                         SEQUENCE LISTING

<110>  Sanford, Isaac
       Hodges, Jonathan
       Nair, Shrikumar
       Darby, Martyn
       Chen, Yuchen
       Hamilton, Paul
       Jansen, Michelle
       Gron, Hanne
       Sathya, Ganesan
 
<120>  METHODS AND COMPOSITIONS FOR SOFT TISSUE REPAIR

<130>  AF-040-US1

<160>  43    

<170>  PatentIn version 3.4

<210>  1
<211>  21
<212>  PRT
<213>  Synthetic

<400>  1

Ser Ser Met Tyr Phe Ser Pro Leu His Thr Trp Gln Ser Ala Pro Ser 
1               5                   10                  15      


Thr Ser Gly Ala Glu 
            20      


<210>  2
<211>  21
<212>  PRT
<213>  Synthetic

<400>  2

Ser Ser Phe Arg Phe Gln Arg Leu Glu Asp Trp Asn Tyr Pro Ser Asn 
1               5                   10                  15      


Thr Asp Asn Ala Glu 
            20      


<210>  3
<211>  21
<212>  PRT
<213>  Synthetic

<400>  3

Ser Ser Gly Tyr Met Gln Phe Gly His Leu Leu Asp Trp Thr Gly Ser 
1               5                   10                  15      


Pro Ser Gly Ser Arg 
            20      


<210>  4
<211>  19
<212>  PRT
<213>  Synthetic

<400>  4

Ser Ser Phe Trp Asp Val Cys Gln Gly Asp Gly Thr Cys Tyr Gly Gly 
1               5                   10                  15      


Gly Ser Arg 
            


<210>  5
<211>  15
<212>  PRT
<213>  Synthetic

<400>  5

Val Ala Asn Pro Phe Thr Tyr Leu Ser Ala Trp Ser Asn Pro Leu 
1               5                   10                  15  


<210>  6
<211>  16
<212>  PRT
<213>  Synthetic

<400>  6

Glu Thr Leu Ile Phe Ser Lys Leu Gly Gln Trp Gly Asn Ser Leu Ser 
1               5                   10                  15      


<210>  7
<211>  15
<212>  PRT
<213>  Synthetic

<400>  7

Gly Tyr Met Gln Phe Gly His Leu Leu Asp Trp Thr Gly Ser Pro 
1               5                   10                  15  


<210>  8
<211>  15
<212>  PRT
<213>  Synthetic

<400>  8

Ser Val Tyr Arg Phe Asp Ser Leu Thr Thr Trp Ser Ser Asn Gln 
1               5                   10                  15  


<210>  9
<211>  15
<212>  PRT
<213>  Synthetic

<400>  9

Gly Ser Trp Ser Phe Gly Thr Leu Gly Pro Trp Ser Ser Ser Gln 
1               5                   10                  15  


<210>  10
<211>  15
<212>  PRT
<213>  Synthetic

<400>  10

Trp Leu Gly Asn Phe Asn Ala Leu Thr Asp Trp Pro Thr Asp Ser 
1               5                   10                  15  


<210>  11
<211>  15
<212>  PRT
<213>  Synthetic

<400>  11

Thr Ser Gly Phe Phe Gly Ser Leu Asp Thr Trp Pro Pro Thr Leu 
1               5                   10                  15  


<210>  12
<211>  12
<212>  PRT
<213>  Synthetic

<400>  12

Asn Tyr Trp Asn Phe Gly Pro Leu Glu Asp Tyr Ser 
1               5                   10          


<210>  13
<211>  12
<212>  PRT
<213>  Synthetic

<400>  13

Ser Val Leu His Phe His Pro Met Lys Ser Tyr Asp 
1               5                   10          


<210>  14
<211>  12
<212>  PRT
<213>  Synthetic

<400>  14

Asn Ser Ile Tyr Phe Ser Pro Leu Arg Asp Tyr Gln 
1               5                   10          


<210>  15
<211>  12
<212>  PRT
<213>  Synthetic

<400>  15

Gly His Phe Glu Tyr Gly Arg Leu Gln Ser Ile Leu 
1               5                   10          


<210>  16
<211>  20
<212>  PRT
<213>  Synthetic

<400>  16

Ser Ser Phe Arg Phe Gly Pro Leu Gly Thr Trp Asn Tyr Pro Ser Thr 
1               5                   10                  15      


Asp Asn Ala Glu 
            20  


<210>  17
<211>  14
<212>  PRT
<213>  Synthetic


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  X=F, M, L, Y, W, or N

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  X= R, Q, P, I, Y or S

<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  X= G, S, Q, T, or D

<220>
<221>  MISC_FEATURE
<222>  (5)..(5)
<223>  X= P, R, Y, K, H, or S

<220>
<221>  MISC_FEATURE
<222>  (7)..(7)
<223>  X= G, H, E, S, L, or T

<220>
<221>  MISC_FEATURE
<222>  (8)..(8)
<223>  X= T, D, A, Q, or P

<220>
<221>  MISC_FEATURE
<222>  (10)..(10)
<223>  X= N, Q, S, G, or T

<220>
<221>  MISC_FEATURE
<222>  (11)..(11)
<223>  X= Y, S, N, or G

<220>
<221>  MISC_FEATURE
<222>  (12)..(12)
<223>  X= P, A, S, or N

<220>
<221>  MISC_FEATURE
<222>  (13)..(13)
<223>  X= S, P, L, or Q

<220>
<221>  MISC_FEATURE
<222>  (13)..(13)
<223>  X= T, S, or N

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  Xaa can be any naturally occurring amino acid

<400>  17

Xaa Xaa Phe Xaa Xaa Leu Xaa Xaa Trp Xaa Xaa Xaa Xaa Xaa 
1               5                   10                  


<210>  18
<211>  14
<212>  PRT
<213>  Synthetic


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  X = F, W, L, Y, M, or I

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  X = N, Y, R, P, Q, I, F, or E

<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  X = F or Y

<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  X = G, S, T, Q, N, H, or D

<220>
<221>  MISC_FEATURE
<222>  (5)..(5)
<223>  X = P, R, Y, T, S, K, H, or A

<220>
<221>  MISC_FEATURE
<222>  (6)..(6)
<223>  X = L or M

<220>
<221>  MISC_FEATURE
<222>  (7)..(7)
<223>  X = T, G, E, S, R, Q, L, K, H, or D

<220>
<221>  MISC_FEATURE
<222>  (8)..(8)
<223>  X = D, T, S, Q, P, or A

<220>
<221>  MISC_FEATURE
<222>  (9)..(9)
<223>  X = W, Y, or I

<220>
<221>  MISC_FEATURE
<222>  (10)..(10)
<223>  X = P, N, Q, S, G, L, D, or T

<220>
<221>  MISC_FEATURE
<222>  (11)..(11)
<223>  X = Y, S, N, T, P, or G

<220>
<221>  MISC_FEATURE
<222>  (12)..(12)
<223>  X = P, A, S, T, D, or N

<220>
<221>  MISC_FEATURE
<222>  (13)..(13)
<223>  X = S, P, L, or Q

<220>
<221>  MISC_FEATURE
<222>  (14)..(14)
<223>  X = S or N

<400>  18

Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
1               5                   10                  


<210>  19
<211>  16
<212>  PRT
<213>  Synthetic


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  X = S, N, T, I, V, or G

<220>
<221>  MISC_FEATURE
<222>  (2)..(3)
<223>  X = F, W, or Y

<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  X = D, E, W, N, Q, or G

<220>
<221>  MISC_FEATURE
<222>  (5)..(5)
<223>  X = V, M, or A

<220>
<221>  MISC_FEATURE
<222>  (7)..(7)
<223>  X = Q, P, E, L, H, R, or A

<220>
<221>  MISC_FEATURE
<222>  (8)..(8)
<223>  X = G, A, V, or R

<220>
<221>  MISC_FEATURE
<222>  (9)..(9)
<223>  X = D, N, or E

<220>
<221>  MISC_FEATURE
<222>  (13)..(13)
<223>  X = Y, W, or H

<400>  19

Xaa Xaa Xaa Xaa Xaa Cys Xaa Xaa Xaa Gly Thr Cys Xaa Gly Gly Gly 
1               5                   10                  15      


<210>  20
<211>  16
<212>  PRT
<213>  Synthetic


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  X = S, N, T, I, V, or G

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  X = F or Y

<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  X = D, E, W, N, Q, or G

<220>
<221>  MISC_FEATURE
<222>  (5)..(5)
<223>  X = V, M, or A

<220>
<221>  MISC_FEATURE
<222>  (7)..(7)
<223>  X = Q, P, E, L, H, R, or A

<220>
<221>  MISC_FEATURE
<222>  (8)..(8)
<223>  X = G, A, V, or R

<220>
<221>  MISC_FEATURE
<222>  (9)..(9)
<223>  X = D, N, or E

<220>
<221>  MISC_FEATURE
<222>  (13)..(13)
<223>  X = Y, W, or H

<400>  20

Xaa Xaa Trp Xaa Xaa Cys Xaa Xaa Xaa Gly Thr Cys Xaa Gly Gly Gly 
1               5                   10                  15      


<210>  21
<211>  20
<212>  PRT
<213>  Synthetic

<400>  21

Ser Ser Gly Ser Asp Pro Ser Ser Ser Trp Phe Pro Pro Pro Val Trp 
1               5                   10                  15      


Phe Ser Ser Arg 
            20  


<210>  22
<211>  13
<212>  PRT
<213>  Synthetic

<400>  22

Ser Ser Leu Ala Ala Trp Tyr Ser Ser Trp Gly Val Ser 
1               5                   10              


<210>  23
<211>  20
<212>  PRT
<213>  Synthetic

<400>  23

Ser Glu Ala Thr Gln Ala Ser Arg Asn Trp Glu Gly Ile Arg Val Phe 
1               5                   10                  15      


Leu Ala Ser Arg 
            20  


<210>  24
<211>  13
<212>  PRT
<213>  Synthetic

<400>  24

Ser Glu Trp Asp Gln Tyr Tyr Ser Tyr Tyr Leu Glu His 
1               5                   10              


<210>  25
<211>  13
<212>  PRT
<213>  Synthetic

<400>  25

Ser Pro Trp Val Thr Trp Tyr Tyr Ser Ala Ser Ser Pro 
1               5                   10              


<210>  26
<211>  16
<212>  PRT
<213>  Synthetic

<400>  26

Ser Thr Met Leu Ser Trp Asp His Val Asn Leu Tyr Tyr Thr Met His 
1               5                   10                  15      


<210>  27
<211>  16
<212>  PRT
<213>  Synthetic

<400>  27

Ser Pro Leu Leu His Trp Asn Lys Ile Gln Asp Tyr Tyr Arg Leu Asn 
1               5                   10                  15      


<210>  28
<211>  13
<212>  PRT
<213>  Synthetic


<220>
<221>  MISC_FEATURE
<222>  (1)..(2)
<223>  X = S, T, G, or P

<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  X = Y, W, or F

<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  X = A, V, I, or L

<220>
<221>  MISC_FEATURE
<222>  (5)..(5)
<223>  X = S, T, G, or P

<220>
<221>  MISC_FEATURE
<222>  (6)..(8)
<223>  X = Y, W, or F

<220>
<221>  MISC_FEATURE
<222>  (9)..(9)
<223>  X = S, T, G, or P

<220>
<221>  MISC_FEATURE
<222>  (10)..(10)
<223>  X = A, V, I, or L

<220>
<221>  MISC_FEATURE
<222>  (11)..(13)
<223>  X =S, T, G, or P

<400>  28

Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
1               5                   10              


<210>  29
<211>  15
<212>  PRT
<213>  Synthetic

<400>  29

Asp Asp Ser Pro Trp Val Thr Trp Tyr Tyr Ser Ala Ser Ser Pro 
1               5                   10                  15  


<210>  30
<211>  17
<212>  PRT
<213>  Synthetic

<400>  30

Asp Asp Asp Asp Ser Pro Trp Val Thr Trp Tyr Tyr Ser Ala Ser Ser 
1               5                   10                  15      


Pro 
    


<210>  31
<211>  17
<212>  PRT
<213>  Synthetic

<400>  31

Asp Glu Asp Glu Ser Pro Trp Val Thr Trp Tyr Tyr Ser Ala Ser Ser 
1               5                   10                  15      


Pro 
    


<210>  32
<211>  19
<212>  PRT
<213>  Synthetic

<400>  32

Asp Glu Asp Glu Asp Glu Ser Pro Trp Val Thr Trp Tyr Tyr Ser Ala 
1               5                   10                  15      


Ser Ser Pro 
            


<210>  33
<211>  9
<212>  PRT
<213>  Synthetic

<400>  33

Ser Pro Trp Val Thr Trp Tyr Tyr Ser 
1               5                   


<210>  34
<211>  11
<212>  PRT
<213>  Synthetic

<400>  34

Trp Val Thr Trp Tyr Tyr Ser Ala Ser Ser Pro 
1               5                   10      


<210>  35
<211>  9
<212>  PRT
<213>  Synthetic

<400>  35

Thr Trp Tyr Tyr Ser Ala Ser Ser Pro 
1               5                   


<210>  36
<211>  11
<212>  PRT
<213>  Synthetic

<400>  36

Ser Pro Trp Val Thr Trp Tyr Tyr Ser Ala Ser 
1               5                   10      


<210>  37
<211>  7
<212>  PRT
<213>  Synthetic

<400>  37

Ser Pro Trp Val Thr Trp Tyr 
1               5           


<210>  38
<211>  9
<212>  PRT
<213>  Synthetic


<220>
<221>  MISC_FEATURE
<222>  (1)..(2)
<223>  X = S, T, G, or P

<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  X  is modified with a Tag1 which is 0-6 residues of either D 
       and/or E but the polypeptide can only have a Tag1 or a Tag2 not 
       both

<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  X  = Y, W, or F

<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  X  = A, V, I, or L

<220>
<221>  MISC_FEATURE
<222>  (5)..(5)
<223>  X  = S, T, G, or P

<220>
<221>  MISC_FEATURE
<222>  (6)..(8)
<223>  X  = Y, W, or F

<220>
<221>  MISC_FEATURE
<222>  (9)..(9)
<223>  X  is modified with a Tag2 which is 0-6 residues of either D 
       and/or E but the polypeptide can only have a Tag1 or a Tag2 not 
       both

<220>
<221>  MISC_FEATURE
<222>  (9)..(9)
<223>  X  = S, T, G, or P

<400>  38

Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
1               5                   


<210>  39
<211>  9
<212>  PRT
<213>  Synthetic


<220>
<221>  MISC_FEATURE
<222>  (1)..(2)
<223>  X = S, T, G, or P

<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  X is modified with Tag1 which is 0-6 residues of D and/or E

<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  X = Y, W, or F

<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  X = A, V, I, or L

<220>
<221>  MISC_FEATURE
<222>  (5)..(5)
<223>  X = S, T, G, or P

<220>
<221>  MISC_FEATURE
<222>  (6)..(8)
<223>  X = Y, W, or F

<220>
<221>  MISC_FEATURE
<222>  (9)..(9)
<223>  X = S, T, G, or P

<400>  39

Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
1               5                   


<210>  40
<211>  21
<212>  PRT
<213>  Synthetic

<400>  40

Ser Ser Gly Pro Arg Glu Ile Trp Asp Ser Leu Val Gly Val Val Asn 
1               5                   10                  15      


Pro Gly Trp Ser Arg 
            20      


<210>  41
<211>  21
<212>  PRT
<213>  Synthetic

<400>  41

Ser Ser Gly Gly Val Gly Gly Trp Ala Leu Phe Glu Thr Leu Arg Gly 
1               5                   10                  15      


Lys Glu Val Ser Arg 
            20      


<210>  42
<211>  21
<212>  PRT
<213>  Synthetic

<400>  42

Ser Ser Val Ala Glu Trp Ala Leu Arg Ser Trp Glu Gly Met Arg Val 
1               5                   10                  15      


Gly Glu Ala Ser Arg 
            20      


<210>  43
<211>  12
<212>  PRT
<213>  Synthetic


<220>
<221>  MISC_FEATURE
<222>  (2)..(3)
<223>  X = any amino acid

<220>
<221>  MISC_FEATURE
<222>  (6)..(6)
<223>  X = S or T

<220>
<221>  MISC_FEATURE
<222>  (8)..(8)
<223>  X = any amino acid

<220>
<221>  MISC_FEATURE
<222>  (10)..(10)
<223>  X = any amino acid

<220>
<221>  MISC_FEATURE
<222>  (12)..(12)
<223>  X = any amino acid

<400>  43

Trp Xaa Xaa Phe Glu Xaa Leu Xaa Gly Xaa Glu Xaa 
1               5                   10          


