                         SEQUENCE LISTING

<110>  Butamax (TM) Advanced Biofuels
 
<120>  METHOD FOR PRODUCING BUTANOL USING EXTRACTIVE FERMENTATION WITH 
       ELECTROLYTE ADDITION

<130>  CL4574

<150>  US 61/263,519
<151>  2009-11-23

<160>  95    

<170>  PatentIn version 3.5

<210>  1
<211>  1680
<212>  DNA
<213>  Klebsiella pneumoniae

<400>  1
atggacaaac agtatccggt acgccagtgg gcgcacggcg ccgatctcgt cgtcagtcag       60

ctggaagctc agggagtacg ccaggtgttc ggcatccccg gcgccaaaat cgacaaggtc      120

tttgattcac tgctggattc ctccattcgc attattccgg tacgccacga agccaacgcc      180

gcatttatgg ccgccgccgt cggacgcatt accggcaaag cgggcgtggc gctggtcacc      240

tccggtccgg gctgttccaa cctgatcacc ggcatggcca ccgcgaacag cgaaggcgac      300

ccggtggtgg ccctgggcgg cgcggtaaaa cgcgccgata aagcgaagca ggtccaccag      360

agtatggata cggtggcgat gttcagcccg gtcaccaaat acgccatcga ggtgacggcg      420

ccggatgcgc tggcggaagt ggtctccaac gccttccgcg ccgccgagca gggccggccg      480

ggcagcgcgt tcgttagcct gccgcaggat gtggtcgatg gcccggtcag cggcaaagtg      540

ctgccggcca gcggggcccc gcagatgggc gccgcgccgg atgatgccat cgaccaggtg      600

gcgaagctta tcgcccaggc gaagaacccg atcttcctgc tcggcctgat ggccagccag      660

ccggaaaaca gcaaggcgct gcgccgtttg ctggagacca gccatattcc agtcaccagc      720

acctatcagg ccgccggagc ggtgaatcag gataacttct ctcgcttcgc cggccgggtt      780

gggctgttta acaaccaggc cggggaccgt ctgctgcagc tcgccgacct ggtgatctgc      840

atcggctaca gcccggtgga atacgaaccg gcgatgtgga acagcggcaa cgcgacgctg      900

gtgcacatcg acgtgctgcc cgcctatgaa gagcgcaact acaccccgga tgtcgagctg      960

gtgggcgata tcgccggcac tctcaacaag ctggcgcaaa atatcgatca tcggctggtg     1020

ctctccccgc aggcggcgga gatcctccgc gaccgccagc accagcgcga gctgctggac     1080

cgccgcggcg cgcagctcaa ccagtttgcc ctgcatcccc tgcgcatcgt tcgcgccatg     1140

caggatatcg tcaacagcga cgtcacgttg accgtggaca tgggcagctt ccatatctgg     1200

attgcccgct acctgtacac gttccgcgcc cgtcaggtga tgatctccaa cggccagcag     1260

accatgggcg tcgccctgcc ctgggctatc ggcgcctggc tggtcaatcc tgagcgcaaa     1320

gtggtctccg tctccggcga cggcggcttc ctgcagtcga gcatggagct ggagaccgcc     1380

gtccgcctga aagccaacgt gctgcatctt atctgggtcg ataacggcta caacatggtc     1440

gctatccagg aagagaaaaa atatcagcgc ctgtccggcg tcgagtttgg gccgatggat     1500

tttaaagcct atgccgaatc cttcggcgcg aaagggtttg ccgtggaaag cgccgaggcg     1560

ctggagccga ccctgcgcgc ggcgatggac gtcgacggcc cggcggtagt ggccatcccg     1620

gtggattatc gcgataaccc gctgctgatg ggccagctgc atctgagtca gattctgtaa     1680


<210>  2
<211>  559
<212>  PRT
<213>  Klebsiella pneumoniae

<400>  2

Met Asp Lys Gln Tyr Pro Val Arg Gln Trp Ala His Gly Ala Asp Leu 
1               5                   10                  15      


Val Val Ser Gln Leu Glu Ala Gln Gly Val Arg Gln Val Phe Gly Ile 
            20                  25                  30          


Pro Gly Ala Lys Ile Asp Lys Val Phe Asp Ser Leu Leu Asp Ser Ser 
        35                  40                  45              


Ile Arg Ile Ile Pro Val Arg His Glu Ala Asn Ala Ala Phe Met Ala 
    50                  55                  60                  


Ala Ala Val Gly Arg Ile Thr Gly Lys Ala Gly Val Ala Leu Val Thr 
65                  70                  75                  80  


Ser Gly Pro Gly Cys Ser Asn Leu Ile Thr Gly Met Ala Thr Ala Asn 
                85                  90                  95      


Ser Glu Gly Asp Pro Val Val Ala Leu Gly Gly Ala Val Lys Arg Ala 
            100                 105                 110         


Asp Lys Ala Lys Gln Val His Gln Ser Met Asp Thr Val Ala Met Phe 
        115                 120                 125             


Ser Pro Val Thr Lys Tyr Ala Ile Glu Val Thr Ala Pro Asp Ala Leu 
    130                 135                 140                 


Ala Glu Val Val Ser Asn Ala Phe Arg Ala Ala Glu Gln Gly Arg Pro 
145                 150                 155                 160 


Gly Ser Ala Phe Val Ser Leu Pro Gln Asp Val Val Asp Gly Pro Val 
                165                 170                 175     


Ser Gly Lys Val Leu Pro Ala Ser Gly Ala Pro Gln Met Gly Ala Ala 
            180                 185                 190         


Pro Asp Asp Ala Ile Asp Gln Val Ala Lys Leu Ile Ala Gln Ala Lys 
        195                 200                 205             


Asn Pro Ile Phe Leu Leu Gly Leu Met Ala Ser Gln Pro Glu Asn Ser 
    210                 215                 220                 


Lys Ala Leu Arg Arg Leu Leu Glu Thr Ser His Ile Pro Val Thr Ser 
225                 230                 235                 240 


Thr Tyr Gln Ala Ala Gly Ala Val Asn Gln Asp Asn Phe Ser Arg Phe 
                245                 250                 255     


Ala Gly Arg Val Gly Leu Phe Asn Asn Gln Ala Gly Asp Arg Leu Leu 
            260                 265                 270         


Gln Leu Ala Asp Leu Val Ile Cys Ile Gly Tyr Ser Pro Val Glu Tyr 
        275                 280                 285             


Glu Pro Ala Met Trp Asn Ser Gly Asn Ala Thr Leu Val His Ile Asp 
    290                 295                 300                 


Val Leu Pro Ala Tyr Glu Glu Arg Asn Tyr Thr Pro Asp Val Glu Leu 
305                 310                 315                 320 


Val Gly Asp Ile Ala Gly Thr Leu Asn Lys Leu Ala Gln Asn Ile Asp 
                325                 330                 335     


His Arg Leu Val Leu Ser Pro Gln Ala Ala Glu Ile Leu Arg Asp Arg 
            340                 345                 350         


Gln His Gln Arg Glu Leu Leu Asp Arg Arg Gly Ala Gln Leu Asn Gln 
        355                 360                 365             


Phe Ala Leu His Pro Leu Arg Ile Val Arg Ala Met Gln Asp Ile Val 
    370                 375                 380                 


Asn Ser Asp Val Thr Leu Thr Val Asp Met Gly Ser Phe His Ile Trp 
385                 390                 395                 400 


Ile Ala Arg Tyr Leu Tyr Thr Phe Arg Ala Arg Gln Val Met Ile Ser 
                405                 410                 415     


Asn Gly Gln Gln Thr Met Gly Val Ala Leu Pro Trp Ala Ile Gly Ala 
            420                 425                 430         


Trp Leu Val Asn Pro Glu Arg Lys Val Val Ser Val Ser Gly Asp Gly 
        435                 440                 445             


Gly Phe Leu Gln Ser Ser Met Glu Leu Glu Thr Ala Val Arg Leu Lys 
    450                 455                 460                 


Ala Asn Val Leu His Leu Ile Trp Val Asp Asn Gly Tyr Asn Met Val 
465                 470                 475                 480 


Ala Ile Gln Glu Glu Lys Lys Tyr Gln Arg Leu Ser Gly Val Glu Phe 
                485                 490                 495     


Gly Pro Met Asp Phe Lys Ala Tyr Ala Glu Ser Phe Gly Ala Lys Gly 
            500                 505                 510         


Phe Ala Val Glu Ser Ala Glu Ala Leu Glu Pro Thr Leu Arg Ala Ala 
        515                 520                 525             


Met Asp Val Asp Gly Pro Ala Val Val Ala Ile Pro Val Asp Tyr Arg 
    530                 535                 540                 


Asp Asn Pro Leu Leu Met Gly Gln Leu His Leu Ser Gln Ile Leu 
545                 550                 555                 


<210>  3
<211>  1476
<212>  DNA
<213>  Escherichia coli

<400>  3
atggctaact acttcaatac actgaatctg cgccagcagc tggcacagct gggcaaatgt       60

cgctttatgg gccgcgatga attcgccgat ggcgcgagct accttcaggg taaaaaagta      120

gtcatcgtcg gctgtggcgc acagggtctg aaccagggcc tgaacatgcg tgattctggt      180

ctcgatatct cctacgctct gcgtaaagaa gcgattgccg agaagcgcgc gtcctggcgt      240

aaagcgaccg aaaatggttt taaagtgggt acttacgaag aactgatccc acaggcggat      300

ctggtgatta acctgacgcc ggacaagcag cactctgatg tagtgcgcac cgtacagcca      360

ctgatgaaag acggcgcggc gctgggctac tcgcacggtt tcaacatcgt cgaagtgggc      420

gagcagatcc gtaaagatat caccgtagtg atggttgcgc cgaaatgccc aggcaccgaa      480

gtgcgtgaag agtacaaacg tgggttcggc gtaccgacgc tgattgccgt tcacccggaa      540

aacgatccga aaggcgaagg catggcgatt gccaaagcct gggcggctgc aaccggtggt      600

caccgtgcgg gtgtgctgga atcgtccttc gttgcggaag tgaaatctga cctgatgggc      660

gagcaaacca tcctgtgcgg tatgttgcag gctggctctc tgctgtgctt cgacaagctg      720

gtggaagaag gtaccgatcc agcatacgca gaaaaactga ttcagttcgg ttgggaaacc      780

atcaccgaag cactgaaaca gggcggcatc accctgatga tggaccgtct ctctaacccg      840

gcgaaactgc gtgcttatgc gctttctgaa cagctgaaag agatcatggc acccctgttc      900

cagaaacata tggacgacat catctccggc gaattctctt ccggtatgat ggcggactgg      960

gccaacgatg ataagaaact gctgacctgg cgtgaagaga ccggcaaaac cgcgtttgaa     1020

accgcgccgc agtatgaagg caaaatcggc gagcaggagt acttcgataa aggcgtactg     1080

atgattgcga tggtgaaagc gggcgttgaa ctggcgttcg aaaccatggt cgattccggc     1140

atcattgaag agtctgcata ttatgaatca ctgcacgagc tgccgctgat tgccaacacc     1200

atcgcccgta agcgtctgta cgaaatgaac gtggttatct ctgataccgc tgagtacggt     1260

aactatctgt tctcttacgc ttgtgtgccg ttgctgaaac cgtttatggc agagctgcaa     1320

ccgggcgacc tgggtaaagc tattccggaa ggcgcggtag ataacgggca actgcgtgat     1380

gtgaacgaag cgattcgcag ccatgcgatt gagcaggtag gtaagaaact gcgcggctat     1440

atgacagata tgaaacgtat tgctgttgcg ggttaa                               1476


<210>  4
<211>  491
<212>  PRT
<213>  Escherichia coli

<400>  4

Met Ala Asn Tyr Phe Asn Thr Leu Asn Leu Arg Gln Gln Leu Ala Gln 
1               5                   10                  15      


Leu Gly Lys Cys Arg Phe Met Gly Arg Asp Glu Phe Ala Asp Gly Ala 
            20                  25                  30          


Ser Tyr Leu Gln Gly Lys Lys Val Val Ile Val Gly Cys Gly Ala Gln 
        35                  40                  45              


Gly Leu Asn Gln Gly Leu Asn Met Arg Asp Ser Gly Leu Asp Ile Ser 
    50                  55                  60                  


Tyr Ala Leu Arg Lys Glu Ala Ile Ala Glu Lys Arg Ala Ser Trp Arg 
65                  70                  75                  80  


Lys Ala Thr Glu Asn Gly Phe Lys Val Gly Thr Tyr Glu Glu Leu Ile 
                85                  90                  95      


Pro Gln Ala Asp Leu Val Ile Asn Leu Thr Pro Asp Lys Gln His Ser 
            100                 105                 110         


Asp Val Val Arg Thr Val Gln Pro Leu Met Lys Asp Gly Ala Ala Leu 
        115                 120                 125             


Gly Tyr Ser His Gly Phe Asn Ile Val Glu Val Gly Glu Gln Ile Arg 
    130                 135                 140                 


Lys Asp Ile Thr Val Val Met Val Ala Pro Lys Cys Pro Gly Thr Glu 
145                 150                 155                 160 


Val Arg Glu Glu Tyr Lys Arg Gly Phe Gly Val Pro Thr Leu Ile Ala 
                165                 170                 175     


Val His Pro Glu Asn Asp Pro Lys Gly Glu Gly Met Ala Ile Ala Lys 
            180                 185                 190         


Ala Trp Ala Ala Ala Thr Gly Gly His Arg Ala Gly Val Leu Glu Ser 
        195                 200                 205             


Ser Phe Val Ala Glu Val Lys Ser Asp Leu Met Gly Glu Gln Thr Ile 
    210                 215                 220                 


Leu Cys Gly Met Leu Gln Ala Gly Ser Leu Leu Cys Phe Asp Lys Leu 
225                 230                 235                 240 


Val Glu Glu Gly Thr Asp Pro Ala Tyr Ala Glu Lys Leu Ile Gln Phe 
                245                 250                 255     


Gly Trp Glu Thr Ile Thr Glu Ala Leu Lys Gln Gly Gly Ile Thr Leu 
            260                 265                 270         


Met Met Asp Arg Leu Ser Asn Pro Ala Lys Leu Arg Ala Tyr Ala Leu 
        275                 280                 285             


Ser Glu Gln Leu Lys Glu Ile Met Ala Pro Leu Phe Gln Lys His Met 
    290                 295                 300                 


Asp Asp Ile Ile Ser Gly Glu Phe Ser Ser Gly Met Met Ala Asp Trp 
305                 310                 315                 320 


Ala Asn Asp Asp Lys Lys Leu Leu Thr Trp Arg Glu Glu Thr Gly Lys 
                325                 330                 335     


Thr Ala Phe Glu Thr Ala Pro Gln Tyr Glu Gly Lys Ile Gly Glu Gln 
            340                 345                 350         


Glu Tyr Phe Asp Lys Gly Val Leu Met Ile Ala Met Val Lys Ala Gly 
        355                 360                 365             


Val Glu Leu Ala Phe Glu Thr Met Val Asp Ser Gly Ile Ile Glu Glu 
    370                 375                 380                 


Ser Ala Tyr Tyr Glu Ser Leu His Glu Leu Pro Leu Ile Ala Asn Thr 
385                 390                 395                 400 


Ile Ala Arg Lys Arg Leu Tyr Glu Met Asn Val Val Ile Ser Asp Thr 
                405                 410                 415     


Ala Glu Tyr Gly Asn Tyr Leu Phe Ser Tyr Ala Cys Val Pro Leu Leu 
            420                 425                 430         


Lys Pro Phe Met Ala Glu Leu Gln Pro Gly Asp Leu Gly Lys Ala Ile 
        435                 440                 445             


Pro Glu Gly Ala Val Asp Asn Gly Gln Leu Arg Asp Val Asn Glu Ala 
    450                 455                 460                 


Ile Arg Ser His Ala Ile Glu Gln Val Gly Lys Lys Leu Arg Gly Tyr 
465                 470                 475                 480 


Met Thr Asp Met Lys Arg Ile Ala Val Ala Gly 
                485                 490     


<210>  5
<211>  1851
<212>  DNA
<213>  Escherichia coli

<400>  5
atgcctaagt accgttccgc caccaccact catggtcgta atatggcggg tgctcgtgcg       60

ctgtggcgcg ccaccggaat gaccgacgcc gatttcggta agccgattat cgcggttgtg      120

aactcgttca cccaatttgt accgggtcac gtccatctgc gcgatctcgg taaactggtc      180

gccgaacaaa ttgaagcggc tggcggcgtt gccaaagagt tcaacaccat tgcggtggat      240

gatgggattg ccatgggcca cggggggatg ctttattcac tgccatctcg cgaactgatc      300

gctgattccg ttgagtatat ggtcaacgcc cactgcgccg acgccatggt ctgcatctct      360

aactgcgaca aaatcacccc ggggatgctg atggcttccc tgcgcctgaa tattccggtg      420

atctttgttt ccggcggccc gatggaggcc gggaaaacca aactttccga tcagatcatc      480

aagctcgatc tggttgatgc gatgatccag ggcgcagacc cgaaagtatc tgactcccag      540

agcgatcagg ttgaacgttc cgcgtgtccg acctgcggtt cctgctccgg gatgtttacc      600

gctaactcaa tgaactgcct gaccgaagcg ctgggcctgt cgcagccggg caacggctcg      660

ctgctggcaa cccacgccga ccgtaagcag ctgttcctta atgctggtaa acgcattgtt      720

gaattgacca aacgttatta cgagcaaaac gacgaaagtg cactgccgcg taatatcgcc      780

agtaaggcgg cgtttgaaaa cgccatgacg ctggatatcg cgatgggtgg atcgactaac      840

accgtacttc acctgctggc ggcggcgcag gaagcggaaa tcgacttcac catgagtgat      900

atcgataagc tttcccgcaa ggttccacag ctgtgtaaag ttgcgccgag cacccagaaa      960

taccatatgg aagatgttca ccgtgctggt ggtgttatcg gtattctcgg cgaactggat     1020

cgcgcggggt tactgaaccg tgatgtgaaa aacgtacttg gcctgacgtt gccgcaaacg     1080

ctggaacaat acgacgttat gctgacccag gatgacgcgg taaaaaatat gttccgcgca     1140

ggtcctgcag gcattcgtac cacacaggca ttctcgcaag attgccgttg ggatacgctg     1200

gacgacgatc gcgccaatgg ctgtatccgc tcgctggaac acgcctacag caaagacggc     1260

ggcctggcgg tgctctacgg taactttgcg gaaaacggct gcatcgtgaa aacggcaggc     1320

gtcgatgaca gcatcctcaa attcaccggc ccggcgaaag tgtacgaaag ccaggacgat     1380

gcggtagaag cgattctcgg cggtaaagtt gtcgccggag atgtggtagt aattcgctat     1440

gaaggcccga aaggcggtcc ggggatgcag gaaatgctct acccaaccag cttcctgaaa     1500

tcaatgggtc tcggcaaagc ctgtgcgctg atcaccgacg gtcgtttctc tggtggcacc     1560

tctggtcttt ccatcggcca cgtctcaccg gaagcggcaa gcggcggcag cattggcctg     1620

attgaagatg gtgacctgat cgctatcgac atcccgaacc gtggcattca gttacaggta     1680

agcgatgccg aactggcggc gcgtcgtgaa gcgcaggacg ctcgaggtga caaagcctgg     1740

acgccgaaaa atcgtgaacg tcaggtctcc tttgccctgc gtgcttatgc cagcctggca     1800

accagcgccg acaaaggcgc ggtgcgcgat aaatcgaaac tggggggtta a              1851


<210>  6
<211>  616
<212>  PRT
<213>  Escherichia coli

<400>  6

Met Pro Lys Tyr Arg Ser Ala Thr Thr Thr His Gly Arg Asn Met Ala 
1               5                   10                  15      


Gly Ala Arg Ala Leu Trp Arg Ala Thr Gly Met Thr Asp Ala Asp Phe 
            20                  25                  30          


Gly Lys Pro Ile Ile Ala Val Val Asn Ser Phe Thr Gln Phe Val Pro 
        35                  40                  45              


Gly His Val His Leu Arg Asp Leu Gly Lys Leu Val Ala Glu Gln Ile 
    50                  55                  60                  


Glu Ala Ala Gly Gly Val Ala Lys Glu Phe Asn Thr Ile Ala Val Asp 
65                  70                  75                  80  


Asp Gly Ile Ala Met Gly His Gly Gly Met Leu Tyr Ser Leu Pro Ser 
                85                  90                  95      


Arg Glu Leu Ile Ala Asp Ser Val Glu Tyr Met Val Asn Ala His Cys 
            100                 105                 110         


Ala Asp Ala Met Val Cys Ile Ser Asn Cys Asp Lys Ile Thr Pro Gly 
        115                 120                 125             


Met Leu Met Ala Ser Leu Arg Leu Asn Ile Pro Val Ile Phe Val Ser 
    130                 135                 140                 


Gly Gly Pro Met Glu Ala Gly Lys Thr Lys Leu Ser Asp Gln Ile Ile 
145                 150                 155                 160 


Lys Leu Asp Leu Val Asp Ala Met Ile Gln Gly Ala Asp Pro Lys Val 
                165                 170                 175     


Ser Asp Ser Gln Ser Asp Gln Val Glu Arg Ser Ala Cys Pro Thr Cys 
            180                 185                 190         


Gly Ser Cys Ser Gly Met Phe Thr Ala Asn Ser Met Asn Cys Leu Thr 
        195                 200                 205             


Glu Ala Leu Gly Leu Ser Gln Pro Gly Asn Gly Ser Leu Leu Ala Thr 
    210                 215                 220                 


His Ala Asp Arg Lys Gln Leu Phe Leu Asn Ala Gly Lys Arg Ile Val 
225                 230                 235                 240 


Glu Leu Thr Lys Arg Tyr Tyr Glu Gln Asn Asp Glu Ser Ala Leu Pro 
                245                 250                 255     


Arg Asn Ile Ala Ser Lys Ala Ala Phe Glu Asn Ala Met Thr Leu Asp 
            260                 265                 270         


Ile Ala Met Gly Gly Ser Thr Asn Thr Val Leu His Leu Leu Ala Ala 
        275                 280                 285             


Ala Gln Glu Ala Glu Ile Asp Phe Thr Met Ser Asp Ile Asp Lys Leu 
    290                 295                 300                 


Ser Arg Lys Val Pro Gln Leu Cys Lys Val Ala Pro Ser Thr Gln Lys 
305                 310                 315                 320 


Tyr His Met Glu Asp Val His Arg Ala Gly Gly Val Ile Gly Ile Leu 
                325                 330                 335     


Gly Glu Leu Asp Arg Ala Gly Leu Leu Asn Arg Asp Val Lys Asn Val 
            340                 345                 350         


Leu Gly Leu Thr Leu Pro Gln Thr Leu Glu Gln Tyr Asp Val Met Leu 
        355                 360                 365             


Thr Gln Asp Asp Ala Val Lys Asn Met Phe Arg Ala Gly Pro Ala Gly 
    370                 375                 380                 


Ile Arg Thr Thr Gln Ala Phe Ser Gln Asp Cys Arg Trp Asp Thr Leu 
385                 390                 395                 400 


Asp Asp Asp Arg Ala Asn Gly Cys Ile Arg Ser Leu Glu His Ala Tyr 
                405                 410                 415     


Ser Lys Asp Gly Gly Leu Ala Val Leu Tyr Gly Asn Phe Ala Glu Asn 
            420                 425                 430         


Gly Cys Ile Val Lys Thr Ala Gly Val Asp Asp Ser Ile Leu Lys Phe 
        435                 440                 445             


Thr Gly Pro Ala Lys Val Tyr Glu Ser Gln Asp Asp Ala Val Glu Ala 
    450                 455                 460                 


Ile Leu Gly Gly Lys Val Val Ala Gly Asp Val Val Val Ile Arg Tyr 
465                 470                 475                 480 


Glu Gly Pro Lys Gly Gly Pro Gly Met Gln Glu Met Leu Tyr Pro Thr 
                485                 490                 495     


Ser Phe Leu Lys Ser Met Gly Leu Gly Lys Ala Cys Ala Leu Ile Thr 
            500                 505                 510         


Asp Gly Arg Phe Ser Gly Gly Thr Ser Gly Leu Ser Ile Gly His Val 
        515                 520                 525             


Ser Pro Glu Ala Ala Ser Gly Gly Ser Ile Gly Leu Ile Glu Asp Gly 
    530                 535                 540                 


Asp Leu Ile Ala Ile Asp Ile Pro Asn Arg Gly Ile Gln Leu Gln Val 
545                 550                 555                 560 


Ser Asp Ala Glu Leu Ala Ala Arg Arg Glu Ala Gln Asp Ala Arg Gly 
                565                 570                 575     


Asp Lys Ala Trp Thr Pro Lys Asn Arg Glu Arg Gln Val Ser Phe Ala 
            580                 585                 590         


Leu Arg Ala Tyr Ala Ser Leu Ala Thr Ser Ala Asp Lys Gly Ala Val 
        595                 600                 605             


Arg Asp Lys Ser Lys Leu Gly Gly 
    610                 615     


<210>  7
<211>  1647
<212>  DNA
<213>  Lactococcus lactis

<400>  7
atgtatactg tgggggatta cctgctggat cgcctgcacg aactggggat tgaagaaatt       60

ttcggtgtgc caggcgatta taacctgcag ttcctggacc agattatctc gcacaaagat      120

atgaagtggg tcggtaacgc caacgaactg aacgcgagct atatggcaga tggttatgcc      180

cgtaccaaaa aagctgctgc gtttctgacg acctttggcg ttggcgaact gagcgccgtc      240

aacggactgg caggaagcta cgccgagaac ctgccagttg tcgaaattgt tgggtcgcct      300

acttctaagg ttcagaatga aggcaaattt gtgcaccata ctctggctga tggggatttt      360

aaacatttta tgaaaatgca tgaaccggtt actgcggccc gcacgctgct gacagcagag      420

aatgctacgg ttgagatcga ccgcgtcctg tctgcgctgc tgaaagagcg caagccggta      480

tatatcaatc tgcctgtcga tgttgccgca gcgaaagccg aaaagccgtc gctgccactg      540

aaaaaagaaa acagcacctc caatacatcg gaccaggaaa ttctgaataa aatccaggaa      600

tcactgaaga atgcgaagaa accgatcgtc atcaccggac atgagatcat ctcttttggc      660

ctggaaaaaa cggtcacgca gttcatttct aagaccaaac tgcctatcac caccctgaac      720

ttcggcaaat ctagcgtcga tgaagcgctg ccgagttttc tgggtatcta taatggtacc      780

ctgtccgaac cgaacctgaa agaattcgtc gaaagcgcgg actttatcct gatgctgggc      840

gtgaaactga cggatagctc cacaggcgca tttacccacc atctgaacga gaataaaatg      900

atttccctga atatcgacga aggcaaaatc tttaacgagc gcatccagaa cttcgatttt      960

gaatctctga ttagttcgct gctggatctg tccgaaattg agtataaagg taaatatatt     1020

gataaaaaac aggaggattt tgtgccgtct aatgcgctgc tgagtcagga tcgtctgtgg     1080

caagccgtag aaaacctgac acagtctaat gaaacgattg ttgcggaaca gggaacttca     1140

tttttcggcg cctcatccat ttttctgaaa tccaaaagcc atttcattgg ccaaccgctg     1200

tgggggagta ttggttatac ctttccggcg gcgctgggtt cacagattgc agataaggaa     1260

tcacgccatc tgctgtttat tggtgacggc agcctgcagc tgactgtcca ggaactgggg     1320

ctggcgatcc gtgaaaaaat caatccgatt tgctttatca tcaataacga cggctacacc     1380

gtcgaacgcg aaattcatgg accgaatcaa agttacaatg acatcccgat gtggaactat     1440

agcaaactgc cggaatcctt tggcgcgaca gaggatcgcg tggtgagtaa aattgtgcgt     1500

acggaaaacg aatttgtgtc ggttatgaaa gaagcgcagg ctgacccgaa tcgcatgtat     1560

tggattgaac tgatcctggc aaaagaaggc gcaccgaaag ttctgaaaaa gatggggaaa     1620

ctgtttgcgg agcaaaataa aagctaa                                         1647


<210>  8
<211>  548
<212>  PRT
<213>  Lactococcus lactis

<400>  8

Met Tyr Thr Val Gly Asp Tyr Leu Leu Asp Arg Leu His Glu Leu Gly 
1               5                   10                  15      


Ile Glu Glu Ile Phe Gly Val Pro Gly Asp Tyr Asn Leu Gln Phe Leu 
            20                  25                  30          


Asp Gln Ile Ile Ser His Lys Asp Met Lys Trp Val Gly Asn Ala Asn 
        35                  40                  45              


Glu Leu Asn Ala Ser Tyr Met Ala Asp Gly Tyr Ala Arg Thr Lys Lys 
    50                  55                  60                  


Ala Ala Ala Phe Leu Thr Thr Phe Gly Val Gly Glu Leu Ser Ala Val 
65                  70                  75                  80  


Asn Gly Leu Ala Gly Ser Tyr Ala Glu Asn Leu Pro Val Val Glu Ile 
                85                  90                  95      


Val Gly Ser Pro Thr Ser Lys Val Gln Asn Glu Gly Lys Phe Val His 
            100                 105                 110         


His Thr Leu Ala Asp Gly Asp Phe Lys His Phe Met Lys Met His Glu 
        115                 120                 125             


Pro Val Thr Ala Ala Arg Thr Leu Leu Thr Ala Glu Asn Ala Thr Val 
    130                 135                 140                 


Glu Ile Asp Arg Val Leu Ser Ala Leu Leu Lys Glu Arg Lys Pro Val 
145                 150                 155                 160 


Tyr Ile Asn Leu Pro Val Asp Val Ala Ala Ala Lys Ala Glu Lys Pro 
                165                 170                 175     


Ser Leu Pro Leu Lys Lys Glu Asn Ser Thr Ser Asn Thr Ser Asp Gln 
            180                 185                 190         


Glu Ile Leu Asn Lys Ile Gln Glu Ser Leu Lys Asn Ala Lys Lys Pro 
        195                 200                 205             


Ile Val Ile Thr Gly His Glu Ile Ile Ser Phe Gly Leu Glu Lys Thr 
    210                 215                 220                 


Val Thr Gln Phe Ile Ser Lys Thr Lys Leu Pro Ile Thr Thr Leu Asn 
225                 230                 235                 240 


Phe Gly Lys Ser Ser Val Asp Glu Ala Leu Pro Ser Phe Leu Gly Ile 
                245                 250                 255     


Tyr Asn Gly Thr Leu Ser Glu Pro Asn Leu Lys Glu Phe Val Glu Ser 
            260                 265                 270         


Ala Asp Phe Ile Leu Met Leu Gly Val Lys Leu Thr Asp Ser Ser Thr 
        275                 280                 285             


Gly Ala Phe Thr His His Leu Asn Glu Asn Lys Met Ile Ser Leu Asn 
    290                 295                 300                 


Ile Asp Glu Gly Lys Ile Phe Asn Glu Arg Ile Gln Asn Phe Asp Phe 
305                 310                 315                 320 


Glu Ser Leu Ile Ser Ser Leu Leu Asp Leu Ser Glu Ile Glu Tyr Lys 
                325                 330                 335     


Gly Lys Tyr Ile Asp Lys Lys Gln Glu Asp Phe Val Pro Ser Asn Ala 
            340                 345                 350         


Leu Leu Ser Gln Asp Arg Leu Trp Gln Ala Val Glu Asn Leu Thr Gln 
        355                 360                 365             


Ser Asn Glu Thr Ile Val Ala Glu Gln Gly Thr Ser Phe Phe Gly Ala 
    370                 375                 380                 


Ser Ser Ile Phe Leu Lys Ser Lys Ser His Phe Ile Gly Gln Pro Leu 
385                 390                 395                 400 


Trp Gly Ser Ile Gly Tyr Thr Phe Pro Ala Ala Leu Gly Ser Gln Ile 
                405                 410                 415     


Ala Asp Lys Glu Ser Arg His Leu Leu Phe Ile Gly Asp Gly Ser Leu 
            420                 425                 430         


Gln Leu Thr Val Gln Glu Leu Gly Leu Ala Ile Arg Glu Lys Ile Asn 
        435                 440                 445             


Pro Ile Cys Phe Ile Ile Asn Asn Asp Gly Tyr Thr Val Glu Arg Glu 
    450                 455                 460                 


Ile His Gly Pro Asn Gln Ser Tyr Asn Asp Ile Pro Met Trp Asn Tyr 
465                 470                 475                 480 


Ser Lys Leu Pro Glu Ser Phe Gly Ala Thr Glu Asp Arg Val Val Ser 
                485                 490                 495     


Lys Ile Val Arg Thr Glu Asn Glu Phe Val Ser Val Met Lys Glu Ala 
            500                 505                 510         


Gln Ala Asp Pro Asn Arg Met Tyr Trp Ile Glu Leu Ile Leu Ala Lys 
        515                 520                 525             


Glu Gly Ala Pro Lys Val Leu Lys Lys Met Gly Lys Leu Phe Ala Glu 
    530                 535                 540                 


Gln Asn Lys Ser 
545             


<210>  9
<211>  1047
<212>  DNA
<213>  Achromobacter xyloxidans

<400>  9
atgaaagctc tggtttatca cggtgaccac aagatctcgc ttgaagacaa gcccaagccc       60

acccttcaaa agcccacgga tgtagtagta cgggttttga agaccacgat ctgcggcacg      120

gatctcggca tctacaaagg caagaatcca gaggtcgccg acgggcgcat cctgggccat      180

gaaggggtag gcgtcatcga ggaagtgggc gagagtgtca cgcagttcaa gaaaggcgac      240

aaggtcctga tttcctgcgt cacttcttgc ggctcgtgcg actactgcaa gaagcagctt      300

tactcccatt gccgcgacgg cgggtggatc ctgggttaca tgatcgatgg cgtgcaggcc      360

gaatacgtcc gcatcccgca tgccgacaac agcctctaca agatccccca gacaattgac      420

gacgaaatcg ccgtcctgct gagcgacatc ctgcccaccg gccacgaaat cggcgtccag      480

tatgggaatg tccagccggg cgatgcggtg gctattgtcg gcgcgggccc cgtcggcatg      540

tccgtactgt tgaccgccca gttctactcc ccctcgacca tcatcgtgat cgacatggac      600

gagaatcgcc tccagctcgc caaggagctc ggggcaacgc acaccatcaa ctccggcacg      660

gagaacgttg tcgaagccgt gcataggatt gcggcagagg gagtcgatgt tgcgatcgag      720

gcggtgggca taccggcgac ttgggacatc tgccaggaga tcgtcaagcc cggcgcgcac      780

atcgccaacg tcggcgtgca tggcgtcaag gttgacttcg agattcagaa gctctggatc      840

aagaacctga cgatcaccac gggactggtg aacacgaaca cgacgcccat gctgatgaag      900

gtcgcctcga ccgacaagct tccgttgaag aagatgatta cccatcgctt cgagctggcc      960

gagatcgagc acgcctatca ggtattcctc aatggcgcca aggagaaggc gatgaagatc     1020

atcctctcga acgcaggcgc tgcctga                                         1047


<210>  10
<211>  348
<212>  PRT
<213>  Achromobacter xyloxidans

<400>  10

Met Lys Ala Leu Val Tyr His Gly Asp His Lys Ile Ser Leu Glu Asp 
1               5                   10                  15      


Lys Pro Lys Pro Thr Leu Gln Lys Pro Thr Asp Val Val Val Arg Val 
            20                  25                  30          


Leu Lys Thr Thr Ile Cys Gly Thr Asp Leu Gly Ile Tyr Lys Gly Lys 
        35                  40                  45              


Asn Pro Glu Val Ala Asp Gly Arg Ile Leu Gly His Glu Gly Val Gly 
    50                  55                  60                  


Val Ile Glu Glu Val Gly Glu Ser Val Thr Gln Phe Lys Lys Gly Asp 
65                  70                  75                  80  


Lys Val Leu Ile Ser Cys Val Thr Ser Cys Gly Ser Cys Asp Tyr Cys 
                85                  90                  95      


Lys Lys Gln Leu Tyr Ser His Cys Arg Asp Gly Gly Trp Ile Leu Gly 
            100                 105                 110         


Tyr Met Ile Asp Gly Val Gln Ala Glu Tyr Val Arg Ile Pro His Ala 
        115                 120                 125             


Asp Asn Ser Leu Tyr Lys Ile Pro Gln Thr Ile Asp Asp Glu Ile Ala 
    130                 135                 140                 


Val Leu Leu Ser Asp Ile Leu Pro Thr Gly His Glu Ile Gly Val Gln 
145                 150                 155                 160 


Tyr Gly Asn Val Gln Pro Gly Asp Ala Val Ala Ile Val Gly Ala Gly 
                165                 170                 175     


Pro Val Gly Met Ser Val Leu Leu Thr Ala Gln Phe Tyr Ser Pro Ser 
            180                 185                 190         


Thr Ile Ile Val Ile Asp Met Asp Glu Asn Arg Leu Gln Leu Ala Lys 
        195                 200                 205             


Glu Leu Gly Ala Thr His Thr Ile Asn Ser Gly Thr Glu Asn Val Val 
    210                 215                 220                 


Glu Ala Val His Arg Ile Ala Ala Glu Gly Val Asp Val Ala Ile Glu 
225                 230                 235                 240 


Ala Val Gly Ile Pro Ala Thr Trp Asp Ile Cys Gln Glu Ile Val Lys 
                245                 250                 255     


Pro Gly Ala His Ile Ala Asn Val Gly Val His Gly Val Lys Val Asp 
            260                 265                 270         


Phe Glu Ile Gln Lys Leu Trp Ile Lys Asn Leu Thr Ile Thr Thr Gly 
        275                 280                 285             


Leu Val Asn Thr Asn Thr Thr Pro Met Leu Met Lys Val Ala Ser Thr 
    290                 295                 300                 


Asp Lys Leu Pro Leu Lys Lys Met Ile Thr His Arg Phe Glu Leu Ala 
305                 310                 315                 320 


Glu Ile Glu His Ala Tyr Gln Val Phe Leu Asn Gly Ala Lys Glu Lys 
                325                 330                 335     


Ala Met Lys Ile Ile Leu Ser Asn Ala Gly Ala Ala 
            340                 345             


<210>  11
<211>  1713
<212>  DNA
<213>  Bacillus subtilis

<400>  11
ttgacaaaag caacaaaaga acaaaaatcc cttgtgaaaa acagaggggc ggagcttgtt       60

gttgattgct tagtggagca aggtgtcaca catgtatttg gcattccagg tgcaaaaatt      120

gatgcggtat ttgacgcttt acaagataaa ggacctgaaa ttatcgttgc ccggcacgaa      180

caaaacgcag cattcatggc ccaagcagtc ggccgtttaa ctggaaaacc gggagtcgtg      240

ttagtcacat caggaccggg tgcctctaac ttggcaacag gcctgctgac agcgaacact      300

gaaggagacc ctgtcgttgc gcttgctgga aacgtgatcc gtgcagatcg tttaaaacgg      360

acacatcaat ctttggataa tgcggcgcta ttccagccga ttacaaaata cagtgtagaa      420

gttcaagatg taaaaaatat accggaagct gttacaaatg catttaggat agcgtcagca      480

gggcaggctg gggccgcttt tgtgagcttt ccgcaagatg ttgtgaatga agtcacaaat      540

acgaaaaacg tgcgtgctgt tgcagcgcca aaactcggtc ctgcagcaga tgatgcaatc      600

agtgcggcca tagcaaaaat ccaaacagca aaacttcctg tcgttttggt cggcatgaaa      660

ggcggaagac cggaagcaat taaagcggtt cgcaagcttt tgaaaaaggt tcagcttcca      720

tttgttgaaa catatcaagc tgccggtacc ctttctagag atttagagga tcaatatttt      780

ggccgtatcg gtttgttccg caaccagcct ggcgatttac tgctagagca ggcagatgtt      840

gttctgacga tcggctatga cccgattgaa tatgatccga aattctggaa tatcaatgga      900

gaccggacaa ttatccattt agacgagatt atcgctgaca ttgatcatgc ttaccagcct      960

gatcttgaat tgatcggtga cattccgtcc acgatcaatc atatcgaaca cgatgctgtg     1020

aaagtggaat ttgcagagcg tgagcagaaa atcctttctg atttaaaaca atatatgcat     1080

gaaggtgagc aggtgcctgc agattggaaa tcagacagag cgcaccctct tgaaatcgtt     1140

aaagagttgc gtaatgcagt cgatgatcat gttacagtaa cttgcgatat cggttcgcac     1200

gccatttgga tgtcacgtta tttccgcagc tacgagccgt taacattaat gatcagtaac     1260

ggtatgcaaa cactcggcgt tgcgcttcct tgggcaatcg gcgcttcatt ggtgaaaccg     1320

ggagaaaaag tggtttctgt ctctggtgac ggcggtttct tattctcagc aatggaatta     1380

gagacagcag ttcgactaaa agcaccaatt gtacacattg tatggaacga cagcacatat     1440

gacatggttg cattccagca attgaaaaaa tataaccgta catctgcggt cgatttcgga     1500

aatatcgata tcgtgaaata tgcggaaagc ttcggagcaa ctggcttgcg cgtagaatca     1560

ccagaccagc tggcagatgt tctgcgtcaa ggcatgaacg ctgaaggtcc tgtcatcatc     1620

gatgtcccgg ttgactacag tgataacatt aatttagcaa gtgacaagct tccgaaagaa     1680

ttcggggaac tcatgaaaac gaaagctctc tag                                  1713


<210>  12
<211>  570
<212>  PRT
<213>  Bacillus subtilis

<400>  12

Met Thr Lys Ala Thr Lys Glu Gln Lys Ser Leu Val Lys Asn Arg Gly 
1               5                   10                  15      


Ala Glu Leu Val Val Asp Cys Leu Val Glu Gln Gly Val Thr His Val 
            20                  25                  30          


Phe Gly Ile Pro Gly Ala Lys Ile Asp Ala Val Phe Asp Ala Leu Gln 
        35                  40                  45              


Asp Lys Gly Pro Glu Ile Ile Val Ala Arg His Glu Gln Asn Ala Ala 
    50                  55                  60                  


Phe Met Ala Gln Ala Val Gly Arg Leu Thr Gly Lys Pro Gly Val Val 
65                  70                  75                  80  


Leu Val Thr Ser Gly Pro Gly Ala Ser Asn Leu Ala Thr Gly Leu Leu 
                85                  90                  95      


Thr Ala Asn Thr Glu Gly Asp Pro Val Val Ala Leu Ala Gly Asn Val 
            100                 105                 110         


Ile Arg Ala Asp Arg Leu Lys Arg Thr His Gln Ser Leu Asp Asn Ala 
        115                 120                 125             


Ala Leu Phe Gln Pro Ile Thr Lys Tyr Ser Val Glu Val Gln Asp Val 
    130                 135                 140                 


Lys Asn Ile Pro Glu Ala Val Thr Asn Ala Phe Arg Ile Ala Ser Ala 
145                 150                 155                 160 


Gly Gln Ala Gly Ala Ala Phe Val Ser Phe Pro Gln Asp Val Val Asn 
                165                 170                 175     


Glu Val Thr Asn Thr Lys Asn Val Arg Ala Val Ala Ala Pro Lys Leu 
            180                 185                 190         


Gly Pro Ala Ala Asp Asp Ala Ile Ser Ala Ala Ile Ala Lys Ile Gln 
        195                 200                 205             


Thr Ala Lys Leu Pro Val Val Leu Val Gly Met Lys Gly Gly Arg Pro 
    210                 215                 220                 


Glu Ala Ile Lys Ala Val Arg Lys Leu Leu Lys Lys Val Gln Leu Pro 
225                 230                 235                 240 


Phe Val Glu Thr Tyr Gln Ala Ala Gly Thr Leu Ser Arg Asp Leu Glu 
                245                 250                 255     


Asp Gln Tyr Phe Gly Arg Ile Gly Leu Phe Arg Asn Gln Pro Gly Asp 
            260                 265                 270         


Leu Leu Leu Glu Gln Ala Asp Val Val Leu Thr Ile Gly Tyr Asp Pro 
        275                 280                 285             


Ile Glu Tyr Asp Pro Lys Phe Trp Asn Ile Asn Gly Asp Arg Thr Ile 
    290                 295                 300                 


Ile His Leu Asp Glu Ile Ile Ala Asp Ile Asp His Ala Tyr Gln Pro 
305                 310                 315                 320 


Asp Leu Glu Leu Ile Gly Asp Ile Pro Ser Thr Ile Asn His Ile Glu 
                325                 330                 335     


His Asp Ala Val Lys Val Glu Phe Ala Glu Arg Glu Gln Lys Ile Leu 
            340                 345                 350         


Ser Asp Leu Lys Gln Tyr Met His Glu Gly Glu Gln Val Pro Ala Asp 
        355                 360                 365             


Trp Lys Ser Asp Arg Ala His Pro Leu Glu Ile Val Lys Glu Leu Arg 
    370                 375                 380                 


Asn Ala Val Asp Asp His Val Thr Val Thr Cys Asp Ile Gly Ser His 
385                 390                 395                 400 


Ala Ile Trp Met Ser Arg Tyr Phe Arg Ser Tyr Glu Pro Leu Thr Leu 
                405                 410                 415     


Met Ile Ser Asn Gly Met Gln Thr Leu Gly Val Ala Leu Pro Trp Ala 
            420                 425                 430         


Ile Gly Ala Ser Leu Val Lys Pro Gly Glu Lys Val Val Ser Val Ser 
        435                 440                 445             


Gly Asp Gly Gly Phe Leu Phe Ser Ala Met Glu Leu Glu Thr Ala Val 
    450                 455                 460                 


Arg Leu Lys Ala Pro Ile Val His Ile Val Trp Asn Asp Ser Thr Tyr 
465                 470                 475                 480 


Asp Met Val Ala Phe Gln Gln Leu Lys Lys Tyr Asn Arg Thr Ser Ala 
                485                 490                 495     


Val Asp Phe Gly Asn Ile Asp Ile Val Lys Tyr Ala Glu Ser Phe Gly 
            500                 505                 510         


Ala Thr Gly Leu Arg Val Glu Ser Pro Asp Gln Leu Ala Asp Val Leu 
        515                 520                 525             


Arg Gln Gly Met Asn Ala Glu Gly Pro Val Ile Ile Asp Val Pro Val 
    530                 535                 540                 


Asp Tyr Ser Asp Asn Ile Asn Leu Ala Ser Asp Lys Leu Pro Lys Glu 
545                 550                 555                 560 


Phe Gly Glu Leu Met Lys Thr Lys Ala Leu 
                565                 570 


<210>  13
<211>  1188
<212>  DNA
<213>  Saccharomyces cerevisiae

<400>  13
atgttgagaa ctcaagccgc cagattgatc tgcaactccc gtgtcatcac tgctaagaga       60

acctttgctt tggccacccg tgctgctgct tacagcagac cagctgcccg tttcgttaag      120

ccaatgatca ctacccgtgg tttgaagcaa atcaacttcg gtggtactgt tgaaaccgtc      180

tacgaaagag ctgactggcc aagagaaaag ttgttggact acttcaagaa cgacactttt      240

gctttgatcg gttacggttc ccaaggttac ggtcaaggtt tgaacttgag agacaacggt      300

ttgaacgtta tcattggtgt ccgtaaagat ggtgcttctt ggaaggctgc catcgaagac      360

ggttgggttc caggcaagaa cttgttcact gttgaagatg ctatcaagag aggtagttac      420

gttatgaact tgttgtccga tgccgctcaa tcagaaacct ggcctgctat caagccattg      480

ttgaccaagg gtaagacttt gtacttctcc cacggtttct ccccagtctt caaggacttg      540

actcacgttg aaccaccaaa ggacttagat gttatcttgg ttgctccaaa gggttccggt      600

agaactgtca gatctttgtt caaggaaggt cgtggtatta actcttctta cgccgtctgg      660

aacgatgtca ccggtaaggc tcacgaaaag gcccaagctt tggccgttgc cattggttcc      720

ggttacgttt accaaaccac tttcgaaaga gaagtcaact ctgacttgta cggtgaaaga      780

ggttgtttaa tgggtggtat ccacggtatg ttcttggctc aatacgacgt cttgagagaa      840

aacggtcact ccccatctga agctttcaac gaaaccgtcg aagaagctac ccaatctcta      900

tacccattga tcggtaagta cggtatggat tacatgtacg atgcttgttc caccaccgcc      960

agaagaggtg ctttggactg gtacccaatc ttcaagaatg ctttgaagcc tgttttccaa     1020

gacttgtacg aatctaccaa gaacggtacc gaaaccaaga gatctttgga attcaactct     1080

caacctgact acagagaaaa gctagaaaag gaattagaca ccatcagaaa catggaaatc     1140

tggaaggttg gtaaggaagt cagaaagttg agaccagaaa accaataa                  1188


<210>  14
<211>  395
<212>  PRT
<213>  Saccharomyces cerevisiae

<400>  14

Met Leu Arg Thr Gln Ala Ala Arg Leu Ile Cys Asn Ser Arg Val Ile 
1               5                   10                  15      


Thr Ala Lys Arg Thr Phe Ala Leu Ala Thr Arg Ala Ala Ala Tyr Ser 
            20                  25                  30          


Arg Pro Ala Ala Arg Phe Val Lys Pro Met Ile Thr Thr Arg Gly Leu 
        35                  40                  45              


Lys Gln Ile Asn Phe Gly Gly Thr Val Glu Thr Val Tyr Glu Arg Ala 
    50                  55                  60                  


Asp Trp Pro Arg Glu Lys Leu Leu Asp Tyr Phe Lys Asn Asp Thr Phe 
65                  70                  75                  80  


Ala Leu Ile Gly Tyr Gly Ser Gln Gly Tyr Gly Gln Gly Leu Asn Leu 
                85                  90                  95      


Arg Asp Asn Gly Leu Asn Val Ile Ile Gly Val Arg Lys Asp Gly Ala 
            100                 105                 110         


Ser Trp Lys Ala Ala Ile Glu Asp Gly Trp Val Pro Gly Lys Asn Leu 
        115                 120                 125             


Phe Thr Val Glu Asp Ala Ile Lys Arg Gly Ser Tyr Val Met Asn Leu 
    130                 135                 140                 


Leu Ser Asp Ala Ala Gln Ser Glu Thr Trp Pro Ala Ile Lys Pro Leu 
145                 150                 155                 160 


Leu Thr Lys Gly Lys Thr Leu Tyr Phe Ser His Gly Phe Ser Pro Val 
                165                 170                 175     


Phe Lys Asp Leu Thr His Val Glu Pro Pro Lys Asp Leu Asp Val Ile 
            180                 185                 190         


Leu Val Ala Pro Lys Gly Ser Gly Arg Thr Val Arg Ser Leu Phe Lys 
        195                 200                 205             


Glu Gly Arg Gly Ile Asn Ser Ser Tyr Ala Val Trp Asn Asp Val Thr 
    210                 215                 220                 


Gly Lys Ala His Glu Lys Ala Gln Ala Leu Ala Val Ala Ile Gly Ser 
225                 230                 235                 240 


Gly Tyr Val Tyr Gln Thr Thr Phe Glu Arg Glu Val Asn Ser Asp Leu 
                245                 250                 255     


Tyr Gly Glu Arg Gly Cys Leu Met Gly Gly Ile His Gly Met Phe Leu 
            260                 265                 270         


Ala Gln Tyr Asp Val Leu Arg Glu Asn Gly His Ser Pro Ser Glu Ala 
        275                 280                 285             


Phe Asn Glu Thr Val Glu Glu Ala Thr Gln Ser Leu Tyr Pro Leu Ile 
    290                 295                 300                 


Gly Lys Tyr Gly Met Asp Tyr Met Tyr Asp Ala Cys Ser Thr Thr Ala 
305                 310                 315                 320 


Arg Arg Gly Ala Leu Asp Trp Tyr Pro Ile Phe Lys Asn Ala Leu Lys 
                325                 330                 335     


Pro Val Phe Gln Asp Leu Tyr Glu Ser Thr Lys Asn Gly Thr Glu Thr 
            340                 345                 350         


Lys Arg Ser Leu Glu Phe Asn Ser Gln Pro Asp Tyr Arg Glu Lys Leu 
        355                 360                 365             


Glu Lys Glu Leu Asp Thr Ile Arg Asn Met Glu Ile Trp Lys Val Gly 
    370                 375                 380                 


Lys Glu Val Arg Lys Leu Arg Pro Glu Asn Gln 
385                 390                 395 


<210>  15
<211>  1014
<212>  DNA
<213>  artificial sequence

<220>
<223>  Mutant of Pseudomonas fluorescens ilvC coding region

<400>  15
atgaaggtgt tttacgataa agactgcgat ctgagcatca tccagggaaa gaaggttgct       60

attataggat atggttccca aggacacgca caagccttga acttgaaaga ttctggggtc      120

gacgtgacag taggtctgta taaaggtgct gctgatgcag caaaggctga agcacatggc      180

tttaaagtca cagatgttgc agcggctgtt gctggcgctg atttagtcat gattttaatt      240

ccagatgaat ttcaatcgca attgtacaaa aatgaaatag aaccaaacat taagaagggc      300

gctaccttgg ccttcagtca tggatttgcc attcattaca atcaagtagt ccccagggca      360

gatttggacg ttattatgat tgcacctaag gctccggggc atactgttag gagcgaattt      420

gttaagggtg gtggtattcc agatttgatc gctatatacc aagacgttag cggaaacgct      480

aagaatgtag ctttaagcta cgcagcagga gttggtggcg ggagaacggg tataatagaa      540

accactttta aagacgagac tgagacagat ttatttggag aacaagcggt tctgtgcgga      600

ggaactgttg aattggttaa agcaggcttt gagacgcttg tcgaagcagg gtacgctccc      660

gaaatggcat acttcgaatg tctacatgaa ttgaagttga tagtagactt aatgtatgaa      720

ggtggtatag ctaatatgaa ctattccatt tcaaataatg cagaatatgg tgagtatgtc      780

accggacctg aagtcattaa cgcagaatca agacaagcca tgagaaatgc cttgaaacgt      840

atccaggacg gtgaatacgc taagatgttc ataagtgaag gcgctacggg ttacccgagt      900

atgactgcta aaagaagaaa caatgcagca catggtatcg aaattattgg tgaacagtta      960

aggtctatga tgccctggat cggtgctaat aagatcgtag acaaggcgaa aaat           1014


<210>  16
<211>  338
<212>  PRT
<213>  artificial sequence

<220>
<223>  mutant of Pseudomonas fluorescens protein

<400>  16

Met Lys Val Phe Tyr Asp Lys Asp Cys Asp Leu Ser Ile Ile Gln Gly 
1               5                   10                  15      


Lys Lys Val Ala Ile Ile Gly Tyr Gly Ser Gln Gly His Ala Gln Ala 
            20                  25                  30          


Leu Asn Leu Lys Asp Ser Gly Val Asp Val Thr Val Gly Leu Tyr Lys 
        35                  40                  45              


Gly Ala Ala Asp Ala Ala Lys Ala Glu Ala His Gly Phe Lys Val Thr 
    50                  55                  60                  


Asp Val Ala Ala Ala Val Ala Gly Ala Asp Leu Val Met Ile Leu Ile 
65                  70                  75                  80  


Pro Asp Glu Phe Gln Ser Gln Leu Tyr Lys Asn Glu Ile Glu Pro Asn 
                85                  90                  95      


Ile Lys Lys Gly Ala Thr Leu Ala Phe Ser His Gly Phe Ala Ile His 
            100                 105                 110         


Tyr Asn Gln Val Val Pro Arg Ala Asp Leu Asp Val Ile Met Ile Ala 
        115                 120                 125             


Pro Lys Ala Pro Gly His Thr Val Arg Ser Glu Phe Val Lys Gly Gly 
    130                 135                 140                 


Gly Ile Pro Asp Leu Ile Ala Ile Tyr Gln Asp Val Ser Gly Asn Ala 
145                 150                 155                 160 


Lys Asn Val Ala Leu Ser Tyr Ala Ala Ala Val Gly Gly Gly Arg Thr 
                165                 170                 175     


Gly Ile Ile Glu Thr Thr Phe Lys Asp Glu Thr Glu Thr Asp Leu Phe 
            180                 185                 190         


Gly Glu Gln Ala Val Leu Cys Gly Gly Thr Val Glu Leu Val Lys Ala 
        195                 200                 205             


Gly Phe Glu Thr Leu Val Glu Ala Gly Tyr Ala Pro Glu Met Ala Tyr 
    210                 215                 220                 


Phe Glu Cys Leu His Glu Leu Lys Leu Ile Val Asp Leu Met Tyr Glu 
225                 230                 235                 240 


Gly Gly Ile Ala Asn Met Asn Tyr Ser Ile Ser Asn Asn Ala Glu Tyr 
                245                 250                 255     


Gly Glu Tyr Val Thr Gly Pro Glu Val Ile Asn Ala Glu Ser Arg Gln 
            260                 265                 270         


Ala Met Arg Asn Ala Leu Lys Arg Ile Gln Asp Gly Glu Tyr Ala Lys 
        275                 280                 285             


Met Phe Ile Ser Glu Gly Ala Thr Gly Tyr Pro Ser Met Thr Ala Lys 
    290                 295                 300                 


Arg Arg Asn Asn Ala Ala His Gly Ile Glu Ile Ile Gly Glu Gln Leu 
305                 310                 315                 320 


Arg Ser Met Met Pro Trp Ile Gly Ala Asn Lys Ile Val Asp Lys Ala 
                325                 330                 335     


Lys Asn 
        


<210>  17
<211>  1713
<212>  DNA
<213>  Streptococcus mutans

<400>  17
atgactgaca aaaaaactct taaagactta agaaatcgta gttctgttta cgattcaatg       60

gttaaatcac ctaatcgtgc tatgttgcgt gcaactggta tgcaagatga agactttgaa      120

aaacctatcg tcggtgtcat ttcaacttgg gctgaaaaca caccttgtaa tatccactta      180

catgactttg gtaaactagc caaagtcggt gttaaggaag ctggtgcttg gccagttcag      240

ttcggaacaa tcacggtttc tgatggaatc gccatgggaa cccaaggaat gcgtttctcc      300

ttgacatctc gtgatattat tgcagattct attgaagcag ccatgggagg tcataatgcg      360

gatgcttttg tagccattgg cggttgtgat aaaaacatgc ccggttctgt tatcgctatg      420

gctaacatgg atatcccagc catttttgct tacggcggaa caattgcacc tggtaattta      480

gacggcaaag atatcgattt agtctctgtc tttgaaggtg tcggccattg gaaccacggc      540

gatatgacca aagaagaagt taaagctttg gaatgtaatg cttgtcccgg tcctggaggc      600

tgcggtggta tgtatactgc taacacaatg gcgacagcta ttgaagtttt gggacttagc      660

cttccgggtt catcttctca cccggctgaa tccgcagaaa agaaagcaga tattgaagaa      720

gctggtcgcg ctgttgtcaa aatgctcgaa atgggcttaa aaccttctga cattttaacg      780

cgtgaagctt ttgaagatgc tattactgta actatggctc tgggaggttc aaccaactca      840

acccttcacc tcttagctat tgcccatgct gctaatgtgg aattgacact tgatgatttc      900

aatactttcc aagaaaaagt tcctcatttg gctgatttga aaccttctgg tcaatatgta      960

ttccaagacc tttacaaggt cggaggggta ccagcagtta tgaaatatct ccttaaaaat     1020

ggcttccttc atggtgaccg tatcacttgt actggcaaaa cagtcgctga aaatttgaag     1080

gcttttgatg atttaacacc tggtcaaaag gttattatgc cgcttgaaaa tcctaaacgt     1140

gaagatggtc cgctcattat tctccatggt aacttggctc cagacggtgc cgttgccaaa     1200

gtttctggtg taaaagtgcg tcgtcatgtc ggtcctgcta aggtctttaa ttctgaagaa     1260

gaagccattg aagctgtctt gaatgatgat attgttgatg gtgatgttgt tgtcgtacgt     1320

tttgtaggac caaagggcgg tcctggtatg cctgaaatgc tttccctttc atcaatgatt     1380

gttggtaaag ggcaaggtga aaaagttgcc cttctgacag atggccgctt ctcaggtggt     1440

acttatggtc ttgtcgtggg tcatatcgct cctgaagcac aagatggcgg tccaatcgcc     1500

tacctgcaaa caggagacat agtcactatt gaccaagaca ctaaggaatt acactttgat     1560

atctccgatg aagagttaaa acatcgtcaa gagaccattg aattgccacc gctctattca     1620

cgcggtatcc ttggtaaata tgctcacatc gtttcgtctg cttctagggg agccgtaaca     1680

gacttttgga agcctgaaga aactggcaaa aaa                                  1713


<210>  18
<211>  571
<212>  PRT
<213>  Streptococcus mutans

<400>  18

Met Thr Asp Lys Lys Thr Leu Lys Asp Leu Arg Asn Arg Ser Ser Val 
1               5                   10                  15      


Tyr Asp Ser Met Val Lys Ser Pro Asn Arg Ala Met Leu Arg Ala Thr 
            20                  25                  30          


Gly Met Gln Asp Glu Asp Phe Glu Lys Pro Ile Val Gly Val Ile Ser 
        35                  40                  45              


Thr Trp Ala Glu Asn Thr Pro Cys Asn Ile His Leu His Asp Phe Gly 
    50                  55                  60                  


Lys Leu Ala Lys Val Gly Val Lys Glu Ala Gly Ala Trp Pro Val Gln 
65                  70                  75                  80  


Phe Gly Thr Ile Thr Val Ser Asp Gly Ile Ala Met Gly Thr Gln Gly 
                85                  90                  95      


Met Arg Phe Ser Leu Thr Ser Arg Asp Ile Ile Ala Asp Ser Ile Glu 
            100                 105                 110         


Ala Ala Met Gly Gly His Asn Ala Asp Ala Phe Val Ala Ile Gly Gly 
        115                 120                 125             


Cys Asp Lys Asn Met Pro Gly Ser Val Ile Ala Met Ala Asn Met Asp 
    130                 135                 140                 


Ile Pro Ala Ile Phe Ala Tyr Gly Gly Thr Ile Ala Pro Gly Asn Leu 
145                 150                 155                 160 


Asp Gly Lys Asp Ile Asp Leu Val Ser Val Phe Glu Gly Val Gly His 
                165                 170                 175     


Trp Asn His Gly Asp Met Thr Lys Glu Glu Val Lys Ala Leu Glu Cys 
            180                 185                 190         


Asn Ala Cys Pro Gly Pro Gly Gly Cys Gly Gly Met Tyr Thr Ala Asn 
        195                 200                 205             


Thr Met Ala Thr Ala Ile Glu Val Leu Gly Leu Ser Leu Pro Gly Ser 
    210                 215                 220                 


Ser Ser His Pro Ala Glu Ser Ala Glu Lys Lys Ala Asp Ile Glu Glu 
225                 230                 235                 240 


Ala Gly Arg Ala Val Val Lys Met Leu Glu Met Gly Leu Lys Pro Ser 
                245                 250                 255     


Asp Ile Leu Thr Arg Glu Ala Phe Glu Asp Ala Ile Thr Val Thr Met 
            260                 265                 270         


Ala Leu Gly Gly Ser Thr Asn Ser Thr Leu His Leu Leu Ala Ile Ala 
        275                 280                 285             


His Ala Ala Asn Val Glu Leu Thr Leu Asp Asp Phe Asn Thr Phe Gln 
    290                 295                 300                 


Glu Lys Val Pro His Leu Ala Asp Leu Lys Pro Ser Gly Gln Tyr Val 
305                 310                 315                 320 


Phe Gln Asp Leu Tyr Lys Val Gly Gly Val Pro Ala Val Met Lys Tyr 
                325                 330                 335     


Leu Leu Lys Asn Gly Phe Leu His Gly Asp Arg Ile Thr Cys Thr Gly 
            340                 345                 350         


Lys Thr Val Ala Glu Asn Leu Lys Ala Phe Asp Asp Leu Thr Pro Gly 
        355                 360                 365             


Gln Lys Val Ile Met Pro Leu Glu Asn Pro Lys Arg Glu Asp Gly Pro 
    370                 375                 380                 


Leu Ile Ile Leu His Gly Asn Leu Ala Pro Asp Gly Ala Val Ala Lys 
385                 390                 395                 400 


Val Ser Gly Val Lys Val Arg Arg His Val Gly Pro Ala Lys Val Phe 
                405                 410                 415     


Asn Ser Glu Glu Glu Ala Ile Glu Ala Val Leu Asn Asp Asp Ile Val 
            420                 425                 430         


Asp Gly Asp Val Val Val Val Arg Phe Val Gly Pro Lys Gly Gly Pro 
        435                 440                 445             


Gly Met Pro Glu Met Leu Ser Leu Ser Ser Met Ile Val Gly Lys Gly 
    450                 455                 460                 


Gln Gly Glu Lys Val Ala Leu Leu Thr Asp Gly Arg Phe Ser Gly Gly 
465                 470                 475                 480 


Thr Tyr Gly Leu Val Val Gly His Ile Ala Pro Glu Ala Gln Asp Gly 
                485                 490                 495     


Gly Pro Ile Ala Tyr Leu Gln Thr Gly Asp Ile Val Thr Ile Asp Gln 
            500                 505                 510         


Asp Thr Lys Glu Leu His Phe Asp Ile Ser Asp Glu Glu Leu Lys His 
        515                 520                 525             


Arg Gln Glu Thr Ile Glu Leu Pro Pro Leu Tyr Ser Arg Gly Ile Leu 
    530                 535                 540                 


Gly Lys Tyr Ala His Ile Val Ser Ser Ala Ser Arg Gly Ala Val Thr 
545                 550                 555                 560 


Asp Phe Trp Lys Pro Glu Glu Thr Gly Lys Lys 
                565                 570     


<210>  19
<211>  1644
<212>  DNA
<213>  artificial sequence

<220>
<223>  Bacillus subtilis kivD coding region codon optimized for 
       expression is S. cerevisiae

<400>  19
atgtatacag taggtgacta tctgttggac agattacacg aattaggtat agaagaaata       60

ttcggagtac caggtgacta caatttgcaa tttctagatc aaattatttc acacaaagat      120

atgaaatggg tgggaaatgc taatgagtta aatgcctcct atatggccga cgggtacgca      180

agaacgaaaa aggctgcggc attcttgact acatttggtg ttggcgaatt atccgcagtt      240

aatggcttag cgggctccta tgctgagaac ctgcctgttg ttgagatcgt gggatctcct      300

acctcgaaag tgcagaacga aggtaagttt gttcaccata cgttggctga tggtgatttc      360

aagcacttta tgaagatgca cgaaccggtt actgctgcca ggactttatt gacagccgag      420

aatgcaactg ttgaaattga tagagtgttg tctgccttac taaaggaaag aaagccggtt      480

tacatcaatt tacctgtaga tgtagctgcc gctaaggctg aaaaaccatc cttgcctctt      540

aagaaggaaa attccacgtc gaatacatct gatcaagaga ttctgaacaa aatacaggaa      600

agtctgaaga atgccaagaa accaattgta atcacaggcc atgaaattat atcgttcggc      660

ctagagaaga ctgttactca gtttatttca aagactaagt tacctattac tactttgaac      720

tttggtaaat catctgttga tgaagcattg ccctcatttt tggggattta caacggtact      780

ctgtcagagc caaacttgaa ggaatttgtg gaatctgctg attttattct tatgttgggt      840

gtaaagctta ccgattctag tacgggtgca tttactcacc atcttaatga aaataaaatg      900

atttccttga atatcgatga aggtaaaatt ttcaacgaaa gaatccaaaa tttcgacttc      960

gaatccctga tatcatctct tcttgacttg tccgaaattg aatataaagg caagtacata     1020

gataaaaagc aagaagattt tgtaccttct aacgcgctgt tgtcacaaga tagactgtgg     1080

caagctgtcg aaaatttgac ccaaagtaat gagacgatcg tggctgaaca aggcacttct     1140

ttcttcggtg cctcatctat atttctgaaa tcgaaatcac attttattgg tcaacccttg     1200

tggggatcta taggatacac tttccccgca gctctaggca gccaaattgc agataaagaa     1260

tctagacatt tattgtttat cggagatgga tcattgcaac tgactgtcca agaattagga     1320

ctagccatta gagagaagat aaacccaatc tgctttatca ttaataacga tggttacacg     1380

gttgagaggg aaattcatgg tccgaaccag agttataatg acattcctat gtggaattac     1440

tcaaaactgc cagaaagttt cggggcaacg gaagacagag ttgtgtccaa aattgtgaga     1500

acagaaaatg aattcgtatc cgtgatgaaa gaagctcaag cagatccaaa taggatgtat     1560

tggatagaac ttattctagc aaaggagggt gcacctaaag ttttgaaaaa gatgggtaag     1620

ttatttgcag aacaaaacaa gagc                                            1644


<210>  20
<211>  548
<212>  PRT
<213>  Bacillus subtilis

<400>  20

Met Tyr Thr Val Gly Asp Tyr Leu Leu Asp Arg Leu His Glu Leu Gly 
1               5                   10                  15      


Ile Glu Glu Ile Phe Gly Val Pro Gly Asp Tyr Asn Leu Gln Phe Leu 
            20                  25                  30          


Asp Gln Ile Ile Ser His Lys Asp Met Lys Trp Val Gly Asn Ala Asn 
        35                  40                  45              


Glu Leu Asn Ala Ser Tyr Met Ala Asp Gly Tyr Ala Arg Thr Lys Lys 
    50                  55                  60                  


Ala Ala Ala Phe Leu Thr Thr Phe Gly Val Gly Glu Leu Ser Ala Val 
65                  70                  75                  80  


Asn Gly Leu Ala Gly Ser Tyr Ala Glu Asn Leu Pro Val Val Glu Ile 
                85                  90                  95      


Val Gly Ser Pro Thr Ser Lys Val Gln Asn Glu Gly Lys Phe Val His 
            100                 105                 110         


His Thr Leu Ala Asp Gly Asp Phe Lys His Phe Met Lys Met His Glu 
        115                 120                 125             


Pro Val Thr Ala Ala Arg Thr Leu Leu Thr Ala Glu Asn Ala Thr Val 
    130                 135                 140                 


Glu Ile Asp Arg Val Leu Ser Ala Leu Leu Lys Glu Arg Lys Pro Val 
145                 150                 155                 160 


Tyr Ile Asn Leu Pro Val Asp Val Ala Ala Ala Lys Ala Glu Lys Pro 
                165                 170                 175     


Ser Leu Pro Leu Lys Lys Glu Asn Ser Thr Ser Asn Thr Ser Asp Gln 
            180                 185                 190         


Glu Ile Leu Asn Lys Ile Gln Glu Ser Leu Lys Asn Ala Lys Lys Pro 
        195                 200                 205             


Ile Val Ile Thr Gly His Glu Ile Ile Ser Phe Gly Leu Glu Lys Thr 
    210                 215                 220                 


Val Thr Gln Phe Ile Ser Lys Thr Lys Leu Pro Ile Thr Thr Leu Asn 
225                 230                 235                 240 


Phe Gly Lys Ser Ser Val Asp Glu Ala Leu Pro Ser Phe Leu Gly Ile 
                245                 250                 255     


Tyr Asn Gly Thr Leu Ser Glu Pro Asn Leu Lys Glu Phe Val Glu Ser 
            260                 265                 270         


Ala Asp Phe Ile Leu Met Leu Gly Val Lys Leu Thr Asp Ser Ser Thr 
        275                 280                 285             


Gly Ala Phe Thr His His Leu Asn Glu Asn Lys Met Ile Ser Leu Asn 
    290                 295                 300                 


Ile Asp Glu Gly Lys Ile Phe Asn Glu Arg Ile Gln Asn Phe Asp Phe 
305                 310                 315                 320 


Glu Ser Leu Ile Ser Ser Leu Leu Asp Leu Ser Glu Ile Glu Tyr Lys 
                325                 330                 335     


Gly Lys Tyr Ile Asp Lys Lys Gln Glu Asp Phe Val Pro Ser Asn Ala 
            340                 345                 350         


Leu Leu Ser Gln Asp Arg Leu Trp Gln Ala Val Glu Asn Leu Thr Gln 
        355                 360                 365             


Ser Asn Glu Thr Ile Val Ala Glu Gln Gly Thr Ser Phe Phe Gly Ala 
    370                 375                 380                 


Ser Ser Ile Phe Leu Lys Ser Lys Ser His Phe Ile Gly Gln Pro Leu 
385                 390                 395                 400 


Trp Gly Ser Ile Gly Tyr Thr Phe Pro Ala Ala Leu Gly Ser Gln Ile 
                405                 410                 415     


Ala Asp Lys Glu Ser Arg His Leu Leu Phe Ile Gly Asp Gly Ser Leu 
            420                 425                 430         


Gln Leu Thr Val Gln Glu Leu Gly Leu Ala Ile Arg Glu Lys Ile Asn 
        435                 440                 445             


Pro Ile Cys Phe Ile Ile Asn Asn Asp Gly Tyr Thr Val Glu Arg Glu 
    450                 455                 460                 


Ile His Gly Pro Asn Gln Ser Tyr Asn Asp Ile Pro Met Trp Asn Tyr 
465                 470                 475                 480 


Ser Lys Leu Pro Glu Ser Phe Gly Ala Thr Glu Asp Arg Val Val Ser 
                485                 490                 495     


Lys Ile Val Arg Thr Glu Asn Glu Phe Val Ser Val Met Lys Glu Ala 
            500                 505                 510         


Gln Ala Asp Pro Asn Arg Met Tyr Trp Ile Glu Leu Ile Leu Ala Lys 
        515                 520                 525             


Glu Gly Ala Pro Lys Val Leu Lys Lys Met Gly Lys Leu Phe Ala Glu 
    530                 535                 540                 


Gln Asn Lys Ser 
545             


<210>  21
<211>  2145
<212>  DNA
<213>  artificial sequence

<220>
<223>  constructed chimeric gene

<400>  21
gcatgcttgc atttagtcgt gcaatgtatg actttaagat ttgtgagcag gaagaaaagg       60

gagaatcttc taacgataaa cccttgaaaa actgggtaga ctacgctatg ttgagttgct      120

acgcaggctg cacaattaca cgagaatgct cccgcctagg atttaaggct aagggacgtg      180

caatgcagac gacagatcta aatgaccgtg tcggtgaagt gttcgccaaa cttttcggtt      240

aacacatgca gtgatgcacg cgcgatggtg ctaagttaca tatatatata tatatatata      300

tatagccata gtgatgtcta agtaaccttt atggtatatt tcttaatgtg gaaagatact      360

agcgcgcgca cccacacaca agcttcgtct tttcttgaag aaaagaggaa gctcgctaaa      420

tgggattcca ctttccgttc cctgccagct gatggaaaaa ggttagtgga acgatgaaga      480

ataaaaagag agatccactg aggtgaaatt tcagctgaca gcgagtttca tgatcgtgat      540

gaacaatggt aacgagttgt ggctgttgcc agggagggtg gttctcaact tttaatgtat      600

ggccaaatcg ctacttgggt ttgttatata acaaagaaga aataatgaac tgattctctt      660

cctccttctt gtcctttctt aattctgttg taattacctt cctttgtaat tttttttgta      720

attattcttc ttaataatcc aaacaaacac acatattaca atagctagct gaggatgaag      780

gcattagttt atcatgggga tcacaaaatt tcgttagaag acaaaccaaa acccactctg      840

cagaaaccaa cagacgttgt ggttagggtg ttgaaaacaa caatttgcgg tactgacttg      900

ggaatataca aaggtaagaa tcctgaagtg gcagatggca gaatcctggg tcatgagggc      960

gttggcgtca ttgaagaagt gggcgaatcc gtgacacaat tcaaaaaggg ggataaagtt     1020

ttaatctcct gcgttactag ctgtggatcg tgtgattatt gcaagaagca actgtattca     1080

cactgtagag acggtggctg gattttaggt tacatgatcg acggtgtcca agccgaatac     1140

gtcagaatac cacatgctga caattcattg tataagatcc cgcaaactat cgatgatgaa     1200

attgcagtac tactgtccga tattttacct actggacatg aaattggtgt tcaatatggt     1260

aacgttcaac caggcgatgc tgtagcaatt gtaggagcag gtcctgttgg aatgtcagtt     1320

ttgttaactg ctcaatttta ctcgcctagt accattattg ttatcgacat ggacgaaaac     1380

cgtttacaat tagcgaagga gcttggggcc acacacacta ttaactccgg tactgaaaat     1440

gttgtcgaag ctgtgcatcg tatagcagcc gaaggagtgg atgtagcaat agaagctgtt     1500

ggtatacccg caacctggga catctgtcag gaaattgtaa aacccggcgc tcatattgcc     1560

aacgtgggag ttcatggtgt taaggtggac tttgaaattc aaaagttgtg gattaagaat     1620

ctaaccatca ccactggttt ggttaacact aatactaccc caatgttgat gaaggtagcc     1680

tctactgata aattgccttt aaagaaaatg attactcaca ggtttgagtt agctgaaatc     1740

gaacacgcat atcaggtttt cttgaatggc gctaaagaaa aagctatgaa gattattcta     1800

tctaatgcag gtgccgccta attaattaag agtaagcgaa tttcttatga tttatgattt     1860

ttattattaa ataagttata aaaaaaataa gtgtatacaa attttaaagt gactcttagg     1920

ttttaaaacg aaaattctta ttcttgagta actctttcct gtaggtcagg ttgctttctc     1980

aggtatagca tgaggtcgct cttattgacc acacctctac cggcatgccg agcaaatgcc     2040

tgcaaatcgc tccccatttc acccaattgt agatatgcta actccagcaa tgagttgatg     2100

aatctcggtg tgtattttat gtcctcagag gacaacacct gtggt                     2145


<210>  22
<211>  4280
<212>  DNA
<213>  artificial sequence

<220>
<223>  vector

<400>  22
ggggatcctc tagagtcgac ctgcaggcat gcaagcttgg cgtaatcatg gtcatagctg       60

tttcctgtgt gaaattgtta tccgctcaca attccacaca acatacgagc cggaagcata      120

aagtgtaaag cctggggtgc ctaatgagtg agctaactca cattaattgc gttgcgctca      180

ctgcccgctt tccagtcggg aaacctgtcg tgccagctgc attaatgaat cggccaacgc      240

gcggggagag gcggtttgcg tattgggcgc tcttccgctt cctcgctcac tgactcgctg      300

cgctcggtcg ttcggctgcg gcgagcggta tcagctcact caaaggcggt aatacggtta      360

tccacagaat caggggataa cgcaggaaag aacatgtgag caaaaggcca gcaaaaggcc      420

aggaaccgta aaaaggccgc gttgctggcg tttttccata ggctccgccc ccctgacgag      480

catcacaaaa atcgacgctc aagtcagagg tggcgaaacc cgacaggact ataaagatac      540

caggcgtttc cccctggaag ctccctcgtg cgctctcctg ttccgaccct gccgcttacc      600

ggatacctgt ccgcctttct cccttcggga agcgtggcgc tttctcatag ctcacgctgt      660

aggtatctca gttcggtgta ggtcgttcgc tccaagctgg gctgtgtgca cgaacccccc      720

gttcagcccg accgctgcgc cttatccggt aactatcgtc ttgagtccaa cccggtaaga      780

cacgacttat cgccactggc agcagccact ggtaacagga ttagcagagc gaggtatgta      840

ggcggtgcta cagagttctt gaagtggtgg cctaactacg gctacactag aaggacagta      900

tttggtatct gcgctctgct gaagccagtt accttcggaa aaagagttgg tagctcttga      960

tccggcaaac aaaccaccgc tggtagcggt ggtttttttg tttgcaagca gcagattacg     1020

cgcagaaaaa aaggatctca agaagatcct ttgatctttt ctacggggtc tgacgctcag     1080

tggaacgaaa actcacgtta agggattttg gtcatgagat tatcaaaaag gatcttcacc     1140

tagatccttt taaattaaaa atgaagtttt aaatcaatct aaagtatata tgagtaaact     1200

tggtctgaca gttaccaatg cttaatcagt gaggcaccta tctcagcgat ctgtctattt     1260

cgttcatcca tagttgcctg actccccgtc gtgtagataa ctacgatacg ggagggctta     1320

ccatctggcc ccagtgctgc aatgataccg cgagacccac gctcaccggc tccagattta     1380

tcagcaataa accagccagc cggaagggcc gagcgcagaa gtggtcctgc aactttatcc     1440

gcctccatcc agtctattaa ttgttgccgg gaagctagag taagtagttc gccagttaat     1500

agtttgcgca acgttgttgc cattgctaca ggcatcgtgg tgtcacgctc gtcgtttggt     1560

atggcttcat tcagctccgg ttcccaacga tcaaggcgag ttacatgatc ccccatgttg     1620

tgcaaaaaag cggttagctc cttcggtcct ccgatcgttg tcagaagtaa gttggccgca     1680

gtgttatcac tcatggttat ggcagcactg cataattctc ttactgtcat gccatccgta     1740

agatgctttt ctgtgactgg tgagtactca accaagtcat tctgagaata gtgtatgcgg     1800

cgaccgagtt gctcttgccc ggcgtcaata cgggataata ccgcgccaca tagcagaact     1860

ttaaaagtgc tcatcattgg aaaacgttct tcggggcgaa aactctcaag gatcttaccg     1920

ctgttgagat ccagttcgat gtaacccact cgtgcaccca actgatcttc agcatctttt     1980

actttcacca gcgtttctgg gtgagcaaaa acaggaaggc aaaatgccgc aaaaaaggga     2040

ataagggcga cacggaaatg ttgaatactc atactcttcc tttttcaata ttattgaagc     2100

atttatcagg gttattgtct catgagcgga tacatatttg aatgtattta gaaaaataaa     2160

caaatagggg ttccgcgcac atttccccga aaagtgccac ctgacgtcta agaaaccatt     2220

attatcatga cattaaccta taaaaatagg cgtatcacga ggccctttcg tctcgcgcgt     2280

ttcggtgatg acggtgaaaa cctctgacac atgcagctcc cggagacggt cacagcttgt     2340

ctgtaagcgg atgccgggag cagacaagcc cgtcagggcg cgtcagcggg tgttggcggg     2400

tgtcggggct ggcttaacta tgcggcatca gagcagattg tactgagagt gcaccatatg     2460

cggtgtgaaa taccgcacag atgcgtaagg agaaaatacc gcatcaggcg ccattcgcca     2520

ttcaggctgc gcaactgttg ggaagggcga tcggtgcggg cctcttcgct attacgccag     2580

ctggcgaaag ggggatgtgc tgcaaggcga ttaagttggg taacgccagg gttttcccag     2640

tcacgacgtt gtaaaacgac ggccagtgaa ttcgagctcg gtacccccgg ctctgagaca     2700

gtagtaggtt agtcatcgct ctaccgacgc gcaggaaaag aaagaagcat tgcggattac     2760

gtattctaat gttcagcccg cggaacgcca gcaaatcacc acccatgcgc atgatactga     2820

gtcttgtaca cgctgggctt ccagtgtact gagagtgcac cataccacag cttttcaatt     2880

caattcatca tttttttttt attctttttt ttgatttcgg tttctttgaa atttttttga     2940

ttcggtaatc tccgaacaga aggaagaacg aaggaaggag cacagactta gattggtata     3000

tatacgcata tgtagtgttg aagaaacatg aaattgccca gtattcttaa cccaactgca     3060

cagaacaaaa acctgcagga aacgaagata aatcatgtcg aaagctacat ataaggaacg     3120

tgctgctact catcctagtc ctgttgctgc caagctattt aatatcatgc acgaaaagca     3180

aacaaacttg tgtgcttcat tggatgttcg taccaccaag gaattactgg agttagttga     3240

agcattaggt cccaaaattt gtttactaaa aacacatgtg gatatcttga ctgatttttc     3300

catggagggc acagttaagc cgctaaaggc attatccgcc aagtacaatt ttttactctt     3360

cgaagacaga aaatttgctg acattggtaa tacagtcaaa ttgcagtact ctgcgggtgt     3420

atacagaata gcagaatggg cagacattac gaatgcacac ggtgtggtgg gcccaggtat     3480

tgttagcggt ttgaagcagg cggcagaaga agtaacaaag gaacctagag gccttttgat     3540

gttagcagaa ttgtcatgca agggctccct atctactgga gaatatacta agggtactgt     3600

tgacattgcg aagagcgaca aagattttgt tatcggcttt attgctcaaa gagacatggg     3660

tggaagagat gaaggttacg attggttgat tatgacaccc ggtgtgggtt tagatgacaa     3720

gggagacgca ttgggtcaac agtatagaac cgtggatgat gtggtctcta caggatctga     3780

cattattatt gttggaagag gactatttgc aaagggaagg gatgctaagg tagagggtga     3840

acgttacaga aaagcaggct gggaagcata tttgagaaga tgcggccagc aaaactaaaa     3900

aactgtatta taagtaaatg catgtatact aaactcacaa attagagctt caatttaatt     3960

atatcagtta ttaccctatg cggtgtgaaa taccgcacag atgcgtaagg agaaaatacc     4020

gcatcaggaa attgtaaacg ttaatatttt gttaaaattc gcgttaaatt tttgttaaat     4080

cagctcattt tttaaccaat aggccgaaat cggcaaaatc ttcagcccgc ggaacgccag     4140

caaatcacca cccatgcgca tgatactgag tcttgtacac gctgggcttc cagtgatgat     4200

acaacgagtt agccaaggtg agcacggatg tctaaattag aattacgttt taatatcttt     4260

ttttccatat ctagggctag                                                 4280


<210>  23
<211>  30
<212>  DNA
<213>  artificial sequence

<220>
<223>  primer

<400>  23
gcatgcttgc atttagtcgt gcaatgtatg                                        30


<210>  24
<211>  54
<212>  DNA
<213>  artificial sequence

<220>
<223>  primer

<400>  24
gaacattaga atacgtaatc cgcaatgcac tagtaccaca ggtgttgtcc tctg             54


<210>  25
<211>  54
<212>  DNA
<213>  artificial sequence

<220>
<223>  primer

<400>  25
cagaggacaa cacctgtggt actagtgcat tgcggattac gtattctaat gttc             54


<210>  26
<211>  28
<212>  DNA
<213>  artificial sequence

<220>
<223>  primer

<400>  26
caccttggct aactcgttgt atcatcac                                          28


<210>  27
<211>  100
<212>  DNA
<213>  artificial sequence

<220>
<223>  primer

<400>  27
ttttaagccg aatgagtgac agaaaaagcc cacaacttat caagtgatat tgaacaaagg       60

gcgaaacttc gcatgcttgc atttagtcgt gcaatgtatg                            100


<210>  28
<211>  98
<212>  DNA
<213>  artificial sequence

<220>
<223>  primer

<400>  28
cccaattggt aaatattcaa caagagacgc gcagtacgta acatgcgaat tgcgtaattc       60

acggcgataa caccttggct aactcgttgt atcatcac                               98


<210>  29
<211>  28
<212>  DNA
<213>  artificial sequence

<220>
<223>  primer

<400>  29
tcggtttttg caatatgacc tgtgggcc                                          28


<210>  30
<211>  29
<212>  DNA
<213>  artificial sequence

<220>
<223>  primer

<400>  30
caaaagccca tgtcccacac caaaggatg                                         29


<210>  31
<211>  26
<212>  DNA
<213>  artificial sequence

<220>
<223>  primer

<400>  31
caccatcgcg cgtgcatcac tgcatg                                            26


<210>  32
<211>  22
<212>  DNA
<213>  artificial sequence

<220>
<223>  primer

<400>  32
gagaagatgc ggccagcaaa ac                                                22


<210>  33
<211>  2745
<212>  DNA
<213>  artificial sequence

<220>
<223>  constructed coding region-terminator segment

<400>  33
atgactgaca aaaaaactct taaagactta agaaatcgta gttctgttta cgattcaatg       60

gttaaatcac ctaatcgtgc tatgttgcgt gcaactggta tgcaagatga agactttgaa      120

aaacctatcg tcggtgtcat ttcaacttgg gctgaaaaca caccttgtaa tatccactta      180

catgactttg gtaaactagc caaagtcggt gttaaggaag ctggtgcttg gccagttcag      240

ttcggaacaa tcacggtttc tgatggaatc gccatgggaa cccaaggaat gcgtttctcc      300

ttgacatctc gtgatattat tgcagattct attgaagcag ccatgggagg tcataatgcg      360

gatgcttttg tagccattgg cggttgtgat aaaaacatgc ccggttctgt tatcgctatg      420

gctaacatgg atatcccagc catttttgct tacggcggaa caattgcacc tggtaattta      480

gacggcaaag atatcgattt agtctctgtc tttgaaggtg tcggccattg gaaccacggc      540

gatatgacca aagaagaagt taaagctttg gaatgtaatg cttgtcccgg tcctggaggc      600

tgcggtggta tgtatactgc taacacaatg gcgacagcta ttgaagtttt gggacttagc      660

cttccgggtt catcttctca cccggctgaa tccgcagaaa agaaagcaga tattgaagaa      720

gctggtcgcg ctgttgtcaa aatgctcgaa atgggcttaa aaccttctga cattttaacg      780

cgtgaagctt ttgaagatgc tattactgta actatggctc tgggaggttc aaccaactca      840

acccttcacc tcttagctat tgcccatgct gctaatgtgg aattgacact tgatgatttc      900

aatactttcc aagaaaaagt tcctcatttg gctgatttga aaccttctgg tcaatatgta      960

ttccaagacc tttacaaggt cggaggggta ccagcagtta tgaaatatct ccttaaaaat     1020

ggcttccttc atggtgaccg tatcacttgt actggcaaaa cagtcgctga aaatttgaag     1080

gcttttgatg atttaacacc tggtcaaaag gttattatgc cgcttgaaaa tcctaaacgt     1140

gaagatggtc cgctcattat tctccatggt aacttggctc cagacggtgc cgttgccaaa     1200

gtttctggtg taaaagtgcg tcgtcatgtc ggtcctgcta aggtctttaa ttctgaagaa     1260

gaagccattg aagctgtctt gaatgatgat attgttgatg gtgatgttgt tgtcgtacgt     1320

tttgtaggac caaagggcgg tcctggtatg cctgaaatgc tttccctttc atcaatgatt     1380

gttggtaaag ggcaaggtga aaaagttgcc cttctgacag atggccgctt ctcaggtggt     1440

acttatggtc ttgtcgtggg tcatatcgct cctgaagcac aagatggcgg tccaatcgcc     1500

tacctgcaaa caggagacat agtcactatt gaccaagaca ctaaggaatt acactttgat     1560

atctccgatg aagagttaaa acatcgtcaa gagaccattg aattgccacc gctctattca     1620

cgcggtatcc ttggtaaata tgctcacatc gtttcgtctg cttctagggg agccgtaaca     1680

gacttttgga agcctgaaga aactggcaaa aaatgttgtc ctggttgctg tggttaagcg     1740

gccgcgttaa ttcaaattaa ttgatatagt tttttaatga gtattgaatc tgtttagaaa     1800

taatggaata ttatttttat ttatttattt atattattgg tcggctcttt tcttctgaag     1860

gtcaatgaca aaatgatatg aaggaaataa tgatttctaa aattttacaa cgtaagatat     1920

ttttacaaaa gcctagctca tcttttgtca tgcactattt tactcacgct tgaaattaac     1980

ggccagtcca ctgcggagtc atttcaaagt catcctaatc gatctatcgt ttttgatagc     2040

tcattttgga gttcgcgatt gtcttctgtt attcacaact gttttaattt ttatttcatt     2100

ctggaactct tcgagttctt tgtaaagtct ttcatagtag cttactttat cctccaacat     2160

atttaacttc atgtcaattt cggctcttaa attttccaca tcatcaagtt caacatcatc     2220

ttttaacttg aatttattct ctagctcttc caaccaagcc tcattgctcc ttgatttact     2280

ggtgaaaagt gatacacttt gcgcgcaatc caggtcaaaa ctttcctgca aagaattcac     2340

caatttctcg acatcatagt acaatttgtt ttgttctccc atcacaattt aatatacctg     2400

atggattctt atgaagcgct gggtaatgga cgtgtcactc tacttcgcct ttttccctac     2460

tccttttagt acggaagaca atgctaataa ataagagggt aataataata ttattaatcg     2520

gcaaaaaaga ttaaacgcca agcgtttaat tatcagaaag caaacgtcgt accaatcctt     2580

gaatgcttcc caattgtata ttaagagtca tcacagcaac atattcttgt tattaaatta     2640

attattattg atttttgata ttgtataaaa aaaccaaata tgtataaaaa aagtgaataa     2700

aaaataccaa gtatggagaa atatattaga agtctatacg ttaaa                     2745


<210>  34
<211>  99
<212>  DNA
<213>  artificial sequence

<220>
<223>  primer

<400>  34
tcctttctca attattattt tctactcata acctcacgca aaataacaca gtcaaatcaa       60

tcaaagtatg actgacaaaa aaactcttaa agacttaag                              99


<210>  35
<211>  77
<212>  DNA
<213>  artificial sequence

<220>
<223>  primer

<400>  35
gaacattaga atacgtaatc cgcaatgctt ctttcttttc cgtttaacgt atagacttct       60

aatatatttc tccatac                                                      77


<210>  36
<211>  45
<212>  DNA
<213>  artificial sequence

<220>
<223>  primer

<400>  36
aaacggaaaa gaaagaagca ttgcggatta cgtattctaa tgttc                       45


<210>  37
<211>  88
<212>  DNA
<213>  artificial sequence

<220>
<223>  primer

<400>  37
tatttttcgt tacataaaaa tgcttataaa actttaacta ataattagag attaaatcgc       60

caccttggct aactcgttgt atcatcac                                          88


<210>  38
<211>  27
<212>  DNA
<213>  artificial sequence

<220>
<223>  primer

<400>  38
gacttttgga agcctgaaga aactggc                                           27


<210>  39
<211>  20
<212>  DNA
<213>  artificial sequence

<220>
<223>  primer

<400>  39
cttggcagca acaggactag                                                   20


<210>  40
<211>  26
<212>  DNA
<213>  artificial sequence

<220>
<223>  primer

<400>  40
ccaggccaat tcaacagact gtcggc                                            26


<210>  41
<211>  2347
<212>  DNA
<213>  artificial sequence

<220>
<223>  constructed URA3 marker with flanking homologous repeat sequences
       for HIS gene replacement and marker excision

<400>  41
gcattgcgga ttacgtattc taatgttcag gtgctggaag aagagctgct taaccgccgc       60

gcccagggtg aagatccacg ctactttacc ctgcgtcgtc tggatttcgg cggctgtcgt      120

ctttcgctgg caacgccggt tgatgaagcc tgggacggtc cgctctcctt aaacggtaaa      180

cgtatcgcca cctcttatcc tcacctgctc aagcgttatc tcgaccagaa aggcatctct      240

tttaaatcct gcttactgaa cggttctgtt gaagtcgccc cgcgtgccgg actggcggat      300

gcgatttgcg atctggtttc caccggtgcc acgctggaag ctaacggcct gcgcgaagtc      360

gaagttatct atcgctcgaa agcctgcctg attcaacgcg atggcgaaat ggaagaatcc      420

aaacagcaac tgatcgacaa actgctgacc cgtattcagg gtgtgatcca ggcgcgcgaa      480

tcaaaataca tcatgatgca cgcaccgacc gaacgtctgg atgaagtcat ggtacctact      540

gagagtgcac cataccacag cttttcaatt caattcatca tttttttttt attctttttt      600

ttgatttcgg tttctttgaa atttttttga ttcggtaatc tccgaacaga aggaagaacg      660

aaggaaggag cacagactta gattggtata tatacgcata tgtagtgttg aagaaacatg      720

aaattgccca gtattcttaa cccaactgca cagaacaaaa acctgcagga aacgaagata      780

aatcatgtcg aaagctacat ataaggaacg tgctgctact catcctagtc ctgttgctgc      840

caagctattt aatatcatgc acgaaaagca aacaaacttg tgtgcttcat tggatgttcg      900

taccaccaag gaattactgg agttagttga agcattaggt cccaaaattt gtttactaaa      960

aacacatgtg gatatcttga ctgatttttc catggagggc acagttaagc cgctaaaggc     1020

attatccgcc aagtacaatt ttttactctt cgaagacaga aaatttgctg acattggtaa     1080

tacagtcaaa ttgcagtact ctgcgggtgt atacagaata gcagaatggg cagacattac     1140

gaatgcacac ggtgtggtgg gcccaggtat tgttagcggt ttgaagcagg cggcagaaga     1200

agtaacaaag gaacctagag gccttttgat gttagcagaa ttgtcatgca agggctccct     1260

atctactgga gaatatacta agggtactgt tgacattgcg aagagcgaca aagattttgt     1320

tatcggcttt attgctcaaa gagacatggg tggaagagat gaaggttacg attggttgat     1380

tatgacaccc ggtgtgggtt tagatgacaa gggagacgca ttgggtcaac agtatagaac     1440

cgtggatgat gtggtctcta caggatctga cattattatt gttggaagag gactatttgc     1500

aaagggaagg gatgctaagg tagagggtga acgttacaga aaagcaggct gggaagcata     1560

tttgagaaga tgcggccagc aaaactaaaa aactgtatta taagtaaatg catgtatact     1620

aaactcacaa attagagctt caatttaatt atatcagtta ttaccctatg cggtgtgaaa     1680

taccgcacag atgcgtaagg agaaaatacc gcatcaggaa attgtaaacg ttaatatttt     1740

gttaaaattc gcgttaaatt tttgttaaat cagctcattt tttaaccaat aggccgaaat     1800

cggcaaaatc tctagagtgc tggaagaaga gctgcttaac cgccgcgccc agggtgaaga     1860

tccacgctac tttaccctgc gtcgtctgga tttcggcggc tgtcgtcttt cgctggcaac     1920

gccggttgat gaagcctggg acggtccgct ctccttaaac ggtaaacgta tcgccacctc     1980

ttatcctcac ctgctcaagc gttatctcga ccagaaaggc atctctttta aatcctgctt     2040

actgaacggt tctgttgaag tcgccccgcg tgccggactg gcggatgcga tttgcgatct     2100

ggtttccacc ggtgccacgc tggaagctaa cggcctgcgc gaagtcgaag ttatctatcg     2160

ctcgaaagcc tgcctgattc aacgcgatgg cgaaatggaa gaatccaaac agcaactgat     2220

cgacaaactg ctgacccgta ttcagggtgt gatccaggcg cgcgaatcaa aatacatcat     2280

gatgcacgca ccgaccgaac gtctggatga agtcatccag tgatgataca acgagttagc     2340

caaggtg                                                               2347


<210>  42
<211>  80
<212>  DNA
<213>  artificial sequence

<220>
<223>  primer

<400>  42
cttcgaagaa tatactaaaa aatgagcagg caagataaac gaaggcaaag gcattgcgga       60

ttacgtattc taatgttcag                                                   80


<210>  43
<211>  80
<212>  DNA
<213>  artificial sequence

<220>
<223>  primer

<400>  43
cttcgaagaa tatactaaaa aatgagcagg caagataaac gaaggcaaag gcattgcgga       60

ttacgtattc taatgttcag                                                   80


<210>  44
<211>  26
<212>  DNA
<213>  artificial sequence

<220>
<223>  primer

<400>  44
gacttgaata atgcagcggc gcttgc                                            26


<210>  45
<211>  30
<212>  DNA
<213>  artificial sequence

<220>
<223>  primer

<400>  45
ccaccctctt caattagcta agatcatagc                                        30


<210>  46
<211>  25
<212>  DNA
<213>  artificial sequence

<220>
<223>  primer

<400>  46
aaaaattgat tctcatcgta aatgc                                             25


<210>  47
<211>  20
<212>  DNA
<213>  artificial sequence

<220>
<223>  primer

<400>  47
ctgcagcgag gagccgtaat                                                   20


<210>  48
<211>  16387
<212>  DNA
<213>  artificial sequence

<220>
<223>  plasmid construct

<400>  48
tcccattacc gacatttggg cgctatacgt gcatatgttc atgtatgtat ctgtatttaa       60

aacacttttg tattattttt cctcatatat gtgtataggt ttatacggat gatttaatta      120

ttacttcacc accctttatt tcaggctgat atcttagcct tgttactagt tagaaaaaga      180

catttttgct gtcagtcact gtcaagagat tcttttgctg gcatttcttc tagaagcaaa      240

aagagcgatg cgtcttttcc gctgaaccgt tccagcaaaa aagactacca acgcaatatg      300

gattgtcaga atcatataaa agagaagcaa ataactcctt gtcttgtatc aattgcatta      360

taatatcttc ttgttagtgc aatatcatat agaagtcatc gaaatagata ttaagaaaaa      420

caaactgtac aatcaatcaa tcaatcatcg ctgaggatgt tgacaaaagc aacaaaagaa      480

caaaaatccc ttgtgaaaaa cagaggggcg gagcttgttg ttgattgctt agtggagcaa      540

ggtgtcacac atgtatttgg cattccaggt gcaaaaattg atgcggtatt tgacgcttta      600

caagataaag gacctgaaat tatcgttgcc cggcacgaac aaaacgcagc attcatggcc      660

caagcagtcg gccgtttaac tggaaaaccg ggagtcgtgt tagtcacatc aggaccgggt      720

gcctctaact tggcaacagg cctgctgaca gcgaacactg aaggagaccc tgtcgttgcg      780

cttgctggaa acgtgatccg tgcagatcgt ttaaaacgga cacatcaatc tttggataat      840

gcggcgctat tccagccgat tacaaaatac agtgtagaag ttcaagatgt aaaaaatata      900

ccggaagctg ttacaaatgc atttaggata gcgtcagcag ggcaggctgg ggccgctttt      960

gtgagctttc cgcaagatgt tgtgaatgaa gtcacaaata cgaaaaacgt gcgtgctgtt     1020

gcagcgccaa aactcggtcc tgcagcagat gatgcaatca gtgcggccat agcaaaaatc     1080

caaacagcaa aacttcctgt cgttttggtc ggcatgaaag gcggaagacc ggaagcaatt     1140

aaagcggttc gcaagctttt gaaaaaggtt cagcttccat ttgttgaaac atatcaagct     1200

gccggtaccc tttctagaga tttagaggat caatattttg gccgtatcgg tttgttccgc     1260

aaccagcctg gcgatttact gctagagcag gcagatgttg ttctgacgat cggctatgac     1320

ccgattgaat atgatccgaa attctggaat atcaatggag accggacaat tatccattta     1380

gacgagatta tcgctgacat tgatcatgct taccagcctg atcttgaatt gatcggtgac     1440

attccgtcca cgatcaatca tatcgaacac gatgctgtga aagtggaatt tgcagagcgt     1500

gagcagaaaa tcctttctga tttaaaacaa tatatgcatg aaggtgagca ggtgcctgca     1560

gattggaaat cagacagagc gcaccctctt gaaatcgtta aagagttgcg taatgcagtc     1620

gatgatcatg ttacagtaac ttgcgatatc ggttcgcacg ccatttggat gtcacgttat     1680

ttccgcagct acgagccgtt aacattaatg atcagtaacg gtatgcaaac actcggcgtt     1740

gcgcttcctt gggcaatcgg cgcttcattg gtgaaaccgg gagaaaaagt ggtttctgtc     1800

tctggtgacg gcggtttctt attctcagca atggaattag agacagcagt tcgactaaaa     1860

gcaccaattg tacacattgt atggaacgac agcacatatg acatggttgc attccagcaa     1920

ttgaaaaaat ataaccgtac atctgcggtc gatttcggaa atatcgatat cgtgaaatat     1980

gcggaaagct tcggagcaac tggcttgcgc gtagaatcac cagaccagct ggcagatgtt     2040

ctgcgtcaag gcatgaacgc tgaaggtcct gtcatcatcg atgtcccggt tgactacagt     2100

gataacatta atttagcaag tgacaagctt ccgaaagaat tcggggaact catgaaaacg     2160

aaagctctct agttaattaa tcatgtaatt agttatgtca cgcttacatt cacgccctcc     2220

ccccacatcc gctctaaccg aaaaggaagg agttagacaa cctgaagtct aggtccctat     2280

ttattttttt atagttatgt tagtattaag aacgttattt atatttcaaa tttttctttt     2340

ttttctgtac agacgcgtgt acgcatgtaa cattatactg aaaaccttgc ttgagaaggt     2400

tttgggacgc tcgaaggctt taatttgcgg gcggccgctc tagaactagt accacaggtg     2460

ttgtcctctg aggacataaa atacacaccg agattcatca actcattgct ggagttagca     2520

tatctacaat tgggtgaaat ggggagcgat ttgcaggcat ttgctcggca tgccggtaga     2580

ggtgtggtca ataagagcga cctcatgcta tacctgagaa agcaacctga cctacaggaa     2640

agagttactc aagaataaga attttcgttt taaaacctaa gagtcacttt aaaatttgta     2700

tacacttatt ttttttataa cttatttaat aataaaaatc ataaatcata agaaattcgc     2760

ttactcttaa ttaatcaagc atctaaaaca caaccgttgg aagcgttgga aaccaactta     2820

gcatacttgg atagagtacc tcttgtgtaa cgaggtggag gtgcaaccca actttgttta     2880

cgttgagcca tttccttatc agagactaat aggtcaatct tgttattatc agcatcaatg     2940

ataatctcat cgccgtctct gaccaacccg ataggaccac cttcagcggc ttcgggaaca     3000

atgtggccga ttaagaaccc gtgagaacca ccagagaatc taccatcagt caacaatgca     3060

acatctttac ccaaaccgta acccatcaga gcagaggaag gctttagcat ttcaggcata     3120

cctggtgcac ctcttggacc ttcatatctg ataacaacaa cggttttttc acccttcttg     3180

atttcacctc tttccaaggc ttcaataaag gcaccttcct cttcgaacac acgtgctcta     3240

cccttgaagt aagtaccttc cttaccggta attttaccca cagctccacc tggtgccaat     3300

gaaccgtaca gaatttgcaa gtgaccgttg gccttgattg ggtgggagag tggcttaata     3360

atctcttgtc cttcaggtag gcttggtgct ttctttgcac gttctgccaa agtgtcaccg     3420

gtaacagtca ttgtgttacc gtgcaacatg ttgttttcat atagatactt aatcacagat     3480

tgggtaccac caacgttaat caaatcggcc atgacgtatt taccagaagg tttgaagtca     3540

ccgatcaatg gtgtagtatc actgattctt tggaaatcat ctggtgacaa cttgacaccc     3600

gcagagtgag caacagccac caaatgcaaa acagcattag tggacccacc ggttgcaacg     3660

acataagtaa tggcgttttc aaaagcctct tttgtgagga tatcacgagg taaaataccc     3720

aattccattg tcttcttgat gtattcacca atgttgtcac actcagctaa cttctccttg     3780

gaaacggctg ggaaggaaga ggagtttgga atggtcaaac ctagcacttc agcggcagaa     3840

gccattgtgt tggcagtata cataccacca caagaaccag gacctgggca tgcatgttcc     3900

acaacatctt ctctttcttc ttcagtgaat tgcttggaaa tatattcacc gtaggattgg     3960

aacgcagaga cgatatcgat gtttttagag atcctgttaa aacctctagt ggagtagtag     4020

atgtaatcaa tgaagcggaa gccaaaagac cagagtagag gcctatagaa gaaactgcga     4080

taccttttgt gatggctaaa caaacagaca tctttttata tgtttttact tctgtatatc     4140

gtgaagtagt aagtgataag cgaatttggc taagaacgtt gtaagtgaac aagggacctc     4200

ttttgccttt caaaaaagga ttaaatggag ttaatcattg agatttagtt ttcgttagat     4260

tctgtatccc taaataactc ccttacccga cgggaaggca caaaagactt gaataatagc     4320

aaacggccag tagccaagac caaataatac tagagttaac tgatggtctt aaacaggcat     4380

tacgtggtga actccaagac caatatacaa aatatcgata agttattctt gcccaccaat     4440

ttaaggagcc tacatcagga cagtagtacc attcctcaga gaagaggtat acataacaag     4500

aaaatcgcgt gaacacctta tataacttag cccgttattg agctaaaaaa ccttgcaaaa     4560

tttcctatga ataagaatac ttcagacgtg ataaaaattt actttctaac tcttctcacg     4620

ctgcccctat ctgttcttcc gctctaccgt gagaaataaa gcatcgagta cggcagttcg     4680

ctgtcactga actaaaacaa taaggctagt tcgaatgatg aacttgcttg ctgtcaaact     4740

tctgagttgc cgctgatgtg acactgtgac aataaattca aaccggttat agcggtctcc     4800

tccggtaccg gttctgccac ctccaataga gctcagtagg agtcagaacc tctgcggtgg     4860

ctgtcagtga ctcatccgcg tttcgtaagt tgtgcgcgtg cacatttcgc ccgttcccgc     4920

tcatcttgca gcaggcggaa attttcatca cgctgtagga cgcaaaaaaa aaataattaa     4980

tcgtacaaga atcttggaaa aaaaattgaa aaattttgta taaaagggat gacctaactt     5040

gactcaatgg cttttacacc cagtattttc cctttccttg tttgttacaa ttatagaagc     5100

aagacaaaaa catatagaca acctattcct aggagttata tttttttacc ctaccagcaa     5160

tataagtaaa aaactagtat gaaggtgttt tacgataaag actgcgatct gagcatcatc     5220

cagggaaaga aggttgctat tataggatat ggttcccaag gacacgcaca agccttgaac     5280

ttgaaagatt ctggggtcga cgtgacagta ggtctgtata aaggtgctgc tgatgcagca     5340

aaggctgaag cacatggctt taaagtcaca gatgttgcag cggctgttgc tggcgctgat     5400

ttagtcatga ttttaattcc agatgaattt caatcgcaat tgtacaaaaa tgaaatagaa     5460

ccaaacatta agaagggcgc taccttggcc ttcagtcatg gatttgccat tcattacaat     5520

caagtagtcc ccagggcaga tttggacgtt attatgattg cacctaaggc tccggggcat     5580

actgttagga gcgaatttgt taagggtggt ggtattccag atttgatcgc tatataccaa     5640

gacgttagcg gaaacgctaa gaatgtagct ttaagctacg cagcaggagt tggtggcggg     5700

agaacgggta taatagaaac cacttttaaa gacgagactg agacagattt atttggagaa     5760

caagcggttc tgtgcggagg aactgttgaa ttggttaaag caggctttga gacgcttgtc     5820

gaagcagggt acgctcccga aatggcatac ttcgaatgtc tacatgaatt gaagttgata     5880

gtagacttaa tgtatgaagg tggtatagct aatatgaact attccatttc aaataatgca     5940

gaatatggtg agtatgtcac cggacctgaa gtcattaacg cagaatcaag acaagccatg     6000

agaaatgcct tgaaacgtat ccaggacggt gaatacgcta agatgttcat aagtgaaggc     6060

gctacgggtt acccgagtat gactgctaaa agaagaaaca atgcagcaca tggtatcgaa     6120

attattggtg aacagttaag gtctatgatg ccctggatcg gtgctaataa gatcgtagac     6180

aaggcgaaaa attaaggccc tgcaggccta tcaagtgctg gaaacttttt ctcttggaat     6240

ttttgcaaca tcaagtcata gtcaattgaa ttgacccaat ttcacattta agattttttt     6300

tttttcatcc gacatacatc tgtacactag gaagccctgt ttttctgaag cagcttcaaa     6360

tatatatatt ttttacatat ttattatgat tcaatgaaca atctaattaa atcgaaaaca     6420

agaaccgaaa cgcgaataaa taatttattt agatggtgac aagtgtataa gtcctcatcg     6480

ggacagctac gatttctctt tcggttttgg ctgagctact ggttgctgtg acgcagcggc     6540

attagcgcgg cgttatgagc taccctcgtg gcctgaaaga tggcgggaat aaagcggaac     6600

taaaaattac tgactgagcc atattgaggt caatttgtca actcgtcaag tcacgtttgg     6660

tggacggccc ctttccaacg aatcgtatat actaacatgc gcgcgcttcc tatatacaca     6720

tatacatata tatatatata tatatgtgtg cgtgtatgtg tacacctgta tttaatttcc     6780

ttactcgcgg gtttttcttt tttctcaatt cttggcttcc tctttctcga gtatataatt     6840

tttcaggtaa aatttagtac gatagtaaaa tacttctcga actcgtcaca tatacgtgta     6900

cataatgtct gaaccagctc aaaagaaaca aaaggttgct aacaactctc tagagcggcc     6960

gcccgcaaat taaagccttc gagcgtccca aaaccttctc aagcaaggtt ttcagtataa     7020

tgttacatgc gtacacgcgt ctgtacagaa aaaaaagaaa aatttgaaat ataaataacg     7080

ttcttaatac taacataact ataaaaaaat aaatagggac ctagacttca ggttgtctaa     7140

ctccttcctt ttcggttaga gcggatgtgg ggggagggcg tgaatgtaag cgtgacataa     7200

ctaattacat gattaattaa ttattggttt tctggtctca actttctgac ttccttacca     7260

accttccaga tttccatgtt tctgatggtg tctaattcct tttctagctt ttctctgtag     7320

tcaggttgag agttgaattc caaagatctc ttggtttcgg taccgttctt ggtagattcg     7380

tacaagtctt ggaaaacagg cttcaaagca ttcttgaaga ttgggtacca gtccaaagca     7440

cctcttctgg cggtggtgga acaagcatcg tacatgtaat ccataccgta cttaccgatc     7500

aatgggtata gagattgggt agcttcttcg acggtttcgt tgaaagcttc agatggggag     7560

tgaccgtttt ctctcaagac gtcgtattga gccaagaaca taccgtggat accacccatt     7620

aaacaacctc tttcaccgta caagtcagag ttgacttctc tttcgaaagt ggtttggtaa     7680

acgtaaccgg aaccaatggc aacggccaaa gcttgggcct tttcgtgagc cttaccggtg     7740

acatcgttcc agacggcgta agaagagtta ataccacgac cttccttgaa caaagatctg     7800

acagttctac cggaaccctt tggagcaacc aagataacat ctaagtcctt tggtggttca     7860

acgtgagtca agtccttgaa gactggggag aaaccgtggg agaagtacaa agtcttaccc     7920

ttggtcaaca atggcttgat agcaggccag gtttctgatt gagcggcatc ggacaacaag     7980

ttcataacgt aactacctct cttgatagca tcttcaacag tgaacaagtt cttgcctgga     8040

acccaaccgt cttcgatggc agccttccaa gaagcaccat ctttacggac accaatgata     8100

acgttcaaac cgttgtctct caagttcaaa ccttgaccgt aaccttggga accgtaaccg     8160

atcaaagcaa aagtgtcgtt cttgaagtag tccaacaact tttctcttgg ccagtcagct     8220

ctttcgtaga cggtttcaac agtaccaccg aagttgattt gcttcaacat cctcagctct     8280

agatttgaat atgtattact tggttatggt tatatatgac aaaagaaaaa gaagaacaga     8340

agaataacgc aaggaagaac aataactgaa attgatagag aagtattatg tctttgtctt     8400

tttataataa atcaagtgca gaaatccgtt agacaacatg agggataaaa tttaacgtgg     8460

gcgaagaaga aggaaaaaag tttttgtgag ggcgtaattg aagcgatctg ttgattgtag     8520

attttttttt tttgaggagt caaagtcaga agagaacaga caaatggtat taaccatcca     8580

atactttttt ggagcaacgc taagctcatg cttttccatt ggttacgtgc tcagttgtta     8640

gatatggaaa gagaggatgc tcacggcagc gtgactccaa ttgagcccga aagagaggat     8700

gccacgtttt cccgacggct gctagaatgg aaaaaggaaa aatagaagaa tcccattcct     8760

atcattattt acgtaatgac ccacacattt ttgagatttt caactattac gtattacgat     8820

aatcctgctg tcattatcat tattatctat atcgacgtat gcaacgtatg tgaagccaag     8880

taggcaatta tttagtactg tcagtattgt tattcatttc agatctatcc gcggtggagc     8940

tcgaattcac tggccgtcgt tttacaacgt cgtgactggg aaaaccctgg cgttacccaa     9000

cttaatcgcc ttgcagcaca tccccctttc gccagctggc gtaatagcga agaggcccgc     9060

accgatcgcc cttcccaaca gttgcgcagc ctgaatggcg aatggcgcct gatgcggtat     9120

tttctcctta cgcatctgtg cggtatttca caccgcatac gtcaaagcaa ccatagtacg     9180

cgccctgtag cggcgcatta agcgcggcgg gtgtggtggt tacgcgcagc gtgaccgcta     9240

cacttgccag cgccttagcg cccgctcctt tcgctttctt cccttccttt ctcgccacgt     9300

tcgccggctt tccccgtcaa gctctaaatc gggggctccc tttagggttc cgatttagtg     9360

ctttacggca cctcgacccc aaaaaacttg atttgggtga tggttcacgt agtgggccat     9420

cgccctgata gacggttttt cgccctttga cgttggagtc cacgttcttt aatagtggac     9480

tcttgttcca aactggaaca acactcaact ctatctcggg ctattctttt gatttataag     9540

ggattttgcc gatttcggtc tattggttaa aaaatgagct gatttaacaa aaatttaacg     9600

cgaattttaa caaaatatta acgtttacaa ttttatggtg cactctcagt acaatctgct     9660

ctgatgccgc atagttaagc cagccccgac acccgccaac acccgctgac gcgccctgac     9720

gggcttgtct gctcccggca tccgcttaca gacaagctgt gaccgtctcc gggagctgca     9780

tgtgtcagag gttttcaccg tcatcaccga aacgcgcgag acgaaagggc ctcgtgatac     9840

gcctattttt ataggttaat gtcatgataa taatggtttc ttagacgtca ggtggcactt     9900

ttcggggaaa tgtgcgcgga acccctattt gtttattttt ctaaatacat tcaaatatgt     9960

atccgctcat gagacaataa ccctgataaa tgcttcaata atattgaaaa aggaagagta    10020

tgagtattca acatttccgt gtcgccctta ttcccttttt tgcggcattt tgccttcctg    10080

tttttgctca cccagaaacg ctggtgaaag taaaagatgc tgaagatcag ttgggtgcac    10140

gagtgggtta catcgaactg gatctcaaca gcggtaagat ccttgagagt tttcgccccg    10200

aagaacgttt tccaatgatg agcactttta aagttctgct atgtggcgcg gtattatccc    10260

gtattgacgc cgggcaagag caactcggtc gccgcataca ctattctcag aatgacttgg    10320

ttgagtactc accagtcaca gaaaagcatc ttacggatgg catgacagta agagaattat    10380

gcagtgctgc cataaccatg agtgataaca ctgcggccaa cttacttctg acaacgatcg    10440

gaggaccgaa ggagctaacc gcttttttgc acaacatggg ggatcatgta actcgccttg    10500

atcgttggga accggagctg aatgaagcca taccaaacga cgagcgtgac accacgatgc    10560

ctgtagcaat ggcaacaacg ttgcgcaaac tattaactgg cgaactactt actctagctt    10620

cccggcaaca attaatagac tggatggagg cggataaagt tgcaggacca cttctgcgct    10680

cggcccttcc ggctggctgg tttattgctg ataaatctgg agccggtgag cgtgggtctc    10740

gcggtatcat tgcagcactg gggccagatg gtaagccctc ccgtatcgta gttatctaca    10800

cgacggggag tcaggcaact atggatgaac gaaatagaca gatcgctgag ataggtgcct    10860

cactgattaa gcattggtaa ctgtcagacc aagtttactc atatatactt tagattgatt    10920

taaaacttca tttttaattt aaaaggatct aggtgaagat cctttttgat aatctcatga    10980

ccaaaatccc ttaacgtgag ttttcgttcc actgagcgtc agaccccgta gaaaagatca    11040

aaggatcttc ttgagatcct ttttttctgc gcgtaatctg ctgcttgcaa acaaaaaaac    11100

caccgctacc agcggtggtt tgtttgccgg atcaagagct accaactctt tttccgaagg    11160

taactggctt cagcagagcg cagataccaa atactgttct tctagtgtag ccgtagttag    11220

gccaccactt caagaactct gtagcaccgc ctacatacct cgctctgcta atcctgttac    11280

cagtggctgc tgccagtggc gataagtcgt gtcttaccgg gttggactca agacgatagt    11340

taccggataa ggcgcagcgg tcgggctgaa cggggggttc gtgcacacag cccagcttgg    11400

agcgaacgac ctacaccgaa ctgagatacc tacagcgtga gctatgagaa agcgccacgc    11460

ttcccgaagg gagaaaggcg gacaggtatc cggtaagcgg cagggtcgga acaggagagc    11520

gcacgaggga gcttccaggg ggaaacgcct ggtatcttta tagtcctgtc gggtttcgcc    11580

acctctgact tgagcgtcga tttttgtgat gctcgtcagg ggggcggagc ctatggaaaa    11640

acgccagcaa cgcggccttt ttacggttcc tggccttttg ctggcctttt gctcacatgt    11700

tctttcctgc gttatcccct gattctgtgg ataaccgtat taccgccttt gagtgagctg    11760

ataccgctcg ccgcagccga acgaccgagc gcagcgagtc agtgagcgag gaagcggaag    11820

agcgcccaat acgcaaaccg cctctccccg cgcgttggcc gattcattaa tgcagctggc    11880

acgacaggtt tcccgactgg aaagcgggca gtgagcgcaa cgcaattaat gtgagttagc    11940

tcactcatta ggcaccccag gctttacact ttatgcttcc ggctcgtatg ttgtgtggaa    12000

ttgtgagcgg ataacaattt cacacaggaa acagctatga ccatgattac gccaagcttt    12060

ttctttccaa tttttttttt ttcgtcatta taaaaatcat tacgaccgag attcccgggt    12120

aataactgat ataattaaat tgaagctcta atttgtgagt ttagtataca tgcatttact    12180

tataatacag ttttttagtt ttgctggccg catcttctca aatatgcttc ccagcctgct    12240

tttctgtaac gttcaccctc taccttagca tcccttccct ttgcaaatag tcctcttcca    12300

acaataataa tgtcagatcc tgtagagacc acatcatcca cggttctata ctgttgaccc    12360

aatgcgtctc ccttgtcatc taaacccaca ccgggtgtca taatcaacca atcgtaacct    12420

tcatctcttc cacccatgtc tctttgagca ataaagccga taacaaaatc tttgtcgctc    12480

ttcgcaatgt caacagtacc cttagtatat tctccagtag atagggagcc cttgcatgac    12540

aattctgcta acatcaaaag gcctctaggt tcctttgtta cttcttctgc cgcctgcttc    12600

aaaccgctaa caatacctgg gcccaccaca ccgtgtgcat tcgtaatgtc tgcccattct    12660

gctattctgt atacacccgc agagtactgc aatttgactg tattaccaat gtcagcaaat    12720

tttctgtctt cgaagagtaa aaaattgtac ttggcggata atgcctttag cggcttaact    12780

gtgccctcca tggaaaaatc agtcaagata tccacatgtg tttttagtaa acaaattttg    12840

ggacctaatg cttcaactaa ctccagtaat tccttggtgg tacgaacatc caatgaagca    12900

cacaagtttg tttgcttttc gtgcatgata ttaaatagct tggcagcaac aggactagga    12960

tgagtagcag cacgttcctt atatgtagct ttcgacatga tttatcttcg tttcctgcag    13020

gtttttgttc tgtgcagttg ggttaagaat actgggcaat ttcatgtttc ttcaacacta    13080

catatgcgta tatataccaa tctaagtctg tgctccttcc ttcgttcttc cttctgttcg    13140

gagattaccg aatcaaaaaa atttcaagga aaccgaaatc aaaaaaaaga ataaaaaaaa    13200

aatgatgaat tgaaaagctt gcatgcctgc aggtcgactc tagtatactc cgtctactgt    13260

acgatacact tccgctcagg tccttgtcct ttaacgaggc cttaccactc ttttgttact    13320

ctattgatcc agctcagcaa aggcagtgtg atctaagatt ctatcttcgc gatgtagtaa    13380

aactagctag accgagaaag agactagaaa tgcaaaaggc acttctacaa tggctgccat    13440

cattattatc cgatgtgacg ctgcattttt tttttttttt tttttttttt tttttttttt    13500

tttttttttt tttttttgta caaatatcat aaaaaaagag aatcttttta agcaaggatt    13560

ttcttaactt cttcggcgac agcatcaccg acttcggtgg tactgttgga accacctaaa    13620

tcaccagttc tgatacctgc atccaaaacc tttttaactg catcttcaat ggctttacct    13680

tcttcaggca agttcaatga caatttcaac atcattgcag cagacaagat agtggcgata    13740

gggttgacct tattctttgg caaatctgga gcggaaccat ggcatggttc gtacaaacca    13800

aatgcggtgt tcttgtctgg caaagaggcc aaggacgcag atggcaacaa acccaaggag    13860

cctgggataa cggaggcttc atcggagatg atatcaccaa acatgttgct ggtgattata    13920

ataccattta ggtgggttgg gttcttaact aggatcatgg cggcagaatc aatcaattga    13980

tgttgaactt tcaatgtagg gaattcgttc ttgatggttt cctccacagt ttttctccat    14040

aatcttgaag aggccaaaac attagcttta tccaaggacc aaataggcaa tggtggctca    14100

tgttgtaggg ccatgaaagc ggccattctt gtgattcttt gcacttctgg aacggtgtat    14160

tgttcactat cccaagcgac accatcacca tcgtcttcct ttctcttacc aaagtaaata    14220

cctcccacta attctctaac aacaacgaag tcagtacctt tagcaaattg tggcttgatt    14280

ggagataagt ctaaaagaga gtcggatgca aagttacatg gtcttaagtt ggcgtacaat    14340

tgaagttctt tacggatttt tagtaaacct tgttcaggtc taacactacc ggtaccccat    14400

ttaggaccac ccacagcacc taacaaaacg gcatcagcct tcttggaggc ttccagcgcc    14460

tcatctggaa gtggaacacc tgtagcatcg atagcagcac caccaattaa atgattttcg    14520

aaatcgaact tgacattgga acgaacatca gaaatagctt taagaacctt aatggcttcg    14580

gctgtgattt cttgaccaac gtggtcacct ggcaaaacga cgatcttctt aggggcagac    14640

attacaatgg tatatccttg aaatatatat aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa    14700

tgcagcttct caatgatatt cgaatacgct ttgaggagat acagcctaat atccgacaaa    14760

ctgttttaca gatttacgat cgtacttgtt acccatcatt gaattttgaa catccgaacc    14820

tgggagtttt ccctgaaaca gatagtatat ttgaacctgt ataataatat atagtctagc    14880

gctttacgga agacaatgta tgtatttcgg ttcctggaga aactattgca tctattgcat    14940

aggtaatctt gcacgtcgca tccccggttc attttctgcg tttccatctt gcacttcaat    15000

agcatatctt tgttaacgaa gcatctgtgc ttcattttgt agaacaaaaa tgcaacgcga    15060

gagcgctaat ttttcaaaca aagaatctga gctgcatttt tacagaacag aaatgcaacg    15120

cgaaagcgct attttaccaa cgaagaatct gtgcttcatt tttgtaaaac aaaaatgcaa    15180

cgcgagagcg ctaatttttc aaacaaagaa tctgagctgc atttttacag aacagaaatg    15240

caacgcgaga gcgctatttt accaacaaag aatctatact tcttttttgt tctacaaaaa    15300

tgcatcccga gagcgctatt tttctaacaa agcatcttag attacttttt ttctcctttg    15360

tgcgctctat aatgcagtct cttgataact ttttgcactg taggtccgtt aaggttagaa    15420

gaaggctact ttggtgtcta ttttctcttc cataaaaaaa gcctgactcc acttcccgcg    15480

tttactgatt actagcgaag ctgcgggtgc attttttcaa gataaaggca tccccgatta    15540

tattctatac cgatgtggat tgcgcatact ttgtgaacag aaagtgatag cgttgatgat    15600

tcttcattgg tcagaaaatt atgaacggtt tcttctattt tgtctctata tactacgtat    15660

aggaaatgtt tacattttcg tattgttttc gattcactct atgaatagtt cttactacaa    15720

tttttttgtc taaagagtaa tactagagat aaacataaaa aatgtagagg tcgagtttag    15780

atgcaagttc aaggagcgaa aggtggatgg gtaggttata tagggatata gcacagagat    15840

atatagcaaa gagatacttt tgagcaatgt ttgtggaagc ggtattcgca atattttagt    15900

agctcgttac agtccggtgc gtttttggtt ttttgaaagt gcgtcttcag agcgcttttg    15960

gttttcaaaa gcgctctgaa gttcctatac tttctagaga ataggaactt cggaatagga    16020

acttcaaagc gtttccgaaa acgagcgctt ccgaaaatgc aacgcgagct gcgcacatac    16080

agctcactgt tcacgtcgca cctatatctg cgtgttgcct gtatatatat atacatgaga    16140

agaacggcat agtgcgtgtt tatgcttaaa tgcgtactta tatgcgtcta tttatgtagg    16200

atgaaaggta gtctagtacc tcctgtgata ttatcccatt ccatgcgggg tatcgtatgc    16260

ttccttcagc actacccttt agctgttcta tatgctgcca ctcctcaatt ggattagtct    16320

catccttcaa tgctatcatt tcctttgata ttggatcata tgcatagtac cgagaaacta    16380

gaggatc                                                              16387


<210>  49
<211>  448
<212>  DNA
<213>  Saccharomyces cerevisiae

<400>  49
cccattaccg acatttgggc gctatacgtg catatgttca tgtatgtatc tgtatttaaa       60

acacttttgt attatttttc ctcatatatg tgtataggtt tatacggatg atttaattat      120

tacttcacca ccctttattt caggctgata tcttagcctt gttactagtt agaaaaagac      180

atttttgctg tcagtcactg tcaagagatt cttttgctgg catttcttct agaagcaaaa      240

agagcgatgc gtcttttccg ctgaaccgtt ccagcaaaaa agactaccaa cgcaatatgg      300

attgtcagaa tcatataaaa gagaagcaaa taactccttg tcttgtatca attgcattat      360

aatatcttct tgttagtgca atatcatata gaagtcatcg aaatagatat taagaaaaac      420

aaactgtaca atcaatcaat caatcatc                                         448


<210>  50
<211>  250
<212>  DNA
<213>  Saccharomyces cerevisiae

<400>  50
ccgcaaatta aagccttcga gcgtcccaaa accttctcaa gcaaggtttt cagtataatg       60

ttacatgcgt acacgcgtct gtacagaaaa aaaagaaaaa tttgaaatat aaataacgtt      120

cttaatacta acataactat aaaaaaataa atagggacct agacttcagg ttgtctaact      180

ccttcctttt cggttagagc ggatgtgggg ggagggcgtg aatgtaagcg tgacataact      240

aattacatga                                                             250


<210>  51
<211>  1181
<212>  DNA
<213>  Saccharomyces cerevisiae

<400>  51
taaaacctct agtggagtag tagatgtaat caatgaagcg gaagccaaaa gaccagagta       60

gaggcctata gaagaaactg cgataccttt tgtgatggct aaacaaacag acatcttttt      120

atatgttttt acttctgtat atcgtgaagt agtaagtgat aagcgaattt ggctaagaac      180

gttgtaagtg aacaagggac ctcttttgcc tttcaaaaaa ggattaaatg gagttaatca      240

ttgagattta gttttcgtta gattctgtat ccctaaataa ctcccttacc cgacgggaag      300

gcacaaaaga cttgaataat agcaaacggc cagtagccaa gaccaaataa tactagagtt      360

aactgatggt cttaaacagg cattacgtgg tgaactccaa gaccaatata caaaatatcg      420

ataagttatt cttgcccacc aatttaagga gcctacatca ggacagtagt accattcctc      480

agagaagagg tatacataac aagaaaatcg cgtgaacacc ttatataact tagcccgtta      540

ttgagctaaa aaaccttgca aaatttccta tgaataagaa tacttcagac gtgataaaaa      600

tttactttct aactcttctc acgctgcccc tatctgttct tccgctctac cgtgagaaat      660

aaagcatcga gtacggcagt tcgctgtcac tgaactaaaa caataaggct agttcgaatg      720

atgaacttgc ttgctgtcaa acttctgagt tgccgctgat gtgacactgt gacaataaat      780

tcaaaccggt tatagcggtc tcctccggta ccggttctgc cacctccaat agagctcagt      840

aggagtcaga acctctgcgg tggctgtcag tgactcatcc gcgtttcgta agttgtgcgc      900

gtgcacattt cgcccgttcc cgctcatctt gcagcaggcg gaaattttca tcacgctgta      960

ggacgcaaaa aaaaaataat taatcgtaca agaatcttgg aaaaaaaatt gaaaaatttt     1020

gtataaaagg gatgacctaa cttgactcaa tggcttttac acccagtatt ttccctttcc     1080

ttgtttgtta caattataga agcaagacaa aaacatatag acaacctatt cctaggagtt     1140

atattttttt accctaccag caatataagt aaaaaactag t                         1181


<210>  52
<211>  759
<212>  DNA
<213>  Saccharomyces cerevisiae

<400>  52
ggccctgcag gcctatcaag tgctggaaac tttttctctt ggaatttttg caacatcaag       60

tcatagtcaa ttgaattgac ccaatttcac atttaagatt tttttttttt catccgacat      120

acatctgtac actaggaagc cctgtttttc tgaagcagct tcaaatatat atatttttta      180

catatttatt atgattcaat gaacaatcta attaaatcga aaacaagaac cgaaacgcga      240

ataaataatt tatttagatg gtgacaagtg tataagtcct catcgggaca gctacgattt      300

ctctttcggt tttggctgag ctactggttg ctgtgacgca gcggcattag cgcggcgtta      360

tgagctaccc tcgtggcctg aaagatggcg ggaataaagc ggaactaaaa attactgact      420

gagccatatt gaggtcaatt tgtcaactcg tcaagtcacg tttggtggac ggcccctttc      480

caacgaatcg tatatactaa catgcgcgcg cttcctatat acacatatac atatatatat      540

atatatatat gtgtgcgtgt atgtgtacac ctgtatttaa tttccttact cgcgggtttt      600

tcttttttct caattcttgg cttcctcttt ctcgagtata taatttttca ggtaaaattt      660

agtacgatag taaaatactt ctcgaactcg tcacatatac gtgtacataa tgtctgaacc      720

agctcaaaag aaacaaaagg ttgctaacaa ctctctaga                             759


<210>  53
<211>  643
<212>  DNA
<213>  Saccharomyces cerevisiae

<400>  53
gaaatgaata acaatactga cagtactaaa taattgccta cttggcttca catacgttgc       60

atacgtcgat atagataata atgataatga cagcaggatt atcgtaatac gtaatagttg      120

aaaatctcaa aaatgtgtgg gtcattacgt aaataatgat aggaatggga ttcttctatt      180

tttccttttt ccattctagc agccgtcggg aaaacgtggc atcctctctt tcgggctcaa      240

ttggagtcac gctgccgtga gcatcctctc tttccatatc taacaactga gcacgtaacc      300

aatggaaaag catgagctta gcgttgctcc aaaaaagtat tggatggtta ataccatttg      360

tctgttctct tctgactttg actcctcaaa aaaaaaaaat ctacaatcaa cagatcgctt      420

caattacgcc ctcacaaaaa cttttttcct tcttcttcgc ccacgttaaa ttttatccct      480

catgttgtct aacggatttc tgcacttgat ttattataaa aagacaaaga cataatactt      540

ctctatcaat ttcagttatt gttcttcctt gcgttattct tctgttcttc tttttctttt      600

gtcatatata accataacca agtaatacat attcaaatct aga                        643


<210>  54
<211>  270
<212>  DNA
<213>  Saccharomyces cerevisiae

<400>  54
gacctcgagt catgtaatta gttatgtcac gcttacattc acgccctccc cccacatccg       60

ctctaaccga aaaggaagga gttagacaac ctgaagtcta ggtccctatt tattttttta      120

tagttatgtt agtattaaga acgttattta tatttcaaat ttttcttttt tttctgtaca      180

gacgcgtgta cgcatgtaac attatactga aaaccttgct tgagaaggtt ttgggacgct      240

cgaaggcttt aatttgcggc cggtacccaa                                       270


<210>  55
<211>  15539
<212>  DNA
<213>  artificial sequence

<220>
<223>  constructed plasmid

<400>  55
tcgcgcgttt cggtgatgac ggtgaaaacc tctgacacat gcagctcccg gagacggtca       60

cagcttgtct gtaagcggat gccgggagca gacaagcccg tcagggcgcg tcagcgggtg      120

ttggcgggtg tcggggctgg cttaactatg cggcatcaga gcagattgta ctgagagtgc      180

accataaatt cccgttttaa gagcttggtg agcgctagga gtcactgcca ggtatcgttt      240

gaacacggca ttagtcaggg aagtcataac acagtccttt cccgcaattt tctttttcta      300

ttactcttgg cctcctctag tacactctat atttttttat gcctcggtaa tgattttcat      360

tttttttttt ccacctagcg gatgactctt tttttttctt agcgattggc attatcacat      420

aatgaattat acattatata aagtaatgtg atttcttcga agaatatact aaaaaatgag      480

caggcaagat aaacgaaggc aaagatgaca gagcagaaag ccctagtaaa gcgtattaca      540

aatgaaacca agattcagat tgcgatctct ttaaagggtg gtcccctagc gatagagcac      600

tcgatcttcc cagaaaaaga ggcagaagca gtagcagaac aggccacaca atcgcaagtg      660

attaacgtcc acacaggtat agggtttctg gaccatatga tacatgctct ggccaagcat      720

tccggctggt cgctaatcgt tgagtgcatt ggtgacttac acatagacga ccatcacacc      780

actgaagact gcgggattgc tctcggtcaa gcttttaaag aggccctagg ggccgtgcgt      840

ggagtaaaaa ggtttggatc aggatttgcg cctttggatg aggcactttc cagagcggtg      900

gtagatcttt cgaacaggcc gtacgcagtt gtcgaacttg gtttgcaaag ggagaaagta      960

ggagatctct cttgcgagat gatcccgcat tttcttgaaa gctttgcaga ggctagcaga     1020

attaccctcc acgttgattg tctgcgaggc aagaatgatc atcaccgtag tgagagtgcg     1080

ttcaaggctc ttgcggttgc cataagagaa gccacctcgc ccaatggtac caacgatgtt     1140

ccctccacca aaggtgttct tatgtagtga caccgattat ttaaagctgc agcatacgat     1200

atatatacat gtgtatatat gtatacctat gaatgtcagt aagtatgtat acgaacagta     1260

tgatactgaa gatgacaagg taatgcatca ttctatacgt gtcattctga acgaggcgcg     1320

ctttcctttt ttctttttgc tttttctttt tttttctctt gaactcgacg gatctatgcg     1380

gtgtgaaata ccgcacagat gcgtaaggag aaaataccgc atcaggaaat tgtaagcgtt     1440

aatattttgt taaaattcgc gttaaatttt tgttaaatca gctcattttt taaccaatag     1500

gccgaaatcg gcaaaatccc ttataaatca aaagaataga ccgagatagg gttgagtgtt     1560

gttccagttt ggaacaagag tccactatta aagaacgtgg actccaacgt caaagggcga     1620

aaaaccgtct atcagggcga tggcccacta cgtgaaccat caccctaatc aagttttttg     1680

gggtcgaggt gccgtaaagc actaaatcgg aaccctaaag ggagcccccg atttagagct     1740

tgacggggaa agccggcgaa cgtggcgaga aaggaaggga agaaagcgaa aggagcgggc     1800

gctagggcgc tggcaagtgt agcggtcacg ctgcgcgtaa ccaccacacc cgccgcgctt     1860

aatgcgccgc tacagggcgc gtccattcgc cattcaggct gcgcaactgt tgggaagggc     1920

gcggtgcggg cctcttcgct attacgccag ctggcgaaag ggggatgtgc tgcaaggcga     1980

ttaagttggg taacgccagg gttttcccag tcacgacgtt gtaaaacgac ggccagtgag     2040

cgcgcgtaat acgactcact atagggcgaa ttgggtaccg ggccccccct cgaggtcgac     2100

ggcgcgccac tggtagagag cgactttgta tgccccaatt gcgaaacccg cgatatcctt     2160

ctcgattctt tagtacccga ccaggacaag gaaaaggagg tcgaaacgtt tttgaagaaa     2220

caagaggaac tacacggaag ctctaaagat ggcaaccagc cagaaactaa gaaaatgaag     2280

ttgatggatc caactggcac cgctggcttg aacaacaata ccagccttcc aacttctgta     2340

aataacggcg gtacgccagt gccaccagta ccgttacctt tcggtatacc tcctttcccc     2400

atgtttccaa tgcccttcat gcctccaacg gctactatca caaatcctca tcaagctgac     2460

gcaagcccta agaaatgaat aacaatactg acagtactaa ataattgcct acttggcttc     2520

acatacgttg catacgtcga tatagataat aatgataatg acagcaggat tatcgtaata     2580

cgtaatagct gaaaatctca aaaatgtgtg ggtcattacg taaataatga taggaatggg     2640

attcttctat ttttcctttt tccattctag cagccgtcgg gaaaacgtgg catcctctct     2700

ttcgggctca attggagtca cgctgccgtg agcatcctct ctttccatat ctaacaactg     2760

agcacgtaac caatggaaaa gcatgagctt agcgttgctc caaaaaagta ttggatggtt     2820

aataccattt gtctgttctc ttctgacttt gactcctcaa aaaaaaaaat ctacaatcaa     2880

cagatcgctt caattacgcc ctcacaaaaa cttttttcct tcttcttcgc ccacgttaaa     2940

ttttatccct catgttgtct aacggatttc tgcacttgat ttattataaa aagacaaaga     3000

cataatactt ctctatcaat ttcagttatt gttcttcctt gcgttattct tctgttcttc     3060

tttttctttt gtcatatata accataacca agtaatacat attcaaacta gtatgactga     3120

caaaaaaact cttaaagact taagaaatcg tagttctgtt tacgattcaa tggttaaatc     3180

acctaatcgt gctatgttgc gtgcaactgg tatgcaagat gaagactttg aaaaacctat     3240

cgtcggtgtc atttcaactt gggctgaaaa cacaccttgt aatatccact tacatgactt     3300

tggtaaacta gccaaagtcg gtgttaagga agctggtgct tggccagttc agttcggaac     3360

aatcacggtt tctgatggaa tcgccatggg aacccaagga atgcgtttct ccttgacatc     3420

tcgtgatatt attgcagatt ctattgaagc agccatggga ggtcataatg cggatgcttt     3480

tgtagccatt ggcggttgtg ataaaaacat gcccggttct gttatcgcta tggctaacat     3540

ggatatccca gccatttttg cttacggcgg aacaattgca cctggtaatt tagacggcaa     3600

agatatcgat ttagtctctg tctttgaagg tgtcggccat tggaaccacg gcgatatgac     3660

caaagaagaa gttaaagctt tggaatgtaa tgcttgtccc ggtcctggag gctgcggtgg     3720

tatgtatact gctaacacaa tggcgacagc tattgaagtt ttgggactta gccttccggg     3780

ttcatcttct cacccggctg aatccgcaga aaagaaagca gatattgaag aagctggtcg     3840

cgctgttgtc aaaatgctcg aaatgggctt aaaaccttct gacattttaa cgcgtgaagc     3900

ttttgaagat gctattactg taactatggc tctgggaggt tcaaccaact caacccttca     3960

cctcttagct attgcccatg ctgctaatgt ggaattgaca cttgatgatt tcaatacttt     4020

ccaagaaaaa gttcctcatt tggctgattt gaaaccttct ggtcaatatg tattccaaga     4080

cctttacaag gtcggagggg taccagcagt tatgaaatat ctccttaaaa atggcttcct     4140

tcatggtgac cgtatcactt gtactggcaa aacagtcgct gaaaatttga aggcttttga     4200

tgatttaaca cctggtcaaa aggttattat gccgcttgaa aatcctaaac gtgaagatgg     4260

tccgctcatt attctccatg gtaacttggc tccagacggt gccgttgcca aagtttctgg     4320

tgtaaaagtg cgtcgtcatg tcggtcctgc taaggtcttt aattctgaag aagaagccat     4380

tgaagctgtc ttgaatgatg atattgttga tggtgatgtt gttgtcgtac gttttgtagg     4440

accaaagggc ggtcctggta tgcctgaaat gctttccctt tcatcaatga ttgttggtaa     4500

agggcaaggt gaaaaagttg cccttctgac agatggccgc ttctcaggtg gtacttatgg     4560

tcttgtcgtg ggtcatatcg ctcctgaagc acaagatggc ggtccaatcg cctacctgca     4620

aacaggagac atagtcacta ttgaccaaga cactaaggaa ttacactttg atatctccga     4680

tgaagagtta aaacatcgtc aagagaccat tgaattgcca ccgctctatt cacgcggtat     4740

ccttggtaaa tatgctcaca tcgtttcgtc tgcttctagg ggagccgtaa cagacttttg     4800

gaagcctgaa gaaactggca aaaaatgttg tcctggttgc tgtggttaag cggccgcgtt     4860

aattcaaatt aattgatata gttttttaat gagtattgaa tctgtttaga aataatggaa     4920

tattattttt atttatttat ttatattatt ggtcggctct tttcttctga aggtcaatga     4980

caaaatgata tgaaggaaat aatgatttct aaaattttac aacgtaagat atttttacaa     5040

aagcctagct catcttttgt catgcactat tttactcacg cttgaaatta acggccagtc     5100

cactgcggag tcatttcaaa gtcatcctaa tcgatctatc gtttttgata gctcattttg     5160

gagttcgcga ttgtcttctg ttattcacaa ctgttttaat ttttatttca ttctggaact     5220

cttcgagttc tttgtaaagt ctttcatagt agcttacttt atcctccaac atatttaact     5280

tcatgtcaat ttcggctctt aaattttcca catcatcaag ttcaacatca tcttttaact     5340

tgaatttatt ctctagctct tccaaccaag cctcattgct ccttgattta ctggtgaaaa     5400

gtgatacact ttgcgcgcaa tccaggtcaa aactttcctg caaagaattc accaatttct     5460

cgacatcata gtacaatttg ttttgttctc ccatcacaat ttaatatacc tgatggattc     5520

ttatgaagcg ctgggtaatg gacgtgtcac tctacttcgc ctttttccct actcctttta     5580

gtacggaaga caatgctaat aaataagagg gtaataataa tattattaat cggcaaaaaa     5640

gattaaacgc caagcgttta attatcagaa agcaaacgtc gtaccaatcc ttgaatgctt     5700

cccaattgta tattaagagt catcacagca acatattctt gttattaaat taattattat     5760

tgatttttga tattgtataa aaaaaccaaa tatgtataaa aaaagtgaat aaaaaatacc     5820

aagtatggag aaatatatta gaagtctata cgttaaacca cccgggcccc ccctcgaggt     5880

cgacggtatc gataagcttg atatcgaatt cctgcagccc gggggatcca ctagttctag     5940

agcggccgct ctagaactag taccacaggt gttgtcctct gaggacataa aatacacacc     6000

gagattcatc aactcattgc tggagttagc atatctacaa ttgggtgaaa tggggagcga     6060

tttgcaggca tttgctcggc atgccggtag aggtgtggtc aataagagcg acctcatgct     6120

atacctgaga aagcaacctg acctacagga aagagttact caagaataag aattttcgtt     6180

ttaaaaccta agagtcactt taaaatttgt atacacttat tttttttata acttatttaa     6240

taataaaaat cataaatcat aagaaattcg cttactctta attaatcaaa aagttaaaat     6300

tgtacgaata gattcaccac ttcttaacaa atcaaaccct tcattgattt tctcgaatgg     6360

caatacatgt gtaattaaag gatcaagagc aaacttcttc gccataaagt cggcaacaag     6420

ttttggaaca ctatccttgc tcttaaaacc gccaaatata gctcccttcc atgtacgacc     6480

gcttagcaac agcataggat tcatcgacaa attttgtgaa tcaggaggaa cacctacgat     6540

cacactgact ccatatgcct cttgacagca ggacaacgca gttaccatag tatcaagacg     6600

gcctataact tcaaaagaga aatcaactcc accgtttgac atttcagtaa ggacttcttg     6660

tattggtttc ttataatctt gagggttaac acattcagta gccccgacct ccttagcttt     6720

tgcaaatttg tccttattga tgtctacacc tataatcctc gctgcgcctg cagctttaca     6780

ccccataata acgcttagtc ctactcctcc taaaccgaat actgcacaag tcgaaccctg     6840

tgtaaccttt gcaactttaa ctgcggaacc gtaaccggtg gaaaatccgc accctatcaa     6900

gcaaactttt tccagtggtg aagctgcatc gattttagcg acagatatct cgtccaccac     6960

tgtgtattgg gaaaatgtag aagtaccaag gaaatggtgt ataggtttcc ctctgcatgt     7020

aaatctgctt gtaccatcct gcatagtacc tctaggcata gacaaatcat ttttaaggca     7080

gaaattaccc tcaggatgtt tgcagactct acacttacca cattgaggag tgaacagtgg     7140

gatcacttta tcaccaggac gaacagtggt aacaccttca cctatggatt caacgattcc     7200

ggcagcctcg tgtcccgcga ttactggcaa aggagtaact agagtgccac tcaccacatg     7260

gtcgtcggat ctacagattc cggtggcaac catcttgatt ctaacctcgt gtgcttttgg     7320

tggcgctact tctacttctt ctatgctaaa cggctttttc tcttcccaca aaactgccgc     7380

tttacactta ataactttac cggctgttga catcctcagc tagctattgt aatatgtgtg     7440

tttgtttgga ttattaagaa gaataattac aaaaaaaatt acaaaggaag gtaattacaa     7500

cagaattaag aaaggacaag aaggaggaag agaatcagtt cattatttct tctttgttat     7560

ataacaaacc caagtagcga tttggccata cattaaaagt tgagaaccac cctccctggc     7620

aacagccaca actcgttacc attgttcatc acgatcatga aactcgctgt cagctgaaat     7680

ttcacctcag tggatctctc tttttattct tcatcgttcc actaaccttt ttccatcagc     7740

tggcagggaa cggaaagtgg aatcccattt agcgagcttc ctcttttctt caagaaaaga     7800

cgaagcttgt gtgtgggtgc gcgcgctagt atctttccac attaagaaat ataccataaa     7860

ggttacttag acatcactat ggctatatat atatatatat atatatgtaa cttagcacca     7920

tcgcgcgtgc atcactgcat gtgttaaccg aaaagtttgg cgaacacttc accgacacgg     7980

tcatttagat ctgtcgtctg cattgcacgt cccttagcct taaatcctag gcgggagcat     8040

tctcgtgtaa ttgtgcagcc tgcgtagcaa ctcaacatag cgtagtctac ccagtttttc     8100

aagggtttat cgttagaaga ttctcccttt tcttcctgct cacaaatctt aaagtcatac     8160

attgcacgac taaatgcaag catgcggatc ccccgggctg caggaattcg atatcaagct     8220

tatcgatacc gtcgactggc cattaatctt tcccatatta gatttcgcca agccatgaaa     8280

gttcaagaaa ggtctttaga cgaattaccc ttcatttctc aaactggcgt caagggatcc     8340

tggtatggtt ttatcgtttt atttctggtt cttatagcat cgttttggac ttctctgttc     8400

ccattaggcg gttcaggagc cagcgcagaa tcattctttg aaggatactt atcctttcca     8460

attttgattg tctgttacgt tggacataaa ctgtatacta gaaattggac tttgatggtg     8520

aaactagaag atatggatct tgataccggc agaaaacaag tagatttgac tcttcgtagg     8580

gaagaaatga ggattgagcg agaaacatta gcaaaaagat ccttcgtaac aagattttta     8640

catttctggt gttgaaggga aagatatgag ctatacagcg gaatttccat atcactcaga     8700

ttttgttatc taattttttc cttcccacgt ccgcgggaat ctgtgtatat tactgcatct     8760

agatatatgt tatcttatct tggcgcgtac atttaatttt caacgtattc tataagaaat     8820

tgcgggagtt tttttcatgt agatgatact gactgcacgc aaatataggc atgatttata     8880

ggcatgattt gatggctgta ccgataggaa cgctaagagt aacttcagaa tcgttatcct     8940

ggcggaaaaa attcatttgt aaactttaaa aaaaaaagcc aatatcccca aaattattaa     9000

gagcgcctcc attattaact aaaatttcac tcagcatcca caatgtatca ggtatctact     9060

acagatatta catgtggcga aaaagacaag aacaatgcaa tagcgcatca agaaaaaaca     9120

caaagctttc aatcaatgaa tcgaaaatgt cattaaaata gtatataaat tgaaactaag     9180

tcataaagct ataaaaagaa aatttattta aatgcaagat ttaaagtaaa ttcacggccc     9240

tgcaggcctc agctcttgtt ttgttctgca aataacttac ccatcttttt caaaacttta     9300

ggtgcaccct cctttgctag aataagttct atccaataca tcctatttgg atctgcttga     9360

gcttctttca tcacggatac gaattcattt tctgttctca caattttgga cacaactctg     9420

tcttccgttg ccccgaaact ttctggcagt tttgagtaat tccacatagg aatgtcatta     9480

taactctggt tcggaccatg aatttccctc tcaaccgtgt aaccatcgtt attaatgata     9540

aagcagattg ggtttatctt ctctctaatg gctagtccta attcttggac agtcagttgc     9600

aatgatccat ctccgataaa caataaatgt ctagattctt tatctgcaat ttggctgcct     9660

agagctgcgg ggaaagtgta tcctatagat ccccacaagg gttgaccaat aaaatgtgat     9720

ttcgatttca gaaatataga tgaggcaccg aagaaagaag tgccttgttc agccacgatc     9780

gtctcattac tttgggtcaa attttcgaca gcttgccaca gtctatcttg tgacaacagc     9840

gcgttagaag gtacaaaatc ttcttgcttt ttatctatgt acttgccttt atattcaatt     9900

tcggacaagt caagaagaga tgatatcagg gattcgaagt cgaaattttg gattctttcg     9960

ttgaaaattt taccttcatc gatattcaag gaaatcattt tattttcatt aagatggtga    10020

gtaaatgcac ccgtactaga atcggtaagc tttacaccca acataagaat aaaatcagca    10080

gattccacaa attccttcaa gtttggctct gacagagtac cgttgtaaat ccccaaaaat    10140

gagggcaatg cttcatcaac agatgattta ccaaagttca aagtagtaat aggtaactta    10200

gtctttgaaa taaactgagt aacagtcttc tctaggccga acgatataat ttcatggcct    10260

gtgattacaa ttggtttctt ggcattcttc agactttcct gtattttgtt cagaatctct    10320

tgatcagatg tattcgacgt ggaattttcc ttcttaagag gcaaggatgg tttttcagcc    10380

ttagcggcag ctacatctac aggtaaattg atgtaaaccg gctttctttc ctttagtaag    10440

gcagacaaca ctctatcaat ttcaacagtt gcattctcgg ctgtcaataa agtcctggca    10500

gcagtaaccg gttcgtgcat cttcataaag tgcttgaaat caccatcagc caacgtatgg    10560

tgaacaaact taccttcgtt ctgcactttc gaggtaggag atcccacgat ctcaacaaca    10620

ggcaggttct cagcatagga gcccgctaag ccattaactg cggataattc gccaacacca    10680

aatgtagtca agaatgccgc agcctttttc gttcttgcgt acccgtcggc catataggag    10740

gcatttaact cattagcatt tcccacccat ttcatatctt tgtgtgaaat aatttgatct    10800

agaaattgca aattgtagtc acctggtact ccgaatattt cttctatacc taattcgtgt    10860

aatctgtcca acagatagtc acctactgta tacattttgt ttactagttt atgtgtgttt    10920

attcgaaact aagttcttgg tgttttaaaa ctaaaaaaaa gactaactat aaaagtagaa    10980

tttaagaagt ttaagaaata gatttacaga attacaatca atacctaccg tctttatata    11040

cttattagtc aagtagggga ataatttcag ggaactggtt tcaacctttt ttttcagctt    11100

tttccaaatc agagagagca gaaggtaata gaaggtgtaa gaaaatgaga tagatacatg    11160

cgtgggtcaa ttgccttgtg tcatcattta ctccaggcag gttgcatcac tccattgagg    11220

ttgtgcccgt tttttgcctg tttgtgcccc tgttctctgt agttgcgcta agagaatgga    11280

cctatgaact gatggttggt gaagaaaaca atattttggt gctgggattc tttttttttc    11340

tggatgccag cttaaaaagc gggctccatt atatttagtg gatgccagga ataaactgtt    11400

cacccagaca cctacgatgt tatatattct gtgtaacccg ccccctattt tgggcatgta    11460

cgggttacag cagaattaaa aggctaattt tttgactaaa taaagttagg aaaatcacta    11520

ctattaatta tttacgtatt ctttgaaatg gcagtattga taatgataaa ctcgaactga    11580

aaaagcgtgt tttttattca aaatgattct aactccctta cgtaatcaag gaatcttttt    11640

gccttggcct ccgcgtcatt aaacttcttg ttgttgacgc taacattcaa cgctagtata    11700

tattcgtttt tttcaggtaa gttcttttca acgggtctta ctgatgaggc agtcgcgtct    11760

gaacctgtta agaggtcaaa tatgtcttct tgaccgtacg tgtcttgcat gttattagct    11820

ttgggaattt gcatcaagtc ataggaaaat ttaaatcttg gctctcttgg gctcaaggtg    11880

acaaggtcct cgaaaatagg gcgcgcccca ccgcggtgga gctccagctt ttgttccctt    11940

tagtgagggt taattgcgcg cttggcgtaa tcatggtcat agctgtttcc tgtgtgaaat    12000

tgttatccgc tcacaattcc acacaacata cgagccggaa gcataaagtg taaagcctgg    12060

ggtgcctaat gagtgagcta actcacatta attgcgttgc gctcactgcc cgctttccag    12120

tcgggaaacc tgtcgtgcca gctgcattaa tgaatcggcc aacgcgcggg gagaggcggt    12180

ttgcgtattg ggcgctcttc cgcttcctcg ctcactgact cgctgcgctc ggtcgttcgg    12240

ctgcggcgag cggtatcagc tcactcaaag gcggtaatac ggttatccac agaatcaggg    12300

gataacgcag gaaagaacat gtgagcaaaa ggccagcaaa aggccaggaa ccgtaaaaag    12360

gccgcgttgc tggcgttttt ccataggctc cgcccccctg acgagcatca caaaaatcga    12420

cgctcaagtc agaggtggcg aaacccgaca ggactataaa gataccaggc gtttccccct    12480

ggaagctccc tcgtgcgctc tcctgttccg accctgccgc ttaccggata cctgtccgcc    12540

tttctccctt cgggaagcgt ggcgctttct catagctcac gctgtaggta tctcagttcg    12600

gtgtaggtcg ttcgctccaa gctgggctgt gtgcacgaac cccccgttca gcccgaccgc    12660

tgcgccttat ccggtaacta tcgtcttgag tccaacccgg taagacacga cttatcgcca    12720

ctggcagcag ccactggtaa caggattagc agagcgaggt atgtaggcgg tgctacagag    12780

ttcttgaagt ggtggcctaa ctacggctac actagaagaa cagtatttgg tatctgcgct    12840

ctgctgaagc cagttacctt cggaaaaaga gttggtagct cttgatccgg caaacaaacc    12900

accgctggta gcggtggttt ttttgtttgc aagcagcaga ttacgcgcag aaaaaaagga    12960

tctcaagaag atcctttgat cttttctacg gggtctgacg ctcagtggaa cgaaaactca    13020

cgttaaggga ttttggtcat gagattatca aaaaggatct tcacctagat ccttttaaat    13080

taaaaatgaa gttttaaatc aatctaaagt atatatgagt aaacttggtc tgacagttac    13140

caatgcttaa tcagtgaggc acctatctca gcgatctgtc tatttcgttc atccatagtt    13200

gcctgactcc ccgtcgtgta gataactacg atacgggagg gcttaccatc tggccccagt    13260

gctgcaatga taccgcgaga cccacgctca ccggctccag atttatcagc aataaaccag    13320

ccagccggaa gggccgagcg cagaagtggt cctgcaactt tatccgcctc catccagtct    13380

attaattgtt gccgggaagc tagagtaagt agttcgccag ttaatagttt gcgcaacgtt    13440

gttgccattg ctacaggcat cgtggtgtca cgctcgtcgt ttggtatggc ttcattcagc    13500

tccggttccc aacgatcaag gcgagttaca tgatccccca tgttgtgcaa aaaagcggtt    13560

agctccttcg gtcctccgat cgttgtcaga agtaagttgg ccgcagtgtt atcactcatg    13620

gttatggcag cactgcataa ttctcttact gtcatgccat ccgtaagatg cttttctgtg    13680

actggtgagt actcaaccaa gtcattctga gaatagtgta tgcggcgacc gagttgctct    13740

tgcccggcgt caatacggga taataccgcg ccacatagca gaactttaaa agtgctcatc    13800

attggaaaac gttcttcggg gcgaaaactc tcaaggatct taccgctgtt gagatccagt    13860

tcgatgtaac ccactcgtgc acccaactga tcttcagcat cttttacttt caccagcgtt    13920

tctgggtgag caaaaacagg aaggcaaaat gccgcaaaaa agggaataag ggcgacacgg    13980

aaatgttgaa tactcatact cttccttttt caatattatt gaagcattta tcagggttat    14040

tgtctcatga gcggatacat atttgaatgt atttagaaaa ataaacaaat aggggttccg    14100

cgcacatttc cccgaaaagt gccacctgaa cgaagcatct gtgcttcatt ttgtagaaca    14160

aaaatgcaac gcgagagcgc taatttttca aacaaagaat ctgagctgca tttttacaga    14220

acagaaatgc aacgcgaaag cgctatttta ccaacgaaga atctgtgctt catttttgta    14280

aaacaaaaat gcaacgcgag agcgctaatt tttcaaacaa agaatctgag ctgcattttt    14340

acagaacaga aatgcaacgc gagagcgcta ttttaccaac aaagaatcta tacttctttt    14400

ttgttctaca aaaatgcatc ccgagagcgc tatttttcta acaaagcatc ttagattact    14460

ttttttctcc tttgtgcgct ctataatgca gtctcttgat aactttttgc actgtaggtc    14520

cgttaaggtt agaagaaggc tactttggtg tctattttct cttccataaa aaaagcctga    14580

ctccacttcc cgcgtttact gattactagc gaagctgcgg gtgcattttt tcaagataaa    14640

ggcatccccg attatattct ataccgatgt ggattgcgca tactttgtga acagaaagtg    14700

atagcgttga tgattcttca ttggtcagaa aattatgaac ggtttcttct attttgtctc    14760

tatatactac gtataggaaa tgtttacatt ttcgtattgt tttcgattca ctctatgaat    14820

agttcttact acaatttttt tgtctaaaga gtaatactag agataaacat aaaaaatgta    14880

gaggtcgagt ttagatgcaa gttcaaggag cgaaaggtgg atgggtaggt tatataggga    14940

tatagcacag agatatatag caaagagata cttttgagca atgtttgtgg aagcggtatt    15000

cgcaatattt tagtagctcg ttacagtccg gtgcgttttt ggttttttga aagtgcgtct    15060

tcagagcgct tttggttttc aaaagcgctc tgaagttcct atactttcta gagaatagga    15120

acttcggaat aggaacttca aagcgtttcc gaaaacgagc gcttccgaaa atgcaacgcg    15180

agctgcgcac atacagctca ctgttcacgt cgcacctata tctgcgtgtt gcctgtatat    15240

atatatacat gagaagaacg gcatagtgcg tgtttatgct taaatgcgta cttatatgcg    15300

tctatttatg taggatgaaa ggtagtctag tacctcctgt gatattatcc cattccatgc    15360

ggggtatcgt atgcttcctt cagcactacc ctttagctgt tctatatgct gccactcctc    15420

aattggatta gtctcatcct tcaatgctat catttccttt gatattggat catactaaga    15480

aaccattatt atcatgacat taacctataa aaataggcgt atcacgaggc cctttcgtc     15539


<210>  56
<211>  1125
<212>  DNA
<213>  artificial sequence

<220>
<223>  horse ADH coding region codon optimized for S. cerevisiae 
       expression

<400>  56
atgtcaacag ccggtaaagt tattaagtgt aaagcggcag ttttgtggga agagaaaaag       60

ccgtttagca tagaagaagt agaagtagcg ccaccaaaag cacacgaggt tagaatcaag      120

atggttgcca ccggaatctg tagatccgac gaccatgtgg tgagtggcac tctagttact      180

cctttgccag taatcgcggg acacgaggct gccggaatcg ttgaatccat aggtgaaggt      240

gttaccactg ttcgtcctgg tgataaagtg atcccactgt tcactcctca atgtggtaag      300

tgtagagtct gcaaacatcc tgagggtaat ttctgcctta aaaatgattt gtctatgcct      360

agaggtacta tgcaggatgg tacaagcaga tttacatgca gagggaaacc tatacaccat      420

ttccttggta cttctacatt ttcccaatac acagtggtgg acgagatatc tgtcgctaaa      480

atcgatgcag cttcaccact ggaaaaagtt tgcttgatag ggtgcggatt ttccaccggt      540

tacggttccg cagttaaagt tgcaaaggtt acacagggtt cgacttgtgc agtattcggt      600

ttaggaggag taggactaag cgttattatg gggtgtaaag ctgcaggcgc agcgaggatt      660

ataggtgtag acatcaataa ggacaaattt gcaaaagcta aggaggtcgg ggctactgaa      720

tgtgttaacc ctcaagatta taagaaacca atacaagaag tccttactga aatgtcaaac      780

ggtggagttg atttctcttt tgaagttata ggccgtcttg atactatggt aactgcgttg      840

tcctgctgtc aagaggcata tggagtcagt gtgatcgtag gtgttcctcc tgattcacaa      900

aatttgtcga tgaatcctat gctgttgcta agcggtcgta catggaaggg agctatattt      960

ggcggtttta agagcaagga tagtgttcca aaacttgttg ccgactttat ggcgaagaag     1020

tttgctcttg atcctttaat tacacatgta ttgccattcg agaaaatcaa tgaagggttt     1080

gatttgttaa gaagtggtga atctattcgt acaattttaa ctttt                     1125


<210>  57
<211>  375
<212>  PRT
<213>  Equus caballus

<400>  57

Met Ser Thr Ala Gly Lys Val Ile Lys Cys Lys Ala Ala Val Leu Trp 
1               5                   10                  15      


Glu Glu Lys Lys Pro Phe Ser Ile Glu Glu Val Glu Val Ala Pro Pro 
            20                  25                  30          


Lys Ala His Glu Val Arg Ile Lys Met Val Ala Thr Gly Ile Cys Arg 
        35                  40                  45              


Ser Asp Asp His Val Val Ser Gly Thr Leu Val Thr Pro Leu Pro Val 
    50                  55                  60                  


Ile Ala Gly His Glu Ala Ala Gly Ile Val Glu Ser Ile Gly Glu Gly 
65                  70                  75                  80  


Val Thr Thr Val Arg Pro Gly Asp Lys Val Ile Pro Leu Phe Thr Pro 
                85                  90                  95      


Gln Cys Gly Lys Cys Arg Val Cys Lys His Pro Glu Gly Asn Phe Cys 
            100                 105                 110         


Leu Lys Asn Asp Leu Ser Met Pro Arg Gly Thr Met Gln Asp Gly Thr 
        115                 120                 125             


Ser Arg Phe Thr Cys Arg Gly Lys Pro Ile His His Phe Leu Gly Thr 
    130                 135                 140                 


Ser Thr Phe Ser Gln Tyr Thr Val Val Asp Glu Ile Ser Val Ala Lys 
145                 150                 155                 160 


Ile Asp Ala Ala Ser Pro Leu Glu Lys Val Cys Leu Ile Gly Cys Gly 
                165                 170                 175     


Phe Ser Thr Gly Tyr Gly Ser Ala Val Lys Val Ala Lys Val Thr Gln 
            180                 185                 190         


Gly Ser Thr Cys Ala Val Phe Gly Leu Gly Gly Val Gly Leu Ser Val 
        195                 200                 205             


Ile Met Gly Cys Lys Ala Ala Gly Ala Ala Arg Ile Ile Gly Val Asp 
    210                 215                 220                 


Ile Asn Lys Asp Lys Phe Ala Lys Ala Lys Glu Val Gly Ala Thr Glu 
225                 230                 235                 240 


Cys Val Asn Pro Gln Asp Tyr Lys Lys Pro Ile Gln Glu Val Leu Thr 
                245                 250                 255     


Glu Met Ser Asn Gly Gly Val Asp Phe Ser Phe Glu Val Ile Gly Arg 
            260                 265                 270         


Leu Asp Thr Met Val Thr Ala Leu Ser Cys Cys Gln Glu Ala Tyr Gly 
        275                 280                 285             


Val Ser Val Ile Val Gly Val Pro Pro Asp Ser Gln Asn Leu Ser Met 
    290                 295                 300                 


Asn Pro Met Leu Leu Leu Ser Gly Arg Thr Trp Lys Gly Ala Ile Phe 
305                 310                 315                 320 


Gly Gly Phe Lys Ser Lys Asp Ser Val Pro Lys Leu Val Ala Asp Phe 
                325                 330                 335     


Met Ala Lys Lys Phe Ala Leu Asp Pro Leu Ile Thr His Val Leu Pro 
            340                 345                 350         


Phe Glu Lys Ile Asn Glu Gly Phe Asp Leu Leu Arg Ser Gly Glu Ser 
        355                 360                 365             


Ile Arg Thr Ile Leu Thr Phe 
    370                 375 


<210>  58
<211>  9089
<212>  DNA
<213>  artificial sequence

<220>
<223>  constructed plasmid

<400>  58
tcgcgcgttt cggtgatgac ggtgaaaacc tctgacacat gcagctcccg gagacggtca       60

cagcttgtct gtaagcggat gccgggagca gacaagcccg tcagggcgcg tcagcgggtg      120

ttggcgggtg tcggggctgg cttaactatg cggcatcaga gcagattgta ctgagagtgc      180

accataccac agcttttcaa ttcaattcat catttttttt ttattctttt ttttgatttc      240

ggtttctttg aaattttttt gattcggtaa tctccgaaca gaaggaagaa cgaaggaagg      300

agcacagact tagattggta tatatacgca tatgtagtgt tgaagaaaca tgaaattgcc      360

cagtattctt aacccaactg cacagaacaa aaacctgcag gaaacgaaga taaatcatgt      420

cgaaagctac atataaggaa cgtgctgcta ctcatcctag tcctgttgct gccaagctat      480

ttaatatcat gcacgaaaag caaacaaact tgtgtgcttc attggatgtt cgtaccacca      540

aggaattact ggagttagtt gaagcattag gtcccaaaat ttgtttacta aaaacacatg      600

tggatatctt gactgatttt tccatggagg gcacagttaa gccgctaaag gcattatccg      660

ccaagtacaa ttttttactc ttcgaagaca gaaaatttgc tgacattggt aatacagtca      720

aattgcagta ctctgcgggt gtatacagaa tagcagaatg ggcagacatt acgaatgcac      780

acggtgtggt gggcccaggt attgttagcg gtttgaagca ggcggcagaa gaagtaacaa      840

aggaacctag aggccttttg atgttagcag aattgtcatg caagggctcc ctatctactg      900

gagaatatac taagggtact gttgacattg cgaagagcga caaagatttt gttatcggct      960

ttattgctca aagagacatg ggtggaagag atgaaggtta cgattggttg attatgacac     1020

ccggtgtggg tttagatgac aagggagacg cattgggtca acagtataga accgtggatg     1080

atgtggtctc tacaggatct gacattatta ttgttggaag aggactattt gcaaagggaa     1140

gggatgctaa ggtagagggt gaacgttaca gaaaagcagg ctgggaagca tatttgagaa     1200

gatgcggcca gcaaaactaa aaaactgtat tataagtaaa tgcatgtata ctaaactcac     1260

aaattagagc ttcaatttaa ttatatcagt tattacccta tgcggtgtga aataccgcac     1320

agatgcgtaa ggagaaaata ccgcatcagg aaattgtaaa cgttaatatt ttgttaaaat     1380

tcgcgttaaa tttttgttaa atcagctcat tttttaacca ataggccgaa atcggcaaaa     1440

tcccttataa atcaaaagaa tagaccgaga tagggttgag tgttgttcca gtttggaaca     1500

agagtccact attaaagaac gtggactcca acgtcaaagg gcgaaaaacc gtctatcagg     1560

gcgatggccc actacgtgaa ccatcaccct aatcaagttt tttggggtcg aggtgccgta     1620

aagcactaaa tcggaaccct aaagggagcc cccgatttag agcttgacgg ggaaagccgg     1680

cgaacgtggc gagaaaggaa gggaagaaag cgaaaggagc gggcgctagg gcgctggcaa     1740

gtgtagcggt cacgctgcgc gtaaccacca cacccgccgc gcttaatgcg ccgctacagg     1800

gcgcgtcgcg ccattcgcca ttcaggctgc gcaactgttg ggaagggcga tcggtgcggg     1860

cctcttcgct attacgccag ctggcgaaag ggggatgtgc tgcaaggcga ttaagttggg     1920

taacgccagg gttttcccag tcacgacgtt gtaaaacgac ggccagtgag cgcgcgtaat     1980

acgactcact atagggcgaa ttgggtaccg ggccccccct cgaggtcgac tggccattaa     2040

tctttcccat attagatttc gccaagccat gaaagttcaa gaaaggtctt tagacgaatt     2100

acccttcatt tctcaaactg gcgtcaaggg atcctggtat ggttttatcg ttttatttct     2160

ggttcttata gcatcgtttt ggacttctct gttcccatta ggcggttcag gagccagcgc     2220

agaatcattc tttgaaggat acttatcctt tccaattttg attgtctgtt acgttggaca     2280

taaactgtat actagaaatt ggactttgat ggtgaaacta gaagatatgg atcttgatac     2340

cggcagaaaa caagtagatt tgactcttcg tagggaagaa atgaggattg agcgagaaac     2400

attagcaaaa agatccttcg taacaagatt tttacatttc tggtgttgaa gggaaagata     2460

tgagctatac agcggaattt ccatatcact cagattttgt tatctaattt tttccttccc     2520

acgtccgcgg gaatctgtgt atattactgc atctagatat atgttatctt atcttggcgc     2580

gtacatttaa ttttcaacgt attctataag aaattgcggg agtttttttc atgtagatga     2640

tactgactgc acgcaaatat aggcatgatt tataggcatg atttgatggc tgtaccgata     2700

ggaacgctaa gagtaacttc agaatcgtta tcctggcgga aaaaattcat ttgtaaactt     2760

taaaaaaaaa agccaatatc cccaaaatta ttaagagcgc ctccattatt aactaaaatt     2820

tcactcagca tccacaatgt atcaggtatc tactacagat attacatgtg gcgaaaaaga     2880

caagaacaat gcaatagcgc atcaagaaaa aacacaaagc tttcaatcaa tgaatcgaaa     2940

atgtcattaa aatagtatat aaattgaaac taagtcataa agctataaaa agaaaattta     3000

tttaaatgca agatttaaag taaattcacg gccctgcagg ccctaacctg ctaggacaca     3060

acgtctttgc ctggtaaagt ttctagctga cgtgattcct tcacctgtgg atccggcaat     3120

tgtaaaggtt gtgaaaccct cagcttcata accgacacct gcaaatgact ttgcattctt     3180

aacaaagata gttgtatcaa tttcacgttc gaatctatta aggttatcga tgttcttaga     3240

ataaatgtag gcggaatgtt ttctattctg ctcagctatc ttggcgtatt taatggcttc     3300

atcaatgtcc ttcactctaa ctataggcaa aattggcatc atcaactccg tcataacgaa     3360

cggatggttt gcgttgactt cacaaataat acactttaca ttacttggtg actctacatc     3420

tatttcatcc aaaaacagtt tagcgtcctt accaacccac ttcttattaa tgaaatattc     3480

ttgagtttca ttgttctttt gaagaacaag gtctatcagc ttggatactt ggtcttcatt     3540

gataatgacg gcgttgtttt tcaacatgtt agagatcaga tcatctgcaa cgttttcaaa     3600

cacgaacact tctttttccg cgatacaagg aagattgttg tcaaacgaac aaccttcaat     3660

aatgcttctg ccggccttct cgatatctgc tgtatcgtct acaataaccg gaggattacc     3720

cgcgccagct ccgatggcct ttttaccaga attaagaagg gtttttacca tacccgggcc     3780

acccgtaccg cacaacaatt ttatggatgg atgtttgata atagcgtcta aactttccat     3840

agttgggttc tttatagtag tgacaaggtt ttcaggtcca ccacagctaa ttatggcttt     3900

gtttatcatt tctactgcga aagcgacaca ctttttggcg catgggtgac cattaaatac     3960

aactgcattc cccgcagcta tcatacctat agaattgcag ataacggttt ctgttggatt     4020

cgtgcttgga gttatagcgc cgataactcc gtatggactc atttcaacca ctgttagtcc     4080

attatcgccg gaccatgctg ttgttgtcag atcttcagtg cctggggtat acttggccac     4140

taattcatgt ttcaagattt tatcctcata ccttcccatg tgggtttcct ccaggatcat     4200

tgtggctaag acctctttat tctgtaatgc ggcttttctt atttcggtga ttattttctc     4260

tctttgttcc tttgtgtagt gtagggaaag aatcttttgt gcatgtactg cagaagaaat     4320

ggcattctca acattttcaa atactccaaa acatgaagag ttatctttgt aattctttaa     4380

gttgatgttt tcaccattag tcttcacttt caagtctttg gtggttggga ttaaggtatc     4440

tttatccatg gtgtttgttt atgtgtgttt attcgaaact aagttcttgg tgttttaaaa     4500

ctaaaaaaaa gactaactat aaaagtagaa tttaagaagt ttaagaaata gatttacaga     4560

attacaatca atacctaccg tctttatata cttattagtc aagtagggga ataatttcag     4620

ggaactggtt tcaacctttt ttttcagctt tttccaaatc agagagagca gaaggtaata     4680

gaaggtgtaa gaaaatgaga tagatacatg cgtgggtcaa ttgccttgtg tcatcattta     4740

ctccaggcag gttgcatcac tccattgagg ttgtgcccgt tttttgcctg tttgtgcccc     4800

tgttctctgt agttgcgcta agagaatgga cctatgaact gatggttggt gaagaaaaca     4860

atattttggt gctgggattc tttttttttc tggatgccag cttaaaaagc gggctccatt     4920

atatttagtg gatgccagga ataaactgtt cacccagaca cctacgatgt tatatattct     4980

gtgtaacccg ccccctattt tgggcatgta cgggttacag cagaattaaa aggctaattt     5040

tttgactaaa taaagttagg aaaatcacta ctattaatta tttacgtatt ctttgaaatg     5100

gcagtattga taatgataaa ctcgaactga aaaagcgtgt tttttattca aaatgattct     5160

aactccctta cgtaatcaag gaatcttttt gccttggcct ccgcgtcatt aaacttcttg     5220

ttgttgacgc taacattcaa cgctagtata tattcgtttt tttcaggtaa gttcttttca     5280

acgggtctta ctgatgaggc agtcgcgtct gaacctgtta agaggtcaaa tatgtcttct     5340

tgaccgtacg tgtcttgcat gttattagct ttgggaattt gcatcaagtc ataggaaaat     5400

ttaaatcttg gctctcttgg gctcaaggtg acaaggtcct cgaaaatagg gcgcgcccca     5460

ccgcggtgga gctccagctt ttgttccctt tagtgagggt taattgcgcg cttggcgtaa     5520

tcatggtcat agctgtttcc tgtgtgaaat tgttatccgc tcacaattcc acacaacata     5580

ggagccggaa gcataaagtg taaagcctgg ggtgcctaat gagtgaggta actcacatta     5640

attgcgttgc gctcactgcc cgctttccag tcgggaaacc tgtcgtgcca gctgcattaa     5700

tgaatcggcc aacgcgcggg gagaggcggt ttgcgtattg ggcgctcttc cgcttcctcg     5760

ctcactgact cgctgcgctc ggtcgttcgg ctgcggcgag cggtatcagc tcactcaaag     5820

gcggtaatac ggttatccac agaatcaggg gataacgcag gaaagaacat gtgagcaaaa     5880

ggccagcaaa aggccaggaa ccgtaaaaag gccgcgttgc tggcgttttt ccataggctc     5940

cgcccccctg acgagcatca caaaaatcga cgctcaagtc agaggtggcg aaacccgaca     6000

ggactataaa gataccaggc gtttccccct ggaagctccc tcgtgcgctc tcctgttccg     6060

accctgccgc ttaccggata cctgtccgcc tttctccctt cgggaagcgt ggcgctttct     6120

catagctcac gctgtaggta tctcagttcg gtgtaggtcg ttcgctccaa gctgggctgt     6180

gtgcacgaac cccccgttca gcccgaccgc tgcgccttat ccggtaacta tcgtcttgag     6240

tccaacccgg taagacacga cttatcgcca ctggcagcag ccactggtaa caggattagc     6300

agagcgaggt atgtaggcgg tgctacagag ttcttgaagt ggtggcctaa ctacggctac     6360

actagaagga cagtatttgg tatctgcgct ctgctgaagc cagttacctt cggaaaaaga     6420

gttggtagct cttgatccgg caaacaaacc accgctggta gcggtggttt ttttgtttgc     6480

aagcagcaga ttacgcgcag aaaaaaagga tctcaagaag atcctttgat cttttctacg     6540

gggtctgacg ctcagtggaa cgaaaactca cgttaaggga ttttggtcat gagattatca     6600

aaaaggatct tcacctagat ccttttaaat taaaaatgaa gttttaaatc aatctaaagt     6660

atatatgagt aaacttggtc tgacagttac caatgcttaa tcagtgaggc acctatctca     6720

gcgatctgtc tatttcgttc atccatagtt gcctgactcc ccgtcgtgta gataactacg     6780

atacgggagg gcttaccatc tggccccagt gctgcaatga taccgcgaga cccacgctca     6840

ccggctccag atttatcagc aataaaccag ccagccggaa gggccgagcg cagaagtggt     6900

cctgcaactt tatccgcctc catccagtct attaattgtt gccgggaagc tagagtaagt     6960

agttcgccag ttaatagttt gcgcaacgtt gttgccattg ctacaggcat cgtggtgtca     7020

cgctcgtcgt ttggtatggc ttcattcagc tccggttccc aacgatcaag gcgagttaca     7080

tgatccccca tgttgtgcaa aaaagcggtt agctccttcg gtcctccgat cgttgtcaga     7140

agtaagttgg ccgcagtgtt atcactcatg gttatggcag cactgcataa ttctcttact     7200

gtcatgccat ccgtaagatg cttttctgtg actggtgagt actcaaccaa gtcattctga     7260

gaatagtgta tgcggcgacc gagttgctct tgcccggcgt caatacggga taataccgcg     7320

ccacatagca gaactttaaa agtgctcatc attggaaaac gttcttcggg gcgaaaactc     7380

tcaaggatct taccgctgtt gagatccagt tcgatgtaac ccactcgtgc acccaactga     7440

tcttcagcat cttttacttt caccagcgtt tctgggtgag caaaaacagg aaggcaaaat     7500

gccgcaaaaa agggaataag ggcgacacgg aaatgttgaa tactcatact cttccttttt     7560

caatattatt gaagcattta tcagggttat tgtctcatga gcggatacat atttgaatgt     7620

atttagaaaa ataaacaaat aggggttccg cgcacatttc cccgaaaagt gccacctgaa     7680

cgaagcatct gtgcttcatt ttgtagaaca aaaatgcaac gcgagagcgc taatttttca     7740

aacaaagaat ctgagctgca tttttacaga acagaaatgc aacgcgaaag cgctatttta     7800

ccaacgaaga atctgtgctt catttttgta aaacaaaaat gcaacgcgag agcgctaatt     7860

tttcaaacaa agaatctgag ctgcattttt acagaacaga aatgcaacgc gagagcgcta     7920

ttttaccaac aaagaatcta tacttctttt ttgttctaca aaaatgcatc ccgagagcgc     7980

tatttttcta acaaagcatc ttagattact ttttttctcc tttgtgcgct ctataatgca     8040

gtctcttgat aactttttgc actgtaggtc cgttaaggtt agaagaaggc tactttggtg     8100

tctattttct cttccataaa aaaagcctga ctccacttcc cgcgtttact gattactagc     8160

gaagctgcgg gtgcattttt tcaagataaa ggcatccccg attatattct ataccgatgt     8220

ggattgcgca tactttgtga acagaaagtg atagcgttga tgattcttca ttggtcagaa     8280

aattatgaac ggtttcttct attttgtctc tatatactac gtataggaaa tgtttacatt     8340

ttcgtattgt tttcgattca ctctatgaat agttcttact acaatttttt tgtctaaaga     8400

gtaatactag agataaacat aaaaaatgta gaggtcgagt ttagatgcaa gttcaaggag     8460

cgaaaggtgg atgggtaggt tatataggga tatagcacag agatatatag caaagagata     8520

cttttgagca atgtttgtgg aagcggtatt cgcaatattt tagtagctcg ttacagtccg     8580

gtgcgttttt ggttttttga aagtgcgtct tcagagcgct tttggttttc aaaagcgctc     8640

tgaagttcct atactttcta gagaatagga acttcggaat aggaacttca aagcgtttcc     8700

gaaaacgagc gcttccgaaa atgcaacgcg agctgcgcac atacagctca ctgttcacgt     8760

cgcacctata tctgcgtgtt gcctgtatat atatatacat gagaagaacg gcatagtgcg     8820

tgtttatgct taaatgcgta cttatatgcg tctatttatg taggatgaaa ggtagtctag     8880

tacctcctgt gatattatcc cattccatgc ggggtatcgt atgcttcctt cagcactacc     8940

ctttagctgt tctatatgct gccactcctc aattggatta gtctcatcct tcaatgctat     9000

catttccttt gatattggat catactaaga aaccattatt atcatgacat taacctataa     9060

aaataggcgt atcacgaggc cctttcgtc                                       9089


<210>  59
<211>  672
<212>  DNA
<213>  Saccharomyces cerevisiae

<400>  59
agttcgagtt tatcattatc aatactgcca tttcaaagaa tacgtaaata attaatagta       60

gtgattttcc taactttatt tagtcaaaaa attagccttt taattctgct gtaacccgta      120

catgcccaaa atagggggcg ggttacacag aatatataac atcgtaggtg tctgggtgaa      180

cagtttattc ctggcatcca ctaaatataa tggagcccgc tttttaagct ggcatccaga      240

aaaaaaaaga atcccagcac caaaatattg ttttcttcac caaccatcag ttcataggtc      300

cattctctta gcgcaactac agagaacagg ggcacaaaca ggcaaaaaac gggcacaacc      360

tcaatggagt gatgcaacct gcctggagta aatgatgaca caaggcaatt gacccacgca      420

tgtatctatc tcattttctt acaccttcta ttaccttctg ctctctctga tttggaaaaa      480

gctgaaaaaa aaggttgaaa ccagttccct gaaattattc ccctacttga ctaataagta      540

tataaagacg gtaggtattg attgtaattc tgtaaatcta tttcttaaac ttcttaaatt      600

ctacttttat agttagtctt ttttttagtt ttaaaacacc aagaacttag tttcgaataa      660

acacacataa ac                                                          672


<210>  60
<211>  1023
<212>  DNA
<213>  Saccharomyces cerevisiae

<400>  60
caccgcggtg gggcgcgccc tattttcgag gaccttgtca ccttgagccc aagagagcca       60

agatttaaat tttcctatga cttgatgcaa attcccaaag ctaataacat gcaagacacg      120

tacggtcaag aagacatatt tgacctctta acaggttcag acgcgactgc ctcatcagta      180

agacccgttg aaaagaactt acctgaaaaa aacgaatata tactagcgtt gaatgttagc      240

gtcaacaaca agaagtttaa tgacgcggag gccaaggcaa aaagattcct tgattacgta      300

agggagttag aatcattttg aataaaaaac acgctttttc agttcgagtt tatcattatc      360

aatactgcca tttcaaagaa tacgtaaata attaatagta gtgattttcc taactttatt      420

tagtcaaaaa attagccttt taattctgct gtaacccgta catgcccaaa atagggggcg      480

ggttacacag aatatataac atcgtaggtg tctgggtgaa cagtttattc ctggcatcca      540

ctaaatataa tggagcccgc tttttaagct ggcatccaga aaaaaaaaga atcccagcac      600

caaaatattg ttttcttcac caaccatcag ttcataggtc cattctctta gcgcaactac      660

agagaacagg ggcacaaaca ggcaaaaaac gggcacaacc tcaatggagt gatgcaacct      720

gcctggagta aatgatgaca caaggcaatt gacccacgca tgtatctatc tcattttctt      780

acaccttcta ttaccttctg ctctctctga tttggaaaaa gctgaaaaaa aaggttgaaa      840

ccagttccct gaaattattc ccctacttga ctaataagta tataaagacg gtaggtattg      900

attgtaattc tgtaaatcta tttcttaaac ttcttaaatt ctacttttat agttagtctt      960

ttttttagtt ttaaaacacc aagaacttag tttcgaataa acacacataa actagtaaac     1020

aaa                                                                   1023


<210>  61
<211>  21
<212>  DNA
<213>  artificial sequence

<220>
<223>  primer

<400>  61
caaaagctga gctccaccgc g                                                 21


<210>  62
<211>  44
<212>  DNA
<213>  artificial sequence

<220>
<223>  primer

<400>  62
gtttactagt ttatgtgtgt ttattcgaaa ctaagttctt ggtg                        44


<210>  63
<211>  8994
<212>  DNA
<213>  artificial sequence

<220>
<223>  constructed plasmid

<400>  63
ctagttctag agcggccgcc accgcggtgg agctccagct tttgttccct ttagtgaggg       60

ttaattgcgc gcttggcgta atcatggtca tagctgtttc ctgtgtgaaa ttgttatccg      120

ctcacaattc cacacaacat aggagccgga agcataaagt gtaaagcctg gggtgcctaa      180

tgagtgaggt aactcacatt aattgcgttg cgctcactgc ccgctttcca gtcgggaaac      240

ctgtcgtgcc agctgcatta atgaatcggc caacgcgcgg ggagaggcgg tttgcgtatt      300

gggcgctctt ccgcttcctc gctcactgac tcgctgcgct cggtcgttcg gctgcggcga      360

gcggtatcag ctcactcaaa ggcggtaata cggttatcca cagaatcagg ggataacgca      420

ggaaagaaca tgtgagcaaa aggccagcaa aaggccagga accgtaaaaa ggccgcgttg      480

ctggcgtttt tccataggct ccgcccccct gacgagcatc acaaaaatcg acgctcaagt      540

cagaggtggc gaaacccgac aggactataa agataccagg cgtttccccc tggaagctcc      600

ctcgtgcgct ctcctgttcc gaccctgccg cttaccggat acctgtccgc ctttctccct      660

tcgggaagcg tggcgctttc tcatagctca cgctgtaggt atctcagttc ggtgtaggtc      720

gttcgctcca agctgggctg tgtgcacgaa ccccccgttc agcccgaccg ctgcgcctta      780

tccggtaact atcgtcttga gtccaacccg gtaagacacg acttatcgcc actggcagca      840

gccactggta acaggattag cagagcgagg tatgtaggcg gtgctacaga gttcttgaag      900

tggtggccta actacggcta cactagaagg acagtatttg gtatctgcgc tctgctgaag      960

ccagttacct tcggaaaaag agttggtagc tcttgatccg gcaaacaaac caccgctggt     1020

agcggtggtt tttttgtttg caagcagcag attacgcgca gaaaaaaagg atctcaagaa     1080

gatcctttga tcttttctac ggggtctgac gctcagtgga acgaaaactc acgttaaggg     1140

attttggtca tgagattatc aaaaaggatc ttcacctaga tccttttaaa ttaaaaatga     1200

agttttaaat caatctaaag tatatatgag taaacttggt ctgacagtta ccaatgctta     1260

atcagtgagg cacctatctc agcgatctgt ctatttcgtt catccatagt tgcctgactc     1320

cccgtcgtgt agataactac gatacgggag ggcttaccat ctggccccag tgctgcaatg     1380

ataccgcgag acccacgctc accggctcca gatttatcag caataaacca gccagccgga     1440

agggccgagc gcagaagtgg tcctgcaact ttatccgcct ccatccagtc tattaattgt     1500

tgccgggaag ctagagtaag tagttcgcca gttaatagtt tgcgcaacgt tgttgccatt     1560

gctacaggca tcgtggtgtc acgctcgtcg tttggtatgg cttcattcag ctccggttcc     1620

caacgatcaa ggcgagttac atgatccccc atgttgtgca aaaaagcggt tagctccttc     1680

ggtcctccga tcgttgtcag aagtaagttg gccgcagtgt tatcactcat ggttatggca     1740

gcactgcata attctcttac tgtcatgcca tccgtaagat gcttttctgt gactggtgag     1800

tactcaacca agtcattctg agaatagtgt atgcggcgac cgagttgctc ttgcccggcg     1860

tcaatacggg ataataccgc gccacatagc agaactttaa aagtgctcat cattggaaaa     1920

cgttcttcgg ggcgaaaact ctcaaggatc ttaccgctgt tgagatccag ttcgatgtaa     1980

cccactcgtg cacccaactg atcttcagca tcttttactt tcaccagcgt ttctgggtga     2040

gcaaaaacag gaaggcaaaa tgccgcaaaa aagggaataa gggcgacacg gaaatgttga     2100

atactcatac tcttcctttt tcaatattat tgaagcattt atcagggtta ttgtctcatg     2160

agcggataca tatttgaatg tatttagaaa aataaacaaa taggggttcc gcgcacattt     2220

ccccgaaaag tgccacctga acgaagcatc tgtgcttcat tttgtagaac aaaaatgcaa     2280

cgcgagagcg ctaatttttc aaacaaagaa tctgagctgc atttttacag aacagaaatg     2340

caacgcgaaa gcgctatttt accaacgaag aatctgtgct tcatttttgt aaaacaaaaa     2400

tgcaacgcga gagcgctaat ttttcaaaca aagaatctga gctgcatttt tacagaacag     2460

aaatgcaacg cgagagcgct attttaccaa caaagaatct atacttcttt tttgttctac     2520

aaaaatgcat cccgagagcg ctatttttct aacaaagcat cttagattac tttttttctc     2580

ctttgtgcgc tctataatgc agtctcttga taactttttg cactgtaggt ccgttaaggt     2640

tagaagaagg ctactttggt gtctattttc tcttccataa aaaaagcctg actccacttc     2700

ccgcgtttac tgattactag cgaagctgcg ggtgcatttt ttcaagataa aggcatcccc     2760

gattatattc tataccgatg tggattgcgc atactttgtg aacagaaagt gatagcgttg     2820

atgattcttc attggtcaga aaattatgaa cggtttcttc tattttgtct ctatatacta     2880

cgtataggaa atgtttacat tttcgtattg ttttcgattc actctatgaa tagttcttac     2940

tacaattttt ttgtctaaag agtaatacta gagataaaca taaaaaatgt agaggtcgag     3000

tttagatgca agttcaagga gcgaaaggtg gatgggtagg ttatataggg atatagcaca     3060

gagatatata gcaaagagat acttttgagc aatgtttgtg gaagcggtat tcgcaatatt     3120

ttagtagctc gttacagtcc ggtgcgtttt tggttttttg aaagtgcgtc ttcagagcgc     3180

ttttggtttt caaaagcgct ctgaagttcc tatactttct agagaatagg aacttcggaa     3240

taggaacttc aaagcgtttc cgaaaacgag cgcttccgaa aatgcaacgc gagctgcgca     3300

catacagctc actgttcacg tcgcacctat atctgcgtgt tgcctgtata tatatataca     3360

tgagaagaac ggcatagtgc gtgtttatgc ttaaatgcgt acttatatgc gtctatttat     3420

gtaggatgaa aggtagtcta gtacctcctg tgatattatc ccattccatg cggggtatcg     3480

tatgcttcct tcagcactac cctttagctg ttctatatgc tgccactcct caattggatt     3540

agtctcatcc ttcaatgcta tcatttcctt tgatattgga tcatactaag aaaccattat     3600

tatcatgaca ttaacctata aaaataggcg tatcacgagg ccctttcgtc tcgcgcgttt     3660

cggtgatgac ggtgaaaacc tctgacacat gcagctcccg gagacggtca cagcttgtct     3720

gtaagcggat gccgggagca gacaagcccg tcagggcgcg tcagcgggtg ttggcgggtg     3780

tcggggctgg cttaactatg cggcatcaga gcagattgta ctgagagtgc accatatcga     3840

ctacgtcgta aggccgtttc tgacagagta aaattcttga gggaactttc accattatgg     3900

gaaatgcttc aagaaggtat tgacttaaac tccatcaaat ggtcaggtca ttgagtgttt     3960

tttatttgtt gtattttttt ttttttagag aaaatcctcc aatatcaaat taggaatcgt     4020

agtttcatga ttttctgtta cacctaactt tttgtgtggt gccctcctcc ttgtcaatat     4080

taatgttaaa gtgcaattct ttttccttat cacgttgagc cattagtatc aatttgctta     4140

cctgtattcc tttactatcc tcctttttct ccttcttgat aaatgtatgt agattgcgta     4200

tatagtttcg tctaccctat gaacatattc cattttgtaa tttcgtgtcg tttctattat     4260

gaatttcatt tataaagttt atgtacaaat atcataaaaa aagagaatct ttttaagcaa     4320

ggattttctt aacttcttcg gcgacagcat caccgacttc ggtggtactg ttggaaccac     4380

ctaaatcacc agttctgata cctgcatcca aaaccttttt aactgcatct tcaatggcct     4440

taccttcttc aggcaagttc aatgacaatt tcaacatcat tgcagcagac aagatagtgg     4500

cgatagggtc aaccttattc tttggcaaat ctggagcaga accgtggcat ggttcgtaca     4560

aaccaaatgc ggtgttcttg tctggcaaag aggccaagga cgcagatggc aacaaaccca     4620

aggaacctgg gataacggag gcttcatcgg agatgatatc accaaacatg ttgctggtga     4680

ttataatacc atttaggtgg gttgggttct taactaggat catggcggca gaatcaatca     4740

attgatgttg aaccttcaat gtagggaatt cgttcttgat ggtttcctcc acagtttttc     4800

tccataatct tgaagaggcc aaaagattag ctttatccaa ggaccaaata ggcaatggtg     4860

gctcatgttg tagggccatg aaagcggcca ttcttgtgat tctttgcact tctggaacgg     4920

tgtattgttc actatcccaa gcgacaccat caccatcgtc ttcctttctc ttaccaaagt     4980

aaatacctcc cactaattct ctgacaacaa cgaagtcagt acctttagca aattgtggct     5040

tgattggaga taagtctaaa agagagtcgg atgcaaagtt acatggtctt aagttggcgt     5100

acaattgaag ttctttacgg atttttagta aaccttgttc aggtctaaca ctaccggtac     5160

cccatttagg accagccaca gcacctaaca aaacggcatc aaccttcttg gaggcttcca     5220

gcgcctcatc tggaagtggg acacctgtag catcgatagc agcaccacca attaaatgat     5280

tttcgaaatc gaacttgaca ttggaacgaa catcagaaat agctttaaga accttaatgg     5340

cttcggctgt gatttcttga ccaacgtggt cacctggcaa aacgacgatc ttcttagggg     5400

cagacatagg ggcagacatt agaatggtat atccttgaaa tatatatata tattgctgaa     5460

atgtaaaagg taagaaaagt tagaaagtaa gacgattgct aaccacctat tggaaaaaac     5520

aataggtcct taaataatat tgtcaacttc aagtattgtg atgcaagcat ttagtcatga     5580

acgcttctct attctatatg aaaagccggt tccggcctct cacctttcct ttttctccca     5640

atttttcagt tgaaaaaggt atatgcgtca ggcgacctct gaaattaaca aaaaatttcc     5700

agtcatcgaa tttgattctg tgcgatagcg cccctgtgtg ttctcgttat gttgaggaaa     5760

aaaataatgg ttgctaagag attcgaactc ttgcatctta cgatacctga gtattcccac     5820

agttaactgc ggtcaagata tttcttgaat caggcgcctt agaccgctcg gccaaacaac     5880

caattacttg ttgagaaata gagtataatt atcctataaa tataacgttt ttgaacacac     5940

atgaacaagg aagtacagga caattgattt tgaagagaat gtggattttg atgtaattgt     6000

tgggattcca tttttaataa ggcaataata ttaggtatgt ggatatacta gaagttctcc     6060

tcgaccgtcg atatgcggtg tgaaataccg cacagatgcg taaggagaaa ataccgcatc     6120

aggaaattgt aaacgttaat attttgttaa aattcgcgtt aaatttttgt taaatcagct     6180

cattttttaa ccaataggcc gaaatcggca aaatccctta taaatcaaaa gaatagaccg     6240

agatagggtt gagtgttgtt ccagtttgga acaagagtcc actattaaag aacgtggact     6300

ccaacgtcaa agggcgaaaa accgtctatc agggcgatgg cccactacgt gaaccatcac     6360

cctaatcaag ttttttgggg tcgaggtgcc gtaaagcact aaatcggaac cctaaaggga     6420

gcccccgatt tagagcttga cggggaaagc cggcgaacgt ggcgagaaag gaagggaaga     6480

aagcgaaagg agcgggcgct agggcgctgg caagtgtagc ggtcacgctg cgcgtaacca     6540

ccacacccgc cgcgcttaat gcgccgctac agggcgcgtc gcgccattcg ccattcaggc     6600

tgcgcaactg ttgggaaggg cgatcggtgc gggcctcttc gctattacgc cagctggcga     6660

aagggggatg tgctgcaagg cgattaagtt gggtaacgcc agggttttcc cagtcacgac     6720

gttgtaaaac gacggccagt gagcgcgcgt aatacgactc actatagggc gaattgggta     6780

ccgggccccc cctcgaggtc gacggtatcg ataagcttga tatcgaattc ctgcagcccg     6840

ggggatccgc atgcttgcat ttagtcgtgc aatgtatgac tttaagattt gtgagcagga     6900

agaaaaggga gaatcttcta acgataaacc cttgaaaaac tgggtagact acgctatgtt     6960

gagttgctac gcaggctgca caattacacg agaatgctcc cgcctaggat ttaaggctaa     7020

gggacgtgca atgcagacga cagatctaaa tgaccgtgtc ggtgaagtgt tcgccaaact     7080

tttcggttaa cacatgcagt gatgcacgcg cgatggtgct aagttacata tatatatata     7140

tatatatata tagccatagt gatgtctaag taacctttat ggtatatttc ttaatgtgga     7200

aagatactag cgcgcgcacc cacacacaag cttcgtcttt tcttgaagaa aagaggaagc     7260

tcgctaaatg ggattccact ttccgttccc tgccagctga tggaaaaagg ttagtggaac     7320

gatgaagaat aaaaagagag atccactgag gtgaaatttc agctgacagc gagtttcatg     7380

atcgtgatga acaatggtaa cgagttgtgg ctgttgccag ggagggtggt tctcaacttt     7440

taatgtatgg ccaaatcgct acttgggttt gttatataac aaagaagaaa taatgaactg     7500

attctcttcc tccttcttgt cctttcttaa ttctgttgta attaccttcc tttgtaattt     7560

tttttgtaat tattcttctt aataatccaa acaaacacac atattacaat agctagctga     7620

ggatgaaggc attagtttat catggggatc acaaaatttc gttagaagac aaaccaaaac     7680

ccactctgca gaaaccaaca gacgttgtgg ttagggtgtt gaaaacaaca atttgcggta     7740

ctgacttggg aatatacaaa ggtaagaatc ctgaagtggc agatggcaga atcctgggtc     7800

atgagggcgt tggcgtcatt gaagaagtgg gcgaatccgt gacacaattc aaaaaggggg     7860

ataaagtttt aatctcctgc gttactagct gtggatcgtg tgattattgc aagaagcaac     7920

tgtattcaca ctgtagagac ggtggctgga ttttaggtta catgatcgac ggtgtccaag     7980

ccgaatacgt cagaatacca catgctgaca attcattgta taagatcccg caaactatcg     8040

atgatgaaat tgcagtacta ctgtccgata ttttacctac tggacatgaa attggtgttc     8100

aatatggtaa cgttcaacca ggcgatgctg tagcaattgt aggagcaggt cctgttggaa     8160

tgtcagtttt gttaactgct caattttact cgcctagtac cattattgtt atcgacatgg     8220

acgaaaaccg tttacaatta gcgaaggagc ttggggccac acacactatt aactccggta     8280

ctgaaaatgt tgtcgaagct gtgcatcgta tagcagccga aggagtggat gtagcaatag     8340

aagctgttgg tatacccgca acctgggaca tctgtcagga aattgtaaaa cccggcgctc     8400

atattgccaa cgtgggagtt catggtgtta aggtggactt tgaaattcaa aagttgtgga     8460

ttaagaatct aaccatcacc actggtttgg ttaacactaa tactacccca atgttgatga     8520

aggtagcctc tactgataaa ttgcctttaa agaaaatgat tactcacagg tttgagttag     8580

ctgaaatcga acacgcatat caggttttct tgaatggcgc taaagaaaaa gctatgaaga     8640

ttattctatc taatgcaggt gccgcctaat taattaagag taagcgaatt tcttatgatt     8700

tatgattttt attattaaat aagttataaa aaaaataagt gtatacaaat tttaaagtga     8760

ctcttaggtt ttaaaacgaa aattcttatt cttgagtaac tctttcctgt aggtcaggtt     8820

gctttctcag gtatagcatg aggtcgctct tattgaccac acctctaccg gcatgccgag     8880

caaatgcctg caaatcgctc cccatttcac ccaattgtag atatgctaac tccagcaatg     8940

agttgatgaa tctcggtgtg tattttatgt cctcagagga caacacctgt ggta           8994


<210>  64
<211>  753
<212>  DNA
<213>  Saccharomyces cerevisiae

<400>  64
gcatgcttgc atttagtcgt gcaatgtatg actttaagat ttgtgagcag gaagaaaagg       60

gagaatcttc taacgataaa cccttgaaaa actgggtaga ctacgctatg ttgagttgct      120

acgcaggctg cacaattaca cgagaatgct cccgcctagg atttaaggct aagggacgtg      180

caatgcagac gacagatcta aatgaccgtg tcggtgaagt gttcgccaaa cttttcggtt      240

aacacatgca gtgatgcacg cgcgatggtg ctaagttaca tatatatata tatagccata      300

gtgatgtcta agtaaccttt atggtatatt tcttaatgtg gaaagatact agcgcgcgca      360

cccacacaca agcttcgtct tttcttgaag aaaagaggaa gctcgctaaa tgggattcca      420

ctttccgttc cctgccagct gatggaaaaa ggttagtgga acgatgaaga ataaaaagag      480

agatccactg aggtgaaatt tcagctgaca gcgagtttca tgatcgtgat gaacaatggt      540

aacgagttgt ggctgttgcc agggagggtg gttctcaact tttaatgtat ggccaaatcg      600

ctacttgggt ttgttatata acaaagaaga aataatgaac tgattctctt cctccttctt      660

gtcctttctt aattctgttg taattacctt cctttgtaat tttttttgta attattcttc      720

ttaataatcc aaacaaacac acatattaca ata                                   753


<210>  65
<211>  316
<212>  DNA
<213>  Saccharomyces cerevisiae

<400>  65
gagtaagcga atttcttatg atttatgatt tttattatta aataagttat aaaaaaaata       60

agtgtataca aattttaaag tgactcttag gttttaaaac gaaaattctt attcttgagt      120

aactctttcc tgtaggtcag gttgctttct caggtatagc atgaggtcgc tcttattgac      180

cacacctcta ccggcatgcc gagcaaatgc ctgcaaatcg ctccccattt cacccaattg      240

tagatatgct aactccagca atgagttgat gaatctcggt gtgtatttta tgtcctcaga      300

ggacaacacc tgtggt                                                      316


<210>  66
<211>  39
<212>  DNA
<213>  artificial sequence

<220>
<223>  primer

<400>  66
cacacatatt acaatagcta gctgaggatg aaagctctg                              39


<210>  67
<211>  39
<212>  DNA
<213>  artificial sequence

<220>
<223>  primer

<400>  67
cagagctttc atcctcagct agctattgta atatgtgtg                              39


<210>  68
<211>  9491
<212>  DNA
<213>  artificial sequence

<220>
<223>  constructed plasmid

<400>  68
tcgcgcgttt cggtgatgac ggtgaaaacc tctgacacat gcagctcccg gagacggtca       60

cagcttgtct gtaagcggat gccgggagca gacaagcccg tcagggcgcg tcagcgggtg      120

ttggcgggtg tcggggctgg cttaactatg cggcatcaga gcagattgta ctgagagtgc      180

accataaatt cccgttttaa gagcttggtg agcgctagga gtcactgcca ggtatcgttt      240

gaacacggca ttagtcaggg aagtcataac acagtccttt cccgcaattt tctttttcta      300

ttactcttgg cctcctctag tacactctat atttttttat gcctcggtaa tgattttcat      360

tttttttttt cccctagcgg atgactcttt ttttttctta gcgattggca ttatcacata      420

atgaattata cattatataa agtaatgtga tttcttcgaa gaatatacta aaaaatgagc      480

aggcaagata aacgaaggca aagatgacag agcagaaagc cctagtaaag cgtattacaa      540

atgaaaccaa gattcagatt gcgatctctt taaagggtgg tcccctagcg atagagcact      600

cgatcttccc agaaaaagag gcagaagcag tagcagaaca ggccacacaa tcgcaagtga      660

ttaacgtcca cacaggtata gggtttctgg accatatgat acatgctctg gccaagcatt      720

ccggctggtc gctaatcgtt gagtgcattg gtgacttaca catagacgac catcacacca      780

ctgaagactg cgggattgct ctcggtcaag cttttaaaga ggccctactg gcgcgtggag      840

taaaaaggtt tggatcagga tttgcgcctt tggatgaggc actttccaga gcggtggtag      900

atctttcgaa caggccgtac gcagttgtcg aacttggttt gcaaagggag aaagtaggag      960

atctctcttg cgagatgatc ccgcattttc ttgaaagctt tgcagaggct agcagaatta     1020

ccctccacgt tgattgtctg cgaggcaaga atgatcatca ccgtagtgag agtgcgttca     1080

aggctcttgc ggttgccata agagaagcca cctcgcccaa tggtaccaac gatgttccct     1140

ccaccaaagg tgttcttatg tagtgacacc gattatttaa agctgcagca tacgatatat     1200

atacatgtgt atatatgtat acctatgaat gtcagtaagt atgtatacga acagtatgat     1260

actgaagatg acaaggtaat gcatcattct atacgtgtca ttctgaacga ggcgcgcttt     1320

ccttttttct ttttgctttt tctttttttt tctcttgaac tcgacggatc tatgcggtgt     1380

gaaataccgc acagatgcgt aaggagaaaa taccgcatca ggaaattgta aacgttaata     1440

ttttgttaaa attcgcgtta aatttttgtt aaatcagctc attttttaac caataggccg     1500

aaatcggcaa aatcccttat aaatcaaaag aatagaccga gatagggttg agtgttgttc     1560

cagtttggaa caagagtcca ctattaaaga acgtggactc caacgtcaaa gggcgaaaaa     1620

ccgtctatca gggcgatggc ccactacgtg aaccatcacc ctaatcaagt tttttggggt     1680

cgaggtgccg taaagcacta aatcggaacc ctaaagggag cccccgattt agagcttgac     1740

ggggaaagcc ggcgaacgtg gcgagaaagg aagggaagaa agcgaaagga gcgggcgcta     1800

gggcgctggc aagtgtagcg gtcacgctgc gcgtaaccac cacacccgcc gcgcttaatg     1860

cgccgctaca gggcgcgtcg cgccattcgc cattcaggct gcgcaactgt tgggaagggc     1920

gatcggtgcg ggcctcttcg ctattacgcc agctggcgaa agggggatgt gctgcaaggc     1980

gattaagttg ggtaacgcca gggttttccc agtcacgacg ttgtaaaacg acggccagtg     2040

agcgcgcgta atacgactca ctatagggcg aattgggtac cgggcccccc ctcgaggtcg     2100

acggcgcgcc actggtagag agcgactttg tatgccccaa ttgcgaaacc cgcgatatcc     2160

ttctcgattc tttagtaccc gaccaggaca aggaaaagga ggtcgaaacg tttttgaaga     2220

aacaagagga actacacgga agctctaaag atggcaacca gccagaaact aagaaaatga     2280

agttgatgga tccaactggc accgctggct tgaacaacaa taccagcctt ccaacttctg     2340

taaataacgg cggtacgcca gtgccaccag taccgttacc tttcggtata cctcctttcc     2400

ccatgtttcc aatgcccttc atgcctccaa cggctactat cacaaatcct catcaagctg     2460

acgcaagccc taagaaatga ataacaatac tgacagtact aaataattgc ctacttggct     2520

tcacatacgt tgcatacgtc gatatagata ataatgataa tgacagcagg attatcgtaa     2580

tacgtaatag ttgaaaatct caaaaatgtg tgggtcatta cgtaaataat gataggaatg     2640

ggattcttct atttttcctt tttccattct agcagccgtc gggaaaacgt ggcatcctct     2700

ctttcgggct caattggagt cacgctgccg tgagcatcct ctctttccat atctaacaac     2760

tgagcacgta accaatggaa aagcatgagc ttagcgttgc tccaaaaaag tattggatgg     2820

ttaataccat ttgtctgttc tcttctgact ttgactcctc aaaaaaaaaa aatctacaat     2880

caacagatcg cttcaattac gccctcacaa aaactttttt ccttcttctt cgcccacgtt     2940

aaattttatc cctcatgttg tctaacggat ttctgcactt gatttattat aaaaagacaa     3000

agacataata cttctctatc aatttcagtt attgttcttc cttgcgttat tcttctgttc     3060

ttctttttct tttgtcatat ataaccataa ccaagtaata catattcaaa ctagtatgac     3120

tgacaaaaaa actcttaaag acttaagaaa tcgtagttct gtttacgatt caatggttaa     3180

atcacctaat cgtgctatgt tgcgtgcaac tggtatgcaa gatgaagact ttgaaaaacc     3240

tatcgtcggt gtcatttcaa cttgggctga aaacacacct tgtaatatcc acttacatga     3300

ctttggtaaa ctagccaaag tcggtgttaa ggaagctggt gcttggccag ttcagttcgg     3360

aacaatcacg gtttctgatg gaatcgccat gggaacccaa ggaatgcgtt tctccttgac     3420

atctcgtgat attattgcag attctattga agcagccatg ggaggtcata atgcggatgc     3480

ttttgtagcc attggcggtt gtgataaaaa catgcccggt tctgttatcg ctatggctaa     3540

catggatatc ccagccattt ttgcttacgg cggaacaatt gcacctggta atttagacgg     3600

caaagatatc gatttagtct ctgtctttga aggtgtcggc cattggaacc acggcgatat     3660

gaccaaagaa gaagttaaag ctttggaatg taatgcttgt cccggtcctg gaggctgcgg     3720

tggtatgtat actgctaaca caatggcgac agctattgaa gttttgggac ttagccttcc     3780

gggttcatct tctcacccgg ctgaatccgc agaaaagaaa gcagatattg aagaagctgg     3840

tcgcgctgtt gtcaaaatgc tcgaaatggg cttaaaacct tctgacattt taacgcgtga     3900

agcttttgaa gatgctatta ctgtaactat ggctctggga ggttcaacca actcaaccct     3960

tcacctctta gctattgccc atgctgctaa tgtggaattg acacttgatg atttcaatac     4020

tttccaagaa aaagttcctc atttggctga tttgaaacct tctggtcaat atgtattcca     4080

agacctttac aaggtcggag gggtaccagc agttatgaaa tatctcctta aaaatggctt     4140

ccttcatggt gaccgtatca cttgtactgg caaaacagtc gctgaaaatt tgaaggcttt     4200

tgatgattta acacctggtc aaaaggttat tatgccgctt gaaaatccta aacgtgaaga     4260

tggtccgctc attattctcc atggtaactt ggctccagac ggtgccgttg ccaaagtttc     4320

tggtgtaaaa gtgcgtcgtc atgtcggtcc tgctaaggtc tttaattctg aagaagaagc     4380

cattgaagct gtcttgaatg atgatattgt tgatggtgat gttgttgtcg tacgttttgt     4440

aggaccaaag ggcggtcctg gtatgcctga aatgctttcc ctttcatcaa tgattgttgg     4500

taaagggcaa ggtgaaaaag ttgcccttct gacagatggc cgcttctcag gtggtactta     4560

tggtcttgtc gtgggtcata tcgctcctga agcacaagat ggcggtccaa tcgcctacct     4620

gcaaacagga gacatagtca ctattgacca agacactaag gaattacact ttgatatctc     4680

cgatgaagag ttaaaacatc gtcaagagac cattgaattg ccaccgctct attcacgcgg     4740

tatccttggt aaatatgctc acatcgtttc gtctgcttct aggggagccg taacagactt     4800

ttggaagcct gaagaaactg gcaaaaaatg ttgtcctggt tgctgtggtt aagcggccgc     4860

gttaattcaa attaattgat atagtttttt aatgagtatt gaatctgttt agaaataatg     4920

gaatattatt tttatttatt tatttatatt attggtcggc tcttttcttc tgaaggtcaa     4980

tgacaaaatg atatgaagga aataatgatt tctaaaattt tacaacgtaa gatattttta     5040

caaaagccta gctcatcttt tgtcatgcac tattttactc acgcttgaaa ttaacggcca     5100

gtccactgcg gagtcatttc aaagtcatcc taatcgatct atcgtttttg atagctcatt     5160

ttggagttcg cgattgtctt ctgttattca caactgtttt aatttttatt tcattctgga     5220

actcttcgag ttctttgtaa agtctttcat agtagcttac tttatcctcc aacatattta     5280

acttcatgtc aatttcggct cttaaatttt ccacatcatc aagttcaaca tcatctttta     5340

acttgaattt attctctagc tcttccaacc aagcctcatt gctccttgat ttactggtga     5400

aaagtgatac actttgcgcg caatccaggt caaaactttc ctgcaaagaa ttcaccaatt     5460

tctcgacatc atagtacaat ttgttttgtt ctcccatcac aatttaatat acctgatgga     5520

ttcttatgaa gcgctgggta atggacgtgt cactctactt cgcctttttc cctactcctt     5580

ttagtacgga agacaatgct aataaataag agggtaataa taatattatt aatcggcaaa     5640

aaagattaaa cgccaagcgt ttaattatca gaaagcaaac gtcgtaccaa tccttgaatg     5700

cttcccaatt gtatattaag agtcatcaca gcaacatatt cttgttatta aattaattat     5760

tattgatttt tgatattgta taaaaaaacc aaatatgtat aaaaaaagtg aataaaaaat     5820

accaagtatg gagaaatata ttagaagtct atacgttaaa ccaccgcggt ggagctccag     5880

cttttgttcc ctttagtgag ggttaattgc gcgcttggcg taatcatggt catagctgtt     5940

tcctgtgtga aattgttatc cgctcacaat tccacacaac ataggagccg gaagcataaa     6000

gtgtaaagcc tggggtgcct aatgagtgag gtaactcaca ttaattgcgt tgcgctcact     6060

gcccgctttc cagtcgggaa acctgtcgtg ccagctgcat taatgaatcg gccaacgcgc     6120

ggggagaggc ggtttgcgta ttgggcgctc ttccgcttcc tcgctcactg actcgctgcg     6180

ctcggtcgtt cggctgcggc gagcggtatc agctcactca aaggcggtaa tacggttatc     6240

cacagaatca ggggataacg caggaaagaa catgtgagca aaaggccagc aaaaggccag     6300

gaaccgtaaa aaggccgcgt tgctggcgtt tttccatagg ctccgccccc ctgacgagca     6360

tcacaaaaat cgacgctcaa gtcagaggtg gcgaaacccg acaggactat aaagatacca     6420

ggcgtttccc cctggaagct ccctcgtgcg ctctcctgtt ccgaccctgc cgcttaccgg     6480

atacctgtcc gcctttctcc cttcgggaag cgtggcgctt tctcatagct cacgctgtag     6540

gtatctcagt tcggtgtagg tcgttcgctc caagctgggc tgtgtgcacg aaccccccgt     6600

tcagcccgac cgctgcgcct tatccggtaa ctatcgtctt gagtccaacc cggtaagaca     6660

cgacttatcg ccactggcag cagccactgg taacaggatt agcagagcga ggtatgtagg     6720

cggtgctaca gagttcttga agtggtggcc taactacggc tacactagaa ggacagtatt     6780

tggtatctgc gctctgctga agccagttac cttcggaaaa agagttggta gctcttgatc     6840

cggcaaacaa accaccgctg gtagcggtgg tttttttgtt tgcaagcagc agattacgcg     6900

cagaaaaaaa ggatctcaag aagatccttt gatcttttct acggggtctg acgctcagtg     6960

gaacgaaaac tcacgttaag ggattttggt catgagatta tcaaaaagga tcttcaccta     7020

gatcctttta aattaaaaat gaagttttaa atcaatctaa agtatatatg agtaaacttg     7080

gtctgacagt taccaatgct taatcagtga ggcacctatc tcagcgatct gtctatttcg     7140

ttcatccata gttgcctgac tccccgtcgt gtagataact acgatacggg agggcttacc     7200

atctggcccc agtgctgcaa tgataccgcg agacccacgc tcaccggctc cagatttatc     7260

agcaataaac cagccagccg gaagggccga gcgcagaagt ggtcctgcaa ctttatccgc     7320

ctccatccag tctattaatt gttgccggga agctagagta agtagttcgc cagttaatag     7380

tttgcgcaac gttgttgcca ttgctacagg catcgtggtg tcacgctcgt cgtttggtat     7440

ggcttcattc agctccggtt cccaacgatc aaggcgagtt acatgatccc ccatgttgtg     7500

caaaaaagcg gttagctcct tcggtcctcc gatcgttgtc agaagtaagt tggccgcagt     7560

gttatcactc atggttatgg cagcactgca taattctctt actgtcatgc catccgtaag     7620

atgcttttct gtgactggtg agtactcaac caagtcattc tgagaatagt gtatgcggcg     7680

accgagttgc tcttgcccgg cgtcaatacg ggataatacc gcgccacata gcagaacttt     7740

aaaagtgctc atcattggaa aacgttcttc ggggcgaaaa ctctcaagga tcttaccgct     7800

gttgagatcc agttcgatgt aacccactcg tgcacccaac tgatcttcag catcttttac     7860

tttcaccagc gtttctgggt gagcaaaaac aggaaggcaa aatgccgcaa aaaagggaat     7920

aagggcgaca cggaaatgtt gaatactcat actcttcctt tttcaatatt attgaagcat     7980

ttatcagggt tattgtctca tgagcggata catatttgaa tgtatttaga aaaataaaca     8040

aataggggtt ccgcgcacat ttccccgaaa agtgccacct gaacgaagca tctgtgcttc     8100

attttgtaga acaaaaatgc aacgcgagag cgctaatttt tcaaacaaag aatctgagct     8160

gcatttttac agaacagaaa tgcaacgcga aagcgctatt ttaccaacga agaatctgtg     8220

cttcattttt gtaaaacaaa aatgcaacgc gagagcgcta atttttcaaa caaagaatct     8280

gagctgcatt tttacagaac agaaatgcaa cgcgagagcg ctattttacc aacaaagaat     8340

ctatacttct tttttgttct acaaaaatgc atcccgagag cgctattttt ctaacaaagc     8400

atcttagatt actttttttc tcctttgtgc gctctataat gcagtctctt gataactttt     8460

tgcactgtag gtccgttaag gttagaagaa ggctactttg gtgtctattt tctcttccat     8520

aaaaaaagcc tgactccact tcccgcgttt actgattact agcgaagctg cgggtgcatt     8580

ttttcaagat aaaggcatcc ccgattatat tctataccga tgtggattgc gcatactttg     8640

tgaacagaaa gtgatagcgt tgatgattct tcattggtca gaaaattatg aacggtttct     8700

tctattttgt ctctatatac tacgtatagg aaatgtttac attttcgtat tgttttcgat     8760

tcactctatg aatagttctt actacaattt ttttgtctaa agagtaatac tagagataaa     8820

cataaaaaat gtagaggtcg agtttagatg caagttcaag gagcgaaagg tggatgggta     8880

ggttatatag ggatatagca cagagatata tagcaaagag atacttttga gcaatgtttg     8940

tggaagcggt attcgcaata ttttagtagc tcgttacagt ccggtgcgtt tttggttttt     9000

tgaaagtgcg tcttcagagc gcttttggtt ttcaaaagcg ctctgaagtt cctatacttt     9060

ctagagaata ggaacttcgg aataggaact tcaaagcgtt tccgaaaacg agcgcttccg     9120

aaaatgcaac gcgagctgcg cacatacagc tcactgttca cgtcgcacct atatctgcgt     9180

gttgcctgta tatatatata catgagaaga acggcatagt gcgtgtttat gcttaaatgc     9240

gtacttatat gcgtctattt atgtaggatg aaaggtagtc tagtacctcc tgtgatatta     9300

tcccattcca tgcggggtat cgtatgcttc cttcagcact accctttagc tgttctatat     9360

gctgccactc ctcaattgga ttagtctcat ccttcaatgc tatcatttcc tttgatattg     9420

gatcatctaa gaaaccatta ttatcatgac attaacctat aaaaataggc gtatcacgag     9480

gccctttcgt c                                                          9491


<210>  69
<211>  1000
<212>  DNA
<213>  Saccharymoces cerevisiae

<400>  69
gttaattcaa attaattgat atagtttttt aatgagtatt gaatctgttt agaaataatg       60

gaatattatt tttatttatt tatttatatt attggtcggc tcttttcttc tgaaggtcaa      120

tgacaaaatg atatgaagga aataatgatt tctaaaattt tacaacgtaa gatattttta      180

caaaagccta gctcatcttt tgtcatgcac tattttactc acgcttgaaa ttaacggcca      240

gtccactgcg gagtcatttc aaagtcatcc taatcgatct atcgtttttg atagctcatt      300

ttggagttcg cgattgtctt ctgttattca caactgtttt aatttttatt tcattctgga      360

actcttcgag ttctttgtaa agtctttcat agtagcttac tttatcctcc aacatattta      420

acttcatgtc aatttcggct cttaaatttt ccacatcatc aagttcaaca tcatctttta      480

acttgaattt attctctagc tcttccaacc aagcctcatt gctccttgat ttactggtga      540

aaagtgatac actttgcgcg caatccaggt caaaactttc ctgcaaagaa ttcaccaatt      600

tctcgacatc atagtacaat ttgttttgtt ctcccatcac aatttaatat acctgatgga      660

ttcttatgaa gcgctgggta atggacgtgt cactctactt cgcctttttc cctactcctt      720

ttagtacgga agacaatgct aataaataag agggtaataa taatattatt aatcggcaaa      780

aaagattaaa cgccaagcgt ttaattatca gaaagcaaac gtcgtaccaa tccttgaatg      840

cttcccaatt gtatattaag agtcatcaca gcaacatatt cttgttatta aattaattat      900

tattgatttt tgatattgta taaaaaaacc aaatatgtat aaaaaaagtg aataaaaaat      960

accaagtatg gagaaatata ttagaagtct atacgttaaa                           1000


<210>  70
<211>  760
<212>  PRT
<213>  Escherichia coli

<400>  70

Met Ser Glu Leu Asn Glu Lys Leu Ala Thr Ala Trp Glu Gly Phe Thr 
1               5                   10                  15      


Lys Gly Asp Trp Gln Asn Glu Val Asn Val Arg Asp Phe Ile Gln Lys 
            20                  25                  30          


Asn Tyr Thr Pro Tyr Glu Gly Asp Glu Ser Phe Leu Ala Gly Ala Thr 
        35                  40                  45              


Glu Ala Thr Thr Thr Leu Trp Asp Lys Val Met Glu Gly Val Lys Leu 
    50                  55                  60                  


Glu Asn Arg Thr His Ala Pro Val Asp Phe Asp Thr Ala Val Ala Ser 
65                  70                  75                  80  


Thr Ile Thr Ser His Asp Ala Gly Tyr Ile Asn Lys Gln Leu Glu Lys 
                85                  90                  95      


Ile Val Gly Leu Gln Thr Glu Ala Pro Leu Lys Arg Ala Leu Ile Pro 
            100                 105                 110         


Phe Gly Gly Ile Lys Met Ile Glu Gly Ser Cys Lys Ala Tyr Asn Arg 
        115                 120                 125             


Glu Leu Asp Pro Met Ile Lys Lys Ile Phe Thr Glu Tyr Arg Lys Thr 
    130                 135                 140                 


His Asn Gln Gly Val Phe Asp Val Tyr Thr Pro Asp Ile Leu Arg Cys 
145                 150                 155                 160 


Arg Lys Ser Gly Val Leu Thr Gly Leu Pro Asp Ala Tyr Gly Arg Gly 
                165                 170                 175     


Arg Ile Ile Gly Asp Tyr Arg Arg Val Ala Leu Tyr Gly Ile Asp Tyr 
            180                 185                 190         


Leu Met Lys Asp Lys Leu Ala Gln Phe Thr Ser Leu Gln Ala Asp Leu 
        195                 200                 205             


Glu Asn Gly Val Asn Leu Glu Gln Thr Ile Arg Leu Arg Glu Glu Ile 
    210                 215                 220                 


Ala Glu Gln His Arg Ala Leu Gly Gln Met Lys Glu Met Ala Ala Lys 
225                 230                 235                 240 


Tyr Gly Tyr Asp Ile Ser Gly Pro Ala Thr Asn Ala Gln Glu Ala Ile 
                245                 250                 255     


Gln Trp Thr Tyr Phe Gly Tyr Leu Ala Ala Val Lys Ser Gln Asn Gly 
            260                 265                 270         


Ala Ala Met Ser Phe Gly Arg Thr Ser Thr Phe Leu Asp Val Tyr Ile 
        275                 280                 285             


Glu Arg Asp Leu Lys Ala Gly Lys Ile Thr Glu Gln Glu Ala Gln Glu 
    290                 295                 300                 


Met Val Asp His Leu Val Met Lys Leu Arg Met Val Arg Phe Leu Arg 
305                 310                 315                 320 


Thr Pro Glu Tyr Asp Glu Leu Phe Ser Gly Asp Pro Ile Trp Ala Thr 
                325                 330                 335     


Glu Ser Ile Gly Gly Met Gly Leu Asp Gly Arg Thr Leu Val Thr Lys 
            340                 345                 350         


Asn Ser Phe Arg Phe Leu Asn Thr Leu Tyr Thr Met Gly Pro Ser Pro 
        355                 360                 365             


Glu Pro Asn Met Thr Ile Leu Trp Ser Glu Lys Leu Pro Leu Asn Phe 
    370                 375                 380                 


Lys Lys Phe Ala Ala Lys Val Ser Ile Asp Thr Ser Ser Leu Gln Tyr 
385                 390                 395                 400 


Glu Asn Asp Asp Leu Met Arg Pro Asp Phe Asn Asn Asp Asp Tyr Ala 
                405                 410                 415     


Ile Ala Cys Cys Val Ser Pro Met Ile Val Gly Lys Gln Met Gln Phe 
            420                 425                 430         


Phe Gly Ala Arg Ala Asn Leu Ala Lys Thr Met Leu Tyr Ala Ile Asn 
        435                 440                 445             


Gly Gly Val Asp Glu Lys Leu Lys Met Gln Val Gly Pro Lys Ser Glu 
    450                 455                 460                 


Pro Ile Lys Gly Asp Val Leu Asn Tyr Asp Glu Val Met Glu Arg Met 
465                 470                 475                 480 


Asp His Phe Met Asp Trp Leu Ala Lys Gln Tyr Ile Thr Ala Leu Asn 
                485                 490                 495     


Ile Ile His Tyr Met His Asp Lys Tyr Ser Tyr Glu Ala Ser Leu Met 
            500                 505                 510         


Ala Leu His Asp Arg Asp Val Ile Arg Thr Met Ala Cys Gly Ile Ala 
        515                 520                 525             


Gly Leu Ser Val Ala Ala Asp Ser Leu Ser Ala Ile Lys Tyr Ala Lys 
    530                 535                 540                 


Val Lys Pro Ile Arg Asp Glu Asp Gly Leu Ala Ile Asp Phe Glu Ile 
545                 550                 555                 560 


Glu Gly Glu Tyr Pro Gln Phe Gly Asn Asn Asp Pro Arg Val Asp Asp 
                565                 570                 575     


Leu Ala Val Asp Leu Val Glu Arg Phe Met Lys Lys Ile Gln Lys Leu 
            580                 585                 590         


His Thr Tyr Arg Asp Ala Ile Pro Thr Gln Ser Val Leu Thr Ile Thr 
        595                 600                 605             


Ser Asn Val Val Tyr Gly Lys Lys Thr Gly Asn Thr Pro Asp Gly Arg 
    610                 615                 620                 


Arg Ala Gly Ala Pro Phe Gly Pro Gly Ala Asn Pro Met His Gly Arg 
625                 630                 635                 640 


Asp Gln Lys Gly Ala Val Ala Ser Leu Thr Ser Val Ala Lys Leu Pro 
                645                 650                 655     


Phe Ala Tyr Ala Lys Asp Gly Ile Ser Tyr Thr Phe Ser Ile Val Pro 
            660                 665                 670         


Asn Ala Leu Gly Lys Asp Asp Glu Val Arg Lys Thr Asn Leu Ala Gly 
        675                 680                 685             


Leu Met Asp Gly Tyr Phe His His Glu Ala Ser Ile Glu Gly Gly Gln 
    690                 695                 700                 


His Leu Asn Val Asn Val Met Asn Arg Glu Met Leu Leu Asp Ala Met 
705                 710                 715                 720 


Glu Asn Pro Glu Lys Tyr Pro Gln Leu Thr Ile Arg Val Ser Gly Tyr 
                725                 730                 735     


Ala Val Arg Phe Asn Ser Leu Thr Lys Glu Gln Gln Gln Asp Val Ile 
            740                 745                 750         


Thr Arg Thr Phe Thr Gln Ser Met 
        755                 760 


<210>  71
<211>  2283
<212>  DNA
<213>  Escherichia coli

<400>  71
atgtccgagc ttaatgaaaa gttagccaca gcctgggaag gttttaccaa aggtgactgg       60

cagaatgaag taaacgtccg tgacttcatt cagaaaaact acactccgta cgagggtgac      120

gagtccttcc tggctggcgc tactgaagcg accaccaccc tgtgggacaa agtaatggaa      180

ggcgttaaac tggaaaaccg cactcacgcg ccagttgact ttgacaccgc tgttgcttcc      240

accatcacct ctcacgacgc tggctacatc aacaagcagc ttgagaaaat cgttggtctg      300

cagactgaag ctccgctgaa acgtgctctt atcccgttcg gtggtatcaa aatgatcgaa      360

ggttcctgca aagcgtacaa ccgcgaactg gatccgatga tcaaaaaaat cttcactgaa      420

taccgtaaaa ctcacaacca gggcgtgttc gacgtttaca ctccggacat cctgcgttgc      480

cgtaaatctg gtgttctgac cggtctgcca gatgcatatg gccgtggccg tatcatcggt      540

gactaccgtc gcgttgcgct gtacggtatc gactacctga tgaaagacaa actggcacag      600

ttcacttctc tgcaggctga tctggaaaac ggcgtaaacc tggaacagac tatccgtctg      660

cgcgaagaaa tcgctgaaca gcaccgcgct ctgggtcaga tgaaagaaat ggctgcgaaa      720

tacggctacg acatctctgg tccggctacc aacgctcagg aagctatcca gtggacttac      780

ttcggctacc tggctgctgt taagtctcag aacggtgctg caatgtcctt cggtcgtacc      840

tccaccttcc tggatgtgta catcgaacgt gacctgaaag ctggcaagat caccgaacaa      900

gaagcgcagg aaatggttga ccacctggtc atgaaactgc gtatggttcg cttcctgcgt      960

actccggaat acgatgaact gttctctggc gacccgatct gggcaaccga atctatcggt     1020

ggtatgggcc tcgacggtcg taccctggtt accaaaaaca gcttccgttt cctgaacacc     1080

ctgtacacca tgggtccgtc tccggaaccg aacatgacca ttctgtggtc tgaaaaactg     1140

ccgctgaact tcaagaaatt cgccgctaaa gtgtccatcg acacctcttc tctgcagtat     1200

gagaacgatg acctgatgcg tccggacttc aacaacgatg actacgctat tgcttgctgc     1260

gtaagcccga tgatcgttgg taaacaaatg cagttcttcg gtgcgcgtgc aaacctggcg     1320

aaaaccatgc tgtacgcaat caacggcggc gttgacgaaa aactgaaaat gcaggttggt     1380

ccgaagtctg aaccgatcaa aggcgatgtc ctgaactatg atgaagtgat ggagcgcatg     1440

gatcacttca tggactggct ggctaaacag tacatcactg cactgaacat catccactac     1500

atgcacgaca agtacagcta cgaagcctct ctgatggcgc tgcacgaccg tgacgttatc     1560

cgcaccatgg cgtgtggtat cgctggtctg tccgttgctg ctgactccct gtctgcaatc     1620

aaatatgcga aagttaaacc gattcgtgac gaagacggtc tggctatcga cttcgaaatc     1680

gaaggcgaat acccgcagtt tggtaacaat gatccgcgtg tagatgacct ggctgttgac     1740

ctggtagaac gtttcatgaa gaaaattcag aaactgcaca cctaccgtga cgctatcccg     1800

actcagtctg ttctgaccat cacttctaac gttgtgtatg gtaagaaaac gggtaacacc     1860

ccagacggtc gtcgtgctgg cgcgccgttc ggaccgggtg ctaacccgat gcacggtcgt     1920

gaccagaaag gtgcagtagc ctctctgact tccgttgcta aactgccgtt tgcttacgct     1980

aaagatggta tctcctacac cttctctatc gttccgaacg cactgggtaa agacgacgaa     2040

gttcgtaaga ccaacctggc tggtctgatg gatggttact tccaccacga agcatccatc     2100

gaaggtggtc agcacctgaa cgttaacgtg atgaaccgtg aaatgctgct cgacgcgatg     2160

gaaaacccgg aaaaatatcc gcagctgacc atccgtgtat ctggctacgc agtacgtttc     2220

aactcgctga ctaaagaaca gcagcaggac gttattactc gtaccttcac tcaatctatg     2280

taa                                                                   2283


<210>  72
<211>  244
<212>  PRT
<213>  Escherichia coli

<400>  72

Met Ala Glu Met Lys Asn Leu Lys Ile Glu Val Val Arg Tyr Asn Pro 
1               5                   10                  15      


Glu Val Asp Thr Ala Pro His Ser Ala Phe Tyr Glu Val Pro Tyr Asp 
            20                  25                  30          


Ala Thr Thr Ser Leu Leu Asp Ala Leu Gly Tyr Ile Lys Asp Asn Leu 
        35                  40                  45              


Ala Pro Asp Leu Ser Tyr Arg Trp Ser Cys Arg Met Ala Ile Cys Gly 
    50                  55                  60                  


Ser Cys Gly Met Met Val Asn Asn Val Pro Lys Leu Ala Cys Lys Thr 
65                  70                  75                  80  


Phe Leu Arg Asp Tyr Thr Asp Gly Met Lys Val Glu Ala Leu Ala Asn 
                85                  90                  95      


Phe Pro Ile Glu Arg Asp Leu Val Val Asp Met Thr His Phe Ile Glu 
            100                 105                 110         


Ser Leu Glu Ala Ile Lys Pro Tyr Ile Ile Gly Asn Ser Arg Thr Ala 
        115                 120                 125             


Asp Gln Gly Thr Asn Ile Gln Thr Pro Ala Gln Met Ala Lys Tyr His 
    130                 135                 140                 


Gln Phe Ser Gly Cys Ile Asn Cys Gly Leu Cys Tyr Ala Ala Cys Pro 
145                 150                 155                 160 


Gln Phe Gly Leu Asn Pro Glu Phe Ile Gly Pro Ala Ala Ile Thr Leu 
                165                 170                 175     


Ala His Arg Tyr Asn Glu Asp Ser Arg Asp His Gly Lys Lys Glu Arg 
            180                 185                 190         


Met Ala Gln Leu Asn Ser Gln Asn Gly Val Trp Ser Cys Thr Phe Val 
        195                 200                 205             


Gly Tyr Cys Ser Glu Val Cys Pro Lys His Val Asp Pro Ala Ala Ala 
    210                 215                 220                 


Ile Gln Gln Gly Lys Val Glu Ser Ser Lys Asp Phe Leu Ile Ala Thr 
225                 230                 235                 240 


Leu Lys Pro Arg 
                


<210>  73
<211>  735
<212>  DNA
<213>  Escherichia coli

<400>  73
atggctgaga tgaaaaacct gaaaattgag gtggtgcgct ataacccgga agtcgatacc       60

gcaccgcata gcgcattcta tgaagtgcct tatgacgcaa ctacctcatt actggatgcg      120

ctgggctaca tcaaagacaa cctggcaccg gacctgagct accgctggtc ctgccgtatg      180

gcgatttgtg gttcctgcgg catgatggtt aacaacgtgc caaaactggc atgtaaaacc      240

ttcctgcgtg attacaccga cggtatgaag gttgaagcgt tagctaactt cccgattgaa      300

cgcgatctgg tggtcgatat gacccacttc atcgaaagtc tggaagcgat caaaccgtac      360

atcatcggca actcccgcac cgcggatcag ggtactaaca tccagacccc ggcgcagatg      420

gcgaagtatc accagttctc cggttgcatc aactgtggtt tgtgctacgc cgcgtgcccg      480

cagtttggcc tgaacccaga gttcatcggt ccggctgcca ttacgctggc gcatcgttat      540

aacgaagata gccgcgacca cggtaagaag gagcgtatgg cgcagttgaa cagccagaac      600

ggcgtatgga gctgtacttt cgtgggctac tgctccgaag tctgcccgaa acacgtcgat      660

ccggctgcgg ccattcagca gggcaaagta gaaagttcga aagactttct tatcgcgacc      720

ctgaaaccac gctaa                                                       735


<210>  74
<211>  891
<212>  PRT
<213>  Escherichia coli

<400>  74

Met Ala Val Thr Asn Val Ala Glu Leu Asn Ala Leu Val Glu Arg Val 
1               5                   10                  15      


Lys Lys Ala Gln Arg Glu Tyr Ala Ser Phe Thr Gln Glu Gln Val Asp 
            20                  25                  30          


Lys Ile Phe Arg Ala Ala Ala Leu Ala Ala Ala Asp Ala Arg Ile Pro 
        35                  40                  45              


Leu Ala Lys Met Ala Val Ala Glu Ser Gly Met Gly Ile Val Glu Asp 
    50                  55                  60                  


Lys Val Ile Lys Asn His Phe Ala Ser Glu Tyr Ile Tyr Asn Ala Tyr 
65                  70                  75                  80  


Lys Asp Glu Lys Thr Cys Gly Val Leu Ser Glu Asp Asp Thr Phe Gly 
                85                  90                  95      


Thr Ile Thr Ile Ala Glu Pro Ile Gly Ile Ile Cys Gly Ile Val Pro 
            100                 105                 110         


Thr Thr Asn Pro Thr Ser Thr Ala Ile Phe Lys Ser Leu Ile Ser Leu 
        115                 120                 125             


Lys Thr Arg Asn Ala Ile Ile Phe Ser Pro His Pro Arg Ala Lys Asp 
    130                 135                 140                 


Ala Thr Asn Lys Ala Ala Asp Ile Val Leu Gln Ala Ala Ile Ala Ala 
145                 150                 155                 160 


Gly Ala Pro Lys Asp Leu Ile Gly Trp Ile Asp Gln Pro Ser Val Glu 
                165                 170                 175     


Leu Ser Asn Ala Leu Met His His Pro Asp Ile Asn Leu Ile Leu Ala 
            180                 185                 190         


Thr Gly Gly Pro Gly Met Val Lys Ala Ala Tyr Ser Ser Gly Lys Pro 
        195                 200                 205             


Ala Ile Gly Val Gly Ala Gly Asn Thr Pro Val Val Ile Asp Glu Thr 
    210                 215                 220                 


Ala Asp Ile Lys Arg Ala Val Ala Ser Val Leu Met Ser Lys Thr Phe 
225                 230                 235                 240 


Asp Asn Gly Val Ile Cys Ala Ser Glu Gln Ser Val Val Val Val Asp 
                245                 250                 255     


Ser Val Tyr Asp Ala Val Arg Glu Arg Phe Ala Thr His Gly Gly Tyr 
            260                 265                 270         


Leu Leu Gln Gly Lys Glu Leu Lys Ala Val Gln Asp Val Ile Leu Lys 
        275                 280                 285             


Asn Gly Ala Leu Asn Ala Ala Ile Val Gly Gln Pro Ala Tyr Lys Ile 
    290                 295                 300                 


Ala Glu Leu Ala Gly Phe Ser Val Pro Glu Asn Thr Lys Ile Leu Ile 
305                 310                 315                 320 


Gly Glu Val Thr Val Val Asp Glu Ser Glu Pro Phe Ala His Glu Lys 
                325                 330                 335     


Leu Ser Pro Thr Leu Ala Met Tyr Arg Ala Lys Asp Phe Glu Asp Ala 
            340                 345                 350         


Val Glu Lys Ala Glu Lys Leu Val Ala Met Gly Gly Ile Gly His Thr 
        355                 360                 365             


Ser Cys Leu Tyr Thr Asp Gln Asp Asn Gln Pro Ala Arg Val Ser Tyr 
    370                 375                 380                 


Phe Gly Gln Lys Met Lys Thr Ala Arg Ile Leu Ile Asn Thr Pro Ala 
385                 390                 395                 400 


Ser Gln Gly Gly Ile Gly Asp Leu Tyr Asn Phe Lys Leu Ala Pro Ser 
                405                 410                 415     


Leu Thr Leu Gly Cys Gly Ser Trp Gly Gly Asn Ser Ile Ser Glu Asn 
            420                 425                 430         


Val Gly Pro Lys His Leu Ile Asn Lys Lys Thr Val Ala Lys Arg Ala 
        435                 440                 445             


Glu Asn Met Leu Trp His Lys Leu Pro Lys Ser Ile Tyr Phe Arg Arg 
    450                 455                 460                 


Gly Ser Leu Pro Ile Ala Leu Asp Glu Val Ile Thr Asp Gly His Lys 
465                 470                 475                 480 


Arg Ala Leu Ile Val Thr Asp Arg Phe Leu Phe Asn Asn Gly Tyr Ala 
                485                 490                 495     


Asp Gln Ile Thr Ser Val Leu Lys Ala Ala Gly Val Glu Thr Glu Val 
            500                 505                 510         


Phe Phe Glu Val Glu Ala Asp Pro Thr Leu Ser Ile Val Arg Lys Gly 
        515                 520                 525             


Ala Glu Leu Ala Asn Ser Phe Lys Pro Asp Val Ile Ile Ala Leu Gly 
    530                 535                 540                 


Gly Gly Ser Pro Met Asp Ala Ala Lys Ile Met Trp Val Met Tyr Glu 
545                 550                 555                 560 


His Pro Glu Thr His Phe Glu Glu Leu Ala Leu Arg Phe Met Asp Ile 
                565                 570                 575     


Arg Lys Arg Ile Tyr Lys Phe Pro Lys Met Gly Val Lys Ala Lys Met 
            580                 585                 590         


Ile Ala Val Thr Thr Thr Ser Gly Thr Gly Ser Glu Val Thr Pro Phe 
        595                 600                 605             


Ala Val Val Thr Asp Asp Ala Thr Gly Gln Lys Tyr Pro Leu Ala Asp 
    610                 615                 620                 


Tyr Ala Leu Thr Pro Asp Met Ala Ile Val Asp Ala Asn Leu Val Met 
625                 630                 635                 640 


Asp Met Pro Lys Ser Leu Cys Ala Phe Gly Gly Leu Asp Ala Val Thr 
                645                 650                 655     


His Ala Met Glu Ala Tyr Val Ser Val Leu Ala Ser Glu Phe Ser Asp 
            660                 665                 670         


Gly Gln Ala Leu Gln Ala Leu Lys Leu Leu Lys Glu Tyr Leu Pro Ala 
        675                 680                 685             


Ser Tyr His Glu Gly Ser Lys Asn Pro Val Ala Arg Glu Arg Val His 
    690                 695                 700                 


Ser Ala Ala Thr Ile Ala Gly Ile Ala Phe Ala Asn Ala Phe Leu Gly 
705                 710                 715                 720 


Val Cys His Ser Met Ala His Lys Leu Gly Ser Gln Phe His Ile Pro 
                725                 730                 735     


His Gly Leu Ala Asn Ala Leu Leu Ile Cys Asn Val Ile Arg Tyr Asn 
            740                 745                 750         


Ala Asn Asp Asn Pro Thr Lys Gln Thr Ala Phe Ser Gln Tyr Asp Arg 
        755                 760                 765             


Pro Gln Ala Arg Arg Arg Tyr Ala Glu Ile Ala Asp His Leu Gly Leu 
    770                 775                 780                 


Ser Ala Pro Gly Asp Arg Thr Ala Ala Lys Ile Glu Lys Leu Leu Ala 
785                 790                 795                 800 


Trp Leu Glu Thr Leu Lys Ala Glu Leu Gly Ile Pro Lys Ser Ile Arg 
                805                 810                 815     


Glu Ala Gly Val Gln Glu Ala Asp Phe Leu Ala Asn Val Asp Lys Leu 
            820                 825                 830         


Ser Glu Asp Ala Phe Asp Asp Gln Cys Thr Gly Ala Asn Pro Arg Tyr 
        835                 840                 845             


Pro Leu Ile Ser Glu Leu Lys Gln Ile Leu Leu Asp Thr Tyr Tyr Gly 
    850                 855                 860                 


Arg Asp Tyr Val Glu Gly Glu Thr Ala Ala Lys Lys Glu Ala Ala Pro 
865                 870                 875                 880 


Ala Lys Ala Glu Lys Lys Ala Lys Lys Ser Ala 
                885                 890     


<210>  75
<211>  2676
<212>  DNA
<213>  Escherichia coli

<400>  75
atggctgtta ctaatgtcgc tgaacttaac gcactcgtag agcgtgtaaa aaaagcccag       60

cgtgaatatg ccagtttcac tcaagagcaa gtagacaaaa tcttccgcgc cgccgctctg      120

gctgctgcag atgctcgaat cccactcgcg aaaatggccg ttgccgaatc cggcatgggt      180

atcgtcgaag ataaagtgat caaaaaccac tttgcttctg aatatatcta caacgcctat      240

aaagatgaaa aaacctgtgg tgttctgtct gaagacgaca cttttggtac catcactatc      300

gctgaaccaa tcggtattat ttgcggtatc gttccgacca ctaacccgac ttcaactgct      360

atcttcaaat cgctgatcag tctgaagacc cgtaacgcca ttatcttctc cccgcacccg      420

cgtgcaaaag atgccaccaa caaagcggct gatatcgttc tgcaggctgc tatcgctgcc      480

ggtgctccga aagatctgat cggctggatc gatcaacctt ctgttgaact gtctaacgca      540

ctgatgcacc acccagacat caacctgatc ctcgcgactg gtggtccggg catggttaaa      600

gccgcataca gctccggtaa accagctatc ggtgtaggcg cgggcaacac tccagttgtt      660

atcgatgaaa ctgctgatat caaacgtgca gttgcatctg tactgatgtc caaaaccttc      720

gacaacggcg taatctgtgc ttctgaacag tctgttgttg ttgttgactc tgtttatgac      780

gctgtacgtg aacgttttgc aacccacggc ggctatctgt tgcagggtaa agagctgaaa      840

gctgttcagg atgttatcct gaaaaacggt gcgctgaacg cggctatcgt tggtcagcca      900

gcctataaaa ttgctgaact ggcaggcttc tctgtaccag aaaacaccaa gattctgatc      960

ggtgaagtga ccgttgttga tgaaagcgaa ccgttcgcac atgaaaaact gtccccgact     1020

ctggcaatgt accgcgctaa agatttcgaa gacgcggtag aaaaagcaga gaaactggtt     1080

gctatgggcg gtatcggtca tacctcttgc ctgtacactg accaggataa ccaaccggct     1140

cgcgtttctt acttcggtca gaaaatgaaa acggcgcgta tcctgattaa caccccagcg     1200

tctcagggtg gtatcggtga cctgtataac ttcaaactcg caccttccct gactctgggt     1260

tgtggttctt ggggtggtaa ctccatctct gaaaacgttg gtccgaaaca cctgatcaac     1320

aagaaaaccg ttgctaagcg agctgaaaac atgttgtggc acaaacttcc gaaatctatc     1380

tacttccgcc gtggctccct gccaatcgcg ctggatgaag tgattactga tggccacaaa     1440

cgtgcgctca tcgtgactga ccgcttcctg ttcaacaatg gttatgctga tcagatcact     1500

tccgtactga aagcagcagg cgttgaaact gaagtcttct tcgaagtaga agcggacccg     1560

accctgagca tcgttcgtaa aggtgcagaa ctggcaaact ccttcaaacc agacgtgatt     1620

atcgcgctgg gtggtggttc cccgatggac gccgcgaaga tcatgtgggt tatgtacgaa     1680

catccggaaa ctcacttcga agagctggcg ctgcgcttta tggatatccg taaacgtatc     1740

tacaagttcc cgaaaatggg cgtgaaagcg aaaatgatcg ctgtcaccac cacttctggt     1800

acaggttctg aagtcactcc gtttgcggtt gtaactgacg acgctactgg tcagaaatat     1860

ccgctggcag actatgcgct gactccggat atggcgattg tcgacgccaa cctggttatg     1920

gacatgccga agtccctgtg tgctttcggt ggtctggacg cagtaactca cgccatggaa     1980

gcttatgttt ctgtactggc atctgagttc tctgatggtc aggctctgca ggcactgaaa     2040

ctgctgaaag aatatctgcc agcgtcctac cacgaagggt ctaaaaatcc ggtagcgcgt     2100

gaacgtgttc acagtgcagc gactatcgcg ggtatcgcgt ttgcgaacgc cttcctgggt     2160

gtatgtcact caatggcgca caaactgggt tcccagttcc atattccgca cggtctggca     2220

aacgccctgc tgatttgtaa cgttattcgc tacaatgcga acgacaaccc gaccaagcag     2280

actgcattca gccagtatga ccgtccgcag gctcgccgtc gttatgctga aattgccgac     2340

cacttgggtc tgagcgcacc gggcgaccgt actgctgcta agatcgagaa actgctggca     2400

tggctggaaa cgctgaaagc tgaactgggt attccgaaat ctatccgtga agctggcgtt     2460

caggaagcag acttcctggc gaacgtggat aaactgtctg aagatgcatt cgatgaccag     2520

tgcaccggcg ctaacccgcg ttacccgctg atctccgagc tgaaacagat tctgctggat     2580

acctactacg gtcgtgatta tgtagaaggt gaaactgcag cgaagaaaga agctgctccg     2640

gctaaagctg agaaaaaagc gaaaaaatcc gcttaa                               2676


<210>  76
<211>  329
<212>  PRT
<213>  Escherichia coli

<400>  76

Met Lys Leu Ala Val Tyr Ser Thr Lys Gln Tyr Asp Lys Lys Tyr Leu 
1               5                   10                  15      


Gln Gln Val Asn Glu Ser Phe Gly Phe Glu Leu Glu Phe Phe Asp Phe 
            20                  25                  30          


Leu Leu Thr Glu Lys Thr Ala Lys Thr Ala Asn Gly Cys Glu Ala Val 
        35                  40                  45              


Cys Ile Phe Val Asn Asp Asp Gly Ser Arg Pro Val Leu Glu Glu Leu 
    50                  55                  60                  


Lys Lys His Gly Val Lys Tyr Ile Ala Leu Arg Cys Ala Gly Phe Asn 
65                  70                  75                  80  


Asn Val Asp Leu Asp Ala Ala Lys Glu Leu Gly Leu Lys Val Val Arg 
                85                  90                  95      


Val Pro Ala Tyr Asp Pro Glu Ala Val Ala Glu His Ala Ile Gly Met 
            100                 105                 110         


Met Met Thr Leu Asn Arg Arg Ile His Arg Ala Tyr Gln Arg Thr Arg 
        115                 120                 125             


Asp Ala Asn Phe Ser Leu Glu Gly Leu Thr Gly Phe Thr Met Tyr Gly 
    130                 135                 140                 


Lys Thr Ala Gly Val Ile Gly Thr Gly Lys Ile Gly Val Ala Met Leu 
145                 150                 155                 160 


Arg Ile Leu Lys Gly Phe Gly Met Arg Leu Leu Ala Phe Asp Pro Tyr 
                165                 170                 175     


Pro Ser Ala Ala Ala Leu Glu Leu Gly Val Glu Tyr Val Asp Leu Pro 
            180                 185                 190         


Thr Leu Phe Ser Glu Ser Asp Val Ile Ser Leu His Cys Pro Leu Thr 
        195                 200                 205             


Pro Glu Asn Tyr His Leu Leu Asn Glu Ala Ala Phe Glu Gln Met Lys 
    210                 215                 220                 


Asn Gly Val Met Ile Val Asn Thr Ser Arg Gly Ala Leu Ile Asp Ser 
225                 230                 235                 240 


Gln Ala Ala Ile Glu Ala Leu Lys Asn Gln Lys Ile Gly Ser Leu Gly 
                245                 250                 255     


Met Asp Val Tyr Glu Asn Glu Arg Asp Leu Phe Phe Glu Asp Lys Ser 
            260                 265                 270         


Asn Asp Val Ile Gln Asp Asp Val Phe Arg Arg Leu Ser Ala Cys His 
        275                 280                 285             


Asn Val Leu Phe Thr Gly His Gln Ala Phe Leu Thr Ala Glu Ala Leu 
    290                 295                 300                 


Thr Ser Ile Ser Gln Thr Thr Leu Gln Asn Leu Ser Asn Leu Glu Lys 
305                 310                 315                 320 


Gly Glu Thr Cys Pro Asn Glu Leu Val 
                325                 


<210>  77
<211>  990
<212>  DNA
<213>  Escherichia coli

<400>  77
atgaaactcg ccgtttatag cacaaaacag tacgacaaga agtacctgca acaggtgaac       60

gagtcctttg gctttgagct ggaatttttt gactttctgc tgacggaaaa aaccgctaaa      120

actgccaatg gctgcgaagc ggtatgtatt ttcgtaaacg atgacggcag ccgcccggtg      180

ctggaagagc tgaaaaagca cggcgttaaa tatatcgccc tgcgctgtgc cggtttcaat      240

aacgtcgacc ttgacgcggc aaaagaactg gggctgaaag tagtccgtgt tccagcctat      300

gatccagagg ccgttgctga acacgccatc ggtatgatga tgacgctgaa ccgccgtatt      360

caccgcgcgt atcagcgtac ccgtgatgct aacttctctc tggaaggtct gaccggcttt      420

actatgtatg gcaaaacggc aggcgttatc ggtaccggta aaatcggtgt ggcgatgctg      480

cgcattctga aaggttttgg tatgcgtctg ctggcgttcg atccgtatcc aagtgcagcg      540

gcgctggaac tcggtgtgga gtatgtcgat ctgccaaccc tgttctctga atcagacgtt      600

atctctctgc actgcccgct gacaccggaa aactatcatc tgttgaacga agccgccttc      660

gaacagatga aaaatggcgt gatgatcgtc aataccagtc gcggtgcatt gattgattct      720

caggcagcaa ttgaagcgct gaaaaatcag aaaattggtt cgttgggtat ggacgtgtat      780

gagaacgaac gcgatctatt ctttgaagat aaatccaacg acgtgatcca ggatgacgta      840

ttccgtcgcc tgtctgcctg ccacaacgtg ctgtttaccg ggcaccaggc attcctgaca      900

gcagaagctc tgaccagtat ttctcagact acgctgcaaa acttaagcaa tctggaaaaa      960

ggcgaaacct gcccgaacga actggtttaa                                       990


<210>  78
<211>  24
<212>  DNA
<213>  primer

<400>  78
tcatcactga taacctgatt ccgg                                              24


<210>  79
<211>  26
<212>  DNA
<213>  artificial sequence

<220>
<223>  primer

<400>  79
cgagtctgtt ttggcagtca ccttaa                                            26


<210>  80
<211>  23
<212>  DNA
<213>  artificial sequence

<220>
<223>  primer

<400>  80
gagcgtgacg acgtcaactt cct                                               23


<210>  81
<211>  23
<212>  DNA
<213>  artificial sequence

<220>
<223>  primer

<400>  81
cagttcaatg ctgaaccaca cag                                               23


<210>  82
<211>  23
<212>  DNA
<213>  artificial sequence

<220>
<223>  primer

<400>  82
gaaggttgcg cctacactaa gca                                               23


<210>  83
<211>  23
<212>  DNA
<213>  artificial sequence

<220>
<223>  primer

<400>  83
gggagcggca agattaaacc agt                                               23


<210>  84
<211>  23
<212>  DNA
<213>  artificial sequence

<220>
<223>  primer

<400>  84
tggatcacgt aatcagtacc cag                                               23


<210>  85
<211>  23
<212>  DNA
<213>  artificial sequence

<220>
<223>  primer

<400>  85
atccttaact gatcggcatt gcc                                               23


<210>  86
<211>  30
<212>  DNA
<213>  artificial sequence

<220>
<223>  primer

<400>  86
ggaattcaca catgaaagct ctggtttatc                                        30


<210>  87
<211>  28
<212>  DNA
<213>  artificial sequence

<220>
<223>  primer

<400>  87
gcgtccaggg cgtcaaagat caggcagc                                          28


<210>  88
<211>  30
<212>  DNA
<213>  artificial sequence

<220>
<223>  primer

<400>  88
gacctaggag gtcacacatg aaagctctgg                                        30


<210>  89
<211>  25
<212>  DNA
<213>  artificial sequence

<220>
<223>  primer

<400>  89
cgactctaga ggatccccgg gtacc                                             25


<210>  90
<211>  602
<212>  PRT
<213>  Escherichia coli

<400>  90

Met Gln Thr Phe Gln Ala Asp Leu Ala Ile Val Gly Ala Gly Gly Ala 
1               5                   10                  15      


Gly Leu Arg Ala Ala Ile Ala Ala Ala Gln Ala Asn Pro Asn Ala Lys 
            20                  25                  30          


Ile Ala Leu Ile Ser Lys Val Tyr Pro Met Arg Ser His Thr Val Ala 
        35                  40                  45              


Ala Glu Gly Gly Ser Ala Ala Val Ala Gln Asp His Asp Ser Phe Glu 
    50                  55                  60                  


Tyr His Phe His Asp Thr Val Ala Gly Gly Asp Trp Leu Cys Glu Gln 
65                  70                  75                  80  


Asp Val Val Asp Tyr Phe Val His His Cys Pro Thr Glu Met Thr Gln 
                85                  90                  95      


Leu Glu Leu Trp Gly Cys Pro Trp Ser Arg Arg Pro Asp Gly Ser Val 
            100                 105                 110         


Asn Val Arg Arg Phe Gly Gly Met Lys Ile Glu Arg Thr Trp Phe Ala 
        115                 120                 125             


Ala Asp Lys Thr Gly Phe His Met Leu His Thr Leu Phe Gln Thr Ser 
    130                 135                 140                 


Leu Gln Phe Pro Gln Ile Gln Arg Phe Asp Glu His Phe Val Leu Asp 
145                 150                 155                 160 


Ile Leu Val Asp Asp Gly His Val Arg Gly Leu Val Ala Met Asn Met 
                165                 170                 175     


Met Glu Gly Thr Leu Val Gln Ile Arg Ala Asn Ala Val Val Met Ala 
            180                 185                 190         


Thr Gly Gly Ala Gly Arg Val Tyr Arg Tyr Asn Thr Asn Gly Gly Ile 
        195                 200                 205             


Val Thr Gly Asp Gly Met Gly Met Ala Leu Ser His Gly Val Pro Leu 
    210                 215                 220                 


Arg Asp Met Glu Phe Val Gln Tyr His Pro Thr Gly Leu Pro Gly Ser 
225                 230                 235                 240 


Gly Ile Leu Met Thr Glu Gly Cys Arg Gly Glu Gly Gly Ile Leu Val 
                245                 250                 255     


Asn Lys Asn Gly Tyr Arg Tyr Leu Gln Asp Tyr Gly Met Gly Pro Glu 
            260                 265                 270         


Thr Pro Leu Gly Glu Pro Lys Asn Lys Tyr Met Glu Leu Gly Pro Arg 
        275                 280                 285             


Asp Lys Val Ser Gln Ala Phe Trp His Glu Trp Arg Lys Gly Asn Thr 
    290                 295                 300                 


Ile Ser Thr Pro Arg Gly Asp Val Val Tyr Leu Asp Leu Arg His Leu 
305                 310                 315                 320 


Gly Glu Lys Lys Leu His Glu Arg Leu Pro Phe Ile Cys Glu Leu Ala 
                325                 330                 335     


Lys Ala Tyr Val Gly Val Asp Pro Val Lys Glu Pro Ile Pro Val Arg 
            340                 345                 350         


Pro Thr Ala His Tyr Thr Met Gly Gly Ile Glu Thr Asp Gln Asn Cys 
        355                 360                 365             


Glu Thr Arg Ile Lys Gly Leu Phe Ala Val Gly Glu Cys Ser Ser Val 
    370                 375                 380                 


Gly Leu His Gly Ala Asn Arg Leu Gly Ser Asn Ser Leu Ala Glu Leu 
385                 390                 395                 400 


Val Val Phe Gly Arg Leu Ala Gly Glu Gln Ala Thr Glu Arg Ala Ala 
                405                 410                 415     


Thr Ala Gly Asn Gly Asn Glu Ala Ala Ile Glu Ala Gln Ala Ala Gly 
            420                 425                 430         


Val Glu Gln Arg Leu Lys Asp Leu Val Asn Gln Asp Gly Gly Glu Asn 
        435                 440                 445             


Trp Ala Lys Ile Arg Asp Glu Met Gly Leu Ala Met Glu Glu Gly Cys 
    450                 455                 460                 


Gly Ile Tyr Arg Thr Pro Glu Leu Met Gln Lys Thr Ile Asp Lys Leu 
465                 470                 475                 480 


Ala Glu Leu Gln Glu Arg Phe Lys Arg Val Arg Ile Thr Asp Thr Ser 
                485                 490                 495     


Ser Val Phe Asn Thr Asp Leu Leu Tyr Thr Ile Glu Leu Gly His Gly 
            500                 505                 510         


Leu Asn Val Ala Glu Cys Met Ala His Ser Ala Met Ala Arg Lys Glu 
        515                 520                 525             


Ser Arg Gly Ala His Gln Arg Leu Asp Glu Gly Cys Thr Glu Arg Asp 
    530                 535                 540                 


Asp Val Asn Phe Leu Lys His Thr Leu Ala Phe Arg Asp Ala Asp Gly 
545                 550                 555                 560 


Thr Thr Arg Leu Glu Tyr Ser Asp Val Lys Ile Thr Thr Leu Pro Pro 
                565                 570                 575     


Ala Lys Arg Val Tyr Gly Gly Glu Ala Asp Ala Ala Asp Lys Ala Glu 
            580                 585                 590         


Ala Ala Asn Lys Lys Glu Lys Ala Asn Gly 
        595                 600         


<210>  91
<211>  1809
<212>  DNA
<213>  Escherichia coli

<400>  91
gtgcaaacct ttcaagccga tcttgccatt gtaggcgccg gtggcgcggg attacgtgct       60

gcaattgctg ccgcgcaggc aaatccgaat gcaaaaatcg cactaatctc aaaagtatac      120

ccgatgcgta gccataccgt tgctgcagaa gggggctccg ccgctgtcgc gcaggatcat      180

gacagcttcg aatatcactt tcacgataca gtagcgggtg gcgactggtt gtgtgagcag      240

gatgtcgtgg attatttcgt ccaccactgc ccaaccgaaa tgacccaact ggaactgtgg      300

ggatgcccat ggagccgtcg cccggatggt agcgtcaacg tacgtcgctt cggcggcatg      360

aaaatcgagc gcacctggtt cgccgccgat aagaccggct tccatatgct gcacacgctg      420

ttccagacct ctctgcaatt cccgcagatc cagcgttttg acgaacattt cgtgctggat      480

attctggttg atgatggtca tgttcgcggc ctggtagcaa tgaacatgat ggaaggcacg      540

ctggtgcaga tccgtgctaa cgcggtcgtt atggctactg gcggtgcggg tcgcgtttat      600

cgttacaaca ccaacggcgg catcgttacc ggtgacggta tgggtatggc gctaagccac      660

ggcgttccgc tgcgtgacat ggaattcgtt cagtatcacc caaccggtct gccaggttcc      720

ggtatcctga tgaccgaagg ttgccgcggt gaaggcggta ttctggtcaa caaaaatggc      780

taccgttatc tgcaagatta cggcatgggc ccggaaactc cgctgggcga gccgaaaaac      840

aaatatatgg aactgggtcc acgcgacaaa gtctctcagg ccttctggca cgaatggcgt      900

aaaggcaaca ccatctccac gccgcgtggc gatgtggttt atctcgactt gcgtcacctc      960

ggcgagaaaa aactgcatga acgtctgccg ttcatctgcg aactggcgaa agcgtacgtt     1020

ggcgtcgatc cggttaaaga accgattccg gtacgtccga ccgcacacta caccatgggc     1080

ggtatcgaaa ccgatcagaa ctgtgaaacc cgcattaaag gtctgttcgc cgtgggtgaa     1140

tgttcctctg ttggtctgca cggtgcaaac cgtctgggtt ctaactccct ggcggaactg     1200

gtggtcttcg gccgtctggc cggtgaacaa gcgacagagc gtgcagcaac tgccggtaat     1260

ggcaacgaag cggcaattga agcgcaggca gctggcgttg aacaacgtct gaaagatctg     1320

gttaaccagg atggcggcga aaactgggcg aagatccgcg acgaaatggg cctggctatg     1380

gaagaaggct gcggtatcta ccgtacgccg gaactgatgc agaaaaccat cgacaagctg     1440

gcagagctgc aggaacgctt caagcgcgtg cgcatcaccg acacttccag cgtgttcaac     1500

accgacctgc tctacaccat tgaactgggc cacggtctga acgttgctga atgtatggcg     1560

cactccgcaa tggcacgtaa agagtcccgc ggcgcgcacc agcgtctgga cgaaggttgc     1620

accgagcgtg acgacgtcaa cttcctcaaa cacaccctcg ccttccgcga tgctgatggc     1680

acgactcgcc tggagtacag cgacgtgaag attactacgc tgccgccagc taaacgcgtt     1740

tacggtggcg aagcggatgc agccgataag gcggaagcag ccaataagaa ggagaaggcg     1800

aatggctga                                                             1809


<210>  92
<211>  131
<212>  PRT
<213>  Escherichia coli

<400>  92

Met Thr Thr Lys Arg Lys Pro Tyr Val Arg Pro Met Thr Ser Thr Trp 
1               5                   10                  15      


Trp Lys Lys Leu Pro Phe Tyr Arg Phe Tyr Met Leu Arg Glu Gly Thr 
            20                  25                  30          


Ala Val Pro Ala Val Trp Phe Ser Ile Glu Leu Ile Phe Gly Leu Phe 
        35                  40                  45              


Ala Leu Lys Asn Gly Pro Glu Ala Trp Ala Gly Phe Val Asp Phe Leu 
    50                  55                  60                  


Gln Asn Pro Val Ile Val Ile Ile Asn Leu Ile Thr Leu Ala Ala Ala 
65                  70                  75                  80  


Leu Leu His Thr Lys Thr Trp Phe Glu Leu Ala Pro Lys Ala Ala Asn 
                85                  90                  95      


Ile Ile Val Lys Asp Glu Lys Met Gly Pro Glu Pro Ile Ile Lys Ser 
            100                 105                 110         


Leu Trp Ala Val Thr Val Val Ala Thr Ile Val Ile Leu Phe Val Ala 
        115                 120                 125             


Leu Tyr Trp 
    130     


<210>  93
<211>  396
<212>  DNA
<213>  Escherichia coli

<400>  93
atgacgacta aacgtaaacc gtatgtacgg ccaatgacgt ccacctggtg gaaaaaattg       60

ccgttttatc gcttttacat gctgcgcgaa ggcacggcgg ttccggctgt gtggttcagc      120

attgaactga ttttcgggct gtttgccctg aaaaatggcc cggaagcctg ggcgggattc      180

gtcgactttt tacaaaaccc ggttatcgtg atcattaacc tgatcactct ggcggcagct      240

ctgctgcaca ccaaaacctg gtttgaactg gcaccgaaag cggccaatat cattgtaaaa      300

gacgaaaaaa tgggaccaga gccaattatc aaaagtctct gggcggtaac tgtggttgcc      360

accatcgtaa tcctgtttgt tgccctgtac tggtaa                                396


<210>  94
<211>  119
<212>  PRT
<213>  Escherichia coli

<400>  94

Met Ile Asn Pro Asn Pro Lys Arg Ser Asp Glu Pro Val Phe Trp Gly 
1               5                   10                  15      


Leu Phe Gly Ala Gly Gly Met Trp Ser Ala Ile Ile Ala Pro Val Met 
            20                  25                  30          


Ile Leu Leu Val Gly Ile Leu Leu Pro Leu Gly Leu Phe Pro Gly Asp 
        35                  40                  45              


Ala Leu Ser Tyr Glu Arg Val Leu Ala Phe Ala Gln Ser Phe Ile Gly 
    50                  55                  60                  


Arg Val Phe Leu Phe Leu Met Ile Val Leu Pro Leu Trp Cys Gly Leu 
65                  70                  75                  80  


His Arg Met His His Ala Met His Asp Leu Lys Ile His Val Pro Ala 
                85                  90                  95      


Gly Lys Trp Val Phe Tyr Gly Leu Ala Ala Ile Leu Thr Val Val Thr 
            100                 105                 110         


Leu Ile Gly Val Val Thr Ile 
        115                 


<210>  95
<211>  360
<212>  DNA
<213>  Escherichia coli

<400>  95
atgattaatc caaatccaaa gcgttctgac gaaccggtat tctggggcct cttcggggcc       60

ggtggtatgt ggagcgccat cattgcgccg gtgatgatcc tgctggtggg tattctgctg      120

ccactggggt tgtttccggg tgatgcgctg agctacgagc gcgttctggc gttcgcgcag      180

agcttcattg gtcgcgtatt cctgttcctg atgatcgttc tgccgctgtg gtgtggttta      240

caccgtatgc accacgcgat gcacgatctg aaaatccacg tacctgcggg caaatgggtt      300

ttctacggtc tggctgctat cctgacagtt gtcacgctga ttggtgtcgt tacaatctaa      360


