                         SEQUENCE LISTING

<110>  Talecris Biotherapeutics, Inc.
       Barnett, Thomas
 
<120>  COMPOSITIONS, METHODS, AND KITS

<130>  T126 2110PCT

<150>  61/261,145
<151>  2009-11-13

<160>  43    

<170>  PatentIn version 3.5

<210>  1
<211>  484
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  sequence

<400>  1

Ser Leu Ser Cys Arg Pro Pro Met Val Lys Leu Val Cys Pro Ala Asp 
1               5                   10                  15      


Asn Leu Arg Ala Glu Gly Leu Glu Cys Thr Lys Thr Cys Gln Asn Tyr 
            20                  25                  30          


Asp Leu Glu Cys Met Ser Met Gly Cys Val Ser Gly Cys Leu Cys Pro 
        35                  40                  45              


Pro Gly Met Val Arg His Glu Asn Arg Cys Val Ala Leu Glu Arg Cys 
    50                  55                  60                  


Pro Cys Phe His Gln Gly Lys Glu Tyr Ala Pro Gly Glu Thr Val Lys 
65                  70                  75                  80  


Ile Gly Cys Asn Thr Cys Val Cys Arg Asp Arg Lys Trp Asn Cys Thr 
                85                  90                  95      


Asp His Val Cys Asp Ala Thr Cys Ser Thr Ile Gly Met Ala His Tyr 
            100                 105                 110         


Leu Thr Phe Asp Gly Leu Lys Tyr Leu Phe Pro Gly Glu Cys Gln Tyr 
        115                 120                 125             


Val Leu Val Gln Asp Tyr Cys Gly Ser Asn Pro Gly Thr Phe Arg Ile 
    130                 135                 140                 


Leu Val Gly Asn Lys Gly Cys Ser His Pro Ser Val Lys Cys Lys Lys 
145                 150                 155                 160 


Arg Val Thr Ile Leu Val Glu Gly Gly Glu Ile Glu Leu Phe Asp Gly 
                165                 170                 175     


Glu Val Asn Val Lys Arg Pro Met Lys Asp Glu Thr His Phe Glu Val 
            180                 185                 190         


Val Glu Ser Gly Arg Tyr Ile Ile Leu Leu Leu Gly Lys Ala Leu Ser 
        195                 200                 205             


Val Val Trp Asp Arg His Leu Ser Ile Ser Val Val Leu Lys Gln Thr 
    210                 215                 220                 


Tyr Gln Glu Lys Val Cys Gly Leu Cys Gly Asn Phe Asp Gly Ile Gln 
225                 230                 235                 240 


Asn Asn Asp Leu Thr Ser Ser Asn Leu Gln Val Glu Glu Asp Pro Val 
                245                 250                 255     


Asp Phe Gly Asn Ser Trp Lys Val Ser Ser Gln Cys Ala Asp Thr Arg 
            260                 265                 270         


Lys Val Pro Leu Asp Ser Ser Pro Ala Thr Cys His Asn Asn Ile Met 
        275                 280                 285             


Lys Gln Thr Met Val Asp Ser Ser Cys Arg Ile Leu Thr Ser Asp Val 
    290                 295                 300                 


Phe Gln Asp Cys Asn Lys Leu Val Asp Pro Glu Pro Tyr Leu Asp Val 
305                 310                 315                 320 


Cys Ile Tyr Asp Thr Cys Ser Cys Glu Ser Ile Gly Asp Cys Ala Cys 
                325                 330                 335     


Phe Cys Asp Thr Ile Ala Ala Tyr Ala His Val Cys Ala Gln His Gly 
            340                 345                 350         


Lys Val Val Thr Trp Arg Thr Ala Thr Leu Cys Pro Gln Ser Cys Glu 
        355                 360                 365             


Glu Arg Asn Leu Arg Glu Asn Gly Tyr Glu Cys Glu Trp Arg Tyr Asn 
    370                 375                 380                 


Ser Cys Ala Pro Ala Cys Gln Val Thr Cys Gln His Pro Glu Pro Leu 
385                 390                 395                 400 


Ala Cys Pro Val Gln Cys Val Glu Gly Cys His Ala His Cys Pro Pro 
                405                 410                 415     


Gly Lys Ile Leu Asp Glu Leu Leu Gln Thr Cys Val Asp Pro Glu Asp 
            420                 425                 430         


Cys Pro Val Cys Glu Val Ala Gly Arg Arg Phe Ala Ser Gly Lys Lys 
        435                 440                 445             


Val Thr Leu Asn Pro Ser Asp Pro Glu His Cys Gln Ile Cys His Cys 
    450                 455                 460                 


Asp Val Val Asn Leu Thr Cys Glu Ala Cys Gln Glu Pro Gly Gly Leu 
465                 470                 475                 480 


Val Val Pro Pro 
                


<210>  2
<211>  485
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  sequence

<400>  2

Ala Ser Leu Ser Cys Arg Pro Pro Met Val Lys Leu Val Cys Pro Ala 
1               5                   10                  15      


Asp Asn Leu Arg Ala Glu Gly Leu Glu Cys Thr Lys Thr Cys Gln Asn 
            20                  25                  30          


Tyr Asp Leu Glu Cys Met Ser Met Gly Cys Val Ser Gly Cys Leu Cys 
        35                  40                  45              


Pro Pro Gly Met Val Arg His Glu Asn Arg Cys Val Ala Leu Glu Arg 
    50                  55                  60                  


Cys Pro Cys Phe His Gln Gly Lys Glu Tyr Ala Pro Gly Glu Thr Val 
65                  70                  75                  80  


Lys Ile Gly Cys Asn Thr Cys Val Cys Arg Asp Arg Lys Trp Asn Cys 
                85                  90                  95      


Thr Asp His Val Cys Asp Ala Thr Cys Ser Thr Ile Gly Met Ala His 
            100                 105                 110         


Tyr Leu Thr Phe Asp Gly Leu Lys Tyr Leu Phe Pro Gly Glu Cys Gln 
        115                 120                 125             


Tyr Val Leu Val Gln Asp Tyr Cys Gly Ser Asn Pro Gly Thr Phe Arg 
    130                 135                 140                 


Ile Leu Val Gly Asn Lys Gly Cys Ser His Pro Ser Val Lys Cys Lys 
145                 150                 155                 160 


Lys Arg Val Thr Ile Leu Val Glu Gly Gly Glu Ile Glu Leu Phe Asp 
                165                 170                 175     


Gly Glu Val Asn Val Lys Arg Pro Met Lys Asp Glu Thr His Phe Glu 
            180                 185                 190         


Val Val Glu Ser Gly Arg Tyr Ile Ile Leu Leu Leu Gly Lys Ala Leu 
        195                 200                 205             


Ser Val Val Trp Asp Arg His Leu Ser Ile Ser Val Val Leu Lys Gln 
    210                 215                 220                 


Thr Tyr Gln Glu Lys Val Cys Gly Leu Cys Gly Asn Phe Asp Gly Ile 
225                 230                 235                 240 


Gln Asn Asn Asp Leu Thr Ser Ser Asn Leu Gln Val Glu Glu Asp Pro 
                245                 250                 255     


Val Asp Phe Gly Asn Ser Trp Lys Val Ser Ser Gln Cys Ala Asp Thr 
            260                 265                 270         


Arg Lys Val Pro Leu Asp Ser Ser Pro Ala Thr Cys His Asn Asn Ile 
        275                 280                 285             


Met Lys Gln Thr Met Val Asp Ser Ser Cys Arg Ile Leu Thr Ser Asp 
    290                 295                 300                 


Val Phe Gln Asp Cys Asn Lys Leu Val Asp Pro Glu Pro Tyr Leu Asp 
305                 310                 315                 320 


Val Cys Ile Tyr Asp Thr Cys Ser Cys Glu Ser Ile Gly Asp Cys Ala 
                325                 330                 335     


Cys Phe Cys Asp Thr Ile Ala Ala Tyr Ala His Val Cys Ala Gln His 
            340                 345                 350         


Gly Lys Val Val Thr Trp Arg Thr Ala Thr Leu Cys Pro Gln Ser Cys 
        355                 360                 365             


Glu Glu Arg Asn Leu Arg Glu Asn Gly Tyr Glu Cys Glu Trp Arg Tyr 
    370                 375                 380                 


Asn Ser Cys Ala Pro Ala Cys Gln Val Thr Cys Gln His Pro Glu Pro 
385                 390                 395                 400 


Leu Ala Cys Pro Val Gln Cys Val Glu Gly Cys His Ala His Cys Pro 
                405                 410                 415     


Pro Gly Lys Ile Leu Asp Glu Leu Leu Gln Thr Cys Val Asp Pro Glu 
            420                 425                 430         


Asp Cys Pro Val Cys Glu Val Ala Gly Arg Arg Phe Ala Ser Gly Lys 
        435                 440                 445             


Lys Val Thr Leu Asn Pro Ser Asp Pro Glu His Cys Gln Ile Cys His 
    450                 455                 460                 


Cys Asp Val Val Asn Leu Thr Cys Glu Ala Cys Gln Glu Pro Gly Gly 
465                 470                 475                 480 


Leu Val Val Pro Pro 
                485 


<210>  3
<211>  507
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  sequence

<400>  3

Met Ile Pro Ala Arg Phe Ala Gly Val Leu Leu Ala Leu Ala Leu Ile 
1               5                   10                  15      


Leu Pro Gly Thr Leu Cys Ala Ser Leu Ser Cys Arg Pro Pro Met Val 
            20                  25                  30          


Lys Leu Val Cys Pro Ala Asp Asn Leu Arg Ala Glu Gly Leu Glu Cys 
        35                  40                  45              


Thr Lys Thr Cys Gln Asn Tyr Asp Leu Glu Cys Met Ser Met Gly Cys 
    50                  55                  60                  


Val Ser Gly Cys Leu Cys Pro Pro Gly Met Val Arg His Glu Asn Arg 
65                  70                  75                  80  


Cys Val Ala Leu Glu Arg Cys Pro Cys Phe His Gln Gly Lys Glu Tyr 
                85                  90                  95      


Ala Pro Gly Glu Thr Val Lys Ile Gly Cys Asn Thr Cys Val Cys Arg 
            100                 105                 110         


Asp Arg Lys Trp Asn Cys Thr Asp His Val Cys Asp Ala Thr Cys Ser 
        115                 120                 125             


Thr Ile Gly Met Ala His Tyr Leu Thr Phe Asp Gly Leu Lys Tyr Leu 
    130                 135                 140                 


Phe Pro Gly Glu Cys Gln Tyr Val Leu Val Gln Asp Tyr Cys Gly Ser 
145                 150                 155                 160 


Asn Pro Gly Thr Phe Arg Ile Leu Val Gly Asn Lys Gly Cys Ser His 
                165                 170                 175     


Pro Ser Val Lys Cys Lys Lys Arg Val Thr Ile Leu Val Glu Gly Gly 
            180                 185                 190         


Glu Ile Glu Leu Phe Asp Gly Glu Val Asn Val Lys Arg Pro Met Lys 
        195                 200                 205             


Asp Glu Thr His Phe Glu Val Val Glu Ser Gly Arg Tyr Ile Ile Leu 
    210                 215                 220                 


Leu Leu Gly Lys Ala Leu Ser Val Val Trp Asp Arg His Leu Ser Ile 
225                 230                 235                 240 


Ser Val Val Leu Lys Gln Thr Tyr Gln Glu Lys Val Cys Gly Leu Cys 
                245                 250                 255     


Gly Asn Phe Asp Gly Ile Gln Asn Asn Asp Leu Thr Ser Ser Asn Leu 
            260                 265                 270         


Gln Val Glu Glu Asp Pro Val Asp Phe Gly Asn Ser Trp Lys Val Ser 
        275                 280                 285             


Ser Gln Cys Ala Asp Thr Arg Lys Val Pro Leu Asp Ser Ser Pro Ala 
    290                 295                 300                 


Thr Cys His Asn Asn Ile Met Lys Gln Thr Met Val Asp Ser Ser Cys 
305                 310                 315                 320 


Arg Ile Leu Thr Ser Asp Val Phe Gln Asp Cys Asn Lys Leu Val Asp 
                325                 330                 335     


Pro Glu Pro Tyr Leu Asp Val Cys Ile Tyr Asp Thr Cys Ser Cys Glu 
            340                 345                 350         


Ser Ile Gly Asp Cys Ala Cys Phe Cys Asp Thr Ile Ala Ala Tyr Ala 
        355                 360                 365             


His Val Cys Ala Gln His Gly Lys Val Val Thr Trp Arg Thr Ala Thr 
    370                 375                 380                 


Leu Cys Pro Gln Ser Cys Glu Glu Arg Asn Leu Arg Glu Asn Gly Tyr 
385                 390                 395                 400 


Glu Cys Glu Trp Arg Tyr Asn Ser Cys Ala Pro Ala Cys Gln Val Thr 
                405                 410                 415     


Cys Gln His Pro Glu Pro Leu Ala Cys Pro Val Gln Cys Val Glu Gly 
            420                 425                 430         


Cys His Ala His Cys Pro Pro Gly Lys Ile Leu Asp Glu Leu Leu Gln 
        435                 440                 445             


Thr Cys Val Asp Pro Glu Asp Cys Pro Val Cys Glu Val Ala Gly Arg 
    450                 455                 460                 


Arg Phe Ala Ser Gly Lys Lys Val Thr Leu Asn Pro Ser Asp Pro Glu 
465                 470                 475                 480 


His Cys Gln Ile Cys His Cys Asp Val Val Asn Leu Thr Cys Glu Ala 
                485                 490                 495     


Cys Gln Glu Pro Gly Gly Leu Val Val Pro Pro 
            500                 505         


<210>  4
<211>  718
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  sequence

<400>  4

Ser Leu Ser Cys Arg Pro Pro Met Val Lys Leu Val Cys Pro Ala Asp 
1               5                   10                  15      


Asn Leu Arg Ala Glu Gly Leu Glu Cys Thr Lys Thr Cys Gln Asn Tyr 
            20                  25                  30          


Asp Leu Glu Cys Met Ser Met Gly Cys Val Ser Gly Cys Leu Cys Pro 
        35                  40                  45              


Pro Gly Met Val Arg His Glu Asn Arg Cys Val Ala Leu Glu Arg Cys 
    50                  55                  60                  


Pro Cys Phe His Gln Gly Lys Glu Tyr Ala Pro Gly Glu Thr Val Lys 
65                  70                  75                  80  


Ile Gly Cys Asn Thr Cys Val Cys Arg Asp Arg Lys Trp Asn Cys Thr 
                85                  90                  95      


Asp His Val Cys Asp Ala Thr Cys Ser Thr Ile Gly Met Ala His Tyr 
            100                 105                 110         


Leu Thr Phe Asp Gly Leu Lys Tyr Leu Phe Pro Gly Glu Cys Gln Tyr 
        115                 120                 125             


Val Leu Val Gln Asp Tyr Cys Gly Ser Asn Pro Gly Thr Phe Arg Ile 
    130                 135                 140                 


Leu Val Gly Asn Lys Gly Cys Ser His Pro Ser Val Lys Cys Lys Lys 
145                 150                 155                 160 


Arg Val Thr Ile Leu Val Glu Gly Gly Glu Ile Glu Leu Phe Asp Gly 
                165                 170                 175     


Glu Val Asn Val Lys Arg Pro Met Lys Asp Glu Thr His Phe Glu Val 
            180                 185                 190         


Val Glu Ser Gly Arg Tyr Ile Ile Leu Leu Leu Gly Lys Ala Leu Ser 
        195                 200                 205             


Val Val Trp Asp Arg His Leu Ser Ile Ser Val Val Leu Lys Gln Thr 
    210                 215                 220                 


Tyr Gln Glu Lys Val Cys Gly Leu Cys Gly Asn Phe Asp Gly Ile Gln 
225                 230                 235                 240 


Asn Asn Asp Leu Thr Ser Ser Asn Leu Gln Val Glu Glu Asp Pro Val 
                245                 250                 255     


Asp Phe Gly Asn Ser Trp Lys Val Ser Ser Gln Cys Ala Asp Thr Arg 
            260                 265                 270         


Lys Val Pro Leu Asp Ser Ser Pro Ala Thr Cys His Asn Asn Ile Met 
        275                 280                 285             


Lys Gln Thr Met Val Asp Ser Ser Cys Arg Ile Leu Thr Ser Asp Val 
    290                 295                 300                 


Phe Gln Asp Cys Asn Lys Leu Val Asp Pro Glu Pro Tyr Leu Asp Val 
305                 310                 315                 320 


Cys Ile Tyr Asp Thr Cys Ser Cys Glu Ser Ile Gly Asp Cys Ala Cys 
                325                 330                 335     


Phe Cys Asp Thr Ile Ala Ala Tyr Ala His Val Cys Ala Gln His Gly 
            340                 345                 350         


Lys Val Val Thr Trp Arg Thr Ala Thr Leu Cys Pro Gln Ser Cys Glu 
        355                 360                 365             


Glu Arg Asn Leu Arg Glu Asn Gly Tyr Glu Cys Glu Trp Arg Tyr Asn 
    370                 375                 380                 


Ser Cys Ala Pro Ala Cys Gln Val Thr Cys Gln His Pro Glu Pro Leu 
385                 390                 395                 400 


Ala Cys Pro Val Gln Cys Val Glu Gly Cys His Ala His Cys Pro Pro 
                405                 410                 415     


Gly Lys Ile Leu Asp Glu Leu Leu Gln Thr Cys Val Asp Pro Glu Asp 
            420                 425                 430         


Cys Pro Val Cys Glu Val Ala Gly Arg Arg Phe Ala Ser Gly Lys Lys 
        435                 440                 445             


Val Thr Leu Asn Pro Ser Asp Pro Glu His Cys Gln Ile Cys His Cys 
    450                 455                 460                 


Asp Val Val Asn Leu Thr Cys Glu Ala Cys Gln Glu Pro Gly Gly Leu 
465                 470                 475                 480 


Val Val Pro Pro Thr Asp Ala Pro Val Ser Pro Thr Thr Leu Tyr Val 
                485                 490                 495     


Glu Asp Ile Ser Glu Pro Pro Leu His Asp Phe Tyr Cys Ser Arg Leu 
            500                 505                 510         


Leu Asp Leu Val Phe Leu Leu Asp Gly Ser Ser Arg Leu Ser Glu Ala 
        515                 520                 525             


Glu Phe Glu Val Leu Lys Ala Phe Val Val Asp Met Met Glu Arg Leu 
    530                 535                 540                 


Arg Ile Ser Gln Lys Trp Val Arg Val Ala Val Val Glu Tyr His Asp 
545                 550                 555                 560 


Gly Ser His Ala Tyr Ile Gly Leu Lys Asp Arg Lys Arg Pro Ser Glu 
                565                 570                 575     


Leu Arg Arg Ile Ala Ser Gln Val Lys Tyr Ala Gly Ser Gln Val Ala 
            580                 585                 590         


Ser Thr Ser Glu Val Leu Lys Tyr Thr Leu Phe Gln Ile Phe Ser Lys 
        595                 600                 605             


Ile Asp Arg Pro Glu Ala Ser Arg Ile Ala Leu Leu Leu Met Ala Ser 
    610                 615                 620                 


Gln Glu Pro Gln Arg Met Ser Arg Asn Phe Val Arg Tyr Val Gln Gly 
625                 630                 635                 640 


Leu Lys Lys Lys Lys Val Ile Val Ile Pro Val Gly Ile Gly Pro His 
                645                 650                 655     


Ala Asn Leu Lys Gln Ile Arg Leu Ile Glu Lys Gln Ala Pro Glu Asn 
            660                 665                 670         


Lys Ala Phe Val Leu Ser Ser Val Asp Glu Leu Glu Gln Gln Arg Asp 
        675                 680                 685             


Glu Ile Val Ser Tyr Leu Cys Asp Leu Ala Pro Glu Ala Pro Pro Pro 
    690                 695                 700                 


Thr Leu Pro Pro His Met Ala Gln Val Thr Val Gly Pro Gly 
705                 710                 715             


<210>  5
<211>  719
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  sequence

<400>  5

Ala Ser Leu Ser Cys Arg Pro Pro Met Val Lys Leu Val Cys Pro Ala 
1               5                   10                  15      


Asp Asn Leu Arg Ala Glu Gly Leu Glu Cys Thr Lys Thr Cys Gln Asn 
            20                  25                  30          


Tyr Asp Leu Glu Cys Met Ser Met Gly Cys Val Ser Gly Cys Leu Cys 
        35                  40                  45              


Pro Pro Gly Met Val Arg His Glu Asn Arg Cys Val Ala Leu Glu Arg 
    50                  55                  60                  


Cys Pro Cys Phe His Gln Gly Lys Glu Tyr Ala Pro Gly Glu Thr Val 
65                  70                  75                  80  


Lys Ile Gly Cys Asn Thr Cys Val Cys Arg Asp Arg Lys Trp Asn Cys 
                85                  90                  95      


Thr Asp His Val Cys Asp Ala Thr Cys Ser Thr Ile Gly Met Ala His 
            100                 105                 110         


Tyr Leu Thr Phe Asp Gly Leu Lys Tyr Leu Phe Pro Gly Glu Cys Gln 
        115                 120                 125             


Tyr Val Leu Val Gln Asp Tyr Cys Gly Ser Asn Pro Gly Thr Phe Arg 
    130                 135                 140                 


Ile Leu Val Gly Asn Lys Gly Cys Ser His Pro Ser Val Lys Cys Lys 
145                 150                 155                 160 


Lys Arg Val Thr Ile Leu Val Glu Gly Gly Glu Ile Glu Leu Phe Asp 
                165                 170                 175     


Gly Glu Val Asn Val Lys Arg Pro Met Lys Asp Glu Thr His Phe Glu 
            180                 185                 190         


Val Val Glu Ser Gly Arg Tyr Ile Ile Leu Leu Leu Gly Lys Ala Leu 
        195                 200                 205             


Ser Val Val Trp Asp Arg His Leu Ser Ile Ser Val Val Leu Lys Gln 
    210                 215                 220                 


Thr Tyr Gln Glu Lys Val Cys Gly Leu Cys Gly Asn Phe Asp Gly Ile 
225                 230                 235                 240 


Gln Asn Asn Asp Leu Thr Ser Ser Asn Leu Gln Val Glu Glu Asp Pro 
                245                 250                 255     


Val Asp Phe Gly Asn Ser Trp Lys Val Ser Ser Gln Cys Ala Asp Thr 
            260                 265                 270         


Arg Lys Val Pro Leu Asp Ser Ser Pro Ala Thr Cys His Asn Asn Ile 
        275                 280                 285             


Met Lys Gln Thr Met Val Asp Ser Ser Cys Arg Ile Leu Thr Ser Asp 
    290                 295                 300                 


Val Phe Gln Asp Cys Asn Lys Leu Val Asp Pro Glu Pro Tyr Leu Asp 
305                 310                 315                 320 


Val Cys Ile Tyr Asp Thr Cys Ser Cys Glu Ser Ile Gly Asp Cys Ala 
                325                 330                 335     


Cys Phe Cys Asp Thr Ile Ala Ala Tyr Ala His Val Cys Ala Gln His 
            340                 345                 350         


Gly Lys Val Val Thr Trp Arg Thr Ala Thr Leu Cys Pro Gln Ser Cys 
        355                 360                 365             


Glu Glu Arg Asn Leu Arg Glu Asn Gly Tyr Glu Cys Glu Trp Arg Tyr 
    370                 375                 380                 


Asn Ser Cys Ala Pro Ala Cys Gln Val Thr Cys Gln His Pro Glu Pro 
385                 390                 395                 400 


Leu Ala Cys Pro Val Gln Cys Val Glu Gly Cys His Ala His Cys Pro 
                405                 410                 415     


Pro Gly Lys Ile Leu Asp Glu Leu Leu Gln Thr Cys Val Asp Pro Glu 
            420                 425                 430         


Asp Cys Pro Val Cys Glu Val Ala Gly Arg Arg Phe Ala Ser Gly Lys 
        435                 440                 445             


Lys Val Thr Leu Asn Pro Ser Asp Pro Glu His Cys Gln Ile Cys His 
    450                 455                 460                 


Cys Asp Val Val Asn Leu Thr Cys Glu Ala Cys Gln Glu Pro Gly Gly 
465                 470                 475                 480 


Leu Val Val Pro Pro Thr Asp Ala Pro Val Ser Pro Thr Thr Leu Tyr 
                485                 490                 495     


Val Glu Asp Ile Ser Glu Pro Pro Leu His Asp Phe Tyr Cys Ser Arg 
            500                 505                 510         


Leu Leu Asp Leu Val Phe Leu Leu Asp Gly Ser Ser Arg Leu Ser Glu 
        515                 520                 525             


Ala Glu Phe Glu Val Leu Lys Ala Phe Val Val Asp Met Met Glu Arg 
    530                 535                 540                 


Leu Arg Ile Ser Gln Lys Trp Val Arg Val Ala Val Val Glu Tyr His 
545                 550                 555                 560 


Asp Gly Ser His Ala Tyr Ile Gly Leu Lys Asp Arg Lys Arg Pro Ser 
                565                 570                 575     


Glu Leu Arg Arg Ile Ala Ser Gln Val Lys Tyr Ala Gly Ser Gln Val 
            580                 585                 590         


Ala Ser Thr Ser Glu Val Leu Lys Tyr Thr Leu Phe Gln Ile Phe Ser 
        595                 600                 605             


Lys Ile Asp Arg Pro Glu Ala Ser Arg Ile Ala Leu Leu Leu Met Ala 
    610                 615                 620                 


Ser Gln Glu Pro Gln Arg Met Ser Arg Asn Phe Val Arg Tyr Val Gln 
625                 630                 635                 640 


Gly Leu Lys Lys Lys Lys Val Ile Val Ile Pro Val Gly Ile Gly Pro 
                645                 650                 655     


His Ala Asn Leu Lys Gln Ile Arg Leu Ile Glu Lys Gln Ala Pro Glu 
            660                 665                 670         


Asn Lys Ala Phe Val Leu Ser Ser Val Asp Glu Leu Glu Gln Gln Arg 
        675                 680                 685             


Asp Glu Ile Val Ser Tyr Leu Cys Asp Leu Ala Pro Glu Ala Pro Pro 
    690                 695                 700                 


Pro Thr Leu Pro Pro His Met Ala Gln Val Thr Val Gly Pro Gly 
705                 710                 715                 


<210>  6
<211>  741
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  sequence

<400>  6

Met Ile Pro Ala Arg Phe Ala Gly Val Leu Leu Ala Leu Ala Leu Ile 
1               5                   10                  15      


Leu Pro Gly Thr Leu Cys Ala Ser Leu Ser Cys Arg Pro Pro Met Val 
            20                  25                  30          


Lys Leu Val Cys Pro Ala Asp Asn Leu Arg Ala Glu Gly Leu Glu Cys 
        35                  40                  45              


Thr Lys Thr Cys Gln Asn Tyr Asp Leu Glu Cys Met Ser Met Gly Cys 
    50                  55                  60                  


Val Ser Gly Cys Leu Cys Pro Pro Gly Met Val Arg His Glu Asn Arg 
65                  70                  75                  80  


Cys Val Ala Leu Glu Arg Cys Pro Cys Phe His Gln Gly Lys Glu Tyr 
                85                  90                  95      


Ala Pro Gly Glu Thr Val Lys Ile Gly Cys Asn Thr Cys Val Cys Arg 
            100                 105                 110         


Asp Arg Lys Trp Asn Cys Thr Asp His Val Cys Asp Ala Thr Cys Ser 
        115                 120                 125             


Thr Ile Gly Met Ala His Tyr Leu Thr Phe Asp Gly Leu Lys Tyr Leu 
    130                 135                 140                 


Phe Pro Gly Glu Cys Gln Tyr Val Leu Val Gln Asp Tyr Cys Gly Ser 
145                 150                 155                 160 


Asn Pro Gly Thr Phe Arg Ile Leu Val Gly Asn Lys Gly Cys Ser His 
                165                 170                 175     


Pro Ser Val Lys Cys Lys Lys Arg Val Thr Ile Leu Val Glu Gly Gly 
            180                 185                 190         


Glu Ile Glu Leu Phe Asp Gly Glu Val Asn Val Lys Arg Pro Met Lys 
        195                 200                 205             


Asp Glu Thr His Phe Glu Val Val Glu Ser Gly Arg Tyr Ile Ile Leu 
    210                 215                 220                 


Leu Leu Gly Lys Ala Leu Ser Val Val Trp Asp Arg His Leu Ser Ile 
225                 230                 235                 240 


Ser Val Val Leu Lys Gln Thr Tyr Gln Glu Lys Val Cys Gly Leu Cys 
                245                 250                 255     


Gly Asn Phe Asp Gly Ile Gln Asn Asn Asp Leu Thr Ser Ser Asn Leu 
            260                 265                 270         


Gln Val Glu Glu Asp Pro Val Asp Phe Gly Asn Ser Trp Lys Val Ser 
        275                 280                 285             


Ser Gln Cys Ala Asp Thr Arg Lys Val Pro Leu Asp Ser Ser Pro Ala 
    290                 295                 300                 


Thr Cys His Asn Asn Ile Met Lys Gln Thr Met Val Asp Ser Ser Cys 
305                 310                 315                 320 


Arg Ile Leu Thr Ser Asp Val Phe Gln Asp Cys Asn Lys Leu Val Asp 
                325                 330                 335     


Pro Glu Pro Tyr Leu Asp Val Cys Ile Tyr Asp Thr Cys Ser Cys Glu 
            340                 345                 350         


Ser Ile Gly Asp Cys Ala Cys Phe Cys Asp Thr Ile Ala Ala Tyr Ala 
        355                 360                 365             


His Val Cys Ala Gln His Gly Lys Val Val Thr Trp Arg Thr Ala Thr 
    370                 375                 380                 


Leu Cys Pro Gln Ser Cys Glu Glu Arg Asn Leu Arg Glu Asn Gly Tyr 
385                 390                 395                 400 


Glu Cys Glu Trp Arg Tyr Asn Ser Cys Ala Pro Ala Cys Gln Val Thr 
                405                 410                 415     


Cys Gln His Pro Glu Pro Leu Ala Cys Pro Val Gln Cys Val Glu Gly 
            420                 425                 430         


Cys His Ala His Cys Pro Pro Gly Lys Ile Leu Asp Glu Leu Leu Gln 
        435                 440                 445             


Thr Cys Val Asp Pro Glu Asp Cys Pro Val Cys Glu Val Ala Gly Arg 
    450                 455                 460                 


Arg Phe Ala Ser Gly Lys Lys Val Thr Leu Asn Pro Ser Asp Pro Glu 
465                 470                 475                 480 


His Cys Gln Ile Cys His Cys Asp Val Val Asn Leu Thr Cys Glu Ala 
                485                 490                 495     


Cys Gln Glu Pro Gly Gly Leu Val Val Pro Pro Thr Asp Ala Pro Val 
            500                 505                 510         


Ser Pro Thr Thr Leu Tyr Val Glu Asp Ile Ser Glu Pro Pro Leu His 
        515                 520                 525             


Asp Phe Tyr Cys Ser Arg Leu Leu Asp Leu Val Phe Leu Leu Asp Gly 
    530                 535                 540                 


Ser Ser Arg Leu Ser Glu Ala Glu Phe Glu Val Leu Lys Ala Phe Val 
545                 550                 555                 560 


Val Asp Met Met Glu Arg Leu Arg Ile Ser Gln Lys Trp Val Arg Val 
                565                 570                 575     


Ala Val Val Glu Tyr His Asp Gly Ser His Ala Tyr Ile Gly Leu Lys 
            580                 585                 590         


Asp Arg Lys Arg Pro Ser Glu Leu Arg Arg Ile Ala Ser Gln Val Lys 
        595                 600                 605             


Tyr Ala Gly Ser Gln Val Ala Ser Thr Ser Glu Val Leu Lys Tyr Thr 
    610                 615                 620                 


Leu Phe Gln Ile Phe Ser Lys Ile Asp Arg Pro Glu Ala Ser Arg Ile 
625                 630                 635                 640 


Ala Leu Leu Leu Met Ala Ser Gln Glu Pro Gln Arg Met Ser Arg Asn 
                645                 650                 655     


Phe Val Arg Tyr Val Gln Gly Leu Lys Lys Lys Lys Val Ile Val Ile 
            660                 665                 670         


Pro Val Gly Ile Gly Pro His Ala Asn Leu Lys Gln Ile Arg Leu Ile 
        675                 680                 685             


Glu Lys Gln Ala Pro Glu Asn Lys Ala Phe Val Leu Ser Ser Val Asp 
    690                 695                 700                 


Glu Leu Glu Gln Gln Arg Asp Glu Ile Val Ser Tyr Leu Cys Asp Leu 
705                 710                 715                 720 


Ala Pro Glu Ala Pro Pro Pro Thr Leu Pro Pro His Met Ala Gln Val 
                725                 730                 735     


Thr Val Gly Pro Gly 
            740     


<210>  7
<211>  1116
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  sequence

<400>  7

Ser Leu Ser Cys Arg Pro Pro Met Val Lys Leu Val Cys Pro Ala Asp 
1               5                   10                  15      


Asn Leu Arg Ala Glu Gly Leu Glu Cys Thr Lys Thr Cys Gln Asn Tyr 
            20                  25                  30          


Asp Leu Glu Cys Met Ser Met Gly Cys Val Ser Gly Cys Leu Cys Pro 
        35                  40                  45              


Pro Gly Met Val Arg His Glu Asn Arg Cys Val Ala Leu Glu Arg Cys 
    50                  55                  60                  


Pro Cys Phe His Gln Gly Lys Glu Tyr Ala Pro Gly Glu Thr Val Lys 
65                  70                  75                  80  


Ile Gly Cys Asn Thr Cys Val Cys Arg Asp Arg Lys Trp Asn Cys Thr 
                85                  90                  95      


Asp His Val Cys Asp Ala Thr Cys Ser Thr Ile Gly Met Ala His Tyr 
            100                 105                 110         


Leu Thr Phe Asp Gly Leu Lys Tyr Leu Phe Pro Gly Glu Cys Gln Tyr 
        115                 120                 125             


Val Leu Val Gln Asp Tyr Cys Gly Ser Asn Pro Gly Thr Phe Arg Ile 
    130                 135                 140                 


Leu Val Gly Asn Lys Gly Cys Ser His Pro Ser Val Lys Cys Lys Lys 
145                 150                 155                 160 


Arg Val Thr Ile Leu Val Glu Gly Gly Glu Ile Glu Leu Phe Asp Gly 
                165                 170                 175     


Glu Val Asn Val Lys Arg Pro Met Lys Asp Glu Thr His Phe Glu Val 
            180                 185                 190         


Val Glu Ser Gly Arg Tyr Ile Ile Leu Leu Leu Gly Lys Ala Leu Ser 
        195                 200                 205             


Val Val Trp Asp Arg His Leu Ser Ile Ser Val Val Leu Lys Gln Thr 
    210                 215                 220                 


Tyr Gln Glu Lys Val Cys Gly Leu Cys Gly Asn Phe Asp Gly Ile Gln 
225                 230                 235                 240 


Asn Asn Asp Leu Thr Ser Ser Asn Leu Gln Val Glu Glu Asp Pro Val 
                245                 250                 255     


Asp Phe Gly Asn Ser Trp Lys Val Ser Ser Gln Cys Ala Asp Thr Arg 
            260                 265                 270         


Lys Val Pro Leu Asp Ser Ser Pro Ala Thr Cys His Asn Asn Ile Met 
        275                 280                 285             


Lys Gln Thr Met Val Asp Ser Ser Cys Arg Ile Leu Thr Ser Asp Val 
    290                 295                 300                 


Phe Gln Asp Cys Asn Lys Leu Val Asp Pro Glu Pro Tyr Leu Asp Val 
305                 310                 315                 320 


Cys Ile Tyr Asp Thr Cys Ser Cys Glu Ser Ile Gly Asp Cys Ala Cys 
                325                 330                 335     


Phe Cys Asp Thr Ile Ala Ala Tyr Ala His Val Cys Ala Gln His Gly 
            340                 345                 350         


Lys Val Val Thr Trp Arg Thr Ala Thr Leu Cys Pro Gln Ser Cys Glu 
        355                 360                 365             


Glu Arg Asn Leu Arg Glu Asn Gly Tyr Glu Cys Glu Trp Arg Tyr Asn 
    370                 375                 380                 


Ser Cys Ala Pro Ala Cys Gln Val Thr Cys Gln His Pro Glu Pro Leu 
385                 390                 395                 400 


Ala Cys Pro Val Gln Cys Val Glu Gly Cys His Ala His Cys Pro Pro 
                405                 410                 415     


Gly Lys Ile Leu Asp Glu Leu Leu Gln Thr Cys Val Asp Pro Glu Asp 
            420                 425                 430         


Cys Pro Val Cys Glu Val Ala Gly Arg Arg Phe Ala Ser Gly Lys Lys 
        435                 440                 445             


Val Thr Leu Asn Pro Ser Asp Pro Glu His Cys Gln Ile Cys His Cys 
    450                 455                 460                 


Asp Val Val Asn Leu Thr Cys Glu Ala Cys Gln Glu Pro Gly Gly Leu 
465                 470                 475                 480 


Val Val Pro Pro Thr Asp Ala Pro Val Ser Pro Thr Thr Leu Tyr Val 
                485                 490                 495     


Glu Asp Ile Ser Glu Pro Pro Leu His Asp Phe Tyr Cys Ser Arg Leu 
            500                 505                 510         


Leu Asp Leu Val Phe Leu Leu Asp Gly Ser Ser Arg Leu Ser Glu Ala 
        515                 520                 525             


Glu Phe Glu Val Leu Lys Ala Phe Val Val Asp Met Met Glu Arg Leu 
    530                 535                 540                 


Arg Ile Ser Gln Lys Trp Val Arg Val Ala Val Val Glu Tyr His Asp 
545                 550                 555                 560 


Gly Ser His Ala Tyr Ile Gly Leu Lys Asp Arg Lys Arg Pro Ser Glu 
                565                 570                 575     


Leu Arg Arg Ile Ala Ser Gln Val Lys Tyr Ala Gly Ser Gln Val Ala 
            580                 585                 590         


Ser Thr Ser Glu Val Leu Lys Tyr Thr Leu Phe Gln Ile Phe Ser Lys 
        595                 600                 605             


Ile Asp Arg Pro Glu Ala Ser Arg Ile Ala Leu Leu Leu Met Ala Ser 
    610                 615                 620                 


Gln Glu Pro Gln Arg Met Ser Arg Asn Phe Val Arg Tyr Val Gln Gly 
625                 630                 635                 640 


Leu Lys Lys Lys Lys Val Ile Val Ile Pro Val Gly Ile Gly Pro His 
                645                 650                 655     


Ala Asn Leu Lys Gln Ile Arg Leu Ile Glu Lys Gln Ala Pro Glu Asn 
            660                 665                 670         


Lys Ala Phe Val Leu Ser Ser Val Asp Glu Leu Glu Gln Gln Arg Asp 
        675                 680                 685             


Glu Ile Val Ser Tyr Leu Cys Asp Leu Ala Pro Glu Ala Pro Pro Pro 
    690                 695                 700                 


Thr Leu Pro Pro His Met Ala Gln Val Thr Val Gly Pro Gly Leu Leu 
705                 710                 715                 720 


Gly Val Ser Thr Leu Gly Pro Lys Arg Asn Ser Met Val Leu Asp Val 
                725                 730                 735     


Ala Phe Val Leu Glu Gly Ser Asp Lys Ile Gly Glu Ala Asp Phe Asn 
            740                 745                 750         


Arg Ser Lys Glu Phe Met Glu Glu Val Ile Gln Arg Met Asp Val Gly 
        755                 760                 765             


Gln Asp Ser Ile His Val Thr Val Leu Gln Tyr Ser Tyr Met Val Thr 
    770                 775                 780                 


Val Glu Tyr Pro Phe Ser Glu Ala Gln Ser Lys Gly Asp Ile Leu Gln 
785                 790                 795                 800 


Arg Val Arg Glu Ile Arg Tyr Gln Gly Gly Asn Arg Thr Asn Thr Gly 
                805                 810                 815     


Leu Ala Leu Arg Tyr Leu Ser Asp His Ser Phe Leu Val Ser Gln Gly 
            820                 825                 830         


Asp Arg Glu Gln Ala Pro Asn Leu Val Tyr Met Val Thr Gly Asn Pro 
        835                 840                 845             


Ala Ser Asp Glu Ile Lys Arg Leu Pro Gly Asp Ile Gln Val Val Pro 
    850                 855                 860                 


Ile Gly Val Gly Pro Asn Ala Asn Val Gln Glu Leu Glu Arg Ile Gly 
865                 870                 875                 880 


Trp Pro Asn Ala Pro Ile Leu Ile Gln Asp Phe Glu Thr Leu Pro Arg 
                885                 890                 895     


Glu Ala Pro Asp Leu Val Leu Gln Arg Cys Cys Ser Gly Glu Gly Leu 
            900                 905                 910         


Gln Ile Pro Thr Leu Ser Pro Ala Pro Asp Cys Ser Gln Pro Leu Asp 
        915                 920                 925             


Val Ile Leu Leu Leu Asp Gly Ser Ser Ser Phe Pro Ala Ser Tyr Phe 
    930                 935                 940                 


Asp Glu Met Lys Ser Phe Ala Lys Ala Phe Ile Ser Lys Ala Asn Ile 
945                 950                 955                 960 


Gly Pro Arg Leu Thr Gln Val Ser Val Leu Gln Tyr Gly Ser Ile Thr 
                965                 970                 975     


Thr Ile Asp Val Pro Trp Asn Val Val Pro Glu Lys Ala His Leu Leu 
            980                 985                 990         


Ser Leu Val Asp Val Met Gln Arg  Glu Gly Gly Pro Ser  Gln Ile Gly 
        995                 1000                 1005             


Asp Ala  Leu Gly Phe Ala Val  Arg Tyr Leu Thr Ser  Glu Met His 
    1010                 1015                 1020             


Gly Ala  Arg Pro Gly Ala Ser  Lys Ala Val Val Ile  Leu Val Thr 
    1025                 1030                 1035             


Asp Val  Ser Val Asp Ser Val  Asp Ala Ala Ala Asp  Ala Ala Arg 
    1040                 1045                 1050             


Ser Asn  Arg Val Thr Val Phe  Pro Ile Gly Ile Gly  Asp Arg Tyr 
    1055                 1060                 1065             


Asp Ala  Ala Gln Leu Arg Ile  Leu Ala Gly Pro Ala  Gly Asp Ser 
    1070                 1075                 1080             


Asn Val  Val Lys Leu Gln Arg  Ile Glu Asp Leu Pro  Thr Met Val 
    1085                 1090                 1095             


Thr Leu  Gly Asn Ser Phe Leu  His Lys Leu Cys Ser  Gly Phe Val 
    1100                 1105                 1110             


Arg Ile  Cys 
    1115     


<210>  8
<211>  1117
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  sequence

<400>  8

Ala Ser Leu Ser Cys Arg Pro Pro Met Val Lys Leu Val Cys Pro Ala 
1               5                   10                  15      


Asp Asn Leu Arg Ala Glu Gly Leu Glu Cys Thr Lys Thr Cys Gln Asn 
            20                  25                  30          


Tyr Asp Leu Glu Cys Met Ser Met Gly Cys Val Ser Gly Cys Leu Cys 
        35                  40                  45              


Pro Pro Gly Met Val Arg His Glu Asn Arg Cys Val Ala Leu Glu Arg 
    50                  55                  60                  


Cys Pro Cys Phe His Gln Gly Lys Glu Tyr Ala Pro Gly Glu Thr Val 
65                  70                  75                  80  


Lys Ile Gly Cys Asn Thr Cys Val Cys Arg Asp Arg Lys Trp Asn Cys 
                85                  90                  95      


Thr Asp His Val Cys Asp Ala Thr Cys Ser Thr Ile Gly Met Ala His 
            100                 105                 110         


Tyr Leu Thr Phe Asp Gly Leu Lys Tyr Leu Phe Pro Gly Glu Cys Gln 
        115                 120                 125             


Tyr Val Leu Val Gln Asp Tyr Cys Gly Ser Asn Pro Gly Thr Phe Arg 
    130                 135                 140                 


Ile Leu Val Gly Asn Lys Gly Cys Ser His Pro Ser Val Lys Cys Lys 
145                 150                 155                 160 


Lys Arg Val Thr Ile Leu Val Glu Gly Gly Glu Ile Glu Leu Phe Asp 
                165                 170                 175     


Gly Glu Val Asn Val Lys Arg Pro Met Lys Asp Glu Thr His Phe Glu 
            180                 185                 190         


Val Val Glu Ser Gly Arg Tyr Ile Ile Leu Leu Leu Gly Lys Ala Leu 
        195                 200                 205             


Ser Val Val Trp Asp Arg His Leu Ser Ile Ser Val Val Leu Lys Gln 
    210                 215                 220                 


Thr Tyr Gln Glu Lys Val Cys Gly Leu Cys Gly Asn Phe Asp Gly Ile 
225                 230                 235                 240 


Gln Asn Asn Asp Leu Thr Ser Ser Asn Leu Gln Val Glu Glu Asp Pro 
                245                 250                 255     


Val Asp Phe Gly Asn Ser Trp Lys Val Ser Ser Gln Cys Ala Asp Thr 
            260                 265                 270         


Arg Lys Val Pro Leu Asp Ser Ser Pro Ala Thr Cys His Asn Asn Ile 
        275                 280                 285             


Met Lys Gln Thr Met Val Asp Ser Ser Cys Arg Ile Leu Thr Ser Asp 
    290                 295                 300                 


Val Phe Gln Asp Cys Asn Lys Leu Val Asp Pro Glu Pro Tyr Leu Asp 
305                 310                 315                 320 


Val Cys Ile Tyr Asp Thr Cys Ser Cys Glu Ser Ile Gly Asp Cys Ala 
                325                 330                 335     


Cys Phe Cys Asp Thr Ile Ala Ala Tyr Ala His Val Cys Ala Gln His 
            340                 345                 350         


Gly Lys Val Val Thr Trp Arg Thr Ala Thr Leu Cys Pro Gln Ser Cys 
        355                 360                 365             


Glu Glu Arg Asn Leu Arg Glu Asn Gly Tyr Glu Cys Glu Trp Arg Tyr 
    370                 375                 380                 


Asn Ser Cys Ala Pro Ala Cys Gln Val Thr Cys Gln His Pro Glu Pro 
385                 390                 395                 400 


Leu Ala Cys Pro Val Gln Cys Val Glu Gly Cys His Ala His Cys Pro 
                405                 410                 415     


Pro Gly Lys Ile Leu Asp Glu Leu Leu Gln Thr Cys Val Asp Pro Glu 
            420                 425                 430         


Asp Cys Pro Val Cys Glu Val Ala Gly Arg Arg Phe Ala Ser Gly Lys 
        435                 440                 445             


Lys Val Thr Leu Asn Pro Ser Asp Pro Glu His Cys Gln Ile Cys His 
    450                 455                 460                 


Cys Asp Val Val Asn Leu Thr Cys Glu Ala Cys Gln Glu Pro Gly Gly 
465                 470                 475                 480 


Leu Val Val Pro Pro Thr Asp Ala Pro Val Ser Pro Thr Thr Leu Tyr 
                485                 490                 495     


Val Glu Asp Ile Ser Glu Pro Pro Leu His Asp Phe Tyr Cys Ser Arg 
            500                 505                 510         


Leu Leu Asp Leu Val Phe Leu Leu Asp Gly Ser Ser Arg Leu Ser Glu 
        515                 520                 525             


Ala Glu Phe Glu Val Leu Lys Ala Phe Val Val Asp Met Met Glu Arg 
    530                 535                 540                 


Leu Arg Ile Ser Gln Lys Trp Val Arg Val Ala Val Val Glu Tyr His 
545                 550                 555                 560 


Asp Gly Ser His Ala Tyr Ile Gly Leu Lys Asp Arg Lys Arg Pro Ser 
                565                 570                 575     


Glu Leu Arg Arg Ile Ala Ser Gln Val Lys Tyr Ala Gly Ser Gln Val 
            580                 585                 590         


Ala Ser Thr Ser Glu Val Leu Lys Tyr Thr Leu Phe Gln Ile Phe Ser 
        595                 600                 605             


Lys Ile Asp Arg Pro Glu Ala Ser Arg Ile Ala Leu Leu Leu Met Ala 
    610                 615                 620                 


Ser Gln Glu Pro Gln Arg Met Ser Arg Asn Phe Val Arg Tyr Val Gln 
625                 630                 635                 640 


Gly Leu Lys Lys Lys Lys Val Ile Val Ile Pro Val Gly Ile Gly Pro 
                645                 650                 655     


His Ala Asn Leu Lys Gln Ile Arg Leu Ile Glu Lys Gln Ala Pro Glu 
            660                 665                 670         


Asn Lys Ala Phe Val Leu Ser Ser Val Asp Glu Leu Glu Gln Gln Arg 
        675                 680                 685             


Asp Glu Ile Val Ser Tyr Leu Cys Asp Leu Ala Pro Glu Ala Pro Pro 
    690                 695                 700                 


Pro Thr Leu Pro Pro His Met Ala Gln Val Thr Val Gly Pro Gly Leu 
705                 710                 715                 720 


Leu Gly Val Ser Thr Leu Gly Pro Lys Arg Asn Ser Met Val Leu Asp 
                725                 730                 735     


Val Ala Phe Val Leu Glu Gly Ser Asp Lys Ile Gly Glu Ala Asp Phe 
            740                 745                 750         


Asn Arg Ser Lys Glu Phe Met Glu Glu Val Ile Gln Arg Met Asp Val 
        755                 760                 765             


Gly Gln Asp Ser Ile His Val Thr Val Leu Gln Tyr Ser Tyr Met Val 
    770                 775                 780                 


Thr Val Glu Tyr Pro Phe Ser Glu Ala Gln Ser Lys Gly Asp Ile Leu 
785                 790                 795                 800 


Gln Arg Val Arg Glu Ile Arg Tyr Gln Gly Gly Asn Arg Thr Asn Thr 
                805                 810                 815     


Gly Leu Ala Leu Arg Tyr Leu Ser Asp His Ser Phe Leu Val Ser Gln 
            820                 825                 830         


Gly Asp Arg Glu Gln Ala Pro Asn Leu Val Tyr Met Val Thr Gly Asn 
        835                 840                 845             


Pro Ala Ser Asp Glu Ile Lys Arg Leu Pro Gly Asp Ile Gln Val Val 
    850                 855                 860                 


Pro Ile Gly Val Gly Pro Asn Ala Asn Val Gln Glu Leu Glu Arg Ile 
865                 870                 875                 880 


Gly Trp Pro Asn Ala Pro Ile Leu Ile Gln Asp Phe Glu Thr Leu Pro 
                885                 890                 895     


Arg Glu Ala Pro Asp Leu Val Leu Gln Arg Cys Cys Ser Gly Glu Gly 
            900                 905                 910         


Leu Gln Ile Pro Thr Leu Ser Pro Ala Pro Asp Cys Ser Gln Pro Leu 
        915                 920                 925             


Asp Val Ile Leu Leu Leu Asp Gly Ser Ser Ser Phe Pro Ala Ser Tyr 
    930                 935                 940                 


Phe Asp Glu Met Lys Ser Phe Ala Lys Ala Phe Ile Ser Lys Ala Asn 
945                 950                 955                 960 


Ile Gly Pro Arg Leu Thr Gln Val Ser Val Leu Gln Tyr Gly Ser Ile 
                965                 970                 975     


Thr Thr Ile Asp Val Pro Trp Asn Val Val Pro Glu Lys Ala His Leu 
            980                 985                 990         


Leu Ser Leu Val Asp Val Met Gln  Arg Glu Gly Gly Pro  Ser Gln Ile 
        995                 1000                 1005             


Gly Asp  Ala Leu Gly Phe Ala  Val Arg Tyr Leu Thr  Ser Glu Met 
    1010                 1015                 1020             


His Gly  Ala Arg Pro Gly Ala  Ser Lys Ala Val Val  Ile Leu Val 
    1025                 1030                 1035             


Thr Asp  Val Ser Val Asp Ser  Val Asp Ala Ala Ala  Asp Ala Ala 
    1040                 1045                 1050             


Arg Ser  Asn Arg Val Thr Val  Phe Pro Ile Gly Ile  Gly Asp Arg 
    1055                 1060                 1065             


Tyr Asp  Ala Ala Gln Leu Arg  Ile Leu Ala Gly Pro  Ala Gly Asp 
    1070                 1075                 1080             


Ser Asn  Val Val Lys Leu Gln  Arg Ile Glu Asp Leu  Pro Thr Met 
    1085                 1090                 1095             


Val Thr  Leu Gly Asn Ser Phe  Leu His Lys Leu Cys  Ser Gly Phe 
    1100                 1105                 1110             


Val Arg  Ile Cys 
    1115         


<210>  9
<211>  1139
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  sequence

<400>  9

Met Ile Pro Ala Arg Phe Ala Gly Val Leu Leu Ala Leu Ala Leu Ile 
1               5                   10                  15      


Leu Pro Gly Thr Leu Cys Ala Ser Leu Ser Cys Arg Pro Pro Met Val 
            20                  25                  30          


Lys Leu Val Cys Pro Ala Asp Asn Leu Arg Ala Glu Gly Leu Glu Cys 
        35                  40                  45              


Thr Lys Thr Cys Gln Asn Tyr Asp Leu Glu Cys Met Ser Met Gly Cys 
    50                  55                  60                  


Val Ser Gly Cys Leu Cys Pro Pro Gly Met Val Arg His Glu Asn Arg 
65                  70                  75                  80  


Cys Val Ala Leu Glu Arg Cys Pro Cys Phe His Gln Gly Lys Glu Tyr 
                85                  90                  95      


Ala Pro Gly Glu Thr Val Lys Ile Gly Cys Asn Thr Cys Val Cys Arg 
            100                 105                 110         


Asp Arg Lys Trp Asn Cys Thr Asp His Val Cys Asp Ala Thr Cys Ser 
        115                 120                 125             


Thr Ile Gly Met Ala His Tyr Leu Thr Phe Asp Gly Leu Lys Tyr Leu 
    130                 135                 140                 


Phe Pro Gly Glu Cys Gln Tyr Val Leu Val Gln Asp Tyr Cys Gly Ser 
145                 150                 155                 160 


Asn Pro Gly Thr Phe Arg Ile Leu Val Gly Asn Lys Gly Cys Ser His 
                165                 170                 175     


Pro Ser Val Lys Cys Lys Lys Arg Val Thr Ile Leu Val Glu Gly Gly 
            180                 185                 190         


Glu Ile Glu Leu Phe Asp Gly Glu Val Asn Val Lys Arg Pro Met Lys 
        195                 200                 205             


Asp Glu Thr His Phe Glu Val Val Glu Ser Gly Arg Tyr Ile Ile Leu 
    210                 215                 220                 


Leu Leu Gly Lys Ala Leu Ser Val Val Trp Asp Arg His Leu Ser Ile 
225                 230                 235                 240 


Ser Val Val Leu Lys Gln Thr Tyr Gln Glu Lys Val Cys Gly Leu Cys 
                245                 250                 255     


Gly Asn Phe Asp Gly Ile Gln Asn Asn Asp Leu Thr Ser Ser Asn Leu 
            260                 265                 270         


Gln Val Glu Glu Asp Pro Val Asp Phe Gly Asn Ser Trp Lys Val Ser 
        275                 280                 285             


Ser Gln Cys Ala Asp Thr Arg Lys Val Pro Leu Asp Ser Ser Pro Ala 
    290                 295                 300                 


Thr Cys His Asn Asn Ile Met Lys Gln Thr Met Val Asp Ser Ser Cys 
305                 310                 315                 320 


Arg Ile Leu Thr Ser Asp Val Phe Gln Asp Cys Asn Lys Leu Val Asp 
                325                 330                 335     


Pro Glu Pro Tyr Leu Asp Val Cys Ile Tyr Asp Thr Cys Ser Cys Glu 
            340                 345                 350         


Ser Ile Gly Asp Cys Ala Cys Phe Cys Asp Thr Ile Ala Ala Tyr Ala 
        355                 360                 365             


His Val Cys Ala Gln His Gly Lys Val Val Thr Trp Arg Thr Ala Thr 
    370                 375                 380                 


Leu Cys Pro Gln Ser Cys Glu Glu Arg Asn Leu Arg Glu Asn Gly Tyr 
385                 390                 395                 400 


Glu Cys Glu Trp Arg Tyr Asn Ser Cys Ala Pro Ala Cys Gln Val Thr 
                405                 410                 415     


Cys Gln His Pro Glu Pro Leu Ala Cys Pro Val Gln Cys Val Glu Gly 
            420                 425                 430         


Cys His Ala His Cys Pro Pro Gly Lys Ile Leu Asp Glu Leu Leu Gln 
        435                 440                 445             


Thr Cys Val Asp Pro Glu Asp Cys Pro Val Cys Glu Val Ala Gly Arg 
    450                 455                 460                 


Arg Phe Ala Ser Gly Lys Lys Val Thr Leu Asn Pro Ser Asp Pro Glu 
465                 470                 475                 480 


His Cys Gln Ile Cys His Cys Asp Val Val Asn Leu Thr Cys Glu Ala 
                485                 490                 495     


Cys Gln Glu Pro Gly Gly Leu Val Val Pro Pro Thr Asp Ala Pro Val 
            500                 505                 510         


Ser Pro Thr Thr Leu Tyr Val Glu Asp Ile Ser Glu Pro Pro Leu His 
        515                 520                 525             


Asp Phe Tyr Cys Ser Arg Leu Leu Asp Leu Val Phe Leu Leu Asp Gly 
    530                 535                 540                 


Ser Ser Arg Leu Ser Glu Ala Glu Phe Glu Val Leu Lys Ala Phe Val 
545                 550                 555                 560 


Val Asp Met Met Glu Arg Leu Arg Ile Ser Gln Lys Trp Val Arg Val 
                565                 570                 575     


Ala Val Val Glu Tyr His Asp Gly Ser His Ala Tyr Ile Gly Leu Lys 
            580                 585                 590         


Asp Arg Lys Arg Pro Ser Glu Leu Arg Arg Ile Ala Ser Gln Val Lys 
        595                 600                 605             


Tyr Ala Gly Ser Gln Val Ala Ser Thr Ser Glu Val Leu Lys Tyr Thr 
    610                 615                 620                 


Leu Phe Gln Ile Phe Ser Lys Ile Asp Arg Pro Glu Ala Ser Arg Ile 
625                 630                 635                 640 


Ala Leu Leu Leu Met Ala Ser Gln Glu Pro Gln Arg Met Ser Arg Asn 
                645                 650                 655     


Phe Val Arg Tyr Val Gln Gly Leu Lys Lys Lys Lys Val Ile Val Ile 
            660                 665                 670         


Pro Val Gly Ile Gly Pro His Ala Asn Leu Lys Gln Ile Arg Leu Ile 
        675                 680                 685             


Glu Lys Gln Ala Pro Glu Asn Lys Ala Phe Val Leu Ser Ser Val Asp 
    690                 695                 700                 


Glu Leu Glu Gln Gln Arg Asp Glu Ile Val Ser Tyr Leu Cys Asp Leu 
705                 710                 715                 720 


Ala Pro Glu Ala Pro Pro Pro Thr Leu Pro Pro His Met Ala Gln Val 
                725                 730                 735     


Thr Val Gly Pro Gly Leu Leu Gly Val Ser Thr Leu Gly Pro Lys Arg 
            740                 745                 750         


Asn Ser Met Val Leu Asp Val Ala Phe Val Leu Glu Gly Ser Asp Lys 
        755                 760                 765             


Ile Gly Glu Ala Asp Phe Asn Arg Ser Lys Glu Phe Met Glu Glu Val 
    770                 775                 780                 


Ile Gln Arg Met Asp Val Gly Gln Asp Ser Ile His Val Thr Val Leu 
785                 790                 795                 800 


Gln Tyr Ser Tyr Met Val Thr Val Glu Tyr Pro Phe Ser Glu Ala Gln 
                805                 810                 815     


Ser Lys Gly Asp Ile Leu Gln Arg Val Arg Glu Ile Arg Tyr Gln Gly 
            820                 825                 830         


Gly Asn Arg Thr Asn Thr Gly Leu Ala Leu Arg Tyr Leu Ser Asp His 
        835                 840                 845             


Ser Phe Leu Val Ser Gln Gly Asp Arg Glu Gln Ala Pro Asn Leu Val 
    850                 855                 860                 


Tyr Met Val Thr Gly Asn Pro Ala Ser Asp Glu Ile Lys Arg Leu Pro 
865                 870                 875                 880 


Gly Asp Ile Gln Val Val Pro Ile Gly Val Gly Pro Asn Ala Asn Val 
                885                 890                 895     


Gln Glu Leu Glu Arg Ile Gly Trp Pro Asn Ala Pro Ile Leu Ile Gln 
            900                 905                 910         


Asp Phe Glu Thr Leu Pro Arg Glu Ala Pro Asp Leu Val Leu Gln Arg 
        915                 920                 925             


Cys Cys Ser Gly Glu Gly Leu Gln Ile Pro Thr Leu Ser Pro Ala Pro 
    930                 935                 940                 


Asp Cys Ser Gln Pro Leu Asp Val Ile Leu Leu Leu Asp Gly Ser Ser 
945                 950                 955                 960 


Ser Phe Pro Ala Ser Tyr Phe Asp Glu Met Lys Ser Phe Ala Lys Ala 
                965                 970                 975     


Phe Ile Ser Lys Ala Asn Ile Gly Pro Arg Leu Thr Gln Val Ser Val 
            980                 985                 990         


Leu Gln Tyr Gly Ser Ile Thr Thr  Ile Asp Val Pro Trp  Asn Val Val 
        995                 1000                 1005             


Pro Glu  Lys Ala His Leu Leu  Ser Leu Val Asp Val  Met Gln Arg 
    1010                 1015                 1020             


Glu Gly  Gly Pro Ser Gln Ile  Gly Asp Ala Leu Gly  Phe Ala Val 
    1025                 1030                 1035             


Arg Tyr  Leu Thr Ser Glu Met  His Gly Ala Arg Pro  Gly Ala Ser 
    1040                 1045                 1050             


Lys Ala  Val Val Ile Leu Val  Thr Asp Val Ser Val  Asp Ser Val 
    1055                 1060                 1065             


Asp Ala  Ala Ala Asp Ala Ala  Arg Ser Asn Arg Val  Thr Val Phe 
    1070                 1075                 1080             


Pro Ile  Gly Ile Gly Asp Arg  Tyr Asp Ala Ala Gln  Leu Arg Ile 
    1085                 1090                 1095             


Leu Ala  Gly Pro Ala Gly Asp  Ser Asn Val Val Lys  Leu Gln Arg 
    1100                 1105                 1110             


Ile Glu  Asp Leu Pro Thr Met  Val Thr Leu Gly Asn  Ser Phe Leu 
    1115                 1120                 1125             


His Lys  Leu Cys Ser Gly Phe  Val Arg Ile Cys 
    1130                 1135                 


<210>  10
<211>  1225
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  sequence

<400>  10

Ala Glu Gly Thr Arg Gly Arg Ser Ser Thr Ala Arg Cys Ser Leu Phe 
1               5                   10                  15      


Gly Ser Asp Phe Val Asn Thr Phe Asp Gly Ser Met Tyr Ser Phe Ala 
            20                  25                  30          


Gly Tyr Cys Ser Tyr Leu Leu Ala Gly Gly Cys Gln Lys Arg Ser Phe 
        35                  40                  45              


Ser Ile Ile Gly Asp Phe Gln Asn Gly Lys Arg Val Ser Leu Ser Val 
    50                  55                  60                  


Tyr Leu Gly Glu Phe Phe Asp Ile His Leu Phe Val Asn Gly Thr Val 
65                  70                  75                  80  


Thr Gln Gly Asp Gln Arg Val Ser Met Pro Tyr Ala Ser Lys Gly Leu 
                85                  90                  95      


Tyr Leu Glu Thr Glu Ala Gly Tyr Tyr Lys Leu Ser Gly Glu Ala Tyr 
            100                 105                 110         


Gly Phe Val Ala Arg Ile Asp Gly Ser Gly Asn Phe Gln Val Leu Leu 
        115                 120                 125             


Ser Asp Arg Tyr Phe Asn Lys Thr Cys Gly Leu Cys Gly Asn Phe Asn 
    130                 135                 140                 


Ile Phe Ala Glu Asp Asp Phe Met Thr Gln Glu Gly Thr Leu Thr Ser 
145                 150                 155                 160 


Asp Pro Tyr Asp Phe Ala Asn Ser Trp Ala Leu Ser Ser Gly Glu Gln 
                165                 170                 175     


Trp Cys Glu Arg Ala Ser Pro Pro Ser Ser Ser Cys Asn Ile Ser Ser 
            180                 185                 190         


Gly Glu Met Gln Lys Gly Leu Trp Glu Gln Cys Gln Leu Leu Lys Ser 
        195                 200                 205             


Thr Ser Val Phe Ala Arg Cys His Pro Leu Val Asp Pro Glu Pro Phe 
    210                 215                 220                 


Val Ala Leu Cys Glu Lys Thr Leu Cys Glu Cys Ala Gly Gly Leu Glu 
225                 230                 235                 240 


Cys Ala Cys Pro Ala Leu Leu Glu Tyr Ala Arg Thr Cys Ala Gln Glu 
                245                 250                 255     


Gly Met Val Leu Tyr Gly Trp Thr Asp His Ser Ala Cys Ser Pro Val 
            260                 265                 270         


Cys Pro Ala Gly Met Glu Tyr Arg Gln Cys Val Ser Pro Cys Ala Arg 
        275                 280                 285             


Thr Cys Gln Ser Leu His Ile Asn Glu Met Cys Gln Glu Arg Cys Val 
    290                 295                 300                 


Asp Gly Cys Ser Cys Pro Glu Gly Gln Leu Leu Asp Glu Gly Leu Cys 
305                 310                 315                 320 


Val Glu Ser Thr Glu Cys Pro Cys Val His Ser Gly Lys Arg Tyr Pro 
                325                 330                 335     


Pro Gly Thr Ser Leu Ser Arg Asp Cys Asn Thr Cys Ile Cys Arg Asn 
            340                 345                 350         


Ser Gln Trp Ile Cys Ser Asn Glu Glu Cys Pro Gly Glu Cys Leu Val 
        355                 360                 365             


Thr Gly Gln Ser His Phe Lys Ser Phe Asp Asn Arg Tyr Phe Thr Phe 
    370                 375                 380                 


Ser Gly Ile Cys Gln Tyr Leu Leu Ala Arg Asp Cys Gln Asp His Ser 
385                 390                 395                 400 


Phe Ser Ile Val Ile Glu Thr Val Gln Cys Ala Asp Asp Arg Asp Ala 
                405                 410                 415     


Val Cys Thr Arg Ser Val Thr Val Arg Leu Pro Gly Leu His Asn Ser 
            420                 425                 430         


Leu Val Lys Leu Lys His Gly Ala Gly Val Ala Met Asp Gly Gln Asp 
        435                 440                 445             


Ile Gln Leu Pro Leu Leu Lys Gly Asp Leu Arg Ile Gln His Thr Val 
    450                 455                 460                 


Thr Ala Ser Val Arg Leu Ser Tyr Gly Glu Asp Leu Gln Met Asp Trp 
465                 470                 475                 480 


Asp Gly Arg Gly Arg Leu Leu Val Lys Leu Ser Pro Val Tyr Ala Gly 
                485                 490                 495     


Lys Thr Cys Gly Leu Cys Gly Asn Tyr Asn Gly Asn Gln Gly Asp Asp 
            500                 505                 510         


Phe Leu Thr Pro Ser Gly Leu Ala Glu Pro Arg Val Glu Asp Phe Gly 
        515                 520                 525             


Asn Ala Trp Lys Leu His Gly Asp Cys Gln Asp Leu Gln Lys Gln His 
    530                 535                 540                 


Ser Asp Pro Cys Ala Leu Asn Pro Arg Met Thr Arg Phe Ser Glu Glu 
545                 550                 555                 560 


Ala Cys Ala Val Leu Thr Ser Pro Thr Phe Glu Ala Cys His Arg Ala 
                565                 570                 575     


Val Ser Pro Leu Pro Tyr Leu Arg Asn Cys Arg Tyr Asp Val Cys Ser 
            580                 585                 590         


Cys Ser Asp Gly Arg Glu Cys Leu Cys Gly Ala Leu Ala Ser Tyr Ala 
        595                 600                 605             


Ala Ala Cys Ala Gly Arg Gly Val Arg Val Ala Trp Arg Glu Pro Gly 
    610                 615                 620                 


Arg Cys Glu Leu Asn Cys Pro Lys Gly Gln Val Tyr Leu Gln Cys Gly 
625                 630                 635                 640 


Thr Pro Cys Asn Leu Thr Cys Arg Ser Leu Ser Tyr Pro Asp Glu Glu 
                645                 650                 655     


Cys Asn Glu Ala Cys Leu Glu Gly Cys Phe Cys Pro Pro Gly Leu Tyr 
            660                 665                 670         


Met Asp Glu Arg Gly Asp Cys Val Pro Lys Ala Gln Cys Pro Cys Tyr 
        675                 680                 685             


Tyr Asp Gly Glu Ile Phe Gln Pro Glu Asp Ile Phe Ser Asp His His 
    690                 695                 700                 


Thr Met Cys Tyr Cys Glu Asp Gly Phe Met His Cys Thr Met Ser Gly 
705                 710                 715                 720 


Val Pro Gly Ser Leu Leu Pro Asp Ala Val Leu Ser Ser Pro Leu Ser 
                725                 730                 735     


His Arg Ser Lys Arg Ser Leu Ser Cys Arg Pro Pro Met Val Lys Leu 
            740                 745                 750         


Val Cys Pro Ala Asp Asn Leu Arg Ala Glu Gly Leu Glu Cys Thr Lys 
        755                 760                 765             


Thr Cys Gln Asn Tyr Asp Leu Glu Cys Met Ser Met Gly Cys Val Ser 
    770                 775                 780                 


Gly Cys Leu Cys Pro Pro Gly Met Val Arg His Glu Asn Arg Cys Val 
785                 790                 795                 800 


Ala Leu Glu Arg Cys Pro Cys Phe His Gln Gly Lys Glu Tyr Ala Pro 
                805                 810                 815     


Gly Glu Thr Val Lys Ile Gly Cys Asn Thr Cys Val Cys Arg Asp Arg 
            820                 825                 830         


Lys Trp Asn Cys Thr Asp His Val Cys Asp Ala Thr Cys Ser Thr Ile 
        835                 840                 845             


Gly Met Ala His Tyr Leu Thr Phe Asp Gly Leu Lys Tyr Leu Phe Pro 
    850                 855                 860                 


Gly Glu Cys Gln Tyr Val Leu Val Gln Asp Tyr Cys Gly Ser Asn Pro 
865                 870                 875                 880 


Gly Thr Phe Arg Ile Leu Val Gly Asn Lys Gly Cys Ser His Pro Ser 
                885                 890                 895     


Val Lys Cys Lys Lys Arg Val Thr Ile Leu Val Glu Gly Gly Glu Ile 
            900                 905                 910         


Glu Leu Phe Asp Gly Glu Val Asn Val Lys Arg Pro Met Lys Asp Glu 
        915                 920                 925             


Thr His Phe Glu Val Val Glu Ser Gly Arg Tyr Ile Ile Leu Leu Leu 
    930                 935                 940                 


Gly Lys Ala Leu Ser Val Val Trp Asp Arg His Leu Ser Ile Ser Val 
945                 950                 955                 960 


Val Leu Lys Gln Thr Tyr Gln Glu Lys Val Cys Gly Leu Cys Gly Asn 
                965                 970                 975     


Phe Asp Gly Ile Gln Asn Asn Asp Leu Thr Ser Ser Asn Leu Gln Val 
            980                 985                 990         


Glu Glu Asp Pro Val Asp Phe Gly  Asn Ser Trp Lys Val  Ser Ser Gln 
        995                 1000                 1005             


Cys Ala  Asp Thr Arg Lys Val  Pro Leu Asp Ser Ser  Pro Ala Thr 
    1010                 1015                 1020             


Cys His  Asn Asn Ile Met Lys  Gln Thr Met Val Asp  Ser Ser Cys 
    1025                 1030                 1035             


Arg Ile  Leu Thr Ser Asp Val  Phe Gln Asp Cys Asn  Lys Leu Val 
    1040                 1045                 1050             


Asp Pro  Glu Pro Tyr Leu Asp  Val Cys Ile Tyr Asp  Thr Cys Ser 
    1055                 1060                 1065             


Cys Glu  Ser Ile Gly Asp Cys  Ala Cys Phe Cys Asp  Thr Ile Ala 
    1070                 1075                 1080             


Ala Tyr  Ala His Val Cys Ala  Gln His Gly Lys Val  Val Thr Trp 
    1085                 1090                 1095             


Arg Thr  Ala Thr Leu Cys Pro  Gln Ser Cys Glu Glu  Arg Asn Leu 
    1100                 1105                 1110             


Arg Glu  Asn Gly Tyr Glu Cys  Glu Trp Arg Tyr Asn  Ser Cys Ala 
    1115                 1120                 1125             


Pro Ala  Cys Gln Val Thr Cys  Gln His Pro Glu Pro  Leu Ala Cys 
    1130                 1135                 1140             


Pro Val  Gln Cys Val Glu Gly  Cys His Ala His Cys  Pro Pro Gly 
    1145                 1150                 1155             


Lys Ile  Leu Asp Glu Leu Leu  Gln Thr Cys Val Asp  Pro Glu Asp 
    1160                 1165                 1170             


Cys Pro  Val Cys Glu Val Ala  Gly Arg Arg Phe Ala  Ser Gly Lys 
    1175                 1180                 1185             


Lys Val  Thr Leu Asn Pro Ser  Asp Pro Glu His Cys  Gln Ile Cys 
    1190                 1195                 1200             


His Cys  Asp Val Val Asn Leu  Thr Cys Glu Ala Cys  Gln Glu Pro 
    1205                 1210                 1215             


Gly Gly  Leu Val Val Pro Pro  
    1220                 1225 


<210>  11
<211>  1247
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  sequence

<400>  11

Met Ile Pro Ala Arg Phe Ala Gly Val Leu Leu Ala Leu Ala Leu Ile 
1               5                   10                  15      


Leu Pro Gly Thr Leu Cys Ala Glu Gly Thr Arg Gly Arg Ser Ser Thr 
            20                  25                  30          


Ala Arg Cys Ser Leu Phe Gly Ser Asp Phe Val Asn Thr Phe Asp Gly 
        35                  40                  45              


Ser Met Tyr Ser Phe Ala Gly Tyr Cys Ser Tyr Leu Leu Ala Gly Gly 
    50                  55                  60                  


Cys Gln Lys Arg Ser Phe Ser Ile Ile Gly Asp Phe Gln Asn Gly Lys 
65                  70                  75                  80  


Arg Val Ser Leu Ser Val Tyr Leu Gly Glu Phe Phe Asp Ile His Leu 
                85                  90                  95      


Phe Val Asn Gly Thr Val Thr Gln Gly Asp Gln Arg Val Ser Met Pro 
            100                 105                 110         


Tyr Ala Ser Lys Gly Leu Tyr Leu Glu Thr Glu Ala Gly Tyr Tyr Lys 
        115                 120                 125             


Leu Ser Gly Glu Ala Tyr Gly Phe Val Ala Arg Ile Asp Gly Ser Gly 
    130                 135                 140                 


Asn Phe Gln Val Leu Leu Ser Asp Arg Tyr Phe Asn Lys Thr Cys Gly 
145                 150                 155                 160 


Leu Cys Gly Asn Phe Asn Ile Phe Ala Glu Asp Asp Phe Met Thr Gln 
                165                 170                 175     


Glu Gly Thr Leu Thr Ser Asp Pro Tyr Asp Phe Ala Asn Ser Trp Ala 
            180                 185                 190         


Leu Ser Ser Gly Glu Gln Trp Cys Glu Arg Ala Ser Pro Pro Ser Ser 
        195                 200                 205             


Ser Cys Asn Ile Ser Ser Gly Glu Met Gln Lys Gly Leu Trp Glu Gln 
    210                 215                 220                 


Cys Gln Leu Leu Lys Ser Thr Ser Val Phe Ala Arg Cys His Pro Leu 
225                 230                 235                 240 


Val Asp Pro Glu Pro Phe Val Ala Leu Cys Glu Lys Thr Leu Cys Glu 
                245                 250                 255     


Cys Ala Gly Gly Leu Glu Cys Ala Cys Pro Ala Leu Leu Glu Tyr Ala 
            260                 265                 270         


Arg Thr Cys Ala Gln Glu Gly Met Val Leu Tyr Gly Trp Thr Asp His 
        275                 280                 285             


Ser Ala Cys Ser Pro Val Cys Pro Ala Gly Met Glu Tyr Arg Gln Cys 
    290                 295                 300                 


Val Ser Pro Cys Ala Arg Thr Cys Gln Ser Leu His Ile Asn Glu Met 
305                 310                 315                 320 


Cys Gln Glu Arg Cys Val Asp Gly Cys Ser Cys Pro Glu Gly Gln Leu 
                325                 330                 335     


Leu Asp Glu Gly Leu Cys Val Glu Ser Thr Glu Cys Pro Cys Val His 
            340                 345                 350         


Ser Gly Lys Arg Tyr Pro Pro Gly Thr Ser Leu Ser Arg Asp Cys Asn 
        355                 360                 365             


Thr Cys Ile Cys Arg Asn Ser Gln Trp Ile Cys Ser Asn Glu Glu Cys 
    370                 375                 380                 


Pro Gly Glu Cys Leu Val Thr Gly Gln Ser His Phe Lys Ser Phe Asp 
385                 390                 395                 400 


Asn Arg Tyr Phe Thr Phe Ser Gly Ile Cys Gln Tyr Leu Leu Ala Arg 
                405                 410                 415     


Asp Cys Gln Asp His Ser Phe Ser Ile Val Ile Glu Thr Val Gln Cys 
            420                 425                 430         


Ala Asp Asp Arg Asp Ala Val Cys Thr Arg Ser Val Thr Val Arg Leu 
        435                 440                 445             


Pro Gly Leu His Asn Ser Leu Val Lys Leu Lys His Gly Ala Gly Val 
    450                 455                 460                 


Ala Met Asp Gly Gln Asp Ile Gln Leu Pro Leu Leu Lys Gly Asp Leu 
465                 470                 475                 480 


Arg Ile Gln His Thr Val Thr Ala Ser Val Arg Leu Ser Tyr Gly Glu 
                485                 490                 495     


Asp Leu Gln Met Asp Trp Asp Gly Arg Gly Arg Leu Leu Val Lys Leu 
            500                 505                 510         


Ser Pro Val Tyr Ala Gly Lys Thr Cys Gly Leu Cys Gly Asn Tyr Asn 
        515                 520                 525             


Gly Asn Gln Gly Asp Asp Phe Leu Thr Pro Ser Gly Leu Ala Glu Pro 
    530                 535                 540                 


Arg Val Glu Asp Phe Gly Asn Ala Trp Lys Leu His Gly Asp Cys Gln 
545                 550                 555                 560 


Asp Leu Gln Lys Gln His Ser Asp Pro Cys Ala Leu Asn Pro Arg Met 
                565                 570                 575     


Thr Arg Phe Ser Glu Glu Ala Cys Ala Val Leu Thr Ser Pro Thr Phe 
            580                 585                 590         


Glu Ala Cys His Arg Ala Val Ser Pro Leu Pro Tyr Leu Arg Asn Cys 
        595                 600                 605             


Arg Tyr Asp Val Cys Ser Cys Ser Asp Gly Arg Glu Cys Leu Cys Gly 
    610                 615                 620                 


Ala Leu Ala Ser Tyr Ala Ala Ala Cys Ala Gly Arg Gly Val Arg Val 
625                 630                 635                 640 


Ala Trp Arg Glu Pro Gly Arg Cys Glu Leu Asn Cys Pro Lys Gly Gln 
                645                 650                 655     


Val Tyr Leu Gln Cys Gly Thr Pro Cys Asn Leu Thr Cys Arg Ser Leu 
            660                 665                 670         


Ser Tyr Pro Asp Glu Glu Cys Asn Glu Ala Cys Leu Glu Gly Cys Phe 
        675                 680                 685             


Cys Pro Pro Gly Leu Tyr Met Asp Glu Arg Gly Asp Cys Val Pro Lys 
    690                 695                 700                 


Ala Gln Cys Pro Cys Tyr Tyr Asp Gly Glu Ile Phe Gln Pro Glu Asp 
705                 710                 715                 720 


Ile Phe Ser Asp His His Thr Met Cys Tyr Cys Glu Asp Gly Phe Met 
                725                 730                 735     


His Cys Thr Met Ser Gly Val Pro Gly Ser Leu Leu Pro Asp Ala Val 
            740                 745                 750         


Leu Ser Ser Pro Leu Ser His Arg Ser Lys Arg Ser Leu Ser Cys Arg 
        755                 760                 765             


Pro Pro Met Val Lys Leu Val Cys Pro Ala Asp Asn Leu Arg Ala Glu 
    770                 775                 780                 


Gly Leu Glu Cys Thr Lys Thr Cys Gln Asn Tyr Asp Leu Glu Cys Met 
785                 790                 795                 800 


Ser Met Gly Cys Val Ser Gly Cys Leu Cys Pro Pro Gly Met Val Arg 
                805                 810                 815     


His Glu Asn Arg Cys Val Ala Leu Glu Arg Cys Pro Cys Phe His Gln 
            820                 825                 830         


Gly Lys Glu Tyr Ala Pro Gly Glu Thr Val Lys Ile Gly Cys Asn Thr 
        835                 840                 845             


Cys Val Cys Arg Asp Arg Lys Trp Asn Cys Thr Asp His Val Cys Asp 
    850                 855                 860                 


Ala Thr Cys Ser Thr Ile Gly Met Ala His Tyr Leu Thr Phe Asp Gly 
865                 870                 875                 880 


Leu Lys Tyr Leu Phe Pro Gly Glu Cys Gln Tyr Val Leu Val Gln Asp 
                885                 890                 895     


Tyr Cys Gly Ser Asn Pro Gly Thr Phe Arg Ile Leu Val Gly Asn Lys 
            900                 905                 910         


Gly Cys Ser His Pro Ser Val Lys Cys Lys Lys Arg Val Thr Ile Leu 
        915                 920                 925             


Val Glu Gly Gly Glu Ile Glu Leu Phe Asp Gly Glu Val Asn Val Lys 
    930                 935                 940                 


Arg Pro Met Lys Asp Glu Thr His Phe Glu Val Val Glu Ser Gly Arg 
945                 950                 955                 960 


Tyr Ile Ile Leu Leu Leu Gly Lys Ala Leu Ser Val Val Trp Asp Arg 
                965                 970                 975     


His Leu Ser Ile Ser Val Val Leu Lys Gln Thr Tyr Gln Glu Lys Val 
            980                 985                 990         


Cys Gly Leu Cys Gly Asn Phe Asp  Gly Ile Gln Asn Asn  Asp Leu Thr 
        995                 1000                 1005             


Ser Ser  Asn Leu Gln Val Glu  Glu Asp Pro Val Asp  Phe Gly Asn 
    1010                 1015                 1020             


Ser Trp  Lys Val Ser Ser Gln  Cys Ala Asp Thr Arg  Lys Val Pro 
    1025                 1030                 1035             


Leu Asp  Ser Ser Pro Ala Thr  Cys His Asn Asn Ile  Met Lys Gln 
    1040                 1045                 1050             


Thr Met  Val Asp Ser Ser Cys  Arg Ile Leu Thr Ser  Asp Val Phe 
    1055                 1060                 1065             


Gln Asp  Cys Asn Lys Leu Val  Asp Pro Glu Pro Tyr  Leu Asp Val 
    1070                 1075                 1080             


Cys Ile  Tyr Asp Thr Cys Ser  Cys Glu Ser Ile Gly  Asp Cys Ala 
    1085                 1090                 1095             


Cys Phe  Cys Asp Thr Ile Ala  Ala Tyr Ala His Val  Cys Ala Gln 
    1100                 1105                 1110             


His Gly  Lys Val Val Thr Trp  Arg Thr Ala Thr Leu  Cys Pro Gln 
    1115                 1120                 1125             


Ser Cys  Glu Glu Arg Asn Leu  Arg Glu Asn Gly Tyr  Glu Cys Glu 
    1130                 1135                 1140             


Trp Arg  Tyr Asn Ser Cys Ala  Pro Ala Cys Gln Val  Thr Cys Gln 
    1145                 1150                 1155             


His Pro  Glu Pro Leu Ala Cys  Pro Val Gln Cys Val  Glu Gly Cys 
    1160                 1165                 1170             


His Ala  His Cys Pro Pro Gly  Lys Ile Leu Asp Glu  Leu Leu Gln 
    1175                 1180                 1185             


Thr Cys  Val Asp Pro Glu Asp  Cys Pro Val Cys Glu  Val Ala Gly 
    1190                 1195                 1200             


Arg Arg  Phe Ala Ser Gly Lys  Lys Val Thr Leu Asn  Pro Ser Asp 
    1205                 1210                 1215             


Pro Glu  His Cys Gln Ile Cys  His Cys Asp Val Val  Asn Leu Thr 
    1220                 1225                 1230             


Cys Glu  Ala Cys Gln Glu Pro  Gly Gly Leu Val Val  Pro Pro 
    1235                 1240                 1245         


<210>  12
<211>  1459
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  sequence

<400>  12

Ala Glu Gly Thr Arg Gly Arg Ser Ser Thr Ala Arg Cys Ser Leu Phe 
1               5                   10                  15      


Gly Ser Asp Phe Val Asn Thr Phe Asp Gly Ser Met Tyr Ser Phe Ala 
            20                  25                  30          


Gly Tyr Cys Ser Tyr Leu Leu Ala Gly Gly Cys Gln Lys Arg Ser Phe 
        35                  40                  45              


Ser Ile Ile Gly Asp Phe Gln Asn Gly Lys Arg Val Ser Leu Ser Val 
    50                  55                  60                  


Tyr Leu Gly Glu Phe Phe Asp Ile His Leu Phe Val Asn Gly Thr Val 
65                  70                  75                  80  


Thr Gln Gly Asp Gln Arg Val Ser Met Pro Tyr Ala Ser Lys Gly Leu 
                85                  90                  95      


Tyr Leu Glu Thr Glu Ala Gly Tyr Tyr Lys Leu Ser Gly Glu Ala Tyr 
            100                 105                 110         


Gly Phe Val Ala Arg Ile Asp Gly Ser Gly Asn Phe Gln Val Leu Leu 
        115                 120                 125             


Ser Asp Arg Tyr Phe Asn Lys Thr Cys Gly Leu Cys Gly Asn Phe Asn 
    130                 135                 140                 


Ile Phe Ala Glu Asp Asp Phe Met Thr Gln Glu Gly Thr Leu Thr Ser 
145                 150                 155                 160 


Asp Pro Tyr Asp Phe Ala Asn Ser Trp Ala Leu Ser Ser Gly Glu Gln 
                165                 170                 175     


Trp Cys Glu Arg Ala Ser Pro Pro Ser Ser Ser Cys Asn Ile Ser Ser 
            180                 185                 190         


Gly Glu Met Gln Lys Gly Leu Trp Glu Gln Cys Gln Leu Leu Lys Ser 
        195                 200                 205             


Thr Ser Val Phe Ala Arg Cys His Pro Leu Val Asp Pro Glu Pro Phe 
    210                 215                 220                 


Val Ala Leu Cys Glu Lys Thr Leu Cys Glu Cys Ala Gly Gly Leu Glu 
225                 230                 235                 240 


Cys Ala Cys Pro Ala Leu Leu Glu Tyr Ala Arg Thr Cys Ala Gln Glu 
                245                 250                 255     


Gly Met Val Leu Tyr Gly Trp Thr Asp His Ser Ala Cys Ser Pro Val 
            260                 265                 270         


Cys Pro Ala Gly Met Glu Tyr Arg Gln Cys Val Ser Pro Cys Ala Arg 
        275                 280                 285             


Thr Cys Gln Ser Leu His Ile Asn Glu Met Cys Gln Glu Arg Cys Val 
    290                 295                 300                 


Asp Gly Cys Ser Cys Pro Glu Gly Gln Leu Leu Asp Glu Gly Leu Cys 
305                 310                 315                 320 


Val Glu Ser Thr Glu Cys Pro Cys Val His Ser Gly Lys Arg Tyr Pro 
                325                 330                 335     


Pro Gly Thr Ser Leu Ser Arg Asp Cys Asn Thr Cys Ile Cys Arg Asn 
            340                 345                 350         


Ser Gln Trp Ile Cys Ser Asn Glu Glu Cys Pro Gly Glu Cys Leu Val 
        355                 360                 365             


Thr Gly Gln Ser His Phe Lys Ser Phe Asp Asn Arg Tyr Phe Thr Phe 
    370                 375                 380                 


Ser Gly Ile Cys Gln Tyr Leu Leu Ala Arg Asp Cys Gln Asp His Ser 
385                 390                 395                 400 


Phe Ser Ile Val Ile Glu Thr Val Gln Cys Ala Asp Asp Arg Asp Ala 
                405                 410                 415     


Val Cys Thr Arg Ser Val Thr Val Arg Leu Pro Gly Leu His Asn Ser 
            420                 425                 430         


Leu Val Lys Leu Lys His Gly Ala Gly Val Ala Met Asp Gly Gln Asp 
        435                 440                 445             


Ile Gln Leu Pro Leu Leu Lys Gly Asp Leu Arg Ile Gln His Thr Val 
    450                 455                 460                 


Thr Ala Ser Val Arg Leu Ser Tyr Gly Glu Asp Leu Gln Met Asp Trp 
465                 470                 475                 480 


Asp Gly Arg Gly Arg Leu Leu Val Lys Leu Ser Pro Val Tyr Ala Gly 
                485                 490                 495     


Lys Thr Cys Gly Leu Cys Gly Asn Tyr Asn Gly Asn Gln Gly Asp Asp 
            500                 505                 510         


Phe Leu Thr Pro Ser Gly Leu Ala Glu Pro Arg Val Glu Asp Phe Gly 
        515                 520                 525             


Asn Ala Trp Lys Leu His Gly Asp Cys Gln Asp Leu Gln Lys Gln His 
    530                 535                 540                 


Ser Asp Pro Cys Ala Leu Asn Pro Arg Met Thr Arg Phe Ser Glu Glu 
545                 550                 555                 560 


Ala Cys Ala Val Leu Thr Ser Pro Thr Phe Glu Ala Cys His Arg Ala 
                565                 570                 575     


Val Ser Pro Leu Pro Tyr Leu Arg Asn Cys Arg Tyr Asp Val Cys Ser 
            580                 585                 590         


Cys Ser Asp Gly Arg Glu Cys Leu Cys Gly Ala Leu Ala Ser Tyr Ala 
        595                 600                 605             


Ala Ala Cys Ala Gly Arg Gly Val Arg Val Ala Trp Arg Glu Pro Gly 
    610                 615                 620                 


Arg Cys Glu Leu Asn Cys Pro Lys Gly Gln Val Tyr Leu Gln Cys Gly 
625                 630                 635                 640 


Thr Pro Cys Asn Leu Thr Cys Arg Ser Leu Ser Tyr Pro Asp Glu Glu 
                645                 650                 655     


Cys Asn Glu Ala Cys Leu Glu Gly Cys Phe Cys Pro Pro Gly Leu Tyr 
            660                 665                 670         


Met Asp Glu Arg Gly Asp Cys Val Pro Lys Ala Gln Cys Pro Cys Tyr 
        675                 680                 685             


Tyr Asp Gly Glu Ile Phe Gln Pro Glu Asp Ile Phe Ser Asp His His 
    690                 695                 700                 


Thr Met Cys Tyr Cys Glu Asp Gly Phe Met His Cys Thr Met Ser Gly 
705                 710                 715                 720 


Val Pro Gly Ser Leu Leu Pro Asp Ala Val Leu Ser Ser Pro Leu Ser 
                725                 730                 735     


His Arg Ser Lys Arg Ser Leu Ser Cys Arg Pro Pro Met Val Lys Leu 
            740                 745                 750         


Val Cys Pro Ala Asp Asn Leu Arg Ala Glu Gly Leu Glu Cys Thr Lys 
        755                 760                 765             


Thr Cys Gln Asn Tyr Asp Leu Glu Cys Met Ser Met Gly Cys Val Ser 
    770                 775                 780                 


Gly Cys Leu Cys Pro Pro Gly Met Val Arg His Glu Asn Arg Cys Val 
785                 790                 795                 800 


Ala Leu Glu Arg Cys Pro Cys Phe His Gln Gly Lys Glu Tyr Ala Pro 
                805                 810                 815     


Gly Glu Thr Val Lys Ile Gly Cys Asn Thr Cys Val Cys Arg Asp Arg 
            820                 825                 830         


Lys Trp Asn Cys Thr Asp His Val Cys Asp Ala Thr Cys Ser Thr Ile 
        835                 840                 845             


Gly Met Ala His Tyr Leu Thr Phe Asp Gly Leu Lys Tyr Leu Phe Pro 
    850                 855                 860                 


Gly Glu Cys Gln Tyr Val Leu Val Gln Asp Tyr Cys Gly Ser Asn Pro 
865                 870                 875                 880 


Gly Thr Phe Arg Ile Leu Val Gly Asn Lys Gly Cys Ser His Pro Ser 
                885                 890                 895     


Val Lys Cys Lys Lys Arg Val Thr Ile Leu Val Glu Gly Gly Glu Ile 
            900                 905                 910         


Glu Leu Phe Asp Gly Glu Val Asn Val Lys Arg Pro Met Lys Asp Glu 
        915                 920                 925             


Thr His Phe Glu Val Val Glu Ser Gly Arg Tyr Ile Ile Leu Leu Leu 
    930                 935                 940                 


Gly Lys Ala Leu Ser Val Val Trp Asp Arg His Leu Ser Ile Ser Val 
945                 950                 955                 960 


Val Leu Lys Gln Thr Tyr Gln Glu Lys Val Cys Gly Leu Cys Gly Asn 
                965                 970                 975     


Phe Asp Gly Ile Gln Asn Asn Asp Leu Thr Ser Ser Asn Leu Gln Val 
            980                 985                 990         


Glu Glu Asp Pro Val Asp Phe Gly  Asn Ser Trp Lys Val  Ser Ser Gln 
        995                 1000                 1005             


Cys Ala  Asp Thr Arg Lys Val  Pro Leu Asp Ser Ser  Pro Ala Thr 
    1010                 1015                 1020             


Cys His  Asn Asn Ile Met Lys  Gln Thr Met Val Asp  Ser Ser Cys 
    1025                 1030                 1035             


Arg Ile  Leu Thr Ser Asp Val  Phe Gln Asp Cys Asn  Lys Leu Val 
    1040                 1045                 1050             


Asp Pro  Glu Pro Tyr Leu Asp  Val Cys Ile Tyr Asp  Thr Cys Ser 
    1055                 1060                 1065             


Cys Glu  Ser Ile Gly Asp Cys  Ala Cys Phe Cys Asp  Thr Ile Ala 
    1070                 1075                 1080             


Ala Tyr  Ala His Val Cys Ala  Gln His Gly Lys Val  Val Thr Trp 
    1085                 1090                 1095             


Arg Thr  Ala Thr Leu Cys Pro  Gln Ser Cys Glu Glu  Arg Asn Leu 
    1100                 1105                 1110             


Arg Glu  Asn Gly Tyr Glu Cys  Glu Trp Arg Tyr Asn  Ser Cys Ala 
    1115                 1120                 1125             


Pro Ala  Cys Gln Val Thr Cys  Gln His Pro Glu Pro  Leu Ala Cys 
    1130                 1135                 1140             


Pro Val  Gln Cys Val Glu Gly  Cys His Ala His Cys  Pro Pro Gly 
    1145                 1150                 1155             


Lys Ile  Leu Asp Glu Leu Leu  Gln Thr Cys Val Asp  Pro Glu Asp 
    1160                 1165                 1170             


Cys Pro  Val Cys Glu Val Ala  Gly Arg Arg Phe Ala  Ser Gly Lys 
    1175                 1180                 1185             


Lys Val  Thr Leu Asn Pro Ser  Asp Pro Glu His Cys  Gln Ile Cys 
    1190                 1195                 1200             


His Cys  Asp Val Val Asn Leu  Thr Cys Glu Ala Cys  Gln Glu Pro 
    1205                 1210                 1215             


Gly Gly  Leu Val Val Pro Pro  Thr Asp Ala Pro Val  Ser Pro Thr 
    1220                 1225                 1230             


Thr Leu  Tyr Val Glu Asp Ile  Ser Glu Pro Pro Leu  His Asp Phe 
    1235                 1240                 1245             


Tyr Cys  Ser Arg Leu Leu Asp  Leu Val Phe Leu Leu  Asp Gly Ser 
    1250                 1255                 1260             


Ser Arg  Leu Ser Glu Ala Glu  Phe Glu Val Leu Lys  Ala Phe Val 
    1265                 1270                 1275             


Val Asp  Met Met Glu Arg Leu  Arg Ile Ser Gln Lys  Trp Val Arg 
    1280                 1285                 1290             


Val Ala  Val Val Glu Tyr His  Asp Gly Ser His Ala  Tyr Ile Gly 
    1295                 1300                 1305             


Leu Lys  Asp Arg Lys Arg Pro  Ser Glu Leu Arg Arg  Ile Ala Ser 
    1310                 1315                 1320             


Gln Val  Lys Tyr Ala Gly Ser  Gln Val Ala Ser Thr  Ser Glu Val 
    1325                 1330                 1335             


Leu Lys  Tyr Thr Leu Phe Gln  Ile Phe Ser Lys Ile  Asp Arg Pro 
    1340                 1345                 1350             


Glu Ala  Ser Arg Ile Ala Leu  Leu Leu Met Ala Ser  Gln Glu Pro 
    1355                 1360                 1365             


Gln Arg  Met Ser Arg Asn Phe  Val Arg Tyr Val Gln  Gly Leu Lys 
    1370                 1375                 1380             


Lys Lys  Lys Val Ile Val Ile  Pro Val Gly Ile Gly  Pro His Ala 
    1385                 1390                 1395             


Asn Leu  Lys Gln Ile Arg Leu  Ile Glu Lys Gln Ala  Pro Glu Asn 
    1400                 1405                 1410             


Lys Ala  Phe Val Leu Ser Ser  Val Asp Glu Leu Glu  Gln Gln Arg 
    1415                 1420                 1425             


Asp Glu  Ile Val Ser Tyr Leu  Cys Asp Leu Ala Pro  Glu Ala Pro 
    1430                 1435                 1440             


Pro Pro  Thr Leu Pro Pro His  Met Ala Gln Val Thr  Val Gly Pro 
    1445                 1450                 1455             


Gly 
    


<210>  13
<211>  1481
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  sequence

<400>  13

Met Ile Pro Ala Arg Phe Ala Gly Val Leu Leu Ala Leu Ala Leu Ile 
1               5                   10                  15      


Leu Pro Gly Thr Leu Cys Ala Glu Gly Thr Arg Gly Arg Ser Ser Thr 
            20                  25                  30          


Ala Arg Cys Ser Leu Phe Gly Ser Asp Phe Val Asn Thr Phe Asp Gly 
        35                  40                  45              


Ser Met Tyr Ser Phe Ala Gly Tyr Cys Ser Tyr Leu Leu Ala Gly Gly 
    50                  55                  60                  


Cys Gln Lys Arg Ser Phe Ser Ile Ile Gly Asp Phe Gln Asn Gly Lys 
65                  70                  75                  80  


Arg Val Ser Leu Ser Val Tyr Leu Gly Glu Phe Phe Asp Ile His Leu 
                85                  90                  95      


Phe Val Asn Gly Thr Val Thr Gln Gly Asp Gln Arg Val Ser Met Pro 
            100                 105                 110         


Tyr Ala Ser Lys Gly Leu Tyr Leu Glu Thr Glu Ala Gly Tyr Tyr Lys 
        115                 120                 125             


Leu Ser Gly Glu Ala Tyr Gly Phe Val Ala Arg Ile Asp Gly Ser Gly 
    130                 135                 140                 


Asn Phe Gln Val Leu Leu Ser Asp Arg Tyr Phe Asn Lys Thr Cys Gly 
145                 150                 155                 160 


Leu Cys Gly Asn Phe Asn Ile Phe Ala Glu Asp Asp Phe Met Thr Gln 
                165                 170                 175     


Glu Gly Thr Leu Thr Ser Asp Pro Tyr Asp Phe Ala Asn Ser Trp Ala 
            180                 185                 190         


Leu Ser Ser Gly Glu Gln Trp Cys Glu Arg Ala Ser Pro Pro Ser Ser 
        195                 200                 205             


Ser Cys Asn Ile Ser Ser Gly Glu Met Gln Lys Gly Leu Trp Glu Gln 
    210                 215                 220                 


Cys Gln Leu Leu Lys Ser Thr Ser Val Phe Ala Arg Cys His Pro Leu 
225                 230                 235                 240 


Val Asp Pro Glu Pro Phe Val Ala Leu Cys Glu Lys Thr Leu Cys Glu 
                245                 250                 255     


Cys Ala Gly Gly Leu Glu Cys Ala Cys Pro Ala Leu Leu Glu Tyr Ala 
            260                 265                 270         


Arg Thr Cys Ala Gln Glu Gly Met Val Leu Tyr Gly Trp Thr Asp His 
        275                 280                 285             


Ser Ala Cys Ser Pro Val Cys Pro Ala Gly Met Glu Tyr Arg Gln Cys 
    290                 295                 300                 


Val Ser Pro Cys Ala Arg Thr Cys Gln Ser Leu His Ile Asn Glu Met 
305                 310                 315                 320 


Cys Gln Glu Arg Cys Val Asp Gly Cys Ser Cys Pro Glu Gly Gln Leu 
                325                 330                 335     


Leu Asp Glu Gly Leu Cys Val Glu Ser Thr Glu Cys Pro Cys Val His 
            340                 345                 350         


Ser Gly Lys Arg Tyr Pro Pro Gly Thr Ser Leu Ser Arg Asp Cys Asn 
        355                 360                 365             


Thr Cys Ile Cys Arg Asn Ser Gln Trp Ile Cys Ser Asn Glu Glu Cys 
    370                 375                 380                 


Pro Gly Glu Cys Leu Val Thr Gly Gln Ser His Phe Lys Ser Phe Asp 
385                 390                 395                 400 


Asn Arg Tyr Phe Thr Phe Ser Gly Ile Cys Gln Tyr Leu Leu Ala Arg 
                405                 410                 415     


Asp Cys Gln Asp His Ser Phe Ser Ile Val Ile Glu Thr Val Gln Cys 
            420                 425                 430         


Ala Asp Asp Arg Asp Ala Val Cys Thr Arg Ser Val Thr Val Arg Leu 
        435                 440                 445             


Pro Gly Leu His Asn Ser Leu Val Lys Leu Lys His Gly Ala Gly Val 
    450                 455                 460                 


Ala Met Asp Gly Gln Asp Ile Gln Leu Pro Leu Leu Lys Gly Asp Leu 
465                 470                 475                 480 


Arg Ile Gln His Thr Val Thr Ala Ser Val Arg Leu Ser Tyr Gly Glu 
                485                 490                 495     


Asp Leu Gln Met Asp Trp Asp Gly Arg Gly Arg Leu Leu Val Lys Leu 
            500                 505                 510         


Ser Pro Val Tyr Ala Gly Lys Thr Cys Gly Leu Cys Gly Asn Tyr Asn 
        515                 520                 525             


Gly Asn Gln Gly Asp Asp Phe Leu Thr Pro Ser Gly Leu Ala Glu Pro 
    530                 535                 540                 


Arg Val Glu Asp Phe Gly Asn Ala Trp Lys Leu His Gly Asp Cys Gln 
545                 550                 555                 560 


Asp Leu Gln Lys Gln His Ser Asp Pro Cys Ala Leu Asn Pro Arg Met 
                565                 570                 575     


Thr Arg Phe Ser Glu Glu Ala Cys Ala Val Leu Thr Ser Pro Thr Phe 
            580                 585                 590         


Glu Ala Cys His Arg Ala Val Ser Pro Leu Pro Tyr Leu Arg Asn Cys 
        595                 600                 605             


Arg Tyr Asp Val Cys Ser Cys Ser Asp Gly Arg Glu Cys Leu Cys Gly 
    610                 615                 620                 


Ala Leu Ala Ser Tyr Ala Ala Ala Cys Ala Gly Arg Gly Val Arg Val 
625                 630                 635                 640 


Ala Trp Arg Glu Pro Gly Arg Cys Glu Leu Asn Cys Pro Lys Gly Gln 
                645                 650                 655     


Val Tyr Leu Gln Cys Gly Thr Pro Cys Asn Leu Thr Cys Arg Ser Leu 
            660                 665                 670         


Ser Tyr Pro Asp Glu Glu Cys Asn Glu Ala Cys Leu Glu Gly Cys Phe 
        675                 680                 685             


Cys Pro Pro Gly Leu Tyr Met Asp Glu Arg Gly Asp Cys Val Pro Lys 
    690                 695                 700                 


Ala Gln Cys Pro Cys Tyr Tyr Asp Gly Glu Ile Phe Gln Pro Glu Asp 
705                 710                 715                 720 


Ile Phe Ser Asp His His Thr Met Cys Tyr Cys Glu Asp Gly Phe Met 
                725                 730                 735     


His Cys Thr Met Ser Gly Val Pro Gly Ser Leu Leu Pro Asp Ala Val 
            740                 745                 750         


Leu Ser Ser Pro Leu Ser His Arg Ser Lys Arg Ser Leu Ser Cys Arg 
        755                 760                 765             


Pro Pro Met Val Lys Leu Val Cys Pro Ala Asp Asn Leu Arg Ala Glu 
    770                 775                 780                 


Gly Leu Glu Cys Thr Lys Thr Cys Gln Asn Tyr Asp Leu Glu Cys Met 
785                 790                 795                 800 


Ser Met Gly Cys Val Ser Gly Cys Leu Cys Pro Pro Gly Met Val Arg 
                805                 810                 815     


His Glu Asn Arg Cys Val Ala Leu Glu Arg Cys Pro Cys Phe His Gln 
            820                 825                 830         


Gly Lys Glu Tyr Ala Pro Gly Glu Thr Val Lys Ile Gly Cys Asn Thr 
        835                 840                 845             


Cys Val Cys Arg Asp Arg Lys Trp Asn Cys Thr Asp His Val Cys Asp 
    850                 855                 860                 


Ala Thr Cys Ser Thr Ile Gly Met Ala His Tyr Leu Thr Phe Asp Gly 
865                 870                 875                 880 


Leu Lys Tyr Leu Phe Pro Gly Glu Cys Gln Tyr Val Leu Val Gln Asp 
                885                 890                 895     


Tyr Cys Gly Ser Asn Pro Gly Thr Phe Arg Ile Leu Val Gly Asn Lys 
            900                 905                 910         


Gly Cys Ser His Pro Ser Val Lys Cys Lys Lys Arg Val Thr Ile Leu 
        915                 920                 925             


Val Glu Gly Gly Glu Ile Glu Leu Phe Asp Gly Glu Val Asn Val Lys 
    930                 935                 940                 


Arg Pro Met Lys Asp Glu Thr His Phe Glu Val Val Glu Ser Gly Arg 
945                 950                 955                 960 


Tyr Ile Ile Leu Leu Leu Gly Lys Ala Leu Ser Val Val Trp Asp Arg 
                965                 970                 975     


His Leu Ser Ile Ser Val Val Leu Lys Gln Thr Tyr Gln Glu Lys Val 
            980                 985                 990         


Cys Gly Leu Cys Gly Asn Phe Asp  Gly Ile Gln Asn Asn  Asp Leu Thr 
        995                 1000                 1005             


Ser Ser  Asn Leu Gln Val Glu  Glu Asp Pro Val Asp  Phe Gly Asn 
    1010                 1015                 1020             


Ser Trp  Lys Val Ser Ser Gln  Cys Ala Asp Thr Arg  Lys Val Pro 
    1025                 1030                 1035             


Leu Asp  Ser Ser Pro Ala Thr  Cys His Asn Asn Ile  Met Lys Gln 
    1040                 1045                 1050             


Thr Met  Val Asp Ser Ser Cys  Arg Ile Leu Thr Ser  Asp Val Phe 
    1055                 1060                 1065             


Gln Asp  Cys Asn Lys Leu Val  Asp Pro Glu Pro Tyr  Leu Asp Val 
    1070                 1075                 1080             


Cys Ile  Tyr Asp Thr Cys Ser  Cys Glu Ser Ile Gly  Asp Cys Ala 
    1085                 1090                 1095             


Cys Phe  Cys Asp Thr Ile Ala  Ala Tyr Ala His Val  Cys Ala Gln 
    1100                 1105                 1110             


His Gly  Lys Val Val Thr Trp  Arg Thr Ala Thr Leu  Cys Pro Gln 
    1115                 1120                 1125             


Ser Cys  Glu Glu Arg Asn Leu  Arg Glu Asn Gly Tyr  Glu Cys Glu 
    1130                 1135                 1140             


Trp Arg  Tyr Asn Ser Cys Ala  Pro Ala Cys Gln Val  Thr Cys Gln 
    1145                 1150                 1155             


His Pro  Glu Pro Leu Ala Cys  Pro Val Gln Cys Val  Glu Gly Cys 
    1160                 1165                 1170             


His Ala  His Cys Pro Pro Gly  Lys Ile Leu Asp Glu  Leu Leu Gln 
    1175                 1180                 1185             


Thr Cys  Val Asp Pro Glu Asp  Cys Pro Val Cys Glu  Val Ala Gly 
    1190                 1195                 1200             


Arg Arg  Phe Ala Ser Gly Lys  Lys Val Thr Leu Asn  Pro Ser Asp 
    1205                 1210                 1215             


Pro Glu  His Cys Gln Ile Cys  His Cys Asp Val Val  Asn Leu Thr 
    1220                 1225                 1230             


Cys Glu  Ala Cys Gln Glu Pro  Gly Gly Leu Val Val  Pro Pro Thr 
    1235                 1240                 1245             


Asp Ala  Pro Val Ser Pro Thr  Thr Leu Tyr Val Glu  Asp Ile Ser 
    1250                 1255                 1260             


Glu Pro  Pro Leu His Asp Phe  Tyr Cys Ser Arg Leu  Leu Asp Leu 
    1265                 1270                 1275             


Val Phe  Leu Leu Asp Gly Ser  Ser Arg Leu Ser Glu  Ala Glu Phe 
    1280                 1285                 1290             


Glu Val  Leu Lys Ala Phe Val  Val Asp Met Met Glu  Arg Leu Arg 
    1295                 1300                 1305             


Ile Ser  Gln Lys Trp Val Arg  Val Ala Val Val Glu  Tyr His Asp 
    1310                 1315                 1320             


Gly Ser  His Ala Tyr Ile Gly  Leu Lys Asp Arg Lys  Arg Pro Ser 
    1325                 1330                 1335             


Glu Leu  Arg Arg Ile Ala Ser  Gln Val Lys Tyr Ala  Gly Ser Gln 
    1340                 1345                 1350             


Val Ala  Ser Thr Ser Glu Val  Leu Lys Tyr Thr Leu  Phe Gln Ile 
    1355                 1360                 1365             


Phe Ser  Lys Ile Asp Arg Pro  Glu Ala Ser Arg Ile  Ala Leu Leu 
    1370                 1375                 1380             


Leu Met  Ala Ser Gln Glu Pro  Gln Arg Met Ser Arg  Asn Phe Val 
    1385                 1390                 1395             


Arg Tyr  Val Gln Gly Leu Lys  Lys Lys Lys Val Ile  Val Ile Pro 
    1400                 1405                 1410             


Val Gly  Ile Gly Pro His Ala  Asn Leu Lys Gln Ile  Arg Leu Ile 
    1415                 1420                 1425             


Glu Lys  Gln Ala Pro Glu Asn  Lys Ala Phe Val Leu  Ser Ser Val 
    1430                 1435                 1440             


Asp Glu  Leu Glu Gln Gln Arg  Asp Glu Ile Val Ser  Tyr Leu Cys 
    1445                 1450                 1455             


Asp Leu  Ala Pro Glu Ala Pro  Pro Pro Thr Leu Pro  Pro His Met 
    1460                 1465                 1470             


Ala Gln  Val Thr Val Gly Pro  Gly 
    1475                 1480     


<210>  14
<211>  1857
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  sequence

<400>  14

Ala Glu Gly Thr Arg Gly Arg Ser Ser Thr Ala Arg Cys Ser Leu Phe 
1               5                   10                  15      


Gly Ser Asp Phe Val Asn Thr Phe Asp Gly Ser Met Tyr Ser Phe Ala 
            20                  25                  30          


Gly Tyr Cys Ser Tyr Leu Leu Ala Gly Gly Cys Gln Lys Arg Ser Phe 
        35                  40                  45              


Ser Ile Ile Gly Asp Phe Gln Asn Gly Lys Arg Val Ser Leu Ser Val 
    50                  55                  60                  


Tyr Leu Gly Glu Phe Phe Asp Ile His Leu Phe Val Asn Gly Thr Val 
65                  70                  75                  80  


Thr Gln Gly Asp Gln Arg Val Ser Met Pro Tyr Ala Ser Lys Gly Leu 
                85                  90                  95      


Tyr Leu Glu Thr Glu Ala Gly Tyr Tyr Lys Leu Ser Gly Glu Ala Tyr 
            100                 105                 110         


Gly Phe Val Ala Arg Ile Asp Gly Ser Gly Asn Phe Gln Val Leu Leu 
        115                 120                 125             


Ser Asp Arg Tyr Phe Asn Lys Thr Cys Gly Leu Cys Gly Asn Phe Asn 
    130                 135                 140                 


Ile Phe Ala Glu Asp Asp Phe Met Thr Gln Glu Gly Thr Leu Thr Ser 
145                 150                 155                 160 


Asp Pro Tyr Asp Phe Ala Asn Ser Trp Ala Leu Ser Ser Gly Glu Gln 
                165                 170                 175     


Trp Cys Glu Arg Ala Ser Pro Pro Ser Ser Ser Cys Asn Ile Ser Ser 
            180                 185                 190         


Gly Glu Met Gln Lys Gly Leu Trp Glu Gln Cys Gln Leu Leu Lys Ser 
        195                 200                 205             


Thr Ser Val Phe Ala Arg Cys His Pro Leu Val Asp Pro Glu Pro Phe 
    210                 215                 220                 


Val Ala Leu Cys Glu Lys Thr Leu Cys Glu Cys Ala Gly Gly Leu Glu 
225                 230                 235                 240 


Cys Ala Cys Pro Ala Leu Leu Glu Tyr Ala Arg Thr Cys Ala Gln Glu 
                245                 250                 255     


Gly Met Val Leu Tyr Gly Trp Thr Asp His Ser Ala Cys Ser Pro Val 
            260                 265                 270         


Cys Pro Ala Gly Met Glu Tyr Arg Gln Cys Val Ser Pro Cys Ala Arg 
        275                 280                 285             


Thr Cys Gln Ser Leu His Ile Asn Glu Met Cys Gln Glu Arg Cys Val 
    290                 295                 300                 


Asp Gly Cys Ser Cys Pro Glu Gly Gln Leu Leu Asp Glu Gly Leu Cys 
305                 310                 315                 320 


Val Glu Ser Thr Glu Cys Pro Cys Val His Ser Gly Lys Arg Tyr Pro 
                325                 330                 335     


Pro Gly Thr Ser Leu Ser Arg Asp Cys Asn Thr Cys Ile Cys Arg Asn 
            340                 345                 350         


Ser Gln Trp Ile Cys Ser Asn Glu Glu Cys Pro Gly Glu Cys Leu Val 
        355                 360                 365             


Thr Gly Gln Ser His Phe Lys Ser Phe Asp Asn Arg Tyr Phe Thr Phe 
    370                 375                 380                 


Ser Gly Ile Cys Gln Tyr Leu Leu Ala Arg Asp Cys Gln Asp His Ser 
385                 390                 395                 400 


Phe Ser Ile Val Ile Glu Thr Val Gln Cys Ala Asp Asp Arg Asp Ala 
                405                 410                 415     


Val Cys Thr Arg Ser Val Thr Val Arg Leu Pro Gly Leu His Asn Ser 
            420                 425                 430         


Leu Val Lys Leu Lys His Gly Ala Gly Val Ala Met Asp Gly Gln Asp 
        435                 440                 445             


Ile Gln Leu Pro Leu Leu Lys Gly Asp Leu Arg Ile Gln His Thr Val 
    450                 455                 460                 


Thr Ala Ser Val Arg Leu Ser Tyr Gly Glu Asp Leu Gln Met Asp Trp 
465                 470                 475                 480 


Asp Gly Arg Gly Arg Leu Leu Val Lys Leu Ser Pro Val Tyr Ala Gly 
                485                 490                 495     


Lys Thr Cys Gly Leu Cys Gly Asn Tyr Asn Gly Asn Gln Gly Asp Asp 
            500                 505                 510         


Phe Leu Thr Pro Ser Gly Leu Ala Glu Pro Arg Val Glu Asp Phe Gly 
        515                 520                 525             


Asn Ala Trp Lys Leu His Gly Asp Cys Gln Asp Leu Gln Lys Gln His 
    530                 535                 540                 


Ser Asp Pro Cys Ala Leu Asn Pro Arg Met Thr Arg Phe Ser Glu Glu 
545                 550                 555                 560 


Ala Cys Ala Val Leu Thr Ser Pro Thr Phe Glu Ala Cys His Arg Ala 
                565                 570                 575     


Val Ser Pro Leu Pro Tyr Leu Arg Asn Cys Arg Tyr Asp Val Cys Ser 
            580                 585                 590         


Cys Ser Asp Gly Arg Glu Cys Leu Cys Gly Ala Leu Ala Ser Tyr Ala 
        595                 600                 605             


Ala Ala Cys Ala Gly Arg Gly Val Arg Val Ala Trp Arg Glu Pro Gly 
    610                 615                 620                 


Arg Cys Glu Leu Asn Cys Pro Lys Gly Gln Val Tyr Leu Gln Cys Gly 
625                 630                 635                 640 


Thr Pro Cys Asn Leu Thr Cys Arg Ser Leu Ser Tyr Pro Asp Glu Glu 
                645                 650                 655     


Cys Asn Glu Ala Cys Leu Glu Gly Cys Phe Cys Pro Pro Gly Leu Tyr 
            660                 665                 670         


Met Asp Glu Arg Gly Asp Cys Val Pro Lys Ala Gln Cys Pro Cys Tyr 
        675                 680                 685             


Tyr Asp Gly Glu Ile Phe Gln Pro Glu Asp Ile Phe Ser Asp His His 
    690                 695                 700                 


Thr Met Cys Tyr Cys Glu Asp Gly Phe Met His Cys Thr Met Ser Gly 
705                 710                 715                 720 


Val Pro Gly Ser Leu Leu Pro Asp Ala Val Leu Ser Ser Pro Leu Ser 
                725                 730                 735     


His Arg Ser Lys Arg Ser Leu Ser Cys Arg Pro Pro Met Val Lys Leu 
            740                 745                 750         


Val Cys Pro Ala Asp Asn Leu Arg Ala Glu Gly Leu Glu Cys Thr Lys 
        755                 760                 765             


Thr Cys Gln Asn Tyr Asp Leu Glu Cys Met Ser Met Gly Cys Val Ser 
    770                 775                 780                 


Gly Cys Leu Cys Pro Pro Gly Met Val Arg His Glu Asn Arg Cys Val 
785                 790                 795                 800 


Ala Leu Glu Arg Cys Pro Cys Phe His Gln Gly Lys Glu Tyr Ala Pro 
                805                 810                 815     


Gly Glu Thr Val Lys Ile Gly Cys Asn Thr Cys Val Cys Arg Asp Arg 
            820                 825                 830         


Lys Trp Asn Cys Thr Asp His Val Cys Asp Ala Thr Cys Ser Thr Ile 
        835                 840                 845             


Gly Met Ala His Tyr Leu Thr Phe Asp Gly Leu Lys Tyr Leu Phe Pro 
    850                 855                 860                 


Gly Glu Cys Gln Tyr Val Leu Val Gln Asp Tyr Cys Gly Ser Asn Pro 
865                 870                 875                 880 


Gly Thr Phe Arg Ile Leu Val Gly Asn Lys Gly Cys Ser His Pro Ser 
                885                 890                 895     


Val Lys Cys Lys Lys Arg Val Thr Ile Leu Val Glu Gly Gly Glu Ile 
            900                 905                 910         


Glu Leu Phe Asp Gly Glu Val Asn Val Lys Arg Pro Met Lys Asp Glu 
        915                 920                 925             


Thr His Phe Glu Val Val Glu Ser Gly Arg Tyr Ile Ile Leu Leu Leu 
    930                 935                 940                 


Gly Lys Ala Leu Ser Val Val Trp Asp Arg His Leu Ser Ile Ser Val 
945                 950                 955                 960 


Val Leu Lys Gln Thr Tyr Gln Glu Lys Val Cys Gly Leu Cys Gly Asn 
                965                 970                 975     


Phe Asp Gly Ile Gln Asn Asn Asp Leu Thr Ser Ser Asn Leu Gln Val 
            980                 985                 990         


Glu Glu Asp Pro Val Asp Phe Gly  Asn Ser Trp Lys Val  Ser Ser Gln 
        995                 1000                 1005             


Cys Ala  Asp Thr Arg Lys Val  Pro Leu Asp Ser Ser  Pro Ala Thr 
    1010                 1015                 1020             


Cys His  Asn Asn Ile Met Lys  Gln Thr Met Val Asp  Ser Ser Cys 
    1025                 1030                 1035             


Arg Ile  Leu Thr Ser Asp Val  Phe Gln Asp Cys Asn  Lys Leu Val 
    1040                 1045                 1050             


Asp Pro  Glu Pro Tyr Leu Asp  Val Cys Ile Tyr Asp  Thr Cys Ser 
    1055                 1060                 1065             


Cys Glu  Ser Ile Gly Asp Cys  Ala Cys Phe Cys Asp  Thr Ile Ala 
    1070                 1075                 1080             


Ala Tyr  Ala His Val Cys Ala  Gln His Gly Lys Val  Val Thr Trp 
    1085                 1090                 1095             


Arg Thr  Ala Thr Leu Cys Pro  Gln Ser Cys Glu Glu  Arg Asn Leu 
    1100                 1105                 1110             


Arg Glu  Asn Gly Tyr Glu Cys  Glu Trp Arg Tyr Asn  Ser Cys Ala 
    1115                 1120                 1125             


Pro Ala  Cys Gln Val Thr Cys  Gln His Pro Glu Pro  Leu Ala Cys 
    1130                 1135                 1140             


Pro Val  Gln Cys Val Glu Gly  Cys His Ala His Cys  Pro Pro Gly 
    1145                 1150                 1155             


Lys Ile  Leu Asp Glu Leu Leu  Gln Thr Cys Val Asp  Pro Glu Asp 
    1160                 1165                 1170             


Cys Pro  Val Cys Glu Val Ala  Gly Arg Arg Phe Ala  Ser Gly Lys 
    1175                 1180                 1185             


Lys Val  Thr Leu Asn Pro Ser  Asp Pro Glu His Cys  Gln Ile Cys 
    1190                 1195                 1200             


His Cys  Asp Val Val Asn Leu  Thr Cys Glu Ala Cys  Gln Glu Pro 
    1205                 1210                 1215             


Gly Gly  Leu Val Val Pro Pro  Thr Asp Ala Pro Val  Ser Pro Thr 
    1220                 1225                 1230             


Thr Leu  Tyr Val Glu Asp Ile  Ser Glu Pro Pro Leu  His Asp Phe 
    1235                 1240                 1245             


Tyr Cys  Ser Arg Leu Leu Asp  Leu Val Phe Leu Leu  Asp Gly Ser 
    1250                 1255                 1260             


Ser Arg  Leu Ser Glu Ala Glu  Phe Glu Val Leu Lys  Ala Phe Val 
    1265                 1270                 1275             


Val Asp  Met Met Glu Arg Leu  Arg Ile Ser Gln Lys  Trp Val Arg 
    1280                 1285                 1290             


Val Ala  Val Val Glu Tyr His  Asp Gly Ser His Ala  Tyr Ile Gly 
    1295                 1300                 1305             


Leu Lys  Asp Arg Lys Arg Pro  Ser Glu Leu Arg Arg  Ile Ala Ser 
    1310                 1315                 1320             


Gln Val  Lys Tyr Ala Gly Ser  Gln Val Ala Ser Thr  Ser Glu Val 
    1325                 1330                 1335             


Leu Lys  Tyr Thr Leu Phe Gln  Ile Phe Ser Lys Ile  Asp Arg Pro 
    1340                 1345                 1350             


Glu Ala  Ser Arg Ile Ala Leu  Leu Leu Met Ala Ser  Gln Glu Pro 
    1355                 1360                 1365             


Gln Arg  Met Ser Arg Asn Phe  Val Arg Tyr Val Gln  Gly Leu Lys 
    1370                 1375                 1380             


Lys Lys  Lys Val Ile Val Ile  Pro Val Gly Ile Gly  Pro His Ala 
    1385                 1390                 1395             


Asn Leu  Lys Gln Ile Arg Leu  Ile Glu Lys Gln Ala  Pro Glu Asn 
    1400                 1405                 1410             


Lys Ala  Phe Val Leu Ser Ser  Val Asp Glu Leu Glu  Gln Gln Arg 
    1415                 1420                 1425             


Asp Glu  Ile Val Ser Tyr Leu  Cys Asp Leu Ala Pro  Glu Ala Pro 
    1430                 1435                 1440             


Pro Pro  Thr Leu Pro Pro His  Met Ala Gln Val Thr  Val Gly Pro 
    1445                 1450                 1455             


Gly Leu  Leu Gly Val Ser Thr  Leu Gly Pro Lys Arg  Asn Ser Met 
    1460                 1465                 1470             


Val Leu  Asp Val Ala Phe Val  Leu Glu Gly Ser Asp  Lys Ile Gly 
    1475                 1480                 1485             


Glu Ala  Asp Phe Asn Arg Ser  Lys Glu Phe Met Glu  Glu Val Ile 
    1490                 1495                 1500             


Gln Arg  Met Asp Val Gly Gln  Asp Ser Ile His Val  Thr Val Leu 
    1505                 1510                 1515             


Gln Tyr  Ser Tyr Met Val Thr  Val Glu Tyr Pro Phe  Ser Glu Ala 
    1520                 1525                 1530             


Gln Ser  Lys Gly Asp Ile Leu  Gln Arg Val Arg Glu  Ile Arg Tyr 
    1535                 1540                 1545             


Gln Gly  Gly Asn Arg Thr Asn  Thr Gly Leu Ala Leu  Arg Tyr Leu 
    1550                 1555                 1560             


Ser Asp  His Ser Phe Leu Val  Ser Gln Gly Asp Arg  Glu Gln Ala 
    1565                 1570                 1575             


Pro Asn  Leu Val Tyr Met Val  Thr Gly Asn Pro Ala  Ser Asp Glu 
    1580                 1585                 1590             


Ile Lys  Arg Leu Pro Gly Asp  Ile Gln Val Val Pro  Ile Gly Val 
    1595                 1600                 1605             


Gly Pro  Asn Ala Asn Val Gln  Glu Leu Glu Arg Ile  Gly Trp Pro 
    1610                 1615                 1620             


Asn Ala  Pro Ile Leu Ile Gln  Asp Phe Glu Thr Leu  Pro Arg Glu 
    1625                 1630                 1635             


Ala Pro  Asp Leu Val Leu Gln  Arg Cys Cys Ser Gly  Glu Gly Leu 
    1640                 1645                 1650             


Gln Ile  Pro Thr Leu Ser Pro  Ala Pro Asp Cys Ser  Gln Pro Leu 
    1655                 1660                 1665             


Asp Val  Ile Leu Leu Leu Asp  Gly Ser Ser Ser Phe  Pro Ala Ser 
    1670                 1675                 1680             


Tyr Phe  Asp Glu Met Lys Ser  Phe Ala Lys Ala Phe  Ile Ser Lys 
    1685                 1690                 1695             


Ala Asn  Ile Gly Pro Arg Leu  Thr Gln Val Ser Val  Leu Gln Tyr 
    1700                 1705                 1710             


Gly Ser  Ile Thr Thr Ile Asp  Val Pro Trp Asn Val  Val Pro Glu 
    1715                 1720                 1725             


Lys Ala  His Leu Leu Ser Leu  Val Asp Val Met Gln  Arg Glu Gly 
    1730                 1735                 1740             


Gly Pro  Ser Gln Ile Gly Asp  Ala Leu Gly Phe Ala  Val Arg Tyr 
    1745                 1750                 1755             


Leu Thr  Ser Glu Met His Gly  Ala Arg Pro Gly Ala  Ser Lys Ala 
    1760                 1765                 1770             


Val Val  Ile Leu Val Thr Asp  Val Ser Val Asp Ser  Val Asp Ala 
    1775                 1780                 1785             


Ala Ala  Asp Ala Ala Arg Ser  Asn Arg Val Thr Val  Phe Pro Ile 
    1790                 1795                 1800             


Gly Ile  Gly Asp Arg Tyr Asp  Ala Ala Gln Leu Arg  Ile Leu Ala 
    1805                 1810                 1815             


Gly Pro  Ala Gly Asp Ser Asn  Val Val Lys Leu Gln  Arg Ile Glu 
    1820                 1825                 1830             


Asp Leu  Pro Thr Met Val Thr  Leu Gly Asn Ser Phe  Leu His Lys 
    1835                 1840                 1845             


Leu Cys  Ser Gly Phe Val Arg  Ile Cys 
    1850                 1855         


<210>  15
<211>  1879
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  sequence

<400>  15

Met Ile Pro Ala Arg Phe Ala Gly Val Leu Leu Ala Leu Ala Leu Ile 
1               5                   10                  15      


Leu Pro Gly Thr Leu Cys Ala Glu Gly Thr Arg Gly Arg Ser Ser Thr 
            20                  25                  30          


Ala Arg Cys Ser Leu Phe Gly Ser Asp Phe Val Asn Thr Phe Asp Gly 
        35                  40                  45              


Ser Met Tyr Ser Phe Ala Gly Tyr Cys Ser Tyr Leu Leu Ala Gly Gly 
    50                  55                  60                  


Cys Gln Lys Arg Ser Phe Ser Ile Ile Gly Asp Phe Gln Asn Gly Lys 
65                  70                  75                  80  


Arg Val Ser Leu Ser Val Tyr Leu Gly Glu Phe Phe Asp Ile His Leu 
                85                  90                  95      


Phe Val Asn Gly Thr Val Thr Gln Gly Asp Gln Arg Val Ser Met Pro 
            100                 105                 110         


Tyr Ala Ser Lys Gly Leu Tyr Leu Glu Thr Glu Ala Gly Tyr Tyr Lys 
        115                 120                 125             


Leu Ser Gly Glu Ala Tyr Gly Phe Val Ala Arg Ile Asp Gly Ser Gly 
    130                 135                 140                 


Asn Phe Gln Val Leu Leu Ser Asp Arg Tyr Phe Asn Lys Thr Cys Gly 
145                 150                 155                 160 


Leu Cys Gly Asn Phe Asn Ile Phe Ala Glu Asp Asp Phe Met Thr Gln 
                165                 170                 175     


Glu Gly Thr Leu Thr Ser Asp Pro Tyr Asp Phe Ala Asn Ser Trp Ala 
            180                 185                 190         


Leu Ser Ser Gly Glu Gln Trp Cys Glu Arg Ala Ser Pro Pro Ser Ser 
        195                 200                 205             


Ser Cys Asn Ile Ser Ser Gly Glu Met Gln Lys Gly Leu Trp Glu Gln 
    210                 215                 220                 


Cys Gln Leu Leu Lys Ser Thr Ser Val Phe Ala Arg Cys His Pro Leu 
225                 230                 235                 240 


Val Asp Pro Glu Pro Phe Val Ala Leu Cys Glu Lys Thr Leu Cys Glu 
                245                 250                 255     


Cys Ala Gly Gly Leu Glu Cys Ala Cys Pro Ala Leu Leu Glu Tyr Ala 
            260                 265                 270         


Arg Thr Cys Ala Gln Glu Gly Met Val Leu Tyr Gly Trp Thr Asp His 
        275                 280                 285             


Ser Ala Cys Ser Pro Val Cys Pro Ala Gly Met Glu Tyr Arg Gln Cys 
    290                 295                 300                 


Val Ser Pro Cys Ala Arg Thr Cys Gln Ser Leu His Ile Asn Glu Met 
305                 310                 315                 320 


Cys Gln Glu Arg Cys Val Asp Gly Cys Ser Cys Pro Glu Gly Gln Leu 
                325                 330                 335     


Leu Asp Glu Gly Leu Cys Val Glu Ser Thr Glu Cys Pro Cys Val His 
            340                 345                 350         


Ser Gly Lys Arg Tyr Pro Pro Gly Thr Ser Leu Ser Arg Asp Cys Asn 
        355                 360                 365             


Thr Cys Ile Cys Arg Asn Ser Gln Trp Ile Cys Ser Asn Glu Glu Cys 
    370                 375                 380                 


Pro Gly Glu Cys Leu Val Thr Gly Gln Ser His Phe Lys Ser Phe Asp 
385                 390                 395                 400 


Asn Arg Tyr Phe Thr Phe Ser Gly Ile Cys Gln Tyr Leu Leu Ala Arg 
                405                 410                 415     


Asp Cys Gln Asp His Ser Phe Ser Ile Val Ile Glu Thr Val Gln Cys 
            420                 425                 430         


Ala Asp Asp Arg Asp Ala Val Cys Thr Arg Ser Val Thr Val Arg Leu 
        435                 440                 445             


Pro Gly Leu His Asn Ser Leu Val Lys Leu Lys His Gly Ala Gly Val 
    450                 455                 460                 


Ala Met Asp Gly Gln Asp Ile Gln Leu Pro Leu Leu Lys Gly Asp Leu 
465                 470                 475                 480 


Arg Ile Gln His Thr Val Thr Ala Ser Val Arg Leu Ser Tyr Gly Glu 
                485                 490                 495     


Asp Leu Gln Met Asp Trp Asp Gly Arg Gly Arg Leu Leu Val Lys Leu 
            500                 505                 510         


Ser Pro Val Tyr Ala Gly Lys Thr Cys Gly Leu Cys Gly Asn Tyr Asn 
        515                 520                 525             


Gly Asn Gln Gly Asp Asp Phe Leu Thr Pro Ser Gly Leu Ala Glu Pro 
    530                 535                 540                 


Arg Val Glu Asp Phe Gly Asn Ala Trp Lys Leu His Gly Asp Cys Gln 
545                 550                 555                 560 


Asp Leu Gln Lys Gln His Ser Asp Pro Cys Ala Leu Asn Pro Arg Met 
                565                 570                 575     


Thr Arg Phe Ser Glu Glu Ala Cys Ala Val Leu Thr Ser Pro Thr Phe 
            580                 585                 590         


Glu Ala Cys His Arg Ala Val Ser Pro Leu Pro Tyr Leu Arg Asn Cys 
        595                 600                 605             


Arg Tyr Asp Val Cys Ser Cys Ser Asp Gly Arg Glu Cys Leu Cys Gly 
    610                 615                 620                 


Ala Leu Ala Ser Tyr Ala Ala Ala Cys Ala Gly Arg Gly Val Arg Val 
625                 630                 635                 640 


Ala Trp Arg Glu Pro Gly Arg Cys Glu Leu Asn Cys Pro Lys Gly Gln 
                645                 650                 655     


Val Tyr Leu Gln Cys Gly Thr Pro Cys Asn Leu Thr Cys Arg Ser Leu 
            660                 665                 670         


Ser Tyr Pro Asp Glu Glu Cys Asn Glu Ala Cys Leu Glu Gly Cys Phe 
        675                 680                 685             


Cys Pro Pro Gly Leu Tyr Met Asp Glu Arg Gly Asp Cys Val Pro Lys 
    690                 695                 700                 


Ala Gln Cys Pro Cys Tyr Tyr Asp Gly Glu Ile Phe Gln Pro Glu Asp 
705                 710                 715                 720 


Ile Phe Ser Asp His His Thr Met Cys Tyr Cys Glu Asp Gly Phe Met 
                725                 730                 735     


His Cys Thr Met Ser Gly Val Pro Gly Ser Leu Leu Pro Asp Ala Val 
            740                 745                 750         


Leu Ser Ser Pro Leu Ser His Arg Ser Lys Arg Ser Leu Ser Cys Arg 
        755                 760                 765             


Pro Pro Met Val Lys Leu Val Cys Pro Ala Asp Asn Leu Arg Ala Glu 
    770                 775                 780                 


Gly Leu Glu Cys Thr Lys Thr Cys Gln Asn Tyr Asp Leu Glu Cys Met 
785                 790                 795                 800 


Ser Met Gly Cys Val Ser Gly Cys Leu Cys Pro Pro Gly Met Val Arg 
                805                 810                 815     


His Glu Asn Arg Cys Val Ala Leu Glu Arg Cys Pro Cys Phe His Gln 
            820                 825                 830         


Gly Lys Glu Tyr Ala Pro Gly Glu Thr Val Lys Ile Gly Cys Asn Thr 
        835                 840                 845             


Cys Val Cys Arg Asp Arg Lys Trp Asn Cys Thr Asp His Val Cys Asp 
    850                 855                 860                 


Ala Thr Cys Ser Thr Ile Gly Met Ala His Tyr Leu Thr Phe Asp Gly 
865                 870                 875                 880 


Leu Lys Tyr Leu Phe Pro Gly Glu Cys Gln Tyr Val Leu Val Gln Asp 
                885                 890                 895     


Tyr Cys Gly Ser Asn Pro Gly Thr Phe Arg Ile Leu Val Gly Asn Lys 
            900                 905                 910         


Gly Cys Ser His Pro Ser Val Lys Cys Lys Lys Arg Val Thr Ile Leu 
        915                 920                 925             


Val Glu Gly Gly Glu Ile Glu Leu Phe Asp Gly Glu Val Asn Val Lys 
    930                 935                 940                 


Arg Pro Met Lys Asp Glu Thr His Phe Glu Val Val Glu Ser Gly Arg 
945                 950                 955                 960 


Tyr Ile Ile Leu Leu Leu Gly Lys Ala Leu Ser Val Val Trp Asp Arg 
                965                 970                 975     


His Leu Ser Ile Ser Val Val Leu Lys Gln Thr Tyr Gln Glu Lys Val 
            980                 985                 990         


Cys Gly Leu Cys Gly Asn Phe Asp  Gly Ile Gln Asn Asn  Asp Leu Thr 
        995                 1000                 1005             


Ser Ser  Asn Leu Gln Val Glu  Glu Asp Pro Val Asp  Phe Gly Asn 
    1010                 1015                 1020             


Ser Trp  Lys Val Ser Ser Gln  Cys Ala Asp Thr Arg  Lys Val Pro 
    1025                 1030                 1035             


Leu Asp  Ser Ser Pro Ala Thr  Cys His Asn Asn Ile  Met Lys Gln 
    1040                 1045                 1050             


Thr Met  Val Asp Ser Ser Cys  Arg Ile Leu Thr Ser  Asp Val Phe 
    1055                 1060                 1065             


Gln Asp  Cys Asn Lys Leu Val  Asp Pro Glu Pro Tyr  Leu Asp Val 
    1070                 1075                 1080             


Cys Ile  Tyr Asp Thr Cys Ser  Cys Glu Ser Ile Gly  Asp Cys Ala 
    1085                 1090                 1095             


Cys Phe  Cys Asp Thr Ile Ala  Ala Tyr Ala His Val  Cys Ala Gln 
    1100                 1105                 1110             


His Gly  Lys Val Val Thr Trp  Arg Thr Ala Thr Leu  Cys Pro Gln 
    1115                 1120                 1125             


Ser Cys  Glu Glu Arg Asn Leu  Arg Glu Asn Gly Tyr  Glu Cys Glu 
    1130                 1135                 1140             


Trp Arg  Tyr Asn Ser Cys Ala  Pro Ala Cys Gln Val  Thr Cys Gln 
    1145                 1150                 1155             


His Pro  Glu Pro Leu Ala Cys  Pro Val Gln Cys Val  Glu Gly Cys 
    1160                 1165                 1170             


His Ala  His Cys Pro Pro Gly  Lys Ile Leu Asp Glu  Leu Leu Gln 
    1175                 1180                 1185             


Thr Cys  Val Asp Pro Glu Asp  Cys Pro Val Cys Glu  Val Ala Gly 
    1190                 1195                 1200             


Arg Arg  Phe Ala Ser Gly Lys  Lys Val Thr Leu Asn  Pro Ser Asp 
    1205                 1210                 1215             


Pro Glu  His Cys Gln Ile Cys  His Cys Asp Val Val  Asn Leu Thr 
    1220                 1225                 1230             


Cys Glu  Ala Cys Gln Glu Pro  Gly Gly Leu Val Val  Pro Pro Thr 
    1235                 1240                 1245             


Asp Ala  Pro Val Ser Pro Thr  Thr Leu Tyr Val Glu  Asp Ile Ser 
    1250                 1255                 1260             


Glu Pro  Pro Leu His Asp Phe  Tyr Cys Ser Arg Leu  Leu Asp Leu 
    1265                 1270                 1275             


Val Phe  Leu Leu Asp Gly Ser  Ser Arg Leu Ser Glu  Ala Glu Phe 
    1280                 1285                 1290             


Glu Val  Leu Lys Ala Phe Val  Val Asp Met Met Glu  Arg Leu Arg 
    1295                 1300                 1305             


Ile Ser  Gln Lys Trp Val Arg  Val Ala Val Val Glu  Tyr His Asp 
    1310                 1315                 1320             


Gly Ser  His Ala Tyr Ile Gly  Leu Lys Asp Arg Lys  Arg Pro Ser 
    1325                 1330                 1335             


Glu Leu  Arg Arg Ile Ala Ser  Gln Val Lys Tyr Ala  Gly Ser Gln 
    1340                 1345                 1350             


Val Ala  Ser Thr Ser Glu Val  Leu Lys Tyr Thr Leu  Phe Gln Ile 
    1355                 1360                 1365             


Phe Ser  Lys Ile Asp Arg Pro  Glu Ala Ser Arg Ile  Ala Leu Leu 
    1370                 1375                 1380             


Leu Met  Ala Ser Gln Glu Pro  Gln Arg Met Ser Arg  Asn Phe Val 
    1385                 1390                 1395             


Arg Tyr  Val Gln Gly Leu Lys  Lys Lys Lys Val Ile  Val Ile Pro 
    1400                 1405                 1410             


Val Gly  Ile Gly Pro His Ala  Asn Leu Lys Gln Ile  Arg Leu Ile 
    1415                 1420                 1425             


Glu Lys  Gln Ala Pro Glu Asn  Lys Ala Phe Val Leu  Ser Ser Val 
    1430                 1435                 1440             


Asp Glu  Leu Glu Gln Gln Arg  Asp Glu Ile Val Ser  Tyr Leu Cys 
    1445                 1450                 1455             


Asp Leu  Ala Pro Glu Ala Pro  Pro Pro Thr Leu Pro  Pro His Met 
    1460                 1465                 1470             


Ala Gln  Val Thr Val Gly Pro  Gly Leu Leu Gly Val  Ser Thr Leu 
    1475                 1480                 1485             


Gly Pro  Lys Arg Asn Ser Met  Val Leu Asp Val Ala  Phe Val Leu 
    1490                 1495                 1500             


Glu Gly  Ser Asp Lys Ile Gly  Glu Ala Asp Phe Asn  Arg Ser Lys 
    1505                 1510                 1515             


Glu Phe  Met Glu Glu Val Ile  Gln Arg Met Asp Val  Gly Gln Asp 
    1520                 1525                 1530             


Ser Ile  His Val Thr Val Leu  Gln Tyr Ser Tyr Met  Val Thr Val 
    1535                 1540                 1545             


Glu Tyr  Pro Phe Ser Glu Ala  Gln Ser Lys Gly Asp  Ile Leu Gln 
    1550                 1555                 1560             


Arg Val  Arg Glu Ile Arg Tyr  Gln Gly Gly Asn Arg  Thr Asn Thr 
    1565                 1570                 1575             


Gly Leu  Ala Leu Arg Tyr Leu  Ser Asp His Ser Phe  Leu Val Ser 
    1580                 1585                 1590             


Gln Gly  Asp Arg Glu Gln Ala  Pro Asn Leu Val Tyr  Met Val Thr 
    1595                 1600                 1605             


Gly Asn  Pro Ala Ser Asp Glu  Ile Lys Arg Leu Pro  Gly Asp Ile 
    1610                 1615                 1620             


Gln Val  Val Pro Ile Gly Val  Gly Pro Asn Ala Asn  Val Gln Glu 
    1625                 1630                 1635             


Leu Glu  Arg Ile Gly Trp Pro  Asn Ala Pro Ile Leu  Ile Gln Asp 
    1640                 1645                 1650             


Phe Glu  Thr Leu Pro Arg Glu  Ala Pro Asp Leu Val  Leu Gln Arg 
    1655                 1660                 1665             


Cys Cys  Ser Gly Glu Gly Leu  Gln Ile Pro Thr Leu  Ser Pro Ala 
    1670                 1675                 1680             


Pro Asp  Cys Ser Gln Pro Leu  Asp Val Ile Leu Leu  Leu Asp Gly 
    1685                 1690                 1695             


Ser Ser  Ser Phe Pro Ala Ser  Tyr Phe Asp Glu Met  Lys Ser Phe 
    1700                 1705                 1710             


Ala Lys  Ala Phe Ile Ser Lys  Ala Asn Ile Gly Pro  Arg Leu Thr 
    1715                 1720                 1725             


Gln Val  Ser Val Leu Gln Tyr  Gly Ser Ile Thr Thr  Ile Asp Val 
    1730                 1735                 1740             


Pro Trp  Asn Val Val Pro Glu  Lys Ala His Leu Leu  Ser Leu Val 
    1745                 1750                 1755             


Asp Val  Met Gln Arg Glu Gly  Gly Pro Ser Gln Ile  Gly Asp Ala 
    1760                 1765                 1770             


Leu Gly  Phe Ala Val Arg Tyr  Leu Thr Ser Glu Met  His Gly Ala 
    1775                 1780                 1785             


Arg Pro  Gly Ala Ser Lys Ala  Val Val Ile Leu Val  Thr Asp Val 
    1790                 1795                 1800             


Ser Val  Asp Ser Val Asp Ala  Ala Ala Asp Ala Ala  Arg Ser Asn 
    1805                 1810                 1815             


Arg Val  Thr Val Phe Pro Ile  Gly Ile Gly Asp Arg  Tyr Asp Ala 
    1820                 1825                 1830             


Ala Gln  Leu Arg Ile Leu Ala  Gly Pro Ala Gly Asp  Ser Asn Val 
    1835                 1840                 1845             


Val Lys  Leu Gln Arg Ile Glu  Asp Leu Pro Thr Met  Val Thr Leu 
    1850                 1855                 1860             


Gly Asn  Ser Phe Leu His Lys  Leu Cys Ser Gly Phe  Val Arg Ile 
    1865                 1870                 1875             


Cys 
    


<210>  16
<211>  227
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  sequence

<400>  16

Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly 
1               5                   10                  15      


Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
            20                  25                  30          


Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 
        35                  40                  45              


Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
    50                  55                  60                  


His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr 
65                  70                  75                  80  


Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 
                85                  90                  95      


Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile 
            100                 105                 110         


Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 
        115                 120                 125             


Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser 
    130                 135                 140                 


Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
145                 150                 155                 160 


Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
                165                 170                 175     


Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val 
            180                 185                 190         


Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met 
        195                 200                 205             


His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
    210                 215                 220                 


Pro Gly Lys 
225         


<210>  17
<211>  734
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  sequence

<400>  17

Met Ile Pro Ala Arg Phe Ala Gly Val Leu Leu Ala Leu Ala Leu Ile 
1               5                   10                  15      


Leu Pro Gly Thr Leu Cys Ala Ser Leu Ser Cys Arg Pro Pro Met Val 
            20                  25                  30          


Lys Leu Val Cys Pro Ala Asp Asn Leu Arg Ala Glu Gly Leu Glu Cys 
        35                  40                  45              


Thr Lys Thr Cys Gln Asn Tyr Asp Leu Glu Cys Met Ser Met Gly Cys 
    50                  55                  60                  


Val Ser Gly Cys Leu Cys Pro Pro Gly Met Val Arg His Glu Asn Arg 
65                  70                  75                  80  


Cys Val Ala Leu Glu Arg Cys Pro Cys Phe His Gln Gly Lys Glu Tyr 
                85                  90                  95      


Ala Pro Gly Glu Thr Val Lys Ile Gly Cys Asn Thr Cys Val Cys Arg 
            100                 105                 110         


Asp Arg Lys Trp Asn Cys Thr Asp His Val Cys Asp Ala Thr Cys Ser 
        115                 120                 125             


Thr Ile Gly Met Ala His Tyr Leu Thr Phe Asp Gly Leu Lys Tyr Leu 
    130                 135                 140                 


Phe Pro Gly Glu Cys Gln Tyr Val Leu Val Gln Asp Tyr Cys Gly Ser 
145                 150                 155                 160 


Asn Pro Gly Thr Phe Arg Ile Leu Val Gly Asn Lys Gly Cys Ser His 
                165                 170                 175     


Pro Ser Val Lys Cys Lys Lys Arg Val Thr Ile Leu Val Glu Gly Gly 
            180                 185                 190         


Glu Ile Glu Leu Phe Asp Gly Glu Val Asn Val Lys Arg Pro Met Lys 
        195                 200                 205             


Asp Glu Thr His Phe Glu Val Val Glu Ser Gly Arg Tyr Ile Ile Leu 
    210                 215                 220                 


Leu Leu Gly Lys Ala Leu Ser Val Val Trp Asp Arg His Leu Ser Ile 
225                 230                 235                 240 


Ser Val Val Leu Lys Gln Thr Tyr Gln Glu Lys Val Cys Gly Leu Cys 
                245                 250                 255     


Gly Asn Phe Asp Gly Ile Gln Asn Asn Asp Leu Thr Ser Ser Asn Leu 
            260                 265                 270         


Gln Val Glu Glu Asp Pro Val Asp Phe Gly Asn Ser Trp Lys Val Ser 
        275                 280                 285             


Ser Gln Cys Ala Asp Thr Arg Lys Val Pro Leu Asp Ser Ser Pro Ala 
    290                 295                 300                 


Thr Cys His Asn Asn Ile Met Lys Gln Thr Met Val Asp Ser Ser Cys 
305                 310                 315                 320 


Arg Ile Leu Thr Ser Asp Val Phe Gln Asp Cys Asn Lys Leu Val Asp 
                325                 330                 335     


Pro Glu Pro Tyr Leu Asp Val Cys Ile Tyr Asp Thr Cys Ser Cys Glu 
            340                 345                 350         


Ser Ile Gly Asp Cys Ala Cys Phe Cys Asp Thr Ile Ala Ala Tyr Ala 
        355                 360                 365             


His Val Cys Ala Gln His Gly Lys Val Val Thr Trp Arg Thr Ala Thr 
    370                 375                 380                 


Leu Cys Pro Gln Ser Cys Glu Glu Arg Asn Leu Arg Glu Asn Gly Tyr 
385                 390                 395                 400 


Glu Cys Glu Trp Arg Tyr Asn Ser Cys Ala Pro Ala Cys Gln Val Thr 
                405                 410                 415     


Cys Gln His Pro Glu Pro Leu Ala Cys Pro Val Gln Cys Val Glu Gly 
            420                 425                 430         


Cys His Ala His Cys Pro Pro Gly Lys Ile Leu Asp Glu Leu Leu Gln 
        435                 440                 445             


Thr Cys Val Asp Pro Glu Asp Cys Pro Val Cys Glu Val Ala Gly Arg 
    450                 455                 460                 


Arg Phe Ala Ser Gly Lys Lys Val Thr Leu Asn Pro Ser Asp Pro Glu 
465                 470                 475                 480 


His Cys Gln Ile Cys His Cys Asp Val Val Asn Leu Thr Cys Glu Ala 
                485                 490                 495     


Cys Gln Glu Pro Gly Gly Leu Val Val Pro Pro Asp Lys Thr His Thr 
            500                 505                 510         


Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe 
        515                 520                 525             


Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro 
    530                 535                 540                 


Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val 
545                 550                 555                 560 


Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr 
                565                 570                 575     


Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val 
            580                 585                 590         


Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys 
        595                 600                 605             


Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser 
    610                 615                 620                 


Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro 
625                 630                 635                 640 


Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val 
                645                 650                 655     


Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly 
            660                 665                 670         


Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp 
        675                 680                 685             


Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp 
    690                 695                 700                 


Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His 
705                 710                 715                 720 


Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
                725                 730                 


<210>  18
<211>  968
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  sequence

<400>  18

Met Ile Pro Ala Arg Phe Ala Gly Val Leu Leu Ala Leu Ala Leu Ile 
1               5                   10                  15      


Leu Pro Gly Thr Leu Cys Ala Ser Leu Ser Cys Arg Pro Pro Met Val 
            20                  25                  30          


Lys Leu Val Cys Pro Ala Asp Asn Leu Arg Ala Glu Gly Leu Glu Cys 
        35                  40                  45              


Thr Lys Thr Cys Gln Asn Tyr Asp Leu Glu Cys Met Ser Met Gly Cys 
    50                  55                  60                  


Val Ser Gly Cys Leu Cys Pro Pro Gly Met Val Arg His Glu Asn Arg 
65                  70                  75                  80  


Cys Val Ala Leu Glu Arg Cys Pro Cys Phe His Gln Gly Lys Glu Tyr 
                85                  90                  95      


Ala Pro Gly Glu Thr Val Lys Ile Gly Cys Asn Thr Cys Val Cys Arg 
            100                 105                 110         


Asp Arg Lys Trp Asn Cys Thr Asp His Val Cys Asp Ala Thr Cys Ser 
        115                 120                 125             


Thr Ile Gly Met Ala His Tyr Leu Thr Phe Asp Gly Leu Lys Tyr Leu 
    130                 135                 140                 


Phe Pro Gly Glu Cys Gln Tyr Val Leu Val Gln Asp Tyr Cys Gly Ser 
145                 150                 155                 160 


Asn Pro Gly Thr Phe Arg Ile Leu Val Gly Asn Lys Gly Cys Ser His 
                165                 170                 175     


Pro Ser Val Lys Cys Lys Lys Arg Val Thr Ile Leu Val Glu Gly Gly 
            180                 185                 190         


Glu Ile Glu Leu Phe Asp Gly Glu Val Asn Val Lys Arg Pro Met Lys 
        195                 200                 205             


Asp Glu Thr His Phe Glu Val Val Glu Ser Gly Arg Tyr Ile Ile Leu 
    210                 215                 220                 


Leu Leu Gly Lys Ala Leu Ser Val Val Trp Asp Arg His Leu Ser Ile 
225                 230                 235                 240 


Ser Val Val Leu Lys Gln Thr Tyr Gln Glu Lys Val Cys Gly Leu Cys 
                245                 250                 255     


Gly Asn Phe Asp Gly Ile Gln Asn Asn Asp Leu Thr Ser Ser Asn Leu 
            260                 265                 270         


Gln Val Glu Glu Asp Pro Val Asp Phe Gly Asn Ser Trp Lys Val Ser 
        275                 280                 285             


Ser Gln Cys Ala Asp Thr Arg Lys Val Pro Leu Asp Ser Ser Pro Ala 
    290                 295                 300                 


Thr Cys His Asn Asn Ile Met Lys Gln Thr Met Val Asp Ser Ser Cys 
305                 310                 315                 320 


Arg Ile Leu Thr Ser Asp Val Phe Gln Asp Cys Asn Lys Leu Val Asp 
                325                 330                 335     


Pro Glu Pro Tyr Leu Asp Val Cys Ile Tyr Asp Thr Cys Ser Cys Glu 
            340                 345                 350         


Ser Ile Gly Asp Cys Ala Cys Phe Cys Asp Thr Ile Ala Ala Tyr Ala 
        355                 360                 365             


His Val Cys Ala Gln His Gly Lys Val Val Thr Trp Arg Thr Ala Thr 
    370                 375                 380                 


Leu Cys Pro Gln Ser Cys Glu Glu Arg Asn Leu Arg Glu Asn Gly Tyr 
385                 390                 395                 400 


Glu Cys Glu Trp Arg Tyr Asn Ser Cys Ala Pro Ala Cys Gln Val Thr 
                405                 410                 415     


Cys Gln His Pro Glu Pro Leu Ala Cys Pro Val Gln Cys Val Glu Gly 
            420                 425                 430         


Cys His Ala His Cys Pro Pro Gly Lys Ile Leu Asp Glu Leu Leu Gln 
        435                 440                 445             


Thr Cys Val Asp Pro Glu Asp Cys Pro Val Cys Glu Val Ala Gly Arg 
    450                 455                 460                 


Arg Phe Ala Ser Gly Lys Lys Val Thr Leu Asn Pro Ser Asp Pro Glu 
465                 470                 475                 480 


His Cys Gln Ile Cys His Cys Asp Val Val Asn Leu Thr Cys Glu Ala 
                485                 490                 495     


Cys Gln Glu Pro Gly Gly Leu Val Val Pro Pro Thr Asp Ala Pro Val 
            500                 505                 510         


Ser Pro Thr Thr Leu Tyr Val Glu Asp Ile Ser Glu Pro Pro Leu His 
        515                 520                 525             


Asp Phe Tyr Cys Ser Arg Leu Leu Asp Leu Val Phe Leu Leu Asp Gly 
    530                 535                 540                 


Ser Ser Arg Leu Ser Glu Ala Glu Phe Glu Val Leu Lys Ala Phe Val 
545                 550                 555                 560 


Val Asp Met Met Glu Arg Leu Arg Ile Ser Gln Lys Trp Val Arg Val 
                565                 570                 575     


Ala Val Val Glu Tyr His Asp Gly Ser His Ala Tyr Ile Gly Leu Lys 
            580                 585                 590         


Asp Arg Lys Arg Pro Ser Glu Leu Arg Arg Ile Ala Ser Gln Val Lys 
        595                 600                 605             


Tyr Ala Gly Ser Gln Val Ala Ser Thr Ser Glu Val Leu Lys Tyr Thr 
    610                 615                 620                 


Leu Phe Gln Ile Phe Ser Lys Ile Asp Arg Pro Glu Ala Ser Arg Ile 
625                 630                 635                 640 


Ala Leu Leu Leu Met Ala Ser Gln Glu Pro Gln Arg Met Ser Arg Asn 
                645                 650                 655     


Phe Val Arg Tyr Val Gln Gly Leu Lys Lys Lys Lys Val Ile Val Ile 
            660                 665                 670         


Pro Val Gly Ile Gly Pro His Ala Asn Leu Lys Gln Ile Arg Leu Ile 
        675                 680                 685             


Glu Lys Gln Ala Pro Glu Asn Lys Ala Phe Val Leu Ser Ser Val Asp 
    690                 695                 700                 


Glu Leu Glu Gln Gln Arg Asp Glu Ile Val Ser Tyr Leu Cys Asp Leu 
705                 710                 715                 720 


Ala Pro Glu Ala Pro Pro Pro Thr Leu Pro Pro His Met Ala Gln Val 
                725                 730                 735     


Thr Val Gly Pro Gly Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala 
            740                 745                 750         


Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 
        755                 760                 765             


Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 
    770                 775                 780                 


Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val 
785                 790                 795                 800 


Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 
                805                 810                 815     


Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln 
            820                 825                 830         


Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala 
        835                 840                 845             


Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro 
    850                 855                 860                 


Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr 
865                 870                 875                 880 


Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser 
                885                 890                 895     


Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 
            900                 905                 910         


Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr 
        915                 920                 925             


Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe 
    930                 935                 940                 


Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys 
945                 950                 955                 960 


Ser Leu Ser Leu Ser Pro Gly Lys 
                965             


<210>  19
<211>  1366
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  sequence

<400>  19

Met Ile Pro Ala Arg Phe Ala Gly Val Leu Leu Ala Leu Ala Leu Ile 
1               5                   10                  15      


Leu Pro Gly Thr Leu Cys Ala Ser Leu Ser Cys Arg Pro Pro Met Val 
            20                  25                  30          


Lys Leu Val Cys Pro Ala Asp Asn Leu Arg Ala Glu Gly Leu Glu Cys 
        35                  40                  45              


Thr Lys Thr Cys Gln Asn Tyr Asp Leu Glu Cys Met Ser Met Gly Cys 
    50                  55                  60                  


Val Ser Gly Cys Leu Cys Pro Pro Gly Met Val Arg His Glu Asn Arg 
65                  70                  75                  80  


Cys Val Ala Leu Glu Arg Cys Pro Cys Phe His Gln Gly Lys Glu Tyr 
                85                  90                  95      


Ala Pro Gly Glu Thr Val Lys Ile Gly Cys Asn Thr Cys Val Cys Arg 
            100                 105                 110         


Asp Arg Lys Trp Asn Cys Thr Asp His Val Cys Asp Ala Thr Cys Ser 
        115                 120                 125             


Thr Ile Gly Met Ala His Tyr Leu Thr Phe Asp Gly Leu Lys Tyr Leu 
    130                 135                 140                 


Phe Pro Gly Glu Cys Gln Tyr Val Leu Val Gln Asp Tyr Cys Gly Ser 
145                 150                 155                 160 


Asn Pro Gly Thr Phe Arg Ile Leu Val Gly Asn Lys Gly Cys Ser His 
                165                 170                 175     


Pro Ser Val Lys Cys Lys Lys Arg Val Thr Ile Leu Val Glu Gly Gly 
            180                 185                 190         


Glu Ile Glu Leu Phe Asp Gly Glu Val Asn Val Lys Arg Pro Met Lys 
        195                 200                 205             


Asp Glu Thr His Phe Glu Val Val Glu Ser Gly Arg Tyr Ile Ile Leu 
    210                 215                 220                 


Leu Leu Gly Lys Ala Leu Ser Val Val Trp Asp Arg His Leu Ser Ile 
225                 230                 235                 240 


Ser Val Val Leu Lys Gln Thr Tyr Gln Glu Lys Val Cys Gly Leu Cys 
                245                 250                 255     


Gly Asn Phe Asp Gly Ile Gln Asn Asn Asp Leu Thr Ser Ser Asn Leu 
            260                 265                 270         


Gln Val Glu Glu Asp Pro Val Asp Phe Gly Asn Ser Trp Lys Val Ser 
        275                 280                 285             


Ser Gln Cys Ala Asp Thr Arg Lys Val Pro Leu Asp Ser Ser Pro Ala 
    290                 295                 300                 


Thr Cys His Asn Asn Ile Met Lys Gln Thr Met Val Asp Ser Ser Cys 
305                 310                 315                 320 


Arg Ile Leu Thr Ser Asp Val Phe Gln Asp Cys Asn Lys Leu Val Asp 
                325                 330                 335     


Pro Glu Pro Tyr Leu Asp Val Cys Ile Tyr Asp Thr Cys Ser Cys Glu 
            340                 345                 350         


Ser Ile Gly Asp Cys Ala Cys Phe Cys Asp Thr Ile Ala Ala Tyr Ala 
        355                 360                 365             


His Val Cys Ala Gln His Gly Lys Val Val Thr Trp Arg Thr Ala Thr 
    370                 375                 380                 


Leu Cys Pro Gln Ser Cys Glu Glu Arg Asn Leu Arg Glu Asn Gly Tyr 
385                 390                 395                 400 


Glu Cys Glu Trp Arg Tyr Asn Ser Cys Ala Pro Ala Cys Gln Val Thr 
                405                 410                 415     


Cys Gln His Pro Glu Pro Leu Ala Cys Pro Val Gln Cys Val Glu Gly 
            420                 425                 430         


Cys His Ala His Cys Pro Pro Gly Lys Ile Leu Asp Glu Leu Leu Gln 
        435                 440                 445             


Thr Cys Val Asp Pro Glu Asp Cys Pro Val Cys Glu Val Ala Gly Arg 
    450                 455                 460                 


Arg Phe Ala Ser Gly Lys Lys Val Thr Leu Asn Pro Ser Asp Pro Glu 
465                 470                 475                 480 


His Cys Gln Ile Cys His Cys Asp Val Val Asn Leu Thr Cys Glu Ala 
                485                 490                 495     


Cys Gln Glu Pro Gly Gly Leu Val Val Pro Pro Thr Asp Ala Pro Val 
            500                 505                 510         


Ser Pro Thr Thr Leu Tyr Val Glu Asp Ile Ser Glu Pro Pro Leu His 
        515                 520                 525             


Asp Phe Tyr Cys Ser Arg Leu Leu Asp Leu Val Phe Leu Leu Asp Gly 
    530                 535                 540                 


Ser Ser Arg Leu Ser Glu Ala Glu Phe Glu Val Leu Lys Ala Phe Val 
545                 550                 555                 560 


Val Asp Met Met Glu Arg Leu Arg Ile Ser Gln Lys Trp Val Arg Val 
                565                 570                 575     


Ala Val Val Glu Tyr His Asp Gly Ser His Ala Tyr Ile Gly Leu Lys 
            580                 585                 590         


Asp Arg Lys Arg Pro Ser Glu Leu Arg Arg Ile Ala Ser Gln Val Lys 
        595                 600                 605             


Tyr Ala Gly Ser Gln Val Ala Ser Thr Ser Glu Val Leu Lys Tyr Thr 
    610                 615                 620                 


Leu Phe Gln Ile Phe Ser Lys Ile Asp Arg Pro Glu Ala Ser Arg Ile 
625                 630                 635                 640 


Ala Leu Leu Leu Met Ala Ser Gln Glu Pro Gln Arg Met Ser Arg Asn 
                645                 650                 655     


Phe Val Arg Tyr Val Gln Gly Leu Lys Lys Lys Lys Val Ile Val Ile 
            660                 665                 670         


Pro Val Gly Ile Gly Pro His Ala Asn Leu Lys Gln Ile Arg Leu Ile 
        675                 680                 685             


Glu Lys Gln Ala Pro Glu Asn Lys Ala Phe Val Leu Ser Ser Val Asp 
    690                 695                 700                 


Glu Leu Glu Gln Gln Arg Asp Glu Ile Val Ser Tyr Leu Cys Asp Leu 
705                 710                 715                 720 


Ala Pro Glu Ala Pro Pro Pro Thr Leu Pro Pro His Met Ala Gln Val 
                725                 730                 735     


Thr Val Gly Pro Gly Leu Leu Gly Val Ser Thr Leu Gly Pro Lys Arg 
            740                 745                 750         


Asn Ser Met Val Leu Asp Val Ala Phe Val Leu Glu Gly Ser Asp Lys 
        755                 760                 765             


Ile Gly Glu Ala Asp Phe Asn Arg Ser Lys Glu Phe Met Glu Glu Val 
    770                 775                 780                 


Ile Gln Arg Met Asp Val Gly Gln Asp Ser Ile His Val Thr Val Leu 
785                 790                 795                 800 


Gln Tyr Ser Tyr Met Val Thr Val Glu Tyr Pro Phe Ser Glu Ala Gln 
                805                 810                 815     


Ser Lys Gly Asp Ile Leu Gln Arg Val Arg Glu Ile Arg Tyr Gln Gly 
            820                 825                 830         


Gly Asn Arg Thr Asn Thr Gly Leu Ala Leu Arg Tyr Leu Ser Asp His 
        835                 840                 845             


Ser Phe Leu Val Ser Gln Gly Asp Arg Glu Gln Ala Pro Asn Leu Val 
    850                 855                 860                 


Tyr Met Val Thr Gly Asn Pro Ala Ser Asp Glu Ile Lys Arg Leu Pro 
865                 870                 875                 880 


Gly Asp Ile Gln Val Val Pro Ile Gly Val Gly Pro Asn Ala Asn Val 
                885                 890                 895     


Gln Glu Leu Glu Arg Ile Gly Trp Pro Asn Ala Pro Ile Leu Ile Gln 
            900                 905                 910         


Asp Phe Glu Thr Leu Pro Arg Glu Ala Pro Asp Leu Val Leu Gln Arg 
        915                 920                 925             


Cys Cys Ser Gly Glu Gly Leu Gln Ile Pro Thr Leu Ser Pro Ala Pro 
    930                 935                 940                 


Asp Cys Ser Gln Pro Leu Asp Val Ile Leu Leu Leu Asp Gly Ser Ser 
945                 950                 955                 960 


Ser Phe Pro Ala Ser Tyr Phe Asp Glu Met Lys Ser Phe Ala Lys Ala 
                965                 970                 975     


Phe Ile Ser Lys Ala Asn Ile Gly Pro Arg Leu Thr Gln Val Ser Val 
            980                 985                 990         


Leu Gln Tyr Gly Ser Ile Thr Thr  Ile Asp Val Pro Trp  Asn Val Val 
        995                 1000                 1005             


Pro Glu  Lys Ala His Leu Leu  Ser Leu Val Asp Val  Met Gln Arg 
    1010                 1015                 1020             


Glu Gly  Gly Pro Ser Gln Ile  Gly Asp Ala Leu Gly  Phe Ala Val 
    1025                 1030                 1035             


Arg Tyr  Leu Thr Ser Glu Met  His Gly Ala Arg Pro  Gly Ala Ser 
    1040                 1045                 1050             


Lys Ala  Val Val Ile Leu Val  Thr Asp Val Ser Val  Asp Ser Val 
    1055                 1060                 1065             


Asp Ala  Ala Ala Asp Ala Ala  Arg Ser Asn Arg Val  Thr Val Phe 
    1070                 1075                 1080             


Pro Ile  Gly Ile Gly Asp Arg  Tyr Asp Ala Ala Gln  Leu Arg Ile 
    1085                 1090                 1095             


Leu Ala  Gly Pro Ala Gly Asp  Ser Asn Val Val Lys  Leu Gln Arg 
    1100                 1105                 1110             


Ile Glu  Asp Leu Pro Thr Met  Val Thr Leu Gly Asn  Ser Phe Leu 
    1115                 1120                 1125             


His Lys  Leu Cys Ser Gly Phe  Val Arg Ile Cys Asp  Lys Thr His 
    1130                 1135                 1140             


Thr Cys  Pro Pro Cys Pro Ala  Pro Glu Leu Leu Gly  Gly Pro Ser 
    1145                 1150                 1155             


Val Phe  Leu Phe Pro Pro Lys  Pro Lys Asp Thr Leu  Met Ile Ser 
    1160                 1165                 1170             


Arg Thr  Pro Glu Val Thr Cys  Val Val Val Asp Val  Ser His Glu 
    1175                 1180                 1185             


Asp Pro  Glu Val Lys Phe Asn  Trp Tyr Val Asp Gly  Val Glu Val 
    1190                 1195                 1200             


His Asn  Ala Lys Thr Lys Pro  Arg Glu Glu Gln Tyr  Asn Ser Thr 
    1205                 1210                 1215             


Tyr Arg  Val Val Ser Val Leu  Thr Val Leu His Gln  Asp Trp Leu 
    1220                 1225                 1230             


Asn Gly  Lys Glu Tyr Lys Cys  Lys Val Ser Asn Lys  Ala Leu Pro 
    1235                 1240                 1245             


Ala Pro  Ile Glu Lys Thr Ile  Ser Lys Ala Lys Gly  Gln Pro Arg 
    1250                 1255                 1260             


Glu Pro  Gln Val Tyr Thr Leu  Pro Pro Ser Arg Asp  Glu Leu Thr 
    1265                 1270                 1275             


Lys Asn  Gln Val Ser Leu Thr  Cys Leu Val Lys Gly  Phe Tyr Pro 
    1280                 1285                 1290             


Ser Asp  Ile Ala Val Glu Trp  Glu Ser Asn Gly Gln  Pro Glu Asn 
    1295                 1300                 1305             


Asn Tyr  Lys Thr Thr Pro Pro  Val Leu Asp Ser Asp  Gly Ser Phe 
    1310                 1315                 1320             


Phe Leu  Tyr Ser Lys Leu Thr  Val Asp Lys Ser Arg  Trp Gln Gln 
    1325                 1330                 1335             


Gly Asn  Val Phe Ser Cys Ser  Val Met His Glu Ala  Leu His Asn 
    1340                 1345                 1350             


His Tyr  Thr Gln Lys Ser Leu  Ser Leu Ser Pro Gly  Lys 
    1355                 1360                 1365     


<210>  20
<211>  1474
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  sequence

<400>  20

Met Ile Pro Ala Arg Phe Ala Gly Val Leu Leu Ala Leu Ala Leu Ile 
1               5                   10                  15      


Leu Pro Gly Thr Leu Cys Ala Glu Gly Thr Arg Gly Arg Ser Ser Thr 
            20                  25                  30          


Ala Arg Cys Ser Leu Phe Gly Ser Asp Phe Val Asn Thr Phe Asp Gly 
        35                  40                  45              


Ser Met Tyr Ser Phe Ala Gly Tyr Cys Ser Tyr Leu Leu Ala Gly Gly 
    50                  55                  60                  


Cys Gln Lys Arg Ser Phe Ser Ile Ile Gly Asp Phe Gln Asn Gly Lys 
65                  70                  75                  80  


Arg Val Ser Leu Ser Val Tyr Leu Gly Glu Phe Phe Asp Ile His Leu 
                85                  90                  95      


Phe Val Asn Gly Thr Val Thr Gln Gly Asp Gln Arg Val Ser Met Pro 
            100                 105                 110         


Tyr Ala Ser Lys Gly Leu Tyr Leu Glu Thr Glu Ala Gly Tyr Tyr Lys 
        115                 120                 125             


Leu Ser Gly Glu Ala Tyr Gly Phe Val Ala Arg Ile Asp Gly Ser Gly 
    130                 135                 140                 


Asn Phe Gln Val Leu Leu Ser Asp Arg Tyr Phe Asn Lys Thr Cys Gly 
145                 150                 155                 160 


Leu Cys Gly Asn Phe Asn Ile Phe Ala Glu Asp Asp Phe Met Thr Gln 
                165                 170                 175     


Glu Gly Thr Leu Thr Ser Asp Pro Tyr Asp Phe Ala Asn Ser Trp Ala 
            180                 185                 190         


Leu Ser Ser Gly Glu Gln Trp Cys Glu Arg Ala Ser Pro Pro Ser Ser 
        195                 200                 205             


Ser Cys Asn Ile Ser Ser Gly Glu Met Gln Lys Gly Leu Trp Glu Gln 
    210                 215                 220                 


Cys Gln Leu Leu Lys Ser Thr Ser Val Phe Ala Arg Cys His Pro Leu 
225                 230                 235                 240 


Val Asp Pro Glu Pro Phe Val Ala Leu Cys Glu Lys Thr Leu Cys Glu 
                245                 250                 255     


Cys Ala Gly Gly Leu Glu Cys Ala Cys Pro Ala Leu Leu Glu Tyr Ala 
            260                 265                 270         


Arg Thr Cys Ala Gln Glu Gly Met Val Leu Tyr Gly Trp Thr Asp His 
        275                 280                 285             


Ser Ala Cys Ser Pro Val Cys Pro Ala Gly Met Glu Tyr Arg Gln Cys 
    290                 295                 300                 


Val Ser Pro Cys Ala Arg Thr Cys Gln Ser Leu His Ile Asn Glu Met 
305                 310                 315                 320 


Cys Gln Glu Arg Cys Val Asp Gly Cys Ser Cys Pro Glu Gly Gln Leu 
                325                 330                 335     


Leu Asp Glu Gly Leu Cys Val Glu Ser Thr Glu Cys Pro Cys Val His 
            340                 345                 350         


Ser Gly Lys Arg Tyr Pro Pro Gly Thr Ser Leu Ser Arg Asp Cys Asn 
        355                 360                 365             


Thr Cys Ile Cys Arg Asn Ser Gln Trp Ile Cys Ser Asn Glu Glu Cys 
    370                 375                 380                 


Pro Gly Glu Cys Leu Val Thr Gly Gln Ser His Phe Lys Ser Phe Asp 
385                 390                 395                 400 


Asn Arg Tyr Phe Thr Phe Ser Gly Ile Cys Gln Tyr Leu Leu Ala Arg 
                405                 410                 415     


Asp Cys Gln Asp His Ser Phe Ser Ile Val Ile Glu Thr Val Gln Cys 
            420                 425                 430         


Ala Asp Asp Arg Asp Ala Val Cys Thr Arg Ser Val Thr Val Arg Leu 
        435                 440                 445             


Pro Gly Leu His Asn Ser Leu Val Lys Leu Lys His Gly Ala Gly Val 
    450                 455                 460                 


Ala Met Asp Gly Gln Asp Ile Gln Leu Pro Leu Leu Lys Gly Asp Leu 
465                 470                 475                 480 


Arg Ile Gln His Thr Val Thr Ala Ser Val Arg Leu Ser Tyr Gly Glu 
                485                 490                 495     


Asp Leu Gln Met Asp Trp Asp Gly Arg Gly Arg Leu Leu Val Lys Leu 
            500                 505                 510         


Ser Pro Val Tyr Ala Gly Lys Thr Cys Gly Leu Cys Gly Asn Tyr Asn 
        515                 520                 525             


Gly Asn Gln Gly Asp Asp Phe Leu Thr Pro Ser Gly Leu Ala Glu Pro 
    530                 535                 540                 


Arg Val Glu Asp Phe Gly Asn Ala Trp Lys Leu His Gly Asp Cys Gln 
545                 550                 555                 560 


Asp Leu Gln Lys Gln His Ser Asp Pro Cys Ala Leu Asn Pro Arg Met 
                565                 570                 575     


Thr Arg Phe Ser Glu Glu Ala Cys Ala Val Leu Thr Ser Pro Thr Phe 
            580                 585                 590         


Glu Ala Cys His Arg Ala Val Ser Pro Leu Pro Tyr Leu Arg Asn Cys 
        595                 600                 605             


Arg Tyr Asp Val Cys Ser Cys Ser Asp Gly Arg Glu Cys Leu Cys Gly 
    610                 615                 620                 


Ala Leu Ala Ser Tyr Ala Ala Ala Cys Ala Gly Arg Gly Val Arg Val 
625                 630                 635                 640 


Ala Trp Arg Glu Pro Gly Arg Cys Glu Leu Asn Cys Pro Lys Gly Gln 
                645                 650                 655     


Val Tyr Leu Gln Cys Gly Thr Pro Cys Asn Leu Thr Cys Arg Ser Leu 
            660                 665                 670         


Ser Tyr Pro Asp Glu Glu Cys Asn Glu Ala Cys Leu Glu Gly Cys Phe 
        675                 680                 685             


Cys Pro Pro Gly Leu Tyr Met Asp Glu Arg Gly Asp Cys Val Pro Lys 
    690                 695                 700                 


Ala Gln Cys Pro Cys Tyr Tyr Asp Gly Glu Ile Phe Gln Pro Glu Asp 
705                 710                 715                 720 


Ile Phe Ser Asp His His Thr Met Cys Tyr Cys Glu Asp Gly Phe Met 
                725                 730                 735     


His Cys Thr Met Ser Gly Val Pro Gly Ser Leu Leu Pro Asp Ala Val 
            740                 745                 750         


Leu Ser Ser Pro Leu Ser His Arg Ser Lys Arg Ser Leu Ser Cys Arg 
        755                 760                 765             


Pro Pro Met Val Lys Leu Val Cys Pro Ala Asp Asn Leu Arg Ala Glu 
    770                 775                 780                 


Gly Leu Glu Cys Thr Lys Thr Cys Gln Asn Tyr Asp Leu Glu Cys Met 
785                 790                 795                 800 


Ser Met Gly Cys Val Ser Gly Cys Leu Cys Pro Pro Gly Met Val Arg 
                805                 810                 815     


His Glu Asn Arg Cys Val Ala Leu Glu Arg Cys Pro Cys Phe His Gln 
            820                 825                 830         


Gly Lys Glu Tyr Ala Pro Gly Glu Thr Val Lys Ile Gly Cys Asn Thr 
        835                 840                 845             


Cys Val Cys Arg Asp Arg Lys Trp Asn Cys Thr Asp His Val Cys Asp 
    850                 855                 860                 


Ala Thr Cys Ser Thr Ile Gly Met Ala His Tyr Leu Thr Phe Asp Gly 
865                 870                 875                 880 


Leu Lys Tyr Leu Phe Pro Gly Glu Cys Gln Tyr Val Leu Val Gln Asp 
                885                 890                 895     


Tyr Cys Gly Ser Asn Pro Gly Thr Phe Arg Ile Leu Val Gly Asn Lys 
            900                 905                 910         


Gly Cys Ser His Pro Ser Val Lys Cys Lys Lys Arg Val Thr Ile Leu 
        915                 920                 925             


Val Glu Gly Gly Glu Ile Glu Leu Phe Asp Gly Glu Val Asn Val Lys 
    930                 935                 940                 


Arg Pro Met Lys Asp Glu Thr His Phe Glu Val Val Glu Ser Gly Arg 
945                 950                 955                 960 


Tyr Ile Ile Leu Leu Leu Gly Lys Ala Leu Ser Val Val Trp Asp Arg 
                965                 970                 975     


His Leu Ser Ile Ser Val Val Leu Lys Gln Thr Tyr Gln Glu Lys Val 
            980                 985                 990         


Cys Gly Leu Cys Gly Asn Phe Asp  Gly Ile Gln Asn Asn  Asp Leu Thr 
        995                 1000                 1005             


Ser Ser  Asn Leu Gln Val Glu  Glu Asp Pro Val Asp  Phe Gly Asn 
    1010                 1015                 1020             


Ser Trp  Lys Val Ser Ser Gln  Cys Ala Asp Thr Arg  Lys Val Pro 
    1025                 1030                 1035             


Leu Asp  Ser Ser Pro Ala Thr  Cys His Asn Asn Ile  Met Lys Gln 
    1040                 1045                 1050             


Thr Met  Val Asp Ser Ser Cys  Arg Ile Leu Thr Ser  Asp Val Phe 
    1055                 1060                 1065             


Gln Asp  Cys Asn Lys Leu Val  Asp Pro Glu Pro Tyr  Leu Asp Val 
    1070                 1075                 1080             


Cys Ile  Tyr Asp Thr Cys Ser  Cys Glu Ser Ile Gly  Asp Cys Ala 
    1085                 1090                 1095             


Cys Phe  Cys Asp Thr Ile Ala  Ala Tyr Ala His Val  Cys Ala Gln 
    1100                 1105                 1110             


His Gly  Lys Val Val Thr Trp  Arg Thr Ala Thr Leu  Cys Pro Gln 
    1115                 1120                 1125             


Ser Cys  Glu Glu Arg Asn Leu  Arg Glu Asn Gly Tyr  Glu Cys Glu 
    1130                 1135                 1140             


Trp Arg  Tyr Asn Ser Cys Ala  Pro Ala Cys Gln Val  Thr Cys Gln 
    1145                 1150                 1155             


His Pro  Glu Pro Leu Ala Cys  Pro Val Gln Cys Val  Glu Gly Cys 
    1160                 1165                 1170             


His Ala  His Cys Pro Pro Gly  Lys Ile Leu Asp Glu  Leu Leu Gln 
    1175                 1180                 1185             


Thr Cys  Val Asp Pro Glu Asp  Cys Pro Val Cys Glu  Val Ala Gly 
    1190                 1195                 1200             


Arg Arg  Phe Ala Ser Gly Lys  Lys Val Thr Leu Asn  Pro Ser Asp 
    1205                 1210                 1215             


Pro Glu  His Cys Gln Ile Cys  His Cys Asp Val Val  Asn Leu Thr 
    1220                 1225                 1230             


Cys Glu  Ala Cys Gln Glu Pro  Gly Gly Leu Val Val  Pro Pro Asp 
    1235                 1240                 1245             


Lys Thr  His Thr Cys Pro Pro  Cys Pro Ala Pro Glu  Leu Leu Gly 
    1250                 1255                 1260             


Gly Pro  Ser Val Phe Leu Phe  Pro Pro Lys Pro Lys  Asp Thr Leu 
    1265                 1270                 1275             


Met Ile  Ser Arg Thr Pro Glu  Val Thr Cys Val Val  Val Asp Val 
    1280                 1285                 1290             


Ser His  Glu Asp Pro Glu Val  Lys Phe Asn Trp Tyr  Val Asp Gly 
    1295                 1300                 1305             


Val Glu  Val His Asn Ala Lys  Thr Lys Pro Arg Glu  Glu Gln Tyr 
    1310                 1315                 1320             


Asn Ser  Thr Tyr Arg Val Val  Ser Val Leu Thr Val  Leu His Gln 
    1325                 1330                 1335             


Asp Trp  Leu Asn Gly Lys Glu  Tyr Lys Cys Lys Val  Ser Asn Lys 
    1340                 1345                 1350             


Ala Leu  Pro Ala Pro Ile Glu  Lys Thr Ile Ser Lys  Ala Lys Gly 
    1355                 1360                 1365             


Gln Pro  Arg Glu Pro Gln Val  Tyr Thr Leu Pro Pro  Ser Arg Asp 
    1370                 1375                 1380             


Glu Leu  Thr Lys Asn Gln Val  Ser Leu Thr Cys Leu  Val Lys Gly 
    1385                 1390                 1395             


Phe Tyr  Pro Ser Asp Ile Ala  Val Glu Trp Glu Ser  Asn Gly Gln 
    1400                 1405                 1410             


Pro Glu  Asn Asn Tyr Lys Thr  Thr Pro Pro Val Leu  Asp Ser Asp 
    1415                 1420                 1425             


Gly Ser  Phe Phe Leu Tyr Ser  Lys Leu Thr Val Asp  Lys Ser Arg 
    1430                 1435                 1440             


Trp Gln  Gln Gly Asn Val Phe  Ser Cys Ser Val Met  His Glu Ala 
    1445                 1450                 1455             


Leu His  Asn His Tyr Thr Gln  Lys Ser Leu Ser Leu  Ser Pro Gly 
    1460                 1465                 1470             


Lys 
    


<210>  21
<211>  1708
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  sequence

<400>  21

Met Ile Pro Ala Arg Phe Ala Gly Val Leu Leu Ala Leu Ala Leu Ile 
1               5                   10                  15      


Leu Pro Gly Thr Leu Cys Ala Glu Gly Thr Arg Gly Arg Ser Ser Thr 
            20                  25                  30          


Ala Arg Cys Ser Leu Phe Gly Ser Asp Phe Val Asn Thr Phe Asp Gly 
        35                  40                  45              


Ser Met Tyr Ser Phe Ala Gly Tyr Cys Ser Tyr Leu Leu Ala Gly Gly 
    50                  55                  60                  


Cys Gln Lys Arg Ser Phe Ser Ile Ile Gly Asp Phe Gln Asn Gly Lys 
65                  70                  75                  80  


Arg Val Ser Leu Ser Val Tyr Leu Gly Glu Phe Phe Asp Ile His Leu 
                85                  90                  95      


Phe Val Asn Gly Thr Val Thr Gln Gly Asp Gln Arg Val Ser Met Pro 
            100                 105                 110         


Tyr Ala Ser Lys Gly Leu Tyr Leu Glu Thr Glu Ala Gly Tyr Tyr Lys 
        115                 120                 125             


Leu Ser Gly Glu Ala Tyr Gly Phe Val Ala Arg Ile Asp Gly Ser Gly 
    130                 135                 140                 


Asn Phe Gln Val Leu Leu Ser Asp Arg Tyr Phe Asn Lys Thr Cys Gly 
145                 150                 155                 160 


Leu Cys Gly Asn Phe Asn Ile Phe Ala Glu Asp Asp Phe Met Thr Gln 
                165                 170                 175     


Glu Gly Thr Leu Thr Ser Asp Pro Tyr Asp Phe Ala Asn Ser Trp Ala 
            180                 185                 190         


Leu Ser Ser Gly Glu Gln Trp Cys Glu Arg Ala Ser Pro Pro Ser Ser 
        195                 200                 205             


Ser Cys Asn Ile Ser Ser Gly Glu Met Gln Lys Gly Leu Trp Glu Gln 
    210                 215                 220                 


Cys Gln Leu Leu Lys Ser Thr Ser Val Phe Ala Arg Cys His Pro Leu 
225                 230                 235                 240 


Val Asp Pro Glu Pro Phe Val Ala Leu Cys Glu Lys Thr Leu Cys Glu 
                245                 250                 255     


Cys Ala Gly Gly Leu Glu Cys Ala Cys Pro Ala Leu Leu Glu Tyr Ala 
            260                 265                 270         


Arg Thr Cys Ala Gln Glu Gly Met Val Leu Tyr Gly Trp Thr Asp His 
        275                 280                 285             


Ser Ala Cys Ser Pro Val Cys Pro Ala Gly Met Glu Tyr Arg Gln Cys 
    290                 295                 300                 


Val Ser Pro Cys Ala Arg Thr Cys Gln Ser Leu His Ile Asn Glu Met 
305                 310                 315                 320 


Cys Gln Glu Arg Cys Val Asp Gly Cys Ser Cys Pro Glu Gly Gln Leu 
                325                 330                 335     


Leu Asp Glu Gly Leu Cys Val Glu Ser Thr Glu Cys Pro Cys Val His 
            340                 345                 350         


Ser Gly Lys Arg Tyr Pro Pro Gly Thr Ser Leu Ser Arg Asp Cys Asn 
        355                 360                 365             


Thr Cys Ile Cys Arg Asn Ser Gln Trp Ile Cys Ser Asn Glu Glu Cys 
    370                 375                 380                 


Pro Gly Glu Cys Leu Val Thr Gly Gln Ser His Phe Lys Ser Phe Asp 
385                 390                 395                 400 


Asn Arg Tyr Phe Thr Phe Ser Gly Ile Cys Gln Tyr Leu Leu Ala Arg 
                405                 410                 415     


Asp Cys Gln Asp His Ser Phe Ser Ile Val Ile Glu Thr Val Gln Cys 
            420                 425                 430         


Ala Asp Asp Arg Asp Ala Val Cys Thr Arg Ser Val Thr Val Arg Leu 
        435                 440                 445             


Pro Gly Leu His Asn Ser Leu Val Lys Leu Lys His Gly Ala Gly Val 
    450                 455                 460                 


Ala Met Asp Gly Gln Asp Ile Gln Leu Pro Leu Leu Lys Gly Asp Leu 
465                 470                 475                 480 


Arg Ile Gln His Thr Val Thr Ala Ser Val Arg Leu Ser Tyr Gly Glu 
                485                 490                 495     


Asp Leu Gln Met Asp Trp Asp Gly Arg Gly Arg Leu Leu Val Lys Leu 
            500                 505                 510         


Ser Pro Val Tyr Ala Gly Lys Thr Cys Gly Leu Cys Gly Asn Tyr Asn 
        515                 520                 525             


Gly Asn Gln Gly Asp Asp Phe Leu Thr Pro Ser Gly Leu Ala Glu Pro 
    530                 535                 540                 


Arg Val Glu Asp Phe Gly Asn Ala Trp Lys Leu His Gly Asp Cys Gln 
545                 550                 555                 560 


Asp Leu Gln Lys Gln His Ser Asp Pro Cys Ala Leu Asn Pro Arg Met 
                565                 570                 575     


Thr Arg Phe Ser Glu Glu Ala Cys Ala Val Leu Thr Ser Pro Thr Phe 
            580                 585                 590         


Glu Ala Cys His Arg Ala Val Ser Pro Leu Pro Tyr Leu Arg Asn Cys 
        595                 600                 605             


Arg Tyr Asp Val Cys Ser Cys Ser Asp Gly Arg Glu Cys Leu Cys Gly 
    610                 615                 620                 


Ala Leu Ala Ser Tyr Ala Ala Ala Cys Ala Gly Arg Gly Val Arg Val 
625                 630                 635                 640 


Ala Trp Arg Glu Pro Gly Arg Cys Glu Leu Asn Cys Pro Lys Gly Gln 
                645                 650                 655     


Val Tyr Leu Gln Cys Gly Thr Pro Cys Asn Leu Thr Cys Arg Ser Leu 
            660                 665                 670         


Ser Tyr Pro Asp Glu Glu Cys Asn Glu Ala Cys Leu Glu Gly Cys Phe 
        675                 680                 685             


Cys Pro Pro Gly Leu Tyr Met Asp Glu Arg Gly Asp Cys Val Pro Lys 
    690                 695                 700                 


Ala Gln Cys Pro Cys Tyr Tyr Asp Gly Glu Ile Phe Gln Pro Glu Asp 
705                 710                 715                 720 


Ile Phe Ser Asp His His Thr Met Cys Tyr Cys Glu Asp Gly Phe Met 
                725                 730                 735     


His Cys Thr Met Ser Gly Val Pro Gly Ser Leu Leu Pro Asp Ala Val 
            740                 745                 750         


Leu Ser Ser Pro Leu Ser His Arg Ser Lys Arg Ser Leu Ser Cys Arg 
        755                 760                 765             


Pro Pro Met Val Lys Leu Val Cys Pro Ala Asp Asn Leu Arg Ala Glu 
    770                 775                 780                 


Gly Leu Glu Cys Thr Lys Thr Cys Gln Asn Tyr Asp Leu Glu Cys Met 
785                 790                 795                 800 


Ser Met Gly Cys Val Ser Gly Cys Leu Cys Pro Pro Gly Met Val Arg 
                805                 810                 815     


His Glu Asn Arg Cys Val Ala Leu Glu Arg Cys Pro Cys Phe His Gln 
            820                 825                 830         


Gly Lys Glu Tyr Ala Pro Gly Glu Thr Val Lys Ile Gly Cys Asn Thr 
        835                 840                 845             


Cys Val Cys Arg Asp Arg Lys Trp Asn Cys Thr Asp His Val Cys Asp 
    850                 855                 860                 


Ala Thr Cys Ser Thr Ile Gly Met Ala His Tyr Leu Thr Phe Asp Gly 
865                 870                 875                 880 


Leu Lys Tyr Leu Phe Pro Gly Glu Cys Gln Tyr Val Leu Val Gln Asp 
                885                 890                 895     


Tyr Cys Gly Ser Asn Pro Gly Thr Phe Arg Ile Leu Val Gly Asn Lys 
            900                 905                 910         


Gly Cys Ser His Pro Ser Val Lys Cys Lys Lys Arg Val Thr Ile Leu 
        915                 920                 925             


Val Glu Gly Gly Glu Ile Glu Leu Phe Asp Gly Glu Val Asn Val Lys 
    930                 935                 940                 


Arg Pro Met Lys Asp Glu Thr His Phe Glu Val Val Glu Ser Gly Arg 
945                 950                 955                 960 


Tyr Ile Ile Leu Leu Leu Gly Lys Ala Leu Ser Val Val Trp Asp Arg 
                965                 970                 975     


His Leu Ser Ile Ser Val Val Leu Lys Gln Thr Tyr Gln Glu Lys Val 
            980                 985                 990         


Cys Gly Leu Cys Gly Asn Phe Asp  Gly Ile Gln Asn Asn  Asp Leu Thr 
        995                 1000                 1005             


Ser Ser  Asn Leu Gln Val Glu  Glu Asp Pro Val Asp  Phe Gly Asn 
    1010                 1015                 1020             


Ser Trp  Lys Val Ser Ser Gln  Cys Ala Asp Thr Arg  Lys Val Pro 
    1025                 1030                 1035             


Leu Asp  Ser Ser Pro Ala Thr  Cys His Asn Asn Ile  Met Lys Gln 
    1040                 1045                 1050             


Thr Met  Val Asp Ser Ser Cys  Arg Ile Leu Thr Ser  Asp Val Phe 
    1055                 1060                 1065             


Gln Asp  Cys Asn Lys Leu Val  Asp Pro Glu Pro Tyr  Leu Asp Val 
    1070                 1075                 1080             


Cys Ile  Tyr Asp Thr Cys Ser  Cys Glu Ser Ile Gly  Asp Cys Ala 
    1085                 1090                 1095             


Cys Phe  Cys Asp Thr Ile Ala  Ala Tyr Ala His Val  Cys Ala Gln 
    1100                 1105                 1110             


His Gly  Lys Val Val Thr Trp  Arg Thr Ala Thr Leu  Cys Pro Gln 
    1115                 1120                 1125             


Ser Cys  Glu Glu Arg Asn Leu  Arg Glu Asn Gly Tyr  Glu Cys Glu 
    1130                 1135                 1140             


Trp Arg  Tyr Asn Ser Cys Ala  Pro Ala Cys Gln Val  Thr Cys Gln 
    1145                 1150                 1155             


His Pro  Glu Pro Leu Ala Cys  Pro Val Gln Cys Val  Glu Gly Cys 
    1160                 1165                 1170             


His Ala  His Cys Pro Pro Gly  Lys Ile Leu Asp Glu  Leu Leu Gln 
    1175                 1180                 1185             


Thr Cys  Val Asp Pro Glu Asp  Cys Pro Val Cys Glu  Val Ala Gly 
    1190                 1195                 1200             


Arg Arg  Phe Ala Ser Gly Lys  Lys Val Thr Leu Asn  Pro Ser Asp 
    1205                 1210                 1215             


Pro Glu  His Cys Gln Ile Cys  His Cys Asp Val Val  Asn Leu Thr 
    1220                 1225                 1230             


Cys Glu  Ala Cys Gln Glu Pro  Gly Gly Leu Val Val  Pro Pro Thr 
    1235                 1240                 1245             


Asp Ala  Pro Val Ser Pro Thr  Thr Leu Tyr Val Glu  Asp Ile Ser 
    1250                 1255                 1260             


Glu Pro  Pro Leu His Asp Phe  Tyr Cys Ser Arg Leu  Leu Asp Leu 
    1265                 1270                 1275             


Val Phe  Leu Leu Asp Gly Ser  Ser Arg Leu Ser Glu  Ala Glu Phe 
    1280                 1285                 1290             


Glu Val  Leu Lys Ala Phe Val  Val Asp Met Met Glu  Arg Leu Arg 
    1295                 1300                 1305             


Ile Ser  Gln Lys Trp Val Arg  Val Ala Val Val Glu  Tyr His Asp 
    1310                 1315                 1320             


Gly Ser  His Ala Tyr Ile Gly  Leu Lys Asp Arg Lys  Arg Pro Ser 
    1325                 1330                 1335             


Glu Leu  Arg Arg Ile Ala Ser  Gln Val Lys Tyr Ala  Gly Ser Gln 
    1340                 1345                 1350             


Val Ala  Ser Thr Ser Glu Val  Leu Lys Tyr Thr Leu  Phe Gln Ile 
    1355                 1360                 1365             


Phe Ser  Lys Ile Asp Arg Pro  Glu Ala Ser Arg Ile  Ala Leu Leu 
    1370                 1375                 1380             


Leu Met  Ala Ser Gln Glu Pro  Gln Arg Met Ser Arg  Asn Phe Val 
    1385                 1390                 1395             


Arg Tyr  Val Gln Gly Leu Lys  Lys Lys Lys Val Ile  Val Ile Pro 
    1400                 1405                 1410             


Val Gly  Ile Gly Pro His Ala  Asn Leu Lys Gln Ile  Arg Leu Ile 
    1415                 1420                 1425             


Glu Lys  Gln Ala Pro Glu Asn  Lys Ala Phe Val Leu  Ser Ser Val 
    1430                 1435                 1440             


Asp Glu  Leu Glu Gln Gln Arg  Asp Glu Ile Val Ser  Tyr Leu Cys 
    1445                 1450                 1455             


Asp Leu  Ala Pro Glu Ala Pro  Pro Pro Thr Leu Pro  Pro His Met 
    1460                 1465                 1470             


Ala Gln  Val Thr Val Gly Pro  Gly Asp Lys Thr His  Thr Cys Pro 
    1475                 1480                 1485             


Pro Cys  Pro Ala Pro Glu Leu  Leu Gly Gly Pro Ser  Val Phe Leu 
    1490                 1495                 1500             


Phe Pro  Pro Lys Pro Lys Asp  Thr Leu Met Ile Ser  Arg Thr Pro 
    1505                 1510                 1515             


Glu Val  Thr Cys Val Val Val  Asp Val Ser His Glu  Asp Pro Glu 
    1520                 1525                 1530             


Val Lys  Phe Asn Trp Tyr Val  Asp Gly Val Glu Val  His Asn Ala 
    1535                 1540                 1545             


Lys Thr  Lys Pro Arg Glu Glu  Gln Tyr Asn Ser Thr  Tyr Arg Val 
    1550                 1555                 1560             


Val Ser  Val Leu Thr Val Leu  His Gln Asp Trp Leu  Asn Gly Lys 
    1565                 1570                 1575             


Glu Tyr  Lys Cys Lys Val Ser  Asn Lys Ala Leu Pro  Ala Pro Ile 
    1580                 1585                 1590             


Glu Lys  Thr Ile Ser Lys Ala  Lys Gly Gln Pro Arg  Glu Pro Gln 
    1595                 1600                 1605             


Val Tyr  Thr Leu Pro Pro Ser  Arg Asp Glu Leu Thr  Lys Asn Gln 
    1610                 1615                 1620             


Val Ser  Leu Thr Cys Leu Val  Lys Gly Phe Tyr Pro  Ser Asp Ile 
    1625                 1630                 1635             


Ala Val  Glu Trp Glu Ser Asn  Gly Gln Pro Glu Asn  Asn Tyr Lys 
    1640                 1645                 1650             


Thr Thr  Pro Pro Val Leu Asp  Ser Asp Gly Ser Phe  Phe Leu Tyr 
    1655                 1660                 1665             


Ser Lys  Leu Thr Val Asp Lys  Ser Arg Trp Gln Gln  Gly Asn Val 
    1670                 1675                 1680             


Phe Ser  Cys Ser Val Met His  Glu Ala Leu His Asn  His Tyr Thr 
    1685                 1690                 1695             


Gln Lys  Ser Leu Ser Leu Ser  Pro Gly Lys 
    1700                 1705             


<210>  22
<211>  2106
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  sequence

<400>  22

Met Ile Pro Ala Arg Phe Ala Gly Val Leu Leu Ala Leu Ala Leu Ile 
1               5                   10                  15      


Leu Pro Gly Thr Leu Cys Ala Glu Gly Thr Arg Gly Arg Ser Ser Thr 
            20                  25                  30          


Ala Arg Cys Ser Leu Phe Gly Ser Asp Phe Val Asn Thr Phe Asp Gly 
        35                  40                  45              


Ser Met Tyr Ser Phe Ala Gly Tyr Cys Ser Tyr Leu Leu Ala Gly Gly 
    50                  55                  60                  


Cys Gln Lys Arg Ser Phe Ser Ile Ile Gly Asp Phe Gln Asn Gly Lys 
65                  70                  75                  80  


Arg Val Ser Leu Ser Val Tyr Leu Gly Glu Phe Phe Asp Ile His Leu 
                85                  90                  95      


Phe Val Asn Gly Thr Val Thr Gln Gly Asp Gln Arg Val Ser Met Pro 
            100                 105                 110         


Tyr Ala Ser Lys Gly Leu Tyr Leu Glu Thr Glu Ala Gly Tyr Tyr Lys 
        115                 120                 125             


Leu Ser Gly Glu Ala Tyr Gly Phe Val Ala Arg Ile Asp Gly Ser Gly 
    130                 135                 140                 


Asn Phe Gln Val Leu Leu Ser Asp Arg Tyr Phe Asn Lys Thr Cys Gly 
145                 150                 155                 160 


Leu Cys Gly Asn Phe Asn Ile Phe Ala Glu Asp Asp Phe Met Thr Gln 
                165                 170                 175     


Glu Gly Thr Leu Thr Ser Asp Pro Tyr Asp Phe Ala Asn Ser Trp Ala 
            180                 185                 190         


Leu Ser Ser Gly Glu Gln Trp Cys Glu Arg Ala Ser Pro Pro Ser Ser 
        195                 200                 205             


Ser Cys Asn Ile Ser Ser Gly Glu Met Gln Lys Gly Leu Trp Glu Gln 
    210                 215                 220                 


Cys Gln Leu Leu Lys Ser Thr Ser Val Phe Ala Arg Cys His Pro Leu 
225                 230                 235                 240 


Val Asp Pro Glu Pro Phe Val Ala Leu Cys Glu Lys Thr Leu Cys Glu 
                245                 250                 255     


Cys Ala Gly Gly Leu Glu Cys Ala Cys Pro Ala Leu Leu Glu Tyr Ala 
            260                 265                 270         


Arg Thr Cys Ala Gln Glu Gly Met Val Leu Tyr Gly Trp Thr Asp His 
        275                 280                 285             


Ser Ala Cys Ser Pro Val Cys Pro Ala Gly Met Glu Tyr Arg Gln Cys 
    290                 295                 300                 


Val Ser Pro Cys Ala Arg Thr Cys Gln Ser Leu His Ile Asn Glu Met 
305                 310                 315                 320 


Cys Gln Glu Arg Cys Val Asp Gly Cys Ser Cys Pro Glu Gly Gln Leu 
                325                 330                 335     


Leu Asp Glu Gly Leu Cys Val Glu Ser Thr Glu Cys Pro Cys Val His 
            340                 345                 350         


Ser Gly Lys Arg Tyr Pro Pro Gly Thr Ser Leu Ser Arg Asp Cys Asn 
        355                 360                 365             


Thr Cys Ile Cys Arg Asn Ser Gln Trp Ile Cys Ser Asn Glu Glu Cys 
    370                 375                 380                 


Pro Gly Glu Cys Leu Val Thr Gly Gln Ser His Phe Lys Ser Phe Asp 
385                 390                 395                 400 


Asn Arg Tyr Phe Thr Phe Ser Gly Ile Cys Gln Tyr Leu Leu Ala Arg 
                405                 410                 415     


Asp Cys Gln Asp His Ser Phe Ser Ile Val Ile Glu Thr Val Gln Cys 
            420                 425                 430         


Ala Asp Asp Arg Asp Ala Val Cys Thr Arg Ser Val Thr Val Arg Leu 
        435                 440                 445             


Pro Gly Leu His Asn Ser Leu Val Lys Leu Lys His Gly Ala Gly Val 
    450                 455                 460                 


Ala Met Asp Gly Gln Asp Ile Gln Leu Pro Leu Leu Lys Gly Asp Leu 
465                 470                 475                 480 


Arg Ile Gln His Thr Val Thr Ala Ser Val Arg Leu Ser Tyr Gly Glu 
                485                 490                 495     


Asp Leu Gln Met Asp Trp Asp Gly Arg Gly Arg Leu Leu Val Lys Leu 
            500                 505                 510         


Ser Pro Val Tyr Ala Gly Lys Thr Cys Gly Leu Cys Gly Asn Tyr Asn 
        515                 520                 525             


Gly Asn Gln Gly Asp Asp Phe Leu Thr Pro Ser Gly Leu Ala Glu Pro 
    530                 535                 540                 


Arg Val Glu Asp Phe Gly Asn Ala Trp Lys Leu His Gly Asp Cys Gln 
545                 550                 555                 560 


Asp Leu Gln Lys Gln His Ser Asp Pro Cys Ala Leu Asn Pro Arg Met 
                565                 570                 575     


Thr Arg Phe Ser Glu Glu Ala Cys Ala Val Leu Thr Ser Pro Thr Phe 
            580                 585                 590         


Glu Ala Cys His Arg Ala Val Ser Pro Leu Pro Tyr Leu Arg Asn Cys 
        595                 600                 605             


Arg Tyr Asp Val Cys Ser Cys Ser Asp Gly Arg Glu Cys Leu Cys Gly 
    610                 615                 620                 


Ala Leu Ala Ser Tyr Ala Ala Ala Cys Ala Gly Arg Gly Val Arg Val 
625                 630                 635                 640 


Ala Trp Arg Glu Pro Gly Arg Cys Glu Leu Asn Cys Pro Lys Gly Gln 
                645                 650                 655     


Val Tyr Leu Gln Cys Gly Thr Pro Cys Asn Leu Thr Cys Arg Ser Leu 
            660                 665                 670         


Ser Tyr Pro Asp Glu Glu Cys Asn Glu Ala Cys Leu Glu Gly Cys Phe 
        675                 680                 685             


Cys Pro Pro Gly Leu Tyr Met Asp Glu Arg Gly Asp Cys Val Pro Lys 
    690                 695                 700                 


Ala Gln Cys Pro Cys Tyr Tyr Asp Gly Glu Ile Phe Gln Pro Glu Asp 
705                 710                 715                 720 


Ile Phe Ser Asp His His Thr Met Cys Tyr Cys Glu Asp Gly Phe Met 
                725                 730                 735     


His Cys Thr Met Ser Gly Val Pro Gly Ser Leu Leu Pro Asp Ala Val 
            740                 745                 750         


Leu Ser Ser Pro Leu Ser His Arg Ser Lys Arg Ser Leu Ser Cys Arg 
        755                 760                 765             


Pro Pro Met Val Lys Leu Val Cys Pro Ala Asp Asn Leu Arg Ala Glu 
    770                 775                 780                 


Gly Leu Glu Cys Thr Lys Thr Cys Gln Asn Tyr Asp Leu Glu Cys Met 
785                 790                 795                 800 


Ser Met Gly Cys Val Ser Gly Cys Leu Cys Pro Pro Gly Met Val Arg 
                805                 810                 815     


His Glu Asn Arg Cys Val Ala Leu Glu Arg Cys Pro Cys Phe His Gln 
            820                 825                 830         


Gly Lys Glu Tyr Ala Pro Gly Glu Thr Val Lys Ile Gly Cys Asn Thr 
        835                 840                 845             


Cys Val Cys Arg Asp Arg Lys Trp Asn Cys Thr Asp His Val Cys Asp 
    850                 855                 860                 


Ala Thr Cys Ser Thr Ile Gly Met Ala His Tyr Leu Thr Phe Asp Gly 
865                 870                 875                 880 


Leu Lys Tyr Leu Phe Pro Gly Glu Cys Gln Tyr Val Leu Val Gln Asp 
                885                 890                 895     


Tyr Cys Gly Ser Asn Pro Gly Thr Phe Arg Ile Leu Val Gly Asn Lys 
            900                 905                 910         


Gly Cys Ser His Pro Ser Val Lys Cys Lys Lys Arg Val Thr Ile Leu 
        915                 920                 925             


Val Glu Gly Gly Glu Ile Glu Leu Phe Asp Gly Glu Val Asn Val Lys 
    930                 935                 940                 


Arg Pro Met Lys Asp Glu Thr His Phe Glu Val Val Glu Ser Gly Arg 
945                 950                 955                 960 


Tyr Ile Ile Leu Leu Leu Gly Lys Ala Leu Ser Val Val Trp Asp Arg 
                965                 970                 975     


His Leu Ser Ile Ser Val Val Leu Lys Gln Thr Tyr Gln Glu Lys Val 
            980                 985                 990         


Cys Gly Leu Cys Gly Asn Phe Asp  Gly Ile Gln Asn Asn  Asp Leu Thr 
        995                 1000                 1005             


Ser Ser  Asn Leu Gln Val Glu  Glu Asp Pro Val Asp  Phe Gly Asn 
    1010                 1015                 1020             


Ser Trp  Lys Val Ser Ser Gln  Cys Ala Asp Thr Arg  Lys Val Pro 
    1025                 1030                 1035             


Leu Asp  Ser Ser Pro Ala Thr  Cys His Asn Asn Ile  Met Lys Gln 
    1040                 1045                 1050             


Thr Met  Val Asp Ser Ser Cys  Arg Ile Leu Thr Ser  Asp Val Phe 
    1055                 1060                 1065             


Gln Asp  Cys Asn Lys Leu Val  Asp Pro Glu Pro Tyr  Leu Asp Val 
    1070                 1075                 1080             


Cys Ile  Tyr Asp Thr Cys Ser  Cys Glu Ser Ile Gly  Asp Cys Ala 
    1085                 1090                 1095             


Cys Phe  Cys Asp Thr Ile Ala  Ala Tyr Ala His Val  Cys Ala Gln 
    1100                 1105                 1110             


His Gly  Lys Val Val Thr Trp  Arg Thr Ala Thr Leu  Cys Pro Gln 
    1115                 1120                 1125             


Ser Cys  Glu Glu Arg Asn Leu  Arg Glu Asn Gly Tyr  Glu Cys Glu 
    1130                 1135                 1140             


Trp Arg  Tyr Asn Ser Cys Ala  Pro Ala Cys Gln Val  Thr Cys Gln 
    1145                 1150                 1155             


His Pro  Glu Pro Leu Ala Cys  Pro Val Gln Cys Val  Glu Gly Cys 
    1160                 1165                 1170             


His Ala  His Cys Pro Pro Gly  Lys Ile Leu Asp Glu  Leu Leu Gln 
    1175                 1180                 1185             


Thr Cys  Val Asp Pro Glu Asp  Cys Pro Val Cys Glu  Val Ala Gly 
    1190                 1195                 1200             


Arg Arg  Phe Ala Ser Gly Lys  Lys Val Thr Leu Asn  Pro Ser Asp 
    1205                 1210                 1215             


Pro Glu  His Cys Gln Ile Cys  His Cys Asp Val Val  Asn Leu Thr 
    1220                 1225                 1230             


Cys Glu  Ala Cys Gln Glu Pro  Gly Gly Leu Val Val  Pro Pro Thr 
    1235                 1240                 1245             


Asp Ala  Pro Val Ser Pro Thr  Thr Leu Tyr Val Glu  Asp Ile Ser 
    1250                 1255                 1260             


Glu Pro  Pro Leu His Asp Phe  Tyr Cys Ser Arg Leu  Leu Asp Leu 
    1265                 1270                 1275             


Val Phe  Leu Leu Asp Gly Ser  Ser Arg Leu Ser Glu  Ala Glu Phe 
    1280                 1285                 1290             


Glu Val  Leu Lys Ala Phe Val  Val Asp Met Met Glu  Arg Leu Arg 
    1295                 1300                 1305             


Ile Ser  Gln Lys Trp Val Arg  Val Ala Val Val Glu  Tyr His Asp 
    1310                 1315                 1320             


Gly Ser  His Ala Tyr Ile Gly  Leu Lys Asp Arg Lys  Arg Pro Ser 
    1325                 1330                 1335             


Glu Leu  Arg Arg Ile Ala Ser  Gln Val Lys Tyr Ala  Gly Ser Gln 
    1340                 1345                 1350             


Val Ala  Ser Thr Ser Glu Val  Leu Lys Tyr Thr Leu  Phe Gln Ile 
    1355                 1360                 1365             


Phe Ser  Lys Ile Asp Arg Pro  Glu Ala Ser Arg Ile  Ala Leu Leu 
    1370                 1375                 1380             


Leu Met  Ala Ser Gln Glu Pro  Gln Arg Met Ser Arg  Asn Phe Val 
    1385                 1390                 1395             


Arg Tyr  Val Gln Gly Leu Lys  Lys Lys Lys Val Ile  Val Ile Pro 
    1400                 1405                 1410             


Val Gly  Ile Gly Pro His Ala  Asn Leu Lys Gln Ile  Arg Leu Ile 
    1415                 1420                 1425             


Glu Lys  Gln Ala Pro Glu Asn  Lys Ala Phe Val Leu  Ser Ser Val 
    1430                 1435                 1440             


Asp Glu  Leu Glu Gln Gln Arg  Asp Glu Ile Val Ser  Tyr Leu Cys 
    1445                 1450                 1455             


Asp Leu  Ala Pro Glu Ala Pro  Pro Pro Thr Leu Pro  Pro His Met 
    1460                 1465                 1470             


Ala Gln  Val Thr Val Gly Pro  Gly Leu Leu Gly Val  Ser Thr Leu 
    1475                 1480                 1485             


Gly Pro  Lys Arg Asn Ser Met  Val Leu Asp Val Ala  Phe Val Leu 
    1490                 1495                 1500             


Glu Gly  Ser Asp Lys Ile Gly  Glu Ala Asp Phe Asn  Arg Ser Lys 
    1505                 1510                 1515             


Glu Phe  Met Glu Glu Val Ile  Gln Arg Met Asp Val  Gly Gln Asp 
    1520                 1525                 1530             


Ser Ile  His Val Thr Val Leu  Gln Tyr Ser Tyr Met  Val Thr Val 
    1535                 1540                 1545             


Glu Tyr  Pro Phe Ser Glu Ala  Gln Ser Lys Gly Asp  Ile Leu Gln 
    1550                 1555                 1560             


Arg Val  Arg Glu Ile Arg Tyr  Gln Gly Gly Asn Arg  Thr Asn Thr 
    1565                 1570                 1575             


Gly Leu  Ala Leu Arg Tyr Leu  Ser Asp His Ser Phe  Leu Val Ser 
    1580                 1585                 1590             


Gln Gly  Asp Arg Glu Gln Ala  Pro Asn Leu Val Tyr  Met Val Thr 
    1595                 1600                 1605             


Gly Asn  Pro Ala Ser Asp Glu  Ile Lys Arg Leu Pro  Gly Asp Ile 
    1610                 1615                 1620             


Gln Val  Val Pro Ile Gly Val  Gly Pro Asn Ala Asn  Val Gln Glu 
    1625                 1630                 1635             


Leu Glu  Arg Ile Gly Trp Pro  Asn Ala Pro Ile Leu  Ile Gln Asp 
    1640                 1645                 1650             


Phe Glu  Thr Leu Pro Arg Glu  Ala Pro Asp Leu Val  Leu Gln Arg 
    1655                 1660                 1665             


Cys Cys  Ser Gly Glu Gly Leu  Gln Ile Pro Thr Leu  Ser Pro Ala 
    1670                 1675                 1680             


Pro Asp  Cys Ser Gln Pro Leu  Asp Val Ile Leu Leu  Leu Asp Gly 
    1685                 1690                 1695             


Ser Ser  Ser Phe Pro Ala Ser  Tyr Phe Asp Glu Met  Lys Ser Phe 
    1700                 1705                 1710             


Ala Lys  Ala Phe Ile Ser Lys  Ala Asn Ile Gly Pro  Arg Leu Thr 
    1715                 1720                 1725             


Gln Val  Ser Val Leu Gln Tyr  Gly Ser Ile Thr Thr  Ile Asp Val 
    1730                 1735                 1740             


Pro Trp  Asn Val Val Pro Glu  Lys Ala His Leu Leu  Ser Leu Val 
    1745                 1750                 1755             


Asp Val  Met Gln Arg Glu Gly  Gly Pro Ser Gln Ile  Gly Asp Ala 
    1760                 1765                 1770             


Leu Gly  Phe Ala Val Arg Tyr  Leu Thr Ser Glu Met  His Gly Ala 
    1775                 1780                 1785             


Arg Pro  Gly Ala Ser Lys Ala  Val Val Ile Leu Val  Thr Asp Val 
    1790                 1795                 1800             


Ser Val  Asp Ser Val Asp Ala  Ala Ala Asp Ala Ala  Arg Ser Asn 
    1805                 1810                 1815             


Arg Val  Thr Val Phe Pro Ile  Gly Ile Gly Asp Arg  Tyr Asp Ala 
    1820                 1825                 1830             


Ala Gln  Leu Arg Ile Leu Ala  Gly Pro Ala Gly Asp  Ser Asn Val 
    1835                 1840                 1845             


Val Lys  Leu Gln Arg Ile Glu  Asp Leu Pro Thr Met  Val Thr Leu 
    1850                 1855                 1860             


Gly Asn  Ser Phe Leu His Lys  Leu Cys Ser Gly Phe  Val Arg Ile 
    1865                 1870                 1875             


Cys Asp  Lys Thr His Thr Cys  Pro Pro Cys Pro Ala  Pro Glu Leu 
    1880                 1885                 1890             


Leu Gly  Gly Pro Ser Val Phe  Leu Phe Pro Pro Lys  Pro Lys Asp 
    1895                 1900                 1905             


Thr Leu  Met Ile Ser Arg Thr  Pro Glu Val Thr Cys  Val Val Val 
    1910                 1915                 1920             


Asp Val  Ser His Glu Asp Pro  Glu Val Lys Phe Asn  Trp Tyr Val 
    1925                 1930                 1935             


Asp Gly  Val Glu Val His Asn  Ala Lys Thr Lys Pro  Arg Glu Glu 
    1940                 1945                 1950             


Gln Tyr  Asn Ser Thr Tyr Arg  Val Val Ser Val Leu  Thr Val Leu 
    1955                 1960                 1965             


His Gln  Asp Trp Leu Asn Gly  Lys Glu Tyr Lys Cys  Lys Val Ser 
    1970                 1975                 1980             


Asn Lys  Ala Leu Pro Ala Pro  Ile Glu Lys Thr Ile  Ser Lys Ala 
    1985                 1990                 1995             


Lys Gly  Gln Pro Arg Glu Pro  Gln Val Tyr Thr Leu  Pro Pro Ser 
    2000                 2005                 2010             


Arg Asp  Glu Leu Thr Lys Asn  Gln Val Ser Leu Thr  Cys Leu Val 
    2015                 2020                 2025             


Lys Gly  Phe Tyr Pro Ser Asp  Ile Ala Val Glu Trp  Glu Ser Asn 
    2030                 2035                 2040             


Gly Gln  Pro Glu Asn Asn Tyr  Lys Thr Thr Pro Pro  Val Leu Asp 
    2045                 2050                 2055             


Ser Asp  Gly Ser Phe Phe Leu  Tyr Ser Lys Leu Thr  Val Asp Lys 
    2060                 2065                 2070             


Ser Arg  Trp Gln Gln Gly Asn  Val Phe Ser Cys Ser  Val Met His 
    2075                 2080                 2085             


Glu Ala  Leu His Asn His Tyr  Thr Gln Lys Ser Leu  Ser Leu Ser 
    2090                 2095                 2100             


Pro Gly  Lys 
    2105     


<210>  23
<211>  6318
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  sequence

<400>  23
atgatccccg ccagattcgc cggcgtgctg ctggccctgg ccctgatcct gcccggcacc       60

ctgtgcgccg agggcaccag aggcagatcc agcaccgccc ggtgcagcct gttcggcagc      120

gacttcgtga acaccttcga cggcagcatg tacagcttcg ccggctactg tagctacctg      180

ctggctggcg gctgccagaa gcggagcttc agcatcatcg gcgacttcca gaacggcaag      240

cgggtgtccc tgagcgtgta cctgggcgag ttcttcgaca tccacctgtt cgtgaacggc      300

accgtgaccc agggcgatca gagggtgtcc atgccctacg ccagcaaggg cctgtacctg      360

gaaaccgagg ccggctacta caagctgtcc ggcgaggcct acggcttcgt ggcccggatc      420

gacggctccg gcaacttcca ggtgctgctg tccgaccggt acttcaacaa gacctgcggc      480

ctgtgcggca acttcaacat cttcgccgag gacgacttca tgacccagga aggcaccctg      540

accagcgacc cctacgactt cgccaacagc tgggccctga gcagcggcga gcagtggtgc      600

gagagagcca gcccccccag cagcagctgc aacatcagct ccggcgagat gcagaaaggc      660

ctgtgggagc agtgccagct gctgaagtcc acctccgtgt tcgcccggtg ccaccccctg      720

gtggaccccg agccctttgt ggccctgtgc gaaaagaccc tgtgcgagtg cgctggcggc      780

ctggaatgcg cctgccctgc cctgctggaa tacgcccgga cctgcgccca agaagggatg      840

gtcctgtacg gctggaccga ccacagcgcc tgcagccccg tctgccctgc cggcatggaa      900

taccggcagt gcgtgagccc ctgcgccaga acctgccaga gcctgcacat caacgagatg      960

tgccaggaaa gatgcgtcga cggctgctct tgtcccgagg gacagctcct ggacgagggc     1020

ctctgcgtgg agagcaccga gtgcccctgc gtgcacagcg gcaagagata cccccctggc     1080

accagcctga gccgggactg caacacctgc atttgccgga acagccagtg gatctgcagc     1140

aacgaggaat gcccaggcga gtgcctggtc accggccaga gccacttcaa gagcttcgac     1200

aacagatact tcaccttcag cggcatctgc cagtatctgc tggccagaga ctgccaggac     1260

cacagcttct ccatcgtgat cgagacagtg cagtgcgccg acgaccggga cgccgtgtgc     1320

accagatccg tgaccgtgag actgcccggc ctgcacaaca gcctggtcaa gctgaagcat     1380

ggcgctggcg tggccatgga cggccaggac atccagctgc ctctgctgaa gggcgacctg     1440

cggatccagc acaccgtgac cgccagcgtg agactgtcct acggcgagga cctgcagatg     1500

gactgggacg gcagaggccg gctgctcgtg aagctgtccc ccgtgtacgc cggcaagaca     1560

tgtggcctgt gtgggaacta caacggcaac cagggcgacg actttctgac ccccagcggc     1620

ctggccgagc ccagagtgga ggacttcggc aacgcctgga agctgcacgg cgattgccag     1680

gatctgcaga aacagcactc cgacccctgc gccctgaacc cccggatgac ccggttcagc     1740

gaagaggctt gcgccgtgct gaccagcccc accttcgagg cctgccaccg ggccgtgagc     1800

cccctgccct acctgcggaa ctgcagatac gatgtgtgta gctgctctga cggccgggag     1860

tgcctgtgtg gcgccctggc cagctatgcc gctgcctgcg ccggacgcgg tgtgagagtg     1920

gcttggcggg agcctggcag atgcgagctg aactgcccca agggccaggt gtacctgcag     1980

tgcggcaccc cctgcaacct gacctgccgg tccctgagct accccgacga agagtgcaac     2040

gaggcctgtc tcgaaggctg cttctgcccc cctggcctgt acatggacga gcggggcgac     2100

tgcgtgccca aggcccagtg cccctgttac tacgacggcg agatcttcca gcccgaggac     2160

atcttcagcg accaccacac catgtgctac tgcgaggacg gctttatgca ctgcaccatg     2220

agcggcgtgc ccggcagcct gctgccagac gccgtgctgt cctcccccct gagccaccgg     2280

tccaagcgga gcctgagctg cagacccccc atggtcaagc tcgtgtgccc agccgacaat     2340

ctgcgggccg aggggctgga atgcaccaag acctgccaga actacgacct ggaatgcatg     2400

agcatgggct gcgtgagcgg ctgcctgtgc ccacccggca tggtccggca cgagaacaga     2460

tgcgtggccc tggaacggtg cccatgcttc caccagggca aagagtacgc ccctggcgag     2520

acagtgaaga tcggctgcaa tacctgcgtg tgccgggacc ggaagtggaa ctgcaccgac     2580

cacgtgtgcg acgccacatg cagcaccatc ggcatggccc actacctgac ctttgacggc     2640

ctgaagtacc tgttccccgg cgagtgccag tacgtgctgg tgcaggacta ctgcggcagc     2700

aaccccggca ccttccggat cctcgtgggc aacaagggat gcagccaccc cagcgtgaag     2760

tgcaagaaac gcgtgaccat cctggtggag ggcggcgaga tcgagctgtt cgacggcgaa     2820

gtgaacgtga agcggcccat gaaggacgag acacacttcg aggtggtgga gagcggccgg     2880

tacatcatcc tgctgctggg caaggctctg agcgtcgtgt gggaccggca cctgagcatc     2940

agcgtggtgc tgaagcagac ctaccaggaa aaagtctgcg gcctctgtgg caatttcgac     3000

ggcatccaga acaacgatct gaccagcagc aacctgcagg tggaagagga ccccgtggac     3060

tttggcaata gctggaaggt gtccagccag tgtgccgaca ccagaaaagt gcccctggac     3120

tctagccccg ccacctgcca caacaacatc atgaagcaga caatggtgga cagctcctgc     3180

cggatcctga cctccgacgt gttccaggac tgtaacaaac tggtggatcc tgagccttac     3240

ctggacgtgt gcatctacga cacctgcagc tgcgagagca tcggcgattg cgcctgcttc     3300

tgcgacacaa tcgccgccta cgcccatgtg tgcgcccagc acggcaaggt ggtcacctgg     3360

cggaccgcaa ccctgtgccc ccagagctgc gaggaacgga acctgcggga gaacggctac     3420

gagtgcgagt ggcggtacaa cagctgcgcc ccagcctgcc aggtcacctg ccagcacccc     3480

gagcctctgg cctgccccgt gcagtgcgtg gagggctgcc acgcccactg ccctccaggc     3540

aagatcctgg acgagctgct gcagacctgc gtggaccctg aggactgccc tgtgtgcgag     3600

gtggccggca ggcggttcgc ctccggcaag aaagtgaccc tgaaccctag cgaccccgag     3660

cactgccaga tctgccactg cgacgtggtc aatctgacct gcgaggcttg ccaggaacca     3720

ggcggcctcg tcgtgccccc taccgacgcc cctgtgtccc caaccaccct gtacgtggag     3780

gacatcagcg agccccccct gcacgacttc tactgctctc ggctgctgga cctggtgttc     3840

ctgctggacg gcagttctag actgagcgag gccgagttcg aggtgctgaa ggccttcgtc     3900

gtggacatga tggaacggct gcggatcagc cagaaatggg tccgggtggc cgtggtggag     3960

taccacgacg gcagccacgc ctacatcggc ctgaaggacc ggaagcggcc ctccgaactc     4020

cggcggatcg ccagccaggt caagtacgcc ggatcccagg tggccagcac cagcgaagtg     4080

ctgaagtaca ccctgttcca gatcttcagc aagatcgacc ggcccgaggc cagccggatc     4140

gcactgctgc tgatggccag ccaagaaccc cagcggatga gccggaactt cgtgagatac     4200

gtgcagggcc tgaagaaaaa gaaagtgatc gtgatccccg tgggcatcgg cccccacgcc     4260

aacctgaagc agatccggct gatcgagaag caggcacccg agaacaaggc ctttgtgctg     4320

tccagcgtgg atgagctgga acagcagcgg gacgagatcg tgtcctacct gtgcgacctg     4380

gcccctgagg cccctcctcc cacactgccc ccccacatgg ctcaggtcac cgtgggacca     4440

ggcctgctgg gagtgagcac actgggcccc aagcggaaca gcatggtgct ggacgtggcc     4500

ttcgtgctcg agggcagcga caagatcggc gaggccgact tcaaccggtc caaagaattc     4560

atggaagagg tcatccagcg gatggacgtg ggccaggaca gcatccacgt gacagtgctg     4620

cagtacagct acatggtcac agtggagtac cccttcagcg aggcccagag caagggcgac     4680

atcctgcaga gagtgcggga gatcagatac cagggcggca accggaccaa caccggcctg     4740

gccctgcgct acctgagcga ccactccttt ctggtgtctc agggcgatcg ggagcaggcc     4800

cctaacctgg tgtatatggt cacaggcaac cccgctagcg acgagatcaa gagactgccc     4860

ggcgacatcc aggtggtgcc catcggcgtg ggccccaacg ctaatgtgca ggaactggaa     4920

cggatcggct ggcccaacgc ccccatcctg atccaggact tcgagacact gcccagagaa     4980

gcccccgacc tggtgctgca gcggtgctgt agcggcgagg ggctgcagat ccccaccctg     5040

agccctgccc ccgactgcag ccagcccctg gacgtgatcc tgctcctgga cggctccagc     5100

tccttccccg ccagctactt cgacgagatg aagtccttcg ccaaggcctt catcagcaag     5160

gccaacatcg gccccagact gacccaggtg tccgtgctcc agtacggcag catcaccacc     5220

atcgacgtgc cctggaatgt ggtccccgag aaggcccacc tgctgtccct ggtggatgtg     5280

atgcagcggg agggcggacc cagccagatc ggcgacgccc tgggcttcgc cgtgagatac     5340

ctgacaagcg agatgcacgg agccagacct ggagcctcca aggccgtggt catcctcgtg     5400

accgacgtgt ccgtggacag cgtggacgct gccgccgacg ccgccagatc caacagagtg     5460

accgtgttcc ctatcggcat cggcgaccgc tacgacgccg cccagctgag aatcctggcc     5520

ggacctgccg gcgacagcaa cgtggtcaaa ctgcagcgga tcgaggatct gcccaccatg     5580

gtcaccctgg gcaacagctt tctgcacaag ctgtgtagcg gcttcgtgcg gatctgcgac     5640

aaaactcaca catgcccacc gtgcccagca cctgaactcc tggggggacc gtcagtcttc     5700

ctcttccccc caaaacccaa ggacaccctc atgatctccc ggacccctga ggtcacatgc     5760

gtggtggtgg acgtgagcca cgaagaccct gaggtcaagt tcaactggta cgtggacggc     5820

gtggaggtgc ataatgccaa gacaaagccg cgggaggagc agtacaacag cacgtaccgt     5880

gtggtcagcg tcctcaccgt cctgcaccag gactggctga atggcaagga gtacaagtgc     5940

aaggtctcca acaaagccct cccagccccc atcgagaaaa ccatctccaa agccaaaggg     6000

cagccccgag agccacaggt gtacaccctg cccccatccc gggatgagct gaccaagaac     6060

caggtcagcc tgacctgcct ggtcaaaggc ttctatccca gcgacatcgc cgtggagtgg     6120

gagagcaatg ggcagccgga gaacaactac aagaccacgc ctcccgtgct ggactccgac     6180

ggctccttct tcctctacag caagctcacc gtggacaaga gcaggtggca gcaggggaac     6240

gtcttctcat gctccgtgat gcatgaggct ctgcacaacc actacacgca gaagagcctc     6300

tccctgtctc cgggtaaa                                                   6318


<210>  24
<211>  4422
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  sequence

<400>  24
atgatccccg ccagattcgc cggcgtgctg ctggccctgg ccctgatcct gcccggcacc       60

ctgtgcgccg agggcaccag aggcagatcc agcaccgccc ggtgcagcct gttcggcagc      120

gacttcgtga acaccttcga cggcagcatg tacagcttcg ccggctactg tagctacctg      180

ctggctggcg gctgccagaa gcggagcttc agcatcatcg gcgacttcca gaacggcaag      240

cgggtgtccc tgagcgtgta cctgggcgag ttcttcgaca tccacctgtt cgtgaacggc      300

accgtgaccc agggcgatca gagggtgtcc atgccctacg ccagcaaggg cctgtacctg      360

gaaaccgagg ccggctacta caagctgtcc ggcgaggcct acggcttcgt ggcccggatc      420

gacggctccg gcaacttcca ggtgctgctg tccgaccggt acttcaacaa gacctgcggc      480

ctgtgcggca acttcaacat cttcgccgag gacgacttca tgacccagga aggcaccctg      540

accagcgacc cctacgactt cgccaacagc tgggccctga gcagcggcga gcagtggtgc      600

gagagagcca gcccccccag cagcagctgc aacatcagct ccggcgagat gcagaaaggc      660

ctgtgggagc agtgccagct gctgaagtcc acctccgtgt tcgcccggtg ccaccccctg      720

gtggaccccg agccctttgt ggccctgtgc gaaaagaccc tgtgcgagtg cgctggcggc      780

ctggaatgcg cctgccctgc cctgctggaa tacgcccgga cctgcgccca agaagggatg      840

gtcctgtacg gctggaccga ccacagcgcc tgcagccccg tctgccctgc cggcatggaa      900

taccggcagt gcgtgagccc ctgcgccaga acctgccaga gcctgcacat caacgagatg      960

tgccaggaaa gatgcgtcga cggctgctct tgtcccgagg gacagctcct ggacgagggc     1020

ctctgcgtgg agagcaccga gtgcccctgc gtgcacagcg gcaagagata cccccctggc     1080

accagcctga gccgggactg caacacctgc atttgccgga acagccagtg gatctgcagc     1140

aacgaggaat gcccaggcga gtgcctggtc accggccaga gccacttcaa gagcttcgac     1200

aacagatact tcaccttcag cggcatctgc cagtatctgc tggccagaga ctgccaggac     1260

cacagcttct ccatcgtgat cgagacagtg cagtgcgccg acgaccggga cgccgtgtgc     1320

accagatccg tgaccgtgag actgcccggc ctgcacaaca gcctggtcaa gctgaagcat     1380

ggcgctggcg tggccatgga cggccaggac atccagctgc ctctgctgaa gggcgacctg     1440

cggatccagc acaccgtgac cgccagcgtg agactgtcct acggcgagga cctgcagatg     1500

gactgggacg gcagaggccg gctgctcgtg aagctgtccc ccgtgtacgc cggcaagaca     1560

tgtggcctgt gtgggaacta caacggcaac cagggcgacg actttctgac ccccagcggc     1620

ctggccgagc ccagagtgga ggacttcggc aacgcctgga agctgcacgg cgattgccag     1680

gatctgcaga aacagcactc cgacccctgc gccctgaacc cccggatgac ccggttcagc     1740

gaagaggctt gcgccgtgct gaccagcccc accttcgagg cctgccaccg ggccgtgagc     1800

cccctgccct acctgcggaa ctgcagatac gatgtgtgta gctgctctga cggccgggag     1860

tgcctgtgtg gcgccctggc cagctatgcc gctgcctgcg ccggacgcgg tgtgagagtg     1920

gcttggcggg agcctggcag atgcgagctg aactgcccca agggccaggt gtacctgcag     1980

tgcggcaccc cctgcaacct gacctgccgg tccctgagct accccgacga agagtgcaac     2040

gaggcctgtc tcgaaggctg cttctgcccc cctggcctgt acatggacga gcggggcgac     2100

tgcgtgccca aggcccagtg cccctgttac tacgacggcg agatcttcca gcccgaggac     2160

atcttcagcg accaccacac catgtgctac tgcgaggacg gctttatgca ctgcaccatg     2220

agcggcgtgc ccggcagcct gctgccagac gccgtgctgt cctcccccct gagccaccgg     2280

tccaagcgga gcctgagctg cagacccccc atggtcaagc tcgtgtgccc agccgacaat     2340

ctgcgggccg aggggctgga atgcaccaag acctgccaga actacgacct ggaatgcatg     2400

agcatgggct gcgtgagcgg ctgcctgtgc ccacccggca tggtccggca cgagaacaga     2460

tgcgtggccc tggaacggtg cccatgcttc caccagggca aagagtacgc ccctggcgag     2520

acagtgaaga tcggctgcaa tacctgcgtg tgccgggacc ggaagtggaa ctgcaccgac     2580

cacgtgtgcg acgccacatg cagcaccatc ggcatggccc actacctgac ctttgacggc     2640

ctgaagtacc tgttccccgg cgagtgccag tacgtgctgg tgcaggacta ctgcggcagc     2700

aaccccggca ccttccggat cctcgtgggc aacaagggat gcagccaccc cagcgtgaag     2760

tgcaagaaac gcgtgaccat cctggtggag ggcggcgaga tcgagctgtt cgacggcgaa     2820

gtgaacgtga agcggcccat gaaggacgag acacacttcg aggtggtgga gagcggccgg     2880

tacatcatcc tgctgctggg caaggctctg agcgtcgtgt gggaccggca cctgagcatc     2940

agcgtggtgc tgaagcagac ctaccaggaa aaagtctgcg gcctctgtgg caatttcgac     3000

ggcatccaga acaacgatct gaccagcagc aacctgcagg tggaagagga ccccgtggac     3060

tttggcaata gctggaaggt gtccagccag tgtgccgaca ccagaaaagt gcccctggac     3120

tctagccccg ccacctgcca caacaacatc atgaagcaga caatggtgga cagctcctgc     3180

cggatcctga cctccgacgt gttccaggac tgtaacaaac tggtggatcc tgagccttac     3240

ctggacgtgt gcatctacga cacctgcagc tgcgagagca tcggcgattg cgcctgcttc     3300

tgcgacacaa tcgccgccta cgcccatgtg tgcgcccagc acggcaaggt ggtcacctgg     3360

cggaccgcaa ccctgtgccc ccagagctgc gaggaacgga acctgcggga gaacggctac     3420

gagtgcgagt ggcggtacaa cagctgcgcc ccagcctgcc aggtcacctg ccagcacccc     3480

gagcctctgg cctgccccgt gcagtgcgtg gagggctgcc acgcccactg ccctccaggc     3540

aagatcctgg acgagctgct gcagacctgc gtggaccctg aggactgccc tgtgtgcgag     3600

gtggccggca ggcggttcgc ctccggcaag aaagtgaccc tgaaccctag cgaccccgag     3660

cactgccaga tctgccactg cgacgtggtc aatctgacct gcgaggcttg ccaggaacca     3720

ggcggcctcg tcgtgccccc tgacaaaact cacacatgcc caccgtgccc agcacctgaa     3780

ctcctggggg gaccgtcagt cttcctcttc cccccaaaac ccaaggacac cctcatgatc     3840

tcccggaccc ctgaggtcac atgcgtggtg gtggacgtga gccacgaaga ccctgaggtc     3900

aagttcaact ggtacgtgga cggcgtggag gtgcataatg ccaagacaaa gccgcgggag     3960

gagcagtaca acagcacgta ccgtgtggtc agcgtcctca ccgtcctgca ccaggactgg     4020

ctgaatggca aggagtacaa gtgcaaggtc tccaacaaag ccctcccagc ccccatcgag     4080

aaaaccatct ccaaagccaa agggcagccc cgagagccac aggtgtacac cctgccccca     4140

tcccgggatg agctgaccaa gaaccaggtc agcctgacct gcctggtcaa aggcttctat     4200

cccagcgaca tcgccgtgga gtgggagagc aatgggcagc cggagaacaa ctacaagacc     4260

acgcctcccg tgctggactc cgacggctcc ttcttcctct acagcaagct caccgtggac     4320

aagagcaggt ggcagcaggg gaacgtcttc tcatgctccg tgatgcatga ggctctgcac     4380

aaccactaca cgcagaagag cctctccctg tctccgggta aa                        4422


<210>  25
<211>  4098
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  sequence

<400>  25
atgatccccg ccagattcgc cggcgtgctg ctggccctgg ccctgatcct gcccggcacc       60

ctgtgcgcca gcctgagctg cagacccccc atggtcaagc tcgtgtgccc agccgacaat      120

ctgcgggccg aggggctgga atgcaccaag acctgccaga actacgacct ggaatgcatg      180

agcatgggct gcgtgagcgg ctgcctgtgc ccacccggca tggtccggca cgagaacaga      240

tgcgtggccc tggaacggtg cccatgcttc caccagggca aagagtacgc ccctggcgag      300

acagtgaaga tcggctgcaa tacctgcgtg tgccgggacc ggaagtggaa ctgcaccgac      360

cacgtgtgcg acgccacatg cagcaccatc ggcatggccc actacctgac ctttgacggc      420

ctgaagtacc tgttccccgg cgagtgccag tacgtgctgg tgcaggacta ctgcggcagc      480

aaccccggca ccttccggat cctcgtgggc aacaagggat gcagccaccc cagcgtgaag      540

tgcaagaaac gcgtgaccat cctggtggag ggcggcgaga tcgagctgtt cgacggcgaa      600

gtgaacgtga agcggcccat gaaggacgag acacacttcg aggtggtgga gagcggccgg      660

tacatcatcc tgctgctggg caaggctctg agcgtcgtgt gggaccggca cctgagcatc      720

agcgtggtgc tgaagcagac ctaccaggaa aaagtctgcg gcctctgtgg caatttcgac      780

ggcatccaga acaacgatct gaccagcagc aacctgcagg tggaagagga ccccgtggac      840

tttggcaata gctggaaggt gtccagccag tgtgccgaca ccagaaaagt gcccctggac      900

tctagccccg ccacctgcca caacaacatc atgaagcaga caatggtgga cagctcctgc      960

cggatcctga cctccgacgt gttccaggac tgtaacaaac tggtggatcc tgagccttac     1020

ctggacgtgt gcatctacga cacctgcagc tgcgagagca tcggcgattg cgcctgcttc     1080

tgcgacacaa tcgccgccta cgcccatgtg tgcgcccagc acggcaaggt ggtcacctgg     1140

cggaccgcaa ccctgtgccc ccagagctgc gaggaacgga acctgcggga gaacggctac     1200

gagtgcgagt ggcggtacaa cagctgcgcc ccagcctgcc aggtcacctg ccagcacccc     1260

gagcctctgg cctgccccgt gcagtgcgtg gagggctgcc acgcccactg ccctccaggc     1320

aagatcctgg acgagctgct gcagacctgc gtggaccctg aggactgccc tgtgtgcgag     1380

gtggccggca ggcggttcgc ctccggcaag aaagtgaccc tgaaccctag cgaccccgag     1440

cactgccaga tctgccactg cgacgtggtc aatctgacct gcgaggcttg ccaggaacca     1500

ggcggcctcg tcgtgccccc taccgacgcc cctgtgtccc caaccaccct gtacgtggag     1560

gacatcagcg agccccccct gcacgacttc tactgctctc ggctgctgga cctggtgttc     1620

ctgctggacg gcagttctag actgagcgag gccgagttcg aggtgctgaa ggccttcgtc     1680

gtggacatga tggaacggct gcggatcagc cagaaatggg tccgggtggc cgtggtggag     1740

taccacgacg gcagccacgc ctacatcggc ctgaaggacc ggaagcggcc ctccgaactc     1800

cggcggatcg ccagccaggt caagtacgcc ggatcccagg tggccagcac cagcgaagtg     1860

ctgaagtaca ccctgttcca gatcttcagc aagatcgacc ggcccgaggc cagccggatc     1920

gcactgctgc tgatggccag ccaagaaccc cagcggatga gccggaactt cgtgagatac     1980

gtgcagggcc tgaagaaaaa gaaagtgatc gtgatccccg tgggcatcgg cccccacgcc     2040

aacctgaagc agatccggct gatcgagaag caggcacccg agaacaaggc ctttgtgctg     2100

tccagcgtgg atgagctgga acagcagcgg gacgagatcg tgtcctacct gtgcgacctg     2160

gcccctgagg cccctcctcc cacactgccc ccccacatgg ctcaggtcac cgtgggacca     2220

ggcctgctgg gagtgagcac actgggcccc aagcggaaca gcatggtgct ggacgtggcc     2280

ttcgtgctcg agggcagcga caagatcggc gaggccgact tcaaccggtc caaagaattc     2340

atggaagagg tcatccagcg gatggacgtg ggccaggaca gcatccacgt gacagtgctg     2400

cagtacagct acatggtcac agtggagtac cccttcagcg aggcccagag caagggcgac     2460

atcctgcaga gagtgcggga gatcagatac cagggcggca accggaccaa caccggcctg     2520

gccctgcgct acctgagcga ccactccttt ctggtgtctc agggcgatcg ggagcaggcc     2580

cctaacctgg tgtatatggt cacaggcaac cccgctagcg acgagatcaa gagactgccc     2640

ggcgacatcc aggtggtgcc catcggcgtg ggccccaacg ctaatgtgca ggaactggaa     2700

cggatcggct ggcccaacgc ccccatcctg atccaggact tcgagacact gcccagagaa     2760

gcccccgacc tggtgctgca gcggtgctgt agcggcgagg ggctgcagat ccccaccctg     2820

agccctgccc ccgactgcag ccagcccctg gacgtgatcc tgctcctgga cggctccagc     2880

tccttccccg ccagctactt cgacgagatg aagtccttcg ccaaggcctt catcagcaag     2940

gccaacatcg gccccagact gacccaggtg tccgtgctcc agtacggcag catcaccacc     3000

atcgacgtgc cctggaatgt ggtccccgag aaggcccacc tgctgtccct ggtggatgtg     3060

atgcagcggg agggcggacc cagccagatc ggcgacgccc tgggcttcgc cgtgagatac     3120

ctgacaagcg agatgcacgg agccagacct ggagcctcca aggccgtggt catcctcgtg     3180

accgacgtgt ccgtggacag cgtggacgct gccgccgacg ccgccagatc caacagagtg     3240

accgtgttcc ctatcggcat cggcgaccgc tacgacgccg cccagctgag aatcctggcc     3300

ggacctgccg gcgacagcaa cgtggtcaaa ctgcagcgga tcgaggatct gcccaccatg     3360

gtcaccctgg gcaacagctt tctgcacaag ctgtgtagcg gcttcgtgcg gatctgcgac     3420

aaaactcaca catgcccacc gtgcccagca cctgaactcc tggggggacc gtcagtcttc     3480

ctcttccccc caaaacccaa ggacaccctc atgatctccc ggacccctga ggtcacatgc     3540

gtggtggtgg acgtgagcca cgaagaccct gaggtcaagt tcaactggta cgtggacggc     3600

gtggaggtgc ataatgccaa gacaaagccg cgggaggagc agtacaacag cacgtaccgt     3660

gtggtcagcg tcctcaccgt cctgcaccag gactggctga atggcaagga gtacaagtgc     3720

aaggtctcca acaaagccct cccagccccc atcgagaaaa ccatctccaa agccaaaggg     3780

cagccccgag agccacaggt gtacaccctg cccccatccc gggatgagct gaccaagaac     3840

caggtcagcc tgacctgcct ggtcaaaggc ttctatccca gcgacatcgc cgtggagtgg     3900

gagagcaatg ggcagccgga gaacaactac aagaccacgc ctcccgtgct ggactccgac     3960

ggctccttct tcctctacag caagctcacc gtggacaaga gcaggtggca gcaggggaac     4020

gtcttctcat gctccgtgat gcatgaggct ctgcacaacc actacacgca gaagagcctc     4080

tccctgtctc cgggtaaa                                                   4098


<210>  26
<211>  2202
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  sequence

<400>  26
atgatccccg ccagattcgc cggcgtgctg ctggccctgg ccctgatcct gcccggcacc       60

ctgtgcgcca gcctgagctg cagacccccc atggtcaagc tcgtgtgccc agccgacaat      120

ctgcgggccg aggggctgga atgcaccaag acctgccaga actacgacct ggaatgcatg      180

agcatgggct gcgtgagcgg ctgcctgtgc ccacccggca tggtccggca cgagaacaga      240

tgcgtggccc tggaacggtg cccatgcttc caccagggca aagagtacgc ccctggcgag      300

acagtgaaga tcggctgcaa tacctgcgtg tgccgggacc ggaagtggaa ctgcaccgac      360

cacgtgtgcg acgccacatg cagcaccatc ggcatggccc actacctgac ctttgacggc      420

ctgaagtacc tgttccccgg cgagtgccag tacgtgctgg tgcaggacta ctgcggcagc      480

aaccccggca ccttccggat cctcgtgggc aacaagggat gcagccaccc cagcgtgaag      540

tgcaagaaac gcgtgaccat cctggtggag ggcggcgaga tcgagctgtt cgacggcgaa      600

gtgaacgtga agcggcccat gaaggacgag acacacttcg aggtggtgga gagcggccgg      660

tacatcatcc tgctgctggg caaggctctg agcgtcgtgt gggaccggca cctgagcatc      720

agcgtggtgc tgaagcagac ctaccaggaa aaagtctgcg gcctctgtgg caatttcgac      780

ggcatccaga acaacgatct gaccagcagc aacctgcagg tggaagagga ccccgtggac      840

tttggcaata gctggaaggt gtccagccag tgtgccgaca ccagaaaagt gcccctggac      900

tctagccccg ccacctgcca caacaacatc atgaagcaga caatggtgga cagctcctgc      960

cggatcctga cctccgacgt gttccaggac tgtaacaaac tggtggatcc tgagccttac     1020

ctggacgtgt gcatctacga cacctgcagc tgcgagagca tcggcgattg cgcctgcttc     1080

tgcgacacaa tcgccgccta cgcccatgtg tgcgcccagc acggcaaggt ggtcacctgg     1140

cggaccgcaa ccctgtgccc ccagagctgc gaggaacgga acctgcggga gaacggctac     1200

gagtgcgagt ggcggtacaa cagctgcgcc ccagcctgcc aggtcacctg ccagcacccc     1260

gagcctctgg cctgccccgt gcagtgcgtg gagggctgcc acgcccactg ccctccaggc     1320

aagatcctgg acgagctgct gcagacctgc gtggaccctg aggactgccc tgtgtgcgag     1380

gtggccggca ggcggttcgc ctccggcaag aaagtgaccc tgaaccctag cgaccccgag     1440

cactgccaga tctgccactg cgacgtggtc aatctgacct gcgaggcttg ccaggaacca     1500

ggcggcctcg tcgtgccccc tgacaaaact cacacatgcc caccgtgccc agcacctgaa     1560

ctcctggggg gaccgtcagt cttcctcttc cccccaaaac ccaaggacac cctcatgatc     1620

tcccggaccc ctgaggtcac atgcgtggtg gtggacgtga gccacgaaga ccctgaggtc     1680

aagttcaact ggtacgtgga cggcgtggag gtgcataatg ccaagacaaa gccgcgggag     1740

gagcagtaca acagcacgta ccgtgtggtc agcgtcctca ccgtcctgca ccaggactgg     1800

ctgaatggca aggagtacaa gtgcaaggtc tccaacaaag ccctcccagc ccccatcgag     1860

aaaaccatct ccaaagccaa agggcagccc cgagagccac aggtgtacac cctgccccca     1920

tcccgggatg agctgaccaa gaaccaggtc agcctgacct gcctggtcaa aggcttctat     1980

cccagcgaca tcgccgtgga gtgggagagc aatgggcagc cggagaacaa ctacaagacc     2040

acgcctcccg tgctggactc cgacggctcc ttcttcctct acagcaagct caccgtggac     2100

aagagcaggt ggcagcaggg gaacgtcttc tcatgctccg tgatgcatga ggctctgcac     2160

aaccactaca cgcagaagag cctctccctg tctccgggta aa                        2202


<210>  27
<211>  2904
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  sequence

<400>  27
atgatccccg ccagattcgc cggcgtgctg ctggccctgg ccctgatcct gcccggcacc       60

ctgtgcgcca gcctgagctg cagacccccc atggtcaagc tcgtgtgccc agccgacaat      120

ctgcgggccg aggggctgga atgcaccaag acctgccaga actacgacct ggaatgcatg      180

agcatgggct gcgtgagcgg ctgcctgtgc ccacccggca tggtccggca cgagaacaga      240

tgcgtggccc tggaacggtg cccatgcttc caccagggca aagagtacgc ccctggcgag      300

acagtgaaga tcggctgcaa tacctgcgtg tgccgggacc ggaagtggaa ctgcaccgac      360

cacgtgtgcg acgccacatg cagcaccatc ggcatggccc actacctgac ctttgacggc      420

ctgaagtacc tgttccccgg cgagtgccag tacgtgctgg tgcaggacta ctgcggcagc      480

aaccccggca ccttccggat cctcgtgggc aacaagggat gcagccaccc cagcgtgaag      540

tgcaagaaac gcgtgaccat cctggtggag ggcggcgaga tcgagctgtt cgacggcgaa      600

gtgaacgtga agcggcccat gaaggacgag acacacttcg aggtggtgga gagcggccgg      660

tacatcatcc tgctgctggg caaggctctg agcgtcgtgt gggaccggca cctgagcatc      720

agcgtggtgc tgaagcagac ctaccaggaa aaagtctgcg gcctctgtgg caatttcgac      780

ggcatccaga acaacgatct gaccagcagc aacctgcagg tggaagagga ccccgtggac      840

tttggcaata gctggaaggt gtccagccag tgtgccgaca ccagaaaagt gcccctggac      900

tctagccccg ccacctgcca caacaacatc atgaagcaga caatggtgga cagctcctgc      960

cggatcctga cctccgacgt gttccaggac tgtaacaaac tggtggatcc tgagccttac     1020

ctggacgtgt gcatctacga cacctgcagc tgcgagagca tcggcgattg cgcctgcttc     1080

tgcgacacaa tcgccgccta cgcccatgtg tgcgcccagc acggcaaggt ggtcacctgg     1140

cggaccgcaa ccctgtgccc ccagagctgc gaggaacgga acctgcggga gaacggctac     1200

gagtgcgagt ggcggtacaa cagctgcgcc ccagcctgcc aggtcacctg ccagcacccc     1260

gagcctctgg cctgccccgt gcagtgcgtg gagggctgcc acgcccactg ccctccaggc     1320

aagatcctgg acgagctgct gcagacctgc gtggaccctg aggactgccc tgtgtgcgag     1380

gtggccggca ggcggttcgc ctccggcaag aaagtgaccc tgaaccctag cgaccccgag     1440

cactgccaga tctgccactg cgacgtggtc aatctgacct gcgaggcttg ccaggaacca     1500

ggcggcctcg tcgtgccccc taccgacgcc cctgtgtccc caaccaccct gtacgtggag     1560

gacatcagcg agccccccct gcacgacttc tactgctctc ggctgctgga cctggtgttc     1620

ctgctggacg gcagttctag actgagcgag gccgagttcg aggtgctgaa ggccttcgtc     1680

gtggacatga tggaacggct gcggatcagc cagaaatggg tccgggtggc cgtggtggag     1740

taccacgacg gcagccacgc ctacatcggc ctgaaggacc ggaagcggcc ctccgaactc     1800

cggcggatcg ccagccaggt caagtacgcc ggatcccagg tggccagcac cagcgaagtg     1860

ctgaagtaca ccctgttcca gatcttcagc aagatcgacc ggcccgaggc cagccggatc     1920

gcactgctgc tgatggccag ccaagaaccc cagcggatga gccggaactt cgtgagatac     1980

gtgcagggcc tgaagaaaaa gaaagtgatc gtgatccccg tgggcatcgg cccccacgcc     2040

aacctgaagc agatccggct gatcgagaag caggcacccg agaacaaggc ctttgtgctg     2100

tccagcgtgg atgagctgga acagcagcgg gacgagatcg tgtcctacct gtgcgacctg     2160

gcccctgagg cccctcctcc cacactgccc ccccacatgg ctcaggtcac cgtgggacca     2220

ggcgacaaaa ctcacacatg cccaccgtgc ccagcacctg aactcctggg gggaccgtca     2280

gtcttcctct tccccccaaa acccaaggac accctcatga tctcccggac ccctgaggtc     2340

acatgcgtgg tggtggacgt gagccacgaa gaccctgagg tcaagttcaa ctggtacgtg     2400

gacggcgtgg aggtgcataa tgccaagaca aagccgcggg aggagcagta caacagcacg     2460

taccgtgtgg tcagcgtcct caccgtcctg caccaggact ggctgaatgg caaggagtac     2520

aagtgcaagg tctccaacaa agccctccca gcccccatcg agaaaaccat ctccaaagcc     2580

aaagggcagc cccgagagcc acaggtgtac accctgcccc catcccggga tgagctgacc     2640

aagaaccagg tcagcctgac ctgcctggtc aaaggcttct atcccagcga catcgccgtg     2700

gagtgggaga gcaatgggca gccggagaac aactacaaga ccacgcctcc cgtgctggac     2760

tccgacggct ccttcttcct ctacagcaag ctcaccgtgg acaagagcag gtggcagcag     2820

gggaacgtct tctcatgctc cgtgatgcat gaggctctgc acaaccacta cacgcagaag     2880

agcctctccc tgtctccggg taaa                                            2904


<210>  28
<211>  5124
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  sequence

<400>  28
atgatccccg ccagattcgc cggcgtgctg ctggccctgg ccctgatcct gcccggcacc       60

ctgtgcgccg agggcaccag aggcagatcc agcaccgccc ggtgcagcct gttcggcagc      120

gacttcgtga acaccttcga cggcagcatg tacagcttcg ccggctactg tagctacctg      180

ctggctggcg gctgccagaa gcggagcttc agcatcatcg gcgacttcca gaacggcaag      240

cgggtgtccc tgagcgtgta cctgggcgag ttcttcgaca tccacctgtt cgtgaacggc      300

accgtgaccc agggcgatca gagggtgtcc atgccctacg ccagcaaggg cctgtacctg      360

gaaaccgagg ccggctacta caagctgtcc ggcgaggcct acggcttcgt ggcccggatc      420

gacggctccg gcaacttcca ggtgctgctg tccgaccggt acttcaacaa gacctgcggc      480

ctgtgcggca acttcaacat cttcgccgag gacgacttca tgacccagga aggcaccctg      540

accagcgacc cctacgactt cgccaacagc tgggccctga gcagcggcga gcagtggtgc      600

gagagagcca gcccccccag cagcagctgc aacatcagct ccggcgagat gcagaaaggc      660

ctgtgggagc agtgccagct gctgaagtcc acctccgtgt tcgcccggtg ccaccccctg      720

gtggaccccg agccctttgt ggccctgtgc gaaaagaccc tgtgcgagtg cgctggcggc      780

ctggaatgcg cctgccctgc cctgctggaa tacgcccgga cctgcgccca agaagggatg      840

gtcctgtacg gctggaccga ccacagcgcc tgcagccccg tctgccctgc cggcatggaa      900

taccggcagt gcgtgagccc ctgcgccaga acctgccaga gcctgcacat caacgagatg      960

tgccaggaaa gatgcgtcga cggctgctct tgtcccgagg gacagctcct ggacgagggc     1020

ctctgcgtgg agagcaccga gtgcccctgc gtgcacagcg gcaagagata cccccctggc     1080

accagcctga gccgggactg caacacctgc atttgccgga acagccagtg gatctgcagc     1140

aacgaggaat gcccaggcga gtgcctggtc accggccaga gccacttcaa gagcttcgac     1200

aacagatact tcaccttcag cggcatctgc cagtatctgc tggccagaga ctgccaggac     1260

cacagcttct ccatcgtgat cgagacagtg cagtgcgccg acgaccggga cgccgtgtgc     1320

accagatccg tgaccgtgag actgcccggc ctgcacaaca gcctggtcaa gctgaagcat     1380

ggcgctggcg tggccatgga cggccaggac atccagctgc ctctgctgaa gggcgacctg     1440

cggatccagc acaccgtgac cgccagcgtg agactgtcct acggcgagga cctgcagatg     1500

gactgggacg gcagaggccg gctgctcgtg aagctgtccc ccgtgtacgc cggcaagaca     1560

tgtggcctgt gtgggaacta caacggcaac cagggcgacg actttctgac ccccagcggc     1620

ctggccgagc ccagagtgga ggacttcggc aacgcctgga agctgcacgg cgattgccag     1680

gatctgcaga aacagcactc cgacccctgc gccctgaacc cccggatgac ccggttcagc     1740

gaagaggctt gcgccgtgct gaccagcccc accttcgagg cctgccaccg ggccgtgagc     1800

cccctgccct acctgcggaa ctgcagatac gatgtgtgta gctgctctga cggccgggag     1860

tgcctgtgtg gcgccctggc cagctatgcc gctgcctgcg ccggacgcgg tgtgagagtg     1920

gcttggcggg agcctggcag atgcgagctg aactgcccca agggccaggt gtacctgcag     1980

tgcggcaccc cctgcaacct gacctgccgg tccctgagct accccgacga agagtgcaac     2040

gaggcctgtc tcgaaggctg cttctgcccc cctggcctgt acatggacga gcggggcgac     2100

tgcgtgccca aggcccagtg cccctgttac tacgacggcg agatcttcca gcccgaggac     2160

atcttcagcg accaccacac catgtgctac tgcgaggacg gctttatgca ctgcaccatg     2220

agcggcgtgc ccggcagcct gctgccagac gccgtgctgt cctcccccct gagccaccgg     2280

tccaagcgga gcctgagctg cagacccccc atggtcaagc tcgtgtgccc agccgacaat     2340

ctgcgggccg aggggctgga atgcaccaag acctgccaga actacgacct ggaatgcatg     2400

agcatgggct gcgtgagcgg ctgcctgtgc ccacccggca tggtccggca cgagaacaga     2460

tgcgtggccc tggaacggtg cccatgcttc caccagggca aagagtacgc ccctggcgag     2520

acagtgaaga tcggctgcaa tacctgcgtg tgccgggacc ggaagtggaa ctgcaccgac     2580

cacgtgtgcg acgccacatg cagcaccatc ggcatggccc actacctgac ctttgacggc     2640

ctgaagtacc tgttccccgg cgagtgccag tacgtgctgg tgcaggacta ctgcggcagc     2700

aaccccggca ccttccggat cctcgtgggc aacaagggat gcagccaccc cagcgtgaag     2760

tgcaagaaac gcgtgaccat cctggtggag ggcggcgaga tcgagctgtt cgacggcgaa     2820

gtgaacgtga agcggcccat gaaggacgag acacacttcg aggtggtgga gagcggccgg     2880

tacatcatcc tgctgctggg caaggctctg agcgtcgtgt gggaccggca cctgagcatc     2940

agcgtggtgc tgaagcagac ctaccaggaa aaagtctgcg gcctctgtgg caatttcgac     3000

ggcatccaga acaacgatct gaccagcagc aacctgcagg tggaagagga ccccgtggac     3060

tttggcaata gctggaaggt gtccagccag tgtgccgaca ccagaaaagt gcccctggac     3120

tctagccccg ccacctgcca caacaacatc atgaagcaga caatggtgga cagctcctgc     3180

cggatcctga cctccgacgt gttccaggac tgtaacaaac tggtggatcc tgagccttac     3240

ctggacgtgt gcatctacga cacctgcagc tgcgagagca tcggcgattg cgcctgcttc     3300

tgcgacacaa tcgccgccta cgcccatgtg tgcgcccagc acggcaaggt ggtcacctgg     3360

cggaccgcaa ccctgtgccc ccagagctgc gaggaacgga acctgcggga gaacggctac     3420

gagtgcgagt ggcggtacaa cagctgcgcc ccagcctgcc aggtcacctg ccagcacccc     3480

gagcctctgg cctgccccgt gcagtgcgtg gagggctgcc acgcccactg ccctccaggc     3540

aagatcctgg acgagctgct gcagacctgc gtggaccctg aggactgccc tgtgtgcgag     3600

gtggccggca ggcggttcgc ctccggcaag aaagtgaccc tgaaccctag cgaccccgag     3660

cactgccaga tctgccactg cgacgtggtc aatctgacct gcgaggcttg ccaggaacca     3720

ggcggcctcg tcgtgccccc taccgacgcc cctgtgtccc caaccaccct gtacgtggag     3780

gacatcagcg agccccccct gcacgacttc tactgctctc ggctgctgga cctggtgttc     3840

ctgctggacg gcagttctag actgagcgag gccgagttcg aggtgctgaa ggccttcgtc     3900

gtggacatga tggaacggct gcggatcagc cagaaatggg tccgggtggc cgtggtggag     3960

taccacgacg gcagccacgc ctacatcggc ctgaaggacc ggaagcggcc ctccgaactc     4020

cggcggatcg ccagccaggt caagtacgcc ggatcccagg tggccagcac cagcgaagtg     4080

ctgaagtaca ccctgttcca gatcttcagc aagatcgacc ggcccgaggc cagccggatc     4140

gcactgctgc tgatggccag ccaagaaccc cagcggatga gccggaactt cgtgagatac     4200

gtgcagggcc tgaagaaaaa gaaagtgatc gtgatccccg tgggcatcgg cccccacgcc     4260

aacctgaagc agatccggct gatcgagaag caggcacccg agaacaaggc ctttgtgctg     4320

tccagcgtgg atgagctgga acagcagcgg gacgagatcg tgtcctacct gtgcgacctg     4380

gcccctgagg cccctcctcc cacactgccc ccccacatgg ctcaggtcac cgtgggacca     4440

ggcgacaaaa ctcacacatg cccaccgtgc ccagcacctg aactcctggg gggaccgtca     4500

gtcttcctct tccccccaaa acccaaggac accctcatga tctcccggac ccctgaggtc     4560

acatgcgtgg tggtggacgt gagccacgaa gaccctgagg tcaagttcaa ctggtacgtg     4620

gacggcgtgg aggtgcataa tgccaagaca aagccgcggg aggagcagta caacagcacg     4680

taccgtgtgg tcagcgtcct caccgtcctg caccaggact ggctgaatgg caaggagtac     4740

aagtgcaagg tctccaacaa agccctccca gcccccatcg agaaaaccat ctccaaagcc     4800

aaagggcagc cccgagagcc acaggtgtac accctgcccc catcccggga tgagctgacc     4860

aagaaccagg tcagcctgac ctgcctggtc aaaggcttct atcccagcga catcgccgtg     4920

gagtgggaga gcaatgggca gccggagaac aactacaaga ccacgcctcc cgtgctggac     4980

tccgacggct ccttcttcct ctacagcaag ctcaccgtgg acaagagcag gtggcagcag     5040

gggaacgtct tctcatgctc cgtgatgcat gaggctctgc acaaccacta cacgcagaag     5100

agcctctccc tgtctccggg taaa                                            5124


<210>  29
<211>  2813
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  sequence

<400>  29

Met Ile Pro Ala Arg Phe Ala Gly Val Leu Leu Ala Leu Ala Leu Ile 
1               5                   10                  15      


Leu Pro Gly Thr Leu Cys Ala Glu Gly Thr Arg Gly Arg Ser Ser Thr 
            20                  25                  30          


Ala Arg Cys Ser Leu Phe Gly Ser Asp Phe Val Asn Thr Phe Asp Gly 
        35                  40                  45              


Ser Met Tyr Ser Phe Ala Gly Tyr Cys Ser Tyr Leu Leu Ala Gly Gly 
    50                  55                  60                  


Cys Gln Lys Arg Ser Phe Ser Ile Ile Gly Asp Phe Gln Asn Gly Lys 
65                  70                  75                  80  


Arg Val Ser Leu Ser Val Tyr Leu Gly Glu Phe Phe Asp Ile His Leu 
                85                  90                  95      


Phe Val Asn Gly Thr Val Thr Gln Gly Asp Gln Arg Val Ser Met Pro 
            100                 105                 110         


Tyr Ala Ser Lys Gly Leu Tyr Leu Glu Thr Glu Ala Gly Tyr Tyr Lys 
        115                 120                 125             


Leu Ser Gly Glu Ala Tyr Gly Phe Val Ala Arg Ile Asp Gly Ser Gly 
    130                 135                 140                 


Asn Phe Gln Val Leu Leu Ser Asp Arg Tyr Phe Asn Lys Thr Cys Gly 
145                 150                 155                 160 


Leu Cys Gly Asn Phe Asn Ile Phe Ala Glu Asp Asp Phe Met Thr Gln 
                165                 170                 175     


Glu Gly Thr Leu Thr Ser Asp Pro Tyr Asp Phe Ala Asn Ser Trp Ala 
            180                 185                 190         


Leu Ser Ser Gly Glu Gln Trp Cys Glu Arg Ala Ser Pro Pro Ser Ser 
        195                 200                 205             


Ser Cys Asn Ile Ser Ser Gly Glu Met Gln Lys Gly Leu Trp Glu Gln 
    210                 215                 220                 


Cys Gln Leu Leu Lys Ser Thr Ser Val Phe Ala Arg Cys His Pro Leu 
225                 230                 235                 240 


Val Asp Pro Glu Pro Phe Val Ala Leu Cys Glu Lys Thr Leu Cys Glu 
                245                 250                 255     


Cys Ala Gly Gly Leu Glu Cys Ala Cys Pro Ala Leu Leu Glu Tyr Ala 
            260                 265                 270         


Arg Thr Cys Ala Gln Glu Gly Met Val Leu Tyr Gly Trp Thr Asp His 
        275                 280                 285             


Ser Ala Cys Ser Pro Val Cys Pro Ala Gly Met Glu Tyr Arg Gln Cys 
    290                 295                 300                 


Val Ser Pro Cys Ala Arg Thr Cys Gln Ser Leu His Ile Asn Glu Met 
305                 310                 315                 320 


Cys Gln Glu Arg Cys Val Asp Gly Cys Ser Cys Pro Glu Gly Gln Leu 
                325                 330                 335     


Leu Asp Glu Gly Leu Cys Val Glu Ser Thr Glu Cys Pro Cys Val His 
            340                 345                 350         


Ser Gly Lys Arg Tyr Pro Pro Gly Thr Ser Leu Ser Arg Asp Cys Asn 
        355                 360                 365             


Thr Cys Ile Cys Arg Asn Ser Gln Trp Ile Cys Ser Asn Glu Glu Cys 
    370                 375                 380                 


Pro Gly Glu Cys Leu Val Thr Gly Gln Ser His Phe Lys Ser Phe Asp 
385                 390                 395                 400 


Asn Arg Tyr Phe Thr Phe Ser Gly Ile Cys Gln Tyr Leu Leu Ala Arg 
                405                 410                 415     


Asp Cys Gln Asp His Ser Phe Ser Ile Val Ile Glu Thr Val Gln Cys 
            420                 425                 430         


Ala Asp Asp Arg Asp Ala Val Cys Thr Arg Ser Val Thr Val Arg Leu 
        435                 440                 445             


Pro Gly Leu His Asn Ser Leu Val Lys Leu Lys His Gly Ala Gly Val 
    450                 455                 460                 


Ala Met Asp Gly Gln Asp Ile Gln Leu Pro Leu Leu Lys Gly Asp Leu 
465                 470                 475                 480 


Arg Ile Gln His Thr Val Thr Ala Ser Val Arg Leu Ser Tyr Gly Glu 
                485                 490                 495     


Asp Leu Gln Met Asp Trp Asp Gly Arg Gly Arg Leu Leu Val Lys Leu 
            500                 505                 510         


Ser Pro Val Tyr Ala Gly Lys Thr Cys Gly Leu Cys Gly Asn Tyr Asn 
        515                 520                 525             


Gly Asn Gln Gly Asp Asp Phe Leu Thr Pro Ser Gly Leu Ala Glu Pro 
    530                 535                 540                 


Arg Val Glu Asp Phe Gly Asn Ala Trp Lys Leu His Gly Asp Cys Gln 
545                 550                 555                 560 


Asp Leu Gln Lys Gln His Ser Asp Pro Cys Ala Leu Asn Pro Arg Met 
                565                 570                 575     


Thr Arg Phe Ser Glu Glu Ala Cys Ala Val Leu Thr Ser Pro Thr Phe 
            580                 585                 590         


Glu Ala Cys His Arg Ala Val Ser Pro Leu Pro Tyr Leu Arg Asn Cys 
        595                 600                 605             


Arg Tyr Asp Val Cys Ser Cys Ser Asp Gly Arg Glu Cys Leu Cys Gly 
    610                 615                 620                 


Ala Leu Ala Ser Tyr Ala Ala Ala Cys Ala Gly Arg Gly Val Arg Val 
625                 630                 635                 640 


Ala Trp Arg Glu Pro Gly Arg Cys Glu Leu Asn Cys Pro Lys Gly Gln 
                645                 650                 655     


Val Tyr Leu Gln Cys Gly Thr Pro Cys Asn Leu Thr Cys Arg Ser Leu 
            660                 665                 670         


Ser Tyr Pro Asp Glu Glu Cys Asn Glu Ala Cys Leu Glu Gly Cys Phe 
        675                 680                 685             


Cys Pro Pro Gly Leu Tyr Met Asp Glu Arg Gly Asp Cys Val Pro Lys 
    690                 695                 700                 


Ala Gln Cys Pro Cys Tyr Tyr Asp Gly Glu Ile Phe Gln Pro Glu Asp 
705                 710                 715                 720 


Ile Phe Ser Asp His His Thr Met Cys Tyr Cys Glu Asp Gly Phe Met 
                725                 730                 735     


His Cys Thr Met Ser Gly Val Pro Gly Ser Leu Leu Pro Asp Ala Val 
            740                 745                 750         


Leu Ser Ser Pro Leu Ser His Arg Ser Lys Arg Ser Leu Ser Cys Arg 
        755                 760                 765             


Pro Pro Met Val Lys Leu Val Cys Pro Ala Asp Asn Leu Arg Ala Glu 
    770                 775                 780                 


Gly Leu Glu Cys Thr Lys Thr Cys Gln Asn Tyr Asp Leu Glu Cys Met 
785                 790                 795                 800 


Ser Met Gly Cys Val Ser Gly Cys Leu Cys Pro Pro Gly Met Val Arg 
                805                 810                 815     


His Glu Asn Arg Cys Val Ala Leu Glu Arg Cys Pro Cys Phe His Gln 
            820                 825                 830         


Gly Lys Glu Tyr Ala Pro Gly Glu Thr Val Lys Ile Gly Cys Asn Thr 
        835                 840                 845             


Cys Val Cys Arg Asp Arg Lys Trp Asn Cys Thr Asp His Val Cys Asp 
    850                 855                 860                 


Ala Thr Cys Ser Thr Ile Gly Met Ala His Tyr Leu Thr Phe Asp Gly 
865                 870                 875                 880 


Leu Lys Tyr Leu Phe Pro Gly Glu Cys Gln Tyr Val Leu Val Gln Asp 
                885                 890                 895     


Tyr Cys Gly Ser Asn Pro Gly Thr Phe Arg Ile Leu Val Gly Asn Lys 
            900                 905                 910         


Gly Cys Ser His Pro Ser Val Lys Cys Lys Lys Arg Val Thr Ile Leu 
        915                 920                 925             


Val Glu Gly Gly Glu Ile Glu Leu Phe Asp Gly Glu Val Asn Val Lys 
    930                 935                 940                 


Arg Pro Met Lys Asp Glu Thr His Phe Glu Val Val Glu Ser Gly Arg 
945                 950                 955                 960 


Tyr Ile Ile Leu Leu Leu Gly Lys Ala Leu Ser Val Val Trp Asp Arg 
                965                 970                 975     


His Leu Ser Ile Ser Val Val Leu Lys Gln Thr Tyr Gln Glu Lys Val 
            980                 985                 990         


Cys Gly Leu Cys Gly Asn Phe Asp  Gly Ile Gln Asn Asn  Asp Leu Thr 
        995                 1000                 1005             


Ser Ser  Asn Leu Gln Val Glu  Glu Asp Pro Val Asp  Phe Gly Asn 
    1010                 1015                 1020             


Ser Trp  Lys Val Ser Ser Gln  Cys Ala Asp Thr Arg  Lys Val Pro 
    1025                 1030                 1035             


Leu Asp  Ser Ser Pro Ala Thr  Cys His Asn Asn Ile  Met Lys Gln 
    1040                 1045                 1050             


Thr Met  Val Asp Ser Ser Cys  Arg Ile Leu Thr Ser  Asp Val Phe 
    1055                 1060                 1065             


Gln Asp  Cys Asn Lys Leu Val  Asp Pro Glu Pro Tyr  Leu Asp Val 
    1070                 1075                 1080             


Cys Ile  Tyr Asp Thr Cys Ser  Cys Glu Ser Ile Gly  Asp Cys Ala 
    1085                 1090                 1095             


Cys Phe  Cys Asp Thr Ile Ala  Ala Tyr Ala His Val  Cys Ala Gln 
    1100                 1105                 1110             


His Gly  Lys Val Val Thr Trp  Arg Thr Ala Thr Leu  Cys Pro Gln 
    1115                 1120                 1125             


Ser Cys  Glu Glu Arg Asn Leu  Arg Glu Asn Gly Tyr  Glu Cys Glu 
    1130                 1135                 1140             


Trp Arg  Tyr Asn Ser Cys Ala  Pro Ala Cys Gln Val  Thr Cys Gln 
    1145                 1150                 1155             


His Pro  Glu Pro Leu Ala Cys  Pro Val Gln Cys Val  Glu Gly Cys 
    1160                 1165                 1170             


His Ala  His Cys Pro Pro Gly  Lys Ile Leu Asp Glu  Leu Leu Gln 
    1175                 1180                 1185             


Thr Cys  Val Asp Pro Glu Asp  Cys Pro Val Cys Glu  Val Ala Gly 
    1190                 1195                 1200             


Arg Arg  Phe Ala Ser Gly Lys  Lys Val Thr Leu Asn  Pro Ser Asp 
    1205                 1210                 1215             


Pro Glu  His Cys Gln Ile Cys  His Cys Asp Val Val  Asn Leu Thr 
    1220                 1225                 1230             


Cys Glu  Ala Cys Gln Glu Pro  Gly Gly Leu Val Val  Pro Pro Thr 
    1235                 1240                 1245             


Asp Ala  Pro Val Ser Pro Thr  Thr Leu Tyr Val Glu  Asp Ile Ser 
    1250                 1255                 1260             


Glu Pro  Pro Leu His Asp Phe  Tyr Cys Ser Arg Leu  Leu Asp Leu 
    1265                 1270                 1275             


Val Phe  Leu Leu Asp Gly Ser  Ser Arg Leu Ser Glu  Ala Glu Phe 
    1280                 1285                 1290             


Glu Val  Leu Lys Ala Phe Val  Val Asp Met Met Glu  Arg Leu Arg 
    1295                 1300                 1305             


Ile Ser  Gln Lys Trp Val Arg  Val Ala Val Val Glu  Tyr His Asp 
    1310                 1315                 1320             


Gly Ser  His Ala Tyr Ile Gly  Leu Lys Asp Arg Lys  Arg Pro Ser 
    1325                 1330                 1335             


Glu Leu  Arg Arg Ile Ala Ser  Gln Val Lys Tyr Ala  Gly Ser Gln 
    1340                 1345                 1350             


Val Ala  Ser Thr Ser Glu Val  Leu Lys Tyr Thr Leu  Phe Gln Ile 
    1355                 1360                 1365             


Phe Ser  Lys Ile Asp Arg Pro  Glu Ala Ser Arg Ile  Ala Leu Leu 
    1370                 1375                 1380             


Leu Met  Ala Ser Gln Glu Pro  Gln Arg Met Ser Arg  Asn Phe Val 
    1385                 1390                 1395             


Arg Tyr  Val Gln Gly Leu Lys  Lys Lys Lys Val Ile  Val Ile Pro 
    1400                 1405                 1410             


Val Gly  Ile Gly Pro His Ala  Asn Leu Lys Gln Ile  Arg Leu Ile 
    1415                 1420                 1425             


Glu Lys  Gln Ala Pro Glu Asn  Lys Ala Phe Val Leu  Ser Ser Val 
    1430                 1435                 1440             


Asp Glu  Leu Glu Gln Gln Arg  Asp Glu Ile Val Ser  Tyr Leu Cys 
    1445                 1450                 1455             


Asp Leu  Ala Pro Glu Ala Pro  Pro Pro Thr Leu Pro  Pro His Met 
    1460                 1465                 1470             


Ala Gln  Val Thr Val Gly Pro  Gly Leu Leu Gly Val  Ser Thr Leu 
    1475                 1480                 1485             


Gly Pro  Lys Arg Asn Ser Met  Val Leu Asp Val Ala  Phe Val Leu 
    1490                 1495                 1500             


Glu Gly  Ser Asp Lys Ile Gly  Glu Ala Asp Phe Asn  Arg Ser Lys 
    1505                 1510                 1515             


Glu Phe  Met Glu Glu Val Ile  Gln Arg Met Asp Val  Gly Gln Asp 
    1520                 1525                 1530             


Ser Ile  His Val Thr Val Leu  Gln Tyr Ser Tyr Met  Val Thr Val 
    1535                 1540                 1545             


Glu Tyr  Pro Phe Ser Glu Ala  Gln Ser Lys Gly Asp  Ile Leu Gln 
    1550                 1555                 1560             


Arg Val  Arg Glu Ile Arg Tyr  Gln Gly Gly Asn Arg  Thr Asn Thr 
    1565                 1570                 1575             


Gly Leu  Ala Leu Arg Tyr Leu  Ser Asp His Ser Phe  Leu Val Ser 
    1580                 1585                 1590             


Gln Gly  Asp Arg Glu Gln Ala  Pro Asn Leu Val Tyr  Met Val Thr 
    1595                 1600                 1605             


Gly Asn  Pro Ala Ser Asp Glu  Ile Lys Arg Leu Pro  Gly Asp Ile 
    1610                 1615                 1620             


Gln Val  Val Pro Ile Gly Val  Gly Pro Asn Ala Asn  Val Gln Glu 
    1625                 1630                 1635             


Leu Glu  Arg Ile Gly Trp Pro  Asn Ala Pro Ile Leu  Ile Gln Asp 
    1640                 1645                 1650             


Phe Glu  Thr Leu Pro Arg Glu  Ala Pro Asp Leu Val  Leu Gln Arg 
    1655                 1660                 1665             


Cys Cys  Ser Gly Glu Gly Leu  Gln Ile Pro Thr Leu  Ser Pro Ala 
    1670                 1675                 1680             


Pro Asp  Cys Ser Gln Pro Leu  Asp Val Ile Leu Leu  Leu Asp Gly 
    1685                 1690                 1695             


Ser Ser  Ser Phe Pro Ala Ser  Tyr Phe Asp Glu Met  Lys Ser Phe 
    1700                 1705                 1710             


Ala Lys  Ala Phe Ile Ser Lys  Ala Asn Ile Gly Pro  Arg Leu Thr 
    1715                 1720                 1725             


Gln Val  Ser Val Leu Gln Tyr  Gly Ser Ile Thr Thr  Ile Asp Val 
    1730                 1735                 1740             


Pro Trp  Asn Val Val Pro Glu  Lys Ala His Leu Leu  Ser Leu Val 
    1745                 1750                 1755             


Asp Val  Met Gln Arg Glu Gly  Gly Pro Ser Gln Ile  Gly Asp Ala 
    1760                 1765                 1770             


Leu Gly  Phe Ala Val Arg Tyr  Leu Thr Ser Glu Met  His Gly Ala 
    1775                 1780                 1785             


Arg Pro  Gly Ala Ser Lys Ala  Val Val Ile Leu Val  Thr Asp Val 
    1790                 1795                 1800             


Ser Val  Asp Ser Val Asp Ala  Ala Ala Asp Ala Ala  Arg Ser Asn 
    1805                 1810                 1815             


Arg Val  Thr Val Phe Pro Ile  Gly Ile Gly Asp Arg  Tyr Asp Ala 
    1820                 1825                 1830             


Ala Gln  Leu Arg Ile Leu Ala  Gly Pro Ala Gly Asp  Ser Asn Val 
    1835                 1840                 1845             


Val Lys  Leu Gln Arg Ile Glu  Asp Leu Pro Thr Met  Val Thr Leu 
    1850                 1855                 1860             


Gly Asn  Ser Phe Leu His Lys  Leu Cys Ser Gly Phe  Val Arg Ile 
    1865                 1870                 1875             


Cys Met  Asp Glu Asp Gly Asn  Glu Lys Arg Pro Gly  Asp Val Trp 
    1880                 1885                 1890             


Thr Leu  Pro Asp Gln Cys His  Thr Val Thr Cys Gln  Pro Asp Gly 
    1895                 1900                 1905             


Gln Thr  Leu Leu Lys Ser His  Arg Val Asn Cys Asp  Arg Gly Leu 
    1910                 1915                 1920             


Arg Pro  Ser Cys Pro Asn Ser  Gln Ser Pro Val Lys  Val Glu Glu 
    1925                 1930                 1935             


Thr Cys  Gly Cys Arg Trp Thr  Cys Pro Cys Val Cys  Thr Gly Ser 
    1940                 1945                 1950             


Ser Thr  Arg His Ile Val Thr  Phe Asp Gly Gln Asn  Phe Lys Leu 
    1955                 1960                 1965             


Thr Gly  Ser Cys Ser Tyr Val  Leu Phe Gln Asn Lys  Glu Gln Asp 
    1970                 1975                 1980             


Leu Glu  Val Ile Leu His Asn  Gly Ala Cys Ser Pro  Gly Ala Arg 
    1985                 1990                 1995             


Gln Gly  Cys Met Lys Ser Ile  Glu Val Lys His Ser  Ala Leu Ser 
    2000                 2005                 2010             


Val Glu  Leu His Ser Asp Met  Glu Val Thr Val Asn  Gly Arg Leu 
    2015                 2020                 2025             


Val Ser  Val Pro Tyr Val Gly  Gly Asn Met Glu Val  Asn Val Tyr 
    2030                 2035                 2040             


Gly Ala  Ile Met His Glu Val  Arg Phe Asn His Leu  Gly His Ile 
    2045                 2050                 2055             


Phe Thr  Phe Thr Pro Gln Asn  Asn Glu Phe Gln Leu  Gln Leu Ser 
    2060                 2065                 2070             


Pro Lys  Thr Phe Ala Ser Lys  Thr Tyr Gly Leu Cys  Gly Ile Cys 
    2075                 2080                 2085             


Asp Glu  Asn Gly Ala Asn Asp  Phe Met Leu Arg Asp  Gly Thr Val 
    2090                 2095                 2100             


Thr Thr  Asp Trp Lys Thr Leu  Val Gln Glu Trp Thr  Val Gln Arg 
    2105                 2110                 2115             


Pro Gly  Gln Thr Cys Gln Pro  Ile Leu Glu Glu Gln  Cys Leu Val 
    2120                 2125                 2130             


Pro Asp  Ser Ser His Cys Gln  Val Leu Leu Leu Pro  Leu Phe Ala 
    2135                 2140                 2145             


Glu Cys  His Lys Val Leu Ala  Pro Ala Thr Phe Tyr  Ala Ile Cys 
    2150                 2155                 2160             


Gln Gln  Asp Ser Cys His Gln  Glu Gln Val Cys Glu  Val Ile Ala 
    2165                 2170                 2175             


Ser Tyr  Ala His Leu Cys Arg  Thr Asn Gly Val Cys  Val Asp Trp 
    2180                 2185                 2190             


Arg Thr  Pro Asp Phe Cys Ala  Met Ser Cys Pro Pro  Ser Leu Val 
    2195                 2200                 2205             


Tyr Asn  His Cys Glu His Gly  Cys Pro Arg His Cys  Asp Gly Asn 
    2210                 2215                 2220             


Val Ser  Ser Cys Gly Asp His  Pro Ser Glu Gly Cys  Phe Cys Pro 
    2225                 2230                 2235             


Pro Asp  Lys Val Met Leu Glu  Gly Ser Cys Val Pro  Glu Glu Ala 
    2240                 2245                 2250             


Cys Thr  Gln Cys Ile Gly Glu  Asp Gly Val Gln His  Gln Phe Leu 
    2255                 2260                 2265             


Glu Ala  Trp Val Pro Asp His  Gln Pro Cys Gln Ile  Cys Thr Cys 
    2270                 2275                 2280             


Leu Ser  Gly Arg Lys Val Asn  Cys Thr Thr Gln Pro  Cys Pro Thr 
    2285                 2290                 2295             


Ala Lys  Ala Pro Thr Cys Gly  Leu Cys Glu Val Ala  Arg Leu Arg 
    2300                 2305                 2310             


Gln Asn  Ala Asp Gln Cys Cys  Pro Glu Tyr Glu Cys  Val Cys Asp 
    2315                 2320                 2325             


Pro Val  Ser Cys Asp Leu Pro  Pro Val Pro His Cys  Glu Arg Gly 
    2330                 2335                 2340             


Leu Gln  Pro Thr Leu Thr Asn  Pro Gly Glu Cys Arg  Pro Asn Phe 
    2345                 2350                 2355             


Thr Cys  Ala Cys Arg Lys Glu  Glu Cys Lys Arg Val  Ser Pro Pro 
    2360                 2365                 2370             


Ser Cys  Pro Pro His Arg Leu  Pro Thr Leu Arg Lys  Thr Gln Cys 
    2375                 2380                 2385             


Cys Asp  Glu Tyr Glu Cys Ala  Cys Asn Cys Val Asn  Ser Thr Val 
    2390                 2395                 2400             


Ser Cys  Pro Leu Gly Tyr Leu  Ala Ser Thr Ala Thr  Asn Asp Cys 
    2405                 2410                 2415             


Gly Cys  Thr Thr Thr Thr Cys  Leu Pro Asp Lys Val  Cys Val His 
    2420                 2425                 2430             


Arg Ser  Thr Ile Tyr Pro Val  Gly Gln Phe Trp Glu  Glu Gly Cys 
    2435                 2440                 2445             


Asp Val  Cys Thr Cys Thr Asp  Met Glu Asp Ala Val  Met Gly Leu 
    2450                 2455                 2460             


Arg Val  Ala Gln Cys Ser Gln  Lys Pro Cys Glu Asp  Ser Cys Arg 
    2465                 2470                 2475             


Ser Gly  Phe Thr Tyr Val Leu  His Glu Gly Glu Cys  Cys Gly Arg 
    2480                 2485                 2490             


Cys Leu  Pro Ser Ala Cys Glu  Val Val Thr Gly Ser  Pro Arg Gly 
    2495                 2500                 2505             


Asp Ser  Gln Ser Ser Trp Lys  Ser Val Gly Ser Gln  Trp Ala Ser 
    2510                 2515                 2520             


Pro Glu  Asn Pro Cys Leu Ile  Asn Glu Cys Val Arg  Val Lys Glu 
    2525                 2530                 2535             


Glu Val  Phe Ile Gln Gln Arg  Asn Val Ser Cys Pro  Gln Leu Glu 
    2540                 2545                 2550             


Val Pro  Val Cys Pro Ser Gly  Phe Gln Leu Ser Cys  Lys Thr Ser 
    2555                 2560                 2565             


Ala Cys  Cys Pro Ser Cys Arg  Cys Glu Arg Met Glu  Ala Cys Met 
    2570                 2575                 2580             


Leu Asn  Gly Thr Val Ile Gly  Pro Gly Lys Thr Val  Met Ile Asp 
    2585                 2590                 2595             


Val Cys  Thr Thr Cys Arg Cys  Met Val Gln Val Gly  Val Ile Ser 
    2600                 2605                 2610             


Gly Phe  Lys Leu Glu Cys Arg  Lys Thr Thr Cys Asn  Pro Cys Pro 
    2615                 2620                 2625             


Leu Gly  Tyr Lys Glu Glu Asn  Asn Thr Gly Glu Cys  Cys Gly Arg 
    2630                 2635                 2640             


Cys Leu  Pro Thr Ala Cys Thr  Ile Gln Leu Arg Gly  Gly Gln Ile 
    2645                 2650                 2655             


Met Thr  Leu Lys Arg Asp Glu  Thr Leu Gln Asp Gly  Cys Asp Thr 
    2660                 2665                 2670             


His Phe  Cys Lys Val Asn Glu  Arg Gly Glu Tyr Phe  Trp Glu Lys 
    2675                 2680                 2685             


Arg Val  Thr Gly Cys Pro Pro  Phe Asp Glu His Lys  Cys Leu Ala 
    2690                 2695                 2700             


Glu Gly  Gly Lys Ile Met Lys  Ile Pro Gly Thr Cys  Cys Asp Thr 
    2705                 2710                 2715             


Cys Glu  Glu Pro Glu Cys Asn  Asp Ile Thr Ala Arg  Leu Gln Tyr 
    2720                 2725                 2730             


Val Lys  Val Gly Ser Cys Lys  Ser Glu Val Glu Val  Asp Ile His 
    2735                 2740                 2745             


Tyr Cys  Gln Gly Lys Cys Ala  Ser Lys Ala Met Tyr  Ser Ile Asp 
    2750                 2755                 2760             


Ile Asn  Asp Val Gln Asp Gln  Cys Ser Cys Cys Ser  Pro Thr Arg 
    2765                 2770                 2775             


Thr Glu  Pro Met Gln Val Ala  Leu His Cys Thr Asn  Gly Ser Val 
    2780                 2785                 2790             


Val Tyr  His Glu Val Leu Asn  Ala Met Glu Cys Lys  Cys Ser Pro 
    2795                 2800                 2805             


Arg Lys  Cys Ser Lys 
    2810             


<210>  30
<211>  8833
<212>  DNA
<213>  Homo sapiens

<400>  30
agctcacagc tattgtggtg ggaaagggag ggtggttggt ggatgtcaca gcttgggctt       60

tatctccccc agcagtgggg actccacagc ccctgggcta cataacagca agacagtccg      120

gagctgtagc agacctgatt gagcctttgc agcagctgag agcatggcct agggtgggcg      180

gcaccattgt ccagcagctg agtttcccag ggaccttgga gatagccgca gccctcattt      240

gcaggggaag atgattcctg ccagatttgc cggggtgctg cttgctctgg ccctcatttt      300

gccagggacc ctttgtgcag aaggaactcg cggcaggtca tccacggccc gatgcagcct      360

tttcggaagt gacttcgtca acacctttga tgggagcatg tacagctttg cgggatactg      420

cagttacctc ctggcagggg gctgccagaa acgctccttc tcgattattg gggacttcca      480

gaatggcaag agagtgagcc tctccgtgta tcttggggaa ttttttgaca tccatttgtt      540

tgtcaatggt accgtgacac agggggacca aagagtctcc atgccctatg cctccaaagg      600

gctgtatcta gaaactgagg ctgggtacta caagctgtcc ggtgaggcct atggctttgt      660

ggccaggatc gatggcagcg gcaactttca agtcctgctg tcagacagat acttcaacaa      720

gacctgcggg ctgtgtggca actttaacat ctttgctgaa gatgacttta tgacccaaga      780

agggaccttg acctcggacc cttatgactt tgccaactca tgggctctga gcagtggaga      840

acagtggtgt gaacgggcat ctcctcccag cagctcatgc aacatctcct ctggggaaat      900

gcagaagggc ctgtgggagc agtgccagct tctgaagagc acctcggtgt ttgcccgctg      960

ccaccctctg gtggaccccg agccttttgt ggccctgtgt gagaagactt tgtgtgagtg     1020

tgctgggggg ctggagtgcg cctgccctgc cctcctggag tacgcccgga cctgtgccca     1080

ggagggaatg gtgctgtacg gctggaccga ccacagcgcg tgcagcccag tgtgccctgc     1140

tggtatggag tataggcagt gtgtgtcccc ttgcgccagg acctgccaga gcctgcacat     1200

caatgaaatg tgtcaggagc gatgcgtgga tggctgcagc tgccctgagg gacagctcct     1260

ggatgaaggc ctctgcgtgg agagcaccga gtgtccctgc gtgcattccg gaaagcgcta     1320

ccctcccggc acctccctct ctcgagactg caacacctgc atttgccgaa acagccagtg     1380

gatctgcagc aatgaagaat gtccagggga gtgccttgtc acaggtcaat cacacttcaa     1440

gagctttgac aacagatact tcaccttcag tgggatctgc cagtacctgc tggcccggga     1500

ttgccaggac cactccttct ccattgtcat tgagactgtc cagtgtgctg atgaccgcga     1560

cgctgtgtgc acccgctccg tcaccgtccg gctgcctggc ctgcacaaca gccttgtgaa     1620

actgaagcat ggggcaggag ttgccatgga tggccaggac gtccagctcc ccctcctgaa     1680

aggtgacctc cgcatccagc atacagtgac ggcctccgtg cgcctcagct acggggagga     1740

cctgcagatg gactgggatg gccgcgggag gctgctggtg aagctgtccc ccgtctatgc     1800

cgggaagacc tgcggcctgt gtgggaatta caatggcaac cagggcgacg acttccttac     1860

cccctctggg ctggcggagc cccgggtgga ggacttcggg aacgcctgga agctgcacgg     1920

ggactgccag gacctgcaga agcagcacag cgatccctgc gccctcaacc cgcgcatgac     1980

caggttctcc gaggaggcgt gcgcggtcct gacgtccccc acattcgagg cctgccatcg     2040

tgccgtcagc ccgctgccct acctgcggaa ctgccgctac gacgtgtgct cctgctcgga     2100

cggccgcgag tgcctgtgcg gcgccctggc cagctatgcc gcggcctgcg cggggagagg     2160

cgtgcgcgtc gcgtggcgcg agccaggccg ctgtgagctg aactgcccga aaggccaggt     2220

gtacctgcag tgcgggaccc cctgcaacct gacctgccgc tctctctctt acccggatga     2280

ggaatgcaat gaggcctgcc tggagggctg cttctgcccc ccagggctct acatggatga     2340

gaggggggac tgcgtgccca aggcccagtg cccctgttac tatgacggtg agatcttcca     2400

gccagaagac atcttctcag accatcacac catgtgctac tgtgaggatg gcttcatgca     2460

ctgtaccatg agtggagtcc ccggaagctt gctgcctgac gctgtcctca gcagtcccct     2520

gtctcatcgc agcaaaagga gcctatcctg tcggcccccc atggtcaagc tggtgtgtcc     2580

cgctgacaac ctgcgggctg aagggctcga gtgtaccaaa acgtgccaga actatgacct     2640

ggagtgcatg agcatgggct gtgtctctgg ctgcctctgc cccccgggca tggtccggca     2700

tgagaacaga tgtgtggccc tggaaaggtg tccctgcttc catcagggca aggagtatgc     2760

ccctggagaa acagtgaaga ttggctgcaa cacttgtgtc tgtcgggacc ggaagtggaa     2820

ctgcacagac catgtgtgtg atgccacgtg ctccacgatc ggcatggccc actacctcac     2880

cttcgacggg ctcaaatacc tgttccccgg ggagtgccag tacgttctgg tgcaggatta     2940

ctgcggcagt aaccctggga cctttcggat cctagtgggg aataagggat gcagccaccc     3000

ctcagtgaaa tgcaagaaac gggtcaccat cctggtggag ggaggagaga ttgagctgtt     3060

tgacggggag gtgaatgtga agaggcccat gaaggatgag actcactttg aggtggtgga     3120

gtctggccgg tacatcattc tgctgctggg caaagccctc tccgtggtct gggaccgcca     3180

cctgagcatc tccgtggtcc tgaagcagac ataccaggag aaagtgtgtg gcctgtgtgg     3240

gaattttgat ggcatccaga acaatgacct caccagcagc aacctccaag tggaggaaga     3300

ccctgtggac tttgggaact cctggaaagt gagctcgcag tgtgctgaca ccagaaaagt     3360

gcctctggac tcatcccctg ccacctgcca taacaacatc atgaagcaga cgatggtgga     3420

ttcctcctgt agaatcctta ccagtgacgt cttccaggac tgcaacaagc tggtggaccc     3480

cgagccatat ctggatgtct gcatttacga cacctgctcc tgtgagtcca ttggggactg     3540

cgcctgcttc tgcgacacca ttgctgccta tgcccacgtg tgtgcccagc atggcaaggt     3600

ggtgacctgg aggacggcca cattgtgccc ccagagctgc gaggagagga atctccggga     3660

gaacgggtat gagtgtgagt ggcgctataa cagctgtgca cctgcctgtc aagtcacgtg     3720

tcagcaccct gagccactgg cctgccctgt gcagtgtgtg gagggctgcc atgcccactg     3780

ccctccaggg aaaatcctgg atgagctttt gcagacctgc gttgaccctg aagactgtcc     3840

agtgtgtgag gtggctggcc ggcgttttgc ctcaggaaag aaagtcacct tgaatcccag     3900

tgaccctgag cactgccaga tttgccactg tgatgttgtc aacctcacct gtgaagcctg     3960

ccaggagccg ggaggcctgg tggtgcctcc cacagatgcc ccggtgagcc ccaccactct     4020

gtatgtggag gacatctcgg aaccgccgtt gcacgatttc tactgcagca ggctactgga     4080

cctggtcttc ctgctggatg gctcctccag gctgtccgag gctgagtttg aagtgctgaa     4140

ggcctttgtg gtggacatga tggagcggct gcgcatctcc cagaagtggg tccgcgtggc     4200

cgtggtggag taccacgacg gctcccacgc ctacatcggg ctcaaggacc ggaagcgacc     4260

gtcagagctg cggcgcattg ccagccaggt gaagtatgcg ggcagccagg tggcctccac     4320

cagcgaggtc ttgaaataca cactgttcca aatcttcagc aagatcgacc gccctgaagc     4380

ctcccgcatc accctgctcc tgatggccag ccaggagccc caacggatgt cccggaactt     4440

tgtccgctac gtccagggcc tgaagaagaa gaaggtcatt gtgatcccgg tgggcattgg     4500

gccccatgcc aacctcaagc agatccgcct catcgagaag caggcccctg agaacaaggc     4560

cttcgtgctg agcagtgtgg atgagctgga gcagcaaagg gacgagatcg ttagctacct     4620

ctgtgacctt gcccctgaag cccctcctcc tactctgccc cccgacatgg cacaagtcac     4680

tgtgggcccg gggctcttgg gggtttcgac cctggggccc aagaggaact ccatggttct     4740

ggatgtggcg ttcgtcctgg aaggatcgga caaaattggt gaagccgact tcaacaggag     4800

caaggagttc atggaggagg tgattcagcg gatggatgtg ggccaggaca gcatccacgt     4860

cacggtgctg cagtactcct acatggtgac tgtggagtac cccttcagcg aggcacagtc     4920

caaaggggac atcctgcagc gggtgcgaga gatccgctac cagggcggca acaggaccaa     4980

cactgggctg gccctgcggt acctctctga ccacagcttc ttggtcagcc agggtgaccg     5040

ggagcaggcg cccaacctgg tctacatggt caccggaaat cctgcctctg atgagatcaa     5100

gaggctgcct ggagacatcc aggtggtgcc cattggagtg ggccctaatg ccaacgtgca     5160

ggagctggag aggattggct ggcccaatgc ccctatcctc atccaggact ttgagacgct     5220

cccccgagag gctcctgacc tggtgctgca gaggtgctgc tccggagagg ggctgcagat     5280

ccccaccctc tcccctgcac ctgactgcag ccagcccctg gacgtgatcc ttctcctgga     5340

tggctcctcc agtttcccag cttcttattt tgatgaaatg aagagtttcg ccaaggcttt     5400

catttcaaaa gccaatatag ggcctcgtct cactcaggtg tcagtgctgc agtatggaag     5460

catcaccacc attgacgtgc catggaacgt ggtcccggag aaagcccatt tgctgagcct     5520

tgtggacgtc atgcagcggg agggaggccc cagccaaatc ggggatgcct tgggctttgc     5580

tgtgcgatac ttgacttcag aaatgcatgg tgccaggccg ggagcctcaa aggcggtggt     5640

catcctggtc acggacgtct ctgtggattc agtggatgca gcagctgatg ccgccaggtc     5700

caacagagtg acagtgttcc ctattggaat tggagatcgc tacgatgcag cccagctacg     5760

gatcttggca ggcccagcag gcgactccaa cgtggtgaag ctccagcgaa tcgaagacct     5820

ccctaccatg gtcaccttgg gcaattcctt cctccacaaa ctgtgctctg gatttgttag     5880

gatttgcatg gatgaggatg ggaatgagaa gaggcccggg gacgtctgga ccttgccaga     5940

ccagtgccac accgtgactt gccagccaga tggccagacc ttgctgaaga gtcatcgggt     6000

caactgtgac cgggggctga ggccttcgtg ccctaacagc cagtcccctg ttaaagtgga     6060

agagacctgt ggctgccgct ggacctgccc ctgcgtgtgc acaggcagct ccactcggca     6120

catcgtgacc tttgatgggc agaatttcaa gctgactggc agctgttctt atgtcctatt     6180

tcaaaacaag gagcaggacc tggaggtgat tctccataat ggtgcctgca gccctggagc     6240

aaggcagggc tgcatgaaat ccatcgaggt gaagcacagt gccctctccg tcgagctgca     6300

cagtgacatg gaggtgacgg tgaatgggag actggtctct gttccttacg tgggtgggaa     6360

catggaagtc aacgtttatg gtgccatcat gcatgaggtc agattcaatc accttggtca     6420

catcttcaca ttcactccac aaaacaatga gttccaactg cagctcagcc ccaagacttt     6480

tgcttcaaag acgtatggtc tgtgtgggat ctgtgatgag aacggagcca atgacttcat     6540

gctgagggat ggcacagtca ccacagactg gaaaacactt gttcaggaat ggactgtgca     6600

gcggccaggg cagacgtgcc agcccatcct ggaggagcag tgtcttgtcc ccgacagctc     6660

ccactgccag gtcctcctct taccactgtt tgctgaatgc cacaaggtcc tggctccagc     6720

cacattctat gccatctgcc agcaggacag ttgccaccag gagcaagtgt gtgaggtgat     6780

cgcctcttat gcccacctct gtcggaccaa cggggtctgc gttgactgga ggacacctga     6840

tttctgtgct atgtcatgcc caccatctct ggtctacaac cactgtgagc atggctgtcc     6900

ccggcactgt gatggcaacg tgagctcctg tggggaccat ccctccgaag gctgtttctg     6960

ccctccagat aaagtcatgt tggaaggcag ctgtgtccct gaagaggcct gcactcagtg     7020

cattggtgag gatggagtcc agcaccagtt cctggaagcc tgggtcccgg accaccagcc     7080

ctgtcagatc tgcacatgcc tcagcgggcg gaaggtcaac tgcacaacgc agccctgccc     7140

cacggccaaa gctcccacgt gtggcctgtg tgaagtagcc cgcctccgcc agaatgcaga     7200

ccagtgctgc cccgagtatg agtgtgtgtg tgacccagtg agctgtgacc tgcccccagt     7260

gcctcactgt gaacgtggcc tccagcccac actgaccaac cctggcgagt gcagacccaa     7320

cttcacctgc gcctgcagga aggaggagtg caaaagagtg tccccaccct cctgcccccc     7380

gcaccgtttg cccacccttc ggaagaccca gtgctgtgat gagtatgagt gtgcctgcaa     7440

ctgtgtcaac tccacagtga gctgtcccct tgggtacttg gcctcaactg ccaccaatga     7500

ctgtggctgt accacaacca cctgccttcc cgacaaggtg tgtgtccacc gaagcaccat     7560

ctaccctgtg ggccagttct gggaggaggg ctgcgatgtg tgcacctgca ccgacatgga     7620

ggatgccgtg atgggcctcc gcgtggccca gtgctcccag aagccctgtg aggacagctg     7680

tcggtcgggc ttcacttacg ttctgcatga aggcgagtgc tgtggaaggt gcctgccatc     7740

tgcctgtgag gtggtgactg gctcaccgcg gggggactcc cagtcttcct ggaagagtgt     7800

cggctcccag tgggcctccc cggagaaccc ctgcctcatc aatgagtgtg tccgagtgaa     7860

ggaggaggtc tttatacaac aaaggaacgt ctcctgcccc cagctggagg tccctgtctg     7920

cccctcgggc tttcagctga gctgtaagac ctcagcgtgc tgcccaagct gtcgctgtga     7980

gcgcatggag gcctgcatgc tcaatggcac tgtcattggg cccgggaaga ctgtgatgat     8040

cgatgtgtgc acgacctgcc gctgcatggt gcaggtgggg gtcatctctg gattcaagct     8100

ggagtgcagg aagaccacct gcaacccctg ccccctgggt tacaaggaag aaaataacac     8160

aggtgaatgt tgtgggagat gtttgcctac ggcttgcacc attcagctaa gaggaggaca     8220

gatcatgaca ctgaagcgtg atgagacgct ccaggatggc tgtgatactc acttctgcaa     8280

ggtcaatgag agaggagagt acttctggga gaagagggtc acaggctgcc caccctttga     8340

tgaacacaag tgtctggctg agggaggtaa aattatgaaa attccaggca cctgctgtga     8400

cacatgtgag gagcctgagt gcaacgacat cactgccagg ctgcagtatg tcaaggtggg     8460

aagctgtaag tctgaagtag aggtggatat ccactactgc cagggcaaat gtgccagcaa     8520

agccatgtac tccattgaca tcaacgatgt gcaggaccag tgctcctgct gctctccgac     8580

acggacggag cccatgcagg tggccctgca ctgcaccaat ggctctgttg tgtaccatga     8640

ggttctcaat gccatggagt gcaaatgctc ccccaggaag tgcagcaagt gaggctgctg     8700

cagctgcatg ggtgcctgct gctgcctgcc ttggcctgat ggccaggcca gagtgctgcc     8760

agtcctctgc atgttctgct cttgtgccct tctgagccca caataaaggc tgagctctta     8820

tcttgcaaaa ggc                                                        8833


<210>  31
<211>  763
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  sequence

<400>  31

Met Ile Pro Ala Arg Phe Ala Gly Val Leu Leu Ala Leu Ala Leu Ile 
1               5                   10                  15      


Leu Pro Gly Thr Leu Cys Ala Glu Gly Thr Arg Gly Arg Ser Ser Thr 
            20                  25                  30          


Ala Arg Cys Ser Leu Phe Gly Ser Asp Phe Val Asn Thr Phe Asp Gly 
        35                  40                  45              


Ser Met Tyr Ser Phe Ala Gly Tyr Cys Ser Tyr Leu Leu Ala Gly Gly 
    50                  55                  60                  


Cys Gln Lys Arg Ser Phe Ser Ile Ile Gly Asp Phe Gln Asn Gly Lys 
65                  70                  75                  80  


Arg Val Ser Leu Ser Val Tyr Leu Gly Glu Phe Phe Asp Ile His Leu 
                85                  90                  95      


Phe Val Asn Gly Thr Val Thr Gln Gly Asp Gln Arg Val Ser Met Pro 
            100                 105                 110         


Tyr Ala Ser Lys Gly Leu Tyr Leu Glu Thr Glu Ala Gly Tyr Tyr Lys 
        115                 120                 125             


Leu Ser Gly Glu Ala Tyr Gly Phe Val Ala Arg Ile Asp Gly Ser Gly 
    130                 135                 140                 


Asn Phe Gln Val Leu Leu Ser Asp Arg Tyr Phe Asn Lys Thr Cys Gly 
145                 150                 155                 160 


Leu Cys Gly Asn Phe Asn Ile Phe Ala Glu Asp Asp Phe Met Thr Gln 
                165                 170                 175     


Glu Gly Thr Leu Thr Ser Asp Pro Tyr Asp Phe Ala Asn Ser Trp Ala 
            180                 185                 190         


Leu Ser Ser Gly Glu Gln Trp Cys Glu Arg Ala Ser Pro Pro Ser Ser 
        195                 200                 205             


Ser Cys Asn Ile Ser Ser Gly Glu Met Gln Lys Gly Leu Trp Glu Gln 
    210                 215                 220                 


Cys Gln Leu Leu Lys Ser Thr Ser Val Phe Ala Arg Cys His Pro Leu 
225                 230                 235                 240 


Val Asp Pro Glu Pro Phe Val Ala Leu Cys Glu Lys Thr Leu Cys Glu 
                245                 250                 255     


Cys Ala Gly Gly Leu Glu Cys Ala Cys Pro Ala Leu Leu Glu Tyr Ala 
            260                 265                 270         


Arg Thr Cys Ala Gln Glu Gly Met Val Leu Tyr Gly Trp Thr Asp His 
        275                 280                 285             


Ser Ala Cys Ser Pro Val Cys Pro Ala Gly Met Glu Tyr Arg Gln Cys 
    290                 295                 300                 


Val Ser Pro Cys Ala Arg Thr Cys Gln Ser Leu His Ile Asn Glu Met 
305                 310                 315                 320 


Cys Gln Glu Arg Cys Val Asp Gly Cys Ser Cys Pro Glu Gly Gln Leu 
                325                 330                 335     


Leu Asp Glu Gly Leu Cys Val Glu Ser Thr Glu Cys Pro Cys Val His 
            340                 345                 350         


Ser Gly Lys Arg Tyr Pro Pro Gly Thr Ser Leu Ser Arg Asp Cys Asn 
        355                 360                 365             


Thr Cys Ile Cys Arg Asn Ser Gln Trp Ile Cys Ser Asn Glu Glu Cys 
    370                 375                 380                 


Pro Gly Glu Cys Leu Val Thr Gly Gln Ser His Phe Lys Ser Phe Asp 
385                 390                 395                 400 


Asn Arg Tyr Phe Thr Phe Ser Gly Ile Cys Gln Tyr Leu Leu Ala Arg 
                405                 410                 415     


Asp Cys Gln Asp His Ser Phe Ser Ile Val Ile Glu Thr Val Gln Cys 
            420                 425                 430         


Ala Asp Asp Arg Asp Ala Val Cys Thr Arg Ser Val Thr Val Arg Leu 
        435                 440                 445             


Pro Gly Leu His Asn Ser Leu Val Lys Leu Lys His Gly Ala Gly Val 
    450                 455                 460                 


Ala Met Asp Gly Gln Asp Ile Gln Leu Pro Leu Leu Lys Gly Asp Leu 
465                 470                 475                 480 


Arg Ile Gln His Thr Val Thr Ala Ser Val Arg Leu Ser Tyr Gly Glu 
                485                 490                 495     


Asp Leu Gln Met Asp Trp Asp Gly Arg Gly Arg Leu Leu Val Lys Leu 
            500                 505                 510         


Ser Pro Val Tyr Ala Gly Lys Thr Cys Gly Leu Cys Gly Asn Tyr Asn 
        515                 520                 525             


Gly Asn Gln Gly Asp Asp Phe Leu Thr Pro Ser Gly Leu Ala Glu Pro 
    530                 535                 540                 


Arg Val Glu Asp Phe Gly Asn Ala Trp Lys Leu His Gly Asp Cys Gln 
545                 550                 555                 560 


Asp Leu Gln Lys Gln His Ser Asp Pro Cys Ala Leu Asn Pro Arg Met 
                565                 570                 575     


Thr Arg Phe Ser Glu Glu Ala Cys Ala Val Leu Thr Ser Pro Thr Phe 
            580                 585                 590         


Glu Ala Cys His Arg Ala Val Ser Pro Leu Pro Tyr Leu Arg Asn Cys 
        595                 600                 605             


Arg Tyr Asp Val Cys Ser Cys Ser Asp Gly Arg Glu Cys Leu Cys Gly 
    610                 615                 620                 


Ala Leu Ala Ser Tyr Ala Ala Ala Cys Ala Gly Arg Gly Val Arg Val 
625                 630                 635                 640 


Ala Trp Arg Glu Pro Gly Arg Cys Glu Leu Asn Cys Pro Lys Gly Gln 
                645                 650                 655     


Val Tyr Leu Gln Cys Gly Thr Pro Cys Asn Leu Thr Cys Arg Ser Leu 
            660                 665                 670         


Ser Tyr Pro Asp Glu Glu Cys Asn Glu Ala Cys Leu Glu Gly Cys Phe 
        675                 680                 685             


Cys Pro Pro Gly Leu Tyr Met Asp Glu Arg Gly Asp Cys Val Pro Lys 
    690                 695                 700                 


Ala Gln Cys Pro Cys Tyr Tyr Asp Gly Glu Ile Phe Gln Pro Glu Asp 
705                 710                 715                 720 


Ile Phe Ser Asp His His Thr Met Cys Tyr Cys Glu Asp Gly Phe Met 
                725                 730                 735     


His Cys Thr Met Ser Gly Val Pro Gly Ser Leu Leu Pro Asp Ala Val 
            740                 745                 750         


Leu Ser Ser Pro Leu Ser His Arg Ser Lys Arg 
        755                 760             


<210>  32
<211>  2289
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  sequence

<400>  32
atgatccccg ccagattcgc cggcgtgctg ctggccctgg ccctgatcct gcccggcacc       60

ctgtgcgccg agggcaccag aggcagatcc agcaccgccc ggtgcagcct gttcggcagc      120

gacttcgtga acaccttcga cggcagcatg tacagcttcg ccggctactg tagctacctg      180

ctggctggcg gctgccagaa gcggagcttc agcatcatcg gcgacttcca gaacggcaag      240

cgggtgtccc tgagcgtgta cctgggcgag ttcttcgaca tccacctgtt cgtgaacggc      300

accgtgaccc agggcgatca gagggtgtcc atgccctacg ccagcaaggg cctgtacctg      360

gaaaccgagg ccggctacta caagctgtcc ggcgaggcct acggcttcgt ggcccggatc      420

gacggctccg gcaacttcca ggtgctgctg tccgaccggt acttcaacaa gacctgcggc      480

ctgtgcggca acttcaacat cttcgccgag gacgacttca tgacccagga aggcaccctg      540

accagcgacc cctacgactt cgccaacagc tgggccctga gcagcggcga gcagtggtgc      600

gagagagcca gcccccccag cagcagctgc aacatcagct ccggcgagat gcagaaaggc      660

ctgtgggagc agtgccagct gctgaagtcc acctccgtgt tcgcccggtg ccaccccctg      720

gtggaccccg agccctttgt ggccctgtgc gaaaagaccc tgtgcgagtg cgctggcggc      780

ctggaatgcg cctgccctgc cctgctggaa tacgcccgga cctgcgccca agaagggatg      840

gtcctgtacg gctggaccga ccacagcgcc tgcagccccg tctgccctgc cggcatggaa      900

taccggcagt gcgtgagccc ctgcgccaga acctgccaga gcctgcacat caacgagatg      960

tgccaggaaa gatgcgtcga cggctgctct tgtcccgagg gacagctcct ggacgagggc     1020

ctctgcgtgg agagcaccga gtgcccctgc gtgcacagcg gcaagagata cccccctggc     1080

accagcctga gccgggactg caacacctgc atttgccgga acagccagtg gatctgcagc     1140

aacgaggaat gcccaggcga gtgcctggtc accggccaga gccacttcaa gagcttcgac     1200

aacagatact tcaccttcag cggcatctgc cagtatctgc tggccagaga ctgccaggac     1260

cacagcttct ccatcgtgat cgagacagtg cagtgcgccg acgaccggga cgccgtgtgc     1320

accagatccg tgaccgtgag actgcccggc ctgcacaaca gcctggtcaa gctgaagcat     1380

ggcgctggcg tggccatgga cggccaggac gtgcagctgc ctctgctgaa gggcgacctg     1440

cggatccagc acaccgtgac cgccagcgtg agactgtcct acggcgagga cctgcagatg     1500

gactgggacg gcagaggccg gctgctcgtg aagctgtccc ccgtgtacgc cggcaagaca     1560

tgtggcctgt gtgggaacta caacggcaac cagggcgacg actttctgac ccccagcggc     1620

ctggccgagc ccagagtgga ggacttcggc aacgcctgga agctgcacgg cgattgccag     1680

gatctgcaga aacagcactc cgacccctgc gccctgaacc cccggatgac ccggttcagc     1740

gaagaggctt gcgccgtgct gaccagcccc accttcgagg cctgccaccg ggccgtgagc     1800

cccctgccct acctgcggaa ctgcagatac gatgtgtgta gctgctctga cggccgggag     1860

tgcctgtgtg gcgccctggc cagctatgcc gctgcctgcg ccggacgcgg tgtgagagtg     1920

gcttggcggg agcctggcag atgcgagctg aactgcccca agggccaggt gtacctgcag     1980

tgcggcaccc cctgcaacct gacctgccgg tccctgagct accccgacga agagtgcaac     2040

gaggcctgtc tcgaaggctg cttctgcccc cctggcctgt acatggacga gcggggcgac     2100

tgcgtgccca aggcccagtg cccctgttac tacgacggcg agatcttcca gcccgaggac     2160

atcttcagcg accaccacac catgtgctac tgcgaggacg gctttatgca ctgcaccatg     2220

agcggcgtgc ccggcagcct gctgccagac gccgtgctgt cctcccccct gagccaccgg     2280

tccaagcgg                                                             2289


<210>  33
<211>  506
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  sequence

<400>  33

Met Ile Pro Ala Arg Phe Ala Gly Val Leu Leu Ala Leu Ala Leu Ile 
1               5                   10                  15      


Leu Pro Gly Thr Leu Cys Ser Leu Ser Cys Arg Pro Pro Met Val Lys 
            20                  25                  30          


Leu Val Cys Pro Ala Asp Asn Leu Arg Ala Glu Gly Leu Glu Cys Thr 
        35                  40                  45              


Lys Thr Cys Gln Asn Tyr Asp Leu Glu Cys Met Ser Met Gly Cys Val 
    50                  55                  60                  


Ser Gly Cys Leu Cys Pro Pro Gly Met Val Arg His Glu Asn Arg Cys 
65                  70                  75                  80  


Val Ala Leu Glu Arg Cys Pro Cys Phe His Gln Gly Lys Glu Tyr Ala 
                85                  90                  95      


Pro Gly Glu Thr Val Lys Ile Gly Cys Asn Thr Cys Val Cys Arg Asp 
            100                 105                 110         


Arg Lys Trp Asn Cys Thr Asp His Val Cys Asp Ala Thr Cys Ser Thr 
        115                 120                 125             


Ile Gly Met Ala His Tyr Leu Thr Phe Asp Gly Leu Lys Tyr Leu Phe 
    130                 135                 140                 


Pro Gly Glu Cys Gln Tyr Val Leu Val Gln Asp Tyr Cys Gly Ser Asn 
145                 150                 155                 160 


Pro Gly Thr Phe Arg Ile Leu Val Gly Asn Lys Gly Cys Ser His Pro 
                165                 170                 175     


Ser Val Lys Cys Lys Lys Arg Val Thr Ile Leu Val Glu Gly Gly Glu 
            180                 185                 190         


Ile Glu Leu Phe Asp Gly Glu Val Asn Val Lys Arg Pro Met Lys Asp 
        195                 200                 205             


Glu Thr His Phe Glu Val Val Glu Ser Gly Arg Tyr Ile Ile Leu Leu 
    210                 215                 220                 


Leu Gly Lys Ala Leu Ser Val Val Trp Asp Arg His Leu Ser Ile Ser 
225                 230                 235                 240 


Val Val Leu Lys Gln Thr Tyr Gln Glu Lys Val Cys Gly Leu Cys Gly 
                245                 250                 255     


Asn Phe Asp Gly Ile Gln Asn Asn Asp Leu Thr Ser Ser Asn Leu Gln 
            260                 265                 270         


Val Glu Glu Asp Pro Val Asp Phe Gly Asn Ser Trp Lys Val Ser Ser 
        275                 280                 285             


Gln Cys Ala Asp Thr Arg Lys Val Pro Leu Asp Ser Ser Pro Ala Thr 
    290                 295                 300                 


Cys His Asn Asn Ile Met Lys Gln Thr Met Val Asp Ser Ser Cys Arg 
305                 310                 315                 320 


Ile Leu Thr Ser Asp Val Phe Gln Asp Cys Asn Lys Leu Val Asp Pro 
                325                 330                 335     


Glu Pro Tyr Leu Asp Val Cys Ile Tyr Asp Thr Cys Ser Cys Glu Ser 
            340                 345                 350         


Ile Gly Asp Cys Ala Cys Phe Cys Asp Thr Ile Ala Ala Tyr Ala His 
        355                 360                 365             


Val Cys Ala Gln His Gly Lys Val Val Thr Trp Arg Thr Ala Thr Leu 
    370                 375                 380                 


Cys Pro Gln Ser Cys Glu Glu Arg Asn Leu Arg Glu Asn Gly Tyr Glu 
385                 390                 395                 400 


Cys Glu Trp Arg Tyr Asn Ser Cys Ala Pro Ala Cys Gln Val Thr Cys 
                405                 410                 415     


Gln His Pro Glu Pro Leu Ala Cys Pro Val Gln Cys Val Glu Gly Cys 
            420                 425                 430         


His Ala His Cys Pro Pro Gly Lys Ile Leu Asp Glu Leu Leu Gln Thr 
        435                 440                 445             


Cys Val Asp Pro Glu Asp Cys Pro Val Cys Glu Val Ala Gly Arg Arg 
    450                 455                 460                 


Phe Ala Ser Gly Lys Lys Val Thr Leu Asn Pro Ser Asp Pro Glu His 
465                 470                 475                 480 


Cys Gln Ile Cys His Cys Asp Val Val Asn Leu Thr Cys Glu Ala Cys 
                485                 490                 495     


Gln Glu Pro Gly Gly Leu Val Val Pro Pro 
            500                 505     


<210>  34
<211>  740
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  sequence

<400>  34

Met Ile Pro Ala Arg Phe Ala Gly Val Leu Leu Ala Leu Ala Leu Ile 
1               5                   10                  15      


Leu Pro Gly Thr Leu Cys Ser Leu Ser Cys Arg Pro Pro Met Val Lys 
            20                  25                  30          


Leu Val Cys Pro Ala Asp Asn Leu Arg Ala Glu Gly Leu Glu Cys Thr 
        35                  40                  45              


Lys Thr Cys Gln Asn Tyr Asp Leu Glu Cys Met Ser Met Gly Cys Val 
    50                  55                  60                  


Ser Gly Cys Leu Cys Pro Pro Gly Met Val Arg His Glu Asn Arg Cys 
65                  70                  75                  80  


Val Ala Leu Glu Arg Cys Pro Cys Phe His Gln Gly Lys Glu Tyr Ala 
                85                  90                  95      


Pro Gly Glu Thr Val Lys Ile Gly Cys Asn Thr Cys Val Cys Arg Asp 
            100                 105                 110         


Arg Lys Trp Asn Cys Thr Asp His Val Cys Asp Ala Thr Cys Ser Thr 
        115                 120                 125             


Ile Gly Met Ala His Tyr Leu Thr Phe Asp Gly Leu Lys Tyr Leu Phe 
    130                 135                 140                 


Pro Gly Glu Cys Gln Tyr Val Leu Val Gln Asp Tyr Cys Gly Ser Asn 
145                 150                 155                 160 


Pro Gly Thr Phe Arg Ile Leu Val Gly Asn Lys Gly Cys Ser His Pro 
                165                 170                 175     


Ser Val Lys Cys Lys Lys Arg Val Thr Ile Leu Val Glu Gly Gly Glu 
            180                 185                 190         


Ile Glu Leu Phe Asp Gly Glu Val Asn Val Lys Arg Pro Met Lys Asp 
        195                 200                 205             


Glu Thr His Phe Glu Val Val Glu Ser Gly Arg Tyr Ile Ile Leu Leu 
    210                 215                 220                 


Leu Gly Lys Ala Leu Ser Val Val Trp Asp Arg His Leu Ser Ile Ser 
225                 230                 235                 240 


Val Val Leu Lys Gln Thr Tyr Gln Glu Lys Val Cys Gly Leu Cys Gly 
                245                 250                 255     


Asn Phe Asp Gly Ile Gln Asn Asn Asp Leu Thr Ser Ser Asn Leu Gln 
            260                 265                 270         


Val Glu Glu Asp Pro Val Asp Phe Gly Asn Ser Trp Lys Val Ser Ser 
        275                 280                 285             


Gln Cys Ala Asp Thr Arg Lys Val Pro Leu Asp Ser Ser Pro Ala Thr 
    290                 295                 300                 


Cys His Asn Asn Ile Met Lys Gln Thr Met Val Asp Ser Ser Cys Arg 
305                 310                 315                 320 


Ile Leu Thr Ser Asp Val Phe Gln Asp Cys Asn Lys Leu Val Asp Pro 
                325                 330                 335     


Glu Pro Tyr Leu Asp Val Cys Ile Tyr Asp Thr Cys Ser Cys Glu Ser 
            340                 345                 350         


Ile Gly Asp Cys Ala Cys Phe Cys Asp Thr Ile Ala Ala Tyr Ala His 
        355                 360                 365             


Val Cys Ala Gln His Gly Lys Val Val Thr Trp Arg Thr Ala Thr Leu 
    370                 375                 380                 


Cys Pro Gln Ser Cys Glu Glu Arg Asn Leu Arg Glu Asn Gly Tyr Glu 
385                 390                 395                 400 


Cys Glu Trp Arg Tyr Asn Ser Cys Ala Pro Ala Cys Gln Val Thr Cys 
                405                 410                 415     


Gln His Pro Glu Pro Leu Ala Cys Pro Val Gln Cys Val Glu Gly Cys 
            420                 425                 430         


His Ala His Cys Pro Pro Gly Lys Ile Leu Asp Glu Leu Leu Gln Thr 
        435                 440                 445             


Cys Val Asp Pro Glu Asp Cys Pro Val Cys Glu Val Ala Gly Arg Arg 
    450                 455                 460                 


Phe Ala Ser Gly Lys Lys Val Thr Leu Asn Pro Ser Asp Pro Glu His 
465                 470                 475                 480 


Cys Gln Ile Cys His Cys Asp Val Val Asn Leu Thr Cys Glu Ala Cys 
                485                 490                 495     


Gln Glu Pro Gly Gly Leu Val Val Pro Pro Thr Asp Ala Pro Val Ser 
            500                 505                 510         


Pro Thr Thr Leu Tyr Val Glu Asp Ile Ser Glu Pro Pro Leu His Asp 
        515                 520                 525             


Phe Tyr Cys Ser Arg Leu Leu Asp Leu Val Phe Leu Leu Asp Gly Ser 
    530                 535                 540                 


Ser Arg Leu Ser Glu Ala Glu Phe Glu Val Leu Lys Ala Phe Val Val 
545                 550                 555                 560 


Asp Met Met Glu Arg Leu Arg Ile Ser Gln Lys Trp Val Arg Val Ala 
                565                 570                 575     


Val Val Glu Tyr His Asp Gly Ser His Ala Tyr Ile Gly Leu Lys Asp 
            580                 585                 590         


Arg Lys Arg Pro Ser Glu Leu Arg Arg Ile Ala Ser Gln Val Lys Tyr 
        595                 600                 605             


Ala Gly Ser Gln Val Ala Ser Thr Ser Glu Val Leu Lys Tyr Thr Leu 
    610                 615                 620                 


Phe Gln Ile Phe Ser Lys Ile Asp Arg Pro Glu Ala Ser Arg Ile Ala 
625                 630                 635                 640 


Leu Leu Leu Met Ala Ser Gln Glu Pro Gln Arg Met Ser Arg Asn Phe 
                645                 650                 655     


Val Arg Tyr Val Gln Gly Leu Lys Lys Lys Lys Val Ile Val Ile Pro 
            660                 665                 670         


Val Gly Ile Gly Pro His Ala Asn Leu Lys Gln Ile Arg Leu Ile Glu 
        675                 680                 685             


Lys Gln Ala Pro Glu Asn Lys Ala Phe Val Leu Ser Ser Val Asp Glu 
    690                 695                 700                 


Leu Glu Gln Gln Arg Asp Glu Ile Val Ser Tyr Leu Cys Asp Leu Ala 
705                 710                 715                 720 


Pro Glu Ala Pro Pro Pro Thr Leu Pro Pro His Met Ala Gln Val Thr 
                725                 730                 735     


Val Gly Pro Gly 
            740 


<210>  35
<211>  1138
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  sequence

<400>  35

Met Ile Pro Ala Arg Phe Ala Gly Val Leu Leu Ala Leu Ala Leu Ile 
1               5                   10                  15      


Leu Pro Gly Thr Leu Cys Ser Leu Ser Cys Arg Pro Pro Met Val Lys 
            20                  25                  30          


Leu Val Cys Pro Ala Asp Asn Leu Arg Ala Glu Gly Leu Glu Cys Thr 
        35                  40                  45              


Lys Thr Cys Gln Asn Tyr Asp Leu Glu Cys Met Ser Met Gly Cys Val 
    50                  55                  60                  


Ser Gly Cys Leu Cys Pro Pro Gly Met Val Arg His Glu Asn Arg Cys 
65                  70                  75                  80  


Val Ala Leu Glu Arg Cys Pro Cys Phe His Gln Gly Lys Glu Tyr Ala 
                85                  90                  95      


Pro Gly Glu Thr Val Lys Ile Gly Cys Asn Thr Cys Val Cys Arg Asp 
            100                 105                 110         


Arg Lys Trp Asn Cys Thr Asp His Val Cys Asp Ala Thr Cys Ser Thr 
        115                 120                 125             


Ile Gly Met Ala His Tyr Leu Thr Phe Asp Gly Leu Lys Tyr Leu Phe 
    130                 135                 140                 


Pro Gly Glu Cys Gln Tyr Val Leu Val Gln Asp Tyr Cys Gly Ser Asn 
145                 150                 155                 160 


Pro Gly Thr Phe Arg Ile Leu Val Gly Asn Lys Gly Cys Ser His Pro 
                165                 170                 175     


Ser Val Lys Cys Lys Lys Arg Val Thr Ile Leu Val Glu Gly Gly Glu 
            180                 185                 190         


Ile Glu Leu Phe Asp Gly Glu Val Asn Val Lys Arg Pro Met Lys Asp 
        195                 200                 205             


Glu Thr His Phe Glu Val Val Glu Ser Gly Arg Tyr Ile Ile Leu Leu 
    210                 215                 220                 


Leu Gly Lys Ala Leu Ser Val Val Trp Asp Arg His Leu Ser Ile Ser 
225                 230                 235                 240 


Val Val Leu Lys Gln Thr Tyr Gln Glu Lys Val Cys Gly Leu Cys Gly 
                245                 250                 255     


Asn Phe Asp Gly Ile Gln Asn Asn Asp Leu Thr Ser Ser Asn Leu Gln 
            260                 265                 270         


Val Glu Glu Asp Pro Val Asp Phe Gly Asn Ser Trp Lys Val Ser Ser 
        275                 280                 285             


Gln Cys Ala Asp Thr Arg Lys Val Pro Leu Asp Ser Ser Pro Ala Thr 
    290                 295                 300                 


Cys His Asn Asn Ile Met Lys Gln Thr Met Val Asp Ser Ser Cys Arg 
305                 310                 315                 320 


Ile Leu Thr Ser Asp Val Phe Gln Asp Cys Asn Lys Leu Val Asp Pro 
                325                 330                 335     


Glu Pro Tyr Leu Asp Val Cys Ile Tyr Asp Thr Cys Ser Cys Glu Ser 
            340                 345                 350         


Ile Gly Asp Cys Ala Cys Phe Cys Asp Thr Ile Ala Ala Tyr Ala His 
        355                 360                 365             


Val Cys Ala Gln His Gly Lys Val Val Thr Trp Arg Thr Ala Thr Leu 
    370                 375                 380                 


Cys Pro Gln Ser Cys Glu Glu Arg Asn Leu Arg Glu Asn Gly Tyr Glu 
385                 390                 395                 400 


Cys Glu Trp Arg Tyr Asn Ser Cys Ala Pro Ala Cys Gln Val Thr Cys 
                405                 410                 415     


Gln His Pro Glu Pro Leu Ala Cys Pro Val Gln Cys Val Glu Gly Cys 
            420                 425                 430         


His Ala His Cys Pro Pro Gly Lys Ile Leu Asp Glu Leu Leu Gln Thr 
        435                 440                 445             


Cys Val Asp Pro Glu Asp Cys Pro Val Cys Glu Val Ala Gly Arg Arg 
    450                 455                 460                 


Phe Ala Ser Gly Lys Lys Val Thr Leu Asn Pro Ser Asp Pro Glu His 
465                 470                 475                 480 


Cys Gln Ile Cys His Cys Asp Val Val Asn Leu Thr Cys Glu Ala Cys 
                485                 490                 495     


Gln Glu Pro Gly Gly Leu Val Val Pro Pro Thr Asp Ala Pro Val Ser 
            500                 505                 510         


Pro Thr Thr Leu Tyr Val Glu Asp Ile Ser Glu Pro Pro Leu His Asp 
        515                 520                 525             


Phe Tyr Cys Ser Arg Leu Leu Asp Leu Val Phe Leu Leu Asp Gly Ser 
    530                 535                 540                 


Ser Arg Leu Ser Glu Ala Glu Phe Glu Val Leu Lys Ala Phe Val Val 
545                 550                 555                 560 


Asp Met Met Glu Arg Leu Arg Ile Ser Gln Lys Trp Val Arg Val Ala 
                565                 570                 575     


Val Val Glu Tyr His Asp Gly Ser His Ala Tyr Ile Gly Leu Lys Asp 
            580                 585                 590         


Arg Lys Arg Pro Ser Glu Leu Arg Arg Ile Ala Ser Gln Val Lys Tyr 
        595                 600                 605             


Ala Gly Ser Gln Val Ala Ser Thr Ser Glu Val Leu Lys Tyr Thr Leu 
    610                 615                 620                 


Phe Gln Ile Phe Ser Lys Ile Asp Arg Pro Glu Ala Ser Arg Ile Ala 
625                 630                 635                 640 


Leu Leu Leu Met Ala Ser Gln Glu Pro Gln Arg Met Ser Arg Asn Phe 
                645                 650                 655     


Val Arg Tyr Val Gln Gly Leu Lys Lys Lys Lys Val Ile Val Ile Pro 
            660                 665                 670         


Val Gly Ile Gly Pro His Ala Asn Leu Lys Gln Ile Arg Leu Ile Glu 
        675                 680                 685             


Lys Gln Ala Pro Glu Asn Lys Ala Phe Val Leu Ser Ser Val Asp Glu 
    690                 695                 700                 


Leu Glu Gln Gln Arg Asp Glu Ile Val Ser Tyr Leu Cys Asp Leu Ala 
705                 710                 715                 720 


Pro Glu Ala Pro Pro Pro Thr Leu Pro Pro His Met Ala Gln Val Thr 
                725                 730                 735     


Val Gly Pro Gly Leu Leu Gly Val Ser Thr Leu Gly Pro Lys Arg Asn 
            740                 745                 750         


Ser Met Val Leu Asp Val Ala Phe Val Leu Glu Gly Ser Asp Lys Ile 
        755                 760                 765             


Gly Glu Ala Asp Phe Asn Arg Ser Lys Glu Phe Met Glu Glu Val Ile 
    770                 775                 780                 


Gln Arg Met Asp Val Gly Gln Asp Ser Ile His Val Thr Val Leu Gln 
785                 790                 795                 800 


Tyr Ser Tyr Met Val Thr Val Glu Tyr Pro Phe Ser Glu Ala Gln Ser 
                805                 810                 815     


Lys Gly Asp Ile Leu Gln Arg Val Arg Glu Ile Arg Tyr Gln Gly Gly 
            820                 825                 830         


Asn Arg Thr Asn Thr Gly Leu Ala Leu Arg Tyr Leu Ser Asp His Ser 
        835                 840                 845             


Phe Leu Val Ser Gln Gly Asp Arg Glu Gln Ala Pro Asn Leu Val Tyr 
    850                 855                 860                 


Met Val Thr Gly Asn Pro Ala Ser Asp Glu Ile Lys Arg Leu Pro Gly 
865                 870                 875                 880 


Asp Ile Gln Val Val Pro Ile Gly Val Gly Pro Asn Ala Asn Val Gln 
                885                 890                 895     


Glu Leu Glu Arg Ile Gly Trp Pro Asn Ala Pro Ile Leu Ile Gln Asp 
            900                 905                 910         


Phe Glu Thr Leu Pro Arg Glu Ala Pro Asp Leu Val Leu Gln Arg Cys 
        915                 920                 925             


Cys Ser Gly Glu Gly Leu Gln Ile Pro Thr Leu Ser Pro Ala Pro Asp 
    930                 935                 940                 


Cys Ser Gln Pro Leu Asp Val Ile Leu Leu Leu Asp Gly Ser Ser Ser 
945                 950                 955                 960 


Phe Pro Ala Ser Tyr Phe Asp Glu Met Lys Ser Phe Ala Lys Ala Phe 
                965                 970                 975     


Ile Ser Lys Ala Asn Ile Gly Pro Arg Leu Thr Gln Val Ser Val Leu 
            980                 985                 990         


Gln Tyr Gly Ser Ile Thr Thr Ile  Asp Val Pro Trp Asn  Val Val Pro 
        995                 1000                 1005             


Glu Lys  Ala His Leu Leu Ser  Leu Val Asp Val Met  Gln Arg Glu 
    1010                 1015                 1020             


Gly Gly  Pro Ser Gln Ile Gly  Asp Ala Leu Gly Phe  Ala Val Arg 
    1025                 1030                 1035             


Tyr Leu  Thr Ser Glu Met His  Gly Ala Arg Pro Gly  Ala Ser Lys 
    1040                 1045                 1050             


Ala Val  Val Ile Leu Val Thr  Asp Val Ser Val Asp  Ser Val Asp 
    1055                 1060                 1065             


Ala Ala  Ala Asp Ala Ala Arg  Ser Asn Arg Val Thr  Val Phe Pro 
    1070                 1075                 1080             


Ile Gly  Ile Gly Asp Arg Tyr  Asp Ala Ala Gln Leu  Arg Ile Leu 
    1085                 1090                 1095             


Ala Gly  Pro Ala Gly Asp Ser  Asn Val Val Lys Leu  Gln Arg Ile 
    1100                 1105                 1110             


Glu Asp  Leu Pro Thr Met Val  Thr Leu Gly Asn Ser  Phe Leu His 
    1115                 1120                 1125             


Lys Leu  Cys Ser Gly Phe Val  Arg Ile Cys 
    1130                 1135             


<210>  36
<211>  733
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  sequence

<400>  36

Met Ile Pro Ala Arg Phe Ala Gly Val Leu Leu Ala Leu Ala Leu Ile 
1               5                   10                  15      


Leu Pro Gly Thr Leu Cys Ser Leu Ser Cys Arg Pro Pro Met Val Lys 
            20                  25                  30          


Leu Val Cys Pro Ala Asp Asn Leu Arg Ala Glu Gly Leu Glu Cys Thr 
        35                  40                  45              


Lys Thr Cys Gln Asn Tyr Asp Leu Glu Cys Met Ser Met Gly Cys Val 
    50                  55                  60                  


Ser Gly Cys Leu Cys Pro Pro Gly Met Val Arg His Glu Asn Arg Cys 
65                  70                  75                  80  


Val Ala Leu Glu Arg Cys Pro Cys Phe His Gln Gly Lys Glu Tyr Ala 
                85                  90                  95      


Pro Gly Glu Thr Val Lys Ile Gly Cys Asn Thr Cys Val Cys Arg Asp 
            100                 105                 110         


Arg Lys Trp Asn Cys Thr Asp His Val Cys Asp Ala Thr Cys Ser Thr 
        115                 120                 125             


Ile Gly Met Ala His Tyr Leu Thr Phe Asp Gly Leu Lys Tyr Leu Phe 
    130                 135                 140                 


Pro Gly Glu Cys Gln Tyr Val Leu Val Gln Asp Tyr Cys Gly Ser Asn 
145                 150                 155                 160 


Pro Gly Thr Phe Arg Ile Leu Val Gly Asn Lys Gly Cys Ser His Pro 
                165                 170                 175     


Ser Val Lys Cys Lys Lys Arg Val Thr Ile Leu Val Glu Gly Gly Glu 
            180                 185                 190         


Ile Glu Leu Phe Asp Gly Glu Val Asn Val Lys Arg Pro Met Lys Asp 
        195                 200                 205             


Glu Thr His Phe Glu Val Val Glu Ser Gly Arg Tyr Ile Ile Leu Leu 
    210                 215                 220                 


Leu Gly Lys Ala Leu Ser Val Val Trp Asp Arg His Leu Ser Ile Ser 
225                 230                 235                 240 


Val Val Leu Lys Gln Thr Tyr Gln Glu Lys Val Cys Gly Leu Cys Gly 
                245                 250                 255     


Asn Phe Asp Gly Ile Gln Asn Asn Asp Leu Thr Ser Ser Asn Leu Gln 
            260                 265                 270         


Val Glu Glu Asp Pro Val Asp Phe Gly Asn Ser Trp Lys Val Ser Ser 
        275                 280                 285             


Gln Cys Ala Asp Thr Arg Lys Val Pro Leu Asp Ser Ser Pro Ala Thr 
    290                 295                 300                 


Cys His Asn Asn Ile Met Lys Gln Thr Met Val Asp Ser Ser Cys Arg 
305                 310                 315                 320 


Ile Leu Thr Ser Asp Val Phe Gln Asp Cys Asn Lys Leu Val Asp Pro 
                325                 330                 335     


Glu Pro Tyr Leu Asp Val Cys Ile Tyr Asp Thr Cys Ser Cys Glu Ser 
            340                 345                 350         


Ile Gly Asp Cys Ala Cys Phe Cys Asp Thr Ile Ala Ala Tyr Ala His 
        355                 360                 365             


Val Cys Ala Gln His Gly Lys Val Val Thr Trp Arg Thr Ala Thr Leu 
    370                 375                 380                 


Cys Pro Gln Ser Cys Glu Glu Arg Asn Leu Arg Glu Asn Gly Tyr Glu 
385                 390                 395                 400 


Cys Glu Trp Arg Tyr Asn Ser Cys Ala Pro Ala Cys Gln Val Thr Cys 
                405                 410                 415     


Gln His Pro Glu Pro Leu Ala Cys Pro Val Gln Cys Val Glu Gly Cys 
            420                 425                 430         


His Ala His Cys Pro Pro Gly Lys Ile Leu Asp Glu Leu Leu Gln Thr 
        435                 440                 445             


Cys Val Asp Pro Glu Asp Cys Pro Val Cys Glu Val Ala Gly Arg Arg 
    450                 455                 460                 


Phe Ala Ser Gly Lys Lys Val Thr Leu Asn Pro Ser Asp Pro Glu His 
465                 470                 475                 480 


Cys Gln Ile Cys His Cys Asp Val Val Asn Leu Thr Cys Glu Ala Cys 
                485                 490                 495     


Gln Glu Pro Gly Gly Leu Val Val Pro Pro Asp Lys Thr His Thr Cys 
            500                 505                 510         


Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu 
        515                 520                 525             


Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu 
    530                 535                 540                 


Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys 
545                 550                 555                 560 


Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys 
                565                 570                 575     


Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu 
            580                 585                 590         


Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys 
        595                 600                 605             


Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys 
    610                 615                 620                 


Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser 
625                 630                 635                 640 


Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys 
                645                 650                 655     


Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln 
            660                 665                 670         


Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly 
        675                 680                 685             


Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln 
    690                 695                 700                 


Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn 
705                 710                 715                 720 


His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
                725                 730             


<210>  37
<211>  2199
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  sequence

<400>  37
atgatccccg ccagattcgc cggcgtgctg ctggccctgg ccctgatcct gcccggcacc       60

ctgtgcagcc tgagctgcag accccccatg gtcaagctcg tgtgcccagc cgacaatctg      120

cgggccgagg ggctggaatg caccaagacc tgccagaact acgacctgga atgcatgagc      180

atgggctgcg tgagcggctg cctgtgccca cccggcatgg tccggcacga gaacagatgc      240

gtggccctgg aacggtgccc atgcttccac cagggcaaag agtacgcccc tggcgagaca      300

gtgaagatcg gctgcaatac ctgcgtgtgc cgggaccgga agtggaactg caccgaccac      360

gtgtgcgacg ccacatgcag caccatcggc atggcccact acctgacctt tgacggcctg      420

aagtacctgt tccccggcga gtgccagtac gtgctggtgc aggactactg cggcagcaac      480

cccggcacct tccggatcct cgtgggcaac aagggatgca gccaccccag cgtgaagtgc      540

aagaaacgcg tgaccatcct ggtggagggc ggcgagatcg agctgttcga cggcgaagtg      600

aacgtgaagc ggcccatgaa ggacgagaca cacttcgagg tggtggagag cggccggtac      660

atcatcctgc tgctgggcaa ggctctgagc gtcgtgtggg accggcacct gagcatcagc      720

gtggtgctga agcagaccta ccaggaaaaa gtctgcggcc tctgtggcaa tttcgacggc      780

atccagaaca acgatctgac cagcagcaac ctgcaggtgg aagaggaccc cgtggacttt      840

ggcaatagct ggaaggtgtc cagccagtgt gccgacacca gaaaagtgcc cctggactct      900

agccccgcca cctgccacaa caacatcatg aagcagacaa tggtggacag ctcctgccgg      960

atcctgacct ccgacgtgtt ccaggactgt aacaaactgg tggatcctga gccttacctg     1020

gacgtgtgca tctacgacac ctgcagctgc gagagcatcg gcgattgcgc ctgcttctgc     1080

gacacaatcg ccgcctacgc ccatgtgtgc gcccagcacg gcaaggtggt cacctggcgg     1140

accgcaaccc tgtgccccca gagctgcgag gaacggaacc tgcgggagaa cggctacgag     1200

tgcgagtggc ggtacaacag ctgcgcccca gcctgccagg tcacctgcca gcaccccgag     1260

cctctggcct gccccgtgca gtgcgtggag ggctgccacg cccactgccc tccaggcaag     1320

atcctggacg agctgctgca gacctgcgtg gaccctgagg actgccctgt gtgcgaggtg     1380

gccggcaggc ggttcgcctc cggcaagaaa gtgaccctga accctagcga ccccgagcac     1440

tgccagatct gccactgcga cgtggtcaat ctgacctgcg aggcttgcca ggaaccaggc     1500

ggcctcgtcg tgccccctga caaaactcac acatgcccac cgtgcccagc acctgaactc     1560

ctggggggac cgtcagtctt cctcttcccc ccaaaaccca aggacaccct catgatctcc     1620

cggacccctg aggtcacatg cgtggtggtg gacgtgagcc acgaagaccc tgaggtcaag     1680

ttcaactggt acgtggacgg cgtggaggtg cataatgcca agacaaagcc gcgggaggag     1740

cagtacaaca gcacgtaccg tgtggtcagc gtcctcaccg tcctgcacca ggactggctg     1800

aatggcaagg agtacaagtg caaggtctcc aacaaagccc tcccagcccc catcgagaaa     1860

accatctcca aagccaaagg gcagccccga gagccacagg tgtacaccct gcccccatcc     1920

cgggatgagc tgaccaagaa ccaggtcagc ctgacctgcc tggtcaaagg cttctatccc     1980

agcgacatcg ccgtggagtg ggagagcaat gggcagccgg agaacaacta caagaccacg     2040

cctcccgtgc tggactccga cggctccttc ttcctctaca gcaagctcac cgtggacaag     2100

agcaggtggc agcaggggaa cgtcttctca tgctccgtga tgcatgaggc tctgcacaac     2160

cactacacgc agaagagcct ctccctgtct ccgggtaaa                            2199


<210>  38
<211>  967
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  sequence

<400>  38

Met Ile Pro Ala Arg Phe Ala Gly Val Leu Leu Ala Leu Ala Leu Ile 
1               5                   10                  15      


Leu Pro Gly Thr Leu Cys Ser Leu Ser Cys Arg Pro Pro Met Val Lys 
            20                  25                  30          


Leu Val Cys Pro Ala Asp Asn Leu Arg Ala Glu Gly Leu Glu Cys Thr 
        35                  40                  45              


Lys Thr Cys Gln Asn Tyr Asp Leu Glu Cys Met Ser Met Gly Cys Val 
    50                  55                  60                  


Ser Gly Cys Leu Cys Pro Pro Gly Met Val Arg His Glu Asn Arg Cys 
65                  70                  75                  80  


Val Ala Leu Glu Arg Cys Pro Cys Phe His Gln Gly Lys Glu Tyr Ala 
                85                  90                  95      


Pro Gly Glu Thr Val Lys Ile Gly Cys Asn Thr Cys Val Cys Arg Asp 
            100                 105                 110         


Arg Lys Trp Asn Cys Thr Asp His Val Cys Asp Ala Thr Cys Ser Thr 
        115                 120                 125             


Ile Gly Met Ala His Tyr Leu Thr Phe Asp Gly Leu Lys Tyr Leu Phe 
    130                 135                 140                 


Pro Gly Glu Cys Gln Tyr Val Leu Val Gln Asp Tyr Cys Gly Ser Asn 
145                 150                 155                 160 


Pro Gly Thr Phe Arg Ile Leu Val Gly Asn Lys Gly Cys Ser His Pro 
                165                 170                 175     


Ser Val Lys Cys Lys Lys Arg Val Thr Ile Leu Val Glu Gly Gly Glu 
            180                 185                 190         


Ile Glu Leu Phe Asp Gly Glu Val Asn Val Lys Arg Pro Met Lys Asp 
        195                 200                 205             


Glu Thr His Phe Glu Val Val Glu Ser Gly Arg Tyr Ile Ile Leu Leu 
    210                 215                 220                 


Leu Gly Lys Ala Leu Ser Val Val Trp Asp Arg His Leu Ser Ile Ser 
225                 230                 235                 240 


Val Val Leu Lys Gln Thr Tyr Gln Glu Lys Val Cys Gly Leu Cys Gly 
                245                 250                 255     


Asn Phe Asp Gly Ile Gln Asn Asn Asp Leu Thr Ser Ser Asn Leu Gln 
            260                 265                 270         


Val Glu Glu Asp Pro Val Asp Phe Gly Asn Ser Trp Lys Val Ser Ser 
        275                 280                 285             


Gln Cys Ala Asp Thr Arg Lys Val Pro Leu Asp Ser Ser Pro Ala Thr 
    290                 295                 300                 


Cys His Asn Asn Ile Met Lys Gln Thr Met Val Asp Ser Ser Cys Arg 
305                 310                 315                 320 


Ile Leu Thr Ser Asp Val Phe Gln Asp Cys Asn Lys Leu Val Asp Pro 
                325                 330                 335     


Glu Pro Tyr Leu Asp Val Cys Ile Tyr Asp Thr Cys Ser Cys Glu Ser 
            340                 345                 350         


Ile Gly Asp Cys Ala Cys Phe Cys Asp Thr Ile Ala Ala Tyr Ala His 
        355                 360                 365             


Val Cys Ala Gln His Gly Lys Val Val Thr Trp Arg Thr Ala Thr Leu 
    370                 375                 380                 


Cys Pro Gln Ser Cys Glu Glu Arg Asn Leu Arg Glu Asn Gly Tyr Glu 
385                 390                 395                 400 


Cys Glu Trp Arg Tyr Asn Ser Cys Ala Pro Ala Cys Gln Val Thr Cys 
                405                 410                 415     


Gln His Pro Glu Pro Leu Ala Cys Pro Val Gln Cys Val Glu Gly Cys 
            420                 425                 430         


His Ala His Cys Pro Pro Gly Lys Ile Leu Asp Glu Leu Leu Gln Thr 
        435                 440                 445             


Cys Val Asp Pro Glu Asp Cys Pro Val Cys Glu Val Ala Gly Arg Arg 
    450                 455                 460                 


Phe Ala Ser Gly Lys Lys Val Thr Leu Asn Pro Ser Asp Pro Glu His 
465                 470                 475                 480 


Cys Gln Ile Cys His Cys Asp Val Val Asn Leu Thr Cys Glu Ala Cys 
                485                 490                 495     


Gln Glu Pro Gly Gly Leu Val Val Pro Pro Thr Asp Ala Pro Val Ser 
            500                 505                 510         


Pro Thr Thr Leu Tyr Val Glu Asp Ile Ser Glu Pro Pro Leu His Asp 
        515                 520                 525             


Phe Tyr Cys Ser Arg Leu Leu Asp Leu Val Phe Leu Leu Asp Gly Ser 
    530                 535                 540                 


Ser Arg Leu Ser Glu Ala Glu Phe Glu Val Leu Lys Ala Phe Val Val 
545                 550                 555                 560 


Asp Met Met Glu Arg Leu Arg Ile Ser Gln Lys Trp Val Arg Val Ala 
                565                 570                 575     


Val Val Glu Tyr His Asp Gly Ser His Ala Tyr Ile Gly Leu Lys Asp 
            580                 585                 590         


Arg Lys Arg Pro Ser Glu Leu Arg Arg Ile Ala Ser Gln Val Lys Tyr 
        595                 600                 605             


Ala Gly Ser Gln Val Ala Ser Thr Ser Glu Val Leu Lys Tyr Thr Leu 
    610                 615                 620                 


Phe Gln Ile Phe Ser Lys Ile Asp Arg Pro Glu Ala Ser Arg Ile Ala 
625                 630                 635                 640 


Leu Leu Leu Met Ala Ser Gln Glu Pro Gln Arg Met Ser Arg Asn Phe 
                645                 650                 655     


Val Arg Tyr Val Gln Gly Leu Lys Lys Lys Lys Val Ile Val Ile Pro 
            660                 665                 670         


Val Gly Ile Gly Pro His Ala Asn Leu Lys Gln Ile Arg Leu Ile Glu 
        675                 680                 685             


Lys Gln Ala Pro Glu Asn Lys Ala Phe Val Leu Ser Ser Val Asp Glu 
    690                 695                 700                 


Leu Glu Gln Gln Arg Asp Glu Ile Val Ser Tyr Leu Cys Asp Leu Ala 
705                 710                 715                 720 


Pro Glu Ala Pro Pro Pro Thr Leu Pro Pro His Met Ala Gln Val Thr 
                725                 730                 735     


Val Gly Pro Gly Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro 
            740                 745                 750         


Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys 
        755                 760                 765             


Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val 
    770                 775                 780                 


Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp 
785                 790                 795                 800 


Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr 
                805                 810                 815     


Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp 
            820                 825                 830         


Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu 
        835                 840                 845             


Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg 
    850                 855                 860                 


Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys 
865                 870                 875                 880 


Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp 
                885                 890                 895     


Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys 
            900                 905                 910         


Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser 
        915                 920                 925             


Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser 
    930                 935                 940                 


Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser 
945                 950                 955                 960 


Leu Ser Leu Ser Pro Gly Lys 
                965         


<210>  39
<211>  1365
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  sequence

<400>  39

Met Ile Pro Ala Arg Phe Ala Gly Val Leu Leu Ala Leu Ala Leu Ile 
1               5                   10                  15      


Leu Pro Gly Thr Leu Cys Ser Leu Ser Cys Arg Pro Pro Met Val Lys 
            20                  25                  30          


Leu Val Cys Pro Ala Asp Asn Leu Arg Ala Glu Gly Leu Glu Cys Thr 
        35                  40                  45              


Lys Thr Cys Gln Asn Tyr Asp Leu Glu Cys Met Ser Met Gly Cys Val 
    50                  55                  60                  


Ser Gly Cys Leu Cys Pro Pro Gly Met Val Arg His Glu Asn Arg Cys 
65                  70                  75                  80  


Val Ala Leu Glu Arg Cys Pro Cys Phe His Gln Gly Lys Glu Tyr Ala 
                85                  90                  95      


Pro Gly Glu Thr Val Lys Ile Gly Cys Asn Thr Cys Val Cys Arg Asp 
            100                 105                 110         


Arg Lys Trp Asn Cys Thr Asp His Val Cys Asp Ala Thr Cys Ser Thr 
        115                 120                 125             


Ile Gly Met Ala His Tyr Leu Thr Phe Asp Gly Leu Lys Tyr Leu Phe 
    130                 135                 140                 


Pro Gly Glu Cys Gln Tyr Val Leu Val Gln Asp Tyr Cys Gly Ser Asn 
145                 150                 155                 160 


Pro Gly Thr Phe Arg Ile Leu Val Gly Asn Lys Gly Cys Ser His Pro 
                165                 170                 175     


Ser Val Lys Cys Lys Lys Arg Val Thr Ile Leu Val Glu Gly Gly Glu 
            180                 185                 190         


Ile Glu Leu Phe Asp Gly Glu Val Asn Val Lys Arg Pro Met Lys Asp 
        195                 200                 205             


Glu Thr His Phe Glu Val Val Glu Ser Gly Arg Tyr Ile Ile Leu Leu 
    210                 215                 220                 


Leu Gly Lys Ala Leu Ser Val Val Trp Asp Arg His Leu Ser Ile Ser 
225                 230                 235                 240 


Val Val Leu Lys Gln Thr Tyr Gln Glu Lys Val Cys Gly Leu Cys Gly 
                245                 250                 255     


Asn Phe Asp Gly Ile Gln Asn Asn Asp Leu Thr Ser Ser Asn Leu Gln 
            260                 265                 270         


Val Glu Glu Asp Pro Val Asp Phe Gly Asn Ser Trp Lys Val Ser Ser 
        275                 280                 285             


Gln Cys Ala Asp Thr Arg Lys Val Pro Leu Asp Ser Ser Pro Ala Thr 
    290                 295                 300                 


Cys His Asn Asn Ile Met Lys Gln Thr Met Val Asp Ser Ser Cys Arg 
305                 310                 315                 320 


Ile Leu Thr Ser Asp Val Phe Gln Asp Cys Asn Lys Leu Val Asp Pro 
                325                 330                 335     


Glu Pro Tyr Leu Asp Val Cys Ile Tyr Asp Thr Cys Ser Cys Glu Ser 
            340                 345                 350         


Ile Gly Asp Cys Ala Cys Phe Cys Asp Thr Ile Ala Ala Tyr Ala His 
        355                 360                 365             


Val Cys Ala Gln His Gly Lys Val Val Thr Trp Arg Thr Ala Thr Leu 
    370                 375                 380                 


Cys Pro Gln Ser Cys Glu Glu Arg Asn Leu Arg Glu Asn Gly Tyr Glu 
385                 390                 395                 400 


Cys Glu Trp Arg Tyr Asn Ser Cys Ala Pro Ala Cys Gln Val Thr Cys 
                405                 410                 415     


Gln His Pro Glu Pro Leu Ala Cys Pro Val Gln Cys Val Glu Gly Cys 
            420                 425                 430         


His Ala His Cys Pro Pro Gly Lys Ile Leu Asp Glu Leu Leu Gln Thr 
        435                 440                 445             


Cys Val Asp Pro Glu Asp Cys Pro Val Cys Glu Val Ala Gly Arg Arg 
    450                 455                 460                 


Phe Ala Ser Gly Lys Lys Val Thr Leu Asn Pro Ser Asp Pro Glu His 
465                 470                 475                 480 


Cys Gln Ile Cys His Cys Asp Val Val Asn Leu Thr Cys Glu Ala Cys 
                485                 490                 495     


Gln Glu Pro Gly Gly Leu Val Val Pro Pro Thr Asp Ala Pro Val Ser 
            500                 505                 510         


Pro Thr Thr Leu Tyr Val Glu Asp Ile Ser Glu Pro Pro Leu His Asp 
        515                 520                 525             


Phe Tyr Cys Ser Arg Leu Leu Asp Leu Val Phe Leu Leu Asp Gly Ser 
    530                 535                 540                 


Ser Arg Leu Ser Glu Ala Glu Phe Glu Val Leu Lys Ala Phe Val Val 
545                 550                 555                 560 


Asp Met Met Glu Arg Leu Arg Ile Ser Gln Lys Trp Val Arg Val Ala 
                565                 570                 575     


Val Val Glu Tyr His Asp Gly Ser His Ala Tyr Ile Gly Leu Lys Asp 
            580                 585                 590         


Arg Lys Arg Pro Ser Glu Leu Arg Arg Ile Ala Ser Gln Val Lys Tyr 
        595                 600                 605             


Ala Gly Ser Gln Val Ala Ser Thr Ser Glu Val Leu Lys Tyr Thr Leu 
    610                 615                 620                 


Phe Gln Ile Phe Ser Lys Ile Asp Arg Pro Glu Ala Ser Arg Ile Ala 
625                 630                 635                 640 


Leu Leu Leu Met Ala Ser Gln Glu Pro Gln Arg Met Ser Arg Asn Phe 
                645                 650                 655     


Val Arg Tyr Val Gln Gly Leu Lys Lys Lys Lys Val Ile Val Ile Pro 
            660                 665                 670         


Val Gly Ile Gly Pro His Ala Asn Leu Lys Gln Ile Arg Leu Ile Glu 
        675                 680                 685             


Lys Gln Ala Pro Glu Asn Lys Ala Phe Val Leu Ser Ser Val Asp Glu 
    690                 695                 700                 


Leu Glu Gln Gln Arg Asp Glu Ile Val Ser Tyr Leu Cys Asp Leu Ala 
705                 710                 715                 720 


Pro Glu Ala Pro Pro Pro Thr Leu Pro Pro His Met Ala Gln Val Thr 
                725                 730                 735     


Val Gly Pro Gly Leu Leu Gly Val Ser Thr Leu Gly Pro Lys Arg Asn 
            740                 745                 750         


Ser Met Val Leu Asp Val Ala Phe Val Leu Glu Gly Ser Asp Lys Ile 
        755                 760                 765             


Gly Glu Ala Asp Phe Asn Arg Ser Lys Glu Phe Met Glu Glu Val Ile 
    770                 775                 780                 


Gln Arg Met Asp Val Gly Gln Asp Ser Ile His Val Thr Val Leu Gln 
785                 790                 795                 800 


Tyr Ser Tyr Met Val Thr Val Glu Tyr Pro Phe Ser Glu Ala Gln Ser 
                805                 810                 815     


Lys Gly Asp Ile Leu Gln Arg Val Arg Glu Ile Arg Tyr Gln Gly Gly 
            820                 825                 830         


Asn Arg Thr Asn Thr Gly Leu Ala Leu Arg Tyr Leu Ser Asp His Ser 
        835                 840                 845             


Phe Leu Val Ser Gln Gly Asp Arg Glu Gln Ala Pro Asn Leu Val Tyr 
    850                 855                 860                 


Met Val Thr Gly Asn Pro Ala Ser Asp Glu Ile Lys Arg Leu Pro Gly 
865                 870                 875                 880 


Asp Ile Gln Val Val Pro Ile Gly Val Gly Pro Asn Ala Asn Val Gln 
                885                 890                 895     


Glu Leu Glu Arg Ile Gly Trp Pro Asn Ala Pro Ile Leu Ile Gln Asp 
            900                 905                 910         


Phe Glu Thr Leu Pro Arg Glu Ala Pro Asp Leu Val Leu Gln Arg Cys 
        915                 920                 925             


Cys Ser Gly Glu Gly Leu Gln Ile Pro Thr Leu Ser Pro Ala Pro Asp 
    930                 935                 940                 


Cys Ser Gln Pro Leu Asp Val Ile Leu Leu Leu Asp Gly Ser Ser Ser 
945                 950                 955                 960 


Phe Pro Ala Ser Tyr Phe Asp Glu Met Lys Ser Phe Ala Lys Ala Phe 
                965                 970                 975     


Ile Ser Lys Ala Asn Ile Gly Pro Arg Leu Thr Gln Val Ser Val Leu 
            980                 985                 990         


Gln Tyr Gly Ser Ile Thr Thr Ile  Asp Val Pro Trp Asn  Val Val Pro 
        995                 1000                 1005             


Glu Lys  Ala His Leu Leu Ser  Leu Val Asp Val Met  Gln Arg Glu 
    1010                 1015                 1020             


Gly Gly  Pro Ser Gln Ile Gly  Asp Ala Leu Gly Phe  Ala Val Arg 
    1025                 1030                 1035             


Tyr Leu  Thr Ser Glu Met His  Gly Ala Arg Pro Gly  Ala Ser Lys 
    1040                 1045                 1050             


Ala Val  Val Ile Leu Val Thr  Asp Val Ser Val Asp  Ser Val Asp 
    1055                 1060                 1065             


Ala Ala  Ala Asp Ala Ala Arg  Ser Asn Arg Val Thr  Val Phe Pro 
    1070                 1075                 1080             


Ile Gly  Ile Gly Asp Arg Tyr  Asp Ala Ala Gln Leu  Arg Ile Leu 
    1085                 1090                 1095             


Ala Gly  Pro Ala Gly Asp Ser  Asn Val Val Lys Leu  Gln Arg Ile 
    1100                 1105                 1110             


Glu Asp  Leu Pro Thr Met Val  Thr Leu Gly Asn Ser  Phe Leu His 
    1115                 1120                 1125             


Lys Leu  Cys Ser Gly Phe Val  Arg Ile Cys Asp Lys  Thr His Thr 
    1130                 1135                 1140             


Cys Pro  Pro Cys Pro Ala Pro  Glu Leu Leu Gly Gly  Pro Ser Val 
    1145                 1150                 1155             


Phe Leu  Phe Pro Pro Lys Pro  Lys Asp Thr Leu Met  Ile Ser Arg 
    1160                 1165                 1170             


Thr Pro  Glu Val Thr Cys Val  Val Val Asp Val Ser  His Glu Asp 
    1175                 1180                 1185             


Pro Glu  Val Lys Phe Asn Trp  Tyr Val Asp Gly Val  Glu Val His 
    1190                 1195                 1200             


Asn Ala  Lys Thr Lys Pro Arg  Glu Glu Gln Tyr Asn  Ser Thr Tyr 
    1205                 1210                 1215             


Arg Val  Val Ser Val Leu Thr  Val Leu His Gln Asp  Trp Leu Asn 
    1220                 1225                 1230             


Gly Lys  Glu Tyr Lys Cys Lys  Val Ser Asn Lys Ala  Leu Pro Ala 
    1235                 1240                 1245             


Pro Ile  Glu Lys Thr Ile Ser  Lys Ala Lys Gly Gln  Pro Arg Glu 
    1250                 1255                 1260             


Pro Gln  Val Tyr Thr Leu Pro  Pro Ser Arg Asp Glu  Leu Thr Lys 
    1265                 1270                 1275             


Asn Gln  Val Ser Leu Thr Cys  Leu Val Lys Gly Phe  Tyr Pro Ser 
    1280                 1285                 1290             


Asp Ile  Ala Val Glu Trp Glu  Ser Asn Gly Gln Pro  Glu Asn Asn 
    1295                 1300                 1305             


Tyr Lys  Thr Thr Pro Pro Val  Leu Asp Ser Asp Gly  Ser Phe Phe 
    1310                 1315                 1320             


Leu Tyr  Ser Lys Leu Thr Val  Asp Lys Ser Arg Trp  Gln Gln Gly 
    1325                 1330                 1335             


Asn Val  Phe Ser Cys Ser Val  Met His Glu Ala Leu  His Asn His 
    1340                 1345                 1350             


Tyr Thr  Gln Lys Ser Leu Ser  Leu Ser Pro Gly Lys  
    1355                 1360                 1365 


<210>  40
<211>  22
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  sequence

<400>  40

Met Ile Pro Ala Arg Phe Ala Gly Val Leu Leu Ala Leu Ala Leu Ile 
1               5                   10                  15      


Leu Pro Gly Thr Leu Cys 
            20          


<210>  41
<211>  741
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  sequence

<400>  41

Ala Glu Gly Thr Arg Gly Arg Ser Ser Thr Ala Arg Cys Ser Leu Phe 
1               5                   10                  15      


Gly Ser Asp Phe Val Asn Thr Phe Asp Gly Ser Met Tyr Ser Phe Ala 
            20                  25                  30          


Gly Tyr Cys Ser Tyr Leu Leu Ala Gly Gly Cys Gln Lys Arg Ser Phe 
        35                  40                  45              


Ser Ile Ile Gly Asp Phe Gln Asn Gly Lys Arg Val Ser Leu Ser Val 
    50                  55                  60                  


Tyr Leu Gly Glu Phe Phe Asp Ile His Leu Phe Val Asn Gly Thr Val 
65                  70                  75                  80  


Thr Gln Gly Asp Gln Arg Val Ser Met Pro Tyr Ala Ser Lys Gly Leu 
                85                  90                  95      


Tyr Leu Glu Thr Glu Ala Gly Tyr Tyr Lys Leu Ser Gly Glu Ala Tyr 
            100                 105                 110         


Gly Phe Val Ala Arg Ile Asp Gly Ser Gly Asn Phe Gln Val Leu Leu 
        115                 120                 125             


Ser Asp Arg Tyr Phe Asn Lys Thr Cys Gly Leu Cys Gly Asn Phe Asn 
    130                 135                 140                 


Ile Phe Ala Glu Asp Asp Phe Met Thr Gln Glu Gly Thr Leu Thr Ser 
145                 150                 155                 160 


Asp Pro Tyr Asp Phe Ala Asn Ser Trp Ala Leu Ser Ser Gly Glu Gln 
                165                 170                 175     


Trp Cys Glu Arg Ala Ser Pro Pro Ser Ser Ser Cys Asn Ile Ser Ser 
            180                 185                 190         


Gly Glu Met Gln Lys Gly Leu Trp Glu Gln Cys Gln Leu Leu Lys Ser 
        195                 200                 205             


Thr Ser Val Phe Ala Arg Cys His Pro Leu Val Asp Pro Glu Pro Phe 
    210                 215                 220                 


Val Ala Leu Cys Glu Lys Thr Leu Cys Glu Cys Ala Gly Gly Leu Glu 
225                 230                 235                 240 


Cys Ala Cys Pro Ala Leu Leu Glu Tyr Ala Arg Thr Cys Ala Gln Glu 
                245                 250                 255     


Gly Met Val Leu Tyr Gly Trp Thr Asp His Ser Ala Cys Ser Pro Val 
            260                 265                 270         


Cys Pro Ala Gly Met Glu Tyr Arg Gln Cys Val Ser Pro Cys Ala Arg 
        275                 280                 285             


Thr Cys Gln Ser Leu His Ile Asn Glu Met Cys Gln Glu Arg Cys Val 
    290                 295                 300                 


Asp Gly Cys Ser Cys Pro Glu Gly Gln Leu Leu Asp Glu Gly Leu Cys 
305                 310                 315                 320 


Val Glu Ser Thr Glu Cys Pro Cys Val His Ser Gly Lys Arg Tyr Pro 
                325                 330                 335     


Pro Gly Thr Ser Leu Ser Arg Asp Cys Asn Thr Cys Ile Cys Arg Asn 
            340                 345                 350         


Ser Gln Trp Ile Cys Ser Asn Glu Glu Cys Pro Gly Glu Cys Leu Val 
        355                 360                 365             


Thr Gly Gln Ser His Phe Lys Ser Phe Asp Asn Arg Tyr Phe Thr Phe 
    370                 375                 380                 


Ser Gly Ile Cys Gln Tyr Leu Leu Ala Arg Asp Cys Gln Asp His Ser 
385                 390                 395                 400 


Phe Ser Ile Val Ile Glu Thr Val Gln Cys Ala Asp Asp Arg Asp Ala 
                405                 410                 415     


Val Cys Thr Arg Ser Val Thr Val Arg Leu Pro Gly Leu His Asn Ser 
            420                 425                 430         


Leu Val Lys Leu Lys His Gly Ala Gly Val Ala Met Asp Gly Gln Asp 
        435                 440                 445             


Ile Gln Leu Pro Leu Leu Lys Gly Asp Leu Arg Ile Gln His Thr Val 
    450                 455                 460                 


Thr Ala Ser Val Arg Leu Ser Tyr Gly Glu Asp Leu Gln Met Asp Trp 
465                 470                 475                 480 


Asp Gly Arg Gly Arg Leu Leu Val Lys Leu Ser Pro Val Tyr Ala Gly 
                485                 490                 495     


Lys Thr Cys Gly Leu Cys Gly Asn Tyr Asn Gly Asn Gln Gly Asp Asp 
            500                 505                 510         


Phe Leu Thr Pro Ser Gly Leu Ala Glu Pro Arg Val Glu Asp Phe Gly 
        515                 520                 525             


Asn Ala Trp Lys Leu His Gly Asp Cys Gln Asp Leu Gln Lys Gln His 
    530                 535                 540                 


Ser Asp Pro Cys Ala Leu Asn Pro Arg Met Thr Arg Phe Ser Glu Glu 
545                 550                 555                 560 


Ala Cys Ala Val Leu Thr Ser Pro Thr Phe Glu Ala Cys His Arg Ala 
                565                 570                 575     


Val Ser Pro Leu Pro Tyr Leu Arg Asn Cys Arg Tyr Asp Val Cys Ser 
            580                 585                 590         


Cys Ser Asp Gly Arg Glu Cys Leu Cys Gly Ala Leu Ala Ser Tyr Ala 
        595                 600                 605             


Ala Ala Cys Ala Gly Arg Gly Val Arg Val Ala Trp Arg Glu Pro Gly 
    610                 615                 620                 


Arg Cys Glu Leu Asn Cys Pro Lys Gly Gln Val Tyr Leu Gln Cys Gly 
625                 630                 635                 640 


Thr Pro Cys Asn Leu Thr Cys Arg Ser Leu Ser Tyr Pro Asp Glu Glu 
                645                 650                 655     


Cys Asn Glu Ala Cys Leu Glu Gly Cys Phe Cys Pro Pro Gly Leu Tyr 
            660                 665                 670         


Met Asp Glu Arg Gly Asp Cys Val Pro Lys Ala Gln Cys Pro Cys Tyr 
        675                 680                 685             


Tyr Asp Gly Glu Ile Phe Gln Pro Glu Asp Ile Phe Ser Asp His His 
    690                 695                 700                 


Thr Met Cys Tyr Cys Glu Asp Gly Phe Met His Cys Thr Met Ser Gly 
705                 710                 715                 720 


Val Pro Gly Ser Leu Leu Pro Asp Ala Val Leu Ser Ser Pro Leu Ser 
                725                 730                 735     


His Arg Ser Lys Arg 
            740     


<210>  42
<211>  2904
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  sequence

<400>  42
atgatccccg ccagattcgc cggcgtgctg ctggccctgg ccctgatcct gcccggcacc       60

ctgtgcagcc tgagctgcag accccccatg gtcaagctcg tgtgcccagc cgacaatctg      120

cgggccgagg ggctggaatg caccaagacc tgccagaact acgacctgga atgcatgagc      180

atgggctgcg tgagcggctg cctgtgccca cccggcatgg tccggcacga gaacagatgc      240

gtggccctgg aacggtgccc atgcttccac cagggcaaag agtacgcccc tggcgagaca      300

gtgaagatcg gctgcaatac ctgcgtgtgc cgggaccgga agtggaactg caccgaccac      360

gtgtgcgacg ccacatgcag caccatcggc atggcccact acctgacctt tgacggcctg      420

aagtacctgt tccccggcga gtgccagtac gtgctggtgc aggactactg cggcagcaac      480

cccggcacct tccggatcct cgtgggcaac aagggatgca gccaccccag cgtgaagtgc      540

aagaaacgcg tgaccatcct ggtggagggc ggcgagatcg agctgttcga cggcgaagtg      600

aacgtgaagc ggcccatgaa ggacgagaca cacttcgagg tggtggagag cggccggtac      660

atcatcctgc tgctgggcaa ggctctgagc gtcgtgtggg accggcacct gagcatcagc      720

gtggtgctga agcagaccta ccaggaaaaa gtctgcggcc tctgtggcaa tttcgacggc      780

atccagaaca acgatctgac cagcagcaac ctgcaggtgg aagaggaccc cgtggacttt      840

ggcaatagct ggaaggtgtc cagccagtgt gccgacacca gaaaagtgcc cctggactct      900

agccccgcca cctgccacaa caacatcatg aagcagacaa tggtggacag ctcctgccgg      960

atcctgacct ccgacgtgtt ccaggactgt aacaaactgg tggatcctga gccttacctg     1020

gacgtgtgca tctacgacac ctgcagctgc gagagcatcg gcgattgcgc ctgcttctgc     1080

gacacaatcg ccgcctacgc ccatgtgtgc gcccagcacg gcaaggtggt cacctggcgg     1140

accgcaaccc tgtgccccca gagctgcgag gaacggaacc tgcgggagaa cggctacgag     1200

tgcgagtggc ggtacaacag ctgcgcccca gcctgccagg tcacctgcca gcaccccgag     1260

cctctggcct gccccgtgca gtgcgtggag ggctgccacg cccactgccc tccaggcaag     1320

atcctggacg agctgctgca gacctgcgtg gaccctgagg actgccctgt gtgcgaggtg     1380

gccggcaggc ggttcgcctc cggcaagaaa gtgaccctga accctagcga ccccgagcac     1440

tgccagatct gccactgcga cgtggtcaat ctgacctgcg aggcttgcca ggaaccaggc     1500

ggcctcgtcg tgccccctac cgacgcccct gtgtccccaa ccaccctgta cgtggaggac     1560

atcagcgagc cccccctgca cgacttctac tgctctcggc tgctggacct ggtgttcctg     1620

ctggacggca gttctagact gagcgaggcc gagttcgagg tgctgaaggc cttcgtcgtg     1680

gacatgatgg aacggctgcg gatcagccag aaatgggtcc gggtggccgt ggtggagtac     1740

cacgacggca gccacgccta catcggcctg aaggaccgga agcggccctc cgaactccgg     1800

cggatcgcca gccaggtcaa gtacgccgga tcccaggtgg ccagcaccag cgaagtgctg     1860

aagtacaccc tgttccagat cttcagcaag atcgaccggc ccgaggccag ccggatcgca     1920

ctgctgctga tggccagcca agaaccccag cggatgagcc ggaacttcgt gagatacgtg     1980

cagggcctga agaaaaagaa agtgatcgtg atccccgtgg gcatcggccc ccacgccaac     2040

ctgaagcaga tccggctgat cgagaagcag gcacccgaga acaaggcctt tgtgctgtcc     2100

agcgtggatg agctggaaca gcagcgggac gagatcgtgt cctacctgtg cgacctggcc     2160

cctgaggccc ctcctcccac actgcccccc cacatggctc aggtcaccgt gggaccaggc     2220

gacaaaactc acacatgccc accgtgccca gcacctgaac tcctgggggg accgtcagtc     2280

ttcctcttcc ccccaaaacc caaggacacc ctcatgatct cccggacccc tgaggtcaca     2340

tgcgtggtgg tggacgtgag ccacgaagac cctgaggtca agttcaactg gtacgtggac     2400

ggcgtggagg tgcataatgc caagacaaag ccgcgggagg agcagtacaa cagcacgtac     2460

cgtgtggtca gcgtcctcac cgtcctgcac caggactggc tgaatggcaa ggagtacaag     2520

tgcaaggtct ccaacaaagc cctcccagcc cccatcgaga aaaccatctc caaagccaaa     2580

gggcagcccc gagagccaca ggtgtacacc ctgcccccat cccgggatga gctgaccaag     2640

aaccaggtca gcctgacctg cctggtcaaa ggcttctatc ccagcgacat cgccgtggag     2700

tgggagagca atgggcagcc ggagaacaac tacaagacca cgcctcccgt gctggactcc     2760

gacggctcct tcttcctcta cagcaagctc accgtggaca agagcaggtg gcagcagggg     2820

aacgtcttct catgctccgt gatgcatgag gctctgcaca accactacac gcagaagagc     2880

ctctccctgt ctccgggtaa atga                                            2904


<210>  43
<211>  4098
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  sequence

<400>  43
atgatccccg ccagattcgc cggcgtgctg ctggccctgg ccctgatcct gcccggcacc       60

ctgtgcagcc tgagctgcag accccccatg gtcaagctcg tgtgcccagc cgacaatctg      120

cgggccgagg ggctggaatg caccaagacc tgccagaact acgacctgga atgcatgagc      180

atgggctgcg tgagcggctg cctgtgccca cccggcatgg tccggcacga gaacagatgc      240

gtggccctgg aacggtgccc atgcttccac cagggcaaag agtacgcccc tggcgagaca      300

gtgaagatcg gctgcaatac ctgcgtgtgc cgggaccgga agtggaactg caccgaccac      360

gtgtgcgacg ccacatgcag caccatcggc atggcccact acctgacctt tgacggcctg      420

aagtacctgt tccccggcga gtgccagtac gtgctggtgc aggactactg cggcagcaac      480

cccggcacct tccggatcct cgtgggcaac aagggatgca gccaccccag cgtgaagtgc      540

aagaaacgcg tgaccatcct ggtggagggc ggcgagatcg agctgttcga cggcgaagtg      600

aacgtgaagc ggcccatgaa ggacgagaca cacttcgagg tggtggagag cggccggtac      660

atcatcctgc tgctgggcaa ggctctgagc gtcgtgtggg accggcacct gagcatcagc      720

gtggtgctga agcagaccta ccaggaaaaa gtctgcggcc tctgtggcaa tttcgacggc      780

atccagaaca acgatctgac cagcagcaac ctgcaggtgg aagaggaccc cgtggacttt      840

ggcaatagct ggaaggtgtc cagccagtgt gccgacacca gaaaagtgcc cctggactct      900

agccccgcca cctgccacaa caacatcatg aagcagacaa tggtggacag ctcctgccgg      960

atcctgacct ccgacgtgtt ccaggactgt aacaaactgg tggatcctga gccttacctg     1020

gacgtgtgca tctacgacac ctgcagctgc gagagcatcg gcgattgcgc ctgcttctgc     1080

gacacaatcg ccgcctacgc ccatgtgtgc gcccagcacg gcaaggtggt cacctggcgg     1140

accgcaaccc tgtgccccca gagctgcgag gaacggaacc tgcgggagaa cggctacgag     1200

tgcgagtggc ggtacaacag ctgcgcccca gcctgccagg tcacctgcca gcaccccgag     1260

cctctggcct gccccgtgca gtgcgtggag ggctgccacg cccactgccc tccaggcaag     1320

atcctggacg agctgctgca gacctgcgtg gaccctgagg actgccctgt gtgcgaggtg     1380

gccggcaggc ggttcgcctc cggcaagaaa gtgaccctga accctagcga ccccgagcac     1440

tgccagatct gccactgcga cgtggtcaat ctgacctgcg aggcttgcca ggaaccaggc     1500

ggcctcgtcg tgccccctac cgacgcccct gtgtccccaa ccaccctgta cgtggaggac     1560

atcagcgagc cccccctgca cgacttctac tgctctcggc tgctggacct ggtgttcctg     1620

ctggacggca gttctagact gagcgaggcc gagttcgagg tgctgaaggc cttcgtcgtg     1680

gacatgatgg aacggctgcg gatcagccag aaatgggtcc gggtggccgt ggtggagtac     1740

cacgacggca gccacgccta catcggcctg aaggaccgga agcggccctc cgaactccgg     1800

cggatcgcca gccaggtcaa gtacgccgga tcccaggtgg ccagcaccag cgaagtgctg     1860

aagtacaccc tgttccagat cttcagcaag atcgaccggc ccgaggccag ccggatcgca     1920

ctgctgctga tggccagcca agaaccccag cggatgagcc ggaacttcgt gagatacgtg     1980

cagggcctga agaaaaagaa agtgatcgtg atccccgtgg gcatcggccc ccacgccaac     2040

ctgaagcaga tccggctgat cgagaagcag gcacccgaga acaaggcctt tgtgctgtcc     2100

agcgtggatg agctggaaca gcagcgggac gagatcgtgt cctacctgtg cgacctggcc     2160

cctgaggccc ctcctcccac actgcccccc cacatggctc aggtcaccgt gggaccaggc     2220

ctgctgggag tgagcacact gggccccaag cggaacagca tggtgctgga cgtggccttc     2280

gtgctcgagg gcagcgacaa gatcggcgag gccgacttca accggtccaa agaattcatg     2340

gaagaggtca tccagcggat ggacgtgggc caggacagca tccacgtgac agtgctgcag     2400

tacagctaca tggtcacagt ggagtacccc ttcagcgagg cccagagcaa gggcgacatc     2460

ctgcagagag tgcgggagat cagataccag ggcggcaacc ggaccaacac cggcctggcc     2520

ctgcgctacc tgagcgacca ctcctttctg gtgtctcagg gcgatcggga gcaggcccct     2580

aacctggtgt atatggtcac aggcaacccc gctagcgacg agatcaagag actgcccggc     2640

gacatccagg tggtgcccat cggcgtgggc cccaacgcta atgtgcagga actggaacgg     2700

atcggctggc ccaacgcccc catcctgatc caggacttcg agacactgcc cagagaagcc     2760

cccgacctgg tgctgcagcg gtgctgtagc ggcgaggggc tgcagatccc caccctgagc     2820

cctgcccccg actgcagcca gcccctggac gtgatcctgc tcctggacgg ctccagctcc     2880

ttccccgcca gctacttcga cgagatgaag tccttcgcca aggccttcat cagcaaggcc     2940

aacatcggcc ccagactgac ccaggtgtcc gtgctccagt acggcagcat caccaccatc     3000

gacgtgccct ggaatgtggt ccccgagaag gcccacctgc tgtccctggt ggatgtgatg     3060

cagcgggagg gcggacccag ccagatcggc gacgccctgg gcttcgccgt gagatacctg     3120

acaagcgaga tgcacggagc cagacctgga gcctccaagg ccgtggtcat cctcgtgacc     3180

gacgtgtccg tggacagcgt ggacgctgcc gccgacgccg ccagatccaa cagagtgacc     3240

gtgttcccta tcggcatcgg cgaccgctac gacgccgccc agctgagaat cctggccgga     3300

cctgccggcg acagcaacgt ggtcaaactg cagcggatcg aggatctgcc caccatggtc     3360

accctgggca acagctttct gcacaagctg tgtagcggct tcgtgcggat ctgcgacaaa     3420

actcacacat gcccaccgtg cccagcacct gaactcctgg ggggaccgtc agtcttcctc     3480

ttccccccaa aacccaagga caccctcatg atctcccgga cccctgaggt cacatgcgtg     3540

gtggtggacg tgagccacga agaccctgag gtcaagttca actggtacgt ggacggcgtg     3600

gaggtgcata atgccaagac aaagccgcgg gaggagcagt acaacagcac gtaccgtgtg     3660

gtcagcgtcc tcaccgtcct gcaccaggac tggctgaatg gcaaggagta caagtgcaag     3720

gtctccaaca aagccctccc agcccccatc gagaaaacca tctccaaagc caaagggcag     3780

ccccgagagc cacaggtgta caccctgccc ccatcccggg atgagctgac caagaaccag     3840

gtcagcctga cctgcctggt caaaggcttc tatcccagcg acatcgccgt ggagtgggag     3900

agcaatgggc agccggagaa caactacaag accacgcctc ccgtgctgga ctccgacggc     3960

tccttcttcc tctacagcaa gctcaccgtg gacaagagca ggtggcagca ggggaacgtc     4020

ttctcatgct ccgtgatgca tgaggctctg cacaaccact acacgcagaa gagcctctcc     4080

ctgtctccgg gtaaatga                                                   4098


