                              Sequence Listing

<110> GENENTECH, INC. et al.

<120> COMPOSITIONS AND METHODS FOR THE DIAGNOSIS AND 
      TREATMENT OF TUMOR

<130> P5041R1 WO


<150> US 61/384,467
<151> 2010-09-20

<150> US 61/265,262
<151> 2009-11-30

<160> 81

<210> 1
<211> 2366
<212> DNA
<213> Homo sapiens

<400> 1
 cagcccagca cctgcggagg gagcgctgac catggctccc tggcctgaat 50

 tgggagatgc ccagcccaac cccgataagt acctcgaagg ggccgcaggt 100

 cagcagccca ctgcccctga taaaagcaaa gagaccaaca aaacagataa 150

 cactgaggca cctgtaacca agattgaact tctgccgtcc tactccacgg 200

 ctacactgat agatgagccc actgaggtgg atgacccctg gaacctaccc 250

 actcttcagg actcggggat caagtggtca gagagagaca ccaaagggaa 300

 gattctctgt ttcttccaag ggattgggag attgatttta cttctcggat 350

 ttctctactt tttcgtgtgc tccctggata ttcttagtag cgccttccag 400

 ctggttggag gaaaaatggc aggacagttc ttcagcaaca gctctattat 450

 gtccaaccct ttgttggggc tggtgatcgg ggtgctggtg accgtcttgg 500

 tgcagagctc cagcacctca acgtccatcg ttgtcagcat ggtgtcctct 550

 tcattgctca ctgttcgggc tgccatcccc attatcatgg gggccaacat 600

 tggaacgtca atcaccaaca ctattgttgc gctcatgcag gtgggagatc 650

 ggagtgagtt cagaagagct tttgcaggag ccactgtcca tgacttcttc 700

 aactggctgt ccgtgttggt gctcttgccc gtggaggtgg ccacccatta 750

 cctcgagatc ataacccagc ttatagtgga gagcttccac ttcaagaatg 800

 gagaagatgc cccagatctt ctgaaagtca tcactaagcc cttcacaaag 850

 ctcattgtcc agctggataa aaaagttatc agccaaattg caatgaacga 900

 tgaaaaagcg aaaaacaaga gtcttgtcaa gatttggtgc aaaactttta 950

 ccaacaagac ccagattaac gtcactgttc cctcgactgc taactgcacc 1000

 tccccttccc tctgttggac ggatggcatc caaaactgga ccatgaagaa 1050

 tgtgacctac aaggagaaca tcgccaaatg ccagcatatc tttgtgaatt 1100

 tccacctccc ggatcttgct gtgggcacca tcttgctcat actctccctg 1150

 ctggtcctct gtggttgcct gatcatgatt gtcaagatcc tgggctctgt 1200

 gctcaagggg caggtcgcca ctgtcatcaa gaagaccatc aacactgatt 1250

 tcccctttcc ctttgcatgg ttgactggct acctggccat cctcgtcggg 1300

 gcaggcatga ccttcatcgt acagagcagc tctgtgttca cgtcggcctt 1350

 gacccccctg attggaatcg gcgtgataac cattgagagg gcttatccac 1400

 tcacgctggg ctccaacatc ggcaccacca ccaccgccat cctggccgcc 1450

 ttagccagcc ctggcaatgc attgaggagt tcactccaga tcgccctgtg 1500

 ccactttttc ttcaacatct ccggcatctt gctgtggtac ccgatcccgt 1550

 tcactcgcct gcccatccgc atggccaagg ggctgggcaa catctctgcc 1600

 aagtatcgct ggttcgccgt cttctacctg atcatcttct tcttcctgat 1650

 cccgctgacg gtgtttggcc tctcgctggc cggctggcgg gtgctggttg 1700

 gtgtcggggt tcccgtcgtc ttcatcatca tcctggtact gtgcctccga 1750

 ctcctgcagt ctcgctgccc acgcgtcctg ccgaagaaac tccagaactg 1800

 gaacttcctg ccgctgtgga tgcgctcgct gaagccctgg gatgccgtcg 1850

 tctccaagtt caccggctgc ttccagatgc gctgctgctg ctgctgccgc 1900

 gtgtgctgcc gcgcgtgctg cttgctgtgt ggctgcccca agtgctgccg 1950

 ctgcagcaag tgctgcgagg acttggagga ggcgcaggag gggcaggatg 2000

 tccctgtcaa ggctcctgag acctttgata acataaccat tagcagagag 2050

 gctcagggtg aggtccctgc ctcggactca aagaccgaat gcacggcctt 2100

 gtaggggacg ccccagattg tcagggatgg ggggatggtc cttgagtttt 2150

 gcatgctctc ctccctccca cttctgcacc ctttcaccac ctcgaggaga 2200

 tttgctcccc attagcgaat gaaattgatg cagtcctacc taactcgatt 2250

 ccctttggct tggtgggtag gcctgcaggg cacttttatt ccaacccatg 2300

 gcctccatga ctttttcaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa 2350

 aaaaaaaaaa  aaaaaa 2366

<210> 2
<211> 690
<212> PRT
<213> Homo sapiens

<400> 2
 Met Ala Pro Trp Pro Glu Leu Gly Asp Ala Gln Pro Asn Pro Asp
   1               5                  10                  15

 Lys Tyr Leu Glu Gly Ala Ala Gly Gln Gln Pro Thr Ala Pro Asp
                  20                  25                  30

 Lys Ser Lys Glu Thr Asn Lys Thr Asp Asn Thr Glu Ala Pro Val
                  35                  40                  45

 Thr Lys Ile Glu Leu Leu Pro Ser Tyr Ser Thr Ala Thr Leu Ile
                  50                  55                  60

 Asp Glu Pro Thr Glu Val Asp Asp Pro Trp Asn Leu Pro Thr Leu
                  65                  70                  75

 Gln Asp Ser Gly Ile Lys Trp Ser Glu Arg Asp Thr Lys Gly Lys
                  80                  85                  90

 Ile Leu Cys Phe Phe Gln Gly Ile Gly Arg Leu Ile Leu Leu Leu
                  95                 100                 105

 Gly Phe Leu Tyr Phe Phe Val Cys Ser Leu Asp Ile Leu Ser Ser
                 110                 115                 120

 Ala Phe Gln Leu Val Gly Gly Lys Met Ala Gly Gln Phe Phe Ser
                 125                 130                 135

 Asn Ser Ser Ile Met Ser Asn Pro Leu Leu Gly Leu Val Ile Gly
                 140                 145                 150

 Val Leu Val Thr Val Leu Val Gln Ser Ser Ser Thr Ser Thr Ser
                 155                 160                 165

 Ile Val Val Ser Met Val Ser Ser Ser Leu Leu Thr Val Arg Ala
                 170                 175                 180

 Ala Ile Pro Ile Ile Met Gly Ala Asn Ile Gly Thr Ser Ile Thr
                 185                 190                 195

 Asn Thr Ile Val Ala Leu Met Gln Val Gly Asp Arg Ser Glu Phe
                 200                 205                 210

 Arg Arg Ala Phe Ala Gly Ala Thr Val His Asp Phe Phe Asn Trp
                 215                 220                 225

 Leu Ser Val Leu Val Leu Leu Pro Val Glu Val Ala Thr His Tyr
                 230                 235                 240

 Leu Glu Ile Ile Thr Gln Leu Ile Val Glu Ser Phe His Phe Lys
                 245                 250                 255

 Asn Gly Glu Asp Ala Pro Asp Leu Leu Lys Val Ile Thr Lys Pro
                 260                 265                 270

 Phe Thr Lys Leu Ile Val Gln Leu Asp Lys Lys Val Ile Ser Gln
                 275                 280                 285

 Ile Ala Met Asn Asp Glu Lys Ala Lys Asn Lys Ser Leu Val Lys
                 290                 295                 300

 Ile Trp Cys Lys Thr Phe Thr Asn Lys Thr Gln Ile Asn Val Thr
                 305                 310                 315

 Val Pro Ser Thr Ala Asn Cys Thr Ser Pro Ser Leu Cys Trp Thr
                 320                 325                 330

 Asp Gly Ile Gln Asn Trp Thr Met Lys Asn Val Thr Tyr Lys Glu
                 335                 340                 345

 Asn Ile Ala Lys Cys Gln His Ile Phe Val Asn Phe His Leu Pro
                 350                 355                 360

 Asp Leu Ala Val Gly Thr Ile Leu Leu Ile Leu Ser Leu Leu Val
                 365                 370                 375

 Leu Cys Gly Cys Leu Ile Met Ile Val Lys Ile Leu Gly Ser Val
                 380                 385                 390

 Leu Lys Gly Gln Val Ala Thr Val Ile Lys Lys Thr Ile Asn Thr
                 395                 400                 405

 Asp Phe Pro Phe Pro Phe Ala Trp Leu Thr Gly Tyr Leu Ala Ile
                 410                 415                 420

 Leu Val Gly Ala Gly Met Thr Phe Ile Val Gln Ser Ser Ser Val
                 425                 430                 435

 Phe Thr Ser Ala Leu Thr Pro Leu Ile Gly Ile Gly Val Ile Thr
                 440                 445                 450

 Ile Glu Arg Ala Tyr Pro Leu Thr Leu Gly Ser Asn Ile Gly Thr
                 455                 460                 465

 Thr Thr Thr Ala Ile Leu Ala Ala Leu Ala Ser Pro Gly Asn Ala
                 470                 475                 480

 Leu Arg Ser Ser Leu Gln Ile Ala Leu Cys His Phe Phe Phe Asn
                 485                 490                 495

 Ile Ser Gly Ile Leu Leu Trp Tyr Pro Ile Pro Phe Thr Arg Leu
                 500                 505                 510

 Pro Ile Arg Met Ala Lys Gly Leu Gly Asn Ile Ser Ala Lys Tyr
                 515                 520                 525

 Arg Trp Phe Ala Val Phe Tyr Leu Ile Ile Phe Phe Phe Leu Ile
                 530                 535                 540

 Pro Leu Thr Val Phe Gly Leu Ser Leu Ala Gly Trp Arg Val Leu
                 545                 550                 555

 Val Gly Val Gly Val Pro Val Val Phe Ile Ile Ile Leu Val Leu
                 560                 565                 570

 Cys Leu Arg Leu Leu Gln Ser Arg Cys Pro Arg Val Leu Pro Lys
                 575                 580                 585

 Lys Leu Gln Asn Trp Asn Phe Leu Pro Leu Trp Met Arg Ser Leu
                 590                 595                 600

 Lys Pro Trp Asp Ala Val Val Ser Lys Phe Thr Gly Cys Phe Gln
                 605                 610                 615

 Met Arg Cys Cys Cys Cys Cys Arg Val Cys Cys Arg Ala Cys Cys
                 620                 625                 630

 Leu Leu Cys Gly Cys Pro Lys Cys Cys Arg Cys Ser Lys Cys Cys
                 635                 640                 645

 Glu Asp Leu Glu Glu Ala Gln Glu Gly Gln Asp Val Pro Val Lys
                 650                 655                 660

 Ala Pro Glu Thr Phe Asp Asn Ile Thr Ile Ser Arg Glu Ala Gln
                 665                 670                 675

 Gly Glu Val Pro Ala Ser Asp Ser Lys Thr Glu Cys Thr Ala Leu
                 680                 685                 690

<210> 3
<211> 91
<212> PRT
<213> Homo sapiens

<400> 3
 Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val
   1               5                  10                  15

 Gly Asp Arg Val Thr Ile Thr Cys Gly Lys Ala Pro Lys Leu Leu
                  20                  25                  30

 Ile Tyr Ala Ala Ser Ser Leu Glu Ser Gly Val Pro Ser Arg Phe
                  35                  40                  45

 Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser
                  50                  55                  60

 Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Asn
                  65                  70                  75

 Ser Leu Pro Trp Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys
                  80                  85                  90

 Arg
    

<210> 4
<211> 113
<212> PRT
<213> Homo sapiens

<400> 4
 Asp Ile Leu Met Thr Gln Thr Pro Leu Ser Leu Pro Val Ser Leu
   1               5                  10                  15

 Gly Asp Gln Ala Ser Ile Ser Cys Arg Ser Ser Glu Thr Leu Val
                  20                  25                  30

 His Ser Asn Gly Asn Thr Tyr Leu Glu Trp Tyr Leu Gln Lys Leu
                  35                  40                  45

 Gly Gln Pro Pro Lys Leu Leu Ile Tyr Arg Val Ser Asn Arg Phe
                  50                  55                  60

 Ser Gly Val Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp
                  65                  70                  75

 Phe Thr Leu Lys Ile Ser Arg Leu Glu Ala Glu Asp Leu Gly Val
                  80                  85                  90

 Tyr Tyr Cys Phe Gln Gly Ser His Asn Pro Leu Thr Phe Gly Ala
                  95                 100                 105

 Gly Thr Lys Val Glu Ile Lys Arg
                 110            

<210> 5
<211> 113
<212> PRT
<213> Homo sapiens

<400> 5
 Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val
   1               5                  10                  15

 Gly Asp Arg Val Thr Ile Thr Cys Arg Ser Ser Glu Thr Leu Val
                  20                  25                  30

 His Ser Asn Gly Asn Thr Tyr Leu Glu Trp Tyr Gln Gln Lys Pro
                  35                  40                  45

 Gly Lys Ala Pro Lys Leu Leu Ile Tyr Arg Val Ser Asn Arg Phe
                  50                  55                  60

 Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp
                  65                  70                  75

 Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr
                  80                  85                  90

 Tyr Tyr Cys Phe Gln Gly Ser His Asn Pro Leu Thr Phe Gly Gln
                  95                 100                 105

 Gly Thr Lys Val Glu Ile Lys Arg
                 110            

<210> 6
<211> 113
<212> PRT
<213> Homo sapiens

<400> 6
 Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val
   1               5                  10                  15

 Gly Asp Arg Val Thr Ile Thr Cys Arg Ser Ser Glu Thr Leu Val
                  20                  25                  30

 His Ser Asn Gly Asn Thr Tyr Leu Glu Trp Tyr Gln Gln Lys Pro
                  35                  40                  45

 Gly Lys Ala Pro Lys Leu Leu Ile Tyr Arg Val Ser Asn Arg Phe
                  50                  55                  60

 Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp
                  65                  70                  75

 Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr
                  80                  85                  90

 Tyr Tyr Cys Phe Gln Gly Ser Phe Asn Pro Leu Thr Phe Gly Gln
                  95                 100                 105

 Gly Thr Lys Val Glu Ile Lys Arg
                 110            

<210> 7
<211> 113
<212> PRT
<213> Homo sapiens

<400> 7
 Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val
   1               5                  10                  15

 Gly Asp Arg Val Thr Ile Thr Cys Arg Ser Ser Glu Thr Leu Val
                  20                  25                  30

 His Ser Ser Gly Asn Thr Tyr Leu Glu Trp Tyr Gln Gln Lys Pro
                  35                  40                  45

 Gly Lys Ala Pro Lys Leu Leu Ile Tyr Arg Val Ser Asn Arg Phe
                  50                  55                  60

 Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp
                  65                  70                  75

 Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr
                  80                  85                  90

 Tyr Tyr Cys Phe Gln Gly Ser Phe Asn Pro Leu Thr Phe Gly Gln
                  95                 100                 105

 Gly Thr Lys Val Glu Ile Lys Arg
                 110            

<210> 8
<211> 113
<212> PRT
<213> Homo sapiens

<400> 8
 Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val
   1               5                  10                  15

 Gly Asp Arg Val Thr Ile Thr Cys Arg Ser Ser Glu Thr Leu Val
                  20                  25                  30

 His Ser Ser Gly Asn Thr Tyr Leu Glu Trp Tyr Gln Gln Lys Pro
                  35                  40                  45

 Gly Lys Ala Pro Lys Leu Leu Ile Tyr Arg Val Ser Asn Arg Phe
                  50                  55                  60

 Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp
                  65                  70                  75

 Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr
                  80                  85                  90

 Tyr Tyr Cys Phe Gln Gly Ser Phe Asn Pro Leu Thr Phe Gly Gln
                  95                 100                 105

 Gly Thr Lys Val Glu Ile Lys Arg
                 110            

<210> 9
<211> 113
<212> PRT
<213> Homo sapiens

<400> 9
 Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val
   1               5                  10                  15

 Gly Asp Arg Val Thr Ile Thr Cys Arg Ser Ser Glu Thr Leu Val
                  20                  25                  30

 His Ser Ser Gly Asn Thr Tyr Leu Glu Trp Tyr Gln Gln Lys Pro
                  35                  40                  45

 Gly Lys Ala Pro Lys Leu Leu Ile Tyr Arg Val Ser Asn Arg Phe
                  50                  55                  60

 Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp
                  65                  70                  75

 Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr
                  80                  85                  90

 Tyr Tyr Cys Phe Gln Gly Ser Phe Asn Pro Leu Thr Phe Gly Gln
                  95                 100                 105

 Gly Thr Lys Val Glu Ile Lys Arg
                 110            

<210> 10
<211> 113
<212> PRT
<213> Homo sapiens

<400> 10
 Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val
   1               5                  10                  15

 Gly Asp Arg Val Thr Ile Thr Cys Arg Ser Ser Glu Thr Leu Val
                  20                  25                  30

 His Trp Ser Gly Asn Thr Tyr Leu Glu Trp Tyr Gln Gln Lys Pro
                  35                  40                  45

 Gly Lys Ala Pro Lys Leu Leu Ile Tyr Arg Val Ser Asn Arg Phe
                  50                  55                  60

 Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp
                  65                  70                  75

 Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr
                  80                  85                  90

 Tyr Tyr Cys Phe Gln Gly Ser Phe Asn Pro Leu Thr Phe Gly Gln
                  95                 100                 105

 Gly Thr Lys Val Glu Ile Lys Arg
                 110            

<210> 11
<211> 113
<212> PRT
<213> Homo sapiens

<400> 11
 Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val
   1               5                  10                  15

 Gly Asp Arg Val Thr Ile Thr Cys Arg Ser Ser Gly Thr Leu Arg
                  20                  25                  30

 His Trp Ser Gly Asn Thr Tyr Leu Glu Trp Tyr Gln Gln Lys Pro
                  35                  40                  45

 Gly Lys Ala Pro Lys Leu Leu Ile Tyr Arg Val Ser Asn Arg Phe
                  50                  55                  60

 Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp
                  65                  70                  75

 Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr
                  80                  85                  90

 Tyr Tyr Cys Phe Gln Gly Ser Phe Asn Pro Leu Thr Phe Gly Gln
                  95                 100                 105

 Gly Thr Lys Val Glu Ile Lys Arg
                 110            

<210> 12
<211> 113
<212> PRT
<213> Homo sapiens

<400> 12
 Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly
   1               5                  10                  15

 Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser
                  20                  25                  30

 Ser Tyr Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu
                  35                  40                  45

 Glu Trp Val Ser Val Ile Ser Gly Asp Gly Gly Ser Thr Tyr Tyr
                  50                  55                  60

 Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser
                  65                  70                  75

 Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp
                  80                  85                  90

 Thr Ala Val Tyr Tyr Cys Ala Arg Gly Phe Asp Tyr Trp Gly Gln
                  95                 100                 105

 Gly Thr Leu Val Thr Val Ser Ser
                 110            

<210> 13
<211> 120
<212> PRT
<213> Homo sapiens

<400> 13
 Glu Val Met Leu Val Glu Ser Gly Gly Gly Leu Val Arg Pro Gly
   1               5                  10                  15

 Gly Ser Leu Lys Val Ser Cys Ala Ala Ser Gly Phe Ser Phe Ser
                  20                  25                  30

 Asp Phe Ala Met Ser Trp Val Arg Arg Thr Pro Asp Lys Arg Leu
                  35                  40                  45

 Glu Trp Val Ala Thr Ile Gly Arg Val Ala Ser His Thr Tyr Tyr
                  50                  55                  60

 Pro Asp Ser Met Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala
                  65                  70                  75

 Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ser Asp Asp
                  80                  85                  90

 Thr Ala Ile Tyr Tyr Cys Val Arg His Arg Gly Phe Asp Val Gly
                  95                 100                 105

 His Phe Asp Phe Trp Gly Gln Gly Thr Leu Leu Thr Val Ser Ala
                 110                 115                 120

<210> 14
<211> 120
<212> PRT
<213> Homo sapiens

<400> 14
 Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly
   1               5                  10                  15

 Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ser Phe Ser
                  20                  25                  30

 Asp Phe Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu
                  35                  40                  45

 Glu Trp Val Ala Thr Ile Gly Arg Val Ala Ser His Thr Tyr Tyr
                  50                  55                  60

 Pro Asp Ser Met Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser
                  65                  70                  75

 Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp
                  80                  85                  90

 Thr Ala Val Tyr Tyr Cys Val Arg His Arg Gly Phe Asp Val Gly
                  95                 100                 105

 His Phe Asp Phe Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser
                 110                 115                 120

<210> 15
<211> 120
<212> PRT
<213> Homo sapiens

<400> 15
 Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly
   1               5                  10                  15

 Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ser Phe Ser
                  20                  25                  30

 Asp Phe Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu
                  35                  40                  45

 Glu Trp Val Ala Thr Ile Gly Arg Val Ala Ser His Thr Tyr Tyr
                  50                  55                  60

 Pro Asp Ser Met Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser
                  65                  70                  75

 Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp
                  80                  85                  90

 Thr Ala Val Tyr Tyr Cys Val Arg His Arg Gly Phe Asp Val Gly
                  95                 100                 105

 His Phe Asp Phe Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser
                 110                 115                 120

<210> 16
<211> 120
<212> PRT
<213> Homo sapiens

<400> 16
 Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly
   1               5                  10                  15

 Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ser Phe Ser
                  20                  25                  30

 Asp Phe Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu
                  35                  40                  45

 Glu Trp Val Ala Thr Ile Gly Arg Val Ala Ser His Thr Tyr Tyr
                  50                  55                  60

 Pro Asp Ser Met Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser
                  65                  70                  75

 Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp
                  80                  85                  90

 Thr Ala Val Tyr Tyr Cys Val Arg His Arg Gly Phe Asp Val Gly
                  95                 100                 105

 His Phe Asp Phe Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser
                 110                 115                 120

<210> 17
<211> 120
<212> PRT
<213> Homo sapiens

<400> 17
 Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly
   1               5                  10                  15

 Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ser Phe Ser
                  20                  25                  30

 Asp Phe Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu
                  35                  40                  45

 Glu Trp Val Ala Thr Ile Gly Arg Val Ser Phe His Thr Tyr Tyr
                  50                  55                  60

 Pro Val Ser Met Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser
                  65                  70                  75

 Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp
                  80                  85                  90

 Thr Ala Val Tyr Tyr Cys Ala Arg His Arg Gly Phe Asp Val Gly
                  95                 100                 105

 His Phe Asp Phe Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser
                 110                 115                 120

<210> 18
<211> 120
<212> PRT
<213> Homo sapiens

<400> 18
 Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly
   1               5                  10                  15

 Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ser Phe Ser
                  20                  25                  30

 Asp Phe Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu
                  35                  40                  45

 Glu Trp Val Ala Thr Gly Phe Ser Phe Ser Asp Phe Ala Met Ser
                  50                  55                  60

 Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ala Thr
                  65                  70                  75

 Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp
                  80                  85                  90

 Thr Ala Val Tyr Tyr Cys Ala Arg His Arg Gly Phe Asp Val Gly
                  95                 100                 105

 His Phe Asp Phe Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser
                 110                 115                 120

<210> 19
<211> 120
<212> PRT
<213> Homo sapiens

<400> 19
 Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly
   1               5                  10                  15

 Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ser Phe Ser
                  20                  25                  30

 Asp Phe Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu
                  35                  40                  45

 Glu Trp Val Ala Thr Ile Gly Arg Val Ala Ser His Thr Tyr Tyr
                  50                  55                  60

 Pro Asp Ser Met Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser
                  65                  70                  75

 Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp
                  80                  85                  90

 Thr Ala Val Tyr Tyr Cys Ala Arg His Arg Gly Phe Asp Val Gly
                  95                 100                 105

 His Phe Asp Phe Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser
                 110                 115                 120

<210> 20
<211> 95
<212> PRT
<213> Homo sapiens

<400> 20
 Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly
   1               5                  10                  15

 Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Ile Gly Arg Val Ala
                  20                  25                  30

 Ser His Thr Tyr Tyr Pro Asp Ser Met Lys Gly Arg Phe Thr Ile
                  35                  40                  45

 Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser
                  50                  55                  60

 Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg His Arg
                  65                  70                  75

 Gly Phe Asp Val Gly His Phe Asp Phe Trp Gly Gln Gly Thr Leu
                  80                  85                  90

 Val Thr Val Ser Ser
                  95

<210> 21
<211> 11
<212> PRT
<213> Homo sapiens

<400> 21
 Arg Ala Ser Gln Ser Ile Ser Asn Tyr Leu Ala
   1               5                  10    

<210> 22
<211> 16
<212> PRT
<213> Homo sapiens

<400> 22
 Arg Ser Ser Glu Thr Leu Val His Ser Asn Gly Asn Thr Tyr Leu
   1               5                  10                  15

 Glu
    

<210> 23
<211> 16
<212> PRT
<213> Homo sapiens

<400> 23
 Arg Ser Ser Glu Thr Leu Val His Ser Ser Gly Asn Thr Tyr Leu
   1               5                  10                  15

 Glu
    

<210> 24
<211> 16
<212> PRT
<213> Homo sapiens

<400> 24
 Arg Ser Ser Glu Thr Leu Val His Trp Ser Gly Asn Thr Tyr Leu
   1               5                  10                  15

 Glu
    

<210> 25
<211> 16
<212> PRT
<213> Homo sapiens

<400> 25
 Arg Ser Ser Gly Thr Leu Arg His Trp Ser Gly Asn Thr Tyr Leu
   1               5                  10                  15

 Glu
    

<210> 26
<211> 16
<212> PRT
<213> Homo sapiens

<400> 26
 Arg Ser Ser Gly Thr Leu Leu His Asn Asn Gly Asn Thr Tyr Leu
   1               5                  10                  15

 Glu
    

<210> 27
<211> 16
<212> PRT
<213> Homo sapiens

<400> 27
 Arg Ser Ser Glu Thr Leu Val His Arg Ser Gly Asn Thr Tyr Leu
   1               5                  10                  15

 Glu
    

<210> 28
<211> 16
<212> PRT
<213> Homo sapiens

<400> 28
 Arg Ser Ser Glu Thr Leu Val His Thr Ser Gly Asn Thr Tyr Leu
   1               5                  10                  15

 Glu
    

<210> 29
<211> 16
<212> PRT
<213> Homo sapiens

<400> 29
 Arg Ser Ser Glu Thr Leu Val His Gly Ser Gly Asn Thr Tyr Leu
   1               5                  10                  15

 Glu
    

<210> 30
<211> 16
<212> PRT
<213> Homo sapiens

<400> 30
 Arg Ser Ser Glu Thr Leu Val His Ala Ser Gly Asn Thr Tyr Leu
   1               5                  10                  15

 Glu
    

<210> 31
<211> 16
<212> PRT
<213> Homo sapiens

<400> 31
 Arg Ser Ser Glu Thr Leu Val His Asn Ser Gly Asn Thr Tyr Leu
   1               5                  10                  15

 Glu
    

<210> 32
<211> 16
<212> PRT
<213> Homo sapiens

<400> 32
 Arg Ser Ser Glu Thr Leu Val His Lys Ser Gly Asn Thr Tyr Leu
   1               5                  10                  15

 Glu
    

<210> 33
<211> 16
<212> PRT
<213> Homo sapiens

<400> 33
 Arg Ser Ser Arg Thr Leu Glu His Ala Ser Gly Asn Thr Tyr Leu
   1               5                  10                  15

 Glu
    

<210> 34
<211> 16
<212> PRT
<213> Homo sapiens

<400> 34
 Arg Ser Ser Gln Thr Leu Gln His Trp Ser Gly Asn Thr Tyr Leu
   1               5                  10                  15

 Glu
    

<210> 35
<211> 7
<212> PRT
<213> Homo sapiens

<400> 35
 Ala Ala Ser Ser Leu Glu Ser
   1               5        

<210> 36
<211> 7
<212> PRT
<213> Homo sapiens

<400> 36
 Arg Val Ser Asn Arg Phe Ser
   1               5        

<210> 37
<211> 7
<212> PRT
<213> Homo sapiens

<400> 37
 Arg Val Ser Gln Arg Phe Thr
   1               5        

<210> 38
<211> 7
<212> PRT
<213> Homo sapiens

<400> 38
 Arg Val Ser Asn Arg Phe Arg
   1               5        

<210> 39
<211> 9
<212> PRT
<213> Homo sapiens

<400> 39
 Gln Gln Tyr Asn Ser Leu Pro Trp Thr
   1               5                

<210> 40
<211> 9
<212> PRT
<213> Homo sapiens

<400> 40
 Phe Gln Gly Ser His Asn Pro Leu Thr
   1               5                

<210> 41
<211> 9
<212> PRT
<213> Homo sapiens

<400> 41
 Phe Gln Gly Ser Phe Asn Pro Leu Thr
   1               5                

<210> 42
<211> 10
<212> PRT
<213> Homo sapiens

<400> 42
 Gly Phe Thr Phe Ser Ser Tyr Ala Met Ser
   1               5                  10

<210> 43
<211> 10
<212> PRT
<213> Homo sapiens

<400> 43
 Gly Phe Ser Phe Ser Asp Phe Ala Met Ser
   1               5                  10

<210> 44
<211> 10
<212> PRT
<213> Homo sapiens

<400> 44
 Ser Ser Ser Phe Ser Asp Phe Ala Leu Ser
   1               5                  10

<210> 45
<211> 10
<212> PRT
<213> Homo sapiens

<400> 45
 Gly Phe Asn Phe Arg Gly Phe Ala Met Ser
   1               5                  10

<210> 46
<211> 18
<212> PRT
<213> Homo sapiens

<400> 46
 Ser Val Ile Ser Gly Asp Gly Gly Ser Thr Tyr Tyr Ala Asp Ser
   1               5                  10                  15

 Val Lys Gly
            

<210> 47
<211> 18
<212> PRT
<213> Homo sapiens

<400> 47
 Ala Thr Ile Gly Arg Val Ala Ser His Thr Tyr Tyr Pro Asp Ser
   1               5                  10                  15

 Met Lys Gly
            

<210> 48
<211> 18
<212> PRT
<213> Homo sapiens

<400> 48
 Ala Thr Ile Gly Arg Val Ser Phe His Thr Tyr Tyr Pro Val Ser
   1               5                  10                  15

 Met Lys Gly
            

<210> 49
<211> 18
<212> PRT
<213> Homo sapiens

<400> 49
 Ala Thr Ile Gly Arg Val Ala Phe His Thr Tyr Tyr Pro Asp Ser
   1               5                  10                  15

 Met Lys Gly
            

<210> 50
<211> 18
<212> PRT
<213> Homo sapiens

<400> 50
 Ser Thr Ile Gly Arg Val Ala Ser His Thr Tyr Tyr Pro Val Gly
   1               5                  10                  15

 Met Thr Gly
            

<210> 51
<211> 18
<212> PRT
<213> Homo sapiens

<400> 51
 Ala Thr Ile Gly Arg Val Trp Tyr His Arg Tyr Tyr Pro Asp Ser
   1               5                  10                  15

 Met Val Arg
            

<210> 52
<211> 18
<212> PRT
<213> Homo sapiens

<400> 52
 Gly Thr Ile Gly Trp Met Val Ser His Thr Tyr Tyr Pro Gln Arg
   1               5                  10                  15

 Leu Asn Gly
            

<210> 53
<211> 18
<212> PRT
<213> Homo sapiens

<400> 53
 Ala Thr Ile Gly Arg Val Thr Ser Arg Thr Tyr Tyr Pro Asp Ser
   1               5                  10                  15

 Met Lys Gly
            

<210> 54
<211> 18
<212> PRT
<213> Homo sapiens

<400> 54
 Ala Thr Ile Gly Arg Val Tyr Arg His Thr Tyr Tyr Pro Thr Ser
   1               5                  10                  15

 Met Lys Gly
            

<210> 55
<211> 18
<212> PRT
<213> Homo sapiens

<400> 55
 Ala Thr Ile Gly Arg Val Pro Leu His Thr Tyr Tyr Pro Arg Ser
   1               5                  10                  15

 Met Lys Gly
            

<210> 56
<211> 18
<212> PRT
<213> Homo sapiens

<400> 56
 Ala Thr Ile Gly Arg Val Pro Leu His Thr Tyr Tyr Pro Gly Ser
   1               5                  10                  15

 Met Lys Gly
            

<210> 57
<211> 18
<212> PRT
<213> Homo sapiens

<400> 57
 Ala Thr Ile Gly Arg Val Pro Leu His Thr Tyr Tyr Pro Ala Ser
   1               5                  10                  15

 Met Lys Gly
            

<210> 58
<211> 18
<212> PRT
<213> Homo sapiens

<400> 58
 Ala Thr Ile Gly Arg Val Glu Gln His Thr Tyr Tyr Pro Gln Ser
   1               5                  10                  15

 Met Lys Gly
            

<210> 59
<211> 18
<212> PRT
<213> Homo sapiens

<400> 59
 Ala Thr Ile Gly Arg Val Ala Ser His Thr Tyr Tyr Pro Gly Ser
   1               5                  10                  15

 Met Lys Gly
            

<210> 60
<211> 18
<212> PRT
<213> Homo sapiens

<400> 60
 Ala Thr Ile Gly Arg Val Ala Leu His Thr Tyr Tyr Pro Gln Ser
   1               5                  10                  15

 Met Lys Gly
            

<210> 61
<211> 6
<212> PRT
<213> Homo sapiens

<400> 61
 Ala Arg Gly Phe Asp Tyr
   1               5    

<210> 62
<211> 13
<212> PRT
<213> Homo sapiens

<400> 62
 Val Arg His Arg Gly Phe Asp Val Gly His Phe Asp Phe
   1               5                  10            

<210> 63
<211> 13
<212> PRT
<213> Homo sapiens

<400> 63
 Ala Arg His Arg Gly Phe Asp Val Gly His Phe Val Phe
   1               5                  10            

<210> 64
<211> 13
<212> PRT
<213> Homo sapiens

<400> 64
 Ala Arg His Arg Gly Trp Val Val Gly His Phe Asp Leu
   1               5                  10            

<210> 65
<211> 13
<212> PRT
<213> Homo sapiens

<400> 65
 Ala Arg His Arg Gly Phe Asp Val Gly His Phe Asp Phe
   1               5                  10            

<210> 66
<211> 87
<212> PRT
<213> Homo sapiens

<400> 66
 Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly
   1               5                  10                  15

 Ala Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr
                  20                  25                  30

 Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met Gly Arg
                  35                  40                  45

 Val Thr Ile Thr Ala Asp Thr Ser Thr Ser Thr Ala Tyr Met Glu
                  50                  55                  60

 Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys Ala
                  65                  70                  75

 Arg Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser
                  80                  85        

<210> 67
<211> 81
<212> PRT
<213> Homo sapiens

<400> 67
 Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly
   1               5                  10                  15

 Ala Ser Val Lys Val Ser Cys Lys Ala Ser Trp Val Arg Gln Ala
                  20                  25                  30

 Pro Gly Gln Gly Leu Glu Trp Met Arg Val Thr Ile Thr Ala Asp
                  35                  40                  45

 Thr Ser Thr Ser Thr Ala Tyr Met Glu Leu Ser Ser Leu Arg Ser
                  50                  55                  60

 Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg Trp Gly Gln Gly Thr
                  65                  70                  75

 Leu Val Thr Val Ser Ser
                  80    

<210> 68
<211> 80
<212> PRT
<213> Homo sapiens

<400> 68
 Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly
   1               5                  10                  15

 Ala Ser Val Lys Val Ser Cys Lys Ala Ser Trp Val Arg Gln Ala
                  20                  25                  30

 Pro Gly Gln Gly Leu Glu Trp Met Arg Val Thr Ile Thr Ala Asp
                  35                  40                  45

 Thr Ser Thr Ser Thr Ala Tyr Met Glu Leu Ser Ser Leu Arg Ser
                  50                  55                  60

 Glu Asp Thr Ala Val Tyr Tyr Cys Ala Trp Gly Gln Gly Thr Leu
                  65                  70                  75

 Val Thr Val Ser Ser
                  80

<210> 69
<211> 79
<212> PRT
<213> Homo sapiens

<400> 69
 Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly
   1               5                  10                  15

 Ala Ser Val Lys Val Ser Cys Lys Ala Ser Trp Val Arg Gln Ala
                  20                  25                  30

 Pro Gly Gln Gly Leu Glu Trp Met Arg Val Thr Ile Thr Ala Asp
                  35                  40                  45

 Thr Ser Thr Ser Thr Ala Tyr Met Glu Leu Ser Ser Leu Arg Ser
                  50                  55                  60

 Glu Asp Thr Ala Val Tyr Tyr Cys Trp Gly Gln Gly Thr Leu Val
                  65                  70                  75

 Thr Val Ser Ser
                

<210> 70
<211> 87
<212> PRT
<213> Homo sapiens

<400> 70
 Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser
   1               5                  10                  15

 Gln Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Gly Ser Val Ser
                  20                  25                  30

 Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile Gly Arg
                  35                  40                  45

 Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe Ser Leu Lys
                  50                  55                  60

 Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala
                  65                  70                  75

 Arg Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser
                  80                  85        

<210> 71
<211> 81
<212> PRT
<213> Homo sapiens

<400> 71
 Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser
   1               5                  10                  15

 Gln Thr Leu Ser Leu Thr Cys Thr Val Ser Trp Ile Arg Gln Pro
                  20                  25                  30

 Pro Gly Lys Gly Leu Glu Trp Ile Arg Val Thr Ile Ser Val Asp
                  35                  40                  45

 Thr Ser Lys Asn Gln Phe Ser Leu Lys Leu Ser Ser Val Thr Ala
                  50                  55                  60

 Ala Asp Thr Ala Val Tyr Tyr Cys Ala Arg Trp Gly Gln Gly Thr
                  65                  70                  75

 Leu Val Thr Val Ser Ser
                  80    

<210> 72
<211> 80
<212> PRT
<213> Homo sapiens

<400> 72
 Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser
   1               5                  10                  15

 Gln Thr Leu Ser Leu Thr Cys Thr Val Ser Trp Ile Arg Gln Pro
                  20                  25                  30

 Pro Gly Lys Gly Leu Glu Trp Ile Arg Val Thr Ile Ser Val Asp
                  35                  40                  45

 Thr Ser Lys Asn Gln Phe Ser Leu Lys Leu Ser Ser Val Thr Ala
                  50                  55                  60

 Ala Asp Thr Ala Val Tyr Tyr Cys Ala Trp Gly Gln Gly Thr Leu
                  65                  70                  75

 Val Thr Val Ser Ser
                  80

<210> 73
<211> 79
<212> PRT
<213> Homo sapiens

<400> 73
 Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser
   1               5                  10                  15

 Gln Thr Leu Ser Leu Thr Cys Thr Val Ser Trp Ile Arg Gln Pro
                  20                  25                  30

 Pro Gly Lys Gly Leu Glu Trp Ile Arg Val Thr Ile Ser Val Asp
                  35                  40                  45

 Thr Ser Lys Asn Gln Phe Ser Leu Lys Leu Ser Ser Val Thr Ala
                  50                  55                  60

 Ala Asp Thr Ala Val Tyr Tyr Cys Trp Gly Gln Gly Thr Leu Val
                  65                  70                  75

 Thr Val Ser Ser
                

<210> 74
<211> 79
<212> PRT
<213> Homo sapiens

<400> 74
 Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly
   1               5                  10                  15

 Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Trp Val Arg Gln Ala
                  20                  25                  30

 Pro Gly Lys Gly Leu Glu Trp Val Arg Phe Thr Ile Ser Arg Asp
                  35                  40                  45

 Asn Ser Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala
                  50                  55                  60

 Glu Asp Thr Ala Val Tyr Tyr Cys Trp Gly Gln Gly Thr Leu Val
                  65                  70                  75

 Thr Val Ser Ser
                

<210> 75
<211> 79
<212> PRT
<213> Homo sapiens

<400> 75
 Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly
   1               5                  10                  15

 Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Trp Val Arg Gln Ala
                  20                  25                  30

 Pro Gly Lys Gly Leu Glu Trp Val Arg Phe Thr Ile Ser Arg Asp
                  35                  40                  45

 Asn Ser Lys Asn Thr Phe Tyr Leu Gln Met Asn Ser Leu Arg Ala
                  50                  55                  60

 Glu Asp Thr Ala Val Tyr Tyr Cys Trp Gly Gln Gly Thr Leu Val
                  65                  70                  75

 Thr Val Ser Ser
                

<210> 76
<211> 80
<212> PRT
<213> Homo sapiens

<400> 76
 Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val
   1               5                  10                  15

 Gly Asp Arg Val Thr Ile Thr Cys Trp Tyr Gln Gln Lys Pro Gly
                  20                  25                  30

 Lys Ala Pro Lys Leu Leu Ile Gly Val Pro Ser Arg Phe Ser Gly
                  35                  40                  45

 Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln
                  50                  55                  60

 Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Phe Gly Gln Gly Thr Lys
                  65                  70                  75

 Val Glu Ile Lys Arg
                  80

<210> 77
<211> 80
<212> PRT
<213> Homo sapiens

<400> 77
 Asp Ile Val Met Thr Gln Ser Pro Leu Ser Leu Pro Val Thr Pro
   1               5                  10                  15

 Gly Glu Pro Ala Ser Ile Ser Cys Trp Tyr Leu Gln Lys Pro Gly
                  20                  25                  30

 Gln Ser Pro Gln Leu Leu Ile Tyr Gly Val Pro Asp Arg Phe Ser
                  35                  40                  45

 Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile Ser Arg Val
                  50                  55                  60

 Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Phe Gly Gln Gly Thr
                  65                  70                  75

 Lys Val Glu Ile Lys
                  80

<210> 78
<211> 80
<212> PRT
<213> Homo sapiens

<400> 78
 Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro
   1               5                  10                  15

 Gly Glu Arg Ala Thr Leu Ser Cys Trp Tyr Gln Gln Lys Pro Gly
                  20                  25                  30

 Gln Ala Pro Arg Leu Leu Ile Tyr Gly Ile Pro Asp Arg Phe Ser
                  35                  40                  45

 Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu
                  50                  55                  60

 Glu Pro Glu Asp Phe Ala Val Tyr Tyr Cys Phe Gly Gln Gly Thr
                  65                  70                  75

 Lys Val Glu Ile Lys
                  80

<210> 79
<211> 80
<212> PRT
<213> Homo sapiens

<400> 79
 Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu
   1               5                  10                  15

 Gly Glu Arg Ala Thr Ile Asn Cys Trp Tyr Gln Gln Lys Pro Gly
                  20                  25                  30

 Gln Pro Pro Lys Leu Leu Ile Tyr Gly Val Pro Asp Arg Phe Ser
                  35                  40                  45

 Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu
                  50                  55                  60

 Gln Ala Glu Asp Val Ala Val Tyr Tyr Cys Phe Gly Gln Gly Thr
                  65                  70                  75

 Lys Val Glu Ile Lys
                  80

<210> 80
<211> 449
<212> PRT
<213> Homo sapiens

<400> 80
 Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly
   1               5                  10                  15

 Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ser Phe Ser
                  20                  25                  30

 Asp Phe Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu
                  35                  40                  45

 Glu Trp Val Ala Thr Ile Gly Arg Val Ala Phe His Thr Tyr Tyr
                  50                  55                  60

 Pro Asp Ser Met Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser
                  65                  70                  75

 Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp
                  80                  85                  90

 Thr Ala Val Tyr Tyr Cys Ala Arg His Arg Gly Phe Asp Val Gly
                  95                 100                 105

 His Phe Asp Phe Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser
                 110                 115                 120

 Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser
                 125                 130                 135

 Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys
                 140                 145                 150

 Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala
                 155                 160                 165

 Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser
                 170                 175                 180

 Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser
                 185                 190                 195

 Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser
                 200                 205                 210

 Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys
                 215                 220                 225

 Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly
                 230                 235                 240

 Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met
                 245                 250                 255

 Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser
                 260                 265                 270

 His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val
                 275                 280                 285

 Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn
                 290                 295                 300

 Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp
                 305                 310                 315

 Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala
                 320                 325                 330

 Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln
                 335                 340                 345

 Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu
                 350                 355                 360

 Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe
                 365                 370                 375

 Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro
                 380                 385                 390

 Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly
                 395                 400                 405

 Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp
                 410                 415                 420

 Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu
                 425                 430                 435

 His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly
                 440                 445                

<210> 81
<211> 219
<212> PRT
<213> Homo sapiens

<400> 81
 Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val
   1               5                  10                  15

 Gly Asp Arg Val Thr Ile Thr Cys Arg Ser Ser Glu Thr Leu Val
                  20                  25                  30

 His Ser Ser Gly Asn Thr Tyr Leu Glu Trp Tyr Gln Gln Lys Pro
                  35                  40                  45

 Gly Lys Ala Pro Lys Leu Leu Ile Tyr Arg Val Ser Asn Arg Phe
                  50                  55                  60

 Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp
                  65                  70                  75

 Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr
                  80                  85                  90

 Tyr Tyr Cys Phe Gln Gly Ser Phe Asn Pro Leu Thr Phe Gly Gln
                  95                 100                 105

 Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala Ala Pro Ser Val
                 110                 115                 120

 Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly Thr Ala
                 125                 130                 135

 Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala Lys
                 140                 145                 150

 Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln
                 155                 160                 165

 Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu
                 170                 175                 180

 Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys
                 185                 190                 195

 Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val
                 200                 205                 210

 Thr Lys Ser Phe Asn Arg Gly Glu Cys
                 215                

