgacc      840

tttggagaag tctcaaaaat tgtagcatct atgtgggaca gccttggaga ggagcaaaag      900

caggtatata aaaggaaaac agaagctgcc aagaaagaat atttgaaggc cctggctgcc      960

taccgggcca gcctcgtttc taaggctgct gctgagtccg cagaagccca gactatccgc     1020

tctgtccagc agactctggc atcaaccaac ctgacatcct ctctccttct gaacacgtca     1080

ctgtctcaac atgggacagt cccggcttca cctcagactc tcccgcagtc actccctagg     1140

tcgattgccc ccaaaccctt aaccatgaga ctacccatga gccagattgt cacatcagtc     1200

accattgcag ccaacatgcc ctcgaacatt ggggctccac ttatcagctc catgggaacg     1260

accatggttg gctcagtatc ctccacgcag gtgagccctt cggtacaaac ccagcaacat     1320

cagctgcagc tgcagcagca gcaacaacag cagcagcagc agatgcagca gatgcaacat     1380

cagcagctgc agcagcacca gatgcatcag cagattcagc agcagatgca gcagcagcat     1440

ttccagcacc acatgcaaca gcacctgcag cagcagcaac agcagcacct ccagcagcag     1500

atcagccaac agcagctgca gcagcagctg cagcagcatc tccagctgca gcagcagctg     1560

cagcacatgc agcaccagtc tcagccttct ccccggcagc actcgcccgt cacctcacag     1620

atcacgtccc ccatccccgc cattggcagc ccccagccag cctctcagca gcaccagcct     1680

caaatccagt cgcagacaca gactcaagtg ttaccgcagg tcagtatttt ttaa           1734


<210>  4
<211>  2849
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  4
gcggccgcgg ctcccgagct cctcgggctc tgggtcccgg cgcccctccg gccgcgagtc       60

ccacgcgcca cccccgggcg ccctcgacgg tggatctagc ggcggcgagg aggcgggtcc      120

cggccccggc gaaccccagt cccggccccc ggccccgggc ccagcttcgg catggatgtg      180

aggttctacc ccgcggcggc cggggaccct gccagcctgg acttcgcgca gtgcctgggg      240

tactacggct acagcaagtt tggaaataat aataactata tgaatatggc tgaggcgaac      300

aatgcgttct tcgctgccag tgagcagaca ttccacacac caagccttgg ggacgaggaa      360

ttcgaaattc caccaatcac gcctcctcca gagtcagacc ctgccctagg catgccggat      420

gtactgctac cctttcaagc cctcagcgat ccattgcctt cccagggaag tgaattcaca      480

ccccagtttc cccctcaaag cctggacctc ccttccatta caatctcaag aaatctcgtg      540

gaacaagatg gcgtgcttca tagcagtggg ttgcatatgg atcagagcca cacacaagtg      600

tcccagtacc ggcaggatcc ctccctgatc atgcggtcca tcgtccacat gaccgatgct      660

gcgcgttctg gggtcatgcc tcctgcccag ctcaccacca tcaaccagtc tcagctcagc      720

gcccagttgg ggttgaattt gggaggtgcc agtatgcctc acacatctcc ttcacctcca      780

gcaagcaaat cagccactcc ctccccttcc agctccatca atgaagagga tgctgatgaa      840

gccaacagag ccattggaga gaaaagagct gctccagact ctggcaagaa gcccaagact      900

ccaaagaaaa agaaaaagaa agatcccaat gagccacaga agccagtgtc agcatatgcc      960

ctgtttttca gagacacaca ggctgcaatt aaaggtcaaa accccaatgc aacctttgga     1020

gaggtctcaa aaattgtagc atctatgtgg gacagccttg gagaagaaca aaagcaggta     1080

tataaaagga aaacagaagc tgccaaaaaa gaatacctga aggccctggc ggcatacagg     1140

gccagcctcg tttctaaggc tgctgctgag tcagcagaag cccagaccat ccgttctgtt     1200

cagcagaccc tggcgtcgac caatctaaca tcctctctcc ttctcaacac tccactgtct     1260

caacatggaa cagtgtcagc atcacctcag actctccagc aatccctccc taggtcaatc     1320

gctcccaaac ccttaaccat gagactcccc atgaaccaga ttgtcacatc agtcaccatt     1380

gcagccaaca tgccctcgaa cattggggct ccactgataa gctccatggg aacgaccatg     1440

gttggctcag caccctccac ccaagtgagt ccttcggtgc aaacccagca gcatcagatg     1500

caattgcagc agcagcagca gcagcaacaa caacagatgc aacagatgca gcagcagcaa     1560

ctccagcagc accaaatgca tcagcaaatc cagcagcaga tgcagcagca gcatttccag     1620

caccacatgc agcagcacct gcagcagcag cagcagcatc tccagcagca aattaatcaa     1680

cagcagctgc agcagcagct gcagcagcgc ctccagctgc agcagctgca acacatgcag     1740

caccagtctc agccttctcc tcggcagcac tcccctgtcg cctctcagat aacatccccc     1800

atccctgcca tcgggagccc ccagccagcc tctcagcagc accagtcgca aatacagtct     1860

cagacacaga ctcaagtatt atcgcaggct atacctacaa tatgtgaatc aaactgttta     1920

atgaatcctg ggacatactg atgactataa actggcctct ctgagtcata gaaaaatggc     1980

cttatttctc cagaagtgag taaaccacac ttccaggcta tctgaactcc tgaagcccta     2040

aaaataaaaa gcacagttgt aactacctga aatatgaaga tccagtttca tacaaacatt     2100

tgtatgacgt gaatagttga tggcattttt ttgtcatgaa aaaaataatg taaatcacag     2160

acttttgcca aagctcttat tttttttcct aaatctctcc agaaaaaaaa tgcaagtgac     2220

taaattcaat tattgactaa tttccacttt ttatccatga cttctccaaa tcaaaccaca     2280

gtatatgttg taacaatatc tatgaccact gttagcccat tatattcatt ccaattagaa     2340

gaaatgtgaa tactatattc cgtgttttga gtgacaagtt tcgaaaaata aaaacactgt     2400

atttttaaaa gggaaatgca cttaaatgaa aacagttatt acaaaagtta agatttaaaa     2460

agaaaaagca agagttttta ttatgatgta ataccagtag aatatttaaa aggcacacca     2520

catctgaata atcaatgtaa atattttctt tcaaagttgt aagttttcat atcatgtgct     2580

gtaaagtttt cctaaatgag gctttaacgt aaacactggt gacataaacc attcattgct     2640

acgttgctta ttgtgttttt atgctgtttt atactttttt atgagttatg atagcagcaa     2700

ttaagttgtt tgtattttgc ttaactaaaa caaaaatgct tttatcttgc tatagaataa     2760

acacatttca gtaaaaactg tggactgtat tttgatgcaa caacaaagaa actgttcact     2820

tttcaaataa aatgatatgt cagatttca                                       2849


