                         SEQUENCE LISTING

<110>  Novozymes A/S
       Naik, Sangeeta
       Saikia, Rakhi
       Basu, Aditya
       Paul, Pritish
       Vasu, Santhosh Maypadum 
       Svendsen, Allan
       De Maria, Leonardo
       Skjt, Michael
		
 
<120>  Variants of a polypeptide with lipolytic activity and improved 
       stability

<130>  11631.000-EP

<160>  9     

<170>  PatentIn version 3.3

<210>  1
<211>  1029
<212>  DNA
<213>  Candida antarctica


<220>
<221>  CDS
<222>  (1)..(1026)

<220>
<221>  sig_peptide
<222>  (1)..(75)

<220>
<221>  mat_peptide
<222>  (76)..(1026)

<400>  1
atg aag cta ctc tct ctg acc ggt gtg gct ggt gtg ctt gcg act tgc       48
Met Lys Leu Leu Ser Leu Thr Gly Val Ala Gly Val Leu Ala Thr Cys         
-25                 -20                 -15                 -10         

gtt gca gcc act cct ttg gtg aag cgt cta cct tcc ggt tcg gac cct       96
Val Ala Ala Thr Pro Leu Val Lys Arg Leu Pro Ser Gly Ser Asp Pro         
                -5              -1  1               5                   

gcc ttt tcg cag ccc aag tcg gtg ctc gat gcg ggt ctg acc tgc cag      144
Ala Phe Ser Gln Pro Lys Ser Val Leu Asp Ala Gly Leu Thr Cys Gln         
        10                  15                  20                      

ggt gct tcg cca tcc tcg gtc tcc aaa ccc atc ctt ctc gtc ccc gga      192
Gly Ala Ser Pro Ser Ser Val Ser Lys Pro Ile Leu Leu Val Pro Gly         
    25                  30                  35                          

acc ggc acc aca ggt cca cag tcg ttc gac tcg aac tgg atc ccc ctc      240
Thr Gly Thr Thr Gly Pro Gln Ser Phe Asp Ser Asn Trp Ile Pro Leu         
40                  45                  50                  55          

tca acg cag ttg ggt tac aca ccc tgc tgg atc tca ccc ccg ccg ttc      288
Ser Thr Gln Leu Gly Tyr Thr Pro Cys Trp Ile Ser Pro Pro Pro Phe         
                60                  65                  70              

atg ctc aac gac acc cag gtc aac acg gag tac atg gtc aac gcc atc      336
Met Leu Asn Asp Thr Gln Val Asn Thr Glu Tyr Met Val Asn Ala Ile         
            75                  80                  85                  

acc gcg ctc tac gct ggt tcg ggc aac aac aag ctt ccc gtg ctt acc      384
Thr Ala Leu Tyr Ala Gly Ser Gly Asn Asn Lys Leu Pro Val Leu Thr         
        90                  95                  100                     

tgg tcc cag ggt ggt ctg gtt gca cag tgg ggt ctg acc ttc ttc ccc      432
Trp Ser Gln Gly Gly Leu Val Ala Gln Trp Gly Leu Thr Phe Phe Pro         
    105                 110                 115                         

agt atc agg tcc aag gtc gat cga ctt atg gcc ttt gcg ccc gac tac      480
Ser Ile Arg Ser Lys Val Asp Arg Leu Met Ala Phe Ala Pro Asp Tyr         
120                 125                 130                 135         

aag ggc acc gtc ctc gcc ggc cct ctc gat gca ctc gcg gtt agt gca      528
Lys Gly Thr Val Leu Ala Gly Pro Leu Asp Ala Leu Ala Val Ser Ala         
                140                 145                 150             

ccc tcc gta tgg cag caa acc acc ggt tcg gca ctc acc acc gca ctc      576
Pro Ser Val Trp Gln Gln Thr Thr Gly Ser Ala Leu Thr Thr Ala Leu         
            155                 160                 165                 

cga aac gca ggt ggt ctg acc cag atc gtg ccc acc acc aac ctc tac      624
Arg Asn Ala Gly Gly Leu Thr Gln Ile Val Pro Thr Thr Asn Leu Tyr         
        170                 175                 180                     

tcg gcg acc gac gag atc gtt cag cct cag gtg tcc aac tcg cca ctc      672
Ser Ala Thr Asp Glu Ile Val Gln Pro Gln Val Ser Asn Ser Pro Leu         
    185                 190                 195                         

gac tca tcc tac ctc ttc aac gga aag aac gtc cag gca cag gcc gtg      720
Asp Ser Ser Tyr Leu Phe Asn Gly Lys Asn Val Gln Ala Gln Ala Val         
200                 205                 210                 215         

tgt ggg ccg ctg ttc gtc atc gac cat gca ggc tcg ctc acc tcg cag      768
Cys Gly Pro Leu Phe Val Ile Asp His Ala Gly Ser Leu Thr Ser Gln         
                220                 225                 230             

ttc tcc tac gtc gtc ggt cga tcc gcc ctg cgc tcc acc acg ggc cag      816
Phe Ser Tyr Val Val Gly Arg Ser Ala Leu Arg Ser Thr Thr Gly Gln         
            235                 240                 245                 

gct cgt agt gca gac tat ggc att acg gac tgc aac cct ctt ccc gcc      864
Ala Arg Ser Ala Asp Tyr Gly Ile Thr Asp Cys Asn Pro Leu Pro Ala         
        250                 255                 260                     

aat gat ctg act ccc gag caa aag gtc gcc gcg gct gcg ctc ctg gcg      912
Asn Asp Leu Thr Pro Glu Gln Lys Val Ala Ala Ala Ala Leu Leu Ala         
    265                 270                 275                         

ccg gca gct gca gcc atc gtg gcg ggt cca aag cag aac tgc gag ccc      960
Pro Ala Ala Ala Ala Ile Val Ala Gly Pro Lys Gln Asn Cys Glu Pro         
280                 285                 290                 295         

gac ctc atg ccc tac gcc cgc ccc ttt gca gta ggc aaa agg acc tgc     1008
Asp Leu Met Pro Tyr Ala Arg Pro Phe Ala Val Gly Lys Arg Thr Cys         
                300                 305                 310             

tcc ggc atc gtc acc ccc tga                                         1029
Ser Gly Ile Val Thr Pro                                                 
            315                                                         


<210>  2
<211>  342
<212>  PRT
<213>  Candida antarctica

<400>  2

Met Lys Leu Leu Ser Leu Thr Gly Val Ala Gly Val Leu Ala Thr Cys 
-25                 -20                 -15                 -10 


Val Ala Ala Thr Pro Leu Val Lys Arg Leu Pro Ser Gly Ser Asp Pro 
                -5              -1  1               5           


Ala Phe Ser Gln Pro Lys Ser Val Leu Asp Ala Gly Leu Thr Cys Gln 
        10                  15                  20              


Gly Ala Ser Pro Ser Ser Val Ser Lys Pro Ile Leu Leu Val Pro Gly 
    25                  30                  35                  


Thr Gly Thr Thr Gly Pro Gln Ser Phe Asp Ser Asn Trp Ile Pro Leu 
40                  45                  50                  55  


Ser Thr Gln Leu Gly Tyr Thr Pro Cys Trp Ile Ser Pro Pro Pro Phe 
                60                  65                  70      


Met Leu Asn Asp Thr Gln Val Asn Thr Glu Tyr Met Val Asn Ala Ile 
            75                  80                  85          


Thr Ala Leu Tyr Ala Gly Ser Gly Asn Asn Lys Leu Pro Val Leu Thr 
        90                  95                  100             


Trp Ser Gln Gly Gly Leu Val Ala Gln Trp Gly Leu Thr Phe Phe Pro 
    105                 110                 115                 


Ser Ile Arg Ser Lys Val Asp Arg Leu Met Ala Phe Ala Pro Asp Tyr 
120                 125                 130                 135 


Lys Gly Thr Val Leu Ala Gly Pro Leu Asp Ala Leu Ala Val Ser Ala 
                140                 145                 150     


Pro Ser Val Trp Gln Gln Thr Thr Gly Ser Ala Leu Thr Thr Ala Leu 
            155                 160                 165         


Arg Asn Ala Gly Gly Leu Thr Gln Ile Val Pro Thr Thr Asn Leu Tyr 
        170                 175                 180             


Ser Ala Thr Asp Glu Ile Val Gln Pro Gln Val Ser Asn Ser Pro Leu 
    185                 190                 195                 


Asp Ser Ser Tyr Leu Phe Asn Gly Lys Asn Val Gln Ala Gln Ala Val 
200                 205                 210                 215 


Cys Gly Pro Leu Phe Val Ile Asp His Ala Gly Ser Leu Thr Ser Gln 
                220                 225                 230     


Phe Ser Tyr Val Val Gly Arg Ser Ala Leu Arg Ser Thr Thr Gly Gln 
            235                 240                 245         


Ala Arg Ser Ala Asp Tyr Gly Ile Thr Asp Cys Asn Pro Leu Pro Ala 
        250                 255                 260             


Asn Asp Leu Thr Pro Glu Gln Lys Val Ala Ala Ala Ala Leu Leu Ala 
    265                 270                 275                 


Pro Ala Ala Ala Ala Ile Val Ala Gly Pro Lys Gln Asn Cys Glu Pro 
280                 285                 290                 295 


Asp Leu Met Pro Tyr Ala Arg Pro Phe Ala Val Gly Lys Arg Thr Cys 
                300                 305                 310     


Ser Gly Ile Val Thr Pro 
            315         


<210>  3
<211>  319
<212>  PRT
<213>  Hyphozyma sp.

<400>  3

Phe Thr Pro Phe Pro Thr Gly Ala Asp Pro Ala Phe Thr Gln Ser Gln 
1               5                   10                  15      


Ala Thr Leu Asp Ala Gly Leu Thr Cys Gln Ser Gly Ser Pro Ser Ser 
            20                  25                  30          


Gln Lys Asn Pro Ile Leu Leu Val Pro Gly Thr Gly Asn Thr Gly Pro 
        35                  40                  45              


Gln Ser Phe Asp Ser Asn Trp Ile Pro Leu Ser Ala Gln Leu Gly Tyr 
    50                  55                  60                  


Ser Pro Cys Trp Val Ser Pro Pro Pro Phe Met Leu Asn Asp Ser Gln 
65                  70                  75                  80  


Ile Asn Ala Glu Tyr Ile Val Asn Ala Ile His Thr Leu Ser Ser Gly 
                85                  90                  95      


Ser Gly Ser Lys Val Pro Val Leu Thr Trp Ser Gln Gly Gly Leu Ala 
            100                 105                 110         


Ala Gln Trp Ala Leu Thr Phe Phe Pro Ser Thr Arg Asn Lys Val Asp 
        115                 120                 125             


Arg Leu Met Ala Phe Ala Pro Asp Tyr Lys Gly Thr Val Glu Ala Gly 
    130                 135                 140                 


Leu Leu Asp Ala Phe Gly Leu Ser Ala Pro Ser Val Trp Gln Gln Thr 
145                 150                 155                 160 


Ala Gln Ser Ala Phe Val Thr Ala Leu Asp Gln Ala Gly Gly Leu Asn 
                165                 170                 175     


Gln Ile Val Pro Thr Thr Asn Leu Tyr Ser Ala Thr Asp Glu Val Val 
            180                 185                 190         


Gln Pro Gln Phe Ala Asn Gly Pro Pro Asp Ser Ser Tyr Leu Ser Asn 
        195                 200                 205             


Gly Lys Asn Ile Gln Ala Gln Ser Ile Cys Gly Pro Leu Phe Ile Ile 
    210                 215                 220                 


Gly His Ala Gly Ser Leu Tyr Ser Gln Phe Ser Tyr Val Val Gly Lys 
225                 230                 235                 240 


Ser Ala Leu Ala Ser Pro Thr Gly Gln Ala Gln Ser Ser Asp Tyr Ser 
                245                 250                 255     


Ile Lys Asp Cys Asn Pro Ala Pro Ala Asn Pro Leu Thr Ala Gln Gln 
            260                 265                 270         


Lys Leu Asp Ser Ala Ala Ile Ile Leu Val Ala Gly Lys Asn Ile Val 
        275                 280                 285             


Thr Gly Pro Lys Gln Asn Cys Glu Pro Asp Leu Met Pro Tyr Ala Arg 
    290                 295                 300                 


Lys Tyr Arg Ile Gly Lys Lys Thr Cys Ser Gly Val Ile Thr Gly 
305                 310                 315                 


<210>  4
<211>  336
<212>  PRT
<213>  Ustilago maydis

<400>  4

Met Lys Thr Thr Ser Val Ile Ser Ala Leu Val Thr Leu Ala Ser Ile 
1               5                   10                  15      


Ile Arg Ala Ala Pro Leu Ala Ser Ser Asp Pro Ala Phe Ser Thr Pro 
            20                  25                  30          


Lys Ala Thr Leu Asp Ala Gly Leu Glu Cys Gln Thr Gly Ser Pro Ser 
        35                  40                  45              


Ser Gln Thr Lys Pro Ile Leu Leu Val Pro Gly Thr Gly Ala Asn Gly 
    50                  55                  60                  


Thr Gln Thr Phe Asp Ser Ser Trp Ile Pro Leu Ser Ala Lys Leu Gly 
65                  70                  75                  80  


Phe Ser Pro Cys Trp Ile Ser Pro Pro Pro Phe Met Leu Asn Asp Ser 
                85                  90                  95      


Gln Val Asn Val Glu Tyr Ile Val Asn Ala Val Gln Thr Leu Tyr Ala 
            100                 105                 110         


Gly Ser Gly Ser Lys Lys Val Pro Val Leu Thr Trp Ser Gln Gly Gly 
        115                 120                 125             


Leu Ala Thr Gln Trp Ala Leu Thr Phe Phe Pro Ser Ile Arg Asn Gln 
    130                 135                 140                 


Val Asp Arg Leu Met Ala Phe Ala Pro Asp Tyr Lys Gly Thr Ile Glu 
145                 150                 155                 160 


Ala Gly Leu Leu Ser Thr Phe Gly Leu Ala Ser Gln Ser Val Trp Gln 
                165                 170                 175     


Gln Gln Ala Gly Ser Ala Phe Val Thr Ala Leu Lys Asn Ala Gly Gly 
            180                 185                 190         


Leu Thr Ser Phe Val Pro Thr Thr Asn Leu Tyr Ser Phe Phe Asp Glu 
        195                 200                 205             


Ile Val Gln Pro Gln Val Phe Asn Ser Asp Ala Asp Ser Ser Tyr Leu 
    210                 215                 220                 


Gly Asn Ser Lys Asn Ile Gln Ala Gln Thr Val Cys Gly Gly Phe Phe 
225                 230                 235                 240 


Val Ile Asp His Ala Gly Ser Leu Thr Ser Gln Phe Ser Tyr Val Val 
                245                 250                 255     


Gly Lys Ser Ala Leu Thr Ser Ser Ser Gly Val Ala Asn Ser Ala Asp 
            260                 265                 270         


Tyr Ser Ser Lys Asp Cys Lys Ala Ser Pro Ala Asp Asp Leu Ser Ala 
        275                 280                 285             


Lys Gln Lys Ala Asp Ala Ser Ala Leu Leu Phe Val Ala Ala Gly Asn 
    290                 295                 300                 


Leu Leu Ala Gly Pro Lys Gln Asn Cys Glu Pro Asp Leu Lys Pro Tyr 
305                 310                 315                 320 


Ala Arg Gln Phe Ala Val Gly Lys Lys Thr Cys Ser Gly Thr Ile Asn 
                325                 330                 335     


<210>  5
<211>  445
<212>  PRT
<213>  Gibberella zeae

<400>  5

Ala Pro Ser Tyr Ser Asp Leu Glu Ser Arg Gln Leu Ile Gly Gly Leu 
1               5                   10                  15      


Leu Lys Gly Val Asp Gly Thr Leu Glu Thr Val Val Gly Gly Leu Leu 
            20                  25                  30          


Gly Thr Leu Arg Lys Ala Ile Asp Ser Gly Asp Arg Asp Lys Thr Leu 
        35                  40                  45              


Asp Ile Leu His Val Leu Glu Pro Ala Lys Lys His Lys Asn Val Glu 
    50                  55                  60                  


Glu Ala Phe Ala Ala Leu Glu Lys Ile Ser Lys Ser Lys Pro Lys Thr 
65                  70                  75                  80  


Ile Ile Asp Tyr Ser Ala Gln Leu Ile Val Asn Gly Leu Ile Ser Gly 
                85                  90                  95      


Asn Thr Leu Asp Leu Phe Ala Tyr Ala Lys Gly Leu Val Ser Ala Gln 
            100                 105                 110         


Asn Gly Ser Asn Asn Lys Asn Arg Asn Pro Pro Lys Glu Val Tyr Pro 
        115                 120                 125             


Lys Val Ala Asn Cys Asp Ala Ser Tyr Thr Thr Ser Glu Ala Lys Leu 
    130                 135                 140                 


Arg Ala Ala Ile His Ile Pro Pro Thr Phe Thr Tyr Gly Glu Lys Pro 
145                 150                 155                 160 


Pro Val Ile Leu Phe Pro Gly Thr Gly Ser Thr Gly Phe Thr Thr Tyr 
                165                 170                 175     


Arg Gly Asn Phe Ile Pro Leu Leu Thr Asp Val Glu Trp Ala Asp Pro 
            180                 185                 190         


Val Trp Val Asn Val Pro Val Leu Leu Leu Glu Asp Ala Gln Val Asn 
        195                 200                 205             


Ala Glu Tyr Ala Ala Tyr Ala Leu Asn Tyr Ile Ala Ser Leu Thr Lys 
    210                 215                 220                 


Arg Asn Val Ser Val Ile Ala Trp Ser Gln Gly Asn Ile Asp Val Gln 
225                 230                 235                 240 


Trp Ala Leu Lys Tyr Trp Pro Ser Thr Arg Lys Val Thr Thr Asp His 
                245                 250                 255     


Val Ala Ile Ser Ala Asp Tyr Lys Gly Thr Ile Leu Ala Asn Ile Gly 
            260                 265                 270         


Gly Ala Thr Gly Leu Ile Asn Thr Pro Ala Val Val Gln Gln Glu Ala 
        275                 280                 285             


Gly Ser Thr Phe Ile Asn Thr Leu Arg Ser Asn Asp Gly Asp Ser Gly 
    290                 295                 300                 


Tyr Ile Pro Thr Thr Ser Leu Tyr Ser Ser Leu Phe Asp Glu Val Val 
305                 310                 315                 320 


Gln Pro Gln Glu Gly Ala Gly Ala Ser Ala Tyr Leu Leu Asp Ala Arg 
                325                 330                 335     


Asp Val Gly Val Thr Asn Ala Glu Val Gln Lys Val Cys Thr Gly Lys 
            340                 345                 350         


Leu Gly Gly Ser Phe Tyr Thr His Glu Ser Met Leu Ala Asn Pro Leu 
        355                 360                 365             


Thr Phe Ala Leu Ala Lys Asp Ala Leu Thr His Glu Gly Pro Gly Thr 
    370                 375                 380                 


Ile Ser Arg Leu Asp Leu Ala Asp Val Cys Asn Arg Ser Leu Ala Pro 
385                 390                 395                 400 


Gly Leu Gly Leu Lys Asp Leu Leu Ile Thr Glu Asn Ala Val Val Ile 
                405                 410                 415     


Ala Ala Leu Ser Leu Val Leu Tyr Leu Pro Lys Gln Ile Asp Glu Pro 
            420                 425                 430         


Ala Ile Lys Gln Tyr Ala Leu Glu Ala Thr Gly Thr Cys 
        435                 440                 445 


<210>  6
<211>  455
<212>  PRT
<213>  Debaryomyces hansenii

<400>  6

His Pro Thr Lys Glu Leu Glu Arg Arg Asp Leu Ile Ser Asn Ile Asp 
1               5                   10                  15      


Asp Ile Val Asn Ser Thr Ile Asp Asn Gly Glu Ala His Lys Asp Asn 
            20                  25                  30          


Ala Lys Ser Ala Ile Thr Asp Ile Phe Asp Lys Ile Asn Asp Gly Ile 
        35                  40                  45              


Lys Gln Asp Ile Asp Asn Leu Lys Glu Val Gly Lys Ser Ile Ala Asp 
    50                  55                  60                  


Leu Ile Lys Ser Val Val Pro Thr Glu Asp Leu Ser Thr Pro Glu Gly 
65                  70                  75                  80  


Val Gln Ala Tyr Leu Gly Gln Leu Phe Glu Asn Gly Glu Asp Leu Phe 
                85                  90                  95      


Lys Asn Ser Ile Asp Met Val Gly His Gly Leu Lys Pro Gly Ser Ile 
            100                 105                 110         


Ala Gly Asn Phe Glu Gly Phe Ser Asp Glu Ile Asn Thr Ser Asp Asn 
        115                 120                 125             


Phe Asn Val Lys Glu Pro Glu Gly Ser Val Tyr Pro Gln Ala Glu Ser 
    130                 135                 140                 


Glu Asp Pro Ser Phe Ser Leu Ser Glu Glu Gln Leu Arg Ser Ala Ile 
145                 150                 155                 160 


Gln Ile Pro Glu Glu Phe Gln Tyr Gly Asn Gly Ser Lys Ser Pro Val 
                165                 170                 175     


Ile Leu Val Pro Gly Thr Gly Ser Lys Gly Gly Met Thr Tyr Ala Ser 
            180                 185                 190         


Asn Tyr Ala Lys Leu Leu Lys Glu Thr Asp Phe Ala Asp Val Val Trp 
        195                 200                 205             


Leu Asn Val Pro Gly Tyr Leu Leu Asp Asp Ala Gln Asn Asn Ala Glu 
    210                 215                 220                 


Tyr Val Ala Tyr Ala Ile Asn Tyr Ile Ser Gly Ile Ser Asn Asn Lys 
225                 230                 235                 240 


Asn Val Ser Ile Ile Ser Trp Ser Gln Gly Gly Leu Asp Thr Gln Trp 
                245                 250                 255     


Ala Leu Lys Tyr Trp Ala Ser Thr Arg Ser Lys Val Ser Asp Phe Ile 
            260                 265                 270         


Pro Ile Ser Pro Asp Phe Lys Gly Thr Arg Met Val Pro Val Leu Cys 
        275                 280                 285             


Pro Ser Phe Pro Lys Leu Ser Cys Pro Pro Ser Val Leu Gln Gln Glu 
    290                 295                 300                 


Tyr Asn Ser Thr Phe Ile Glu Thr Leu Arg Ala Asp Gly Gly Asp Ser 
305                 310                 315                 320 


Ala Tyr Val Pro Thr Thr Ser Ile Tyr Ser Gly Phe Asp Glu Ile Val 
                325                 330                 335     


Gln Pro Gln Ser Gly Lys Gly Ala Ser Gly Leu Ile Asn Asp Asn Arg 
            340                 345                 350         


Asn Val Gly Val Thr Asn Asn Glu Val Gln Thr Ile Cys Pro Asp Arg 
        355                 360                 365             


Pro Ala Gly Lys Tyr Tyr Thr His Glu Gly Val Leu Tyr Asn Pro Val 
    370                 375                 380                 


Gly Tyr Ala Leu Ala Val Asp Ala Leu Thr His Glu Gly Pro Gly Gln 
385                 390                 395                 400 


Leu Ser Arg Ile Asp Leu Asp Thr Glu Cys Gly Arg Ile Val Pro Asp 
                405                 410                 415     


Gly Leu Thr Tyr Thr Asp Leu Leu Ala Thr Glu Ala Leu Ile Pro Glu 
            420                 425                 430         


Ala Leu Val Leu Ile Leu Ser Tyr Asp Asp Lys Thr Arg Asp Glu Pro 
        435                 440                 445             


Glu Ile Arg Ser Tyr Ala Gln 
    450                 455 


<210>  7
<211>  440
<212>  PRT
<213>  Aspergillus fumigatus

<400>  7

Ala Val Ile Pro Arg Gly Ala Val Pro Val Ala Ser Asp Leu Ser Leu 
1               5                   10                  15      


Val Ser Ile Leu Ser Ser Ala Ala Asn Asp Ser Ser Ile Glu Ser Glu 
            20                  25                  30          


Ala Arg Ser Ile Ala Ser Leu Ile Ala Ser Glu Ile Val Ser Lys Ile 
        35                  40                  45              


Gly Lys Thr Glu Phe Ser Arg Ser Thr Lys Asp Ala Lys Ser Val Gln 
    50                  55                  60                  


Glu Ala Phe Asp Lys Ile Gln Ser Ile Phe Ala Asp Gly Thr Pro Asp 
65                  70                  75                  80  


Phe Leu Lys Met Thr Arg Glu Ile Leu Thr Val Gly Leu Ile Pro Ala 
                85                  90                  95      


Asp Ile Val Ser Phe Leu Asn Gly Tyr Leu Asn Leu Asp Leu Asn Ser 
            100                 105                 110         


Ile His Asn Arg Asn Pro Ser Pro Lys Gly Gln Ala Ile Tyr Pro Val 
        115                 120                 125             


Lys Ala Pro Gly Asp Ala Arg Tyr Ser Val Ala Glu Asn Ala Leu Arg 
    130                 135                 140                 


Ala Ala Ile His Ile Pro Ala Ser Phe Gly Tyr Gly Lys Asn Gly Lys 
145                 150                 155                 160 


Lys Pro Val Ile Leu Val Pro Gly Thr Ala Thr Pro Ala Gly Thr Thr 
                165                 170                 175     


Tyr Tyr Phe Asn Phe Gly Lys Leu Gly Ser Ala Ala Asp Ala Asp Val 
            180                 185                 190         


Val Trp Leu Asn Ile Pro Gln Ala Ser Leu Asn Asp Val Gln Ile Asn 
        195                 200                 205             


Ser Glu Tyr Val Ala Tyr Ala Ile Asn Tyr Ile Ser Ala Ile Ser Glu 
    210                 215                 220                 


Ser Asn Val Ala Val Leu Ser Trp Ser Gln Gly Gly Leu Asp Thr Gln 
225                 230                 235                 240 


Trp Ala Leu Lys Tyr Trp Pro Ser Thr Arg Lys Val Val Asp Asp Phe 
                245                 250                 255     


Ile Ala Ile Ser Pro Asp Phe His Gly Thr Val Met Arg Ser Leu Val 
            260                 265                 270         


Cys Pro Trp Leu Ala Ala Leu Ala Cys Thr Pro Ser Leu Trp Gln Gln 
        275                 280                 285             


Gly Trp Asn Thr Glu Phe Ile Arg Thr Leu Arg Gly Gly Gly Gly Asp 
    290                 295                 300                 


Ser Ala Tyr Val Pro Thr Thr Thr Ile Tyr Ser Thr Phe Asp Glu Ile 
305                 310                 315                 320 


Val Gln Pro Met Ser Gly Ser Gln Ala Ser Ala Ile Leu Ser Asp Ser 
                325                 330                 335     


Arg Ala Val Gly Val Ser Asn Asn His Leu Gln Thr Ile Cys Gly Gly 
            340                 345                 350         


Lys Pro Ala Gly Gly Val Tyr Thr His Glu Gly Val Leu Tyr Asn Pro 
        355                 360                 365             


Leu Ala Trp Ala Leu Ala Val Asp Ala Leu Ser His Asp Gly Pro Gly 
    370                 375                 380                 


Asp Pro Ser Arg Leu Asp Leu Asp Val Val Cys Gly Arg Val Leu Pro 
385                 390                 395                 400 


Pro Gln Leu Gly Leu Asp Asp Leu Leu Gly Thr Glu Gly Leu Leu Leu 
                405                 410                 415     


Ile Ala Leu Ala Glu Val Leu Ala Tyr Lys Pro Lys Thr Phe Gly Glu 
            420                 425                 430         


Pro Ala Ile Ala Ser Tyr Ala His 
        435                 440 


<210>  8
<211>  401
<212>  PRT
<213>  Aspergillus oryzae

<400>  8

Leu Pro Ser Ser Ser Glu Thr Val Glu Ala Asn Cys Val Lys Pro Tyr 
1               5                   10                  15      


Leu Cys Cys Gly Glu Leu Lys Thr Pro Leu Asp Ser Thr Leu Asp Pro 
            20                  25                  30          


Ile Leu Leu Asp Leu Gly Ile Asp Ala Ala Ser Ile Val Gly Ser Val 
        35                  40                  45              


Gly Leu Leu Cys Leu Ile Pro Ser Lys Ala Leu Thr Cys Leu Asn Gly 
    50                  55                  60                  


Tyr Ala Ile Ile Asp Leu Asn Ser Ile His Arg His Asn Pro Ser Pro 
65                  70                  75                  80  


Glu Asn Leu Ser Ile Tyr Pro Tyr Lys Ala Lys Ser Asp Ala Pro Tyr 
                85                  90                  95      


Ser Ile Ala Glu Asn Thr Leu Arg Ala Ala Ile His Ile Pro Arg Ser 
            100                 105                 110         


Phe Ser His Lys Arg Asp Lys Lys Ile Pro Val Leu Leu Val Pro Gly 
        115                 120                 125             


Thr Ala Val Pro Ala Ala Ile Thr Phe Tyr Phe Asn Phe Gly Lys Leu 
    130                 135                 140                 


Arg Arg Ala Leu Pro Glu Ser Glu Leu Val Trp Ile Asp Leu Pro Gln 
145                 150                 155                 160 


Ala Ser Leu Asp Asp Ile Gln Leu Ser Ala Glu Tyr Val Ala Tyr Ala 
                165                 170                 175     


Leu Asn Tyr Val Ser Ala Leu Thr Ser Ser Lys Ile Ala Val Ile Ser 
            180                 185                 190         


Trp Ser Gln Gly Ala Leu Asp Ile Gln Trp Ala Leu Lys Tyr Trp Pro 
        195                 200                 205             


Ser Thr Arg Ser Val Val Asn Asp Phe Ile Ala Ile Ser Pro Asp Phe 
    210                 215                 220                 


His Gly Thr Ile Val Lys Trp Leu Val Cys Pro Leu Leu Asn Asp Leu 
225                 230                 235                 240 


Ala Cys Thr Pro Ser Ile Trp Gln Gln Gly Trp Asp Ala Asn Phe Ile 
                245                 250                 255     


Gln Ala Leu Arg Ser Gln Gly Gly Asp Ser Ala Tyr Val Thr Thr Thr 
            260                 265                 270         


Thr Ile Tyr Ser Ser Phe Asp Lys Ile Val Arg Pro Met Ser Gly Glu 
        275                 280                 285             


Asn Ala Ser Ala Arg Leu Leu Asp Tyr Arg Gly Val Gly Val Ser Asn 
    290                 295                 300                 


Asn His Leu Gln Thr Ile Cys Ala Asn Asn Ala Ala Gly Gly Leu Tyr 
305                 310                 315                 320 


Thr His Glu Gly Val Leu Tyr Asn Pro Leu Ala Trp Ala Leu Thr Val 
                325                 330                 335     


Asp Ala Leu Leu His Asp Gly Pro Ser Asn Ile Thr Arg Ile Asp Thr 
            340                 345                 350         


Gln Lys Ile Cys Glu Gln Val Leu Pro Pro Tyr Leu Glu Leu Thr Asp 
        355                 360                 365             


Met Leu Gly Thr Glu Ala Leu Leu Leu Val Ala Leu Ala Lys Ile Leu 
    370                 375                 380                 


Thr Tyr Ser Pro Lys Val Ser Gly Glu Pro Asp Ile Ala Lys Tyr Ala 
385                 390                 395                 400 


Tyr 
    


<210>  9
<211>  388
<212>  PRT
<213>  Neurospora crassa

<400>  9

Leu Pro Thr Thr Ser Glu Pro Val His His Glu Ser Val Arg Ala Ile 
1               5                   10                  15      


Gly Glu Leu Ser His Arg Asp Glu Leu His Asp Ala Gly Val Val Trp 
            20                  25                  30          


Asn Lys Val Val Arg Gln Ser Pro Leu Val Ala Pro Thr Asp Pro Arg 
        35                  40                  45              


Asp Ser Phe Asn Asn Gln Asn Pro Asp Val Pro Gly Val Gly Tyr Pro 
    50                  55                  60                  


Arg Ser Ser Asp Ala Asp Pro Ala Phe Thr Ile Pro Glu Ala Lys Leu 
65                  70                  75                  80  


Arg Ser Ala Ile Tyr Leu Pro Ser Gly Phe Asn Ser Ser Thr Asn Arg 
                85                  90                  95      


Gln Val Val Leu Phe Val Pro Gly Thr Gly Ala Tyr Gly His Glu Ser 
            100                 105                 110         


Phe Ala Asp Asn Leu Leu Lys Val Ile Thr Asn Ala Gly Ala Ala Asp 
        115                 120                 125             


Ala Val Trp Val Asn Val Pro Asn Ala Met Leu Asp Asp Val Gln Ser 
    130                 135                 140                 


Asn Ala Glu Tyr Ile Ala Tyr Ala Ile Ser Tyr Val Lys Ala Leu Ile 
145                 150                 155                 160 


Gly Asp Asp Arg Asp Leu Asn Val Ile Gly Trp Ser Gln Gly Asn Leu 
                165                 170                 175     


Ala Thr Gln Trp Val Leu Thr Tyr Trp Pro Ser Thr Ala Pro Lys Val 
            180                 185                 190         


Arg Gln Leu Ile Ser Val Ser Pro Asp Phe His Gly Thr Met Leu Ala 
        195                 200                 205             


Tyr Gly Leu Cys Ala Gly Asn Phe Gly Lys Val Ala Lys Ala Gly Ala 
    210                 215                 220                 


Pro Cys Pro Pro Ser Val Leu Gln Gln Leu Tyr Ser Ser Asn Leu Ile 
225                 230                 235                 240 


Asn Thr Leu Arg Ala Ala Gly Gly Gly Asp Ala Gln Val Pro Thr Thr 
                245                 250                 255     


Ser Phe Trp Ser Arg Leu Thr Asp Glu Val Val Gln Pro Gln Ala Gly 
            260                 265                 270         


Leu Thr Ala Ser Ala Arg Met Gly Asp Ala Arg Asn Lys Gly Val Thr 
        275                 280                 285             


Asn Val Glu Val Gln Thr Val Cys Gly Leu Ser Val Gly Gly Gly Gln 
    290                 295                 300                 


Tyr Gly His Ser Thr Leu Met Ala His Pro Leu Val Ala Ala Met Thr 
305                 310                 315                 320 


Leu Asp Ala Leu Lys Asn Gly Gly Pro Ala Ser Leu Ser Arg Ile Arg 
                325                 330                 335     


Ser Gln Met Phe Arg Ala Cys Ser Asn Val Val Ala Pro Gly Leu Gln 
            340                 345                 350         


Leu Thr Asp Arg Ala Lys Thr Glu Gly Leu Leu Ala Thr Ala Gly Ala 
        355                 360                 365             


Arg Met Gly Ala Phe Pro Thr Lys Leu Leu Arg Glu Pro Ala Leu Arg 
    370                 375                 380                 


Gln Tyr Ala Ala 
385             


