                         SEQUENCE LISTING

<110>  AMGEN INC.
 
<120>  ANTI-ORAI1 ANTIGEN BINDING PROTEINS AND USES THEREOF

<130>  A-1466-WO-PCT

<140>  PCT/US XX/XXXXXX
<141>  2010-11-19

<150>  61/263,176
<151>  2009-11-20

<150>  61/406,054
<151>  2010-10-22

<160>  348   

<170>  PatentIn version 3.5

<210>  1
<211>  906
<212>  DNA
<213>  Homo sapiens


<220>
<221>  misc_feature
<223>  ORAI1

<220>
<221>  CDS
<222>  (1)..(903)

<400>  1
atg cat ccg gag ccc gcc ccg ccc ccg agc cgc agc agt ccc gag ctt         48
Met His Pro Glu Pro Ala Pro Pro Pro Ser Arg Ser Ser Pro Glu Leu           
1               5                   10                  15                

ccc cca agc ggc ggc agc acc acc agc ggc agc cgc cgg agc cgc cgc         96
Pro Pro Ser Gly Gly Ser Thr Thr Ser Gly Ser Arg Arg Ser Arg Arg           
            20                  25                  30                    

cgc agc ggg gac ggg gag ccc ccg ggg gcc ccg cca ccg ccg ccg tcc        144
Arg Ser Gly Asp Gly Glu Pro Pro Gly Ala Pro Pro Pro Pro Pro Ser           
        35                  40                  45                        

gcc gtc acc tac ccg gac tgg atc ggc cag agt tac tcc gag gtg atg        192
Ala Val Thr Tyr Pro Asp Trp Ile Gly Gln Ser Tyr Ser Glu Val Met           
    50                  55                  60                            

agc ctc aac gag cac tcc atg cag gcg ctg tcc tgg cgc aag ctc tac        240
Ser Leu Asn Glu His Ser Met Gln Ala Leu Ser Trp Arg Lys Leu Tyr           
65                  70                  75                  80            

ttg agc cgc gcc aag ctt aaa gcc tcc agc cgg acc tcg gct ctg ctc        288
Leu Ser Arg Ala Lys Leu Lys Ala Ser Ser Arg Thr Ser Ala Leu Leu           
                85                  90                  95                

tcc ggc ttc gcc atg gtg gca atg gtg gag gtg cag ctg gac gct gac        336
Ser Gly Phe Ala Met Val Ala Met Val Glu Val Gln Leu Asp Ala Asp           
            100                 105                 110                   

cac gac tac cca ccg ggg ctg ctc atc gcc ttc agt gcc tgc acc aca        384
His Asp Tyr Pro Pro Gly Leu Leu Ile Ala Phe Ser Ala Cys Thr Thr           
        115                 120                 125                       

gtg ctg gtg gct gtg cac ctg ttt gcg ctc atg atc agc acc tgc atc        432
Val Leu Val Ala Val His Leu Phe Ala Leu Met Ile Ser Thr Cys Ile           
    130                 135                 140                           

ctg ccc aac atc gag gcg gtg agc aac gtg cac aat ctc aac tcg gtc        480
Leu Pro Asn Ile Glu Ala Val Ser Asn Val His Asn Leu Asn Ser Val           
145                 150                 155                 160           

aag gag tcc ccc cat gag cgc atg cac cgc cac atc gag ctg gcc tgg        528
Lys Glu Ser Pro His Glu Arg Met His Arg His Ile Glu Leu Ala Trp           
                165                 170                 175               

gcc ttc tcc acc gtc atc ggc acg ctg ctc ttc cta gct gag gtg gtg        576
Ala Phe Ser Thr Val Ile Gly Thr Leu Leu Phe Leu Ala Glu Val Val           
            180                 185                 190                   

ctg ctc tgc tgg gtc aag ttc ttg ccc ctc aag aag cag cca ggc cag        624
Leu Leu Cys Trp Val Lys Phe Leu Pro Leu Lys Lys Gln Pro Gly Gln           
        195                 200                 205                       

cca agg ccc acc agc aag ccc ccc gcc agt ggc gca gca gcc aac gtc        672
Pro Arg Pro Thr Ser Lys Pro Pro Ala Ser Gly Ala Ala Ala Asn Val           
    210                 215                 220                           

agc acc agc ggc atc acc ccg ggc cag gca gct gcc atc gcc tcg acc        720
Ser Thr Ser Gly Ile Thr Pro Gly Gln Ala Ala Ala Ile Ala Ser Thr           
225                 230                 235                 240           

acc atc atg gtg ccc ttc ggc ctg atc ttt atc gtc ttc gcc gtc cac        768
Thr Ile Met Val Pro Phe Gly Leu Ile Phe Ile Val Phe Ala Val His           
                245                 250                 255               

ttc tac cgc tca ctg gtt agc cat aag act gac cga cag ttc cag gag        816
Phe Tyr Arg Ser Leu Val Ser His Lys Thr Asp Arg Gln Phe Gln Glu           
            260                 265                 270                   

ctc aac gag ctg gcg gag ttt gcc cgc tta cag gac cag ctg gac cac        864
Leu Asn Glu Leu Ala Glu Phe Ala Arg Leu Gln Asp Gln Leu Asp His           
        275                 280                 285                       

aga ggg gac cac ccc ctg acg ccc ggc agc cac tat gcc tag                906
Arg Gly Asp His Pro Leu Thr Pro Gly Ser His Tyr Ala                       
    290                 295                 300                           


<210>  2
<211>  301
<212>  PRT
<213>  Homo sapiens

<400>  2

Met His Pro Glu Pro Ala Pro Pro Pro Ser Arg Ser Ser Pro Glu Leu 
1               5                   10                  15      


Pro Pro Ser Gly Gly Ser Thr Thr Ser Gly Ser Arg Arg Ser Arg Arg 
            20                  25                  30          


Arg Ser Gly Asp Gly Glu Pro Pro Gly Ala Pro Pro Pro Pro Pro Ser 
        35                  40                  45              


Ala Val Thr Tyr Pro Asp Trp Ile Gly Gln Ser Tyr Ser Glu Val Met 
    50                  55                  60                  


Ser Leu Asn Glu His Ser Met Gln Ala Leu Ser Trp Arg Lys Leu Tyr 
65                  70                  75                  80  


Leu Ser Arg Ala Lys Leu Lys Ala Ser Ser Arg Thr Ser Ala Leu Leu 
                85                  90                  95      


Ser Gly Phe Ala Met Val Ala Met Val Glu Val Gln Leu Asp Ala Asp 
            100                 105                 110         


His Asp Tyr Pro Pro Gly Leu Leu Ile Ala Phe Ser Ala Cys Thr Thr 
        115                 120                 125             


Val Leu Val Ala Val His Leu Phe Ala Leu Met Ile Ser Thr Cys Ile 
    130                 135                 140                 


Leu Pro Asn Ile Glu Ala Val Ser Asn Val His Asn Leu Asn Ser Val 
145                 150                 155                 160 


Lys Glu Ser Pro His Glu Arg Met His Arg His Ile Glu Leu Ala Trp 
                165                 170                 175     


Ala Phe Ser Thr Val Ile Gly Thr Leu Leu Phe Leu Ala Glu Val Val 
            180                 185                 190         


Leu Leu Cys Trp Val Lys Phe Leu Pro Leu Lys Lys Gln Pro Gly Gln 
        195                 200                 205             


Pro Arg Pro Thr Ser Lys Pro Pro Ala Ser Gly Ala Ala Ala Asn Val 
    210                 215                 220                 


Ser Thr Ser Gly Ile Thr Pro Gly Gln Ala Ala Ala Ile Ala Ser Thr 
225                 230                 235                 240 


Thr Ile Met Val Pro Phe Gly Leu Ile Phe Ile Val Phe Ala Val His 
                245                 250                 255     


Phe Tyr Arg Ser Leu Val Ser His Lys Thr Asp Arg Gln Phe Gln Glu 
            260                 265                 270         


Leu Asn Glu Leu Ala Glu Phe Ala Arg Leu Gln Asp Gln Leu Asp His 
        275                 280                 285             


Arg Gly Asp His Pro Leu Thr Pro Gly Ser His Tyr Ala 
    290                 295                 300     


<210>  3
<211>  8
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<223>  Putative ORAI1 ECL1 domain sequence

<400>  3

Asp Ala Asp His Asp Tyr Pro Pro 
1               5               


<210>  4
<211>  36
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<223>  Putative ORAI1 ECL2 domain sequence

<400>  4

Lys Phe Leu Pro Leu Lys Lys Gln Pro Gly Gln Pro Arg Pro Thr Ser 
1               5                   10                  15      


Lys Pro Pro Ala Ser Gly Ala Ala Ala Asn Val Ser Thr Ser Gly Ile 
            20                  25                  30          


Thr Pro Gly Gln 
        35      


<210>  5
<211>  2058
<212>  DNA
<213>  Homo sapiens


<220>
<221>  misc_feature
<223>  STIM1

<220>
<221>  CDS
<222>  (1)..(2055)

<400>  5
atg gat gta tgc gtc cgt ctt gcc ctg tgg ctc ctc tgg gga ctc ctc         48
Met Asp Val Cys Val Arg Leu Ala Leu Trp Leu Leu Trp Gly Leu Leu           
1               5                   10                  15                

ctg cac cag ggc cag agc ctc agc cat agt cac agt gag aag gcg aca         96
Leu His Gln Gly Gln Ser Leu Ser His Ser His Ser Glu Lys Ala Thr           
            20                  25                  30                    

gga acc agc tcg ggg gcc aac tct gag gag tcc act gca gca gag ttt        144
Gly Thr Ser Ser Gly Ala Asn Ser Glu Glu Ser Thr Ala Ala Glu Phe           
        35                  40                  45                        

tgc cga att gac aag ccc ctg tgt cac agt gag gat gag aaa ctc agc        192
Cys Arg Ile Asp Lys Pro Leu Cys His Ser Glu Asp Glu Lys Leu Ser           
    50                  55                  60                            

ttc gag gca gtc cgt aac atc cac aaa ctg atg gac gat gat gcc aat        240
Phe Glu Ala Val Arg Asn Ile His Lys Leu Met Asp Asp Asp Ala Asn           
65                  70                  75                  80            

ggt gat gtg gat gtg gaa gaa agt gat gag ttc ctg agg gaa gac ctc        288
Gly Asp Val Asp Val Glu Glu Ser Asp Glu Phe Leu Arg Glu Asp Leu           
                85                  90                  95                

aat tac cat gac cca aca gtg aaa cac agc acc ttc cat ggt gag gat        336
Asn Tyr His Asp Pro Thr Val Lys His Ser Thr Phe His Gly Glu Asp           
            100                 105                 110                   

aag ctc atc agc gtg gag gac ctg tgg aag gca tgg aag tca tca gaa        384
Lys Leu Ile Ser Val Glu Asp Leu Trp Lys Ala Trp Lys Ser Ser Glu           
        115                 120                 125                       

gta tac aat tgg acc gtg gat gag gtg gta cag tgg ctg atc aca tat        432
Val Tyr Asn Trp Thr Val Asp Glu Val Val Gln Trp Leu Ile Thr Tyr           
    130                 135                 140                           

gtg gag ctg cct cag tat gag gag acc ttc cgg aag ctg cag ctc agt        480
Val Glu Leu Pro Gln Tyr Glu Glu Thr Phe Arg Lys Leu Gln Leu Ser           
145                 150                 155                 160           

ggc cat gcc atg cca agg ctg gct gtc acc aac acc acc atg aca ggg        528
Gly His Ala Met Pro Arg Leu Ala Val Thr Asn Thr Thr Met Thr Gly           
                165                 170                 175               

act gtg ctg aag atg aca gac cgg agt cat cgg cag aag ctg cag ctg        576
Thr Val Leu Lys Met Thr Asp Arg Ser His Arg Gln Lys Leu Gln Leu           
            180                 185                 190                   

aag gct ctg gat aca gtg ctc ttt ggg cct cct ctc ttg act cgc cat        624
Lys Ala Leu Asp Thr Val Leu Phe Gly Pro Pro Leu Leu Thr Arg His           
        195                 200                 205                       

aat cac ctc aag gac ttc atg ctg gtg gtg tct atc gtt att ggt gtg        672
Asn His Leu Lys Asp Phe Met Leu Val Val Ser Ile Val Ile Gly Val           
    210                 215                 220                           

ggc ggc tgc tgg ttt gcc tat atc cag aac cgt tac tcc aag gag cac        720
Gly Gly Cys Trp Phe Ala Tyr Ile Gln Asn Arg Tyr Ser Lys Glu His           
225                 230                 235                 240           

atg aag aag atg atg aag gac ttg gag ggg tta cac cga gct gag cag        768
Met Lys Lys Met Met Lys Asp Leu Glu Gly Leu His Arg Ala Glu Gln           
                245                 250                 255               

agt ctg cat gac ctt cag gaa agg ctg cac aag gcc cag gag gag cac        816
Ser Leu His Asp Leu Gln Glu Arg Leu His Lys Ala Gln Glu Glu His           
            260                 265                 270                   

cgc aca gtg gag gtg gag aag gtc cat ctg gaa aag aag ctg cgc gat        864
Arg Thr Val Glu Val Glu Lys Val His Leu Glu Lys Lys Leu Arg Asp           
        275                 280                 285                       

gag atc aac ctt gct aag cag gaa gcc cag cgg ctg aag gag ctg cgg        912
Glu Ile Asn Leu Ala Lys Gln Glu Ala Gln Arg Leu Lys Glu Leu Arg           
    290                 295                 300                           

gag ggt act gag aat gag cgg agc cgc caa aaa tat gct gag gag gag        960
Glu Gly Thr Glu Asn Glu Arg Ser Arg Gln Lys Tyr Ala Glu Glu Glu           
305                 310                 315                 320           

ttg gag cag gtt cgg gag gcc ttg agg aaa gca gag aag gag cta gaa       1008
Leu Glu Gln Val Arg Glu Ala Leu Arg Lys Ala Glu Lys Glu Leu Glu           
                325                 330                 335               

tct cac agc tca tgg tat gct cca gag gcc ctt cag aag tgg ctg cag       1056
Ser His Ser Ser Trp Tyr Ala Pro Glu Ala Leu Gln Lys Trp Leu Gln           
            340                 345                 350                   

ctg aca cat gag gtg gag gtg caa tat tac aac atc aag aag caa aat       1104
Leu Thr His Glu Val Glu Val Gln Tyr Tyr Asn Ile Lys Lys Gln Asn           
        355                 360                 365                       

gct gag aag cag ctg ctg gtg gcc aag gag ggg gct gag aag ata aaa       1152
Ala Glu Lys Gln Leu Leu Val Ala Lys Glu Gly Ala Glu Lys Ile Lys           
    370                 375                 380                           

aag aag aga aac aca ctc ttt ggc acc ttc cac gtg gcc cac agc tct       1200
Lys Lys Arg Asn Thr Leu Phe Gly Thr Phe His Val Ala His Ser Ser           
385                 390                 395                 400           

tcc ctg gat gat gta gat cat aaa att cta aca gct aag caa gca ctg       1248
Ser Leu Asp Asp Val Asp His Lys Ile Leu Thr Ala Lys Gln Ala Leu           
                405                 410                 415               

agc gag gtg aca gca gca ttg cgg gag cgc ctg cac cgc tgg caa cag       1296
Ser Glu Val Thr Ala Ala Leu Arg Glu Arg Leu His Arg Trp Gln Gln           
            420                 425                 430                   

atc gag atc ctc tgt ggc ttc cag att gtc aac aac cct ggc atc cac       1344
Ile Glu Ile Leu Cys Gly Phe Gln Ile Val Asn Asn Pro Gly Ile His           
        435                 440                 445                       

tca ctg gtg gct gcc ctc aac ata gac ccc agc tgg atg ggc agt aca       1392
Ser Leu Val Ala Ala Leu Asn Ile Asp Pro Ser Trp Met Gly Ser Thr           
    450                 455                 460                           

cgc ccc aac cct gct cac ttc atc atg act gac gac gtg gat gac atg       1440
Arg Pro Asn Pro Ala His Phe Ile Met Thr Asp Asp Val Asp Asp Met           
465                 470                 475                 480           

gat gag gag att gtg tct ccc ttg tcc atg cag tcc cct agc ctg cag       1488
Asp Glu Glu Ile Val Ser Pro Leu Ser Met Gln Ser Pro Ser Leu Gln           
                485                 490                 495               

agc agt gtt cgg cag cgc ctg acg gag cca cag cat ggc ctg gga tct       1536
Ser Ser Val Arg Gln Arg Leu Thr Glu Pro Gln His Gly Leu Gly Ser           
            500                 505                 510                   

cag agg gat ttg acc cat tcc gat tcg gag tcc tcc ctc cac atg agt       1584
Gln Arg Asp Leu Thr His Ser Asp Ser Glu Ser Ser Leu His Met Ser           
        515                 520                 525                       

gac cgc cag cgt gtg gcc ccc aaa cct cct cag atg agc cgt gct gca       1632
Asp Arg Gln Arg Val Ala Pro Lys Pro Pro Gln Met Ser Arg Ala Ala           
    530                 535                 540                           

gac gag gct ctc aat gcc atg act tcc aat ggc agc cac cgg ctg atc       1680
Asp Glu Ala Leu Asn Ala Met Thr Ser Asn Gly Ser His Arg Leu Ile           
545                 550                 555                 560           

gag ggg gtc cac cca ggg tct ctg gtg gag aaa ctg cct gac agc cct       1728
Glu Gly Val His Pro Gly Ser Leu Val Glu Lys Leu Pro Asp Ser Pro           
                565                 570                 575               

gcc ctg gcc aag aag gca tta ctg gcg ctg aac cat ggg ctg gac aag       1776
Ala Leu Ala Lys Lys Ala Leu Leu Ala Leu Asn His Gly Leu Asp Lys           
            580                 585                 590                   

gcc cac agc ctg atg gag ctg agc ccc tca gcc cca cct ggt ggc tct       1824
Ala His Ser Leu Met Glu Leu Ser Pro Ser Ala Pro Pro Gly Gly Ser           
        595                 600                 605                       

cca cat ttg gat tct tcc cgt tct cac agc ccc agc tcc cca gac cca       1872
Pro His Leu Asp Ser Ser Arg Ser His Ser Pro Ser Ser Pro Asp Pro           
    610                 615                 620                           

gac aca cca tct cca gtt ggg gac agc cga gcc ctg caa gcc agc cga       1920
Asp Thr Pro Ser Pro Val Gly Asp Ser Arg Ala Leu Gln Ala Ser Arg           
625                 630                 635                 640           

aac aca cgc att ccc cac ctg gct ggc aag aag gct gtg gct gag gag       1968
Asn Thr Arg Ile Pro His Leu Ala Gly Lys Lys Ala Val Ala Glu Glu           
                645                 650                 655               

gat aat ggc tct att ggc gag gaa aca gac tcc agc cca ggc cgg aag       2016
Asp Asn Gly Ser Ile Gly Glu Glu Thr Asp Ser Ser Pro Gly Arg Lys           
            660                 665                 670                   

aag ttt ccc ctc aaa atc ttt aag aag cct ctt aag aag tag               2058
Lys Phe Pro Leu Lys Ile Phe Lys Lys Pro Leu Lys Lys                       
        675                 680                 685                       


<210>  6
<211>  685
<212>  PRT
<213>  Homo sapiens

<400>  6

Met Asp Val Cys Val Arg Leu Ala Leu Trp Leu Leu Trp Gly Leu Leu 
1               5                   10                  15      


Leu His Gln Gly Gln Ser Leu Ser His Ser His Ser Glu Lys Ala Thr 
            20                  25                  30          


Gly Thr Ser Ser Gly Ala Asn Ser Glu Glu Ser Thr Ala Ala Glu Phe 
        35                  40                  45              


Cys Arg Ile Asp Lys Pro Leu Cys His Ser Glu Asp Glu Lys Leu Ser 
    50                  55                  60                  


Phe Glu Ala Val Arg Asn Ile His Lys Leu Met Asp Asp Asp Ala Asn 
65                  70                  75                  80  


Gly Asp Val Asp Val Glu Glu Ser Asp Glu Phe Leu Arg Glu Asp Leu 
                85                  90                  95      


Asn Tyr His Asp Pro Thr Val Lys His Ser Thr Phe His Gly Glu Asp 
            100                 105                 110         


Lys Leu Ile Ser Val Glu Asp Leu Trp Lys Ala Trp Lys Ser Ser Glu 
        115                 120                 125             


Val Tyr Asn Trp Thr Val Asp Glu Val Val Gln Trp Leu Ile Thr Tyr 
    130                 135                 140                 


Val Glu Leu Pro Gln Tyr Glu Glu Thr Phe Arg Lys Leu Gln Leu Ser 
145                 150                 155                 160 


Gly His Ala Met Pro Arg Leu Ala Val Thr Asn Thr Thr Met Thr Gly 
                165                 170                 175     


Thr Val Leu Lys Met Thr Asp Arg Ser His Arg Gln Lys Leu Gln Leu 
            180                 185                 190         


Lys Ala Leu Asp Thr Val Leu Phe Gly Pro Pro Leu Leu Thr Arg His 
        195                 200                 205             


Asn His Leu Lys Asp Phe Met Leu Val Val Ser Ile Val Ile Gly Val 
    210                 215                 220                 


Gly Gly Cys Trp Phe Ala Tyr Ile Gln Asn Arg Tyr Ser Lys Glu His 
225                 230                 235                 240 


Met Lys Lys Met Met Lys Asp Leu Glu Gly Leu His Arg Ala Glu Gln 
                245                 250                 255     


Ser Leu His Asp Leu Gln Glu Arg Leu His Lys Ala Gln Glu Glu His 
            260                 265                 270         


Arg Thr Val Glu Val Glu Lys Val His Leu Glu Lys Lys Leu Arg Asp 
        275                 280                 285             


Glu Ile Asn Leu Ala Lys Gln Glu Ala Gln Arg Leu Lys Glu Leu Arg 
    290                 295                 300                 


Glu Gly Thr Glu Asn Glu Arg Ser Arg Gln Lys Tyr Ala Glu Glu Glu 
305                 310                 315                 320 


Leu Glu Gln Val Arg Glu Ala Leu Arg Lys Ala Glu Lys Glu Leu Glu 
                325                 330                 335     


Ser His Ser Ser Trp Tyr Ala Pro Glu Ala Leu Gln Lys Trp Leu Gln 
            340                 345                 350         


Leu Thr His Glu Val Glu Val Gln Tyr Tyr Asn Ile Lys Lys Gln Asn 
        355                 360                 365             


Ala Glu Lys Gln Leu Leu Val Ala Lys Glu Gly Ala Glu Lys Ile Lys 
    370                 375                 380                 


Lys Lys Arg Asn Thr Leu Phe Gly Thr Phe His Val Ala His Ser Ser 
385                 390                 395                 400 


Ser Leu Asp Asp Val Asp His Lys Ile Leu Thr Ala Lys Gln Ala Leu 
                405                 410                 415     


Ser Glu Val Thr Ala Ala Leu Arg Glu Arg Leu His Arg Trp Gln Gln 
            420                 425                 430         


Ile Glu Ile Leu Cys Gly Phe Gln Ile Val Asn Asn Pro Gly Ile His 
        435                 440                 445             


Ser Leu Val Ala Ala Leu Asn Ile Asp Pro Ser Trp Met Gly Ser Thr 
    450                 455                 460                 


Arg Pro Asn Pro Ala His Phe Ile Met Thr Asp Asp Val Asp Asp Met 
465                 470                 475                 480 


Asp Glu Glu Ile Val Ser Pro Leu Ser Met Gln Ser Pro Ser Leu Gln 
                485                 490                 495     


Ser Ser Val Arg Gln Arg Leu Thr Glu Pro Gln His Gly Leu Gly Ser 
            500                 505                 510         


Gln Arg Asp Leu Thr His Ser Asp Ser Glu Ser Ser Leu His Met Ser 
        515                 520                 525             


Asp Arg Gln Arg Val Ala Pro Lys Pro Pro Gln Met Ser Arg Ala Ala 
    530                 535                 540                 


Asp Glu Ala Leu Asn Ala Met Thr Ser Asn Gly Ser His Arg Leu Ile 
545                 550                 555                 560 


Glu Gly Val His Pro Gly Ser Leu Val Glu Lys Leu Pro Asp Ser Pro 
                565                 570                 575     


Ala Leu Ala Lys Lys Ala Leu Leu Ala Leu Asn His Gly Leu Asp Lys 
            580                 585                 590         


Ala His Ser Leu Met Glu Leu Ser Pro Ser Ala Pro Pro Gly Gly Ser 
        595                 600                 605             


Pro His Leu Asp Ser Ser Arg Ser His Ser Pro Ser Ser Pro Asp Pro 
    610                 615                 620                 


Asp Thr Pro Ser Pro Val Gly Asp Ser Arg Ala Leu Gln Ala Ser Arg 
625                 630                 635                 640 


Asn Thr Arg Ile Pro His Leu Ala Gly Lys Lys Ala Val Ala Glu Glu 
                645                 650                 655     


Asp Asn Gly Ser Ile Gly Glu Glu Thr Asp Ser Ser Pro Gly Arg Lys 
            660                 665                 670         


Lys Phe Pro Leu Lys Ile Phe Lys Lys Pro Leu Lys Lys 
        675                 680                 685 


<210>  7
<211>  720
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Yellow fluorescent protein coding sequence


<220>
<221>  CDS
<222>  (1)..(717)

<400>  7
atg gtg agc aag ggc gag gag ctg ttc acc ggg gtg gtg ccc atc ctg         48
Met Val Ser Lys Gly Glu Glu Leu Phe Thr Gly Val Val Pro Ile Leu           
1               5                   10                  15                

gtc gag ctg gac ggc gac gta aac ggc cac aag ttc agc gtg tcc ggc         96
Val Glu Leu Asp Gly Asp Val Asn Gly His Lys Phe Ser Val Ser Gly           
            20                  25                  30                    

gag ggc gag ggc gat gcc acc tac ggc aag ctg acc ctg aag ttc atc        144
Glu Gly Glu Gly Asp Ala Thr Tyr Gly Lys Leu Thr Leu Lys Phe Ile           
        35                  40                  45                        

tgc acc acc ggc aag ctg ccc gtg ccc tgg ccc acc ctc gtg acc acc        192
Cys Thr Thr Gly Lys Leu Pro Val Pro Trp Pro Thr Leu Val Thr Thr           
    50                  55                  60                            

ttc ggc tac ggc gtg cag tgc ttc gcc cgc tac ccc gac cac atg cgc        240
Phe Gly Tyr Gly Val Gln Cys Phe Ala Arg Tyr Pro Asp His Met Arg           
65                  70                  75                  80            

cag cac gac ttc ttc aag tcc gcc atg ccc gaa ggc tac gtc cag gag        288
Gln His Asp Phe Phe Lys Ser Ala Met Pro Glu Gly Tyr Val Gln Glu           
                85                  90                  95                

cgc acc atc ttc ttc aag gac gac ggc aac tac aag acc cgc gcc gag        336
Arg Thr Ile Phe Phe Lys Asp Asp Gly Asn Tyr Lys Thr Arg Ala Glu           
            100                 105                 110                   

gtg aag ttc gag ggc gac acc ctg gtg aac cgc atc gag ctg aag ggc        384
Val Lys Phe Glu Gly Asp Thr Leu Val Asn Arg Ile Glu Leu Lys Gly           
        115                 120                 125                       

atc gac ttc aag gag gac ggc aac atc ctg ggg cac aag ctg gag tac        432
Ile Asp Phe Lys Glu Asp Gly Asn Ile Leu Gly His Lys Leu Glu Tyr           
    130                 135                 140                           

aac tac aac agc cac aac gtc tat atc atg gcc gac aag cag aag aac        480
Asn Tyr Asn Ser His Asn Val Tyr Ile Met Ala Asp Lys Gln Lys Asn           
145                 150                 155                 160           

ggc atc aag gtg aac ttc aag atc cgc cac aac atc gag gac ggc agc        528
Gly Ile Lys Val Asn Phe Lys Ile Arg His Asn Ile Glu Asp Gly Ser           
                165                 170                 175               

gtg cag ctc gcc gac cac tac cag cag aac acc ccc atc ggc gac ggc        576
Val Gln Leu Ala Asp His Tyr Gln Gln Asn Thr Pro Ile Gly Asp Gly           
            180                 185                 190                   

ccc gtg ctg ctg ccc gac aac cac tac ctg agc tac cag tcc gcc ctg        624
Pro Val Leu Leu Pro Asp Asn His Tyr Leu Ser Tyr Gln Ser Ala Leu           
        195                 200                 205                       

agc aaa gac ccc aac gag aag cgc gat cac atg gtc ctg ctg gag ttc        672
Ser Lys Asp Pro Asn Glu Lys Arg Asp His Met Val Leu Leu Glu Phe           
    210                 215                 220                           

gtg acc gcc gcc ggg atc act ctc ggc atg gac gag ctg tac aag tag        720
Val Thr Ala Ala Gly Ile Thr Leu Gly Met Asp Glu Leu Tyr Lys               
225                 230                 235                               


<210>  8
<211>  239
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  8

Met Val Ser Lys Gly Glu Glu Leu Phe Thr Gly Val Val Pro Ile Leu 
1               5                   10                  15      


Val Glu Leu Asp Gly Asp Val Asn Gly His Lys Phe Ser Val Ser Gly 
            20                  25                  30          


Glu Gly Glu Gly Asp Ala Thr Tyr Gly Lys Leu Thr Leu Lys Phe Ile 
        35                  40                  45              


Cys Thr Thr Gly Lys Leu Pro Val Pro Trp Pro Thr Leu Val Thr Thr 
    50                  55                  60                  


Phe Gly Tyr Gly Val Gln Cys Phe Ala Arg Tyr Pro Asp His Met Arg 
65                  70                  75                  80  


Gln His Asp Phe Phe Lys Ser Ala Met Pro Glu Gly Tyr Val Gln Glu 
                85                  90                  95      


Arg Thr Ile Phe Phe Lys Asp Asp Gly Asn Tyr Lys Thr Arg Ala Glu 
            100                 105                 110         


Val Lys Phe Glu Gly Asp Thr Leu Val Asn Arg Ile Glu Leu Lys Gly 
        115                 120                 125             


Ile Asp Phe Lys Glu Asp Gly Asn Ile Leu Gly His Lys Leu Glu Tyr 
    130                 135                 140                 


Asn Tyr Asn Ser His Asn Val Tyr Ile Met Ala Asp Lys Gln Lys Asn 
145                 150                 155                 160 


Gly Ile Lys Val Asn Phe Lys Ile Arg His Asn Ile Glu Asp Gly Ser 
                165                 170                 175     


Val Gln Leu Ala Asp His Tyr Gln Gln Asn Thr Pro Ile Gly Asp Gly 
            180                 185                 190         


Pro Val Leu Leu Pro Asp Asn His Tyr Leu Ser Tyr Gln Ser Ala Leu 
        195                 200                 205             


Ser Lys Asp Pro Asn Glu Lys Arg Asp His Met Val Leu Leu Glu Phe 
    210                 215                 220                 


Val Thr Ala Ala Gly Ile Thr Leu Gly Met Asp Glu Leu Tyr Lys 
225                 230                 235                 


<210>  9
<211>  2775
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  hSTIM1 yellow fluorescent protein coding sequence


<220>
<221>  CDS
<222>  (1)..(2772)

<400>  9
atg gat gta tgc gtc cgt ctt gcc ctg tgg ctc ctc tgg gga ctc ctc         48
Met Asp Val Cys Val Arg Leu Ala Leu Trp Leu Leu Trp Gly Leu Leu           
1               5                   10                  15                

ctg cac cag ggc cag agc ctc agc cat agt cac agt gag aag gcg aca         96
Leu His Gln Gly Gln Ser Leu Ser His Ser His Ser Glu Lys Ala Thr           
            20                  25                  30                    

gga acc agc tcg gga gcc aac atg gtg agc aag ggc gag gag ctg ttc        144
Gly Thr Ser Ser Gly Ala Asn Met Val Ser Lys Gly Glu Glu Leu Phe           
        35                  40                  45                        

acc ggg gtg gtg ccc atc ctg gtc gag ctg gac ggc gac gta aac ggc        192
Thr Gly Val Val Pro Ile Leu Val Glu Leu Asp Gly Asp Val Asn Gly           
    50                  55                  60                            

cac aag ttc agc gtg tcc ggc gag ggc gag ggc gat gcc acc tac ggc        240
His Lys Phe Ser Val Ser Gly Glu Gly Glu Gly Asp Ala Thr Tyr Gly           
65                  70                  75                  80            

aag ctg acc ctg aag ttc atc tgc acc acc ggc aag ctg ccc gtg ccc        288
Lys Leu Thr Leu Lys Phe Ile Cys Thr Thr Gly Lys Leu Pro Val Pro           
                85                  90                  95                

tgg ccc acc ctc gtg acc acc ttc ggc tac ggc gtg cag tgc ttc gcc        336
Trp Pro Thr Leu Val Thr Thr Phe Gly Tyr Gly Val Gln Cys Phe Ala           
            100                 105                 110                   

cgc tac ccc gac cac atg cgc cag cac gac ttc ttc aag tcc gcc atg        384
Arg Tyr Pro Asp His Met Arg Gln His Asp Phe Phe Lys Ser Ala Met           
        115                 120                 125                       

ccc gaa ggc tac gtc cag gag cgc acc atc ttc ttc aag gac gac ggc        432
Pro Glu Gly Tyr Val Gln Glu Arg Thr Ile Phe Phe Lys Asp Asp Gly           
    130                 135                 140                           

aac tac aag acc cgc gcc gag gtg aag ttc gag ggc gac acc ctg gtg        480
Asn Tyr Lys Thr Arg Ala Glu Val Lys Phe Glu Gly Asp Thr Leu Val           
145                 150                 155                 160           

aac cgc atc gag ctg aag ggc atc gac ttc aag gag gac ggc aac atc        528
Asn Arg Ile Glu Leu Lys Gly Ile Asp Phe Lys Glu Asp Gly Asn Ile           
                165                 170                 175               

ctg ggg cac aag ctg gag tac aac tac aac agc cac aac gtc tat atc        576
Leu Gly His Lys Leu Glu Tyr Asn Tyr Asn Ser His Asn Val Tyr Ile           
            180                 185                 190                   

atg gcc gac aag cag aag aac ggc atc aag gtg aac ttc aag atc cgc        624
Met Ala Asp Lys Gln Lys Asn Gly Ile Lys Val Asn Phe Lys Ile Arg           
        195                 200                 205                       

cac aac atc gag gac ggc agc gtg cag ctc gcc gac cac tac cag cag        672
His Asn Ile Glu Asp Gly Ser Val Gln Leu Ala Asp His Tyr Gln Gln           
    210                 215                 220                           

aac acc ccc atc ggc gac ggc ccc gtg ctg ctg ccc gac aac cac tac        720
Asn Thr Pro Ile Gly Asp Gly Pro Val Leu Leu Pro Asp Asn His Tyr           
225                 230                 235                 240           

ctg agc tac cag tcc gcc ctg agc aaa gac ccc aac gag aag cgc gat        768
Leu Ser Tyr Gln Ser Ala Leu Ser Lys Asp Pro Asn Glu Lys Arg Asp           
                245                 250                 255               

cac atg gtc ctg ctg gag ttc gtg acc gcc gcc ggg atc act ctc ggc        816
His Met Val Leu Leu Glu Phe Val Thr Ala Ala Gly Ile Thr Leu Gly           
            260                 265                 270                   

atg gac gag ctg tac aag tct gag gag tcg act gca gca gag ttt tgc        864
Met Asp Glu Leu Tyr Lys Ser Glu Glu Ser Thr Ala Ala Glu Phe Cys           
        275                 280                 285                       

cga att gac aag ccc ctg tgt cac agt gag gat gag aaa ctc agc ttc        912
Arg Ile Asp Lys Pro Leu Cys His Ser Glu Asp Glu Lys Leu Ser Phe           
    290                 295                 300                           

gag gca gtc cgt aac atc cac aaa ctg atg gac gat gat gcc aat ggt        960
Glu Ala Val Arg Asn Ile His Lys Leu Met Asp Asp Asp Ala Asn Gly           
305                 310                 315                 320           

gat gtg gat gtg gaa gaa agt gat gag ttc ctg agg gaa gac ctc aat       1008
Asp Val Asp Val Glu Glu Ser Asp Glu Phe Leu Arg Glu Asp Leu Asn           
                325                 330                 335               

tac cat gac cca aca gtg aaa cac agc acc ttc cat ggt gag gat aag       1056
Tyr His Asp Pro Thr Val Lys His Ser Thr Phe His Gly Glu Asp Lys           
            340                 345                 350                   

ctc atc agc gtg gag gac ctg tgg aag gca tgg aag tca tca gaa gta       1104
Leu Ile Ser Val Glu Asp Leu Trp Lys Ala Trp Lys Ser Ser Glu Val           
        355                 360                 365                       

tac aat tgg acc gtg gat gag gtg gta cag tgg ctg atc aca tat gtg       1152
Tyr Asn Trp Thr Val Asp Glu Val Val Gln Trp Leu Ile Thr Tyr Val           
    370                 375                 380                           

gag ctg cct cag tat gag gag acc ttc cgg aag ctg cag ctc agt ggc       1200
Glu Leu Pro Gln Tyr Glu Glu Thr Phe Arg Lys Leu Gln Leu Ser Gly           
385                 390                 395                 400           

cat gcc atg cca agg ctg gct gtc acc aac acc acc atg aca ggg act       1248
His Ala Met Pro Arg Leu Ala Val Thr Asn Thr Thr Met Thr Gly Thr           
                405                 410                 415               

gtg ctg aag atg aca gac cgg agt cat cgg cag aag ctg cag ctg aag       1296
Val Leu Lys Met Thr Asp Arg Ser His Arg Gln Lys Leu Gln Leu Lys           
            420                 425                 430                   

gct ctg gat aca gtg ctc ttt ggg cct cct ctc ttg act cgc cat aat       1344
Ala Leu Asp Thr Val Leu Phe Gly Pro Pro Leu Leu Thr Arg His Asn           
        435                 440                 445                       

cac ctc aag gac ttc atg ctg gtg gtg tct atc gtt att ggt gtg ggc       1392
His Leu Lys Asp Phe Met Leu Val Val Ser Ile Val Ile Gly Val Gly           
    450                 455                 460                           

ggc tgc tgg ttt gcc tat atc cag aac cgt tac tcc aag gag cac atg       1440
Gly Cys Trp Phe Ala Tyr Ile Gln Asn Arg Tyr Ser Lys Glu His Met           
465                 470                 475                 480           

aag aag atg atg aag gac ttg gag ggg tta cac cga gct gag cag agt       1488
Lys Lys Met Met Lys Asp Leu Glu Gly Leu His Arg Ala Glu Gln Ser           
                485                 490                 495               

ctg cat gac ctt cag gaa agg ctg cac aag gcc cag gag gag cac cgc       1536
Leu His Asp Leu Gln Glu Arg Leu His Lys Ala Gln Glu Glu His Arg           
            500                 505                 510                   

aca gtg gag gtg gag aag gtc cat ctg gaa aag aag ctg cgc gat gag       1584
Thr Val Glu Val Glu Lys Val His Leu Glu Lys Lys Leu Arg Asp Glu           
        515                 520                 525                       

atc aac ctt gct aag cag gaa gcc cag cgg ctg aag gag ctg cgg gag       1632
Ile Asn Leu Ala Lys Gln Glu Ala Gln Arg Leu Lys Glu Leu Arg Glu           
    530                 535                 540                           

ggt act gag aat gag cgg agc cgc caa aaa tat gct gag gag gag ttg       1680
Gly Thr Glu Asn Glu Arg Ser Arg Gln Lys Tyr Ala Glu Glu Glu Leu           
545                 550                 555                 560           

gag cag gtt cgg gag gcc ttg agg aaa gca gag aag gag cta gaa tct       1728
Glu Gln Val Arg Glu Ala Leu Arg Lys Ala Glu Lys Glu Leu Glu Ser           
                565                 570                 575               

cac agc tca tgg tat gct cca gag gcc ctt cag aag tgg ctg cag ctg       1776
His Ser Ser Trp Tyr Ala Pro Glu Ala Leu Gln Lys Trp Leu Gln Leu           
            580                 585                 590                   

aca cat gag gtg gag gtg caa tat tac aac atc aag aag caa aat gct       1824
Thr His Glu Val Glu Val Gln Tyr Tyr Asn Ile Lys Lys Gln Asn Ala           
        595                 600                 605                       

gag aag cag ctg ctg gtg gcc aag gag ggg gct gag aag ata aaa aag       1872
Glu Lys Gln Leu Leu Val Ala Lys Glu Gly Ala Glu Lys Ile Lys Lys           
    610                 615                 620                           

aag aga aac aca ctc ttt ggc acc ttc cac gtg gcc cac agc tct tcc       1920
Lys Arg Asn Thr Leu Phe Gly Thr Phe His Val Ala His Ser Ser Ser           
625                 630                 635                 640           

ctg gat gat gta gat cat aaa att cta aca gct aag caa gca ctg agc       1968
Leu Asp Asp Val Asp His Lys Ile Leu Thr Ala Lys Gln Ala Leu Ser           
                645                 650                 655               

gag gtg aca gca gca ttg cgg gag cgc ctg cac cgc tgg caa cag atc       2016
Glu Val Thr Ala Ala Leu Arg Glu Arg Leu His Arg Trp Gln Gln Ile           
            660                 665                 670                   

gag atc ctc tgt ggc ttc cag att gtc aac aac cct ggc atc cac tca       2064
Glu Ile Leu Cys Gly Phe Gln Ile Val Asn Asn Pro Gly Ile His Ser           
        675                 680                 685                       

ctg gtg gct gcc ctc aac ata gac ccc agc tgg atg ggc agt aca cgc       2112
Leu Val Ala Ala Leu Asn Ile Asp Pro Ser Trp Met Gly Ser Thr Arg           
    690                 695                 700                           

ccc aac cct gct cac ttc atc atg act gac gac gtg gat gac atg gat       2160
Pro Asn Pro Ala His Phe Ile Met Thr Asp Asp Val Asp Asp Met Asp           
705                 710                 715                 720           

gag gag att gtg tct ccc ttg tcc atg cag tcc cct agc ctg cag agc       2208
Glu Glu Ile Val Ser Pro Leu Ser Met Gln Ser Pro Ser Leu Gln Ser           
                725                 730                 735               

agt gtt cgg cag cgc ctg acg gag cca cag cat ggc ctg gga tct cag       2256
Ser Val Arg Gln Arg Leu Thr Glu Pro Gln His Gly Leu Gly Ser Gln           
            740                 745                 750                   

agg gat ttg acc cat tcc gat tcg gag tcc tcc ctc cac atg agt gac       2304
Arg Asp Leu Thr His Ser Asp Ser Glu Ser Ser Leu His Met Ser Asp           
        755                 760                 765                       

cgc cag cgt gtg gcc ccc aaa cct cct cag atg agc cgt gct gca gac       2352
Arg Gln Arg Val Ala Pro Lys Pro Pro Gln Met Ser Arg Ala Ala Asp           
    770                 775                 780                           

gag gct ctc aat gcc atg act tcc aat ggc agc cac cgg ctg atc gag       2400
Glu Ala Leu Asn Ala Met Thr Ser Asn Gly Ser His Arg Leu Ile Glu           
785                 790                 795                 800           

ggg gtc cac cca ggg tct ctg gtg gag aaa ctg cct gac agc cct gcc       2448
Gly Val His Pro Gly Ser Leu Val Glu Lys Leu Pro Asp Ser Pro Ala           
                805                 810                 815               

ctg gcc aag aag gca tta ctg gcg ctg aac cat ggg ctg gac aag gcc       2496
Leu Ala Lys Lys Ala Leu Leu Ala Leu Asn His Gly Leu Asp Lys Ala           
            820                 825                 830                   

cac agc ctg atg gag ctg agc ccc tca gcc cca cct ggt ggc tct cca       2544
His Ser Leu Met Glu Leu Ser Pro Ser Ala Pro Pro Gly Gly Ser Pro           
        835                 840                 845                       

cat ttg gat tct tcc cgt tct cac agc ccc agc tcc cca gac cca gac       2592
His Leu Asp Ser Ser Arg Ser His Ser Pro Ser Ser Pro Asp Pro Asp           
    850                 855                 860                           

aca cca tct cca gtt ggg gac agc cga gcc ctg caa gcc agc cga aac       2640
Thr Pro Ser Pro Val Gly Asp Ser Arg Ala Leu Gln Ala Ser Arg Asn           
865                 870                 875                 880           

aca cgc att ccc cac ctg gct ggc aag aag gct gtg gct gag gag gat       2688
Thr Arg Ile Pro His Leu Ala Gly Lys Lys Ala Val Ala Glu Glu Asp           
                885                 890                 895               

aat ggc tct att ggc gag gaa aca gac tcc agc cca ggc cgg aag aag       2736
Asn Gly Ser Ile Gly Glu Glu Thr Asp Ser Ser Pro Gly Arg Lys Lys           
            900                 905                 910                   

ttt ccc ctc aaa atc ttt aag aag cct ctt aag aag tag                   2775
Phe Pro Leu Lys Ile Phe Lys Lys Pro Leu Lys Lys                           
        915                 920                                           


<210>  10
<211>  924
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  10

Met Asp Val Cys Val Arg Leu Ala Leu Trp Leu Leu Trp Gly Leu Leu 
1               5                   10                  15      


Leu His Gln Gly Gln Ser Leu Ser His Ser His Ser Glu Lys Ala Thr 
            20                  25                  30          


Gly Thr Ser Ser Gly Ala Asn Met Val Ser Lys Gly Glu Glu Leu Phe 
        35                  40                  45              


Thr Gly Val Val Pro Ile Leu Val Glu Leu Asp Gly Asp Val Asn Gly 
    50                  55                  60                  


His Lys Phe Ser Val Ser Gly Glu Gly Glu Gly Asp Ala Thr Tyr Gly 
65                  70                  75                  80  


Lys Leu Thr Leu Lys Phe Ile Cys Thr Thr Gly Lys Leu Pro Val Pro 
                85                  90                  95      


Trp Pro Thr Leu Val Thr Thr Phe Gly Tyr Gly Val Gln Cys Phe Ala 
            100                 105                 110         


Arg Tyr Pro Asp His Met Arg Gln His Asp Phe Phe Lys Ser Ala Met 
        115                 120                 125             


Pro Glu Gly Tyr Val Gln Glu Arg Thr Ile Phe Phe Lys Asp Asp Gly 
    130                 135                 140                 


Asn Tyr Lys Thr Arg Ala Glu Val Lys Phe Glu Gly Asp Thr Leu Val 
145                 150                 155                 160 


Asn Arg Ile Glu Leu Lys Gly Ile Asp Phe Lys Glu Asp Gly Asn Ile 
                165                 170                 175     


Leu Gly His Lys Leu Glu Tyr Asn Tyr Asn Ser His Asn Val Tyr Ile 
            180                 185                 190         


Met Ala Asp Lys Gln Lys Asn Gly Ile Lys Val Asn Phe Lys Ile Arg 
        195                 200                 205             


His Asn Ile Glu Asp Gly Ser Val Gln Leu Ala Asp His Tyr Gln Gln 
    210                 215                 220                 


Asn Thr Pro Ile Gly Asp Gly Pro Val Leu Leu Pro Asp Asn His Tyr 
225                 230                 235                 240 


Leu Ser Tyr Gln Ser Ala Leu Ser Lys Asp Pro Asn Glu Lys Arg Asp 
                245                 250                 255     


His Met Val Leu Leu Glu Phe Val Thr Ala Ala Gly Ile Thr Leu Gly 
            260                 265                 270         


Met Asp Glu Leu Tyr Lys Ser Glu Glu Ser Thr Ala Ala Glu Phe Cys 
        275                 280                 285             


Arg Ile Asp Lys Pro Leu Cys His Ser Glu Asp Glu Lys Leu Ser Phe 
    290                 295                 300                 


Glu Ala Val Arg Asn Ile His Lys Leu Met Asp Asp Asp Ala Asn Gly 
305                 310                 315                 320 


Asp Val Asp Val Glu Glu Ser Asp Glu Phe Leu Arg Glu Asp Leu Asn 
                325                 330                 335     


Tyr His Asp Pro Thr Val Lys His Ser Thr Phe His Gly Glu Asp Lys 
            340                 345                 350         


Leu Ile Ser Val Glu Asp Leu Trp Lys Ala Trp Lys Ser Ser Glu Val 
        355                 360                 365             


Tyr Asn Trp Thr Val Asp Glu Val Val Gln Trp Leu Ile Thr Tyr Val 
    370                 375                 380                 


Glu Leu Pro Gln Tyr Glu Glu Thr Phe Arg Lys Leu Gln Leu Ser Gly 
385                 390                 395                 400 


His Ala Met Pro Arg Leu Ala Val Thr Asn Thr Thr Met Thr Gly Thr 
                405                 410                 415     


Val Leu Lys Met Thr Asp Arg Ser His Arg Gln Lys Leu Gln Leu Lys 
            420                 425                 430         


Ala Leu Asp Thr Val Leu Phe Gly Pro Pro Leu Leu Thr Arg His Asn 
        435                 440                 445             


His Leu Lys Asp Phe Met Leu Val Val Ser Ile Val Ile Gly Val Gly 
    450                 455                 460                 


Gly Cys Trp Phe Ala Tyr Ile Gln Asn Arg Tyr Ser Lys Glu His Met 
465                 470                 475                 480 


Lys Lys Met Met Lys Asp Leu Glu Gly Leu His Arg Ala Glu Gln Ser 
                485                 490                 495     


Leu His Asp Leu Gln Glu Arg Leu His Lys Ala Gln Glu Glu His Arg 
            500                 505                 510         


Thr Val Glu Val Glu Lys Val His Leu Glu Lys Lys Leu Arg Asp Glu 
        515                 520                 525             


Ile Asn Leu Ala Lys Gln Glu Ala Gln Arg Leu Lys Glu Leu Arg Glu 
    530                 535                 540                 


Gly Thr Glu Asn Glu Arg Ser Arg Gln Lys Tyr Ala Glu Glu Glu Leu 
545                 550                 555                 560 


Glu Gln Val Arg Glu Ala Leu Arg Lys Ala Glu Lys Glu Leu Glu Ser 
                565                 570                 575     


His Ser Ser Trp Tyr Ala Pro Glu Ala Leu Gln Lys Trp Leu Gln Leu 
            580                 585                 590         


Thr His Glu Val Glu Val Gln Tyr Tyr Asn Ile Lys Lys Gln Asn Ala 
        595                 600                 605             


Glu Lys Gln Leu Leu Val Ala Lys Glu Gly Ala Glu Lys Ile Lys Lys 
    610                 615                 620                 


Lys Arg Asn Thr Leu Phe Gly Thr Phe His Val Ala His Ser Ser Ser 
625                 630                 635                 640 


Leu Asp Asp Val Asp His Lys Ile Leu Thr Ala Lys Gln Ala Leu Ser 
                645                 650                 655     


Glu Val Thr Ala Ala Leu Arg Glu Arg Leu His Arg Trp Gln Gln Ile 
            660                 665                 670         


Glu Ile Leu Cys Gly Phe Gln Ile Val Asn Asn Pro Gly Ile His Ser 
        675                 680                 685             


Leu Val Ala Ala Leu Asn Ile Asp Pro Ser Trp Met Gly Ser Thr Arg 
    690                 695                 700                 


Pro Asn Pro Ala His Phe Ile Met Thr Asp Asp Val Asp Asp Met Asp 
705                 710                 715                 720 


Glu Glu Ile Val Ser Pro Leu Ser Met Gln Ser Pro Ser Leu Gln Ser 
                725                 730                 735     


Ser Val Arg Gln Arg Leu Thr Glu Pro Gln His Gly Leu Gly Ser Gln 
            740                 745                 750         


Arg Asp Leu Thr His Ser Asp Ser Glu Ser Ser Leu His Met Ser Asp 
        755                 760                 765             


Arg Gln Arg Val Ala Pro Lys Pro Pro Gln Met Ser Arg Ala Ala Asp 
    770                 775                 780                 


Glu Ala Leu Asn Ala Met Thr Ser Asn Gly Ser His Arg Leu Ile Glu 
785                 790                 795                 800 


Gly Val His Pro Gly Ser Leu Val Glu Lys Leu Pro Asp Ser Pro Ala 
                805                 810                 815     


Leu Ala Lys Lys Ala Leu Leu Ala Leu Asn His Gly Leu Asp Lys Ala 
            820                 825                 830         


His Ser Leu Met Glu Leu Ser Pro Ser Ala Pro Pro Gly Gly Ser Pro 
        835                 840                 845             


His Leu Asp Ser Ser Arg Ser His Ser Pro Ser Ser Pro Asp Pro Asp 
    850                 855                 860                 


Thr Pro Ser Pro Val Gly Asp Ser Arg Ala Leu Gln Ala Ser Arg Asn 
865                 870                 875                 880 


Thr Arg Ile Pro His Leu Ala Gly Lys Lys Ala Val Ala Glu Glu Asp 
                885                 890                 895     


Asn Gly Ser Ile Gly Glu Glu Thr Asp Ser Ser Pro Gly Arg Lys Lys 
            900                 905                 910         


Phe Pro Leu Lys Ile Phe Lys Lys Pro Leu Lys Lys 
        915                 920                 


<210>  11
<211>  39
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Forward primer sequence

<400>  11
cggatcctga accaccatgc atccggagcc cgccccgcc                              39


<210>  12
<211>  31
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Reverse primer sequence

<400>  12
gcggccgcct aggcatagtg gctgccgggc g                                      31


<210>  13
<211>  318
<212>  DNA
<213>  Homo sapiens


<220>
<221>  misc_feature
<223>  CL1 CONSTANT REGION coding sequence

<220>
<221>  CDS
<222>  (1)..(318)

<400>  13
ggt cag ccc aag gcc aac ccc act gtc act ctg ttc ccg ccc tcc tct         48
Gly Gln Pro Lys Ala Asn Pro Thr Val Thr Leu Phe Pro Pro Ser Ser           
1               5                   10                  15                

gag gag ctc caa gcc aac aag gcc aca cta gtg tgt ctg atc agt gac         96
Glu Glu Leu Gln Ala Asn Lys Ala Thr Leu Val Cys Leu Ile Ser Asp           
            20                  25                  30                    

ttc tac ccg gga gct gtg aca gtg gcc tgg aag gca gat ggc agc ccc        144
Phe Tyr Pro Gly Ala Val Thr Val Ala Trp Lys Ala Asp Gly Ser Pro           
        35                  40                  45                        

gtc aag gcg gga gtg gag acc acc aaa ccc tcc aaa cag agc aac aac        192
Val Lys Ala Gly Val Glu Thr Thr Lys Pro Ser Lys Gln Ser Asn Asn           
    50                  55                  60                            

aag tac gcg gcc agc agc tac ctg agc ctg acg ccc gag cag tgg aag        240
Lys Tyr Ala Ala Ser Ser Tyr Leu Ser Leu Thr Pro Glu Gln Trp Lys           
65                  70                  75                  80            

tcc cac aga agc tac agc tgc cag gtc acg cat gaa ggg agc acc gtg        288
Ser His Arg Ser Tyr Ser Cys Gln Val Thr His Glu Gly Ser Thr Val           
                85                  90                  95                

gag aag aca gtg gcc cct aca gaa tgt tca                                318
Glu Lys Thr Val Ala Pro Thr Glu Cys Ser                                   
            100                 105                                       


<210>  14
<211>  106
<212>  PRT
<213>  Homo sapiens

<400>  14

Gly Gln Pro Lys Ala Asn Pro Thr Val Thr Leu Phe Pro Pro Ser Ser 
1               5                   10                  15      


Glu Glu Leu Gln Ala Asn Lys Ala Thr Leu Val Cys Leu Ile Ser Asp 
            20                  25                  30          


Phe Tyr Pro Gly Ala Val Thr Val Ala Trp Lys Ala Asp Gly Ser Pro 
        35                  40                  45              


Val Lys Ala Gly Val Glu Thr Thr Lys Pro Ser Lys Gln Ser Asn Asn 
    50                  55                  60                  


Lys Tyr Ala Ala Ser Ser Tyr Leu Ser Leu Thr Pro Glu Gln Trp Lys 
65                  70                  75                  80  


Ser His Arg Ser Tyr Ser Cys Gln Val Thr His Glu Gly Ser Thr Val 
                85                  90                  95      


Glu Lys Thr Val Ala Pro Thr Glu Cys Ser 
            100                 105     


<210>  15
<211>  399
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  2D2.1 VL coding sequence


<220>
<221>  CDS
<222>  (1)..(399)

<400>  15
atg gac atg agg gtg ccc gct cag ctc ctg ggg ctc ctg ctg ctg tgg         48
Met Asp Met Arg Val Pro Ala Gln Leu Leu Gly Leu Leu Leu Leu Trp           
1               5                   10                  15                

ctg aga ggt gcg cgc tgt cag tct gtg ctg acg cag ccg ccc tca gtg         96
Leu Arg Gly Ala Arg Cys Gln Ser Val Leu Thr Gln Pro Pro Ser Val           
            20                  25                  30                    

tct ggg gcc cca ggg cag agg gtc acc atc tcc tgc act ggg agc agc        144
Ser Gly Ala Pro Gly Gln Arg Val Thr Ile Ser Cys Thr Gly Ser Ser           
        35                  40                  45                        

tcc aat atc ggg gca ggt tat aat gta cac tgg tac cag caa ttt cca        192
Ser Asn Ile Gly Ala Gly Tyr Asn Val His Trp Tyr Gln Gln Phe Pro           
    50                  55                  60                            

aga aca gac ccc aaa ctc ctc atc tat gtt tac aac att cgg ccc tca        240
Arg Thr Asp Pro Lys Leu Leu Ile Tyr Val Tyr Asn Ile Arg Pro Ser           
65                  70                  75                  80            

ggg gtc cct gac cga ttc tct ggc tcc agg tct ggc acc tct gcc tcc        288
Gly Val Pro Asp Arg Phe Ser Gly Ser Arg Ser Gly Thr Ser Ala Ser           
                85                  90                  95                

ctg gcc atc act ggg ctc cag act gaa gat gag gct gat tat tac tgc        336
Leu Ala Ile Thr Gly Leu Gln Thr Glu Asp Glu Ala Asp Tyr Tyr Cys           
            100                 105                 110                   

cag tcc tat gac agc agc ctg agt ggt gtg gtt ttc ggc gga ggg acc        384
Gln Ser Tyr Asp Ser Ser Leu Ser Gly Val Val Phe Gly Gly Gly Thr           
        115                 120                 125                       

aag ctg acc gtc cta                                                    399
Lys Leu Thr Val Leu                                                       
    130                                                                   


<210>  16
<211>  133
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  16

Met Asp Met Arg Val Pro Ala Gln Leu Leu Gly Leu Leu Leu Leu Trp 
1               5                   10                  15      


Leu Arg Gly Ala Arg Cys Gln Ser Val Leu Thr Gln Pro Pro Ser Val 
            20                  25                  30          


Ser Gly Ala Pro Gly Gln Arg Val Thr Ile Ser Cys Thr Gly Ser Ser 
        35                  40                  45              


Ser Asn Ile Gly Ala Gly Tyr Asn Val His Trp Tyr Gln Gln Phe Pro 
    50                  55                  60                  


Arg Thr Asp Pro Lys Leu Leu Ile Tyr Val Tyr Asn Ile Arg Pro Ser 
65                  70                  75                  80  


Gly Val Pro Asp Arg Phe Ser Gly Ser Arg Ser Gly Thr Ser Ala Ser 
                85                  90                  95      


Leu Ala Ile Thr Gly Leu Gln Thr Glu Asp Glu Ala Asp Tyr Tyr Cys 
            100                 105                 110         


Gln Ser Tyr Asp Ser Ser Leu Ser Gly Val Val Phe Gly Gly Gly Thr 
        115                 120                 125             


Lys Leu Thr Val Leu 
    130             


<210>  17
<211>  399
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  2B7.1 VL coding sequence


<220>
<221>  CDS
<222>  (1)..(399)

<400>  17
atg gac atg agg gtg ccc gct cag ctc ctg ggg ctc ctg ctg ctg tgg         48
Met Asp Met Arg Val Pro Ala Gln Leu Leu Gly Leu Leu Leu Leu Trp           
1               5                   10                  15                

ctg aga ggt gcg cgc tgt cag tct gtg ctg acg cag ccg ccc tca gtg         96
Leu Arg Gly Ala Arg Cys Gln Ser Val Leu Thr Gln Pro Pro Ser Val           
            20                  25                  30                    

tct ggg gcc cca ggg cag agg gtc acc atc tcc tgc act ggg agc agc        144
Ser Gly Ala Pro Gly Gln Arg Val Thr Ile Ser Cys Thr Gly Ser Ser           
        35                  40                  45                        

tcc aat atc ggg aca ggt tat aat gta cac tgg tac cag caa ttt cca        192
Ser Asn Ile Gly Thr Gly Tyr Asn Val His Trp Tyr Gln Gln Phe Pro           
    50                  55                  60                            

aga aca gac ccc aaa ctc ctc atc tat gtt tac aac att cgg ccc tca        240
Arg Thr Asp Pro Lys Leu Leu Ile Tyr Val Tyr Asn Ile Arg Pro Ser           
65                  70                  75                  80            

ggg gtc cct gac cga ttc tct ggc tcc agg tct ggc acc tct gcc tcc        288
Gly Val Pro Asp Arg Phe Ser Gly Ser Arg Ser Gly Thr Ser Ala Ser           
                85                  90                  95                

ctg gcc atc act gga ctc cag act gaa gat gag gct gat tat tac tgc        336
Leu Ala Ile Thr Gly Leu Gln Thr Glu Asp Glu Ala Asp Tyr Tyr Cys           
            100                 105                 110                   

cag tcc tat gac agc agc ctg agt ggt gtg gtt ttc ggc gga ggg acc        384
Gln Ser Tyr Asp Ser Ser Leu Ser Gly Val Val Phe Gly Gly Gly Thr           
        115                 120                 125                       

aag ctg acc gtc cta                                                    399
Lys Leu Thr Val Leu                                                       
    130                                                                   


<210>  18
<211>  133
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  18

Met Asp Met Arg Val Pro Ala Gln Leu Leu Gly Leu Leu Leu Leu Trp 
1               5                   10                  15      


Leu Arg Gly Ala Arg Cys Gln Ser Val Leu Thr Gln Pro Pro Ser Val 
            20                  25                  30          


Ser Gly Ala Pro Gly Gln Arg Val Thr Ile Ser Cys Thr Gly Ser Ser 
        35                  40                  45              


Ser Asn Ile Gly Thr Gly Tyr Asn Val His Trp Tyr Gln Gln Phe Pro 
    50                  55                  60                  


Arg Thr Asp Pro Lys Leu Leu Ile Tyr Val Tyr Asn Ile Arg Pro Ser 
65                  70                  75                  80  


Gly Val Pro Asp Arg Phe Ser Gly Ser Arg Ser Gly Thr Ser Ala Ser 
                85                  90                  95      


Leu Ala Ile Thr Gly Leu Gln Thr Glu Asp Glu Ala Asp Tyr Tyr Cys 
            100                 105                 110         


Gln Ser Tyr Asp Ser Ser Leu Ser Gly Val Val Phe Gly Gly Gly Thr 
        115                 120                 125             


Lys Leu Thr Val Leu 
    130             


<210>  19
<211>  399
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  2B4.1 VL coding sequence


<220>
<221>  CDS
<222>  (1)..(399)

<400>  19
atg gac atg agg gtg ccc gct cag ctc ctg ggg ctc ctg ctg ctg tgg         48
Met Asp Met Arg Val Pro Ala Gln Leu Leu Gly Leu Leu Leu Leu Trp           
1               5                   10                  15                

ctg aga ggt gcg cgc tgt cag tct gtg ctg acg cag ccg ccc tca gtg         96
Leu Arg Gly Ala Arg Cys Gln Ser Val Leu Thr Gln Pro Pro Ser Val           
            20                  25                  30                    

tct ggg gcc cca ggg cag agg gtc acc atc tcc tgc act ggg agc aat        144
Ser Gly Ala Pro Gly Gln Arg Val Thr Ile Ser Cys Thr Gly Ser Asn           
        35                  40                  45                        

tcc aac atc ggg aca ggt tat gat gtt cac tgg tac cag aaa ctt cca        192
Ser Asn Ile Gly Thr Gly Tyr Asp Val His Trp Tyr Gln Lys Leu Pro           
    50                  55                  60                            

gga aca gcc ccc aga ctc ctc atc tat agt cac ttc aat cgg ccc tca        240
Gly Thr Ala Pro Arg Leu Leu Ile Tyr Ser His Phe Asn Arg Pro Ser           
65                  70                  75                  80            

ggg gtc cct gac cga ttc tct ggc tcc acg tct ggc acc tca gcc tcc        288
Gly Val Pro Asp Arg Phe Ser Gly Ser Thr Ser Gly Thr Ser Ala Ser           
                85                  90                  95                

ctg gcc atc act ggg ctc cag gct gag gat gag gct gat tat tac tgc        336
Leu Ala Ile Thr Gly Leu Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys           
            100                 105                 110                   

cag tcc tat gac agc agc ctg agt ggt tcg gtg ttc ggc gga ggg acc        384
Gln Ser Tyr Asp Ser Ser Leu Ser Gly Ser Val Phe Gly Gly Gly Thr           
        115                 120                 125                       

aag ctg acc gtc cta                                                    399
Lys Leu Thr Val Leu                                                       
    130                                                                   


<210>  20
<211>  133
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  20

Met Asp Met Arg Val Pro Ala Gln Leu Leu Gly Leu Leu Leu Leu Trp 
1               5                   10                  15      


Leu Arg Gly Ala Arg Cys Gln Ser Val Leu Thr Gln Pro Pro Ser Val 
            20                  25                  30          


Ser Gly Ala Pro Gly Gln Arg Val Thr Ile Ser Cys Thr Gly Ser Asn 
        35                  40                  45              


Ser Asn Ile Gly Thr Gly Tyr Asp Val His Trp Tyr Gln Lys Leu Pro 
    50                  55                  60                  


Gly Thr Ala Pro Arg Leu Leu Ile Tyr Ser His Phe Asn Arg Pro Ser 
65                  70                  75                  80  


Gly Val Pro Asp Arg Phe Ser Gly Ser Thr Ser Gly Thr Ser Ala Ser 
                85                  90                  95      


Leu Ala Ile Thr Gly Leu Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys 
            100                 105                 110         


Gln Ser Tyr Asp Ser Ser Leu Ser Gly Ser Val Phe Gly Gly Gly Thr 
        115                 120                 125             


Lys Leu Thr Val Leu 
    130             


<210>  21
<211>  978
<212>  DNA
<213>  Homo sapiens


<220>
<221>  misc_feature
<223>  IgG2 constant region coding sequence

<220>
<221>  CDS
<222>  (1)..(978)

<400>  21
gcc tcc acc aag ggc cca tcg gtc ttc ccc ctg gcg ccc tgc tcc agg         48
Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Cys Ser Arg           
1               5                   10                  15                

agc acc tcc gag agc aca gcg gcc ctg ggc tgc ctg gtc aag gac tac         96
Ser Thr Ser Glu Ser Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr           
            20                  25                  30                    

ttc ccc gaa ccg gtg acg gtg tcg tgg aac tca ggc gct ctg acc agc        144
Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser           
        35                  40                  45                        

ggc gtg cac acc ttc cca gct gtc cta cag tcc tca gga ctc tac tcc        192
Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser           
    50                  55                  60                            

ctc agc agc gtg gtg acc gtg ccc tcc agc aac ttc ggc acc cag acc        240
Leu Ser Ser Val Val Thr Val Pro Ser Ser Asn Phe Gly Thr Gln Thr           
65                  70                  75                  80            

tac acc tgc aac gta gat cac aag ccc agc aac acc aag gtg gac aag        288
Tyr Thr Cys Asn Val Asp His Lys Pro Ser Asn Thr Lys Val Asp Lys           
                85                  90                  95                

aca gtt gag cgc aaa tgt tgt gtc gag tgc cca ccg tgc cca gca cca        336
Thr Val Glu Arg Lys Cys Cys Val Glu Cys Pro Pro Cys Pro Ala Pro           
            100                 105                 110                   

cct gtg gca gga ccg tca gtc ttc ctc ttc ccc cca aaa ccc aag gac        384
Pro Val Ala Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp           
        115                 120                 125                       

acc ctc atg atc tcc cgg acc cct gag gtc acg tgc gtg gtg gtg gac        432
Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp           
    130                 135                 140                           

gtg agc cac gaa gac ccc gag gtc cag ttc aac tgg tac gtg gac ggc        480
Val Ser His Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly           
145                 150                 155                 160           

gtg gag gtg cat aat gcc aag aca aag cca cgg gag gag cag ttc aac        528
Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn           
                165                 170                 175               

agc acg ttc cgt gtg gtc agc gtc ctc acc gtt gtg cac cag gac tgg        576
Ser Thr Phe Arg Val Val Ser Val Leu Thr Val Val His Gln Asp Trp           
            180                 185                 190                   

ctg aac ggc aag gag tac aag tgc aag gtc tcc aac aaa ggc ctc cca        624
Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro           
        195                 200                 205                       

gcc ccc atc gag aaa acc atc tcc aaa acc aaa ggg cag ccc cga gaa        672
Ala Pro Ile Glu Lys Thr Ile Ser Lys Thr Lys Gly Gln Pro Arg Glu           
    210                 215                 220                           

cca cag gtg tac acc ctg ccc cca tcc cgg gag gag atg acc aag aac        720
Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn           
225                 230                 235                 240           

cag gtc agc ctg acc tgc ctg gtc aaa ggc ttc tac ccc agc gac atc        768
Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile           
                245                 250                 255               

gcc gtg gag tgg gag agc aat ggg cag ccg gag aac aac tac aag acc        816
Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr           
            260                 265                 270                   

aca cct ccc atg ctg gac tcc gac ggc tcc ttc ttc ctc tac agc aag        864
Thr Pro Pro Met Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys           
        275                 280                 285                       

ctc acc gtg gac aag agc agg tgg cag cag ggg aac gtc ttc tca tgc        912
Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys           
    290                 295                 300                           

tcc gtg atg cat gag gct ctg cac aac cac tac acg cag aag agc ctc        960
Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu           
305                 310                 315                 320           

tcc ctg tct ccg ggt aaa                                                978
Ser Leu Ser Pro Gly Lys                                                   
                325                                                       


<210>  22
<211>  326
<212>  PRT
<213>  Homo sapiens

<400>  22

Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Cys Ser Arg 
1               5                   10                  15      


Ser Thr Ser Glu Ser Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Asn Phe Gly Thr Gln Thr 
65                  70                  75                  80  


Tyr Thr Cys Asn Val Asp His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      


Thr Val Glu Arg Lys Cys Cys Val Glu Cys Pro Pro Cys Pro Ala Pro 
            100                 105                 110         


Pro Val Ala Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp 
        115                 120                 125             


Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp 
    130                 135                 140                 


Val Ser His Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly 
145                 150                 155                 160 


Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn 
                165                 170                 175     


Ser Thr Phe Arg Val Val Ser Val Leu Thr Val Val His Gln Asp Trp 
            180                 185                 190         


Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro 
        195                 200                 205             


Ala Pro Ile Glu Lys Thr Ile Ser Lys Thr Lys Gly Gln Pro Arg Glu 
    210                 215                 220                 


Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn 
225                 230                 235                 240 


Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile 
                245                 250                 255     


Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr 
            260                 265                 270         


Thr Pro Pro Met Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys 
        275                 280                 285             


Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys 
    290                 295                 300                 


Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu 
305                 310                 315                 320 


Ser Leu Ser Pro Gly Lys 
                325     


<210>  23
<211>  426
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  2D2.1 VH coding sequence


<220>
<221>  CDS
<222>  (1)..(426)

<400>  23
atg gac atg agg gtg ccc gct cag ctc ctg ggg ctc ctg ctg ctg tgg         48
Met Asp Met Arg Val Pro Ala Gln Leu Leu Gly Leu Leu Leu Leu Trp           
1               5                   10                  15                

ctg aga ggt gcg cgc tgt cag gtg cag cta cag cag tgg ggc gca gga         96
Leu Arg Gly Ala Arg Cys Gln Val Gln Leu Gln Gln Trp Gly Ala Gly           
            20                  25                  30                    

ctg ttg aag cct tcg gag acc ctg tcc ctc acc tgc gct gtc tat ggt        144
Leu Leu Lys Pro Ser Glu Thr Leu Ser Leu Thr Cys Ala Val Tyr Gly           
        35                  40                  45                        

ggg tcc ttc agt ggt tac tac tgg agc tgg atc cgc cag ccc ccc gga        192
Gly Ser Phe Ser Gly Tyr Tyr Trp Ser Trp Ile Arg Gln Pro Pro Gly           
    50                  55                  60                            

aag ggg ctg gag tgg att ggg gaa atc gat cat agt gga agg ata aat        240
Lys Gly Leu Glu Trp Ile Gly Glu Ile Asp His Ser Gly Arg Ile Asn           
65                  70                  75                  80            

tac aac ccg gcc ctc aag agt cga ctc acc ata tca gtt gac acg tcc        288
Tyr Asn Pro Ala Leu Lys Ser Arg Leu Thr Ile Ser Val Asp Thr Ser           
                85                  90                  95                

aag aac cag ttc tcc ctg aag ctg agc tct gtg acc gcc gcg gac acg        336
Lys Asn Gln Phe Ser Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr           
            100                 105                 110                   

gct gtg tat tac tgt gcg aga gca ggt tcg ggg ggt tat gag gac tgg        384
Ala Val Tyr Tyr Cys Ala Arg Ala Gly Ser Gly Gly Tyr Glu Asp Trp           
        115                 120                 125                       

ttc gac ccc tgg ggc cag gga acc ctg gtc acc gtc tct agt                426
Phe Asp Pro Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser                   
    130                 135                 140                           


<210>  24
<211>  142
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  24

Met Asp Met Arg Val Pro Ala Gln Leu Leu Gly Leu Leu Leu Leu Trp 
1               5                   10                  15      


Leu Arg Gly Ala Arg Cys Gln Val Gln Leu Gln Gln Trp Gly Ala Gly 
            20                  25                  30          


Leu Leu Lys Pro Ser Glu Thr Leu Ser Leu Thr Cys Ala Val Tyr Gly 
        35                  40                  45              


Gly Ser Phe Ser Gly Tyr Tyr Trp Ser Trp Ile Arg Gln Pro Pro Gly 
    50                  55                  60                  


Lys Gly Leu Glu Trp Ile Gly Glu Ile Asp His Ser Gly Arg Ile Asn 
65                  70                  75                  80  


Tyr Asn Pro Ala Leu Lys Ser Arg Leu Thr Ile Ser Val Asp Thr Ser 
                85                  90                  95      


Lys Asn Gln Phe Ser Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr 
            100                 105                 110         


Ala Val Tyr Tyr Cys Ala Arg Ala Gly Ser Gly Gly Tyr Glu Asp Trp 
        115                 120                 125             


Phe Asp Pro Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
    130                 135                 140         


<210>  25
<211>  426
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  2C1.1 VH coding sequence


<220>
<221>  CDS
<222>  (1)..(426)

<400>  25
atg gac atg agg gtg ccc gct cag ctc ctg ggg ctc ctg ctg ctg tgg         48
Met Asp Met Arg Val Pro Ala Gln Leu Leu Gly Leu Leu Leu Leu Trp           
1               5                   10                  15                

ctg aga ggt gcg cgc tgt cag gtg cag cta cag cag tgg ggc gca gga         96
Leu Arg Gly Ala Arg Cys Gln Val Gln Leu Gln Gln Trp Gly Ala Gly           
            20                  25                  30                    

ctg ttg aag cct tcg gag act ctg tcc ctc acc tgc gct gtc tat ggt        144
Leu Leu Lys Pro Ser Glu Thr Leu Ser Leu Thr Cys Ala Val Tyr Gly           
        35                  40                  45                        

ggg tcc ttc agt ggt tac tac tgg agc tgg atc cgc cag ccc ccc gga        192
Gly Ser Phe Ser Gly Tyr Tyr Trp Ser Trp Ile Arg Gln Pro Pro Gly           
    50                  55                  60                            

aag ggg ctg gag tgg att ggg gaa atc gat cat agt gga agc acc aac        240
Lys Gly Leu Glu Trp Ile Gly Glu Ile Asp His Ser Gly Ser Thr Asn           
65                  70                  75                  80            

tac aac ccg gcc ctc aag agt cga ctc acc ata tca gtt gac acg tcc        288
Tyr Asn Pro Ala Leu Lys Ser Arg Leu Thr Ile Ser Val Asp Thr Ser           
                85                  90                  95                

aag aac cag ttc tcc ctg aag ctg agc tct gtg acc gcc gcg gac acg        336
Lys Asn Gln Phe Ser Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr           
            100                 105                 110                   

gct gtg tat tac tgt gcg aga gca ggt tcg ggg ggt tat gag gac tgg        384
Ala Val Tyr Tyr Cys Ala Arg Ala Gly Ser Gly Gly Tyr Glu Asp Trp           
        115                 120                 125                       

ttc gac ccc tgg ggc cag gga acc ctg gtc acc gtc tct agt                426
Phe Asp Pro Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser                   
    130                 135                 140                           


<210>  26
<211>  142
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  26

Met Asp Met Arg Val Pro Ala Gln Leu Leu Gly Leu Leu Leu Leu Trp 
1               5                   10                  15      


Leu Arg Gly Ala Arg Cys Gln Val Gln Leu Gln Gln Trp Gly Ala Gly 
            20                  25                  30          


Leu Leu Lys Pro Ser Glu Thr Leu Ser Leu Thr Cys Ala Val Tyr Gly 
        35                  40                  45              


Gly Ser Phe Ser Gly Tyr Tyr Trp Ser Trp Ile Arg Gln Pro Pro Gly 
    50                  55                  60                  


Lys Gly Leu Glu Trp Ile Gly Glu Ile Asp His Ser Gly Ser Thr Asn 
65                  70                  75                  80  


Tyr Asn Pro Ala Leu Lys Ser Arg Leu Thr Ile Ser Val Asp Thr Ser 
                85                  90                  95      


Lys Asn Gln Phe Ser Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr 
            100                 105                 110         


Ala Val Tyr Tyr Cys Ala Arg Ala Gly Ser Gly Gly Tyr Glu Asp Trp 
        115                 120                 125             


Phe Asp Pro Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
    130                 135                 140         


<210>  27
<211>  426
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  2G1.1 VH coding sequence


<220>
<221>  CDS
<222>  (1)..(426)

<400>  27
atg gac atg agg gtg ccc gct cag ctc ctg ggg ctc ctg ctg ctg tgg         48
Met Asp Met Arg Val Pro Ala Gln Leu Leu Gly Leu Leu Leu Leu Trp           
1               5                   10                  15                

ctg aga ggt gcg cgc tgt gag gtg cag ctg gtg gag tct ggg gga ggc         96
Leu Arg Gly Ala Arg Cys Glu Val Gln Leu Val Glu Ser Gly Gly Gly           
            20                  25                  30                    

ttg gtc cag cct ggg ggg tcc ctg aga ctc tcc tgt gca gcc tct gga        144
Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly           
        35                  40                  45                        

ttc acc ttt agt agc tat tgg atg agc tgg gtc cgc cag gct cca ggg        192
Phe Thr Phe Ser Ser Tyr Trp Met Ser Trp Val Arg Gln Ala Pro Gly           
    50                  55                  60                            

aag ggg ctg gag tgg gtg gcc aac ata aag cac gat gga agt gag aaa        240
Lys Gly Leu Glu Trp Val Ala Asn Ile Lys His Asp Gly Ser Glu Lys           
65                  70                  75                  80            

tac tat gtg gac tct gtg aag ggc cga ttc acc atc tcc aga gac aat        288
Tyr Tyr Val Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn           
                85                  90                  95                

gcc aag aac tca ctg cat ctg caa atg atc agc ctg aga gcc gag gac        336
Ala Lys Asn Ser Leu His Leu Gln Met Ile Ser Leu Arg Ala Glu Asp           
            100                 105                 110                   

acg gct gtg tat tac tgt gcg aaa aga tat agc ggt ggc tgg acc ttc        384
Thr Ala Val Tyr Tyr Cys Ala Lys Arg Tyr Ser Gly Gly Trp Thr Phe           
        115                 120                 125                       

ttt gac tac tgg ggc cag gga acc ctg gtc acc gtc tct agt                426
Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser                   
    130                 135                 140                           


<210>  28
<211>  142
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  28

Met Asp Met Arg Val Pro Ala Gln Leu Leu Gly Leu Leu Leu Leu Trp 
1               5                   10                  15      


Leu Arg Gly Ala Arg Cys Glu Val Gln Leu Val Glu Ser Gly Gly Gly 
            20                  25                  30          


Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly 
        35                  40                  45              


Phe Thr Phe Ser Ser Tyr Trp Met Ser Trp Val Arg Gln Ala Pro Gly 
    50                  55                  60                  


Lys Gly Leu Glu Trp Val Ala Asn Ile Lys His Asp Gly Ser Glu Lys 
65                  70                  75                  80  


Tyr Tyr Val Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn 
                85                  90                  95      


Ala Lys Asn Ser Leu His Leu Gln Met Ile Ser Leu Arg Ala Glu Asp 
            100                 105                 110         


Thr Ala Val Tyr Tyr Cys Ala Lys Arg Tyr Ser Gly Gly Trp Thr Phe 
        115                 120                 125             


Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
    130                 135                 140         


<210>  29
<211>  466
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  H4 (2B4.1 HC)

<400>  29

Met Asp Met Arg Val Pro Ala Gln Leu Leu Gly Leu Leu Leu Leu Trp 
1               5                   10                  15      


Leu Arg Gly Ala Arg Cys Gln Val Gln Leu Val Gln Ser Gly Ala Glu 
            20                  25                  30          


Val Lys Lys Pro Gly Ala Ser Val Lys Val Ser Cys Lys Ala Ser Gly 
        35                  40                  45              


Tyr Thr Phe Thr Asp Tyr Tyr Met His Trp Val Arg Gln Ala Pro Gly 
    50                  55                  60                  


Gln Gly Leu Glu Trp Met Gly Trp Ile Asn Pro Asn Ser Gly Gly Thr 
65                  70                  75                  80  


Asn Tyr Val Gln Lys Phe Gln Asp Arg Val Thr Met Thr Arg Asp Thr 
                85                  90                  95      


Ser Ile Thr Thr Ala Tyr Met Glu Leu Thr Arg Leu Arg Ser Asp Asp 
            100                 105                 110         


Thr Ala Val Tyr Tyr Cys Ala Arg Glu Glu Gly Asp Tyr Gly Met Asp 
        115                 120                 125             


Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser Ala Ser Thr Lys 
    130                 135                 140                 


Gly Pro Ser Val Phe Pro Leu Ala Pro Cys Ser Arg Ser Thr Ser Glu 
145                 150                 155                 160 


Ser Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro 
                165                 170                 175     


Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr 
            180                 185                 190         


Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val 
        195                 200                 205             


Val Thr Val Pro Ser Ser Asn Phe Gly Thr Gln Thr Tyr Thr Cys Asn 
    210                 215                 220                 


Val Asp His Lys Pro Ser Asn Thr Lys Val Asp Lys Thr Val Glu Arg 
225                 230                 235                 240 


Lys Cys Cys Val Glu Cys Pro Pro Cys Pro Ala Pro Pro Val Ala Gly 
                245                 250                 255     


Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile 
            260                 265                 270         


Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu 
        275                 280                 285             


Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His 
    290                 295                 300                 


Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Phe Arg 
305                 310                 315                 320 


Val Val Ser Val Leu Thr Val Val His Gln Asp Trp Leu Asn Gly Lys 
                325                 330                 335     


Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro Ala Pro Ile Glu 
            340                 345                 350         


Lys Thr Ile Ser Lys Thr Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr 
        355                 360                 365             


Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu 
    370                 375                 380                 


Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp 
385                 390                 395                 400 


Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Met 
                405                 410                 415     


Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp 
            420                 425                 430         


Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His 
        435                 440                 445             


Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro 
    450                 455                 460                 


Gly Lys 
465     


<210>  30
<211>  239
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  L3 (2B4.1 LC)

<400>  30

Met Asp Met Arg Val Pro Ala Gln Leu Leu Gly Leu Leu Leu Leu Trp 
1               5                   10                  15      


Leu Arg Gly Ala Arg Cys Gln Ser Val Leu Thr Gln Pro Pro Ser Val 
            20                  25                  30          


Ser Gly Ala Pro Gly Gln Arg Val Thr Ile Ser Cys Thr Gly Ser Asn 
        35                  40                  45              


Ser Asn Ile Gly Thr Gly Tyr Asp Val His Trp Tyr Gln Lys Leu Pro 
    50                  55                  60                  


Gly Thr Ala Pro Arg Leu Leu Ile Tyr Ser His Phe Asn Arg Pro Ser 
65                  70                  75                  80  


Gly Val Pro Asp Arg Phe Ser Gly Ser Thr Ser Gly Thr Ser Ala Ser 
                85                  90                  95      


Leu Ala Ile Thr Gly Leu Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys 
            100                 105                 110         


Gln Ser Tyr Asp Ser Ser Leu Ser Gly Ser Val Phe Gly Gly Gly Thr 
        115                 120                 125             


Lys Leu Thr Val Leu Gly Gln Pro Lys Ala Asn Pro Thr Val Thr Leu 
    130                 135                 140                 


Phe Pro Pro Ser Ser Glu Glu Leu Gln Ala Asn Lys Ala Thr Leu Val 
145                 150                 155                 160 


Cys Leu Ile Ser Asp Phe Tyr Pro Gly Ala Val Thr Val Ala Trp Lys 
                165                 170                 175     


Ala Asp Gly Ser Pro Val Lys Ala Gly Val Glu Thr Thr Lys Pro Ser 
            180                 185                 190         


Lys Gln Ser Asn Asn Lys Tyr Ala Ala Ser Ser Tyr Leu Ser Leu Thr 
        195                 200                 205             


Pro Glu Gln Trp Lys Ser His Arg Ser Tyr Ser Cys Gln Val Thr His 
    210                 215                 220                 


Glu Gly Ser Thr Val Glu Lys Thr Val Ala Pro Thr Glu Cys Ser 
225                 230                 235                 


<210>  31
<211>  239
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  L1 (HC OF 2D2.1, 2C1.1, AND 2G1.1)

<400>  31

Met Asp Met Arg Val Pro Ala Gln Leu Leu Gly Leu Leu Leu Leu Trp 
1               5                   10                  15      


Leu Arg Gly Ala Arg Cys Gln Ser Val Leu Thr Gln Pro Pro Ser Val 
            20                  25                  30          


Ser Gly Ala Pro Gly Gln Arg Val Thr Ile Ser Cys Thr Gly Ser Ser 
        35                  40                  45              


Ser Asn Ile Gly Ala Gly Tyr Asn Val His Trp Tyr Gln Gln Phe Pro 
    50                  55                  60                  


Arg Thr Asp Pro Lys Leu Leu Ile Tyr Val Tyr Asn Ile Arg Pro Ser 
65                  70                  75                  80  


Gly Val Pro Asp Arg Phe Ser Gly Ser Arg Ser Gly Thr Ser Ala Ser 
                85                  90                  95      


Leu Ala Ile Thr Gly Leu Gln Thr Glu Asp Glu Ala Asp Tyr Tyr Cys 
            100                 105                 110         


Gln Ser Tyr Asp Ser Ser Leu Ser Gly Val Val Phe Gly Gly Gly Thr 
        115                 120                 125             


Lys Leu Thr Val Leu Gly Gln Pro Lys Ala Asn Pro Thr Val Thr Leu 
    130                 135                 140                 


Phe Pro Pro Ser Ser Glu Glu Leu Gln Ala Asn Lys Ala Thr Leu Val 
145                 150                 155                 160 


Cys Leu Ile Ser Asp Phe Tyr Pro Gly Ala Val Thr Val Ala Trp Lys 
                165                 170                 175     


Ala Asp Gly Ser Pro Val Lys Ala Gly Val Glu Thr Thr Lys Pro Ser 
            180                 185                 190         


Lys Gln Ser Asn Asn Lys Tyr Ala Ala Ser Ser Tyr Leu Ser Leu Thr 
        195                 200                 205             


Pro Glu Gln Trp Lys Ser His Arg Ser Tyr Ser Cys Gln Val Thr His 
    210                 215                 220                 


Glu Gly Ser Thr Val Glu Lys Thr Val Ala Pro Thr Glu Cys Ser 
225                 230                 235                 


<210>  32
<211>  239
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  L2

<400>  32

Met Asp Met Arg Val Pro Ala Gln Leu Leu Gly Leu Leu Leu Leu Trp 
1               5                   10                  15      


Leu Arg Gly Ala Arg Cys Gln Ser Val Leu Thr Gln Pro Pro Ser Val 
            20                  25                  30          


Ser Gly Ala Pro Gly Gln Arg Val Thr Ile Ser Cys Thr Gly Ser Ser 
        35                  40                  45              


Ser Asn Ile Gly Thr Gly Tyr Asn Val His Trp Tyr Gln Gln Phe Pro 
    50                  55                  60                  


Arg Thr Asp Pro Lys Leu Leu Ile Tyr Val Tyr Asn Ile Arg Pro Ser 
65                  70                  75                  80  


Gly Val Pro Asp Arg Phe Ser Gly Ser Arg Ser Gly Thr Ser Ala Ser 
                85                  90                  95      


Leu Ala Ile Thr Gly Leu Gln Thr Glu Asp Glu Ala Asp Tyr Tyr Cys 
            100                 105                 110         


Gln Ser Tyr Asp Ser Ser Leu Ser Gly Val Val Phe Gly Gly Gly Thr 
        115                 120                 125             


Lys Leu Thr Val Leu Gly Gln Pro Lys Ala Asn Pro Thr Val Thr Leu 
    130                 135                 140                 


Phe Pro Pro Ser Ser Glu Glu Leu Gln Ala Asn Lys Ala Thr Leu Val 
145                 150                 155                 160 


Cys Leu Ile Ser Asp Phe Tyr Pro Gly Ala Val Thr Val Ala Trp Lys 
                165                 170                 175     


Ala Asp Gly Ser Pro Val Lys Ala Gly Val Glu Thr Thr Lys Pro Ser 
            180                 185                 190         


Lys Gln Ser Asn Asn Lys Tyr Ala Ala Ser Ser Tyr Leu Ser Leu Thr 
        195                 200                 205             


Pro Glu Gln Trp Lys Ser His Arg Ser Tyr Ser Cys Gln Val Thr His 
    210                 215                 220                 


Glu Gly Ser Thr Val Glu Lys Thr Val Ala Pro Thr Glu Cys Ser 
225                 230                 235                 


<210>  33
<211>  468
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  H1

<400>  33

Met Asp Met Arg Val Pro Ala Gln Leu Leu Gly Leu Leu Leu Leu Trp 
1               5                   10                  15      


Leu Arg Gly Ala Arg Cys Gln Val Gln Leu Gln Gln Trp Gly Ala Gly 
            20                  25                  30          


Leu Leu Lys Pro Ser Glu Thr Leu Ser Leu Thr Cys Ala Val Tyr Gly 
        35                  40                  45              


Gly Ser Phe Ser Gly Tyr Tyr Trp Ser Trp Ile Arg Gln Pro Pro Gly 
    50                  55                  60                  


Lys Gly Leu Glu Trp Ile Gly Glu Ile Asp His Ser Gly Arg Ile Asn 
65                  70                  75                  80  


Tyr Asn Pro Ala Leu Lys Ser Arg Leu Thr Ile Ser Val Asp Thr Ser 
                85                  90                  95      


Lys Asn Gln Phe Ser Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr 
            100                 105                 110         


Ala Val Tyr Tyr Cys Ala Arg Ala Gly Ser Gly Gly Tyr Glu Asp Trp 
        115                 120                 125             


Phe Asp Pro Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser 
    130                 135                 140                 


Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Cys Ser Arg Ser Thr 
145                 150                 155                 160 


Ser Glu Ser Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro 
                165                 170                 175     


Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val 
            180                 185                 190         


His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser 
        195                 200                 205             


Ser Val Val Thr Val Pro Ser Ser Asn Phe Gly Thr Gln Thr Tyr Thr 
    210                 215                 220                 


Cys Asn Val Asp His Lys Pro Ser Asn Thr Lys Val Asp Lys Thr Val 
225                 230                 235                 240 


Glu Arg Lys Cys Cys Val Glu Cys Pro Pro Cys Pro Ala Pro Pro Val 
                245                 250                 255     


Ala Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu 
            260                 265                 270         


Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser 
        275                 280                 285             


His Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu 
    290                 295                 300                 


Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr 
305                 310                 315                 320 


Phe Arg Val Val Ser Val Leu Thr Val Val His Gln Asp Trp Leu Asn 
                325                 330                 335     


Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro Ala Pro 
            340                 345                 350         


Ile Glu Lys Thr Ile Ser Lys Thr Lys Gly Gln Pro Arg Glu Pro Gln 
        355                 360                 365             


Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val 
    370                 375                 380                 


Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val 
385                 390                 395                 400 


Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro 
                405                 410                 415     


Pro Met Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr 
            420                 425                 430         


Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val 
        435                 440                 445             


Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu 
    450                 455                 460                 


Ser Pro Gly Lys 
465             


<210>  34
<211>  468
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  H2

<400>  34

Met Asp Met Arg Val Pro Ala Gln Leu Leu Gly Leu Leu Leu Leu Trp 
1               5                   10                  15      


Leu Arg Gly Ala Arg Cys Gln Val Gln Leu Gln Gln Trp Gly Ala Gly 
            20                  25                  30          


Leu Leu Lys Pro Ser Glu Thr Leu Ser Leu Thr Cys Ala Val Tyr Gly 
        35                  40                  45              


Gly Ser Phe Ser Gly Tyr Tyr Trp Ser Trp Ile Arg Gln Pro Pro Gly 
    50                  55                  60                  


Lys Gly Leu Glu Trp Ile Gly Glu Ile Asp His Ser Gly Ser Thr Asn 
65                  70                  75                  80  


Tyr Asn Pro Ala Leu Lys Ser Arg Leu Thr Ile Ser Val Asp Thr Ser 
                85                  90                  95      


Lys Asn Gln Phe Ser Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr 
            100                 105                 110         


Ala Val Tyr Tyr Cys Ala Arg Ala Gly Ser Gly Gly Tyr Glu Asp Trp 
        115                 120                 125             


Phe Asp Pro Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser 
    130                 135                 140                 


Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Cys Ser Arg Ser Thr 
145                 150                 155                 160 


Ser Glu Ser Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro 
                165                 170                 175     


Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val 
            180                 185                 190         


His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser 
        195                 200                 205             


Ser Val Val Thr Val Pro Ser Ser Asn Phe Gly Thr Gln Thr Tyr Thr 
    210                 215                 220                 


Cys Asn Val Asp His Lys Pro Ser Asn Thr Lys Val Asp Lys Thr Val 
225                 230                 235                 240 


Glu Arg Lys Cys Cys Val Glu Cys Pro Pro Cys Pro Ala Pro Pro Val 
                245                 250                 255     


Ala Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu 
            260                 265                 270         


Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser 
        275                 280                 285             


His Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu 
    290                 295                 300                 


Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr 
305                 310                 315                 320 


Phe Arg Val Val Ser Val Leu Thr Val Val His Gln Asp Trp Leu Asn 
                325                 330                 335     


Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro Ala Pro 
            340                 345                 350         


Ile Glu Lys Thr Ile Ser Lys Thr Lys Gly Gln Pro Arg Glu Pro Gln 
        355                 360                 365             


Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val 
    370                 375                 380                 


Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val 
385                 390                 395                 400 


Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro 
                405                 410                 415     


Pro Met Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr 
            420                 425                 430         


Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val 
        435                 440                 445             


Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu 
    450                 455                 460                 


Ser Pro Gly Lys 
465             


<210>  35
<211>  468
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  H3

<400>  35

Met Asp Met Arg Val Pro Ala Gln Leu Leu Gly Leu Leu Leu Leu Trp 
1               5                   10                  15      


Leu Arg Gly Ala Arg Cys Glu Val Gln Leu Val Glu Ser Gly Gly Gly 
            20                  25                  30          


Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly 
        35                  40                  45              


Phe Thr Phe Ser Ser Tyr Trp Met Ser Trp Val Arg Gln Ala Pro Gly 
    50                  55                  60                  


Lys Gly Leu Glu Trp Val Ala Asn Ile Lys His Asp Gly Ser Glu Lys 
65                  70                  75                  80  


Tyr Tyr Val Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn 
                85                  90                  95      


Ala Lys Asn Ser Leu His Leu Gln Met Ile Ser Leu Arg Ala Glu Asp 
            100                 105                 110         


Thr Ala Val Tyr Tyr Cys Ala Lys Arg Tyr Ser Gly Gly Trp Thr Phe 
        115                 120                 125             


Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser 
    130                 135                 140                 


Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Cys Ser Arg Ser Thr 
145                 150                 155                 160 


Ser Glu Ser Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro 
                165                 170                 175     


Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val 
            180                 185                 190         


His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser 
        195                 200                 205             


Ser Val Val Thr Val Pro Ser Ser Asn Phe Gly Thr Gln Thr Tyr Thr 
    210                 215                 220                 


Cys Asn Val Asp His Lys Pro Ser Asn Thr Lys Val Asp Lys Thr Val 
225                 230                 235                 240 


Glu Arg Lys Cys Cys Val Glu Cys Pro Pro Cys Pro Ala Pro Pro Val 
                245                 250                 255     


Ala Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu 
            260                 265                 270         


Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser 
        275                 280                 285             


His Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu 
    290                 295                 300                 


Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr 
305                 310                 315                 320 


Phe Arg Val Val Ser Val Leu Thr Val Val His Gln Asp Trp Leu Asn 
                325                 330                 335     


Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro Ala Pro 
            340                 345                 350         


Ile Glu Lys Thr Ile Ser Lys Thr Lys Gly Gln Pro Arg Glu Pro Gln 
        355                 360                 365             


Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val 
    370                 375                 380                 


Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val 
385                 390                 395                 400 


Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro 
                405                 410                 415     


Pro Met Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr 
            420                 425                 430         


Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val 
        435                 440                 445             


Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu 
    450                 455                 460                 


Ser Pro Gly Lys 
465             


<210>  36
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL1

<400>  36

Gln Ser Val Leu Thr Gln Pro Pro Ser Val Ser Gly Ala Pro Gly Gln 
1               5                   10                  15      


Arg Val Thr Ile Ser Cys Thr Gly Ser Ser Ser Asn Ile Gly Ala Gly 
            20                  25                  30          


Tyr Asn Val His Trp Tyr Gln Gln Phe Pro Arg Thr Asp Pro Lys Leu 
        35                  40                  45              


Leu Ile Tyr Val Tyr Asn Ile Arg Pro Ser Gly Val Pro Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Arg Ser Gly Thr Ser Ala Ser Leu Ala Ile Thr Gly Leu 
65                  70                  75                  80  


Gln Thr Glu Asp Glu Ala Asp Tyr Tyr Cys Gln Ser Tyr Asp Ser Ser 
                85                  90                  95      


Leu Ser Gly Val Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 110     


<210>  37
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL2

<400>  37

Gln Ser Val Leu Thr Gln Pro Pro Ser Val Ser Gly Ala Pro Gly Gln 
1               5                   10                  15      


Arg Val Thr Ile Ser Cys Thr Gly Ser Ser Ser Asn Ile Gly Thr Gly 
            20                  25                  30          


Tyr Asn Val His Trp Tyr Gln Gln Phe Pro Arg Thr Asp Pro Lys Leu 
        35                  40                  45              


Leu Ile Tyr Val Tyr Asn Ile Arg Pro Ser Gly Val Pro Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Arg Ser Gly Thr Ser Ala Ser Leu Ala Ile Thr Gly Leu 
65                  70                  75                  80  


Gln Thr Glu Asp Glu Ala Asp Tyr Tyr Cys Gln Ser Tyr Asp Ser Ser 
                85                  90                  95      


Leu Ser Gly Val Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 110     


<210>  38
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL3

<400>  38

Gln Ser Val Leu Thr Gln Pro Pro Ser Val Ser Gly Ala Pro Gly Gln 
1               5                   10                  15      


Arg Val Thr Ile Ser Cys Thr Gly Ser Asn Ser Asn Ile Gly Thr Gly 
            20                  25                  30          


Tyr Asp Val His Trp Tyr Gln Lys Leu Pro Gly Thr Ala Pro Arg Leu 
        35                  40                  45              


Leu Ile Tyr Ser His Phe Asn Arg Pro Ser Gly Val Pro Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Thr Ser Gly Thr Ser Ala Ser Leu Ala Ile Thr Gly Leu 
65                  70                  75                  80  


Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Gln Ser Tyr Asp Ser Ser 
                85                  90                  95      


Leu Ser Gly Ser Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 110     


<210>  39
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH1

<400>  39

Gln Val Gln Leu Gln Gln Trp Gly Ala Gly Leu Leu Lys Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Ala Val Tyr Gly Gly Ser Phe Ser Gly Tyr 
            20                  25                  30          


Tyr Trp Ser Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Glu Ile Asp His Ser Gly Arg Ile Asn Tyr Asn Pro Ala Leu Lys 
    50                  55                  60                  


Ser Arg Leu Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe Ser Leu 
65                  70                  75                  80  


Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Ala Gly Ser Gly Gly Tyr Glu Asp Trp Phe Asp Pro Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser 
        115                 120 


<210>  40
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH2

<400>  40

Gln Val Gln Leu Gln Gln Trp Gly Ala Gly Leu Leu Lys Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Ala Val Tyr Gly Gly Ser Phe Ser Gly Tyr 
            20                  25                  30          


Tyr Trp Ser Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Glu Ile Asp His Ser Gly Ser Thr Asn Tyr Asn Pro Ala Leu Lys 
    50                  55                  60                  


Ser Arg Leu Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe Ser Leu 
65                  70                  75                  80  


Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Ala Gly Ser Gly Gly Tyr Glu Asp Trp Phe Asp Pro Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser 
        115                 120 


<210>  41
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH3

<400>  41

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Trp Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Asn Ile Lys His Asp Gly Ser Glu Lys Tyr Tyr Val Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu His 
65                  70                  75                  80  


Leu Gln Met Ile Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Arg Tyr Ser Gly Gly Trp Thr Phe Phe Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser 
        115                 120 


<210>  42
<211>  118
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH4

<400>  42

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asp Tyr 
            20                  25                  30          


Tyr Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Asn Pro Asn Ser Gly Gly Thr Asn Tyr Val Gln Lys Phe 
    50                  55                  60                  


Gln Asp Arg Val Thr Met Thr Arg Asp Thr Ser Ile Thr Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Thr Arg Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Glu Glu Gly Asp Tyr Gly Met Asp Val Trp Gly Gln Gly Thr 
            100                 105                 110         


Thr Val Thr Val Ser Ser 
        115             


<210>  43
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRH1-1

<400>  43

Gly Tyr Tyr Trp Ser 
1               5   


<210>  44
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRH1-2

<400>  44

Ser Tyr Trp Met Ser 
1               5   


<210>  45
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRH1-3

<400>  45

Asp Tyr Tyr Met His 
1               5   


<210>  46
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRH2-1

<400>  46

Glu Ile Asp His Ser Gly Arg Ile Asn Tyr Asn Pro Ala Leu Lys Ser 
1               5                   10                  15      


<210>  47
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRH2-2

<400>  47

Glu Ile Asp His Ser Gly Ser Thr Asn Tyr Asn Pro Ala Leu Lys Ser 
1               5                   10                  15      


<210>  48
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRH2-3

<400>  48

Asn Ile Lys His Asp Gly Ser Glu Lys Tyr Tyr Val Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  49
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRH2-4

<400>  49

Trp Ile Asn Pro Asn Ser Gly Gly Thr Asn Tyr Val Gln Lys Phe Gln 
1               5                   10                  15      


Asp 
    


<210>  50
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRH3-1

<400>  50

Ala Gly Ser Gly Gly Tyr Glu Asp Trp Phe Asp Pro 
1               5                   10          


<210>  51
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRH3-2

<400>  51

Arg Tyr Ser Gly Gly Trp Thr Phe Phe Asp Tyr 
1               5                   10      


<210>  52
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRH3-3

<400>  52

Glu Glu Gly Asp Tyr Gly Met Asp Val 
1               5                   


<210>  53
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRL1-1

<400>  53

Thr Gly Ser Ser Ser Asn Ile Gly Ala Gly Tyr Asn Val His 
1               5                   10                  


<210>  54
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRL1-2

<400>  54

Thr Gly Ser Ser Ser Asn Ile Gly Thr Gly Tyr Asn Val His 
1               5                   10                  


<210>  55
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRL1-3

<400>  55

Thr Gly Ser Asn Ser Asn Ile Gly Thr Gly Tyr Asp Val His 
1               5                   10                  


<210>  56
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRL2-1

<400>  56

Val Tyr Asn Ile Arg Pro Ser 
1               5           


<210>  57
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRL2-2

<400>  57

Ser His Phe Asn Arg Pro Ser 
1               5           


<210>  58
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRL3-1

<400>  58

Gln Ser Tyr Asp Ser Ser Leu Ser Gly Val Val 
1               5                   10      


<210>  59
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRL3-2

<400>  59

Gln Ser Tyr Asp Ser Ser Leu Ser Gly Ser Val 
1               5                   10      


<210>  60
<211>  765
<212>  DNA
<213>  Homo sapiens


<220>
<221>  misc_feature
<223>  ORAI2 (NCBI Reference sequence NM_032831)

<220>
<221>  CDS
<222>  (1)..(765)

<400>  60
atg agt gct gag ctt aac gtg cct atc gac ccc tct gct cct gcc tgc         48
Met Ser Ala Glu Leu Asn Val Pro Ile Asp Pro Ser Ala Pro Ala Cys           
1               5                   10                  15                

cct gag ccc ggc cat aag ggc atg gat tac cgg gac tgg gtc cgc cgc         96
Pro Glu Pro Gly His Lys Gly Met Asp Tyr Arg Asp Trp Val Arg Arg           
            20                  25                  30                    

agc tac ctg gaa ctg gtc acc tct aac cac cac tcg gta cag gcc ctg        144
Ser Tyr Leu Glu Leu Val Thr Ser Asn His His Ser Val Gln Ala Leu           
        35                  40                  45                        

tcg tgg cgg aag ctc tac ctg agc agg gcc aag ctg aag gcc tcc agc        192
Ser Trp Arg Lys Leu Tyr Leu Ser Arg Ala Lys Leu Lys Ala Ser Ser           
    50                  55                  60                            

agg acc tcc gcc ctc ctc tcc ggc ttt gcc atg gtg gcc atg gtg gag        240
Arg Thr Ser Ala Leu Leu Ser Gly Phe Ala Met Val Ala Met Val Glu           
65                  70                  75                  80            

gtg cag ctg gag acg cag tac cag tac ccg cgg ccg ctg ctg att gcc        288
Val Gln Leu Glu Thr Gln Tyr Gln Tyr Pro Arg Pro Leu Leu Ile Ala           
                85                  90                  95                

ttc agc gcc tgc acc acg gtg ctg gtg gcc gtg cac ctg ttc gcc ctc        336
Phe Ser Ala Cys Thr Thr Val Leu Val Ala Val His Leu Phe Ala Leu           
            100                 105                 110                   

ctc atc agc acc tgc atc ctg ccc aat gtg gag gcc gtg agc aac atc        384
Leu Ile Ser Thr Cys Ile Leu Pro Asn Val Glu Ala Val Ser Asn Ile           
        115                 120                 125                       

cac aac ctg aac tcc atc agc gag tcc ccg cat gag cgc atg cac ccc        432
His Asn Leu Asn Ser Ile Ser Glu Ser Pro His Glu Arg Met His Pro           
    130                 135                 140                           

tac atc gag ctg gcc tgg ggc ttc tcc acc gtg ctt ggc atc cta ctc        480
Tyr Ile Glu Leu Ala Trp Gly Phe Ser Thr Val Leu Gly Ile Leu Leu           
145                 150                 155                 160           

ttc ctg gcc gag gtg gtg ctg ctc tgc tgg atc aag ttc ctc ccc gtg        528
Phe Leu Ala Glu Val Val Leu Leu Cys Trp Ile Lys Phe Leu Pro Val           
                165                 170                 175               

gat gcc cgg cgc cag cct ggc ccc cca cct ggc cct ggg agt cac acg        576
Asp Ala Arg Arg Gln Pro Gly Pro Pro Pro Gly Pro Gly Ser His Thr           
            180                 185                 190                   

ggc tgg cag gcc gcc ctg gtg tcc acc atc atc atg gtg ccc gtg ggc        624
Gly Trp Gln Ala Ala Leu Val Ser Thr Ile Ile Met Val Pro Val Gly           
        195                 200                 205                       

ctc atc ttc gtg gtc ttc acc atc cac ttc tac cgc tcc ctg gtg cgc        672
Leu Ile Phe Val Val Phe Thr Ile His Phe Tyr Arg Ser Leu Val Arg           
    210                 215                 220                           

cac aaa acg gag cgc cac aac cgc gag atc gag gag ctc cac aag ctc        720
His Lys Thr Glu Arg His Asn Arg Glu Ile Glu Glu Leu His Lys Leu           
225                 230                 235                 240           

aag gtc cag ctg gac ggg cat gag cgc agc ctg cag gtc ttg tga            765
Lys Val Gln Leu Asp Gly His Glu Arg Ser Leu Gln Val Leu                   
                245                 250                                   


<210>  61
<211>  254
<212>  PRT
<213>  Homo sapiens

<400>  61

Met Ser Ala Glu Leu Asn Val Pro Ile Asp Pro Ser Ala Pro Ala Cys 
1               5                   10                  15      


Pro Glu Pro Gly His Lys Gly Met Asp Tyr Arg Asp Trp Val Arg Arg 
            20                  25                  30          


Ser Tyr Leu Glu Leu Val Thr Ser Asn His His Ser Val Gln Ala Leu 
        35                  40                  45              


Ser Trp Arg Lys Leu Tyr Leu Ser Arg Ala Lys Leu Lys Ala Ser Ser 
    50                  55                  60                  


Arg Thr Ser Ala Leu Leu Ser Gly Phe Ala Met Val Ala Met Val Glu 
65                  70                  75                  80  


Val Gln Leu Glu Thr Gln Tyr Gln Tyr Pro Arg Pro Leu Leu Ile Ala 
                85                  90                  95      


Phe Ser Ala Cys Thr Thr Val Leu Val Ala Val His Leu Phe Ala Leu 
            100                 105                 110         


Leu Ile Ser Thr Cys Ile Leu Pro Asn Val Glu Ala Val Ser Asn Ile 
        115                 120                 125             


His Asn Leu Asn Ser Ile Ser Glu Ser Pro His Glu Arg Met His Pro 
    130                 135                 140                 


Tyr Ile Glu Leu Ala Trp Gly Phe Ser Thr Val Leu Gly Ile Leu Leu 
145                 150                 155                 160 


Phe Leu Ala Glu Val Val Leu Leu Cys Trp Ile Lys Phe Leu Pro Val 
                165                 170                 175     


Asp Ala Arg Arg Gln Pro Gly Pro Pro Pro Gly Pro Gly Ser His Thr 
            180                 185                 190         


Gly Trp Gln Ala Ala Leu Val Ser Thr Ile Ile Met Val Pro Val Gly 
        195                 200                 205             


Leu Ile Phe Val Val Phe Thr Ile His Phe Tyr Arg Ser Leu Val Arg 
    210                 215                 220                 


His Lys Thr Glu Arg His Asn Arg Glu Ile Glu Glu Leu His Lys Leu 
225                 230                 235                 240 


Lys Val Gln Leu Asp Gly His Glu Arg Ser Leu Gln Val Leu 
                245                 250                 


<210>  62
<211>  888
<212>  DNA
<213>  Homo sapiens


<220>
<221>  misc_feature
<223>  ORAI3 (NCBI Reference sequence NM_152288)

<220>
<221>  CDS
<222>  (1)..(888)

<400>  62
atg aag ggc ggc gag ggg gac gcg ggc gag cag gcc ccg ctg aac cct         48
Met Lys Gly Gly Glu Gly Asp Ala Gly Glu Gln Ala Pro Leu Asn Pro           
1               5                   10                  15                

gag ggc gag agc cct gca ggc tcg gcc acg tac cgg gag ttc gtg cac         96
Glu Gly Glu Ser Pro Ala Gly Ser Ala Thr Tyr Arg Glu Phe Val His           
            20                  25                  30                    

cgc ggc tac ctg gac ctc atg ggg gcc agt cag cac tcg ctg cgg gcg        144
Arg Gly Tyr Leu Asp Leu Met Gly Ala Ser Gln His Ser Leu Arg Ala           
        35                  40                  45                        

ctc agc tgg cgc cgc ctc tac ctc agc cgg gcc aag ctc aaa gct tcc        192
Leu Ser Trp Arg Arg Leu Tyr Leu Ser Arg Ala Lys Leu Lys Ala Ser           
    50                  55                  60                            

agc cgc acg tct gcc ttg ctc tcg ggc ttc gcc atg gtg gcc atg gtg        240
Ser Arg Thr Ser Ala Leu Leu Ser Gly Phe Ala Met Val Ala Met Val           
65                  70                  75                  80            

gag gtg cag ctg gag agt gac cac gag tac cca cca ggc ctg ctg gtg        288
Glu Val Gln Leu Glu Ser Asp His Glu Tyr Pro Pro Gly Leu Leu Val           
                85                  90                  95                

gcc ttc agt gcc tgc acc acc gtg ctg gtg gct gtg cac ctc ttt gca        336
Ala Phe Ser Ala Cys Thr Thr Val Leu Val Ala Val His Leu Phe Ala           
            100                 105                 110                   

ctc atg gtc tcc acg tgt ctg ctg ccc cac att gaa gct gtg agc aac        384
Leu Met Val Ser Thr Cys Leu Leu Pro His Ile Glu Ala Val Ser Asn           
        115                 120                 125                       

atc cac aac ctc aac tct gtc cac cag tcg cca cac cag aga ctg cac        432
Ile His Asn Leu Asn Ser Val His Gln Ser Pro His Gln Arg Leu His           
    130                 135                 140                           

cgc tac gtg gag ctg gcc tgg ggc ttc tcc act gcc ctg ggc acc ttt        480
Arg Tyr Val Glu Leu Ala Trp Gly Phe Ser Thr Ala Leu Gly Thr Phe           
145                 150                 155                 160           

ctc ttc ctt gct gaa gtt gtc ctg gtt ggt tgg gtc aag ttt gtg ccc        528
Leu Phe Leu Ala Glu Val Val Leu Val Gly Trp Val Lys Phe Val Pro           
                165                 170                 175               

att ggg gct ccc ttg gac aca ccg acc ccc atg gtg ccc aca tcc cgg        576
Ile Gly Ala Pro Leu Asp Thr Pro Thr Pro Met Val Pro Thr Ser Arg           
            180                 185                 190                   

gtg ccc ggg act ctg gca cca gtg gct acc tcc ctt agt cca gct tcc        624
Val Pro Gly Thr Leu Ala Pro Val Ala Thr Ser Leu Ser Pro Ala Ser           
        195                 200                 205                       

aat ctc cca cgg tcc tct gcg tct gca gca ccg tcc cag gct gag cca        672
Asn Leu Pro Arg Ser Ser Ala Ser Ala Ala Pro Ser Gln Ala Glu Pro           
    210                 215                 220                           

gcc tgc cca ccc cgg caa gcc tgt ggt ggt ggt ggg gcc cat ggg cca        720
Ala Cys Pro Pro Arg Gln Ala Cys Gly Gly Gly Gly Ala His Gly Pro           
225                 230                 235                 240           

ggc tgg caa gca gcc atg gcc tcc aca gcc atc atg gta ccc gtg ggg        768
Gly Trp Gln Ala Ala Met Ala Ser Thr Ala Ile Met Val Pro Val Gly           
                245                 250                 255               

ctc gtg ttt gtg gcc ttt gcc ctg cat ttc tac cgc tcc ttg gtg gca        816
Leu Val Phe Val Ala Phe Ala Leu His Phe Tyr Arg Ser Leu Val Ala           
            260                 265                 270                   

cac aag aca gac cgc tac aag cag gaa cta gag gaa ctg aat cgc ctg        864
His Lys Thr Asp Arg Tyr Lys Gln Glu Leu Glu Glu Leu Asn Arg Leu           
        275                 280                 285                       

cag ggg gag ctg cag gct gtg tga                                        888
Gln Gly Glu Leu Gln Ala Val                                               
    290                 295                                               


<210>  63
<211>  295
<212>  PRT
<213>  Homo sapiens

<400>  63

Met Lys Gly Gly Glu Gly Asp Ala Gly Glu Gln Ala Pro Leu Asn Pro 
1               5                   10                  15      


Glu Gly Glu Ser Pro Ala Gly Ser Ala Thr Tyr Arg Glu Phe Val His 
            20                  25                  30          


Arg Gly Tyr Leu Asp Leu Met Gly Ala Ser Gln His Ser Leu Arg Ala 
        35                  40                  45              


Leu Ser Trp Arg Arg Leu Tyr Leu Ser Arg Ala Lys Leu Lys Ala Ser 
    50                  55                  60                  


Ser Arg Thr Ser Ala Leu Leu Ser Gly Phe Ala Met Val Ala Met Val 
65                  70                  75                  80  


Glu Val Gln Leu Glu Ser Asp His Glu Tyr Pro Pro Gly Leu Leu Val 
                85                  90                  95      


Ala Phe Ser Ala Cys Thr Thr Val Leu Val Ala Val His Leu Phe Ala 
            100                 105                 110         


Leu Met Val Ser Thr Cys Leu Leu Pro His Ile Glu Ala Val Ser Asn 
        115                 120                 125             


Ile His Asn Leu Asn Ser Val His Gln Ser Pro His Gln Arg Leu His 
    130                 135                 140                 


Arg Tyr Val Glu Leu Ala Trp Gly Phe Ser Thr Ala Leu Gly Thr Phe 
145                 150                 155                 160 


Leu Phe Leu Ala Glu Val Val Leu Val Gly Trp Val Lys Phe Val Pro 
                165                 170                 175     


Ile Gly Ala Pro Leu Asp Thr Pro Thr Pro Met Val Pro Thr Ser Arg 
            180                 185                 190         


Val Pro Gly Thr Leu Ala Pro Val Ala Thr Ser Leu Ser Pro Ala Ser 
        195                 200                 205             


Asn Leu Pro Arg Ser Ser Ala Ser Ala Ala Pro Ser Gln Ala Glu Pro 
    210                 215                 220                 


Ala Cys Pro Pro Arg Gln Ala Cys Gly Gly Gly Gly Ala His Gly Pro 
225                 230                 235                 240 


Gly Trp Gln Ala Ala Met Ala Ser Thr Ala Ile Met Val Pro Val Gly 
                245                 250                 255     


Leu Val Phe Val Ala Phe Ala Leu His Phe Tyr Arg Ser Leu Val Ala 
            260                 265                 270         


His Lys Thr Asp Arg Tyr Lys Gln Glu Leu Glu Glu Leu Asn Arg Leu 
        275                 280                 285             


Gln Gly Glu Leu Gln Ala Val 
    290                 295 


<210>  64
<211>  906
<212>  DNA
<213>  Homo sapiens


<220>
<221>  misc_feature
<223>  ORAI1 (S218G) coding sequence

<220>
<221>  CDS
<222>  (1)..(906)

<400>  64
atg cat ccg gag ccc gcc ccg ccc ccg agc cgc agc agt ccc gag ctt         48
Met His Pro Glu Pro Ala Pro Pro Pro Ser Arg Ser Ser Pro Glu Leu           
1               5                   10                  15                

ccc cca agc ggc ggc agc acc acc agc ggc agc cgc cgg agc cgc cgc         96
Pro Pro Ser Gly Gly Ser Thr Thr Ser Gly Ser Arg Arg Ser Arg Arg           
            20                  25                  30                    

cgc agc ggg gac ggg gag ccc ccg ggg gcc ccg cca ccg ccg ccg tcc        144
Arg Ser Gly Asp Gly Glu Pro Pro Gly Ala Pro Pro Pro Pro Pro Ser           
        35                  40                  45                        

gcc gtc acc tac ccg gac tgg atc ggc cag agt tac tcc gag gtg atg        192
Ala Val Thr Tyr Pro Asp Trp Ile Gly Gln Ser Tyr Ser Glu Val Met           
    50                  55                  60                            

agc ctc aac gag cac tcc atg cag gcg ctg tcc tgg cgc aag ctc tac        240
Ser Leu Asn Glu His Ser Met Gln Ala Leu Ser Trp Arg Lys Leu Tyr           
65                  70                  75                  80            

ttg agc cgc gcc aag ctt aaa gcc tcc agc cgg acc tcg gct ctg ctc        288
Leu Ser Arg Ala Lys Leu Lys Ala Ser Ser Arg Thr Ser Ala Leu Leu           
                85                  90                  95                

tcc ggc ttc gcc atg gtg gca atg gtg gag gtg cag ctg gac gct gac        336
Ser Gly Phe Ala Met Val Ala Met Val Glu Val Gln Leu Asp Ala Asp           
            100                 105                 110                   

cac gac tac cca ccg ggg ctg ctc atc gcc ttc agt gcc tgc acc aca        384
His Asp Tyr Pro Pro Gly Leu Leu Ile Ala Phe Ser Ala Cys Thr Thr           
        115                 120                 125                       

gtg ctg gtg gct gtg cac ctg ttt gcg ctc atg atc agc acc tgc atc        432
Val Leu Val Ala Val His Leu Phe Ala Leu Met Ile Ser Thr Cys Ile           
    130                 135                 140                           

ctg ccc aac atc gag gcg gtg agc aac gtg cac aat ctc aac tcg gtc        480
Leu Pro Asn Ile Glu Ala Val Ser Asn Val His Asn Leu Asn Ser Val           
145                 150                 155                 160           

aag gag tcc ccc cat gag cgc atg cac cgc cac atc gag ctg gcc tgg        528
Lys Glu Ser Pro His Glu Arg Met His Arg His Ile Glu Leu Ala Trp           
                165                 170                 175               

gcc ttc tcc acc gtc atc ggc acg ctg ctc ttc cta gct gag gtg gtg        576
Ala Phe Ser Thr Val Ile Gly Thr Leu Leu Phe Leu Ala Glu Val Val           
            180                 185                 190                   

ctg ctc tgc tgg gtc aag ttc ttg ccc ctc aag aag cag cca ggc cag        624
Leu Leu Cys Trp Val Lys Phe Leu Pro Leu Lys Lys Gln Pro Gly Gln           
        195                 200                 205                       

cca agg ccc acc agc aag ccc ccc gcc ggt ggc gca gca gcc aac gtc        672
Pro Arg Pro Thr Ser Lys Pro Pro Ala Gly Gly Ala Ala Ala Asn Val           
    210                 215                 220                           

agc acc agc ggc atc acc ccg ggc cag gca gct gcc atc gcc tcg acc        720
Ser Thr Ser Gly Ile Thr Pro Gly Gln Ala Ala Ala Ile Ala Ser Thr           
225                 230                 235                 240           

acc atc atg gtg ccc ttc ggc ctg atc ttt atc gtc ttc gcc gtc cac        768
Thr Ile Met Val Pro Phe Gly Leu Ile Phe Ile Val Phe Ala Val His           
                245                 250                 255               

ttc tac cgc tca ctg gtt agc cat aag act gac cga cag ttc cag gag        816
Phe Tyr Arg Ser Leu Val Ser His Lys Thr Asp Arg Gln Phe Gln Glu           
            260                 265                 270                   

ctc aac gag ctg gcg gag ttt gcc cgc tta cag gac cag ctg gac cac        864
Leu Asn Glu Leu Ala Glu Phe Ala Arg Leu Gln Asp Gln Leu Asp His           
        275                 280                 285                       

aga ggg gac cac ccc ctg acg ccc ggc agc cac tat gcc tag                906
Arg Gly Asp His Pro Leu Thr Pro Gly Ser His Tyr Ala                       
    290                 295                 300                           


<210>  65
<211>  301
<212>  PRT
<213>  Homo sapiens

<400>  65

Met His Pro Glu Pro Ala Pro Pro Pro Ser Arg Ser Ser Pro Glu Leu 
1               5                   10                  15      


Pro Pro Ser Gly Gly Ser Thr Thr Ser Gly Ser Arg Arg Ser Arg Arg 
            20                  25                  30          


Arg Ser Gly Asp Gly Glu Pro Pro Gly Ala Pro Pro Pro Pro Pro Ser 
        35                  40                  45              


Ala Val Thr Tyr Pro Asp Trp Ile Gly Gln Ser Tyr Ser Glu Val Met 
    50                  55                  60                  


Ser Leu Asn Glu His Ser Met Gln Ala Leu Ser Trp Arg Lys Leu Tyr 
65                  70                  75                  80  


Leu Ser Arg Ala Lys Leu Lys Ala Ser Ser Arg Thr Ser Ala Leu Leu 
                85                  90                  95      


Ser Gly Phe Ala Met Val Ala Met Val Glu Val Gln Leu Asp Ala Asp 
            100                 105                 110         


His Asp Tyr Pro Pro Gly Leu Leu Ile Ala Phe Ser Ala Cys Thr Thr 
        115                 120                 125             


Val Leu Val Ala Val His Leu Phe Ala Leu Met Ile Ser Thr Cys Ile 
    130                 135                 140                 


Leu Pro Asn Ile Glu Ala Val Ser Asn Val His Asn Leu Asn Ser Val 
145                 150                 155                 160 


Lys Glu Ser Pro His Glu Arg Met His Arg His Ile Glu Leu Ala Trp 
                165                 170                 175     


Ala Phe Ser Thr Val Ile Gly Thr Leu Leu Phe Leu Ala Glu Val Val 
            180                 185                 190         


Leu Leu Cys Trp Val Lys Phe Leu Pro Leu Lys Lys Gln Pro Gly Gln 
        195                 200                 205             


Pro Arg Pro Thr Ser Lys Pro Pro Ala Gly Gly Ala Ala Ala Asn Val 
    210                 215                 220                 


Ser Thr Ser Gly Ile Thr Pro Gly Gln Ala Ala Ala Ile Ala Ser Thr 
225                 230                 235                 240 


Thr Ile Met Val Pro Phe Gly Leu Ile Phe Ile Val Phe Ala Val His 
                245                 250                 255     


Phe Tyr Arg Ser Leu Val Ser His Lys Thr Asp Arg Gln Phe Gln Glu 
            260                 265                 270         


Leu Asn Glu Leu Ala Glu Phe Ala Arg Leu Gln Asp Gln Leu Asp His 
        275                 280                 285             


Arg Gly Asp His Pro Leu Thr Pro Gly Ser His Tyr Ala 
    290                 295                 300     


<210>  66
<211>  43
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Forward primer sequence

<400>  66
ccaccagcaa gccccccgcc ggtggcgcag cagccaacgt cag                         43


<210>  67
<211>  42
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Reverse primer sequence

<400>  67
ctgacgttgg ctgctgcgcc accggcgggg ggcttgctgg tg                          42


<210>  68
<211>  38
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Forward primer sequence

<400>  68
ggatcctgaa ccaccatgca tccggagcct gccccgcc                               38


<210>  69
<211>  31
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Reverse primer sequence

<400>  69
gcggccgctt aggcatagtg ggtgcccggt g                                      31


<210>  70
<211>  36
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<223>  Putative ORAI1 (S218G) ECL2 domain sequence

<400>  70

Lys Phe Leu Pro Leu Lys Lys Gln Pro Gly Gln Pro Arg Pro Thr Ser 
1               5                   10                  15      


Lys Pro Pro Ala Gly Gly Ala Ala Ala Asn Val Ser Thr Ser Gly Ile 
            20                  25                  30          


Thr Pro Gly Gln 
        35      


<210>  71
<211>  915
<212>  DNA
<213>  Mus musculus


<220>
<221>  misc_feature
<223>  ORAI1-NCBI reference sequence NM_1754 23

<220>
<221>  CDS
<222>  (1)..(915)

<400>  71
atg cat ccg gag cct gcc ccg ccc ccg agt cac agc aat ccg gag ctt         48
Met His Pro Glu Pro Ala Pro Pro Pro Ser His Ser Asn Pro Glu Leu           
1               5                   10                  15                

ccc gtg agc ggc ggc agc agc act agc ggc agc cgc cgg agc cgc cgc         96
Pro Val Ser Gly Gly Ser Ser Thr Ser Gly Ser Arg Arg Ser Arg Arg           
            20                  25                  30                    

cgc agc ggg gac ggg gag ccc tcg ggg gcc cca ccg ctg ccg ccg ccg        144
Arg Ser Gly Asp Gly Glu Pro Ser Gly Ala Pro Pro Leu Pro Pro Pro           
        35                  40                  45                        

cca ccc gcc gtc agc tac ccg gac tgg atc ggc cag agt tac tcc gag        192
Pro Pro Ala Val Ser Tyr Pro Asp Trp Ile Gly Gln Ser Tyr Ser Glu           
    50                  55                  60                            

gtg atg agc ctc aac gag cac tcg atg cag gcg ctg tcc tgg cgc aag        240
Val Met Ser Leu Asn Glu His Ser Met Gln Ala Leu Ser Trp Arg Lys           
65                  70                  75                  80            

ctc tac tta agc cgc gcc aag ctc aaa gct tcc agc cgg acc tcg gct        288
Leu Tyr Leu Ser Arg Ala Lys Leu Lys Ala Ser Ser Arg Thr Ser Ala           
                85                  90                  95                

ctg ctc tcc ggc ttc gcc atg gta gcg atg gtg gaa gtc cag ctg gac        336
Leu Leu Ser Gly Phe Ala Met Val Ala Met Val Glu Val Gln Leu Asp           
            100                 105                 110                   

aca gac cat gac tac cca cca ggg ttg ctc atc gtc ttt agt gcc tgc        384
Thr Asp His Asp Tyr Pro Pro Gly Leu Leu Ile Val Phe Ser Ala Cys           
        115                 120                 125                       

acc aca gtg cta gtg gcc gtg cac ctg ttt gcc ctc atg atc agc acc        432
Thr Thr Val Leu Val Ala Val His Leu Phe Ala Leu Met Ile Ser Thr           
    130                 135                 140                           

tgc atc ctg ccc aac atc gag gct gtg agc aac gtc cac aac ctc aac        480
Cys Ile Leu Pro Asn Ile Glu Ala Val Ser Asn Val His Asn Leu Asn           
145                 150                 155                 160           

tcg gtc aaa gag tca ccc cac gag cgc atg cat cgc cac atc gag ctg        528
Ser Val Lys Glu Ser Pro His Glu Arg Met His Arg His Ile Glu Leu           
                165                 170                 175               

gcc tgg gcc ttc tcc acg gtc atc ggg acg ctg ctt ttc cta gca gag        576
Ala Trp Ala Phe Ser Thr Val Ile Gly Thr Leu Leu Phe Leu Ala Glu           
            180                 185                 190                   

gtc gtg ctg ctc tgc tgg gtc aag ttc tta cct ctc aag agg caa gcg        624
Val Val Leu Leu Cys Trp Val Lys Phe Leu Pro Leu Lys Arg Gln Ala           
        195                 200                 205                       

gga cag cca agc ccc acc aag cct ccc gct gaa tca gtc atc gtc gcc        672
Gly Gln Pro Ser Pro Thr Lys Pro Pro Ala Glu Ser Val Ile Val Ala           
    210                 215                 220                           

aac cac agc gac agc agc ggc atc acc ccg ggt gag gcg gca gcc att        720
Asn His Ser Asp Ser Ser Gly Ile Thr Pro Gly Glu Ala Ala Ala Ile           
225                 230                 235                 240           

gcc tcc acc gcc atc atg gtt ccc tgt ggc ctg gtt ttt atc gtc ttt        768
Ala Ser Thr Ala Ile Met Val Pro Cys Gly Leu Val Phe Ile Val Phe           
                245                 250                 255               

gct gtt cac ttc tac cgc tcc ctg gtc agc cat aag acg gac cgg cag        816
Ala Val His Phe Tyr Arg Ser Leu Val Ser His Lys Thr Asp Arg Gln           
            260                 265                 270                   

ttc cag gag ctc aat gag ctg gcc gag ttt gcc cgc ttg cag gac cag        864
Phe Gln Glu Leu Asn Glu Leu Ala Glu Phe Ala Arg Leu Gln Asp Gln           
        275                 280                 285                       

ctg gac cac aga ggg gac cat tct cta aca ccg ggc acc cac tat gcc        912
Leu Asp His Arg Gly Asp His Ser Leu Thr Pro Gly Thr His Tyr Ala           
    290                 295                 300                           

tag                                                                    915


<210>  72
<211>  304
<212>  PRT
<213>  Mus musculus

<400>  72

Met His Pro Glu Pro Ala Pro Pro Pro Ser His Ser Asn Pro Glu Leu 
1               5                   10                  15      


Pro Val Ser Gly Gly Ser Ser Thr Ser Gly Ser Arg Arg Ser Arg Arg 
            20                  25                  30          


Arg Ser Gly Asp Gly Glu Pro Ser Gly Ala Pro Pro Leu Pro Pro Pro 
        35                  40                  45              


Pro Pro Ala Val Ser Tyr Pro Asp Trp Ile Gly Gln Ser Tyr Ser Glu 
    50                  55                  60                  


Val Met Ser Leu Asn Glu His Ser Met Gln Ala Leu Ser Trp Arg Lys 
65                  70                  75                  80  


Leu Tyr Leu Ser Arg Ala Lys Leu Lys Ala Ser Ser Arg Thr Ser Ala 
                85                  90                  95      


Leu Leu Ser Gly Phe Ala Met Val Ala Met Val Glu Val Gln Leu Asp 
            100                 105                 110         


Thr Asp His Asp Tyr Pro Pro Gly Leu Leu Ile Val Phe Ser Ala Cys 
        115                 120                 125             


Thr Thr Val Leu Val Ala Val His Leu Phe Ala Leu Met Ile Ser Thr 
    130                 135                 140                 


Cys Ile Leu Pro Asn Ile Glu Ala Val Ser Asn Val His Asn Leu Asn 
145                 150                 155                 160 


Ser Val Lys Glu Ser Pro His Glu Arg Met His Arg His Ile Glu Leu 
                165                 170                 175     


Ala Trp Ala Phe Ser Thr Val Ile Gly Thr Leu Leu Phe Leu Ala Glu 
            180                 185                 190         


Val Val Leu Leu Cys Trp Val Lys Phe Leu Pro Leu Lys Arg Gln Ala 
        195                 200                 205             


Gly Gln Pro Ser Pro Thr Lys Pro Pro Ala Glu Ser Val Ile Val Ala 
    210                 215                 220                 


Asn His Ser Asp Ser Ser Gly Ile Thr Pro Gly Glu Ala Ala Ala Ile 
225                 230                 235                 240 


Ala Ser Thr Ala Ile Met Val Pro Cys Gly Leu Val Phe Ile Val Phe 
                245                 250                 255     


Ala Val His Phe Tyr Arg Ser Leu Val Ser His Lys Thr Asp Arg Gln 
            260                 265                 270         


Phe Gln Glu Leu Asn Glu Leu Ala Glu Phe Ala Arg Leu Gln Asp Gln 
        275                 280                 285             


Leu Asp His Arg Gly Asp His Ser Leu Thr Pro Gly Thr His Tyr Ala 
    290                 295                 300                 


<210>  73
<211>  2058
<212>  DNA
<213>  Mus musculus


<220>
<221>  misc_feature
<223>  STIM1-NCBI reference sequence NM_009 287

<220>
<221>  CDS
<222>  (1)..(2058)

<400>  73
atg gat gtg tgc gcc cgt ctt gcc ctg tgg ctt ctt tgg ggg ctc ctt         48
Met Asp Val Cys Ala Arg Leu Ala Leu Trp Leu Leu Trp Gly Leu Leu           
1               5                   10                  15                

ctg cat cag ggc cag agt ctc agc cat agt cac agt gaa aag aat aca         96
Leu His Gln Gly Gln Ser Leu Ser His Ser His Ser Glu Lys Asn Thr           
            20                  25                  30                    

gga gct agc tcc ggg gcg act tct gaa gag tct acc gaa gca gag ttt        144
Gly Ala Ser Ser Gly Ala Thr Ser Glu Glu Ser Thr Glu Ala Glu Phe           
        35                  40                  45                        

tgc cga att gac aag ccc ctg tgc cac agt gag gat gag aag ctc agc        192
Cys Arg Ile Asp Lys Pro Leu Cys His Ser Glu Asp Glu Lys Leu Ser           
    50                  55                  60                            

ttt gag gcc gtc cga aac atc cat aag ctg atg gat gac gat gcc aat        240
Phe Glu Ala Val Arg Asn Ile His Lys Leu Met Asp Asp Asp Ala Asn           
65                  70                  75                  80            

ggt gat gtg gat gtg gaa gaa agt gat gag ttc cta agg gaa gac ctc        288
Gly Asp Val Asp Val Glu Glu Ser Asp Glu Phe Leu Arg Glu Asp Leu           
                85                  90                  95                

aat tac cat gac cca aca gtg aaa cat agc acc ttc cat ggt gag gat        336
Asn Tyr His Asp Pro Thr Val Lys His Ser Thr Phe His Gly Glu Asp           
            100                 105                 110                   

aag ctt atc agc gtg gag gac ctg tgg aag gcg tgg aaa tca tca gaa        384
Lys Leu Ile Ser Val Glu Asp Leu Trp Lys Ala Trp Lys Ser Ser Glu           
        115                 120                 125                       

gtg tac aac tgg act gtg gat gag gtg ata cag tgg ctc att acg tat        432
Val Tyr Asn Trp Thr Val Asp Glu Val Ile Gln Trp Leu Ile Thr Tyr           
    130                 135                 140                           

gtg gag ctg cca cag tat gag gag acc ttc cgg aag ttg cag ctt act        480
Val Glu Leu Pro Gln Tyr Glu Glu Thr Phe Arg Lys Leu Gln Leu Thr           
145                 150                 155                 160           

ggc cac gcc atg cca agg cta gca gta acc aac acc acc atg aca ggg        528
Gly His Ala Met Pro Arg Leu Ala Val Thr Asn Thr Thr Met Thr Gly           
                165                 170                 175               

act gta ctg aag atg aca gat cgg agc cac agg cag aag ctg cag ctg        576
Thr Val Leu Lys Met Thr Asp Arg Ser His Arg Gln Lys Leu Gln Leu           
            180                 185                 190                   

aag gcc ctg gac aca gtg ctg ttt ggg cct cct ctc ttg act cgg cat        624
Lys Ala Leu Asp Thr Val Leu Phe Gly Pro Pro Leu Leu Thr Arg His           
        195                 200                 205                       

aat cac ctg aag gac ttc atg ctg gtg gtg tct atc gtt att ggt gtg        672
Asn His Leu Lys Asp Phe Met Leu Val Val Ser Ile Val Ile Gly Val           
    210                 215                 220                           

ggt ggc tgc tgg ttt gcc tat atc cag aac cgt tac tct aag gag cac        720
Gly Gly Cys Trp Phe Ala Tyr Ile Gln Asn Arg Tyr Ser Lys Glu His           
225                 230                 235                 240           

atg aag aaa atg atg aag gat ctg gaa ggg tta cac cgg gct gag cag        768
Met Lys Lys Met Met Lys Asp Leu Glu Gly Leu His Arg Ala Glu Gln           
                245                 250                 255               

agt ctg cat gac ctt cag gaa agg ctg cac aag gcc cag gag gag cac        816
Ser Leu His Asp Leu Gln Glu Arg Leu His Lys Ala Gln Glu Glu His           
            260                 265                 270                   

cga act gtg gaa gta gag aaa gtc cac ctg gag aag aag ctg cga gat        864
Arg Thr Val Glu Val Glu Lys Val His Leu Glu Lys Lys Leu Arg Asp           
        275                 280                 285                       

gag atc aac ctt gcc aag cag gaa gct cag cgg ctg aag gag ctg agg        912
Glu Ile Asn Leu Ala Lys Gln Glu Ala Gln Arg Leu Lys Glu Leu Arg           
    290                 295                 300                           

gag ggt act gag aat gag agg agc cgt caa aaa tat gct gag gaa gag        960
Glu Gly Thr Glu Asn Glu Arg Ser Arg Gln Lys Tyr Ala Glu Glu Glu           
305                 310                 315                 320           

ctg gag cag gtt cgg gag gcc ttg agg aaa gca gag aag gag ctg gaa       1008
Leu Glu Gln Val Arg Glu Ala Leu Arg Lys Ala Glu Lys Glu Leu Glu           
                325                 330                 335               

tca cac agc tca tgg tat gct cct gag gcc ctg cag aag tgg ctg cag       1056
Ser His Ser Ser Trp Tyr Ala Pro Glu Ala Leu Gln Lys Trp Leu Gln           
            340                 345                 350                   

ctg acc cat gag gtg gag gtg cag tac tac aac atc aag aag caa aat       1104
Leu Thr His Glu Val Glu Val Gln Tyr Tyr Asn Ile Lys Lys Gln Asn           
        355                 360                 365                       

gca gag agg cag ctg ctg gtg gcc aag gag ggg gct gag aaa ata aaa       1152
Ala Glu Arg Gln Leu Leu Val Ala Lys Glu Gly Ala Glu Lys Ile Lys           
    370                 375                 380                           

aag aag aga aac acg ctt ttt ggt acc ttc cat gtg gcc cac agc tct       1200
Lys Lys Arg Asn Thr Leu Phe Gly Thr Phe His Val Ala His Ser Ser           
385                 390                 395                 400           

tcc ctg gat gat gtg gat cat aaa atc cta act gct aag caa gct ctg       1248
Ser Leu Asp Asp Val Asp His Lys Ile Leu Thr Ala Lys Gln Ala Leu           
                405                 410                 415               

agt gag gtg aca gcg gca ctg agg gag cgc ctg cac cgg tgg cag cag       1296
Ser Glu Val Thr Ala Ala Leu Arg Glu Arg Leu His Arg Trp Gln Gln           
            420                 425                 430                   

atc gag atc ctc tgc ggt ttc cag att gtc aat aac ccc ggc atc cac       1344
Ile Glu Ile Leu Cys Gly Phe Gln Ile Val Asn Asn Pro Gly Ile His           
        435                 440                 445                       

tcc ttg gtg gct gct ctc aac atc gac ccc agc tgg atg ggc agc acc       1392
Ser Leu Val Ala Ala Leu Asn Ile Asp Pro Ser Trp Met Gly Ser Thr           
    450                 455                 460                           

cgc cct aac ccc gcc cac ttc atc atg act gac gat gtg gat gac atg       1440
Arg Pro Asn Pro Ala His Phe Ile Met Thr Asp Asp Val Asp Asp Met           
465                 470                 475                 480           

gat gag gag att gtg tcg ccc ttg tcc atg cag tcc ccc agc ctg cag       1488
Asp Glu Glu Ile Val Ser Pro Leu Ser Met Gln Ser Pro Ser Leu Gln           
                485                 490                 495               

agc agt gtc cgg cag cgc ctg acg gag cca cag ctt ggc ctg gga tct       1536
Ser Ser Val Arg Gln Arg Leu Thr Glu Pro Gln Leu Gly Leu Gly Ser           
            500                 505                 510                   

cag agg gat ttg acc cat tcc gat tcg gag tcc tcc ctc cac atg agt       1584
Gln Arg Asp Leu Thr His Ser Asp Ser Glu Ser Ser Leu His Met Ser           
        515                 520                 525                       

gac cgc cag cgt gtg gcc ccc aag cct cct cag atg ggc cgt gct gca       1632
Asp Arg Gln Arg Val Ala Pro Lys Pro Pro Gln Met Gly Arg Ala Ala           
    530                 535                 540                           

gat gaa gct ctc aat gcc atg cct tcc aat ggc agc cat cgg ctg att       1680
Asp Glu Ala Leu Asn Ala Met Pro Ser Asn Gly Ser His Arg Leu Ile           
545                 550                 555                 560           

gag ggg gtc cat cca gga tct ctg gtg gag aaa ctg cct gac agc cct       1728
Glu Gly Val His Pro Gly Ser Leu Val Glu Lys Leu Pro Asp Ser Pro           
                565                 570                 575               

gct ctg gcc aag aag aca ttt atg gcg ttg aac cat ggc cta gac aag       1776
Ala Leu Ala Lys Lys Thr Phe Met Ala Leu Asn His Gly Leu Asp Lys           
            580                 585                 590                   

gcc cac agc ctg atg gag ctg aac ccc tca gtc cca cct ggt ggc tcc       1824
Ala His Ser Leu Met Glu Leu Asn Pro Ser Val Pro Pro Gly Gly Ser           
        595                 600                 605                       

cca ctt ttg gat tct tcc cat tct ctt agc ccc agt tcc cca gac cca       1872
Pro Leu Leu Asp Ser Ser His Ser Leu Ser Pro Ser Ser Pro Asp Pro           
    610                 615                 620                           

gac aca cca tct cca gtt ggg gac aac cga gct ctg cag ggt agc cga       1920
Asp Thr Pro Ser Pro Val Gly Asp Asn Arg Ala Leu Gln Gly Ser Arg           
625                 630                 635                 640           

aac aca cga att ccc cac ttg gct ggc aag aag gca atg gct gag gag       1968
Asn Thr Arg Ile Pro His Leu Ala Gly Lys Lys Ala Met Ala Glu Glu           
                645                 650                 655               

gat aat ggt tcc att ggt gag gag aca gac tcc agt cca ggc agg aag       2016
Asp Asn Gly Ser Ile Gly Glu Glu Thr Asp Ser Ser Pro Gly Arg Lys           
            660                 665                 670                   

aag ttt cct ctc aaa att ttt aag aag cct ctt aag aag tag               2058
Lys Phe Pro Leu Lys Ile Phe Lys Lys Pro Leu Lys Lys                       
        675                 680                 685                       


<210>  74
<211>  685
<212>  PRT
<213>  Mus musculus

<400>  74

Met Asp Val Cys Ala Arg Leu Ala Leu Trp Leu Leu Trp Gly Leu Leu 
1               5                   10                  15      


Leu His Gln Gly Gln Ser Leu Ser His Ser His Ser Glu Lys Asn Thr 
            20                  25                  30          


Gly Ala Ser Ser Gly Ala Thr Ser Glu Glu Ser Thr Glu Ala Glu Phe 
        35                  40                  45              


Cys Arg Ile Asp Lys Pro Leu Cys His Ser Glu Asp Glu Lys Leu Ser 
    50                  55                  60                  


Phe Glu Ala Val Arg Asn Ile His Lys Leu Met Asp Asp Asp Ala Asn 
65                  70                  75                  80  


Gly Asp Val Asp Val Glu Glu Ser Asp Glu Phe Leu Arg Glu Asp Leu 
                85                  90                  95      


Asn Tyr His Asp Pro Thr Val Lys His Ser Thr Phe His Gly Glu Asp 
            100                 105                 110         


Lys Leu Ile Ser Val Glu Asp Leu Trp Lys Ala Trp Lys Ser Ser Glu 
        115                 120                 125             


Val Tyr Asn Trp Thr Val Asp Glu Val Ile Gln Trp Leu Ile Thr Tyr 
    130                 135                 140                 


Val Glu Leu Pro Gln Tyr Glu Glu Thr Phe Arg Lys Leu Gln Leu Thr 
145                 150                 155                 160 


Gly His Ala Met Pro Arg Leu Ala Val Thr Asn Thr Thr Met Thr Gly 
                165                 170                 175     


Thr Val Leu Lys Met Thr Asp Arg Ser His Arg Gln Lys Leu Gln Leu 
            180                 185                 190         


Lys Ala Leu Asp Thr Val Leu Phe Gly Pro Pro Leu Leu Thr Arg His 
        195                 200                 205             


Asn His Leu Lys Asp Phe Met Leu Val Val Ser Ile Val Ile Gly Val 
    210                 215                 220                 


Gly Gly Cys Trp Phe Ala Tyr Ile Gln Asn Arg Tyr Ser Lys Glu His 
225                 230                 235                 240 


Met Lys Lys Met Met Lys Asp Leu Glu Gly Leu His Arg Ala Glu Gln 
                245                 250                 255     


Ser Leu His Asp Leu Gln Glu Arg Leu His Lys Ala Gln Glu Glu His 
            260                 265                 270         


Arg Thr Val Glu Val Glu Lys Val His Leu Glu Lys Lys Leu Arg Asp 
        275                 280                 285             


Glu Ile Asn Leu Ala Lys Gln Glu Ala Gln Arg Leu Lys Glu Leu Arg 
    290                 295                 300                 


Glu Gly Thr Glu Asn Glu Arg Ser Arg Gln Lys Tyr Ala Glu Glu Glu 
305                 310                 315                 320 


Leu Glu Gln Val Arg Glu Ala Leu Arg Lys Ala Glu Lys Glu Leu Glu 
                325                 330                 335     


Ser His Ser Ser Trp Tyr Ala Pro Glu Ala Leu Gln Lys Trp Leu Gln 
            340                 345                 350         


Leu Thr His Glu Val Glu Val Gln Tyr Tyr Asn Ile Lys Lys Gln Asn 
        355                 360                 365             


Ala Glu Arg Gln Leu Leu Val Ala Lys Glu Gly Ala Glu Lys Ile Lys 
    370                 375                 380                 


Lys Lys Arg Asn Thr Leu Phe Gly Thr Phe His Val Ala His Ser Ser 
385                 390                 395                 400 


Ser Leu Asp Asp Val Asp His Lys Ile Leu Thr Ala Lys Gln Ala Leu 
                405                 410                 415     


Ser Glu Val Thr Ala Ala Leu Arg Glu Arg Leu His Arg Trp Gln Gln 
            420                 425                 430         


Ile Glu Ile Leu Cys Gly Phe Gln Ile Val Asn Asn Pro Gly Ile His 
        435                 440                 445             


Ser Leu Val Ala Ala Leu Asn Ile Asp Pro Ser Trp Met Gly Ser Thr 
    450                 455                 460                 


Arg Pro Asn Pro Ala His Phe Ile Met Thr Asp Asp Val Asp Asp Met 
465                 470                 475                 480 


Asp Glu Glu Ile Val Ser Pro Leu Ser Met Gln Ser Pro Ser Leu Gln 
                485                 490                 495     


Ser Ser Val Arg Gln Arg Leu Thr Glu Pro Gln Leu Gly Leu Gly Ser 
            500                 505                 510         


Gln Arg Asp Leu Thr His Ser Asp Ser Glu Ser Ser Leu His Met Ser 
        515                 520                 525             


Asp Arg Gln Arg Val Ala Pro Lys Pro Pro Gln Met Gly Arg Ala Ala 
    530                 535                 540                 


Asp Glu Ala Leu Asn Ala Met Pro Ser Asn Gly Ser His Arg Leu Ile 
545                 550                 555                 560 


Glu Gly Val His Pro Gly Ser Leu Val Glu Lys Leu Pro Asp Ser Pro 
                565                 570                 575     


Ala Leu Ala Lys Lys Thr Phe Met Ala Leu Asn His Gly Leu Asp Lys 
            580                 585                 590         


Ala His Ser Leu Met Glu Leu Asn Pro Ser Val Pro Pro Gly Gly Ser 
        595                 600                 605             


Pro Leu Leu Asp Ser Ser His Ser Leu Ser Pro Ser Ser Pro Asp Pro 
    610                 615                 620                 


Asp Thr Pro Ser Pro Val Gly Asp Asn Arg Ala Leu Gln Gly Ser Arg 
625                 630                 635                 640 


Asn Thr Arg Ile Pro His Leu Ala Gly Lys Lys Ala Met Ala Glu Glu 
                645                 650                 655     


Asp Asn Gly Ser Ile Gly Glu Glu Thr Asp Ser Ser Pro Gly Arg Lys 
            660                 665                 670         


Lys Phe Pro Leu Lys Ile Phe Lys Lys Pro Leu Lys Lys 
        675                 680                 685 


<210>  75
<211>  915
<212>  DNA
<213>  Rattus norvegicus


<220>
<221>  misc_feature
<223>  ORAI1-NCBI reference sequence NM_001 013982

<220>
<221>  CDS
<222>  (1)..(915)

<400>  75
atg cat ccg gag cct gcc ccg ccc ccg aac aac agc aat ccg gag ctt         48
Met His Pro Glu Pro Ala Pro Pro Pro Asn Asn Ser Asn Pro Glu Leu           
1               5                   10                  15                

ccc ttg agc ggc ggc agc agc act agc ggc agc cgc cgg agc cgc cgc         96
Pro Leu Ser Gly Gly Ser Ser Thr Ser Gly Ser Arg Arg Ser Arg Arg           
            20                  25                  30                    

cgc agc ggg gac ggg gag ccc acg ggg gcc cca ccg ctg ccg ccg ccg        144
Arg Ser Gly Asp Gly Glu Pro Thr Gly Ala Pro Pro Leu Pro Pro Pro           
        35                  40                  45                        

ccc gcc gtc agc tac ccg gac tgg atc ggc cag agt tac tcc gag gtg        192
Pro Ala Val Ser Tyr Pro Asp Trp Ile Gly Gln Ser Tyr Ser Glu Val           
    50                  55                  60                            

atg agc ctc aac gag cac tcg atg cag gcg ctg tcc tgg cgc aag ctc        240
Met Ser Leu Asn Glu His Ser Met Gln Ala Leu Ser Trp Arg Lys Leu           
65                  70                  75                  80            

tac ttg agc cgc gcc aag ctc aaa gcc tcc agc cga acc tcc gct ctg        288
Tyr Leu Ser Arg Ala Lys Leu Lys Ala Ser Ser Arg Thr Ser Ala Leu           
                85                  90                  95                

ctc tcc ggc ttc gcc atg gta gcg atg gtg gaa gtc cag ctg gac acg        336
Leu Ser Gly Phe Ala Met Val Ala Met Val Glu Val Gln Leu Asp Thr           
            100                 105                 110                   

gat cat gac tac ccg cca ggg tta ctc atc gtc ttc agc gcc tgc acc        384
Asp His Asp Tyr Pro Pro Gly Leu Leu Ile Val Phe Ser Ala Cys Thr           
        115                 120                 125                       

aca gtg ctg gtg gcc gtg cac ctg ttc gcc ctc atg atc agt acc tgc        432
Thr Val Leu Val Ala Val His Leu Phe Ala Leu Met Ile Ser Thr Cys           
    130                 135                 140                           

atc ctg ccc aac atc gag gct gtg agc aac gtc cac aac ctc aac tcc        480
Ile Leu Pro Asn Ile Glu Ala Val Ser Asn Val His Asn Leu Asn Ser           
145                 150                 155                 160           

gtc aag gag tcg ccg cac gag cgc atg cac cgc cac atc gag ctg gct        528
Val Lys Glu Ser Pro His Glu Arg Met His Arg His Ile Glu Leu Ala           
                165                 170                 175               

tgg gcc ttc tcc acc gtc atc ggg acg ctg ctt ttc ctg gcc gaa gtc        576
Trp Ala Phe Ser Thr Val Ile Gly Thr Leu Leu Phe Leu Ala Glu Val           
            180                 185                 190                   

gtg ctg ctc tgc tgg gtg aag ttc tta ccg ctc aag agg cag gcg gga        624
Val Leu Leu Cys Trp Val Lys Phe Leu Pro Leu Lys Arg Gln Ala Gly           
        195                 200                 205                       

cag cca agc ccc acc aag cca ccc acc gaa ccg gcc gtc gtc gtc gcc        672
Gln Pro Ser Pro Thr Lys Pro Pro Thr Glu Pro Ala Val Val Val Ala           
    210                 215                 220                           

aac agc agc aac aac ggt ggc atc acc ccg ggt gag gcg gct gcc atc        720
Asn Ser Ser Asn Asn Gly Gly Ile Thr Pro Gly Glu Ala Ala Ala Ile           
225                 230                 235                 240           

gcc tcc act gcc atc atg gtc ccc tgt ggc ctg gtg ttt atc gtc ttt        768
Ala Ser Thr Ala Ile Met Val Pro Cys Gly Leu Val Phe Ile Val Phe           
                245                 250                 255               

gcc gtt cac ttc tac cgc tca ctg gtc agc cat aag acg gac cga cag        816
Ala Val His Phe Tyr Arg Ser Leu Val Ser His Lys Thr Asp Arg Gln           
            260                 265                 270                   

ttc cag gag ctc aac gag ctg gcc gag ttt gcc cgc ttg cag gac cag        864
Phe Gln Glu Leu Asn Glu Leu Ala Glu Phe Ala Arg Leu Gln Asp Gln           
        275                 280                 285                       

ctg gac cac aga ggg gac cat tct cta aca ccg ggc acc cac tat gcc        912
Leu Asp His Arg Gly Asp His Ser Leu Thr Pro Gly Thr His Tyr Ala           
    290                 295                 300                           

taa                                                                    915


<210>  76
<211>  304
<212>  PRT
<213>  Rattus norvegicus

<400>  76

Met His Pro Glu Pro Ala Pro Pro Pro Asn Asn Ser Asn Pro Glu Leu 
1               5                   10                  15      


Pro Leu Ser Gly Gly Ser Ser Thr Ser Gly Ser Arg Arg Ser Arg Arg 
            20                  25                  30          


Arg Ser Gly Asp Gly Glu Pro Thr Gly Ala Pro Pro Leu Pro Pro Pro 
        35                  40                  45              


Pro Ala Val Ser Tyr Pro Asp Trp Ile Gly Gln Ser Tyr Ser Glu Val 
    50                  55                  60                  


Met Ser Leu Asn Glu His Ser Met Gln Ala Leu Ser Trp Arg Lys Leu 
65                  70                  75                  80  


Tyr Leu Ser Arg Ala Lys Leu Lys Ala Ser Ser Arg Thr Ser Ala Leu 
                85                  90                  95      


Leu Ser Gly Phe Ala Met Val Ala Met Val Glu Val Gln Leu Asp Thr 
            100                 105                 110         


Asp His Asp Tyr Pro Pro Gly Leu Leu Ile Val Phe Ser Ala Cys Thr 
        115                 120                 125             


Thr Val Leu Val Ala Val His Leu Phe Ala Leu Met Ile Ser Thr Cys 
    130                 135                 140                 


Ile Leu Pro Asn Ile Glu Ala Val Ser Asn Val His Asn Leu Asn Ser 
145                 150                 155                 160 


Val Lys Glu Ser Pro His Glu Arg Met His Arg His Ile Glu Leu Ala 
                165                 170                 175     


Trp Ala Phe Ser Thr Val Ile Gly Thr Leu Leu Phe Leu Ala Glu Val 
            180                 185                 190         


Val Leu Leu Cys Trp Val Lys Phe Leu Pro Leu Lys Arg Gln Ala Gly 
        195                 200                 205             


Gln Pro Ser Pro Thr Lys Pro Pro Thr Glu Pro Ala Val Val Val Ala 
    210                 215                 220                 


Asn Ser Ser Asn Asn Gly Gly Ile Thr Pro Gly Glu Ala Ala Ala Ile 
225                 230                 235                 240 


Ala Ser Thr Ala Ile Met Val Pro Cys Gly Leu Val Phe Ile Val Phe 
                245                 250                 255     


Ala Val His Phe Tyr Arg Ser Leu Val Ser His Lys Thr Asp Arg Gln 
            260                 265                 270         


Phe Gln Glu Leu Asn Glu Leu Ala Glu Phe Ala Arg Leu Gln Asp Gln 
        275                 280                 285             


Leu Asp His Arg Gly Asp His Ser Leu Thr Pro Gly Thr His Tyr Ala 
    290                 295                 300                 


<210>  77
<211>  2058
<212>  DNA
<213>  Rattus norvegicus


<220>
<221>  misc_feature
<223>  STIM1-NCBI reference sequence XM_341 896

<220>
<221>  CDS
<222>  (1)..(2058)

<400>  77
atg gat gtg tgc gct cgt ctt gcc ctg tgg ctt ctt tgg ggg ctc ctt         48
Met Asp Val Cys Ala Arg Leu Ala Leu Trp Leu Leu Trp Gly Leu Leu           
1               5                   10                  15                

ctg cat cag ggc cag agt ctc agc cat agt cac agt gag aag aat aca         96
Leu His Gln Gly Gln Ser Leu Ser His Ser His Ser Glu Lys Asn Thr           
            20                  25                  30                    

gga gct agc tcg ggg gcg act tct gaa gag tct acc gaa gca gag ttt        144
Gly Ala Ser Ser Gly Ala Thr Ser Glu Glu Ser Thr Glu Ala Glu Phe           
        35                  40                  45                        

tgc cgg att gac aag ccc ctg tgc cac agt gaa gat gag aag ctc agc        192
Cys Arg Ile Asp Lys Pro Leu Cys His Ser Glu Asp Glu Lys Leu Ser           
    50                  55                  60                            

ttt gag gcc gtc cgc aac atc cac aag ctg atg gat gat gat gcc aat        240
Phe Glu Ala Val Arg Asn Ile His Lys Leu Met Asp Asp Asp Ala Asn           
65                  70                  75                  80            

ggt gat gtg gat gtg gaa gaa agt gat gag ttc cta agg gaa gac ctc        288
Gly Asp Val Asp Val Glu Glu Ser Asp Glu Phe Leu Arg Glu Asp Leu           
                85                  90                  95                

aat tac cat gac cct aca gtg aaa cac agc acc ttc cat ggt gag gac        336
Asn Tyr His Asp Pro Thr Val Lys His Ser Thr Phe His Gly Glu Asp           
            100                 105                 110                   

aag ctt atc agc gtg gag gac cta tgg aag gca tgg aag gca tca gaa        384
Lys Leu Ile Ser Val Glu Asp Leu Trp Lys Ala Trp Lys Ala Ser Glu           
        115                 120                 125                       

gtg tat aac tgg acc gtg gat gag gtg ata cag tgg ctg att acg tat        432
Val Tyr Asn Trp Thr Val Asp Glu Val Ile Gln Trp Leu Ile Thr Tyr           
    130                 135                 140                           

gtg gag ctg cca cag tat gag gag act ttc cgg aag ttg cag ctt act        480
Val Glu Leu Pro Gln Tyr Glu Glu Thr Phe Arg Lys Leu Gln Leu Thr           
145                 150                 155                 160           

ggc cat gcc atg cca agg cta gct gta aca aac acc acc atg aca ggg        528
Gly His Ala Met Pro Arg Leu Ala Val Thr Asn Thr Thr Met Thr Gly           
                165                 170                 175               

act gtc ctg aag atg aca gac cgg agc cac agg cag aag ctg cag ctg        576
Thr Val Leu Lys Met Thr Asp Arg Ser His Arg Gln Lys Leu Gln Leu           
            180                 185                 190                   

aag gct ctg gac aca gtg ctg ttc ggg cct cct ctc ttg act cgc cac        624
Lys Ala Leu Asp Thr Val Leu Phe Gly Pro Pro Leu Leu Thr Arg His           
        195                 200                 205                       

aat cac ctg aag gac ttc atg ctg gtg gta tct atc gtg att ggt gtg        672
Asn His Leu Lys Asp Phe Met Leu Val Val Ser Ile Val Ile Gly Val           
    210                 215                 220                           

ggt ggc tgc tgg ttt gcc tat atc cag aac cgt tac tct aag gag cac        720
Gly Gly Cys Trp Phe Ala Tyr Ile Gln Asn Arg Tyr Ser Lys Glu His           
225                 230                 235                 240           

atg aag aaa atg atg aag gat ctg gaa gga ttg cac cga gct gag cag        768
Met Lys Lys Met Met Lys Asp Leu Glu Gly Leu His Arg Ala Glu Gln           
                245                 250                 255               

agt ctg cat gac ctt cag gaa agg ctg cac aag gcc cag gag gag cac        816
Ser Leu His Asp Leu Gln Glu Arg Leu His Lys Ala Gln Glu Glu His           
            260                 265                 270                   

cga aca gtg gaa gta gag aag gtc cac ctg gag aag aag ctg cgt gac        864
Arg Thr Val Glu Val Glu Lys Val His Leu Glu Lys Lys Leu Arg Asp           
        275                 280                 285                       

gag atc aat ctt gcc aag cag gaa gct cag cgg ctg aag gag ctg agg        912
Glu Ile Asn Leu Ala Lys Gln Glu Ala Gln Arg Leu Lys Glu Leu Arg           
    290                 295                 300                           

gag ggt acc gag aat gag agg agc cgc caa aaa tat gct gag gaa gag        960
Glu Gly Thr Glu Asn Glu Arg Ser Arg Gln Lys Tyr Ala Glu Glu Glu           
305                 310                 315                 320           

ctg gag cag gtt cgg gag gct ttg agg aaa gca gag aag gag ctg gaa       1008
Leu Glu Gln Val Arg Glu Ala Leu Arg Lys Ala Glu Lys Glu Leu Glu           
                325                 330                 335               

tca cac agc tcc tgg tat gct cct gag gcc ctg cag aag tgg ctg cag       1056
Ser His Ser Ser Trp Tyr Ala Pro Glu Ala Leu Gln Lys Trp Leu Gln           
            340                 345                 350                   

ctg aca cat gag gtg gag gtg cag tac tac aac atc aag aag caa aat       1104
Leu Thr His Glu Val Glu Val Gln Tyr Tyr Asn Ile Lys Lys Gln Asn           
        355                 360                 365                       

gca gag agg cag ctg ctg gtg gcc aag gag ggg gct gag aaa ata aaa       1152
Ala Glu Arg Gln Leu Leu Val Ala Lys Glu Gly Ala Glu Lys Ile Lys           
    370                 375                 380                           

aag aag aga aac acg ctt ttt ggt acc ttc cat gtg gcc cac agc tcg       1200
Lys Lys Arg Asn Thr Leu Phe Gly Thr Phe His Val Ala His Ser Ser           
385                 390                 395                 400           

tcc ctg gat gac gtg gat cat aaa atc tta act gct aag cag gca ctg       1248
Ser Leu Asp Asp Val Asp His Lys Ile Leu Thr Ala Lys Gln Ala Leu           
                405                 410                 415               

agt gag gtg aca gca gcc ctg agg gag cgc ctg cac cgg tgg cag cag       1296
Ser Glu Val Thr Ala Ala Leu Arg Glu Arg Leu His Arg Trp Gln Gln           
            420                 425                 430                   

atc gag atc ctc tgt ggt ttc cag att gtc aat aac cct ggc atc cac       1344
Ile Glu Ile Leu Cys Gly Phe Gln Ile Val Asn Asn Pro Gly Ile His           
        435                 440                 445                       

tcc ttg gtg gcc gcg ctc aac ata gat ccc agc tgg atg ggc agt acc       1392
Ser Leu Val Ala Ala Leu Asn Ile Asp Pro Ser Trp Met Gly Ser Thr           
    450                 455                 460                           

cgc cct aac cct gcc cac ttc atc atg act gac gat gtg gat gac atg       1440
Arg Pro Asn Pro Ala His Phe Ile Met Thr Asp Asp Val Asp Asp Met           
465                 470                 475                 480           

gat gag gag atc gtg tcg ccc ttg tcc atg cag tcc ccc agc ctg cag       1488
Asp Glu Glu Ile Val Ser Pro Leu Ser Met Gln Ser Pro Ser Leu Gln           
                485                 490                 495               

agc agt gtc cgg cag cgc ctg acg gag cca cag cat ggc ctg gga tct       1536
Ser Ser Val Arg Gln Arg Leu Thr Glu Pro Gln His Gly Leu Gly Ser           
            500                 505                 510                   

cag agg gat ttg acc cat tcc gat tcg gag tcc tcc ctc cac acg agt       1584
Gln Arg Asp Leu Thr His Ser Asp Ser Glu Ser Ser Leu His Thr Ser           
        515                 520                 525                       

gac cgc cag cgt gtg gcc ccc aag cct cct cag atg ggc cgt gct gca       1632
Asp Arg Gln Arg Val Ala Pro Lys Pro Pro Gln Met Gly Arg Ala Ala           
    530                 535                 540                           

gat gag gct ctc aat gcc acg tct tcc aat ggt agc cat cgg ctg att       1680
Asp Glu Ala Leu Asn Ala Thr Ser Ser Asn Gly Ser His Arg Leu Ile           
545                 550                 555                 560           

gag ggg gtc cat cca gga tct ctg gtg gag aaa ctg cct gac agc cct       1728
Glu Gly Val His Pro Gly Ser Leu Val Glu Lys Leu Pro Asp Ser Pro           
                565                 570                 575               

gct ctg gcc aag aag aca atc ctg gcg ctg aac cat ggc cta gat aag       1776
Ala Leu Ala Lys Lys Thr Ile Leu Ala Leu Asn His Gly Leu Asp Lys           
            580                 585                 590                   

gcc cac agc ctg atg gag ctg aac ccc tca gtc cca cct ggt ggc tcc       1824
Ala His Ser Leu Met Glu Leu Asn Pro Ser Val Pro Pro Gly Gly Ser           
        595                 600                 605                       

cca ctt ttg gat tct tcc cat tct cat agc ccc agc tcc cca gac cca       1872
Pro Leu Leu Asp Ser Ser His Ser His Ser Pro Ser Ser Pro Asp Pro           
    610                 615                 620                           

gac aca cca tct cca gtt ggg gac agc cga gcc ctg cag ggt agc cga       1920
Asp Thr Pro Ser Pro Val Gly Asp Ser Arg Ala Leu Gln Gly Ser Arg           
625                 630                 635                 640           

aac aca cga att ccc cac ttg gct ggc aag aag gct atg gct gag gag       1968
Asn Thr Arg Ile Pro His Leu Ala Gly Lys Lys Ala Met Ala Glu Glu           
                645                 650                 655               

gat aat ggc tct att ggt gag gag aca gac tct agt cca ggc agg aag       2016
Asp Asn Gly Ser Ile Gly Glu Glu Thr Asp Ser Ser Pro Gly Arg Lys           
            660                 665                 670                   

aag ttt ccc ctc aaa att ttt aag aag cct ctt aag aag tag               2058
Lys Phe Pro Leu Lys Ile Phe Lys Lys Pro Leu Lys Lys                       
        675                 680                 685                       


<210>  78
<211>  685
<212>  PRT
<213>  Rattus norvegicus

<400>  78

Met Asp Val Cys Ala Arg Leu Ala Leu Trp Leu Leu Trp Gly Leu Leu 
1               5                   10                  15      


Leu His Gln Gly Gln Ser Leu Ser His Ser His Ser Glu Lys Asn Thr 
            20                  25                  30          


Gly Ala Ser Ser Gly Ala Thr Ser Glu Glu Ser Thr Glu Ala Glu Phe 
        35                  40                  45              


Cys Arg Ile Asp Lys Pro Leu Cys His Ser Glu Asp Glu Lys Leu Ser 
    50                  55                  60                  


Phe Glu Ala Val Arg Asn Ile His Lys Leu Met Asp Asp Asp Ala Asn 
65                  70                  75                  80  


Gly Asp Val Asp Val Glu Glu Ser Asp Glu Phe Leu Arg Glu Asp Leu 
                85                  90                  95      


Asn Tyr His Asp Pro Thr Val Lys His Ser Thr Phe His Gly Glu Asp 
            100                 105                 110         


Lys Leu Ile Ser Val Glu Asp Leu Trp Lys Ala Trp Lys Ala Ser Glu 
        115                 120                 125             


Val Tyr Asn Trp Thr Val Asp Glu Val Ile Gln Trp Leu Ile Thr Tyr 
    130                 135                 140                 


Val Glu Leu Pro Gln Tyr Glu Glu Thr Phe Arg Lys Leu Gln Leu Thr 
145                 150                 155                 160 


Gly His Ala Met Pro Arg Leu Ala Val Thr Asn Thr Thr Met Thr Gly 
                165                 170                 175     


Thr Val Leu Lys Met Thr Asp Arg Ser His Arg Gln Lys Leu Gln Leu 
            180                 185                 190         


Lys Ala Leu Asp Thr Val Leu Phe Gly Pro Pro Leu Leu Thr Arg His 
        195                 200                 205             


Asn His Leu Lys Asp Phe Met Leu Val Val Ser Ile Val Ile Gly Val 
    210                 215                 220                 


Gly Gly Cys Trp Phe Ala Tyr Ile Gln Asn Arg Tyr Ser Lys Glu His 
225                 230                 235                 240 


Met Lys Lys Met Met Lys Asp Leu Glu Gly Leu His Arg Ala Glu Gln 
                245                 250                 255     


Ser Leu His Asp Leu Gln Glu Arg Leu His Lys Ala Gln Glu Glu His 
            260                 265                 270         


Arg Thr Val Glu Val Glu Lys Val His Leu Glu Lys Lys Leu Arg Asp 
        275                 280                 285             


Glu Ile Asn Leu Ala Lys Gln Glu Ala Gln Arg Leu Lys Glu Leu Arg 
    290                 295                 300                 


Glu Gly Thr Glu Asn Glu Arg Ser Arg Gln Lys Tyr Ala Glu Glu Glu 
305                 310                 315                 320 


Leu Glu Gln Val Arg Glu Ala Leu Arg Lys Ala Glu Lys Glu Leu Glu 
                325                 330                 335     


Ser His Ser Ser Trp Tyr Ala Pro Glu Ala Leu Gln Lys Trp Leu Gln 
            340                 345                 350         


Leu Thr His Glu Val Glu Val Gln Tyr Tyr Asn Ile Lys Lys Gln Asn 
        355                 360                 365             


Ala Glu Arg Gln Leu Leu Val Ala Lys Glu Gly Ala Glu Lys Ile Lys 
    370                 375                 380                 


Lys Lys Arg Asn Thr Leu Phe Gly Thr Phe His Val Ala His Ser Ser 
385                 390                 395                 400 


Ser Leu Asp Asp Val Asp His Lys Ile Leu Thr Ala Lys Gln Ala Leu 
                405                 410                 415     


Ser Glu Val Thr Ala Ala Leu Arg Glu Arg Leu His Arg Trp Gln Gln 
            420                 425                 430         


Ile Glu Ile Leu Cys Gly Phe Gln Ile Val Asn Asn Pro Gly Ile His 
        435                 440                 445             


Ser Leu Val Ala Ala Leu Asn Ile Asp Pro Ser Trp Met Gly Ser Thr 
    450                 455                 460                 


Arg Pro Asn Pro Ala His Phe Ile Met Thr Asp Asp Val Asp Asp Met 
465                 470                 475                 480 


Asp Glu Glu Ile Val Ser Pro Leu Ser Met Gln Ser Pro Ser Leu Gln 
                485                 490                 495     


Ser Ser Val Arg Gln Arg Leu Thr Glu Pro Gln His Gly Leu Gly Ser 
            500                 505                 510         


Gln Arg Asp Leu Thr His Ser Asp Ser Glu Ser Ser Leu His Thr Ser 
        515                 520                 525             


Asp Arg Gln Arg Val Ala Pro Lys Pro Pro Gln Met Gly Arg Ala Ala 
    530                 535                 540                 


Asp Glu Ala Leu Asn Ala Thr Ser Ser Asn Gly Ser His Arg Leu Ile 
545                 550                 555                 560 


Glu Gly Val His Pro Gly Ser Leu Val Glu Lys Leu Pro Asp Ser Pro 
                565                 570                 575     


Ala Leu Ala Lys Lys Thr Ile Leu Ala Leu Asn His Gly Leu Asp Lys 
            580                 585                 590         


Ala His Ser Leu Met Glu Leu Asn Pro Ser Val Pro Pro Gly Gly Ser 
        595                 600                 605             


Pro Leu Leu Asp Ser Ser His Ser His Ser Pro Ser Ser Pro Asp Pro 
    610                 615                 620                 


Asp Thr Pro Ser Pro Val Gly Asp Ser Arg Ala Leu Gln Gly Ser Arg 
625                 630                 635                 640 


Asn Thr Arg Ile Pro His Leu Ala Gly Lys Lys Ala Met Ala Glu Glu 
                645                 650                 655     


Asp Asn Gly Ser Ile Gly Glu Glu Thr Asp Ser Ser Pro Gly Arg Lys 
            660                 665                 670         


Lys Phe Pro Leu Lys Ile Phe Lys Lys Pro Leu Lys Lys 
        675                 680                 685 


<210>  79
<211>  2057
<212>  DNA
<213>  Pan troglodytes


<220>
<221>  misc_feature
<223>  ORAI1 coding sequence-NCBI Accession XM_528 664

<220>
<221>  CDS
<222>  (118)..(1020)

<400>  79
ctcgtcctgt gcggccggcc gggtgaggcc gggcccgcgt agggggcagt cggcggctgc       60

ctccggcgga ggtgcctcgc ggcgcccggg ccggcccgcg cctcggcggc gtgctcc         117

atg cat ccg gag ccc gcc ccg ccc ccg agc ggc agc agc ccc gag ctt        165
Met His Pro Glu Pro Ala Pro Pro Pro Ser Gly Ser Ser Pro Glu Leu           
1               5                   10                  15                

ccc cca agc ggc ggt agc acc acc agc ggc agc cgc cgg agc cgc cgc        213
Pro Pro Ser Gly Gly Ser Thr Thr Ser Gly Ser Arg Arg Ser Arg Arg           
            20                  25                  30                    

cgc agc ggg gac ggg gag ccc ccg ggg gcc ccg cca cct ccg ccg tcc        261
Arg Ser Gly Asp Gly Glu Pro Pro Gly Ala Pro Pro Pro Pro Pro Ser           
        35                  40                  45                        

gcc gtc acc tac ccg gac tgg atc ggc cag agt tac tcc gag gtg atg        309
Ala Val Thr Tyr Pro Asp Trp Ile Gly Gln Ser Tyr Ser Glu Val Met           
    50                  55                  60                            

agc ctc aac gag cac tcc atg cag gcg ctg tcc tgg cgc aag ctc tac        357
Ser Leu Asn Glu His Ser Met Gln Ala Leu Ser Trp Arg Lys Leu Tyr           
65                  70                  75                  80            

ttg agc cgc gcc aag ctt aaa gcc tcc agc cgg acc tcg gct ctg ctc        405
Leu Ser Arg Ala Lys Leu Lys Ala Ser Ser Arg Thr Ser Ala Leu Leu           
                85                  90                  95                

tcc ggc ttc gcc atg gtg gca atg gtg gag gtg cag ctg gac gct gac        453
Ser Gly Phe Ala Met Val Ala Met Val Glu Val Gln Leu Asp Ala Asp           
            100                 105                 110                   

cac gac tac cca ccg ggg ctg ctc atc gcc ttc agt gcc tgc acc aca        501
His Asp Tyr Pro Pro Gly Leu Leu Ile Ala Phe Ser Ala Cys Thr Thr           
        115                 120                 125                       

gtg ctg gtg gct gtg cac ctg ttt gcg ctc atg atc agc acc tgc atc        549
Val Leu Val Ala Val His Leu Phe Ala Leu Met Ile Ser Thr Cys Ile           
    130                 135                 140                           

ctg ccc aac atc gag gca gtg agc aac gtg cac aat ctc aac tcg gtc        597
Leu Pro Asn Ile Glu Ala Val Ser Asn Val His Asn Leu Asn Ser Val           
145                 150                 155                 160           

aag gag tcc ccc cac gag cgc atg cac cgc cac atc gag ctg gcc tgg        645
Lys Glu Ser Pro His Glu Arg Met His Arg His Ile Glu Leu Ala Trp           
                165                 170                 175               

gcc ttc tcc act gtc atc ggc acg ctg ctc ttc ctg gct gag gtg gtg        693
Ala Phe Ser Thr Val Ile Gly Thr Leu Leu Phe Leu Ala Glu Val Val           
            180                 185                 190                   

ctg ctc tgc tgg gtc aag ttc tta ccc ctc aag aag cag cca ggc cag        741
Leu Leu Cys Trp Val Lys Phe Leu Pro Leu Lys Lys Gln Pro Gly Gln           
        195                 200                 205                       

cca agg ccc acc agc aag ccc ccc gcc ggt ggt gca gca gcc aac gtc        789
Pro Arg Pro Thr Ser Lys Pro Pro Ala Gly Gly Ala Ala Ala Asn Val           
    210                 215                 220                           

agc acc agc ggc atc acc ccg ggc cag gca gct gcc atc gcc tcg acc        837
Ser Thr Ser Gly Ile Thr Pro Gly Gln Ala Ala Ala Ile Ala Ser Thr           
225                 230                 235                 240           

acc atc atg gtg ccc ttc ggc ctg atc ttt atc gtc ttt gcc gtc cac        885
Thr Ile Met Val Pro Phe Gly Leu Ile Phe Ile Val Phe Ala Val His           
                245                 250                 255               

ttc tac cgc tca ctg gtc agc cat aag acc gac cga cag ttc cag gag        933
Phe Tyr Arg Ser Leu Val Ser His Lys Thr Asp Arg Gln Phe Gln Glu           
            260                 265                 270                   

ctc aac gag ctg gca gag ttt gcc cgc tta cag gac cag ctg gac cac        981
Leu Asn Glu Leu Ala Glu Phe Ala Arg Leu Gln Asp Gln Leu Asp His           
        275                 280                 285                       

aga ggg gac cac ccc ctg acg ccc ggc agc cac tat gcc taggcccatg        1030
Arg Gly Asp His Pro Leu Thr Pro Gly Ser His Tyr Ala                       
    290                 295                 300                           

tggtctgggc ccttccagtg ctttggcctt acgcccttcc ccatgacctt gtcctgccgc     1090

agcctcacgg acagcctgtg cagggggctg ggcttcagca aggggcagag cgtggaggga     1150

agaggctttt tataagagaa atttctgcac tttgaaactg tcctctaaga gaataagcat     1210

ttcctgttct tccagctcca ggtccacctc ctgttgggag gcagtggggg gtcaaagtgg     1270

ggccacacac tcgctgtgtc ccctctcctc ccctgtgcca gtgccacctg ggtgccttct     1330

cttgtcctgt ccgtctcaac ctccctcccg tccagcattg agtgtgtaca tgtgtgtgtg     1390

acacataaat atactcataa ggacacctcc ttcccgtgtc ttgtatttgt tgggcctggg     1450

ctactgctca ccctggttag gtgagcctct aggaaaactt aaaacaaatt ttaagccagg     1510

tatggtggca catacctgtg gtctcagcta ttcaggaggc caaggcagga ggatctcttg     1570

agcccaggag tttgagaccc catctcaaac aaaaaataca aaaattagcc agccacggcg     1630

cctgcacttc cagctccttt gagagactga ggcaggaaga ttgcctaagc ccaggaggcc     1690

aagtctgcag tgagctatag taacaccact gcactccaac ctgggcaaca gagggagact     1750

ctgtctctaa aaaaatagaa aaatttgccc cgcatggtgg ctcacgcctg taatcctagc     1810

cctttggaag gctaaggcgg gcagatcact tgaggtcggg agttcgagac cagcctgacc     1870

aacatggaga aaccccgtct gtactaaaaa tacaaaatta gctgggtttg gtggcgcatg     1930

cttgtaatcc cagctactcg ggaggctgag gcaggagaat cgcttgaacc caggaggcgg     1990

aggttgcagt gagctgagat cgcgccattg cactccagcc tgggcaacaa cagtgaaact     2050

ccatctc                                                               2057


<210>  80
<211>  301
<212>  PRT
<213>  Pan troglodytes

<400>  80

Met His Pro Glu Pro Ala Pro Pro Pro Ser Gly Ser Ser Pro Glu Leu 
1               5                   10                  15      


Pro Pro Ser Gly Gly Ser Thr Thr Ser Gly Ser Arg Arg Ser Arg Arg 
            20                  25                  30          


Arg Ser Gly Asp Gly Glu Pro Pro Gly Ala Pro Pro Pro Pro Pro Ser 
        35                  40                  45              


Ala Val Thr Tyr Pro Asp Trp Ile Gly Gln Ser Tyr Ser Glu Val Met 
    50                  55                  60                  


Ser Leu Asn Glu His Ser Met Gln Ala Leu Ser Trp Arg Lys Leu Tyr 
65                  70                  75                  80  


Leu Ser Arg Ala Lys Leu Lys Ala Ser Ser Arg Thr Ser Ala Leu Leu 
                85                  90                  95      


Ser Gly Phe Ala Met Val Ala Met Val Glu Val Gln Leu Asp Ala Asp 
            100                 105                 110         


His Asp Tyr Pro Pro Gly Leu Leu Ile Ala Phe Ser Ala Cys Thr Thr 
        115                 120                 125             


Val Leu Val Ala Val His Leu Phe Ala Leu Met Ile Ser Thr Cys Ile 
    130                 135                 140                 


Leu Pro Asn Ile Glu Ala Val Ser Asn Val His Asn Leu Asn Ser Val 
145                 150                 155                 160 


Lys Glu Ser Pro His Glu Arg Met His Arg His Ile Glu Leu Ala Trp 
                165                 170                 175     


Ala Phe Ser Thr Val Ile Gly Thr Leu Leu Phe Leu Ala Glu Val Val 
            180                 185                 190         


Leu Leu Cys Trp Val Lys Phe Leu Pro Leu Lys Lys Gln Pro Gly Gln 
        195                 200                 205             


Pro Arg Pro Thr Ser Lys Pro Pro Ala Gly Gly Ala Ala Ala Asn Val 
    210                 215                 220                 


Ser Thr Ser Gly Ile Thr Pro Gly Gln Ala Ala Ala Ile Ala Ser Thr 
225                 230                 235                 240 


Thr Ile Met Val Pro Phe Gly Leu Ile Phe Ile Val Phe Ala Val His 
                245                 250                 255     


Phe Tyr Arg Ser Leu Val Ser His Lys Thr Asp Arg Gln Phe Gln Glu 
            260                 265                 270         


Leu Asn Glu Leu Ala Glu Phe Ala Arg Leu Gln Asp Gln Leu Asp His 
        275                 280                 285             


Arg Gly Asp His Pro Leu Thr Pro Gly Ser His Tyr Ala 
    290                 295                 300     


<210>  81
<211>  771
<212>  DNA
<213>  Macaca fascicularis


<220>
<221>  misc_feature
<223>  ORAI1 coding sequence (partial)

<220>
<221>  CDS
<222>  (47)..(763)

<400>  81
cgccgtcacc tacccggact ggatcggcca gagttactcc gaggtg atg agt ctc          55
                                                   Met Ser Leu            
                                                   1                      

aac gag cac tcc atg cag gcg ctg tcc tgg cgc aag ctc tat ttg agc        103
Asn Glu His Ser Met Gln Ala Leu Ser Trp Arg Lys Leu Tyr Leu Ser           
    5                   10                  15                            

cgc gcc aag ctc aaa gcc tcc agc cgg acc tcg gct ctg ctc tcc ggc        151
Arg Ala Lys Leu Lys Ala Ser Ser Arg Thr Ser Ala Leu Leu Ser Gly           
20                  25                  30                  35            

ttc gcc atg gtg gca atg gtg gag gtg cag ctg gac gct gac cac gac        199
Phe Ala Met Val Ala Met Val Glu Val Gln Leu Asp Ala Asp His Asp           
                40                  45                  50                

tac ccg cca ggg ctg ctc atc gcc ttc agt gcc tgc acc acg gtg ctg        247
Tyr Pro Pro Gly Leu Leu Ile Ala Phe Ser Ala Cys Thr Thr Val Leu           
            55                  60                  65                    

gtg gct gtg cac ctg ttt gca ctc atg atc agc acc tgc atc ctg ccc        295
Val Ala Val His Leu Phe Ala Leu Met Ile Ser Thr Cys Ile Leu Pro           
        70                  75                  80                        

aac atc gag gcg gtg agc aac gtg cac aac ctc aac tcg gtc aag gag        343
Asn Ile Glu Ala Val Ser Asn Val His Asn Leu Asn Ser Val Lys Glu           
    85                  90                  95                            

tcc ccc cac gag cgc atg cac cgc cac atc gag ctg gcc tgg gcc ttc        391
Ser Pro His Glu Arg Met His Arg His Ile Glu Leu Ala Trp Ala Phe           
100                 105                 110                 115           

tcc acc gtc atc ggc acg ctg ctt ttc ctg gcc gag gtc gtg ctg ctc        439
Ser Thr Val Ile Gly Thr Leu Leu Phe Leu Ala Glu Val Val Leu Leu           
                120                 125                 130               

tgc tgg gtc aag ttc ttg ccc ctc aag aag cag cca ggc cag ccg agg        487
Cys Trp Val Lys Phe Leu Pro Leu Lys Lys Gln Pro Gly Gln Pro Arg           
            135                 140                 145                   

ccc acc agc aag ccc ccc gcc agt ggt gca gcc gcc aac gtc agc acc        535
Pro Thr Ser Lys Pro Pro Ala Ser Gly Ala Ala Ala Asn Val Ser Thr           
        150                 155                 160                       

agc ggc atc acc ccg ggc cag gca gcc gcc atc gcc tcg acc acc atc        583
Ser Gly Ile Thr Pro Gly Gln Ala Ala Ala Ile Ala Ser Thr Thr Ile           
    165                 170                 175                           

atg gtg ccc ttc ggc ctg atc ttt att gtc ttc gcc gtc cac ttc tac        631
Met Val Pro Phe Gly Leu Ile Phe Ile Val Phe Ala Val His Phe Tyr           
180                 185                 190                 195           

cgc tca ctg gtc agc cat aag acg gac cga cag ttc cag gag ctc aac        679
Arg Ser Leu Val Ser His Lys Thr Asp Arg Gln Phe Gln Glu Leu Asn           
                200                 205                 210               

gag ctg gcg gag ttt gct cgc tta cag gac cag ctg gac cac aga ggg        727
Glu Leu Ala Glu Phe Ala Arg Leu Gln Asp Gln Leu Asp His Arg Gly           
            215                 220                 225                   

gac cac ccc ctg acg ccc ggc agc cac tat gcc tag gcggccgc               771
Asp His Pro Leu Thr Pro Gly Ser His Tyr Ala                               
        230                 235                                           


<210>  82
<211>  238
<212>  PRT
<213>  Macaca fascicularis

<400>  82

Met Ser Leu Asn Glu His Ser Met Gln Ala Leu Ser Trp Arg Lys Leu 
1               5                   10                  15      


Tyr Leu Ser Arg Ala Lys Leu Lys Ala Ser Ser Arg Thr Ser Ala Leu 
            20                  25                  30          


Leu Ser Gly Phe Ala Met Val Ala Met Val Glu Val Gln Leu Asp Ala 
        35                  40                  45              


Asp His Asp Tyr Pro Pro Gly Leu Leu Ile Ala Phe Ser Ala Cys Thr 
    50                  55                  60                  


Thr Val Leu Val Ala Val His Leu Phe Ala Leu Met Ile Ser Thr Cys 
65                  70                  75                  80  


Ile Leu Pro Asn Ile Glu Ala Val Ser Asn Val His Asn Leu Asn Ser 
                85                  90                  95      


Val Lys Glu Ser Pro His Glu Arg Met His Arg His Ile Glu Leu Ala 
            100                 105                 110         


Trp Ala Phe Ser Thr Val Ile Gly Thr Leu Leu Phe Leu Ala Glu Val 
        115                 120                 125             


Val Leu Leu Cys Trp Val Lys Phe Leu Pro Leu Lys Lys Gln Pro Gly 
    130                 135                 140                 


Gln Pro Arg Pro Thr Ser Lys Pro Pro Ala Ser Gly Ala Ala Ala Asn 
145                 150                 155                 160 


Val Ser Thr Ser Gly Ile Thr Pro Gly Gln Ala Ala Ala Ile Ala Ser 
                165                 170                 175     


Thr Thr Ile Met Val Pro Phe Gly Leu Ile Phe Ile Val Phe Ala Val 
            180                 185                 190         


His Phe Tyr Arg Ser Leu Val Ser His Lys Thr Asp Arg Gln Phe Gln 
        195                 200                 205             


Glu Leu Asn Glu Leu Ala Glu Phe Ala Arg Leu Gln Asp Gln Leu Asp 
    210                 215                 220                 


His Arg Gly Asp His Pro Leu Thr Pro Gly Ser His Tyr Ala 
225                 230                 235             


<210>  83
<211>  1086
<212>  DNA
<213>  Canis familiaris


<220>
<221>  misc_feature
<223>  ORAI1 coding sequence-NCBI Accession XM_543 386

<220>
<221>  CDS
<222>  (1)..(1086)

<400>  83
atg cta atc acc ccg agg ctg cgg cca atc gcg gcg cgc gcc gag ggc         48
Met Leu Ile Thr Pro Arg Leu Arg Pro Ile Ala Ala Arg Ala Glu Gly           
1               5                   10                  15                

ccg ggc cat gga tct cgg acg ctg gct tgc gcg caa gct cgc gtc cgg         96
Pro Gly His Gly Ser Arg Thr Leu Ala Cys Ala Gln Ala Arg Val Arg           
            20                  25                  30                    

gcg gcc cca ggc ttc ttg caa gcg gcg cgg cgg gcc tgc gag gag ccc        144
Ala Ala Pro Gly Phe Leu Gln Ala Ala Arg Arg Ala Cys Glu Glu Pro           
        35                  40                  45                        

cag ccg gcc cgc gcc ttt gca ccg tgc tcc atg cat ccg gag ccc gcc        192
Gln Pro Ala Arg Ala Phe Ala Pro Cys Ser Met His Pro Glu Pro Ala           
    50                  55                  60                            

ccg ccc ccg aac agc aac agc ccc gag ctt ccc ctc ggc gga ggc agc        240
Pro Pro Pro Asn Ser Asn Ser Pro Glu Leu Pro Leu Gly Gly Gly Ser           
65                  70                  75                  80            

acc acc agc ggc agc cgc cgg agc cgc cgc cgc agc ggg gac ggg gag        288
Thr Thr Ser Gly Ser Arg Arg Ser Arg Arg Arg Ser Gly Asp Gly Glu           
                85                  90                  95                

ccc ccg ggg tcg ccg ccc ccg cca gcc gcc gtc acc tac ccg gac tgg        336
Pro Pro Gly Ser Pro Pro Pro Pro Ala Ala Val Thr Tyr Pro Asp Trp           
            100                 105                 110                   

atc ggc cag act tac tcc gag gtg atg agc ctc aac gag cac tcg atg        384
Ile Gly Gln Thr Tyr Ser Glu Val Met Ser Leu Asn Glu His Ser Met           
        115                 120                 125                       

cag gcg ctg tcc tgg cgc aag ctc tac ttg agc cgc gcc aag ctc aaa        432
Gln Ala Leu Ser Trp Arg Lys Leu Tyr Leu Ser Arg Ala Lys Leu Lys           
    130                 135                 140                           

gcc tcc agc cgg acc tct gct ctg ctc tcc ggc ttc gcc atg gtg gcg        480
Ala Ser Ser Arg Thr Ser Ala Leu Leu Ser Gly Phe Ala Met Val Ala           
145                 150                 155                 160           

atg gtg gag gta cag ctg gat gcc gac cac gac tac ccg cca ggg ctg        528
Met Val Glu Val Gln Leu Asp Ala Asp His Asp Tyr Pro Pro Gly Leu           
                165                 170                 175               

ctg atc gcc ttc agc gcc tgc act aca gtg tta gtg gcc gta cac ctg        576
Leu Ile Ala Phe Ser Ala Cys Thr Thr Val Leu Val Ala Val His Leu           
            180                 185                 190                   

ttt gcg ctc atg atc agc acc tgc atc ctg ccc aac atc gag gcg gtg        624
Phe Ala Leu Met Ile Ser Thr Cys Ile Leu Pro Asn Ile Glu Ala Val           
        195                 200                 205                       

agc aac gtg cat aac ctc aac tcg gtc aag gag tcg ccc cat gaa cgc        672
Ser Asn Val His Asn Leu Asn Ser Val Lys Glu Ser Pro His Glu Arg           
    210                 215                 220                           

atg cac cgc cac atc gag cta gcc tgg gcc ttc tcc act gtc att ggc        720
Met His Arg His Ile Glu Leu Ala Trp Ala Phe Ser Thr Val Ile Gly           
225                 230                 235                 240           

aca ctc ctc ttt ctg gct gag gta gtg ctg ctc tgc tgg gtc aag ttt        768
Thr Leu Leu Phe Leu Ala Glu Val Val Leu Leu Cys Trp Val Lys Phe           
                245                 250                 255               

ttg ccc ctc aag aag cag cca ggg cag ccc cgg ccc acc agc aag ccc        816
Leu Pro Leu Lys Lys Gln Pro Gly Gln Pro Arg Pro Thr Ser Lys Pro           
            260                 265                 270                   

cca gct ggc agc gct gtt gcc agc gtc aac ggc agc agc act ggc ggc        864
Pro Ala Gly Ser Ala Val Ala Ser Val Asn Gly Ser Ser Thr Gly Gly           
        275                 280                 285                       

atc acc ccc ggc cag gct gct gcc att gcc tcc acc acc atc atg gtc        912
Ile Thr Pro Gly Gln Ala Ala Ala Ile Ala Ser Thr Thr Ile Met Val           
    290                 295                 300                           

ccc ttc ggc ctg gtc ttt atc gtc ttt gcc gtc cac ttc tac cgc tca        960
Pro Phe Gly Leu Val Phe Ile Val Phe Ala Val His Phe Tyr Arg Ser           
305                 310                 315                 320           

ctg gtc agc cat aaa acg gac cgg cag ttc cag gag ctc aac gag ctg       1008
Leu Val Ser His Lys Thr Asp Arg Gln Phe Gln Glu Leu Asn Glu Leu           
                325                 330                 335               

gcc gag ttt gct cgc ctg cag gac cag ctg gac cac aga ggg gat cac       1056
Ala Glu Phe Ala Arg Leu Gln Asp Gln Leu Asp His Arg Gly Asp His           
            340                 345                 350                   

ccc ctg acg ccc agc agt cac tat gca taa                               1086
Pro Leu Thr Pro Ser Ser His Tyr Ala                                       
        355                 360                                           


<210>  84
<211>  361
<212>  PRT
<213>  Canis familiaris

<400>  84

Met Leu Ile Thr Pro Arg Leu Arg Pro Ile Ala Ala Arg Ala Glu Gly 
1               5                   10                  15      


Pro Gly His Gly Ser Arg Thr Leu Ala Cys Ala Gln Ala Arg Val Arg 
            20                  25                  30          


Ala Ala Pro Gly Phe Leu Gln Ala Ala Arg Arg Ala Cys Glu Glu Pro 
        35                  40                  45              


Gln Pro Ala Arg Ala Phe Ala Pro Cys Ser Met His Pro Glu Pro Ala 
    50                  55                  60                  


Pro Pro Pro Asn Ser Asn Ser Pro Glu Leu Pro Leu Gly Gly Gly Ser 
65                  70                  75                  80  


Thr Thr Ser Gly Ser Arg Arg Ser Arg Arg Arg Ser Gly Asp Gly Glu 
                85                  90                  95      


Pro Pro Gly Ser Pro Pro Pro Pro Ala Ala Val Thr Tyr Pro Asp Trp 
            100                 105                 110         


Ile Gly Gln Thr Tyr Ser Glu Val Met Ser Leu Asn Glu His Ser Met 
        115                 120                 125             


Gln Ala Leu Ser Trp Arg Lys Leu Tyr Leu Ser Arg Ala Lys Leu Lys 
    130                 135                 140                 


Ala Ser Ser Arg Thr Ser Ala Leu Leu Ser Gly Phe Ala Met Val Ala 
145                 150                 155                 160 


Met Val Glu Val Gln Leu Asp Ala Asp His Asp Tyr Pro Pro Gly Leu 
                165                 170                 175     


Leu Ile Ala Phe Ser Ala Cys Thr Thr Val Leu Val Ala Val His Leu 
            180                 185                 190         


Phe Ala Leu Met Ile Ser Thr Cys Ile Leu Pro Asn Ile Glu Ala Val 
        195                 200                 205             


Ser Asn Val His Asn Leu Asn Ser Val Lys Glu Ser Pro His Glu Arg 
    210                 215                 220                 


Met His Arg His Ile Glu Leu Ala Trp Ala Phe Ser Thr Val Ile Gly 
225                 230                 235                 240 


Thr Leu Leu Phe Leu Ala Glu Val Val Leu Leu Cys Trp Val Lys Phe 
                245                 250                 255     


Leu Pro Leu Lys Lys Gln Pro Gly Gln Pro Arg Pro Thr Ser Lys Pro 
            260                 265                 270         


Pro Ala Gly Ser Ala Val Ala Ser Val Asn Gly Ser Ser Thr Gly Gly 
        275                 280                 285             


Ile Thr Pro Gly Gln Ala Ala Ala Ile Ala Ser Thr Thr Ile Met Val 
    290                 295                 300                 


Pro Phe Gly Leu Val Phe Ile Val Phe Ala Val His Phe Tyr Arg Ser 
305                 310                 315                 320 


Leu Val Ser His Lys Thr Asp Arg Gln Phe Gln Glu Leu Asn Glu Leu 
                325                 330                 335     


Ala Glu Phe Ala Arg Leu Gln Asp Gln Leu Asp His Arg Gly Asp His 
            340                 345                 350         


Pro Leu Thr Pro Ser Ser His Tyr Ala 
        355                 360     


<210>  85
<211>  37
<212>  PRT
<213>  Mus musculus


<220>
<221>  MISC_FEATURE
<223>  Putative ORAI1 ECL2 domain sequence

<400>  85

Lys Phe Leu Pro Leu Lys Arg Gln Ala Gly Gln Pro Ser Pro Thr Lys 
1               5                   10                  15      


Pro Pro Ala Glu Ser Val Ile Val Ala Asn His Ser Asp Ser Ser Gly 
            20                  25                  30          


Ile Thr Pro Gly Glu 
        35          


<210>  86
<211>  27
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Forward primer sequence

<400>  86
ggtcgacatg catccggagc ccgcccc                                           27


<210>  87
<211>  43
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Reverse primer sequence

<400>  87
ggcggtgcat gcgctcatgt ggtgactcct tgaccgagtt gag                         43


<210>  88
<211>  73
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Forward primer sequence

<400>  88
cgcatgcacc gccacatcga gctggcctgg gccttctcca ccgtcatcgg cacgctgctc       60

ttcctagctg agg                                                          73


<210>  89
<211>  66
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Reverse primer sequence

<400>  89
cgcggccgcc taggcatagt ggctgccggg cgtcaggggg tggtcccctc tgtggtccag       60

ctggtc                                                                  66


<210>  90
<211>  909
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  hORAI1/mORAI1 ECL2 chimeric sequence


<220>
<221>  CDS
<222>  (1)..(909)

<400>  90
atg cat ccg gag ccc gcc ccg ccc ccg agc cgc agc agt ccc gag ctt         48
Met His Pro Glu Pro Ala Pro Pro Pro Ser Arg Ser Ser Pro Glu Leu           
1               5                   10                  15                

ccc cca agc ggc ggc agc acc acc agc ggc agc cgc cgg agc cgc cgc         96
Pro Pro Ser Gly Gly Ser Thr Thr Ser Gly Ser Arg Arg Ser Arg Arg           
            20                  25                  30                    

cgc agc ggg gac ggg gag ccc ccg ggg gcc ccg cca ccg ccg ccg tcc        144
Arg Ser Gly Asp Gly Glu Pro Pro Gly Ala Pro Pro Pro Pro Pro Ser           
        35                  40                  45                        

gcc gtc acc tac ccg gac tgg atc ggc cag agt tac tcc gag gtg atg        192
Ala Val Thr Tyr Pro Asp Trp Ile Gly Gln Ser Tyr Ser Glu Val Met           
    50                  55                  60                            

agc ctc aac gag cac tcc atg cag gcg ctg tcc tgg cgc aag ctc tac        240
Ser Leu Asn Glu His Ser Met Gln Ala Leu Ser Trp Arg Lys Leu Tyr           
65                  70                  75                  80            

ttg agc cgc gcc aag ctt aaa gcc tcc agc cgg acc tcg gct ctg ctc        288
Leu Ser Arg Ala Lys Leu Lys Ala Ser Ser Arg Thr Ser Ala Leu Leu           
                85                  90                  95                

tcc ggc ttc gcc atg gtg gca atg gtg gag gtg cag ctg gac gct gac        336
Ser Gly Phe Ala Met Val Ala Met Val Glu Val Gln Leu Asp Ala Asp           
            100                 105                 110                   

cac gac tac cca ccg ggg ctg ctc atc gcc ttc agt gcc tgc acc aca        384
His Asp Tyr Pro Pro Gly Leu Leu Ile Ala Phe Ser Ala Cys Thr Thr           
        115                 120                 125                       

gtg ctg gtg gct gtg cac ctg ttt gcg ctc atg atc agc acc tgc atc        432
Val Leu Val Ala Val His Leu Phe Ala Leu Met Ile Ser Thr Cys Ile           
    130                 135                 140                           

ctg ccc aac atc gag gcg gtg agc aac gtg cac aat ctc aac tcg gtc        480
Leu Pro Asn Ile Glu Ala Val Ser Asn Val His Asn Leu Asn Ser Val           
145                 150                 155                 160           

aag gag tcc ccc cat gag cgc atg cac cgc cac atc gag ctg gcc tgg        528
Lys Glu Ser Pro His Glu Arg Met His Arg His Ile Glu Leu Ala Trp           
                165                 170                 175               

gcc ttc tcc acc gtc atc ggc acg ctg ctc ttc cta gct gag gtg gtg        576
Ala Phe Ser Thr Val Ile Gly Thr Leu Leu Phe Leu Ala Glu Val Val           
            180                 185                 190                   

ctg ctc tgc tgg gtc aag ttc ttg ccc ctc aag agg caa gcg gga cag        624
Leu Leu Cys Trp Val Lys Phe Leu Pro Leu Lys Arg Gln Ala Gly Gln           
        195                 200                 205                       

cca agc ccc acc aag cct ccc gct gaa tca gtc atc gtc gcc aac cac        672
Pro Ser Pro Thr Lys Pro Pro Ala Glu Ser Val Ile Val Ala Asn His           
    210                 215                 220                           

agc gac agc agc ggc atc acc ccg ggc cag gca gct gcc atc gct tcg        720
Ser Asp Ser Ser Gly Ile Thr Pro Gly Gln Ala Ala Ala Ile Ala Ser           
225                 230                 235                 240           

acc acc atc atg gtg ccc ttc ggc ctg atc ttt atc gtc ttc gcc gtc        768
Thr Thr Ile Met Val Pro Phe Gly Leu Ile Phe Ile Val Phe Ala Val           
                245                 250                 255               

cac ttc tac cgc tca ctg gtt agc cat aag acc gac cga cag ttc cag        816
His Phe Tyr Arg Ser Leu Val Ser His Lys Thr Asp Arg Gln Phe Gln           
            260                 265                 270                   

gag ctc aac gag ctg gcg gag ttt gcc cgc tta cag gac cag ctg gac        864
Glu Leu Asn Glu Leu Ala Glu Phe Ala Arg Leu Gln Asp Gln Leu Asp           
        275                 280                 285                       

cac aga ggg gac cac ccc ctg acg ccc ggc agc cac tat gcc tag            909
His Arg Gly Asp His Pro Leu Thr Pro Gly Ser His Tyr Ala                   
    290                 295                 300                           


<210>  91
<211>  302
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  91

Met His Pro Glu Pro Ala Pro Pro Pro Ser Arg Ser Ser Pro Glu Leu 
1               5                   10                  15      


Pro Pro Ser Gly Gly Ser Thr Thr Ser Gly Ser Arg Arg Ser Arg Arg 
            20                  25                  30          


Arg Ser Gly Asp Gly Glu Pro Pro Gly Ala Pro Pro Pro Pro Pro Ser 
        35                  40                  45              


Ala Val Thr Tyr Pro Asp Trp Ile Gly Gln Ser Tyr Ser Glu Val Met 
    50                  55                  60                  


Ser Leu Asn Glu His Ser Met Gln Ala Leu Ser Trp Arg Lys Leu Tyr 
65                  70                  75                  80  


Leu Ser Arg Ala Lys Leu Lys Ala Ser Ser Arg Thr Ser Ala Leu Leu 
                85                  90                  95      


Ser Gly Phe Ala Met Val Ala Met Val Glu Val Gln Leu Asp Ala Asp 
            100                 105                 110         


His Asp Tyr Pro Pro Gly Leu Leu Ile Ala Phe Ser Ala Cys Thr Thr 
        115                 120                 125             


Val Leu Val Ala Val His Leu Phe Ala Leu Met Ile Ser Thr Cys Ile 
    130                 135                 140                 


Leu Pro Asn Ile Glu Ala Val Ser Asn Val His Asn Leu Asn Ser Val 
145                 150                 155                 160 


Lys Glu Ser Pro His Glu Arg Met His Arg His Ile Glu Leu Ala Trp 
                165                 170                 175     


Ala Phe Ser Thr Val Ile Gly Thr Leu Leu Phe Leu Ala Glu Val Val 
            180                 185                 190         


Leu Leu Cys Trp Val Lys Phe Leu Pro Leu Lys Arg Gln Ala Gly Gln 
        195                 200                 205             


Pro Ser Pro Thr Lys Pro Pro Ala Glu Ser Val Ile Val Ala Asn His 
    210                 215                 220                 


Ser Asp Ser Ser Gly Ile Thr Pro Gly Gln Ala Ala Ala Ile Ala Ser 
225                 230                 235                 240 


Thr Thr Ile Met Val Pro Phe Gly Leu Ile Phe Ile Val Phe Ala Val 
                245                 250                 255     


His Phe Tyr Arg Ser Leu Val Ser His Lys Thr Asp Arg Gln Phe Gln 
            260                 265                 270         


Glu Leu Asn Glu Leu Ala Glu Phe Ala Arg Leu Gln Asp Gln Leu Asp 
        275                 280                 285             


His Arg Gly Asp His Pro Leu Thr Pro Gly Ser His Tyr Ala 
    290                 295                 300         


<210>  92
<211>  38
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Forward primer sequence

<400>  92
ggatcctgaa ccaccatgca tccggagcct gccccgcc                               38


<210>  93
<211>  64
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Reverse primer sequence

<400>  93
gggcttgctg gtgggccttg gctggcctgg ctgcttcttg agaggtaaga acttgaccca       60

gcag                                                                    64


<210>  94
<211>  65
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Reverse primer sequence

<400>  94
ggtgatgccg ctggtgctga cgttggctgc tgcgccactg gcggggggct tgctggtggg       60

ccttg                                                                   65


<210>  95
<211>  65
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Reverse primer sequence

<400>  95
ggaaccatga tggcggtgga ggcaatggct gccgcctcac ccggggtgat gccgctggtg       60

ctgac                                                                   65


<210>  96
<211>  912
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  mORAI1/hORAI1 ECL2 chimeric sequence


<220>
<221>  CDS
<222>  (1)..(912)

<400>  96
atg cat ccg gag cct gcc ccg ccc ccg agt cac agc aat ccg gag ctt         48
Met His Pro Glu Pro Ala Pro Pro Pro Ser His Ser Asn Pro Glu Leu           
1               5                   10                  15                

ccc gtg agc ggc ggc agc agc act agc ggc agc cgc cgg agc cgc cgc         96
Pro Val Ser Gly Gly Ser Ser Thr Ser Gly Ser Arg Arg Ser Arg Arg           
            20                  25                  30                    

cgc agc ggg gac ggg gag ccc tcg ggg gcc cca ccg ctg ccg ccg ccg        144
Arg Ser Gly Asp Gly Glu Pro Ser Gly Ala Pro Pro Leu Pro Pro Pro           
        35                  40                  45                        

cca ccc gcc gtc agc tac ccg gac tgg atc ggc cag agt tac tcc gag        192
Pro Pro Ala Val Ser Tyr Pro Asp Trp Ile Gly Gln Ser Tyr Ser Glu           
    50                  55                  60                            

gtg atg agc ctc aac gag cac tcg atg cag gcg ctg tcc tgg cgc aag        240
Val Met Ser Leu Asn Glu His Ser Met Gln Ala Leu Ser Trp Arg Lys           
65                  70                  75                  80            

ctc tac tta agc cgc gcc aag ctc aaa gct tcc agc cgg acc tcg gct        288
Leu Tyr Leu Ser Arg Ala Lys Leu Lys Ala Ser Ser Arg Thr Ser Ala           
                85                  90                  95                

ctg ctc tcc ggc ttc gcc atg gta gcg atg gtg gaa gtc cag ctg gac        336
Leu Leu Ser Gly Phe Ala Met Val Ala Met Val Glu Val Gln Leu Asp           
            100                 105                 110                   

aca gac cat gac tac cca cca ggg ttg ctc atc gtc ttt agt gcc tgc        384
Thr Asp His Asp Tyr Pro Pro Gly Leu Leu Ile Val Phe Ser Ala Cys           
        115                 120                 125                       

acc aca gtg cta gtg gcc gtg cac ctg ttt gcc ctc atg atc agc acc        432
Thr Thr Val Leu Val Ala Val His Leu Phe Ala Leu Met Ile Ser Thr           
    130                 135                 140                           

tgc atc ctg ccc aac atc gag gct gtg agc aac gtc cac aac ctc aac        480
Cys Ile Leu Pro Asn Ile Glu Ala Val Ser Asn Val His Asn Leu Asn           
145                 150                 155                 160           

tcg gtc aaa gag tca ccc cac gag cgc atg cat cgc cac atc gag ctg        528
Ser Val Lys Glu Ser Pro His Glu Arg Met His Arg His Ile Glu Leu           
                165                 170                 175               

gcc tgg gcc ttc tcc acg gtc atc ggg acg ctg ctt ttc cta gca gag        576
Ala Trp Ala Phe Ser Thr Val Ile Gly Thr Leu Leu Phe Leu Ala Glu           
            180                 185                 190                   

gtc gtg ctg ctc tgc tgg gtc aag ttc tta cct ctc aag aag cag cca        624
Val Val Leu Leu Cys Trp Val Lys Phe Leu Pro Leu Lys Lys Gln Pro           
        195                 200                 205                       

ggc cag cca agg ccc acc agc aag ccc ccc gcc agt ggc gca gca gcc        672
Gly Gln Pro Arg Pro Thr Ser Lys Pro Pro Ala Ser Gly Ala Ala Ala           
    210                 215                 220                           

aac gtc agc acc agc ggc atc acc ccg ggt gag gcg gca gcc att gcc        720
Asn Val Ser Thr Ser Gly Ile Thr Pro Gly Glu Ala Ala Ala Ile Ala           
225                 230                 235                 240           

tcc acc gcc atc atg gtt ccc tgt ggc ctg gtt ttc atc gtc ttt gct        768
Ser Thr Ala Ile Met Val Pro Cys Gly Leu Val Phe Ile Val Phe Ala           
                245                 250                 255               

gtt cac ttc tac cgc tcc ctg gtc agc cat aag acg gac cgg cag ttc        816
Val His Phe Tyr Arg Ser Leu Val Ser His Lys Thr Asp Arg Gln Phe           
            260                 265                 270                   

cag gag ctc aat gag ctg gcc gag ttt gcc cgc ttg cag gac cag ctg        864
Gln Glu Leu Asn Glu Leu Ala Glu Phe Ala Arg Leu Gln Asp Gln Leu           
        275                 280                 285                       

gac cac aga ggg gac cat tct cta aca ccg ggc acc cac tat gcc taa        912
Asp His Arg Gly Asp His Ser Leu Thr Pro Gly Thr His Tyr Ala               
    290                 295                 300                           


<210>  97
<211>  303
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  97

Met His Pro Glu Pro Ala Pro Pro Pro Ser His Ser Asn Pro Glu Leu 
1               5                   10                  15      


Pro Val Ser Gly Gly Ser Ser Thr Ser Gly Ser Arg Arg Ser Arg Arg 
            20                  25                  30          


Arg Ser Gly Asp Gly Glu Pro Ser Gly Ala Pro Pro Leu Pro Pro Pro 
        35                  40                  45              


Pro Pro Ala Val Ser Tyr Pro Asp Trp Ile Gly Gln Ser Tyr Ser Glu 
    50                  55                  60                  


Val Met Ser Leu Asn Glu His Ser Met Gln Ala Leu Ser Trp Arg Lys 
65                  70                  75                  80  


Leu Tyr Leu Ser Arg Ala Lys Leu Lys Ala Ser Ser Arg Thr Ser Ala 
                85                  90                  95      


Leu Leu Ser Gly Phe Ala Met Val Ala Met Val Glu Val Gln Leu Asp 
            100                 105                 110         


Thr Asp His Asp Tyr Pro Pro Gly Leu Leu Ile Val Phe Ser Ala Cys 
        115                 120                 125             


Thr Thr Val Leu Val Ala Val His Leu Phe Ala Leu Met Ile Ser Thr 
    130                 135                 140                 


Cys Ile Leu Pro Asn Ile Glu Ala Val Ser Asn Val His Asn Leu Asn 
145                 150                 155                 160 


Ser Val Lys Glu Ser Pro His Glu Arg Met His Arg His Ile Glu Leu 
                165                 170                 175     


Ala Trp Ala Phe Ser Thr Val Ile Gly Thr Leu Leu Phe Leu Ala Glu 
            180                 185                 190         


Val Val Leu Leu Cys Trp Val Lys Phe Leu Pro Leu Lys Lys Gln Pro 
        195                 200                 205             


Gly Gln Pro Arg Pro Thr Ser Lys Pro Pro Ala Ser Gly Ala Ala Ala 
    210                 215                 220                 


Asn Val Ser Thr Ser Gly Ile Thr Pro Gly Glu Ala Ala Ala Ile Ala 
225                 230                 235                 240 


Ser Thr Ala Ile Met Val Pro Cys Gly Leu Val Phe Ile Val Phe Ala 
                245                 250                 255     


Val His Phe Tyr Arg Ser Leu Val Ser His Lys Thr Asp Arg Gln Phe 
            260                 265                 270         


Gln Glu Leu Asn Glu Leu Ala Glu Phe Ala Arg Leu Gln Asp Gln Leu 
        275                 280                 285             


Asp His Arg Gly Asp His Ser Leu Thr Pro Gly Thr His Tyr Ala 
    290                 295                 300             


<210>  98
<211>  5
<212>  PRT
<213>  Mus musculus


<220>
<221>  MISC_FEATURE
<223>  215-219 of SEQ ID NO:72

<400>  98

Lys Pro Pro Ala Glu 
1               5   


<210>  99
<211>  5
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<223>  213-217 of SEQ ID NO:2

<400>  99

Ser Lys Pro Pro Ala 
1               5   


<210>  100
<211>  53
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Forward sequence primer

<400>  100
gggacagcca agccccacca gcaagccccc tgcatcagtc atcgtcgcca acc              53


<210>  101
<211>  53
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Reverse sequence primer

<400>  101
ggttggcgac gatgactgat gcagggggct tgctggtggg gcttggctgt ccc              53


<210>  102
<211>  909
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  hORAI1/mORAI1 ECL2 (SKPPA) sequence


<220>
<221>  CDS
<222>  (1)..(909)

<400>  102
atg cat ccg gag ccc gcc ccg ccc ccg agc cgc agc agt ccc gag ctt         48
Met His Pro Glu Pro Ala Pro Pro Pro Ser Arg Ser Ser Pro Glu Leu           
1               5                   10                  15                

ccc cca agc ggc ggc agc acc acc agc ggc agc cgc cgg agc cgc cgc         96
Pro Pro Ser Gly Gly Ser Thr Thr Ser Gly Ser Arg Arg Ser Arg Arg           
            20                  25                  30                    

cgc agc ggg gac ggg gag ccc ccg ggg gcc ccg cca ccg ccg ccg tcc        144
Arg Ser Gly Asp Gly Glu Pro Pro Gly Ala Pro Pro Pro Pro Pro Ser           
        35                  40                  45                        

gcc gtc acc tac ccg gac tgg atc ggc cag agt tac tcc gag gtg atg        192
Ala Val Thr Tyr Pro Asp Trp Ile Gly Gln Ser Tyr Ser Glu Val Met           
    50                  55                  60                            

agc ctc aac gag cac tcc atg cag gcg ctg tcc tgg cgc aag ctc tac        240
Ser Leu Asn Glu His Ser Met Gln Ala Leu Ser Trp Arg Lys Leu Tyr           
65                  70                  75                  80            

ttg agc cgc gcc aag ctt aaa gcc tcc agc cgg acc tcg gct ctg ctc        288
Leu Ser Arg Ala Lys Leu Lys Ala Ser Ser Arg Thr Ser Ala Leu Leu           
                85                  90                  95                

tcc ggc ttc gcc atg gtg gca atg gtg gag gtg cag ctg gac gct gac        336
Ser Gly Phe Ala Met Val Ala Met Val Glu Val Gln Leu Asp Ala Asp           
            100                 105                 110                   

cac gac tac cca ccg ggg ctg ctc atc gcc ttc agt gcc tgc acc aca        384
His Asp Tyr Pro Pro Gly Leu Leu Ile Ala Phe Ser Ala Cys Thr Thr           
        115                 120                 125                       

gtg ctg gtg gct gtg cac ctg ttt gcg ctc atg atc agc acc tgc atc        432
Val Leu Val Ala Val His Leu Phe Ala Leu Met Ile Ser Thr Cys Ile           
    130                 135                 140                           

ctg ccc aac atc gag gcg gtg agc aac gtg cac aat ctc aac tcg gtc        480
Leu Pro Asn Ile Glu Ala Val Ser Asn Val His Asn Leu Asn Ser Val           
145                 150                 155                 160           

aag gag tcc ccc cat gag cgc atg cac cgc cac atc gag ctg gcc tgg        528
Lys Glu Ser Pro His Glu Arg Met His Arg His Ile Glu Leu Ala Trp           
                165                 170                 175               

gcc ttc tcc acc gtc atc ggc acg ctg ctc ttc cta gct gag gtg gtg        576
Ala Phe Ser Thr Val Ile Gly Thr Leu Leu Phe Leu Ala Glu Val Val           
            180                 185                 190                   

ctg ctc tgc tgg gtc aag ttc ttg ccc ctc aag agg caa gcg gga cag        624
Leu Leu Cys Trp Val Lys Phe Leu Pro Leu Lys Arg Gln Ala Gly Gln           
        195                 200                 205                       

cca agc ccc acc agc aag ccc cct gca tca gtc atc gtc gcc aac cac        672
Pro Ser Pro Thr Ser Lys Pro Pro Ala Ser Val Ile Val Ala Asn His           
    210                 215                 220                           

agc gac agc agc ggc atc acc ccg ggc cag gca gct gcc atc gct tcg        720
Ser Asp Ser Ser Gly Ile Thr Pro Gly Gln Ala Ala Ala Ile Ala Ser           
225                 230                 235                 240           

acc acc atc atg gtg ccc ttc ggc ctg atc ttt atc gtc ttc gcc gtc        768
Thr Thr Ile Met Val Pro Phe Gly Leu Ile Phe Ile Val Phe Ala Val           
                245                 250                 255               

cac ttc tac cgc tca ctg gtt agc cat aag acc gac cga cag ttc cag        816
His Phe Tyr Arg Ser Leu Val Ser His Lys Thr Asp Arg Gln Phe Gln           
            260                 265                 270                   

gag ctc aac gag ctg gcg gag ttt gcc cgc tta cag gac cag ctg gac        864
Glu Leu Asn Glu Leu Ala Glu Phe Ala Arg Leu Gln Asp Gln Leu Asp           
        275                 280                 285                       

cac aga ggg gac cac ccc ctg acg ccc ggc agc cac tat gcc tag            909
His Arg Gly Asp His Pro Leu Thr Pro Gly Ser His Tyr Ala                   
    290                 295                 300                           


<210>  103
<211>  302
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  103

Met His Pro Glu Pro Ala Pro Pro Pro Ser Arg Ser Ser Pro Glu Leu 
1               5                   10                  15      


Pro Pro Ser Gly Gly Ser Thr Thr Ser Gly Ser Arg Arg Ser Arg Arg 
            20                  25                  30          


Arg Ser Gly Asp Gly Glu Pro Pro Gly Ala Pro Pro Pro Pro Pro Ser 
        35                  40                  45              


Ala Val Thr Tyr Pro Asp Trp Ile Gly Gln Ser Tyr Ser Glu Val Met 
    50                  55                  60                  


Ser Leu Asn Glu His Ser Met Gln Ala Leu Ser Trp Arg Lys Leu Tyr 
65                  70                  75                  80  


Leu Ser Arg Ala Lys Leu Lys Ala Ser Ser Arg Thr Ser Ala Leu Leu 
                85                  90                  95      


Ser Gly Phe Ala Met Val Ala Met Val Glu Val Gln Leu Asp Ala Asp 
            100                 105                 110         


His Asp Tyr Pro Pro Gly Leu Leu Ile Ala Phe Ser Ala Cys Thr Thr 
        115                 120                 125             


Val Leu Val Ala Val His Leu Phe Ala Leu Met Ile Ser Thr Cys Ile 
    130                 135                 140                 


Leu Pro Asn Ile Glu Ala Val Ser Asn Val His Asn Leu Asn Ser Val 
145                 150                 155                 160 


Lys Glu Ser Pro His Glu Arg Met His Arg His Ile Glu Leu Ala Trp 
                165                 170                 175     


Ala Phe Ser Thr Val Ile Gly Thr Leu Leu Phe Leu Ala Glu Val Val 
            180                 185                 190         


Leu Leu Cys Trp Val Lys Phe Leu Pro Leu Lys Arg Gln Ala Gly Gln 
        195                 200                 205             


Pro Ser Pro Thr Ser Lys Pro Pro Ala Ser Val Ile Val Ala Asn His 
    210                 215                 220                 


Ser Asp Ser Ser Gly Ile Thr Pro Gly Gln Ala Ala Ala Ile Ala Ser 
225                 230                 235                 240 


Thr Thr Ile Met Val Pro Phe Gly Leu Ile Phe Ile Val Phe Ala Val 
                245                 250                 255     


His Phe Tyr Arg Ser Leu Val Ser His Lys Thr Asp Arg Gln Phe Gln 
            260                 265                 270         


Glu Leu Asn Glu Leu Ala Glu Phe Ala Arg Leu Gln Asp Gln Leu Asp 
        275                 280                 285             


His Arg Gly Asp His Pro Leu Thr Pro Gly Ser His Tyr Ala 
    290                 295                 300         


<210>  104
<211>  39
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Forward sequence primer

<400>  104
cctcccgctg aatcaggcgc cgccgccaac cacagcgac                              39


<210>  105
<211>  39
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Reverse sequence primer

<400>  105
gtcgctgtgg ttggcggcgg cgcctgattc agcgggagg                              39


<210>  106
<211>  909
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  hORAI1/mORAI1 ECL2 (GAA) sequence


<220>
<221>  CDS
<222>  (1)..(909)

<400>  106
atg cat ccg gag ccc gcc ccg ccc ccg agc cgc agc agt ccc gag ctt         48
Met His Pro Glu Pro Ala Pro Pro Pro Ser Arg Ser Ser Pro Glu Leu           
1               5                   10                  15                

ccc cca agc ggc ggc agc acc acc agc ggc agc cgc cgg agc cgc cgc         96
Pro Pro Ser Gly Gly Ser Thr Thr Ser Gly Ser Arg Arg Ser Arg Arg           
            20                  25                  30                    

cgc agc ggg gac ggg gag ccc ccg ggg gcc ccg cca ccg ccg ccg tcc        144
Arg Ser Gly Asp Gly Glu Pro Pro Gly Ala Pro Pro Pro Pro Pro Ser           
        35                  40                  45                        

gcc gtc acc tac ccg gac tgg atc ggc cag agt tac tcc gag gtg atg        192
Ala Val Thr Tyr Pro Asp Trp Ile Gly Gln Ser Tyr Ser Glu Val Met           
    50                  55                  60                            

agc ctc aac gag cac tcc atg cag gcg ctg tcc tgg cgc aag ctc tac        240
Ser Leu Asn Glu His Ser Met Gln Ala Leu Ser Trp Arg Lys Leu Tyr           
65                  70                  75                  80            

ttg agc cgc gcc aag ctt aaa gcc tcc agc cgg acc tcg gct ctg ctc        288
Leu Ser Arg Ala Lys Leu Lys Ala Ser Ser Arg Thr Ser Ala Leu Leu           
                85                  90                  95                

tcc ggc ttc gcc atg gtg gca atg gtg gag gtg cag ctg gac gct gac        336
Ser Gly Phe Ala Met Val Ala Met Val Glu Val Gln Leu Asp Ala Asp           
            100                 105                 110                   

cac gac tac cca ccg ggg ctg ctc atc gcc ttc agt gcc tgc acc aca        384
His Asp Tyr Pro Pro Gly Leu Leu Ile Ala Phe Ser Ala Cys Thr Thr           
        115                 120                 125                       

gtg ctg gtg gct gtg cac ctg ttt gcg ctc atg atc agc acc tgc atc        432
Val Leu Val Ala Val His Leu Phe Ala Leu Met Ile Ser Thr Cys Ile           
    130                 135                 140                           

ctg ccc aac atc gag gcg gtg agc aac gtg cac aat ctc aac tcg gtc        480
Leu Pro Asn Ile Glu Ala Val Ser Asn Val His Asn Leu Asn Ser Val           
145                 150                 155                 160           

aag gag tcc ccc cat gag cgc atg cac cgc cac atc gag ctg gcc tgg        528
Lys Glu Ser Pro His Glu Arg Met His Arg His Ile Glu Leu Ala Trp           
                165                 170                 175               

gcc ttc tcc acc gtc atc ggc acg ctg ctc ttc cta gct gag gtg gtg        576
Ala Phe Ser Thr Val Ile Gly Thr Leu Leu Phe Leu Ala Glu Val Val           
            180                 185                 190                   

ctg ctc tgc tgg gtc aag ttc ttg ccc ctc aag agg caa gcg gga cag        624
Leu Leu Cys Trp Val Lys Phe Leu Pro Leu Lys Arg Gln Ala Gly Gln           
        195                 200                 205                       

cca agc ccc acc aag cct ccc gct gaa tca ggc gcc gcc gcc aac cac        672
Pro Ser Pro Thr Lys Pro Pro Ala Glu Ser Gly Ala Ala Ala Asn His           
    210                 215                 220                           

agc gac agc agc ggc atc acc ccg ggc cag gca gct gcc atc gct tcg        720
Ser Asp Ser Ser Gly Ile Thr Pro Gly Gln Ala Ala Ala Ile Ala Ser           
225                 230                 235                 240           

acc acc atc atg gtg ccc ttc ggc ctg atc ttt atc gtc ttc gcc gtc        768
Thr Thr Ile Met Val Pro Phe Gly Leu Ile Phe Ile Val Phe Ala Val           
                245                 250                 255               

cac ttc tac cgc tca ctg gtt agc cat aag acc gac cga cag ttc cag        816
His Phe Tyr Arg Ser Leu Val Ser His Lys Thr Asp Arg Gln Phe Gln           
            260                 265                 270                   

gag ctc aac gag ctg gcg gag ttt gcc cgc tta cag gac cag ctg gac        864
Glu Leu Asn Glu Leu Ala Glu Phe Ala Arg Leu Gln Asp Gln Leu Asp           
        275                 280                 285                       

cac aga ggg gac cac ccc ctg acg ccc ggc agc cac tat gcc tag            909
His Arg Gly Asp His Pro Leu Thr Pro Gly Ser His Tyr Ala                   
    290                 295                 300                           


<210>  107
<211>  302
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  107

Met His Pro Glu Pro Ala Pro Pro Pro Ser Arg Ser Ser Pro Glu Leu 
1               5                   10                  15      


Pro Pro Ser Gly Gly Ser Thr Thr Ser Gly Ser Arg Arg Ser Arg Arg 
            20                  25                  30          


Arg Ser Gly Asp Gly Glu Pro Pro Gly Ala Pro Pro Pro Pro Pro Ser 
        35                  40                  45              


Ala Val Thr Tyr Pro Asp Trp Ile Gly Gln Ser Tyr Ser Glu Val Met 
    50                  55                  60                  


Ser Leu Asn Glu His Ser Met Gln Ala Leu Ser Trp Arg Lys Leu Tyr 
65                  70                  75                  80  


Leu Ser Arg Ala Lys Leu Lys Ala Ser Ser Arg Thr Ser Ala Leu Leu 
                85                  90                  95      


Ser Gly Phe Ala Met Val Ala Met Val Glu Val Gln Leu Asp Ala Asp 
            100                 105                 110         


His Asp Tyr Pro Pro Gly Leu Leu Ile Ala Phe Ser Ala Cys Thr Thr 
        115                 120                 125             


Val Leu Val Ala Val His Leu Phe Ala Leu Met Ile Ser Thr Cys Ile 
    130                 135                 140                 


Leu Pro Asn Ile Glu Ala Val Ser Asn Val His Asn Leu Asn Ser Val 
145                 150                 155                 160 


Lys Glu Ser Pro His Glu Arg Met His Arg His Ile Glu Leu Ala Trp 
                165                 170                 175     


Ala Phe Ser Thr Val Ile Gly Thr Leu Leu Phe Leu Ala Glu Val Val 
            180                 185                 190         


Leu Leu Cys Trp Val Lys Phe Leu Pro Leu Lys Arg Gln Ala Gly Gln 
        195                 200                 205             


Pro Ser Pro Thr Lys Pro Pro Ala Glu Ser Gly Ala Ala Ala Asn His 
    210                 215                 220                 


Ser Asp Ser Ser Gly Ile Thr Pro Gly Gln Ala Ala Ala Ile Ala Ser 
225                 230                 235                 240 


Thr Thr Ile Met Val Pro Phe Gly Leu Ile Phe Ile Val Phe Ala Val 
                245                 250                 255     


His Phe Tyr Arg Ser Leu Val Ser His Lys Thr Asp Arg Gln Phe Gln 
            260                 265                 270         


Glu Leu Asn Glu Leu Ala Glu Phe Ala Arg Leu Gln Asp Gln Leu Asp 
        275                 280                 285             


His Arg Gly Asp His Pro Leu Thr Pro Gly Ser His Tyr Ala 
    290                 295                 300         


<210>  108
<211>  6
<212>  PRT
<213>  Mus musculus


<220>
<221>  MISC_FEATURE
<223>  218 to 223 of SEQ ID NO:72 (mORAI1)

<400>  108

Ala Glu Ser Val Ile Val 
1               5       


<210>  109
<211>  6
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<223>  216 to 221 of SEQ ID NO:2 (hORAI1)

<400>  109

Pro Ala Ser Gly Ala Ala 
1               5       


<210>  110
<211>  47
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Forward primer sequence

<400>  110
cccaccaagc ctccccctgc atcaggcgcc gccgccaacc acagcga                     47


<210>  111
<211>  47
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Reverse primer sequence

<400>  111
tcgctgtggt tggcggcggc gcctgatgca gggggaggct tggtggg                     47


<210>  112
<211>  909
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  hORAI1/mORAI1 ECL2 (PASGAA) sequence


<220>
<221>  CDS
<222>  (1)..(909)

<400>  112
atg cat ccg gag ccc gcc ccg ccc ccg agc cgc agc agt ccc gag ctt         48
Met His Pro Glu Pro Ala Pro Pro Pro Ser Arg Ser Ser Pro Glu Leu           
1               5                   10                  15                

ccc cca agc ggc ggc agc acc acc agc ggc agc cgc cgg agc cgc cgc         96
Pro Pro Ser Gly Gly Ser Thr Thr Ser Gly Ser Arg Arg Ser Arg Arg           
            20                  25                  30                    

cgc agc ggg gac ggg gag ccc ccg ggg gcc ccg cca ccg ccg ccg tcc        144
Arg Ser Gly Asp Gly Glu Pro Pro Gly Ala Pro Pro Pro Pro Pro Ser           
        35                  40                  45                        

gcc gtc acc tac ccg gac tgg atc ggc cag agt tac tcc gag gtg atg        192
Ala Val Thr Tyr Pro Asp Trp Ile Gly Gln Ser Tyr Ser Glu Val Met           
    50                  55                  60                            

agc ctc aac gag cac tcc atg cag gcg ctg tcc tgg cgc aag ctc tac        240
Ser Leu Asn Glu His Ser Met Gln Ala Leu Ser Trp Arg Lys Leu Tyr           
65                  70                  75                  80            

ttg agc cgc gcc aag ctt aaa gcc tcc agc cgg acc tcg gct ctg ctc        288
Leu Ser Arg Ala Lys Leu Lys Ala Ser Ser Arg Thr Ser Ala Leu Leu           
                85                  90                  95                

tcc ggc ttc gcc atg gtg gca atg gtg gag gtg cag ctg gac gct gac        336
Ser Gly Phe Ala Met Val Ala Met Val Glu Val Gln Leu Asp Ala Asp           
            100                 105                 110                   

cac gac tac cca ccg ggg ctg ctc atc gcc ttc agt gcc tgc acc aca        384
His Asp Tyr Pro Pro Gly Leu Leu Ile Ala Phe Ser Ala Cys Thr Thr           
        115                 120                 125                       

gtg ctg gtg gct gtg cac ctg ttt gcg ctc atg atc agc acc tgc atc        432
Val Leu Val Ala Val His Leu Phe Ala Leu Met Ile Ser Thr Cys Ile           
    130                 135                 140                           

ctg ccc aac atc gag gcg gtg agc aac gtg cac aat ctc aac tcg gtc        480
Leu Pro Asn Ile Glu Ala Val Ser Asn Val His Asn Leu Asn Ser Val           
145                 150                 155                 160           

aag gag tcc ccc cat gag cgc atg cac cgc cac atc gag ctg gcc tgg        528
Lys Glu Ser Pro His Glu Arg Met His Arg His Ile Glu Leu Ala Trp           
                165                 170                 175               

gcc ttc tcc acc gtc atc ggc acg ctg ctc ttc cta gct gag gtg gtg        576
Ala Phe Ser Thr Val Ile Gly Thr Leu Leu Phe Leu Ala Glu Val Val           
            180                 185                 190                   

ctg ctc tgc tgg gtc aag ttc ttg ccc ctc aag agg caa gcg gga cag        624
Leu Leu Cys Trp Val Lys Phe Leu Pro Leu Lys Arg Gln Ala Gly Gln           
        195                 200                 205                       

cca agc ccc acc aag cct ccc cct gca tca ggc gcc gcc gcc aac cac        672
Pro Ser Pro Thr Lys Pro Pro Pro Ala Ser Gly Ala Ala Ala Asn His           
    210                 215                 220                           

agc gac agc agc ggc atc acc ccg ggc cag gca gct gcc atc gct tcg        720
Ser Asp Ser Ser Gly Ile Thr Pro Gly Gln Ala Ala Ala Ile Ala Ser           
225                 230                 235                 240           

acc acc atc atg gtg ccc ttc ggc ctg atc ttt atc gtc ttc gcc gtc        768
Thr Thr Ile Met Val Pro Phe Gly Leu Ile Phe Ile Val Phe Ala Val           
                245                 250                 255               

cac ttc tac cgc tca ctg gtt agc cat aag acc gac cga cag ttc cag        816
His Phe Tyr Arg Ser Leu Val Ser His Lys Thr Asp Arg Gln Phe Gln           
            260                 265                 270                   

gag ctc aac gag ctg gcg gag ttt gcc cgc tta cag gac cag ctg gac        864
Glu Leu Asn Glu Leu Ala Glu Phe Ala Arg Leu Gln Asp Gln Leu Asp           
        275                 280                 285                       

cac aga ggg gac cac ccc ctg acg ccc ggc agc cac tat gcc tag            909
His Arg Gly Asp His Pro Leu Thr Pro Gly Ser His Tyr Ala                   
    290                 295                 300                           


<210>  113
<211>  302
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  113

Met His Pro Glu Pro Ala Pro Pro Pro Ser Arg Ser Ser Pro Glu Leu 
1               5                   10                  15      


Pro Pro Ser Gly Gly Ser Thr Thr Ser Gly Ser Arg Arg Ser Arg Arg 
            20                  25                  30          


Arg Ser Gly Asp Gly Glu Pro Pro Gly Ala Pro Pro Pro Pro Pro Ser 
        35                  40                  45              


Ala Val Thr Tyr Pro Asp Trp Ile Gly Gln Ser Tyr Ser Glu Val Met 
    50                  55                  60                  


Ser Leu Asn Glu His Ser Met Gln Ala Leu Ser Trp Arg Lys Leu Tyr 
65                  70                  75                  80  


Leu Ser Arg Ala Lys Leu Lys Ala Ser Ser Arg Thr Ser Ala Leu Leu 
                85                  90                  95      


Ser Gly Phe Ala Met Val Ala Met Val Glu Val Gln Leu Asp Ala Asp 
            100                 105                 110         


His Asp Tyr Pro Pro Gly Leu Leu Ile Ala Phe Ser Ala Cys Thr Thr 
        115                 120                 125             


Val Leu Val Ala Val His Leu Phe Ala Leu Met Ile Ser Thr Cys Ile 
    130                 135                 140                 


Leu Pro Asn Ile Glu Ala Val Ser Asn Val His Asn Leu Asn Ser Val 
145                 150                 155                 160 


Lys Glu Ser Pro His Glu Arg Met His Arg His Ile Glu Leu Ala Trp 
                165                 170                 175     


Ala Phe Ser Thr Val Ile Gly Thr Leu Leu Phe Leu Ala Glu Val Val 
            180                 185                 190         


Leu Leu Cys Trp Val Lys Phe Leu Pro Leu Lys Arg Gln Ala Gly Gln 
        195                 200                 205             


Pro Ser Pro Thr Lys Pro Pro Pro Ala Ser Gly Ala Ala Ala Asn His 
    210                 215                 220                 


Ser Asp Ser Ser Gly Ile Thr Pro Gly Gln Ala Ala Ala Ile Ala Ser 
225                 230                 235                 240 


Thr Thr Ile Met Val Pro Phe Gly Leu Ile Phe Ile Val Phe Ala Val 
                245                 250                 255     


His Phe Tyr Arg Ser Leu Val Ser His Lys Thr Asp Arg Gln Phe Gln 
            260                 265                 270         


Glu Leu Asn Glu Leu Ala Glu Phe Ala Arg Leu Gln Asp Gln Leu Asp 
        275                 280                 285             


His Arg Gly Asp His Pro Leu Thr Pro Gly Ser His Tyr Ala 
    290                 295                 300         


<210>  114
<211>  36
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Forward primer sequence

<400>  114
gcgccgccgc caacgtcagc accagcagcg gcatca                                 36


<210>  115
<211>  36
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Reverse primer sequence

<400>  115
tgatgccgct gctggtgctg acgttggcgg cggcgc                                 36


<210>  116
<211>  909
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  hORAI1/mORAI1 ECL2  (VST) sequence


<220>
<221>  CDS
<222>  (1)..(909)

<400>  116
atg cat ccg gag ccc gcc ccg ccc ccg agc cgc agc agt ccc gag ctt         48
Met His Pro Glu Pro Ala Pro Pro Pro Ser Arg Ser Ser Pro Glu Leu           
1               5                   10                  15                

ccc cca agc ggc ggc agc acc acc agc ggc agc cgc cgg agc cgc cgc         96
Pro Pro Ser Gly Gly Ser Thr Thr Ser Gly Ser Arg Arg Ser Arg Arg           
            20                  25                  30                    

cgc agc ggg gac ggg gag ccc ccg ggg gcc ccg cca ccg ccg ccg tcc        144
Arg Ser Gly Asp Gly Glu Pro Pro Gly Ala Pro Pro Pro Pro Pro Ser           
        35                  40                  45                        

gcc gtc acc tac ccg gac tgg atc ggc cag agt tac tcc gag gtg atg        192
Ala Val Thr Tyr Pro Asp Trp Ile Gly Gln Ser Tyr Ser Glu Val Met           
    50                  55                  60                            

agc ctc aac gag cac tcc atg cag gcg ctg tcc tgg cgc aag ctc tac        240
Ser Leu Asn Glu His Ser Met Gln Ala Leu Ser Trp Arg Lys Leu Tyr           
65                  70                  75                  80            

ttg agc cgc gcc aag ctt aaa gcc tcc agc cgg acc tcg gct ctg ctc        288
Leu Ser Arg Ala Lys Leu Lys Ala Ser Ser Arg Thr Ser Ala Leu Leu           
                85                  90                  95                

tcc ggc ttc gcc atg gtg gca atg gtg gag gtg cag ctg gac gct gac        336
Ser Gly Phe Ala Met Val Ala Met Val Glu Val Gln Leu Asp Ala Asp           
            100                 105                 110                   

cac gac tac cca ccg ggg ctg ctc atc gcc ttc agt gcc tgc acc aca        384
His Asp Tyr Pro Pro Gly Leu Leu Ile Ala Phe Ser Ala Cys Thr Thr           
        115                 120                 125                       

gtg ctg gtg gct gtg cac ctg ttt gcg ctc atg atc agc acc tgc atc        432
Val Leu Val Ala Val His Leu Phe Ala Leu Met Ile Ser Thr Cys Ile           
    130                 135                 140                           

ctg ccc aac atc gag gcg gtg agc aac gtg cac aat ctc aac tcg gtc        480
Leu Pro Asn Ile Glu Ala Val Ser Asn Val His Asn Leu Asn Ser Val           
145                 150                 155                 160           

aag gag tcc ccc cat gag cgc atg cac cgc cac atc gag ctg gcc tgg        528
Lys Glu Ser Pro His Glu Arg Met His Arg His Ile Glu Leu Ala Trp           
                165                 170                 175               

gcc ttc tcc acc gtc atc ggc acg ctg ctc ttc cta gct gag gtg gtg        576
Ala Phe Ser Thr Val Ile Gly Thr Leu Leu Phe Leu Ala Glu Val Val           
            180                 185                 190                   

ctg ctc tgc tgg gtc aag ttc ttg ccc ctc aag agg caa gcg gga cag        624
Leu Leu Cys Trp Val Lys Phe Leu Pro Leu Lys Arg Gln Ala Gly Gln           
        195                 200                 205                       

cca agc ccc acc aag cct ccc gct gaa tca gtc atc gtc gcc aac gtc        672
Pro Ser Pro Thr Lys Pro Pro Ala Glu Ser Val Ile Val Ala Asn Val           
    210                 215                 220                           

agc acc agc agc ggc atc acc ccg ggc cag gca gct gcc atc gct tcg        720
Ser Thr Ser Ser Gly Ile Thr Pro Gly Gln Ala Ala Ala Ile Ala Ser           
225                 230                 235                 240           

acc acc atc atg gtg ccc ttc ggc ctg atc ttt atc gtc ttc gcc gtc        768
Thr Thr Ile Met Val Pro Phe Gly Leu Ile Phe Ile Val Phe Ala Val           
                245                 250                 255               

cac ttc tac cgc tca ctg gtt agc cat aag acc gac cga cag ttc cag        816
His Phe Tyr Arg Ser Leu Val Ser His Lys Thr Asp Arg Gln Phe Gln           
            260                 265                 270                   

gag ctc aac gag ctg gcg gag ttt gcc cgc tta cag gac cag ctg gac        864
Glu Leu Asn Glu Leu Ala Glu Phe Ala Arg Leu Gln Asp Gln Leu Asp           
        275                 280                 285                       

cac aga ggg gac cac ccc ctg acg ccc ggc agc cac tat gcc tag            909
His Arg Gly Asp His Pro Leu Thr Pro Gly Ser His Tyr Ala                   
    290                 295                 300                           


<210>  117
<211>  302
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  117

Met His Pro Glu Pro Ala Pro Pro Pro Ser Arg Ser Ser Pro Glu Leu 
1               5                   10                  15      


Pro Pro Ser Gly Gly Ser Thr Thr Ser Gly Ser Arg Arg Ser Arg Arg 
            20                  25                  30          


Arg Ser Gly Asp Gly Glu Pro Pro Gly Ala Pro Pro Pro Pro Pro Ser 
        35                  40                  45              


Ala Val Thr Tyr Pro Asp Trp Ile Gly Gln Ser Tyr Ser Glu Val Met 
    50                  55                  60                  


Ser Leu Asn Glu His Ser Met Gln Ala Leu Ser Trp Arg Lys Leu Tyr 
65                  70                  75                  80  


Leu Ser Arg Ala Lys Leu Lys Ala Ser Ser Arg Thr Ser Ala Leu Leu 
                85                  90                  95      


Ser Gly Phe Ala Met Val Ala Met Val Glu Val Gln Leu Asp Ala Asp 
            100                 105                 110         


His Asp Tyr Pro Pro Gly Leu Leu Ile Ala Phe Ser Ala Cys Thr Thr 
        115                 120                 125             


Val Leu Val Ala Val His Leu Phe Ala Leu Met Ile Ser Thr Cys Ile 
    130                 135                 140                 


Leu Pro Asn Ile Glu Ala Val Ser Asn Val His Asn Leu Asn Ser Val 
145                 150                 155                 160 


Lys Glu Ser Pro His Glu Arg Met His Arg His Ile Glu Leu Ala Trp 
                165                 170                 175     


Ala Phe Ser Thr Val Ile Gly Thr Leu Leu Phe Leu Ala Glu Val Val 
            180                 185                 190         


Leu Leu Cys Trp Val Lys Phe Leu Pro Leu Lys Arg Gln Ala Gly Gln 
        195                 200                 205             


Pro Ser Pro Thr Lys Pro Pro Ala Glu Ser Val Ile Val Ala Asn Val 
    210                 215                 220                 


Ser Thr Ser Ser Gly Ile Thr Pro Gly Gln Ala Ala Ala Ile Ala Ser 
225                 230                 235                 240 


Thr Thr Ile Met Val Pro Phe Gly Leu Ile Phe Ile Val Phe Ala Val 
                245                 250                 255     


His Phe Tyr Arg Ser Leu Val Ser His Lys Thr Asp Arg Gln Phe Gln 
            260                 265                 270         


Glu Leu Asn Glu Leu Ala Glu Phe Ala Arg Leu Gln Asp Gln Leu Asp 
        275                 280                 285             


His Arg Gly Asp His Pro Leu Thr Pro Gly Ser His Tyr Ala 
    290                 295                 300         


<210>  118
<211>  6
<212>  PRT
<213>  Mus musculus


<220>
<221>  MISC_FEATURE
<223>  223-228 of SEQ ID NO:72 (mORAI1)

<400>  118

Val Ala Asn His Ser Asp 
1               5       


<210>  119
<211>  6
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<223>  221 to 226 of SEQ ID NO:2 (hORAI1)

<400>  119

Ala Ala Asn Val Ser Thr 
1               5       


<210>  120
<211>  36
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Forward primer sequence

<400>  120
gcgccgccgc caacgtcagc accagcagcg gcatca                                 36


<210>  121
<211>  36
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Reverse primer sequence

<400>  121
tgatgccgct gctggtgctg acgttggcgg cggcgc                                 36


<210>  122
<211>  909
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  hORAI1/mORAI1 ECL2 (AANVST) sequence


<220>
<221>  CDS
<222>  (1)..(909)

<400>  122
atg cat ccg gag ccc gcc ccg ccc ccg agc cgc agc agt ccc gag ctt         48
Met His Pro Glu Pro Ala Pro Pro Pro Ser Arg Ser Ser Pro Glu Leu           
1               5                   10                  15                

ccc cca agc ggc ggc agc acc acc agc ggc agc cgc cgg agc cgc cgc         96
Pro Pro Ser Gly Gly Ser Thr Thr Ser Gly Ser Arg Arg Ser Arg Arg           
            20                  25                  30                    

cgc agc ggg gac ggg gag ccc ccg ggg gcc ccg cca ccg ccg ccg tcc        144
Arg Ser Gly Asp Gly Glu Pro Pro Gly Ala Pro Pro Pro Pro Pro Ser           
        35                  40                  45                        

gcc gtc acc tac ccg gac tgg atc ggc cag agt tac tcc gag gtg atg        192
Ala Val Thr Tyr Pro Asp Trp Ile Gly Gln Ser Tyr Ser Glu Val Met           
    50                  55                  60                            

agc ctc aac gag cac tcc atg cag gcg ctg tcc tgg cgc aag ctc tac        240
Ser Leu Asn Glu His Ser Met Gln Ala Leu Ser Trp Arg Lys Leu Tyr           
65                  70                  75                  80            

ttg agc cgc gcc aag ctt aaa gcc tcc agc cgg acc tcg gct ctg ctc        288
Leu Ser Arg Ala Lys Leu Lys Ala Ser Ser Arg Thr Ser Ala Leu Leu           
                85                  90                  95                

tcc ggc ttc gcc atg gtg gca atg gtg gag gtg cag ctg gac gct gac        336
Ser Gly Phe Ala Met Val Ala Met Val Glu Val Gln Leu Asp Ala Asp           
            100                 105                 110                   

cac gac tac cca ccg ggg ctg ctc atc gcc ttc agt gcc tgc acc aca        384
His Asp Tyr Pro Pro Gly Leu Leu Ile Ala Phe Ser Ala Cys Thr Thr           
        115                 120                 125                       

gtg ctg gtg gct gtg cac ctg ttt gcg ctc atg atc agc acc tgc atc        432
Val Leu Val Ala Val His Leu Phe Ala Leu Met Ile Ser Thr Cys Ile           
    130                 135                 140                           

ctg ccc aac atc gag gcg gtg agc aac gtg cac aat ctc aac tcg gtc        480
Leu Pro Asn Ile Glu Ala Val Ser Asn Val His Asn Leu Asn Ser Val           
145                 150                 155                 160           

aag gag tcc ccc cat gag cgc atg cac cgc cac atc gag ctg gcc tgg        528
Lys Glu Ser Pro His Glu Arg Met His Arg His Ile Glu Leu Ala Trp           
                165                 170                 175               

gcc ttc tcc acc gtc atc ggc acg ctg ctc ttc cta gct gag gtg gtg        576
Ala Phe Ser Thr Val Ile Gly Thr Leu Leu Phe Leu Ala Glu Val Val           
            180                 185                 190                   

ctg ctc tgc tgg gtc aag ttc ttg ccc ctc aag agg caa gcg gga cag        624
Leu Leu Cys Trp Val Lys Phe Leu Pro Leu Lys Arg Gln Ala Gly Gln           
        195                 200                 205                       

cca agc ccc acc aag cct ccc gct gaa tca gtc atc gcc gcc aac gtc        672
Pro Ser Pro Thr Lys Pro Pro Ala Glu Ser Val Ile Ala Ala Asn Val           
    210                 215                 220                           

agc acc agc agc ggc atc acc ccg ggc cag gca gct gcc atc gct tcg        720
Ser Thr Ser Ser Gly Ile Thr Pro Gly Gln Ala Ala Ala Ile Ala Ser           
225                 230                 235                 240           

acc acc atc atg gtg ccc ttc ggc ctg atc ttt atc gtc ttc gcc gtc        768
Thr Thr Ile Met Val Pro Phe Gly Leu Ile Phe Ile Val Phe Ala Val           
                245                 250                 255               

cac ttc tac cgc tca ctg gtt agc cat aag acc gac cga cag ttc cag        816
His Phe Tyr Arg Ser Leu Val Ser His Lys Thr Asp Arg Gln Phe Gln           
            260                 265                 270                   

gag ctc aac gag ctg gcg gag ttt gcc cgc tta cag gac cag ctg gac        864
Glu Leu Asn Glu Leu Ala Glu Phe Ala Arg Leu Gln Asp Gln Leu Asp           
        275                 280                 285                       

cac aga ggg gac cac ccc ctg acg ccc ggc agc cac tat gcc tag            909
His Arg Gly Asp His Pro Leu Thr Pro Gly Ser His Tyr Ala                   
    290                 295                 300                           


<210>  123
<211>  302
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  123

Met His Pro Glu Pro Ala Pro Pro Pro Ser Arg Ser Ser Pro Glu Leu 
1               5                   10                  15      


Pro Pro Ser Gly Gly Ser Thr Thr Ser Gly Ser Arg Arg Ser Arg Arg 
            20                  25                  30          


Arg Ser Gly Asp Gly Glu Pro Pro Gly Ala Pro Pro Pro Pro Pro Ser 
        35                  40                  45              


Ala Val Thr Tyr Pro Asp Trp Ile Gly Gln Ser Tyr Ser Glu Val Met 
    50                  55                  60                  


Ser Leu Asn Glu His Ser Met Gln Ala Leu Ser Trp Arg Lys Leu Tyr 
65                  70                  75                  80  


Leu Ser Arg Ala Lys Leu Lys Ala Ser Ser Arg Thr Ser Ala Leu Leu 
                85                  90                  95      


Ser Gly Phe Ala Met Val Ala Met Val Glu Val Gln Leu Asp Ala Asp 
            100                 105                 110         


His Asp Tyr Pro Pro Gly Leu Leu Ile Ala Phe Ser Ala Cys Thr Thr 
        115                 120                 125             


Val Leu Val Ala Val His Leu Phe Ala Leu Met Ile Ser Thr Cys Ile 
    130                 135                 140                 


Leu Pro Asn Ile Glu Ala Val Ser Asn Val His Asn Leu Asn Ser Val 
145                 150                 155                 160 


Lys Glu Ser Pro His Glu Arg Met His Arg His Ile Glu Leu Ala Trp 
                165                 170                 175     


Ala Phe Ser Thr Val Ile Gly Thr Leu Leu Phe Leu Ala Glu Val Val 
            180                 185                 190         


Leu Leu Cys Trp Val Lys Phe Leu Pro Leu Lys Arg Gln Ala Gly Gln 
        195                 200                 205             


Pro Ser Pro Thr Lys Pro Pro Ala Glu Ser Val Ile Ala Ala Asn Val 
    210                 215                 220                 


Ser Thr Ser Ser Gly Ile Thr Pro Gly Gln Ala Ala Ala Ile Ala Ser 
225                 230                 235                 240 


Thr Thr Ile Met Val Pro Phe Gly Leu Ile Phe Ile Val Phe Ala Val 
                245                 250                 255     


His Phe Tyr Arg Ser Leu Val Ser His Lys Thr Asp Arg Gln Phe Gln 
            260                 265                 270         


Glu Leu Asn Glu Leu Ala Glu Phe Ala Arg Leu Gln Asp Gln Leu Asp 
        275                 280                 285             


His Arg Gly Asp His Pro Leu Thr Pro Gly Ser His Tyr Ala 
    290                 295                 300         


<210>  124
<211>  8
<212>  PRT
<213>  Mus musculus


<220>
<221>  MISC_FEATURE
<223>  212 to 219 of SEQ ID NO:72 (mORAI1)

<400>  124

Ser Pro Thr Lys Pro Pro Ala Glu 
1               5               


<210>  125
<211>  8
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<223>  210 to 217 of SEQ ID NO:2 (hORAI1)

<400>  125

Arg Pro Thr Ser Lys Pro Pro Ala 
1               5               


<210>  126
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Forward primer sequence

<400>  126
gggacagcca aggcccacca gcaag                                             25


<210>  127
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Reverse primer sequence


<220>
<221>  misc_feature
<223>  Reverse primer sequence

<400>  127
cttgctggtg ggccttggct gtccc                                             25


<210>  128
<211>  909
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  hORAI1/mORAI1 ECL2 (RPTSKPPA) sequence


<220>
<221>  CDS
<222>  (1)..(909)

<400>  128
atg cat ccg gag ccc gcc ccg ccc ccg agc cgc agc agt ccc gag ctt         48
Met His Pro Glu Pro Ala Pro Pro Pro Ser Arg Ser Ser Pro Glu Leu           
1               5                   10                  15                

ccc cca agc ggc ggc agc acc acc agc ggc agc cgc cgg agc cgc cgc         96
Pro Pro Ser Gly Gly Ser Thr Thr Ser Gly Ser Arg Arg Ser Arg Arg           
            20                  25                  30                    

cgc agc ggg gac ggg gag ccc ccg ggg gcc ccg cca ccg ccg ccg tcc        144
Arg Ser Gly Asp Gly Glu Pro Pro Gly Ala Pro Pro Pro Pro Pro Ser           
        35                  40                  45                        

gcc gtc acc tac ccg gac tgg atc ggc cag agt tac tcc gag gtg atg        192
Ala Val Thr Tyr Pro Asp Trp Ile Gly Gln Ser Tyr Ser Glu Val Met           
    50                  55                  60                            

agc ctc aac gag cac tcc atg cag gcg ctg tcc tgg cgc aag ctc tac        240
Ser Leu Asn Glu His Ser Met Gln Ala Leu Ser Trp Arg Lys Leu Tyr           
65                  70                  75                  80            

ttg agc cgc gcc aag ctt aaa gcc tcc agc cgg acc tcg gct ctg ctc        288
Leu Ser Arg Ala Lys Leu Lys Ala Ser Ser Arg Thr Ser Ala Leu Leu           
                85                  90                  95                

tcc ggc ttc gcc atg gtg gca atg gtg gag gtg cag ctg gac gct gac        336
Ser Gly Phe Ala Met Val Ala Met Val Glu Val Gln Leu Asp Ala Asp           
            100                 105                 110                   

cac gac tac cca ccg ggg ctg ctc atc gcc ttc agt gcc tgc acc aca        384
His Asp Tyr Pro Pro Gly Leu Leu Ile Ala Phe Ser Ala Cys Thr Thr           
        115                 120                 125                       

gtg ctg gtg gct gtg cac ctg ttt gcg ctc atg atc agc acc tgc atc        432
Val Leu Val Ala Val His Leu Phe Ala Leu Met Ile Ser Thr Cys Ile           
    130                 135                 140                           

ctg ccc aac atc gag gcg gtg agc aac gtg cac aat ctc aac tcg gtc        480
Leu Pro Asn Ile Glu Ala Val Ser Asn Val His Asn Leu Asn Ser Val           
145                 150                 155                 160           

aag gag tcc ccc cat gag cgc atg cac cgc cac atc gag ctg gcc tgg        528
Lys Glu Ser Pro His Glu Arg Met His Arg His Ile Glu Leu Ala Trp           
                165                 170                 175               

gcc ttc tcc acc gtc atc ggc acg ctg ctc ttc cta gct gag gtg gtg        576
Ala Phe Ser Thr Val Ile Gly Thr Leu Leu Phe Leu Ala Glu Val Val           
            180                 185                 190                   

ctg ctc tgc tgg gtc aag ttc ttg ccc ctc aag agg caa gcg gga cag        624
Leu Leu Cys Trp Val Lys Phe Leu Pro Leu Lys Arg Gln Ala Gly Gln           
        195                 200                 205                       

cca agg ccc acc agc aag ccc cct gca tca gtc atc gtc gcc aac cac        672
Pro Arg Pro Thr Ser Lys Pro Pro Ala Ser Val Ile Val Ala Asn His           
    210                 215                 220                           

agc gac agc agc ggc atc acc ccg ggc cag gca gct gcc atc gct tcg        720
Ser Asp Ser Ser Gly Ile Thr Pro Gly Gln Ala Ala Ala Ile Ala Ser           
225                 230                 235                 240           

acc acc atc atg gtg ccc ttc ggc ctg atc ttt atc gtc ttc gcc gtc        768
Thr Thr Ile Met Val Pro Phe Gly Leu Ile Phe Ile Val Phe Ala Val           
                245                 250                 255               

cac ttc tac cgc tca ctg gtt agc cat aag acc gac cga cag ttc cag        816
His Phe Tyr Arg Ser Leu Val Ser His Lys Thr Asp Arg Gln Phe Gln           
            260                 265                 270                   

gag ctc aac gag ctg gcg gag ttt gcc cgc tta cag gac cag ctg gac        864
Glu Leu Asn Glu Leu Ala Glu Phe Ala Arg Leu Gln Asp Gln Leu Asp           
        275                 280                 285                       

cac aga ggg gac cac ccc ctg acg ccc ggc agc cac tat gcc tag            909
His Arg Gly Asp His Pro Leu Thr Pro Gly Ser His Tyr Ala                   
    290                 295                 300                           


<210>  129
<211>  302
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  129

Met His Pro Glu Pro Ala Pro Pro Pro Ser Arg Ser Ser Pro Glu Leu 
1               5                   10                  15      


Pro Pro Ser Gly Gly Ser Thr Thr Ser Gly Ser Arg Arg Ser Arg Arg 
            20                  25                  30          


Arg Ser Gly Asp Gly Glu Pro Pro Gly Ala Pro Pro Pro Pro Pro Ser 
        35                  40                  45              


Ala Val Thr Tyr Pro Asp Trp Ile Gly Gln Ser Tyr Ser Glu Val Met 
    50                  55                  60                  


Ser Leu Asn Glu His Ser Met Gln Ala Leu Ser Trp Arg Lys Leu Tyr 
65                  70                  75                  80  


Leu Ser Arg Ala Lys Leu Lys Ala Ser Ser Arg Thr Ser Ala Leu Leu 
                85                  90                  95      


Ser Gly Phe Ala Met Val Ala Met Val Glu Val Gln Leu Asp Ala Asp 
            100                 105                 110         


His Asp Tyr Pro Pro Gly Leu Leu Ile Ala Phe Ser Ala Cys Thr Thr 
        115                 120                 125             


Val Leu Val Ala Val His Leu Phe Ala Leu Met Ile Ser Thr Cys Ile 
    130                 135                 140                 


Leu Pro Asn Ile Glu Ala Val Ser Asn Val His Asn Leu Asn Ser Val 
145                 150                 155                 160 


Lys Glu Ser Pro His Glu Arg Met His Arg His Ile Glu Leu Ala Trp 
                165                 170                 175     


Ala Phe Ser Thr Val Ile Gly Thr Leu Leu Phe Leu Ala Glu Val Val 
            180                 185                 190         


Leu Leu Cys Trp Val Lys Phe Leu Pro Leu Lys Arg Gln Ala Gly Gln 
        195                 200                 205             


Pro Arg Pro Thr Ser Lys Pro Pro Ala Ser Val Ile Val Ala Asn His 
    210                 215                 220                 


Ser Asp Ser Ser Gly Ile Thr Pro Gly Gln Ala Ala Ala Ile Ala Ser 
225                 230                 235                 240 


Thr Thr Ile Met Val Pro Phe Gly Leu Ile Phe Ile Val Phe Ala Val 
                245                 250                 255     


His Phe Tyr Arg Ser Leu Val Ser His Lys Thr Asp Arg Gln Phe Gln 
            260                 265                 270         


Glu Leu Asn Glu Leu Ala Glu Phe Ala Arg Leu Gln Asp Gln Leu Asp 
        275                 280                 285             


His Arg Gly Asp His Pro Leu Thr Pro Gly Ser His Tyr Ala 
    290                 295                 300         


<210>  130
<211>  44
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Forward primer sequence

<400>  130
cagccaaggc ccaccaagcc gcccgccgag agtggcgcag cagc                        44


<210>  131
<211>  44
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Reverse primer sequence

<400>  131
gctgctgcgc cactctcggc gggcggcttg gtgggccttg gctg                        44


<210>  132
<211>  912
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  mORAI1/hORAI1 ECL2 (KPPAE) seqeunce


<220>
<221>  CDS
<222>  (1)..(912)

<400>  132
atg cat ccg gag cct gcc ccg ccc ccg agt cac agc aat ccg gag ctt         48
Met His Pro Glu Pro Ala Pro Pro Pro Ser His Ser Asn Pro Glu Leu           
1               5                   10                  15                

ccc gtg agc ggc ggc agc agc act agc ggc agc cgc cgg agc cgc cgc         96
Pro Val Ser Gly Gly Ser Ser Thr Ser Gly Ser Arg Arg Ser Arg Arg           
            20                  25                  30                    

cgc agc ggg gac ggg gag ccc tcg ggg gcc cca ccg ctg ccg ccg ccg        144
Arg Ser Gly Asp Gly Glu Pro Ser Gly Ala Pro Pro Leu Pro Pro Pro           
        35                  40                  45                        

cca ccc gcc gtc agc tac ccg gac tgg atc ggc cag agt tac tcc gag        192
Pro Pro Ala Val Ser Tyr Pro Asp Trp Ile Gly Gln Ser Tyr Ser Glu           
    50                  55                  60                            

gtg atg agc ctc aac gag cac tcg atg cag gcg ctg tcc tgg cgc aag        240
Val Met Ser Leu Asn Glu His Ser Met Gln Ala Leu Ser Trp Arg Lys           
65                  70                  75                  80            

ctc tac tta agc cgc gcc aag ctc aaa gct tcc agc cgg acc tcg gct        288
Leu Tyr Leu Ser Arg Ala Lys Leu Lys Ala Ser Ser Arg Thr Ser Ala           
                85                  90                  95                

ctg ctc tcc ggc ttc gcc atg gta gcg atg gtg gaa gtc cag ctg gac        336
Leu Leu Ser Gly Phe Ala Met Val Ala Met Val Glu Val Gln Leu Asp           
            100                 105                 110                   

aca gac cat gac tac cca cca ggg ttg ctc atc gtc ttt agt gcc tgc        384
Thr Asp His Asp Tyr Pro Pro Gly Leu Leu Ile Val Phe Ser Ala Cys           
        115                 120                 125                       

acc aca gtg cta gtg gcc gtg cac ctg ttt gcc ctc atg atc agc acc        432
Thr Thr Val Leu Val Ala Val His Leu Phe Ala Leu Met Ile Ser Thr           
    130                 135                 140                           

tgc atc ctg ccc aac atc gag gct gtg agc aac gtc cac aac ctc aac        480
Cys Ile Leu Pro Asn Ile Glu Ala Val Ser Asn Val His Asn Leu Asn           
145                 150                 155                 160           

tcg gtc aaa gag tca ccc cac gag cgc atg cat cgc cac atc gag ctg        528
Ser Val Lys Glu Ser Pro His Glu Arg Met His Arg His Ile Glu Leu           
                165                 170                 175               

gcc tgg gcc ttc tcc acg gtc atc ggg acg ctg ctt ttc cta gca gag        576
Ala Trp Ala Phe Ser Thr Val Ile Gly Thr Leu Leu Phe Leu Ala Glu           
            180                 185                 190                   

gtc gtg ctg ctc tgc tgg gtc aag ttc tta cct ctc aag aag cag cca        624
Val Val Leu Leu Cys Trp Val Lys Phe Leu Pro Leu Lys Lys Gln Pro           
        195                 200                 205                       

ggc cag cca agg ccc acc aag ccg ccc gcc gag agt ggc gca gca gcc        672
Gly Gln Pro Arg Pro Thr Lys Pro Pro Ala Glu Ser Gly Ala Ala Ala           
    210                 215                 220                           

aac gtc agc acc agc ggc atc acc ccg ggt gag gcg gca gcc att gcc        720
Asn Val Ser Thr Ser Gly Ile Thr Pro Gly Glu Ala Ala Ala Ile Ala           
225                 230                 235                 240           

tcc acc gcc atc atg gtt ccc tgt ggc ctg gtt ttc atc gtc ttt gct        768
Ser Thr Ala Ile Met Val Pro Cys Gly Leu Val Phe Ile Val Phe Ala           
                245                 250                 255               

gtt cac ttc tac cgc tcc ctg gtc agc cat aag acg gac cgg cag ttc        816
Val His Phe Tyr Arg Ser Leu Val Ser His Lys Thr Asp Arg Gln Phe           
            260                 265                 270                   

cag gag ctc aat gag ctg gcc gag ttt gcc cgc ttg cag gac cag ctg        864
Gln Glu Leu Asn Glu Leu Ala Glu Phe Ala Arg Leu Gln Asp Gln Leu           
        275                 280                 285                       

gac cac aga ggg gac cat tct cta aca ccg ggc acc cac tat gcc taa        912
Asp His Arg Gly Asp His Ser Leu Thr Pro Gly Thr His Tyr Ala               
    290                 295                 300                           


<210>  133
<211>  303
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  133

Met His Pro Glu Pro Ala Pro Pro Pro Ser His Ser Asn Pro Glu Leu 
1               5                   10                  15      


Pro Val Ser Gly Gly Ser Ser Thr Ser Gly Ser Arg Arg Ser Arg Arg 
            20                  25                  30          


Arg Ser Gly Asp Gly Glu Pro Ser Gly Ala Pro Pro Leu Pro Pro Pro 
        35                  40                  45              


Pro Pro Ala Val Ser Tyr Pro Asp Trp Ile Gly Gln Ser Tyr Ser Glu 
    50                  55                  60                  


Val Met Ser Leu Asn Glu His Ser Met Gln Ala Leu Ser Trp Arg Lys 
65                  70                  75                  80  


Leu Tyr Leu Ser Arg Ala Lys Leu Lys Ala Ser Ser Arg Thr Ser Ala 
                85                  90                  95      


Leu Leu Ser Gly Phe Ala Met Val Ala Met Val Glu Val Gln Leu Asp 
            100                 105                 110         


Thr Asp His Asp Tyr Pro Pro Gly Leu Leu Ile Val Phe Ser Ala Cys 
        115                 120                 125             


Thr Thr Val Leu Val Ala Val His Leu Phe Ala Leu Met Ile Ser Thr 
    130                 135                 140                 


Cys Ile Leu Pro Asn Ile Glu Ala Val Ser Asn Val His Asn Leu Asn 
145                 150                 155                 160 


Ser Val Lys Glu Ser Pro His Glu Arg Met His Arg His Ile Glu Leu 
                165                 170                 175     


Ala Trp Ala Phe Ser Thr Val Ile Gly Thr Leu Leu Phe Leu Ala Glu 
            180                 185                 190         


Val Val Leu Leu Cys Trp Val Lys Phe Leu Pro Leu Lys Lys Gln Pro 
        195                 200                 205             


Gly Gln Pro Arg Pro Thr Lys Pro Pro Ala Glu Ser Gly Ala Ala Ala 
    210                 215                 220                 


Asn Val Ser Thr Ser Gly Ile Thr Pro Gly Glu Ala Ala Ala Ile Ala 
225                 230                 235                 240 


Ser Thr Ala Ile Met Val Pro Cys Gly Leu Val Phe Ile Val Phe Ala 
                245                 250                 255     


Val His Phe Tyr Arg Ser Leu Val Ser His Lys Thr Asp Arg Gln Phe 
            260                 265                 270         


Gln Glu Leu Asn Glu Leu Ala Glu Phe Ala Arg Leu Gln Asp Gln Leu 
        275                 280                 285             


Asp His Arg Gly Asp His Ser Leu Thr Pro Gly Thr His Tyr Ala 
    290                 295                 300             


<210>  134
<211>  39
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Forward primer sequence

<400>  134
aagccccccg ccagtgtcat agtagccaac gtcagcacc                              39


<210>  135
<211>  39
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Reverse primer sequence

<400>  135
ggtgctgacg ttggctacta tgacactggc ggggggctt                              39


<210>  136
<211>  912
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  mORAI1/hORAI1 ECL2 (VIV) sequence


<220>
<221>  CDS
<222>  (1)..(912)

<400>  136
atg cat ccg gag cct gcc ccg ccc ccg agt cac agc aat ccg gag ctt         48
Met His Pro Glu Pro Ala Pro Pro Pro Ser His Ser Asn Pro Glu Leu           
1               5                   10                  15                

ccc gtg agc ggc ggc agc agc act agc ggc agc cgc cgg agc cgc cgc         96
Pro Val Ser Gly Gly Ser Ser Thr Ser Gly Ser Arg Arg Ser Arg Arg           
            20                  25                  30                    

cgc agc ggg gac ggg gag ccc tcg ggg gcc cca ccg ctg ccg ccg ccg        144
Arg Ser Gly Asp Gly Glu Pro Ser Gly Ala Pro Pro Leu Pro Pro Pro           
        35                  40                  45                        

cca ccc gcc gtc agc tac ccg gac tgg atc ggc cag agt tac tcc gag        192
Pro Pro Ala Val Ser Tyr Pro Asp Trp Ile Gly Gln Ser Tyr Ser Glu           
    50                  55                  60                            

gtg atg agc ctc aac gag cac tcg atg cag gcg ctg tcc tgg cgc aag        240
Val Met Ser Leu Asn Glu His Ser Met Gln Ala Leu Ser Trp Arg Lys           
65                  70                  75                  80            

ctc tac tta agc cgc gcc aag ctc aaa gct tcc agc cgg acc tcg gct        288
Leu Tyr Leu Ser Arg Ala Lys Leu Lys Ala Ser Ser Arg Thr Ser Ala           
                85                  90                  95                

ctg ctc tcc ggc ttc gcc atg gta gcg atg gtg gaa gtc cag ctg gac        336
Leu Leu Ser Gly Phe Ala Met Val Ala Met Val Glu Val Gln Leu Asp           
            100                 105                 110                   

aca gac cat gac tac cca cca ggg ttg ctc atc gtc ttt agt gcc tgc        384
Thr Asp His Asp Tyr Pro Pro Gly Leu Leu Ile Val Phe Ser Ala Cys           
        115                 120                 125                       

acc aca gtg cta gtg gcc gtg cac ctg ttt gcc ctc atg atc agc acc        432
Thr Thr Val Leu Val Ala Val His Leu Phe Ala Leu Met Ile Ser Thr           
    130                 135                 140                           

tgc atc ctg ccc aac atc gag gct gtg agc aac gtc cac aac ctc aac        480
Cys Ile Leu Pro Asn Ile Glu Ala Val Ser Asn Val His Asn Leu Asn           
145                 150                 155                 160           

tcg gtc aaa gag tca ccc cac gag cgc atg cat cgc cac atc gag ctg        528
Ser Val Lys Glu Ser Pro His Glu Arg Met His Arg His Ile Glu Leu           
                165                 170                 175               

gcc tgg gcc ttc tcc acg gtc atc ggg acg ctg ctt ttc cta gca gag        576
Ala Trp Ala Phe Ser Thr Val Ile Gly Thr Leu Leu Phe Leu Ala Glu           
            180                 185                 190                   

gtc gtg ctg ctc tgc tgg gtc aag ttc tta cct ctc aag aag cag cca        624
Val Val Leu Leu Cys Trp Val Lys Phe Leu Pro Leu Lys Lys Gln Pro           
        195                 200                 205                       

ggc cag cca agg ccc acc agc aag ccc ccc gcc agt gtc ata gta gcc        672
Gly Gln Pro Arg Pro Thr Ser Lys Pro Pro Ala Ser Val Ile Val Ala           
    210                 215                 220                           

aac gtc agc acc agc ggc atc acc ccg ggt gag gcg gca gcc att gcc        720
Asn Val Ser Thr Ser Gly Ile Thr Pro Gly Glu Ala Ala Ala Ile Ala           
225                 230                 235                 240           

tcc acc gcc atc atg gtt ccc tgt ggc ctg gtt ttc atc gtc ttt gct        768
Ser Thr Ala Ile Met Val Pro Cys Gly Leu Val Phe Ile Val Phe Ala           
                245                 250                 255               

gtt cac ttc tac cgc tcc ctg gtc agc cat aag acg gac cgg cag ttc        816
Val His Phe Tyr Arg Ser Leu Val Ser His Lys Thr Asp Arg Gln Phe           
            260                 265                 270                   

cag gag ctc aat gag ctg gcc gag ttt gcc cgc ttg cag gac cag ctg        864
Gln Glu Leu Asn Glu Leu Ala Glu Phe Ala Arg Leu Gln Asp Gln Leu           
        275                 280                 285                       

gac cac aga ggg gac cat tct cta aca ccg ggc acc cac tat gcc taa        912
Asp His Arg Gly Asp His Ser Leu Thr Pro Gly Thr His Tyr Ala               
    290                 295                 300                           


<210>  137
<211>  303
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  137

Met His Pro Glu Pro Ala Pro Pro Pro Ser His Ser Asn Pro Glu Leu 
1               5                   10                  15      


Pro Val Ser Gly Gly Ser Ser Thr Ser Gly Ser Arg Arg Ser Arg Arg 
            20                  25                  30          


Arg Ser Gly Asp Gly Glu Pro Ser Gly Ala Pro Pro Leu Pro Pro Pro 
        35                  40                  45              


Pro Pro Ala Val Ser Tyr Pro Asp Trp Ile Gly Gln Ser Tyr Ser Glu 
    50                  55                  60                  


Val Met Ser Leu Asn Glu His Ser Met Gln Ala Leu Ser Trp Arg Lys 
65                  70                  75                  80  


Leu Tyr Leu Ser Arg Ala Lys Leu Lys Ala Ser Ser Arg Thr Ser Ala 
                85                  90                  95      


Leu Leu Ser Gly Phe Ala Met Val Ala Met Val Glu Val Gln Leu Asp 
            100                 105                 110         


Thr Asp His Asp Tyr Pro Pro Gly Leu Leu Ile Val Phe Ser Ala Cys 
        115                 120                 125             


Thr Thr Val Leu Val Ala Val His Leu Phe Ala Leu Met Ile Ser Thr 
    130                 135                 140                 


Cys Ile Leu Pro Asn Ile Glu Ala Val Ser Asn Val His Asn Leu Asn 
145                 150                 155                 160 


Ser Val Lys Glu Ser Pro His Glu Arg Met His Arg His Ile Glu Leu 
                165                 170                 175     


Ala Trp Ala Phe Ser Thr Val Ile Gly Thr Leu Leu Phe Leu Ala Glu 
            180                 185                 190         


Val Val Leu Leu Cys Trp Val Lys Phe Leu Pro Leu Lys Lys Gln Pro 
        195                 200                 205             


Gly Gln Pro Arg Pro Thr Ser Lys Pro Pro Ala Ser Val Ile Val Ala 
    210                 215                 220                 


Asn Val Ser Thr Ser Gly Ile Thr Pro Gly Glu Ala Ala Ala Ile Ala 
225                 230                 235                 240 


Ser Thr Ala Ile Met Val Pro Cys Gly Leu Val Phe Ile Val Phe Ala 
                245                 250                 255     


Val His Phe Tyr Arg Ser Leu Val Ser His Lys Thr Asp Arg Gln Phe 
            260                 265                 270         


Gln Glu Leu Asn Glu Leu Ala Glu Phe Ala Arg Leu Gln Asp Gln Leu 
        275                 280                 285             


Asp His Arg Gly Asp His Ser Leu Thr Pro Gly Thr His Tyr Ala 
    290                 295                 300             


<210>  138
<211>  49
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Forward primer sequence

<400>  138
gcccaccagc aagcccgccg agagtgtcat agtagccaac gtcagcacc                   49


<210>  139
<211>  49
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Reverse primer sequence

<400>  139
ggtgctgacg ttggctacta tgacactctc ggcgggcttg ctggtgggc                   49


<210>  140
<211>  912
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  mORAI1/hORAI1 ECL2 (AESVIV) sequence


<220>
<221>  CDS
<222>  (1)..(912)

<400>  140
atg cat ccg gag cct gcc ccg ccc ccg agt cac agc aat ccg gag ctt         48
Met His Pro Glu Pro Ala Pro Pro Pro Ser His Ser Asn Pro Glu Leu           
1               5                   10                  15                

ccc gtg agc ggc ggc agc agc act agc ggc agc cgc cgg agc cgc cgc         96
Pro Val Ser Gly Gly Ser Ser Thr Ser Gly Ser Arg Arg Ser Arg Arg           
            20                  25                  30                    

cgc agc ggg gac ggg gag ccc tcg ggg gcc cca ccg ctg ccg ccg ccg        144
Arg Ser Gly Asp Gly Glu Pro Ser Gly Ala Pro Pro Leu Pro Pro Pro           
        35                  40                  45                        

cca ccc gcc gtc agc tac ccg gac tgg atc ggc cag agt tac tcc gag        192
Pro Pro Ala Val Ser Tyr Pro Asp Trp Ile Gly Gln Ser Tyr Ser Glu           
    50                  55                  60                            

gtg atg agc ctc aac gag cac tcg atg cag gcg ctg tcc tgg cgc aag        240
Val Met Ser Leu Asn Glu His Ser Met Gln Ala Leu Ser Trp Arg Lys           
65                  70                  75                  80            

ctc tac tta agc cgc gcc aag ctc aaa gct tcc agc cgg acc tcg gct        288
Leu Tyr Leu Ser Arg Ala Lys Leu Lys Ala Ser Ser Arg Thr Ser Ala           
                85                  90                  95                

ctg ctc tcc ggc ttc gcc atg gta gcg atg gtg gaa gtc cag ctg gac        336
Leu Leu Ser Gly Phe Ala Met Val Ala Met Val Glu Val Gln Leu Asp           
            100                 105                 110                   

aca gac cat gac tac cca cca ggg ttg ctc atc gtc ttt agt gcc tgc        384
Thr Asp His Asp Tyr Pro Pro Gly Leu Leu Ile Val Phe Ser Ala Cys           
        115                 120                 125                       

acc aca gtg cta gtg gcc gtg cac ctg ttt gcc ctc atg atc agc acc        432
Thr Thr Val Leu Val Ala Val His Leu Phe Ala Leu Met Ile Ser Thr           
    130                 135                 140                           

tgc atc ctg ccc aac atc gag gct gtg agc aac gtc cac aac ctc aac        480
Cys Ile Leu Pro Asn Ile Glu Ala Val Ser Asn Val His Asn Leu Asn           
145                 150                 155                 160           

tcg gtc aaa gag tca ccc cac gag cgc atg cat cgc cac atc gag ctg        528
Ser Val Lys Glu Ser Pro His Glu Arg Met His Arg His Ile Glu Leu           
                165                 170                 175               

gcc tgg gcc ttc tcc acg gtc atc ggg acg ctg ctt ttc cta gca gag        576
Ala Trp Ala Phe Ser Thr Val Ile Gly Thr Leu Leu Phe Leu Ala Glu           
            180                 185                 190                   

gtc gtg ctg ctc tgc tgg gtc aag ttc tta cct ctc aag aag cag cca        624
Val Val Leu Leu Cys Trp Val Lys Phe Leu Pro Leu Lys Lys Gln Pro           
        195                 200                 205                       

ggc cag cca agg ccc acc agc aag ccc gcc gag agt gtc ata gta gcc        672
Gly Gln Pro Arg Pro Thr Ser Lys Pro Ala Glu Ser Val Ile Val Ala           
    210                 215                 220                           

aac gtc agc acc agc ggc atc acc ccg ggt gag gcg gca gcc att gcc        720
Asn Val Ser Thr Ser Gly Ile Thr Pro Gly Glu Ala Ala Ala Ile Ala           
225                 230                 235                 240           

tcc acc gcc atc atg gtt ccc tgt ggc ctg gtt ttc atc gtc ttt gct        768
Ser Thr Ala Ile Met Val Pro Cys Gly Leu Val Phe Ile Val Phe Ala           
                245                 250                 255               

gtt cac ttc tac cgc tcc ctg gtc agc cat aag acg gac cgg cag ttc        816
Val His Phe Tyr Arg Ser Leu Val Ser His Lys Thr Asp Arg Gln Phe           
            260                 265                 270                   

cag gag ctc aat gag ctg gcc gag ttt gcc cgc ttg cag gac cag ctg        864
Gln Glu Leu Asn Glu Leu Ala Glu Phe Ala Arg Leu Gln Asp Gln Leu           
        275                 280                 285                       

gac cac aga ggg gac cat tct cta aca ccg ggc acc cac tat gcc taa        912
Asp His Arg Gly Asp His Ser Leu Thr Pro Gly Thr His Tyr Ala               
    290                 295                 300                           


<210>  141
<211>  303
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  141

Met His Pro Glu Pro Ala Pro Pro Pro Ser His Ser Asn Pro Glu Leu 
1               5                   10                  15      


Pro Val Ser Gly Gly Ser Ser Thr Ser Gly Ser Arg Arg Ser Arg Arg 
            20                  25                  30          


Arg Ser Gly Asp Gly Glu Pro Ser Gly Ala Pro Pro Leu Pro Pro Pro 
        35                  40                  45              


Pro Pro Ala Val Ser Tyr Pro Asp Trp Ile Gly Gln Ser Tyr Ser Glu 
    50                  55                  60                  


Val Met Ser Leu Asn Glu His Ser Met Gln Ala Leu Ser Trp Arg Lys 
65                  70                  75                  80  


Leu Tyr Leu Ser Arg Ala Lys Leu Lys Ala Ser Ser Arg Thr Ser Ala 
                85                  90                  95      


Leu Leu Ser Gly Phe Ala Met Val Ala Met Val Glu Val Gln Leu Asp 
            100                 105                 110         


Thr Asp His Asp Tyr Pro Pro Gly Leu Leu Ile Val Phe Ser Ala Cys 
        115                 120                 125             


Thr Thr Val Leu Val Ala Val His Leu Phe Ala Leu Met Ile Ser Thr 
    130                 135                 140                 


Cys Ile Leu Pro Asn Ile Glu Ala Val Ser Asn Val His Asn Leu Asn 
145                 150                 155                 160 


Ser Val Lys Glu Ser Pro His Glu Arg Met His Arg His Ile Glu Leu 
                165                 170                 175     


Ala Trp Ala Phe Ser Thr Val Ile Gly Thr Leu Leu Phe Leu Ala Glu 
            180                 185                 190         


Val Val Leu Leu Cys Trp Val Lys Phe Leu Pro Leu Lys Lys Gln Pro 
        195                 200                 205             


Gly Gln Pro Arg Pro Thr Ser Lys Pro Ala Glu Ser Val Ile Val Ala 
    210                 215                 220                 


Asn Val Ser Thr Ser Gly Ile Thr Pro Gly Glu Ala Ala Ala Ile Ala 
225                 230                 235                 240 


Ser Thr Ala Ile Met Val Pro Cys Gly Leu Val Phe Ile Val Phe Ala 
                245                 250                 255     


Val His Phe Tyr Arg Ser Leu Val Ser His Lys Thr Asp Arg Gln Phe 
            260                 265                 270         


Gln Glu Leu Asn Glu Leu Ala Glu Phe Ala Arg Leu Gln Asp Gln Leu 
        275                 280                 285             


Asp His Arg Gly Asp His Ser Leu Thr Pro Gly Thr His Tyr Ala 
    290                 295                 300             


<210>  142
<211>  38
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Forward primer sequence

<400>  142
ggcgcagcag ccaaccacag cgacagcggc atcacccc                               38


<210>  143
<211>  38
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Reverse primer sequence

<400>  143
ggggtgatgc cgctgtcgct gtggttggct gctgcgcc                               38


<210>  144
<211>  912
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  mORAI1/hORAI1 ECL2 (HSD) sequence


<220>
<221>  CDS
<222>  (1)..(912)

<400>  144
atg cat ccg gag cct gcc ccg ccc ccg agt cac agc aat ccg gag ctt         48
Met His Pro Glu Pro Ala Pro Pro Pro Ser His Ser Asn Pro Glu Leu           
1               5                   10                  15                

ccc gtg agc ggc ggc agc agc act agc ggc agc cgc cgg agc cgc cgc         96
Pro Val Ser Gly Gly Ser Ser Thr Ser Gly Ser Arg Arg Ser Arg Arg           
            20                  25                  30                    

cgc agc ggg gac ggg gag ccc tcg ggg gcc cca ccg ctg ccg ccg ccg        144
Arg Ser Gly Asp Gly Glu Pro Ser Gly Ala Pro Pro Leu Pro Pro Pro           
        35                  40                  45                        

cca ccc gcc gtc agc tac ccg gac tgg atc ggc cag agt tac tcc gag        192
Pro Pro Ala Val Ser Tyr Pro Asp Trp Ile Gly Gln Ser Tyr Ser Glu           
    50                  55                  60                            

gtg atg agc ctc aac gag cac tcg atg cag gcg ctg tcc tgg cgc aag        240
Val Met Ser Leu Asn Glu His Ser Met Gln Ala Leu Ser Trp Arg Lys           
65                  70                  75                  80            

ctc tac tta agc cgc gcc aag ctc aaa gct tcc agc cgg acc tcg gct        288
Leu Tyr Leu Ser Arg Ala Lys Leu Lys Ala Ser Ser Arg Thr Ser Ala           
                85                  90                  95                

ctg ctc tcc ggc ttc gcc atg gta gcg atg gtg gaa gtc cag ctg gac        336
Leu Leu Ser Gly Phe Ala Met Val Ala Met Val Glu Val Gln Leu Asp           
            100                 105                 110                   

aca gac cat gac tac cca cca ggg ttg ctc atc gtc ttt agt gcc tgc        384
Thr Asp His Asp Tyr Pro Pro Gly Leu Leu Ile Val Phe Ser Ala Cys           
        115                 120                 125                       

acc aca gtg cta gtg gcc gtg cac ctg ttt gcc ctc atg atc agc acc        432
Thr Thr Val Leu Val Ala Val His Leu Phe Ala Leu Met Ile Ser Thr           
    130                 135                 140                           

tgc atc ctg ccc aac atc gag gct gtg agc aac gtc cac aac ctc aac        480
Cys Ile Leu Pro Asn Ile Glu Ala Val Ser Asn Val His Asn Leu Asn           
145                 150                 155                 160           

tcg gtc aaa gag tca ccc cac gag cgc atg cat cgc cac atc gag ctg        528
Ser Val Lys Glu Ser Pro His Glu Arg Met His Arg His Ile Glu Leu           
                165                 170                 175               

gcc tgg gcc ttc tcc acg gtc atc ggg acg ctg ctt ttc cta gca gag        576
Ala Trp Ala Phe Ser Thr Val Ile Gly Thr Leu Leu Phe Leu Ala Glu           
            180                 185                 190                   

gtc gtg ctg ctc tgc tgg gtc aag ttc tta cct ctc aag aag cag cca        624
Val Val Leu Leu Cys Trp Val Lys Phe Leu Pro Leu Lys Lys Gln Pro           
        195                 200                 205                       

ggc cag cca agg ccc acc agc aag ccc ccc gcc agt ggc gca gca gcc        672
Gly Gln Pro Arg Pro Thr Ser Lys Pro Pro Ala Ser Gly Ala Ala Ala           
    210                 215                 220                           

aac cac agc gac agc ggc atc acc ccg ggt gag gcg gca gcc att gcc        720
Asn His Ser Asp Ser Gly Ile Thr Pro Gly Glu Ala Ala Ala Ile Ala           
225                 230                 235                 240           

tcc acc gcc atc atg gtt ccc tgt ggc ctg gtt ttc atc gtc ttt gct        768
Ser Thr Ala Ile Met Val Pro Cys Gly Leu Val Phe Ile Val Phe Ala           
                245                 250                 255               

gtt cac ttc tac cgc tcc ctg gtc agc cat aag acg gac cgg cag ttc        816
Val His Phe Tyr Arg Ser Leu Val Ser His Lys Thr Asp Arg Gln Phe           
            260                 265                 270                   

cag gag ctc aat gag ctg gcc gag ttt gcc cgc ttg cag gac cag ctg        864
Gln Glu Leu Asn Glu Leu Ala Glu Phe Ala Arg Leu Gln Asp Gln Leu           
        275                 280                 285                       

gac cac aga ggg gac cat tct cta aca ccg ggc acc cac tat gcc taa        912
Asp His Arg Gly Asp His Ser Leu Thr Pro Gly Thr His Tyr Ala               
    290                 295                 300                           


<210>  145
<211>  303
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  145

Met His Pro Glu Pro Ala Pro Pro Pro Ser His Ser Asn Pro Glu Leu 
1               5                   10                  15      


Pro Val Ser Gly Gly Ser Ser Thr Ser Gly Ser Arg Arg Ser Arg Arg 
            20                  25                  30          


Arg Ser Gly Asp Gly Glu Pro Ser Gly Ala Pro Pro Leu Pro Pro Pro 
        35                  40                  45              


Pro Pro Ala Val Ser Tyr Pro Asp Trp Ile Gly Gln Ser Tyr Ser Glu 
    50                  55                  60                  


Val Met Ser Leu Asn Glu His Ser Met Gln Ala Leu Ser Trp Arg Lys 
65                  70                  75                  80  


Leu Tyr Leu Ser Arg Ala Lys Leu Lys Ala Ser Ser Arg Thr Ser Ala 
                85                  90                  95      


Leu Leu Ser Gly Phe Ala Met Val Ala Met Val Glu Val Gln Leu Asp 
            100                 105                 110         


Thr Asp His Asp Tyr Pro Pro Gly Leu Leu Ile Val Phe Ser Ala Cys 
        115                 120                 125             


Thr Thr Val Leu Val Ala Val His Leu Phe Ala Leu Met Ile Ser Thr 
    130                 135                 140                 


Cys Ile Leu Pro Asn Ile Glu Ala Val Ser Asn Val His Asn Leu Asn 
145                 150                 155                 160 


Ser Val Lys Glu Ser Pro His Glu Arg Met His Arg His Ile Glu Leu 
                165                 170                 175     


Ala Trp Ala Phe Ser Thr Val Ile Gly Thr Leu Leu Phe Leu Ala Glu 
            180                 185                 190         


Val Val Leu Leu Cys Trp Val Lys Phe Leu Pro Leu Lys Lys Gln Pro 
        195                 200                 205             


Gly Gln Pro Arg Pro Thr Ser Lys Pro Pro Ala Ser Gly Ala Ala Ala 
    210                 215                 220                 


Asn His Ser Asp Ser Gly Ile Thr Pro Gly Glu Ala Ala Ala Ile Ala 
225                 230                 235                 240 


Ser Thr Ala Ile Met Val Pro Cys Gly Leu Val Phe Ile Val Phe Ala 
                245                 250                 255     


Val His Phe Tyr Arg Ser Leu Val Ser His Lys Thr Asp Arg Gln Phe 
            260                 265                 270         


Gln Glu Leu Asn Glu Leu Ala Glu Phe Ala Arg Leu Gln Asp Gln Leu 
        275                 280                 285             


Asp His Arg Gly Asp His Ser Leu Thr Pro Gly Thr His Tyr Ala 
    290                 295                 300             


<210>  146
<211>  25
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker sequence "L25"

<400>  146

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
1               5                   10                  15      


Gly Gly Gly Ser Gly Gly Gly Gly Ser 
            20                  25  


<210>  147
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker sequence "L20"

<400>  147

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
1               5                   10                  15      


Gly Gly Gly Ser 
            20  


<210>  148
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker sequence


<220>
<221>  MISC_FEATURE
<222>  (1)..(2)
<223>  X in position 1 and 2 are each independently any amino acid 
       residue

<220>
<221>  MISC_FEATURE
<222>  (4)..(5)
<223>  X in position 4 and 5 are each independently any amino acid 
       residue

<400>  148

Xaa Xaa Asn Xaa Xaa Gly 
1               5       


<210>  149
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker sequence

<400>  149

Gly Gly Gly Gly 
1               


<210>  150
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker sequence

<400>  150

Gly Gly Gly Gly Gly 
1               5   


<210>  151
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker sequence

<400>  151

Gly Gly Gly Gly Gly Gly Gly 
1               5           


<210>  152
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker sequence

<400>  152

Gly Gly Gly Gly Ser 
1               5   


<210>  153
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker sequence

<400>  153

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
1               5                   10  


<210>  154
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker sequence

<400>  154

Gly Gly Gly Gly Gly Lys 
1               5       


<210>  155
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker sequence

<400>  155

Gly Gly Gly Gly Gly Lys Arg 
1               5           


<210>  156
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker sequence

<400>  156

Gly Gly Gly Asn Gly Ser Gly Gly 
1               5               


<210>  157
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker sequence

<400>  157

Gly Gly Gly Cys Gly Gly Gly Gly 
1               5               


<210>  158
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker sequence

<400>  158

Gly Pro Asn Gly Gly 
1               5   


<210>  159
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker sequence

<400>  159

Gly Gly Gly Lys Gly Gly Gly Gly 
1               5               


<210>  160
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker sequence

<400>  160

Gly Gly Glu Gly Gly Gly 
1               5       


<210>  161
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker sequence

<400>  161

Gly Gly Glu Glu Glu Gly Gly Gly 
1               5               


<210>  162
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker sequence

<400>  162

Gly Glu Glu Glu Gly 
1               5   


<210>  163
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker sequence

<400>  163

Gly Glu Glu Glu 
1               


<210>  164
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker sequence

<400>  164

Gly Gly Asp Gly Gly Gly 
1               5       


<210>  165
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker sequence

<400>  165

Gly Gly Asp Asp Asp Gly Gly 
1               5           


<210>  166
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker sequence

<400>  166

Gly Asp Asp Asp Gly 
1               5   


<210>  167
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker sequence

<400>  167

Gly Asp Asp Asp 
1               


<210>  168
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker sequence

<400>  168

Gly Gly Gly Gly Ser Asp Asp Ser Asp Glu Gly Ser Asp Gly Glu Asp 
1               5                   10                  15      


Gly Gly Gly Gly Ser 
            20      


<210>  169
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker sequence

<400>  169

Trp Glu Trp Glu Trp 
1               5   


<210>  170
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker sequence

<400>  170

Phe Glu Phe Glu Phe 
1               5   


<210>  171
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker sequence

<400>  171

Glu Glu Glu Trp Trp Trp 
1               5       


<210>  172
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker sequence

<400>  172

Glu Glu Glu Phe Phe Phe 
1               5       


<210>  173
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker sequence

<400>  173

Trp Trp Glu Glu Glu Trp Trp 
1               5           


<210>  174
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker sequence

<400>  174

Phe Phe Glu Glu Glu Phe Phe 
1               5           


<210>  175
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker sequence


<220>
<221>  MISC_FEATURE
<222>  (1)..(2)
<223>  X in positions 1 and 2 are each independently any amino acid 
       residue

<220>
<221>  MISC_FEATURE
<222>  (4)..(5)
<223>  X in positions 4 and 5 are each independently any amino acid 
       residue

<400>  175

Xaa Xaa Tyr Xaa Xaa Gly 
1               5       


<210>  176
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker sequence


<220>
<221>  MISC_FEATURE
<222>  (1)..(2)
<223>  X in positions 1 and 2 are each independently any amino acid 
       residue

<220>
<221>  MISC_FEATURE
<222>  (4)..(5)
<223>  X in positions 4 And 5 are each independently any amino acid 
       residue

<400>  176

Xaa Xaa Ser Xaa Xaa Gly 
1               5       


<210>  177
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker sequence


<220>
<221>  MISC_FEATURE
<222>  (1)..(2)
<223>  X in positions 1 and 2 are each independently any amino acid 
       residue

<220>
<221>  MISC_FEATURE
<222>  (4)..(5)
<223>  X in positions 4 and 5 are each independently any amino acid 
       residue

<400>  177

Xaa Xaa Thr Xaa Xaa Gly 
1               5       


<210>  178
<211>  22
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker sequence

<400>  178

Gly Ser Gly Ser Ala Thr Gly Gly Ser Gly Ser Thr Ala Ser Ser Gly 
1               5                   10                  15      


Ser Gly Ser Ala Thr His 
            20          


<210>  179
<211>  22
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker sequence

<400>  179

His Gly Ser Gly Ser Ala Thr Gly Gly Ser Gly Ser Thr Ala Ser Ser 
1               5                   10                  15      


Gly Ser Gly Ser Ala Thr 
            20          


<210>  180
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker sequence

<400>  180

Ala Glu Ala Ala Ala Lys Glu Ala Ala Ala Lys Glu Ala Ala Ala Lys 
1               5                   10                  15      


Ala Gly Gly 
            


<210>  181
<211>  37
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Forward primer sequence

<400>  181
gctagctgaa ccaccatgga tgtatgcgtc cgtcttg                                37


<210>  182
<211>  52
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Forward primer sequence

<400>  182
gggactcctc ctgcaccagg gccagagcct cagccatagt cacagtgaga ag               52


<210>  183
<211>  70
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Forward primer sequence

<400>  183
cagccatagt cacagtgaga aggcgacagg aaccagctcg ggagccaaca tggtgagcaa       60

gggcgaggag                                                              70


<210>  184
<211>  44
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Reverse primer sequence

<400>  184
cggcatggac gagctgtaca agtctgagga gtcgactgca gcag                        44


<210>  185
<211>  27
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Forward primer sequence

<400>  185
ggagtcgact gcagcagagt tttgccg                                           27


<210>  186
<211>  33
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Reverse primer sequence

<400>  186
ctttaagaag cctcttaaga agtaggcggc cgc                                    33


<210>  187
<211>  39
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Forward primer sequence

<400>  187
aagccccctg catcaggcgc cgccgccaac cacagcgac                              39


<210>  188
<211>  39
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Reverse primer sequence

<400>  188
gtcgctgtgg ttggcggcgg cgcctgatgc agggggctt                              39


<210>  189
<211>  12
<212>  PRT
<213>  Mus musculus


<220>
<221>  MISC_FEATURE
<223>  212 to 223 of SEQ ID NO:72

<400>  189

Ser Pro Thr Lys Pro Pro Ala Glu Ser Val Ile Val 
1               5                   10          


<210>  190
<211>  12
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<223>  210 to 221 of SEQ ID NO:2

<400>  190

Arg Pro Thr Ser Lys Pro Pro Ala Ser Gly Ala Ala 
1               5                   10          


<210>  191
<211>  909
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  hORAI1/mORAI1 ECL2 (RPTSKPPASGAA) sequence


<220>
<221>  CDS
<222>  (1)..(909)

<400>  191
atg cat ccg gag ccc gcc ccg ccc ccg agc cgc agc agt ccc gag ctt         48
Met His Pro Glu Pro Ala Pro Pro Pro Ser Arg Ser Ser Pro Glu Leu           
1               5                   10                  15                

ccc cca agc ggc ggc agc acc acc agc ggc agc cgc cgg agc cgc cgc         96
Pro Pro Ser Gly Gly Ser Thr Thr Ser Gly Ser Arg Arg Ser Arg Arg           
            20                  25                  30                    

cgc agc ggg gac ggg gag ccc ccg ggg gcc ccg cca ccg ccg ccg tcc        144
Arg Ser Gly Asp Gly Glu Pro Pro Gly Ala Pro Pro Pro Pro Pro Ser           
        35                  40                  45                        

gcc gtc acc tac ccg gac tgg atc ggc cag agt tac tcc gag gtg atg        192
Ala Val Thr Tyr Pro Asp Trp Ile Gly Gln Ser Tyr Ser Glu Val Met           
    50                  55                  60                            

agc ctc aac gag cac tcc atg cag gcg ctg tcc tgg cgc aag ctc tac        240
Ser Leu Asn Glu His Ser Met Gln Ala Leu Ser Trp Arg Lys Leu Tyr           
65                  70                  75                  80            

ttg agc cgc gcc aag ctt aaa gcc tcc agc cgg acc tcg gct ctg ctc        288
Leu Ser Arg Ala Lys Leu Lys Ala Ser Ser Arg Thr Ser Ala Leu Leu           
                85                  90                  95                

tcc ggc ttc gcc atg gtg gca atg gtg gag gtg cag ctg gac gct gac        336
Ser Gly Phe Ala Met Val Ala Met Val Glu Val Gln Leu Asp Ala Asp           
            100                 105                 110                   

cac gac tac cca ccg ggg ctg ctc atc gcc ttc agt gcc tgc acc aca        384
His Asp Tyr Pro Pro Gly Leu Leu Ile Ala Phe Ser Ala Cys Thr Thr           
        115                 120                 125                       

gtg ctg gtg gct gtg cac ctg ttt gcg ctc atg atc agc acc tgc atc        432
Val Leu Val Ala Val His Leu Phe Ala Leu Met Ile Ser Thr Cys Ile           
    130                 135                 140                           

ctg ccc aac atc gag gcg gtg agc aac gtg cac aat ctc aac tcg gtc        480
Leu Pro Asn Ile Glu Ala Val Ser Asn Val His Asn Leu Asn Ser Val           
145                 150                 155                 160           

aag gag tcc ccc cat gag cgc atg cac cgc cac atc gag ctg gcc tgg        528
Lys Glu Ser Pro His Glu Arg Met His Arg His Ile Glu Leu Ala Trp           
                165                 170                 175               

gcc ttc tcc acc gtc atc ggc acg ctg ctc ttc cta gct gag gtg gtg        576
Ala Phe Ser Thr Val Ile Gly Thr Leu Leu Phe Leu Ala Glu Val Val           
            180                 185                 190                   

ctg ctc tgc tgg gtc aag ttc ttg ccc ctc aag agg caa gcg gga cag        624
Leu Leu Cys Trp Val Lys Phe Leu Pro Leu Lys Arg Gln Ala Gly Gln           
        195                 200                 205                       

cca agg ccc acc agc aag ccc cct gca tca ggc gcc gcc gcc aac cac        672
Pro Arg Pro Thr Ser Lys Pro Pro Ala Ser Gly Ala Ala Ala Asn His           
    210                 215                 220                           

agc gac agc agc ggc atc acc ccg ggc cag gca gct gcc atc gct tcg        720
Ser Asp Ser Ser Gly Ile Thr Pro Gly Gln Ala Ala Ala Ile Ala Ser           
225                 230                 235                 240           

acc acc atc atg gtg ccc ttc ggc ctg atc ttt atc gtc ttc gcc gtc        768
Thr Thr Ile Met Val Pro Phe Gly Leu Ile Phe Ile Val Phe Ala Val           
                245                 250                 255               

cac ttc tac cgc tca ctg gtt agc cat aag acc gac cga cag ttc cag        816
His Phe Tyr Arg Ser Leu Val Ser His Lys Thr Asp Arg Gln Phe Gln           
            260                 265                 270                   

gag ctc aac gag ctg gcg gag ttt gcc cgc tta cag gac cag ctg gac        864
Glu Leu Asn Glu Leu Ala Glu Phe Ala Arg Leu Gln Asp Gln Leu Asp           
        275                 280                 285                       

cac aga ggg gac cac ccc ctg acg ccc ggc agc cac tat gcc tag            909
His Arg Gly Asp His Pro Leu Thr Pro Gly Ser His Tyr Ala                   
    290                 295                 300                           


<210>  192
<211>  302
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  192

Met His Pro Glu Pro Ala Pro Pro Pro Ser Arg Ser Ser Pro Glu Leu 
1               5                   10                  15      


Pro Pro Ser Gly Gly Ser Thr Thr Ser Gly Ser Arg Arg Ser Arg Arg 
            20                  25                  30          


Arg Ser Gly Asp Gly Glu Pro Pro Gly Ala Pro Pro Pro Pro Pro Ser 
        35                  40                  45              


Ala Val Thr Tyr Pro Asp Trp Ile Gly Gln Ser Tyr Ser Glu Val Met 
    50                  55                  60                  


Ser Leu Asn Glu His Ser Met Gln Ala Leu Ser Trp Arg Lys Leu Tyr 
65                  70                  75                  80  


Leu Ser Arg Ala Lys Leu Lys Ala Ser Ser Arg Thr Ser Ala Leu Leu 
                85                  90                  95      


Ser Gly Phe Ala Met Val Ala Met Val Glu Val Gln Leu Asp Ala Asp 
            100                 105                 110         


His Asp Tyr Pro Pro Gly Leu Leu Ile Ala Phe Ser Ala Cys Thr Thr 
        115                 120                 125             


Val Leu Val Ala Val His Leu Phe Ala Leu Met Ile Ser Thr Cys Ile 
    130                 135                 140                 


Leu Pro Asn Ile Glu Ala Val Ser Asn Val His Asn Leu Asn Ser Val 
145                 150                 155                 160 


Lys Glu Ser Pro His Glu Arg Met His Arg His Ile Glu Leu Ala Trp 
                165                 170                 175     


Ala Phe Ser Thr Val Ile Gly Thr Leu Leu Phe Leu Ala Glu Val Val 
            180                 185                 190         


Leu Leu Cys Trp Val Lys Phe Leu Pro Leu Lys Arg Gln Ala Gly Gln 
        195                 200                 205             


Pro Arg Pro Thr Ser Lys Pro Pro Ala Ser Gly Ala Ala Ala Asn His 
    210                 215                 220                 


Ser Asp Ser Ser Gly Ile Thr Pro Gly Gln Ala Ala Ala Ile Ala Ser 
225                 230                 235                 240 


Thr Thr Ile Met Val Pro Phe Gly Leu Ile Phe Ile Val Phe Ala Val 
                245                 250                 255     


His Phe Tyr Arg Ser Leu Val Ser His Lys Thr Asp Arg Gln Phe Gln 
            260                 265                 270         


Glu Leu Asn Glu Leu Ala Glu Phe Ala Arg Leu Gln Asp Gln Leu Asp 
        275                 280                 285             


His Arg Gly Asp His Pro Leu Thr Pro Gly Ser His Tyr Ala 
    290                 295                 300         


<210>  193
<211>  36
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Forward primer sequence

<400>  193
gcgccgccgc caacgtcagc accagcagcg gcatca                                 36


<210>  194
<211>  36
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Reverse primer sequence

<400>  194
tgatgccgct gctggtgctg acgttggcgg cggcgc                                 36


<210>  195
<211>  11
<212>  PRT
<213>  Mus musculus


<220>
<221>  MISC_FEATURE
<223>  218-228 of SEQ ID NO:72

<400>  195

Ala Glu Ser Val Ile Val Ala Asn His Ser Asp 
1               5                   10      


<210>  196
<211>  11
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<223>  216-226 of SEQ ID NO:2

<400>  196

Pro Ala Ser Gly Ala Ala Ala Asn Val Ser Thr 
1               5                   10      


<210>  197
<211>  909
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  hORAI1/mORAI1 ECL2 (PASGAAANVST) sequence


<220>
<221>  CDS
<222>  (1)..(909)

<400>  197
atg cat ccg gag ccc gcc ccg ccc ccg agc cgc agc agt ccc gag ctt         48
Met His Pro Glu Pro Ala Pro Pro Pro Ser Arg Ser Ser Pro Glu Leu           
1               5                   10                  15                

ccc cca agc ggc ggc agc acc acc agc ggc agc cgc cgg agc cgc cgc         96
Pro Pro Ser Gly Gly Ser Thr Thr Ser Gly Ser Arg Arg Ser Arg Arg           
            20                  25                  30                    

cgc agc ggg gac ggg gag ccc ccg ggg gcc ccg cca ccg ccg ccg tcc        144
Arg Ser Gly Asp Gly Glu Pro Pro Gly Ala Pro Pro Pro Pro Pro Ser           
        35                  40                  45                        

gcc gtc acc tac ccg gac tgg atc ggc cag agt tac tcc gag gtg atg        192
Ala Val Thr Tyr Pro Asp Trp Ile Gly Gln Ser Tyr Ser Glu Val Met           
    50                  55                  60                            

agc ctc aac gag cac tcc atg cag gcg ctg tcc tgg cgc aag ctc tac        240
Ser Leu Asn Glu His Ser Met Gln Ala Leu Ser Trp Arg Lys Leu Tyr           
65                  70                  75                  80            

ttg agc cgc gcc aag ctt aaa gcc tcc agc cgg acc tcg gct ctg ctc        288
Leu Ser Arg Ala Lys Leu Lys Ala Ser Ser Arg Thr Ser Ala Leu Leu           
                85                  90                  95                

tcc ggc ttc gcc atg gtg gca atg gtg gag gtg cag ctg gac gct gac        336
Ser Gly Phe Ala Met Val Ala Met Val Glu Val Gln Leu Asp Ala Asp           
            100                 105                 110                   

cac gac tac cca ccg ggg ctg ctc atc gcc ttc agt gcc tgc acc aca        384
His Asp Tyr Pro Pro Gly Leu Leu Ile Ala Phe Ser Ala Cys Thr Thr           
        115                 120                 125                       

gtg ctg gtg gct gtg cac ctg ttt gcg ctc atg atc agc acc tgc atc        432
Val Leu Val Ala Val His Leu Phe Ala Leu Met Ile Ser Thr Cys Ile           
    130                 135                 140                           

ctg ccc aac atc gag gcg gtg agc aac gtg cac aat ctc aac tcg gtc        480
Leu Pro Asn Ile Glu Ala Val Ser Asn Val His Asn Leu Asn Ser Val           
145                 150                 155                 160           

aag gag tcc ccc cat gag cgc atg cac cgc cac atc gag ctg gcc tgg        528
Lys Glu Ser Pro His Glu Arg Met His Arg His Ile Glu Leu Ala Trp           
                165                 170                 175               

gcc ttc tcc acc gtc atc ggc acg ctg ctc ttc cta gct gag gtg gtg        576
Ala Phe Ser Thr Val Ile Gly Thr Leu Leu Phe Leu Ala Glu Val Val           
            180                 185                 190                   

ctg ctc tgc tgg gtc aag ttc ttg ccc ctc aag agg caa gcg gga cag        624
Leu Leu Cys Trp Val Lys Phe Leu Pro Leu Lys Arg Gln Ala Gly Gln           
        195                 200                 205                       

cca agc ccc acc aag cct ccc cct gca tca ggc gcc gcc gcc aac gtc        672
Pro Ser Pro Thr Lys Pro Pro Pro Ala Ser Gly Ala Ala Ala Asn Val           
    210                 215                 220                           

agc acc agc agc ggc atc acc ccg ggc cag gca gct gcc atc gct tcg        720
Ser Thr Ser Ser Gly Ile Thr Pro Gly Gln Ala Ala Ala Ile Ala Ser           
225                 230                 235                 240           

acc acc atc atg gtg ccc ttc ggc ctg atc ttt atc gtc ttc gcc gtc        768
Thr Thr Ile Met Val Pro Phe Gly Leu Ile Phe Ile Val Phe Ala Val           
                245                 250                 255               

cac ttc tac cgc tca ctg gtt agc cat aag acc gac cga cag ttc cag        816
His Phe Tyr Arg Ser Leu Val Ser His Lys Thr Asp Arg Gln Phe Gln           
            260                 265                 270                   

gag ctc aac gag ctg gcg gag ttt gcc cgc tta cag gac cag ctg gac        864
Glu Leu Asn Glu Leu Ala Glu Phe Ala Arg Leu Gln Asp Gln Leu Asp           
        275                 280                 285                       

cac aga ggg gac cac ccc ctg acg ccc ggc agc cac tat gcc tag            909
His Arg Gly Asp His Pro Leu Thr Pro Gly Ser His Tyr Ala                   
    290                 295                 300                           


<210>  198
<211>  302
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  198

Met His Pro Glu Pro Ala Pro Pro Pro Ser Arg Ser Ser Pro Glu Leu 
1               5                   10                  15      


Pro Pro Ser Gly Gly Ser Thr Thr Ser Gly Ser Arg Arg Ser Arg Arg 
            20                  25                  30          


Arg Ser Gly Asp Gly Glu Pro Pro Gly Ala Pro Pro Pro Pro Pro Ser 
        35                  40                  45              


Ala Val Thr Tyr Pro Asp Trp Ile Gly Gln Ser Tyr Ser Glu Val Met 
    50                  55                  60                  


Ser Leu Asn Glu His Ser Met Gln Ala Leu Ser Trp Arg Lys Leu Tyr 
65                  70                  75                  80  


Leu Ser Arg Ala Lys Leu Lys Ala Ser Ser Arg Thr Ser Ala Leu Leu 
                85                  90                  95      


Ser Gly Phe Ala Met Val Ala Met Val Glu Val Gln Leu Asp Ala Asp 
            100                 105                 110         


His Asp Tyr Pro Pro Gly Leu Leu Ile Ala Phe Ser Ala Cys Thr Thr 
        115                 120                 125             


Val Leu Val Ala Val His Leu Phe Ala Leu Met Ile Ser Thr Cys Ile 
    130                 135                 140                 


Leu Pro Asn Ile Glu Ala Val Ser Asn Val His Asn Leu Asn Ser Val 
145                 150                 155                 160 


Lys Glu Ser Pro His Glu Arg Met His Arg His Ile Glu Leu Ala Trp 
                165                 170                 175     


Ala Phe Ser Thr Val Ile Gly Thr Leu Leu Phe Leu Ala Glu Val Val 
            180                 185                 190         


Leu Leu Cys Trp Val Lys Phe Leu Pro Leu Lys Arg Gln Ala Gly Gln 
        195                 200                 205             


Pro Ser Pro Thr Lys Pro Pro Pro Ala Ser Gly Ala Ala Ala Asn Val 
    210                 215                 220                 


Ser Thr Ser Ser Gly Ile Thr Pro Gly Gln Ala Ala Ala Ile Ala Ser 
225                 230                 235                 240 


Thr Thr Ile Met Val Pro Phe Gly Leu Ile Phe Ile Val Phe Ala Val 
                245                 250                 255     


His Phe Tyr Arg Ser Leu Val Ser His Lys Thr Asp Arg Gln Phe Gln 
            260                 265                 270         


Glu Leu Asn Glu Leu Ala Glu Phe Ala Arg Leu Gln Asp Gln Leu Asp 
        275                 280                 285             


His Arg Gly Asp His Pro Leu Thr Pro Gly Ser His Tyr Ala 
    290                 295                 300         


<210>  199
<211>  34
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Forward primer sequence

<400>  199
agttcttgcc cctcaagaag caaccgggac agcc                                   34


<210>  200
<211>  34
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Reverse primer sequence

<400>  200
ggctgtcccg gttgcttctt gaggggcaag aact                                   34


<210>  201
<211>  14
<212>  PRT
<213>  Mus musculus


<220>
<221>  MISC_FEATURE
<223>  206 to 219 of SEQ ID NO:72

<400>  201

Arg Gln Ala Gly Gln Pro Ser Pro Thr Lys Pro Pro Ala Glu 
1               5                   10                  


<210>  202
<211>  14
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<223>  204 to 217 of SEQ ID NO:2

<400>  202

Lys Gln Pro Gly Gln Pro Arg Pro Thr Ser Lys Pro Pro Ala 
1               5                   10                  


<210>  203
<211>  909
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  hORAI1/mORAI1 ECL2 (KQPGQPRPTSKPPA) sequence


<220>
<221>  CDS
<222>  (1)..(909)

<400>  203
atg cat ccg gag ccc gcc ccg ccc ccg agc cgc agc agt ccc gag ctt         48
Met His Pro Glu Pro Ala Pro Pro Pro Ser Arg Ser Ser Pro Glu Leu           
1               5                   10                  15                

ccc cca agc ggc ggc agc acc acc agc ggc agc cgc cgg agc cgc cgc         96
Pro Pro Ser Gly Gly Ser Thr Thr Ser Gly Ser Arg Arg Ser Arg Arg           
            20                  25                  30                    

cgc agc ggg gac ggg gag ccc ccg ggg gcc ccg cca ccg ccg ccg tcc        144
Arg Ser Gly Asp Gly Glu Pro Pro Gly Ala Pro Pro Pro Pro Pro Ser           
        35                  40                  45                        

gcc gtc acc tac ccg gac tgg atc ggc cag agt tac tcc gag gtg atg        192
Ala Val Thr Tyr Pro Asp Trp Ile Gly Gln Ser Tyr Ser Glu Val Met           
    50                  55                  60                            

agc ctc aac gag cac tcc atg cag gcg ctg tcc tgg cgc aag ctc tac        240
Ser Leu Asn Glu His Ser Met Gln Ala Leu Ser Trp Arg Lys Leu Tyr           
65                  70                  75                  80            

ttg agc cgc gcc aag ctt aaa gcc tcc agc cgg acc tcg gct ctg ctc        288
Leu Ser Arg Ala Lys Leu Lys Ala Ser Ser Arg Thr Ser Ala Leu Leu           
                85                  90                  95                

tcc ggc ttc gcc atg gtg gca atg gtg gag gtg cag ctg gac gct gac        336
Ser Gly Phe Ala Met Val Ala Met Val Glu Val Gln Leu Asp Ala Asp           
            100                 105                 110                   

cac gac tac cca ccg ggg ctg ctc atc gcc ttc agt gcc tgc acc aca        384
His Asp Tyr Pro Pro Gly Leu Leu Ile Ala Phe Ser Ala Cys Thr Thr           
        115                 120                 125                       

gtg ctg gtg gct gtg cac ctg ttt gcg ctc atg atc agc acc tgc atc        432
Val Leu Val Ala Val His Leu Phe Ala Leu Met Ile Ser Thr Cys Ile           
    130                 135                 140                           

ctg ccc aac atc gag gcg gtg agc aac gtg cac aat ctc aac tcg gtc        480
Leu Pro Asn Ile Glu Ala Val Ser Asn Val His Asn Leu Asn Ser Val           
145                 150                 155                 160           

aag gag tcc ccc cat gag cgc atg cac cgc cac atc gag ctg gcc tgg        528
Lys Glu Ser Pro His Glu Arg Met His Arg His Ile Glu Leu Ala Trp           
                165                 170                 175               

gcc ttc tcc acc gtc atc ggc acg ctg ctc ttc cta gct gag gtg gtg        576
Ala Phe Ser Thr Val Ile Gly Thr Leu Leu Phe Leu Ala Glu Val Val           
            180                 185                 190                   

ctg ctc tgc tgg gtc aag ttc ttg ccc ctc aag aag caa ccg gga cag        624
Leu Leu Cys Trp Val Lys Phe Leu Pro Leu Lys Lys Gln Pro Gly Gln           
        195                 200                 205                       

cca agg ccc acc agc aag ccc cct gca tca gtc atc gtc gcc aac cac        672
Pro Arg Pro Thr Ser Lys Pro Pro Ala Ser Val Ile Val Ala Asn His           
    210                 215                 220                           

agc gac agc agc ggc atc acc ccg ggc cag gca gct gcc atc gct tcg        720
Ser Asp Ser Ser Gly Ile Thr Pro Gly Gln Ala Ala Ala Ile Ala Ser           
225                 230                 235                 240           

acc acc atc atg gtg ccc ttc ggc ctg atc ttt atc gtc ttc gcc gtc        768
Thr Thr Ile Met Val Pro Phe Gly Leu Ile Phe Ile Val Phe Ala Val           
                245                 250                 255               

cac ttc tac cgc tca ctg gtt agc cat aag acc gac cga cag ttc cag        816
His Phe Tyr Arg Ser Leu Val Ser His Lys Thr Asp Arg Gln Phe Gln           
            260                 265                 270                   

gag ctc aac gag ctg gcg gag ttt gcc cgc tta cag gac cag ctg gac        864
Glu Leu Asn Glu Leu Ala Glu Phe Ala Arg Leu Gln Asp Gln Leu Asp           
        275                 280                 285                       

cac aga ggg gac cac ccc ctg acg ccc ggc agc cac tat gcc tag            909
His Arg Gly Asp His Pro Leu Thr Pro Gly Ser His Tyr Ala                   
    290                 295                 300                           


<210>  204
<211>  302
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  204

Met His Pro Glu Pro Ala Pro Pro Pro Ser Arg Ser Ser Pro Glu Leu 
1               5                   10                  15      


Pro Pro Ser Gly Gly Ser Thr Thr Ser Gly Ser Arg Arg Ser Arg Arg 
            20                  25                  30          


Arg Ser Gly Asp Gly Glu Pro Pro Gly Ala Pro Pro Pro Pro Pro Ser 
        35                  40                  45              


Ala Val Thr Tyr Pro Asp Trp Ile Gly Gln Ser Tyr Ser Glu Val Met 
    50                  55                  60                  


Ser Leu Asn Glu His Ser Met Gln Ala Leu Ser Trp Arg Lys Leu Tyr 
65                  70                  75                  80  


Leu Ser Arg Ala Lys Leu Lys Ala Ser Ser Arg Thr Ser Ala Leu Leu 
                85                  90                  95      


Ser Gly Phe Ala Met Val Ala Met Val Glu Val Gln Leu Asp Ala Asp 
            100                 105                 110         


His Asp Tyr Pro Pro Gly Leu Leu Ile Ala Phe Ser Ala Cys Thr Thr 
        115                 120                 125             


Val Leu Val Ala Val His Leu Phe Ala Leu Met Ile Ser Thr Cys Ile 
    130                 135                 140                 


Leu Pro Asn Ile Glu Ala Val Ser Asn Val His Asn Leu Asn Ser Val 
145                 150                 155                 160 


Lys Glu Ser Pro His Glu Arg Met His Arg His Ile Glu Leu Ala Trp 
                165                 170                 175     


Ala Phe Ser Thr Val Ile Gly Thr Leu Leu Phe Leu Ala Glu Val Val 
            180                 185                 190         


Leu Leu Cys Trp Val Lys Phe Leu Pro Leu Lys Lys Gln Pro Gly Gln 
        195                 200                 205             


Pro Arg Pro Thr Ser Lys Pro Pro Ala Ser Val Ile Val Ala Asn His 
    210                 215                 220                 


Ser Asp Ser Ser Gly Ile Thr Pro Gly Gln Ala Ala Ala Ile Ala Ser 
225                 230                 235                 240 


Thr Thr Ile Met Val Pro Phe Gly Leu Ile Phe Ile Val Phe Ala Val 
                245                 250                 255     


His Phe Tyr Arg Ser Leu Val Ser His Lys Thr Asp Arg Gln Phe Gln 
            260                 265                 270         


Glu Leu Asn Glu Leu Ala Glu Phe Ala Arg Leu Gln Asp Gln Leu Asp 
        275                 280                 285             


His Arg Gly Asp His Pro Leu Thr Pro Gly Ser His Tyr Ala 
    290                 295                 300         


<210>  205
<211>  39
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Forward primer sequence

<400>  205
aagccccctg catcaggcgc cgccgccaac cacagcgac                              39


<210>  206
<211>  39
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Reverse primer sequence

<400>  206
gtcgctgtgg ttggcggcgg cgcctgatgc agggggctt                              39


<210>  207
<211>  18
<212>  PRT
<213>  Mus musculus


<220>
<221>  MISC_FEATURE
<223>  206 to 223 of SEQ ID NO:72

<400>  207

Arg Gln Ala Gly Gln Pro Ser Pro Thr Lys Pro Pro Ala Glu Ser Val 
1               5                   10                  15      


Ile Val 
        


<210>  208
<211>  18
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<223>  204 to 221 of SEQ ID NO:2

<400>  208

Lys Gln Pro Gly Gln Pro Arg Pro Thr Ser Lys Pro Pro Ala Ser Gly 
1               5                   10                  15      


Ala Ala 
        


<210>  209
<211>  909
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  hORAI1/mORAI1 ECL2 (KQPGQPRPTSKPPASGAA) sequence


<220>
<221>  CDS
<222>  (1)..(909)

<400>  209
atg cat ccg gag ccc gcc ccg ccc ccg agc cgc agc agt ccc gag ctt         48
Met His Pro Glu Pro Ala Pro Pro Pro Ser Arg Ser Ser Pro Glu Leu           
1               5                   10                  15                

ccc cca agc ggc ggc agc acc acc agc ggc agc cgc cgg agc cgc cgc         96
Pro Pro Ser Gly Gly Ser Thr Thr Ser Gly Ser Arg Arg Ser Arg Arg           
            20                  25                  30                    

cgc agc ggg gac ggg gag ccc ccg ggg gcc ccg cca ccg ccg ccg tcc        144
Arg Ser Gly Asp Gly Glu Pro Pro Gly Ala Pro Pro Pro Pro Pro Ser           
        35                  40                  45                        

gcc gtc acc tac ccg gac tgg atc ggc cag agt tac tcc gag gtg atg        192
Ala Val Thr Tyr Pro Asp Trp Ile Gly Gln Ser Tyr Ser Glu Val Met           
    50                  55                  60                            

agc ctc aac gag cac tcc atg cag gcg ctg tcc tgg cgc aag ctc tac        240
Ser Leu Asn Glu His Ser Met Gln Ala Leu Ser Trp Arg Lys Leu Tyr           
65                  70                  75                  80            

ttg agc cgc gcc aag ctt aaa gcc tcc agc cgg acc tcg gct ctg ctc        288
Leu Ser Arg Ala Lys Leu Lys Ala Ser Ser Arg Thr Ser Ala Leu Leu           
                85                  90                  95                

tcc ggc ttc gcc atg gtg gca atg gtg gag gtg cag ctg gac gct gac        336
Ser Gly Phe Ala Met Val Ala Met Val Glu Val Gln Leu Asp Ala Asp           
            100                 105                 110                   

cac gac tac cca ccg ggg ctg ctc atc gcc ttc agt gcc tgc acc aca        384
His Asp Tyr Pro Pro Gly Leu Leu Ile Ala Phe Ser Ala Cys Thr Thr           
        115                 120                 125                       

gtg ctg gtg gct gtg cac ctg ttt gcg ctc atg atc agc acc tgc atc        432
Val Leu Val Ala Val His Leu Phe Ala Leu Met Ile Ser Thr Cys Ile           
    130                 135                 140                           

ctg ccc aac atc gag gcg gtg agc aac gtg cac aat ctc aac tcg gtc        480
Leu Pro Asn Ile Glu Ala Val Ser Asn Val His Asn Leu Asn Ser Val           
145                 150                 155                 160           

aag gag tcc ccc cat gag cgc atg cac cgc cac atc gag ctg gcc tgg        528
Lys Glu Ser Pro His Glu Arg Met His Arg His Ile Glu Leu Ala Trp           
                165                 170                 175               

gcc ttc tcc acc gtc atc ggc acg ctg ctc ttc cta gct gag gtg gtg        576
Ala Phe Ser Thr Val Ile Gly Thr Leu Leu Phe Leu Ala Glu Val Val           
            180                 185                 190                   

ctg ctc tgc tgg gtc aag ttc ttg ccc ctc aag aag caa ccg gga cag        624
Leu Leu Cys Trp Val Lys Phe Leu Pro Leu Lys Lys Gln Pro Gly Gln           
        195                 200                 205                       

cca agg ccc acc agc aag ccc cct gca tca ggc gcc gcc gcc aac cac        672
Pro Arg Pro Thr Ser Lys Pro Pro Ala Ser Gly Ala Ala Ala Asn His           
    210                 215                 220                           

agc gac agc agc ggc atc acc ccg ggc cag gca gct gcc atc gct tcg        720
Ser Asp Ser Ser Gly Ile Thr Pro Gly Gln Ala Ala Ala Ile Ala Ser           
225                 230                 235                 240           

acc acc atc atg gtg ccc ttc ggc ctg atc ttt atc gtc ttc gcc gtc        768
Thr Thr Ile Met Val Pro Phe Gly Leu Ile Phe Ile Val Phe Ala Val           
                245                 250                 255               

cac ttc tac cgc tca ctg gtt agc cat aag acc gac cga cag ttc cag        816
His Phe Tyr Arg Ser Leu Val Ser His Lys Thr Asp Arg Gln Phe Gln           
            260                 265                 270                   

gag ctc aac gag ctg gcg gag ttt gcc cgc tta cag gac cag ctg gac        864
Glu Leu Asn Glu Leu Ala Glu Phe Ala Arg Leu Gln Asp Gln Leu Asp           
        275                 280                 285                       

cac aga ggg gac cac ccc ctg acg ccc ggc agc cac tat gcc tag            909
His Arg Gly Asp His Pro Leu Thr Pro Gly Ser His Tyr Ala                   
    290                 295                 300                           


<210>  210
<211>  302
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  210

Met His Pro Glu Pro Ala Pro Pro Pro Ser Arg Ser Ser Pro Glu Leu 
1               5                   10                  15      


Pro Pro Ser Gly Gly Ser Thr Thr Ser Gly Ser Arg Arg Ser Arg Arg 
            20                  25                  30          


Arg Ser Gly Asp Gly Glu Pro Pro Gly Ala Pro Pro Pro Pro Pro Ser 
        35                  40                  45              


Ala Val Thr Tyr Pro Asp Trp Ile Gly Gln Ser Tyr Ser Glu Val Met 
    50                  55                  60                  


Ser Leu Asn Glu His Ser Met Gln Ala Leu Ser Trp Arg Lys Leu Tyr 
65                  70                  75                  80  


Leu Ser Arg Ala Lys Leu Lys Ala Ser Ser Arg Thr Ser Ala Leu Leu 
                85                  90                  95      


Ser Gly Phe Ala Met Val Ala Met Val Glu Val Gln Leu Asp Ala Asp 
            100                 105                 110         


His Asp Tyr Pro Pro Gly Leu Leu Ile Ala Phe Ser Ala Cys Thr Thr 
        115                 120                 125             


Val Leu Val Ala Val His Leu Phe Ala Leu Met Ile Ser Thr Cys Ile 
    130                 135                 140                 


Leu Pro Asn Ile Glu Ala Val Ser Asn Val His Asn Leu Asn Ser Val 
145                 150                 155                 160 


Lys Glu Ser Pro His Glu Arg Met His Arg His Ile Glu Leu Ala Trp 
                165                 170                 175     


Ala Phe Ser Thr Val Ile Gly Thr Leu Leu Phe Leu Ala Glu Val Val 
            180                 185                 190         


Leu Leu Cys Trp Val Lys Phe Leu Pro Leu Lys Lys Gln Pro Gly Gln 
        195                 200                 205             


Pro Arg Pro Thr Ser Lys Pro Pro Ala Ser Gly Ala Ala Ala Asn His 
    210                 215                 220                 


Ser Asp Ser Ser Gly Ile Thr Pro Gly Gln Ala Ala Ala Ile Ala Ser 
225                 230                 235                 240 


Thr Thr Ile Met Val Pro Phe Gly Leu Ile Phe Ile Val Phe Ala Val 
                245                 250                 255     


His Phe Tyr Arg Ser Leu Val Ser His Lys Thr Asp Arg Gln Phe Gln 
            260                 265                 270         


Glu Leu Asn Glu Leu Ala Glu Phe Ala Arg Leu Gln Asp Gln Leu Asp 
        275                 280                 285             


His Arg Gly Asp His Pro Leu Thr Pro Gly Ser His Tyr Ala 
    290                 295                 300         


<210>  211
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Forward primer sequence

<400>  211
ggccagccaa gccccaccaa gcc                                               23


<210>  212
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Reverse primer sequence

<400>  212
ggcttggtgg ggcttggctg gcc                                               23


<210>  213
<211>  912
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  mORAI1/hORAI1 ECL2 (SPTKPPAE) sequence


<220>
<221>  CDS
<222>  (1)..(912)

<400>  213
atg cat ccg gag cct gcc ccg ccc ccg agt cac agc aat ccg gag ctt         48
Met His Pro Glu Pro Ala Pro Pro Pro Ser His Ser Asn Pro Glu Leu           
1               5                   10                  15                

ccc gtg agc ggc ggc agc agc act agc ggc agc cgc cgg agc cgc cgc         96
Pro Val Ser Gly Gly Ser Ser Thr Ser Gly Ser Arg Arg Ser Arg Arg           
            20                  25                  30                    

cgc agc ggg gac ggg gag ccc tcg ggg gcc cca ccg ctg ccg ccg ccg        144
Arg Ser Gly Asp Gly Glu Pro Ser Gly Ala Pro Pro Leu Pro Pro Pro           
        35                  40                  45                        

cca ccc gcc gtc agc tac ccg gac tgg atc ggc cag agt tac tcc gag        192
Pro Pro Ala Val Ser Tyr Pro Asp Trp Ile Gly Gln Ser Tyr Ser Glu           
    50                  55                  60                            

gtg atg agc ctc aac gag cac tcg atg cag gcg ctg tcc tgg cgc aag        240
Val Met Ser Leu Asn Glu His Ser Met Gln Ala Leu Ser Trp Arg Lys           
65                  70                  75                  80            

ctc tac tta agc cgc gcc aag ctc aaa gct tcc agc cgg acc tcg gct        288
Leu Tyr Leu Ser Arg Ala Lys Leu Lys Ala Ser Ser Arg Thr Ser Ala           
                85                  90                  95                

ctg ctc tcc ggc ttc gcc atg gta gcg atg gtg gaa gtc cag ctg gac        336
Leu Leu Ser Gly Phe Ala Met Val Ala Met Val Glu Val Gln Leu Asp           
            100                 105                 110                   

aca gac cat gac tac cca cca ggg ttg ctc atc gtc ttt agt gcc tgc        384
Thr Asp His Asp Tyr Pro Pro Gly Leu Leu Ile Val Phe Ser Ala Cys           
        115                 120                 125                       

acc aca gtg cta gtg gcc gtg cac ctg ttt gcc ctc atg atc agc acc        432
Thr Thr Val Leu Val Ala Val His Leu Phe Ala Leu Met Ile Ser Thr           
    130                 135                 140                           

tgc atc ctg ccc aac atc gag gct gtg agc aac gtc cac aac ctc aac        480
Cys Ile Leu Pro Asn Ile Glu Ala Val Ser Asn Val His Asn Leu Asn           
145                 150                 155                 160           

tcg gtc aaa gag tca ccc cac gag cgc atg cat cgc cac atc gag ctg        528
Ser Val Lys Glu Ser Pro His Glu Arg Met His Arg His Ile Glu Leu           
                165                 170                 175               

gcc tgg gcc ttc tcc acg gtc atc ggg acg ctg ctt ttc cta gca gag        576
Ala Trp Ala Phe Ser Thr Val Ile Gly Thr Leu Leu Phe Leu Ala Glu           
            180                 185                 190                   

gtc gtg ctg ctc tgc tgg gtc aag ttc tta cct ctc aag aag cag cca        624
Val Val Leu Leu Cys Trp Val Lys Phe Leu Pro Leu Lys Lys Gln Pro           
        195                 200                 205                       

ggc cag cca agc ccc acc aag ccg ccc gcc gag agt ggc gca gca gcc        672
Gly Gln Pro Ser Pro Thr Lys Pro Pro Ala Glu Ser Gly Ala Ala Ala           
    210                 215                 220                           

aac gtc agc acc agc ggc atc acc ccg ggt gag gcg gca gcc att gcc        720
Asn Val Ser Thr Ser Gly Ile Thr Pro Gly Glu Ala Ala Ala Ile Ala           
225                 230                 235                 240           

tcc acc gcc atc atg gtt ccc tgt ggc ctg gtt ttc atc gtc ttt gct        768
Ser Thr Ala Ile Met Val Pro Cys Gly Leu Val Phe Ile Val Phe Ala           
                245                 250                 255               

gtt cac ttc tac cgc tcc ctg gtc agc cat aag acg gac cgg cag ttc        816
Val His Phe Tyr Arg Ser Leu Val Ser His Lys Thr Asp Arg Gln Phe           
            260                 265                 270                   

cag gag ctc aat gag ctg gcc gag ttt gcc cgc ttg cag gac cag ctg        864
Gln Glu Leu Asn Glu Leu Ala Glu Phe Ala Arg Leu Gln Asp Gln Leu           
        275                 280                 285                       

gac cac aga ggg gac cat tct cta aca ccg ggc acc cac tat gcc taa        912
Asp His Arg Gly Asp His Ser Leu Thr Pro Gly Thr His Tyr Ala               
    290                 295                 300                           


<210>  214
<211>  303
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  214

Met His Pro Glu Pro Ala Pro Pro Pro Ser His Ser Asn Pro Glu Leu 
1               5                   10                  15      


Pro Val Ser Gly Gly Ser Ser Thr Ser Gly Ser Arg Arg Ser Arg Arg 
            20                  25                  30          


Arg Ser Gly Asp Gly Glu Pro Ser Gly Ala Pro Pro Leu Pro Pro Pro 
        35                  40                  45              


Pro Pro Ala Val Ser Tyr Pro Asp Trp Ile Gly Gln Ser Tyr Ser Glu 
    50                  55                  60                  


Val Met Ser Leu Asn Glu His Ser Met Gln Ala Leu Ser Trp Arg Lys 
65                  70                  75                  80  


Leu Tyr Leu Ser Arg Ala Lys Leu Lys Ala Ser Ser Arg Thr Ser Ala 
                85                  90                  95      


Leu Leu Ser Gly Phe Ala Met Val Ala Met Val Glu Val Gln Leu Asp 
            100                 105                 110         


Thr Asp His Asp Tyr Pro Pro Gly Leu Leu Ile Val Phe Ser Ala Cys 
        115                 120                 125             


Thr Thr Val Leu Val Ala Val His Leu Phe Ala Leu Met Ile Ser Thr 
    130                 135                 140                 


Cys Ile Leu Pro Asn Ile Glu Ala Val Ser Asn Val His Asn Leu Asn 
145                 150                 155                 160 


Ser Val Lys Glu Ser Pro His Glu Arg Met His Arg His Ile Glu Leu 
                165                 170                 175     


Ala Trp Ala Phe Ser Thr Val Ile Gly Thr Leu Leu Phe Leu Ala Glu 
            180                 185                 190         


Val Val Leu Leu Cys Trp Val Lys Phe Leu Pro Leu Lys Lys Gln Pro 
        195                 200                 205             


Gly Gln Pro Ser Pro Thr Lys Pro Pro Ala Glu Ser Gly Ala Ala Ala 
    210                 215                 220                 


Asn Val Ser Thr Ser Gly Ile Thr Pro Gly Glu Ala Ala Ala Ile Ala 
225                 230                 235                 240 


Ser Thr Ala Ile Met Val Pro Cys Gly Leu Val Phe Ile Val Phe Ala 
                245                 250                 255     


Val His Phe Tyr Arg Ser Leu Val Ser His Lys Thr Asp Arg Gln Phe 
            260                 265                 270         


Gln Glu Leu Asn Glu Leu Ala Glu Phe Ala Arg Leu Gln Asp Gln Leu 
        275                 280                 285             


Asp His Arg Gly Asp His Ser Leu Thr Pro Gly Thr His Tyr Ala 
    290                 295                 300             


<210>  215
<211>  39
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Forward primer sequence

<400>  215
ccgcccgccg agagtgtcat agtagccaac gtcagcacc                              39


<210>  216
<211>  39
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Reverse primer sequence

<400>  216
ggtgctgacg ttggctacta tgacactctc ggcgggcgg                              39


<210>  217
<211>  912
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  mORAI1/hORAI1 ECL2 (SPTKPPAESVIV) sequence


<220>
<221>  CDS
<222>  (1)..(912)

<400>  217
atg cat ccg gag cct gcc ccg ccc ccg agt cac agc aat ccg gag ctt         48
Met His Pro Glu Pro Ala Pro Pro Pro Ser His Ser Asn Pro Glu Leu           
1               5                   10                  15                

ccc gtg agc ggc ggc agc agc act agc ggc agc cgc cgg agc cgc cgc         96
Pro Val Ser Gly Gly Ser Ser Thr Ser Gly Ser Arg Arg Ser Arg Arg           
            20                  25                  30                    

cgc agc ggg gac ggg gag ccc tcg ggg gcc cca ccg ctg ccg ccg ccg        144
Arg Ser Gly Asp Gly Glu Pro Ser Gly Ala Pro Pro Leu Pro Pro Pro           
        35                  40                  45                        

cca ccc gcc gtc agc tac ccg gac tgg atc ggc cag agt tac tcc gag        192
Pro Pro Ala Val Ser Tyr Pro Asp Trp Ile Gly Gln Ser Tyr Ser Glu           
    50                  55                  60                            

gtg atg agc ctc aac gag cac tcg atg cag gcg ctg tcc tgg cgc aag        240
Val Met Ser Leu Asn Glu His Ser Met Gln Ala Leu Ser Trp Arg Lys           
65                  70                  75                  80            

ctc tac tta agc cgc gcc aag ctc aaa gct tcc agc cgg acc tcg gct        288
Leu Tyr Leu Ser Arg Ala Lys Leu Lys Ala Ser Ser Arg Thr Ser Ala           
                85                  90                  95                

ctg ctc tcc ggc ttc gcc atg gta gcg atg gtg gaa gtc cag ctg gac        336
Leu Leu Ser Gly Phe Ala Met Val Ala Met Val Glu Val Gln Leu Asp           
            100                 105                 110                   

aca gac cat gac tac cca cca ggg ttg ctc atc gtc ttt agt gcc tgc        384
Thr Asp His Asp Tyr Pro Pro Gly Leu Leu Ile Val Phe Ser Ala Cys           
        115                 120                 125                       

acc aca gtg cta gtg gcc gtg cac ctg ttt gcc ctc atg atc agc acc        432
Thr Thr Val Leu Val Ala Val His Leu Phe Ala Leu Met Ile Ser Thr           
    130                 135                 140                           

tgc atc ctg ccc aac atc gag gct gtg agc aac gtc cac aac ctc aac        480
Cys Ile Leu Pro Asn Ile Glu Ala Val Ser Asn Val His Asn Leu Asn           
145                 150                 155                 160           

tcg gtc aaa gag tca ccc cac gag cgc atg cat cgc cac atc gag ctg        528
Ser Val Lys Glu Ser Pro His Glu Arg Met His Arg His Ile Glu Leu           
                165                 170                 175               

gcc tgg gcc ttc tcc acg gtc atc ggg acg ctg ctt ttc cta gca gag        576
Ala Trp Ala Phe Ser Thr Val Ile Gly Thr Leu Leu Phe Leu Ala Glu           
            180                 185                 190                   

gtc gtg ctg ctc tgc tgg gtc aag ttc tta cct ctc aag aag cag cca        624
Val Val Leu Leu Cys Trp Val Lys Phe Leu Pro Leu Lys Lys Gln Pro           
        195                 200                 205                       

ggc cag cca agc ccc acc aag ccg ccc gcc gag agt gtc ata gta gcc        672
Gly Gln Pro Ser Pro Thr Lys Pro Pro Ala Glu Ser Val Ile Val Ala           
    210                 215                 220                           

aac gtc agc acc agc ggc atc acc ccg ggt gag gcg gca gcc att gcc        720
Asn Val Ser Thr Ser Gly Ile Thr Pro Gly Glu Ala Ala Ala Ile Ala           
225                 230                 235                 240           

tcc acc gcc atc atg gtt ccc tgt ggc ctg gtt ttc atc gtc ttt gct        768
Ser Thr Ala Ile Met Val Pro Cys Gly Leu Val Phe Ile Val Phe Ala           
                245                 250                 255               

gtt cac ttc tac cgc tcc ctg gtc agc cat aag acg gac cgg cag ttc        816
Val His Phe Tyr Arg Ser Leu Val Ser His Lys Thr Asp Arg Gln Phe           
            260                 265                 270                   

cag gag ctc aat gag ctg gcc gag ttt gcc cgc ttg cag gac cag ctg        864
Gln Glu Leu Asn Glu Leu Ala Glu Phe Ala Arg Leu Gln Asp Gln Leu           
        275                 280                 285                       

gac cac aga ggg gac cat tct cta aca ccg ggc acc cac tat gcc taa        912
Asp His Arg Gly Asp His Ser Leu Thr Pro Gly Thr His Tyr Ala               
    290                 295                 300                           


<210>  218
<211>  303
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  218

Met His Pro Glu Pro Ala Pro Pro Pro Ser His Ser Asn Pro Glu Leu 
1               5                   10                  15      


Pro Val Ser Gly Gly Ser Ser Thr Ser Gly Ser Arg Arg Ser Arg Arg 
            20                  25                  30          


Arg Ser Gly Asp Gly Glu Pro Ser Gly Ala Pro Pro Leu Pro Pro Pro 
        35                  40                  45              


Pro Pro Ala Val Ser Tyr Pro Asp Trp Ile Gly Gln Ser Tyr Ser Glu 
    50                  55                  60                  


Val Met Ser Leu Asn Glu His Ser Met Gln Ala Leu Ser Trp Arg Lys 
65                  70                  75                  80  


Leu Tyr Leu Ser Arg Ala Lys Leu Lys Ala Ser Ser Arg Thr Ser Ala 
                85                  90                  95      


Leu Leu Ser Gly Phe Ala Met Val Ala Met Val Glu Val Gln Leu Asp 
            100                 105                 110         


Thr Asp His Asp Tyr Pro Pro Gly Leu Leu Ile Val Phe Ser Ala Cys 
        115                 120                 125             


Thr Thr Val Leu Val Ala Val His Leu Phe Ala Leu Met Ile Ser Thr 
    130                 135                 140                 


Cys Ile Leu Pro Asn Ile Glu Ala Val Ser Asn Val His Asn Leu Asn 
145                 150                 155                 160 


Ser Val Lys Glu Ser Pro His Glu Arg Met His Arg His Ile Glu Leu 
                165                 170                 175     


Ala Trp Ala Phe Ser Thr Val Ile Gly Thr Leu Leu Phe Leu Ala Glu 
            180                 185                 190         


Val Val Leu Leu Cys Trp Val Lys Phe Leu Pro Leu Lys Lys Gln Pro 
        195                 200                 205             


Gly Gln Pro Ser Pro Thr Lys Pro Pro Ala Glu Ser Val Ile Val Ala 
    210                 215                 220                 


Asn Val Ser Thr Ser Gly Ile Thr Pro Gly Glu Ala Ala Ala Ile Ala 
225                 230                 235                 240 


Ser Thr Ala Ile Met Val Pro Cys Gly Leu Val Phe Ile Val Phe Ala 
                245                 250                 255     


Val His Phe Tyr Arg Ser Leu Val Ser His Lys Thr Asp Arg Gln Phe 
            260                 265                 270         


Gln Glu Leu Asn Glu Leu Ala Glu Phe Ala Arg Leu Gln Asp Gln Leu 
        275                 280                 285             


Asp His Arg Gly Asp His Ser Leu Thr Pro Gly Thr His Tyr Ala 
    290                 295                 300             


<210>  219
<211>  42
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Forward primer sequence

<400>  219
gtgtcatagt agccaaccac agcgacagcg gcatcacccc gg                          42


<210>  220
<211>  42
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Reverse primer sequence

<400>  220
ccggggtgat gccgctgtcg ctgtggttgg ctactatgac ac                          42


<210>  221
<211>  912
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  mORAI1/hORAI1 ECL2 (AESVIVANHSD) sequence


<220>
<221>  CDS
<222>  (1)..(912)

<400>  221
atg cat ccg gag cct gcc ccg ccc ccg agt cac agc aat ccg gag ctt         48
Met His Pro Glu Pro Ala Pro Pro Pro Ser His Ser Asn Pro Glu Leu           
1               5                   10                  15                

ccc gtg agc ggc ggc agc agc act agc ggc agc cgc cgg agc cgc cgc         96
Pro Val Ser Gly Gly Ser Ser Thr Ser Gly Ser Arg Arg Ser Arg Arg           
            20                  25                  30                    

cgc agc ggg gac ggg gag ccc tcg ggg gcc cca ccg ctg ccg ccg ccg        144
Arg Ser Gly Asp Gly Glu Pro Ser Gly Ala Pro Pro Leu Pro Pro Pro           
        35                  40                  45                        

cca ccc gcc gtc agc tac ccg gac tgg atc ggc cag agt tac tcc gag        192
Pro Pro Ala Val Ser Tyr Pro Asp Trp Ile Gly Gln Ser Tyr Ser Glu           
    50                  55                  60                            

gtg atg agc ctc aac gag cac tcg atg cag gcg ctg tcc tgg cgc aag        240
Val Met Ser Leu Asn Glu His Ser Met Gln Ala Leu Ser Trp Arg Lys           
65                  70                  75                  80            

ctc tac tta agc cgc gcc aag ctc aaa gct tcc agc cgg acc tcg gct        288
Leu Tyr Leu Ser Arg Ala Lys Leu Lys Ala Ser Ser Arg Thr Ser Ala           
                85                  90                  95                

ctg ctc tcc ggc ttc gcc atg gta gcg atg gtg gaa gtc cag ctg gac        336
Leu Leu Ser Gly Phe Ala Met Val Ala Met Val Glu Val Gln Leu Asp           
            100                 105                 110                   

aca gac cat gac tac cca cca ggg ttg ctc atc gtc ttt agt gcc tgc        384
Thr Asp His Asp Tyr Pro Pro Gly Leu Leu Ile Val Phe Ser Ala Cys           
        115                 120                 125                       

acc aca gtg cta gtg gcc gtg cac ctg ttt gcc ctc atg atc agc acc        432
Thr Thr Val Leu Val Ala Val His Leu Phe Ala Leu Met Ile Ser Thr           
    130                 135                 140                           

tgc atc ctg ccc aac atc gag gct gtg agc aac gtc cac aac ctc aac        480
Cys Ile Leu Pro Asn Ile Glu Ala Val Ser Asn Val His Asn Leu Asn           
145                 150                 155                 160           

tcg gtc aaa gag tca ccc cac gag cgc atg cat cgc cac atc gag ctg        528
Ser Val Lys Glu Ser Pro His Glu Arg Met His Arg His Ile Glu Leu           
                165                 170                 175               

gcc tgg gcc ttc tcc acg gtc atc ggg acg ctg ctt ttc cta gca gag        576
Ala Trp Ala Phe Ser Thr Val Ile Gly Thr Leu Leu Phe Leu Ala Glu           
            180                 185                 190                   

gtc gtg ctg ctc tgc tgg gtc aag ttc tta cct ctc aag aag cag cca        624
Val Val Leu Leu Cys Trp Val Lys Phe Leu Pro Leu Lys Lys Gln Pro           
        195                 200                 205                       

ggc cag cca agg ccc acc agc aag ccc gcc gag agt gtc ata gta gcc        672
Gly Gln Pro Arg Pro Thr Ser Lys Pro Ala Glu Ser Val Ile Val Ala           
    210                 215                 220                           

aac cac agc gac agc ggc atc acc ccg ggt gag gcg gca gcc att gcc        720
Asn His Ser Asp Ser Gly Ile Thr Pro Gly Glu Ala Ala Ala Ile Ala           
225                 230                 235                 240           

tcc acc gcc atc atg gtt ccc tgt ggc ctg gtt ttc atc gtc ttt gct        768
Ser Thr Ala Ile Met Val Pro Cys Gly Leu Val Phe Ile Val Phe Ala           
                245                 250                 255               

gtt cac ttc tac cgc tcc ctg gtc agc cat aag acg gac cgg cag ttc        816
Val His Phe Tyr Arg Ser Leu Val Ser His Lys Thr Asp Arg Gln Phe           
            260                 265                 270                   

cag gag ctc aat gag ctg gcc gag ttt gcc cgc ttg cag gac cag ctg        864
Gln Glu Leu Asn Glu Leu Ala Glu Phe Ala Arg Leu Gln Asp Gln Leu           
        275                 280                 285                       

gac cac aga ggg gac cat tct cta aca ccg ggc acc cac tat gcc taa        912
Asp His Arg Gly Asp His Ser Leu Thr Pro Gly Thr His Tyr Ala               
    290                 295                 300                           


<210>  222
<211>  303
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  222

Met His Pro Glu Pro Ala Pro Pro Pro Ser His Ser Asn Pro Glu Leu 
1               5                   10                  15      


Pro Val Ser Gly Gly Ser Ser Thr Ser Gly Ser Arg Arg Ser Arg Arg 
            20                  25                  30          


Arg Ser Gly Asp Gly Glu Pro Ser Gly Ala Pro Pro Leu Pro Pro Pro 
        35                  40                  45              


Pro Pro Ala Val Ser Tyr Pro Asp Trp Ile Gly Gln Ser Tyr Ser Glu 
    50                  55                  60                  


Val Met Ser Leu Asn Glu His Ser Met Gln Ala Leu Ser Trp Arg Lys 
65                  70                  75                  80  


Leu Tyr Leu Ser Arg Ala Lys Leu Lys Ala Ser Ser Arg Thr Ser Ala 
                85                  90                  95      


Leu Leu Ser Gly Phe Ala Met Val Ala Met Val Glu Val Gln Leu Asp 
            100                 105                 110         


Thr Asp His Asp Tyr Pro Pro Gly Leu Leu Ile Val Phe Ser Ala Cys 
        115                 120                 125             


Thr Thr Val Leu Val Ala Val His Leu Phe Ala Leu Met Ile Ser Thr 
    130                 135                 140                 


Cys Ile Leu Pro Asn Ile Glu Ala Val Ser Asn Val His Asn Leu Asn 
145                 150                 155                 160 


Ser Val Lys Glu Ser Pro His Glu Arg Met His Arg His Ile Glu Leu 
                165                 170                 175     


Ala Trp Ala Phe Ser Thr Val Ile Gly Thr Leu Leu Phe Leu Ala Glu 
            180                 185                 190         


Val Val Leu Leu Cys Trp Val Lys Phe Leu Pro Leu Lys Lys Gln Pro 
        195                 200                 205             


Gly Gln Pro Arg Pro Thr Ser Lys Pro Ala Glu Ser Val Ile Val Ala 
    210                 215                 220                 


Asn His Ser Asp Ser Gly Ile Thr Pro Gly Glu Ala Ala Ala Ile Ala 
225                 230                 235                 240 


Ser Thr Ala Ile Met Val Pro Cys Gly Leu Val Phe Ile Val Phe Ala 
                245                 250                 255     


Val His Phe Tyr Arg Ser Leu Val Ser His Lys Thr Asp Arg Gln Phe 
            260                 265                 270         


Gln Glu Leu Asn Glu Leu Ala Glu Phe Ala Arg Leu Gln Asp Gln Leu 
        275                 280                 285             


Asp His Arg Gly Asp His Ser Leu Thr Pro Gly Thr His Tyr Ala 
    290                 295                 300             


<210>  223
<211>  34
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Forward primer sequence

<400>  223
cttacctctc aagaggcagg caggccagcc aagc                                   34


<210>  224
<211>  34
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Reverse primer sequence

<400>  224
gcttggctgg cctgcctgcc tcttgagagg taag                                   34


<210>  225
<211>  912
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  mORAI1/hORAI1 ECL2 (RQAGQPSPTKPPAE) sequence


<220>
<221>  CDS
<222>  (1)..(912)

<400>  225
atg cat ccg gag cct gcc ccg ccc ccg agt cac agc aat ccg gag ctt         48
Met His Pro Glu Pro Ala Pro Pro Pro Ser His Ser Asn Pro Glu Leu           
1               5                   10                  15                

ccc gtg agc ggc ggc agc agc act agc ggc agc cgc cgg agc cgc cgc         96
Pro Val Ser Gly Gly Ser Ser Thr Ser Gly Ser Arg Arg Ser Arg Arg           
            20                  25                  30                    

cgc agc ggg gac ggg gag ccc tcg ggg gcc cca ccg ctg ccg ccg ccg        144
Arg Ser Gly Asp Gly Glu Pro Ser Gly Ala Pro Pro Leu Pro Pro Pro           
        35                  40                  45                        

cca ccc gcc gtc agc tac ccg gac tgg atc ggc cag agt tac tcc gag        192
Pro Pro Ala Val Ser Tyr Pro Asp Trp Ile Gly Gln Ser Tyr Ser Glu           
    50                  55                  60                            

gtg atg agc ctc aac gag cac tcg atg cag gcg ctg tcc tgg cgc aag        240
Val Met Ser Leu Asn Glu His Ser Met Gln Ala Leu Ser Trp Arg Lys           
65                  70                  75                  80            

ctc tac tta agc cgc gcc aag ctc aaa gct tcc agc cgg acc tcg gct        288
Leu Tyr Leu Ser Arg Ala Lys Leu Lys Ala Ser Ser Arg Thr Ser Ala           
                85                  90                  95                

ctg ctc tcc ggc ttc gcc atg gta gcg atg gtg gaa gtc cag ctg gac        336
Leu Leu Ser Gly Phe Ala Met Val Ala Met Val Glu Val Gln Leu Asp           
            100                 105                 110                   

aca gac cat gac tac cca cca ggg ttg ctc atc gtc ttt agt gcc tgc        384
Thr Asp His Asp Tyr Pro Pro Gly Leu Leu Ile Val Phe Ser Ala Cys           
        115                 120                 125                       

acc aca gtg cta gtg gcc gtg cac ctg ttt gcc ctc atg atc agc acc        432
Thr Thr Val Leu Val Ala Val His Leu Phe Ala Leu Met Ile Ser Thr           
    130                 135                 140                           

tgc atc ctg ccc aac atc gag gct gtg agc aac gtc cac aac ctc aac        480
Cys Ile Leu Pro Asn Ile Glu Ala Val Ser Asn Val His Asn Leu Asn           
145                 150                 155                 160           

tcg gtc aaa gag tca ccc cac gag cgc atg cat cgc cac atc gag ctg        528
Ser Val Lys Glu Ser Pro His Glu Arg Met His Arg His Ile Glu Leu           
                165                 170                 175               

gcc tgg gcc ttc tcc acg gtc atc ggg acg ctg ctt ttc cta gca gag        576
Ala Trp Ala Phe Ser Thr Val Ile Gly Thr Leu Leu Phe Leu Ala Glu           
            180                 185                 190                   

gtc gtg ctg ctc tgc tgg gtc aag ttc tta cct ctc aag agg cag gca        624
Val Val Leu Leu Cys Trp Val Lys Phe Leu Pro Leu Lys Arg Gln Ala           
        195                 200                 205                       

ggc cag cca agc ccc acc aag ccg ccc gcc gag agt ggc gca gca gcc        672
Gly Gln Pro Ser Pro Thr Lys Pro Pro Ala Glu Ser Gly Ala Ala Ala           
    210                 215                 220                           

aac gtc agc acc agc ggc atc acc ccg ggt gag gcg gca gcc att gcc        720
Asn Val Ser Thr Ser Gly Ile Thr Pro Gly Glu Ala Ala Ala Ile Ala           
225                 230                 235                 240           

tcc acc gcc atc atg gtt ccc tgt ggc ctg gtt ttc atc gtc ttt gct        768
Ser Thr Ala Ile Met Val Pro Cys Gly Leu Val Phe Ile Val Phe Ala           
                245                 250                 255               

gtt cac ttc tac cgc tcc ctg gtc agc cat aag acg gac cgg cag ttc        816
Val His Phe Tyr Arg Ser Leu Val Ser His Lys Thr Asp Arg Gln Phe           
            260                 265                 270                   

cag gag ctc aat gag ctg gcc gag ttt gcc cgc ttg cag gac cag ctg        864
Gln Glu Leu Asn Glu Leu Ala Glu Phe Ala Arg Leu Gln Asp Gln Leu           
        275                 280                 285                       

gac cac aga ggg gac cat tct cta aca ccg ggc acc cac tat gcc taa        912
Asp His Arg Gly Asp His Ser Leu Thr Pro Gly Thr His Tyr Ala               
    290                 295                 300                           


<210>  226
<211>  303
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  226

Met His Pro Glu Pro Ala Pro Pro Pro Ser His Ser Asn Pro Glu Leu 
1               5                   10                  15      


Pro Val Ser Gly Gly Ser Ser Thr Ser Gly Ser Arg Arg Ser Arg Arg 
            20                  25                  30          


Arg Ser Gly Asp Gly Glu Pro Ser Gly Ala Pro Pro Leu Pro Pro Pro 
        35                  40                  45              


Pro Pro Ala Val Ser Tyr Pro Asp Trp Ile Gly Gln Ser Tyr Ser Glu 
    50                  55                  60                  


Val Met Ser Leu Asn Glu His Ser Met Gln Ala Leu Ser Trp Arg Lys 
65                  70                  75                  80  


Leu Tyr Leu Ser Arg Ala Lys Leu Lys Ala Ser Ser Arg Thr Ser Ala 
                85                  90                  95      


Leu Leu Ser Gly Phe Ala Met Val Ala Met Val Glu Val Gln Leu Asp 
            100                 105                 110         


Thr Asp His Asp Tyr Pro Pro Gly Leu Leu Ile Val Phe Ser Ala Cys 
        115                 120                 125             


Thr Thr Val Leu Val Ala Val His Leu Phe Ala Leu Met Ile Ser Thr 
    130                 135                 140                 


Cys Ile Leu Pro Asn Ile Glu Ala Val Ser Asn Val His Asn Leu Asn 
145                 150                 155                 160 


Ser Val Lys Glu Ser Pro His Glu Arg Met His Arg His Ile Glu Leu 
                165                 170                 175     


Ala Trp Ala Phe Ser Thr Val Ile Gly Thr Leu Leu Phe Leu Ala Glu 
            180                 185                 190         


Val Val Leu Leu Cys Trp Val Lys Phe Leu Pro Leu Lys Arg Gln Ala 
        195                 200                 205             


Gly Gln Pro Ser Pro Thr Lys Pro Pro Ala Glu Ser Gly Ala Ala Ala 
    210                 215                 220                 


Asn Val Ser Thr Ser Gly Ile Thr Pro Gly Glu Ala Ala Ala Ile Ala 
225                 230                 235                 240 


Ser Thr Ala Ile Met Val Pro Cys Gly Leu Val Phe Ile Val Phe Ala 
                245                 250                 255     


Val His Phe Tyr Arg Ser Leu Val Ser His Lys Thr Asp Arg Gln Phe 
            260                 265                 270         


Gln Glu Leu Asn Glu Leu Ala Glu Phe Ala Arg Leu Gln Asp Gln Leu 
        275                 280                 285             


Asp His Arg Gly Asp His Ser Leu Thr Pro Gly Thr His Tyr Ala 
    290                 295                 300             


<210>  227
<211>  42
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Forward primer sequence

<400>  227
gtgtcatagt agccaaccac agcgacagcg gcatcacccc gg                          42


<210>  228
<211>  42
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Reverse primer sequence

<400>  228
ccggggtgat gccgctgtcg ctgtggttgg ctactatgac ac                          42


<210>  229
<211>  17
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<223>  210 to 226 of SEQ ID NO:2

<400>  229

Arg Pro Thr Ser Lys Pro Pro Ala Ser Gly Ala Ala Ala Asn Val Ser 
1               5                   10                  15      


Thr 
    


<210>  230
<211>  17
<212>  PRT
<213>  Mus musculus


<220>
<221>  MISC_FEATURE
<223>  212 to 228 of SEQ ID NO:72

<400>  230

Ser Pro Thr Lys Pro Pro Ala Glu Ser Val Ile Val Ala Asn His Ser 
1               5                   10                  15      


Asp 
    


<210>  231
<211>  912
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  mORAI1/hORAI1 ECL2 (SPTKPPAESVIVANHSD) sequence


<220>
<221>  CDS
<222>  (1)..(912)

<400>  231
atg cat ccg gag cct gcc ccg ccc ccg agt cac agc aat ccg gag ctt         48
Met His Pro Glu Pro Ala Pro Pro Pro Ser His Ser Asn Pro Glu Leu           
1               5                   10                  15                

ccc gtg agc ggc ggc agc agc act agc ggc agc cgc cgg agc cgc cgc         96
Pro Val Ser Gly Gly Ser Ser Thr Ser Gly Ser Arg Arg Ser Arg Arg           
            20                  25                  30                    

cgc agc ggg gac ggg gag ccc tcg ggg gcc cca ccg ctg ccg ccg ccg        144
Arg Ser Gly Asp Gly Glu Pro Ser Gly Ala Pro Pro Leu Pro Pro Pro           
        35                  40                  45                        

cca ccc gcc gtc agc tac ccg gac tgg atc ggc cag agt tac tcc gag        192
Pro Pro Ala Val Ser Tyr Pro Asp Trp Ile Gly Gln Ser Tyr Ser Glu           
    50                  55                  60                            

gtg atg agc ctc aac gag cac tcg atg cag gcg ctg tcc tgg cgc aag        240
Val Met Ser Leu Asn Glu His Ser Met Gln Ala Leu Ser Trp Arg Lys           
65                  70                  75                  80            

ctc tac tta agc cgc gcc aag ctc aaa gct tcc agc cgg acc tcg gct        288
Leu Tyr Leu Ser Arg Ala Lys Leu Lys Ala Ser Ser Arg Thr Ser Ala           
                85                  90                  95                

ctg ctc tcc ggc ttc gcc atg gta gcg atg gtg gaa gtc cag ctg gac        336
Leu Leu Ser Gly Phe Ala Met Val Ala Met Val Glu Val Gln Leu Asp           
            100                 105                 110                   

aca gac cat gac tac cca cca ggg ttg ctc atc gtc ttt agt gcc tgc        384
Thr Asp His Asp Tyr Pro Pro Gly Leu Leu Ile Val Phe Ser Ala Cys           
        115                 120                 125                       

acc aca gtg cta gtg gcc gtg cac ctg ttt gcc ctc atg atc agc acc        432
Thr Thr Val Leu Val Ala Val His Leu Phe Ala Leu Met Ile Ser Thr           
    130                 135                 140                           

tgc atc ctg ccc aac atc gag gct gtg agc aac gtc cac aac ctc aac        480
Cys Ile Leu Pro Asn Ile Glu Ala Val Ser Asn Val His Asn Leu Asn           
145                 150                 155                 160           

tcg gtc aaa gag tca ccc cac gag cgc atg cat cgc cac atc gag ctg        528
Ser Val Lys Glu Ser Pro His Glu Arg Met His Arg His Ile Glu Leu           
                165                 170                 175               

gcc tgg gcc ttc tcc acg gtc atc ggg acg ctg ctt ttc cta gca gag        576
Ala Trp Ala Phe Ser Thr Val Ile Gly Thr Leu Leu Phe Leu Ala Glu           
            180                 185                 190                   

gtc gtg ctg ctc tgc tgg gtc aag ttc tta cct ctc aag aag cag cca        624
Val Val Leu Leu Cys Trp Val Lys Phe Leu Pro Leu Lys Lys Gln Pro           
        195                 200                 205                       

ggc cag cca agc ccc acc aag ccg ccc gcc gag agt gtc ata gta gcc        672
Gly Gln Pro Ser Pro Thr Lys Pro Pro Ala Glu Ser Val Ile Val Ala           
    210                 215                 220                           

aac cac agc gac agc ggc atc acc ccg ggt gag gcg gca gcc att gcc        720
Asn His Ser Asp Ser Gly Ile Thr Pro Gly Glu Ala Ala Ala Ile Ala           
225                 230                 235                 240           

tcc acc gcc atc atg gtt ccc tgt ggc ctg gtt ttc atc gtc ttt gct        768
Ser Thr Ala Ile Met Val Pro Cys Gly Leu Val Phe Ile Val Phe Ala           
                245                 250                 255               

gtt cac ttc tac cgc tcc ctg gtc agc cat aag acg gac cgg cag ttc        816
Val His Phe Tyr Arg Ser Leu Val Ser His Lys Thr Asp Arg Gln Phe           
            260                 265                 270                   

cag gag ctc aat gag ctg gcc gag ttt gcc cgc ttg cag gac cag ctg        864
Gln Glu Leu Asn Glu Leu Ala Glu Phe Ala Arg Leu Gln Asp Gln Leu           
        275                 280                 285                       

gac cac aga ggg gac cat tct cta aca ccg ggc acc cac tat gcc taa        912
Asp His Arg Gly Asp His Ser Leu Thr Pro Gly Thr His Tyr Ala               
    290                 295                 300                           


<210>  232
<211>  303
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  232

Met His Pro Glu Pro Ala Pro Pro Pro Ser His Ser Asn Pro Glu Leu 
1               5                   10                  15      


Pro Val Ser Gly Gly Ser Ser Thr Ser Gly Ser Arg Arg Ser Arg Arg 
            20                  25                  30          


Arg Ser Gly Asp Gly Glu Pro Ser Gly Ala Pro Pro Leu Pro Pro Pro 
        35                  40                  45              


Pro Pro Ala Val Ser Tyr Pro Asp Trp Ile Gly Gln Ser Tyr Ser Glu 
    50                  55                  60                  


Val Met Ser Leu Asn Glu His Ser Met Gln Ala Leu Ser Trp Arg Lys 
65                  70                  75                  80  


Leu Tyr Leu Ser Arg Ala Lys Leu Lys Ala Ser Ser Arg Thr Ser Ala 
                85                  90                  95      


Leu Leu Ser Gly Phe Ala Met Val Ala Met Val Glu Val Gln Leu Asp 
            100                 105                 110         


Thr Asp His Asp Tyr Pro Pro Gly Leu Leu Ile Val Phe Ser Ala Cys 
        115                 120                 125             


Thr Thr Val Leu Val Ala Val His Leu Phe Ala Leu Met Ile Ser Thr 
    130                 135                 140                 


Cys Ile Leu Pro Asn Ile Glu Ala Val Ser Asn Val His Asn Leu Asn 
145                 150                 155                 160 


Ser Val Lys Glu Ser Pro His Glu Arg Met His Arg His Ile Glu Leu 
                165                 170                 175     


Ala Trp Ala Phe Ser Thr Val Ile Gly Thr Leu Leu Phe Leu Ala Glu 
            180                 185                 190         


Val Val Leu Leu Cys Trp Val Lys Phe Leu Pro Leu Lys Lys Gln Pro 
        195                 200                 205             


Gly Gln Pro Ser Pro Thr Lys Pro Pro Ala Glu Ser Val Ile Val Ala 
    210                 215                 220                 


Asn His Ser Asp Ser Gly Ile Thr Pro Gly Glu Ala Ala Ala Ile Ala 
225                 230                 235                 240 


Ser Thr Ala Ile Met Val Pro Cys Gly Leu Val Phe Ile Val Phe Ala 
                245                 250                 255     


Val His Phe Tyr Arg Ser Leu Val Ser His Lys Thr Asp Arg Gln Phe 
            260                 265                 270         


Gln Glu Leu Asn Glu Leu Ala Glu Phe Ala Arg Leu Gln Asp Gln Leu 
        275                 280                 285             


Asp His Arg Gly Asp His Ser Leu Thr Pro Gly Thr His Tyr Ala 
    290                 295                 300             


<210>  233
<211>  66
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  VK-1 signal peptide coding sequence


<220>
<221>  CDS
<222>  (1)..(66)

<400>  233
atg gac atg agg gtg ccc gct cag ctc ctg ggg ctc ctg ctg ctg tgg         48
Met Asp Met Arg Val Pro Ala Gln Leu Leu Gly Leu Leu Leu Leu Trp           
1               5                   10                  15                

ctg aga ggt gcg cgc tgt                                                 66
Leu Arg Gly Ala Arg Cys                                                   
            20                                                            


<210>  234
<211>  22
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  234

Met Asp Met Arg Val Pro Ala Gln Leu Leu Gly Leu Leu Leu Leu Trp 
1               5                   10                  15      


Leu Arg Gly Ala Arg Cys 
            20          


<210>  235
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Integrin-binding peptide

<400>  235

Cys Tyr Gly Gly Arg Gly Asp Thr Pro 
1               5                   


<210>  236
<211>  72
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Forward primer sequence

<400>  236
ctgctcttcc tagctgaggt ggtgctgctc tgctgggtca agttcttgcc cctcaagagg       60

caagcgggac ag                                                           72


<210>  237
<211>  67
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Forward primer sequence

<400>  237
ctcaagaggc aagcgggaca gccaagcccc accaagcctc ccgctgaatc agtcatcgtc       60

gccaacc                                                                 67


<210>  238
<211>  68
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Forward primer sequence

<400>  238
gaatcagtca tcgtcgccaa ccacagcgac agcagcggca tcaccccggg ccaggcagct       60

gccatcgc                                                                68


<210>  239
<211>  66
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Reverse primer sequence

<400>  239
gagcggtaga agtgaacagc aaagacgata aaaaccaggc cacagggaac catgatggcg       60

gtggag                                                                  66


<210>  240
<211>  66
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Reverse primer sequence

<400>  240
ctcattgagc tcctggaact gccggtccgt cttatggctg accagggagc ggtagaagtg       60

aacagc                                                                  66


<210>  241
<211>  65
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Reverse primer sequence

<400>  241
ctctgtggtc cagctggtcc tgcaagcggg caaactcggc cagctcattg agctcctgga       60

actgc                                                                   65


<210>  242
<211>  70
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Reverse primer sequence

<400>  242
cgcggccgct taggcatagt gggtgcccgg tgttagagaa tggtcccctc tgtggtccag       60

ctggtcctgc                                                              70


<210>  243
<211>  330
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<223>  hIgG1z sequence

<400>  243

Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys 
1               5                   10                  15      


Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr 
65                  70                  75                  80  


Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      


Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys 
            100                 105                 110         


Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro 
        115                 120                 125             


Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 
    130                 135                 140                 


Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp 
145                 150                 155                 160 


Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 
                165                 170                 175     


Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 
            180                 185                 190         


His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 
        195                 200                 205             


Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 
    210                 215                 220                 


Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu 
225                 230                 235                 240 


Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr 
                245                 250                 255     


Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 
            260                 265                 270         


Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 
        275                 280                 285             


Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn 
    290                 295                 300                 


Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 
305                 310                 315                 320 


Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
                325                 330 


<210>  244
<211>  330
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<223>  hIgG1za sequence

<400>  244

Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys 
1               5                   10                  15      


Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr 
65                  70                  75                  80  


Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      


Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys 
            100                 105                 110         


Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro 
        115                 120                 125             


Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 
    130                 135                 140                 


Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp 
145                 150                 155                 160 


Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 
                165                 170                 175     


Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 
            180                 185                 190         


His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 
        195                 200                 205             


Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 
    210                 215                 220                 


Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu 
225                 230                 235                 240 


Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr 
                245                 250                 255     


Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 
            260                 265                 270         


Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 
        275                 280                 285             


Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn 
    290                 295                 300                 


Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 
305                 310                 315                 320 


Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
                325                 330 


<210>  245
<211>  330
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<223>  hIgG1f sequence

<400>  245

Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys 
1               5                   10                  15      


Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr 
65                  70                  75                  80  


Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      


Arg Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys 
            100                 105                 110         


Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro 
        115                 120                 125             


Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 
    130                 135                 140                 


Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp 
145                 150                 155                 160 


Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 
                165                 170                 175     


Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 
            180                 185                 190         


His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 
        195                 200                 205             


Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 
    210                 215                 220                 


Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu 
225                 230                 235                 240 


Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr 
                245                 250                 255     


Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 
            260                 265                 270         


Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 
        275                 280                 285             


Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn 
    290                 295                 300                 


Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 
305                 310                 315                 320 


Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
                325                 330 


<210>  246
<211>  330
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<223>  hIgG1fa sequence

<400>  246

Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys 
1               5                   10                  15      


Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr 
65                  70                  75                  80  


Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      


Arg Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys 
            100                 105                 110         


Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro 
        115                 120                 125             


Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 
    130                 135                 140                 


Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp 
145                 150                 155                 160 


Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 
                165                 170                 175     


Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 
            180                 185                 190         


His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 
        195                 200                 205             


Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 
    210                 215                 220                 


Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu 
225                 230                 235                 240 


Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr 
                245                 250                 255     


Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 
            260                 265                 270         


Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 
        275                 280                 285             


Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn 
    290                 295                 300                 


Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 
305                 310                 315                 320 


Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
                325                 330 


<210>  247
<211>  106
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<223>  CL-2 human LC constant domain

<400>  247

Gly Gln Pro Lys Ala Ala Pro Ser Val Thr Leu Phe Pro Pro Ser Ser 
1               5                   10                  15      


Glu Glu Leu Gln Ala Asn Lys Ala Thr Leu Val Cys Leu Ile Ser Asp 
            20                  25                  30          


Phe Tyr Pro Gly Ala Val Thr Val Ala Trp Lys Ala Asp Ser Ser Pro 
        35                  40                  45              


Val Lys Ala Gly Val Glu Thr Thr Thr Pro Ser Lys Gln Ser Asn Asn 
    50                  55                  60                  


Lys Tyr Ala Ala Ser Ser Tyr Leu Ser Leu Thr Pro Glu Gln Trp Lys 
65                  70                  75                  80  


Ser His Arg Ser Tyr Ser Cys Gln Val Thr His Glu Gly Ser Thr Val 
                85                  90                  95      


Glu Lys Thr Val Ala Pro Thr Glu Cys Ser 
            100                 105     


<210>  248
<211>  106
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<223>  CL-3 human LC constant domain

<400>  248

Gly Gln Pro Lys Ala Ala Pro Ser Val Thr Leu Phe Pro Pro Ser Ser 
1               5                   10                  15      


Glu Glu Leu Gln Ala Asn Lys Ala Thr Leu Val Cys Leu Ile Ser Asp 
            20                  25                  30          


Phe Tyr Pro Gly Ala Val Thr Val Ala Trp Lys Ala Asp Ser Ser Pro 
        35                  40                  45              


Val Lys Ala Gly Val Glu Thr Thr Thr Pro Ser Lys Gln Ser Asn Asn 
    50                  55                  60                  


Lys Tyr Ala Ala Ser Ser Tyr Leu Ser Leu Thr Pro Glu Gln Trp Lys 
65                  70                  75                  80  


Ser His Lys Ser Tyr Ser Cys Gln Val Thr His Glu Gly Ser Thr Val 
                85                  90                  95      


Glu Lys Thr Val Ala Pro Thr Glu Cys Ser 
            100                 105     


<210>  249
<211>  106
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<223>  CL-7 human LC constant domain

<400>  249

Gly Gln Pro Lys Ala Ala Pro Ser Val Thr Leu Phe Pro Pro Ser Ser 
1               5                   10                  15      


Glu Glu Leu Gln Ala Asn Lys Ala Thr Leu Val Cys Leu Val Ser Asp 
            20                  25                  30          


Phe Tyr Pro Gly Ala Val Thr Val Ala Trp Lys Ala Asp Gly Ser Pro 
        35                  40                  45              


Val Lys Val Gly Val Glu Thr Thr Lys Pro Ser Lys Gln Ser Asn Asn 
    50                  55                  60                  


Lys Tyr Ala Ala Ser Ser Tyr Leu Ser Leu Thr Pro Glu Gln Trp Lys 
65                  70                  75                  80  


Ser His Arg Ser Tyr Ser Cys Arg Val Thr His Glu Gly Ser Thr Val 
                85                  90                  95      


Glu Lys Thr Val Ala Pro Ala Glu Cys Ser 
            100                 105     


<210>  250
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH5

<400>  250

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Pro Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asp Tyr 
            20                  25                  30          


Tyr Ile Asn Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Asn Pro Asn Asn Gly Gly Thr Asn Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Met Thr Arg Asp Thr Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Arg Arg Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Glu Arg Gly Gly Tyr Glu Asp Trp Phe Asp Pro Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser 
        115                 120 


<210>  251
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH6

<400>  251

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asp Tyr 
            20                  25                  30          


Tyr Ile Asn Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Asn Pro Asn Ser Gly Gly Ser Ser Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Met Thr Arg Asp Thr Ser Ile Ser Thr Ala His 
65                  70                  75                  80  


Met Glu Leu Ile Arg Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Glu Arg Gly Gly Ile Glu Asp Trp Phe Asp Pro Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser 
        115                 120 


<210>  252
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH7

<400>  252

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asp Tyr 
            20                  25                  30          


Tyr Ile Asn Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Asn Pro Asn Ser Gly Gly Thr Asp Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Met Thr Arg Asp Thr Ser Ile Arg Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Asn Arg Leu Thr Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Glu Tyr Gly Gly Tyr Glu Asp Trp Phe Asp Pro Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser 
        115                 120 


<210>  253
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH8

<400>  253

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asp Tyr 
            20                  25                  30          


Tyr Met Asn Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Asn Pro Asn Ser Gly Gly Thr His Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Met Thr Arg Asp Thr Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Arg Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Glu Tyr Gly Gly Tyr Ser Asp Trp Phe Asp Pro Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser 
        115                 120 


<210>  254
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH9

<400>  254

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asp Tyr 
            20                  25                  30          


Tyr Met Asn Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Asn Pro Asn Ser Gly Gly Thr Lys Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Met Thr Arg Asp Thr Ser Ile Arg Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Arg Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Glu Tyr Gly Gly Asn Ser Asp Trp Phe Asp Pro Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser 
        115                 120 


<210>  255
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH10

<400>  255

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asp Tyr 
            20                  25                  30          


Tyr Met Asn Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Asn Pro Asn Ser Gly Gly Thr Lys Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Met Thr Arg Asp Thr Ser Ile Arg Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Arg Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ser Arg Glu Tyr Gly Gly Asn Ser Asp Trp Phe Asp Pro Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser 
        115                 120 


<210>  256
<211>  109
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL4

<400>  256

Gln Ser Val Leu Thr Gln Pro Pro Ser Val Ser Gly Ala Pro Gly Gln 
1               5                   10                  15      


Arg Val Thr Ile Ser Cys Thr Gly Ser Ser Ser Asn Ile Gly Ala Gly 
            20                  25                  30          


Phe Asp Val His Trp Tyr Gln Gln Leu Pro Val Thr Ala Pro Lys Leu 
        35                  40                  45              


Leu Ile Tyr Gly Asn Arg Asn Arg Pro Ser Gly Val Pro Ala Arg Phe 
    50                  55                  60                  


Ser Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Thr Gly Leu 
65                  70                  75                  80  


Gln Ala Glu Asp Glu Ala Val Tyr Tyr Cys Gln Ser Tyr Asp Ser Ser 
                85                  90                  95      


Leu Thr Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 


<210>  257
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL5

<400>  257

Gln Ser Val Leu Thr Gln Pro Pro Ser Val Ser Gly Ala Pro Gly Gln 
1               5                   10                  15      


Arg Val Thr Ile Ser Cys Thr Gly Ser Ser Ser Asn Ile Gly Ala Gly 
            20                  25                  30          


Tyr Asp Val His Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu 
        35                  40                  45              


Leu Ile Tyr Gly Asn Ser Asn Arg Pro Ser Gly Val Pro Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Thr Lys Phe 
65                  70                  75                  80  


Gln Ala Glu Asp Glu Ala Val Tyr Tyr Cys Gln Ser Tyr Gly Ser Gly 
                85                  90                  95      


Leu Ser Gly Val Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 110     


<210>  258
<211>  109
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL6

<400>  258

Ser Cys Glu Leu Thr Gln Ser Pro Ser Val Ser Val Ser Pro Gly Gln 
1               5                   10                  15      


Thr Ala Arg Ile Thr Cys Ser Gly Asp Ala Leu Pro Lys Lys Tyr Ala 
            20                  25                  30          


Cys Cys Tyr Gln Gln Lys Ser Gly Gln Ala Pro Val Leu Val Val Tyr 
        35                  40                  45              


Asp Asp His Lys Arg Pro Ser Gly Ile Pro Glu Arg Phe Ser Gly Ser 
    50                  55                  60                  


Ser Ser Gly Thr Leu Ala Thr Leu Ile Ile Ser Gly Ala Gln Val Glu 
65                  70                  75                  80  


Asp Glu Ala Asp Ser Tyr Cys Tyr Ser Thr Asp Ser Ser Gly Asn His 
                85                  90                  95      


Ser Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 


<210>  259
<211>  109
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL7

<400>  259

Gln Ser Val Leu Thr Gln Pro Pro Ser Val Ser Gly Ala Pro Gly Gln 
1               5                   10                  15      


Arg Val Thr Ile Ser Cys Thr Gly Ser Asn Ser Asn Ile Gly Ala Gly 
            20                  25                  30          


Phe Asp Val His Trp Tyr Gln Gln Leu Pro Gly Thr Val Pro Lys Leu 
        35                  40                  45              


Leu Ile Tyr Gly Asn Asn Asn Arg Pro Ser Gly Val Pro Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Thr Gly Leu 
65                  70                  75                  80  


Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Gln Ser Tyr Asp Ser Arg 
                85                  90                  95      


Leu Thr Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 


<210>  260
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL8

<400>  260

Gln Ser Val Leu Thr Gln Pro Pro Ser Val Ser Gly Ala Pro Gly Gln 
1               5                   10                  15      


Arg Val Thr Ile Ser Cys Thr Gly Ser Arg Ser Asn Ile Gly Ala Gly 
            20                  25                  30          


Tyr Asp Val His Trp Tyr Gln Gln Leu Pro Arg Thr Ala Pro Lys Leu 
        35                  40                  45              


Leu Ile Tyr Asp Asn Ser Asn Arg Pro Ser Gly Val Pro Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Lys Ser Gly Ser Ser Ala Ser Leu Ala Ile Thr Gly Leu 
65                  70                  75                  80  


Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Gln Ser Tyr Asp Asn Ser 
                85                  90                  95      


Leu Ser Asp Ser Val Leu Ile Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 110         


<210>  261
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL9

<400>  261

Gln Ser Ala Leu Thr Gln Pro Pro Ser Ala Ser Gly Ser Pro Gly Gln 
1               5                   10                  15      


Ser Val Thr Ser Ser Cys Thr Gly Thr Ser Ser Asp Val Gly Gly Tyr 
            20                  25                  30          


Asn Tyr Val Ser Trp Tyr Gln Gln His Pro Gly Lys Ala Pro Lys Leu 
        35                  40                  45              


Met Ile Tyr Glu Val Ser Lys Arg Pro Ser Gly Val Pro Asp Trp Phe 
    50                  55                  60                  


Ser Gly Ser Lys Ser Gly Asn Thr Ala Ser Leu Thr Val Ser Gly Leu 
65                  70                  75                  80  


Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Tyr Asn Ser Tyr Ser Gly Ser 
                85                  90                  95      


Asn Asn Phe Asp Val Phe Gly Thr Gly Thr Lys Val Thr Val Leu 
            100                 105                 110     


<210>  262
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL10

<400>  262

Gln Ser Val Leu Thr Gln Pro Pro Ser Val Ser Gly Ala Pro Gly Gln 
1               5                   10                  15      


Arg Val Thr Ile Ser Cys Thr Gly Ser Ser Ser Asn Ile Gly Ala Gly 
            20                  25                  30          


Tyr Asp Val His Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu 
        35                  40                  45              


Leu Ile Tyr Gly Asn Ser Asn Arg Pro Ser Gly Val Pro Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Thr Gly Leu 
65                  70                  75                  80  


Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Gln Ser Tyr Asp Asn Arg 
                85                  90                  95      


Leu Ser Asp Ser Val Val Ile Gly Gly Gly Thr Lys Leu Ala Val Gln 
            100                 105                 110         


<210>  263
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL11

<400>  263

Gln Ser Ala Leu Thr Gln Pro Pro Ser Ala Ser Gly Ser Pro Gly Gln 
1               5                   10                  15      


Ser Val Thr Ser Ser Cys Thr Gly Thr Ser Ser Asp Val Gly Gly Tyr 
            20                  25                  30          


Asn Tyr Val Ser Trp Tyr Gln Gln Gln Pro Gly Lys Ala Pro Lys Leu 
        35                  40                  45              


Met Ile Tyr Glu Val Ser Lys Arg Pro Ser Gly Val Pro Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Lys Ser Gly Asn Thr Ala Ser Leu Thr Val Ser Gly Leu 
65                  70                  75                  80  


Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Phe Ser Ser Tyr Ala Gly Ser 
                85                  90                  95      


Asn Asn Phe Asp Val Phe Gly Thr Gly Thr Lys Val Thr Val Leu 
            100                 105                 110     


<210>  264
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL12

<400>  264

Gln Ser Val Leu Thr Gln Pro Pro Ser Val Ser Gly Ala Pro Gly Gln 
1               5                   10                  15      


Arg Val Thr Ile Ser Cys Thr Gly Ser Ser Ser Asn Ile Gly Ala Gly 
            20                  25                  30          


Tyr Asp Val His Trp Tyr Gln Gln Ser Pro Gly Thr Ala Pro Lys Leu 
        35                  40                  45              


Leu Ile Tyr Gly Asn Ser Asn Arg Pro Ser Gly Val Pro Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Thr Gly Leu 
65                  70                  75                  80  


Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Gln Ser Tyr Asp Asn Arg 
                85                  90                  95      


Leu Ser Asp Ser Val Val Ile Gly Gly Gly Thr Lys Leu Thr Val Gln 
            100                 105                 110         


<210>  265
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL13

<400>  265

Gln Ser Val Leu Thr Gln Pro Pro Ser Val Ser Gly Ala Pro Gly Gln 
1               5                   10                  15      


Arg Val Thr Ile Ser Cys Thr Gly Ser Ser Ser Asn Ile Gly Ala Gly 
            20                  25                  30          


Tyr Asp Val His Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu 
        35                  40                  45              


Leu Ile Tyr Gly Asn Ser Asn Arg Pro Ser Gly Val Pro Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Thr Gly Leu 
65                  70                  75                  80  


Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Gln Ser Tyr Asp Asn Arg 
                85                  90                  95      


Leu Ser Asp Ser Val Val Ile Gly Gly Gly Thr Lys Leu Thr Val Gln 
            100                 105                 110         


<210>  266
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRH1-4

<400>  266

Asp Tyr Tyr Ile Asn 
1               5   


<210>  267
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRH1-5

<400>  267

Asp Tyr Tyr Met Asn 
1               5   


<210>  268
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRH2-5

<400>  268

Trp Ile Asn Pro Asn Asn Gly Gly Thr Asn Tyr Ala Gln Lys Phe Gln 
1               5                   10                  15      


Gly 
    


<210>  269
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRH2-6

<400>  269

Trp Ile Asn Pro Asn Ser Gly Gly Ser Ser Tyr Ala Gln Lys Phe Gln 
1               5                   10                  15      


Gly 
    


<210>  270
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRH2-7

<400>  270

Trp Ile Asn Pro Asn Ser Gly Gly Thr Asp Tyr Ala Gln Lys Phe Gln 
1               5                   10                  15      


Gly 
    


<210>  271
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRH2-8

<400>  271

Trp Ile Asn Pro Asn Ser Gly Gly Thr His Tyr Ala Gln Lys Phe Gln 
1               5                   10                  15      


Gly 
    


<210>  272
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRH2-9

<400>  272

Trp Ile Asn Pro Asn Ser Gly Gly Thr Lys Tyr Ala Gln Lys Phe Gln 
1               5                   10                  15      


Gly 
    


<210>  273
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRH3-4

<400>  273

Glu Arg Gly Gly Tyr Glu Asp Trp Phe Asp Pro 
1               5                   10      


<210>  274
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRH3-5

<400>  274

Glu Arg Gly Gly Ile Glu Asp Trp Phe Asp Pro 
1               5                   10      


<210>  275
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRH3-6

<400>  275

Glu Tyr Gly Gly Tyr Glu Asp Trp Phe Asp Pro 
1               5                   10      


<210>  276
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRH3-7

<400>  276

Glu Tyr Gly Gly Tyr Ser Asp Trp Phe Asp Pro 
1               5                   10      


<210>  277
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRH3-8

<400>  277

Glu Tyr Gly Gly Asn Ser Asp Trp Phe Asp Pro 
1               5                   10      


<210>  278
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRL1-4

<400>  278

Thr Gly Ser Ser Ser Asn Ile Gly Ala Gly Phe Asp Val His 
1               5                   10                  


<210>  279
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRL1-5

<400>  279

Thr Gly Ser Ser Ser Asn Ile Gly Ala Gly Tyr Asp Val His 
1               5                   10                  


<210>  280
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRL1-6

<400>  280

Ser Gly Asp Ala Leu Pro Lys Lys Tyr Ala Cys 
1               5                   10      


<210>  281
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRL1-7

<400>  281

Thr Gly Ser Asn Ser Asn Ile Gly Ala Gly Phe Asp Val His 
1               5                   10                  


<210>  282
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRL1-8

<400>  282

Thr Gly Ser Arg Ser Asn Ile Gly Ala Gly Tyr Asp Val His 
1               5                   10                  


<210>  283
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRL1-9

<400>  283

Thr Gly Thr Ser Ser Asp Val Gly Gly Tyr Asn Tyr Val Ser 
1               5                   10                  


<210>  284
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRL2-3

<400>  284

Gly Asn Arg Asn Arg Pro Ser 
1               5           


<210>  285
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRL2-4

<400>  285

Gly Asn Ser Asn Arg Pro Ser 
1               5           


<210>  286
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRL2-5

<400>  286

Asp Asp His Lys Arg Pro Ser 
1               5           


<210>  287
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRL2-6

<400>  287

Gly Asn Asn Asn Arg Pro Ser 
1               5           


<210>  288
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRL2-7

<400>  288

Asp Asn Ser Asn Arg Pro Ser 
1               5           


<210>  289
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRL2-8

<400>  289

Glu Val Ser Lys Arg Pro Ser 
1               5           


<210>  290
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRL3-3

<400>  290

Gln Ser Tyr Asp Ser Ser Leu Thr Val 
1               5                   


<210>  291
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRL3-4

<400>  291

Gln Ser Tyr Gly Ser Gly Leu Ser Gly Val Val 
1               5                   10      


<210>  292
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRL3-5

<400>  292

Tyr Ser Thr Asp Ser Ser Gly Asn His Ser Trp Val 
1               5                   10          


<210>  293
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRL3-6

<400>  293

Gln Ser Tyr Asp Ser Arg Leu Thr Val 
1               5                   


<210>  294
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRL3-7

<400>  294

Gln Ser Tyr Asp Asn Ser Leu Ser Asp Ser Val Leu 
1               5                   10          


<210>  295
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRL3-8

<400>  295

Asn Ser Tyr Ser Gly Ser Asn Asn Phe Asp Val 
1               5                   10      


<210>  296
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRL3-9

<400>  296

Gln Ser Tyr Asp Asn Arg Leu Ser Asp Ser Val Val 
1               5                   10          


<210>  297
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRL3-10

<400>  297

Ser Ser Tyr Ala Gly Ser Asn Asn Phe Asp Val 
1               5                   10      


<210>  298
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRH1


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Xaa in position 1 is a glycine, serine or aspartate residue

<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  Xaa in position 3 is a tyrosine or tryptophan residue

<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  Xaa in position 4 is a tryptophan, methionine, or isoleucine 
       residue

<220>
<221>  MISC_FEATURE
<222>  (5)..(5)
<223>  Xaa in position 5 is a serine, histidine, or asparagine residue

<400>  298

Xaa Tyr Xaa Xaa Xaa 
1               5   


<210>  299
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRH2


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Xaa in position 1 is a tryptophan, glutamate, or asparagine 
       residue

<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  Xaa in position 1 is an asparagine, aspartate, or lysine residue

<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  Xaa in position 4 is a proline or histidine residue

<220>
<221>  MISC_FEATURE
<222>  (5)..(5)
<223>  Xaa in position 5 is an asparagine, aspartate, or serine residue

<220>
<221>  MISC_FEATURE
<222>  (6)..(6)
<223>  Xaa in position 6 is an asparagine, serine, or glycine residue

<220>
<221>  MISC_FEATURE
<222>  (7)..(7)
<223>  Xaa in position 7 is a glycine, serine, or arginine residue

<220>
<221>  MISC_FEATURE
<222>  (8)..(8)
<223>  Xaa in position 8 is a glycine, threonine, isoleucine, or 
       glutamate residue

<220>
<221>  MISC_FEATURE
<222>  (9)..(9)
<223>  Xaa in position 9 is a threonine, serine, asparagine, or lysine 
       residue

<220>
<221>  MISC_FEATURE
<222>  (10)..(10)
<223>  Xaa in position 10 is a tyrosine, serine, asparagine, aspartate, 
       histidine, or lysine residue

<220>
<221>  MISC_FEATURE
<222>  (11)..(11)
<223>  Xaa in position 11 is a tyrosine or asparagine residue

<220>
<221>  MISC_FEATURE
<222>  (12)..(12)
<223>  Xaa in position 12 is an alanine, valine, or proline residue

<220>
<221>  MISC_FEATURE
<222>  (13)..(13)
<223>  Xaa in position 13 is a glutamine, alanine, or aspartate residue

<220>
<221>  MISC_FEATURE
<222>  (14)..(14)
<223>  Xaa in position 14 is a lysine, leucine, or serine residue

<220>
<221>  MISC_FEATURE
<222>  (15)..(15)
<223>  Xaa in position 15 is a phenylalanine, lysine, or valine residue

<220>
<221>  MISC_FEATURE
<222>  (16)..(16)
<223>  Xaa in position 16 is a glutamine, serine, or lysine residue

<220>
<221>  MISC_FEATURE
<222>  (17)..(17)
<223>  Xaa in position 17 is a glycine or aspartate residue, or absent

<400>  299

Xaa Ile Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
1               5                   10                  15      


Xaa 
    


<210>  300
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRH3


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Xaa in position 1 is an alanine or arginine residue, or absent

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa in position 2 is a glutamate, glycine, or tyrosine residue

<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  Xaa in position 3 is a glutamate, serine, arginine, or tyrosine 
       residue

<220>
<221>  MISC_FEATURE
<222>  (5)..(5)
<223>  Xaa in position 5 is a glycine or aspartate residue

<220>
<221>  MISC_FEATURE
<222>  (6)..(6)
<223>  Xaa in position 6 is a tyrosine, tryptophan, isoleucine, or 
       asparagine residue

<220>
<221>  MISC_FEATURE
<222>  (7)..(7)
<223>  Xaa in position 7 is a glutamate, serine, or glycine residue, or 
       absent

<220>
<221>  MISC_FEATURE
<222>  (8)..(8)
<223>  Xaa in position 8 is a methionine residue, or absent

<220>
<221>  MISC_FEATURE
<222>  (9)..(9)
<223>  Xaa in position 9 is a threonine or aspartate residue

<220>
<221>  MISC_FEATURE
<222>  (10)..(10)
<223>  Xaa in position 10 is a phenylalanine, tryptophan, or valine 
       residue

<220>
<221>  MISC_FEATURE
<222>  (11)..(11)
<223>  Xaa in position 11 is a phenylalanine residue, or absent

<220>
<221>  MISC_FEATURE
<222>  (12)..(12)
<223>  Xaa in position 12 is an aspartate residue, or absent

<220>
<221>  MISC_FEATURE
<222>  (13)..(13)
<223>  Xaa in position 13 is a proline or tyrosine residue, or absent

<400>  300

Xaa Xaa Xaa Gly Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
1               5                   10              


<210>  301
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRL1


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Xaa in position 1 is a threonine or serine residue

<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  Xaa in position 3 is a serine, threonine, or aspartate residue

<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  Xaa in position 4 is an asparagine, arginine, alanine, or serine 
       residue

<220>
<221>  MISC_FEATURE
<222>  (5)..(5)
<223>  Xaa in position 5 is a leucine or serine residue

<220>
<221>  MISC_FEATURE
<222>  (6)..(6)
<223>  Xaa in position 6 is an asparagine, aspartate, or proline residue

<220>
<221>  MISC_FEATURE
<222>  (7)..(7)
<223>  Xaa in position 7 is an isoleucine, valine, or lysine residue

<220>
<221>  MISC_FEATURE
<222>  (8)..(8)
<223>  Xaa in position 8 is a glycine or lysine residue

<220>
<221>  MISC_FEATURE
<222>  (9)..(9)
<223>  Xaa in position 9 is an alanine, threonine, glycine, or tyrosine 
       residue

<220>
<221>  MISC_FEATURE
<222>  (10)..(10)
<223>  Xaa in position 10 is an alanine, glycine, or tyrosine residue

<220>
<221>  MISC_FEATURE
<222>  (11)..(11)
<223>  Xaa in position 11 is a tyrosine, phenylalanine, cysteine, or 
       asparagine residue

<220>
<221>  MISC_FEATURE
<222>  (12)..(12)
<223>  Xaa in position 12 is an asparagine, aspartate, or tyrosine 
       residue, or absent

<220>
<221>  MISC_FEATURE
<222>  (13)..(13)
<223>  Xaa in position 13 is a valine residue, or absent

<220>
<221>  MISC_FEATURE
<222>  (14)..(14)
<223>  Xaa in position 14 is a histidine or serine residue, or absent

<400>  301

Xaa Gly Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
1               5                   10                  


<210>  302
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRL2


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Xaa in position 1 is a valine, serine, aspartate, glutamate, or 
       glycine residue

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa in position 2 is a histidine, aspartate, asparagine, valine, 
       or tyrosine residue

<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  Xaa in position 3 is a histidine, phenylalanine, arginine, 
       serine, or asparagine  residue

<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  Xaa in position 4 is an isoleucine, asparagine or lysine residue

<400>  302

Xaa Xaa Xaa Xaa Arg Pro Ser 
1               5           


<210>  303
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRL3


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Xaa in position 1 is a glutamine, serine, tyrosine, or asparagine
       residue

<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  Xaa in position 3 is a tyrosine or threonine residue

<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  Xaa in position 4 is a serine, aspartate, glycine, or alanine 
       residue

<220>
<221>  MISC_FEATURE
<222>  (5)..(5)
<223>  Xaa in position 5 is a serine, glycine, or asparagine residue

<220>
<221>  MISC_FEATURE
<222>  (6)..(6)
<223>  Xaa in position 6 is a serine, glycine, or arginine residue

<220>
<221>  MISC_FEATURE
<222>  (7)..(7)
<223>  Xaa in position 7 is a leucine, glycine, or asparagine residue

<220>
<221>  MISC_FEATURE
<222>  (8)..(8)
<223>  Xaa in position 8 is a serine or asparagine residue, or absent

<220>
<221>  MISC_FEATURE
<222>  (9)..(9)
<223>  Xaa in position 9 is a histidine or aspartate residue, or absent

<220>
<221>  MISC_FEATURE
<222>  (10)..(10)
<223>  Xaa in position 10 is a serine, glycine, or phenylalanine 
       residue, or absent

<220>
<221>  MISC_FEATURE
<222>  (11)..(11)
<223>  Xaa in position 11 is a valine, serine, tryptophan, aspartate, or
       threonine residue

<220>
<221>  MISC_FEATURE
<222>  (12)..(12)
<223>  Xaa in position 12 is a leucine or valine residue

<400>  303

Xaa Ser Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
1               5                   10          


<210>  304
<211>  63
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer Sequence

<400>  304
ggtcgactga accaccatgc atcatcatca ccaccaccat ccggagcccg ccccgccccc       60

gag                                                                     63


<210>  305
<211>  921
<212>  DNA
<213>  Macaca fascicularis


<220>
<221>  misc_feature
<223>  Cyno Orai1 Encoding

<220>
<221>  CDS
<222>  (1)..(921)

<400>  305
atg cat ccg gag ccc gcc ccg ccc ccg agc cgc agc agc ccc gag ctt         48
Met His Pro Glu Pro Ala Pro Pro Pro Ser Arg Ser Ser Pro Glu Leu           
1               5                   10                  15                

ccc ccg agc ggc ggc agc acc acc agc ggt agc cgc cgg agc cgc cgc         96
Pro Pro Ser Gly Gly Ser Thr Thr Ser Gly Ser Arg Arg Ser Arg Arg           
            20                  25                  30                    

cgc agc ggg gac ggg gag cct ccg gga gcc ccg ccg ccg ccg ccg ccg        144
Arg Ser Gly Asp Gly Glu Pro Pro Gly Ala Pro Pro Pro Pro Pro Pro           
        35                  40                  45                        

ccg ccg ccg ccg ccc gcc gtc acc tac ccg gac tgg atc ggc cag agt        192
Pro Pro Pro Pro Pro Ala Val Thr Tyr Pro Asp Trp Ile Gly Gln Ser           
    50                  55                  60                            

tac tcc gag gtg atg agt ctc aac gag cac tcc atg cag gcg ctg tcc        240
Tyr Ser Glu Val Met Ser Leu Asn Glu His Ser Met Gln Ala Leu Ser           
65                  70                  75                  80            

tgg cgc aag ctc tat ttg agc cgc gcc aag ctc aaa gcc tcc agc cgg        288
Trp Arg Lys Leu Tyr Leu Ser Arg Ala Lys Leu Lys Ala Ser Ser Arg           
                85                  90                  95                

acc tcg gct ctg ctc tcc ggc ttc gcc atg gtg gca atg gtg gag gtg        336
Thr Ser Ala Leu Leu Ser Gly Phe Ala Met Val Ala Met Val Glu Val           
            100                 105                 110                   

cag ctg gac gct gac cac gac tac ccg cca ggg ctg ctc atc gcc ttc        384
Gln Leu Asp Ala Asp His Asp Tyr Pro Pro Gly Leu Leu Ile Ala Phe           
        115                 120                 125                       

agt gcc tgc acc acg gtg ctg gtg gct gtg cac ctg ttt gca ctc atg        432
Ser Ala Cys Thr Thr Val Leu Val Ala Val His Leu Phe Ala Leu Met           
    130                 135                 140                           

atc agc acc tgc atc ctg ccc aac atc gag gcg gtg agc aac gtg cac        480
Ile Ser Thr Cys Ile Leu Pro Asn Ile Glu Ala Val Ser Asn Val His           
145                 150                 155                 160           

aac ctc aac tcg gtc aag gag tcc ccc cac gag cgc atg cac cgc cac        528
Asn Leu Asn Ser Val Lys Glu Ser Pro His Glu Arg Met His Arg His           
                165                 170                 175               

atc gag ctg gcc tgg gcc ttc tcc acc gtc atc ggc acg ctg ctt ttc        576
Ile Glu Leu Ala Trp Ala Phe Ser Thr Val Ile Gly Thr Leu Leu Phe           
            180                 185                 190                   

ctg gcc gag gtc gtg ctg ctc tgc tgg gtc aag ttc ttg ccc ctc aag        624
Leu Ala Glu Val Val Leu Leu Cys Trp Val Lys Phe Leu Pro Leu Lys           
        195                 200                 205                       

aag cag cca ggc cag ccg agg ccc acc agc aag ccc ccc gcc agt ggt        672
Lys Gln Pro Gly Gln Pro Arg Pro Thr Ser Lys Pro Pro Ala Ser Gly           
    210                 215                 220                           

gca gcc gcc aac gtc agc acc agc ggc atc acc ccg ggc cag gca gcc        720
Ala Ala Ala Asn Val Ser Thr Ser Gly Ile Thr Pro Gly Gln Ala Ala           
225                 230                 235                 240           

gcc atc gcc tcg acc acc atc atg gtg ccc ttc ggc ctg atc ttt att        768
Ala Ile Ala Ser Thr Thr Ile Met Val Pro Phe Gly Leu Ile Phe Ile           
                245                 250                 255               

gtc ttc gcc gtc cac ttc tac cgc tca ctg gtc agc cat aag acg gac        816
Val Phe Ala Val His Phe Tyr Arg Ser Leu Val Ser His Lys Thr Asp           
            260                 265                 270                   

cga cag ttc cag gag ctc aac gag ctg gcg gag ttt gct cgc tta cag        864
Arg Gln Phe Gln Glu Leu Asn Glu Leu Ala Glu Phe Ala Arg Leu Gln           
        275                 280                 285                       

gac cag ctg gac cac aga ggg gac cac ccc ctg acg ccc ggc agc cac        912
Asp Gln Leu Asp His Arg Gly Asp His Pro Leu Thr Pro Gly Ser His           
    290                 295                 300                           

tat gcc tag                                                            921
Tyr Ala                                                                   
305                                                                       


<210>  306
<211>  306
<212>  PRT
<213>  Macaca fascicularis

<400>  306

Met His Pro Glu Pro Ala Pro Pro Pro Ser Arg Ser Ser Pro Glu Leu 
1               5                   10                  15      


Pro Pro Ser Gly Gly Ser Thr Thr Ser Gly Ser Arg Arg Ser Arg Arg 
            20                  25                  30          


Arg Ser Gly Asp Gly Glu Pro Pro Gly Ala Pro Pro Pro Pro Pro Pro 
        35                  40                  45              


Pro Pro Pro Pro Pro Ala Val Thr Tyr Pro Asp Trp Ile Gly Gln Ser 
    50                  55                  60                  


Tyr Ser Glu Val Met Ser Leu Asn Glu His Ser Met Gln Ala Leu Ser 
65                  70                  75                  80  


Trp Arg Lys Leu Tyr Leu Ser Arg Ala Lys Leu Lys Ala Ser Ser Arg 
                85                  90                  95      


Thr Ser Ala Leu Leu Ser Gly Phe Ala Met Val Ala Met Val Glu Val 
            100                 105                 110         


Gln Leu Asp Ala Asp His Asp Tyr Pro Pro Gly Leu Leu Ile Ala Phe 
        115                 120                 125             


Ser Ala Cys Thr Thr Val Leu Val Ala Val His Leu Phe Ala Leu Met 
    130                 135                 140                 


Ile Ser Thr Cys Ile Leu Pro Asn Ile Glu Ala Val Ser Asn Val His 
145                 150                 155                 160 


Asn Leu Asn Ser Val Lys Glu Ser Pro His Glu Arg Met His Arg His 
                165                 170                 175     


Ile Glu Leu Ala Trp Ala Phe Ser Thr Val Ile Gly Thr Leu Leu Phe 
            180                 185                 190         


Leu Ala Glu Val Val Leu Leu Cys Trp Val Lys Phe Leu Pro Leu Lys 
        195                 200                 205             


Lys Gln Pro Gly Gln Pro Arg Pro Thr Ser Lys Pro Pro Ala Ser Gly 
    210                 215                 220                 


Ala Ala Ala Asn Val Ser Thr Ser Gly Ile Thr Pro Gly Gln Ala Ala 
225                 230                 235                 240 


Ala Ile Ala Ser Thr Thr Ile Met Val Pro Phe Gly Leu Ile Phe Ile 
                245                 250                 255     


Val Phe Ala Val His Phe Tyr Arg Ser Leu Val Ser His Lys Thr Asp 
            260                 265                 270         


Arg Gln Phe Gln Glu Leu Asn Glu Leu Ala Glu Phe Ala Arg Leu Gln 
        275                 280                 285             


Asp Gln Leu Asp His Arg Gly Asp His Pro Leu Thr Pro Gly Ser His 
    290                 295                 300                 


Tyr Ala 
305     


<210>  307
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer Sequence

<400>  307
gatgcatccg gagcccgc                                                     18


<210>  308
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer Sequence

<400>  308
gctcgttgag ctcctggaac                                                   20


<210>  309
<211>  46
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer Sequence


<220>
<221>  misc_feature
<223>  Primer Sequence

<400>  309
cctcaacgag cactccatgc aggcctcaac gagcactcca tgcagg                      46


<210>  310
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer Sequence

<400>  310
ctcttagagg acagtttcaa agtg                                              24


<210>  311
<211>  51
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer Sequence

<400>  311
gaagctttga accaccatgc atccggagcc cgccccgccc ccgagccgca g                51


<210>  312
<211>  26
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer Sequence

<400>  312
gcggccgcct aggcatagtg gctgcc                                            26


<210>  313
<211>  36
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<223>  Human Orai1 variant (N223S) (Residues 198-233 of SEQ ID NO:317)

<400>  313

Lys Phe Leu Pro Leu Lys Lys Gln Pro Gly Gln Pro Arg Pro Thr Ser 
1               5                   10                  15      


Lys Pro Pro Ala Ser Gly Ala Ala Ala Ser Val Ser Thr Ser Gly Ile 
            20                  25                  30          


Thr Pro Gly Gln 
        35      


<210>  314
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer Sequence

<400>  314
ggcgcagcag ccagcgtcag cacca                                             25


<210>  315
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer Sequence

<400>  315
tggtgctgac gctggctgct gcgcc                                             25


<210>  316
<211>  906
<212>  DNA
<213>  Homo sapiens


<220>
<221>  misc_feature
<223>  Human Orai1 variant (N223S) coding sequence

<220>
<221>  CDS
<222>  (1)..(906)

<400>  316
atg cat ccg gag ccc gcc ccg ccc ccg agc cgc agc agt ccc gag ctt         48
Met His Pro Glu Pro Ala Pro Pro Pro Ser Arg Ser Ser Pro Glu Leu           
1               5                   10                  15                

ccc cca agc ggc ggc agc acc acc agc ggc agc cgc cgg agc cgc cgc         96
Pro Pro Ser Gly Gly Ser Thr Thr Ser Gly Ser Arg Arg Ser Arg Arg           
            20                  25                  30                    

cgc agc ggg gac ggg gag ccc ccg ggg gcc ccg cca ccg ccg ccg tcc        144
Arg Ser Gly Asp Gly Glu Pro Pro Gly Ala Pro Pro Pro Pro Pro Ser           
        35                  40                  45                        

gcc gtc acc tac ccg gac tgg atc ggc cag agt tac tcc gag gtg atg        192
Ala Val Thr Tyr Pro Asp Trp Ile Gly Gln Ser Tyr Ser Glu Val Met           
    50                  55                  60                            

agc ctc aac gag cac tcc atg cag gcg ctg tcc tgg cgc aag ctc tac        240
Ser Leu Asn Glu His Ser Met Gln Ala Leu Ser Trp Arg Lys Leu Tyr           
65                  70                  75                  80            

ttg agc cgc gcc aag ctt aaa gcc tcc agc cgg acc tcg gct ctg ctc        288
Leu Ser Arg Ala Lys Leu Lys Ala Ser Ser Arg Thr Ser Ala Leu Leu           
                85                  90                  95                

tcc ggc ttc gcc atg gtg gca atg gtg gag gtg cag ctg gac gct gac        336
Ser Gly Phe Ala Met Val Ala Met Val Glu Val Gln Leu Asp Ala Asp           
            100                 105                 110                   

cac gac tac cca ccg ggg ctg ctc atc gcc ttc agt gcc tgc acc aca        384
His Asp Tyr Pro Pro Gly Leu Leu Ile Ala Phe Ser Ala Cys Thr Thr           
        115                 120                 125                       

gtg ctg gtg gct gtg cac ctg ttt gcg ctc atg atc agc acc tgc atc        432
Val Leu Val Ala Val His Leu Phe Ala Leu Met Ile Ser Thr Cys Ile           
    130                 135                 140                           

ctg ccc aac atc gag gcg gtg agc aac gtg cac aat ctc aac tcg gtc        480
Leu Pro Asn Ile Glu Ala Val Ser Asn Val His Asn Leu Asn Ser Val           
145                 150                 155                 160           

aag gag tcc ccc cat gag cgc atg cac cgc cac atc gag ctg gcc tgg        528
Lys Glu Ser Pro His Glu Arg Met His Arg His Ile Glu Leu Ala Trp           
                165                 170                 175               

gcc ttc tcc acc gtc atc ggc acg ctg ctc ttc cta gct gag gtg gtg        576
Ala Phe Ser Thr Val Ile Gly Thr Leu Leu Phe Leu Ala Glu Val Val           
            180                 185                 190                   

ctg ctc tgc tgg gtc aag ttc ttg ccc ctc aag aag cag cca ggc cag        624
Leu Leu Cys Trp Val Lys Phe Leu Pro Leu Lys Lys Gln Pro Gly Gln           
        195                 200                 205                       

cca agg ccc acc agc aag ccc ccc gcc agt ggc gca gca gcc agc gtc        672
Pro Arg Pro Thr Ser Lys Pro Pro Ala Ser Gly Ala Ala Ala Ser Val           
    210                 215                 220                           

agc acc agc ggc atc acc ccg ggc cag gca gct gcc atc gcc tcg acc        720
Ser Thr Ser Gly Ile Thr Pro Gly Gln Ala Ala Ala Ile Ala Ser Thr           
225                 230                 235                 240           

acc atc atg gtg ccc ttc ggc ctg atc ttt atc gtc ttc gcc gtc cac        768
Thr Ile Met Val Pro Phe Gly Leu Ile Phe Ile Val Phe Ala Val His           
                245                 250                 255               

ttc tac cgc tca ctg gtt agc cat aag acc gac cga cag ttc cag gag        816
Phe Tyr Arg Ser Leu Val Ser His Lys Thr Asp Arg Gln Phe Gln Glu           
            260                 265                 270                   

ctc aac gag ctg gcg gag ttt gcc cgc tta cag gac cag ctg gac cac        864
Leu Asn Glu Leu Ala Glu Phe Ala Arg Leu Gln Asp Gln Leu Asp His           
        275                 280                 285                       

aga ggg gac cac ccc ctg acg ccc ggc agc cac tat gcc tag                906
Arg Gly Asp His Pro Leu Thr Pro Gly Ser His Tyr Ala                       
    290                 295                 300                           


<210>  317
<211>  301
<212>  PRT
<213>  Homo sapiens

<400>  317

Met His Pro Glu Pro Ala Pro Pro Pro Ser Arg Ser Ser Pro Glu Leu 
1               5                   10                  15      


Pro Pro Ser Gly Gly Ser Thr Thr Ser Gly Ser Arg Arg Ser Arg Arg 
            20                  25                  30          


Arg Ser Gly Asp Gly Glu Pro Pro Gly Ala Pro Pro Pro Pro Pro Ser 
        35                  40                  45              


Ala Val Thr Tyr Pro Asp Trp Ile Gly Gln Ser Tyr Ser Glu Val Met 
    50                  55                  60                  


Ser Leu Asn Glu His Ser Met Gln Ala Leu Ser Trp Arg Lys Leu Tyr 
65                  70                  75                  80  


Leu Ser Arg Ala Lys Leu Lys Ala Ser Ser Arg Thr Ser Ala Leu Leu 
                85                  90                  95      


Ser Gly Phe Ala Met Val Ala Met Val Glu Val Gln Leu Asp Ala Asp 
            100                 105                 110         


His Asp Tyr Pro Pro Gly Leu Leu Ile Ala Phe Ser Ala Cys Thr Thr 
        115                 120                 125             


Val Leu Val Ala Val His Leu Phe Ala Leu Met Ile Ser Thr Cys Ile 
    130                 135                 140                 


Leu Pro Asn Ile Glu Ala Val Ser Asn Val His Asn Leu Asn Ser Val 
145                 150                 155                 160 


Lys Glu Ser Pro His Glu Arg Met His Arg His Ile Glu Leu Ala Trp 
                165                 170                 175     


Ala Phe Ser Thr Val Ile Gly Thr Leu Leu Phe Leu Ala Glu Val Val 
            180                 185                 190         


Leu Leu Cys Trp Val Lys Phe Leu Pro Leu Lys Lys Gln Pro Gly Gln 
        195                 200                 205             


Pro Arg Pro Thr Ser Lys Pro Pro Ala Ser Gly Ala Ala Ala Ser Val 
    210                 215                 220                 


Ser Thr Ser Gly Ile Thr Pro Gly Gln Ala Ala Ala Ile Ala Ser Thr 
225                 230                 235                 240 


Thr Ile Met Val Pro Phe Gly Leu Ile Phe Ile Val Phe Ala Val His 
                245                 250                 255     


Phe Tyr Arg Ser Leu Val Ser His Lys Thr Asp Arg Gln Phe Gln Glu 
            260                 265                 270         


Leu Asn Glu Leu Ala Glu Phe Ala Arg Leu Gln Asp Gln Leu Asp His 
        275                 280                 285             


Arg Gly Asp His Pro Leu Thr Pro Gly Ser His Tyr Ala 
    290                 295                 300     


<210>  318
<211>  972
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  6x-His-human Orai1 coding sequence


<220>
<221>  CDS
<222>  (1)..(936)

<400>  318
atg aaa cat cat cac cat cac cat cac atg cat ccg gag ccc gcc ccg         48
Met Lys His His His His His His His Met His Pro Glu Pro Ala Pro           
1               5                   10                  15                

ccc ccg agc cgc agc agt ccc gag ctt ccc cca agc ggc ggc agc acc         96
Pro Pro Ser Arg Ser Ser Pro Glu Leu Pro Pro Ser Gly Gly Ser Thr           
            20                  25                  30                    

acc agc ggc agc cgc cgg agc cgc cgc cgc agc ggg gac ggg gag ccc        144
Thr Ser Gly Ser Arg Arg Ser Arg Arg Arg Ser Gly Asp Gly Glu Pro           
        35                  40                  45                        

ccg ggg gcc ccg cca ccg ccg ccg tcc gcc gtc acc tac ccg gac tgg        192
Pro Gly Ala Pro Pro Pro Pro Pro Ser Ala Val Thr Tyr Pro Asp Trp           
    50                  55                  60                            

atc ggc cag agt tac tcc gag gtg atg agc ctc aac gag cac tcc atg        240
Ile Gly Gln Ser Tyr Ser Glu Val Met Ser Leu Asn Glu His Ser Met           
65                  70                  75                  80            

cag gcg ctg tcc tgg cgc aag ctc tac ttg agc cgc gcc aag ctt aaa        288
Gln Ala Leu Ser Trp Arg Lys Leu Tyr Leu Ser Arg Ala Lys Leu Lys           
                85                  90                  95                

gcc tcc agc cgg acc tcg gct ctg ctc tcc ggc ttc gcc atg gtg gca        336
Ala Ser Ser Arg Thr Ser Ala Leu Leu Ser Gly Phe Ala Met Val Ala           
            100                 105                 110                   

atg gtg gag gtg cag ctg gac gct gac cac gac tac cca ccg ggg ctg        384
Met Val Glu Val Gln Leu Asp Ala Asp His Asp Tyr Pro Pro Gly Leu           
        115                 120                 125                       

ctc atc gcc ttc agt gcc tgc acc aca gtg ctg gtg gct gtg cac ctg        432
Leu Ile Ala Phe Ser Ala Cys Thr Thr Val Leu Val Ala Val His Leu           
    130                 135                 140                           

ttt gcg ctc atg atc agc acc tgc atc ctg ccc aac atc gag gcg gtg        480
Phe Ala Leu Met Ile Ser Thr Cys Ile Leu Pro Asn Ile Glu Ala Val           
145                 150                 155                 160           

agc aac gtg cac aat ctc aac tcg gtc aag gag tcc ccc cat gag cgc        528
Ser Asn Val His Asn Leu Asn Ser Val Lys Glu Ser Pro His Glu Arg           
                165                 170                 175               

atg cac cgc cac atc gag ctg gcc tgg gcc ttc tcc acc gtc atc ggc        576
Met His Arg His Ile Glu Leu Ala Trp Ala Phe Ser Thr Val Ile Gly           
            180                 185                 190                   

acg ctg ctc ttc cta gct gag gtg gtg ctg ctc tgc tgg gtc aag ttc        624
Thr Leu Leu Phe Leu Ala Glu Val Val Leu Leu Cys Trp Val Lys Phe           
        195                 200                 205                       

ttg ccc ctc aag aag cag cca ggc cag cca agg ccc acc agc aag ccc        672
Leu Pro Leu Lys Lys Gln Pro Gly Gln Pro Arg Pro Thr Ser Lys Pro           
    210                 215                 220                           

ccc gcc agt ggc gca gca gcc aac gtc agc acc agc ggc atc acc ccg        720
Pro Ala Ser Gly Ala Ala Ala Asn Val Ser Thr Ser Gly Ile Thr Pro           
225                 230                 235                 240           

ggc cag gca gct gcc atc gcc tcg acc acc atc atg gtg ccc ttc ggc        768
Gly Gln Ala Ala Ala Ile Ala Ser Thr Thr Ile Met Val Pro Phe Gly           
                245                 250                 255               

ctg atc ttt atc gtc ttc gcc gtc cac ttc tac cgc tca ctg gtt agc        816
Leu Ile Phe Ile Val Phe Ala Val His Phe Tyr Arg Ser Leu Val Ser           
            260                 265                 270                   

cat aag acc gac cga cag ttc cag gag ctc aac gag ctg gcg gag ttt        864
His Lys Thr Asp Arg Gln Phe Gln Glu Leu Asn Glu Leu Ala Glu Phe           
        275                 280                 285                       

gcc cgc tta cag gac cag ctg gac cac aga ggg gac cac ccc ctg acg        912
Ala Arg Leu Gln Asp Gln Leu Asp His Arg Gly Asp His Pro Leu Thr           
    290                 295                 300                           

ccc ggc agc cac tat gcc tag taa ctcgaggatc cgcggaaaga agaagaagaa       966
Pro Gly Ser His Tyr Ala                                                   
305                 310                                                   

gaagaa                                                                 972


<210>  319
<211>  310
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  319

Met Lys His His His His His His His Met His Pro Glu Pro Ala Pro 
1               5                   10                  15      


Pro Pro Ser Arg Ser Ser Pro Glu Leu Pro Pro Ser Gly Gly Ser Thr 
            20                  25                  30          


Thr Ser Gly Ser Arg Arg Ser Arg Arg Arg Ser Gly Asp Gly Glu Pro 
        35                  40                  45              


Pro Gly Ala Pro Pro Pro Pro Pro Ser Ala Val Thr Tyr Pro Asp Trp 
    50                  55                  60                  


Ile Gly Gln Ser Tyr Ser Glu Val Met Ser Leu Asn Glu His Ser Met 
65                  70                  75                  80  


Gln Ala Leu Ser Trp Arg Lys Leu Tyr Leu Ser Arg Ala Lys Leu Lys 
                85                  90                  95      


Ala Ser Ser Arg Thr Ser Ala Leu Leu Ser Gly Phe Ala Met Val Ala 
            100                 105                 110         


Met Val Glu Val Gln Leu Asp Ala Asp His Asp Tyr Pro Pro Gly Leu 
        115                 120                 125             


Leu Ile Ala Phe Ser Ala Cys Thr Thr Val Leu Val Ala Val His Leu 
    130                 135                 140                 


Phe Ala Leu Met Ile Ser Thr Cys Ile Leu Pro Asn Ile Glu Ala Val 
145                 150                 155                 160 


Ser Asn Val His Asn Leu Asn Ser Val Lys Glu Ser Pro His Glu Arg 
                165                 170                 175     


Met His Arg His Ile Glu Leu Ala Trp Ala Phe Ser Thr Val Ile Gly 
            180                 185                 190         


Thr Leu Leu Phe Leu Ala Glu Val Val Leu Leu Cys Trp Val Lys Phe 
        195                 200                 205             


Leu Pro Leu Lys Lys Gln Pro Gly Gln Pro Arg Pro Thr Ser Lys Pro 
    210                 215                 220                 


Pro Ala Ser Gly Ala Ala Ala Asn Val Ser Thr Ser Gly Ile Thr Pro 
225                 230                 235                 240 


Gly Gln Ala Ala Ala Ile Ala Ser Thr Thr Ile Met Val Pro Phe Gly 
                245                 250                 255     


Leu Ile Phe Ile Val Phe Ala Val His Phe Tyr Arg Ser Leu Val Ser 
            260                 265                 270         


His Lys Thr Asp Arg Gln Phe Gln Glu Leu Asn Glu Leu Ala Glu Phe 
        275                 280                 285             


Ala Arg Leu Gln Asp Gln Leu Asp His Arg Gly Asp His Pro Leu Thr 
    290                 295                 300                 


Pro Gly Ser His Tyr Ala 
305                 310 


<210>  320
<211>  35
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer Sequence

<400>  320
ctgacgcccg gcagccacta tgcctaggcg gccgc                                  35


<210>  321
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  6x-His

<400>  321

His His His His His His 
1               5       


<210>  322
<211>  217
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  L4 amino acid seqence (minus signal sequence)

<400>  322

Gln Ser Val Leu Thr Gln Pro Pro Ser Val Ser Gly Ala Pro Gly Gln 
1               5                   10                  15      


Arg Val Thr Ile Ser Cys Thr Gly Ser Ser Ser Asn Ile Gly Ala Gly 
            20                  25                  30          


Tyr Asn Val His Trp Tyr Gln Gln Phe Pro Arg Thr Asp Pro Lys Leu 
        35                  40                  45              


Leu Ile Tyr Val Tyr Asn Ile Arg Pro Ser Gly Val Pro Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Arg Ser Gly Thr Ser Ala Ser Leu Ala Ile Thr Gly Leu 
65                  70                  75                  80  


Gln Thr Glu Asp Glu Ala Asp Tyr Tyr Cys Gln Ser Tyr Asp Ser Ser 
                85                  90                  95      


Leu Ser Gly Val Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly 
            100                 105                 110         


Gln Pro Lys Ala Asn Pro Thr Val Thr Leu Phe Pro Pro Ser Ser Glu 
        115                 120                 125             


Glu Leu Gln Ala Asn Lys Ala Thr Leu Val Cys Leu Ile Ser Asp Phe 
    130                 135                 140                 


Tyr Pro Gly Ala Val Thr Val Ala Trp Lys Ala Asp Gly Ser Pro Val 
145                 150                 155                 160 


Lys Ala Gly Val Glu Thr Thr Lys Pro Ser Lys Gln Ser Asn Asn Lys 
                165                 170                 175     


Tyr Ala Ala Ser Ser Tyr Leu Ser Leu Thr Pro Glu Gln Trp Lys Ser 
            180                 185                 190         


His Arg Ser Tyr Ser Cys Gln Val Thr His Glu Gly Ser Thr Val Glu 
        195                 200                 205             


Lys Thr Val Ala Pro Thr Glu Cys Ser 
    210                 215         


<210>  323
<211>  217
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  L5 amino acid sequence (minus signal sequence)

<400>  323

Gln Ser Val Leu Thr Gln Pro Pro Ser Val Ser Gly Ala Pro Gly Gln 
1               5                   10                  15      


Arg Val Thr Ile Ser Cys Thr Gly Ser Ser Ser Asn Ile Gly Thr Gly 
            20                  25                  30          


Tyr Asn Val His Trp Tyr Gln Gln Phe Pro Arg Thr Asp Pro Lys Leu 
        35                  40                  45              


Leu Ile Tyr Val Tyr Asn Ile Arg Pro Ser Gly Val Pro Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Arg Ser Gly Thr Ser Ala Ser Leu Ala Ile Thr Gly Leu 
65                  70                  75                  80  


Gln Thr Glu Asp Glu Ala Asp Tyr Tyr Cys Gln Ser Tyr Asp Ser Ser 
                85                  90                  95      


Leu Ser Gly Val Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly 
            100                 105                 110         


Gln Pro Lys Ala Asn Pro Thr Val Thr Leu Phe Pro Pro Ser Ser Glu 
        115                 120                 125             


Glu Leu Gln Ala Asn Lys Ala Thr Leu Val Cys Leu Ile Ser Asp Phe 
    130                 135                 140                 


Tyr Pro Gly Ala Val Thr Val Ala Trp Lys Ala Asp Gly Ser Pro Val 
145                 150                 155                 160 


Lys Ala Gly Val Glu Thr Thr Lys Pro Ser Lys Gln Ser Asn Asn Lys 
                165                 170                 175     


Tyr Ala Ala Ser Ser Tyr Leu Ser Leu Thr Pro Glu Gln Trp Lys Ser 
            180                 185                 190         


His Arg Ser Tyr Ser Cys Gln Val Thr His Glu Gly Ser Thr Val Glu 
        195                 200                 205             


Lys Thr Val Ala Pro Thr Glu Cys Ser 
    210                 215         


<210>  324
<211>  217
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  L6 amino acid sequence (minus signal sequence)

<400>  324

Gln Ser Val Leu Thr Gln Pro Pro Ser Val Ser Gly Ala Pro Gly Gln 
1               5                   10                  15      


Arg Val Thr Ile Ser Cys Thr Gly Ser Asn Ser Asn Ile Gly Thr Gly 
            20                  25                  30          


Tyr Asp Val His Trp Tyr Gln Lys Leu Pro Gly Thr Ala Pro Arg Leu 
        35                  40                  45              


Leu Ile Tyr Ser His Phe Asn Arg Pro Ser Gly Val Pro Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Thr Ser Gly Thr Ser Ala Ser Leu Ala Ile Thr Gly Leu 
65                  70                  75                  80  


Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Gln Ser Tyr Asp Ser Ser 
                85                  90                  95      


Leu Ser Gly Ser Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly 
            100                 105                 110         


Gln Pro Lys Ala Asn Pro Thr Val Thr Leu Phe Pro Pro Ser Ser Glu 
        115                 120                 125             


Glu Leu Gln Ala Asn Lys Ala Thr Leu Val Cys Leu Ile Ser Asp Phe 
    130                 135                 140                 


Tyr Pro Gly Ala Val Thr Val Ala Trp Lys Ala Asp Gly Ser Pro Val 
145                 150                 155                 160 


Lys Ala Gly Val Glu Thr Thr Lys Pro Ser Lys Gln Ser Asn Asn Lys 
                165                 170                 175     


Tyr Ala Ala Ser Ser Tyr Leu Ser Leu Thr Pro Glu Gln Trp Lys Ser 
            180                 185                 190         


His Arg Ser Tyr Ser Cys Gln Val Thr His Glu Gly Ser Thr Val Glu 
        195                 200                 205             


Lys Thr Val Ala Pro Thr Glu Cys Ser 
    210                 215         


<210>  325
<211>  446
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  H5 amino acid sequence (minus signal sequence)

<400>  325

Gln Val Gln Leu Gln Gln Trp Gly Ala Gly Leu Leu Lys Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Ala Val Tyr Gly Gly Ser Phe Ser Gly Tyr 
            20                  25                  30          


Tyr Trp Ser Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Glu Ile Asp His Ser Gly Arg Ile Asn Tyr Asn Pro Ala Leu Lys 
    50                  55                  60                  


Ser Arg Leu Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe Ser Leu 
65                  70                  75                  80  


Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Ala Gly Ser Gly Gly Tyr Glu Asp Trp Phe Asp Pro Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val 
        115                 120                 125             


Phe Pro Leu Ala Pro Cys Ser Arg Ser Thr Ser Glu Ser Thr Ala Ala 
    130                 135                 140                 


Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser 
145                 150                 155                 160 


Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val 
                165                 170                 175     


Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro 
            180                 185                 190         


Ser Ser Asn Phe Gly Thr Gln Thr Tyr Thr Cys Asn Val Asp His Lys 
        195                 200                 205             


Pro Ser Asn Thr Lys Val Asp Lys Thr Val Glu Arg Lys Cys Cys Val 
    210                 215                 220                 


Glu Cys Pro Pro Cys Pro Ala Pro Pro Val Ala Gly Pro Ser Val Phe 
225                 230                 235                 240 


Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro 
                245                 250                 255     


Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val 
            260                 265                 270         


Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr 
        275                 280                 285             


Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Phe Arg Val Val Ser Val 
    290                 295                 300                 


Leu Thr Val Val His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys 
305                 310                 315                 320 


Lys Val Ser Asn Lys Gly Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser 
                325                 330                 335     


Lys Thr Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro 
            340                 345                 350         


Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val 
        355                 360                 365             


Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly 
    370                 375                 380                 


Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Met Leu Asp Ser Asp 
385                 390                 395                 400 


Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp 
                405                 410                 415     


Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His 
            420                 425                 430         


Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
        435                 440                 445     


<210>  326
<211>  446
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  H6 amino acid sequence (minus signal sequence)

<400>  326

Gln Val Gln Leu Gln Gln Trp Gly Ala Gly Leu Leu Lys Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Ala Val Tyr Gly Gly Ser Phe Ser Gly Tyr 
            20                  25                  30          


Tyr Trp Ser Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Glu Ile Asp His Ser Gly Ser Thr Asn Tyr Asn Pro Ala Leu Lys 
    50                  55                  60                  


Ser Arg Leu Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe Ser Leu 
65                  70                  75                  80  


Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Ala Gly Ser Gly Gly Tyr Glu Asp Trp Phe Asp Pro Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val 
        115                 120                 125             


Phe Pro Leu Ala Pro Cys Ser Arg Ser Thr Ser Glu Ser Thr Ala Ala 
    130                 135                 140                 


Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser 
145                 150                 155                 160 


Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val 
                165                 170                 175     


Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro 
            180                 185                 190         


Ser Ser Asn Phe Gly Thr Gln Thr Tyr Thr Cys Asn Val Asp His Lys 
        195                 200                 205             


Pro Ser Asn Thr Lys Val Asp Lys Thr Val Glu Arg Lys Cys Cys Val 
    210                 215                 220                 


Glu Cys Pro Pro Cys Pro Ala Pro Pro Val Ala Gly Pro Ser Val Phe 
225                 230                 235                 240 


Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro 
                245                 250                 255     


Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val 
            260                 265                 270         


Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr 
        275                 280                 285             


Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Phe Arg Val Val Ser Val 
    290                 295                 300                 


Leu Thr Val Val His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys 
305                 310                 315                 320 


Lys Val Ser Asn Lys Gly Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser 
                325                 330                 335     


Lys Thr Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro 
            340                 345                 350         


Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val 
        355                 360                 365             


Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly 
    370                 375                 380                 


Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Met Leu Asp Ser Asp 
385                 390                 395                 400 


Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp 
                405                 410                 415     


Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His 
            420                 425                 430         


Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
        435                 440                 445     


<210>  327
<211>  446
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  H7 amino acid sequence (minus signal sequence)

<400>  327

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Trp Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Asn Ile Lys His Asp Gly Ser Glu Lys Tyr Tyr Val Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu His 
65                  70                  75                  80  


Leu Gln Met Ile Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Arg Tyr Ser Gly Gly Trp Thr Phe Phe Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val 
        115                 120                 125             


Phe Pro Leu Ala Pro Cys Ser Arg Ser Thr Ser Glu Ser Thr Ala Ala 
    130                 135                 140                 


Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser 
145                 150                 155                 160 


Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val 
                165                 170                 175     


Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro 
            180                 185                 190         


Ser Ser Asn Phe Gly Thr Gln Thr Tyr Thr Cys Asn Val Asp His Lys 
        195                 200                 205             


Pro Ser Asn Thr Lys Val Asp Lys Thr Val Glu Arg Lys Cys Cys Val 
    210                 215                 220                 


Glu Cys Pro Pro Cys Pro Ala Pro Pro Val Ala Gly Pro Ser Val Phe 
225                 230                 235                 240 


Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro 
                245                 250                 255     


Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val 
            260                 265                 270         


Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr 
        275                 280                 285             


Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Phe Arg Val Val Ser Val 
    290                 295                 300                 


Leu Thr Val Val His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys 
305                 310                 315                 320 


Lys Val Ser Asn Lys Gly Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser 
                325                 330                 335     


Lys Thr Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro 
            340                 345                 350         


Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val 
        355                 360                 365             


Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly 
    370                 375                 380                 


Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Met Leu Asp Ser Asp 
385                 390                 395                 400 


Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp 
                405                 410                 415     


Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His 
            420                 425                 430         


Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
        435                 440                 445     


<210>  328
<211>  444
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  H8 amino acid sequence (minus signal sequence)

<400>  328

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asp Tyr 
            20                  25                  30          


Tyr Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Asn Pro Asn Ser Gly Gly Thr Asn Tyr Val Gln Lys Phe 
    50                  55                  60                  


Gln Asp Arg Val Thr Met Thr Arg Asp Thr Ser Ile Thr Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Thr Arg Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Glu Glu Gly Asp Tyr Gly Met Asp Val Trp Gly Gln Gly Thr 
            100                 105                 110         


Thr Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro 
        115                 120                 125             


Leu Ala Pro Cys Ser Arg Ser Thr Ser Glu Ser Thr Ala Ala Leu Gly 
    130                 135                 140                 


Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn 
145                 150                 155                 160 


Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln 
                165                 170                 175     


Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser 
            180                 185                 190         


Asn Phe Gly Thr Gln Thr Tyr Thr Cys Asn Val Asp His Lys Pro Ser 
        195                 200                 205             


Asn Thr Lys Val Asp Lys Thr Val Glu Arg Lys Cys Cys Val Glu Cys 
    210                 215                 220                 


Pro Pro Cys Pro Ala Pro Pro Val Ala Gly Pro Ser Val Phe Leu Phe 
225                 230                 235                 240 


Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val 
                245                 250                 255     


Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Gln Phe 
            260                 265                 270         


Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro 
        275                 280                 285             


Arg Glu Glu Gln Phe Asn Ser Thr Phe Arg Val Val Ser Val Leu Thr 
    290                 295                 300                 


Val Val His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val 
305                 310                 315                 320 


Ser Asn Lys Gly Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Thr 
                325                 330                 335     


Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg 
            340                 345                 350         


Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly 
        355                 360                 365             


Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro 
    370                 375                 380                 


Glu Asn Asn Tyr Lys Thr Thr Pro Pro Met Leu Asp Ser Asp Gly Ser 
385                 390                 395                 400 


Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln 
                405                 410                 415     


Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His 
            420                 425                 430         


Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
        435                 440                 


<210>  329
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Signal peptide sequence

<400>  329

Met Glu Ala Pro Ala Gln Leu Leu Phe Leu Leu Leu Leu Trp Leu Pro 
1               5                   10                  15      


Asp Thr Thr Gly 
            20  


<210>  330
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Signal peptide sequence

<400>  330

Met Glu Trp Thr Trp Arg Val Leu Phe Leu Val Ala Ala Ala Thr Gly 
1               5                   10                  15      


Ala His Ser 
            


<210>  331
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Signal peptide sequence

<400>  331

Met Glu Thr Pro Ala Gln Leu Leu Phe Leu Leu Leu Leu Trp Leu Pro 
1               5                   10                  15      


Asp Thr Thr Gly 
            20  


<210>  332
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Signal peptide sequence

<400>  332

Met Lys His Leu Trp Phe Phe Leu Leu Leu Val Ala Ala Pro Arg Trp 
1               5                   10                  15      


Val Leu Ser 
            


<210>  333
<211>  215
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  L7 amino acid sequence

<400>  333

Gln Ser Val Leu Thr Gln Pro Pro Ser Val Ser Gly Ala Pro Gly Gln 
1               5                   10                  15      


Arg Val Thr Ile Ser Cys Thr Gly Ser Ser Ser Asn Ile Gly Ala Gly 
            20                  25                  30          


Phe Asp Val His Trp Tyr Gln Gln Leu Pro Val Thr Ala Pro Lys Leu 
        35                  40                  45              


Leu Ile Tyr Gly Asn Arg Asn Arg Pro Ser Gly Val Pro Ala Arg Phe 
    50                  55                  60                  


Ser Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Thr Gly Leu 
65                  70                  75                  80  


Gln Ala Glu Asp Glu Ala Val Tyr Tyr Cys Gln Ser Tyr Asp Ser Ser 
                85                  90                  95      


Leu Thr Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Gln Pro 
            100                 105                 110         


Lys Ala Asn Pro Thr Val Thr Leu Phe Pro Pro Ser Ser Glu Glu Leu 
        115                 120                 125             


Gln Ala Asn Lys Ala Thr Leu Val Cys Leu Ile Ser Asp Phe Tyr Pro 
    130                 135                 140                 


Gly Ala Val Thr Val Ala Trp Lys Ala Asp Gly Ser Pro Val Lys Ala 
145                 150                 155                 160 


Gly Val Glu Thr Thr Lys Pro Ser Lys Gln Ser Asn Asn Lys Tyr Ala 
                165                 170                 175     


Ala Ser Ser Tyr Leu Ser Leu Thr Pro Glu Gln Trp Lys Ser His Arg 
            180                 185                 190         


Ser Tyr Ser Cys Gln Val Thr His Glu Gly Ser Thr Val Glu Lys Thr 
        195                 200                 205             


Val Ala Pro Thr Glu Cys Ser 
    210                 215 


<210>  334
<211>  215
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  L8 amino acid sequence

<400>  334

Ser Cys Glu Leu Thr Gln Ser Pro Ser Val Ser Val Ser Pro Gly Gln 
1               5                   10                  15      


Thr Ala Arg Ile Thr Cys Ser Gly Asp Ala Leu Pro Lys Lys Tyr Ala 
            20                  25                  30          


Cys Cys Tyr Gln Gln Lys Ser Gly Gln Ala Pro Val Leu Val Val Tyr 
        35                  40                  45              


Asp Asp His Lys Arg Pro Ser Gly Ile Pro Glu Arg Phe Ser Gly Ser 
    50                  55                  60                  


Ser Ser Gly Thr Leu Ala Thr Leu Ile Ile Ser Gly Ala Gln Val Glu 
65                  70                  75                  80  


Asp Glu Ala Asp Ser Tyr Cys Tyr Ser Thr Asp Ser Ser Gly Asn His 
                85                  90                  95      


Ser Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Gln Pro 
            100                 105                 110         


Lys Ala Asn Pro Thr Val Thr Leu Phe Pro Pro Ser Ser Glu Glu Leu 
        115                 120                 125             


Gln Ala Asn Lys Ala Thr Leu Val Cys Leu Ile Ser Asp Phe Tyr Pro 
    130                 135                 140                 


Gly Ala Val Thr Val Ala Trp Lys Ala Asp Gly Ser Pro Val Lys Ala 
145                 150                 155                 160 


Gly Val Glu Thr Thr Lys Pro Ser Lys Gln Ser Asn Asn Lys Tyr Ala 
                165                 170                 175     


Ala Ser Ser Tyr Leu Ser Leu Thr Pro Glu Gln Trp Lys Ser His Arg 
            180                 185                 190         


Ser Tyr Ser Cys Gln Val Thr His Glu Gly Ser Thr Val Glu Lys Thr 
        195                 200                 205             


Val Ala Pro Thr Glu Cys Ser 
    210                 215 


<210>  335
<211>  218
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  L9 amino acid sequence

<400>  335

Gln Ser Val Leu Thr Gln Pro Pro Ser Val Ser Gly Ala Pro Gly Gln 
1               5                   10                  15      


Arg Val Thr Ile Ser Cys Thr Gly Ser Ser Ser Asn Ile Gly Ala Gly 
            20                  25                  30          


Tyr Asp Val His Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu 
        35                  40                  45              


Leu Ile Tyr Gly Asn Ser Asn Arg Pro Ser Gly Val Pro Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Thr Gly Leu 
65                  70                  75                  80  


Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Gln Ser Tyr Asp Asn Arg 
                85                  90                  95      


Leu Ser Asp Ser Val Val Ile Gly Gly Gly Thr Lys Leu Ala Val Gln 
            100                 105                 110         


Gly Gln Pro Lys Ala Asn Pro Thr Val Thr Leu Phe Pro Pro Ser Ser 
        115                 120                 125             


Glu Glu Leu Gln Ala Asn Lys Ala Thr Leu Val Cys Leu Ile Ser Asp 
    130                 135                 140                 


Phe Tyr Pro Gly Ala Val Thr Val Ala Trp Lys Ala Asp Gly Ser Pro 
145                 150                 155                 160 


Val Lys Ala Gly Val Glu Thr Thr Lys Pro Ser Lys Gln Ser Asn Asn 
                165                 170                 175     


Lys Tyr Ala Ala Ser Ser Tyr Leu Ser Leu Thr Pro Glu Gln Trp Lys 
            180                 185                 190         


Ser His Arg Ser Tyr Ser Cys Gln Val Thr His Glu Gly Ser Thr Val 
        195                 200                 205             


Glu Lys Thr Val Ala Pro Thr Glu Cys Ser 
    210                 215             


<210>  336
<211>  217
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  L10 amino acid sequence

<400>  336

Gln Ser Ala Leu Thr Gln Pro Pro Ser Ala Ser Gly Ser Pro Gly Gln 
1               5                   10                  15      


Ser Val Thr Ser Ser Cys Thr Gly Thr Ser Ser Asp Val Gly Gly Tyr 
            20                  25                  30          


Asn Tyr Val Ser Trp Tyr Gln Gln Gln Pro Gly Lys Ala Pro Lys Leu 
        35                  40                  45              


Met Ile Tyr Glu Val Ser Lys Arg Pro Ser Gly Val Pro Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Lys Ser Gly Asn Thr Ala Ser Leu Thr Val Ser Gly Leu 
65                  70                  75                  80  


Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Phe Ser Ser Tyr Ala Gly Ser 
                85                  90                  95      


Asn Asn Phe Asp Val Phe Gly Thr Gly Thr Lys Val Thr Val Leu Gly 
            100                 105                 110         


Gln Pro Lys Ala Asn Pro Thr Val Thr Leu Phe Pro Pro Ser Ser Glu 
        115                 120                 125             


Glu Leu Gln Ala Asn Lys Ala Thr Leu Val Cys Leu Ile Ser Asp Phe 
    130                 135                 140                 


Tyr Pro Gly Ala Val Thr Val Ala Trp Lys Ala Asp Gly Ser Pro Val 
145                 150                 155                 160 


Lys Ala Gly Val Glu Thr Thr Lys Pro Ser Lys Gln Ser Asn Asn Lys 
                165                 170                 175     


Tyr Ala Ala Ser Ser Tyr Leu Ser Leu Thr Pro Glu Gln Trp Lys Ser 
            180                 185                 190         


His Arg Ser Tyr Ser Cys Gln Val Thr His Glu Gly Ser Thr Val Glu 
        195                 200                 205             


Lys Thr Val Ala Pro Thr Glu Cys Ser 
    210                 215         


<210>  337
<211>  218
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  L11 amino acid sequence

<400>  337

Gln Ser Val Leu Thr Gln Pro Pro Ser Val Ser Gly Ala Pro Gly Gln 
1               5                   10                  15      


Arg Val Thr Ile Ser Cys Thr Gly Ser Ser Ser Asn Ile Gly Ala Gly 
            20                  25                  30          


Tyr Asp Val His Trp Tyr Gln Gln Ser Pro Gly Thr Ala Pro Lys Leu 
        35                  40                  45              


Leu Ile Tyr Gly Asn Ser Asn Arg Pro Ser Gly Val Pro Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Thr Gly Leu 
65                  70                  75                  80  


Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Gln Ser Tyr Asp Asn Arg 
                85                  90                  95      


Leu Ser Asp Ser Val Val Ile Gly Gly Gly Thr Lys Leu Thr Val Gln 
            100                 105                 110         


Gly Gln Pro Lys Ala Asn Pro Thr Val Thr Leu Phe Pro Pro Ser Ser 
        115                 120                 125             


Glu Glu Leu Gln Ala Asn Lys Ala Thr Leu Val Cys Leu Ile Ser Asp 
    130                 135                 140                 


Phe Tyr Pro Gly Ala Val Thr Val Ala Trp Lys Ala Asp Gly Ser Pro 
145                 150                 155                 160 


Val Lys Ala Gly Val Glu Thr Thr Lys Pro Ser Lys Gln Ser Asn Asn 
                165                 170                 175     


Lys Tyr Ala Ala Ser Ser Tyr Leu Ser Leu Thr Pro Glu Gln Trp Lys 
            180                 185                 190         


Ser His Arg Ser Tyr Ser Cys Gln Val Thr His Glu Gly Ser Thr Val 
        195                 200                 205             


Glu Lys Thr Val Ala Pro Thr Glu Cys Ser 
    210                 215             


<210>  338
<211>  218
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  L12 amino acid sequence

<400>  338

Gln Ser Val Leu Thr Gln Pro Pro Ser Val Ser Gly Ala Pro Gly Gln 
1               5                   10                  15      


Arg Val Thr Ile Ser Cys Thr Gly Ser Arg Ser Asn Ile Gly Ala Gly 
            20                  25                  30          


Tyr Asp Val His Trp Tyr Gln Gln Leu Pro Arg Thr Ala Pro Lys Leu 
        35                  40                  45              


Leu Ile Tyr Asp Asn Ser Asn Arg Pro Ser Gly Val Pro Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Lys Ser Gly Ser Ser Ala Ser Leu Ala Ile Thr Gly Leu 
65                  70                  75                  80  


Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Gln Ser Tyr Asp Asn Ser 
                85                  90                  95      


Leu Ser Asp Ser Val Leu Ile Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 110         


Gly Gln Pro Lys Ala Asn Pro Thr Val Thr Leu Phe Pro Pro Ser Ser 
        115                 120                 125             


Glu Glu Leu Gln Ala Asn Lys Ala Thr Leu Val Cys Leu Ile Ser Asp 
    130                 135                 140                 


Phe Tyr Pro Gly Ala Val Thr Val Ala Trp Lys Ala Asp Gly Ser Pro 
145                 150                 155                 160 


Val Lys Ala Gly Val Glu Thr Thr Lys Pro Ser Lys Gln Ser Asn Asn 
                165                 170                 175     


Lys Tyr Ala Ala Ser Ser Tyr Leu Ser Leu Thr Pro Glu Gln Trp Lys 
            180                 185                 190         


Ser His Arg Ser Tyr Ser Cys Gln Val Thr His Glu Gly Ser Thr Val 
        195                 200                 205             


Glu Lys Thr Val Ala Pro Thr Glu Cys Ser 
    210                 215             


<210>  339
<211>  217
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  L13 amino acid sequence

<400>  339

Gln Ser Ala Leu Thr Gln Pro Pro Ser Ala Ser Gly Ser Pro Gly Gln 
1               5                   10                  15      


Ser Val Thr Ser Ser Cys Thr Gly Thr Ser Ser Asp Val Gly Gly Tyr 
            20                  25                  30          


Asn Tyr Val Ser Trp Tyr Gln Gln His Pro Gly Lys Ala Pro Lys Leu 
        35                  40                  45              


Met Ile Tyr Glu Val Ser Lys Arg Pro Ser Gly Val Pro Asp Trp Phe 
    50                  55                  60                  


Ser Gly Ser Lys Ser Gly Asn Thr Ala Ser Leu Thr Val Ser Gly Leu 
65                  70                  75                  80  


Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Tyr Asn Ser Tyr Ser Gly Ser 
                85                  90                  95      


Asn Asn Phe Asp Val Phe Gly Thr Gly Thr Lys Val Thr Val Leu Gly 
            100                 105                 110         


Gln Pro Lys Ala Asn Pro Thr Val Thr Leu Phe Pro Pro Ser Ser Glu 
        115                 120                 125             


Glu Leu Gln Ala Asn Lys Ala Thr Leu Val Cys Leu Ile Ser Asp Phe 
    130                 135                 140                 


Tyr Pro Gly Ala Val Thr Val Ala Trp Lys Ala Asp Gly Ser Pro Val 
145                 150                 155                 160 


Lys Ala Gly Val Glu Thr Thr Lys Pro Ser Lys Gln Ser Asn Asn Lys 
                165                 170                 175     


Tyr Ala Ala Ser Ser Tyr Leu Ser Leu Thr Pro Glu Gln Trp Lys Ser 
            180                 185                 190         


His Arg Ser Tyr Ser Cys Gln Val Thr His Glu Gly Ser Thr Val Glu 
        195                 200                 205             


Lys Thr Val Ala Pro Thr Glu Cys Ser 
    210                 215         


<210>  340
<211>  218
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  L14 amino acid sequence

<400>  340

Gln Ser Val Leu Thr Gln Pro Pro Ser Val Ser Gly Ala Pro Gly Gln 
1               5                   10                  15      


Arg Val Thr Ile Ser Cys Thr Gly Ser Ser Ser Asn Ile Gly Ala Gly 
            20                  25                  30          


Tyr Asp Val His Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu 
        35                  40                  45              


Leu Ile Tyr Gly Asn Ser Asn Arg Pro Ser Gly Val Pro Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Thr Gly Leu 
65                  70                  75                  80  


Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Gln Ser Tyr Asp Asn Arg 
                85                  90                  95      


Leu Ser Asp Ser Val Val Ile Gly Gly Gly Thr Lys Leu Thr Val Gln 
            100                 105                 110         


Gly Gln Pro Lys Ala Asn Pro Thr Val Thr Leu Phe Pro Pro Ser Ser 
        115                 120                 125             


Glu Glu Leu Gln Ala Asn Lys Ala Thr Leu Val Cys Leu Ile Ser Asp 
    130                 135                 140                 


Phe Tyr Pro Gly Ala Val Thr Val Ala Trp Lys Ala Asp Gly Ser Pro 
145                 150                 155                 160 


Val Lys Ala Gly Val Glu Thr Thr Lys Pro Ser Lys Gln Ser Asn Asn 
                165                 170                 175     


Lys Tyr Ala Ala Ser Ser Tyr Leu Ser Leu Thr Pro Glu Gln Trp Lys 
            180                 185                 190         


Ser His Arg Ser Tyr Ser Cys Gln Val Thr His Glu Gly Ser Thr Val 
        195                 200                 205             


Glu Lys Thr Val Ala Pro Thr Glu Cys Ser 
    210                 215             


<210>  341
<211>  217
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  L15 amino acid sequence

<400>  341

Gln Ser Val Leu Thr Gln Pro Pro Ser Val Ser Gly Ala Pro Gly Gln 
1               5                   10                  15      


Arg Val Thr Ile Ser Cys Thr Gly Ser Ser Ser Asn Ile Gly Ala Gly 
            20                  25                  30          


Tyr Asp Val His Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu 
        35                  40                  45              


Leu Ile Tyr Gly Asn Ser Asn Arg Pro Ser Gly Val Pro Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Thr Lys Phe 
65                  70                  75                  80  


Gln Ala Glu Asp Glu Ala Val Tyr Tyr Cys Gln Ser Tyr Gly Ser Gly 
                85                  90                  95      


Leu Ser Gly Val Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly 
            100                 105                 110         


Gln Pro Lys Ala Asn Pro Thr Val Thr Leu Phe Pro Pro Ser Ser Glu 
        115                 120                 125             


Glu Leu Gln Ala Asn Lys Ala Thr Leu Val Cys Leu Ile Ser Asp Phe 
    130                 135                 140                 


Tyr Pro Gly Ala Val Thr Val Ala Trp Lys Ala Asp Gly Ser Pro Val 
145                 150                 155                 160 


Lys Ala Gly Val Glu Thr Thr Lys Pro Ser Lys Gln Ser Asn Asn Lys 
                165                 170                 175     


Tyr Ala Ala Ser Ser Tyr Leu Ser Leu Thr Pro Glu Gln Trp Lys Ser 
            180                 185                 190         


His Arg Ser Tyr Ser Cys Gln Val Thr His Glu Gly Ser Thr Val Glu 
        195                 200                 205             


Lys Thr Val Ala Pro Thr Glu Cys Ser 
    210                 215         


<210>  342
<211>  215
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  L16 amino acid sequence

<400>  342

Gln Ser Val Leu Thr Gln Pro Pro Ser Val Ser Gly Ala Pro Gly Gln 
1               5                   10                  15      


Arg Val Thr Ile Ser Cys Thr Gly Ser Asn Ser Asn Ile Gly Ala Gly 
            20                  25                  30          


Phe Asp Val His Trp Tyr Gln Gln Leu Pro Gly Thr Val Pro Lys Leu 
        35                  40                  45              


Leu Ile Tyr Gly Asn Asn Asn Arg Pro Ser Gly Val Pro Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Thr Gly Leu 
65                  70                  75                  80  


Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Gln Ser Tyr Asp Ser Arg 
                85                  90                  95      


Leu Thr Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Gln Pro 
            100                 105                 110         


Lys Ala Asn Pro Thr Val Thr Leu Phe Pro Pro Ser Ser Glu Glu Leu 
        115                 120                 125             


Gln Ala Asn Lys Ala Thr Leu Val Cys Leu Ile Ser Asp Phe Tyr Pro 
    130                 135                 140                 


Gly Ala Val Thr Val Ala Trp Lys Ala Asp Gly Ser Pro Val Lys Ala 
145                 150                 155                 160 


Gly Val Glu Thr Thr Lys Pro Ser Lys Gln Ser Asn Asn Lys Tyr Ala 
                165                 170                 175     


Ala Ser Ser Tyr Leu Ser Leu Thr Pro Glu Gln Trp Lys Ser His Arg 
            180                 185                 190         


Ser Tyr Ser Cys Gln Val Thr His Glu Gly Ser Thr Val Glu Lys Thr 
        195                 200                 205             


Val Ala Pro Thr Glu Cys Ser 
    210                 215 


<210>  343
<211>  446
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  H9 amino acid sequence

<400>  343

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Pro Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asp Tyr 
            20                  25                  30          


Tyr Ile Asn Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Asn Pro Asn Asn Gly Gly Thr Asn Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Met Thr Arg Asp Thr Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Arg Arg Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Glu Arg Gly Gly Tyr Glu Asp Trp Phe Asp Pro Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val 
        115                 120                 125             


Phe Pro Leu Ala Pro Cys Ser Arg Ser Thr Ser Glu Ser Thr Ala Ala 
    130                 135                 140                 


Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser 
145                 150                 155                 160 


Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val 
                165                 170                 175     


Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro 
            180                 185                 190         


Ser Ser Asn Phe Gly Thr Gln Thr Tyr Thr Cys Asn Val Asp His Lys 
        195                 200                 205             


Pro Ser Asn Thr Lys Val Asp Lys Thr Val Glu Arg Lys Cys Cys Val 
    210                 215                 220                 


Glu Cys Pro Pro Cys Pro Ala Pro Pro Val Ala Gly Pro Ser Val Phe 
225                 230                 235                 240 


Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro 
                245                 250                 255     


Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val 
            260                 265                 270         


Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr 
        275                 280                 285             


Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Phe Arg Val Val Ser Val 
    290                 295                 300                 


Leu Thr Val Val His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys 
305                 310                 315                 320 


Lys Val Ser Asn Lys Gly Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser 
                325                 330                 335     


Lys Thr Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro 
            340                 345                 350         


Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val 
        355                 360                 365             


Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly 
    370                 375                 380                 


Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Met Leu Asp Ser Asp 
385                 390                 395                 400 


Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp 
                405                 410                 415     


Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His 
            420                 425                 430         


Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
        435                 440                 445     


<210>  344
<211>  446
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  H10 amino acid sequence

<400>  344

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asp Tyr 
            20                  25                  30          


Tyr Met Asn Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Asn Pro Asn Ser Gly Gly Thr Lys Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Met Thr Arg Asp Thr Ser Ile Arg Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Arg Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Glu Tyr Gly Gly Asn Ser Asp Trp Phe Asp Pro Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val 
        115                 120                 125             


Phe Pro Leu Ala Pro Cys Ser Arg Ser Thr Ser Glu Ser Thr Ala Ala 
    130                 135                 140                 


Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser 
145                 150                 155                 160 


Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val 
                165                 170                 175     


Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro 
            180                 185                 190         


Ser Ser Asn Phe Gly Thr Gln Thr Tyr Thr Cys Asn Val Asp His Lys 
        195                 200                 205             


Pro Ser Asn Thr Lys Val Asp Lys Thr Val Glu Arg Lys Cys Cys Val 
    210                 215                 220                 


Glu Cys Pro Pro Cys Pro Ala Pro Pro Val Ala Gly Pro Ser Val Phe 
225                 230                 235                 240 


Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro 
                245                 250                 255     


Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val 
            260                 265                 270         


Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr 
        275                 280                 285             


Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Phe Arg Val Val Ser Val 
    290                 295                 300                 


Leu Thr Val Val His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys 
305                 310                 315                 320 


Lys Val Ser Asn Lys Gly Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser 
                325                 330                 335     


Lys Thr Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro 
            340                 345                 350         


Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val 
        355                 360                 365             


Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly 
    370                 375                 380                 


Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Met Leu Asp Ser Asp 
385                 390                 395                 400 


Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp 
                405                 410                 415     


Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His 
            420                 425                 430         


Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
        435                 440                 445     


<210>  345
<211>  446
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  H11 amino acid sequence

<400>  345

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asp Tyr 
            20                  25                  30          


Tyr Met Asn Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Asn Pro Asn Ser Gly Gly Thr His Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Met Thr Arg Asp Thr Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Arg Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Glu Tyr Gly Gly Tyr Ser Asp Trp Phe Asp Pro Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val 
        115                 120                 125             


Phe Pro Leu Ala Pro Cys Ser Arg Ser Thr Ser Glu Ser Thr Ala Ala 
    130                 135                 140                 


Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser 
145                 150                 155                 160 


Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val 
                165                 170                 175     


Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro 
            180                 185                 190         


Ser Ser Asn Phe Gly Thr Gln Thr Tyr Thr Cys Asn Val Asp His Lys 
        195                 200                 205             


Pro Ser Asn Thr Lys Val Asp Lys Thr Val Glu Arg Lys Cys Cys Val 
    210                 215                 220                 


Glu Cys Pro Pro Cys Pro Ala Pro Pro Val Ala Gly Pro Ser Val Phe 
225                 230                 235                 240 


Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro 
                245                 250                 255     


Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val 
            260                 265                 270         


Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr 
        275                 280                 285             


Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Phe Arg Val Val Ser Val 
    290                 295                 300                 


Leu Thr Val Val His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys 
305                 310                 315                 320 


Lys Val Ser Asn Lys Gly Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser 
                325                 330                 335     


Lys Thr Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro 
            340                 345                 350         


Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val 
        355                 360                 365             


Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly 
    370                 375                 380                 


Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Met Leu Asp Ser Asp 
385                 390                 395                 400 


Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp 
                405                 410                 415     


Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His 
            420                 425                 430         


Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
        435                 440                 445     


<210>  346
<211>  446
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  H12 amino acid sequence

<400>  346

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asp Tyr 
            20                  25                  30          


Tyr Met Asn Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Asn Pro Asn Ser Gly Gly Thr Lys Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Met Thr Arg Asp Thr Ser Ile Arg Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Arg Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ser Arg Glu Tyr Gly Gly Asn Ser Asp Trp Phe Asp Pro Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val 
        115                 120                 125             


Phe Pro Leu Ala Pro Cys Ser Arg Ser Thr Ser Glu Ser Thr Ala Ala 
    130                 135                 140                 


Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser 
145                 150                 155                 160 


Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val 
                165                 170                 175     


Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro 
            180                 185                 190         


Ser Ser Asn Phe Gly Thr Gln Thr Tyr Thr Cys Asn Val Asp His Lys 
        195                 200                 205             


Pro Ser Asn Thr Lys Val Asp Lys Thr Val Glu Arg Lys Cys Cys Val 
    210                 215                 220                 


Glu Cys Pro Pro Cys Pro Ala Pro Pro Val Ala Gly Pro Ser Val Phe 
225                 230                 235                 240 


Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro 
                245                 250                 255     


Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val 
            260                 265                 270         


Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr 
        275                 280                 285             


Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Phe Arg Val Val Ser Val 
    290                 295                 300                 


Leu Thr Val Val His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys 
305                 310                 315                 320 


Lys Val Ser Asn Lys Gly Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser 
                325                 330                 335     


Lys Thr Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro 
            340                 345                 350         


Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val 
        355                 360                 365             


Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly 
    370                 375                 380                 


Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Met Leu Asp Ser Asp 
385                 390                 395                 400 


Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp 
                405                 410                 415     


Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His 
            420                 425                 430         


Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
        435                 440                 445     


<210>  347
<211>  446
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  H13 amino acid sequence

<400>  347

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asp Tyr 
            20                  25                  30          


Tyr Ile Asn Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Asn Pro Asn Ser Gly Gly Ser Ser Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Met Thr Arg Asp Thr Ser Ile Ser Thr Ala His 
65                  70                  75                  80  


Met Glu Leu Ile Arg Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Glu Arg Gly Gly Ile Glu Asp Trp Phe Asp Pro Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val 
        115                 120                 125             


Phe Pro Leu Ala Pro Cys Ser Arg Ser Thr Ser Glu Ser Thr Ala Ala 
    130                 135                 140                 


Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser 
145                 150                 155                 160 


Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val 
                165                 170                 175     


Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro 
            180                 185                 190         


Ser Ser Asn Phe Gly Thr Gln Thr Tyr Thr Cys Asn Val Asp His Lys 
        195                 200                 205             


Pro Ser Asn Thr Lys Val Asp Lys Thr Val Glu Arg Lys Cys Cys Val 
    210                 215                 220                 


Glu Cys Pro Pro Cys Pro Ala Pro Pro Val Ala Gly Pro Ser Val Phe 
225                 230                 235                 240 


Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro 
                245                 250                 255     


Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val 
            260                 265                 270         


Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr 
        275                 280                 285             


Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Phe Arg Val Val Ser Val 
    290                 295                 300                 


Leu Thr Val Val His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys 
305                 310                 315                 320 


Lys Val Ser Asn Lys Gly Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser 
                325                 330                 335     


Lys Thr Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro 
            340                 345                 350         


Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val 
        355                 360                 365             


Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly 
    370                 375                 380                 


Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Met Leu Asp Ser Asp 
385                 390                 395                 400 


Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp 
                405                 410                 415     


Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His 
            420                 425                 430         


Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
        435                 440                 445     


<210>  348
<211>  446
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  H14 amino acid sequence

<400>  348

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asp Tyr 
            20                  25                  30          


Tyr Ile Asn Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Asn Pro Asn Ser Gly Gly Thr Asp Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Met Thr Arg Asp Thr Ser Ile Arg Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Asn Arg Leu Thr Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Glu Tyr Gly Gly Tyr Glu Asp Trp Phe Asp Pro Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val 
        115                 120                 125             


Phe Pro Leu Ala Pro Cys Ser Arg Ser Thr Ser Glu Ser Thr Ala Ala 
    130                 135                 140                 


Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser 
145                 150                 155                 160 


Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val 
                165                 170                 175     


Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro 
            180                 185                 190         


Ser Ser Asn Phe Gly Thr Gln Thr Tyr Thr Cys Asn Val Asp His Lys 
        195                 200                 205             


Pro Ser Asn Thr Lys Val Asp Lys Thr Val Glu Arg Lys Cys Cys Val 
    210                 215                 220                 


Glu Cys Pro Pro Cys Pro Ala Pro Pro Val Ala Gly Pro Ser Val Phe 
225                 230                 235                 240 


Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro 
                245                 250                 255     


Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val 
            260                 265                 270         


Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr 
        275                 280                 285             


Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Phe Arg Val Val Ser Val 
    290                 295                 300                 


Leu Thr Val Val His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys 
305                 310                 315                 320 


Lys Val Ser Asn Lys Gly Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser 
                325                 330                 335     


Lys Thr Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro 
            340                 345                 350         


Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val 
        355                 360                 365             


Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly 
    370                 375                 380                 


Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Met Leu Asp Ser Asp 
385                 390                 395                 400 


Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp 
                405                 410                 415     


Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His 
            420                 425                 430         


Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
        435                 440                 445     


