                         SEQUENCE LISTING

<110>  Solis BioDyne
       Kahre, Olev
       Artma, Kadri
       Kahre, Tiina
 
<120>  Compositions for Increasing Polypeptide Stability and Activity, 
       and Related Methods

<130>  SMK/FP6734677

<140>  To be Assigned
<141>  2010-11-19

<150>  61/390,857
<151>  2010-10-07

<150>  61/356,541
<151>  2010-06-18

<150>  61/350,457
<151>  2010-06-01

<150>  61/262,919
<151>  2009-11-19

<160>  23    

<170>  PatentIn version 3.5

<210>  1
<211>  42
<212>  PRT
<213>  Synthetic polypeptide

<400>  1

Met Ile Asp Leu Gln Arg Pro Ser Ala Ala Thr Met Val Asp Asp Leu 
1               5                   10                  15      


Gln Arg Pro His His His His His His Pro Trp Asp Tyr Lys Asp Asp 
            20                  25                  30          


Asp Asp Lys Pro Arg Trp Asn Ser Gly Trp 
        35                  40          


<210>  2
<211>  870
<212>  PRT
<213>  Synthetic polypeptide

<400>  2

Met Ile Asp Leu Gln Arg Pro Ser Ala Ala Thr Met Val Asp Asp Leu 
1               5                   10                  15      


Gln Arg Pro His His His His His His Pro Trp Asp Tyr Lys Asp Asp 
            20                  25                  30          


Asp Asp Lys Pro Arg Trp Asn Ser Gly Trp Leu Pro Leu Phe Glu Pro 
        35                  40                  45              


Lys Gly Arg Val Leu Leu Val Asp Gly His His Leu Ala Tyr Arg Thr 
    50                  55                  60                  


Phe His Ala Leu Lys Gly Leu Thr Thr Ser Arg Gly Glu Pro Val Gln 
65                  70                  75                  80  


Ala Val Tyr Gly Phe Ala Lys Ser Leu Leu Lys Ala Leu Lys Glu Asp 
                85                  90                  95      


Gly Asp Ala Val Ile Val Val Phe Asp Ala Lys Ala Pro Ser Phe Arg 
            100                 105                 110         


His Glu Ala Tyr Gly Gly Tyr Lys Ala Gly Arg Ala Pro Thr Pro Glu 
        115                 120                 125             


Asp Phe Pro Arg Gln Leu Ala Leu Ile Lys Glu Leu Val Asp Leu Leu 
    130                 135                 140                 


Gly Leu Ala Arg Leu Glu Val Pro Gly Tyr Glu Ala Asp Asp Val Leu 
145                 150                 155                 160 


Ala Ser Leu Ala Lys Lys Ala Glu Lys Glu Gly Tyr Glu Val Arg Ile 
                165                 170                 175     


Leu Thr Ala Asp Lys Asp Leu Tyr Gln Leu Leu Ser Asp Arg Ile His 
            180                 185                 190         


Val Leu His Pro Glu Gly Tyr Leu Ile Thr Pro Ala Trp Leu Trp Glu 
        195                 200                 205             


Lys Tyr Gly Leu Arg Pro Asp Gln Trp Ala Asp Tyr Arg Ala Leu Thr 
    210                 215                 220                 


Gly Asp Glu Ser Asp Asn Leu Pro Gly Val Lys Gly Ile Gly Glu Lys 
225                 230                 235                 240 


Thr Ala Arg Lys Leu Leu Glu Glu Trp Gly Ser Leu Glu Ala Leu Leu 
                245                 250                 255     


Lys Asn Leu Asp Arg Leu Lys Pro Ala Ile Arg Glu Lys Ile Leu Ala 
            260                 265                 270         


His Met Asp Asp Leu Lys Leu Ser Trp Asp Leu Ala Lys Val Arg Thr 
        275                 280                 285             


Asp Leu Pro Leu Glu Val Asp Phe Ala Lys Arg Arg Glu Pro Asp Arg 
    290                 295                 300                 


Glu Arg Leu Arg Ala Phe Leu Glu Arg Leu Glu Phe Gly Ser Leu Leu 
305                 310                 315                 320 


His Glu Phe Gly Leu Leu Glu Ser Pro Lys Ala Leu Glu Glu Ala Pro 
                325                 330                 335     


Trp Pro Pro Pro Glu Gly Ala Phe Val Gly Phe Val Leu Ser Arg Lys 
            340                 345                 350         


Glu Pro Met Trp Ala Asp Leu Leu Ala Leu Ala Ala Ala Arg Gly Gly 
        355                 360                 365             


Arg Val His Arg Ala Pro Glu Pro Tyr Lys Ala Leu Arg Asp Leu Lys 
    370                 375                 380                 


Glu Ala Arg Gly Leu Leu Ala Lys Asp Leu Ser Val Leu Ala Leu Arg 
385                 390                 395                 400 


Glu Gly Leu Gly Leu Pro Pro Gly Asp Asp Pro Met Leu Leu Ala Tyr 
                405                 410                 415     


Leu Leu Asp Pro Ser Asn Thr Thr Pro Glu Gly Val Ala Arg Arg Tyr 
            420                 425                 430         


Gly Gly Glu Trp Thr Glu Glu Ala Gly Glu Arg Ala Ala Leu Ser Glu 
        435                 440                 445             


Arg Leu Phe Ala Asn Leu Trp Gly Arg Leu Glu Gly Glu Glu Arg Leu 
    450                 455                 460                 


Leu Trp Leu Tyr Arg Glu Val Glu Arg Pro Leu Ser Ala Val Leu Ala 
465                 470                 475                 480 


His Met Glu Ala Thr Gly Val Arg Leu Asp Val Ala Tyr Leu Arg Ala 
                485                 490                 495     


Leu Ser Leu Glu Val Ala Glu Glu Ile Ala Arg Leu Glu Ala Glu Val 
            500                 505                 510         


Phe Arg Leu Ala Gly His Pro Phe Asn Leu Asn Ser Arg Asp Gln Leu 
        515                 520                 525             


Glu Arg Val Leu Phe Asp Glu Leu Gly Leu Pro Ala Ile Gly Lys Thr 
    530                 535                 540                 


Glu Lys Thr Gly Lys Arg Ser Thr Ser Ala Ala Val Leu Glu Ala Leu 
545                 550                 555                 560 


Arg Glu Ala His Pro Ile Val Glu Lys Ile Leu Gln Tyr Arg Glu Leu 
                565                 570                 575     


Thr Lys Leu Lys Ser Thr Tyr Ile Asp Pro Leu Pro Asp Leu Ile His 
            580                 585                 590         


Pro Arg Thr Gly Arg Leu His Thr Arg Phe Asn Gln Thr Ala Thr Ala 
        595                 600                 605             


Thr Gly Arg Leu Ser Ser Ser Asp Pro Asn Leu Gln Asn Ile Pro Val 
    610                 615                 620                 


Arg Thr Pro Leu Gly Gln Arg Ile Arg Arg Ala Phe Ile Ala Glu Glu 
625                 630                 635                 640 


Gly Trp Leu Leu Val Ala Leu Asp Tyr Ser Gln Ile Glu Leu Arg Val 
                645                 650                 655     


Leu Ala His Leu Ser Gly Asp Glu Asn Leu Ile Arg Val Phe Gln Glu 
            660                 665                 670         


Gly Arg Asp Ile His Thr Glu Thr Ala Ser Trp Met Phe Gly Val Pro 
        675                 680                 685             


Arg Glu Ala Val Asp Pro Leu Met Arg Arg Ala Ala Lys Thr Ile Asn 
    690                 695                 700                 


Phe Gly Val Leu Tyr Gly Met Ser Ala His Arg Leu Ser Gln Glu Leu 
705                 710                 715                 720 


Ala Ile Pro Tyr Glu Glu Ala Gln Ala Phe Ile Glu Arg Tyr Phe Gln 
                725                 730                 735     


Ser Phe Pro Lys Val Arg Ala Trp Ile Glu Lys Thr Leu Glu Glu Gly 
            740                 745                 750         


Arg Arg Arg Gly Tyr Val Glu Thr Leu Phe Gly Arg Arg Arg Tyr Val 
        755                 760                 765             


Pro Asp Leu Glu Ala Arg Val Lys Ser Val Arg Glu Ala Ala Glu Arg 
    770                 775                 780                 


Met Ala Phe Asn Met Pro Val Gln Gly Thr Ala Ala Asp Leu Met Lys 
785                 790                 795                 800 


Leu Ala Met Val Lys Leu Phe Pro Arg Leu Glu Glu Met Gly Ala Arg 
                805                 810                 815     


Met Leu Leu Gln Val His Asp Glu Leu Val Leu Glu Ala Pro Lys Glu 
            820                 825                 830         


Arg Ala Glu Ala Val Ala Arg Leu Ala Lys Glu Val Met Glu Gly Val 
        835                 840                 845             


Tyr Pro Leu Ala Val Pro Leu Glu Val Glu Val Gly Ile Gly Glu Asp 
    850                 855                 860                 


Trp Leu Ser Ala Lys Glu 
865                 870 


<210>  3
<211>  141
<212>  DNA
<213>  Synthetic polynucleotide

<400>  3
acacaggaaa cagcgatgat cgacctgcag cggccatccg ccgccaccat ggtcgacgac       60

ctgcagcggc cgcaccatca ccatcaccat ccatgggatt acaaggacga cgatgacaag      120

ccgcggtgga attcggggtg g                                                141


<210>  4
<211>  2637
<212>  DNA
<213>  Synthetic polynucleotide

<400>  4
acacaggaaa cagcgatgat cgacctgcag cggccatccg ccgccaccat ggtcgacgac       60

ctgcagcggc cgcaccatca ccatcaccat ccatgggatt acaaggacga cgatgacaag      120

ccgcggtgga attcggggtg gctgcccctc tttgagccca agggccgggt cctcctggtg      180

gacggccacc acctggccta ccgcaccttc cacgccctga agggcctcac caccagccgg      240

ggggagccgg tgcaggcggt ctacggcttc gccaagagcc tcctcaaggc cctcaaggag      300

gacggggacg cggtgatcgt ggtctttgac gccaaggccc cctccttccg ccacgaggcc      360

tacggggggt acaaggcggg ccgggccccc acgccggagg actttccccg gcaactcgcc      420

ctcatcaagg agctggtgga cctcctgggg ctggcgcgcc tcgaggtccc gggctacgag      480

gcggacgacg tcctggccag cctggccaag aaggcggaaa aggagggcta cgaggtccgc      540

atcctcaccg ccgacaaaga cctttaccag ctcctttccg accgcatcca cgtcctccac      600

cccgaggggt acctcatcac cccggcctgg ctttgggaaa agtacggcct gaggcccgac      660

cagtgggccg actaccgggc cctgaccggg gacgagtccg acaaccttcc cggggtcaag      720

ggcatcgggg agaagacggc gaggaagctt ctggaggagt gggggagcct ggaagccctc      780

ctcaagaacc tggaccggct gaagcccgcc atccgggaga agatcctggc ccacatggac      840

gatctgaagc tctcctggga cctggccaag gtgcgcaccg acctgcccct ggaggtggac      900

ttcgccaaaa ggcgggagcc cgaccgggag aggcttaggg cctttctgga gaggcttgag      960

tttggcagcc tcctccacga gttcggcctt ctggaaagcc ccaaggccct ggaggaggcc     1020

ccctggcccc cgccggaagg ggccttcgtg ggctttgtgc tttcccgcaa ggagcccatg     1080

tgggccgatc ttctggccct ggccgccgcc agggggggcc gggtccaccg ggcccccgag     1140

ccttataaag ccctcaggga cctgaaggag gcgcgggggc ttctcgccaa agacctgagc     1200

gttctggccc tgagggaagg ccttggcctc ccgcccggcg acgaccccat gctcctcgcc     1260

tacctcctgg acccttccaa caccaccccc gagggggtgg cccggcgcta cggcggggag     1320

tggacggagg aggcggggga gcgggccgcc ctttccgaga ggctcttcgc caacctgtgg     1380

gggaggcttg agggggagga gaggctcctt tggctttacc gggaggtgga gaggcccctt     1440

tccgctgtcc tggcccacat ggaggccacg ggggtgcgcc tggacgtggc ctatctcagg     1500

gccttgtccc tggaggtggc cgaggagatc gcccgcctcg aggccgaggt cttccgcctg     1560

gccggccacc ccttcaacct caactcccgg gaccagctgg aaagggtcct ctttgacgag     1620

ctagggcttc ccgccatcgg caagacggag aagaccggca agcgctccac cagcgccgcc     1680

gtcctggagg ccctccgcga ggcccacccc atcgtggaga agatcctgca gtaccgggag     1740

ctcaccaagc tgaagagcac ctacattgac cccttgccgg acctcatcca ccccaggacg     1800

ggccgcctcc acacccgctt caaccagacg gccacggcca cgggcaggct aagtagctcc     1860

gatcccaacc tccagaacat ccccgtccgc accccgcttg ggcagaggat ccgccgggcc     1920

ttcatcgccg aggaggggtg gctattggtg gccctggact atagccagat agagctcagg     1980

gtgctggccc acctctccgg cgacgagaac ctgatccggg tcttccagga ggggcgggac     2040

atccacacgg agaccgccag ctggatgttc ggcgtccccc gggaggccgt ggaccccctg     2100

atgcgccggg cggccaagac catcaacttc ggggtcctct acggcatgtc ggcccaccgc     2160

ctctcccagg agctagccat cccttacgag gaggcccagg ccttcattga gcgctacttt     2220

cagagcttcc ccaaggtgcg ggcctggatt gagaagaccc tggaggaggg caggaggcgg     2280

gggtacgtgg agaccctctt cggccgccgc cgctacgtgc cagacctaga ggcccgggtg     2340

aagagcgtgc gggaggcggc cgagcgcatg gccttcaaca tgcccgtcca gggcaccgcc     2400

gccgacctca tgaagctggc tatggtgaag ctcttcccca ggctggagga aatgggggcc     2460

aggatgctcc ttcaggtcca cgacgagctg gtcctcgagg ccccaaaaga gagggcggag     2520

gccgtggccc ggctggccaa ggaggtcatg gagggggtgt atcccctggc cgtgcccctg     2580

gaggtggagg tggggatagg ggaggactgg ctctccgcca aggagtgata gatctga        2637


<210>  5
<211>  2829
<212>  DNA
<213>  Synthetic polynucleotide

<400>  5
acacaggaaa cagcgatgat cgacctgcag cggccgcagg ccgccaccat ggactctaga       60

caccatcacc atcaccaccc atgggattac aaggacgacg atgacaagcc gcggtggaat      120

tcgagcgcaa ccgtaaagtt caagtacaaa ggcgaagaaa aagaggtaga catctccaag      180

atcaagaaag tatggcgtgt gggcaagatg atctccttca cctacgacga gggcggtggc      240

aagaccggcc gcggtgcggt aagcgaaaag gacgcgccga aggagctgct gcagatgctg      300

gagaagcaga aaaagattaa gaattcgggt aacctgcccc tctttgagcc caagggccgg      360

gtcctcctgg tggacggcca ccacctggcc taccgcacct tccacgccct gaagggcctc      420

accaccagcc ggggggagcc ggtgcaggcg gtctacggct tcgccaagag cctcctcaag      480

gccctcaagg aggacgggga cgcggtgatc gtggtctttg acgccaaggc cccctccttc      540

cgccacgagg cctacggggg gtacaaggcg ggccgggccc ccacaccgga ggactttccc      600

cggcaactcg ccctcatcaa ggagctggtg gacctcctgg ggctggcgcg cctcgaggtc      660

ccgggctacg aggcggacga cgtcctggcc agcctggcca agaaggcgga aaaggagggc      720

tacgaggtcc gcatcctcac cgccgacaaa gacctttacc agctcctttc cgaccgcatc      780

cacgtcctcc accccgaggg gtacctcatc accccggcct ggctttggga aaagtacggc      840

ctgaggcccg accagtgggc cgactaccgg gccctgaccg gggacgagtc cgacaacctt      900

cccggggtca agggcatcgg ggagaagacg gcgaggaagc ttctggagga gtgggggagc      960

ctggaagccc tcctcaagaa cctggaccgg ctgaagcccg ccatccggga gaagatcctg     1020

gcccacatgg acgatctgaa gctctcctgg gacctggcca aggtgcgcac cgacctgccc     1080

ctggaggtgg acttcgccaa aaggcgggag cccgaccggg agaggcttag ggcctttctg     1140

gagaggcttg agtttggcag cctcctccac gagttcggcc ttctggaaag ccccaaggcc     1200

ctggaggagg ccccctggcc cccgccggaa ggggccttcg tgggctttgt gctttcccgc     1260

aaggagccca tgtgggccga tcttctggcc ctggccgccg ccaggggggg ccgggtccac     1320

cgggcccccg agccttataa agccctcagg gacctgaagg aggcgcgggg gcttctcgcc     1380

aaagacctga gcgttctggc cctgagggaa ggccttggcc tcccgcccgg cgacgacccc     1440

atgctcctcg cctacctcct ggacccttcc aacaccaccc ccgagggggt ggcccggcgc     1500

tacggcgggg agtggacgga ggaggcgggg gagcgggccg ccctttccga gaggctcttc     1560

gccaacctgt gggggaggct tgagggggag gagaggctcc tttggcttta ccgggaggtg     1620

gagaggcccc tttccgctgt cctggcccac atggaggcca cgggggtgcg cctggacgtg     1680

gcctatctca gggccttgtc cctggaggtg gccgaggaga tcgcccgcct cgaggccgag     1740

gtcttccgcc tggccggcca ccccttcaac ctcaactccc gggaccagct ggaaagggtc     1800

ctctttgacg agctagggct tcccgccatc ggcaagacgg agaagaccgg caagcgctcc     1860

accagcgccg ccgtcctgga ggccctccgc gaggcccacc ccatcgtgga gaagatcctg     1920

cagtaccggg agctcaccaa gctgaagagc acctacattg accccttgcc ggacctcatc     1980

caccccagga cgggccgcct ccacacccgc ttcaaccaga cggccacggc cacgggcagg     2040

ctaagtagct ccgatcccaa cctccagaac atccccgtcc gcaccccgct tgggcagagg     2100

atccgccggg ccttcatcgc cgaggagggg tggctattgg tggccctgga ctatagccag     2160

atagagctca gggtgctggc ccacctctcc ggcgacgaga acctgatccg ggtcttccag     2220

gaggggcggg acatccacac ggagaccgcc agctggatgt tcggcgtccc ccgggaggcc     2280

gtggaccccc tgatgcgccg ggcggccaag accatcaact tcggggtcct ctacggcatg     2340

tcggcccacc gcctctccca ggagctagcc atcccttacg aggaggccca ggccttcatt     2400

gagcgctact ttcagagctt ccccaaggtg cgggcctgga ttgagaagac cctggaggag     2460

ggcaggaggc gggggtacgt ggagaccctc ttcggccgcc gccgctacgt gccagaccta     2520

gaggcccggg tgaagagcgt gcgggaggcg gccgagcgca tggccttcaa catgcccgtc     2580

cagggcaccg ccgccgacct catgaagctg gctatggtga agctcttccc caggctggag     2640

gaaatggggg ccaggatgct ccttcaggtc cacgacgagc tggtcctcga ggccccaaaa     2700

gagagggcgg aggccgtggc ccggctggcc aaggaggtca tggagggggt gtatcccctg     2760

gccgtgcccc tggaggtgga ggtggggata ggggaggact ggctctccgc caaggagtga     2820

tagatctga                                                             2829


<210>  6
<211>  935
<212>  PRT
<213>  Synthetic polypeptide

<400>  6

Met Ile Asp Leu Gln Arg Pro Gln Ala Ala Thr Met Asp Ser Arg His 
1               5                   10                  15      


His His His His His Pro Trp Asp Tyr Lys Asp Asp Asp Asp Lys Pro 
            20                  25                  30          


Arg Trp Asn Ser Ser Ala Thr Val Lys Phe Lys Tyr Lys Gly Glu Glu 
        35                  40                  45              


Lys Glu Val Asp Ile Ser Lys Ile Lys Lys Val Trp Arg Val Gly Lys 
    50                  55                  60                  


Met Ile Ser Phe Thr Tyr Asp Glu Gly Gly Gly Lys Thr Gly Arg Gly 
65                  70                  75                  80  


Ala Val Ser Glu Lys Asp Ala Pro Lys Glu Leu Leu Gln Met Leu Glu 
                85                  90                  95      


Lys Gln Lys Lys Ile Lys Asn Ser Gly Asn Leu Pro Leu Phe Glu Pro 
            100                 105                 110         


Lys Gly Arg Val Leu Leu Val Asp Gly His His Leu Ala Tyr Arg Thr 
        115                 120                 125             


Phe His Ala Leu Lys Gly Leu Thr Thr Ser Arg Gly Glu Pro Val Gln 
    130                 135                 140                 


Ala Val Tyr Gly Phe Ala Lys Ser Leu Leu Lys Ala Leu Lys Glu Asp 
145                 150                 155                 160 


Gly Asp Ala Val Ile Val Val Phe Asp Ala Lys Ala Pro Ser Phe Arg 
                165                 170                 175     


His Glu Ala Tyr Gly Gly Tyr Lys Ala Gly Arg Ala Pro Thr Pro Glu 
            180                 185                 190         


Asp Phe Pro Arg Gln Leu Ala Leu Ile Lys Glu Leu Val Asp Leu Leu 
        195                 200                 205             


Gly Leu Ala Arg Leu Glu Val Pro Gly Tyr Glu Ala Asp Asp Val Leu 
    210                 215                 220                 


Ala Ser Leu Ala Lys Lys Ala Glu Lys Glu Gly Tyr Glu Val Arg Ile 
225                 230                 235                 240 


Leu Thr Ala Asp Lys Asp Leu Tyr Gln Leu Leu Ser Asp Arg Ile His 
                245                 250                 255     


Val Leu His Pro Glu Gly Tyr Leu Ile Thr Pro Ala Trp Leu Trp Glu 
            260                 265                 270         


Lys Tyr Gly Leu Arg Pro Asp Gln Trp Ala Asp Tyr Arg Ala Leu Thr 
        275                 280                 285             


Gly Asp Glu Ser Asp Asn Leu Pro Gly Val Lys Gly Ile Gly Glu Lys 
    290                 295                 300                 


Thr Ala Arg Lys Leu Leu Glu Glu Trp Gly Ser Leu Glu Ala Leu Leu 
305                 310                 315                 320 


Lys Asn Leu Asp Arg Leu Lys Pro Ala Ile Arg Glu Lys Ile Leu Ala 
                325                 330                 335     


His Met Asp Asp Leu Lys Leu Ser Trp Asp Leu Ala Lys Val Arg Thr 
            340                 345                 350         


Asp Leu Pro Leu Glu Val Asp Phe Ala Lys Arg Arg Glu Pro Asp Arg 
        355                 360                 365             


Glu Arg Leu Arg Ala Phe Leu Glu Arg Leu Glu Phe Gly Ser Leu Leu 
    370                 375                 380                 


His Glu Phe Gly Leu Leu Glu Ser Pro Lys Ala Leu Glu Glu Ala Pro 
385                 390                 395                 400 


Trp Pro Pro Pro Glu Gly Ala Phe Val Gly Phe Val Leu Ser Arg Lys 
                405                 410                 415     


Glu Pro Met Trp Ala Asp Leu Leu Ala Leu Ala Ala Ala Arg Gly Gly 
            420                 425                 430         


Arg Val His Arg Ala Pro Glu Pro Tyr Lys Ala Leu Arg Asp Leu Lys 
        435                 440                 445             


Glu Ala Arg Gly Leu Leu Ala Lys Asp Leu Ser Val Leu Ala Leu Arg 
    450                 455                 460                 


Glu Gly Leu Gly Leu Pro Pro Gly Asp Asp Pro Met Leu Leu Ala Tyr 
465                 470                 475                 480 


Leu Leu Asp Pro Ser Asn Thr Thr Pro Glu Gly Val Ala Arg Arg Tyr 
                485                 490                 495     


Gly Gly Glu Trp Thr Glu Glu Ala Gly Glu Arg Ala Ala Leu Ser Glu 
            500                 505                 510         


Arg Leu Phe Ala Asn Leu Trp Gly Arg Leu Glu Gly Glu Glu Arg Leu 
        515                 520                 525             


Leu Trp Leu Tyr Arg Glu Val Glu Arg Pro Leu Ser Ala Val Leu Ala 
    530                 535                 540                 


His Met Glu Ala Thr Gly Val Arg Leu Asp Val Ala Tyr Leu Arg Ala 
545                 550                 555                 560 


Leu Ser Leu Glu Val Ala Glu Glu Ile Ala Arg Leu Glu Ala Glu Val 
                565                 570                 575     


Phe Arg Leu Ala Gly His Pro Phe Asn Leu Asn Ser Arg Asp Gln Leu 
            580                 585                 590         


Glu Arg Val Leu Phe Asp Glu Leu Gly Leu Pro Ala Ile Gly Lys Thr 
        595                 600                 605             


Glu Lys Thr Gly Lys Arg Ser Thr Ser Ala Ala Val Leu Glu Ala Leu 
    610                 615                 620                 


Arg Glu Ala His Pro Ile Val Glu Lys Ile Leu Gln Tyr Arg Glu Leu 
625                 630                 635                 640 


Thr Lys Leu Lys Ser Thr Tyr Ile Asp Pro Leu Pro Asp Leu Ile His 
                645                 650                 655     


Pro Arg Thr Gly Arg Leu His Thr Arg Phe Asn Gln Thr Ala Thr Ala 
            660                 665                 670         


Thr Gly Arg Leu Ser Ser Ser Asp Pro Asn Leu Gln Asn Ile Pro Val 
        675                 680                 685             


Arg Thr Pro Leu Gly Gln Arg Ile Arg Arg Ala Phe Ile Ala Glu Glu 
    690                 695                 700                 


Gly Trp Leu Leu Val Ala Leu Asp Tyr Ser Gln Ile Glu Leu Arg Val 
705                 710                 715                 720 


Leu Ala His Leu Ser Gly Asp Glu Asn Leu Ile Arg Val Phe Gln Glu 
                725                 730                 735     


Gly Arg Asp Ile His Thr Glu Thr Ala Ser Trp Met Phe Gly Val Pro 
            740                 745                 750         


Arg Glu Ala Val Asp Pro Leu Met Arg Arg Ala Ala Lys Thr Ile Asn 
        755                 760                 765             


Phe Gly Val Leu Tyr Gly Met Ser Ala His Arg Leu Ser Gln Glu Leu 
    770                 775                 780                 


Ala Ile Pro Tyr Glu Glu Ala Gln Ala Phe Ile Glu Arg Tyr Phe Gln 
785                 790                 795                 800 


Ser Phe Pro Lys Val Arg Ala Trp Ile Glu Lys Thr Leu Glu Glu Gly 
                805                 810                 815     


Arg Arg Arg Gly Tyr Val Glu Thr Leu Phe Gly Arg Arg Arg Tyr Val 
            820                 825                 830         


Pro Asp Leu Glu Ala Arg Val Lys Ser Val Arg Glu Ala Ala Glu Arg 
        835                 840                 845             


Met Ala Phe Asn Met Pro Val Gln Gly Thr Ala Ala Asp Leu Met Lys 
    850                 855                 860                 


Leu Ala Met Val Lys Leu Phe Pro Arg Leu Glu Glu Met Gly Ala Arg 
865                 870                 875                 880 


Met Leu Leu Gln Val His Asp Glu Leu Val Leu Glu Ala Pro Lys Glu 
                885                 890                 895     


Arg Ala Glu Ala Val Ala Arg Leu Ala Lys Glu Val Met Glu Gly Val 
            900                 905                 910         


Tyr Pro Leu Ala Val Pro Leu Glu Val Glu Val Gly Ile Gly Glu Asp 
        915                 920                 925             


Trp Leu Ser Ala Lys Glu Ile 
    930                 935 


<210>  7
<211>  325
<212>  DNA
<213>  Synthetic polynucleotide

<400>  7
atgatcgacc tgcagcggcc gcaggccgcc accatggact ctagacacca tcaccatcac       60

cacccatggg attacaagga cgacgatgac aagccgcggt ggaattcgag cgcaaccgta      120

aagttcaagt acaaaggcga agaaaaagag gtagacatct ccaagatcaa gaaagtatgg      180

cgtgtgggca agatgatctc cttcacctac gacgagggcg gtggcaagac cggccgcggt      240

gcggtaagcg aaaaggacgc gccgaaggag ctgctgcaga tgctggagaa gcagaaaaag      300

attaagaatt cgggtaacct gcccc                                            325


<210>  8
<211>  106
<212>  PRT
<213>  Description of Artificial Sequence: Synthetic polypeptide

<400>  8

Met Ile Asp Leu Gln Arg Pro Gln Ala Ala Thr Met Asp Ser Arg His 
1               5                   10                  15      


His His His His His Pro Trp Asp Tyr Lys Asp Asp Asp Asp Lys Pro 
            20                  25                  30          


Arg Trp Asn Ser Ser Ala Thr Val Lys Phe Lys Tyr Lys Gly Glu Glu 
        35                  40                  45              


Lys Glu Val Asp Ile Ser Lys Ile Lys Lys Val Trp Arg Val Gly Lys 
    50                  55                  60                  


Met Ile Ser Phe Thr Tyr Asp Glu Gly Gly Gly Lys Thr Gly Arg Gly 
65                  70                  75                  80  


Ala Val Ser Glu Lys Asp Ala Pro Lys Glu Leu Leu Gln Met Leu Glu 
                85                  90                  95      


Lys Gln Lys Lys Ile Lys Asn Ser Gly Asn 
            100                 105     


<210>  9
<211>  204
<212>  DNA
<213>  Synthetic polynucleotide

<400>  9
agcgcaaccg taaagttcaa gtacaaaggc gaagaaaaag aggtagacat ctccaagatc       60

aagaaagtat ggcgtgtggg caagatgatc tccttcacct acgacgaggg cggtggcaag      120

accggccgcg gtgcggtaag cgaaaaggac gcgccgaagg agctgctgca gatgctggag      180

aagcagaaaa agattaagaa ttcg                                             204


<210>  10
<211>  68
<212>  PRT
<213>  Synthetic polypeptide

<400>  10

Ser Ala Thr Val Lys Phe Lys Tyr Lys Gly Glu Glu Lys Glu Val Asp 
1               5                   10                  15      


Ile Ser Lys Ile Lys Lys Val Trp Arg Val Gly Lys Met Ile Ser Phe 
            20                  25                  30          


Thr Tyr Asp Glu Gly Gly Gly Lys Thr Gly Arg Gly Ala Val Ser Glu 
        35                  40                  45              


Lys Asp Ala Pro Lys Glu Leu Leu Gln Met Leu Glu Lys Gln Lys Lys 
    50                  55                  60                  


Ile Lys Asn Ser 
65              


<210>  11
<211>  876
<212>  PRT
<213>  Synthetic polypeptide

<400>  11

Met Ile Asp Leu Gln Arg Pro Gln Ala Ala Thr Met Asp Ser Arg His 
1               5                   10                  15      


His His His His His Pro Trp Asp Tyr Lys Asp Asp Asp Asp Lys Pro 
            20                  25                  30          


Arg Trp Asn Ser Ile Leu Asp Thr Asp Tyr Ile Thr Glu Asp Gly Lys 
        35                  40                  45              


Pro Val Ile Arg Ile Phe Lys Lys Glu Asn Gly Glu Phe Lys Ile Asp 
    50                  55                  60                  


Tyr Asp Arg Asn Phe Glu Pro Tyr Ile Tyr Ala Leu Leu Lys Asp Asp 
65                  70                  75                  80  


Ser Ala Ile Glu Asp Val Lys Lys Ile Thr Ala Glu Arg His Gly Thr 
                85                  90                  95      


Thr Val Arg Val Val Arg Ala Glu Lys Val Lys Lys Lys Phe Leu Gly 
            100                 105                 110         


Arg Pro Ile Glu Val Trp Lys Leu Tyr Phe Thr His Pro Gln Asp Val 
        115                 120                 125             


Pro Ala Ile Arg Asp Lys Ile Lys Glu His Pro Ala Val Val Asp Ile 
    130                 135                 140                 


Tyr Glu Tyr Asp Ile Pro Phe Ala Lys Arg Tyr Leu Ile Asp Lys Gly 
145                 150                 155                 160 


Leu Ile Pro Met Glu Gly Asp Glu Glu Leu Lys Met Leu Ala Phe Asp 
                165                 170                 175     


Ile Glu Thr Leu Tyr His Glu Gly Glu Glu Phe Ala Glu Gly Pro Ile 
            180                 185                 190         


Leu Met Ile Ser Tyr Ala Asp Glu Glu Gly Ala Arg Val Ile Thr Trp 
        195                 200                 205             


Lys Asn Ile Asp Leu Pro Tyr Val Asp Val Val Ser Thr Glu Lys Glu 
    210                 215                 220                 


Met Ile Lys Arg Phe Leu Lys Val Val Lys Glu Lys Asp Pro Asp Val 
225                 230                 235                 240 


Leu Ile Thr Tyr Asn Gly Asp Asn Phe Asp Phe Ala Tyr Leu Lys Lys 
                245                 250                 255     


Arg Ser Glu Lys Leu Gly Val Lys Phe Ile Leu Gly Arg Glu Gly Ser 
            260                 265                 270         


Glu Pro Lys Ile Gln Arg Met Gly Asp Arg Phe Ala Val Glu Val Lys 
        275                 280                 285             


Gly Arg Ile His Phe Asp Leu Tyr Pro Val Ile Arg Arg Thr Ile Asn 
    290                 295                 300                 


Leu Pro Thr Tyr Thr Leu Glu Ala Val Tyr Glu Ala Ile Phe Gly Gln 
305                 310                 315                 320 


Pro Lys Glu Lys Val Tyr Ala Glu Glu Ile Ala Gln Ala Trp Glu Thr 
                325                 330                 335     


Gly Glu Gly Leu Glu Arg Val Ala Arg Tyr Ser Met Glu Asp Ala Lys 
            340                 345                 350         


Val Thr Tyr Glu Leu Gly Lys Glu Phe Phe Pro Met Glu Ala Gln Leu 
        355                 360                 365             


Ser Arg Leu Val Gly Gln Ser Leu Trp Asp Val Ser Arg Ser Ser Thr 
    370                 375                 380                 


Gly Asn Leu Val Glu Trp Phe Leu Leu Arg Lys Ala Tyr Glu Arg Asn 
385                 390                 395                 400 


Glu Leu Ala Pro Asn Lys Pro Asp Glu Arg Glu Leu Ala Arg Arg Arg 
                405                 410                 415     


Glu Ser Tyr Ala Gly Gly Tyr Val Lys Glu Pro Glu Arg Gly Leu Trp 
            420                 425                 430         


Glu Asn Ile Val Tyr Leu Asp Phe Arg Ser Leu Tyr Pro Ser Ile Ile 
        435                 440                 445             


Ile Thr His Asn Val Ser Pro Asp Thr Leu Asn Arg Glu Gly Cys Glu 
    450                 455                 460                 


Glu Tyr Asp Val Ala Pro Gln Val Gly His Lys Phe Cys Lys Asp Phe 
465                 470                 475                 480 


Pro Gly Phe Ile Pro Ser Leu Leu Gly Asp Leu Leu Glu Glu Arg Gln 
                485                 490                 495     


Lys Val Lys Lys Lys Met Lys Ala Thr Ile Asp Pro Ile Glu Lys Lys 
            500                 505                 510         


Leu Leu Asp Tyr Arg Gln Arg Ala Ile Lys Ile Leu Ala Asn Ser Phe 
        515                 520                 525             


Tyr Gly Tyr Tyr Gly Tyr Ala Lys Ala Arg Trp Tyr Cys Lys Glu Cys 
    530                 535                 540                 


Ala Glu Ser Val Thr Ala Trp Gly Arg Gln Tyr Ile Glu Thr Thr Ile 
545                 550                 555                 560 


Arg Glu Ile Glu Glu Lys Phe Gly Phe Lys Val Leu Tyr Ala Asp Thr 
                565                 570                 575     


Asp Gly Phe Phe Ala Thr Ile Pro Gly Ala Asp Ala Glu Thr Val Lys 
            580                 585                 590         


Lys Lys Ala Lys Glu Phe Leu Asp Tyr Ile Asn Ala Lys Leu Pro Gly 
        595                 600                 605             


Leu Leu Glu Leu Glu Tyr Glu Gly Phe Tyr Lys Arg Gly Phe Phe Val 
    610                 615                 620                 


Thr Lys Lys Lys Tyr Ala Val Ile Asp Glu Glu Asp Lys Ile Thr Thr 
625                 630                 635                 640 


Arg Gly Leu Glu Ile Val Arg Arg Asp Trp Ser Glu Ile Ala Lys Glu 
                645                 650                 655     


Thr Gln Ala Arg Val Leu Glu Ala Ile Leu Lys His Gly Asp Val Glu 
            660                 665                 670         


Glu Ala Val Arg Ile Val Lys Glu Val Thr Glu Lys Leu Ser Lys Tyr 
        675                 680                 685             


Glu Val Pro Pro Glu Lys Leu Val Ile Tyr Glu Gln Ile Thr Arg Asp 
    690                 695                 700                 


Leu Lys Asp Tyr Lys Ala Thr Gly Pro His Val Ala Val Ala Lys Arg 
705                 710                 715                 720 


Leu Ala Ala Arg Gly Ile Lys Ile Arg Pro Gly Thr Val Ile Ser Tyr 
                725                 730                 735     


Ile Val Leu Lys Gly Ser Gly Arg Ile Gly Asp Arg Ala Ile Pro Phe 
            740                 745                 750         


Asp Glu Phe Asp Pro Ala Lys His Lys Tyr Asn Ala Glu Tyr Tyr Ile 
        755                 760                 765             


Glu Asn Gln Val Leu Pro Ala Val Glu Arg Ile Leu Arg Ala Phe Gly 
    770                 775                 780                 


Tyr Arg Lys Glu Asp Leu Arg Tyr Gln Lys Thr Arg Gln Val Gly Leu 
785                 790                 795                 800 


Gly Ala Trp Leu Lys Pro Lys Thr Ser Trp Ile Cys Ala Thr Val Lys 
                805                 810                 815     


Phe Lys Tyr Lys Gly Glu Glu Lys Glu Val Asp Ile Ser Lys Ile Lys 
            820                 825                 830         


Lys Val Trp Arg Val Gly Lys Met Ile Ser Phe Thr Tyr Asp Glu Gly 
        835                 840                 845             


Gly Gly Lys Thr Gly Arg Gly Ala Val Ser Glu Lys Asp Ala Pro Lys 
    850                 855                 860                 


Glu Leu Leu Gln Met Leu Glu Lys Gln Lys Lys Ile 
865                 870                 875     


<210>  12
<211>  2634
<212>  DNA
<213>  Synthetic polynucleotide

<400>  12
atgatcgacc tgcagcggcc gcaggccgcc accatggact ctagacacca tcaccatcac       60

cacccatggg attacaagga cgacgatgac aagccgcggt ggaattccat cctcgataca      120

gactacataa ctgaggatgg aaagcccgtc atcaggatct tcaagaagga gaacggcgag      180

ttcaaaatag actacgacag aaactttgag ccatacatct acgcgctctt gaaggacgac      240

tctgcgattg aggacgtcaa gaagataact gccgagaggc acggcactac cgttagggtt      300

gtcagggccg agaaagtgaa gaagaagttc ctaggcaggc cgatagaggt ctggaagctc      360

tacttcactc acccccagga cgttcccgca atcagggaca agataaagga gcatcctgcc      420

gttgtggaca tctacgagta cgacatcccc ttcgcgaagc gctacctcat agacaaaggc      480

ttaatcccga tggagggcga cgaggaactt aagatgctcg ccttcgacat cgagacgctc      540

tatcacgagg gcgaggagtt cgccgaaggg cctatcctga tgataagcta cgccgacgag      600

gaaggggcgc gcgttattac ctggaagaat atcgaccttc cctatgtcga cgtcgtttcc      660

accgagaagg agatgataaa gcgcttcctc aaggtcgtca aggaaaagga tcccgacgtc      720

ctcataacct acaacggcga caacttcgac ttcgcctacc tcaagaagcg ctccgagaag      780

ctcggagtca agttcatcct cggaagggaa gggagcgagc cgaaaatcca gcgcatgggc      840

gatcgctttg cggtggaggt caagggaagg attcacttcg acctctaccc cgtcattagg      900

agaacgatta acctccccac ttacaccctt gaggcagtat atgaagccat ctttggacag      960

ccgaaggaga aggtctacgc tgaggagata gcgcaggcct gggaaacggg cgagggatta     1020

gaaagggtgg cccgctactc gatggaggac gcaaaggtaa cctatgaact cggaaaagag     1080

ttcttcccta tggaagccca gctctcgcgc ctcgtaggcc agagcctctg ggatgtatct     1140

cgctcgagta ccggaaacct cgtcgagtgg tttttgctga ggaaggccta cgagaggaat     1200

gaacttgcac caaacaagcc ggacgagagg gagctggcaa gaagaaggga gagctacgcg     1260

ggtggatacg tcaaggagcc cgaaagggga ctgtgggaga acatcgtgta tctggacttc     1320

cgctccctgt atccttcgat aataatcacc cataacgtct cccctgatac actcaacagg     1380

gagggttgtg aggagtacga cgtggctcct caggtaggcc ataagttctg caaggacttc     1440

cccggcttca tcccaagcct cctcggggac ctcttggagg agagacagaa ggtaaagaag     1500

aagatgaagg ccactataga cccaatcgag aagaaactcc tcgattacag gcagcgagca     1560

atcaaaatcc ttgctaatag cttctacggt tactacggct atgcaaaggc ccgctggtac     1620

tgcaaggagt gcgccgagag cgttaccgct tggggcaggc agtacatcga gaccacgata     1680

agggaaatag aggagaaatt tggctttaaa gtcctctacg cggacacaga tggatttttc     1740

gcaacaatac ctggagcgga cgccgaaacc gtcaaaaaga aggcaaagga gttcctggac     1800

tacatcaacg ccaaactgcc cggcctgctc gaactcgaat acgagggctt ctacaagcgc     1860

ggcttcttcg tgacgaagaa gaagtacgcg gttatagacg aggaggacaa gataacgacg     1920

cgcgggcttg aaatagttag gcgtgactgg agcgagatag cgaaggagac gcaggcgagg     1980

gttcttgagg cgatactaaa gcacggtgac gttgaagaag cggtaaggat tgtcaaagag     2040

gttacggaga agctgagcaa gtacgaggtt ccaccggaga agctggtcat ctacgagcag     2100

ataacccgcg acctgaagga ctacaaggcc accgggccgc atgtggctgt tgcaaaacgc     2160

ctcgccgcaa gggggataaa aatccggccc ggaacggtca taagctacat cgtgctcaaa     2220

ggctcgggaa ggattgggga cagggctata ccctttgacg aatttgaccc ggcaaagcac     2280

aagtacaatg cagaatacta catcgagaac caggttcttc cagctgtgga gaggattctg     2340

agggcctttg gttaccgtaa agaagattta aggtatcaga aaacgcggca ggttggcttg     2400

ggggcgtggc taaaacctaa gacaagctgg atctgcgcaa ccgtaaagtt caagtacaaa     2460

ggcgaagaaa aagaggtaga catctccaag atcaagaaag tatggcgtgt gggcaagatg     2520

atctccttca cctacgacga gggcggtggc aagaccggcc gcggtgcggt aagcgaaaag     2580

gacgcgccga aggagctgct gcagatgctg gagaagcaga aaaagattta gtgg           2634


<210>  13
<211>  31
<212>  PRT
<213>  Synthetic polypeptide

<400>  13

Met Val Asp Asp Leu Gln Arg Pro His His His His His His Pro Trp 
1               5                   10                  15      


Asp Tyr Lys Asp Asp Asp Asp Lys Pro Arg Trp Asn Ser Gly Trp 
            20                  25                  30      


<210>  14
<211>  36
<212>  PRT
<213>  Synthetic polypeptide

<400>  14

Met Ile Asp Leu Gln Arg Pro Gln Ala Ala Thr Met Asp Ser Arg His 
1               5                   10                  15      


His His His His His Pro Trp Asp Tyr Lys Asp Asp Asp Asp Lys Pro 
            20                  25                  30          


Arg Trp Asn Ser 
        35      


<210>  15
<211>  108
<212>  DNA
<213>  Synthetic polynucleotide

<400>  15
atgatcgacc tgcagcggcc gcaggccgcc accatggact ctagacacca tcaccatcac       60

cacccatggg attacaagga cgacgatgac aagccgcggt ggaattcc                   108


<210>  16
<211>  40
<212>  PRT
<213>  Synthetic polypeptide

<400>  16

Met Ile Asp Leu Gln Arg Pro Ser Ala Ala Thr Met Val Asp Asp Leu 
1               5                   10                  15      


Gln Arg Pro His His His His His His Pro Trp Asp Tyr Lys Asp Asp 
            20                  25                  30          


Asp Asp Lys Pro Arg Trp Asn Ser 
        35                  40  


<210>  17
<211>  120
<212>  DNA
<213>  Synthetic polynucleotide

<400>  17
atgatcgacc tgcagcggcc atccgccgcc accatggtcg acgacctgca gcggccgcac       60

catcaccatc accatccatg ggattacaag gacgacgatg acaagccgcg gtggaattcg      120


<210>  18
<211>  29
<212>  PRT
<213>  Synthetic polypeptide

<400>  18

Met Val Asp Asp Leu Gln Arg Pro His His His His His His Pro Trp 
1               5                   10                  15      


Asp Tyr Lys Asp Asp Asp Asp Lys Pro Arg Trp Asn Ser 
            20                  25                  


<210>  19
<211>  87
<212>  DNA
<213>  Description of Artificial Sequence: Synthetic polynucleotide

<400>  19
atggtcgacg acctgcagcg gccgcaccat caccatcacc atccatggga ttacaaggac       60

gacgatgaca agccgcggtg gaattcg                                           87


<210>  20
<211>  207
<212>  PRT
<213>  Synthetic polypeptide

<400>  20

Met Ile Asp Leu Gln Arg Pro Ser Ala Ala Thr Met Val Asp Asp Leu 
1               5                   10                  15      


Gln Arg Pro His His His His His His Pro Trp Asp Tyr Lys Asp Asp 
            20                  25                  30          


Asp Asp Lys Pro Arg Trp Asn Ser Gly Ala Pro Pro Arg Leu Ile Cys 
        35                  40                  45              


Asp Ser Arg Val Leu Glu Arg Tyr Leu Leu Glu Ala Lys Glu Ala Glu 
    50                  55                  60                  


Asn Ile Thr Thr Gly Cys Ala Glu His Cys Ser Leu Asn Glu Asn Ile 
65                  70                  75                  80  


Thr Val Pro Asp Thr Lys Val Asn Phe Tyr Ala Trp Lys Arg Met Glu 
                85                  90                  95      


Val Gly Gln Gln Ala Val Glu Val Trp Gln Gly Leu Ala Leu Leu Ser 
            100                 105                 110         


Glu Ala Val Leu Arg Gly Gln Ala Leu Leu Val Asn Ser Ser Gln Pro 
        115                 120                 125             


Trp Glu Pro Leu Gln Leu His Val Asp Lys Ala Val Ser Gly Leu Arg 
    130                 135                 140                 


Ser Leu Thr Thr Leu Leu Arg Ala Leu Gly Ala Gln Lys Glu Ala Ile 
145                 150                 155                 160 


Ser Pro Pro Asp Ala Ala Ser Ala Ala Pro Leu Arg Thr Ile Thr Ala 
                165                 170                 175     


Asp Thr Phe Arg Lys Leu Phe Arg Val Tyr Ser Asn Phe Leu Arg Gly 
            180                 185                 190         


Lys Leu Lys Leu Tyr Thr Gly Glu Ala Cys Arg Thr Gly Asp Arg 
        195                 200                 205         


<210>  21
<211>  621
<212>  DNA
<213>  Synthetic polynucleotide

<400>  21
atgatcgacc tgcagcggcc atccgccgcc accatggtcg acgacctgca gcggccgcac       60

catcaccatc accatccatg ggattacaag gacgacgatg acaagccgcg gtggaattcg      120

ggggccccac cacgcctcat ctgtgacagc cgagtcctgg agaggtacct cttggaggcc      180

aaggaggccg agaatatcac gacgggctgt gctgaacact gcagcttgaa tgagaatatc      240

actgtcccag acaccaaagt taatttctat gcctggaaga ggatggaggt cgggcagcag      300

gccgtagaag tctggcaggg cctggccctg ctgtcggaag ctgtcctgcg gggccaggcc      360

ctgttggtca actcttccca gccgtgggag cccctgcagc tgcatgtgga taaagccgtc      420

agtggccttc gcagcctcac cactctgctt cgggctctgg gagcccagaa ggaagccatc      480

tcccctccag atgcggcctc agctgctcca ctccgaacaa tcactgctga cactttccgc      540

aaactcttcc gagtctactc caatttcctc cggggaaagc tgaagctgta cacaggggag      600

gcctgcagga caggggacag a                                                621


<210>  22
<211>  241
<212>  PRT
<213>  Synthetic polypeptide

<400>  22

Met Ile Asp Leu Gln Arg Pro Ser Ala Ala Thr Met Val Asp Asp Leu 
1               5                   10                  15      


Gln Arg Pro His His His His His His Pro Trp Asp Tyr Lys Asp Asp 
            20                  25                  30          


Asp Asp Lys Pro Arg Trp Asn Ser Lys Val Leu Ala Ala Gly Val Val 
        35                  40                  45              


Pro Leu Leu Leu Val Leu His Trp Lys His Gly Ala Gly Ser Pro Leu 
    50                  55                  60                  


Pro Ile Thr Pro Val Asn Ala Thr Cys Ala Ile Arg His Pro Cys His 
65                  70                  75                  80  


Asn Asn Leu Met Asn Gln Ile Arg Ser Gln Leu Ala Gln Leu Asn Gly 
                85                  90                  95      


Ser Ala Asn Ala Leu Phe Ile Leu Tyr Tyr Thr Ala Gln Gly Glu Pro 
            100                 105                 110         


Phe Pro Asn Asn Leu Asp Lys Leu Cys Gly Pro Asn Val Thr Asp Phe 
        115                 120                 125             


Pro Pro Phe His Ala Asn Gly Thr Glu Lys Ala Lys Leu Val Glu Leu 
    130                 135                 140                 


Tyr Arg Ile Val Val Tyr Leu Gly Thr Ser Leu Gly Asn Ile Thr Arg 
145                 150                 155                 160 


Asp Gln Lys Ile Leu Asn Pro Ser Ala Leu Ser Leu His Ser Lys Leu 
                165                 170                 175     


Asn Ala Thr Ala Asp Ile Leu Arg Gly Leu Leu Ser Asn Val Leu Cys 
            180                 185                 190         


Arg Leu Cys Ser Lys Tyr His Val Gly His Val Asp Val Thr Tyr Gly 
        195                 200                 205             


Pro Asp Thr Ser Gly Lys Asp Val Phe Gln Lys Lys Lys Leu Gly Cys 
    210                 215                 220                 


Gln Leu Leu Gly Lys Tyr Lys Gln Ile Ile Ala Val Leu Ala Gln Ala 
225                 230                 235                 240 


Phe 
    


<210>  23
<211>  723
<212>  DNA
<213>  Synthetic polynucleotide

<400>  23
atgatcgacc tgcagcggcc atccgccgcc accatggtcg acgacctgca gcggccgcac       60

catcaccatc accatccatg ggattacaag gacgacgatg acaagccgcg gtggaattcg      120

aaagtgctgg cggcgggcgt ggtgccgctg ctgctggtgc tgcattggaa acatggcgcg      180

ggcagcccgc tgccgattac cccggtgaac gcgacctgcg cgattcgcca tccgtgccat      240

aacaacctga tgaaccagat tcgcagccag ctggcgcagc tgaacggcag cgcgaacgcg      300

ctgtttattc tgtattatac cgcgcagggc gaaccgtttc cgaacaacct ggataaactg      360

tgcggcccga acgtgaccga ttttccgccg tttcatgcga acggcaccga aaaagcgaaa      420

ctggtggaac tgtatcgcat tgtggtgtat ctgggcacca gcctgggcaa cattacccgc      480

gatcagaaaa ttctgaaccc gagcgcgctg agcctgcata gcaaactgaa cgcgaccgcg      540

gatattctgc gcggcctgct gagcaacgtg ctgtgccgcc tgtgcagcaa atatcatgtg      600

ggccatgtgg atgtgaccta tggcccggat accagcggca aagatgtgtt tcagaaaaaa      660

aaactgggct gccagctgct gggcaaatat aaacagatta ttgcggtgct ggcgcaggcg      720

ttt                                                                    723


