                         SEQUENCE LISTING

<110>  4-Antibody AG
 
<120>  Retroviral vector particles and methods for their generation and use

<130>  P34359PCT 

<140>
<141>

<150>  EP 09176789.7
<151>  2009-11-23

<150>  US 61/263,539
<151>  2009-11-23

<160>  66    

<170>  PatentIn version 3.5

<210>  1
<211>  2031
<212>  DNA
<213>  Friend murine leukemia virus

<220>
<223>  PVC-211 env nucleic acid

<400>  1
atggcgtgtt caacgctctc aaaatcccct aaagataaga ttgacccgcg ggacctccta       60

atccccttaa ttctcttcct gtctctcaaa ggggccagat ccgcagcacc cggctctagc      120

cctcaccagg tctacaatat tacctgggaa gtgaccaatg gggatcggga gacagtatgg      180

gcaatatcag gcaaccaccc tctgtggact tggtggccag acctcacccc agatttgtgt      240

atgttagctc tcagtgggcc gccccactgg gggctagagt atcgggcccc ctattcctcg      300

cccccggggc ccccttgttg ctcagggagc agcgggaaca gggcaggctg cgccagagac      360

tgcgacgagc ccttgacctc cctcacccct cggtgcaaca ctgcctggaa cagacttaag      420

ctggaccagg taactcataa atcgagtggg ggattttatg tctgccccgg gtcacatcgc      480

ccccggaaag ccaagtcctg tgggggtcca gactccttct actgtgcctc ttggggctgc      540

gagacaaccg gtagagcata ctggaagccc tcctcatctt gggactacat cacagtagac      600

aacaatctca ccactaacca ggctgctcag gtatgcaaag acaataagtg gtgcaatccc      660

ttggctatcc agtttacaaa cgccgggaaa caggtcacct catggacaat tggacactat      720

tggggtctac gtctttatgt ctctgggcag gacccggggc ttactttcgg gatccgactc      780

aaatatcaaa atctaggacc tcgggtccca ataggaccga accccgtcct ggcagaccaa      840

ctttcgttcc cgctacctaa tcccctaccc aaacctgcca agtctccctc cgcctctaat      900

tcgactccta cattgatttc cccgtccccc gctcccactc agcccccgcc agcaggaacg      960

ggagacaggt tactaaatct agtacaggga gcttaccagg cactcaacct taccaaccct     1020

gataaaactc aagagtgctg gttatgccta gtgtctgcac ccccctatta cgagggggtt     1080

gcggtcctag gtacttattc caaccatacc tctgccccag ctaactgctc cgcgggctcc     1140

caacacaagc tgaccctgtc cgaagtgact ggacagggac tctgcatagg aacagtccca     1200

aaaactcacc aggccctgtg caacactacc cttaagacag gcaaagggtc ttactatcta     1260

gttgcccccg caggaactat gtgggcatgt aacaccggac tcactccatg cctatccgcc     1320

accgtgctta atcgcaccac tgactactgc gttctcgtag aattatggcc cagggtcacc     1380

taccatcctc ccagttacgt ctatagccag tttgaaaaat cctatagaca taaaagagaa     1440

ccagtgtcct taaccttggc cttattatta ggtgggctaa ctatgggtgg catcgccgcg     1500

ggagtaggga caggaactac cgccctggtc gccacccagc agtttcagca gctccatgct     1560

gccgtacaag atgatctcaa agaagttgaa aagtcaatta ctaacctaga aaagtctctt     1620

acttcattgt ctgaggttgt actgcagaat cgacgaggcc tagacctgtt gttcctaaaa     1680

gaaggaggac tgtgtgctgc cctaaaagaa gaatgttgtt tctatgctga ccatactggc     1740

ctagtaagag atagtatggc caaattaaga gagagactca ctcagagaca aaaactattt     1800

gagtcgagcc aaggatggtt cgaaggattg tttaacagat ccccctggtt taccacgttg     1860

atatccacca tcatggggcc tctcattata ctcctactaa ttctgctttt tggaccctgc     1920

attcttaatc gattagttca atttgttaaa gacaggatct cagtagtcca ggctttagtc     1980

ctgactcaac aataccacca gctaaaacca ctagaatacg agccacaata a              2031


<210>  2
<211>  676
<212>  PRT
<213>  Friend murine leukemia virus

<220>
<223>  PVC-211 env amino acid

<400>  2

Met Ala Cys Ser Thr Leu Ser Lys Ser Pro Lys Asp Lys Ile Asp Pro 
1               5                   10                  15      


Arg Asp Leu Leu Ile Pro Leu Ile Leu Phe Leu Ser Leu Lys Gly Ala 
            20                  25                  30          


Arg Ser Ala Ala Pro Gly Ser Ser Pro His Gln Val Tyr Asn Ile Thr 
        35                  40                  45              


Trp Glu Val Thr Asn Gly Asp Arg Glu Thr Val Trp Ala Ile Ser Gly 
    50                  55                  60                  


Asn His Pro Leu Trp Thr Trp Trp Pro Asp Leu Thr Pro Asp Leu Cys 
65                  70                  75                  80  


Met Leu Ala Leu Ser Gly Pro Pro His Trp Gly Leu Glu Tyr Arg Ala 
                85                  90                  95      


Pro Tyr Ser Ser Pro Pro Gly Pro Pro Cys Cys Ser Gly Ser Ser Gly 
            100                 105                 110         


Asn Arg Ala Gly Cys Ala Arg Asp Cys Asp Glu Pro Leu Thr Ser Leu 
        115                 120                 125             


Thr Pro Arg Cys Asn Thr Ala Trp Asn Arg Leu Lys Leu Asp Gln Val 
    130                 135                 140                 


Thr His Lys Ser Ser Gly Gly Phe Tyr Val Cys Pro Gly Ser His Arg 
145                 150                 155                 160 


Pro Arg Lys Ala Lys Ser Cys Gly Gly Pro Asp Ser Phe Tyr Cys Ala 
                165                 170                 175     


Ser Trp Gly Cys Glu Thr Thr Gly Arg Ala Tyr Trp Lys Pro Ser Ser 
            180                 185                 190         


Ser Trp Asp Tyr Ile Thr Val Asp Asn Asn Leu Thr Thr Asn Gln Ala 
        195                 200                 205             


Ala Gln Val Cys Lys Asp Asn Lys Trp Cys Asn Pro Leu Ala Ile Gln 
    210                 215                 220                 


Phe Thr Asn Ala Gly Lys Gln Val Thr Ser Trp Thr Ile Gly His Tyr 
225                 230                 235                 240 


Trp Gly Leu Arg Leu Tyr Val Ser Gly Gln Asp Pro Gly Leu Thr Phe 
                245                 250                 255     


Gly Ile Arg Leu Lys Tyr Gln Asn Leu Gly Pro Arg Val Pro Ile Gly 
            260                 265                 270         


Pro Asn Pro Val Leu Ala Asp Gln Leu Ser Phe Pro Leu Pro Asn Pro 
        275                 280                 285             


Leu Pro Lys Pro Ala Lys Ser Pro Ser Ala Ser Asn Ser Thr Pro Thr 
    290                 295                 300                 


Leu Ile Ser Pro Ser Pro Ala Pro Thr Gln Pro Pro Pro Ala Gly Thr 
305                 310                 315                 320 


Gly Asp Arg Leu Leu Asn Leu Val Gln Gly Ala Tyr Gln Ala Leu Asn 
                325                 330                 335     


Leu Thr Asn Pro Asp Lys Thr Gln Glu Cys Trp Leu Cys Leu Val Ser 
            340                 345                 350         


Ala Pro Pro Tyr Tyr Glu Gly Val Ala Val Leu Gly Thr Tyr Ser Asn 
        355                 360                 365             


His Thr Ser Ala Pro Ala Asn Cys Ser Ala Gly Ser Gln His Lys Leu 
    370                 375                 380                 


Thr Leu Ser Glu Val Thr Gly Gln Gly Leu Cys Ile Gly Thr Val Pro 
385                 390                 395                 400 


Lys Thr His Gln Ala Leu Cys Asn Thr Thr Leu Lys Thr Gly Lys Gly 
                405                 410                 415     


Ser Tyr Tyr Leu Val Ala Pro Ala Gly Thr Met Trp Ala Cys Asn Thr 
            420                 425                 430         


Gly Leu Thr Pro Cys Leu Ser Ala Thr Val Leu Asn Arg Thr Thr Asp 
        435                 440                 445             


Tyr Cys Val Leu Val Glu Leu Trp Pro Arg Val Thr Tyr His Pro Pro 
    450                 455                 460                 


Ser Tyr Val Tyr Ser Gln Phe Glu Lys Ser Tyr Arg His Lys Arg Glu 
465                 470                 475                 480 


Pro Val Ser Leu Thr Leu Ala Leu Leu Leu Gly Gly Leu Thr Met Gly 
                485                 490                 495     


Gly Ile Ala Ala Gly Val Gly Thr Gly Thr Thr Ala Leu Val Ala Thr 
            500                 505                 510         


Gln Gln Phe Gln Gln Leu His Ala Ala Val Gln Asp Asp Leu Lys Glu 
        515                 520                 525             


Val Glu Lys Ser Ile Thr Asn Leu Glu Lys Ser Leu Thr Ser Leu Ser 
    530                 535                 540                 


Glu Val Val Leu Gln Asn Arg Arg Gly Leu Asp Leu Leu Phe Leu Lys 
545                 550                 555                 560 


Glu Gly Gly Leu Cys Ala Ala Leu Lys Glu Glu Cys Cys Phe Tyr Ala 
                565                 570                 575     


Asp His Thr Gly Leu Val Arg Asp Ser Met Ala Lys Leu Arg Glu Arg 
            580                 585                 590         


Leu Thr Gln Arg Gln Lys Leu Phe Glu Ser Ser Gln Gly Trp Phe Glu 
        595                 600                 605             


Gly Leu Phe Asn Arg Ser Pro Trp Phe Thr Thr Leu Ile Ser Thr Ile 
    610                 615                 620                 


Met Gly Pro Leu Ile Ile Leu Leu Leu Ile Leu Leu Phe Gly Pro Cys 
625                 630                 635                 640 


Ile Leu Asn Arg Leu Val Gln Phe Val Lys Asp Arg Ile Ser Val Val 
                645                 650                 655     


Gln Ala Leu Val Leu Thr Gln Gln Tyr His Gln Leu Lys Pro Leu Glu 
            660                 665                 670         


Tyr Glu Pro Gln 
        675     


<210>  3
<211>  1998
<212>  DNA
<213>  Murine leukemia virus

<220>
<223>  MLV env nucleic acid

<400>  3
atggcgcgtt caacgctctc aaaacccctt aaaaataagg ttaacccgcg aggcccccta       60

atccccttaa ttcttctgat gctcagaggg gtcagtactg cttcgcccgg ctccagtcct      120

catcaagtct ataatatcac ctgggaggta accaatggag atcgggagac ggtatgggca      180

acttctggca accaccctct gtggacctgg tggcctgacc ttaccccaga tttatgtatg      240

ttagcccacc atggaccatc ttattggggg ctagaatatc aatccccttt ttcttctccc      300

ccggggcccc cttgttgctc agggggcagc agcccaggct gttccagaga ctgcgaagaa      360

cctttaacct ccctcacccc tcggtgcaac actgcctgga acagactcaa gctagaccag      420

acaactcata aatcaaatga gggattttat gtttgccccg ggccccaccg cccccgagaa      480

tccaagtcat gtgggggtcc agactccttc tactgtgcct attggggctg tgagacaacc      540

ggtagagctt actggaagcc ctcctcatca tgggatttca tcacagtaaa caacaatctc      600

acctctgacc aggctgtcca ggtatgcaaa gataataagt ggtgcaaccc cttagttatt      660

cggtttacag acgccgggag acgggttact tcctggacca caggacatta ctggggctta      720

cgtttgtatg tctccggaca agatccaggg cttacatttg ggatccgact cagataccaa      780

aatctaggac cccgcgtccc aatagggcca aaccccgttc tggcagacca acagccactc      840

tccaagccca aacctgttaa gtcgccttca gtcaccaaac cacccagtgg gactcctctc      900

tcccctaccc aacttccacc ggcgggaacg gaaaataggc tgctaaactt agtagacgga      960

gcctaccaag ccctcaacct caccagtcct gacaaaaccc aagagtgctg gttgtgtcta     1020

gtagcgggac ccccctacta cgaaggggtt gccgtcctgg gtacctactc caaccatacc     1080

tctgctccag ccaactgctc cgtggcctcc caacacaagt tgaccctgtc cgaagtgacc     1140

ggacagggac tctgcatagg agcagttccc aaaacacatc aggccctatg taataccacc     1200

cagacaagca gtcgagggtc ctattatcta gttgccccta caggtaccat gtgggcttgt     1260

agtaccgggc ttactccatg catctccacc accatactga accttaccac tgattattgt     1320

gttcttgtcg aactctggcc aagagtcacc tatcattccc ccagctatgt ttacggcctg     1380

tttgagagat ccaaccgaca caaaagagaa ccggtgtcgt taaccctggc cctattattg     1440

ggtggactaa ccatgggggg aattgccgct ggaataggaa cagggactac tgctctaatg     1500

gccactcagc aattccagca gctccaagcc gcagtacagg atgatctcag ggaggttgaa     1560

aaatcaatct ctaacctaga aaagtctctc acttccctgt ctgaagttgt cctacagaat     1620

cgaaggggcc tagacttgtt atttctaaaa gaaggagggc tgtgtgctgc tctaaaagaa     1680

gaatgttgct tctatgcgga ccacacagga ctagtgagag acagcatggc caaattgaga     1740

gagaggctta atcagagaca gaaactgttt gagtcaactc aaggatggtt tgagggactg     1800

tttaacagat ccccttggtt taccaccttg atatctacca ttatgggacc cctcattgta     1860

ctcctaatga ttttgctctt cggaccctgc attcttaatc gattagtcca atttgttaaa     1920

gacaggatat cagtggtcca ggctctagtt ttgactcaac aatatcacca gctgaagcct     1980

atagagtacg agccatag                                                   1998


<210>  4
<211>  665
<212>  PRT
<213>  Murine leukemia virus

<220>
<223>  MLV env amino acid

<400>  4

Met Ala Arg Ser Thr Leu Ser Lys Pro Leu Lys Asn Lys Val Asn Pro 
1               5                   10                  15      


Arg Gly Pro Leu Ile Pro Leu Ile Leu Leu Met Leu Arg Gly Val Ser 
            20                  25                  30          


Thr Ala Ser Pro Gly Ser Ser Pro His Gln Val Tyr Asn Ile Thr Trp 
        35                  40                  45              


Glu Val Thr Asn Gly Asp Arg Glu Thr Val Trp Ala Thr Ser Gly Asn 
    50                  55                  60                  


His Pro Leu Trp Thr Trp Trp Pro Asp Leu Thr Pro Asp Leu Cys Met 
65                  70                  75                  80  


Leu Ala His His Gly Pro Ser Tyr Trp Gly Leu Glu Tyr Gln Ser Pro 
                85                  90                  95      


Phe Ser Ser Pro Pro Gly Pro Pro Cys Cys Ser Gly Gly Ser Ser Pro 
            100                 105                 110         


Gly Cys Ser Arg Asp Cys Glu Glu Pro Leu Thr Ser Leu Thr Pro Arg 
        115                 120                 125             


Cys Asn Thr Ala Trp Asn Arg Leu Lys Leu Asp Gln Thr Thr His Lys 
    130                 135                 140                 


Ser Asn Glu Gly Phe Tyr Val Cys Pro Gly Pro His Arg Pro Arg Glu 
145                 150                 155                 160 


Ser Lys Ser Cys Gly Gly Pro Asp Ser Phe Tyr Cys Ala Tyr Trp Gly 
                165                 170                 175     


Cys Glu Thr Thr Gly Arg Ala Tyr Trp Lys Pro Ser Ser Ser Trp Asp 
            180                 185                 190         


Phe Ile Thr Val Asn Asn Asn Leu Thr Ser Asp Gln Ala Val Gln Val 
        195                 200                 205             


Cys Lys Asp Asn Lys Trp Cys Asn Pro Leu Val Ile Arg Phe Thr Asp 
    210                 215                 220                 


Ala Gly Arg Arg Val Thr Ser Trp Thr Thr Gly His Tyr Trp Gly Leu 
225                 230                 235                 240 


Arg Leu Tyr Val Ser Gly Gln Asp Pro Gly Leu Thr Phe Gly Ile Arg 
                245                 250                 255     


Leu Arg Tyr Gln Asn Leu Gly Pro Arg Val Pro Ile Gly Pro Asn Pro 
            260                 265                 270         


Val Leu Ala Asp Gln Gln Pro Leu Ser Lys Pro Lys Pro Val Lys Ser 
        275                 280                 285             


Pro Ser Val Thr Lys Pro Pro Ser Gly Thr Pro Leu Ser Pro Thr Gln 
    290                 295                 300                 


Leu Pro Pro Ala Gly Thr Glu Asn Arg Leu Leu Asn Leu Val Asp Gly 
305                 310                 315                 320 


Ala Tyr Gln Ala Leu Asn Leu Thr Ser Pro Asp Lys Thr Gln Glu Cys 
                325                 330                 335     


Trp Leu Cys Leu Val Ala Gly Pro Pro Tyr Tyr Glu Gly Val Ala Val 
            340                 345                 350         


Leu Gly Thr Tyr Ser Asn His Thr Ser Ala Pro Ala Asn Cys Ser Val 
        355                 360                 365             


Ala Ser Gln His Lys Leu Thr Leu Ser Glu Val Thr Gly Gln Gly Leu 
    370                 375                 380                 


Cys Ile Gly Ala Val Pro Lys Thr His Gln Ala Leu Cys Asn Thr Thr 
385                 390                 395                 400 


Gln Thr Ser Ser Arg Gly Ser Tyr Tyr Leu Val Ala Pro Thr Gly Thr 
                405                 410                 415     


Met Trp Ala Cys Ser Thr Gly Leu Thr Pro Cys Ile Ser Thr Thr Ile 
            420                 425                 430         


Leu Asn Leu Thr Thr Asp Tyr Cys Val Leu Val Glu Leu Trp Pro Arg 
        435                 440                 445             


Val Thr Tyr His Ser Pro Ser Tyr Val Tyr Gly Leu Phe Glu Arg Ser 
    450                 455                 460                 


Asn Arg His Lys Arg Glu Pro Val Ser Leu Thr Leu Ala Leu Leu Leu 
465                 470                 475                 480 


Gly Gly Leu Thr Met Gly Gly Ile Ala Ala Gly Ile Gly Thr Gly Thr 
                485                 490                 495     


Thr Ala Leu Met Ala Thr Gln Gln Phe Gln Gln Leu Gln Ala Ala Val 
            500                 505                 510         


Gln Asp Asp Leu Arg Glu Val Glu Lys Ser Ile Ser Asn Leu Glu Lys 
        515                 520                 525             


Ser Leu Thr Ser Leu Ser Glu Val Val Leu Gln Asn Arg Arg Gly Leu 
    530                 535                 540                 


Asp Leu Leu Phe Leu Lys Glu Gly Gly Leu Cys Ala Ala Leu Lys Glu 
545                 550                 555                 560 


Glu Cys Cys Phe Tyr Ala Asp His Thr Gly Leu Val Arg Asp Ser Met 
                565                 570                 575     


Ala Lys Leu Arg Glu Arg Leu Asn Gln Arg Gln Lys Leu Phe Glu Ser 
            580                 585                 590         


Thr Gln Gly Trp Phe Glu Gly Leu Phe Asn Arg Ser Pro Trp Phe Thr 
        595                 600                 605             


Thr Leu Ile Ser Thr Ile Met Gly Pro Leu Ile Val Leu Leu Met Ile 
    610                 615                 620                 


Leu Leu Phe Gly Pro Cys Ile Leu Asn Arg Leu Val Gln Phe Val Lys 
625                 630                 635                 640 


Asp Arg Ile Ser Val Val Gln Ala Leu Val Leu Thr Gln Gln Tyr His 
                645                 650                 655     


Gln Leu Lys Pro Ile Glu Tyr Glu Pro 
            660                 665 


<210>  5
<211>  35
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Forward Primer puroR

<400>  5
ataacccggg atgaccgagt acaagcccac ggtgc                                  35


<210>  6
<211>  32
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Reverse Primer puroR

<400>  6
attatctaga tcaggcaccg ggcttgcggg tc                                     32


<210>  7
<211>  600
<212>  DNA
<213>  Streptomyces alboniger

<220>
<223>  Puromycin resistance gene

<400>  7
atgaccgagt acaagcccac ggtgcgcctc gccacccgcg acgacgtccc cagggccgta       60

cgcaccctcg ccgccgcgtt cgccgactac cccgccacgc gccacaccgt cgatccggac      120

cgccacatcg agcgggtcac cgagctgcaa gaactcttcc tcacgcgcgt cgggctcgac      180

atcggcaagg tgtgggtcgc ggacgacggc gccgcggtgg cggtctggac cacgccggag      240

agcgtcgaag cgggggcggt gttcgccgag atcggcccgc gcatggccga gttgagcggt      300

tcccggctgg ccgcgcagca acagatggaa ggcctcctgg cgccgcaccg gcccaaggag      360

cccgcgtggt tcctggccac cgtcggcgtc tcgcccgacc accagggcaa gggtctgggc      420

agcgccgtcg tgctccccgg agtggaggcg gccgagcgcg ccggggtgcc cgccttcctg      480

gagacctccg cgccccgcaa cctccccttc tacgagcggc tcggcttcac cgtcaccgcc      540

gacgtcgagg tgcccgaagg accgcgcacc tggtgcatga cccgcaagcc cggtgcctga      600


<210>  8
<211>  199
<212>  PRT
<213>  Streptomyces alboniger

<220>
<223>  Puromycin resistance gene

<400>  8

Met Thr Glu Tyr Lys Pro Thr Val Arg Leu Ala Thr Arg Asp Asp Val 
1               5                   10                  15      


Pro Arg Ala Val Arg Thr Leu Ala Ala Ala Phe Ala Asp Tyr Pro Ala 
            20                  25                  30          


Thr Arg His Thr Val Asp Pro Asp Arg His Ile Glu Arg Val Thr Glu 
        35                  40                  45              


Leu Gln Glu Leu Phe Leu Thr Arg Val Gly Leu Asp Ile Gly Lys Val 
    50                  55                  60                  


Trp Val Ala Asp Asp Gly Ala Ala Val Ala Val Trp Thr Thr Pro Glu 
65                  70                  75                  80  


Ser Val Glu Ala Gly Ala Val Phe Ala Glu Ile Gly Pro Arg Met Ala 
                85                  90                  95      


Glu Leu Ser Gly Ser Arg Leu Ala Ala Gln Gln Gln Met Glu Gly Leu 
            100                 105                 110         


Leu Ala Pro His Arg Pro Lys Glu Pro Ala Trp Phe Leu Ala Thr Val 
        115                 120                 125             


Gly Val Ser Pro Asp His Gln Gly Lys Gly Leu Gly Ser Ala Val Val 
    130                 135                 140                 


Leu Pro Gly Val Glu Ala Ala Glu Arg Ala Gly Val Pro Ala Phe Leu 
145                 150                 155                 160 


Glu Thr Ser Ala Pro Arg Asn Leu Pro Phe Tyr Glu Arg Leu Gly Phe 
                165                 170                 175     


Thr Val Thr Ala Asp Val Glu Val Pro Glu Gly Pro Arg Thr Trp Cys 
            180                 185                 190         


Met Thr Arg Lys Pro Gly Ala 
        195                 


<210>  9
<211>  47
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Forward Primer hygroR

<400>  9
aattaatcat gacccgggac catgaaaaag cctgaactca ccgcgac                     47


<210>  10
<211>  51
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Reverse Primer hygroR

<400>  10
aattaagtcg acgcggccgc tctagactat tcctttgccc tcggacgagt g                51


<210>  11
<211>  1026
<212>  DNA
<213>  Streptomyces hygroscopicus

<220>
<223>  Hygromycin resistance gene

<400>  11
atgaaaaagc ctgaactcac cgcgacgtct gtcgagaagt ttctgatcga aaagttcgac       60

agcgtctccg acctgatgca gctctcggag ggcgaagaat ctcgtgcttt cagcttcgat      120

gtaggagggc gtggatatgt cctgcgggta aatagctgcg ccgatggttt ctacaaagat      180

cgttatgttt atcggcactt tgcatcggcc gcgctcccga ttccggaagt gcttgacatt      240

ggggaattca gcgagagcct gacctattgc atctcccgcc gtgcacaggg tgtcacgttg      300

caagacctgc ctgaaaccga actgcccgct gttctgcagc cggtcgcgga ggccatggat      360

gcgatcgctg cggccgatct tagccagacg agcgggttcg gcccattcgg accgcaagga      420

atcggtcaat acactacatg gcgtgatttc atatgcgcga ttgctgatcc ccatgtgtat      480

cactggcaaa ctgtgatgga cgacaccgtc agtgcgtccg tcgcgcaggc tctcgatgag      540

ctgatgcttt gggccgagga ctgccccgaa gtccggcacc tcgtgcacgc ggatttcggc      600

tccaacaatg tcctgacgga caatggccgc ataacagcgg tcattgactg gagcgaggcg      660

atgttcgggg attcccaata cgaggtcgcc aacatcttct tctggaggcc gtggttggct      720

tgtatggagc agcagacgcg ctacttcgag cggaggcatc cggagcttgc aggatcgccg      780

cggctccggg cgtatatgct ccgcattggt cttgaccaac tctatcagag cttggttgac      840

ggcaatttcg atgatgcagc ttgggcgcag ggtcgatgcg acgcaatcgt ccgatccgga      900

gccgggactg tcgggcgtac acaaatcgcc cgcagaagcg cggccgtctg gaccgatggc      960

tgtgtagaag tactcgccga tagtggaaac cgacgcccca gcactcgtcc gagggcaaag     1020

gaatag                                                                1026


<210>  12
<211>  341
<212>  PRT
<213>  Streptomyces hygroscopicus

<220>
<223>  Hygromycin resistance gene

<400>  12

Met Lys Lys Pro Glu Leu Thr Ala Thr Ser Val Glu Lys Phe Leu Ile 
1               5                   10                  15      


Glu Lys Phe Asp Ser Val Ser Asp Leu Met Gln Leu Ser Glu Gly Glu 
            20                  25                  30          


Glu Ser Arg Ala Phe Ser Phe Asp Val Gly Gly Arg Gly Tyr Val Leu 
        35                  40                  45              


Arg Val Asn Ser Cys Ala Asp Gly Phe Tyr Lys Asp Arg Tyr Val Tyr 
    50                  55                  60                  


Arg His Phe Ala Ser Ala Ala Leu Pro Ile Pro Glu Val Leu Asp Ile 
65                  70                  75                  80  


Gly Glu Phe Ser Glu Ser Leu Thr Tyr Cys Ile Ser Arg Arg Ala Gln 
                85                  90                  95      


Gly Val Thr Leu Gln Asp Leu Pro Glu Thr Glu Leu Pro Ala Val Leu 
            100                 105                 110         


Gln Pro Val Ala Glu Ala Met Asp Ala Ile Ala Ala Ala Asp Leu Ser 
        115                 120                 125             


Gln Thr Ser Gly Phe Gly Pro Phe Gly Pro Gln Gly Ile Gly Gln Tyr 
    130                 135                 140                 


Thr Thr Trp Arg Asp Phe Ile Cys Ala Ile Ala Asp Pro His Val Tyr 
145                 150                 155                 160 


His Trp Gln Thr Val Met Asp Asp Thr Val Ser Ala Ser Val Ala Gln 
                165                 170                 175     


Ala Leu Asp Glu Leu Met Leu Trp Ala Glu Asp Cys Pro Glu Val Arg 
            180                 185                 190         


His Leu Val His Ala Asp Phe Gly Ser Asn Asn Val Leu Thr Asp Asn 
        195                 200                 205             


Gly Arg Ile Thr Ala Val Ile Asp Trp Ser Glu Ala Met Phe Gly Asp 
    210                 215                 220                 


Ser Gln Tyr Glu Val Ala Asn Ile Phe Phe Trp Arg Pro Trp Leu Ala 
225                 230                 235                 240 


Cys Met Glu Gln Gln Thr Arg Tyr Phe Glu Arg Arg His Pro Glu Leu 
                245                 250                 255     


Ala Gly Ser Pro Arg Leu Arg Ala Tyr Met Leu Arg Ile Gly Leu Asp 
            260                 265                 270         


Gln Leu Tyr Gln Ser Leu Val Asp Gly Asn Phe Asp Asp Ala Ala Trp 
        275                 280                 285             


Ala Gln Gly Arg Cys Asp Ala Ile Val Arg Ser Gly Ala Gly Thr Val 
    290                 295                 300                 


Gly Arg Thr Gln Ile Ala Arg Arg Ser Ala Ala Val Trp Thr Asp Gly 
305                 310                 315                 320 


Cys Val Glu Val Leu Ala Asp Ser Gly Asn Arg Arg Pro Ser Thr Arg 
                325                 330                 335     


Pro Arg Ala Lys Glu 
            340     


<210>  13
<211>  49
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Forward Primer bsr

<400>  13
aattaacccg ggaccatgaa aacatttaac atttctcaac aagatctag                   49


<210>  14
<211>  42
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Reverse Primer bsr

<400>  14
aattaaacta gtttaatttc gggtatattt gagtggaatg ag                          42


<210>  15
<211>  423
<212>  DNA
<213>  Bacillus cereus

<220>
<223>  Blasticidin resistance gene

<400>  15
atgaaaacat ttaacatttc tcaacaagat ctagaattag tagaagtagc gacagagaag       60

attacaatgc tttatgagga taataaacat catgtgggag cggcaattcg tacgaaaaca      120

ggagaaatca tttcggcagt acatattgaa gcgtatatag gacgagtaac tgtttgtgca      180

gaagccattg cgattggtag tgcagtttcg aatggacaaa aggattttga cacgattgta      240

gctgttagac acccttattc tgacgaagta gatagaagta ttcgagtggt aagtccttgt      300

ggtatgtgta gggagttgat ttcagactat gcaccagatt gttttgtgtt aatagaaatg      360

aatggcaagt tagtcaaaac tacgattgaa gaactcattc cactcaaata tacccgaaat      420

taa                                                                    423


<210>  16
<211>  140
<212>  PRT
<213>  Bacillus cereus

<220>
<223>  Blasticidin resistance gene

<400>  16
Met Lys Thr Phe Asn Ile Ser Gln Gln Asp Leu Glu Leu Val Glu Val 
1               5                   10                  15      


Ala Thr Glu Lys Ile Thr Met Leu Tyr Glu Asp Asn Lys His His Val 
            20                  25                  30          


Gly Ala Ala Ile Arg Thr Lys Thr Gly Glu Ile Ile Ser Ala Val His 
        35                  40                  45              


Ile Glu Ala Tyr Ile Gly Arg Val Thr Val Cys Ala Glu Ala Ile Ala 
    50                  55                  60                  


Ile Gly Ser Ala Val Ser Asn Gly Gln Lys Asp Phe Asp Thr Ile Val 
65                  70                  75                  80  


Ala Val Arg His Pro Tyr Ser Asp Glu Val Asp Arg Ser Ile Arg Val 
                85                  90                  95      


Val Ser Pro Cys Gly Met Cys Arg Glu Leu Ile Ser Asp Tyr Ala Pro 
            100                 105                 110         


Asp Cys Phe Val Leu Ile Glu Met Asn Gly Lys Leu Val Lys Thr Thr 
        115                 120                 125             


Ile Glu Glu Leu Ile Pro Leu Lys Tyr Thr Arg Asn 
    130                 135                 140 


<210>  17
<211>  375
<212>  DNA
<213>  Staphylococcus aureus

<220>
<223>  Bleomycin resistance gene

<400>  17
atggccaagt tgaccagtgc cgttccggtg ctcaccgcgc gcgacgtcgc cggagcggtc       60

gagttctgga ccgaccggct cgggttctcc cgggacttcg tggaggacga cttcgccggt      120

gtggtccggg acgacgtgac cctgttcatc agcgcggtcc aggaccaggt ggtgccggac      180

aacaccctgg cctgggtgtg ggtgcgcggc ctggacgagc tgtacgccga gtggtcggag      240

gtcgtgtcca cgaacttccg ggacgcctcc gggccggcca tgaccgagat cggcgagcag      300

ccgtgggggc gggagttcgc cctgcgcgac ccggccggca actgcgtgca cttcgtggcc      360

gaggagcagg actga                                                       375


<210>  18
<211>  124
<212>  PRT
<213>  Staphylococcus aureus

<220>
<223>  Bleomycin resistance gene

<400>  18

Met Ala Lys Leu Thr Ser Ala Val Pro Val Leu Thr Ala Arg Asp Val 
1               5                   10                  15      


Ala Gly Ala Val Glu Phe Trp Thr Asp Arg Leu Gly Phe Ser Arg Asp 
            20                  25                  30          


Phe Val Glu Asp Asp Phe Ala Gly Val Val Arg Asp Asp Val Thr Leu 
        35                  40                  45              


Phe Ile Ser Ala Val Gln Asp Gln Val Val Pro Asp Asn Thr Leu Ala 
    50                  55                  60                  


Trp Val Trp Val Arg Gly Leu Asp Glu Leu Tyr Ala Glu Trp Ser Glu 
65                  70                  75                  80  


Val Val Ser Thr Asn Phe Arg Asp Ala Ser Gly Pro Ala Met Thr Glu 
                85                  90                  95      


Ile Gly Glu Gln Pro Trp Gly Arg Glu Phe Ala Leu Arg Asp Pro Ala 
            100                 105                 110         


Gly Asn Cys Val His Phe Val Ala Glu Glu Gln Asp 
        115                 120                 


<210>  19
<211>  804
<212>  DNA
<213>  Escherichia coli

<220>
<223>  Neomycin resistance gene

<400>  19
atgggatcgg ccattgaaca agatggattg cacgcaggtt ctccggccgc ttgggtggag       60

aggctattcg gctatgactg ggcacaacag acaatcggct gctctgatgc cgccgtgttc      120

cggctgtcag cgcaggggcg cccggttctt tttgtcaaga ccgacctgtc cggtgccctg      180

aatgaactgc aggacgaggc agcgcggcta tcgtggctgg ccacgacggg cgttccttgc      240

gcagctgtgc tcgacgttgt cactgaagcg ggaagggact ggctgctatt gggcgaagtg      300

ccggggcagg atctcctgtc atctcacctt gctcctgccg agaaagtatc catcatggct      360

gatgcaatgc ggcggctgca tacgcttgat ccggctacct gcccattcga ccaccaagcg      420

aaacatcgca tcgagcgagc acgtactcgg atggaagccg gtcttgtcga tcaggatgat      480

ctggacgaag agcatcaggg gctcgcgcca gccgaactgt tcgccaggct caaggcgcgc      540

atgcccgacg gcgatgatct cgtcgtgacc catggcgatg cctgcttgcc gaatatcatg      600

gtggaaaatg gccgcttttc tggattcatc gactgtggcc ggctgggtgt ggcggaccgc      660

tatcaggaca tagcgttggc tacccgtgat attgctgaag agcttggcgg cgaatgggct      720

gaccgcttcc tcgtgcttta cggtatcgcc gctcccgatt cgcagcgcat cgccttctat      780

cgccttcttg acgagttctt ctga                                             804


<210>  20
<211>  267
<212>  PRT
<213>  Escherichia coli

<220>
<223>  Neomycin resistance gene

<400>  20

Met Gly Ser Ala Ile Glu Gln Asp Gly Leu His Ala Gly Ser Pro Ala 
1               5                   10                  15      


Ala Trp Val Glu Arg Leu Phe Gly Tyr Asp Trp Ala Gln Gln Thr Ile 
            20                  25                  30          


Gly Cys Ser Asp Ala Ala Val Phe Arg Leu Ser Ala Gln Gly Arg Pro 
        35                  40                  45              


Val Leu Phe Val Lys Thr Asp Leu Ser Gly Ala Leu Asn Glu Leu Gln 
    50                  55                  60                  


Asp Glu Ala Ala Arg Leu Ser Trp Leu Ala Thr Thr Gly Val Pro Cys 
65                  70                  75                  80  


Ala Ala Val Leu Asp Val Val Thr Glu Ala Gly Arg Asp Trp Leu Leu 
                85                  90                  95      


Leu Gly Glu Val Pro Gly Gln Asp Leu Leu Ser Ser His Leu Ala Pro 
            100                 105                 110         


Ala Glu Lys Val Ser Ile Met Ala Asp Ala Met Arg Arg Leu His Thr 
        115                 120                 125             


Leu Asp Pro Ala Thr Cys Pro Phe Asp His Gln Ala Lys His Arg Ile 
    130                 135                 140                 


Glu Arg Ala Arg Thr Arg Met Glu Ala Gly Leu Val Asp Gln Asp Asp 
145                 150                 155                 160 


Leu Asp Glu Glu His Gln Gly Leu Ala Pro Ala Glu Leu Phe Ala Arg 
                165                 170                 175     


Leu Lys Ala Arg Met Pro Asp Gly Asp Asp Leu Val Val Thr His Gly 
            180                 185                 190         


Asp Ala Cys Leu Pro Asn Ile Met Val Glu Asn Gly Arg Phe Ser Gly 
        195                 200                 205             


Phe Ile Asp Cys Gly Arg Leu Gly Val Ala Asp Arg Tyr Gln Asp Ile 
    210                 215                 220                 


Ala Leu Ala Thr Arg Asp Ile Ala Glu Glu Leu Gly Gly Glu Trp Ala 
225                 230                 235                 240 


Asp Arg Phe Leu Val Leu Tyr Gly Ile Ala Ala Pro Asp Ser Gln Arg 
                245                 250                 255     


Ile Ala Phe Tyr Arg Leu Leu Asp Glu Phe Phe 
            260                 265         


<210>  21
<211>  720
<212>  DNA
<213>  Aequorea victoria

<220>
<223>  Green fluorescent protein

<400>  21
atggtgagca agggcgagga gctgttcacc ggggtggtgc ccatcctggt cgagctggac       60

ggcgacgtaa acggccacaa gttcagcgtg tccggcgagg gcgagggcga tgccacctac      120

ggcaagctga ccctgaagtt catctgcacc accggcaagc tgcccgtgcc ctggcccacc      180

ctcgtgacca ccctgaccta cggcgtgcag tgcttcagcc gctaccccga ccacatgaag      240

cagcacgact tcttcaagtc cgccatgccc gaaggctacg tccaggagcg caccatcttc      300

ttcaaggacg acggcaacta caagacccgc gccgaggtga agttcgaggg cgacaccctg      360

gtgaaccgca tcgagctgaa gggcatcgac ttcaaggagg acggcaacat cctggggcac      420

aagctggagt acaactacaa cagccacaac gtctatatca tggccgacaa gcagaagaac      480

ggcatcaagg tgaacttcaa gatccgccac aacatcgagg acggcagcgt gcagctcgcc      540

gaccactacc agcagaacac ccccatcggc gacggccccg tgctgctgcc cgacaaccac      600

tacctgagca cccagtccgc cctgagcaaa gaccccaacg agaagcgcga tcacatggtc      660

ctgctggagt tcgtgaccgc cgccgggatc actctcggca tggacgagct gtacaagtaa      720


<210>  22
<211>  239
<212>  PRT
<213>  Aequorea victoria

<220>
<223>  Green fluorescent protein

<400>  22

Met Val Ser Lys Gly Glu Glu Leu Phe Thr Gly Val Val Pro Ile Leu 
1               5                   10                  15      


Val Glu Leu Asp Gly Asp Val Asn Gly His Lys Phe Ser Val Ser Gly 
            20                  25                  30          


Glu Gly Glu Gly Asp Ala Thr Tyr Gly Lys Leu Thr Leu Lys Phe Ile 
        35                  40                  45              


Cys Thr Thr Gly Lys Leu Pro Val Pro Trp Pro Thr Leu Val Thr Thr 
    50                  55                  60                  


Leu Thr Tyr Gly Val Gln Cys Phe Ser Arg Tyr Pro Asp His Met Lys 
65                  70                  75                  80  


Gln His Asp Phe Phe Lys Ser Ala Met Pro Glu Gly Tyr Val Gln Glu 
                85                  90                  95      


Arg Thr Ile Phe Phe Lys Asp Asp Gly Asn Tyr Lys Thr Arg Ala Glu 
            100                 105                 110         


Val Lys Phe Glu Gly Asp Thr Leu Val Asn Arg Ile Glu Leu Lys Gly 
        115                 120                 125             


Ile Asp Phe Lys Glu Asp Gly Asn Ile Leu Gly His Lys Leu Glu Tyr 
    130                 135                 140                 


Asn Tyr Asn Ser His Asn Val Tyr Ile Met Ala Asp Lys Gln Lys Asn 
145                 150                 155                 160 


Gly Ile Lys Val Asn Phe Lys Ile Arg His Asn Ile Glu Asp Gly Ser 
                165                 170                 175     


Val Gln Leu Ala Asp His Tyr Gln Gln Asn Thr Pro Ile Gly Asp Gly 
            180                 185                 190         


Pro Val Leu Leu Pro Asp Asn His Tyr Leu Ser Thr Gln Ser Ala Leu 
        195                 200                 205             


Ser Lys Asp Pro Asn Glu Lys Arg Asp His Met Val Leu Leu Glu Phe 
    210                 215                 220                 


Val Thr Ala Ala Gly Ile Thr Leu Gly Met Asp Glu Leu Tyr Lys 
225                 230                 235                 


<210>  23
<211>  720
<212>  DNA
<213>  Aequorea victoria

<220>
<223>  Yellow fluorescent protein

<400>  23
atggtgagca agggcgagga gctgttcacc ggggtggtgc ccatcctggt cgagctggac       60

ggcgacgtaa acggccacaa gttcagcgtg tccggcgagg gcgagggcga tgccacctac      120

ggcaagctga ccctgaagtt catctgcacc accggcaagc tgcccgtgcc ctggcccacc      180

ctcgtgacca ccttcggcta cggcctgcag tgcttcgccc gctaccccga ccacatgaag      240

cagcacgact tcttcaagtc cgccatgccc gaaggctacg tccaggagcg caccatcttc      300

ttcaaggacg acggcaacta caagacccgc gccgaggtga agttcgaggg cgacaccctg      360

gtgaaccgca tcgagctgaa gggcatcgac ttcaaggagg acggcaacat cctggggcac      420

aagctggagt acaactacaa cagccacaac gtctatatca tggccgacaa gcagaagaac      480

ggcatcaagg tgaacttcaa gatccgccac aacatcgagg acggcagcgt gcagctcgcc      540

gaccactacc agcagaacac ccccatcggc gacggccccg tgctgctgcc cgacaaccac      600

tacctgagct accagtccgc cctgagcaaa gaccccaacg agaagcgcga tcacatggtc      660

ctgctggagt tcgtgaccgc cgccgggatc actctcggca tggacgagct gtacaagtag      720


<210>  24
<211>  239
<212>  PRT
<213>  Aequorea victoria

<220>
<223>  Yellow fluorescent protein

<400>  24

Met Val Ser Lys Gly Glu Glu Leu Phe Thr Gly Val Val Pro Ile Leu 
1               5                   10                  15      


Val Glu Leu Asp Gly Asp Val Asn Gly His Lys Phe Ser Val Ser Gly 
            20                  25                  30          


Glu Gly Glu Gly Asp Ala Thr Tyr Gly Lys Leu Thr Leu Lys Phe Ile 
        35                  40                  45              


Cys Thr Thr Gly Lys Leu Pro Val Pro Trp Pro Thr Leu Val Thr Thr 
    50                  55                  60                  


Phe Gly Tyr Gly Leu Gln Cys Phe Ala Arg Tyr Pro Asp His Met Lys 
65                  70                  75                  80  


Gln His Asp Phe Phe Lys Ser Ala Met Pro Glu Gly Tyr Val Gln Glu 
                85                  90                  95      


Arg Thr Ile Phe Phe Lys Asp Asp Gly Asn Tyr Lys Thr Arg Ala Glu 
            100                 105                 110         


Val Lys Phe Glu Gly Asp Thr Leu Val Asn Arg Ile Glu Leu Lys Gly 
        115                 120                 125             


Ile Asp Phe Lys Glu Asp Gly Asn Ile Leu Gly His Lys Leu Glu Tyr 
    130                 135                 140                 


Asn Tyr Asn Ser His Asn Val Tyr Ile Met Ala Asp Lys Gln Lys Asn 
145                 150                 155                 160 


Gly Ile Lys Val Asn Phe Lys Ile Arg His Asn Ile Glu Asp Gly Ser 
                165                 170                 175     


Val Gln Leu Ala Asp His Tyr Gln Gln Asn Thr Pro Ile Gly Asp Gly 
            180                 185                 190         


Pro Val Leu Leu Pro Asp Asn His Tyr Leu Ser Tyr Gln Ser Ala Leu 
        195                 200                 205             


Ser Lys Asp Pro Asn Glu Lys Arg Asp His Met Val Leu Leu Glu Phe 
    210                 215                 220                 


Val Thr Ala Ala Gly Ile Thr Leu Gly Met Asp Glu Leu Tyr Lys 
225                 230                 235                 


<210>  25
<211>  948
<212>  DNA
<213>  Homo sapiens

<220>
<223>  Truncated NGFR

<400>  25
atgggggcag gtgccaccgg ccgcgccatg gacgggccgc gcctgctgct gttgctgctt       60

ctgggggtgt cccttggagg tgccaaggag gcatgcccca caggcctgta cacacatggc      120

ggcgagtgct gcaaagcctg caacctgggc gaaggtgtgg cccagccttg tggagccaac      180

cagaccgtgt gtgagccctg cctggacagt gtgacgttct ccgacgtggt gagcgcgacg      240

gagccgtgca agccgtgcac tgagtgcgtg gggcttcaga gcatgtcggc gccgtgcgtg      300

gaggccgacg acgccgtgtg ccgctgtgcc tacggctact accaggacga gacgaccggg      360

cgctgcgagg cgtgccgcgt gtgcgaggcg ggctcgggcc tcgtattctc gtgccaggac      420

aagcagaaca ccgtgtgcga ggagtgcccc gacggcacgt attcagatga ggccaaccat      480

gtggacccgt gcctgccctg caccgtgtgc gaggacaccg agcgccagct gcgcgagtgc      540

acacgctggg ccgacgccga gtgcgaggag atccctggcc gttggattac aaggtccaca      600

ccccccgaag gctctgacag cacagccacc agcacccagg agcctgaggc acctccagaa      660

caagacctca tagccagcac ggtggcagat gtggtgacca cagtgatggg cagctcccag      720

cccgtggtaa cccgaggcac caccgacaac ctcatccccg tctattgctc catcctggct      780

gctgtggtgg tgggccttgt ggcctacata gccttcaaga ggtggaacag ctgcaagcag      840

aacaagcaag gagccaacag ccggccagtg aaccagacgc ccccaccaga gggagaaaaa      900

ctccatagtg acagtggcat ctccgtggac agccagagcc tgcaatag                   948


<210>  26
<211>  315
<212>  PRT
<213>  Homo sapiens

<220>
<223>  Truncated NGFR

<400>  26

Met Gly Ala Gly Ala Thr Gly Arg Ala Met Asp Gly Pro Arg Leu Leu 
1               5                   10                  15      


Leu Leu Leu Leu Leu Gly Val Ser Leu Gly Gly Ala Lys Glu Ala Cys 
            20                  25                  30          


Pro Thr Gly Leu Tyr Thr His Gly Gly Glu Cys Cys Lys Ala Cys Asn 
        35                  40                  45              


Leu Gly Glu Gly Val Ala Gln Pro Cys Gly Ala Asn Gln Thr Val Cys 
    50                  55                  60                  


Glu Pro Cys Leu Asp Ser Val Thr Phe Ser Asp Val Val Ser Ala Thr 
65                  70                  75                  80  


Glu Pro Cys Lys Pro Cys Thr Glu Cys Val Gly Leu Gln Ser Met Ser 
                85                  90                  95      


Ala Pro Cys Val Glu Ala Asp Asp Ala Val Cys Arg Cys Ala Tyr Gly 
            100                 105                 110         


Tyr Tyr Gln Asp Glu Thr Thr Gly Arg Cys Glu Ala Cys Arg Val Cys 
        115                 120                 125             


Glu Ala Gly Ser Gly Leu Val Phe Ser Cys Gln Asp Lys Gln Asn Thr 
    130                 135                 140                 


Val Cys Glu Glu Cys Pro Asp Gly Thr Tyr Ser Asp Glu Ala Asn His 
145                 150                 155                 160 


Val Asp Pro Cys Leu Pro Cys Thr Val Cys Glu Asp Thr Glu Arg Gln 
                165                 170                 175     


Leu Arg Glu Cys Thr Arg Trp Ala Asp Ala Glu Cys Glu Glu Ile Pro 
            180                 185                 190         


Gly Arg Trp Ile Thr Arg Ser Thr Pro Pro Glu Gly Ser Asp Ser Thr 
        195                 200                 205             


Ala Thr Ser Thr Gln Glu Pro Glu Ala Pro Pro Glu Gln Asp Leu Ile 
    210                 215                 220                 


Ala Ser Thr Val Ala Asp Val Val Thr Thr Val Met Gly Ser Ser Gln 
225                 230                 235                 240 


Pro Val Val Thr Arg Gly Thr Thr Asp Asn Leu Ile Pro Val Tyr Cys 
                245                 250                 255     


Ser Ile Leu Ala Ala Val Val Val Gly Leu Val Ala Tyr Ile Ala Phe 
            260                 265                 270         


Lys Arg Trp Asn Ser Cys Lys Gln Asn Lys Gln Gly Ala Asn Ser Arg 
        275                 280                 285             


Pro Val Asn Gln Thr Pro Pro Pro Glu Gly Glu Lys Leu His Ser Asp 
    290                 295                 300                 


Ser Gly Ile Ser Val Asp Ser Gln Ser Leu Gln 
305                 310                 315 


<210>  27
<211>  627
<212>  DNA
<213>  Homo sapiens

<220>
<223>  Truncated CD7

<400>  27
atggccgggc ctccgaggct cctgctgctg cccctgcttc tggcgctggc tcgcggcctg       60

cctggggccc tggctgccca agaggtgcag cagtctcccc actgcacgac tgtccccgtg      120

ggagcctccg tcaacatcac ctgctccacc agcgggggcc tgcgtgggat ctacctgagg      180

cagctcgggc cacagcccca agacatcatt tactacgagg acggggtggt gcccactacg      240

gacagacggt tccggggccg catcgacttc tcagggtccc aggacaacct gactatcacc      300

atgcaccgcc tgcagctgtc ggacactggc acctacacct gccaggccat cacggaggtc      360

aatgtctacg gctccggcac cctggtcctg gtgacagagg aacagtccca aggatggcac      420

agatgctcgg acgccccacc aagggcctct gccctccctg ccccaccgac aggctccgcc      480

ctccctgacc cgcagacagc ctctgccctc cctgacccgc cagcagcctc tgccctccct      540

gcggccctgg cggtgatctc cttcctcctc gggctgggcc tgggggtggc gtgtgtgctg      600

gcgaggacac agataaagaa actgtga                                          627


<210>  28
<211>  208
<212>  PRT
<213>  Homo sapiens

<220>
<223>  Truncated CD7

<400>  28

Met Ala Gly Pro Pro Arg Leu Leu Leu Leu Pro Leu Leu Leu Ala Leu 
1               5                   10                  15      


Ala Arg Gly Leu Pro Gly Ala Leu Ala Ala Gln Glu Val Gln Gln Ser 
            20                  25                  30          


Pro His Cys Thr Thr Val Pro Val Gly Ala Ser Val Asn Ile Thr Cys 
        35                  40                  45              


Ser Thr Ser Gly Gly Leu Arg Gly Ile Tyr Leu Arg Gln Leu Gly Pro 
    50                  55                  60                  


Gln Pro Gln Asp Ile Ile Tyr Tyr Glu Asp Gly Val Val Pro Thr Thr 
65                  70                  75                  80  


Asp Arg Arg Phe Arg Gly Arg Ile Asp Phe Ser Gly Ser Gln Asp Asn 
                85                  90                  95      


Leu Thr Ile Thr Met His Arg Leu Gln Leu Ser Asp Thr Gly Thr Tyr 
            100                 105                 110         


Thr Cys Gln Ala Ile Thr Glu Val Asn Val Tyr Gly Ser Gly Thr Leu 
        115                 120                 125             


Val Leu Val Thr Glu Glu Gln Ser Gln Gly Trp His Arg Cys Ser Asp 
    130                 135                 140                 


Ala Pro Pro Arg Ala Ser Ala Leu Pro Ala Pro Pro Thr Gly Ser Ala 
145                 150                 155                 160 


Leu Pro Asp Pro Gln Thr Ala Ser Ala Leu Pro Asp Pro Pro Ala Ala 
                165                 170                 175     


Ser Ala Leu Pro Ala Ala Leu Ala Val Ile Ser Phe Leu Leu Gly Leu 
            180                 185                 190         


Gly Leu Gly Val Ala Cys Val Leu Ala Arg Thr Gln Ile Lys Lys Leu 
        195                 200                 205             


<210>  29
<211>  38
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Forward Primer eMLV-R

<400>  29
tttaagcggc cgcatgggct gcaaaaacct gctcggtc                               38


<210>  30
<211>  38
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Reverse Primer eMLV-R

<400>  30
tttaaggatc ctcatttgca ctggtccaag ttgctgtc                               38


<210>  31
<211>  1869
<212>  DNA
<213>  Mus musculus

<220>
<223>  Rec1 receptor nucleic acid

<400>  31
atgggctgca aaaacctgct cggtctgggc cagcagatgc tgcgccggaa ggtggtggac       60

tgcagccggg aggagagccg gctgtcccgc tgcctcaaca cctatgacct ggtagctctt      120

ggggtgggca gcaccttggg cgctggtgtc tatgtcctag ccggtgccgt ggcccgtgaa      180

aatgctggcc ctgccatcgt catctccttc ttgattgctg ctctcgcctc cgtgctggcc      240

ggcctgtgct acggcgagtt tggtgcccgt gtccccaaga cgggctcagc ctacctctac      300

agctacgtga cggtggggga gctttgggcc ttcatcactg gctggaacct gattctctcc      360

tacatcatcg gtacttcaag cgtggcaaga gcctggagtg cgacttttga cgagctgata      420

ggcaagccca tcggagagtt ctcacgtcag cacatggccc tgaatgctcc tggggtgctg      480

gcccaaaccc cggacatatt tgctgtgatt ataattatca tcttaacagg actgttaact      540

cttggcgtga aggagtcagc catggtcaac aaaattttca cctgtatcaa tgtcctggtc      600

ttgtgcttca tcgtggtgtc cgggttcgtg aaaggctcca ttaaaaactg gcagctcacg      660

gagaaaaatt tctcctgtaa caacaacgac acaaacgtga aatacggtga gggagggttt      720

atgccctttg gattctctgg tgtcctgtca ggggcagcga cctgctttta tgccttcgtg      780

ggctttgact gcatcgccac cacaggggaa gaagtcaaga acccccagaa ggccattcct      840

gtgggcatcg tggcgtccct cctcatttgc ttcatagcgt actttggcgt gtccgccgct      900

ctcacgctca tgatgcctta cttctgcctg gacatcgaca gcccgctgcc tggtgccttc      960

aagcaccagg gctgggaaga agctaagtac gcagtggcca ttggctctct ctgcgcactt     1020

tccaccagtc tcctaggctc catgtttccc atgccccgag ttatctatgc catggctgaa     1080

gatggactac tgtttaaatt tttggccaaa atcaacaata ggaccaaaac acccgtaatc     1140

gccactgtga cctcaggcgc cattgctgct gtgatggcct tcctctttga actgaaggac     1200

ctggtggacc tcatgtccat tggcactctc ctggcttact ctttggtggc tgcctgtgtt     1260

ttggtcttac ggtaccagcc agaacaacct aatctggtat accagatggc cagaaccacc     1320

gaggagctag atcgagtaga tcagaatgag ctggtcagtg ccagtgaatc acagacaggc     1380

tttttaccgg tagccgagaa gttttctctg aaatccatcc tctcacccaa gaacgtggag     1440

ccctccaaat tctcagggct aattgtgaac atttcagccg gcctcctagc cgctcttatc     1500

atcaccgtgt gcattgtggc cgtgcttgga agagaggccc tggccgaagg gacactgtgg     1560

gcagtctttg taatgacagg gtcagtcctc ctctgcatgc tggtgacagg catcatctgg     1620

agacagcctg agagcaagac caagctctca tttaaggtac cctttgtccc cgtacttcct     1680

gtcttgagca tcttcgtgaa catctatctc atgatgcagc tggaccaggg cacgtgggtc     1740

cggtttgcag tgtggatgct gataggtttc accatctatt tcggttatgg gatctggcac     1800

agtgaggaag cgtccctggc tgctggccag gcaaagactc ctgacagcaa cttggaccag     1860

tgcaaatga                                                             1869


<210>  32
<211>  622
<212>  PRT
<213>  Mus musculus

<220>
<223>  Rec1 receptor amino acid

<400>  32

Met Gly Cys Lys Asn Leu Leu Gly Leu Gly Gln Gln Met Leu Arg Arg 
1               5                   10                  15      


Lys Val Val Asp Cys Ser Arg Glu Glu Ser Arg Leu Ser Arg Cys Leu 
            20                  25                  30          


Asn Thr Tyr Asp Leu Val Ala Leu Gly Val Gly Ser Thr Leu Gly Ala 
        35                  40                  45              


Gly Val Tyr Val Leu Ala Gly Ala Val Ala Arg Glu Asn Ala Gly Pro 
    50                  55                  60                  


Ala Ile Val Ile Ser Phe Leu Ile Ala Ala Leu Ala Ser Val Leu Ala 
65                  70                  75                  80  


Gly Leu Cys Tyr Gly Glu Phe Gly Ala Arg Val Pro Lys Thr Gly Ser 
                85                  90                  95      


Ala Tyr Leu Tyr Ser Tyr Val Thr Val Gly Glu Leu Trp Ala Phe Ile 
            100                 105                 110         


Thr Gly Trp Asn Leu Ile Leu Ser Tyr Ile Ile Gly Thr Ser Ser Val 
        115                 120                 125             


Ala Arg Ala Trp Ser Ala Thr Phe Asp Glu Leu Ile Gly Lys Pro Ile 
    130                 135                 140                 


Gly Glu Phe Ser Arg Gln His Met Ala Leu Asn Ala Pro Gly Val Leu 
145                 150                 155                 160 


Ala Gln Thr Pro Asp Ile Phe Ala Val Ile Ile Ile Ile Ile Leu Thr 
                165                 170                 175     


Gly Leu Leu Thr Leu Gly Val Lys Glu Ser Ala Met Val Asn Lys Ile 
            180                 185                 190         


Phe Thr Cys Ile Asn Val Leu Val Leu Cys Phe Ile Val Val Ser Gly 
        195                 200                 205             


Phe Val Lys Gly Ser Ile Lys Asn Trp Gln Leu Thr Glu Lys Asn Phe 
    210                 215                 220                 


Ser Cys Asn Asn Asn Asp Thr Asn Val Lys Tyr Gly Glu Gly Gly Phe 
225                 230                 235                 240 


Met Pro Phe Gly Phe Ser Gly Val Leu Ser Gly Ala Ala Thr Cys Phe 
                245                 250                 255     


Tyr Ala Phe Val Gly Phe Asp Cys Ile Ala Thr Thr Gly Glu Glu Val 
            260                 265                 270         


Lys Asn Pro Gln Lys Ala Ile Pro Val Gly Ile Val Ala Ser Leu Leu 
        275                 280                 285             


Ile Cys Phe Ile Ala Tyr Phe Gly Val Ser Ala Ala Leu Thr Leu Met 
    290                 295                 300                 


Met Pro Tyr Phe Cys Leu Asp Ile Asp Ser Pro Leu Pro Gly Ala Phe 
305                 310                 315                 320 


Lys His Gln Gly Trp Glu Glu Ala Lys Tyr Ala Val Ala Ile Gly Ser 
                325                 330                 335     


Leu Cys Ala Leu Ser Thr Ser Leu Leu Gly Ser Met Phe Pro Met Pro 
            340                 345                 350         


Arg Val Ile Tyr Ala Met Ala Glu Asp Gly Leu Leu Phe Lys Phe Leu 
        355                 360                 365             


Ala Lys Ile Asn Asn Arg Thr Lys Thr Pro Val Ile Ala Thr Val Thr 
    370                 375                 380                 


Ser Gly Ala Ile Ala Ala Val Met Ala Phe Leu Phe Glu Leu Lys Asp 
385                 390                 395                 400 


Leu Val Asp Leu Met Ser Ile Gly Thr Leu Leu Ala Tyr Ser Leu Val 
                405                 410                 415     


Ala Ala Cys Val Leu Val Leu Arg Tyr Gln Pro Glu Gln Pro Asn Leu 
            420                 425                 430         


Val Tyr Gln Met Ala Arg Thr Thr Glu Glu Leu Asp Arg Val Asp Gln 
        435                 440                 445             


Asn Glu Leu Val Ser Ala Ser Glu Ser Gln Thr Gly Phe Leu Pro Val 
    450                 455                 460                 


Ala Glu Lys Phe Ser Leu Lys Ser Ile Leu Ser Pro Lys Asn Val Glu 
465                 470                 475                 480 


Pro Ser Lys Phe Ser Gly Leu Ile Val Asn Ile Ser Ala Gly Leu Leu 
                485                 490                 495     


Ala Ala Leu Ile Ile Thr Val Cys Ile Val Ala Val Leu Gly Arg Glu 
            500                 505                 510         


Ala Leu Ala Glu Gly Thr Leu Trp Ala Val Phe Val Met Thr Gly Ser 
        515                 520                 525             


Val Leu Leu Cys Met Leu Val Thr Gly Ile Ile Trp Arg Gln Pro Glu 
    530                 535                 540                 


Ser Lys Thr Lys Leu Ser Phe Lys Val Pro Phe Val Pro Val Leu Pro 
545                 550                 555                 560 


Val Leu Ser Ile Phe Val Asn Ile Tyr Leu Met Met Gln Leu Asp Gln 
                565                 570                 575     


Gly Thr Trp Val Arg Phe Ala Val Trp Met Leu Ile Gly Phe Thr Ile 
            580                 585                 590         


Tyr Phe Gly Tyr Gly Ile Trp His Ser Glu Glu Ala Ser Leu Ala Ala 
        595                 600                 605             


Gly Gln Ala Lys Thr Pro Asp Ser Asn Leu Asp Gln Cys Lys 
    610                 615                 620         


<210>  33
<211>  10
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Stuffer sequence

<400>  33
ttaattaatt                                                              10


<210>  34
<211>  51
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Forward Primer Kozak Gag/Pol

<400>  34
aataagcggc cgcgccgcca ccatgggcca gactgttacc actcccttaa g                51


<210>  35
<211>  31
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Reverse Primer MLVgp RI

<400>  35
atgaattctt agggggcctc gcgggttaac c                                      31


<210>  36
<211>  5217
<212>  DNA
<213>  Murine leukemia virus

<220>
<223>  MLV gag/pol nucleic acid

<400>  36
atgggccaga ctgttaccac tcccttaagt ttgaccttag gtcactggaa agatgtcgag       60

cggatcgctc acaaccagtc ggtagatgtc aagaagagac gttgggttac cttctgctct      120

gcagaatggc caacctttaa cgtcggatgg ccgcgagacg gcacctttaa ccgagacctc      180

atcacccagg ttaagatcaa ggtcttttca cctggcccgc atggacaccc agaccaggtc      240

ccctacatcg tgacctggga agccttggct tttgaccccc ctccctgggt caagcccttt      300

gtacacccta agcctccgcc tcctcttcct ccatccgccc cgtctctccc ccttgaacct      360

cctcgttcga ccccgcctcg atcctccctt tatccagccc tcactccttc tctaggcgcc      420

aaacctaaac ctcaagttct ttctgacagt ggggggccgc tcatcgacct acttacagaa      480

gaccccccgc cttataggga cccaagacca cccccttccg acagggacgg aaatggtgga      540

gaagcgaccc ctgcgggaga ggcaccggac ccctccccaa tggcatctcg cctacgtggg      600

agacgggagc cccctgtggc cgactccact acctcgcagg cattccccct ccgcgcagga      660

ggaaacggac agcttcaata ctggccgttc tcctcttctg acctttacaa ctggaaaaat      720

aataaccctt ctttttctga agatccaggt aaactgacag ctctgatcga gtctgttctc      780

atcacccatc agcccacctg ggacgactgt cagcagctgt tggggactct gctgaccgga      840

gaagaaaaac aacgggtgct cttagaggct agaaaggcgg tgcggggcga tgatgggcgc      900

cccactcaac tgcccaatga agtcgatgcc gcttttcccc tcgagcgccc agactgggat      960

tacaccaccc aggcaggtag gaaccaccta gtccactatc gccagttgct cctagcgggt     1020

ctccaaaacg cgggcagaag ccccaccaat ttggccaagg taaaaggaat aacacaaggg     1080

cccaatgagt ctccctcggc cttcctagag agacttaagg aagcctatcg caggtacact     1140

ccttatgacc ctgaggaccc agggcaagaa actaatgtgt ctatgtcttt catttggcag     1200

tctgccccag acattgggag aaagttagag aggttagaag atttaaaaaa caagacgctt     1260

ggagatttgg ttagagaggc agaaaagatc tttaataaac gagaaacccc ggaagaaaga     1320

gaggaacgta tcaggagaga aacagaggaa aaagaagaac gccgtaggac agaggatgag     1380

cagaaagaga aagaaagaga tcgtaggaga catagagaga tgagcaagct attggccact     1440

gtcgttagtg gacagaaaca ggatagacag ggaggagaac gaaggaggtc ccaactcgat     1500

cgcgaccagt gtgcctactg caaagaaaag gggcactggg ctaaagattg tcccaagaaa     1560

ccacgaggac ctcggggacc aagaccccag acctccctcc tgaccctaga tgactaggga     1620

ggtcagggtc aggagccccc ccctgaaccc aggataaccc tcaaagtcgg ggggcaaccc     1680

gtcaccttcc tggtagatac tggggcccaa cactccgtgc tgacccaaaa tcctggaccc     1740

ctaagtgata agtctgcctg ggtccaaggg gctactggag gaaagcggta tcgctggacc     1800

acggatcgca aagtacatct agctaccggt aaggtcaccc actctttcct ccatgtacca     1860

gactgtccct atcctctgtt aggaagagat ttgctgacta aactaaaagc ccaaatccac     1920

tttgagggat caggagctca ggttatggga ccaatggggc agcccctgca agtgttgacc     1980

ctaaatatag aagatgagca tcggctacat gagacctcaa aagagccaga tgtttctcta     2040

gggtccacat ggctgtctga ttttcctcag gcctgggcgg aaaccggggg catgggactg     2100

gcagttcgcc aagctcctct gatcatacct ctgaaagcaa cctctacccc cgtgtccata     2160

aaacaatacc ccatgtcaca agaagccaga ctggggatca agccccacat acagagactg     2220

ttggaccagg gaatactggt accctgccag tccccctgga acacgcccct gctacccgtt     2280

aagaaaccag ggactaatga ttataggcct gtccaggatc tgagagaagt caacaagcgg     2340

gtggaagaca tccaccccac cgtgcccaac ccttacaacc tcttgagcgg gctcccaccg     2400

tcccaccagt ggtacactgt gcttgattta aaggatgcct ttttctgcct gagactccac     2460

cccaccagtc agcctctctt cgcctttgag tggagagatc cagagatggg aatctcagga     2520

caattgacct ggaccagact cccacagggt ttcaaaaaca gtcccaccct gtttgatgag     2580

gcactgcaca gagacctagc agacttccgg atccagcacc cagacttgat cctgctacag     2640

tacgtggatg acttactgct ggccgccact tctgagctag actgccaaca aggtactcgg     2700

gccctgttac aaaccctagg gaacctcggg tatcgggcct cggccaagaa agcccaaatt     2760

tgccagaaac aggtcaagta tctggggtat cttctaaaag agggtcagag atggctgact     2820

gaggccagaa aagagactgt gatggggcag cctactccga agacccctcg acaactaagg     2880

gagttcctag ggacggcagg cttctgtcgc ctctggatcc ctgggtttgc agaaatggca     2940

gcccccttgt accctctcac caaaacgggg actctgttta attggggccc agaccaacaa     3000

aaggcctatc aagaaatcaa gcaagctctt ctaactgccc cagccctggg gttgccagat     3060

ttgactaagc cctttgaact ctttgtcgac gagaagcagg gctacgccaa aggtgtccta     3120

acgcaaaaac tgggaccttg gcgtcggccg gtggcctacc tgtccaaaaa gctagaccca     3180

gtagcagctg ggtggccccc ttgcctacgg atggtagcag ccattgccgt actgacaaag     3240

gatgcaggca agctaaccat gggacagcca ctagtcattc tggcccccca tgcagtagag     3300

gcactagtca aacaaccccc cgaccgctgg ctttccaacg cccggatgac tcactatcag     3360

gccttgcttt tggacacgga ccgggtccag ttcggaccgg tggtagccct gaacccggct     3420

acgctgctcc cactgcctga ggaagggctg caacacaact gccttgatat cctggccgaa     3480

gcccacggaa cccgacccga cctaacggac cagccgctcc cagacgccga ccacacctgg     3540

tacacggatg gaagcagtct cttacaagag ggacagcgta aggcgggagc tgcggtgacc     3600

accgagaccg aggtaatctg ggctaaagcc ctgccagccg ggacatccgc tcagcgggct     3660

gaactgatag cactcaccca ggccctaaag atggcagaag gtaagaagct aaatgtttat     3720

actgatagcc gttatgcttt tgctactgcc catatccatg gagaaatata cagaaggcgt     3780

gggttgctca catcagaagg caaagagatc aaaaataaag acgagatctt ggccctacta     3840

aaagccctct ttctgcccaa aagacttagc ataatccatt gtccaggaca tcaaaaggga     3900

cacagcgccg aggctagagg caaccggatg gctgaccaag cggcccgaaa ggcagccatc     3960

acagagactc cagacacctc taccctcctc atagaaaatt catcacccta cacctcagaa     4020

cattttcatt acacagtgac tgatataaag gacctaacca agttgggggc catttatgat     4080

aaaacaaaga agtattgggt ctaccaagga aaacctgtga tgcctgacca gtttactttt     4140

gaattattag actttcttca tcagctgact cacctcagct tctcaaaaat gaaggctctc     4200

ctagagagaa gccacagtcc ctactacatg ctgaaccggg atcgaacact caaaaatatc     4260

actgagacct gcaaagcttg tgcacaagtc aacgccagca agtctgccgt taaacaggga     4320

actagggtcc gcgggcatcg gcccggcact cattgggaga tcgatttcac cgagataaag     4380

cccggattgt atggctataa atatcttcta gtttttatag ataccttttc tggctggata     4440

gaagccttcc caaccaagaa agaaaccgcc aaggtcgtaa ccaagaagct actagaggag     4500

atcttcccca ggttcggcat gcctcaggta ttgggaactg acaatgggcc tgccttcgtc     4560

tccaaggtga gtcagacagt ggccgatctg ttggggattg attggaaatt acattgtgca     4620

tacagacccc aaagctcagg ccaggtagaa agaatgaata gaaccatcaa ggagacttta     4680

actaaattaa cgcttgcaac tggctctaga gactgggtgc tcctactccc cttagccctg     4740

taccgagccc gcaacacgcc gggcccccat ggcctcaccc catatgagat cttatatggg     4800

gcacccccgc cccttgtaaa cttccctgac cctgacatga caagagttac taacagcccc     4860

tctctccaag ctcacttaca ggctctctac ttagtccagc acgaagtctg gagacctctg     4920

gcggcagcct accaagaaca actggaccga ccggtggtac ctcaccctta ccgagtcggc     4980

gacacagtgt gggtccgccg acaccagact aagaacctag aacctcgctg gaaaggacct     5040

tacacagtcc tgctgaccac ccccaccgcc ctcaaagtag acggcatcgc agcttggata     5100

cacgccgccc acgtgaaggc tgccgacccc gggggtggac catcctctag actgacatgg     5160

cgcgttcaac gctctcaaaa ccccttaaaa ataaggttaa cccgcgaggc cccctaa        5217


<210>  37
<211>  1737
<212>  PRT
<213>  Murine leukemia virus

<220>
<223>  MLV gag/pol amino acid

<400>  37

Met Gly Gln Thr Val Thr Thr Pro Leu Ser Leu Thr Leu Gly His Trp 
1               5                   10                  15      


Lys Asp Val Glu Arg Ile Ala His Asn Gln Ser Val Asp Val Lys Lys 
            20                  25                  30          


Arg Arg Trp Val Thr Phe Cys Ser Ala Glu Trp Pro Thr Phe Asn Val 
        35                  40                  45              


Gly Trp Pro Arg Asp Gly Thr Phe Asn Arg Asp Leu Ile Thr Gln Val 
    50                  55                  60                  


Lys Ile Lys Val Phe Ser Pro Gly Pro His Gly His Pro Asp Gln Val 
65                  70                  75                  80  


Pro Tyr Ile Val Thr Trp Glu Ala Leu Ala Phe Asp Pro Pro Pro Trp 
                85                  90                  95      


Val Lys Pro Phe Val His Pro Lys Pro Pro Pro Pro Leu Pro Pro Ser 
            100                 105                 110         


Ala Pro Ser Leu Pro Leu Glu Pro Pro Arg Ser Thr Pro Pro Arg Ser 
        115                 120                 125             


Ser Leu Tyr Pro Ala Leu Thr Pro Ser Leu Gly Ala Lys Pro Lys Pro 
    130                 135                 140                 


Gln Val Leu Ser Asp Ser Gly Gly Pro Leu Ile Asp Leu Leu Thr Glu 
145                 150                 155                 160 


Asp Pro Pro Pro Tyr Arg Asp Pro Arg Pro Pro Pro Ser Asp Arg Asp 
                165                 170                 175     


Gly Asn Gly Gly Glu Ala Thr Pro Ala Gly Glu Ala Pro Asp Pro Ser 
            180                 185                 190         


Pro Met Ala Ser Arg Leu Arg Gly Arg Arg Glu Pro Pro Val Ala Asp 
        195                 200                 205             


Ser Thr Thr Ser Gln Ala Phe Pro Leu Arg Ala Gly Gly Asn Gly Gln 
    210                 215                 220                 


Leu Gln Tyr Trp Pro Phe Ser Ser Ser Asp Leu Tyr Asn Trp Lys Asn 
225                 230                 235                 240 


Asn Asn Pro Ser Phe Ser Glu Asp Pro Gly Lys Leu Thr Ala Leu Ile 
                245                 250                 255     


Glu Ser Val Leu Ile Thr His Gln Pro Thr Trp Asp Asp Cys Gln Gln 
            260                 265                 270         


Leu Leu Gly Thr Leu Leu Thr Gly Glu Glu Lys Gln Arg Val Leu Leu 
        275                 280                 285             


Glu Ala Arg Lys Ala Val Arg Gly Asp Asp Gly Arg Pro Thr Gln Leu 
    290                 295                 300                 


Pro Asn Glu Val Asp Ala Ala Phe Pro Leu Glu Arg Pro Asp Trp Asp 
305                 310                 315                 320 


Tyr Thr Thr Gln Ala Gly Arg Asn His Leu Val His Tyr Arg Gln Leu 
                325                 330                 335     


Leu Leu Ala Gly Leu Gln Asn Ala Gly Arg Ser Pro Thr Asn Leu Ala 
            340                 345                 350         


Lys Val Lys Gly Ile Thr Gln Gly Pro Asn Glu Ser Pro Ser Ala Phe 
        355                 360                 365             


Leu Glu Arg Leu Lys Glu Ala Tyr Arg Arg Tyr Thr Pro Tyr Asp Pro 
    370                 375                 380                 


Glu Asp Pro Gly Gln Glu Thr Asn Val Ser Met Ser Phe Ile Trp Gln 
385                 390                 395                 400 


Ser Ala Pro Asp Ile Gly Arg Lys Leu Glu Arg Leu Glu Asp Leu Lys 
                405                 410                 415     


Asn Lys Thr Leu Gly Asp Leu Val Arg Glu Ala Glu Lys Ile Phe Asn 
            420                 425                 430         


Lys Arg Glu Thr Pro Glu Glu Arg Glu Glu Arg Ile Arg Arg Glu Thr 
        435                 440                 445             


Glu Glu Lys Glu Glu Arg Arg Arg Thr Glu Asp Glu Gln Lys Glu Lys 
    450                 455                 460                 


Glu Arg Asp Arg Arg Arg His Arg Glu Met Ser Lys Leu Leu Ala Thr 
465                 470                 475                 480 


Val Val Ser Gly Gln Lys Gln Asp Arg Gln Gly Gly Glu Arg Arg Arg 
                485                 490                 495     


Ser Gln Leu Asp Arg Asp Gln Cys Ala Tyr Cys Lys Glu Lys Gly His 
            500                 505                 510         


Trp Ala Lys Asp Cys Pro Lys Lys Pro Arg Gly Pro Arg Gly Pro Arg 
        515                 520                 525             


Pro Gln Thr Ser Leu Leu Thr Leu Asp Asp Gly Gly Gln Gly Gln Glu 
    530                 535                 540                 


Pro Pro Pro Glu Pro Arg Ile Thr Leu Lys Val Gly Gly Gln Pro Val 
545                 550                 555                 560 


Thr Phe Leu Val Asp Thr Gly Ala Gln His Ser Val Leu Thr Gln Asn 
                565                 570                 575     


Pro Gly Pro Leu Ser Asp Lys Ser Ala Trp Val Gln Gly Ala Thr Gly 
            580                 585                 590         


Gly Lys Arg Tyr Arg Trp Thr Thr Asp Arg Lys Val His Leu Ala Thr 
        595                 600                 605             


Gly Lys Val Thr His Ser Phe Leu His Val Pro Asp Cys Pro Tyr Pro 
    610                 615                 620                 


Leu Leu Gly Arg Asp Leu Leu Thr Lys Leu Lys Ala Gln Ile His Phe 
625                 630                 635                 640 


Glu Gly Ser Gly Ala Gln Val Met Gly Pro Met Gly Gln Pro Leu Gln 
                645                 650                 655     


Val Leu Thr Leu Asn Ile Glu Asp Glu His Arg Leu His Glu Thr Ser 
            660                 665                 670         


Lys Glu Pro Asp Val Ser Leu Gly Ser Thr Trp Leu Ser Asp Phe Pro 
        675                 680                 685             


Gln Ala Trp Ala Glu Thr Gly Gly Met Gly Leu Ala Val Arg Gln Ala 
    690                 695                 700                 


Pro Leu Ile Ile Pro Leu Lys Ala Thr Ser Thr Pro Val Ser Ile Lys 
705                 710                 715                 720 


Gln Tyr Pro Met Ser Gln Glu Ala Arg Leu Gly Ile Lys Pro His Ile 
                725                 730                 735     


Gln Arg Leu Leu Asp Gln Gly Ile Leu Val Pro Cys Gln Ser Pro Trp 
            740                 745                 750         


Asn Thr Pro Leu Leu Pro Val Lys Lys Pro Gly Thr Asn Asp Tyr Arg 
        755                 760                 765             


Pro Val Gln Asp Leu Arg Glu Val Asn Lys Arg Val Glu Asp Ile His 
    770                 775                 780                 


Pro Thr Val Pro Asn Pro Tyr Asn Leu Leu Ser Gly Leu Pro Pro Ser 
785                 790                 795                 800 


His Gln Trp Tyr Thr Val Leu Asp Leu Lys Asp Ala Phe Phe Cys Leu 
                805                 810                 815     


Arg Leu His Pro Thr Ser Gln Pro Leu Phe Ala Phe Glu Trp Arg Asp 
            820                 825                 830         


Pro Glu Met Gly Ile Ser Gly Gln Leu Thr Trp Thr Arg Leu Pro Gln 
        835                 840                 845             


Gly Phe Lys Asn Ser Pro Thr Leu Phe Asp Glu Ala Leu His Arg Asp 
    850                 855                 860                 


Leu Ala Asp Phe Arg Ile Gln His Pro Asp Leu Ile Leu Leu Gln Tyr 
865                 870                 875                 880 


Val Asp Asp Leu Leu Leu Ala Ala Thr Ser Glu Leu Asp Cys Gln Gln 
                885                 890                 895     


Gly Thr Arg Ala Leu Leu Gln Thr Leu Gly Asn Leu Gly Tyr Arg Ala 
            900                 905                 910         


Ser Ala Lys Lys Ala Gln Ile Cys Gln Lys Gln Val Lys Tyr Leu Gly 
        915                 920                 925             


Tyr Leu Leu Lys Glu Gly Gln Arg Trp Leu Thr Glu Ala Arg Lys Glu 
    930                 935                 940                 


Thr Val Met Gly Gln Pro Thr Pro Lys Thr Pro Arg Gln Leu Arg Glu 
945                 950                 955                 960 


Phe Leu Gly Thr Ala Gly Phe Cys Arg Leu Trp Ile Pro Gly Phe Ala 
                965                 970                 975     


Glu Met Ala Ala Pro Leu Tyr Pro Leu Thr Lys Thr Gly Thr Leu Phe 
            980                 985                 990         


Asn Trp Gly Pro Asp Gln Gln Lys  Ala Tyr Gln Glu Ile  Lys Gln Ala 
        995                 1000                 1005             


Leu Leu  Thr Ala Pro Ala Leu  Gly Leu Pro Asp Leu  Thr Lys Pro 
    1010                 1015                 1020             


Phe Glu  Leu Phe Val Asp Glu  Lys Gln Gly Tyr Ala  Lys Gly Val 
    1025                 1030                 1035             


Leu Thr  Gln Lys Leu Gly Pro  Trp Arg Arg Pro Val  Ala Tyr Leu 
    1040                 1045                 1050             


Ser Lys  Lys Leu Asp Pro Val  Ala Ala Gly Trp Pro  Pro Cys Leu 
    1055                 1060                 1065             


Arg Met  Val Ala Ala Ile Ala  Val Leu Thr Lys Asp  Ala Gly Lys 
    1070                 1075                 1080             


Leu Thr  Met Gly Gln Pro Leu  Val Ile Leu Ala Pro  His Ala Val 
    1085                 1090                 1095             


Glu Ala  Leu Val Lys Gln Pro  Pro Asp Arg Trp Leu  Ser Asn Ala 
    1100                 1105                 1110             


Arg Met  Thr His Tyr Gln Ala  Leu Leu Leu Asp Thr  Asp Arg Val 
    1115                 1120                 1125             


Gln Phe  Gly Pro Val Val Ala  Leu Asn Pro Ala Thr  Leu Leu Pro 
    1130                 1135                 1140             


Leu Pro  Glu Glu Gly Leu Gln  His Asn Cys Leu Asp  Ile Leu Ala 
    1145                 1150                 1155             


Glu Ala  His Gly Thr Arg Pro  Asp Leu Thr Asp Gln  Pro Leu Pro 
    1160                 1165                 1170             


Asp Ala  Asp His Thr Trp Tyr  Thr Asp Gly Ser Ser  Leu Leu Gln 
    1175                 1180                 1185             


Glu Gly  Gln Arg Lys Ala Gly  Ala Ala Val Thr Thr  Glu Thr Glu 
    1190                 1195                 1200             


Val Ile  Trp Ala Lys Ala Leu  Pro Ala Gly Thr Ser  Ala Gln Arg 
    1205                 1210                 1215             


Ala Glu  Leu Ile Ala Leu Thr  Gln Ala Leu Lys Met  Ala Glu Gly 
    1220                 1225                 1230             


Lys Lys  Leu Asn Val Tyr Thr  Asp Ser Arg Tyr Ala  Phe Ala Thr 
    1235                 1240                 1245             


Ala His  Ile His Gly Glu Ile  Tyr Arg Arg Arg Gly  Leu Leu Thr 
    1250                 1255                 1260             


Ser Glu  Gly Lys Glu Ile Lys  Asn Lys Asp Glu Ile  Leu Ala Leu 
    1265                 1270                 1275             


Leu Lys  Ala Leu Phe Leu Pro  Lys Arg Leu Ser Ile  Ile His Cys 
    1280                 1285                 1290             


Pro Gly  His Gln Lys Gly His  Ser Ala Glu Ala Arg  Gly Asn Arg 
    1295                 1300                 1305             


Met Ala  Asp Gln Ala Ala Arg  Lys Ala Ala Ile Thr  Glu Thr Pro 
    1310                 1315                 1320             


Asp Thr  Ser Thr Leu Leu Ile  Glu Asn Ser Ser Pro  Tyr Thr Ser 
    1325                 1330                 1335             


Glu His  Phe His Tyr Thr Val  Thr Asp Ile Lys Asp  Leu Thr Lys 
    1340                 1345                 1350             


Leu Gly  Ala Ile Tyr Asp Lys  Thr Lys Lys Tyr Trp  Val Tyr Gln 
    1355                 1360                 1365             


Gly Lys  Pro Val Met Pro Asp  Gln Phe Thr Phe Glu  Leu Leu Asp 
    1370                 1375                 1380             


Phe Leu  His Gln Leu Thr His  Leu Ser Phe Ser Lys  Met Lys Ala 
    1385                 1390                 1395             


Leu Leu  Glu Arg Ser His Ser  Pro Tyr Tyr Met Leu  Asn Arg Asp 
    1400                 1405                 1410             


Arg Thr  Leu Lys Asn Ile Thr  Glu Thr Cys Lys Ala  Cys Ala Gln 
    1415                 1420                 1425             


Val Asn  Ala Ser Lys Ser Ala  Val Lys Gln Gly Thr  Arg Val Arg 
    1430                 1435                 1440             


Gly His  Arg Pro Gly Thr His  Trp Glu Ile Asp Phe  Thr Glu Ile 
    1445                 1450                 1455             


Lys Pro  Gly Leu Tyr Gly Tyr  Lys Tyr Leu Leu Val  Phe Ile Asp 
    1460                 1465                 1470             


Thr Phe  Ser Gly Trp Ile Glu  Ala Phe Pro Thr Lys  Lys Glu Thr 
    1475                 1480                 1485             


Ala Lys  Val Val Thr Lys Lys  Leu Leu Glu Glu Ile  Phe Pro Arg 
    1490                 1495                 1500             


Phe Gly  Met Pro Gln Val Leu  Gly Thr Asp Asn Gly  Pro Ala Phe 
    1505                 1510                 1515             


Val Ser  Lys Val Ser Gln Thr  Val Ala Asp Leu Leu  Gly Ile Asp 
    1520                 1525                 1530             


Trp Lys  Leu His Cys Ala Tyr  Arg Pro Gln Ser Ser  Gly Gln Val 
    1535                 1540                 1545             


Glu Arg  Met Asn Arg Thr Ile  Lys Glu Thr Leu Thr  Lys Leu Thr 
    1550                 1555                 1560             


Leu Ala  Thr Gly Ser Arg Asp  Trp Val Leu Leu Leu  Pro Leu Ala 
    1565                 1570                 1575             


Leu Tyr  Arg Ala Arg Asn Thr  Pro Gly Pro His Gly  Leu Thr Pro 
    1580                 1585                 1590             


Tyr Glu  Ile Leu Tyr Gly Ala  Pro Pro Pro Leu Val  Asn Phe Pro 
    1595                 1600                 1605             


Asp Pro  Asp Met Thr Arg Val  Thr Asn Ser Pro Ser  Leu Gln Ala 
    1610                 1615                 1620             


His Leu  Gln Ala Leu Tyr Leu  Val Gln His Glu Val  Trp Arg Pro 
    1625                 1630                 1635             


Leu Ala  Ala Ala Tyr Gln Glu  Gln Leu Asp Arg Pro  Val Val Pro 
    1640                 1645                 1650             


His Pro  Tyr Arg Val Gly Asp  Thr Val Trp Val Arg  Arg His Gln 
    1655                 1660                 1665             


Thr Lys  Asn Leu Glu Pro Arg  Trp Lys Gly Pro Tyr  Thr Val Leu 
    1670                 1675                 1680             


Leu Thr  Thr Pro Thr Ala Leu  Lys Val Asp Gly Ile  Ala Ala Trp 
    1685                 1690                 1695             


Ile His  Ala Ala His Val Lys  Ala Ala Asp Pro Gly  Gly Gly Pro 
    1700                 1705                 1710             


Ser Ser  Arg Leu Thr Trp Arg  Val Gln Arg Ser Gln  Asn Pro Leu 
    1715                 1720                 1725             


Lys Ile  Arg Leu Thr Arg Glu  Ala Pro 
    1730                 1735         


<210>  38
<211>  43
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Forward Primer Murine Ppgk

<400>  38
aattaaacgc gttcgcgaca attctaccgg gtaggggagg cgc                         43


<210>  39
<211>  35
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Reverse Primer murine Ppgk

<400>  39
aattaaatcg atggtggcgg gatgcaggtc gaaag                                  35


<210>  40
<211>  529
<212>  DNA
<213>  Mus musculus

<220>
<223>  Murine Ppgk nucleic acid

<400>  40
caattctacc gggtagggga ggcgcttttc ccaaggcagt ctggagcatg cgctttagca       60

gccccgctgg gcacttggcg ctacacaagt ggcctctggc ctcgcacaca ttccacatcc      120

accggtaggc gccaaccggc tccgttcttt ggtggcccct tcgcgccacc ttctactcct      180

cccctagtca ggaagtttcc cccccgcccc gcagctcgcg tcgagcagga cgtgacaaat      240

ggaagtagca cgtctcacta gtctcgtgca gatggacagc accgctgagc aatggaagcg      300

ggtaggcctt tggggcaacg gccaatagca gctttgctcc ttcgctttct gggctcagag      360

gctgggaagg ggtgggtccg ggggcgggct caggggcggg ctcaggggcg gggcgggcgc      420

ccgaaggtcc tccggaggcc cggcattctg cacgcttcaa aagcgcacgt ctgccgcgct      480

gttctcctct tcctcatctc cgggcctttc gacctgcatc ccgccacca                  529


<210>  41
<211>  1215
<212>  DNA
<213>  Mus musculus

<220>
<223>  Vkappa promoter nucleic acid

<400>  41
agcttttgtg tttgaccctt ccctagccaa aggcaactat ttaaggaccc tttaaaactc       60

ttgaaactac tttagagtca ttaagtaatt taaccacttt taattacttt aaaatgatgt      120

caactccctt ttaactatta atttatttta aggggggaaa ggctgctcat aattctattg      180

tttttcttgg taaagaactc tcagttttcg tttttactac ctctgtcacc caagagttgg      240

catctcaaca gaggggactt tccgagaggc catctggcag ttgcttaaga tcagaagtga      300

agtctgccag ttcctcccag gcaggtggcc cagattacag ttgacctgtt ctggtgtggc      360

taaaaattgt cccatgtggt tacagaccat tagaccaggg tctgatgaat tgctcagaat      420

gtttctggac acccaaatac agaccctggc ttaaggacct gtccatacag taggtttagc      480

ttggctacac caaaggaagc catagagagg ctaatattag agtattcttg gaagagacag      540

gagaaaatga aagccagttt ctgctcttac cttatgtgct tgtgttcaga ctcccaaaca      600

tcaggagtgt cagataaact ggtctggatc tctgtctgaa gcatggaact gaaaagaatg      660

tagtttcagg gaagaaaggc aatagaggga agcctgagat tatcttcaaa gggtcagact      720

caatttactt tctaaagaag tagctaggaa ctagggaata acttagaaac aacaagatcg      780

tatatatgtg catcctggcc ccattgttcc ttatctgtag ggataagcgt gcttttttgt      840

gtgtctgtct ataacataac tgtttacaca taatacactg aaatggagcc cttccttgtt      900

acttcatacc atcctctgtg cttccttcct cagatcgatc ctggtctaca gtgtgaggta      960

ctggacgacc aagaatagag aaacctgtct caaaaaaatg tatttagaag ggtcccttaa     1020

gacacatgtg atgttctagt aaattttctg ctaacaccaa cttcctctgg gtgaaacagg     1080

ggcaggtgca catggagaaa cagtacatac tctgctgatt tgcatatgaa ataattttat     1140

aacagcccag gcttctttaa gggcagctgc caggagccta ataaagcatc ctctcttcca     1200

gctctcagag gatct                                                      1215


<210>  42
<211>  5021
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  pIRES-puro

<400>  42
gacggatcgg gagatctccc gatcccctat ggtcgactct cagtacaatc tgctctgatg       60

ccgcatagtt aagccagtat ctgctccctg cttgtgtgtt ggaggtcgct gagtagtgcg      120

cgagcaaaat ttaagctaca acaaggcaag gcttgaccga caattgcatg aagaatctgc      180

ttagggttag gcgttttgcg ctgcttcgcg atgtacgggc cagatatacg cgttgacatt      240

gattattgac tagttattaa tagtaatcaa ttacggggtc attagttcat agcccatata      300

tggagttccg cgttacataa cttacggtaa atggcccgcc tggctgaccg cccaacgacc      360

cccgcccatt gacgtcaata atgacgtatg ttcccatagt aacgccaata gggactttcc      420

attgacgtca atgggtggac tatttacggt aaactgccca cttggcagta catcaagtgt      480

atcatatgcc aagtacgccc cctattgacg tcaatgacgg taaatggccc gcctggcatt      540

atgcccagta catgacctta tgggactttc ctacttggca gtacatctac gtattagtca      600

tcgctattac catggtgatg cggttttggc agtacatcaa tgggcgtgga tagcggtttg      660

actcacgggg atttccaagt ctccacccca ttgacgtcaa tgggagtttg ttttggcacc      720

aaaatcaacg ggactttcca aaatgtcgta acaactccgc cccattgacg caaatgggcg      780

gtaggcgtgt acggtgggag gtctatataa gcagagctct ctggctaact agagaaccca      840

ctgcttactg gcttatcgaa attaatacga ctcactatag ggagacccaa gcttggtacc      900

gagctcggat cgatatctgc ggccgcgtcg acggaattca gtggatccac tagtaacggc      960

cgccagtgtg ctggaattaa ttcgctgtct gcgagggcca gctgttgggg tgagtactcc     1020

ctctcaaaag cgggcatgac ttctgcgcta agattgtcag tttccaaaaa cgaggaggat     1080

ttgatattca cctggcccgc ggtgatgcct ttgagggtgg ccgcgtccat ctggtcagaa     1140

aagacaatct ttttgttgtc aagcttgagg tgtggcaggc ttgagatctg gccatacact     1200

tgagtgacaa tgacatccac tttgcctttc tctccacagg tgtccactcc caggtccaac     1260

tgcaggtcga gcatgcatct agggcggcca attccgcccc tctccctccc ccccccctaa     1320

cgttactggc cgaagccgct tggaataagg ccggtgtgcg tttgtctata tgtgattttc     1380

caccatattg ccgtcttttg gcaatgtgag ggcccggaaa cctggccctg tcttcttgac     1440

gagcattcct aggggtcttt cccctctcgc caaaggaatg caaggtctgt tgaatgtcgt     1500

gaaggaagca gttcctctgg aagcttcttg aagacaaaca acgtctgtag cgaccctttg     1560

caggcagcgg aaccccccac ctggcgacag gtgcctctgc ggccaaaagc cacgtgtata     1620

agatacacct gcaaaggcgg cacaacccca gtgccacgtt gtgagttgga tagttgtgga     1680

aagagtcaaa tggctctcct caagcgtatt caacaagggg ctgaaggatg cccagaaggt     1740

accccattgt atgggatctg atctggggcc tcggtgcaca tgctttacat gtgtttagtc     1800

gaggttaaaa aaacgtctag gccccccgaa ccacggggac gtggttttcc tttgaaaaac     1860

acgatgataa gcttgccaca acccgggatg accgagtaca agcccacggt gcgcctcgcc     1920

acccgcgacg acgtccccag ggccgtacgc accctcgccg ccgcgttcgc cgactacccc     1980

gccacgcgcc acaccgtcga tccggaccgc cacatcgagc gggtcaccga gctgcaagaa     2040

ctcttcctca cgcgcgtcgg gctcgacatc ggcaaggtgt gggtcgcgga cgacggcgcc     2100

gcggtggcgg tctggaccac gccggagagc gtcgaagcgg gggcggtgtt cgccgagatc     2160

ggcccgcgca tggccgagtt gagcggttcc cggctggccg cgcagcaaca gatggaaggc     2220

ctcctggcgc cgcaccggcc caaggagccc gcgtggttcc tggccaccgt cggcgtctcg     2280

cccgaccacc agggcaaggg tctgggcagc gccgtcgtgc tccccggagt ggaggcggcc     2340

gagcgcgccg gggtgcccgc cttcctggag acctccgcgc cccgcaacct ccccttctac     2400

gagcggctcg gcttcaccgt caccgccgac gtcgaggtgc ccgaaggacc gcgcacctgg     2460

tgcatgaccc gcaagcccgg tgcctgactc tagagctcgc tgatcagcct cgactgtgcc     2520

ttctagttgc cagccatctg ttgtttgccc ctcccccgtg ccttccttga ccctggaagg     2580

tgccactccc actgtccttt cctaataaaa tgaggaaatt gcatcgcatt gtctgagtag     2640

gtgtcattct attctggggg gtggggtggg gcaggacagc aagggggagg attgggaaga     2700

caatagcagg catgctgggg atgcggtggg ctctatggct tctgaggcgg aaagaaccag     2760

ctggggctcg agtgcattct agttgtggtt tgtccaaact catcaatgta tcttatcatg     2820

tctgtatacc gtcgacctct agctagagct tggcgtaatc atggtcatag ctgtttcctg     2880

tgtgaaattg ttatccgctc acaattccac acaacatacg agccggaagc ataaagtgta     2940

aagcctgggg tgcctaatga gtgagctaac tcacattaat tgcgttgcgc tcactgcccg     3000

ctttccagtc gggaaacctg tcgtgccagc tgcattaatg aatcggccaa cgcgcgggga     3060

gaggcggttt gcgtattggg cgctcttccg cttcctcgct cactgactcg ctgcgctcgg     3120

tcgttcggct gcggcgagcg gtatcagctc actcaaaggc ggtaatacgg ttatccacag     3180

aatcagggga taacgcagga aagaacatgt gagcaaaagg ccagcaaaag gccaggaacc     3240

gtaaaaaggc cgcgttgctg gcgtttttcc ataggctccg cccccctgac gagcatcaca     3300

aaaatcgacg ctcaagtcag aggtggcgaa acccgacagg actataaaga taccaggcgt     3360

ttccccctgg aagctccctc gtgcgctctc ctgttccgac cctgccgctt accggatacc     3420

tgtccgcctt tctcccttcg ggaagcgtgg cgctttctca atgctcacgc tgtaggtatc     3480

tcagttcggt gtaggtcgtt cgctccaagc tgggctgtgt gcacgaaccc cccgttcagc     3540

ccgaccgctg cgccttatcc ggtaactatc gtcttgagtc caacccggta agacacgact     3600

tatcgccact ggcagcagcc actggtaaca ggattagcag agcgaggtat gtaggcggtg     3660

ctacagagtt cttgaagtgg tggcctaact acggctacac tagaaggaca gtatttggta     3720

tctgcgctct gctgaagcca gttaccttcg gaaaaagagt tggtagctct tgatccggca     3780

aacaaaccac cgctggtagc ggtggttttt ttgtttgcaa gcagcagatt acgcgcagaa     3840

aaaaaggatc tcaagaagat cctttgatct tttctacggg gtctgacgct cagtggaacg     3900

aaaactcacg ttaagggatt ttggtcatga gattatcaaa aaggatcttc acctagatcc     3960

ttttaaatta aaaatgaagt tttaaatcaa tctaaagtat atatgagtaa acttggtctg     4020

acagttacca atgcttaatc agtgaggcac ctatctcagc gatctgtcta tttcgttcat     4080

ccatagttgc ctgactcccc gtcgtgtaga taactacgat acgggagggc ttaccatctg     4140

gccccagtgc tgcaatgata ccgcgagacc cacgctcacc ggctccagat ttatcagcaa     4200

taaaccagcc agccggaagg gccgagcgca gaagtggtcc tgcaacttta tccgcctcca     4260

tccagtctat taattgttgc cgggaagcta gagtaagtag ttcgccagtt aatagtttgc     4320

gcaacgttgt tgccattgct acaggcatcg tggtgtcacg ctcgtcgttt ggtatggctt     4380

cattcagctc cggttcccaa cgatcaaggc gagttacatg atcccccatg ttgtgcaaaa     4440

aagcggttag ctccttcggt cctccgatcg ttgtcagaag taagttggcc gcagtgttat     4500

cactcatggt tatggcagca ctgcataatt ctcttactgt catgccatcc gtaagatgct     4560

tttctgtgac tggtgagtac tcaaccaagt cattctgaga atagtgtatg cggcgaccga     4620

gttgctcttg cccggcgtca atacgggata ataccgcgcc acatagcaga actttaaaag     4680

tgctcatcat tggaaaacgt tcttcggggc gaaaactctc aaggatctta ccgctgttga     4740

gatccagttc gatgtaaccc actcgtgcac ccaactgatc ttcagcatct tttactttca     4800

ccagcgtttc tgggtgagca aaaacaggaa ggcaaaatgc cgcaaaaaag ggaataaggg     4860

cgacacggaa atgttgaata ctcatactct tcctttttca atattattga agcatttatc     4920

agggttattg tctcatgagc ggatacatat ttgaatgtat ttagaaaaat aaacaaatag     4980

gggttccgcg cacatttccc cgaaaagtgc cacctgacgt c                         5021


<210>  43
<211>  6231
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  MigR1 vector

<400>  43
agtgaaagac cccacctgta ggtttggcaa gctagcttaa gtaacgccat tttgcaaggc       60

atggaaaata cataactgag aatagagaag ttcagatcaa ggttaggaac agagagacag      120

cagaatatgg gccaaacagg atatctgtgg taagcagttc ctgccccggc tcagggccaa      180

gaacagatgg tccccagatg cggtcccgcc ctcagcagtt tctagagaac catcagatgt      240

ttccagggtg ccccaaggac ctgaaaatga ccctgtgcct tatttgaact aaccaatcag      300

ttcgcttctc gcttctgttc gcgcgcttct gctccccgag ctcaataaaa gagcccacaa      360

cccctcactc ggcgcgccag tcctccgata gactgcgtcg cccgggtacc cgtattccca      420

ataaagcctc ttgctgtttg catccgaatc gtggactcgc tgatccttgg gagggtctcc      480

tcagattgat tgactgccca cctcgggggt ctttcatttg gaggttccac cgagatttgg      540

agacccctgc ctagggacca ccgacccccc cgccgggagg taagctggcc agcggtcgtt      600

tcgtgtctgt ctctgtcttt gtgcgtgttt gtgccggcat ctaatgtttg cgcctgcgtc      660

tgtactagtt agctaactag ctctgtatct ggcggacccg tggtggaact gacgagttct      720

gaacacccgg ccgcaaccct gggagacgtc ccagggactt tgggggccgt ttttgtggcc      780

cgacctgagg aagggagtcg atgtggaatc cgaccccgtc aggatatgtg gttctggtag      840

gagacgagaa cctaaaacag ttcccgcctc cgtctgaatt tttgctttcg gtttggaacc      900

gaagccgcgc gtcttgtctg ctgcagcgct gcagcatcgt tctgtgttgt ctctgtctga      960

ctgtgtttct gtatttgtct gaaaattagg gccagactgt taccactccc ttaagtttga     1020

ccttaggtca ctggaaagat gtcgagcgga tcgctcacaa ccagtcggta gatgtcaaga     1080

agagacgttg ggttaccttc tgctctgcag aatggccaac ctttaacgtc ggatggccgc     1140

gagacggcac ctttaaccga gacctcatca cccaggttaa gatcaaggtc ttttcacctg     1200

gcccgcatgg acacccagac caggtcccct acatcgtgac ctgggaagcc ttggcttttg     1260

acccccctcc ctgggtcaag ccctttgtac accctaagcc tccgcctcct cttcctccat     1320

ccgccccgtc tctccccctt gaacctcctc gttcgacccc gcctcgatcc tccctttatc     1380

cagccctcac tccttctcta ggcgccggaa ttagatctct cgaggttaac gaattccgcc     1440

cctctccctc ccccccccct aacgttactg gccgaagccg cttggaataa ggccggtgtg     1500

cgtttgtcta tatgttattt tccaccatat tgccgtcttt tggcaatgtg agggcccgga     1560

aacctggccc tgtcttcttg acgagcattc ctaggggtct ttcccctctc gccaaaggaa     1620

tgcaaggtct gttgaatgtc gtgaaggaag cagttcctct ggaagcttct tgaagacaaa     1680

caacgtctgt agcgaccctt tgcaggcagc ggaacccccc acctggcgac aggtgcctct     1740

gcggccaaaa gccacgtgta taagatacac ctgcaaaggc ggcacaaccc cagtgccacg     1800

ttgtgagttg gatagttgtg gaaagagtca aatggctctc ctcaagcgta ttcaacaagg     1860

ggctgaagga tgcccagaag gtaccccatt gtatgggatc tgatctgggg cctcggtgca     1920

catgctttac atgtgtttag tcgaggttaa aaaacgtcta ggccccccga accacgggga     1980

cgtggttttc ctttgaaaaa cacgatgata atatggccac aaccatggtg agcaagggcg     2040

aggagctgtt caccggggtg gtgcccatcc tggtcgagct ggacggcgac gtaaacggcc     2100

acaagttcag cgtgtccggc gagggcgagg gcgatgccac ctacggcaag ctgaccctga     2160

agttcatctg caccaccggc aagctgcccg tgccctggcc caccctcgtg accaccctga     2220

cctacggcgt gcagtgcttc agccgctacc ccgaccacat gaagcagcac gacttcttca     2280

agtccgccat gcccgaaggc tacgtccagg agcgcaccat cttcttcaag gacgacggca     2340

actacaagac ccgcgccgag gtgaagttcg agggcgacac cctggtgaac cgcatcgagc     2400

tgaagggcat cgacttcaag gaggacggca acatcctggg gcacaagctg gagtacaact     2460

acaacagcca caacgtctat atcatggccg acaagcagaa gaacggcatc aaggtgaact     2520

tcaagatccg ccacaacatc gaggacggca gcgtgcagct cgccgaccac taccagcaga     2580

acacccccat cggcgacggc cccgtgctgc tgcccgacaa ccactacctg agcacccagt     2640

ccgccctgag caaagacccc aacgagaagc gcgatcacat ggtcctgctg gagttcgtga     2700

ccgccgccgg gatcactctc ggcatggacg agctgtacaa gtaagtcgac ctgcagccaa     2760

gcttatcgat aaaataaaag attttattta gtctccagaa aaagggggga atgaaagacc     2820

ccacctgtag gtttggcaag ctagcttaag taacgccatt ttgcaaggca tggaaaatac     2880

ataactgaga atagagaagt tcagatcaag gttaggaaca gagagacagc agaatatggg     2940

ccaaacagga tatctgtggt aagcagttcc tgccccggct cagggccaag aacagatggt     3000

ccccagatgc ggtcccgccc tcagcagttt ctagagaacc atcagatgtt tccagggtgc     3060

cccaaggacc tgaaaatgac cctgtgcctt atttgaacta accaatcagt tcgcttctcg     3120

cttctgttcg cgcgcttctg ctccccgagc tcaataaaag agcccacaac ccctcactcg     3180

gcgcgccagt cctccgatag actgcgtcgc ccgggtaccc gtgtatccaa taaaccctct     3240

tgcagttgca tccgacttgt ggtctcgctg ttccttggga gggtctcctc tgagtgattg     3300

actacccgtc agcgggggtc tttcagaatt ggtaatcatg gtcatagctg tttcctgtgt     3360

gaaattgtta tccgctcaca attccacaca acatacgagc cggaagcata aagtgtaaag     3420

cctggggtgc ctaatgagtg agctaactca cattaattgc gttgcgctca ctgcccgctt     3480

tccagtcggg aaacctgtcg tgccagctgc attaatgaat cggccaacgc gcggggagag     3540

gcggtttgcg tattgggcgc tcttccgctt cctcgctcac tgactcgctg cgctcggtcg     3600

ttcggctgcg gcgagcggta tcagctcact caaaggcggt aatacggtta tccacagaat     3660

caggggataa cgcaggaaag aacatgtgag caaaaggcca gcaaaaggcc aggaaccgta     3720

aaaaggccgc gttgctggcg tttttccata ggctccgccc ccctgacgag catcacaaaa     3780

atcgacgctc aagtcagagg tggcgaaacc cgacaggact ataaagatac caggcgtttc     3840

cccctggaag ctccctcgtg cgctctcctg ttccgaccct gccgcttacc ggatacctgt     3900

ccgcctttct cccttcggga agcgtggcgc tttctcatag ctcacgctgt aggtatctca     3960

gttcggtgta ggtcgttcgc tccaagctgg gctgtgtgca cgaacccccc gttcagcccg     4020

accgctgcgc cttatccggt aactatcgtc ttgagtccaa cccggtaaga cacgacttat     4080

cgccactggc agcagccact ggtaacagga ttagcagagc gaggtatgta ggcggtgcta     4140

cagagttctt gaagtggtgg cctaactacg gctacactag aaggacagta tttggtatct     4200

gcgctctgct gaagccagtt accttcggaa aaagagttgg tagctcttga tccggcaaac     4260

aaaccaccgc tggtagcggt ggtttttttg tttgcaagca gcagattacg cgcagaaaaa     4320

aaggatctca agaagatcct ttgatctttt ctacggggtc tgacgctcag tggaacgaaa     4380

actcacgtta agggattttg gtcatgagat tatcaaaaag gatcttcacc tagatccttt     4440

taaattaaaa atgaagtttt aaatcaatct aaagtatata tgagtaaact tggtctgaca     4500

gttaccaatg cttaatcagt gaggcaccta tctcagcgat ctgtctattt cgttcatcca     4560

tagttgcctg actccccgtc gtgtagataa ctacgatacg ggagggctta ccatctggcc     4620

ccagtgctgc aatgataccg cgagacccac gctcaccggc tccagattta tcagcaataa     4680

accagccagc cggaagggcc gagcgcagaa gtggtcctgc aactttatcc gcctccatcc     4740

agtctattaa ttgttgccgg gaagctagag taagtagttc gccagttaat agtttgcgca     4800

acgttgttgc cattgctaca ggcatcgtgg tgtcacgctc gtcgtttggt atggcttcat     4860

tcagctccgg ttcccaacga tcaaggcgag ttacatgatc ccccatgttg tgcaaaaaag     4920

cggttagctc cttcggtcct ccgatcgttg tcagaagtaa gttggccgca gtgttatcac     4980

tcatggttat ggcagcactg cataattctc ttactgtcat gccatccgta agatgctttt     5040

ctgtgactgg tgagtactca accaagtcat tctgagaata gtgtatgcgg cgaccgagtt     5100

gctcttgccc ggcgtcaata cgggataata ccgcgccaca tagcagaact ttaaaagtgc     5160

tcatcattgg aaaacgttct tcggggcgaa aactctcaag gatcttaccg ctgttgagat     5220

ccagttcgat gtaacccact cgtgcaccca actgatcttc agcatctttt actttcacca     5280

gcgtttctgg gtgagcaaaa acaggaaggc aaaatgccgc aaaaaaggga ataagggcga     5340

cacggaaatg ttgaatactc atactcttcc tttttcaata ttattgaagc atttatcagg     5400

gttattgtct catgagcgga tacatatttg aatgtattta gaaaaataaa caaatagggg     5460

ttccgcgcac atttccccga aaagtgccac ctgacgtcta agaaaccatt attatcatga     5520

cattaaccta taaaaatagg cgtatcacga ggccctttcg tctcgcgcgt ttcggtgatg     5580

acggtgaaaa cctctgacac atgcagctcc cggagacggt cacagcttgt ctgtaagcgg     5640

atgccgggag cagacaagcc cgtcagggcg cgtcagcggg tgttggcggg tgtcggggct     5700

ggcttaacta tgcggcatca gagcagattg tactgagagt gcaccatatg cggtgtgaaa     5760

taccgcacag atgcgtaagg agaaaatacc gcatcaggcg ccattcgcca ttcaggctgc     5820

gcaactgttg ggaagggcga tcggtgcggg cctcttcgct attacgccag ctggcgaaag     5880

ggggatgtgc tgcaaggcga ttaagttggg taacgccagg gttttcccag tcacgacgtt     5940

gtaaaacgac ggccagtgcc acgctctccc ttatgcgact cctgcattag gaagcagccc     6000

agtagtaggt tgaggccgtt gagcaccgcc gccgcaagga atggtgcatg caaggagatg     6060

gcgcccaaca gtcccccggc cacggggcct gccaccatac ccacgccgaa acaagcgctc     6120

atgagcccga agtggcgagc ccgatcttcc ccatcggtga tgtcggcgat ataggcgcca     6180

gcaaccgcac ctgtggcgcc ggtgatgccg gccacgatgc gtccggcgta g              6231


<210>  44
<211>  49
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Forward primer VEGF121

<400>  44
aataagcggc cgcgccacca tgaactttct gctgtcttgg gtgcattgg                   49


<210>  45
<211>  68
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Reverse primer VEGF121

<400>  45
ataattgaat tctcaatgat gatgatgatg atgatctccc cgcctcggct tgtcacattt       60

ttcttgtc                                                                68


<210>  46
<211>  468
<212>  DNA
<213>  Homo sapiens

<220>
<223>  VEGF121-6xHis nucleic acid

<400>  46
atgaactttc tgctgtcttg ggtgcattgg agccttgcct tgctgctcta cctccaccat       60

gccaagtggt cccaggctgc acccatggca gaaggaggag ggcagaatca tcacgaagtg      120

gtgaagttca tggatgtcta tcagcgcagc tactgccatc caatcgagac cctggtggac      180

atcttccagg agtaccctga tgagatcgag tacatcttca agccatcctg tgtgcccctg      240

atgcgatgcg ggggctgctg caatgacgag ggcctggagt gtgtgcccac tgaggagtcc      300

aacatcacca tgcagattat gcggatcaaa cctcaccaag gccagcacat aggagagatg      360

agcttcctac agcacaacaa atgtgaatgc agaccaaaga aagatagagc aagacaagaa      420

aaatgtgaca agccgaggcg gggagatcat catcatcatc atcattga                   468


<210>  47
<211>  155
<212>  PRT
<213>  Homo sapiens

<220>
<223>  VEGF121-6xHis amino acid

<400>  47

Met Asn Phe Leu Leu Ser Trp Val His Trp Ser Leu Ala Leu Leu Leu 
1               5                   10                  15      


Tyr Leu His His Ala Lys Trp Ser Gln Ala Ala Pro Met Ala Glu Gly 
            20                  25                  30          


Gly Gly Gln Asn His His Glu Val Val Lys Phe Met Asp Val Tyr Gln 
        35                  40                  45              


Arg Ser Tyr Cys His Pro Ile Glu Thr Leu Val Asp Ile Phe Gln Glu 
    50                  55                  60                  


Tyr Pro Asp Glu Ile Glu Tyr Ile Phe Lys Pro Ser Cys Val Pro Leu 
65                  70                  75                  80  


Met Arg Cys Gly Gly Cys Cys Asn Asp Glu Gly Leu Glu Cys Val Pro 
                85                  90                  95      


Thr Glu Glu Ser Asn Ile Thr Met Gln Ile Met Arg Ile Lys Pro His 
            100                 105                 110         


Gln Gly Gln His Ile Gly Glu Met Ser Phe Leu Gln His Asn Lys Cys 
        115                 120                 125             


Glu Cys Arg Pro Lys Lys Asp Arg Ala Arg Gln Glu Lys Cys Asp Lys 
    130                 135                 140                 


Pro Arg Arg Gly Asp His His His His His His 
145                 150                 155 


<210>  48
<211>  478
<212>  DNA
<213>  Mus musculus

<220>
<223>  kappa intron enhancer

<400>  48
agcttttgtg tttgaccctt ccctgccaaa ggcaactatt taaggaccct ttaaaactct       60

tgaaactact ttagagtcat taagttattt aaccactttt aattacttta aaatgatgtc      120

aattcccttt taactattaa tttattttaa ggggggaaag gctgctcata attctattgt      180

ttttcttggt aaagaactct cagtttctgt tttactacct ctgtcaccca agagttggca      240

tctcaacaga ggggactttc cgagagccat ctggcagttg cttaagatca gaagtgaagt      300

ctgccagttc ctcctaggca ggtggcccag attacagttg acctgttctg gtgtggctaa      360

aaattgtccc atgtggttac aaaccattag accagggtct gatgaattgc tcagaatatt      420

tctggacacc caaatacaga ccctggctta aggcctgtcc atacagtagg tttagctt        478


<210>  49
<211>  411
<212>  DNA
<213>  Homo sapiens

<220>
<223>  146B7 Vh nucleic acid

<400>  49
atggggtcaa ccgccatcct cgccctcctc ctggctgttc tccaaggagt ctgtgccgag       60

gtgcagctgg tgcagtctgg agcagaggtg aaaaagcccg gggagtctct gaagatctcc      120

tgtaaggttt ctggatactt ctttaccacc tactggatcg gctgggtgcg ccagatgccc      180

gggaaaggcc tggagtatat ggggatcatc tatcctggtg actctgatac cagatacagc      240

ccgtccttcc aaggccaggt caccatctca gccgacaagt ccatcagcac cgcctacctg      300

cagtggagca gcctgaaggc ctcggacacc gccatgtatt actgtgcgag agggggtaac      360

tggaactgct ttgactactg gggccaggga accctggtca ccgtctccag c               411


<210>  50
<211>  137
<212>  PRT
<213>  Homo sapiens

<220>
<223>  146B7 Vh amino acid

<400>  50

Met Gly Ser Thr Ala Ile Leu Ala Leu Leu Leu Ala Val Leu Gln Gly 
1               5                   10                  15      


Val Cys Ala Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys 
            20                  25                  30          


Pro Gly Glu Ser Leu Lys Ile Ser Cys Lys Val Ser Gly Tyr Phe Phe 
        35                  40                  45              


Thr Thr Tyr Trp Ile Gly Trp Val Arg Gln Met Pro Gly Lys Gly Leu 
    50                  55                  60                  


Glu Tyr Met Gly Ile Ile Tyr Pro Gly Asp Ser Asp Thr Arg Tyr Ser 
65                  70                  75                  80  


Pro Ser Phe Gln Gly Gln Val Thr Ile Ser Ala Asp Lys Ser Ile Ser 
                85                  90                  95      


Thr Ala Tyr Leu Gln Trp Ser Ser Leu Lys Ala Ser Asp Thr Ala Met 
            100                 105                 110         


Tyr Tyr Cys Ala Arg Gly Gly Asn Trp Asn Cys Phe Asp Tyr Trp Gly 
        115                 120                 125             


Gln Gly Thr Leu Val Thr Val Ser Ser 
    130                 135         


<210>  51
<211>  992
<212>  DNA
<213>  Homo sapiens

<220>
<223>  sIgH constant region nucleic acid

<400>  51
cctccaccaa gggcccatcg gtcttccccc tggcaccctc ctccaagagc acctctgggg       60

gcacagcggc cctgggctgc ctggtcaagg actacttccc cgaaccggtg acggtgtcgt      120

ggaactcagg cgccctgacc agcggcgtgc acaccttccc ggctgtccta cagtcctcag      180

gactctactc cctcagcagc gtggtgaccg tgccctccag cagcttgggc acccagacct      240

acatctgcaa cgtgaatcac aagcccagca acaccaaggt ggacaagaaa gttgagccca      300

aatcttgtga caaaactcac acatgcccac cgtgcccagc acctgaactc ctggggggac      360

cgtcagtctt cctcttcccc ccaaaaccca aggacaccct catgatctcc cggacccctg      420

aggtcacatg cgtggtggtg gacgtgagcc acgaagaccc tgaggtcaag ttcaactggt      480

acgtggacgg cgtggaggtg cataatgcca agacaaagcc gcgggaggag cagtacaaca      540

gcacgtaccg ggtggtcagc gtcctcaccg tcctgcacca ggactggctg aatggcaagg      600

agtacaagtg caaggtctcc aacaaagccc tcccagcccc catcgagaaa accatctcca      660

aagccaaagg gcagccccga gaaccacagg tgtacaccct gcccccatcc cgggatgagc      720

tgaccaagaa ccaggtcagc ctgacctgcc tggtcaaagg cttctatccc agcgacatcg      780

ccgtggagtg ggagagcaat gggcagccgg agaacaacta caagaccacg cctcccgtgc      840

tggactccga cggctccttc ttcctctaca gcaagctcac cgtggacaag agcaggtggc      900

agcaggggaa cgtcttctca tgctccgtga tgcatgaggc tctgcacaac cactacacgc      960

agaagagcct ctccctgtct ccgggtaaat ga                                    992


<210>  52
<211>  330
<212>  PRT
<213>  Homo sapiens

<220>
<223>  sIgH constant region amino acid

<400>  52

Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys 
1               5                   10                  15      


Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr 
65                  70                  75                  80  


Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      


Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys 
            100                 105                 110         


Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro 
        115                 120                 125             


Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 
    130                 135                 140                 


Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp 
145                 150                 155                 160 


Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 
                165                 170                 175     


Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 
            180                 185                 190         


His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 
        195                 200                 205             


Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 
    210                 215                 220                 


Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu 
225                 230                 235                 240 


Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr 
                245                 250                 255     


Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 
            260                 265                 270         


Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 
        275                 280                 285             


Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn 
    290                 295                 300                 


Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 
305                 310                 315                 320 


Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
                325                 330 


<210>  53
<211>  381
<212>  DNA
<213>  Homo sapiens

<220>
<223>  146B7 Vk nucleic acid

<400>  53
atggaagccc cagcgcagct tctcttcctc ctgctactct ggctcccaga taccaccgga       60

gaaattgtgt tgacgcagtc tccaggcacc ctgtctttgt ctccagggga aagagccacc      120

ctctcctgca gggccagtca gagtgttagc agcagctact tagcctggta ccagcagaaa      180

cctggccagg ctcccaggct cctcatctat ggtgcatccc gcagggccac tggcatccca      240

gacaggttca gtggcagtgg gtctgggaca gacttcactc tcaccatcag cagactggag      300

cctgaagatt ttgcagtgta ttactgtcag cggtatggta gctcacacac ttttggccag      360

gggaccaagc tggagatcaa g                                                381


<210>  54
<211>  127
<212>  PRT
<213>  Homo sapiens

<220>
<223>  146B7 Vk amino acid

<400>  54

Met Glu Ala Pro Ala Gln Leu Leu Phe Leu Leu Leu Leu Trp Leu Pro 
1               5                   10                  15      


Asp Thr Thr Gly Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Ser 
            20                  25                  30          


Leu Ser Pro Gly Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser 
        35                  40                  45              


Val Ser Ser Ser Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala 
    50                  55                  60                  


Pro Arg Leu Leu Ile Tyr Gly Ala Ser Arg Arg Ala Thr Gly Ile Pro 
65                  70                  75                  80  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile 
                85                  90                  95      


Ser Arg Leu Glu Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Arg Tyr 
            100                 105                 110         


Gly Ser Ser His Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
        115                 120                 125         


<210>  55
<211>  321
<212>  DNA
<213>  Homo sapiens

<220>
<223>  kappa constant region nucleic acid

<400>  55
actgtggctg caccatctgt cttcatcttc ccgccatctg atgagcagtt gaaatctgga       60

actgcctctg ttgtgtgcct gctgaataac ttctatccca gagaggccaa agtacagtgg      120

aaggtggata acgccctcca atcgggtaac tcccaggaga gtgtcacaga gcaggacagc      180

aaggacagca cctacagcct cagcagcacc ctgacgctga gcaaagcaga ctacgagaaa      240

cacaaagtct acgcctgcga agtcacccat cagggcctga gctcgcccgt cacaaagagc      300

ttcaacaggg gagagtgtta g                                                321


<210>  56
<211>  106
<212>  PRT
<213>  Homo sapiens

<220>
<223>  kappa constant region amino acid

<400>  56

Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln 
1               5                   10                  15      


Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr 
            20                  25                  30          


Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser 
        35                  40                  45              


Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr 
    50                  55                  60                  


Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys 
65                  70                  75                  80  


His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro 
                85                  90                  95      


Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
            100                 105     


<210>  57
<211>  417
<212>  DNA
<213>  Mus musculus

<220>
<223>  SK48E26 Vh nucleic acid

<400>  57
atgaactttg ggctcagatt gattttcctt gtccttactt taaaaggtgt gaagtgtgaa       60

gtgcacctgg tggagtctgg gggaggctta gtgaagcctg gagggtccct gaaactctcc      120

tgtgcagcct ctggattcgc tttcagtagc tatgacatgt cttgggttcg ccagactccg      180

gagaagaggc tggactgggt cgcatacatt agtagtggtg gtggtggcac ctactatcca      240

gacactgtga agggccgatt caccatctcc agggacaatg ccaagaacac cctgtacctg      300

caaatgagca gtctgaagtc tgaggacaca gccatgtatc actgtgcaag agggggggta      360

cgacgagggt acttcgatgt ctggggcgca gggaccacgg tcaccgtctc cagcgct         417


<210>  58
<211>  139
<212>  PRT
<213>  Mus musculus

<220>
<223>  SK48E26 Vh amino acid

<400>  58

Met Asn Phe Gly Leu Arg Leu Ile Phe Leu Val Leu Thr Leu Lys Gly 
1               5                   10                  15      


Val Lys Cys Glu Val His Leu Val Glu Ser Gly Gly Gly Leu Val Lys 
            20                  25                  30          


Pro Gly Gly Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Ala Phe 
        35                  40                  45              


Ser Ser Tyr Asp Met Ser Trp Val Arg Gln Thr Pro Glu Lys Arg Leu 
    50                  55                  60                  


Asp Trp Val Ala Tyr Ile Ser Ser Gly Gly Gly Gly Thr Tyr Tyr Pro 
65                  70                  75                  80  


Asp Thr Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn 
                85                  90                  95      


Thr Leu Tyr Leu Gln Met Ser Ser Leu Lys Ser Glu Asp Thr Ala Met 
            100                 105                 110         


Tyr His Cys Ala Arg Gly Gly Val Arg Arg Gly Tyr Phe Asp Val Trp 
        115                 120                 125             


Gly Ala Gly Thr Thr Val Thr Val Ser Ser Ala 
    130                 135                 


<210>  59
<211>  381
<212>  DNA
<213>  Mus musculus

<220>
<223>  SK48E26 Vk nucleic acid

<400>  59
atgagtgtgc tcactcaggt cctggcgttg ctgctgctgt ggcttacagg tgccagatgt       60

gacatccaga tgactcagtc tccagcctcc ctatctgcat ctgtgggaga aactgtcacc      120

atcacatgtc gagcaagtgg gaatattcac aattatttaa catggtatca gcagaaacag      180

ggaaaatctc ctcagctcct ggtctataat gcaaaaacct tagcagatgg tgtgccgtca      240

aggttcagtg gcagtggatc aggaacacaa tattctctca agatcaacag cctgcagcct      300

gaagattttg ggagttatta ctgtcaacat ttttggagta ttccgtacac gttcggaggg      360

gggaccaagc tggaaataaa g                                                381


<210>  60
<211>  127
<212>  PRT
<213>  Mus musculus

<220>
<223>  SK48E26 Vk amino acid

<400>  60

Met Ser Val Leu Thr Gln Val Leu Ala Leu Leu Leu Leu Trp Leu Thr 
1               5                   10                  15      


Gly Ala Arg Cys Asp Ile Gln Met Thr Gln Ser Pro Ala Ser Leu Ser 
            20                  25                  30          


Ala Ser Val Gly Glu Thr Val Thr Ile Thr Cys Arg Ala Ser Gly Asn 
        35                  40                  45              


Ile His Asn Tyr Leu Thr Trp Tyr Gln Gln Lys Gln Gly Lys Ser Pro 
    50                  55                  60                  


Gln Leu Leu Val Tyr Asn Ala Lys Thr Leu Ala Asp Gly Val Pro Ser 
65                  70                  75                  80  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Gln Tyr Ser Leu Lys Ile Asn 
                85                  90                  95      


Ser Leu Gln Pro Glu Asp Phe Gly Ser Tyr Tyr Cys Gln His Phe Trp 
            100                 105                 110         


Ser Ile Pro Tyr Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
        115                 120                 125         


<210>  61
<211>  42
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Forward primer murine bcl2A

<400>  61
attgctagca tggcgcaagc cgggagaaca gggtatgata ac                          42


<210>  62
<211>  39
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Reverse primer murine bcl2A

<400>  62
cgcacgcgtc acttgtggcc caggtatgca cccagagtg                              39


<210>  63
<211>  708
<212>  DNA
<213>  Mus musculus

<220>
<223>  bcl2A nucleic acid

<400>  63
atggcgcacg ctgggcgaac agggtatgat aaccgggaga tcgtgatgaa gtacatacat       60

tataagctgt cacagagggg ctacgagtgg gatgctggag atgcggacgc ggcgcccctg      120

ggggctgccc ccacccctgg catcttctcc ttccagcctg agagcaaccc aatgcctgct      180

gtgcaccggg acatggctgc caggacgtct cctctcaggc ccctcgttgc caccgctggg      240

cctgcgctca gccctgtgcc acctgtggtc catctgaccc tccgccgggc tggggatgac      300

ttctctcgtc gctaccgtcg tgacttcgca gagatgtcca gtcagctgca cctgacgccc      360

ttcaccgcga ggggacgctt tgccacggtg gtggaggaac tcttcaggga tggggtgaac      420

tgggggagga ttgtggcctt ctttgagttc ggtggggtca tgtgtgtgga gagcgtcaac      480

agggagatgt cacccctggt ggacaacatc gccctgtgga tgactgagta cctgaaccgg      540

catctgcaca cctggatcca ggataacgga ggctgggatg cctttgtgga actatatggc      600

cccagcatgc gacctctgtt tgatttctcc tggctgtctc tgaagaccct gctcagcctg      660

gccctggtcg gggcctgcat cactctgggt gcctatctga gccacaag                   708


<210>  64
<211>  639
<212>  DNA
<213>  Homo sapiens

<220>
<223>  IL-6 nucleic acid

<400>  64
atgaactcct tctccacaag cgccttcggt ccagttgcct tctccctggg gctgctcctg       60

gtgttgcctg ctgccttccc tgccccagta cccccaggag aagattccaa agatgtagcc      120

gccccacaca gacagccact cacctcttca gaacgaattg acaaacaaat tcggtacatc      180

ctcgacggca tctcagccct gagaaaggag acatgtaaca agagtaacat gtgtgaaagc      240

agcaaagagg cactggcaga aaacaacctg aaccttccaa agatggctga aaaagatgga      300

tgcttccaat ctggattcaa tgaggagact tgcctggtga aaatcatcac tggtcttttg      360

gagtttgagg tatacctaga gtacctccag aacagatttg agagtagtga ggaacaagcc      420

agagctgtgc agatgagtac aaaagtcctg atccagttcc tgcagaaaaa ggcaaagaat      480

ctagatgcaa taaccacccc tgacccaacc acaaatgcca gcctgctgac gaagctgcag      540

gcacagaacc agtggctgca ggacatgaca actcatctca ttctgcgcag ctttaaggag      600

ttcctgcagt ccagcctgag ggctcttcgg caaatgtag                             639


<210>  65
<211>  702
<212>  DNA
<213>  Homo sapiens

<220>
<223>  TNFalpha nucleic acid

<400>  65
atgagcactg aaagcatgat ccgggacgtg gagctggccg aggaggcgct ccccaagaag       60

acaggggggc cccagggctc caggcggtgc ttgttcctca gcctcttctc cttcctgatc      120

gtggcaggcg ccaccacgct cttctgcctg ctgcactttg gagtgatcgg cccccagagg      180

gaagagttcc ccagggacct ctctctaatc agccctctgg cccaggcagt cagatcatct      240

tctcgaaccc cgagtgacaa gcctgtagcc catgttgtag caaaccctca agctgagggg      300

cagctccagt ggctgaaccg ccgggccaat gccctcctgg ccaatggcgt ggagctgaga      360

gataaccagc tggtggtgcc atcagagggc ctgtacctca tctactccca ggtcctcttc      420

aagggccaag gctgcccctc cacccatgtg ctcctcaccc acaccatcag ccgcatcgcc      480

gtctcctacc agaccaaggt caacctcctc tctgccatca agagcccctg ccagagggag      540

accccagagg gggctgaggc caagccctgg tatgagccca tctatctggg aggggtcttc      600

cagctggaga agggtgaccg actcagcgct gagatcaatc ggcccgacta tctcgacttt      660

gccgagtctg ggcaggtcta ctttgggatc attgccctgt ga                         702


<210>  66
<211>  276
<212>  DNA
<213>  Homo sapiens

<220>
<223>  CCL5 nucleic acid

<400>  66
atgaaggtct ccgcggcagc cctcgctgtc atcctcattg ctactgccct ctgcgctcct       60

gcatctgcct ccccatattc ctcggacacc acaccctgct gctttgccta cattgcccgc      120

ccactgcccc gtgcccacat caaggagtat ttctacacca gtggcaagtg ctccaaccca      180

gcagtcgtct ttgtcacccg aaagaaccgc caagtgtgtg ccaacccaga gaagaaatgg      240

gttcgggagt acatcaactc tttggagatg agctag                                276


