                         SEQUENCE LISTING

<110>  University of Maryland, Baltimore
 
<120>  Multivalent Live Vector Vaccine against Clostridium 
       difficile-Associated Disease

<130>  UMB-011PCT1

<150>  US 61/261,406
<151>  2009-11-09

<160>  19    

<170>  PatentIn version 3.5

<210>  1
<211>  996
<212>  DNA
<213>  artificial

<220>
<223>  synthetic

<400>  1
tagtaatgaa tggctagcac cggctatacg agcatcaacg ggaagcattt ttatttcaat       60

accgacggca ttatgcagat cggggtgttc aaagggccca acggtttcga atactttgcg      120

ccggccaaca cggatgcgaa taacatcgaa ggtcaagcca tcctctacca gaacaaattc      180

ctgaccctca atggcaagaa atattacttc gggtccgaca gcaaggctgt cacgggtctg      240

cgcacgattg atgggaaaaa gtattacttc aacaccaata ctgccgtggc ggtcaccgga      300

tggcaaacga tcaacggcaa gaaatactac ttcaatacca acacgtccat tgcctcgacc      360

gggtatacga tcatttccgg caaacacttc tacttcaaca ccgacgggat catgcaaatc      420

ggtgtgttta aagggcccga tggcttcgag tactttgccc cggcgaatac ggacgccaat      480

aacattgaag gtcaggcaat tcggtatcag aatcgttttc tctatctgca tgacaacatc      540

tactatttcg gtaataacag caaggcggcc accgggtggg tcacgattga tggcaaccgg      600

tattacttcg agcccaatac ggcgatgggg gcgaatggtt ataaaacgat cgacaacaag      660

aatttctact ttcgcaacgg gctcccgcag attggcgtgt tcaaagggtc caacggcttt      720

gagtacttcg cccccgcgaa tacggatgcc aacaatatcg agggccaagc gattcggtat      780

caaaaccgct tcctccacct gctcgggaaa atctattact tcggcaataa ctcgaaagcc      840

gtcacgggtt ggcaaacgat taatggcaaa gtgtattact tcatgccgga tactgcaatg      900

gcagccgctg gtggattatt cgaaattgac ggcgtcatct atttctttgg cgtggatggg      960

gtcaaagccc cggggatcta tggctaatga cctagg                                996


<210>  2
<211>  325
<212>  PRT
<213>  artificial

<220>
<223>  synthetic

<400>  2

Met Ala Ser Thr Gly Tyr Thr Ser Ile Asn Gly Lys His Phe Tyr Phe 
1               5                   10                  15      


Asn Thr Asp Gly Ile Met Gln Ile Gly Val Phe Lys Gly Pro Asn Gly 
            20                  25                  30          


Phe Glu Tyr Phe Ala Pro Ala Asn Thr Asp Ala Asn Asn Ile Glu Gly 
        35                  40                  45              


Gln Ala Ile Leu Tyr Gln Asn Lys Phe Leu Thr Leu Asn Gly Lys Lys 
    50                  55                  60                  


Tyr Tyr Phe Gly Ser Asp Ser Lys Ala Val Thr Gly Leu Arg Thr Ile 
65                  70                  75                  80  


Asp Gly Lys Lys Tyr Tyr Phe Asn Thr Asn Thr Ala Val Ala Val Thr 
                85                  90                  95      


Gly Trp Gln Thr Ile Asn Gly Lys Lys Tyr Tyr Phe Asn Thr Asn Thr 
            100                 105                 110         


Ser Ile Ala Ser Thr Gly Tyr Thr Ile Ile Ser Gly Lys His Phe Tyr 
        115                 120                 125             


Phe Asn Thr Asp Gly Ile Met Gln Ile Gly Val Phe Lys Gly Pro Asp 
    130                 135                 140                 


Gly Phe Glu Tyr Phe Ala Pro Ala Asn Thr Asp Ala Asn Asn Ile Glu 
145                 150                 155                 160 


Gly Gln Ala Ile Arg Tyr Gln Asn Arg Phe Leu Tyr Leu His Asp Asn 
                165                 170                 175     


Ile Tyr Tyr Phe Gly Asn Asn Ser Lys Ala Ala Thr Gly Trp Val Thr 
            180                 185                 190         


Ile Asp Gly Asn Arg Tyr Tyr Phe Glu Pro Asn Thr Ala Met Gly Ala 
        195                 200                 205             


Asn Gly Tyr Lys Thr Ile Asp Asn Lys Asn Phe Tyr Phe Arg Asn Gly 
    210                 215                 220                 


Leu Pro Gln Ile Gly Val Phe Lys Gly Ser Asn Gly Phe Glu Tyr Phe 
225                 230                 235                 240 


Ala Pro Ala Asn Thr Asp Ala Asn Asn Ile Glu Gly Gln Ala Ile Arg 
                245                 250                 255     


Tyr Gln Asn Arg Phe Leu His Leu Leu Gly Lys Ile Tyr Tyr Phe Gly 
            260                 265                 270         


Asn Asn Ser Lys Ala Val Thr Gly Trp Gln Thr Ile Asn Gly Lys Val 
        275                 280                 285             


Tyr Tyr Phe Met Pro Asp Thr Ala Met Ala Ala Ala Gly Gly Leu Phe 
    290                 295                 300                 


Glu Ile Asp Gly Val Ile Tyr Phe Phe Gly Val Asp Gly Val Lys Ala 
305                 310                 315                 320 


Pro Gly Ile Tyr Gly 
                325 


<210>  3
<211>  1629
<212>  DNA
<213>  artificial

<220>
<223>  synthetic

<400>  3
tagtaatgaa tggctagcgg cctgatctat attaacgatt cactgtacta tttcaagccg       60

cccgtcaata acctcatcac cgggtttgtg acggtcggcg acgataaata ctacttcaat      120

ccgatcaacg gcggagccgc gagcattggg gagaccatca ttgatgacaa gaattattac      180

ttcaaccaga gtggcgtgct gcagacgggg gtcttcagta ccgaggacgg ctttaaatac      240

ttcgcccccg cgaatacgct cgatgagaac ctggaagggg aggcgattga ctttaccggc      300

aagctgatca ttgacgagaa catctactat ttcgatgaca attaccgcgg ggccgtggaa      360

tggaaggagc tcgatggcga gatgcactat tttagcccgg agacggggaa agctttcaaa      420

ggcctgaatc aaattgggga ctacaagtat tacttcaact ctgacggtgt gatgcagaag      480

gggttcgtga gtatcaatga caacaagcat tatttcgacg attctggcgt catgaaagtg      540

gggtacaccg agatcgatgg caagcacttc tactttgccg agaatggtga gatgcaaatc      600

ggcgtgttca atacggaaga cgggtttaag tatttcgcgc atcataacga ggatctcggc      660

aatgaagagg gcgaagagat ctcatattcc ggaatcctca acttcaataa caagatttac      720

tactttgatg actcatttac cgccgtggtc ggctggaagg acctcgagga tgggtcaaag      780

tactatttcg acgaggatac ggcggaggcc tacatcggcc tgtcattaat caacgacggc      840

cagtattact ttaatgatga cggcatcatg caggtcgggt ttgtcaccat caacgataaa      900

gtcttctact tctctgactc tggcattatc gagagcgggg tgcagaacat cgacgataac      960

tatttctaca tcgatgacaa tggcattgtc cagatcggcg tgttcgatac gtcagacggt     1020

tataagtatt ttgcgcccgc caacaccgtc aacgataata tctacggtca agctgttgaa     1080

tatagtggtt tggtccgtgt cggtgaagac gtgtactatt tcggcgagac gtacacaatt     1140

gagacgggct ggatctatga tatggagaac gagagtgaca agtactattt caatcctgag     1200

accaagaaag catgcaaggg gatcaacctg atcgatgaca tcaagtacta tttcgacgag     1260

aagggcatta tgcgcacggg gcttatctca tttgagaata acaattatta cttcaatgag     1320

aacggggaaa tgcagtttgg gtacatcaat attgaggaca agatgttcta ttttggcgag     1380

gatggcgtca tgcagatcgg ggtgttcaac accccagatg gtttcaagta tttcgcgcat     1440

cagaatacgc tggatgagaa cttcgagggc gaatcaatca actataccgg gtggctggac     1500

ctcgatgaga agcgctacta tttcacggac gaatacattg cggccaccgg ctcagtcatc     1560

attgatggcg aggaatacta tttcgaccct gatacggcgc agctggtgat cagtgagtaa     1620

tgacctagg                                                             1629


<210>  4
<211>  536
<212>  PRT
<213>  artificial

<220>
<223>  synthetic

<400>  4

Met Ala Ser Gly Leu Ile Tyr Ile Asn Asp Ser Leu Tyr Tyr Phe Lys 
1               5                   10                  15      


Pro Pro Val Asn Asn Leu Ile Thr Gly Phe Val Thr Val Gly Asp Asp 
            20                  25                  30          


Lys Tyr Tyr Phe Asn Pro Ile Asn Gly Gly Ala Ala Ser Ile Gly Glu 
        35                  40                  45              


Thr Ile Ile Asp Asp Lys Asn Tyr Tyr Phe Asn Gln Ser Gly Val Leu 
    50                  55                  60                  


Gln Thr Gly Val Phe Ser Thr Glu Asp Gly Phe Lys Tyr Phe Ala Pro 
65                  70                  75                  80  


Ala Asn Thr Leu Asp Glu Asn Leu Glu Gly Glu Ala Ile Asp Phe Thr 
                85                  90                  95      


Gly Lys Leu Ile Ile Asp Glu Asn Ile Tyr Tyr Phe Asp Asp Asn Tyr 
            100                 105                 110         


Arg Gly Ala Val Glu Trp Lys Glu Leu Asp Gly Glu Met His Tyr Phe 
        115                 120                 125             


Ser Pro Glu Thr Gly Lys Ala Phe Lys Gly Leu Asn Gln Ile Gly Asp 
    130                 135                 140                 


Tyr Lys Tyr Tyr Phe Asn Ser Asp Gly Val Met Gln Lys Gly Phe Val 
145                 150                 155                 160 


Ser Ile Asn Asp Asn Lys His Tyr Phe Asp Asp Ser Gly Val Met Lys 
                165                 170                 175     


Val Gly Tyr Thr Glu Ile Asp Gly Lys His Phe Tyr Phe Ala Glu Asn 
            180                 185                 190         


Gly Glu Met Gln Ile Gly Val Phe Asn Thr Glu Asp Gly Phe Lys Tyr 
        195                 200                 205             


Phe Ala His His Asn Glu Asp Leu Gly Asn Glu Glu Gly Glu Glu Ile 
    210                 215                 220                 


Ser Tyr Ser Gly Ile Leu Asn Phe Asn Asn Lys Ile Tyr Tyr Phe Asp 
225                 230                 235                 240 


Asp Ser Phe Thr Ala Val Val Gly Trp Lys Asp Leu Glu Asp Gly Ser 
                245                 250                 255     


Lys Tyr Tyr Phe Asp Glu Asp Thr Ala Glu Ala Tyr Ile Gly Leu Ser 
            260                 265                 270         


Leu Ile Asn Asp Gly Gln Tyr Tyr Phe Asn Asp Asp Gly Ile Met Gln 
        275                 280                 285             


Val Gly Phe Val Thr Ile Asn Asp Lys Val Phe Tyr Phe Ser Asp Ser 
    290                 295                 300                 


Gly Ile Ile Glu Ser Gly Val Gln Asn Ile Asp Asp Asn Tyr Phe Tyr 
305                 310                 315                 320 


Ile Asp Asp Asn Gly Ile Val Gln Ile Gly Val Phe Asp Thr Ser Asp 
                325                 330                 335     


Gly Tyr Lys Tyr Phe Ala Pro Ala Asn Thr Val Asn Asp Asn Ile Tyr 
            340                 345                 350         


Gly Gln Ala Val Glu Tyr Ser Gly Leu Val Arg Val Gly Glu Asp Val 
        355                 360                 365             


Tyr Tyr Phe Gly Glu Thr Tyr Thr Ile Glu Thr Gly Trp Ile Tyr Asp 
    370                 375                 380                 


Met Glu Asn Glu Ser Asp Lys Tyr Tyr Phe Asn Pro Glu Thr Lys Lys 
385                 390                 395                 400 


Ala Cys Lys Gly Ile Asn Leu Ile Asp Asp Ile Lys Tyr Tyr Phe Asp 
                405                 410                 415     


Glu Lys Gly Ile Met Arg Thr Gly Leu Ile Ser Phe Glu Asn Asn Asn 
            420                 425                 430         


Tyr Tyr Phe Asn Glu Asn Gly Glu Met Gln Phe Gly Tyr Ile Asn Ile 
        435                 440                 445             


Glu Asp Lys Met Phe Tyr Phe Gly Glu Asp Gly Val Met Gln Ile Gly 
    450                 455                 460                 


Val Phe Asn Thr Pro Asp Gly Phe Lys Tyr Phe Ala His Gln Asn Thr 
465                 470                 475                 480 


Leu Asp Glu Asn Phe Glu Gly Glu Ser Ile Asn Tyr Thr Gly Trp Leu 
                485                 490                 495     


Asp Leu Asp Glu Lys Arg Tyr Tyr Phe Thr Asp Glu Tyr Ile Ala Ala 
            500                 505                 510         


Thr Gly Ser Val Ile Ile Asp Gly Glu Glu Tyr Tyr Phe Asp Pro Asp 
        515                 520                 525             


Thr Ala Gln Leu Val Ile Ser Glu 
    530                 535     


<210>  5
<211>  2655
<212>  DNA
<213>  artificial

<220>
<223>  synthetic

<400>  5
tagtaatgaa tggctagcaa aatccagatg cgtaacaaaa aagttctgag ttttctgacc       60

ctgacggcga tcgtgagcca ggccctggtt tatccggtgt acgcgcagac ctctacgagt      120

aaccatagca acaagaaaaa agaaatcgtg aacgaagata tcctgccgaa caatggcctg      180

atgggttatt actttaccga tgaacacttc aaagacctga aactgatggc gccgattaaa      240

gatggcaacc tgaaattcga agagaaaaaa gttgataaac tgctggataa agataaaagc      300

gatgtgaaat ctatccgttg gaccggtcgc attatcccga gcaaagatgg cgaatatacc      360

ctgtctacgg atcgtgatga tgttctgatg caagtgaata ccgaaagcac gatctctaac      420

accctgaaag ttaacatgaa aaagggtaaa gaatacaaag tgcgcatcga actgcaggat      480

aaaaacctgg gctctatcga taatctgagc tctccgaacc tgtattggga actggatggt      540

atgaagaaaa ttatcccgga agaaaatctg tttctgcgtg attacagcaa cattgaaaaa      600

gatgatccgt tcatcccgaa caataacttt ttcgatccga aactgatgtc tgattgggaa      660

gatgaagacc tggataccga taatgataac attccggata gttatgaacg caatggttac      720

accatcaaag acctgattgc ggttaaatgg gaagatagct ttgccgaaca gggctacaaa      780

aaatacgtga gcaactacct ggaatctaac accgccggtg atccgtatac ggattacgaa      840

aaagcaagcg gctctttcga taaagcaatt aaaaccgaag cgcgtgatcc gctggttgcg      900

gcctatccga tcgtgggcgt tggtatggaa aaactgatta tctctaccaa cgaacatgcg      960

agtaccgatc agggtaaaac cgtgagtcgc gccaccacga atagtaaaac cgaaagcaac     1020

acggcaggcg tgagcgttaa tgtgggctat cagaacggtt ttaccgcgaa tgttaccacg     1080

aactacagcc acaccacgga taattctacc gccgtgcagg attctaatgg cgaaagttgg     1140

aacacgggtc tgagtattaa caaaggcgaa agcgcctaca tcaacgcaaa cgttcgttac     1200

tacaacaccg gtacggcccc gatgtacaaa gttaccccga ccacgaacct ggtgctggat     1260

ggcgataccc tgagcacgat taaagcacag gaaaaccaga tcggtaataa cctgtctccg     1320

ggcgatacct atccgaaaaa aggtctgagt ccgctggcgc tgaataccat ggatcagttt     1380

agtagccgcc tgattccgat caactacgat cagctgaaaa aactggatgc cggcaaacag     1440

attaaactgg aaaccacgca agttagcggc aatttcggta ccaaaaactc tagtggtcag     1500

atcgtgacgg aaggcaatag ttggagcgat tatattagcc agatcgattc tattagtgca     1560

agcattatcc tggataccga aaatgaatct tacgaacgtc gcgtgacggc gaaaaacctg     1620

caagatccgg aagataaaac cccggaactg acgatcggtg aagccattga aaaagcattt     1680

ggtgcgacca aaaaagatgg cctgctgtat ttcaacgata ttccgatcga tgaaagctgc     1740

gttgaactga tcttcgatga taacaccgca aacaaaatca aagatagtct gaaaacgctg     1800

agcgataaga aaatttataa cgtgaaactg gaacgtggca tgaacattct gatcaaaacc     1860

ccgacgtact tcaccaactt cgatgattac aacaactacc cgagtacgtg gagcaatgtt     1920

aacaccacga accaggatgg cctgcagggt agcgccaaca aactgaacgg tgaaaccaaa     1980

atcaaaatcc cgatgtctga actgaaaccg tataaacgct acgtgttttc tggctatagt     2040

aaagatccgc tgacctctaa tagtatcatc gttaaaatca aagcgaaaga agaaaaaacc     2100

gattacctgg tgccggaaca gggttacacg aaattcagtt acgaatttga aaccacggaa     2160

aaagatagct ctaacattga aatcaccctg attggcagcg gtaccacgta tctggataat     2220

ctgtctatta ccgaactgaa cagtacgccg gaaatcctgg atgaaccgga agtgaaaatc     2280

ccgaccgatc aggaaatcat ggatgcccat aaaatctatt tcgcggatct gaacttcaac     2340

ccgagcaccg gtaatacgta tattaacggc atgtactttg caccgaccca gacgaataaa     2400

gaagcgctgg attatattca gaaataccgt gttgaagcca ccctgcagta tagcggcttc     2460

aaagatatcg gtacgaaaga taaagaaatg cgtaattacc tgggcgatcc gaaccagccg     2520

aaaaccaatt atgtgaacct gcgctcttac tttaccggcg gtgaaaacat catgacgtac     2580

aaaaaactgc gtatctacgc gattaccccg gatgatcgcg aactgctggt tctgagtgtg     2640

gattaataac ctagg                                                      2655


<210>  6
<211>  878
<212>  PRT
<213>  artificial

<220>
<223>  synthetic

<400>  6

Met Ala Ser Lys Ile Gln Met Arg Asn Lys Lys Val Leu Ser Phe Leu 
1               5                   10                  15      


Thr Leu Thr Ala Ile Val Ser Gln Ala Leu Val Tyr Pro Val Tyr Ala 
            20                  25                  30          


Gln Thr Ser Thr Ser Asn His Ser Asn Lys Lys Lys Glu Ile Val Asn 
        35                  40                  45              


Glu Asp Ile Leu Pro Asn Asn Gly Leu Met Gly Tyr Tyr Phe Thr Asp 
    50                  55                  60                  


Glu His Phe Lys Asp Leu Lys Leu Met Ala Pro Ile Lys Asp Gly Asn 
65                  70                  75                  80  


Leu Lys Phe Glu Glu Lys Lys Val Asp Lys Leu Leu Asp Lys Asp Lys 
                85                  90                  95      


Ser Asp Val Lys Ser Ile Arg Trp Thr Gly Arg Ile Ile Pro Ser Lys 
            100                 105                 110         


Asp Gly Glu Tyr Thr Leu Ser Thr Asp Arg Asp Asp Val Leu Met Gln 
        115                 120                 125             


Val Asn Thr Glu Ser Thr Ile Ser Asn Thr Leu Lys Val Asn Met Lys 
    130                 135                 140                 


Lys Gly Lys Glu Tyr Lys Val Arg Ile Glu Leu Gln Asp Lys Asn Leu 
145                 150                 155                 160 


Gly Ser Ile Asp Asn Leu Ser Ser Pro Asn Leu Tyr Trp Glu Leu Asp 
                165                 170                 175     


Gly Met Lys Lys Ile Ile Pro Glu Glu Asn Leu Phe Leu Arg Asp Tyr 
            180                 185                 190         


Ser Asn Ile Glu Lys Asp Asp Pro Phe Ile Pro Asn Asn Asn Phe Phe 
        195                 200                 205             


Asp Pro Lys Leu Met Ser Asp Trp Glu Asp Glu Asp Leu Asp Thr Asp 
    210                 215                 220                 


Asn Asp Asn Ile Pro Asp Ser Tyr Glu Arg Asn Gly Tyr Thr Ile Lys 
225                 230                 235                 240 


Asp Leu Ile Ala Val Lys Trp Glu Asp Ser Phe Ala Glu Gln Gly Tyr 
                245                 250                 255     


Lys Lys Tyr Val Ser Asn Tyr Leu Glu Ser Asn Thr Ala Gly Asp Pro 
            260                 265                 270         


Tyr Thr Asp Tyr Glu Lys Ala Ser Gly Ser Phe Asp Lys Ala Ile Lys 
        275                 280                 285             


Thr Glu Ala Arg Asp Pro Leu Val Ala Ala Tyr Pro Ile Val Gly Val 
    290                 295                 300                 


Gly Met Glu Lys Leu Ile Ile Ser Thr Asn Glu His Ala Ser Thr Asp 
305                 310                 315                 320 


Gln Gly Lys Thr Val Ser Arg Ala Thr Thr Asn Ser Lys Thr Glu Ser 
                325                 330                 335     


Asn Thr Ala Gly Val Ser Val Asn Val Gly Tyr Gln Asn Gly Phe Thr 
            340                 345                 350         


Ala Asn Val Thr Thr Asn Tyr Ser His Thr Thr Asp Asn Ser Thr Ala 
        355                 360                 365             


Val Gln Asp Ser Asn Gly Glu Ser Trp Asn Thr Gly Leu Ser Ile Asn 
    370                 375                 380                 


Lys Gly Glu Ser Ala Tyr Ile Asn Ala Asn Val Arg Tyr Tyr Asn Thr 
385                 390                 395                 400 


Gly Thr Ala Pro Met Tyr Lys Val Thr Pro Thr Thr Asn Leu Val Leu 
                405                 410                 415     


Asp Gly Asp Thr Leu Ser Thr Ile Lys Ala Gln Glu Asn Gln Ile Gly 
            420                 425                 430         


Asn Asn Leu Ser Pro Gly Asp Thr Tyr Pro Lys Lys Gly Leu Ser Pro 
        435                 440                 445             


Leu Ala Leu Asn Thr Met Asp Gln Phe Ser Ser Arg Leu Ile Pro Ile 
    450                 455                 460                 


Asn Tyr Asp Gln Leu Lys Lys Leu Asp Ala Gly Lys Gln Ile Lys Leu 
465                 470                 475                 480 


Glu Thr Thr Gln Val Ser Gly Asn Phe Gly Thr Lys Asn Ser Ser Gly 
                485                 490                 495     


Gln Ile Val Thr Glu Gly Asn Ser Trp Ser Asp Tyr Ile Ser Gln Ile 
            500                 505                 510         


Asp Ser Ile Ser Ala Ser Ile Ile Leu Asp Thr Glu Asn Glu Ser Tyr 
        515                 520                 525             


Glu Arg Arg Val Thr Ala Lys Asn Leu Gln Asp Pro Glu Asp Lys Thr 
    530                 535                 540                 


Pro Glu Leu Thr Ile Gly Glu Ala Ile Glu Lys Ala Phe Gly Ala Thr 
545                 550                 555                 560 


Lys Lys Asp Gly Leu Leu Tyr Phe Asn Asp Ile Pro Ile Asp Glu Ser 
                565                 570                 575     


Cys Val Glu Leu Ile Phe Asp Asp Asn Thr Ala Asn Lys Ile Lys Asp 
            580                 585                 590         


Ser Leu Lys Thr Leu Ser Asp Lys Lys Ile Tyr Asn Val Lys Leu Glu 
        595                 600                 605             


Arg Gly Met Asn Ile Leu Ile Lys Thr Pro Thr Tyr Phe Thr Asn Phe 
    610                 615                 620                 


Asp Asp Tyr Asn Asn Tyr Pro Ser Thr Trp Ser Asn Val Asn Thr Thr 
625                 630                 635                 640 


Asn Gln Asp Gly Leu Gln Gly Ser Ala Asn Lys Leu Asn Gly Glu Thr 
                645                 650                 655     


Lys Ile Lys Ile Pro Met Ser Glu Leu Lys Pro Tyr Lys Arg Tyr Val 
            660                 665                 670         


Phe Ser Gly Tyr Ser Lys Asp Pro Leu Thr Ser Asn Ser Ile Ile Val 
        675                 680                 685             


Lys Ile Lys Ala Lys Glu Glu Lys Thr Asp Tyr Leu Val Pro Glu Gln 
    690                 695                 700                 


Gly Tyr Thr Lys Phe Ser Tyr Glu Phe Glu Thr Thr Glu Lys Asp Ser 
705                 710                 715                 720 


Ser Asn Ile Glu Ile Thr Leu Ile Gly Ser Gly Thr Thr Tyr Leu Asp 
                725                 730                 735     


Asn Leu Ser Ile Thr Glu Leu Asn Ser Thr Pro Glu Ile Leu Asp Glu 
            740                 745                 750         


Pro Glu Val Lys Ile Pro Thr Asp Gln Glu Ile Met Asp Ala His Lys 
        755                 760                 765             


Ile Tyr Phe Ala Asp Leu Asn Phe Asn Pro Ser Thr Gly Asn Thr Tyr 
    770                 775                 780                 


Ile Asn Gly Met Tyr Phe Ala Pro Thr Gln Thr Asn Lys Glu Ala Leu 
785                 790                 795                 800 


Asp Tyr Ile Gln Lys Tyr Arg Val Glu Ala Thr Leu Gln Tyr Ser Gly 
                805                 810                 815     


Phe Lys Asp Ile Gly Thr Lys Asp Lys Glu Met Arg Asn Tyr Leu Gly 
            820                 825                 830         


Asp Pro Asn Gln Pro Lys Thr Asn Tyr Val Asn Leu Arg Ser Tyr Phe 
        835                 840                 845             


Thr Gly Gly Glu Asn Ile Met Thr Tyr Lys Lys Leu Arg Ile Tyr Ala 
    850                 855                 860                 


Ile Thr Pro Asp Asp Arg Glu Leu Leu Val Leu Ser Val Asp 
865                 870                 875             


<210>  7
<211>  8045
<212>  DNA
<213>  artificial

<220>
<223>  synthetic

<400>  7
gaattctgtg gtagcacaga ataatgaaaa gtgtgtaaag aagggtaaaa aaaaccgaat       60

gcgaggcatc cggttgaaat aggggtaaac agacattcag aaatgaatga cggtaataaa      120

taaagttaat gatgatagcg ggagttattc tagttgcgag tgaaggtttt gttttgacat      180

tcagtgctgt caaatactta agaataagtt attgatttta accttgaatt attattgctt      240

gatgttaggt gcttatttcg ccattccgca ataatcttaa aaagttccct tgcatttaca      300

ttttgaaaca tctatagcga taaatgaaac atcttaaaag ttttagtatc atattcgtgt      360

tggattattc tgcatttttg gggagaatgg acttgccgac tgattaatga gggttaatca      420

gtatgcagtg gcataaaaaa gcaaataaag gcatataaca gatcgatctt aaacatccac      480

aggaggatgg gatccaaaat aaggaggaaa aaaaaatgac tagtattttt gcagaacaaa      540

ctgtagaggt agttaaaagc gcgatcgaaa ccgcagatgg ggcattagat ctttataaca      600

aatacctcga ccaggtcatc ccctggaaga cctttgatga aaccataaaa gagttaagcc      660

gttttaaaca ggagtactcg caggaagctt ctgttttagt tggtgatatt aaagttttgc      720

ttatggacag ccaggacaag tattttgaag cgacacaaac tgtttatgaa tggtgtggtg      780

tcgtgacgca attactctca gcgtatattt tactatttga tgaatataat gagaaaaaag      840

catcagccca gaaagacatt ctcattagga tattagatga tggtgtcaag aaactgaatg      900

aagcgcaaaa atctctcctg acaagttcac aaagtttcaa caacgcttcc ggaaaactgc      960

tggcattaga tagccagtta actaatgatt tttcggaaaa aagtagttat ttccagtcac     1020

aggtggatag aattcgtaag gaagcttatg ccggtgctgc agccggcata gtcgccggtc     1080

cgtttggatt aattatttcc tattctattg ctgcgggcgt gattgaaggg aaattgattc     1140

cagaattgaa taacaggcta aaaacagtgc aaaatttctt tactagctta tcagctacag     1200

tgaaacaagc gaataaagat atcgatgcgg caaaattgaa attagccact gaaatagcag     1260

caattgggga gataaaaacg gaaaccgaaa caaccagatt ctacgttgat tatgatgatt     1320

taatgctttc tttattaaaa ggagctgcaa agaaaatgat taacacctgt aatgaatacc     1380

aacaacgtca tggtaagaag acgcttttcg aggttcctga cgtcgctagc ggcctgatct     1440

atattaacga ttcactgtac tatttcaagc cgcccgtcaa taacctcatc accgggtttg     1500

tgacggtcgg cgacgataaa tactacttca atccgatcaa cggcggagcc gcgagcattg     1560

gggagaccat cattgatgac aagaattatt acttcaacca gagtggcgtg ctgcagacgg     1620

gggtcttcag taccgaggac ggctttaaat acttcgcccc cgcgaatacg ctcgatgaga     1680

acctggaagg ggaggcgatt gactttaccg gcaagctgat cattgacgag aacatctact     1740

atttcgatga caattaccgc ggggccgtgg aatggaagga gctcgatggc gagatgcact     1800

attttagccc ggagacgggg aaagctttca aaggcctgaa tcaaattggg gactacaagt     1860

attacttcaa ctctgacggt gtgatgcaga aggggttcgt gagtatcaat gacaacaagc     1920

attatttcga cgattctggc gtcatgaaag tggggtacac cgagatcgat ggcaagcact     1980

tctactttgc cgagaatggt gagatgcaaa tcggcgtgtt caatacggaa gacgggttta     2040

agtatttcgc gcatcataac gaggatctcg gcaatgaaga gggcgaagag atctcatatt     2100

ccggaatcct caacttcaat aacaagattt actactttga tgactcattt accgccgtgg     2160

tcggctggaa ggacctcgag gatgggtcaa agtactattt cgacgaggat acggcggagg     2220

cctacatcgg cctgtcatta atcaacgacg gccagtatta ctttaatgat gacggcatca     2280

tgcaggtcgg gtttgtcacc atcaacgata aagtcttcta cttctctgac tctggcatta     2340

tcgagagcgg ggtgcagaac atcgacgata actatttcta catcgatgac aatggcattg     2400

tccagatcgg cgtgttcgat acgtcagacg gttataagta ttttgcgccc gccaacaccg     2460

tcaacgataa tatctacggt caagctgttg aatatagtgg tttggtccgt gtcggtgaag     2520

acgtgtacta tttcggcgag acgtacacaa ttgagacggg ctggatctat gatatggaga     2580

acgagagtga caagtactat ttcaatcctg agaccaagaa agcatgcaag gggatcaacc     2640

tgatcgatga catcaagtac tatttcgacg agaagggcat tatgcgcacg gggcttatct     2700

catttgagaa taacaattat tacttcaatg agaacgggga aatgcagttt gggtacatca     2760

atattgagga caagatgttc tattttggcg aggatggcgt catgcagatc ggggtgttca     2820

acaccccaga tggtttcaag tatttcgcgc atcagaatac gctggatgag aacttcgagg     2880

gcgaatcaat caactatacc gggtggctgg acctcgatga gaagcgctac tatttcacgg     2940

acgaatacat tgcggccacc ggctcagtca tcattgatgg cgaggaatac tatttcgacc     3000

ctgatacggc gcagctggtg atcagtgagt aatgacctag ctgataacct agcccgccta     3060

atgagcgggc ttttttttct cggcctaggt ttcacctgtt ctattaggtg ttacatgctg     3120

ttcatctgtt acattgtcga tctgttcatg gtgaacagct ttaaatgcac caaaaactcg     3180

taaaagctct gatgtatcta tcttttttac accgttttca tctgtgcata tggacagttt     3240

tccctttgat atctaacggt gaacagttgt tctacttttg tttgttagtc ttgatgcttc     3300

actgatagat acaagagcca taagaacctc agatccttcc gtatttagcc agtatgttct     3360

ctagtgtggt tcgttgtttt tgcgtgagcc atgagaacga accattgaga tcatgcttac     3420

tttgcatgtc actcaaaaat tttgcctcaa aactggtgag ctgaattttt gcagttaaag     3480

catcgtgtag tgtttttctt agtccgttac gtaggtagga atctgatgta atggttgttg     3540

gtattttgtc accattcatt tttatctggt tgttctcaag ttcggttacg agatccattt     3600

gtctatctag ttcaacttgg aaaatcaacg tatcagtcgg gcggcctcgc ttatcaacca     3660

ccaatttcat attgctgtaa gtgtttaaat ctttacttat tggtttcaaa acccattggt     3720

taagcctttt aaactcatgg tagttatttt caagcattaa catgaactta aattcatcaa     3780

ggctaatctc tatatttgcc ttgtgagttt tcttttgtgt tagttctttt aataaccact     3840

cataaatcct catagagtat ttgttttcaa aagacttaac atgttccaga ttatatttta     3900

tgaatttttt taactggaaa agataaggca atatctcttc actaaaaact aattctaatt     3960

tttcgcttga gaacttggca tagtttgtcc actggaaaat ctcaaagcct ttaaccaaag     4020

gattcctgat ttccacagtt ctcgtcatca gctctctggt tgctttagct aatacaccat     4080

aagcattttc cctactgatg ttcatcatct gagcgtattg gttataagtg aacgataccg     4140

tccgttcttt ccttgtaggg ttttcaatcg tggggttgag tagtgccaca cagcataaaa     4200

ttagcttggt ttcatgctcc gttaagtcat agcgactaat cgctagttca tttgctttga     4260

aaacaactaa ttcagacata catctcaatt ggtctaggtg attttaatca ctataccaat     4320

tgagatgggc tagtcaatga taattactag ctagtccttt tcctttgagt tgtgggtatc     4380

tgtaaattct gctagacctt tgctggaaaa cttgtaaatt ctgctagacc ctctgtaaat     4440

tccgctagac ctttgtgtgt tttttttgtt tatattcaag tggttataat ttatagaata     4500

aagaaagaat aaaaaaagat aaaaagaata gatcccagcc ctgtgtataa ctcactactt     4560

tagtcagttc cgcagtatta caaaaggatg tcgcaaacgc tgtttgctcc tctacaaaac     4620

agaccttaaa accctaaagg cttaagtagc accctcgcaa gctcgggcaa atcgctgaat     4680

attccttttg tctccgacca tcaggcacct gagtcgctgt ctttttcgtg acattcagtt     4740

cgctgcgctc acggctctgg cagtgaatgg gggtaaatgg cactacaggc gccttttatg     4800

gattcatgca aggaaactac ccataataca agaaaagccc gtcacgggct tctcagggcg     4860

ttttatggcg ggtctgctat gtggtgctat ctgacttttt gctgttcagc agttcctgcc     4920

ctctgatttt ccagtctgac cacttcggat tatcccgtga caggtcattc agactggcta     4980

atgcacccag taaggcagcg gtatcatcaa caggcttacc cgtcttactg tcaaccggat     5040

ctaaaacact aggcccaaga gtttgtagaa acgcaaaaag gccatccgtc aggatggcct     5100

tctgcttaat ttgatgcctg gcagtttatg gcgggcgtcc tgcccgccac cctccgggcc     5160

gttgcttcgc aacgttcaaa tccgctcccg gcggatttgt cctactcagg agagcgttca     5220

ccgacaaaca acagataaaa cgaaaggccc agtctttcga ctgagccttt cgttttattt     5280

gatgcctggc agttccctac tctcgcatgg ggagacccca cactaccatc ggcgctacgg     5340

cgtttcactt ctgagttcgg catggggtca ggtgggacca ccgcgctact gccgccaggc     5400

aaattctgtt ttatcagacc gcttctgcgt tctgatttaa tctgtatcag gctgaaaatc     5460

ttctctcatc cgccaaaaca gccaagctgg atctaaaaca ctagctctag ctattgtttt     5520

aatgacaaat cagaacggaa tgtcatcatc aaagtccatc ggcggctcgt tagacggcgc     5580

tgccggagcg gactgctgcg ggcgagactg cgcgccgccg ctgaactgat tgccaccctg     5640

cggctgctga ggctgacccc aaccgccctg cggctgacca ccaccgatat tgccacctgc     5700

cggagcgcca ccaccctgac gaccacccag catctgcatg gtgccgccaa cgttcaccac     5760

gacttctgtg gtgtagcgat cctgaccgga ttgatcggtc catttacggg tacgcagctg     5820

accttcgata taaacctgag aacctttacg cagatattcg ctcgccactt ctgccagttt     5880

gccgaacagc acaacgcggt gccattcagt ctgttctttc atctcgccgg tcgctttatc     5940

acgccaggat tcggaagtag ccagcgtaat gttggcaact gcgccaccat ttggcatgta     6000

gcgtacttcc gggtcctgac ccagattacc aacgagaata accttgttta cgcctctgct     6060

ggccatgttc gtgtctcctg aaaaaaatcg ttctgaataa gtgtaaacgc gcgattgtac     6120

cattaccaat agcgctttta ctatgttgtg acctcggttc cgggaaacaa acctggccag     6180

acattgttac acaacactcc ggataatgca ttccaatact gtatattcat tcaggtcaat     6240

catatgaagg gcgaattctg cagatatcca tcacactggc ggccgccagt gtgatggata     6300

tctgcagaat tcgcccttga gaagttccta ttctatatat agtataggaa cttctctaga     6360

acttttgtta cccgccaaac aaaacccaaa aacaacccat acccaaccca ataaaacacc     6420

aaaacaagac aaataatcat tgattgatgg ttgaaatggg gtaaacttga caaacaaacc     6480

cacttaaaac ccaaaacata cccaaacaca caccaaaaaa acaccataag gagttttata     6540

aatgttggta ttcattgatg acggttcaac aaacatcaaa ctacagtggc aggaaagcga     6600

cggaacaatt aaacagcaca ttagcccgaa cagcttcaaa cgcgagtggg cagtctcttt     6660

tggtgataaa aaggtcttta actacacact gaacggcgaa cagtattcat ttgatccaat     6720

cagcccggat gctgtagtca caaccaatat cgcatggcaa tacagcgacg ttaatgtcgt     6780

tgcagtgcat cacgccttac tgaccagtgg tctgccggta agcgaagtgg atattgtttg     6840

cacacttcct ctgacagagt attacgacag aaataaccaa cccaatacgg aaaatattga     6900

gcgtaagaaa gcaaacttcc ggaaaaaaat tacattaaat ggcggggata cattcacaat     6960

aaaagatgta aaagtcatgc ctgaatctat accggcaggt tatgaagttc tacaagaact     7020

ggatgagtta gattctttat taattataga tctcgggggc accacattag atatttctca     7080

ggtaatgggg aaattatcgg ggatcagtaa aatatacgga gactcatctc ttggtgtctc     7140

tctggttaca tctgcagtaa aagatgccct ttctcttgcg agaacaaaag gaagtagcta     7200

tcttgctgac gatataatca ttcacagaaa agataataac tatctgaagc aacgaattaa     7260

tgatgagaac aaaatatcaa tagtcaccga agcaatgaat gaagcacttc gtaaacttga     7320

gcaacgtgta ttaaatacgc tcaatgaatt ttctggttat actcatgtta tggttatagg     7380

cggtggcgca gaattaatat gcgatgcagt aaaaaaacac acacagattc gtgatgaacg     7440

ttttttcaaa accaataact ctcaatatga tttagttaac ggtatgtatc tcataggtaa     7500

ttaatgatgg acaagcgcag aaccattgcc ttcaaactaa atccagatgt aaatcaaaca     7560

gataaaattg tttgtgatac actggacagt atcccgcaag gggaacgaag ccgccttaac     7620

cgggccgcac tgacggcagg tctggcctta tacagacaag atccccggac ccctttcctt     7680

ttatgtgagc tgctgacgaa agaaaccaca ttttcagata tcgtgaatat attgagatcg     7740

ctatttccaa aagagatggc cgattttaat tcttcaatag tcactcaatc ctcttcacaa     7800

caagagcaaa aaagtgatga agagaccaaa aaaaatgcga tgaagctaat aaattaattc     7860

aattattatt gagttccctt tatccactat caggctggat aaagggaact caatcaagtt     7920

attttcttac cagtcattac ataatcgtta ttatgaaata atcgtttgca ctgtctctgt     7980

tattcaggca atttcaataa aggcacttgc tcacgctctg tcattttctg aaactcttca     8040

tgctg                                                                 8045


<210>  8
<211>  838
<212>  PRT
<213>  artificial

<220>
<223>  synthetic

<400>  8

Met Thr Ser Ile Phe Ala Glu Gln Thr Val Glu Val Val Lys Ser Ala 
1               5                   10                  15      


Ile Glu Thr Ala Asp Gly Ala Leu Asp Leu Tyr Asn Lys Tyr Leu Asp 
            20                  25                  30          


Gln Val Ile Pro Trp Lys Thr Phe Asp Glu Thr Ile Lys Glu Leu Ser 
        35                  40                  45              


Arg Phe Lys Gln Glu Tyr Ser Gln Glu Ala Ser Val Leu Val Gly Asp 
    50                  55                  60                  


Ile Lys Val Leu Leu Met Asp Ser Gln Asp Lys Tyr Phe Glu Ala Thr 
65                  70                  75                  80  


Gln Thr Val Tyr Glu Trp Cys Gly Val Val Thr Gln Leu Leu Ser Ala 
                85                  90                  95      


Tyr Ile Leu Leu Phe Asp Glu Tyr Asn Glu Lys Lys Ala Ser Ala Gln 
            100                 105                 110         


Lys Asp Ile Leu Ile Arg Ile Leu Asp Asp Gly Val Lys Lys Leu Asn 
        115                 120                 125             


Glu Ala Gln Lys Ser Leu Leu Thr Ser Ser Gln Ser Phe Asn Asn Ala 
    130                 135                 140                 


Ser Gly Lys Leu Leu Ala Leu Asp Ser Gln Leu Thr Asn Asp Phe Ser 
145                 150                 155                 160 


Glu Lys Ser Ser Tyr Phe Gln Ser Gln Val Asp Arg Ile Arg Lys Glu 
                165                 170                 175     


Ala Tyr Ala Gly Ala Ala Ala Gly Ile Val Ala Gly Pro Phe Gly Leu 
            180                 185                 190         


Ile Ile Ser Tyr Ser Ile Ala Ala Gly Val Ile Glu Gly Lys Leu Ile 
        195                 200                 205             


Pro Glu Leu Asn Asn Arg Leu Lys Thr Val Gln Asn Phe Phe Thr Ser 
    210                 215                 220                 


Leu Ser Ala Thr Val Lys Gln Ala Asn Lys Asp Ile Asp Ala Ala Lys 
225                 230                 235                 240 


Leu Lys Leu Ala Thr Glu Ile Ala Ala Ile Gly Glu Ile Lys Thr Glu 
                245                 250                 255     


Thr Glu Thr Thr Arg Phe Tyr Val Asp Tyr Asp Asp Leu Met Leu Ser 
            260                 265                 270         


Leu Leu Lys Gly Ala Ala Lys Lys Met Ile Asn Thr Cys Asn Glu Tyr 
        275                 280                 285             


Gln Gln Arg His Gly Lys Lys Thr Leu Phe Glu Val Pro Asp Val Ala 
    290                 295                 300                 


Ser Gly Leu Ile Tyr Ile Asn Asp Ser Leu Tyr Tyr Phe Lys Pro Pro 
305                 310                 315                 320 


Val Asn Asn Leu Ile Thr Gly Phe Val Thr Val Gly Asp Asp Lys Tyr 
                325                 330                 335     


Tyr Phe Asn Pro Ile Asn Gly Gly Ala Ala Ser Ile Gly Glu Thr Ile 
            340                 345                 350         


Ile Asp Asp Lys Asn Tyr Tyr Phe Asn Gln Ser Gly Val Leu Gln Thr 
        355                 360                 365             


Gly Val Phe Ser Thr Glu Asp Gly Phe Lys Tyr Phe Ala Pro Ala Asn 
    370                 375                 380                 


Thr Leu Asp Glu Asn Leu Glu Gly Glu Ala Ile Asp Phe Thr Gly Lys 
385                 390                 395                 400 


Leu Ile Ile Asp Glu Asn Ile Tyr Tyr Phe Asp Asp Asn Tyr Arg Gly 
                405                 410                 415     


Ala Val Glu Trp Lys Glu Leu Asp Gly Glu Met His Tyr Phe Ser Pro 
            420                 425                 430         


Glu Thr Gly Lys Ala Phe Lys Gly Leu Asn Gln Ile Gly Asp Tyr Lys 
        435                 440                 445             


Tyr Tyr Phe Asn Ser Asp Gly Val Met Gln Lys Gly Phe Val Ser Ile 
    450                 455                 460                 


Asn Asp Asn Lys His Tyr Phe Asp Asp Ser Gly Val Met Lys Val Gly 
465                 470                 475                 480 


Tyr Thr Glu Ile Asp Gly Lys His Phe Tyr Phe Ala Glu Asn Gly Glu 
                485                 490                 495     


Met Gln Ile Gly Val Phe Asn Thr Glu Asp Gly Phe Lys Tyr Phe Ala 
            500                 505                 510         


His His Asn Glu Asp Leu Gly Asn Glu Glu Gly Glu Glu Ile Ser Tyr 
        515                 520                 525             


Ser Gly Ile Leu Asn Phe Asn Asn Lys Ile Tyr Tyr Phe Asp Asp Ser 
    530                 535                 540                 


Phe Thr Ala Val Val Gly Trp Lys Asp Leu Glu Asp Gly Ser Lys Tyr 
545                 550                 555                 560 


Tyr Phe Asp Glu Asp Thr Ala Glu Ala Tyr Ile Gly Leu Ser Leu Ile 
                565                 570                 575     


Asn Asp Gly Gln Tyr Tyr Phe Asn Asp Asp Gly Ile Met Gln Val Gly 
            580                 585                 590         


Phe Val Thr Ile Asn Asp Lys Val Phe Tyr Phe Ser Asp Ser Gly Ile 
        595                 600                 605             


Ile Glu Ser Gly Val Gln Asn Ile Asp Asp Asn Tyr Phe Tyr Ile Asp 
    610                 615                 620                 


Asp Asn Gly Ile Val Gln Ile Gly Val Phe Asp Thr Ser Asp Gly Tyr 
625                 630                 635                 640 


Lys Tyr Phe Ala Pro Ala Asn Thr Val Asn Asp Asn Ile Tyr Gly Gln 
                645                 650                 655     


Ala Val Glu Tyr Ser Gly Leu Val Arg Val Gly Glu Asp Val Tyr Tyr 
            660                 665                 670         


Phe Gly Glu Thr Tyr Thr Ile Glu Thr Gly Trp Ile Tyr Asp Met Glu 
        675                 680                 685             


Asn Glu Ser Asp Lys Tyr Tyr Phe Asn Pro Glu Thr Lys Lys Ala Cys 
    690                 695                 700                 


Lys Gly Ile Asn Leu Ile Asp Asp Ile Lys Tyr Tyr Phe Asp Glu Lys 
705                 710                 715                 720 


Gly Ile Met Arg Thr Gly Leu Ile Ser Phe Glu Asn Asn Asn Tyr Tyr 
                725                 730                 735     


Phe Asn Glu Asn Gly Glu Met Gln Phe Gly Tyr Ile Asn Ile Glu Asp 
            740                 745                 750         


Lys Met Phe Tyr Phe Gly Glu Asp Gly Val Met Gln Ile Gly Val Phe 
        755                 760                 765             


Asn Thr Pro Asp Gly Phe Lys Tyr Phe Ala His Gln Asn Thr Leu Asp 
    770                 775                 780                 


Glu Asn Phe Glu Gly Glu Ser Ile Asn Tyr Thr Gly Trp Leu Asp Leu 
785                 790                 795                 800 


Asp Glu Lys Arg Tyr Tyr Phe Thr Asp Glu Tyr Ile Ala Ala Thr Gly 
                805                 810                 815     


Ser Val Ile Ile Asp Gly Glu Glu Tyr Tyr Phe Asp Pro Asp Thr Ala 
            820                 825                 830         


Gln Leu Val Ile Ser Glu 
        835             


<210>  9
<211>  8045
<212>  DNA
<213>  artificial

<220>
<223>  synthetic

<400>  9
gaattctgtg gtagcacaga ataatgaaaa gtgtgtaaag aagggtaaaa aaaaccgaat       60

gcgaggcatc cggttgaaat aggggtaaac agacattcag aaatgaatga cggtaataaa      120

taaagttaat gatgatagcg ggagttattc tagttgcgag tgaaggtttt gttttgacat      180

tcagtgctgt caaatactta agaataagtt attgatttta accttgaatt attattgctt      240

gatgttaggt gcttatttcg ccattccgca ataatcttaa aaagttccct tgcatttaca      300

ttttgaaaca tctatagcga taaatgaaac atcttaaaag ttttagtatc atattcgtgt      360

tggattattc tgcatttttg gggagaatgg acttgccgac tgattaatga gggttaatca      420

gtatgcagtg gcataaaaaa gcaaataaag gcatataaca gatcgatctt aaacatccac      480

aggaggatgg gatccaaaat aaggaggaaa aaaaaatgac tagtattttt gcagaacaaa      540

ctgtagaggt agttaaaagc gcgatcgaaa ccgcagatgg ggcattagat ctttataaca      600

aatacctcga ccaggtcatc ccctggaaga cctttgatga aaccataaaa gagttaagcc      660

gttttaaaca ggagtactcg caggaagctt ctgttttagt tggtgatatt aaagttttgc      720

ttatggacag ccaggacaag tattttgaag cgacacaaac tgtttatgaa tggtgtggtg      780

tcgtgacgca attactctca gcgtatattt tactatttga tgaatataat gagaaaaaag      840

catcagccca gaaagacatt ctcattagga tattagatga tggtgtcaag aaactgaatg      900

aagcgcaaaa atctctcctg acaagttcac aaagtttcaa caacgcttcc ggaaaactgc      960

tggcattaga tagccagtta actaatgatt tttcggaaaa aagtagttat ttccagtcac     1020

aggtggatag aattcgtaag gaagcttatg ccggtgctgc agccggcata gtcgccggtc     1080

cgtttggatt aattatttcc tattctaatg ctgcgggcgt gattgaaggg aaattgattc     1140

cagaattgaa taacaggcta aaaacagtgc aaaatttctt tactagctta tcagctacag     1200

tgaaacaagc gaataaagat atcgatgcgg caaaattgaa attagccact gaaatagcag     1260

caattgggga gataaaaacg gaaaccgaaa caaccagatt ctacgttgat tatgatgatt     1320

taatgctttc tttattaaaa ggagctgcaa agaaaatgat taacacctgg aatgaatacc     1380

aacaacgtca tggtaagaag acgcttttcg aggttcctga cgtcgctagc ggcctgatct     1440

atattaacga ttcactgtac tatttcaagc cgcccgtcaa taacctcatc accgggtttg     1500

tgacggtcgg cgacgataaa tactacttca atccgatcaa cggcggagcc gcgagcattg     1560

gggagaccat cattgatgac aagaattatt acttcaacca gagtggcgtg ctgcagacgg     1620

gggtcttcag taccgaggac ggctttaaat acttcgcccc cgcgaatacg ctcgatgaga     1680

acctggaagg ggaggcgatt gactttaccg gcaagctgat cattgacgag aacatctact     1740

atttcgatga caattaccgc ggggccgtgg aatggaagga gctcgatggc gagatgcact     1800

attttagccc ggagacgggg aaagctttca aaggcctgaa tcaaattggg gactacaagt     1860

attacttcaa ctctgacggt gtgatgcaga aggggttcgt gagtatcaat gacaacaagc     1920

attatttcga cgattctggc gtcatgaaag tggggtacac cgagatcgat ggcaagcact     1980

tctactttgc cgagaatggt gagatgcaaa tcggcgtgtt caatacggaa gacgggttta     2040

agtatttcgc gcatcataac gaggatctcg gcaatgaaga gggcgaagag atctcatatt     2100

ccggaatcct caacttcaat aacaagattt actactttga tgactcattt accgccgtgg     2160

tcggctggaa ggacctcgag gatgggtcaa agtactattt cgacgaggat acggcggagg     2220

cctacatcgg cctgtcatta atcaacgacg gccagtatta ctttaatgat gacggcatca     2280

tgcaggtcgg gtttgtcacc atcaacgata aagtcttcta cttctctgac tctggcatta     2340

tcgagagcgg ggtgcagaac atcgacgata actatttcta catcgatgac aatggcattg     2400

tccagatcgg cgtgttcgat acgtcagacg gttataagta ttttgcgccc gccaacaccg     2460

tcaacgataa tatctacggt caagctgttg aatatagtgg tttggtccgt gtcggtgaag     2520

acgtgtacta tttcggcgag acgtacacaa ttgagacggg ctggatctat gatatggaga     2580

acgagagtga caagtactat ttcaatcctg agaccaagaa agcatgcaag gggatcaacc     2640

tgatcgatga catcaagtac tatttcgacg agaagggcat tatgcgcacg gggcttatct     2700

catttgagaa taacaattat tacttcaatg agaacgggga aatgcagttt gggtacatca     2760

atattgagga caagatgttc tattttggcg aggatggcgt catgcagatc ggggtgttca     2820

acaccccaga tggtttcaag tatttcgcgc atcagaatac gctggatgag aacttcgagg     2880

gcgaatcaat caactatacc gggtggctgg acctcgatga gaagcgctac tatttcacgg     2940

acgaatacat tgcggccacc ggctcagtca tcattgatgg cgaggaatac tatttcgacc     3000

ctgatacggc gcagctggtg atcagtgagt aatgacctag ctgataacct agcccgccta     3060

atgagcgggc ttttttttct cggcctaggt ttcacctgtt ctattaggtg ttacatgctg     3120

ttcatctgtt acattgtcga tctgttcatg gtgaacagct ttaaatgcac caaaaactcg     3180

taaaagctct gatgtatcta tcttttttac accgttttca tctgtgcata tggacagttt     3240

tccctttgat atctaacggt gaacagttgt tctacttttg tttgttagtc ttgatgcttc     3300

actgatagat acaagagcca taagaacctc agatccttcc gtatttagcc agtatgttct     3360

ctagtgtggt tcgttgtttt tgcgtgagcc atgagaacga accattgaga tcatgcttac     3420

tttgcatgtc actcaaaaat tttgcctcaa aactggtgag ctgaattttt gcagttaaag     3480

catcgtgtag tgtttttctt agtccgttac gtaggtagga atctgatgta atggttgttg     3540

gtattttgtc accattcatt tttatctggt tgttctcaag ttcggttacg agatccattt     3600

gtctatctag ttcaacttgg aaaatcaacg tatcagtcgg gcggcctcgc ttatcaacca     3660

ccaatttcat attgctgtaa gtgtttaaat ctttacttat tggtttcaaa acccattggt     3720

taagcctttt aaactcatgg tagttatttt caagcattaa catgaactta aattcatcaa     3780

ggctaatctc tatatttgcc ttgtgagttt tcttttgtgt tagttctttt aataaccact     3840

cataaatcct catagagtat ttgttttcaa aagacttaac atgttccaga ttatatttta     3900

tgaatttttt taactggaaa agataaggca atatctcttc actaaaaact aattctaatt     3960

tttcgcttga gaacttggca tagtttgtcc actggaaaat ctcaaagcct ttaaccaaag     4020

gattcctgat ttccacagtt ctcgtcatca gctctctggt tgctttagct aatacaccat     4080

aagcattttc cctactgatg ttcatcatct gagcgtattg gttataagtg aacgataccg     4140

tccgttcttt ccttgtaggg ttttcaatcg tggggttgag tagtgccaca cagcataaaa     4200

ttagcttggt ttcatgctcc gttaagtcat agcgactaat cgctagttca tttgctttga     4260

aaacaactaa ttcagacata catctcaatt ggtctaggtg attttaatca ctataccaat     4320

tgagatgggc tagtcaatga taattactag ctagtccttt tcctttgagt tgtgggtatc     4380

tgtaaattct gctagacctt tgctggaaaa cttgtaaatt ctgctagacc ctctgtaaat     4440

tccgctagac ctttgtgtgt tttttttgtt tatattcaag tggttataat ttatagaata     4500

aagaaagaat aaaaaaagat aaaaagaata gatcccagcc ctgtgtataa ctcactactt     4560

tagtcagttc cgcagtatta caaaaggatg tcgcaaacgc tgtttgctcc tctacaaaac     4620

agaccttaaa accctaaagg cttaagtagc accctcgcaa gctcgggcaa atcgctgaat     4680

attccttttg tctccgacca tcaggcacct gagtcgctgt ctttttcgtg acattcagtt     4740

cgctgcgctc acggctctgg cagtgaatgg gggtaaatgg cactacaggc gccttttatg     4800

gattcatgca aggaaactac ccataataca agaaaagccc gtcacgggct tctcagggcg     4860

ttttatggcg ggtctgctat gtggtgctat ctgacttttt gctgttcagc agttcctgcc     4920

ctctgatttt ccagtctgac cacttcggat tatcccgtga caggtcattc agactggcta     4980

atgcacccag taaggcagcg gtatcatcaa caggcttacc cgtcttactg tcaaccggat     5040

ctaaaacact aggcccaaga gtttgtagaa acgcaaaaag gccatccgtc aggatggcct     5100

tctgcttaat ttgatgcctg gcagtttatg gcgggcgtcc tgcccgccac cctccgggcc     5160

gttgcttcgc aacgttcaaa tccgctcccg gcggatttgt cctactcagg agagcgttca     5220

ccgacaaaca acagataaaa cgaaaggccc agtctttcga ctgagccttt cgttttattt     5280

gatgcctggc agttccctac tctcgcatgg ggagacccca cactaccatc ggcgctacgg     5340

cgtttcactt ctgagttcgg catggggtca ggtgggacca ccgcgctact gccgccaggc     5400

aaattctgtt ttatcagacc gcttctgcgt tctgatttaa tctgtatcag gctgaaaatc     5460

ttctctcatc cgccaaaaca gccaagctgg atctaaaaca ctagctctag ctattgtttt     5520

aatgacaaat cagaacggaa tgtcatcatc aaagtccatc ggcggctcgt tagacggcgc     5580

tgccggagcg gactgctgcg ggcgagactg cgcgccgccg ctgaactgat tgccaccctg     5640

cggctgctga ggctgacccc aaccgccctg cggctgacca ccaccgatat tgccacctgc     5700

cggagcgcca ccaccctgac gaccacccag catctgcatg gtgccgccaa cgttcaccac     5760

gacttctgtg gtgtagcgat cctgaccgga ttgatcggtc catttacggg tacgcagctg     5820

accttcgata taaacctgag aacctttacg cagatattcg ctcgccactt ctgccagttt     5880

gccgaacagc acaacgcggt gccattcagt ctgttctttc atctcgccgg tcgctttatc     5940

acgccaggat tcggaagtag ccagcgtaat gttggcaact gcgccaccat ttggcatgta     6000

gcgtacttcc gggtcctgac ccagattacc aacgagaata accttgttta cgcctctgct     6060

ggccatgttc gtgtctcctg aaaaaaatcg ttctgaataa gtgtaaacgc gcgattgtac     6120

cattaccaat agcgctttta ctatgttgtg acctcggttc cgggaaacaa acctggccag     6180

acattgttac acaacactcc ggataatgca ttccaatact gtatattcat tcaggtcaat     6240

catatgaagg gcgaattctg cagatatcca tcacactggc ggccgccagt gtgatggata     6300

tctgcagaat tcgcccttga gaagttccta ttctatatat agtataggaa cttctctaga     6360

acttttgtta cccgccaaac aaaacccaaa aacaacccat acccaaccca ataaaacacc     6420

aaaacaagac aaataatcat tgattgatgg ttgaaatggg gtaaacttga caaacaaacc     6480

cacttaaaac ccaaaacata cccaaacaca caccaaaaaa acaccataag gagttttata     6540

aatgttggta ttcattgatg acggttcaac aaacatcaaa ctacagtggc aggaaagcga     6600

cggaacaatt aaacagcaca ttagcccgaa cagcttcaaa cgcgagtggg cagtctcttt     6660

tggtgataaa aaggtcttta actacacact gaacggcgaa cagtattcat ttgatccaat     6720

cagcccggat gctgtagtca caaccaatat cgcatggcaa tacagcgacg ttaatgtcgt     6780

tgcagtgcat cacgccttac tgaccagtgg tctgccggta agcgaagtgg atattgtttg     6840

cacacttcct ctgacagagt attacgacag aaataaccaa cccaatacgg aaaatattga     6900

gcgtaagaaa gcaaacttcc ggaaaaaaat tacattaaat ggcggggata cattcacaat     6960

aaaagatgta aaagtcatgc ctgaatctat accggcaggt tatgaagttc tacaagaact     7020

ggatgagtta gattctttat taattataga tctcgggggc accacattag atatttctca     7080

ggtaatgggg aaattatcgg ggatcagtaa aatatacgga gactcatctc ttggtgtctc     7140

tctggttaca tctgcagtaa aagatgccct ttctcttgcg agaacaaaag gaagtagcta     7200

tcttgctgac gatataatca ttcacagaaa agataataac tatctgaagc aacgaattaa     7260

tgatgagaac aaaatatcaa tagtcaccga agcaatgaat gaagcacttc gtaaacttga     7320

gcaacgtgta ttaaatacgc tcaatgaatt ttctggttat actcatgtta tggttatagg     7380

cggtggcgca gaattaatat gcgatgcagt aaaaaaacac acacagattc gtgatgaacg     7440

ttttttcaaa accaataact ctcaatatga tttagttaac ggtatgtatc tcataggtaa     7500

ttaatgatgg acaagcgcag aaccattgcc ttcaaactaa atccagatgt aaatcaaaca     7560

gataaaattg tttgtgatac actggacagt atcccgcaag gggaacgaag ccgccttaac     7620

cgggccgcac tgacggcagg tctggcctta tacagacaag atccccggac ccctttcctt     7680

ttatgtgagc tgctgacgaa agaaaccaca ttttcagata tcgtgaatat attgagatcg     7740

ctatttccaa aagagatggc cgattttaat tcttcaatag tcactcaatc ctcttcacaa     7800

caagagcaaa aaagtgatga agagaccaaa aaaaatgcga tgaagctaat aaattaattc     7860

aattattatt gagttccctt tatccactat caggctggat aaagggaact caatcaagtt     7920

attttcttac cagtcattac ataatcgtta ttatgaaata atcgtttgca ctgtctctgt     7980

tattcaggca atttcaataa aggcacttgc tcacgctctg tcattttctg aaactcttca     8040

tgctg                                                                 8045


<210>  10
<211>  838
<212>  PRT
<213>  artificial

<220>
<223>  synthetic

<400>  10

Met Thr Ser Ile Phe Ala Glu Gln Thr Val Glu Val Val Lys Ser Ala 
1               5                   10                  15      


Ile Glu Thr Ala Asp Gly Ala Leu Asp Leu Tyr Asn Lys Tyr Leu Asp 
            20                  25                  30          


Gln Val Ile Pro Trp Lys Thr Phe Asp Glu Thr Ile Lys Glu Leu Ser 
        35                  40                  45              


Arg Phe Lys Gln Glu Tyr Ser Gln Glu Ala Ser Val Leu Val Gly Asp 
    50                  55                  60                  


Ile Lys Val Leu Leu Met Asp Ser Gln Asp Lys Tyr Phe Glu Ala Thr 
65                  70                  75                  80  


Gln Thr Val Tyr Glu Trp Cys Gly Val Val Thr Gln Leu Leu Ser Ala 
                85                  90                  95      


Tyr Ile Leu Leu Phe Asp Glu Tyr Asn Glu Lys Lys Ala Ser Ala Gln 
            100                 105                 110         


Lys Asp Ile Leu Ile Arg Ile Leu Asp Asp Gly Val Lys Lys Leu Asn 
        115                 120                 125             


Glu Ala Gln Lys Ser Leu Leu Thr Ser Ser Gln Ser Phe Asn Asn Ala 
    130                 135                 140                 


Ser Gly Lys Leu Leu Ala Leu Asp Ser Gln Leu Thr Asn Asp Phe Ser 
145                 150                 155                 160 


Glu Lys Ser Ser Tyr Phe Gln Ser Gln Val Asp Arg Ile Arg Lys Glu 
                165                 170                 175     


Ala Tyr Ala Gly Ala Ala Ala Gly Ile Val Ala Gly Pro Phe Gly Leu 
            180                 185                 190         


Ile Ile Ser Tyr Ser Asn Ala Ala Gly Val Ile Glu Gly Lys Leu Ile 
        195                 200                 205             


Pro Glu Leu Asn Asn Arg Leu Lys Thr Val Gln Asn Phe Phe Thr Ser 
    210                 215                 220                 


Leu Ser Ala Thr Val Lys Gln Ala Asn Lys Asp Ile Asp Ala Ala Lys 
225                 230                 235                 240 


Leu Lys Leu Ala Thr Glu Ile Ala Ala Ile Gly Glu Ile Lys Thr Glu 
                245                 250                 255     


Thr Glu Thr Thr Arg Phe Tyr Val Asp Tyr Asp Asp Leu Met Leu Ser 
            260                 265                 270         


Leu Leu Lys Gly Ala Ala Lys Lys Met Ile Asn Thr Trp Asn Glu Tyr 
        275                 280                 285             


Gln Gln Arg His Gly Lys Lys Thr Leu Phe Glu Val Pro Asp Val Ala 
    290                 295                 300                 


Ser Gly Leu Ile Tyr Ile Asn Asp Ser Leu Tyr Tyr Phe Lys Pro Pro 
305                 310                 315                 320 


Val Asn Asn Leu Ile Thr Gly Phe Val Thr Val Gly Asp Asp Lys Tyr 
                325                 330                 335     


Tyr Phe Asn Pro Ile Asn Gly Gly Ala Ala Ser Ile Gly Glu Thr Ile 
            340                 345                 350         


Ile Asp Asp Lys Asn Tyr Tyr Phe Asn Gln Ser Gly Val Leu Gln Thr 
        355                 360                 365             


Gly Val Phe Ser Thr Glu Asp Gly Phe Lys Tyr Phe Ala Pro Ala Asn 
    370                 375                 380                 


Thr Leu Asp Glu Asn Leu Glu Gly Glu Ala Ile Asp Phe Thr Gly Lys 
385                 390                 395                 400 


Leu Ile Ile Asp Glu Asn Ile Tyr Tyr Phe Asp Asp Asn Tyr Arg Gly 
                405                 410                 415     


Ala Val Glu Trp Lys Glu Leu Asp Gly Glu Met His Tyr Phe Ser Pro 
            420                 425                 430         


Glu Thr Gly Lys Ala Phe Lys Gly Leu Asn Gln Ile Gly Asp Tyr Lys 
        435                 440                 445             


Tyr Tyr Phe Asn Ser Asp Gly Val Met Gln Lys Gly Phe Val Ser Ile 
    450                 455                 460                 


Asn Asp Asn Lys His Tyr Phe Asp Asp Ser Gly Val Met Lys Val Gly 
465                 470                 475                 480 


Tyr Thr Glu Ile Asp Gly Lys His Phe Tyr Phe Ala Glu Asn Gly Glu 
                485                 490                 495     


Met Gln Ile Gly Val Phe Asn Thr Glu Asp Gly Phe Lys Tyr Phe Ala 
            500                 505                 510         


His His Asn Glu Asp Leu Gly Asn Glu Glu Gly Glu Glu Ile Ser Tyr 
        515                 520                 525             


Ser Gly Ile Leu Asn Phe Asn Asn Lys Ile Tyr Tyr Phe Asp Asp Ser 
    530                 535                 540                 


Phe Thr Ala Val Val Gly Trp Lys Asp Leu Glu Asp Gly Ser Lys Tyr 
545                 550                 555                 560 


Tyr Phe Asp Glu Asp Thr Ala Glu Ala Tyr Ile Gly Leu Ser Leu Ile 
                565                 570                 575     


Asn Asp Gly Gln Tyr Tyr Phe Asn Asp Asp Gly Ile Met Gln Val Gly 
            580                 585                 590         


Phe Val Thr Ile Asn Asp Lys Val Phe Tyr Phe Ser Asp Ser Gly Ile 
        595                 600                 605             


Ile Glu Ser Gly Val Gln Asn Ile Asp Asp Asn Tyr Phe Tyr Ile Asp 
    610                 615                 620                 


Asp Asn Gly Ile Val Gln Ile Gly Val Phe Asp Thr Ser Asp Gly Tyr 
625                 630                 635                 640 


Lys Tyr Phe Ala Pro Ala Asn Thr Val Asn Asp Asn Ile Tyr Gly Gln 
                645                 650                 655     


Ala Val Glu Tyr Ser Gly Leu Val Arg Val Gly Glu Asp Val Tyr Tyr 
            660                 665                 670         


Phe Gly Glu Thr Tyr Thr Ile Glu Thr Gly Trp Ile Tyr Asp Met Glu 
        675                 680                 685             


Asn Glu Ser Asp Lys Tyr Tyr Phe Asn Pro Glu Thr Lys Lys Ala Cys 
    690                 695                 700                 


Lys Gly Ile Asn Leu Ile Asp Asp Ile Lys Tyr Tyr Phe Asp Glu Lys 
705                 710                 715                 720 


Gly Ile Met Arg Thr Gly Leu Ile Ser Phe Glu Asn Asn Asn Tyr Tyr 
                725                 730                 735     


Phe Asn Glu Asn Gly Glu Met Gln Phe Gly Tyr Ile Asn Ile Glu Asp 
            740                 745                 750         


Lys Met Phe Tyr Phe Gly Glu Asp Gly Val Met Gln Ile Gly Val Phe 
        755                 760                 765             


Asn Thr Pro Asp Gly Phe Lys Tyr Phe Ala His Gln Asn Thr Leu Asp 
    770                 775                 780                 


Glu Asn Phe Glu Gly Glu Ser Ile Asn Tyr Thr Gly Trp Leu Asp Leu 
785                 790                 795                 800 


Asp Glu Lys Arg Tyr Tyr Phe Thr Asp Glu Tyr Ile Ala Ala Thr Gly 
                805                 810                 815     


Ser Val Ile Ile Asp Gly Glu Glu Tyr Tyr Phe Asp Pro Asp Thr Ala 
            820                 825                 830         


Gln Leu Val Ile Ser Glu 
        835             


<210>  11
<211>  7139
<212>  DNA
<213>  artificial

<220>
<223>  synthetic

<400>  11
gaattctgtg gtagcacaga ataatgaaaa gtgtgtaaag aagggtaaaa aaaaccgaat       60

gcgaggcatc cggttgaaat aggggtaaac agacattcag aaatgaatga cggtaataaa      120

taaagttaat gatgatagcg ggagttattc tagttgcgag tgaaggtttt gttttgacat      180

tcagtgctgt caaatactta agaataagtt attgatttta accttgaatt attattgctt      240

gatgttaggt gcttatttcg ccattccgca ataatcttaa aaagttccct tgcatttaca      300

ttttgaaaca tctatagcga taaatgaaac atcttaaaag ttttagtatc atattcgtgt      360

tggattattc tgcatttttg gggagaatgg acttgccgac tgattaatga gggttaatca      420

gtatgcagtg gcataaaaaa gcaaataaag gcatataaca gatcgatctt aaacatccac      480

aggaggatgg gatccaaaat aaggaggaaa aaaaaatgac tagcggcctg atctatatta      540

acgattcact gtactatttc aagccgcccg tcaataacct catcaccggg tttgtgacgg      600

tcggcgacga taaatactac ttcaatccga tcaacggcgg agccgcgagc attggggaga      660

ccatcattga tgacaagaat tattacttca accagagtgg cgtgctgcag acgggggtct      720

tcagtaccga ggacggcttt aaatacttcg cccccgcgaa tacgctcgat gagaacctgg      780

aaggggaggc gattgacttt accggcaagc tgatcattga cgagaacatc tactatttcg      840

atgacaatta ccgcggggcc gtggaatgga aggagctcga tggcgagatg cactatttta      900

gcccggagac ggggaaagct ttcaaaggcc tgaatcaaat tggggactac aagtattact      960

tcaactctga cggtgtgatg cagaaggggt tcgtgagtat caatgacaac aagcattatt     1020

tcgacgattc tggcgtcatg aaagtggggt acaccgagat cgatggcaag cacttctact     1080

ttgccgagaa tggtgagatg caaatcggcg tgttcaatac ggaagacggg tttaagtatt     1140

tcgcgcatca taacgaggat ctcggcaatg aagagggcga agagatctca tattccggaa     1200

tcctcaactt caataacaag atttactact ttgatgactc atttaccgcc gtggtcggct     1260

ggaaggacct cgaggatggg tcaaagtact atttcgacga ggatacggcg gaggcctaca     1320

tcggcctgtc attaatcaac gacggccagt attactttaa tgatgacggc atcatgcagg     1380

tcgggtttgt caccatcaac gataaagtct tctacttctc tgactctggc attatcgaga     1440

gcggggtgca gaacatcgac gataactatt tctacatcga tgacaatggc attgtccaga     1500

tcggcgtgtt cgatacgtca gacggttata agtattttgc gcccgccaac accgtcaacg     1560

ataatatcta cggtcaagct gttgaatata gtggtttggt ccgtgtcggt gaagacgtgt     1620

actatttcgg cgagacgtac acaattgaga cgggctggat ctatgatatg gagaacgaga     1680

gtgacaagta ctatttcaat cctgagacca agaaagcatg caaggggatc aacctgatcg     1740

atgacatcaa gtactatttc gacgagaagg gcattatgcg cacggggctt atctcatttg     1800

agaataacaa ttattacttc aatgagaacg gggaaatgca gtttgggtac atcaatattg     1860

aggacaagat gttctatttt ggcgaggatg gcgtcatgca gatcggggtg ttcaacaccc     1920

cagatggttt caagtatttc gcgcatcaga atacgctgga tgagaacttc gagggcgaat     1980

caatcaacta taccgggtgg ctggacctcg atgagaagcg ctactatttc acggacgaat     2040

acattgcggc caccggctca gtcatcattg atggcgagga atactatttc gaccctgata     2100

cggcgcagct ggtgatcagt gagtaatgac ctagctgata acctagcccg cctaatgagc     2160

gggctttttt ttctcggcct aggtttcacc tgttctatta ggtgttacat gctgttcatc     2220

tgttacattg tcgatctgtt catggtgaac agctttaaat gcaccaaaaa ctcgtaaaag     2280

ctctgatgta tctatctttt ttacaccgtt ttcatctgtg catatggaca gttttccctt     2340

tgatatctaa cggtgaacag ttgttctact tttgtttgtt agtcttgatg cttcactgat     2400

agatacaaga gccataagaa cctcagatcc ttccgtattt agccagtatg ttctctagtg     2460

tggttcgttg tttttgcgtg agccatgaga acgaaccatt gagatcatgc ttactttgca     2520

tgtcactcaa aaattttgcc tcaaaactgg tgagctgaat ttttgcagtt aaagcatcgt     2580

gtagtgtttt tcttagtccg ttacgtaggt aggaatctga tgtaatggtt gttggtattt     2640

tgtcaccatt catttttatc tggttgttct caagttcggt tacgagatcc atttgtctat     2700

ctagttcaac ttggaaaatc aacgtatcag tcgggcggcc tcgcttatca accaccaatt     2760

tcatattgct gtaagtgttt aaatctttac ttattggttt caaaacccat tggttaagcc     2820

ttttaaactc atggtagtta ttttcaagca ttaacatgaa cttaaattca tcaaggctaa     2880

tctctatatt tgccttgtga gttttctttt gtgttagttc ttttaataac cactcataaa     2940

tcctcataga gtatttgttt tcaaaagact taacatgttc cagattatat tttatgaatt     3000

tttttaactg gaaaagataa ggcaatatct cttcactaaa aactaattct aatttttcgc     3060

ttgagaactt ggcatagttt gtccactgga aaatctcaaa gcctttaacc aaaggattcc     3120

tgatttccac agttctcgtc atcagctctc tggttgcttt agctaataca ccataagcat     3180

tttccctact gatgttcatc atctgagcgt attggttata agtgaacgat accgtccgtt     3240

ctttccttgt agggttttca atcgtggggt tgagtagtgc cacacagcat aaaattagct     3300

tggtttcatg ctccgttaag tcatagcgac taatcgctag ttcatttgct ttgaaaacaa     3360

ctaattcaga catacatctc aattggtcta ggtgatttta atcactatac caattgagat     3420

gggctagtca atgataatta ctagctagtc cttttccttt gagttgtggg tatctgtaaa     3480

ttctgctaga cctttgctgg aaaacttgta aattctgcta gaccctctgt aaattccgct     3540

agacctttgt gtgttttttt tgtttatatt caagtggtta taatttatag aataaagaaa     3600

gaataaaaaa agataaaaag aatagatccc agccctgtgt ataactcact actttagtca     3660

gttccgcagt attacaaaag gatgtcgcaa acgctgtttg ctcctctaca aaacagacct     3720

taaaacccta aaggcttaag tagcaccctc gcaagctcgg gcaaatcgct gaatattcct     3780

tttgtctccg accatcaggc acctgagtcg ctgtcttttt cgtgacattc agttcgctgc     3840

gctcacggct ctggcagtga atgggggtaa atggcactac aggcgccttt tatggattca     3900

tgcaaggaaa ctacccataa tacaagaaaa gcccgtcacg ggcttctcag ggcgttttat     3960

ggcgggtctg ctatgtggtg ctatctgact ttttgctgtt cagcagttcc tgccctctga     4020

ttttccagtc tgaccacttc ggattatccc gtgacaggtc attcagactg gctaatgcac     4080

ccagtaaggc agcggtatca tcaacaggct tacccgtctt actgtcaacc ggatctaaaa     4140

cactaggccc aagagtttgt agaaacgcaa aaaggccatc cgtcaggatg gccttctgct     4200

taatttgatg cctggcagtt tatggcgggc gtcctgcccg ccaccctccg ggccgttgct     4260

tcgcaacgtt caaatccgct cccggcggat ttgtcctact caggagagcg ttcaccgaca     4320

aacaacagat aaaacgaaag gcccagtctt tcgactgagc ctttcgtttt atttgatgcc     4380

tggcagttcc ctactctcgc atggggagac cccacactac catcggcgct acggcgtttc     4440

acttctgagt tcggcatggg gtcaggtggg accaccgcgc tactgccgcc aggcaaattc     4500

tgttttatca gaccgcttct gcgttctgat ttaatctgta tcaggctgaa aatcttctct     4560

catccgccaa aacagccaag ctggatctaa aacactagct ctagctattg ttttaatgac     4620

aaatcagaac ggaatgtcat catcaaagtc catcggcggc tcgttagacg gcgctgccgg     4680

agcggactgc tgcgggcgag actgcgcgcc gccgctgaac tgattgccac cctgcggctg     4740

ctgaggctga ccccaaccgc cctgcggctg accaccaccg atattgccac ctgccggagc     4800

gccaccaccc tgacgaccac ccagcatctg catggtgccg ccaacgttca ccacgacttc     4860

tgtggtgtag cgatcctgac cggattgatc ggtccattta cgggtacgca gctgaccttc     4920

gatataaacc tgagaacctt tacgcagata ttcgctcgcc acttctgcca gtttgccgaa     4980

cagcacaacg cggtgccatt cagtctgttc tttcatctcg ccggtcgctt tatcacgcca     5040

ggattcggaa gtagccagcg taatgttggc aactgcgcca ccatttggca tgtagcgtac     5100

ttccgggtcc tgacccagat taccaacgag aataaccttg tttacgcctc tgctggccat     5160

gttcgtgtct cctgaaaaaa atcgttctga ataagtgtaa acgcgcgatt gtaccattac     5220

caatagcgct tttactatgt tgtgacctcg gttccgggaa acaaacctgg ccagacattg     5280

ttacacaaca ctccggataa tgcattccaa tactgtatat tcattcaggt caatcatatg     5340

aagggcgaat tctgcagata tccatcacac tggcggccgc cagtgtgatg gatatctgca     5400

gaattcgccc ttgagaagtt cctattctat atatagtata ggaacttctc tagaactttt     5460

gttacccgcc aaacaaaacc caaaaacaac ccatacccaa cccaataaaa caccaaaaca     5520

agacaaataa tcattgattg atggttgaaa tggggtaaac ttgacaaaca aacccactta     5580

aaacccaaaa catacccaaa cacacaccaa aaaaacacca taaggagttt tataaatgtt     5640

ggtattcatt gatgacggtt caacaaacat caaactacag tggcaggaaa gcgacggaac     5700

aattaaacag cacattagcc cgaacagctt caaacgcgag tgggcagtct cttttggtga     5760

taaaaaggtc tttaactaca cactgaacgg cgaacagtat tcatttgatc caatcagccc     5820

ggatgctgta gtcacaacca atatcgcatg gcaatacagc gacgttaatg tcgttgcagt     5880

gcatcacgcc ttactgacca gtggtctgcc ggtaagcgaa gtggatattg tttgcacact     5940

tcctctgaca gagtattacg acagaaataa ccaacccaat acggaaaata ttgagcgtaa     6000

gaaagcaaac ttccggaaaa aaattacatt aaatggcggg gatacattca caataaaaga     6060

tgtaaaagtc atgcctgaat ctataccggc aggttatgaa gttctacaag aactggatga     6120

gttagattct ttattaatta tagatctcgg gggcaccaca ttagatattt ctcaggtaat     6180

ggggaaatta tcggggatca gtaaaatata cggagactca tctcttggtg tctctctggt     6240

tacatctgca gtaaaagatg ccctttctct tgcgagaaca aaaggaagta gctatcttgc     6300

tgacgatata atcattcaca gaaaagataa taactatctg aagcaacgaa ttaatgatga     6360

gaacaaaata tcaatagtca ccgaagcaat gaatgaagca cttcgtaaac ttgagcaacg     6420

tgtattaaat acgctcaatg aattttctgg ttatactcat gttatggtta taggcggtgg     6480

cgcagaatta atatgcgatg cagtaaaaaa acacacacag attcgtgatg aacgtttttt     6540

caaaaccaat aactctcaat atgatttagt taacggtatg tatctcatag gtaattaatg     6600

atggacaagc gcagaaccat tgccttcaaa ctaaatccag atgtaaatca aacagataaa     6660

attgtttgtg atacactgga cagtatcccg caaggggaac gaagccgcct taaccgggcc     6720

gcactgacgg caggtctggc cttatacaga caagatcccc ggaccccttt ccttttatgt     6780

gagctgctga cgaaagaaac cacattttca gatatcgtga atatattgag atcgctattt     6840

ccaaaagaga tggccgattt taattcttca atagtcactc aatcctcttc acaacaagag     6900

caaaaaagtg atgaagagac caaaaaaaat gcgatgaagc taataaatta attcaattat     6960

tattgagttc cctttatcca ctatcaggct ggataaaggg aactcaatca agttattttc     7020

ttaccagtca ttacataatc gttattatga aataatcgtt tgcactgtct ctgttattca     7080

ggcaatttca ataaaggcac ttgctcacgc tctgtcattt tctgaaactc ttcatgctg      7139


<210>  12
<211>  536
<212>  PRT
<213>  artificial

<220>
<223>  synthetic

<400>  12

Met Thr Ser Gly Leu Ile Tyr Ile Asn Asp Ser Leu Tyr Tyr Phe Lys 
1               5                   10                  15      


Pro Pro Val Asn Asn Leu Ile Thr Gly Phe Val Thr Val Gly Asp Asp 
            20                  25                  30          


Lys Tyr Tyr Phe Asn Pro Ile Asn Gly Gly Ala Ala Ser Ile Gly Glu 
        35                  40                  45              


Thr Ile Ile Asp Asp Lys Asn Tyr Tyr Phe Asn Gln Ser Gly Val Leu 
    50                  55                  60                  


Gln Thr Gly Val Phe Ser Thr Glu Asp Gly Phe Lys Tyr Phe Ala Pro 
65                  70                  75                  80  


Ala Asn Thr Leu Asp Glu Asn Leu Glu Gly Glu Ala Ile Asp Phe Thr 
                85                  90                  95      


Gly Lys Leu Ile Ile Asp Glu Asn Ile Tyr Tyr Phe Asp Asp Asn Tyr 
            100                 105                 110         


Arg Gly Ala Val Glu Trp Lys Glu Leu Asp Gly Glu Met His Tyr Phe 
        115                 120                 125             


Ser Pro Glu Thr Gly Lys Ala Phe Lys Gly Leu Asn Gln Ile Gly Asp 
    130                 135                 140                 


Tyr Lys Tyr Tyr Phe Asn Ser Asp Gly Val Met Gln Lys Gly Phe Val 
145                 150                 155                 160 


Ser Ile Asn Asp Asn Lys His Tyr Phe Asp Asp Ser Gly Val Met Lys 
                165                 170                 175     


Val Gly Tyr Thr Glu Ile Asp Gly Lys His Phe Tyr Phe Ala Glu Asn 
            180                 185                 190         


Gly Glu Met Gln Ile Gly Val Phe Asn Thr Glu Asp Gly Phe Lys Tyr 
        195                 200                 205             


Phe Ala His His Asn Glu Asp Leu Gly Asn Glu Glu Gly Glu Glu Ile 
    210                 215                 220                 


Ser Tyr Ser Gly Ile Leu Asn Phe Asn Asn Lys Ile Tyr Tyr Phe Asp 
225                 230                 235                 240 


Asp Ser Phe Thr Ala Val Val Gly Trp Lys Asp Leu Glu Asp Gly Ser 
                245                 250                 255     


Lys Tyr Tyr Phe Asp Glu Asp Thr Ala Glu Ala Tyr Ile Gly Leu Ser 
            260                 265                 270         


Leu Ile Asn Asp Gly Gln Tyr Tyr Phe Asn Asp Asp Gly Ile Met Gln 
        275                 280                 285             


Val Gly Phe Val Thr Ile Asn Asp Lys Val Phe Tyr Phe Ser Asp Ser 
    290                 295                 300                 


Gly Ile Ile Glu Ser Gly Val Gln Asn Ile Asp Asp Asn Tyr Phe Tyr 
305                 310                 315                 320 


Ile Asp Asp Asn Gly Ile Val Gln Ile Gly Val Phe Asp Thr Ser Asp 
                325                 330                 335     


Gly Tyr Lys Tyr Phe Ala Pro Ala Asn Thr Val Asn Asp Asn Ile Tyr 
            340                 345                 350         


Gly Gln Ala Val Glu Tyr Ser Gly Leu Val Arg Val Gly Glu Asp Val 
        355                 360                 365             


Tyr Tyr Phe Gly Glu Thr Tyr Thr Ile Glu Thr Gly Trp Ile Tyr Asp 
    370                 375                 380                 


Met Glu Asn Glu Ser Asp Lys Tyr Tyr Phe Asn Pro Glu Thr Lys Lys 
385                 390                 395                 400 


Ala Cys Lys Gly Ile Asn Leu Ile Asp Asp Ile Lys Tyr Tyr Phe Asp 
                405                 410                 415     


Glu Lys Gly Ile Met Arg Thr Gly Leu Ile Ser Phe Glu Asn Asn Asn 
            420                 425                 430         


Tyr Tyr Phe Asn Glu Asn Gly Glu Met Gln Phe Gly Tyr Ile Asn Ile 
        435                 440                 445             


Glu Asp Lys Met Phe Tyr Phe Gly Glu Asp Gly Val Met Gln Ile Gly 
    450                 455                 460                 


Val Phe Asn Thr Pro Asp Gly Phe Lys Tyr Phe Ala His Gln Asn Thr 
465                 470                 475                 480 


Leu Asp Glu Asn Phe Glu Gly Glu Ser Ile Asn Tyr Thr Gly Trp Leu 
                485                 490                 495     


Asp Leu Asp Glu Lys Arg Tyr Tyr Phe Thr Asp Glu Tyr Ile Ala Ala 
            500                 505                 510         


Thr Gly Ser Val Ile Ile Asp Gly Glu Glu Tyr Tyr Phe Asp Pro Asp 
        515                 520                 525             


Thr Ala Gln Leu Val Ile Ser Glu 
    530                 535     


<210>  13
<211>  1102
<212>  DNA
<213>  Salmonella enterica Typhi

<400>  13
ggaggtaata ggtaagaata ctttataaaa caggtactta attgcaattt atatatttaa       60

agaggcaaat gattatgacc ggaatatttg cagaacaaac tgtagaggta gttaaaagcg      120

cgatcgaaac cgcagatggg gcattagatc tttataacaa atacctcgac caggtcatcc      180

cctggaagac ctttgatgaa accataaaag agttaagccg ttttaaacag gagtactcgc      240

aggaagcttc tgttttagtt ggtgatatta aagttttgct tatggacagc caggacaagt      300

attttgaagc gacacaaact gtttatgaat ggtgtggtgt cgtgacgcaa ttactctcag      360

cgtatatttt actatttgat gaatataatg agaaaaaagc atcagcccag aaagacattc      420

tcattaggat attagatgat ggtgtcaaga aactgaatga agcgcaaaaa tctctcctga      480

caagttcaca aagtttcaac aacgcttccg gaaaactgct ggcattagat agccagttaa      540

ctaatgattt ttcggaaaaa agtagttatt tccagtcaca ggtggataga attcgtaagg      600

aagcttatgc cggtgctgca gccggcatag tcgccggtcc gtttggatta attatttcct      660

attctattgc tgcgggcgtg attgaaggga aattgattcc agaattgaat aacaggctaa      720

aaacagtgca aaatttcttt actagcttat cagctacagt gaaacaagcg aataaagata      780

tcgatgcggc aaaattgaaa ttagccactg aaatagcagc aattggggag ataaaaacgg      840

aaaccgaaac aaccagattc tacgttgatt atgatgattt aatgctttct ttattaaaag      900

gagctgcaaa gaaaatgatt aacacctgta atgaatacca acaaagacac ggtaagaaga      960

cgcttttcga ggttcctgac gtctgataca ttttcattcg atctgtgtac ttttaacgcc     1020

cgatagcgta aagaaaatga gagacggaga aaaagcgata ttcaacagcc cgataaacaa     1080

gagtcgttac cgggctgacg ag                                              1102


<210>  14
<211>  303
<212>  PRT
<213>  Salmonella enterica Thyphi

<400>  14

Met Thr Gly Ile Phe Ala Glu Gln Thr Val Glu Val Val Lys Ser Ala 
1               5                   10                  15      


Ile Glu Thr Ala Asp Gly Ala Leu Asp Leu Tyr Asn Lys Tyr Leu Asp 
            20                  25                  30          


Gln Val Ile Pro Trp Lys Thr Phe Asp Glu Thr Ile Lys Glu Leu Ser 
        35                  40                  45              


Arg Phe Lys Gln Glu Tyr Ser Gln Glu Ala Ser Val Leu Val Gly Asp 
    50                  55                  60                  


Ile Lys Val Leu Leu Met Asp Ser Gln Asp Lys Tyr Phe Glu Ala Thr 
65                  70                  75                  80  


Gln Thr Val Tyr Glu Trp Cys Gly Val Val Thr Gln Leu Leu Ser Ala 
                85                  90                  95      


Tyr Ile Leu Leu Phe Asp Glu Tyr Asn Glu Lys Lys Ala Ser Ala Gln 
            100                 105                 110         


Lys Asp Ile Leu Ile Arg Ile Leu Asp Asp Gly Val Lys Lys Leu Asn 
        115                 120                 125             


Glu Ala Gln Lys Ser Leu Leu Thr Ser Ser Gln Ser Phe Asn Asn Ala 
    130                 135                 140                 


Ser Gly Lys Leu Leu Ala Leu Asp Ser Gln Leu Thr Asn Asp Phe Ser 
145                 150                 155                 160 


Glu Lys Ser Ser Tyr Phe Gln Ser Gln Val Asp Arg Ile Arg Lys Glu 
                165                 170                 175     


Ala Tyr Ala Gly Ala Ala Ala Gly Ile Val Ala Gly Pro Phe Gly Leu 
            180                 185                 190         


Ile Ile Ser Tyr Ser Ile Ala Ala Gly Val Ile Glu Gly Lys Leu Ile 
        195                 200                 205             


Pro Glu Leu Asn Asn Arg Leu Lys Thr Val Gln Asn Phe Phe Thr Ser 
    210                 215                 220                 


Leu Ser Ala Thr Val Lys Gln Ala Asn Lys Asp Ile Asp Ala Ala Lys 
225                 230                 235                 240 


Leu Lys Leu Ala Thr Glu Ile Ala Ala Ile Gly Glu Ile Lys Thr Glu 
                245                 250                 255     


Thr Glu Thr Thr Arg Phe Tyr Val Asp Tyr Asp Asp Leu Met Leu Ser 
            260                 265                 270         


Leu Leu Lys Gly Ala Ala Lys Lys Met Ile Asn Thr Cys Asn Glu Tyr 
        275                 280                 285             


Gln Gln Arg His Gly Lys Lys Thr Leu Phe Glu Val Pro Asp Val 
    290                 295                 300             


<210>  15
<211>  879
<212>  PRT
<213>  Clostridium difficile

<400>  15

Gly Leu Ile Asn Ile Asn Asn Ser Leu Phe Tyr Phe Asp Pro Ile Glu 
1               5                   10                  15      


Phe Asn Leu Val Thr Gly Trp Gln Thr Ile Asn Gly Lys Lys Tyr Tyr 
            20                  25                  30          


Phe Asp Ile Asn Thr Gly Ala Ala Leu Thr Ser Tyr Lys Ile Ile Asn 
        35                  40                  45              


Gly Lys His Phe Tyr Phe Asn Asn Asp Gly Val Met Gln Leu Gly Val 
    50                  55                  60                  


Phe Lys Gly Pro Asp Gly Phe Glu Tyr Phe Ala Pro Ala Asn Thr Gln 
65                  70                  75                  80  


Asn Asn Asn Ile Glu Gly Gln Ala Ile Val Tyr Gln Ser Lys Phe Leu 
                85                  90                  95      


Thr Leu Asn Gly Lys Lys Tyr Tyr Phe Asp Asn Asn Ser Lys Ala Val 
            100                 105                 110         


Thr Gly Trp Arg Ile Ile Asn Asn Glu Lys Tyr Tyr Phe Asn Pro Asn 
        115                 120                 125             


Asn Ala Ile Ala Ala Val Gly Leu Gln Val Ile Asp Asn Asn Lys Tyr 
    130                 135                 140                 


Tyr Phe Asn Pro Asp Thr Ala Ile Ile Ser Lys Gly Trp Gln Thr Val 
145                 150                 155                 160 


Asn Gly Ser Arg Tyr Tyr Phe Asp Thr Asp Thr Ala Ile Ala Phe Asn 
                165                 170                 175     


Gly Tyr Lys Thr Ile Asp Gly Lys His Phe Tyr Phe Asp Ser Asp Cys 
            180                 185                 190         


Val Val Lys Ile Gly Val Phe Ser Thr Ser Asn Gly Phe Glu Tyr Phe 
        195                 200                 205             


Ala Pro Ala Asn Thr Tyr Asn Asn Asn Ile Glu Gly Gln Ala Ile Val 
    210                 215                 220                 


Tyr Gln Ser Lys Phe Leu Thr Leu Asn Gly Lys Lys Tyr Tyr Phe Asp 
225                 230                 235                 240 


Asn Asn Ser Lys Ala Val Thr Gly Leu Gln Thr Ile Asp Ser Lys Lys 
                245                 250                 255     


Tyr Tyr Phe Asn Thr Asn Thr Ala Glu Ala Ala Thr Gly Trp Gln Thr 
            260                 265                 270         


Ile Asp Gly Lys Lys Tyr Tyr Phe Asn Thr Asn Thr Ala Glu Ala Ala 
        275                 280                 285             


Thr Gly Trp Gln Thr Ile Asp Gly Lys Lys Tyr Tyr Phe Asn Thr Asn 
    290                 295                 300                 


Thr Ala Ile Ala Ser Thr Gly Tyr Thr Ile Ile Asn Gly Lys His Phe 
305                 310                 315                 320 


Tyr Phe Asn Thr Asp Gly Ile Met Gln Ile Gly Val Phe Lys Gly Pro 
                325                 330                 335     


Asn Gly Phe Glu Tyr Phe Ala Pro Ala Asn Thr Asp Ala Asn Asn Ile 
            340                 345                 350         


Glu Gly Gln Ala Ile Leu Tyr Gln Asn Glu Phe Leu Thr Leu Asn Gly 
        355                 360                 365             


Lys Lys Tyr Tyr Phe Gly Ser Asp Ser Lys Ala Val Thr Gly Trp Arg 
    370                 375                 380                 


Ile Ile Asn Asn Lys Lys Tyr Tyr Phe Asn Pro Asn Asn Ala Ile Ala 
385                 390                 395                 400 


Ala Ile His Leu Cys Thr Ile Asn Asn Asp Lys Tyr Tyr Phe Ser Tyr 
                405                 410                 415     


Asp Gly Ile Leu Gln Asn Gly Tyr Ile Thr Ile Glu Arg Asn Asn Phe 
            420                 425                 430         


Tyr Phe Asp Ala Asn Asn Glu Ser Lys Met Val Thr Gly Val Phe Lys 
        435                 440                 445             


Gly Pro Asn Gly Phe Glu Tyr Phe Ala Pro Ala Asn Thr His Asn Asn 
    450                 455                 460                 


Asn Ile Glu Gly Gln Ala Ile Val Tyr Gln Asn Lys Phe Leu Thr Leu 
465                 470                 475                 480 


Asn Gly Lys Lys Tyr Tyr Phe Asp Asn Asp Ser Lys Ala Val Thr Gly 
                485                 490                 495     


Trp Gln Thr Ile Asp Gly Lys Lys Tyr Tyr Phe Asn Leu Asn Thr Ala 
            500                 505                 510         


Glu Ala Ala Thr Gly Trp Gln Thr Ile Asp Gly Lys Lys Tyr Tyr Phe 
        515                 520                 525             


Asn Leu Asn Thr Ala Glu Ala Ala Thr Gly Trp Gln Thr Ile Asp Gly 
    530                 535                 540                 


Lys Lys Tyr Tyr Phe Asn Thr Asn Thr Phe Ile Ala Ser Thr Gly Tyr 
545                 550                 555                 560 


Thr Ser Ile Asn Gly Lys His Phe Tyr Phe Asn Thr Asp Gly Ile Met 
                565                 570                 575     


Gln Ile Gly Val Phe Lys Gly Pro Asn Gly Phe Glu Tyr Phe Ala Pro 
            580                 585                 590         


Ala Asn Thr Asp Ala Asn Asn Ile Glu Gly Gln Ala Ile Leu Tyr Gln 
        595                 600                 605             


Asn Lys Phe Leu Thr Leu Asn Gly Lys Lys Tyr Tyr Phe Gly Ser Asp 
    610                 615                 620                 


Ser Lys Ala Val Thr Gly Leu Arg Thr Ile Asp Gly Lys Lys Tyr Tyr 
625                 630                 635                 640 


Phe Asn Thr Asn Thr Ala Val Ala Val Thr Gly Trp Gln Thr Ile Asn 
                645                 650                 655     


Gly Lys Lys Tyr Tyr Phe Asn Thr Asn Thr Ser Ile Ala Ser Thr Gly 
            660                 665                 670         


Tyr Thr Ile Ile Ser Gly Lys His Phe Tyr Phe Asn Thr Asp Gly Ile 
        675                 680                 685             


Met Gln Ile Gly Val Phe Lys Gly Pro Asp Gly Phe Glu Tyr Phe Ala 
    690                 695                 700                 


Pro Ala Asn Thr Asp Ala Asn Asn Ile Glu Gly Gln Ala Ile Arg Tyr 
705                 710                 715                 720 


Gln Asn Arg Phe Leu Tyr Leu His Asp Asn Ile Tyr Tyr Phe Gly Asn 
                725                 730                 735     


Asn Ser Lys Ala Ala Thr Gly Trp Val Thr Ile Asp Gly Asn Arg Tyr 
            740                 745                 750         


Tyr Phe Glu Pro Asn Thr Ala Met Gly Ala Asn Gly Tyr Lys Thr Ile 
        755                 760                 765             


Asp Asn Lys Asn Phe Tyr Phe Arg Asn Gly Leu Pro Gln Ile Gly Val 
    770                 775                 780                 


Phe Lys Gly Ser Asn Gly Phe Glu Tyr Phe Ala Pro Ala Asn Thr Asp 
785                 790                 795                 800 


Ala Asn Asn Ile Glu Gly Gln Ala Ile Arg Tyr Gln Asn Arg Phe Leu 
                805                 810                 815     


His Leu Leu Gly Lys Ile Tyr Tyr Phe Gly Asn Asn Ser Lys Ala Val 
            820                 825                 830         


Thr Gly Trp Gln Thr Ile Asn Gly Lys Val Tyr Tyr Phe Met Pro Asp 
        835                 840                 845             


Thr Ala Met Ala Ala Ala Gly Gly Leu Phe Glu Ile Asp Gly Val Ile 
    850                 855                 860                 


Tyr Phe Phe Gly Val Asp Gly Val Lys Ala Pro Gly Ile Tyr Gly 
865                 870                 875                 


<210>  16
<211>  879
<212>  PRT
<213>  Clostridium difficile

<400>  16

Gly Leu Ile Asn Ile Asn Asn Ser Leu Phe Tyr Phe Asp Pro Ile Glu 
1               5                   10                  15      


Ser Asn Leu Val Thr Gly Trp Gln Thr Ile Asn Gly Lys Lys Tyr Tyr 
            20                  25                  30          


Phe Asp Ile Asn Thr Gly Ala Ala Ser Thr Ser Tyr Lys Ile Ile Asn 
        35                  40                  45              


Gly Lys His Phe Tyr Phe Asn Asn Asn Gly Val Met Gln Leu Gly Val 
    50                  55                  60                  


Phe Lys Gly Pro Asp Gly Phe Glu Tyr Phe Ala Pro Ala Asn Thr Gln 
65                  70                  75                  80  


Asn Asn Asn Ile Glu Gly Gln Ala Ile Val Tyr Gln Ser Lys Phe Leu 
                85                  90                  95      


Thr Leu Asn Gly Lys Lys Tyr Tyr Phe Asp Asn Asp Ser Lys Ala Val 
            100                 105                 110         


Thr Gly Trp Arg Ile Ile Asn Asn Glu Lys Tyr Tyr Phe Asn Pro Asn 
        115                 120                 125             


Asn Ala Ile Ala Ala Val Gly Leu Gln Val Ile Asp Asn Asn Lys Tyr 
    130                 135                 140                 


Tyr Phe Asn Pro Asp Thr Ala Ile Ile Ser Lys Gly Trp Gln Thr Val 
145                 150                 155                 160 


Asn Gly Ser Arg Tyr Tyr Phe Asp Thr Asp Thr Ala Ile Ala Phe Asn 
                165                 170                 175     


Gly Tyr Lys Thr Ile Asp Gly Lys His Phe Tyr Phe Asp Ser Asp Cys 
            180                 185                 190         


Val Val Lys Ile Gly Val Phe Ser Gly Ser Asn Gly Phe Glu Tyr Phe 
        195                 200                 205             


Ala Pro Ala Asn Thr Tyr Asn Asn Asn Ile Glu Gly Gln Ala Ile Val 
    210                 215                 220                 


Tyr Gln Ser Lys Phe Leu Thr Leu Asn Gly Lys Lys Tyr Tyr Phe Asp 
225                 230                 235                 240 


Asn Asn Ser Lys Ala Val Thr Gly Trp Gln Thr Ile Asp Ser Lys Lys 
                245                 250                 255     


Tyr Tyr Phe Asn Thr Asn Thr Ala Glu Ala Ala Thr Gly Trp Gln Thr 
            260                 265                 270         


Ile Asp Gly Lys Lys Tyr Tyr Phe Asn Thr Asn Thr Ala Glu Ala Ala 
        275                 280                 285             


Thr Gly Trp Gln Thr Ile Asp Gly Lys Lys Tyr Tyr Phe Asn Thr Asn 
    290                 295                 300                 


Thr Ser Ile Ala Ser Thr Gly Tyr Thr Ile Ile Asn Gly Lys Tyr Phe 
305                 310                 315                 320 


Tyr Phe Asn Thr Asp Gly Ile Met Gln Ile Gly Val Phe Lys Val Pro 
                325                 330                 335     


Asn Gly Phe Glu Tyr Phe Ala Pro Ala Asn Thr His Asn Asn Asn Ile 
            340                 345                 350         


Glu Gly Gln Ala Ile Leu Tyr Gln Asn Lys Phe Leu Thr Leu Asn Gly 
        355                 360                 365             


Lys Lys Tyr Tyr Phe Gly Ser Asp Ser Lys Ala Ile Thr Gly Trp Gln 
    370                 375                 380                 


Thr Ile Asp Gly Lys Lys Tyr Tyr Phe Asn Pro Asn Asn Ala Ile Ala 
385                 390                 395                 400 


Ala Thr His Leu Cys Thr Ile Asn Asn Asp Lys Tyr Tyr Phe Ser Tyr 
                405                 410                 415     


Asp Gly Ile Leu Gln Asn Gly Tyr Ile Thr Ile Glu Arg Asn Asn Phe 
            420                 425                 430         


Tyr Phe Asp Ala Asn Asn Glu Ser Lys Met Val Thr Gly Val Phe Lys 
        435                 440                 445             


Gly Pro Asn Gly Phe Glu Tyr Phe Ala Pro Ala Asn Thr His Asn Asn 
    450                 455                 460                 


Asn Ile Glu Gly Gln Ala Ile Val Tyr Gln Asn Lys Phe Leu Thr Leu 
465                 470                 475                 480 


Asn Gly Lys Lys Tyr Tyr Phe Asp Asn Asp Ser Lys Ala Val Thr Gly 
                485                 490                 495     


Trp Gln Thr Ile Asp Ser Lys Lys Tyr Tyr Phe Asn Leu Asn Thr Ala 
            500                 505                 510         


Val Ala Val Thr Gly Trp Gln Thr Ile Asp Gly Glu Lys Tyr Tyr Phe 
        515                 520                 525             


Asn Leu Asn Thr Ala Glu Ala Ala Thr Gly Trp Gln Thr Ile Asp Gly 
    530                 535                 540                 


Lys Arg Tyr Tyr Phe Asn Thr Asn Thr Tyr Ile Ala Ser Thr Gly Tyr 
545                 550                 555                 560 


Thr Ile Ile Asn Gly Lys His Phe Tyr Phe Asn Thr Asp Gly Ile Met 
                565                 570                 575     


Gln Ile Gly Val Phe Lys Gly Pro Asp Gly Phe Glu Tyr Phe Ala Pro 
            580                 585                 590         


Ala Asn Thr His Asn Asn Asn Ile Glu Gly Gln Ala Ile Leu Tyr Gln 
        595                 600                 605             


Asn Lys Phe Leu Thr Leu Asn Gly Lys Lys Tyr Tyr Phe Gly Ser Asp 
    610                 615                 620                 


Ser Lys Ala Val Thr Gly Leu Arg Thr Ile Asp Gly Lys Lys Tyr Tyr 
625                 630                 635                 640 


Phe Asn Thr Asn Thr Ala Val Ala Val Thr Gly Trp Gln Thr Ile Asn 
                645                 650                 655     


Gly Lys Lys Tyr Tyr Phe Asn Thr Asn Thr Tyr Ile Ala Ser Thr Gly 
            660                 665                 670         


Tyr Thr Ile Ile Ser Gly Lys His Phe Tyr Phe Asn Thr Asp Gly Ile 
        675                 680                 685             


Met Gln Ile Gly Val Phe Lys Gly Pro Asp Gly Phe Glu Tyr Phe Ala 
    690                 695                 700                 


Pro Ala Asn Thr Asp Ala Asn Asn Ile Glu Gly Gln Ala Ile Arg Tyr 
705                 710                 715                 720 


Gln Asn Arg Phe Leu Tyr Leu His Asp Asn Ile Tyr Tyr Phe Gly Asn 
                725                 730                 735     


Asp Ser Lys Ala Ala Thr Gly Trp Ala Thr Ile Asp Gly Asn Arg Tyr 
            740                 745                 750         


Tyr Phe Glu Pro Asn Thr Ala Met Gly Ala Asn Gly Tyr Lys Thr Ile 
        755                 760                 765             


Asp Asn Lys Asn Phe Tyr Phe Arg Asn Gly Leu Pro Gln Ile Gly Val 
    770                 775                 780                 


Phe Lys Gly Pro Asn Gly Phe Glu Tyr Phe Ala Pro Ala Asn Thr Asp 
785                 790                 795                 800 


Ala Asn Asn Ile Asp Gly Gln Ala Ile Arg Tyr Gln Asn Arg Phe Leu 
                805                 810                 815     


His Leu Leu Gly Lys Ile Tyr Tyr Phe Gly Asn Asn Ser Lys Ala Val 
            820                 825                 830         


Thr Gly Trp Gln Thr Ile Asn Ser Lys Val Tyr Tyr Phe Met Pro Asp 
        835                 840                 845             


Thr Ala Met Ala Ala Ala Gly Gly Leu Phe Glu Ile Asp Gly Val Ile 
    850                 855                 860                 


Tyr Phe Phe Gly Val Asp Gly Val Lys Ala Pro Gly Ile Tyr Gly 
865                 870                 875                 


<210>  17
<211>  879
<212>  PRT
<213>  Clostridium difficile

<400>  17

Gly Leu Ile Asn Ile Asn Asn Ser Leu Phe Tyr Phe Asp Pro Ile Glu 
1               5                   10                  15      


Phe Asn Leu Val Thr Gly Trp Gln Thr Ile Asn Gly Lys Lys Tyr Tyr 
            20                  25                  30          


Phe Asp Ile Asn Thr Gly Ala Ala Leu Ile Ser Tyr Lys Ile Ile Asn 
        35                  40                  45              


Gly Lys His Phe Tyr Phe Asn Asn Asp Gly Val Met Gln Leu Gly Val 
    50                  55                  60                  


Phe Lys Gly Pro Asp Gly Phe Glu Tyr Phe Ala Pro Ala Asn Thr Gln 
65                  70                  75                  80  


Asn Asn Asn Ile Glu Gly Gln Ala Ile Val Tyr Gln Ser Lys Phe Leu 
                85                  90                  95      


Thr Leu Asn Gly Lys Lys Tyr Tyr Phe Asp Asn Asp Ser Lys Ala Val 
            100                 105                 110         


Thr Gly Trp Arg Ile Ile Asn Asn Glu Lys Tyr Tyr Phe Asn Pro Asn 
        115                 120                 125             


Asn Ala Ile Ala Ala Val Gly Leu Gln Val Ile Asp Asn Asn Lys Tyr 
    130                 135                 140                 


Tyr Phe Asn Pro Asp Thr Ala Ile Ile Ser Lys Gly Trp Gln Thr Val 
145                 150                 155                 160 


Asn Gly Ser Arg Tyr Tyr Phe Asp Thr Asp Thr Ala Ile Ala Phe Asn 
                165                 170                 175     


Gly Tyr Lys Thr Ile Asp Gly Lys His Phe Tyr Phe Asp Ser Asp Cys 
            180                 185                 190         


Val Val Lys Ile Gly Val Phe Ser Thr Ser Asn Gly Phe Glu Tyr Phe 
        195                 200                 205             


Ala Pro Ala Asn Thr Tyr Asn Asn Asn Ile Glu Gly Gln Ala Ile Val 
    210                 215                 220                 


Tyr Gln Ser Lys Phe Leu Thr Leu Asn Gly Lys Lys Tyr Tyr Phe Asp 
225                 230                 235                 240 


Asn Asn Ser Lys Ala Val Thr Gly Trp Gln Thr Ile Asp Ser Lys Lys 
                245                 250                 255     


Tyr Tyr Phe Asn Thr Asn Thr Ala Glu Ala Ala Thr Gly Trp Gln Thr 
            260                 265                 270         


Ile Asp Gly Lys Lys Tyr Tyr Phe Asn Thr Asn Thr Ala Glu Ala Ala 
        275                 280                 285             


Thr Gly Trp Gln Thr Ile Asp Gly Lys Lys Tyr Tyr Phe Asn Thr Asn 
    290                 295                 300                 


Thr Ala Ile Ala Ser Thr Gly Tyr Thr Ile Ile Asn Gly Lys His Phe 
305                 310                 315                 320 


Tyr Phe Asn Thr Asp Gly Ile Met Gln Ile Gly Val Phe Lys Gly Pro 
                325                 330                 335     


Asn Gly Phe Glu Tyr Phe Ala Pro Ala Asn Thr Asp Ala Asn Asn Ile 
            340                 345                 350         


Glu Gly Gln Ala Ile Leu Tyr Gln Asn Glu Phe Leu Thr Leu Asn Gly 
        355                 360                 365             


Lys Lys Tyr Tyr Phe Gly Ser Asp Ser Lys Ala Val Thr Gly Trp Arg 
    370                 375                 380                 


Ile Ile Asn Asn Lys Lys Tyr Tyr Phe Asn Pro Asn Asn Ala Ile Ala 
385                 390                 395                 400 


Ala Ile His Leu Cys Thr Ile Asn Asn Asp Lys Tyr Tyr Phe Ser Tyr 
                405                 410                 415     


Asp Gly Ile Leu Gln Asn Gly Tyr Ile Thr Ile Glu Arg Asn Asn Phe 
            420                 425                 430         


Tyr Phe Asp Ala Asn Asn Glu Ser Lys Met Val Thr Gly Val Phe Lys 
        435                 440                 445             


Gly Pro Asn Gly Phe Glu Tyr Phe Ala Pro Ala Asn Thr His Asn Asn 
    450                 455                 460                 


Asn Ile Glu Gly Gln Ala Ile Val Tyr Gln Asn Lys Phe Leu Thr Leu 
465                 470                 475                 480 


Asn Gly Lys Lys Tyr Tyr Phe Asp Asn Asp Ser Lys Ala Val Thr Gly 
                485                 490                 495     


Trp Gln Thr Ile Asp Gly Lys Lys Tyr Tyr Phe Asn Leu Asn Thr Ala 
            500                 505                 510         


Glu Ala Ala Thr Gly Trp Gln Thr Ile Asp Gly Lys Lys Tyr Tyr Phe 
        515                 520                 525             


Asn Leu Asn Thr Ala Glu Ala Ala Thr Gly Trp Gln Thr Ile Asp Gly 
    530                 535                 540                 


Lys Lys Tyr Tyr Phe Asn Thr Asn Thr Phe Ile Ala Ser Thr Gly Tyr 
545                 550                 555                 560 


Thr Ser Ile Asn Gly Lys His Phe Tyr Phe Asn Thr Asp Gly Ile Met 
                565                 570                 575     


Gln Ile Gly Val Phe Lys Gly Pro Asn Gly Phe Glu Tyr Phe Ala Pro 
            580                 585                 590         


Ala Asn Thr His Asn Asn Asn Ile Glu Gly Gln Ala Ile Leu Tyr Gln 
        595                 600                 605             


Asn Lys Phe Leu Thr Leu Asn Gly Lys Lys Tyr Tyr Phe Gly Ser Asp 
    610                 615                 620                 


Ser Lys Ala Val Thr Gly Leu Arg Thr Ile Asp Gly Lys Lys Tyr Tyr 
625                 630                 635                 640 


Phe Asn Thr Asn Thr Ala Val Ala Val Thr Gly Trp Gln Thr Ile Asn 
                645                 650                 655     


Gly Lys Lys Tyr Tyr Phe Asn Thr Asn Thr Ser Ile Ala Ser Thr Gly 
            660                 665                 670         


Tyr Thr Ile Ile Ser Gly Lys His Phe Tyr Phe Asn Thr Asp Gly Ile 
        675                 680                 685             


Met Gln Ile Gly Val Phe Lys Gly Pro Asp Gly Phe Glu Tyr Phe Ala 
    690                 695                 700                 


Pro Ala Asn Thr Asp Ala Asn Asn Ile Glu Gly Gln Ala Ile Arg Tyr 
705                 710                 715                 720 


Gln Asn Arg Phe Leu Tyr Leu His Asp Asn Ile Tyr Tyr Phe Gly Asn 
                725                 730                 735     


Asn Ser Lys Ala Ala Thr Gly Trp Val Thr Ile Asp Gly Asn Arg Tyr 
            740                 745                 750         


Tyr Phe Glu Pro Asn Thr Ala Met Gly Ala Asn Gly Tyr Lys Thr Ile 
        755                 760                 765             


Asp Asn Lys Asn Phe Tyr Phe Arg Asn Gly Leu Pro Gln Ile Gly Val 
    770                 775                 780                 


Phe Lys Gly Ser Asn Gly Phe Glu Tyr Phe Ala Pro Ala Asn Thr Asp 
785                 790                 795                 800 


Ala Asn Asn Ile Glu Gly Gln Ala Ile Arg Tyr Gln Asn Arg Phe Leu 
                805                 810                 815     


His Leu Leu Gly Lys Ile Tyr Tyr Phe Gly Asn Asn Ser Lys Ala Val 
            820                 825                 830         


Thr Gly Trp Gln Thr Ile Asn Gly Lys Val Tyr Tyr Phe Met Pro Asp 
        835                 840                 845             


Thr Ala Met Ala Ala Ala Gly Gly Leu Phe Glu Ile Asp Gly Val Ile 
    850                 855                 860                 


Tyr Phe Phe Gly Val Asp Gly Val Lys Ala Pro Gly Ile Tyr Gly 
865                 870                 875                 


<210>  18
<211>  533
<212>  PRT
<213>  Clostridium difficile

<400>  18

Gly Leu Val Tyr Ile Asn Asp Ser Leu Tyr Tyr Phe Lys Pro Pro Ile 
1               5                   10                  15      


Lys Asn Leu Ile Thr Gly Phe Thr Thr Ile Gly Asp Asp Lys Tyr Tyr 
            20                  25                  30          


Phe Asn Pro Asp Asn Gly Gly Ala Ala Ser Val Gly Glu Thr Ile Ile 
        35                  40                  45              


Asp Gly Lys Asn Tyr Tyr Phe Ser Gln Asn Gly Val Leu Gln Thr Gly 
    50                  55                  60                  


Val Phe Ser Thr Glu Asp Gly Phe Lys Tyr Phe Ala Pro Ala Asp Thr 
65                  70                  75                  80  


Leu Asp Glu Asn Leu Glu Gly Glu Ala Ile Asp Phe Thr Gly Lys Leu 
                85                  90                  95      


Thr Ile Asp Glu Asn Val Tyr Tyr Phe Gly Asp Asn Tyr Arg Ala Ala 
            100                 105                 110         


Ile Glu Trp Gln Thr Leu Asp Asp Glu Val Tyr Tyr Phe Ser Thr Asp 
        115                 120                 125             


Thr Gly Arg Ala Phe Lys Gly Leu Asn Gln Ile Gly Asp Asp Lys Phe 
    130                 135                 140                 


Tyr Phe Asn Ser Asp Gly Ile Met Gln Lys Gly Phe Val Asn Ile Asn 
145                 150                 155                 160 


Asp Lys Thr Phe Tyr Phe Asp Asp Ser Gly Val Met Lys Ser Gly Tyr 
                165                 170                 175     


Thr Glu Ile Asp Gly Lys Tyr Phe Tyr Phe Ala Glu Asn Gly Glu Met 
            180                 185                 190         


Gln Ile Gly Val Phe Asn Thr Ala Asp Gly Phe Lys Tyr Phe Ala His 
        195                 200                 205             


His Asp Glu Asp Leu Gly Asn Glu Glu Gly Glu Ala Leu Ser Tyr Ser 
    210                 215                 220                 


Gly Ile Leu Asn Phe Asn Asn Lys Ile Tyr Tyr Phe Asp Asp Ser Phe 
225                 230                 235                 240 


Thr Ala Val Val Gly Trp Lys Asp Leu Glu Asp Gly Ser Lys Tyr Tyr 
                245                 250                 255     


Phe Asp Glu Asp Thr Ala Glu Ala Tyr Ile Gly Ile Ser Ile Ile Asn 
            260                 265                 270         


Asp Gly Lys Tyr Tyr Phe Asn Asp Ser Gly Ile Met Gln Ile Gly Phe 
        275                 280                 285             


Val Thr Ile Asn Asn Glu Val Phe Tyr Phe Ser Asp Ser Gly Ile Val 
    290                 295                 300                 


Glu Ser Gly Met Gln Asn Ile Asp Asp Asn Tyr Phe Tyr Ile Asp Glu 
305                 310                 315                 320 


Asn Gly Leu Val Gln Ile Gly Val Phe Asp Thr Ser Asp Gly Tyr Lys 
                325                 330                 335     


Tyr Phe Ala Pro Ala Asn Thr Val Asn Asp Asn Ile Tyr Gly Gln Ala 
            340                 345                 350         


Val Glu Tyr Ser Gly Leu Val Arg Val Gly Glu Asp Val Tyr Tyr Phe 
        355                 360                 365             


Gly Glu Thr Tyr Thr Ile Glu Thr Gly Trp Ile Tyr Asp Met Glu Asn 
    370                 375                 380                 


Glu Ser Asp Lys Tyr Tyr Phe Asp Pro Glu Thr Lys Lys Ala Tyr Lys 
385                 390                 395                 400 


Gly Ile Asn Val Ile Asp Asp Ile Lys Tyr Tyr Phe Asp Glu Asn Gly 
                405                 410                 415     


Ile Met Arg Thr Gly Leu Ile Thr Phe Glu Asp Asn His Tyr Tyr Phe 
            420                 425                 430         


Asn Glu Asp Gly Ile Met Gln Tyr Gly Tyr Leu Asn Ile Glu Asp Lys 
        435                 440                 445             


Thr Phe Tyr Phe Ser Glu Asp Gly Ile Met Gln Ile Gly Val Phe Asn 
    450                 455                 460                 


Thr Pro Asp Gly Phe Lys Tyr Phe Ala His Gln Asn Thr Leu Asp Glu 
465                 470                 475                 480 


Asn Phe Glu Gly Glu Ser Ile Asn Tyr Thr Gly Trp Leu Asp Leu Asp 
                485                 490                 495     


Glu Lys Arg Tyr Tyr Phe Thr Asp Glu Tyr Ile Ala Ala Thr Gly Ser 
            500                 505                 510         


Val Ile Ile Asp Gly Glu Glu Tyr Tyr Phe Asp Pro Asp Thr Ala Gln 
        515                 520                 525             


Leu Val Ile Ser Glu 
    530             


<210>  19
<211>  533
<212>  PRT
<213>  Clostridium difficile

<400>  19

Gly Leu Ile Tyr Ile Asn Asp Ser Leu Tyr Tyr Phe Lys Pro Pro Val 
1               5                   10                  15      


Asn Asn Leu Ile Thr Gly Phe Val Thr Val Gly Asp Asp Lys Tyr Tyr 
            20                  25                  30          


Phe Asn Pro Ile Asn Gly Gly Ala Ala Ser Ile Gly Glu Thr Ile Ile 
        35                  40                  45              


Asp Asp Lys Asn Tyr Tyr Phe Asn Gln Ser Gly Val Leu Gln Thr Gly 
    50                  55                  60                  


Val Phe Ser Thr Glu Asp Gly Phe Lys Tyr Phe Ala Pro Ala Asn Thr 
65                  70                  75                  80  


Leu Asp Glu Asn Leu Glu Gly Glu Ala Ile Asp Phe Thr Gly Lys Leu 
                85                  90                  95      


Ile Ile Asp Glu Asn Ile Tyr Tyr Phe Asp Asp Asn Tyr Arg Gly Ala 
            100                 105                 110         


Val Glu Trp Lys Glu Leu Asp Gly Glu Met His Tyr Phe Ser Pro Glu 
        115                 120                 125             


Thr Gly Lys Ala Phe Lys Gly Leu Asn Gln Ile Gly Asp Tyr Lys Tyr 
    130                 135                 140                 


Tyr Phe Asn Ser Asp Gly Val Met Gln Lys Gly Phe Val Ser Ile Asn 
145                 150                 155                 160 


Asp Asn Lys His Tyr Phe Asp Asp Ser Gly Val Met Lys Val Gly Tyr 
                165                 170                 175     


Thr Glu Ile Asp Gly Lys His Phe Tyr Phe Ala Glu Asn Gly Glu Met 
            180                 185                 190         


Gln Ile Gly Val Phe Asn Thr Glu Asp Gly Phe Lys Tyr Phe Ala His 
        195                 200                 205             


His Asn Glu Asp Leu Gly Asn Glu Glu Gly Glu Glu Ile Ser Tyr Ser 
    210                 215                 220                 


Gly Ile Leu Asn Phe Asn Asn Lys Ile Tyr Tyr Phe Asp Asp Ser Phe 
225                 230                 235                 240 


Thr Ala Val Val Gly Trp Lys Asp Leu Glu Asp Gly Ser Lys Tyr Tyr 
                245                 250                 255     


Phe Asp Glu Asp Thr Ala Glu Ala Tyr Ile Gly Leu Ser Leu Ile Asn 
            260                 265                 270         


Asp Gly Gln Tyr Tyr Phe Asn Asp Asp Gly Ile Met Gln Val Gly Phe 
        275                 280                 285             


Val Thr Ile Asn Asp Lys Val Phe Tyr Phe Ser Asp Ser Gly Ile Ile 
    290                 295                 300                 


Glu Ser Gly Val Gln Asn Ile Asp Asp Asn Tyr Phe Tyr Ile Asp Asp 
305                 310                 315                 320 


Asn Gly Ile Val Gln Ile Gly Val Phe Asp Thr Ser Asp Gly Tyr Lys 
                325                 330                 335     


Tyr Phe Ala Pro Ala Asn Thr Val Asn Asp Asn Ile Tyr Gly Gln Ala 
            340                 345                 350         


Val Glu Tyr Ser Gly Leu Val Arg Val Gly Glu Asp Val Tyr Tyr Phe 
        355                 360                 365             


Gly Glu Thr Tyr Thr Ile Glu Thr Gly Trp Ile Tyr Asp Met Glu Asn 
    370                 375                 380                 


Glu Ser Asp Lys Tyr Tyr Phe Asn Pro Glu Thr Lys Lys Ala Cys Lys 
385                 390                 395                 400 


Gly Ile Asn Leu Ile Asp Asp Ile Lys Tyr Tyr Phe Asp Glu Lys Gly 
                405                 410                 415     


Ile Met Arg Thr Gly Leu Ile Ser Phe Glu Asn Asn Asn Tyr Tyr Phe 
            420                 425                 430         


Asn Glu Asn Gly Glu Met Gln Phe Gly Tyr Ile Asn Ile Glu Asp Lys 
        435                 440                 445             


Met Phe Tyr Phe Gly Glu Asp Gly Val Met Gln Ile Gly Val Phe Asn 
    450                 455                 460                 


Thr Pro Asp Gly Phe Lys Tyr Phe Ala His Gln Asn Thr Leu Asp Glu 
465                 470                 475                 480 


Asn Phe Glu Gly Glu Ser Ile Asn Tyr Thr Gly Trp Leu Asp Leu Asp 
                485                 490                 495     


Glu Lys Arg Tyr Tyr Phe Thr Asp Glu Tyr Ile Ala Ala Thr Gly Ser 
            500                 505                 510         


Val Ile Ile Asp Gly Glu Glu Tyr Tyr Phe Asp Pro Asp Thr Ala Gln 
        515                 520                 525             


Leu Val Ile Ser Glu 
    530             


