                         SEQUENCE LISTING

<110>  SHIRE HUMAN GENETIC THERAPIES
 
<120>  DELIVERY OF MRNA FOR THE AUGMENTATION OF PROTEINS AND ENZYMES IN 
       HUMAN GENETIC DISEASES

<130>  SHIR-004-WO1

<140>  PCT/US2010/058457
<141>  2010-11-30

<150>  61/265,653
<151>  2009-12-01

<160>  3     

<170>  PatentIn version 3.5

<210>  1
<211>  1672
<212>  RNA
<213>  Artificial

<220>
<223>  CO-FF Luciferase mRNA

<400>  1
gggauccuac cauggaagau gccaaaaaca uuaagaaggg cccagcgcca uucuacccac       60

ucgaagacgg gaccgccggc gagcagcugc acaaagccau gaagcgcuac gcccuggugc      120

ccggcaccau cgccuuuacc gacgcacaua ucgaggugga cauuaccuac gccgaguacu      180

ucgagaugag cguucggcug gcagaagcua ugaagcgcua ugggcugaau acaaaccauc      240

ggaucguggu gugcagcgag aauagcuugc aguucuucau gcccguguug ggugcccugu      300

ucaucggugu ggcuguggcc ccagcuaacg acaucuacaa cgagcgcgag cugcugaaca      360

gcaugggcau cagccagccc accgucguau ucgugagcaa gaaagggcug caaaagaucc      420

ucaacgugca aaagaagcua ccgaucauac aaaagaucau caucauggau agcaagaccg      480

acuaccaggg cuuccaaagc auguacaccu ucgugacuuc ccauuugcca cccggcuuca      540

acgaguacga cuucgugccc gagagcuucg accgggacaa aaccaucgcc cugaucauga      600

acaguagugg caguaccgga uugcccaagg gcguagcccu accgcaccgc accgcuugug      660

uccgauucag ucaugcccgc gaccccaucu ucggcaacca gaucaucccc gacaccgcua      720

uccucagcgu ggugccauuu caccacggcu ucggcauguu caccacgcug ggcuacuuga      780

ucugcggcuu ucgggucgug cucauguacc gcuucgagga ggagcuauuc uugcgcagcu      840

ugcaagacua uaagauucaa ucugcccugc uggugcccac acuauuuagc uucuucgcua      900

agagcacucu caucgacaag uacgaccuaa gcaacuugca cgagaucgcc agcggcgggg      960

cgccgcucag caaggaggua ggugaggccg uggccaaacg cuuccaccua ccaggcaucc     1020

gccagggcua cggccugaca gaaacaacca gcgccauucu gaucaccccc gaaggggacg     1080

acaagccugg cgcaguaggc aagguggugc ccuucuucga ggcuaaggug guggacuugg     1140

acaccgguaa gacacugggu gugaaccagc gcggcgagcu gugcguccgu ggccccauga     1200

ucaugagcgg cuacguuaac aaccccgagg cuacaaacgc ucucaucgac aaggacggcu     1260

ggcugcacag cggcgacauc gccuacuggg acgaggacga gcacuucuuc aucguggacc     1320

ggcugaagag ccugaucaaa uacaagggcu accagguagc cccagccgaa cuggagagca     1380

uccugcugca acaccccaac aucuucgacg ccggggucgc cggccugccc gacgacgaug     1440

ccggcgagcu gcccgccgca gucgucgugc uggaacacgg uaaaaccaug accgagaagg     1500

agaucgugga cuauguggcc agccagguua caaccgccaa gaagcugcgc ggugguguug     1560

uguucgugga cgaggugccu aaaggacuga ccggcaaguu ggacgcccgc aagauccgcg     1620

agauucucau uaaggccaag aagggcggca agaucgccgu guaauuugaa uu             1672


<210>  2
<211>  157
<212>  RNA
<213>  Artificial

<220>
<223>  5' CMV Sequence

<400>  2
uaauacgacu cacuauagga cagaucgccu ggagacgcca uccacgcugu uuugaccucc       60

auagaagaca ccgggaccga uccagccucc gcggccggga acggugcauu ggaacgcgga      120

uuccccgugc caagagugac ucaccguccu ugacacg                               157


<210>  3
<211>  100
<212>  RNA
<213>  Artificial

<220>
<223>  3' hGH Sequence

<400>  3
cggguggcau cccugugacc ccuccccagu gccucuccug gcccuggaag uugccacucc       60

agugcccacc agccuugucc uaauaaaauu aaguugcauc                            100


