                         SEQUENCE LISTING

<110>  ASSISTANCE PUBLIQUE - HOPITAUX DE PARIS
 
<120>  METHODE DE DETECTION D'UNE POLYGLOBULIE CHEZ UN CHIEN

<130>  BRV 22 - WO

<150>  EP09178051.0
<151>  2009-12-04

<160>  4     

<170>  PatentIn version 3.3

<210>  1
<211>  1132
<212>  PRT
<213>  Canis familiaris

<400>  1

Met Gly Met Ala Cys Leu Thr Met Thr Glu Met Glu Gly Thr Ser Glu 
1               5                   10                  15      


Ser Pro Ile His Gln Asn Gly Asp Ile Pro Gly Asn Ala Asn Ser Val 
            20                  25                  30          


Lys Gln Ile Asp Pro Leu Leu Gln Val Tyr Leu Tyr His Ser Leu Glu 
        35                  40                  45              


Lys Ala Glu Glu Glu Tyr Leu Lys Phe Pro Thr Gly Glu Tyr Val Ala 
    50                  55                  60                  


Glu Glu Ile Cys Val Ala Ala Ser Lys Ala Cys Gly Ile Thr Pro Val 
65                  70                  75                  80  


Tyr His Ser Met Phe Ala Leu Met Ser Glu Thr Glu Arg Ile Trp Tyr 
                85                  90                  95      


Pro Pro Asn His Val Phe His Ile Asp Glu Ser Thr Lys His Asn Val 
            100                 105                 110         


Leu Tyr Arg Ile Arg Phe Tyr Phe Pro Tyr Trp Tyr Cys Asn Gly Ser 
        115                 120                 125             


Asn Arg Thr Tyr Arg His Gly Ile Ser Arg Gly Ala Glu Ala Pro Leu 
    130                 135                 140                 


Leu Asp Asp Phe Val Met Ala Tyr Leu Phe Ala Gln Trp Arg His Asp 
145                 150                 155                 160 


Phe Leu His Gly Trp Ile Lys Ile Pro Val Thr His Glu Thr Gln Glu 
                165                 170                 175     


Glu Cys Leu Gly Met Ala Val Leu Asp Met Met Arg Leu Ala Lys Glu 
            180                 185                 190         


Lys Asp Gln Thr Pro Leu Asp Ile Tyr Ser Ser Ile Ser Tyr Lys Thr 
        195                 200                 205             


Phe Leu Pro Lys Cys Val Arg Ala Lys Ile Gln Asp Tyr His Ile Leu 
    210                 215                 220                 


Thr Arg Lys Arg Ile Arg Tyr Arg Phe Arg Arg Phe Ile Glu Gln Phe 
225                 230                 235                 240 


Ser His Cys Lys Ala Thr Ala Arg Asn Leu Lys Leu Lys Tyr Leu Ile 
                245                 250                 255     


Asn Leu Glu Thr Leu Gln Ser Ala Phe Tyr Thr Glu Gln Phe Glu Val 
            260                 265                 270         


Lys Glu Pro Gly Arg Gly Pro Ser Gly Glu Glu Ile Phe Ala Thr Ile 
        275                 280                 285             


Ile Ile Thr Gly Asn Gly Gly Ile Gln Trp Ser Arg Gly Lys Arg Lys 
    290                 295                 300                 


Glu Ser Glu Thr Leu Thr Glu Gln Asp Leu Gln Leu Tyr Cys Asp Phe 
305                 310                 315                 320 


Pro Asp Ile Ile Asp Val Thr Ile Lys Gln Ala Ser Gln Glu Gly Ser 
                325                 330                 335     


Asn Glu Ser Arg Ile Val Thr Ile His Lys Gln Asp Gly Lys Asn Leu 
            340                 345                 350         


Glu Ile Glu Leu Ser Ser Leu Arg Glu Ala Leu Ser Phe Val Ser Leu 
        355                 360                 365             


Ile Asp Gly Tyr Tyr Arg Leu Thr Ala Asp Ala His His Tyr Leu Cys 
    370                 375                 380                 


Lys Glu Val Ala Pro Pro Met Val Leu Glu Asn Ile Gln Ser Asn Cys 
385                 390                 395                 400 


His Gly Pro Ile Leu Met Asp Phe Ala Ile Ser Lys Leu Lys Lys Ala 
                405                 410                 415     


Gly Asn Gln Thr Gly Leu Tyr Val Leu Arg Cys Ser Pro Lys Asp Phe 
            420                 425                 430         


Asn Lys Tyr Phe Leu Thr Phe Ala Ile Glu Arg Glu Asn Val Ile Glu 
        435                 440                 445             


Tyr Lys His Cys Leu Ile Thr Lys Asn Glu Asn Gly Glu Tyr Asn Leu 
    450                 455                 460                 


Ser Gly Thr Lys Lys Ser Phe Arg Asn Leu Lys Asp Leu Leu Asn Cys 
465                 470                 475                 480 


Tyr His Met Glu Thr Val Arg Ser Asp Ser Ile Ile Phe Gln Phe Thr 
                485                 490                 495     


Lys Cys Cys Pro Pro Lys Leu Lys Asp Lys Ser Asn Leu Leu Val Phe 
            500                 505                 510         


Arg Thr Asn Gly Val Ser Asp Val Pro Thr Ser Pro Thr Leu Gln Arg 
        515                 520                 525             


His Asn Asn Val Asn Gln Met Val Phe His Lys Ile Arg Asn Glu Asp 
    530                 535                 540                 


Leu Met Phe Asn Glu Ser Leu Gly Gln Gly Thr Phe Thr Lys Ile Phe 
545                 550                 555                 560 


Lys Gly Val Arg Arg Glu Val Gly Asp Tyr Gly Gln Leu His Glu Thr 
                565                 570                 575     


Glu Val Leu Leu Lys Val Leu Asp Lys Ala His Arg Asn Tyr Ser Glu 
            580                 585                 590         


Ser Phe Phe Glu Ala Ala Ser Met Met Ser Gln Leu Ser His Lys His 
        595                 600                 605             


Leu Val Leu Asn Tyr Gly Val Cys Val Cys Gly Glu Glu Asn Ile Leu 
    610                 615                 620                 


Val Gln Glu Phe Val Lys Phe Gly Ser Leu Asp Thr Tyr Leu Lys Lys 
625                 630                 635                 640 


Asn Lys Asn Ser Ile Asn Ile Phe Trp Lys Leu Glu Val Ala Lys Gln 
                645                 650                 655     


Leu Ala Trp Ala Met His Phe Leu Glu Glu Lys Ala Leu Ile His Gly 
            660                 665                 670         


Asn Val Cys Ala Lys Asn Ile Leu Leu Ile Arg Glu Glu Asp Arg Lys 
        675                 680                 685             


Thr Gly Asn Pro Pro Phe Ile Lys Leu Ser Asp Pro Gly Ile Ser Ile 
    690                 695                 700                 


Thr Val Leu Pro Lys Asp Ile Leu Gln Glu Arg Ile Pro Trp Val Pro 
705                 710                 715                 720 


Pro Glu Cys Ile Glu Asn Pro Lys Asn Leu Asn Leu Ala Thr Asp Lys 
                725                 730                 735     


Trp Ser Phe Gly Thr Thr Leu Trp Glu Ile Cys Ser Gly Gly Asp Lys 
            740                 745                 750         


Pro Leu Ser Ala Leu Asp Ser Gln Arg Lys Leu Gln Phe Tyr Glu Asp 
        755                 760                 765             


Arg His Gln Leu Pro Ala Pro Lys Trp Thr Glu Leu Ala Asn Leu Ile 
    770                 775                 780                 


Asn Asn Cys Met Asp Tyr Glu Pro Asp Phe Arg Pro Ser Phe Arg Ala 
785                 790                 795                 800 


Ile Ile Arg Asp Leu Asn Ser Leu Phe Thr Pro Asp Tyr Glu Leu Leu 
                805                 810                 815     


Thr Glu Asn Asp Met Leu Pro Asn Met Arg Ile Gly Ala Leu Gly Phe 
            820                 825                 830         


Pro Gly Ala Phe Glu Asp Gln Asp Pro Thr Gln Phe Glu Glu Arg His 
        835                 840                 845             


Leu Lys Phe Leu Gln Gln Leu Gly Lys Gly Asn Phe Gly Ser Val Glu 
    850                 855                 860                 


Met Cys Arg Tyr Asp Pro Leu Gln Asp Asn Thr Gly Glu Val Val Ala 
865                 870                 875                 880 


Val Lys Lys Leu Gln His Ser Thr Glu Glu His Leu Arg Asp Phe Glu 
                885                 890                 895     


Arg Glu Ile Glu Ile Leu Lys Ser Leu Gln His Asp Asn Ile Val Lys 
            900                 905                 910         


Tyr Lys Gly Val Cys Tyr Ser Ala Gly Arg Arg Asn Leu Arg Leu Ile 
        915                 920                 925             


Met Glu Tyr Leu Pro Tyr Gly Ser Leu Arg Asp Tyr Leu Gln Lys His 
    930                 935                 940                 


Lys Glu Arg Ile Asp His Lys Lys Leu Leu Gln Tyr Thr Ser Gln Ile 
945                 950                 955                 960 


Cys Lys Gly Met Glu Tyr Leu Gly Thr Lys Arg Tyr Ile His Arg Asp 
                965                 970                 975     


Leu Ala Thr Arg Asn Ile Leu Val Glu Asn Glu Asn Arg Val Lys Ile 
            980                 985                 990         


Gly Asp Phe Gly Leu Thr Lys Val  Leu Pro Gln Asp Lys  Glu Tyr Tyr 
        995                 1000                 1005             


Lys Val  Lys Glu Pro Gly Glu  Ser Pro Ile Phe Trp  Tyr Ala Pro 
    1010                 1015                 1020             


Glu Ser  Leu Thr Glu Ser Lys  Phe Ser Val Ala Ser  Asp Val Trp 
    1025                 1030                 1035             


Ser Phe  Gly Val Val Leu Tyr  Glu Leu Phe Thr Tyr  Ile Glu Lys 
    1040                 1045                 1050             


Ser Lys  Ser Pro Pro Ala Glu  Phe Met Arg Met Ile  Gly Asn Asp 
    1055                 1060                 1065             


Lys Gln  Gly Gln Met Ile Val  Phe His Leu Ile Glu  Leu Leu Lys 
    1070                 1075                 1080             


Asn Asn  Gly Arg Leu Pro Arg  Pro Asp Gly Cys Pro  Asp Glu Ile 
    1085                 1090                 1095             


Tyr Leu  Ile Met Thr Glu Cys  Trp Asn Asn Asn Val  Asn Gln Arg 
    1100                 1105                 1110             


Pro Ser  Phe Arg Asp Leu Ala  Leu Arg Val Asp Gln  Ile Arg Asp 
    1115                 1120                 1125             


Asn Met  Ala Gly 
    1130         


<210>  2
<211>  3399
<212>  DNA
<213>  Canis familiaris

<400>  2
atgggaatgg cttgccttac aatgacagaa atggaaggaa catccgaatc tcctatacat     60

cagaatggtg atattcctgg aaatgctaat tctgtgaagc aaatagaccc actcctacag    120

gtgtatcttt atcattctct tgagaaagct gaagaagaat atctgaagtt tccaactggg    180

gagtatgttg cagaagaaat ttgtgttgct gcttctaaag cttgtggaat cacacctgtg    240

tatcatagta tgtttgcttt aatgagtgaa acagaaagga tctggtatcc acccaaccac    300

gtcttccata ttgatgaatc aaccaagcac aatgtactct acagaataag attttacttc    360

ccttactggt attgtaacgg cagcaacaga acctatcggc acggaatatc tcgaggtgct    420

gaagctcctc ttcttgacga ctttgtcatg gcttatcttt ttgctcagtg gcggcatgat    480

tttttacatg gatggataaa aatacccgtg actcatgaaa cacaggaaga atgtcttgga    540

atggctgtgc tagatatgat gagactagcc aaagaaaagg atcaaacccc actggatatc    600

tatagctcta tcagctacaa gacattctta cccaaatgtg ttcgagcaaa gattcaagac    660

tatcatattt tgacaaggaa acgaataagg tacagatttc gcagatttat tgagcagttc    720

agccattgca aagccactgc cagaaacttg aaacttaagt accttataaa tctggaaact    780

cttcagtctg ccttctacac agagcaattt gaagtaaaag aacctggaag aggtccttca    840

ggtgaggaga tttttgcaac cattataata actggaaacg gtggaattca gtggtcaaga    900

gggaaacgta aagaaagtga gacactgaca gaacaggatt tacagttata ttgtgacttt    960

cctgatatta ttgatgttac tattaagcaa gcaagccaag aaggctcaaa tgaaagtaga   1020

attgtaacta tccataagca agatggtaaa aatctggaaa ttgaacttag ctcattaaga   1080

gaagctttgt cctttgtgtc attaattgat ggctattata gattaactgc agatgcacat   1140

cattacctct gtaaagaagt agcacctcca atggtccttg aaaatataca aagcaactgt   1200

catggcccaa ttttaatgga ttttgctatc agtaaactga agaaagcagg taatcagact   1260

ggactctatg tacttcgatg cagccctaag gactttaata aatatttcct gacttttgcc   1320

attgagcgag aaaatgtcat cgaatataag cactgtttga ttacaaaaaa tgaaaatgga   1380

gaatacaacc tcagtgggac caagaagagc ttccgtaatc ttaaagatct tttgaactgc   1440

taccacatgg agactgttcg ctcagacagc ataattttcc agtttaccaa atgctgtccc   1500

ccaaaattga aagataagtc aaaccttcta gtcttcagaa ccaatggcgt ttctgatgta   1560

ccaacatcac caacattaca gaggcataat aatgtgaacc aaatggtgtt ccacaaaatc   1620

agaaatgaag atttgatgtt taacgaaagt cttggccaag gcacttttac aaaaattttt   1680

aaaggtgtga gaagagaagt aggagactat ggtcaactgc atgaaacaga agttctttta   1740

aaagttcttg ataaagcaca cagaaattat tcagagtctt tctttgaagc agccagcatg   1800

atgagccagc tttctcataa gcatctggtt ttaaattatg gagtatgtgt ctgtggagag   1860

gagaatattc tggttcagga atttgtaaaa tttggatcat tagatacata tctgaaaaag   1920

aataagaatt ctataaatat attttggaaa cttgaagtgg ctaaacagtt ggcatgggca   1980

atgcattttc tagaagagaa agcacttatt catggaaatg tgtgtgccaa aaatattctg   2040

cttatcagag aagaagacag gaagacagga aatcctcctt tcatcaaact tagtgatcct   2100

ggcattagta ttacagtttt gccaaaggac attcttcagg agagaatacc atgggtacca   2160

cctgaatgca ttgaaaatcc taaaaatcta aatttggcga cagacaaatg gagttttggt   2220

accactttgt gggaaatctg cagtggagga gataagcctc tgagtgcttt ggattctcag   2280

agaaagctac agttttatga agatagacac caacttcctg caccaaagtg gacagaatta   2340

gcaaatctta ttaataattg tatggattat gaaccagatt ttagaccttc tttcagagcc   2400

atcatacgag atcttaatag tttgtttact ccagattatg aactattaac agaaaatgac   2460

atgttaccaa atatgagaat tggtgcccta gggtttcctg gtgcttttga agaccaagac   2520

cctacacagt ttgaagagag acacttgaaa tttctacagc aacttggcaa gggtaatttt   2580

ggcagtgtgg agatgtgccg atatgaccct ctacaagaca acactgggga ggtggtagct   2640

gtgaagaagc tccagcacag tactgaagag cacctgagag actttgagag ggaaattgaa   2700

atccttaaat ccctgcagca tgacaacatt gtaaagtaca agggagtgtg ctacagtgct   2760

ggccggcgta atctaagatt aattatggaa tatttaccat atggaagttt acgagactac   2820

ctccaaaaac ataaagaacg aatagatcat aaaaaacttc tgcagtatac atctcagata   2880

tgcaagggca tggagtatct tggtacaaaa aggtatatac acagggatct ggcaacaagg   2940

aatatattgg tggagaatga aaacagggtt aaaattggag attttgggtt aaccaaagtc   3000

ttgccacaag acaaagaata ctacaaagtg aaagaacctg gtgaaagtcc catattctgg   3060

tatgctccag aatcattgac agagagcaag ttttctgtgg cttcagatgt ctggagcttt   3120

ggagtggttc tatatgaact tttcacatat attgagaaga gtaaaagtcc accagcggaa   3180

tttatgcgta tgattggcaa cgacaagcaa ggacagatga ttgtgtttca tttgatagaa   3240

ctcctaaaga ataatggaag attaccaaga ccagatggat gcccagatga gatttatttg   3300

atcatgacag aatgctggaa taataatgtg aatcagcggc cctctttcag agacctagct   3360

cttcgagtgg atcagataag ggacaacatg gctggatga                          3399


<210>  3
<211>  28
<212>  DNA
<213>  Artificial

<220>
<223>  amorce

<400>  3
gtttgggcat tttaacatat agcatatt                                        28


<210>  4
<211>  28
<212>  DNA
<213>  Artificial

<220>
<223>  amorce

<400>  4
atgcatttct cttacagcag acagtatc                                        28


