
                                SEQUENCE LISTING

<110> Vignali, Dario AA
      Collison, Lauren W.

<120> Methods and Compositions for Modulating
  the Activity of the Interleukin-35 Receptor Complex
  

<130> 044158/397057

<160> 6

<170> FastSEQ for Windows Version 4.0

<210> 1
<211> 3242
<212> DNA
<213> Homo sapiens

<220> 
<221> CDS            
<222> (256)...(3010)

<220> 
<221> misc_feature   
<222> (0)...(0)
<223> cDNA for gp130 (GenBank Accession No. NM_002184.2)

<400> 1
gagcagccaa aaggcccgcg gagtcgcgct gggccgcccc ggcgcagctg aaccgggggc 60
cgcgcctgcc aggccgacgg gtctggccca gcctggcgcc aaggggttcg tgcgctgtgg 120
agacgcggag ggtcgaggcg gcgcggcctg agtgaaaccc aatggaaaaa gcatgacatt 180
tagaagtaga agacttagct tcaaatccct actccttcac ttactaattt tgtgatttgg 240
aaatatccgc gcaag atg ttg acg ttg cag act tgg cta gtg caa gcc ttg  291
                 Met Leu Thr Leu Gln Thr Trp Leu Val Gln Ala Leu
                  1               5                   10
 
ttt att ttc ctc acc act gaa tct aca ggt gaa ctt cta gat cca tgt   339
Phe Ile Phe Leu Thr Thr Glu Ser Thr Gly Glu Leu Leu Asp Pro Cys
         15                  20                  25
 
ggt tat atc agt cct gaa tct cca gtt gta caa ctt cat tct aat ttc   387
Gly Tyr Ile Ser Pro Glu Ser Pro Val Val Gln Leu His Ser Asn Phe
     30                  35                  40
 
act gca gtt tgt gtg cta aag gaa aaa tgt atg gat tat ttt cat gta   435
Thr Ala Val Cys Val Leu Lys Glu Lys Cys Met Asp Tyr Phe His Val
 45                  50                  55                  60
 
aat gct aat tac att gtc tgg aaa aca aac cat ttt act att cct aag   483
Asn Ala Asn Tyr Ile Val Trp Lys Thr Asn His Phe Thr Ile Pro Lys
                 65                  70                  75
 
gag caa tat act atc ata aac aga aca gca tcc agt gtc acc ttt aca   531
Glu Gln Tyr Thr Ile Ile Asn Arg Thr Ala Ser Ser Val Thr Phe Thr
             80                  85                  90
 
gat ata gct tca tta aat att cag ctc act tgc aac att ctt aca ttc   579
Asp Ile Ala Ser Leu Asn Ile Gln Leu Thr Cys Asn Ile Leu Thr Phe
         95                 100                 105
 
gga cag ctt gaa cag aat gtt tat gga atc aca ata att tca ggc ttg   627
Gly Gln Leu Glu Gln Asn Val Tyr Gly Ile Thr Ile Ile Ser Gly Leu
    110                 115                 120
 
cct cca gaa aaa cct aaa aat ttg agt tgc att gtg aac gag ggg aag   675
Pro Pro Glu Lys Pro Lys Asn Leu Ser Cys Ile Val Asn Glu Gly Lys
125                 130                 135                 140
 
aaa atg agg tgt gag tgg gat ggt gga agg gaa aca cac ttg gag aca   723
Lys Met Arg Cys Glu Trp Asp Gly Gly Arg Glu Thr His Leu Glu Thr
                145                 150                 155
 
aac ttc act tta aaa tct gaa tgg gca aca cac aag ttt gct gat tgc   771
Asn Phe Thr Leu Lys Ser Glu Trp Ala Thr His Lys Phe Ala Asp Cys
            160                 165                 170
 
aaa gca aaa cgt gac acc ccc acc tca tgc act gtt gat tat tct act   819
Lys Ala Lys Arg Asp Thr Pro Thr Ser Cys Thr Val Asp Tyr Ser Thr
        175                 180                 185
 
gtg tat ttt gtc aac att gaa gtc tgg gta gaa gca gag aat gcc ctt   867
Val Tyr Phe Val Asn Ile Glu Val Trp Val Glu Ala Glu Asn Ala Leu
    190                 195                 200
 
ggg aag gtt aca tca gat cat atc aat ttt gat cct gta tat aaa gtg   915
Gly Lys Val Thr Ser Asp His Ile Asn Phe Asp Pro Val Tyr Lys Val
205                 210                 215                 220
 
aag ccc aat ccg cca cat aat tta tca gtg atc aac tca gag gaa ctg   963
Lys Pro Asn Pro Pro His Asn Leu Ser Val Ile Asn Ser Glu Glu Leu
                225                 230                 235
 
tct agt atc tta aaa ttg aca tgg acc aac cca agt att aag agt gtt   1011
Ser Ser Ile Leu Lys Leu Thr Trp Thr Asn Pro Ser Ile Lys Ser Val
            240                 245                 250
 
ata ata cta aaa tat aac att caa tat agg acc aaa gat gcc tca act   1059
Ile Ile Leu Lys Tyr Asn Ile Gln Tyr Arg Thr Lys Asp Ala Ser Thr
        255                 260                 265
 
tgg agc cag att cct cct gaa gac aca gca tcc acc cga tct tca ttc   1107
Trp Ser Gln Ile Pro Pro Glu Asp Thr Ala Ser Thr Arg Ser Ser Phe
    270                 275                 280
 
act gtc caa gac ctt aaa cct ttt aca gaa tat gtg ttt agg att cgc   1155
Thr Val Gln Asp Leu Lys Pro Phe Thr Glu Tyr Val Phe Arg Ile Arg
285                 290                 295                 300
 
tgt atg aag gaa gat ggt aag gga tac tgg agt gac tgg agt gaa gaa   1203
Cys Met Lys Glu Asp Gly Lys Gly Tyr Trp Ser Asp Trp Ser Glu Glu
                305                 310                 315
 
gca agt ggg atc acc tat gaa gat aga cca tct aaa gca cca agt ttc   1251
Ala Ser Gly Ile Thr Tyr Glu Asp Arg Pro Ser Lys Ala Pro Ser Phe
            320                 325                 330
 
tgg tat aaa ata gat cca tcc cat act caa ggc tac aga act gta caa   1299
Trp Tyr Lys Ile Asp Pro Ser His Thr Gln Gly Tyr Arg Thr Val Gln
        335                 340                 345
 
ctc gtg tgg aag aca ttg cct cct ttt gaa gcc aat gga aaa atc ttg   1347
Leu Val Trp Lys Thr Leu Pro Pro Phe Glu Ala Asn Gly Lys Ile Leu
    350                 355                 360
 
gat tat gaa gtg act ctc aca aga tgg aaa tca cat tta caa aat tac   1395
Asp Tyr Glu Val Thr Leu Thr Arg Trp Lys Ser His Leu Gln Asn Tyr
365                 370                 375                 380
 
aca gtt aat gcc aca aaa ctg aca gta aat ctc aca aat gat cgc tat   1443
Thr Val Asn Ala Thr Lys Leu Thr Val Asn Leu Thr Asn Asp Arg Tyr
                385                 390                 395
 
cta gca acc cta aca gta aga aat ctt gtt ggc aaa tca gat gca gct   1491
Leu Ala Thr Leu Thr Val Arg Asn Leu Val Gly Lys Ser Asp Ala Ala
            400                 405                 410
 
gtt tta act atc cct gcc tgt gac ttt caa gct act cac cct gta atg   1539
Val Leu Thr Ile Pro Ala Cys Asp Phe Gln Ala Thr His Pro Val Met
        415                 420                 425
 
gat ctt aaa gca ttc ccc aaa gat aac atg ctt tgg gtg gaa tgg act   1587
Asp Leu Lys Ala Phe Pro Lys Asp Asn Met Leu Trp Val Glu Trp Thr
    430                 435                 440
 
act cca agg gaa tct gta aag aaa tat ata ctt gag tgg tgt gtg tta   1635
Thr Pro Arg Glu Ser Val Lys Lys Tyr Ile Leu Glu Trp Cys Val Leu
445                 450                 455                 460
 
tca gat aaa gca ccc tgt atc aca gac tgg caa caa gaa gat ggt acc   1683
Ser Asp Lys Ala Pro Cys Ile Thr Asp Trp Gln Gln Glu Asp Gly Thr
                465                 470                 475
 
gtg cat cgc acc tat tta aga ggg aac tta gca gag agc aaa tgc tat   1731
Val His Arg Thr Tyr Leu Arg Gly Asn Leu Ala Glu Ser Lys Cys Tyr
            480                 485                 490
 
ttg ata aca gtt act cca gta tat gct gat gga cca gga agc cct gaa   1779
Leu Ile Thr Val Thr Pro Val Tyr Ala Asp Gly Pro Gly Ser Pro Glu
        495                 500                 505
 
tcc ata aag gca tac ctt aaa caa gct cca cct tcc aaa gga cct act   1827
Ser Ile Lys Ala Tyr Leu Lys Gln Ala Pro Pro Ser Lys Gly Pro Thr
    510                 515                 520
 
gtt cgg aca aaa aaa gta ggg aaa aac gaa gct gtc tta gag tgg gac   1875
Val Arg Thr Lys Lys Val Gly Lys Asn Glu Ala Val Leu Glu Trp Asp
525                 530                 535                 540
 
caa ctt cct gtt gat gtt cag aat gga ttt atc aga aat tat act ata   1923
Gln Leu Pro Val Asp Val Gln Asn Gly Phe Ile Arg Asn Tyr Thr Ile
                545                 550                 555
 
ttt tat aga acc atc att gga aat gaa act gct gtg aat gtg gat tct   1971
Phe Tyr Arg Thr Ile Ile Gly Asn Glu Thr Ala Val Asn Val Asp Ser
            560                 565                 570
 
tcc cac aca gaa tat aca ttg tcc tct ttg act agt gac aca ttg tac   2019
Ser His Thr Glu Tyr Thr Leu Ser Ser Leu Thr Ser Asp Thr Leu Tyr
        575                 580                 585
 
atg gta cga atg gca gca tac aca gat gaa ggt ggg aag gat ggt cca   2067
Met Val Arg Met Ala Ala Tyr Thr Asp Glu Gly Gly Lys Asp Gly Pro
    590                 595                 600
 
gaa ttc act ttt act acc cca aag ttt gct caa gga gaa att gaa gcc   2115
Glu Phe Thr Phe Thr Thr Pro Lys Phe Ala Gln Gly Glu Ile Glu Ala
605                 610                 615                 620
 
ata gtc gtg cct gtt tgc tta gca ttc cta ttg aca act ctt ctg gga   2163
Ile Val Val Pro Val Cys Leu Ala Phe Leu Leu Thr Thr Leu Leu Gly
                625                 630                 635
 
gtg ctg ttc tgc ttt aat aag cga gac cta att aaa aaa cac atc tgg   2211
Val Leu Phe Cys Phe Asn Lys Arg Asp Leu Ile Lys Lys His Ile Trp
            640                 645                 650
 
cct aat gtt cca gat cct tca aag agt cat att gcc cag tgg tca cct   2259
Pro Asn Val Pro Asp Pro Ser Lys Ser His Ile Ala Gln Trp Ser Pro
        655                 660                 665
 
cac act cct cca agg cac aat ttt aat tca aaa gat caa atg tat tca   2307
His Thr Pro Pro Arg His Asn Phe Asn Ser Lys Asp Gln Met Tyr Ser
    670                 675                 680
 
gat ggc aat ttc act gat gta agt gtt gtg gaa ata gaa gca aat gac   2355
Asp Gly Asn Phe Thr Asp Val Ser Val Val Glu Ile Glu Ala Asn Asp
685                 690                 695                 700
 
aaa aag cct ttt cca gaa gat ctg aaa tca ttg gac ctg ttc aaa aag   2403
Lys Lys Pro Phe Pro Glu Asp Leu Lys Ser Leu Asp Leu Phe Lys Lys
                705                 710                 715
 
gaa aaa att aat act gaa gga cac agc agt ggt att ggg ggg tct tca   2451
Glu Lys Ile Asn Thr Glu Gly His Ser Ser Gly Ile Gly Gly Ser Ser
            720                 725                 730
 
tgc atg tca tct tct agg cca agc att tct agc agt gat gaa aat gaa   2499
Cys Met Ser Ser Ser Arg Pro Ser Ile Ser Ser Ser Asp Glu Asn Glu
        735                 740                 745
 
tct tca caa aac act tcg agc act gtc cag tat tct acc gtg gta cac   2547
Ser Ser Gln Asn Thr Ser Ser Thr Val Gln Tyr Ser Thr Val Val His
    750                 755                 760
 
agt ggc tac aga cac caa gtt ccg tca gtc caa gtc ttc tca aga tcc   2595
Ser Gly Tyr Arg His Gln Val Pro Ser Val Gln Val Phe Ser Arg Ser
765                 770                 775                 780
 
gag tct acc cag ccc ttg tta gat tca gag gag cgg cca gaa gat cta   2643
Glu Ser Thr Gln Pro Leu Leu Asp Ser Glu Glu Arg Pro Glu Asp Leu
                785                 790                 795
 
caa tta gta gat cat gta gat ggc ggt gat ggt att ttg ccc agg caa   2691
Gln Leu Val Asp His Val Asp Gly Gly Asp Gly Ile Leu Pro Arg Gln
            800                 805                 810
 
cag tac ttc aaa cag aac tgc agt cag cat gaa tcc agt cca gat att   2739
Gln Tyr Phe Lys Gln Asn Cys Ser Gln His Glu Ser Ser Pro Asp Ile
        815                 820                 825
 
tca cat ttt gaa agg tca aag caa gtt tca tca gtc aat gag gaa gat   2787
Ser His Phe Glu Arg Ser Lys Gln Val Ser Ser Val Asn Glu Glu Asp
    830                 835                 840
 
ttt gtt aga ctt aaa cag cag att tca gat cat att tca caa tcc tgt   2835
Phe Val Arg Leu Lys Gln Gln Ile Ser Asp His Ile Ser Gln Ser Cys
845                 850                 855                 860
 
gga tct ggg caa atg aaa atg ttt cag gaa gtt tct gca gca gat gct   2883
Gly Ser Gly Gln Met Lys Met Phe Gln Glu Val Ser Ala Ala Asp Ala
                865                 870                 875
 
ttt ggt cca ggt act gag gga caa gta gaa aga ttt gaa aca gtt ggc   2931
Phe Gly Pro Gly Thr Glu Gly Gln Val Glu Arg Phe Glu Thr Val Gly
            880                 885                 890
 
atg gag gct gcg act gat gaa ggc atg cct aaa agt tac tta cca cag   2979
Met Glu Ala Ala Thr Asp Glu Gly Met Pro Lys Ser Tyr Leu Pro Gln
        895                 900                 905
 
act gta cgg caa ggc ggc tac atg cct cag t gaaggactag tagttcctgc   3030
Thr Val Arg Gln Gly Gly Tyr Met Pro Gln
    910                 915
 
tacaacttca gcagtaccta taaagtaaag ctaaaatgat tttatctgtg aattcagatt 3090
ttaaaaagtc ttcactctct gaagatgatc atttgccctt aaggacaaaa atgaactgaa 3150
gtttcacatg agctatttcc attccagaat atctgggatt ctactttaag cactacataa 3210
actgacttta tcctcagaaa aaaaaaaaaa aa                               3242

<210> 2
<211> 2757
<212> DNA
<213> Homo sapiens

<220> 
<221> misc_feature   
<222> (0)...(0)
<223> gp130 coding region

<220> 
<221> CDS            
<222> (1)...(2757)

<400> 2
atg ttg acg ttg cag act tgg cta gtg caa gcc ttg ttt att ttc ctc   48
Met Leu Thr Leu Gln Thr Trp Leu Val Gln Ala Leu Phe Ile Phe Leu
 1               5                   10                  15
 
acc act gaa tct aca ggt gaa ctt cta gat cca tgt ggt tat atc agt   96
Thr Thr Glu Ser Thr Gly Glu Leu Leu Asp Pro Cys Gly Tyr Ile Ser
             20                  25                  30
 
cct gaa tct cca gtt gta caa ctt cat tct aat ttc act gca gtt tgt   144
Pro Glu Ser Pro Val Val Gln Leu His Ser Asn Phe Thr Ala Val Cys
         35                  40                  45
 
gtg cta aag gaa aaa tgt atg gat tat ttt cat gta aat gct aat tac   192
Val Leu Lys Glu Lys Cys Met Asp Tyr Phe His Val Asn Ala Asn Tyr
     50                  55                  60
 
att gtc tgg aaa aca aac cat ttt act att cct aag gag caa tat act   240
Ile Val Trp Lys Thr Asn His Phe Thr Ile Pro Lys Glu Gln Tyr Thr
 65                  70                  75                  80
 
atc ata aac aga aca gca tcc agt gtc acc ttt aca gat ata gct tca   288
Ile Ile Asn Arg Thr Ala Ser Ser Val Thr Phe Thr Asp Ile Ala Ser
                 85                  90                  95
 
tta aat att cag ctc act tgc aac att ctt aca ttc gga cag ctt gaa   336
Leu Asn Ile Gln Leu Thr Cys Asn Ile Leu Thr Phe Gly Gln Leu Glu
            100                 105                 110
 
cag aat gtt tat gga atc aca ata att tca ggc ttg cct cca gaa aaa   384
Gln Asn Val Tyr Gly Ile Thr Ile Ile Ser Gly Leu Pro Pro Glu Lys
        115                 120                 125
 
cct aaa aat ttg agt tgc att gtg aac gag ggg aag aaa atg agg tgt   432
Pro Lys Asn Leu Ser Cys Ile Val Asn Glu Gly Lys Lys Met Arg Cys
    130                 135                 140
 
gag tgg gat ggt gga agg gaa aca cac ttg gag aca aac ttc act tta   480
Glu Trp Asp Gly Gly Arg Glu Thr His Leu Glu Thr Asn Phe Thr Leu
145                 150                 155                 160
 
aaa tct gaa tgg gca aca cac aag ttt gct gat tgc aaa gca aaa cgt   528
Lys Ser Glu Trp Ala Thr His Lys Phe Ala Asp Cys Lys Ala Lys Arg
                165                 170                 175
 
gac acc ccc acc tca tgc act gtt gat tat tct act gtg tat ttt gtc   576
Asp Thr Pro Thr Ser Cys Thr Val Asp Tyr Ser Thr Val Tyr Phe Val
            180                 185                 190
 
aac att gaa gtc tgg gta gaa gca gag aat gcc ctt ggg aag gtt aca   624
Asn Ile Glu Val Trp Val Glu Ala Glu Asn Ala Leu Gly Lys Val Thr
        195                 200                 205
 
tca gat cat atc aat ttt gat cct gta tat aaa gtg aag ccc aat ccg   672
Ser Asp His Ile Asn Phe Asp Pro Val Tyr Lys Val Lys Pro Asn Pro
    210                 215                 220
 
cca cat aat tta tca gtg atc aac tca gag gaa ctg tct agt atc tta   720
Pro His Asn Leu Ser Val Ile Asn Ser Glu Glu Leu Ser Ser Ile Leu
225                 230                 235                 240
 
aaa ttg aca tgg acc aac cca agt att aag agt gtt ata ata cta aaa   768
Lys Leu Thr Trp Thr Asn Pro Ser Ile Lys Ser Val Ile Ile Leu Lys
                245                 250                 255
 
tat aac att caa tat agg acc aaa gat gcc tca act tgg agc cag att   816
Tyr Asn Ile Gln Tyr Arg Thr Lys Asp Ala Ser Thr Trp Ser Gln Ile
            260                 265                 270
 
cct cct gaa gac aca gca tcc acc cga tct tca ttc act gtc caa gac   864
Pro Pro Glu Asp Thr Ala Ser Thr Arg Ser Ser Phe Thr Val Gln Asp
        275                 280                 285
 
ctt aaa cct ttt aca gaa tat gtg ttt agg att cgc tgt atg aag gaa   912
Leu Lys Pro Phe Thr Glu Tyr Val Phe Arg Ile Arg Cys Met Lys Glu
    290                 295                 300
 
gat ggt aag gga tac tgg agt gac tgg agt gaa gaa gca agt ggg atc   960
Asp Gly Lys Gly Tyr Trp Ser Asp Trp Ser Glu Glu Ala Ser Gly Ile
305                 310                 315                 320
 
acc tat gaa gat aga cca tct aaa gca cca agt ttc tgg tat aaa ata   1008
Thr Tyr Glu Asp Arg Pro Ser Lys Ala Pro Ser Phe Trp Tyr Lys Ile
                325                 330                 335
 
gat cca tcc cat act caa ggc tac aga act gta caa ctc gtg tgg aag   1056
Asp Pro Ser His Thr Gln Gly Tyr Arg Thr Val Gln Leu Val Trp Lys
            340                 345                 350
 
aca ttg cct cct ttt gaa gcc aat gga aaa atc ttg gat tat gaa gtg   1104
Thr Leu Pro Pro Phe Glu Ala Asn Gly Lys Ile Leu Asp Tyr Glu Val
        355                 360                 365
 
act ctc aca aga tgg aaa tca cat tta caa aat tac aca gtt aat gcc   1152
Thr Leu Thr Arg Trp Lys Ser His Leu Gln Asn Tyr Thr Val Asn Ala
    370                 375                 380
 
aca aaa ctg aca gta aat ctc aca aat gat cgc tat cta gca acc cta   1200
Thr Lys Leu Thr Val Asn Leu Thr Asn Asp Arg Tyr Leu Ala Thr Leu
385                 390                 395                 400
 
aca gta aga aat ctt gtt ggc aaa tca gat gca gct gtt tta act atc   1248
Thr Val Arg Asn Leu Val Gly Lys Ser Asp Ala Ala Val Leu Thr Ile
                405                 410                 415
 
cct gcc tgt gac ttt caa gct act cac cct gta atg gat ctt aaa gca   1296
Pro Ala Cys Asp Phe Gln Ala Thr His Pro Val Met Asp Leu Lys Ala
            420                 425                 430
 
ttc ccc aaa gat aac atg ctt tgg gtg gaa tgg act act cca agg gaa   1344
Phe Pro Lys Asp Asn Met Leu Trp Val Glu Trp Thr Thr Pro Arg Glu
        435                 440                 445
 
tct gta aag aaa tat ata ctt gag tgg tgt gtg tta tca gat aaa gca   1392
Ser Val Lys Lys Tyr Ile Leu Glu Trp Cys Val Leu Ser Asp Lys Ala
    450                 455                 460
 
ccc tgt atc aca gac tgg caa caa gaa gat ggt acc gtg cat cgc acc   1440
Pro Cys Ile Thr Asp Trp Gln Gln Glu Asp Gly Thr Val His Arg Thr
465                 470                 475                 480
 
tat tta aga ggg aac tta gca gag agc aaa tgc tat ttg ata aca gtt   1488
Tyr Leu Arg Gly Asn Leu Ala Glu Ser Lys Cys Tyr Leu Ile Thr Val
                485                 490                 495
 
act cca gta tat gct gat gga cca gga agc cct gaa tcc ata aag gca   1536
Thr Pro Val Tyr Ala Asp Gly Pro Gly Ser Pro Glu Ser Ile Lys Ala
            500                 505                 510
 
tac ctt aaa caa gct cca cct tcc aaa gga cct act gtt cgg aca aaa   1584
Tyr Leu Lys Gln Ala Pro Pro Ser Lys Gly Pro Thr Val Arg Thr Lys
        515                 520                 525
 
aaa gta ggg aaa aac gaa gct gtc tta gag tgg gac caa ctt cct gtt   1632
Lys Val Gly Lys Asn Glu Ala Val Leu Glu Trp Asp Gln Leu Pro Val
    530                 535                 540
 
gat gtt cag aat gga ttt atc aga aat tat act ata ttt tat aga acc   1680
Asp Val Gln Asn Gly Phe Ile Arg Asn Tyr Thr Ile Phe Tyr Arg Thr
545                 550                 555                 560
 
atc att gga aat gaa act gct gtg aat gtg gat tct tcc cac aca gaa   1728
Ile Ile Gly Asn Glu Thr Ala Val Asn Val Asp Ser Ser His Thr Glu
                565                 570                 575
 
tat aca ttg tcc tct ttg act agt gac aca ttg tac atg gta cga atg   1776
Tyr Thr Leu Ser Ser Leu Thr Ser Asp Thr Leu Tyr Met Val Arg Met
            580                 585                 590
 
gca gca tac aca gat gaa ggt ggg aag gat ggt cca gaa ttc act ttt   1824
Ala Ala Tyr Thr Asp Glu Gly Gly Lys Asp Gly Pro Glu Phe Thr Phe
        595                 600                 605
 
act acc cca aag ttt gct caa gga gaa att gaa gcc ata gtc gtg cct   1872
Thr Thr Pro Lys Phe Ala Gln Gly Glu Ile Glu Ala Ile Val Val Pro
    610                 615                 620
 
gtt tgc tta gca ttc cta ttg aca act ctt ctg gga gtg ctg ttc tgc   1920
Val Cys Leu Ala Phe Leu Leu Thr Thr Leu Leu Gly Val Leu Phe Cys
625                 630                 635                 640
 
ttt aat aag cga gac cta att aaa aaa cac atc tgg cct aat gtt cca   1968
Phe Asn Lys Arg Asp Leu Ile Lys Lys His Ile Trp Pro Asn Val Pro
                645                 650                 655
 
gat cct tca aag agt cat att gcc cag tgg tca cct cac act cct cca   2016
Asp Pro Ser Lys Ser His Ile Ala Gln Trp Ser Pro His Thr Pro Pro
            660                 665                 670
 
agg cac aat ttt aat tca aaa gat caa atg tat tca gat ggc aat ttc   2064
Arg His Asn Phe Asn Ser Lys Asp Gln Met Tyr Ser Asp Gly Asn Phe
        675                 680                 685
 
act gat gta agt gtt gtg gaa ata gaa gca aat gac aaa aag cct ttt   2112
Thr Asp Val Ser Val Val Glu Ile Glu Ala Asn Asp Lys Lys Pro Phe
    690                 695                 700
 
cca gaa gat ctg aaa tca ttg gac ctg ttc aaa aag gaa aaa att aat   2160
Pro Glu Asp Leu Lys Ser Leu Asp Leu Phe Lys Lys Glu Lys Ile Asn
705                 710                 715                 720
 
act gaa gga cac agc agt ggt att ggg ggg tct tca tgc atg tca tct   2208
Thr Glu Gly His Ser Ser Gly Ile Gly Gly Ser Ser Cys Met Ser Ser
                725                 730                 735
 
tct agg cca agc att tct agc agt gat gaa aat gaa tct tca caa aac   2256
Ser Arg Pro Ser Ile Ser Ser Ser Asp Glu Asn Glu Ser Ser Gln Asn
            740                 745                 750
 
act tcg agc act gtc cag tat tct acc gtg gta cac agt ggc tac aga   2304
Thr Ser Ser Thr Val Gln Tyr Ser Thr Val Val His Ser Gly Tyr Arg
        755                 760                 765
 
cac caa gtt ccg tca gtc caa gtc ttc tca aga tcc gag tct acc cag   2352
His Gln Val Pro Ser Val Gln Val Phe Ser Arg Ser Glu Ser Thr Gln
    770                 775                 780
 
ccc ttg tta gat tca gag gag cgg cca gaa gat cta caa tta gta gat   2400
Pro Leu Leu Asp Ser Glu Glu Arg Pro Glu Asp Leu Gln Leu Val Asp
785                 790                 795                 800
 
cat gta gat ggc ggt gat ggt att ttg ccc agg caa cag tac ttc aaa   2448
His Val Asp Gly Gly Asp Gly Ile Leu Pro Arg Gln Gln Tyr Phe Lys
                805                 810                 815
 
cag aac tgc agt cag cat gaa tcc agt cca gat att tca cat ttt gaa   2496
Gln Asn Cys Ser Gln His Glu Ser Ser Pro Asp Ile Ser His Phe Glu
            820                 825                 830
 
agg tca aag caa gtt tca tca gtc aat gag gaa gat ttt gtt aga ctt   2544
Arg Ser Lys Gln Val Ser Ser Val Asn Glu Glu Asp Phe Val Arg Leu
        835                 840                 845
 
aaa cag cag att tca gat cat att tca caa tcc tgt gga tct ggg caa   2592
Lys Gln Gln Ile Ser Asp His Ile Ser Gln Ser Cys Gly Ser Gly Gln
    850                 855                 860
 
atg aaa atg ttt cag gaa gtt tct gca gca gat gct ttt ggt cca ggt   2640
Met Lys Met Phe Gln Glu Val Ser Ala Ala Asp Ala Phe Gly Pro Gly
865                 870                 875                 880
 
act gag gga caa gta gaa aga ttt gaa aca gtt ggc atg gag gct gcg   2688
Thr Glu Gly Gln Val Glu Arg Phe Glu Thr Val Gly Met Glu Ala Ala
                885                 890                 895
 
act gat gaa ggc atg cct aaa agt tac tta cca cag act gta cgg caa   2736
Thr Asp Glu Gly Met Pro Lys Ser Tyr Leu Pro Gln Thr Val Arg Gln
            900                 905                 910
 
ggc ggc tac atg cct cag tga                                       2757
Gly Gly Tyr Met Pro Gln  *
        915
 

<210> 3
<211> 918
<212> PRT
<213> Homo Sapiens

<400> 3
Met Leu Thr Leu Gln Thr Trp Leu Val Gln Ala Leu Phe Ile Phe Leu
 1               5                  10                  15      
Thr Thr Glu Ser Thr Gly Glu Leu Leu Asp Pro Cys Gly Tyr Ile Ser
            20                  25                  30          
Pro Glu Ser Pro Val Val Gln Leu His Ser Asn Phe Thr Ala Val Cys
        35                  40                  45              
Val Leu Lys Glu Lys Cys Met Asp Tyr Phe His Val Asn Ala Asn Tyr
    50                  55                  60                  
Ile Val Trp Lys Thr Asn His Phe Thr Ile Pro Lys Glu Gln Tyr Thr
65                  70                  75                  80  
Ile Ile Asn Arg Thr Ala Ser Ser Val Thr Phe Thr Asp Ile Ala Ser
                85                  90                  95      
Leu Asn Ile Gln Leu Thr Cys Asn Ile Leu Thr Phe Gly Gln Leu Glu
            100                 105                 110         
Gln Asn Val Tyr Gly Ile Thr Ile Ile Ser Gly Leu Pro Pro Glu Lys
        115                 120                 125             
Pro Lys Asn Leu Ser Cys Ile Val Asn Glu Gly Lys Lys Met Arg Cys
    130                 135                 140                 
Glu Trp Asp Gly Gly Arg Glu Thr His Leu Glu Thr Asn Phe Thr Leu
145                 150                 155                 160 
Lys Ser Glu Trp Ala Thr His Lys Phe Ala Asp Cys Lys Ala Lys Arg
                165                 170                 175     
Asp Thr Pro Thr Ser Cys Thr Val Asp Tyr Ser Thr Val Tyr Phe Val
            180                 185                 190         
Asn Ile Glu Val Trp Val Glu Ala Glu Asn Ala Leu Gly Lys Val Thr
        195                 200                 205             
Ser Asp His Ile Asn Phe Asp Pro Val Tyr Lys Val Lys Pro Asn Pro
    210                 215                 220                 
Pro His Asn Leu Ser Val Ile Asn Ser Glu Glu Leu Ser Ser Ile Leu
225                 230                 235                 240 
Lys Leu Thr Trp Thr Asn Pro Ser Ile Lys Ser Val Ile Ile Leu Lys
                245                 250                 255     
Tyr Asn Ile Gln Tyr Arg Thr Lys Asp Ala Ser Thr Trp Ser Gln Ile
            260                 265                 270         
Pro Pro Glu Asp Thr Ala Ser Thr Arg Ser Ser Phe Thr Val Gln Asp
        275                 280                 285             
Leu Lys Pro Phe Thr Glu Tyr Val Phe Arg Ile Arg Cys Met Lys Glu
    290                 295                 300                 
Asp Gly Lys Gly Tyr Trp Ser Asp Trp Ser Glu Glu Ala Ser Gly Ile
305                 310                 315                 320 
Thr Tyr Glu Asp Arg Pro Ser Lys Ala Pro Ser Phe Trp Tyr Lys Ile
                325                 330                 335     
Asp Pro Ser His Thr Gln Gly Tyr Arg Thr Val Gln Leu Val Trp Lys
            340                 345                 350         
Thr Leu Pro Pro Phe Glu Ala Asn Gly Lys Ile Leu Asp Tyr Glu Val
        355                 360                 365             
Thr Leu Thr Arg Trp Lys Ser His Leu Gln Asn Tyr Thr Val Asn Ala
    370                 375                 380                 
Thr Lys Leu Thr Val Asn Leu Thr Asn Asp Arg Tyr Leu Ala Thr Leu
385                 390                 395                 400 
Thr Val Arg Asn Leu Val Gly Lys Ser Asp Ala Ala Val Leu Thr Ile
                405                 410                 415     
Pro Ala Cys Asp Phe Gln Ala Thr His Pro Val Met Asp Leu Lys Ala
            420                 425                 430         
Phe Pro Lys Asp Asn Met Leu Trp Val Glu Trp Thr Thr Pro Arg Glu
        435                 440                 445             
Ser Val Lys Lys Tyr Ile Leu Glu Trp Cys Val Leu Ser Asp Lys Ala
    450                 455                 460                 
Pro Cys Ile Thr Asp Trp Gln Gln Glu Asp Gly Thr Val His Arg Thr
465                 470                 475                 480 
Tyr Leu Arg Gly Asn Leu Ala Glu Ser Lys Cys Tyr Leu Ile Thr Val
                485                 490                 495     
Thr Pro Val Tyr Ala Asp Gly Pro Gly Ser Pro Glu Ser Ile Lys Ala
            500                 505                 510         
Tyr Leu Lys Gln Ala Pro Pro Ser Lys Gly Pro Thr Val Arg Thr Lys
        515                 520                 525             
Lys Val Gly Lys Asn Glu Ala Val Leu Glu Trp Asp Gln Leu Pro Val
    530                 535                 540                 
Asp Val Gln Asn Gly Phe Ile Arg Asn Tyr Thr Ile Phe Tyr Arg Thr
545                 550                 555                 560 
Ile Ile Gly Asn Glu Thr Ala Val Asn Val Asp Ser Ser His Thr Glu
                565                 570                 575     
Tyr Thr Leu Ser Ser Leu Thr Ser Asp Thr Leu Tyr Met Val Arg Met
            580                 585                 590         
Ala Ala Tyr Thr Asp Glu Gly Gly Lys Asp Gly Pro Glu Phe Thr Phe
        595                 600                 605             
Thr Thr Pro Lys Phe Ala Gln Gly Glu Ile Glu Ala Ile Val Val Pro
    610                 615                 620                 
Val Cys Leu Ala Phe Leu Leu Thr Thr Leu Leu Gly Val Leu Phe Cys
625                 630                 635                 640 
Phe Asn Lys Arg Asp Leu Ile Lys Lys His Ile Trp Pro Asn Val Pro
                645                 650                 655     
Asp Pro Ser Lys Ser His Ile Ala Gln Trp Ser Pro His Thr Pro Pro
            660                 665                 670         
Arg His Asn Phe Asn Ser Lys Asp Gln Met Tyr Ser Asp Gly Asn Phe
        675                 680                 685             
Thr Asp Val Ser Val Val Glu Ile Glu Ala Asn Asp Lys Lys Pro Phe
    690                 695                 700                 
Pro Glu Asp Leu Lys Ser Leu Asp Leu Phe Lys Lys Glu Lys Ile Asn
705                 710                 715                 720 
Thr Glu Gly His Ser Ser Gly Ile Gly Gly Ser Ser Cys Met Ser Ser
                725                 730                 735     
Ser Arg Pro Ser Ile Ser Ser Ser Asp Glu Asn Glu Ser Ser Gln Asn
            740                 745                 750         
Thr Ser Ser Thr Val Gln Tyr Ser Thr Val Val His Ser Gly Tyr Arg
        755                 760                 765             
His Gln Val Pro Ser Val Gln Val Phe Ser Arg Ser Glu Ser Thr Gln
    770                 775                 780                 
Pro Leu Leu Asp Ser Glu Glu Arg Pro Glu Asp Leu Gln Leu Val Asp
785                 790                 795                 800 
His Val Asp Gly Gly Asp Gly Ile Leu Pro Arg Gln Gln Tyr Phe Lys
                805                 810                 815     
Gln Asn Cys Ser Gln His Glu Ser Ser Pro Asp Ile Ser His Phe Glu
            820                 825                 830         
Arg Ser Lys Gln Val Ser Ser Val Asn Glu Glu Asp Phe Val Arg Leu
        835                 840                 845             
Lys Gln Gln Ile Ser Asp His Ile Ser Gln Ser Cys Gly Ser Gly Gln
    850                 855                 860                 
Met Lys Met Phe Gln Glu Val Ser Ala Ala Asp Ala Phe Gly Pro Gly
865                 870                 875                 880 
Thr Glu Gly Gln Val Glu Arg Phe Glu Thr Val Gly Met Glu Ala Ala
                885                 890                 895     
Thr Asp Glu Gly Met Pro Lys Ser Tyr Leu Pro Gln Thr Val Arg Gln
            900                 905                 910         
Gly Gly Tyr Met Pro Gln
        915             


<210> 4
<211> 4040
<212> DNA
<213> Homo Sapiens

<220> 
<221> misc_feature   
<222> (0)...(0)
<223> cDNA for IL12RB2 (GenBank Acc No. M57230.1)

<220> 
<221> CDS            
<222> (641)...(3229)

<400> 4
tgcagagcac agagaaagga catctgcgag gaaagttccc tgatggctgt caacaaagtg 60
ccacgtctct atggctgtga acgctgagca cacgatttta tcgcgcctat catatcttgg 120
tgcataaacg cacctcacct cggtcaaccc ttgctccgtc ttatgagaca ggctttatta 180
tccgcatttt atatgagggg aaactgacgg tggagagaga attatcttgc tcaaggcgac 240
acagcagagc ccacaggtgg cagaatccca cccgagcccg cttcgacccg cggggtggaa 300
accacgggcg cccgcccggc tgcgcttcca gagctgaact gagaagcgag tcctctccgc 360
cctgcggcca ccgcccagcc ccgacccccg ccccggcccg atcctcactc gccgccagct 420
ccccgcgccc accccggagt tggtggcgca gaggcgggag gcggaggcgg gagggcgggc 480
gctggcaccg ggaacgcccg agcgccggca gagagcgcgg agagcgcgac acgtgcggcc 540
cagagcaccg gggccacccg gtccccgcag gcccgggacc gcgcccgctg gcaggcgaca 600
cgtggaagaa tacggagttc tataccagag ttgattgttg atg gca cat act ttt   655
                                             Met Ala His Thr Phe
                                              1               5
 
aga gga tgc tca ttg gca ttt atg ttt ata atc acg tgg ctg ttg att   703
Arg Gly Cys Ser Leu Ala Phe Met Phe Ile Ile Thr Trp Leu Leu Ile
                 10                  15                  20
 
aaa gca aaa ata gat gcg tgc aag aga ggc gat gtg act gtg aag cct   751
Lys Ala Lys Ile Asp Ala Cys Lys Arg Gly Asp Val Thr Val Lys Pro
             25                  30                  35
 
tcc cat gta att tta ctt gga tcc act gtc aat att aca tgc tct ttg   799
Ser His Val Ile Leu Leu Gly Ser Thr Val Asn Ile Thr Cys Ser Leu
         40                  45                  50
 
aag ccc aga caa ggc tgc ttt cac tat tcc aga cgt aac aag tta atc   847
Lys Pro Arg Gln Gly Cys Phe His Tyr Ser Arg Arg Asn Lys Leu Ile
     55                  60                  65
 
ctg tac aag ttt gac aga aga atc aat ttt cac cat ggc cac tcc ctc   895
Leu Tyr Lys Phe Asp Arg Arg Ile Asn Phe His His Gly His Ser Leu
 70                  75                  80                  85
 
aat tct caa gtc aca ggt ctt ccc ctt ggt aca acc ttg ttt gtc tgc   943
Asn Ser Gln Val Thr Gly Leu Pro Leu Gly Thr Thr Leu Phe Val Cys
                 90                  95                 100
 
aaa ctg gcc tgt atc aat agt gat gaa att caa ata tgt gga gca gag   991
Lys Leu Ala Cys Ile Asn Ser Asp Glu Ile Gln Ile Cys Gly Ala Glu
            105                 110                 115
 
atc ttc gtt ggt gtt gct cca gaa cag cct caa aat tta tcc tgc ata   1039
Ile Phe Val Gly Val Ala Pro Glu Gln Pro Gln Asn Leu Ser Cys Ile
        120                 125                 130
 
cag aag gga gaa cag ggg act gtg gcc tgc acc tgg gaa aga gga cga   1087
Gln Lys Gly Glu Gln Gly Thr Val Ala Cys Thr Trp Glu Arg Gly Arg
    135                 140                 145
 
gac acc cac tta tac act gag tat act cta cag cta agt gga cca aaa   1135
Asp Thr His Leu Tyr Thr Glu Tyr Thr Leu Gln Leu Ser Gly Pro Lys
150                 155                 160                 165
 
aat tta acc tgg cag aag caa tgt aaa gac att tat tgt gac tat ttg   1183
Asn Leu Thr Trp Gln Lys Gln Cys Lys Asp Ile Tyr Cys Asp Tyr Leu
                170                 175                 180
 
gac ttt gga atc aac ctc acc cct gaa tca cct gaa tcc aat ttc aca   1231
Asp Phe Gly Ile Asn Leu Thr Pro Glu Ser Pro Glu Ser Asn Phe Thr
            185                 190                 195
 
gcc aag gtt act gct gtc aat agt ctt gga agc tcc tct tca ctt cca   1279
Ala Lys Val Thr Ala Val Asn Ser Leu Gly Ser Ser Ser Ser Leu Pro
        200                 205                 210
 
tcc aca ttc aca ttc ttg gac ata gtg agg cct ctt cct ccg tgg gac   1327
Ser Thr Phe Thr Phe Leu Asp Ile Val Arg Pro Leu Pro Pro Trp Asp
    215                 220                 225
 
att aga atc aaa ttt caa aag gct tct gtg agc aga tgt acc ctt tat   1375
Ile Arg Ile Lys Phe Gln Lys Ala Ser Val Ser Arg Cys Thr Leu Tyr
230                 235                 240                 245
 
tgg aga gat gag gga ctg gta ctg ctt aat cga ctc aga tat cgg ccc   1423
Trp Arg Asp Glu Gly Leu Val Leu Leu Asn Arg Leu Arg Tyr Arg Pro
                250                 255                 260
 
agt aac agc agg ctc tgg aat atg gtt aat gtt aca aag gcc aaa gga   1471
Ser Asn Ser Arg Leu Trp Asn Met Val Asn Val Thr Lys Ala Lys Gly
            265                 270                 275
 
aga cat gat ttg ctg gat ctg aaa cca ttt aca gaa tat gaa ttt cag   1519
Arg His Asp Leu Leu Asp Leu Lys Pro Phe Thr Glu Tyr Glu Phe Gln
        280                 285                 290
 
att tcc tct aag cta cat ctt tat aag gga agt tgg agt gat tgg agt   1567
Ile Ser Ser Lys Leu His Leu Tyr Lys Gly Ser Trp Ser Asp Trp Ser
    295                 300                 305
 
gaa tca ttg aga gca caa aca cca gaa gaa gag cct act ggg atg tta   1615
Glu Ser Leu Arg Ala Gln Thr Pro Glu Glu Glu Pro Thr Gly Met Leu
310                 315                 320                 325
 
gat gtc tgg tac atg aaa cgg cac att gac tac agt aga caa cag att   1663
Asp Val Trp Tyr Met Lys Arg His Ile Asp Tyr Ser Arg Gln Gln Ile
                330                 335                 340
 
tct ctt ttc tgg aag aat ctg agt gtc tca gag gca aga gga aaa att   1711
Ser Leu Phe Trp Lys Asn Leu Ser Val Ser Glu Ala Arg Gly Lys Ile
            345                 350                 355
 
ctc cac tat cag gtg acc ttg cag gag ctg aca gga ggg aaa gcc atg   1759
Leu His Tyr Gln Val Thr Leu Gln Glu Leu Thr Gly Gly Lys Ala Met
        360                 365                 370
 
aca cag aac atc aca gga cac acc tcc tgg acc aca gtc att cct aga   1807
Thr Gln Asn Ile Thr Gly His Thr Ser Trp Thr Thr Val Ile Pro Arg
    375                 380                 385
 
acc gga aat tgg gct gtg gct gtg tct gca gca aat tca aaa ggc agt   1855
Thr Gly Asn Trp Ala Val Ala Val Ser Ala Ala Asn Ser Lys Gly Ser
390                 395                 400                 405
 
tct ctg ccc act cgt att aac ata atg aac ctg tgt gag gca ggg ttg   1903
Ser Leu Pro Thr Arg Ile Asn Ile Met Asn Leu Cys Glu Ala Gly Leu
                410                 415                 420
 
ctg gct cct cgc cag gtc tct gca aac tca gag ggc atg gac aac att   1951
Leu Ala Pro Arg Gln Val Ser Ala Asn Ser Glu Gly Met Asp Asn Ile
            425                 430                 435
 
ctg gtg act tgg cag cct ccc agg aaa gat ccc tct gct gtt cag gag   1999
Leu Val Thr Trp Gln Pro Pro Arg Lys Asp Pro Ser Ala Val Gln Glu
        440                 445                 450
 
tac gtg gtg gaa tgg aga gag ctc cat cca ggg ggt gac aca cag gtc   2047
Tyr Val Val Glu Trp Arg Glu Leu His Pro Gly Gly Asp Thr Gln Val
    455                 460                 465
 
cct cta aac tgg cta cgg agt cga ccc tac aat gtg tct gct ctg att   2095
Pro Leu Asn Trp Leu Arg Ser Arg Pro Tyr Asn Val Ser Ala Leu Ile
470                 475                 480                 485
 
tca gag aac ata aaa tcc tac atc tgt tat gaa atc cgt gtg tat gca   2143
Ser Glu Asn Ile Lys Ser Tyr Ile Cys Tyr Glu Ile Arg Val Tyr Ala
                490                 495                 500
 
ctc tca ggg gat caa gga gga tgc agc tcc atc ctg ggt aac tct aag   2191
Leu Ser Gly Asp Gln Gly Gly Cys Ser Ser Ile Leu Gly Asn Ser Lys
            505                 510                 515
 
cac aaa gca cca ctg agt ggc ccc cac att aat gcc atc aca gag gaa   2239
His Lys Ala Pro Leu Ser Gly Pro His Ile Asn Ala Ile Thr Glu Glu
        520                 525                 530
 
aag ggg agc att tta att tca tgg aac agc att cca gtc cag gag caa   2287
Lys Gly Ser Ile Leu Ile Ser Trp Asn Ser Ile Pro Val Gln Glu Gln
    535                 540                 545
 
atg ggc tgc ctc ctc cat tat agg ata tac tgg aag gaa cgg gac tcc   2335
Met Gly Cys Leu Leu His Tyr Arg Ile Tyr Trp Lys Glu Arg Asp Ser
550                 555                 560                 565
 
aac tcc cag cct cag ctc tgt gaa att ccc tac aga gtc tcc caa aat   2383
Asn Ser Gln Pro Gln Leu Cys Glu Ile Pro Tyr Arg Val Ser Gln Asn
                570                 575                 580
 
tca cat cca ata aac agc ctg cag ccc cga gtg aca tat gtc ctg tgg   2431
Ser His Pro Ile Asn Ser Leu Gln Pro Arg Val Thr Tyr Val Leu Trp
            585                 590                 595
 
atg aca gct ctg aca gct gct ggt gaa agt tcc cac gga aat gag agg   2479
Met Thr Ala Leu Thr Ala Ala Gly Glu Ser Ser His Gly Asn Glu Arg
        600                 605                 610
 
gaa ttt tgt ctg caa ggt aaa gcc aat tgg atg gcg ttt gtg gca cca   2527
Glu Phe Cys Leu Gln Gly Lys Ala Asn Trp Met Ala Phe Val Ala Pro
    615                 620                 625
 
agc att tgc att gct atc atc atg gtg ggc att ttc tca acg cat tac   2575
Ser Ile Cys Ile Ala Ile Ile Met Val Gly Ile Phe Ser Thr His Tyr
630                 635                 640                 645
 
ttc cag caa aag gtg ttt gtt ctc cta gca gcc ctc aga cct cag tgg   2623
Phe Gln Gln Lys Val Phe Val Leu Leu Ala Ala Leu Arg Pro Gln Trp
                650                 655                 660
 
tgt agc aga gaa att cca gat cca gca aat agc act tgc gct aag aaa   2671
Cys Ser Arg Glu Ile Pro Asp Pro Ala Asn Ser Thr Cys Ala Lys Lys
            665                 670                 675
 
tat ccc att gca gag gag aag aca cag ctg ccc ttg gac agg ctc ctg   2719
Tyr Pro Ile Ala Glu Glu Lys Thr Gln Leu Pro Leu Asp Arg Leu Leu
        680                 685                 690
 
ata gac tgg ccc acg cct gaa gat cct gaa ccg ctg gtc atc agt gaa   2767
Ile Asp Trp Pro Thr Pro Glu Asp Pro Glu Pro Leu Val Ile Ser Glu
    695                 700                 705
 
gtc ctt cat caa gtg acc cca gtt ttc aga cat ccc ccc tgc tcc aac   2815
Val Leu His Gln Val Thr Pro Val Phe Arg His Pro Pro Cys Ser Asn
710                 715                 720                 725
 
tgg cca caa agg gaa aaa gga atc caa ggt cat cag gcc tct gag aaa   2863
Trp Pro Gln Arg Glu Lys Gly Ile Gln Gly His Gln Ala Ser Glu Lys
                730                 735                 740
 
gac atg atg cac agt gcc tca agc cca cca cct cca aga gct ctc caa   2911
Asp Met Met His Ser Ala Ser Ser Pro Pro Pro Pro Arg Ala Leu Gln
            745                 750                 755
 
gct gag agc aga caa ctg gtg gat ctg tac aag gtg ctg gag agc agg   2959
Ala Glu Ser Arg Gln Leu Val Asp Leu Tyr Lys Val Leu Glu Ser Arg
        760                 765                 770
 
ggc tcc gac cca aag ccc gaa aac cca gcc tgt ccc tgg acg gtg ctc   3007
Gly Ser Asp Pro Lys Pro Glu Asn Pro Ala Cys Pro Trp Thr Val Leu
    775                 780                 785
 
cca gca ggt gac ctt ccc acc cat gat ggc tac tta ccc tcc aac ata   3055
Pro Ala Gly Asp Leu Pro Thr His Asp Gly Tyr Leu Pro Ser Asn Ile
790                 795                 800                 805
 
gat gac ctc ccc tca cat gag gca cct ctc gct gac tct ctg gaa gaa   3103
Asp Asp Leu Pro Ser His Glu Ala Pro Leu Ala Asp Ser Leu Glu Glu
                810                 815                 820
 
ctg gag cct cag cac atc tcc ctt tct gtt ttc ccc tca agt tct ctt   3151
Leu Glu Pro Gln His Ile Ser Leu Ser Val Phe Pro Ser Ser Ser Leu
            825                 830                 835
 
cac cca ctc acc ttc tcc tgt ggt gat aag ctg act ctg gat cag tta   3199
His Pro Leu Thr Phe Ser Cys Gly Asp Lys Leu Thr Leu Asp Gln Leu
        840                 845                 850
 
aag atg agg tgt gac tcc ctc atg ctc tga gtggtgaggc ttcaagcctt     3249
Lys Met Arg Cys Asp Ser Leu Met Leu  *
    855                 860
 
aaagtcagtg tgccctcaac cagcacagcc tgccccaatt cccccagccc ctgctccagc 3309
agctgtcatc tctgggtgcc accatcggtc tggctgcagc tagaggacag gcaagccagc 3369
tctgggggag tcttaggaac tgggagttgg tcttcactca gatgcctcat cttgcctttc 3429
ccagggcctt aaaattacat ccttcactgt gtggacctag agactccaac ttgaattcct 3489
agtaactttc ttggtatgct ggccagaaag ggaaatgagg aggagagtag aaaccacagc 3549
tcttagtagt aatggcatac agtctagagg accattcatg caatgactat ttctaaagca 3609
cctgctacac agcaggctgt acacagcaga tcagtactgt tcaacagaac ttcctgagat 3669
gatggaaatg ttctacctct gcactcactg tccagtacat tagacactag gcacattggc 3729
tgttaatcac ttggaatgtg tttagcttga ctgaggaatt aaattttgat tgtaaattta 3789
aatcgccaca catggctagt ggctactgta ttggagtgca cagctctaga tggctcctag 3849
attattgaga gccttcaaaa caaatcaacc tagttctata gatgaagaca taaaagacac 3909
tggtaaacac caaggtaaaa gggcccccaa ggtggtcatg actggtctca tttgcagaag 3969
tctaagaatg tacctttttc tggccgggcg tggtagctca tgcctgtaat cccagcactt 4029
tgggaggctg a                                                      4040

<210> 5
<211> 2589
<212> DNA
<213> Homo Sapiens

<220> 
<221> misc_feature   
<222> (0)...(0)
<223> coding sequence for IL12RB2

<220> 
<221> CDS            
<222> (1)...(2589)

<400> 5
atg gca cat act ttt aga gga tgc tca ttg gca ttt atg ttt ata atc   48
Met Ala His Thr Phe Arg Gly Cys Ser Leu Ala Phe Met Phe Ile Ile
 1               5                   10                  15
 
acg tgg ctg ttg att aaa gca aaa ata gat gcg tgc aag aga ggc gat   96
Thr Trp Leu Leu Ile Lys Ala Lys Ile Asp Ala Cys Lys Arg Gly Asp
             20                  25                  30
 
gtg act gtg aag cct tcc cat gta att tta ctt gga tcc act gtc aat   144
Val Thr Val Lys Pro Ser His Val Ile Leu Leu Gly Ser Thr Val Asn
         35                  40                  45
 
att aca tgc tct ttg aag ccc aga caa ggc tgc ttt cac tat tcc aga   192
Ile Thr Cys Ser Leu Lys Pro Arg Gln Gly Cys Phe His Tyr Ser Arg
     50                  55                  60
 
cgt aac aag tta atc ctg tac aag ttt gac aga aga atc aat ttt cac   240
Arg Asn Lys Leu Ile Leu Tyr Lys Phe Asp Arg Arg Ile Asn Phe His
 65                  70                  75                  80
 
cat ggc cac tcc ctc aat tct caa gtc aca ggt ctt ccc ctt ggt aca   288
His Gly His Ser Leu Asn Ser Gln Val Thr Gly Leu Pro Leu Gly Thr
                 85                  90                  95
 
acc ttg ttt gtc tgc aaa ctg gcc tgt atc aat agt gat gaa att caa   336
Thr Leu Phe Val Cys Lys Leu Ala Cys Ile Asn Ser Asp Glu Ile Gln
            100                 105                 110
 
ata tgt gga gca gag atc ttc gtt ggt gtt gct cca gaa cag cct caa   384
Ile Cys Gly Ala Glu Ile Phe Val Gly Val Ala Pro Glu Gln Pro Gln
        115                 120                 125
 
aat tta tcc tgc ata cag aag gga gaa cag ggg act gtg gcc tgc acc   432
Asn Leu Ser Cys Ile Gln Lys Gly Glu Gln Gly Thr Val Ala Cys Thr
    130                 135                 140
 
tgg gaa aga gga cga gac acc cac tta tac act gag tat act cta cag   480
Trp Glu Arg Gly Arg Asp Thr His Leu Tyr Thr Glu Tyr Thr Leu Gln
145                 150                 155                 160
 
cta agt gga cca aaa aat tta acc tgg cag aag caa tgt aaa gac att   528
Leu Ser Gly Pro Lys Asn Leu Thr Trp Gln Lys Gln Cys Lys Asp Ile
                165                 170                 175
 
tat tgt gac tat ttg gac ttt gga atc aac ctc acc cct gaa tca cct   576
Tyr Cys Asp Tyr Leu Asp Phe Gly Ile Asn Leu Thr Pro Glu Ser Pro
            180                 185                 190
 
gaa tcc aat ttc aca gcc aag gtt act gct gtc aat agt ctt gga agc   624
Glu Ser Asn Phe Thr Ala Lys Val Thr Ala Val Asn Ser Leu Gly Ser
        195                 200                 205
 
tcc tct tca ctt cca tcc aca ttc aca ttc ttg gac ata gtg agg cct   672
Ser Ser Ser Leu Pro Ser Thr Phe Thr Phe Leu Asp Ile Val Arg Pro
    210                 215                 220
 
ctt cct ccg tgg gac att aga atc aaa ttt caa aag gct tct gtg agc   720
Leu Pro Pro Trp Asp Ile Arg Ile Lys Phe Gln Lys Ala Ser Val Ser
225                 230                 235                 240
 
aga tgt acc ctt tat tgg aga gat gag gga ctg gta ctg ctt aat cga   768
Arg Cys Thr Leu Tyr Trp Arg Asp Glu Gly Leu Val Leu Leu Asn Arg
                245                 250                 255
 
ctc aga tat cgg ccc agt aac agc agg ctc tgg aat atg gtt aat gtt   816
Leu Arg Tyr Arg Pro Ser Asn Ser Arg Leu Trp Asn Met Val Asn Val
            260                 265                 270
 
aca aag gcc aaa gga aga cat gat ttg ctg gat ctg aaa cca ttt aca   864
Thr Lys Ala Lys Gly Arg His Asp Leu Leu Asp Leu Lys Pro Phe Thr
        275                 280                 285
 
gaa tat gaa ttt cag att tcc tct aag cta cat ctt tat aag gga agt   912
Glu Tyr Glu Phe Gln Ile Ser Ser Lys Leu His Leu Tyr Lys Gly Ser
    290                 295                 300
 
tgg agt gat tgg agt gaa tca ttg aga gca caa aca cca gaa gaa gag   960
Trp Ser Asp Trp Ser Glu Ser Leu Arg Ala Gln Thr Pro Glu Glu Glu
305                 310                 315                 320
 
cct act ggg atg tta gat gtc tgg tac atg aaa cgg cac att gac tac   1008
Pro Thr Gly Met Leu Asp Val Trp Tyr Met Lys Arg His Ile Asp Tyr
                325                 330                 335
 
agt aga caa cag att tct ctt ttc tgg aag aat ctg agt gtc tca gag   1056
Ser Arg Gln Gln Ile Ser Leu Phe Trp Lys Asn Leu Ser Val Ser Glu
            340                 345                 350
 
gca aga gga aaa att ctc cac tat cag gtg acc ttg cag gag ctg aca   1104
Ala Arg Gly Lys Ile Leu His Tyr Gln Val Thr Leu Gln Glu Leu Thr
        355                 360                 365
 
gga ggg aaa gcc atg aca cag aac atc aca gga cac acc tcc tgg acc   1152
Gly Gly Lys Ala Met Thr Gln Asn Ile Thr Gly His Thr Ser Trp Thr
    370                 375                 380
 
aca gtc att cct aga acc gga aat tgg gct gtg gct gtg tct gca gca   1200
Thr Val Ile Pro Arg Thr Gly Asn Trp Ala Val Ala Val Ser Ala Ala
385                 390                 395                 400
 
aat tca aaa ggc agt tct ctg ccc act cgt att aac ata atg aac ctg   1248
Asn Ser Lys Gly Ser Ser Leu Pro Thr Arg Ile Asn Ile Met Asn Leu
                405                 410                 415
 
tgt gag gca ggg ttg ctg gct cct cgc cag gtc tct gca aac tca gag   1296
Cys Glu Ala Gly Leu Leu Ala Pro Arg Gln Val Ser Ala Asn Ser Glu
            420                 425                 430
 
ggc atg gac aac att ctg gtg act tgg cag cct ccc agg aaa gat ccc   1344
Gly Met Asp Asn Ile Leu Val Thr Trp Gln Pro Pro Arg Lys Asp Pro
        435                 440                 445
 
tct gct gtt cag gag tac gtg gtg gaa tgg aga gag ctc cat cca ggg   1392
Ser Ala Val Gln Glu Tyr Val Val Glu Trp Arg Glu Leu His Pro Gly
    450                 455                 460
 
ggt gac aca cag gtc cct cta aac tgg cta cgg agt cga ccc tac aat   1440
Gly Asp Thr Gln Val Pro Leu Asn Trp Leu Arg Ser Arg Pro Tyr Asn
465                 470                 475                 480
 
gtg tct gct ctg att tca gag aac ata aaa tcc tac atc tgt tat gaa   1488
Val Ser Ala Leu Ile Ser Glu Asn Ile Lys Ser Tyr Ile Cys Tyr Glu
                485                 490                 495
 
atc cgt gtg tat gca ctc tca ggg gat caa gga gga tgc agc tcc atc   1536
Ile Arg Val Tyr Ala Leu Ser Gly Asp Gln Gly Gly Cys Ser Ser Ile
            500                 505                 510
 
ctg ggt aac tct aag cac aaa gca cca ctg agt ggc ccc cac att aat   1584
Leu Gly Asn Ser Lys His Lys Ala Pro Leu Ser Gly Pro His Ile Asn
        515                 520                 525
 
gcc atc aca gag gaa aag ggg agc att tta att tca tgg aac agc att   1632
Ala Ile Thr Glu Glu Lys Gly Ser Ile Leu Ile Ser Trp Asn Ser Ile
    530                 535                 540
 
cca gtc cag gag caa atg ggc tgc ctc ctc cat tat agg ata tac tgg   1680
Pro Val Gln Glu Gln Met Gly Cys Leu Leu His Tyr Arg Ile Tyr Trp
545                 550                 555                 560
 
aag gaa cgg gac tcc aac tcc cag cct cag ctc tgt gaa att ccc tac   1728
Lys Glu Arg Asp Ser Asn Ser Gln Pro Gln Leu Cys Glu Ile Pro Tyr
                565                 570                 575
 
aga gtc tcc caa aat tca cat cca ata aac agc ctg cag ccc cga gtg   1776
Arg Val Ser Gln Asn Ser His Pro Ile Asn Ser Leu Gln Pro Arg Val
            580                 585                 590
 
aca tat gtc ctg tgg atg aca gct ctg aca gct gct ggt gaa agt tcc   1824
Thr Tyr Val Leu Trp Met Thr Ala Leu Thr Ala Ala Gly Glu Ser Ser
        595                 600                 605
 
cac gga aat gag agg gaa ttt tgt ctg caa ggt aaa gcc aat tgg atg   1872
His Gly Asn Glu Arg Glu Phe Cys Leu Gln Gly Lys Ala Asn Trp Met
    610                 615                 620
 
gcg ttt gtg gca cca agc att tgc att gct atc atc atg gtg ggc att   1920
Ala Phe Val Ala Pro Ser Ile Cys Ile Ala Ile Ile Met Val Gly Ile
625                 630                 635                 640
 
ttc tca acg cat tac ttc cag caa aag gtg ttt gtt ctc cta gca gcc   1968
Phe Ser Thr His Tyr Phe Gln Gln Lys Val Phe Val Leu Leu Ala Ala
                645                 650                 655
 
ctc aga cct cag tgg tgt agc aga gaa att cca gat cca gca aat agc   2016
Leu Arg Pro Gln Trp Cys Ser Arg Glu Ile Pro Asp Pro Ala Asn Ser
            660                 665                 670
 
act tgc gct aag aaa tat ccc att gca gag gag aag aca cag ctg ccc   2064
Thr Cys Ala Lys Lys Tyr Pro Ile Ala Glu Glu Lys Thr Gln Leu Pro
        675                 680                 685
 
ttg gac agg ctc ctg ata gac tgg ccc acg cct gaa gat cct gaa ccg   2112
Leu Asp Arg Leu Leu Ile Asp Trp Pro Thr Pro Glu Asp Pro Glu Pro
    690                 695                 700
 
ctg gtc atc agt gaa gtc ctt cat caa gtg acc cca gtt ttc aga cat   2160
Leu Val Ile Ser Glu Val Leu His Gln Val Thr Pro Val Phe Arg His
705                 710                 715                 720
 
ccc ccc tgc tcc aac tgg cca caa agg gaa aaa gga atc caa ggt cat   2208
Pro Pro Cys Ser Asn Trp Pro Gln Arg Glu Lys Gly Ile Gln Gly His
                725                 730                 735
 
cag gcc tct gag aaa gac atg atg cac agt gcc tca agc cca cca cct   2256
Gln Ala Ser Glu Lys Asp Met Met His Ser Ala Ser Ser Pro Pro Pro
            740                 745                 750
 
cca aga gct ctc caa gct gag agc aga caa ctg gtg gat ctg tac aag   2304
Pro Arg Ala Leu Gln Ala Glu Ser Arg Gln Leu Val Asp Leu Tyr Lys
        755                 760                 765
 
gtg ctg gag agc agg ggc tcc gac cca aag ccc gaa aac cca gcc tgt   2352
Val Leu Glu Ser Arg Gly Ser Asp Pro Lys Pro Glu Asn Pro Ala Cys
    770                 775                 780
 
ccc tgg acg gtg ctc cca gca ggt gac ctt ccc acc cat gat ggc tac   2400
Pro Trp Thr Val Leu Pro Ala Gly Asp Leu Pro Thr His Asp Gly Tyr
785                 790                 795                 800
 
tta ccc tcc aac ata gat gac ctc ccc tca cat gag gca cct ctc gct   2448
Leu Pro Ser Asn Ile Asp Asp Leu Pro Ser His Glu Ala Pro Leu Ala
                805                 810                 815
 
gac tct ctg gaa gaa ctg gag cct cag cac atc tcc ctt tct gtt ttc   2496
Asp Ser Leu Glu Glu Leu Glu Pro Gln His Ile Ser Leu Ser Val Phe
            820                 825                 830
 
ccc tca agt tct ctt cac cca ctc acc ttc tcc tgt ggt gat aag ctg   2544
Pro Ser Ser Ser Leu His Pro Leu Thr Phe Ser Cys Gly Asp Lys Leu
        835                 840                 845
 
act ctg gat cag tta aag atg agg tgt gac tcc ctc atg ctc tga       2589
Thr Leu Asp Gln Leu Lys Met Arg Cys Asp Ser Leu Met Leu  *
    850                 855                 860
 


<210> 6
<211> 862
<212> PRT
<213> Homo sapiens

<400> 6
Met Ala His Thr Phe Arg Gly Cys Ser Leu Ala Phe Met Phe Ile Ile
 1               5                  10                  15      
Thr Trp Leu Leu Ile Lys Ala Lys Ile Asp Ala Cys Lys Arg Gly Asp
            20                  25                  30          
Val Thr Val Lys Pro Ser His Val Ile Leu Leu Gly Ser Thr Val Asn
        35                  40                  45              
Ile Thr Cys Ser Leu Lys Pro Arg Gln Gly Cys Phe His Tyr Ser Arg
    50                  55                  60                  
Arg Asn Lys Leu Ile Leu Tyr Lys Phe Asp Arg Arg Ile Asn Phe His
65                  70                  75                  80  
His Gly His Ser Leu Asn Ser Gln Val Thr Gly Leu Pro Leu Gly Thr
                85                  90                  95      
Thr Leu Phe Val Cys Lys Leu Ala Cys Ile Asn Ser Asp Glu Ile Gln
            100                 105                 110         
Ile Cys Gly Ala Glu Ile Phe Val Gly Val Ala Pro Glu Gln Pro Gln
        115                 120                 125             
Asn Leu Ser Cys Ile Gln Lys Gly Glu Gln Gly Thr Val Ala Cys Thr
    130                 135                 140                 
Trp Glu Arg Gly Arg Asp Thr His Leu Tyr Thr Glu Tyr Thr Leu Gln
145                 150                 155                 160 
Leu Ser Gly Pro Lys Asn Leu Thr Trp Gln Lys Gln Cys Lys Asp Ile
                165                 170                 175     
Tyr Cys Asp Tyr Leu Asp Phe Gly Ile Asn Leu Thr Pro Glu Ser Pro
            180                 185                 190         
Glu Ser Asn Phe Thr Ala Lys Val Thr Ala Val Asn Ser Leu Gly Ser
        195                 200                 205             
Ser Ser Ser Leu Pro Ser Thr Phe Thr Phe Leu Asp Ile Val Arg Pro
    210                 215                 220                 
Leu Pro Pro Trp Asp Ile Arg Ile Lys Phe Gln Lys Ala Ser Val Ser
225                 230                 235                 240 
Arg Cys Thr Leu Tyr Trp Arg Asp Glu Gly Leu Val Leu Leu Asn Arg
                245                 250                 255     
Leu Arg Tyr Arg Pro Ser Asn Ser Arg Leu Trp Asn Met Val Asn Val
            260                 265                 270         
Thr Lys Ala Lys Gly Arg His Asp Leu Leu Asp Leu Lys Pro Phe Thr
        275                 280                 285             
Glu Tyr Glu Phe Gln Ile Ser Ser Lys Leu His Leu Tyr Lys Gly Ser
    290                 295                 300                 
Trp Ser Asp Trp Ser Glu Ser Leu Arg Ala Gln Thr Pro Glu Glu Glu
305                 310                 315                 320 
Pro Thr Gly Met Leu Asp Val Trp Tyr Met Lys Arg His Ile Asp Tyr
                325                 330                 335     
Ser Arg Gln Gln Ile Ser Leu Phe Trp Lys Asn Leu Ser Val Ser Glu
            340                 345                 350         
Ala Arg Gly Lys Ile Leu His Tyr Gln Val Thr Leu Gln Glu Leu Thr
        355                 360                 365             
Gly Gly Lys Ala Met Thr Gln Asn Ile Thr Gly His Thr Ser Trp Thr
    370                 375                 380                 
Thr Val Ile Pro Arg Thr Gly Asn Trp Ala Val Ala Val Ser Ala Ala
385                 390                 395                 400 
Asn Ser Lys Gly Ser Ser Leu Pro Thr Arg Ile Asn Ile Met Asn Leu
                405                 410                 415     
Cys Glu Ala Gly Leu Leu Ala Pro Arg Gln Val Ser Ala Asn Ser Glu
            420                 425                 430         
Gly Met Asp Asn Ile Leu Val Thr Trp Gln Pro Pro Arg Lys Asp Pro
        435                 440                 445             
Ser Ala Val Gln Glu Tyr Val Val Glu Trp Arg Glu Leu His Pro Gly
    450                 455                 460                 
Gly Asp Thr Gln Val Pro Leu Asn Trp Leu Arg Ser Arg Pro Tyr Asn
465                 470                 475                 480 
Val Ser Ala Leu Ile Ser Glu Asn Ile Lys Ser Tyr Ile Cys Tyr Glu
                485                 490                 495     
Ile Arg Val Tyr Ala Leu Ser Gly Asp Gln Gly Gly Cys Ser Ser Ile
            500                 505                 510         
Leu Gly Asn Ser Lys His Lys Ala Pro Leu Ser Gly Pro His Ile Asn
        515                 520                 525             
Ala Ile Thr Glu Glu Lys Gly Ser Ile Leu Ile Ser Trp Asn Ser Ile
    530                 535                 540                 
Pro Val Gln Glu Gln Met Gly Cys Leu Leu His Tyr Arg Ile Tyr Trp
545                 550                 555                 560 
Lys Glu Arg Asp Ser Asn Ser Gln Pro Gln Leu Cys Glu Ile Pro Tyr
                565                 570                 575     
Arg Val Ser Gln Asn Ser His Pro Ile Asn Ser Leu Gln Pro Arg Val
            580                 585                 590         
Thr Tyr Val Leu Trp Met Thr Ala Leu Thr Ala Ala Gly Glu Ser Ser
        595                 600                 605             
His Gly Asn Glu Arg Glu Phe Cys Leu Gln Gly Lys Ala Asn Trp Met
    610                 615                 620                 
Ala Phe Val Ala Pro Ser Ile Cys Ile Ala Ile Ile Met Val Gly Ile
625                 630                 635                 640 
Phe Ser Thr His Tyr Phe Gln Gln Lys Val Phe Val Leu Leu Ala Ala
                645                 650                 655     
Leu Arg Pro Gln Trp Cys Ser Arg Glu Ile Pro Asp Pro Ala Asn Ser
            660                 665                 670         
Thr Cys Ala Lys Lys Tyr Pro Ile Ala Glu Glu Lys Thr Gln Leu Pro
        675                 680                 685             
Leu Asp Arg Leu Leu Ile Asp Trp Pro Thr Pro Glu Asp Pro Glu Pro
    690                 695                 700                 
Leu Val Ile Ser Glu Val Leu His Gln Val Thr Pro Val Phe Arg His
705                 710                 715                 720 
Pro Pro Cys Ser Asn Trp Pro Gln Arg Glu Lys Gly Ile Gln Gly His
                725                 730                 735     
Gln Ala Ser Glu Lys Asp Met Met His Ser Ala Ser Ser Pro Pro Pro
            740                 745                 750         
Pro Arg Ala Leu Gln Ala Glu Ser Arg Gln Leu Val Asp Leu Tyr Lys
        755                 760                 765             
Val Leu Glu Ser Arg Gly Ser Asp Pro Lys Pro Glu Asn Pro Ala Cys
    770                 775                 780                 
Pro Trp Thr Val Leu Pro Ala Gly Asp Leu Pro Thr His Asp Gly Tyr
785                 790                 795                 800 
Leu Pro Ser Asn Ile Asp Asp Leu Pro Ser His Glu Ala Pro Leu Ala
                805                 810                 815     
Asp Ser Leu Glu Glu Leu Glu Pro Gln His Ile Ser Leu Ser Val Phe
            820                 825                 830         
Pro Ser Ser Ser Leu His Pro Leu Thr Phe Ser Cys Gly Asp Lys Leu
        835                 840                 845             
Thr Leu Asp Gln Leu Lys Met Arg Cys Asp Ser Leu Met Leu
    850                 855                 860         




1
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LEGAL02/32279965v1

LEGAL02/32279965v1

