                         SEQUENCE LISTING

<110>  THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE 
       SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES
       UNIVERSITY HEALTH NETWORK
 
<120>  MODULATED PROGRAMMED DEATH LIGAND-1

<130>  707002

<150>  US 61/261,081
<151>  2009-11-13

<160>  47    

<170>  PatentIn version 3.5

<210>  1
<211>  290
<212>  PRT
<213>  Homo Sapiens

<400>  1

Met Arg Ile Phe Ala Val Phe Ile Phe Met Thr Tyr Trp His Leu Leu 
1               5                   10                  15      


Asn Ala Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr 
            20                  25                  30          


Gly Ser Asn Met Thr Ile Glu Cys Lys Phe Pro Val Glu Lys Gln Leu 
        35                  40                  45              


Asp Leu Ala Ala Leu Ile Val Tyr Trp Glu Met Glu Asp Lys Asn Ile 
    50                  55                  60                  


Ile Gln Phe Val His Gly Glu Glu Asp Leu Lys Val Gln His Ser Ser 
65                  70                  75                  80  


Tyr Arg Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Asn 
                85                  90                  95      


Ala Ala Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr 
            100                 105                 110         


Arg Cys Met Ile Ser Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val 
        115                 120                 125             


Lys Val Asn Ala Pro Tyr Asn Lys Ile Asn Gln Arg Ile Leu Val Val 
    130                 135                 140                 


Asp Pro Val Thr Ser Glu His Glu Leu Thr Cys Gln Ala Glu Gly Tyr 
145                 150                 155                 160 


Pro Lys Ala Glu Val Ile Trp Thr Ser Ser Asp His Gln Val Leu Ser 
                165                 170                 175     


Gly Lys Thr Thr Thr Thr Asn Ser Lys Arg Glu Glu Lys Leu Phe Asn 
            180                 185                 190         


Val Thr Ser Thr Leu Arg Ile Asn Thr Thr Thr Asn Glu Ile Phe Tyr 
        195                 200                 205             


Cys Thr Phe Arg Arg Leu Asp Pro Glu Glu Asn His Thr Ala Glu Leu 
    210                 215                 220                 


Val Ile Pro Glu Leu Pro Leu Ala His Pro Pro Asn Glu Arg Thr His 
225                 230                 235                 240 


Leu Val Ile Leu Gly Ala Ile Leu Leu Cys Leu Gly Val Ala Leu Thr 
                245                 250                 255     


Phe Ile Phe Arg Leu Arg Lys Gly Arg Met Met Asp Val Lys Lys Cys 
            260                 265                 270         


Gly Ile Gln Asp Thr Asn Ser Lys Lys Gln Ser Asp Thr His Leu Glu 
        275                 280                 285             


Glu Thr 
    290 


<210>  2
<211>  873
<212>  DNA
<213>  Homo sapiens

<400>  2
atgaggatat ttgctgtctt tatattcatg acctactggc atttgctgaa cgcatttact       60

gtcacggttc ccaaggacct atatgtggta gagtatggta gcaatatgac aattgaatgc      120

aaattcccag tagaaaaaca attagacctg gctgcactaa ttgtctattg ggaaatggag      180

gataagaaca ttattcaatt tgtgcatgga gaggaagacc tgaaggttca gcatagtagc      240

tacagacaga gggcccggct gttgaaggac cagctctccc tgggaaatgc tgcacttcag      300

atcacagatg tgaaattgca ggatgcaggg gtgtaccgct gcatgatcag ctatggtggt      360

gccgactaca agcgaattac tgtgaaagtc aatgccccat acaacaaaat caaccaaaga      420

attttggttg tggatccagt cacctctgaa catgaactga catgtcaggc tgagggctac      480

cccaaggccg aagtcatctg gacaagcagt gaccatcaag tcctgagtgg taagaccacc      540

accaccaatt ccaagagaga ggagaagctt ttcaatgtga ccagcacact gagaatcaac      600

acaacaacta atgagatttt ctactgcact tttaggagat tagatcctga ggaaaaccat      660

acagctgaat tggtcatccc agaactacct ctggcacatc ctccaaatga aaggactcac      720

ttggtaattc tgggagccat cttattatgc cttggtgtag cactgacatt catcttccgt      780

ttaagaaaag ggagaatgat ggatgtgaaa aaatgtggca tccaagatac aaactcaaag      840

aagcaaagtg atacacattt ggaggagacg taa                                   873


<210>  3
<211>  873
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide

<400>  3
atgcggatct tcgccgtgtt cattttcatg acctactggc acctgctgaa cgccttcacc       60

gtgaccgtgc ccaaagatct gtacgtggtg gagtacggca gcaacatgac aatcgaatgt      120

aaatttcccg tggagaagca gctggacctg gccgccctga tcgtgtactg ggagatggag      180

gataagaata tcatccagtt cgtgcacggc gaggaggacc tgaaagtgca gcactctagc      240

tacaggcagc gggcaagact gctcaaggac cagctgagcc tggggaacgc cgccctccag      300

atcaccgacg tgaaactcca ggacgcaggg gtgtatcggt gcatgattag ctacggcggc      360

gccgactata aacgcatcac agtgaaggtg aacgccccct acaataagat caaccagaga      420

atcctggtgg tggaccccgt gacctctgag cacgaactga catgccaggc cgagggctat      480

ccaaaagccg aagtgatctg gaccagcagc gaccaccagg tgctgtctgg gaagacaaca      540

accaccaatt ccaagcggga ggagaagctg ttcaacgtga caagcacact gcggatcaat      600

acaaccacca acgagatctt ctactgtaca tttcggcgcc tcgatcccga ggagaaccac      660

accgccgagc tggtcatccc tgaactgccc ctggctcacc caccaaacga gcggacccac      720

ctcgtgatcc tgggcgccat cctgctgtgc ctgggcgtgg ccctgacctt tatctttcgg      780

ctgagaaagg gccggatgat ggacgtgaag aaatgcggca tccaggacac caacagcaag      840

aagcagagcg atacccacct ggaagaaacc tga                                   873


<210>  4
<211>  529
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  4

Met Pro Pro Pro Arg Leu Leu Phe Phe Leu Leu Phe Leu Thr Pro Met 
1               5                   10                  15      


Glu Val Arg Pro Glu Glu Pro Leu Val Val Lys Val Glu Glu Gly Asp 
            20                  25                  30          


Asn Ala Val Leu Gln Cys Leu Lys Gly Thr Ser Asp Gly Pro Thr Gln 
        35                  40                  45              


Gln Leu Thr Trp Ser Arg Glu Ser Pro Leu Lys Pro Phe Leu Lys Leu 
    50                  55                  60                  


Ser Leu Gly Leu Pro Gly Leu Gly Ile His Met Arg Pro Leu Ala Ser 
65                  70                  75                  80  


Trp Leu Phe Ile Phe Asn Val Ser Gln Gln Met Gly Gly Phe Tyr Leu 
                85                  90                  95      


Cys Gln Pro Gly Pro Pro Ser Glu Lys Ala Trp Gln Pro Gly Trp Thr 
            100                 105                 110         


Val Asn Val Glu Gly Ser Gly Glu Leu Phe Arg Trp Asn Val Ser Asp 
        115                 120                 125             


Leu Gly Gly Leu Gly Cys Gly Leu Lys Asn Arg Ser Ser Glu Gly Pro 
    130                 135                 140                 


Ser Ser Pro Ser Gly Lys Leu Met Ser Pro Lys Leu Tyr Val Trp Ala 
145                 150                 155                 160 


Lys Asp Arg Pro Glu Ile Trp Glu Gly Glu Pro Pro Cys Val Pro Pro 
                165                 170                 175     


Arg Asp Ser Leu Asn Gln Ser Leu Ser Gln Asp Leu Thr Met Ala Pro 
            180                 185                 190         


Gly Ser Thr Leu Trp Leu Ser Cys Gly Val Pro Pro Asp Ser Val Ser 
        195                 200                 205             


Arg Gly Pro Leu Ser Trp Thr His Val His Pro Lys Gly Pro Lys Ser 
    210                 215                 220                 


Leu Leu Ser Leu Glu Leu Lys Asp Asp Arg Pro Ala Arg Asp Met Trp 
225                 230                 235                 240 


Val Met Gly Leu Leu Leu Pro Arg Ala Thr Ala Gln Asp Ala Gly Lys 
                245                 250                 255     


Tyr Tyr Cys His Arg Gly Asn Leu Thr Met Ser Phe His Leu Glu Ile 
            260                 265                 270         


Thr Ala Arg Pro Val Leu Trp His Trp Leu Leu Arg Thr Gly Gly Trp 
        275                 280                 285             


Lys Val Ser Ala Val Thr Leu Ala Tyr Leu Ile Phe Cys Leu Cys Ser 
    290                 295                 300                 


Leu Val Gly Ile Leu His Leu Ala Gly Gly Ala Ala Gly Met Ala Ala 
305                 310                 315                 320 


Arg Arg Gly Ala Leu Ile Val Leu Glu Gly Val Asp Arg Ala Gly Lys 
                325                 330                 335     


Ser Thr Gln Ser Arg Lys Leu Val Glu Ala Leu Cys Ala Ala Gly His 
            340                 345                 350         


Arg Ala Glu Leu Leu Arg Phe Pro Glu Arg Ser Thr Glu Ile Gly Lys 
        355                 360                 365             


Leu Leu Ser Ser Tyr Leu Gln Lys Lys Ser Asp Val Glu Asp His Ser 
    370                 375                 380                 


Val His Leu Leu Phe Ser Ala Asn Arg Trp Glu Gln Val Pro Leu Ile 
385                 390                 395                 400 


Lys Glu Lys Leu Ser Gln Gly Val Thr Leu Val Val Asp Arg Tyr Ala 
                405                 410                 415     


Phe Ser Gly Val Ala Tyr Thr Gly Ala Lys Glu Asn Phe Ser Leu Asp 
            420                 425                 430         


Trp Cys Lys Gln Pro Asp Val Gly Leu Pro Lys Pro Asp Leu Val Leu 
        435                 440                 445             


Phe Leu Gln Leu Gln Leu Ala Asp Ala Ala Lys Arg Gly Ala Phe Gly 
    450                 455                 460                 


His Glu Arg Tyr Glu Asn Gly Ala Phe Gln Glu Arg Ala Leu Arg Cys 
465                 470                 475                 480 


Phe His Gln Leu Met Lys Asp Thr Thr Leu Asn Trp Lys Met Val Asp 
                485                 490                 495     


Ala Ser Lys Ser Ile Glu Ala Val His Glu Asp Ile Arg Val Leu Ser 
            500                 505                 510         


Glu Asp Ala Ile Ala Thr Ala Thr Glu Lys Pro Leu Gly Glu Leu Trp 
        515                 520                 525             


Lys 
    


<210>  5
<211>  1596
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polunucleotide

<400>  5
atgccacctc ctcgcctcct cttcttcctc ctcttcctca cccccatgga agtcaggccc       60

gaggaacctc tagtggtgaa ggtggaagag ggagataacg ctgtgctgca gtgcctcaag      120

gggacctcag atggccccac tcagcagctg acctggtctc gggagtcccc gcttaaaccc      180

ttcttaaaac tcagcctggg gctgccaggc ctgggaatcc acatgaggcc cctggcatcc      240

tggcttttca tcttcaacgt ctctcaacag atggggggct tctacctgtg ccagccgggg      300

cccccctctg agaaggcctg gcagcctggc tggacagtca atgtggaggg cagcggggag      360

ctgttccggt ggaatgtttc ggacctaggt ggcctgggct gtggcctgaa gaacaggtcc      420

tcagagggcc ccagctcccc ttccgggaag ctcatgagcc ccaagctgta tgtgtgggcc      480

aaagaccgcc ctgagatctg ggagggagag cctccgtgtg tcccaccgag ggacagcctg      540

aaccagagcc tcagccagga cctcaccatg gcccctggct ccacactctg gctgtcctgt      600

ggggtacccc ctgactctgt gtccaggggc cccctctcct ggacccatgt gcaccccaag      660

gggcctaagt cattgctgag cctagagctg aaggacgatc gcccggccag agatatgtgg      720

gtaatggaga cgggtctgtt gttgccccgg gccacagctc aagacgctgg aaagtattat      780

tgtcaccgtg gcaacctgac catgtcattc cacctggaga tcactgctcg gccagtacta      840

tggcactggc tgctgaggac tggtggctgg aaggtctcag ctgtgacttt ggcttatctg      900

atcttctgcc tgtgttccct tgtgggcatt cttcatcttg ccggcggggc tgcagggatg      960

gcggcccggc gcggggctct catagtgctg gagggcgtgg accgcgccgg gaagagcacg     1020

cagagccgca agctggtgga agcgctgtgc gccgcgggcc accgcgccga actgctccgg     1080

ttcccggaaa gatcaactga aatcggcaaa cttctgagtt cctacttgca aaagaaaagt     1140

gacgtggagg atcactcggt gcacctgctt ttttctgcaa atcgctggga acaagtgccg     1200

ttaattaagg aaaagttgag ccagggcgtg accctcgtcg tggacagata cgcattttct     1260

ggtgtggcct acacaggtgc caaggagaat ttttccctag actggtgtaa acagccagac     1320

gtgggccttc ccaaacccga cctggtcctg ttcctccagt tacagctggc ggatgctgcc     1380

aagcggggag cgtttggcca tgagcgctat gagaacgggg ctttccagga gcgggcgctc     1440

cggtgtttcc accagctcat gaaagacacg actttgaact ggaagatggt ggatgcttcc     1500

aaaagcatcg aagctgtcca tgaggacatc cgcgtgctct ctgaggacgc catcgccact     1560

gccacagaga agccgctggg ggagctatgg aagtga                               1596


<210>  6
<211>  3056
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide

<400>  6
atgccacctc ctcgcctcct cttcttcctc ctcttcctca cccccatgga agtcaggccc       60

gaggaacctc tagtggtgaa ggtggaagag ggagataacg ctgtgctgca gtgcctcaag      120

gggacctcag atggccccac tcagcagctg acctggtctc gggagtcccc gcttaaaccc      180

ttcttaaaac tcagcctggg gctgccaggc ctgggaatcc acatgaggcc cctggcatcc      240

tggcttttca tcttcaacgt ctctcaacag atggggggct tctacctgtg ccagccgggg      300

cccccctctg agaaggcctg gcagcctggc tggacagtca atgtggaggg cagcggggag      360

ctgttccggt ggaatgtttc ggacctaggt ggcctgggct gtggcctgaa gaacaggtcc      420

tcagagggcc ccagctcccc ttccgggaag ctcatgagcc ccaagctgta tgtgtgggcc      480

aaagaccgcc ctgagatctg ggagggagag cctccgtgtg tcccaccgag ggacagcctg      540

aaccagagcc tcagccagga cctcaccatg gcccctggct ccacactctg gctgtcctgt      600

ggggtacccc ctgactctgt gtccaggggc cccctctcct ggacccatgt gcaccccaag      660

gggcctaagt cattgctgag cctagagctg aaggacgatc gcccggccag agatatgtgg      720

gtaatggaga cgggtctgtt gttgccccgg gccacagctc aagacgctgg aaagtattat      780

tgtcaccgtg gcaacctgac catgtcattc cacctggaga tcactgctcg gccagtacta      840

tggcactggc tgctgaggac tggtggctgg aaggtctcag ctgtgacttt ggcttatctg      900

atcttctgcc tgtgttccct tgtgggcatt cttcatcttg ccggcggggc tgcagggatg      960

gcggcccggc gcggggctct catagtgctg gagggcgtgg accgcgccgg gaagagcacg     1020

cagagccgca agctggtgga agcgctgtgc gccgcgggcc accgcgccga actgctccgg     1080

ttcccggaaa gatcaactga aatcggcaaa cttctgagtt cctacttgca aaagaaaagt     1140

gacgtggagg atcactcggt gcacctgctt ttttctgcaa atcgctggga acaagtgccg     1200

ttaattaagg aaaagttgag ccagggcgtg accctcgtcg tggacagata cgcattttct     1260

ggtgtggcct acacaggtgc caaggagaat ttttccctag actggtgtaa acagccagac     1320

gtgggccttc ccaaacccga cctggtcctg ttcctccagt tacagctggc ggatgctgcc     1380

aagcggggag cgtttggcca tgagcgctat gagaacgggg ctttccagga gcgggcgctc     1440

cggtgtttcc accagctcat gaaagacacg actttgaact ggaagatggt ggatgcttcc     1500

aaaagcatcg aagctgtcca tgaggacatc cgcgtgctct ctgaggacgc catcgccact     1560

gccacagaga agccgctggg ggagctatgg aagtgaggat ctcgattccc cctctccctc     1620

ccccccccct aacgttactg gccgaagccg cttggaataa ggccggtgtg cgtttgtcta     1680

tatgttattt tccaccatat tgccgtcttt tggcaatgtg agggcccgga aacctggccc     1740

tgtcttcttg acgagcattc ctaggggtct ttcccctctc gccaaaggaa tgcaaggtct     1800

gttgaatgtc gtgaaggaag cagttcctct ggaagcttct tgaagacaaa caacgtctgt     1860

agcgaccctt tgcaggcagc ggaacccccc acctggcgac aggtgcctct gcggccaaaa     1920

gccacgtgta taagatacac ctgcaaaggc ggcacaaccc cagtgccacg ttgtgagttg     1980

gatagttgtg gaaagagtca aatggctctc ctcaagcgta ttcaacaagg ggctgaagga     2040

tgcccagaag gtaccccatt gtatgggatc tgatctgggg cctcggtgca catgctttac     2100

atgtgtttag tcgaggttaa aaaaacgtct aggccccccg aaccacgggg acgtggtttt     2160

cctttgaaaa acacgattct agaatgcgga tcttcgccgt gttcattttc atgacctact     2220

ggcacctgct gaacgccttc accgtgaccg tgcccaaaga tctgtacgtg gtggagtacg     2280

gcagcaacat gacaatcgaa tgtaaatttc ccgtggagaa gcagctggac ctggccgccc     2340

tgatcgtgta ctgggagatg gaggataaga atatcatcca gttcgtgcac ggcgaggagg     2400

acctgaaagt gcagcactct agctacaggc agcgggcaag actgctcaag gaccagctga     2460

gcctggggaa cgccgccctc cagatcaccg acgtgaaact ccaggacgca ggggtgtatc     2520

ggtgcatgat tagctacggc ggcgccgact ataaacgcat cacagtgaag gtgaacgccc     2580

cctacaataa gatcaaccag agaatcctgg tggtggaccc cgtgacctct gagcacgaac     2640

tgacatgcca ggccgagggc tatccaaaag ccgaagtgat ctggaccagc agcgaccacc     2700

aggtgctgtc tgggaagaca acaaccacca attccaagcg ggaggagaag ctgttcaacg     2760

tgacaagcac actgcggatc aatacaacca ccaacgagat cttctactgt acatttcggc     2820

gcctcgatcc cgaggagaac cacaccgccg agctggtcat ccctgaactg cccctggctc     2880

acccaccaaa cgagcggacc cacctcgtga tcctgggcgc catcctgctg tgcctgggcg     2940

tggccctgac ctttatcttt cggctgagaa agggccggat gatggacgtg aagaaatgcg     3000

gcatccagga caccaacagc aagaagcaga gcgataccca cctggaagaa acctga         3056


<210>  7
<211>  10520
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide

<400>  7
gggcgaattg ggcccgacgt cgcatgcttg gaagggctaa ttcactccca aagaagacaa       60

gatatccttg atctgtggat ctaccacaca caaggctact tccctgatta gcagaactac      120

acaccagggc caggggtcag atatccactg acctttggat ggtgctacaa gctagtacca      180

gttgagccag ataaggtaga agaggccaat aaaggagaga acaccagctt gttacaccct      240

gtgagcctgc atgggatgga tgacccggag agagaagtgt tagagtggag gtttgacagc      300

cgcctagcat ttcatcacgt ggcccgagag ctgcatccgg agtacttcaa gaactgctga      360

tatcgagctt gctacaaggg actttccgct ggggactttc cagggaggcg tggcctgggc      420

gggactgggg agtggcgagc cctcagatcc tgcatataag cagctgcttt ttgcctgtac      480

tgggtctctc tggttagacc agatctgagc ctgggagctc tctggctaac tagggaaccc      540

actgcttaag cctcaataaa gcttgccttg agtgcttcaa gtagtgtgtg cccgtctgtt      600

gtgtgactct ggtaactaga gatccctcag acccttttag tcagtgtgga aaatctctag      660

cagtggcgcc cgaacaggga cttgaaagcg aaagggaaac cagaggagct ctctcgacgc      720

aggactcggc ttgctgaagc gcgcacggca agaggcgagg ggcggcgact ggtgagtacg      780

ccaaaaattt tgactagcgg aggctagaag gagagagatg ggtgcgagag cgtcagtatt      840

aagcggggga gaattagatc gcgatgggaa aaaattcggt taaggccagg gggaaagaaa      900

aaatataaat taaaacatat agtatgggca agcagggagc tagaacgatt cgcagttaat      960

cctggcctgt tagaaacatc agaaggctgt agacaaatac tgggacagct acaaccatcc     1020

cttcagacag gatcagaaga acttagatca ttatataata cagtagcaac cctctattgt     1080

gtgcatcaaa ggatagagat aaaagacacc aaggaagctt tagacaagat agaggaagag     1140

caaaacaaaa gtaagaccac cgcacagcaa gcggccgctg atcttcagac ctggaggagg     1200

agatatgagg gacaattgga gaagtgaatt atataaatat aaagtagtaa aaattgaacc     1260

attaggagta gcacccacca aggcaaagag aagagtggtg cagagagaaa aaagagcagt     1320

gggaatagga gctttgttcc ttgggttctt gggagcagca ggaagcacta tgggcgcagc     1380

gtcaatgacg ctgacggtac aggccagaca attattgtct ggtatagtgc agcagcagaa     1440

caatttgctg agggctattg aggcgcaaca gcatctgttg caactcacag tctggggcat     1500

caagcagctc caggcaagaa tcctggctgt ggaaagatac ctaaaggatc aacagctcct     1560

ggggatttgg ggttgctctg gaaaactcat ttgcaccact gctgtgcctt ggaatgctag     1620

ttggagtaat aaatctctgg aacagatttg gaatcacacg acctggatgg agtgggacag     1680

agaaattaac aattacacaa gcttaataca ctccttaatt gaagaatcgc aaaaccagca     1740

agaaaagaat gaacaagaat tattggaatt agataaatgg gcaagtttgt ggaattggtt     1800

taacataaca aattggctgt ggtatataaa attattcata atgatagtag gaggcttggt     1860

aggtttaaga atagtttttg ctgtactttc tatagtgaat agagttaggc agggatattc     1920

accattatcg tttcagaccc acctcccaac cccgagggga cccgacaggc ccgaaggaat     1980

agaagaagaa ggtggagaga gagacagaga cagatccatt cgattagtga acggatctcg     2040

acgggatcga ttttaaaaga aaagggggga ttggggggta cagtgcaggg gaaagaatag     2100

tagacataat agcaacagac atacaaacta aagaattaca aaaacaaatt acaaaaattc     2160

aaaattttat cgataagctt tgcaaagatg gataaagttt taaacagaga ggaatctttg     2220

cagctaatgg accttctagg tcttgaaagg agtgggaatt ggctccggtg cccgtcagtg     2280

ggcagagcgc acatcgccca cagtccccga gaagttgggg ggaggggtcg gcaattgaac     2340

cggtgcctag agaaggtggc gcggggtaaa ctgggaaagt gatgtcgtgt actggctccg     2400

cctttttccc gagggtgggg gagaaccgta tataagtgca gtagtcgccg tgaacgttct     2460

ttttcgcaac gggtttgccg ccagaacaca ggtaagtgcc gtgtgtggtt cccgcgggcc     2520

tggcctcttt acgggttatg gcccttgcgt gccttgaatt acttccacct ggctgcagta     2580

cgtgattctt gatcccgagc ttcgggttgg aagtgggtgg gagagttcga ggccttgcgc     2640

ttaaggagcc ccttcgcctc gtgcttgagt tgaggcctgg cctgggcgct ggggccgccg     2700

cgtgcgaatc tggtggcacc ttcgcgcctg tctcgctgct ttcgataagt ctctagccat     2760

ttaaaatttt tgatgacctg ctgcgacgct ttttttctgg caagatagtc ttgtaaatgc     2820

gggccaagat ctgcacactg gtatttcggt ttttggggcc gcgggcggcg acggggcccg     2880

tgcgtcccag cgcacatgtt cggcgaggcg gggcctgcga gcgcggccac cgagaatcgg     2940

acgggggtag tctcaagctg gccggcctgc tctggtgcct ggcctcgcgc cgccgtgtat     3000

cgccccgccc tgggcggcaa ggctggcccg gtcggcacca gttgcgtgag cggaaagatg     3060

gccgcttccc ggccctgctg cagggagctc aaaatggagg acgcggcgct cgggagagcg     3120

ggcgggtgag tcacccacac aaaggaaaag ggcctttccg tcctcagccg tcgcttcatg     3180

tgactccacg gagtaccggg cgccgtccag gcacctcgat tagttctcga gcttttggag     3240

tacgtcgtct ttaggttggg gggaggggtt ttatgcgatg gagtttcccc acactgagtg     3300

ggtggagact gaagttaggc cagcttggca cttgatgtaa ttctccttgg aatttgccct     3360

ttttgagttt ggatcttggt tcattctcaa gcctcagaca gtggttcaaa gtttttttct     3420

tccatttcag gtgtcgtgag gaattcatgc cacctcctcg cctcctcttc ttcctcctct     3480

tcctcacccc catggaagtc aggcccgagg aacctctagt ggtgaaggtg gaagagggag     3540

ataacgctgt gctgcagtgc ctcaagggga cctcagatgg ccccactcag cagctgacct     3600

ggtctcggga gtccccgctt aaacccttct taaaactcag cctggggctg ccaggcctgg     3660

gaatccacat gaggcccctg gcatcctggc ttttcatctt caacgtctct caacagatgg     3720

ggggcttcta cctgtgccag ccggggcccc cctctgagaa ggcctggcag cctggctgga     3780

cagtcaatgt ggagggcagc ggggagctgt tccggtggaa tgtttcggac ctaggtggcc     3840

tgggctgtgg cctgaagaac aggtcctcag agggccccag ctccccttcc gggaagctca     3900

tgagccccaa gctgtatgtg tgggccaaag accgccctga gatctgggag ggagagcctc     3960

cgtgtgtccc accgagggac agcctgaacc agagcctcag ccaggacctc accatggccc     4020

ctggctccac actctggctg tcctgtgggg taccccctga ctctgtgtcc aggggccccc     4080

tctcctggac ccatgtgcac cccaaggggc ctaagtcatt gctgagccta gagctgaagg     4140

acgatcgccc ggccagagat atgtgggtaa tggagacggg tctgttgttg ccccgggcca     4200

cagctcaaga cgctggaaag tattattgtc accgtggcaa cctgaccatg tcattccacc     4260

tggagatcac tgctcggcca gtactatggc actggctgct gaggactggt ggctggaagg     4320

tctcagctgt gactttggct tatctgatct tctgcctgtg ttcccttgtg ggcattcttc     4380

atcttgccgg cggggctgca gggatggcgg cccggcgcgg ggctctcata gtgctggagg     4440

gcgtggaccg cgccgggaag agcacgcaga gccgcaagct ggtggaagcg ctgtgcgccg     4500

cgggccaccg cgccgaactg ctccggttcc cggaaagatc aactgaaatc ggcaaacttc     4560

tgagttccta cttgcaaaag aaaagtgacg tggaggatca ctcggtgcac ctgctttttt     4620

ctgcaaatcg ctgggaacaa gtgccgttaa ttaaggaaaa gttgagccag ggcgtgaccc     4680

tcgtcgtgga cagatacgca ttttctggtg tggcctacac aggtgccaag gagaattttt     4740

ccctagactg gtgtaaacag ccagacgtgg gccttcccaa acccgacctg gtcctgttcc     4800

tccagttaca gctggcggat gctgccaagc ggggagcgtt tggccatgag cgctatgaga     4860

acggggcttt ccaggagcgg gcgctccggt gtttccacca gctcatgaaa gacacgactt     4920

tgaactggaa gatggtggat gcttccaaaa gcatcgaagc tgtccatgag gacatccgcg     4980

tgctctctga ggacgccatc gccactgcca cagagaagcc gctgggggag ctatggaagt     5040

gaggatctcg attccccctc tccctccccc ccccctaacg ttactggccg aagccgcttg     5100

gaataaggcc ggtgtgcgtt tgtctatatg ttattttcca ccatattgcc gtcttttggc     5160

aatgtgaggg cccggaaacc tggccctgtc ttcttgacga gcattcctag gggtctttcc     5220

cctctcgcca aaggaatgca aggtctgttg aatgtcgtga aggaagcagt tcctctggaa     5280

gcttcttgaa gacaaacaac gtctgtagcg accctttgca ggcagcggaa ccccccacct     5340

ggcgacaggt gcctctgcgg ccaaaagcca cgtgtataag atacacctgc aaaggcggca     5400

caaccccagt gccacgttgt gagttggata gttgtggaaa gagtcaaatg gctctcctca     5460

agcgtattca acaaggggct gaaggatgcc cagaaggtac cccattgtat gggatctgat     5520

ctggggcctc ggtgcacatg ctttacatgt gtttagtcga ggttaaaaaa acgtctaggc     5580

cccccgaacc acggggacgt ggttttcctt tgaaaaacac gattctagaa tgcggatctt     5640

cgccgtgttc attttcatga cctactggca cctgctgaac gccttcaccg tgaccgtgcc     5700

caaagatctg tacgtggtgg agtacggcag caacatgaca atcgaatgta aatttcccgt     5760

ggagaagcag ctggacctgg ccgccctgat cgtgtactgg gagatggagg ataagaatat     5820

catccagttc gtgcacggcg aggaggacct gaaagtgcag cactctagct acaggcagcg     5880

ggcaagactg ctcaaggacc agctgagcct ggggaacgcc gccctccaga tcaccgacgt     5940

gaaactccag gacgcagggg tgtatcggtg catgattagc tacggcggcg ccgactataa     6000

acgcatcaca gtgaaggtga acgcccccta caataagatc aaccagagaa tcctggtggt     6060

ggaccccgtg acctctgagc acgaactgac atgccaggcc gagggctatc caaaagccga     6120

agtgatctgg accagcagcg accaccaggt gctgtctggg aagacaacaa ccaccaattc     6180

caagcgggag gagaagctgt tcaacgtgac aagcacactg cggatcaata caaccaccaa     6240

cgagatcttc tactgtacat ttcggcgcct cgatcccgag gagaaccaca ccgccgagct     6300

ggtcatccct gaactgcccc tggctcaccc accaaacgag cggacccacc tcgtgatcct     6360

gggcgccatc ctgctgtgcc tgggcgtggc cctgaccttt atctttcggc tgagaaaggg     6420

ccggatgatg gacgtgaaga aatgcggcat ccaggacacc aacagcaaga agcagagcga     6480

tacccacctg gaagaaacct gaggatccaa gcttcaattg tggtcactcg acaatcaacc     6540

tctggattac aaaatttgtg aaagattgac tggtattctt aactatgttg ctccttttac     6600

gctatgtgga tacgctgctt taatgccttt gtatcatgct attgcttccc gtatggcttt     6660

cattttctcc tccttgtata aatcctggtt gctgtctctt tatgaggagt tgtggcccgt     6720

tgtcaggcaa cgtggcgtgg tgtgcactgt gtttgctgac gcaaccccca ctggttgggg     6780

cattgccacc acctgtcagc tcctttccgg gactttcgct ttccccctcc ctattgccac     6840

ggcggaactc atcgccgcct gccttgcccg ctgctggaca ggggctcggc tgttgggcac     6900

tgacaattcc gtggtgttgt cggggaagct gacgtccttt ccatggctgc tcgcctgtgt     6960

tgccacctgg attctgcgcg ggacgtcctt ctgctacgtc ccttcggccc tcaatccagc     7020

ggaccttcct tcccgcggcc tgctgccggc tctgcggcct cttccgcgtc ttcgccttcg     7080

ccctcagacg agtcggatct ccctttgggc cgcctccccg cctgctcgag acctagaaaa     7140

acatggagca atcacaagta gcaatacagc agctaccaat gctgattgtg cctggctaga     7200

agcacaagag gaggaggagg tgggttttcc agtcacacct caggtacctt taagaccaat     7260

gacttacaag gcagctgtag atcttagcca ctttttaaaa gaaaaggggg gactggaagg     7320

gctaattcac tcccaacgaa gacaagatct gctttttgct tgtactgggt ctctctggtt     7380

agaccagatc tgagcctggg agctctctgg ctaactaggg aacccactgc ttaagcctca     7440

ataaagcttg ccttgagtgc ttcaagtagt gtgtgcccgt ctgttgtgtg actctggtaa     7500

ctagagatcc ctcagaccct tttagtcagt gtggaaaatc tctagcagta gtagttcatg     7560

tcatcttatt attcagtatt tataacttgc aaagaaatga atatcagaga gtgagaggac     7620

gcgttggatg catagcttga gtattctata gtgtcaccta aatagcttgg cgtaatcatg     7680

gtcatagctg tttcctgtgt gaaattgtta tccgctcaca attccacaca acatacgagc     7740

cggaagcata aagtgtaaag cctggggtgc ctaatgagtg agctaactca cattaattgc     7800

gttgcgctca ctgcccgctt tccagtcggg aaacctgtcg tgccagctgc attaatgaat     7860

cggccaacgc gcggggagag gcggtttgcg tattgggcgc tcttccgctt cctcgctcac     7920

tgactcgctg cgctcggtcg ttcggctgcg gcgagcggta tcagctcact caaaggcggt     7980

aatacggtta tccacagaat caggggataa cgcaggaaag aacatgtgag caaaaggcca     8040

gcaaaaggcc aggaaccgta aaaaggccgc gttgctggcg tttttccata ggctccgccc     8100

ccctgacgag catcacaaaa atcgacgctc aagtcagagg tggcgaaacc cgacaggact     8160

ataaagatac caggcgtttc cccctggaag ctccctcgtg cgctctcctg ttccgaccct     8220

gccgcttacc ggatacctgt ccgcctttct cccttcggga agcgtggcgc tttctcatag     8280

ctcacgctgt aggtatctca gttcggtgta ggtcgttcgc tccaagctgg gctgtgtgca     8340

cgaacccccc gttcagcccg accgctgcgc cttatccggt aactatcgtc ttgagtccaa     8400

cccggtaaga cacgacttat cgccactggc agcagccact ggtaacagga ttagcagagc     8460

gaggtatgta ggcggtgcta cagagttctt gaagtggtgg cctaactacg gctacactag     8520

aagaacagta tttggtatct gcgctctgct gaagccagtt accttcggaa aaagagttgg     8580

tagctcttga tccggcaaac aaaccaccgc tggtagcggt ggtttttttg tttgcaagca     8640

gcagattacg cgcagaaaaa aaggatctca agaagatcct ttgatctttt ctacggggtc     8700

tgacgctcag tggaacgaaa actcacgtta agggattttg gtcatgagat tatcaaaaag     8760

gatcttcacc tagatccttt taaattaaaa atgaagtttt aaatcaatct aaagtatata     8820

tgagtaaact tggtctgaca gttaccaatg cttaatcagt gaggcaccta tctcagcgat     8880

ctgtctattt cgttcatcca tagttgcctg actccccgtc gtgtagataa ctacgatacg     8940

ggagggctta ccatctggcc ccagtgctgc aatgataccg cgagacccac gctcaccggc     9000

tccagattta tcagcaataa accagccagc cggaagggcc gagcgcagaa gtggtcctgc     9060

aactttatcc gcctccatcc agtctattaa ttgttgccgg gaagctagag taagtagttc     9120

gccagttaat agtttgcgca acgttgttgc cattgctaca ggcatcgtgg tgtcacgctc     9180

gtcgtttggt atggcttcat tcagctccgg ttcccaacga tcaaggcgag ttacatgatc     9240

ccccatgttg tgcaaaaaag cggttagctc cttcggtcct ccgatcgttg tcagaagtaa     9300

gttggccgca gtgttatcac tcatggttat ggcagcactg cataattctc ttactgtcat     9360

gccatccgta agatgctttt ctgtgactgg tgagtactca accaagtcat tctgagaata     9420

gtgtatgcgg cgaccgagtt gctcttgccc ggcgtcaata cgggataata ccgcgccaca     9480

tagcagaact ttaaaagtgc tcatcattgg aaaacgttct tcggggcgaa aactctcaag     9540

gatcttaccg ctgttgagat ccagttcgat gtaacccact cgtgcaccca actgatcttc     9600

agcatctttt actttcacca gcgtttctgg gtgagcaaaa acaggaaggc aaaatgccgc     9660

aaaaaaggga ataagggcga cacggaaatg ttgaatactc atactcttcc tttttcaata     9720

ttattgaagc atttatcagg gttattgtct catgagcgga tacatatttg aatgtattta     9780

gaaaaataaa caaatagggg ttccgcgcac atttccccga aaagtgccac ctgatgcggt     9840

gtgaaatacc gcacagatgc gtaaggagaa aataccgcat caggaaattg taagcgttaa     9900

tattttgtta aaattcgcgt taaatttttg ttaaatcagc tcatttttta accaataggc     9960

cgaaatcggc aaaatccctt ataaatcaaa agaatagacc gagatagggt tgagtgttgt    10020

tccagtttgg aacaagagtc cactattaaa gaacgtggac tccaacgtca aagggcgaaa    10080

aaccgtctat cagggcgatg gcccactacg tgaaccatca ccctaatcaa gttttttggg    10140

gtcgaggtgc cgtaaagcac taaatcggaa ccctaaaggg agcccccgat ttagagcttg    10200

acggggaaag ccggcgaacg tggcgagaaa ggaagggaag aaagcgaaag gagcgggcgc    10260

tagggcgctg gcaagtgtag cggtcacgct gcgcgtaacc accacacccg ccgcgcttaa    10320

tgcgccgcta cagggcgcgt ccattcgcca ttcaggctgc gcaactgttg ggaagggcga    10380

tcggtgcggg cctcttcgct attacgccag ctggcgaaag ggggatgtgc tgcaaggcga    10440

ttaagttggg taacgccagg gttttcccag tcacgacgtt gtaaaacgac ggccagtgaa    10500

ttgtaatacg actcactata                                                10520


<210>  8
<211>  1179
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide

<400>  8
ggctccggtg cccgtcagtg ggcagagcgc acatcgccca cagtccccga gaagttgggg       60

ggaggggtcg gcaattgaac cggtgcctag agaaggtggc gcggggtaaa ctgggaaagt      120

gatgtcgtgt actggctccg cctttttccc gagggtgggg gagaaccgta tataagtgca      180

gtagtcgccg tgaacgttct ttttcgcaac gggtttgccg ccagaacaca ggtaagtgcc      240

gtgtgtggtt cccgcgggcc tggcctcttt acgggttatg gcccttgcgt gccttgaatt      300

acttccacct ggctgcagta cgtgattctt gatcccgagc ttcgggttgg aagtgggtgg      360

gagagttcga ggccttgcgc ttaaggagcc ccttcgcctc gtgcttgagt tgaggcctgg      420

cctgggcgct ggggccgccg cgtgcgaatc tggtggcacc ttcgcgcctg tctcgctgct      480

ttcgataagt ctctagccat ttaaaatttt tgatgacctg ctgcgacgct ttttttctgg      540

caagatagtc ttgtaaatgc gggccaagat ctgcacactg gtatttcggt ttttggggcc      600

gcgggcggcg acggggcccg tgcgtcccag cgcacatgtt cggcgaggcg gggcctgcga      660

gcgcggccac cgagaatcgg acgggggtag tctcaagctg gccggcctgc tctggtgcct      720

ggcctcgcgc cgccgtgtat cgccccgccc tgggcggcaa ggctggcccg gtcggcacca      780

gttgcgtgag cggaaagatg gccgcttccc ggccctgctg cagggagctc aaaatggagg      840

acgcggcgct cgggagagcg ggcgggtgag tcacccacac aaaggaaaag ggcctttccg      900

tcctcagccg tcgcttcatg tgactccacg gagtaccggg cgccgtccag gcacctcgat      960

tagttctcga gcttttggag tacgtcgtct ttaggttggg gggaggggtt ttatgcgatg     1020

gagtttcccc acactgagtg ggtggagact gaagttaggc cagcttggca cttgatgtaa     1080

ttctccttgg aatttgccct ttttgagttt ggatcttggt tcattctcaa gcctcagaca     1140

gtggttcaaa gtttttttct tccatttcag gtgtcgtga                            1179


<210>  9
<211>  28
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide

<400>  9
cacaaatttt gtaatccaga ggttgatt                                          28


<210>  10
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide

<400>  10
ctagggaaaa attctccttg gca                                               23


<210>  11
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide

<400>  11
acacggcgaa gatccgcat                                                    19


<210>  12
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide

<400>  12
tcctggctga ggctctggtt                                                   20


<210>  13
<211>  639
<212>  DNA
<213>  Homo sapiens


<220>
<221>  misc_feature
<223>  TMPK

<400>  13
atggcggccc ggcgcggggc tctcatagtg ctggagggcg tggaccgcgc cgggaagagc       60

acgcagagcc gcaagctggt ggaagcgctg tgcgccgcgg gccaccgcgc cgaactgctc      120

cggttcccgg aaagatcaac tgaaatcggc aaacttctga gttcctactt gcaaaagaaa      180

agtgacgtgg aggatcactc ggtgcacctg cttttttctg caaatcgctg ggaacaagtg      240

ccgttaatta aggaaaagtt gagccagggc gtgaccctcg tcgtggacag atacgcattt      300

tctggtgtgg ccttcaccgg tgccaaggag aatttttccc tagattggtg taaacagcca      360

gacgtgggcc ttcccaaacc cgacctggtc ctgttcctcc agttacagct ggcggatgct      420

gccaagcggg gagcgtttgg ccatgagcgc tatgagaacg gggctttcca ggagcgggcg      480

ctccggtgtt tccaccagct catgaaagac acgactttga actggaagat ggtggatgct      540

tccaaaagca tcgaagctgt ccatgaggac atccgcgtgc tctctgagga cgccatccgc      600

actgccacag agaagccgct gggggagcta tggaagtga                             639


<210>  14
<211>  212
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<223>  TMPK

<400>  14

Met Ala Ala Arg Arg Gly Ala Leu Ile Val Leu Glu Gly Val Asp Arg 
1               5                   10                  15      


Ala Gly Lys Ser Thr Gln Ser Arg Lys Leu Val Glu Ala Leu Cys Ala 
            20                  25                  30          


Ala Gly His Arg Ala Glu Leu Leu Arg Phe Pro Glu Arg Ser Thr Glu 
        35                  40                  45              


Ile Gly Lys Leu Leu Ser Ser Tyr Leu Gln Lys Lys Ser Asp Val Glu 
    50                  55                  60                  


Asp His Ser Val His Leu Leu Phe Ser Ala Asn Arg Trp Glu Gln Val 
65                  70                  75                  80  


Pro Leu Ile Lys Glu Lys Leu Ser Gln Gly Val Thr Leu Val Val Asp 
                85                  90                  95      


Arg Tyr Ala Phe Ser Gly Val Ala Phe Thr Gly Ala Lys Glu Asn Phe 
            100                 105                 110         


Ser Leu Asp Trp Cys Lys Gln Pro Asp Val Gly Leu Pro Lys Pro Asp 
        115                 120                 125             


Leu Val Leu Phe Leu Gln Leu Gln Leu Ala Asp Ala Ala Lys Arg Gly 
    130                 135                 140                 


Ala Phe Gly His Glu Arg Tyr Glu Asn Gly Ala Phe Gln Glu Arg Ala 
145                 150                 155                 160 


Leu Arg Cys Phe His Gln Leu Met Lys Asp Thr Thr Leu Asn Trp Lys 
                165                 170                 175     


Met Val Asp Ala Ser Lys Ser Ile Glu Ala Val His Glu Asp Ile Arg 
            180                 185                 190         


Val Leu Ser Glu Asp Ala Ile Arg Thr Ala Thr Glu Lys Pro Leu Gly 
        195                 200                 205             


Glu Leu Trp Lys 
    210         


<210>  15
<211>  639
<212>  DNA
<213>  Homo sapiens


<220>
<221>  misc_feature
<223>  TMPK

<400>  15
atggcggccc ggcgcggggc tctcatagtg ctggagggcg tggaccgcgc cgggaagagc       60

acgcagagcc gcaagctggt ggaagcgctg tgcgccgcgg gccaccgcgc cgaactgctc      120

cggttcccgg aaagatcaac tgaaatcggc aaacttctga gttcctactt gcaaaagaaa      180

agtgacgtgg aggatcactc ggtgcacctg cttttttctg caaatcgctg ggaacaagtg      240

ccgttaatta aggaaaagtt gagccagggc gtgaccctcg tcgtggacag atacgcattt      300

tctggtgtgg ccttcaccgg tgccaaggag aatttttccc tagattggtg taaacagcca      360

gacgtgggcc ttcccaaacc cgacctggtc ctgttcctcc agttacagct ggcggatgct      420

gccaagcggg gagcgtttgg ccatgagcgc tatgagaacg gggctttcca ggagcgggcg      480

ctccggtgtt tccaccagct catgaaagac acgactttga actggaagat ggtggatgct      540

tccaaaagca tcgaagctgt ccatgaggac atccgcgtgc tctctgagga cgccatccgc      600

actgccacag agaagccgct gggggagcta tggaagtga                             639


<210>  16
<211>  212
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<223>  TMPK

<400>  16

Met Ala Ala Arg Arg Gly Ala Leu Ile Val Leu Glu Gly Val Asp Arg 
1               5                   10                  15      


Ala Gly Lys Ser Thr Gln Ser Arg Lys Leu Val Glu Ala Leu Cys Ala 
            20                  25                  30          


Ala Gly His Arg Ala Glu Leu Leu Arg Phe Pro Glu Arg Ser Thr Glu 
        35                  40                  45              


Ile Gly Lys Leu Leu Ser Ser Tyr Leu Gln Lys Lys Ser Asp Val Glu 
    50                  55                  60                  


Asp His Ser Val His Leu Leu Phe Ser Ala Asn Arg Trp Glu Gln Val 
65                  70                  75                  80  


Pro Leu Ile Lys Glu Lys Leu Ser Gln Gly Val Thr Leu Val Val Asp 
                85                  90                  95      


Arg Tyr Ala Phe Ser Gly Val Ala Phe Thr Gly Ala Lys Glu Asn Phe 
            100                 105                 110         


Ser Leu Asp Trp Cys Lys Gln Pro Asp Val Gly Leu Pro Lys Pro Asp 
        115                 120                 125             


Leu Val Leu Phe Leu Gln Leu Gln Leu Ala Asp Ala Ala Lys Arg Gly 
    130                 135                 140                 


Ala Phe Gly His Glu Arg Tyr Glu Asn Gly Ala Phe Gln Glu Arg Ala 
145                 150                 155                 160 


Leu Arg Cys Phe His Gln Leu Met Lys Asp Thr Thr Leu Asn Trp Lys 
                165                 170                 175     


Met Val Asp Ala Ser Lys Ser Ile Glu Ala Val His Glu Asp Ile Arg 
            180                 185                 190         


Val Leu Ser Glu Asp Ala Ile Arg Thr Ala Thr Glu Lys Pro Leu Gly 
        195                 200                 205             


Glu Leu Trp Lys 
    210         


<210>  17
<211>  636
<212>  DNA
<213>  Homo sapiens


<220>
<221>  misc_feature
<223>  TMPK

<400>  17
atggcggccc ggcgcggggc tctcatagtg ctggagggcg tggaccgcgc cgggaagagc       60

acgcagagcc gcaagctggt ggaagcgctg tcgcgcgggc caccgcccga actgctccgg      120

ttcccggaaa gatcaactga aatcggcaaa cttctgagtt cctacttgca aaagaaaagt      180

gacgtggagg atcactcggt gcacctgctt ttttctgcaa atcgctggga acaagtgccg      240

ttaattaagg aaaagttgag ccagggcgtg accctcgtcg tggacagata cgcattttct      300

ggtgtggcct tcaccggtgc caaggagaat ttttccctag actggtgtaa acagccagac      360

gtgggccttc ccaaacccga cctggtcctg ttcctccagt tacagctggc ggatgctgcc      420

aagcggggag cgtttggcca tgagcgctat gagaacgggg ctttccagga gcgggcgctc      480

cggtgtttcc accagctcat gaaagacacg actttgaact ggaagatggt ggatgcttcc      540

aaaagactcg aagctgtcca tgaggaactc cgcgtgctct ctgaggacgc catccgcact      600

gccacagaga agccgctggg ggagctatgg aagtga                                636


<210>  18
<211>  211
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<223>  TMPK

<400>  18

Met Ala Ala Arg Arg Gly Ala Leu Ile Val Leu Glu Gly Val Asp Arg 
1               5                   10                  15      


Ala Gly Lys Ser Thr Gln Ser Arg Lys Leu Val Glu Ala Leu Ser Arg 
            20                  25                  30          


Gly Pro Pro Pro Glu Leu Leu Arg Phe Pro Glu Arg Ser Thr Glu Ile 
        35                  40                  45              


Gly Lys Leu Leu Ser Ser Tyr Leu Gln Lys Lys Ser Asp Val Glu Asp 
    50                  55                  60                  


His Ser Val His Leu Leu Phe Ser Ala Asn Arg Trp Glu Gln Val Pro 
65                  70                  75                  80  


Leu Ile Lys Glu Lys Leu Ser Gln Gly Val Thr Leu Val Val Asp Arg 
                85                  90                  95      


Tyr Ala Phe Ser Gly Val Ala Phe Thr Gly Ala Lys Glu Asn Phe Ser 
            100                 105                 110         


Leu Asp Trp Cys Lys Gln Pro Asp Val Gly Leu Pro Lys Pro Asp Leu 
        115                 120                 125             


Val Leu Phe Leu Gln Leu Gln Leu Ala Asp Ala Ala Lys Arg Gly Ala 
    130                 135                 140                 


Phe Gly His Glu Arg Tyr Glu Asn Gly Ala Phe Gln Glu Arg Ala Leu 
145                 150                 155                 160 


Arg Cys Phe His Gln Leu Met Lys Asp Thr Thr Leu Asn Trp Lys Met 
                165                 170                 175     


Val Asp Ala Ser Lys Arg Leu Glu Ala Val His Glu Glu Leu Arg Val 
            180                 185                 190         


Leu Ser Glu Asp Ala Ile Arg Thr Ala Thr Glu Lys Pro Leu Gly Glu 
        195                 200                 205             


Leu Trp Lys 
    210     


<210>  19
<211>  639
<212>  DNA
<213>  Homo sapiens


<220>
<221>  misc_feature
<223>  TMPK

<400>  19
atggcggccc ggcgcggggc tctcatagtg ctggagggcg tggaccgcgc cgggaagagc       60

acgcagagcc gcaagctggt ggaagcgctg tgcgccgcgg gccaccgcgc cgaactgctc      120

cggttcccgg aaagatcaac tgaaatcggc aaacttctga gttcctactt gcaaaagaaa      180

agtgacgtgg aggatcactc ggtgcacctg cttttttctg caaatcgctg ggaacaagtg      240

ccgttaatta aggaaaagtt gagccagggc gtgaccctcg tcgtggacag atacgcattt      300

tctggtgtgg ccttcaccgg tgccaaggag aatttttccc tagattggtg taaacagcca      360

gacgtgggcc ttcccaaacc cgacctggtc ctgttcctcc agttacagct ggcggatgct      420

gccaagcggg gagcgtttgg ccatgagcgc tatgagaacg gggctttcca ggagcgggcg      480

ctccggtgtt tccaccagct catgaaagac acgactttga actggaagat ggtggatgct      540

tccaaaagca tcgaagctgt ccatgaggac atccgcgtgc tctctgagga cgccatccgc      600

actgccacag agaagccgct gggggagcta tggaaggac                             639


<210>  20
<211>  213
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<223>  TMPK

<400>  20

Met Ala Ala Arg Arg Gly Ala Leu Ile Val Leu Glu Gly Val Asp Arg 
1               5                   10                  15      


Ala Gly Lys Ser Thr Gln Ser Arg Lys Leu Val Glu Ala Leu Cys Ala 
            20                  25                  30          


Ala Gly His Arg Ala Glu Leu Leu Arg Phe Pro Glu Arg Ser Thr Glu 
        35                  40                  45              


Ile Gly Lys Leu Leu Ser Ser Tyr Leu Gln Lys Lys Ser Asp Val Glu 
    50                  55                  60                  


Asp His Ser Val His Leu Leu Phe Ser Ala Asn Arg Trp Glu Gln Val 
65                  70                  75                  80  


Pro Leu Ile Lys Glu Lys Leu Ser Gln Gly Val Thr Leu Val Val Asp 
                85                  90                  95      


Arg Tyr Ala Phe Ser Gly Val Ala Phe Thr Gly Ala Lys Glu Asn Phe 
            100                 105                 110         


Ser Leu Asp Trp Cys Lys Gln Pro Asp Val Gly Leu Pro Lys Pro Asp 
        115                 120                 125             


Leu Val Leu Phe Leu Gln Leu Gln Leu Ala Asp Ala Ala Lys Arg Gly 
    130                 135                 140                 


Ala Phe Gly His Glu Arg Tyr Glu Asn Gly Ala Phe Gln Glu Arg Ala 
145                 150                 155                 160 


Leu Arg Cys Phe His Gln Leu Met Lys Asp Thr Thr Leu Asn Trp Lys 
                165                 170                 175     


Met Val Asp Ala Ser Lys Ser Ile Glu Ala Val His Glu Asp Ile Arg 
            180                 185                 190         


Val Leu Ser Glu Asp Ala Ile Arg Thr Ala Thr Glu Lys Pro Leu Gly 
        195                 200                 205             


Glu Leu Trp Lys Asp 
    210             


<210>  21
<211>  639
<212>  DNA
<213>  Mus musculus


<220>
<221>  misc_feature
<223>  TMPK

<400>  21
atggcgtcgc gtcggggagc gctcatcgtg ctggagggtg tggaccgtgc tggcaagacc       60

acgcagggcc tcaagctggt gaccgcgctg tgcgcctcgg gccacagagc ggagctgctg      120

cgtttccccg aaagatcaac ggaaatcggc aagcttctga attcctactt ggaaaagaaa      180

acggaactag aggatcactc cgtgcacctg ctcttctctg caaaccgctg ggaacaagta      240

ccattaatta aggcgaagtt gaaccagggt gtgacccttg ttttggacag atacgccttt      300

tctggggttg ccttcactgg tgccaaagag aatttttccc tggattggtg taaacaaccg      360

gacgtgggcc ttcccaaacc tgacctgatc ctgttccttc agttacaatt gctggacgct      420

gctgcacggg gagagtttgg ccttgagcga tatgagaccg ggactttcca aaagcaggtt      480

ctgttgtgtt tccagcagct catggaagag aaaaacctca actggaaggt ggttgatgct      540

tccaaaagca ttgaggaagt ccataaagaa atccgtgcac actctgagga cgccatccga      600

aacgctgcac agaggccact gggggagcta tggaaataa                             639


<210>  22
<211>  212
<212>  PRT
<213>  Mus musculus


<220>
<221>  MISC_FEATURE
<223>  TMPK

<400>  22

Met Ala Ser Arg Arg Gly Ala Leu Ile Val Leu Glu Gly Val Asp Arg 
1               5                   10                  15      


Ala Gly Lys Thr Thr Gln Gly Leu Lys Leu Val Thr Ala Leu Cys Ala 
            20                  25                  30          


Ser Gly His Arg Ala Glu Leu Leu Arg Phe Pro Glu Arg Ser Thr Glu 
        35                  40                  45              


Ile Gly Lys Leu Leu Asn Ser Tyr Leu Glu Lys Lys Thr Glu Leu Glu 
    50                  55                  60                  


Asp His Ser Val His Leu Leu Phe Ser Ala Asn Arg Trp Glu Gln Val 
65                  70                  75                  80  


Pro Leu Ile Lys Ala Lys Leu Asn Gln Gly Val Thr Leu Val Leu Asp 
                85                  90                  95      


Arg Tyr Ala Phe Ser Gly Val Ala Phe Thr Gly Ala Lys Glu Asn Phe 
            100                 105                 110         


Ser Leu Asp Trp Cys Lys Gln Pro Asp Val Gly Leu Pro Lys Pro Asp 
        115                 120                 125             


Leu Ile Leu Phe Leu Gln Leu Gln Leu Leu Asp Ala Ala Ala Arg Gly 
    130                 135                 140                 


Glu Phe Gly Leu Glu Arg Tyr Glu Thr Gly Thr Phe Gln Lys Gln Val 
145                 150                 155                 160 


Leu Leu Cys Phe Gln Gln Leu Met Glu Glu Lys Asn Leu Asn Trp Lys 
                165                 170                 175     


Val Val Asp Ala Ser Lys Ser Ile Glu Glu Val His Lys Glu Ile Arg 
            180                 185                 190         


Ala His Ser Glu Asp Ala Ile Arg Asn Ala Ala Gln Arg Pro Leu Gly 
        195                 200                 205             


Glu Leu Trp Lys 
    210         


<210>  23
<211>  212
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<223>  TMPK variant

<400>  23

Met Ala Ala Arg Arg Gly Ala Leu Ile Val Leu Glu Gly Val Asp Arg 
1               5                   10                  15      


Ala Gly Lys Ser Thr Gln Ser Arg Lys Leu Val Glu Ala Leu Cys Ala 
            20                  25                  30          


Ala Gly His Arg Ala Glu Leu Leu Arg Phe Pro Glu Arg Ser Thr Glu 
        35                  40                  45              


Ile Gly Lys Leu Leu Ser Ser Tyr Leu Gln Lys Lys Ser Asp Val Glu 
    50                  55                  60                  


Asp His Ser Val His Leu Leu Phe Ser Ala Asn Arg Trp Glu Gln Val 
65                  70                  75                  80  


Pro Leu Ile Lys Glu Lys Leu Ser Gln Gly Val Thr Leu Val Val Asp 
                85                  90                  95      


Arg Tyr Ala Phe Ser Gly Val Ala Tyr Thr Gly Ala Lys Glu Asn Phe 
            100                 105                 110         


Ser Leu Asp Trp Cys Lys Gln Pro Asp Val Gly Leu Pro Lys Pro Asp 
        115                 120                 125             


Leu Val Leu Phe Leu Gln Leu Gln Leu Ala Asp Ala Ala Lys Arg Gly 
    130                 135                 140                 


Ala Phe Gly His Glu Arg Tyr Glu Asn Gly Ala Phe Gln Glu Arg Ala 
145                 150                 155                 160 


Leu Arg Cys Phe His Gln Leu Met Lys Asp Thr Thr Leu Asn Trp Lys 
                165                 170                 175     


Met Val Asp Ala Ser Lys Ser Ile Glu Ala Val His Glu Asp Ile Arg 
            180                 185                 190         


Val Leu Ser Glu Asp Ala Ile Arg Thr Ala Thr Glu Lys Pro Leu Gly 
        195                 200                 205             


Glu Leu Trp Lys 
    210         


<210>  24
<211>  214
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<223>  TMPK variant

<400>  24

Met Ala Ala Arg Arg Gly Ala Leu Ile Val Leu Glu Gly Val Asp Gly 
1               5                   10                  15      


Ala Gly Lys Ser Thr Gln Ser Arg Lys Leu Val Glu Ala Leu Cys Ala 
            20                  25                  30          


Ala Gly His Arg Ala Glu Leu Leu Arg Phe Pro Glu Arg Ser Thr Glu 
        35                  40                  45              


Ile Gly Lys Leu Leu Ser Ser Tyr Leu Gln Lys Lys Ser Asp Val Glu 
    50                  55                  60                  


Asp His Ser Val His Leu Leu Phe Ser Ala Asn Arg Trp Glu Gln Val 
65                  70                  75                  80  


Pro Leu Ile Lys Glu Lys Leu Ser Gln Gly Val Thr Leu Val Val Asp 
                85                  90                  95      


Arg Tyr Ala Phe Ser Gly Val Ala Phe Thr Gly Ala Lys Glu Asn Phe 
            100                 105                 110         


Ser Leu Asp Trp Cys Lys Gln Pro Asp Val Gly Leu Pro Lys Pro Asp 
        115                 120                 125             


Leu Val Leu Phe Leu Gln Leu Thr Pro Glu Val Gly Leu Lys Arg Ala 
    130                 135                 140                 


Arg Ala Arg Gly Glu Leu Asp Arg Tyr Glu Asn Gly Ala Phe Gln Glu 
145                 150                 155                 160 


Arg Ala Leu Arg Cys Phe His Gln Leu Met Lys Asp Thr Thr Leu Asn 
                165                 170                 175     


Trp Lys Met Val Asp Ala Ser Lys Ser Ile Glu Ala Val His Glu Asp 
            180                 185                 190         


Ile Arg Val Leu Ser Glu Asp Ala Ile Ala Thr Ala Thr Glu Lys Pro 
        195                 200                 205             


Leu Gly Glu Leu Trp Lys 
    210                 


<210>  25
<211>  639
<212>  DNA
<213>  Homo sapiens


<220>
<221>  misc_feature
<223>  TMPK variant

<400>  25
atggcggccc ggcgcggggc tctcatagtg ctggagggcg tggaccgcgc cgggaagagc       60

acgcagagcc gcaagctggt ggaagcgctg tgcgccgcgg gccaccgcgc cgaactgctc      120

cggttcccgg aaagatcaac tgaaatcggc aaacttctga gttcctactt gcaaaagaaa      180

agtgacgtgg aggatcactc ggtgcacctg cttttttctg caaatcgctg ggaacaagtg      240

ccgttaatta aggaaaagtt gagccagggc gtgaccctcg tcgtggacag atacgcattt      300

tctggtgtgg ccttcacagg tgccaaggag aatttttccc tagactggtg taaacagcca      360

gacgtgggcc ttcccaaacc cgacctggtc ctgttcctcc agttacagct ggcggatgct      420

gccaagcggg gagcgtttgg ccatgagcgc tatgagaacg gggctttcca ggagcgggcg      480

ctccggtgtt tccaccagct catgaaagac acgactttga actggaagat ggtggatgct      540

tccaaaagca tcgaagctgt ccatgaggac atccgcgtgc tctctgagga cgccatcgcc      600

actgccacag agaagccgct gggggagcta tggaagtga                             639


<210>  26
<211>  212
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<223>  TMPK variant

<400>  26

Met Ala Ala Arg Arg Gly Ala Leu Ile Val Leu Glu Gly Val Asp Arg 
1               5                   10                  15      


Ala Gly Lys Ser Thr Gln Ser Arg Lys Leu Val Glu Ala Leu Cys Ala 
            20                  25                  30          


Ala Gly His Arg Ala Glu Leu Leu Arg Phe Pro Glu Arg Ser Thr Glu 
        35                  40                  45              


Ile Gly Lys Leu Leu Ser Ser Tyr Leu Gln Lys Lys Ser Asp Val Glu 
    50                  55                  60                  


Asp His Ser Val His Leu Leu Phe Ser Ala Asn Arg Trp Glu Gln Val 
65                  70                  75                  80  


Pro Leu Ile Lys Glu Lys Leu Ser Gln Gly Val Thr Leu Val Val Asp 
                85                  90                  95      


Arg Tyr Ala Phe Ser Gly Val Ala Phe Thr Gly Ala Lys Glu Asn Phe 
            100                 105                 110         


Ser Leu Asp Trp Cys Lys Gln Pro Asp Val Gly Leu Pro Lys Pro Asp 
        115                 120                 125             


Leu Val Leu Phe Leu Gln Leu Gln Leu Ala Asp Ala Ala Lys Arg Gly 
    130                 135                 140                 


Ala Phe Gly His Glu Arg Tyr Glu Asn Gly Ala Phe Gln Glu Arg Ala 
145                 150                 155                 160 


Leu Arg Cys Phe His Gln Leu Met Lys Asp Thr Thr Leu Asn Trp Lys 
                165                 170                 175     


Met Val Asp Ala Ser Lys Ser Ile Glu Ala Val His Glu Asp Ile Arg 
            180                 185                 190         


Val Leu Ser Glu Asp Ala Ile Ala Thr Ala Thr Glu Lys Pro Leu Gly 
        195                 200                 205             


Glu Leu Trp Lys 
    210         


<210>  27
<211>  592
<212>  DNA
<213>  Woodchuck hepatitis virus

<400>  27
aatcaacctc tggattacaa aatttgtgaa agattgactg gtattcttaa ctatgttgct       60

ccttttacgc tatgtggata cgctgcttta atgcctttgt atcatgctat tgcttcccgt      120

atggctttca ttttctcctc cttgtataaa tcctggttgc tgtctcttta tgaggagttg      180

tggcccgttg tcaggcaacg tggcgtggtg tgcactgtgt ttgctgacgc aacccccact      240

ggttggggca ttgccaccac ctgtcagctc ctttccggga ctttcgcttt ccccctccct      300

attgccacgg cggaactcat cgccgcctgc cttgcccgct gctggacagg ggctcggctg      360

ttgggcactg acaattccgt ggtgttgtcg gggaagctga cgtcctttcc atggctgctc      420

gcctgtgttg ccacctggat tctgcgcggg acgtccttct gctacgtccc ttcggccctc      480

aatccagcgg accttccttc ccgcggcctg ctgccggctc tgcggcctct tccgcgtctt      540

cgccttcgcc ctcagacgag tcggatctcc ctttgggccg cctccccgcc tg              592


<210>  28
<211>  639
<212>  DNA
<213>  Homo sapiens


<220>
<221>  misc_feature
<223>  TMPK variant

<400>  28
atggcggccc ggcgcggggc tctcatagtg ctggagggcg tggaccgcgc cgggaagagc       60

acgcagagcc gcaagctggt ggaagcgctg tgcgccgcgg gccaccgcgc cgaactgctc      120

cggttcccgg aaagatcaac tgaaatcggc aaacttctga gttcctactt gcaaaagaaa      180

agtgacgtgg aggatcactc ggtgcacctg cttttttctg caaatcgctg ggaacaagtg      240

ccgttaatta aggaaaagtt gagccagggc gtgaccctcg tcgtggacag atacgcattt      300

tctggtgtgg cctacacagg tgccaaggag aatttttccc tagactggtg taaacagcca      360

gacgtgggcc ttcccaaacc cgacctggtc ctgttcctcc agttacagct ggcggatgct      420

gccaagcggg gagcgtttgg ccatgagcgc tatgagaacg gggctttcca ggagcgggcg      480

ctccggtgtt tccaccagct catgaaagac acgactttga actggaagat ggtggatgct      540

tccaaaagca tcgaagctgt ccatgaggac atccgcgtgc tctctgagga cgccatcgcc      600

actgccacag agaagccgct gggggagcta tggaagtga                             639


<210>  29
<211>  645
<212>  DNA
<213>  Homo sapiens


<220>
<221>  misc_feature
<223>  TMPK variant

<400>  29
atggcggccc ggcgcggggc tctcatagtg ctggagggcg tggacggcgc cgggaagagc       60

acgcagagcc gcaagctggt ggaagcgctg tgcgccgcgg gccaccgcgc cgaactgctc      120

cggttcccgg aaagatcaac tgaaatcggc aaacttctga gttcctactt gcaaaagaaa      180

agtgacgtgg aggatcactc ggtgcacctg cttttttctg caaatcgctg ggaacaagtg      240

ccgttaatta aggaaaagtt gagccagggc gtgaccctcg tcgtggacag atacgcattt      300

tctggtgtgg ccttcaccgg tgccaaggag aatttttccc tagactggtg taaacagcca      360

gacgtgggcc ttcccaaacc cgacctggtc ctgttcctgc agttaactcc ggaagttggc      420

ttaaaacgcg cacgtgctcg cggcgagctt gaccgctatg agaacggggc tttccaggag      480

cgggcgctcc ggtgtttcca ccagctcatg aaagacacga ctttgaactg gaagatggtg      540

gatgcttcca aaagcatcga agctgtccat gaggacatcc gcgtgctctc tgaggacgcc      600

atcgccactg ccacagagaa gccgctgggg gagctatgga agtga                      645


<210>  30
<211>  1966
<212>  DNA
<213>  Homo sapiens


<220>
<221>  misc_feature
<223>  CD19

<400>  30
aggcccctgc ctgccccagc atcccctgcg cgaagctggg tgccccggag agtctgacca       60

ccatgccacc tcctcgcctc ctcttcttcc tcctcttcct cacccccatg gaagtcaggc      120

ccgaggaacc tctagtggtg aaggtggaag agggagataa cgctgtgctg cagtgcctca      180

aggggacctc agatggcccc actcagcagc tgacctggtc tcgggagtcc ccgcttaaac      240

ccttcttaaa actcagcctg gggctgccag gcctgggaat ccacatgagg cccctggcca      300

tctggctttt catcttcaac gtctctcaac agatgggggg cttctacctg tgccagccgg      360

ggcccccctc tgagaaggcc tggcagcctg gctggacagt caatgtggag ggcagcgggg      420

agctgttccg gtggaatgtt tcggacctag gtggcctggg ctgtggcctg aagaacaggt      480

cctcagaggg ccccagctcc ccttccggga agctcatgag ccccaagctg tatgtgtggg      540

ccaaagaccg ccctgagatc tgggagggag agcctccgtg tctcccaccg agggacagcc      600

tgaaccagag cctcagccag gacctcacca tggcccctgg ctccacactc tggctgtcct      660

gtggggtacc ccctgactct gtgtccaggg gccccctctc ctggacccat gtgcacccca      720

aggggcctaa gtcattgctg agcctagagc tgaaggacga tcgcccggcc agagatatgt      780

gggtaatgga gacgggtctg ttgttgcccc gggccacagc tcaagacgct ggaaagtatt      840

attgtcaccg tggcaacctg accatgtcat tccacctgga gatcactgct cggccagtac      900

tatggcactg gctgctgagg actggtggct ggaaggtctc agctgtgact ttggcttatc      960

tgatcttctg cctgtgttcc cttgtgggca ttcttcatct tcaaagagcc ctggtcctga     1020

ggaggaaaag aaagcgaatg actgacccca ccaggagatt cttcaaagtg acgcctcccc     1080

caggaagcgg gccccagaac cagtacggga acgtgctgtc tctccccaca cccacctcag     1140

gcctcggacg cgcccagcgt tgggccgcag gcctgggggg cactgccccg tcttatggaa     1200

acccgagcag cgacgtccag gcggatggag ccttggggtc ccggagcccg ccgggagtgg     1260

gcccagaaga agaggaaggg gagggctatg aggaacctga cagtgaggag gactccgagt     1320

tctatgagaa cgactccaac cttgggcagg accagctctc ccaggatggc agcggctacg     1380

agaaccctga ggatgagccc ctgggtcctg aggatgaaga ctccttctcc aacgctgagt     1440

cttatgagaa cgaggatgaa gagctgaccc agccggtcgc caggacaatg gacttcctga     1500

gccctcatgg gtcagcctgg gaccccagcc gggaagcaac ctccctgggg tcccagtcct     1560

atgaggatat gagaggaatc ctgtatgcag ccccccagct ccgctccatt cggggccagc     1620

ctggacccaa tcatgaggaa gatgcagact cttatgagaa catggataat cccgatgggc     1680

cagacccagc ctggggagga gggggccgca tgggcacctg gagcaccagg tgatcctcag     1740

gtggccagcc tggatctcct caagtcccca agattcacac ctgactctga aatctgaaga     1800

cctcgagcag atgatgccaa cctctggagc aatgttgctt aggatgtgtg catgtgtgta     1860

agtgtgtgtg tgtgtgtgtg tgtgtataca tgccagtgac acttccagtc ccctttgtat     1920

tccttaaata aactcaatga gctcttccaa aaaaaaaaaa aaaaaa                    1966


<210>  31
<211>  556
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<223>  CD19

<400>  31

Met Pro Pro Pro Arg Leu Leu Phe Phe Leu Leu Phe Leu Thr Pro Met 
1               5                   10                  15      


Glu Val Arg Pro Glu Glu Pro Leu Val Val Lys Val Glu Glu Gly Asp 
            20                  25                  30          


Asn Ala Val Leu Gln Cys Leu Lys Gly Thr Ser Asp Gly Pro Thr Gln 
        35                  40                  45              


Gln Leu Thr Trp Ser Arg Glu Ser Pro Leu Lys Pro Phe Leu Lys Leu 
    50                  55                  60                  


Ser Leu Gly Leu Pro Gly Leu Gly Ile His Met Arg Pro Leu Ala Ile 
65                  70                  75                  80  


Trp Leu Phe Ile Phe Asn Val Ser Gln Gln Met Gly Gly Phe Tyr Leu 
                85                  90                  95      


Cys Gln Pro Gly Pro Pro Ser Glu Lys Ala Trp Gln Pro Gly Trp Thr 
            100                 105                 110         


Val Asn Val Glu Gly Ser Gly Glu Leu Phe Arg Trp Asn Val Ser Asp 
        115                 120                 125             


Leu Gly Gly Leu Gly Cys Gly Leu Lys Asn Arg Ser Ser Glu Gly Pro 
    130                 135                 140                 


Ser Ser Pro Ser Gly Lys Leu Met Ser Pro Lys Leu Tyr Val Trp Ala 
145                 150                 155                 160 


Lys Asp Arg Pro Glu Ile Trp Glu Gly Glu Pro Pro Cys Leu Pro Pro 
                165                 170                 175     


Arg Asp Ser Leu Asn Gln Ser Leu Ser Gln Asp Leu Thr Met Ala Pro 
            180                 185                 190         


Gly Ser Thr Leu Trp Leu Ser Cys Gly Val Pro Pro Asp Ser Val Ser 
        195                 200                 205             


Arg Gly Pro Leu Ser Trp Thr His Val His Pro Lys Gly Pro Lys Ser 
    210                 215                 220                 


Leu Leu Ser Leu Glu Leu Lys Asp Asp Arg Pro Ala Arg Asp Met Trp 
225                 230                 235                 240 


Val Met Glu Thr Gly Leu Leu Leu Pro Arg Ala Thr Ala Gln Asp Ala 
                245                 250                 255     


Gly Lys Tyr Tyr Cys His Arg Gly Asn Leu Thr Met Ser Phe His Leu 
            260                 265                 270         


Glu Ile Thr Ala Arg Pro Val Leu Trp His Trp Leu Leu Arg Thr Gly 
        275                 280                 285             


Gly Trp Lys Val Ser Ala Val Thr Leu Ala Tyr Leu Ile Phe Cys Leu 
    290                 295                 300                 


Cys Ser Leu Val Gly Ile Leu His Leu Gln Arg Ala Leu Val Leu Arg 
305                 310                 315                 320 


Arg Lys Arg Lys Arg Met Thr Asp Pro Thr Arg Arg Phe Phe Lys Val 
                325                 330                 335     


Thr Pro Pro Pro Gly Ser Gly Pro Gln Asn Gln Tyr Gly Asn Val Leu 
            340                 345                 350         


Ser Leu Pro Thr Pro Thr Ser Gly Leu Gly Arg Ala Gln Arg Trp Ala 
        355                 360                 365             


Ala Gly Leu Gly Gly Thr Ala Pro Ser Tyr Gly Asn Pro Ser Ser Asp 
    370                 375                 380                 


Val Gln Ala Asp Gly Ala Leu Gly Ser Arg Ser Pro Pro Gly Val Gly 
385                 390                 395                 400 


Pro Glu Glu Glu Glu Gly Glu Gly Tyr Glu Glu Pro Asp Ser Glu Glu 
                405                 410                 415     


Asp Ser Glu Phe Tyr Glu Asn Asp Ser Asn Leu Gly Gln Asp Gln Leu 
            420                 425                 430         


Ser Gln Asp Gly Ser Gly Tyr Glu Asn Pro Glu Asp Glu Pro Leu Gly 
        435                 440                 445             


Pro Glu Asp Glu Asp Ser Phe Ser Asn Ala Glu Ser Tyr Glu Asn Glu 
    450                 455                 460                 


Asp Glu Glu Leu Thr Gln Pro Val Ala Arg Thr Met Asp Phe Leu Ser 
465                 470                 475                 480 


Pro His Gly Ser Ala Trp Asp Pro Ser Arg Glu Ala Thr Ser Leu Gly 
                485                 490                 495     


Ser Gln Ser Tyr Glu Asp Met Arg Gly Ile Leu Tyr Ala Ala Pro Gln 
            500                 505                 510         


Leu Arg Ser Ile Arg Gly Gln Pro Gly Pro Asn His Glu Glu Asp Ala 
        515                 520                 525             


Asp Ser Tyr Glu Asn Met Asp Asn Pro Asp Gly Pro Asp Pro Ala Trp 
    530                 535                 540                 


Gly Gly Gly Gly Arg Met Gly Thr Trp Ser Thr Arg 
545                 550                 555     


<210>  32
<211>  313
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<223>  CD19

<400>  32

Met Pro Pro Pro Arg Leu Leu Phe Phe Leu Leu Phe Leu Thr Pro Met 
1               5                   10                  15      


Glu Val Arg Pro Glu Glu Pro Leu Val Val Lys Val Glu Glu Gly Asp 
            20                  25                  30          


Asn Ala Val Leu Gln Cys Leu Lys Gly Thr Ser Asp Gly Pro Thr Gln 
        35                  40                  45              


Gln Leu Thr Trp Ser Arg Glu Ser Pro Leu Lys Pro Phe Leu Lys Leu 
    50                  55                  60                  


Ser Leu Gly Leu Pro Gly Leu Gly Ile His Met Arg Pro Leu Ala Ile 
65                  70                  75                  80  


Trp Leu Phe Ile Phe Asn Val Ser Gln Gln Met Gly Gly Phe Tyr Leu 
                85                  90                  95      


Cys Gln Pro Gly Pro Pro Ser Glu Lys Ala Trp Gln Pro Gly Trp Thr 
            100                 105                 110         


Val Asn Val Glu Gly Ser Gly Glu Leu Phe Arg Trp Asn Val Ser Asp 
        115                 120                 125             


Leu Gly Gly Leu Gly Cys Gly Leu Lys Asn Arg Ser Ser Glu Gly Pro 
    130                 135                 140                 


Ser Ser Pro Ser Gly Lys Leu Met Ser Pro Lys Leu Tyr Val Trp Ala 
145                 150                 155                 160 


Lys Asp Arg Pro Glu Ile Trp Glu Gly Glu Pro Pro Cys Leu Pro Pro 
                165                 170                 175     


Arg Asp Ser Leu Asn Gln Ser Leu Ser Gln Asp Leu Thr Met Ala Pro 
            180                 185                 190         


Gly Ser Thr Leu Trp Leu Ser Cys Gly Val Pro Pro Asp Ser Val Ser 
        195                 200                 205             


Arg Gly Pro Leu Ser Trp Thr His Val His Pro Lys Gly Pro Lys Ser 
    210                 215                 220                 


Leu Leu Ser Leu Glu Leu Lys Asp Asp Arg Pro Ala Arg Asp Met Trp 
225                 230                 235                 240 


Val Met Glu Thr Gly Leu Leu Leu Pro Arg Ala Thr Ala Gln Asp Ala 
                245                 250                 255     


Gly Lys Tyr Tyr Cys His Arg Gly Asn Leu Thr Met Ser Phe His Leu 
            260                 265                 270         


Glu Ile Thr Ala Arg Pro Val Leu Trp His Trp Leu Leu Arg Thr Gly 
        275                 280                 285             


Gly Trp Lys Val Ser Ala Val Thr Leu Ala Tyr Leu Ile Phe Cys Leu 
    290                 295                 300                 


Cys Ser Leu Val Gly Ile Leu His Leu 
305                 310             


<210>  33
<211>  939
<212>  DNA
<213>  Homo sapiens


<220>
<221>  misc_feature
<223>  CD19

<400>  33
atgccacctc ctcgcctcct cttcttcctc ctcttcctca cccccatgga agtcaggccc       60

gaggaacctc tagtggtgaa ggtggaagag ggagataacg ctgtgctgca gtgcctcaag      120

gggacctcag atggccccac tcagcagctg acctggtctc gggagtcccc gcttaaaccc      180

ttcttaaaac tcagcctggg gctgccaggc ctgggaatcc acatgaggcc cctggccatc      240

tggcttttca tcttcaacgt ctctcaacag atggggggct tctacctgtg ccagccgggg      300

cccccctctg agaaggcctg gcagcctggc tggacagtca atgtggaggg cagcggggag      360

ctgttccggt ggaatgtttc ggacctaggt ggcctgggct gtggcctgaa gaacaggtcc      420

tcagagggcc ccagctcccc ttccgggaag ctcatgagcc ccaagctgta tgtgtgggcc      480

aaagaccgcc ctgagatctg ggagggagag cctccgtgtc tcccaccgag ggacagcctg      540

aaccagagcc tcagccagga cctcaccatg gcccctggct ccacactctg gctgtcctgt      600

ggggtacccc ctgactctgt gtccaggggc cccctctcct ggacccatgt gcaccccaag      660

gggcctaagt cattgctgag cctagagctg aaggacgatc gcccggccag agatatgtgg      720

gtaatggaga cgggtctgtt gttgccccgg gccacagctc aagacgctgg aaagtattat      780

tgtcaccgtg gcaacctgac catgtcattc cacctggaga tcactgctcg gccagtacta      840

tggcactggc tgctgaggac tggtggctgg aaggtctcag ctgtgacttt ggcttatctg      900

atcttctgcc tgtgttccct tgtgggcatt cttcatctt                             939


<210>  34
<211>  313
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<223>  CD19

<400>  34

Met Pro Pro Pro Arg Leu Leu Phe Phe Leu Leu Phe Leu Thr Pro Met 
1               5                   10                  15      


Glu Val Arg Pro Glu Glu Pro Leu Val Val Lys Val Glu Glu Gly Asp 
            20                  25                  30          


Asn Ala Val Leu Gln Cys Leu Lys Gly Thr Ser Asp Gly Pro Thr Gln 
        35                  40                  45              


Gln Leu Thr Trp Ser Arg Glu Ser Pro Leu Lys Pro Phe Leu Lys Leu 
    50                  55                  60                  


Ser Leu Gly Leu Pro Gly Leu Gly Ile His Met Arg Pro Leu Ala Ser 
65                  70                  75                  80  


Trp Leu Phe Ile Phe Asn Val Ser Gln Gln Met Gly Gly Phe Tyr Leu 
                85                  90                  95      


Cys Gln Pro Gly Pro Pro Ser Glu Lys Ala Trp Gln Pro Gly Trp Thr 
            100                 105                 110         


Val Asn Val Glu Gly Ser Gly Glu Leu Phe Arg Trp Asn Val Ser Asp 
        115                 120                 125             


Leu Gly Gly Leu Gly Cys Gly Leu Lys Asn Arg Ser Ser Glu Gly Pro 
    130                 135                 140                 


Ser Ser Pro Ser Gly Lys Leu Met Ser Pro Lys Leu Tyr Val Trp Ala 
145                 150                 155                 160 


Lys Asp Arg Pro Glu Ile Trp Glu Gly Glu Pro Pro Cys Val Pro Pro 
                165                 170                 175     


Arg Asp Ser Leu Asn Gln Ser Leu Ser Gln Asp Leu Thr Met Ala Pro 
            180                 185                 190         


Gly Ser Thr Leu Trp Leu Ser Cys Gly Val Pro Pro Asp Ser Val Ser 
        195                 200                 205             


Arg Gly Pro Leu Ser Trp Thr His Val His Pro Lys Gly Pro Lys Ser 
    210                 215                 220                 


Leu Leu Ser Leu Glu Leu Lys Asp Asp Arg Pro Ala Arg Asp Met Trp 
225                 230                 235                 240 


Val Met Glu Thr Gly Leu Leu Leu Pro Arg Ala Thr Ala Gln Asp Ala 
                245                 250                 255     


Gly Lys Tyr Tyr Cys His Arg Gly Asn Leu Thr Met Ser Phe His Leu 
            260                 265                 270         


Glu Ile Thr Ala Arg Pro Val Leu Trp His Trp Leu Leu Arg Thr Gly 
        275                 280                 285             


Gly Trp Lys Val Ser Ala Val Thr Leu Ala Tyr Leu Ile Phe Cys Leu 
    290                 295                 300                 


Cys Ser Leu Val Gly Ile Leu His Leu 
305                 310             


<210>  35
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide


<220>
<221>  MISC_FEATURE
<223>  linker

<400>  35

Ala Gly Gly Ala Ala Gly 
1               5       


<210>  36
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide


<220>
<221>  misc_feature
<223>  linker

<400>  36
gccggcgggg ctgcaggg                                                     18


<210>  37
<211>  639
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide


<220>
<221>  misc_feature
<223>  TMPK variant

<400>  37
atggcggccc ggcgcggggc tctcatagtg ctggagggcg tggaccgcgc cgggaagagc       60

acgcagagcc gcaagctggt ggaagcgctg tgcgccgcgg gccaccgcgc cgaactgctc      120

cggttcccgg aaagatcaac tgaaatcggc aaacttctga gttcctactt gcaaaagaaa      180

agtgacgtgg aggatcactc ggtgcacctg cttttttctg caaatcgctg ggaacaagtg      240

ccgttaatta aggaaaagtt gagccagggc gtgaccctcg tcgtggacag atacgcattt      300

tctggtgtgg cctacacagg tgccaaggag aatttttccc tagactggtg taaacagcca      360

gacgtgggcc ttcccaaacc cgacctggtc ctgttcctcc agttacagct ggcggatgct      420

gccaagcggg gagcgtttgg ccatgagcgc tatgagaacg gggctttcca ggagcgggcg      480

ctccggtgtt tccaccagct catgaaagac acgactttga actggaagat ggtggatgct      540

tccaaaagca tcgaagctgt ccatgaggac atccgcgtgc tctctgagga cgccatcgcc      600

actgccacag agaagccgct gggggagcta tggaagtga                             639


<210>  38
<211>  939
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide


<220>
<221>  misc_feature
<223>  truncated CD19

<400>  38
atgccacctc ctcgcctcct cttcttcctc ctcttcctca cccccatgga agtcaggccc       60

gaggaacctc tagtggtgaa ggtggaagag ggagataacg ctgtgctgca gtgcctcaag      120

gggacctcag atggccccac tcagcagctg acctggtctc gggagtcccc gcttaaaccc      180

ttcttaaaac tcagcctggg gctgccaggc ctgggaatcc acatgaggcc cctggcatcc      240

tggcttttca tcttcaacgt ctctcaacag atggggggct tctacctgtg ccagccgggg      300

cccccctctg agaaggcctg gcagcctggc tggacagtca atgtggaggg cagcggggag      360

ctgttccggt ggaatgtttc ggacctaggt ggcctgggct gtggcctgaa gaacaggtcc      420

tcagagggcc ccagctcccc ttccgggaag ctcatgagcc ccaagctgta tgtgtgggcc      480

aaagaccgcc ctgagatctg ggagggagag cctccgtgtg tcccaccgag ggacagcctg      540

aaccagagcc tcagccagga cctcaccatg gcccctggct ccacactctg gctgtcctgt      600

ggggtacccc ctgactctgt gtccaggggc cccctctcct ggacccatgt gcaccccaag      660

gggcctaagt cattgctgag cctagagctg aaggacgatc gcccggccag agatatgtgg      720

gtaatggaga cgggtctgtt gttgccccgg gccacagctc aagacgctgg aaagtattat      780

tgtcaccgtg gcaacctgac catgtcattc cacctggaga tcactgctcg gccagtacta      840

tggcactggc tgctgaggac tggtggctgg aaggtctcag ctgtgacttt ggcttatctg      900

atcttctgcc tgtgttccct tgtgggcatt cttcatctt                             939


<210>  39
<211>  212
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide


<220>
<221>  MISC_FEATURE
<223>  TMPK variant

<400>  39

Met Ala Ala Arg Arg Gly Ala Leu Ile Val Leu Glu Gly Val Asp Arg 
1               5                   10                  15      


Ala Gly Lys Ser Thr Gln Ser Arg Lys Leu Val Glu Ala Leu Cys Ala 
            20                  25                  30          


Ala Gly His Arg Ala Glu Leu Leu Arg Phe Pro Glu Arg Ser Thr Glu 
        35                  40                  45              


Ile Gly Lys Leu Leu Ser Ser Tyr Leu Gln Lys Lys Ser Asp Val Glu 
    50                  55                  60                  


Asp His Ser Val His Leu Leu Phe Ser Ala Asn Arg Trp Glu Gln Val 
65                  70                  75                  80  


Pro Leu Ile Lys Glu Lys Leu Ser Gln Gly Val Thr Leu Val Val Asp 
                85                  90                  95      


Arg Tyr Ala Phe Ser Gly Val Ala Tyr Thr Gly Ala Lys Glu Asn Phe 
            100                 105                 110         


Ser Leu Asp Trp Cys Lys Gln Pro Asp Val Gly Leu Pro Lys Pro Asp 
        115                 120                 125             


Leu Val Leu Phe Leu Gln Leu Gln Leu Ala Asp Ala Ala Lys Arg Gly 
    130                 135                 140                 


Ala Phe Gly His Glu Arg Tyr Glu Asn Gly Ala Phe Gln Glu Arg Ala 
145                 150                 155                 160 


Leu Arg Cys Phe His Gln Leu Met Lys Asp Thr Thr Leu Asn Trp Lys 
                165                 170                 175     


Met Val Asp Ala Ser Lys Ser Ile Glu Ala Val His Glu Asp Ile Arg 
            180                 185                 190         


Val Leu Ser Glu Asp Ala Ile Ala Thr Ala Thr Glu Lys Pro Leu Gly 
        195                 200                 205             


Glu Leu Trp Lys 
    210         


<210>  40
<211>  313
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide


<220>
<221>  MISC_FEATURE
<223>  truncated CD19

<400>  40

Met Pro Pro Pro Arg Leu Leu Phe Phe Leu Leu Phe Leu Thr Pro Met 
1               5                   10                  15      


Glu Val Arg Pro Glu Glu Pro Leu Val Val Lys Val Glu Glu Gly Asp 
            20                  25                  30          


Asn Ala Val Leu Gln Cys Leu Lys Gly Thr Ser Asp Gly Pro Thr Gln 
        35                  40                  45              


Gln Leu Thr Trp Ser Arg Glu Ser Pro Leu Lys Pro Phe Leu Lys Leu 
    50                  55                  60                  


Ser Leu Gly Leu Pro Gly Leu Gly Ile His Met Arg Pro Leu Ala Ser 
65                  70                  75                  80  


Trp Leu Phe Ile Phe Asn Val Ser Gln Gln Met Gly Gly Phe Tyr Leu 
                85                  90                  95      


Cys Gln Pro Gly Pro Pro Ser Glu Lys Ala Trp Gln Pro Gly Trp Thr 
            100                 105                 110         


Val Asn Val Glu Gly Ser Gly Glu Leu Phe Arg Trp Asn Val Ser Asp 
        115                 120                 125             


Leu Gly Gly Leu Gly Cys Gly Leu Lys Asn Arg Ser Ser Glu Gly Pro 
    130                 135                 140                 


Ser Ser Pro Ser Gly Lys Leu Met Ser Pro Lys Leu Tyr Val Trp Ala 
145                 150                 155                 160 


Lys Asp Arg Pro Glu Ile Trp Glu Gly Glu Pro Pro Cys Val Pro Pro 
                165                 170                 175     


Arg Asp Ser Leu Asn Gln Ser Leu Ser Gln Asp Leu Thr Met Ala Pro 
            180                 185                 190         


Gly Ser Thr Leu Trp Leu Ser Cys Gly Val Pro Pro Asp Ser Val Ser 
        195                 200                 205             


Arg Gly Pro Leu Ser Trp Thr His Val His Pro Lys Gly Pro Lys Ser 
    210                 215                 220                 


Leu Leu Ser Leu Glu Leu Lys Asp Asp Arg Pro Ala Arg Asp Met Trp 
225                 230                 235                 240 


Val Met Glu Thr Gly Leu Leu Leu Pro Arg Ala Thr Ala Gln Asp Ala 
                245                 250                 255     


Gly Lys Tyr Tyr Cys His Arg Gly Asn Leu Thr Met Ser Phe His Leu 
            260                 265                 270         


Glu Ile Thr Ala Arg Pro Val Leu Trp His Trp Leu Leu Arg Thr Gly 
        275                 280                 285             


Gly Trp Lys Val Ser Ala Val Thr Leu Ala Tyr Leu Ile Phe Cys Leu 
    290                 295                 300                 


Cys Ser Leu Val Gly Ile Leu His Leu 
305                 310             


<210>  41
<211>  531
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide


<220>
<221>  MISC_FEATURE
<223>  Truncated CD19-Linker-TmpkF105YR200A

<400>  41

Met Pro Pro Pro Arg Leu Leu Phe Phe Leu Leu Phe Leu Thr Pro Met 
1               5                   10                  15      


Glu Val Arg Pro Glu Glu Pro Leu Val Val Lys Val Glu Glu Gly Asp 
            20                  25                  30          


Asn Ala Val Leu Gln Cys Leu Lys Gly Thr Ser Asp Gly Pro Thr Gln 
        35                  40                  45              


Gln Leu Thr Trp Ser Arg Glu Ser Pro Leu Lys Pro Phe Leu Lys Leu 
    50                  55                  60                  


Ser Leu Gly Leu Pro Gly Leu Gly Ile His Met Arg Pro Leu Ala Ser 
65                  70                  75                  80  


Trp Leu Phe Ile Phe Asn Val Ser Gln Gln Met Gly Gly Phe Tyr Leu 
                85                  90                  95      


Cys Gln Pro Gly Pro Pro Ser Glu Lys Ala Trp Gln Pro Gly Trp Thr 
            100                 105                 110         


Val Asn Val Glu Gly Ser Gly Glu Leu Phe Arg Trp Asn Val Ser Asp 
        115                 120                 125             


Leu Gly Gly Leu Gly Cys Gly Leu Lys Asn Arg Ser Ser Glu Gly Pro 
    130                 135                 140                 


Ser Ser Pro Ser Gly Lys Leu Met Ser Pro Lys Leu Tyr Val Trp Ala 
145                 150                 155                 160 


Lys Asp Arg Pro Glu Ile Trp Glu Gly Glu Pro Pro Cys Val Pro Pro 
                165                 170                 175     


Arg Asp Ser Leu Asn Gln Ser Leu Ser Gln Asp Leu Thr Met Ala Pro 
            180                 185                 190         


Gly Ser Thr Leu Trp Leu Ser Cys Gly Val Pro Pro Asp Ser Val Ser 
        195                 200                 205             


Arg Gly Pro Leu Ser Trp Thr His Val His Pro Lys Gly Pro Lys Ser 
    210                 215                 220                 


Leu Leu Ser Leu Glu Leu Lys Asp Asp Arg Pro Ala Arg Asp Met Trp 
225                 230                 235                 240 


Val Met Glu Thr Gly Leu Leu Leu Pro Arg Ala Thr Ala Gln Asp Ala 
                245                 250                 255     


Gly Lys Tyr Tyr Cys His Arg Gly Asn Leu Thr Met Ser Phe His Leu 
            260                 265                 270         


Glu Ile Thr Ala Arg Pro Val Leu Trp His Trp Leu Leu Arg Thr Gly 
        275                 280                 285             


Gly Trp Lys Val Ser Ala Val Thr Leu Ala Tyr Leu Ile Phe Cys Leu 
    290                 295                 300                 


Cys Ser Leu Val Gly Ile Leu His Leu Ala Gly Gly Ala Ala Gly Met 
305                 310                 315                 320 


Ala Ala Arg Arg Gly Ala Leu Ile Val Leu Glu Gly Val Asp Arg Ala 
                325                 330                 335     


Gly Lys Ser Thr Gln Ser Arg Lys Leu Val Glu Ala Leu Cys Ala Ala 
            340                 345                 350         


Gly His Arg Ala Glu Leu Leu Arg Phe Pro Glu Arg Ser Thr Glu Ile 
        355                 360                 365             


Gly Lys Leu Leu Ser Ser Tyr Leu Gln Lys Lys Ser Asp Val Glu Asp 
    370                 375                 380                 


His Ser Val His Leu Leu Phe Ser Ala Asn Arg Trp Glu Gln Val Pro 
385                 390                 395                 400 


Leu Ile Lys Glu Lys Leu Ser Gln Gly Val Thr Leu Val Val Asp Arg 
                405                 410                 415     


Tyr Ala Phe Ser Gly Val Ala Tyr Thr Gly Ala Lys Glu Asn Phe Ser 
            420                 425                 430         


Leu Asp Trp Cys Lys Gln Pro Asp Val Gly Leu Pro Lys Pro Asp Leu 
        435                 440                 445             


Val Leu Phe Leu Gln Leu Gln Leu Ala Asp Ala Ala Lys Arg Gly Ala 
    450                 455                 460                 


Phe Gly His Glu Arg Tyr Glu Asn Gly Ala Phe Gln Glu Arg Ala Leu 
465                 470                 475                 480 


Arg Cys Phe His Gln Leu Met Lys Asp Thr Thr Leu Asn Trp Lys Met 
                485                 490                 495     


Val Asp Ala Ser Lys Ser Ile Glu Ala Val His Glu Asp Ile Arg Val 
            500                 505                 510         


Leu Ser Glu Asp Ala Ile Ala Thr Ala Thr Glu Lys Pro Leu Gly Glu 
        515                 520                 525             


Leu Trp Lys 
    530     


<210>  42
<211>  1596
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide


<220>
<221>  misc_feature
<223>  Truncated CD19-Linker-TmpkF105YR200A

<400>  42
atgccacctc ctcgcctcct cttcttcctc ctcttcctca cccccatgga agtcaggccc       60

gaggaacctc tagtggtgaa ggtggaagag ggagataacg ctgtgctgca gtgcctcaag      120

gggacctcag atggccccac tcagcagctg acctggtctc gggagtcccc gcttaaaccc      180

ttcttaaaac tcagcctggg gctgccaggc ctgggaatcc acatgaggcc cctggcatcc      240

tggcttttca tcttcaacgt ctctcaacag atggggggct tctacctgtg ccagccgggg      300

cccccctctg agaaggcctg gcagcctggc tggacagtca atgtggaggg cagcggggag      360

ctgttccggt ggaatgtttc ggacctaggt ggcctgggct gtggcctgaa gaacaggtcc      420

tcagagggcc ccagctcccc ttccgggaag ctcatgagcc ccaagctgta tgtgtgggcc      480

aaagaccgcc ctgagatctg ggagggagag cctccgtgtg tcccaccgag ggacagcctg      540

aaccagagcc tcagccagga cctcaccatg gcccctggct ccacactctg gctgtcctgt      600

ggggtacccc ctgactctgt gtccaggggc cccctctcct ggacccatgt gcaccccaag      660

gggcctaagt cattgctgag cctagagctg aaggacgatc gcccggccag agatatgtgg      720

gtaatggaga cgggtctgtt gttgccccgg gccacagctc aagacgctgg aaagtattat      780

tgtcaccgtg gcaacctgac catgtcattc cacctggaga tcactgctcg gccagtacta      840

tggcactggc tgctgaggac tggtggctgg aaggtctcag ctgtgacttt ggcttatctg      900

atcttctgcc tgtgttccct tgtgggcatt cttcatcttg ccggcggggc tgcagggatg      960

gcggcccggc gcggggctct catagtgctg gagggcgtgg accgcgccgg gaagagcacg     1020

cagagccgca agctggtgga agcgctgtgc gccgcgggcc accgcgccga actgctccgg     1080

ttcccggaaa gatcaactga aatcggcaaa cttctgagtt cctacttgca aaagaaaagt     1140

gacgtggagg atcactcggt gcacctgctt ttttctgcaa atcgctggga acaagtgccg     1200

ttaattaagg aaaagttgag ccagggcgtg accctcgtcg tggacagata cgcattttct     1260

ggtgtggcct acacaggtgc caaggagaat ttttccctag actggtgtaa acagccagac     1320

gtgggccttc ccaaacccga cctggtcctg ttcctccagt tacagctggc ggatgctgcc     1380

aagcggggag cgtttggcca tgagcgctat gagaacgggg ctttccagga gcgggcgctc     1440

cggtgtttcc accagctcat gaaagacacg actttgaact ggaagatggt ggatgcttcc     1500

aaaagcatcg aagctgtcca tgaggacatc cgcgtgctct ctgaggacgc catcgccact     1560

gccacagaga agccgctggg ggagctatgg aagtga                               1596


<210>  43
<211>  1596
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide


<220>
<221>  misc_feature
<223>  CD19deltaTmpkF105YR200A Fusion Polynucleotide

<220>
<221>  misc_feature
<222>  (1)..(939)
<223>  CD19delta

<220>
<221>  misc_feature
<222>  (940)..(957)
<223>  linker

<220>
<221>  misc_feature
<222>  (958)..(1596)
<223>  TmpkF105YR200A

<400>  43
atgccacctc ctcgcctcct cttcttcctc ctcttcctca cccccatgga agtcaggccc       60

gaggaacctc tagtggtgaa ggtggaagag ggagataacg ctgtgctgca gtgcctcaag      120

gggacctcag atggccccac tcagcagctg acctggtctc gggagtcccc gcttaaaccc      180

ttcttaaaac tcagcctggg gctgccaggc ctgggaatcc acatgaggcc cctggcatcc      240

tggcttttca tcttcaacgt ctctcaacag atggggggct tctacctgtg ccagccgggg      300

cccccctctg agaaggcctg gcagcctggc tggacagtca atgtggaggg cagcggggag      360

ctgttccggt ggaatgtttc ggacctaggt ggcctgggct gtggcctgaa gaacaggtcc      420

tcagagggcc ccagctcccc ttccgggaag ctcatgagcc ccaagctgta tgtgtgggcc      480

aaagaccgcc ctgagatctg ggagggagag cctccgtgtg tcccaccgag ggacagcctg      540

aaccagagcc tcagccagga cctcaccatg gcccctggct ccacactctg gctgtcctgt      600

ggggtacccc ctgactctgt gtccaggggc cccctctcct ggacccatgt gcaccccaag      660

gggcctaagt cattgctgag cctagagctg aaggacgatc gcccggccag agatatgtgg      720

gtaatggaga cgggtctgtt gttgccccgg gccacagctc aagacgctgg aaagtattat      780

tgtcaccgtg gcaacctgac catgtcattc cacctggaga tcactgctcg gccagtacta      840

tggcactggc tgctgaggac tggtggctgg aaggtctcag ctgtgacttt ggcttatctg      900

atcttctgcc tgtgttccct tgtgggcatt cttcatcttg ccggcggggc tgcagggatg      960

gcggcccggc gcggggctct catagtgctg gagggcgtgg accgcgccgg gaagagcacg     1020

cagagccgca agctggtgga agcgctgtgc gccgcgggcc accgcgccga actgctccgg     1080

ttcccggaaa gatcaactga aatcggcaaa cttctgagtt cctacttgca aaagaaaagt     1140

gacgtggagg atcactcggt gcacctgctt ttttctgcaa atcgctggga acaagtgccg     1200

ttaattaagg aaaagttgag ccagggcgtg accctcgtcg tggacagata cgcattttct     1260

ggtgtggcct acacaggtgc caaggagaat ttttccctag actggtgtaa acagccagac     1320

gtgggccttc ccaaacccga cctggtcctg ttcctccagt tacagctggc ggatgctgcc     1380

aagcggggag cgtttggcca tgagcgctat gagaacgggg ctttccagga gcgggcgctc     1440

cggtgtttcc accagctcat gaaagacacg actttgaact ggaagatggt ggatgcttcc     1500

aaaagcatcg aagctgtcca tgaggacatc cgcgtgctct ctgaggacgc catcgccact     1560

gccacagaga agccgctggg ggagctatgg aagtga                               1596


<210>  44
<211>  531
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide


<220>
<221>  MISC_FEATURE
<223>  CD19deltaTmpkF105YR200A Fusion Polypeptide

<220>
<221>  MISC_FEATURE
<222>  (1)..(313)
<223>  CD19delta

<220>
<221>  MISC_FEATURE
<222>  (314)..(319)
<223>  Linker

<220>
<221>  MISC_FEATURE
<222>  (320)..(531)
<223>  TmpkF105YR200A

<400>  44

Met Pro Pro Pro Arg Leu Leu Phe Phe Leu Leu Phe Leu Thr Pro Met 
1               5                   10                  15      


Glu Val Arg Pro Glu Glu Pro Leu Val Val Lys Val Glu Glu Gly Asp 
            20                  25                  30          


Asn Ala Val Leu Gln Cys Leu Lys Gly Thr Ser Asp Gly Pro Thr Gln 
        35                  40                  45              


Gln Leu Thr Trp Ser Arg Glu Ser Pro Leu Lys Pro Phe Leu Lys Leu 
    50                  55                  60                  


Ser Leu Gly Leu Pro Gly Leu Gly Ile His Met Arg Pro Leu Ala Ser 
65                  70                  75                  80  


Trp Leu Phe Ile Phe Asn Val Ser Gln Gln Met Gly Gly Phe Tyr Leu 
                85                  90                  95      


Cys Gln Pro Gly Pro Pro Ser Glu Lys Ala Trp Gln Pro Gly Trp Thr 
            100                 105                 110         


Val Asn Val Glu Gly Ser Gly Glu Leu Phe Arg Trp Asn Val Ser Asp 
        115                 120                 125             


Leu Gly Gly Leu Gly Cys Gly Leu Lys Asn Arg Ser Ser Glu Gly Pro 
    130                 135                 140                 


Ser Ser Pro Ser Gly Lys Leu Met Ser Pro Lys Leu Tyr Val Trp Ala 
145                 150                 155                 160 


Lys Asp Arg Pro Glu Ile Trp Glu Gly Glu Pro Pro Cys Val Pro Pro 
                165                 170                 175     


Arg Asp Ser Leu Asn Gln Ser Leu Ser Gln Asp Leu Thr Met Ala Pro 
            180                 185                 190         


Gly Ser Thr Leu Trp Leu Ser Cys Gly Val Pro Pro Asp Ser Val Ser 
        195                 200                 205             


Arg Gly Pro Leu Ser Trp Thr His Val His Pro Lys Gly Pro Lys Ser 
    210                 215                 220                 


Leu Leu Ser Leu Glu Leu Lys Asp Asp Arg Pro Ala Arg Asp Met Trp 
225                 230                 235                 240 


Val Met Glu Thr Gly Leu Leu Leu Pro Arg Ala Thr Ala Gln Asp Ala 
                245                 250                 255     


Gly Lys Tyr Tyr Cys His Arg Gly Asn Leu Thr Met Ser Phe His Leu 
            260                 265                 270         


Glu Ile Thr Ala Arg Pro Val Leu Trp His Trp Leu Leu Arg Thr Gly 
        275                 280                 285             


Gly Trp Lys Val Ser Ala Val Thr Leu Ala Tyr Leu Ile Phe Cys Leu 
    290                 295                 300                 


Cys Ser Leu Val Gly Ile Leu His Leu Ala Gly Gly Ala Ala Gly Met 
305                 310                 315                 320 


Ala Ala Arg Arg Gly Ala Leu Ile Val Leu Glu Gly Val Asp Arg Ala 
                325                 330                 335     


Gly Lys Ser Thr Gln Ser Arg Lys Leu Val Glu Ala Leu Cys Ala Ala 
            340                 345                 350         


Gly His Arg Ala Glu Leu Leu Arg Phe Pro Glu Arg Ser Thr Glu Ile 
        355                 360                 365             


Gly Lys Leu Leu Ser Ser Tyr Leu Gln Lys Lys Ser Asp Val Glu Asp 
    370                 375                 380                 


His Ser Val His Leu Leu Phe Ser Ala Asn Arg Trp Glu Gln Val Pro 
385                 390                 395                 400 


Leu Ile Lys Glu Lys Leu Ser Gln Gly Val Thr Leu Val Val Asp Arg 
                405                 410                 415     


Tyr Ala Phe Ser Gly Val Ala Tyr Thr Gly Ala Lys Glu Asn Phe Ser 
            420                 425                 430         


Leu Asp Trp Cys Lys Gln Pro Asp Val Gly Leu Pro Lys Pro Asp Leu 
        435                 440                 445             


Val Leu Phe Leu Gln Leu Gln Leu Ala Asp Ala Ala Lys Arg Gly Ala 
    450                 455                 460                 


Phe Gly His Glu Arg Tyr Glu Asn Gly Ala Phe Gln Glu Arg Ala Leu 
465                 470                 475                 480 


Arg Cys Phe His Gln Leu Met Lys Asp Thr Thr Leu Asn Trp Lys Met 
                485                 490                 495     


Val Asp Ala Ser Lys Ser Ile Glu Ala Val His Glu Asp Ile Arg Val 
            500                 505                 510         


Leu Ser Glu Asp Ala Ile Ala Thr Ala Thr Glu Lys Pro Leu Gly Glu 
        515                 520                 525             


Leu Trp Lys 
    530     


<210>  45
<211>  894
<212>  DNA
<213>  Homo sapiens


<220>
<221>  misc_feature
<223>  CD20 - Membrane-spanning 4-domains, subfamily A, member 1 (MS4A1)

<400>  45
atgacaacac ccagaaattc agtaaatggg actttcccgg cagagccaat gaaaggccct       60

attgctatgc aatctggtcc aaaaccactc ttcaggagga tgtcttcact ggtgggcccc      120

acgcaaagct tcttcatgag ggaatctaag actttggggg ctgtccagat tatgaatggg      180

ctcttccaca ttgccctggg gggtcttctg atgatcccag cagggatcta tgcacccatc      240

tgtgtgactg tgtggtaccc tctctgggga ggcattatgt atattatttc cggatcactc      300

ctggcagcaa cggagaaaaa ctccaggaag tgtttggtca aaggaaaaat gataatgaat      360

tcattgagcc tctttgctgc catttctgga atgattcttt caatcatgga catacttaat      420

attaaaattt cccatttttt aaaaatggag agtctgaatt ttattagagc tcacacacca      480

tatattaaca tatacaactg tgaaccagct aatccctctg agaaaaactc cccatctacc      540

caatactgtt acagcataca atctctgttc ttgggcattt tgtcagtgat gctgatcttt      600

gccttcttcc aggaacttgt aatagctggc atcgttgaga atgaatggaa aagaacgtgc      660

tccagaccca aatctaacat agttctcctg tcagcagaag aaaaaaaaga acagactatt      720

gaaataaaag aagaagtggt tgggctaact gaaacatctt cccaaccaaa gaatgaagaa      780

gacattgaaa ttattccaat ccaagaagag gaagaagaag aaacagagac gaactttcca      840

gaacctcccc aagatcagga atcctcacca atagaaaatg acagctctcc ttaa            894


<210>  46
<211>  819
<212>  DNA
<213>  Homo sapiens


<220>
<221>  misc_feature
<223>  CD25 - Interleukin 2 Receptor, alpha (IL2RA)

<400>  46
atggattcat acctgctgat gtggggactg ctcacgttca tcatggtgcc tggctgccag       60

gcagagctct gtgacgatga cccgccagag atcccacacg ccacattcaa agccatggcc      120

tacaaggaag gaaccatgtt gaactgtgaa tgcaagagag gtttccgcag aataaaaagc      180

gggtcactct atatgctctg tacaggaaac tctagccact cgtcctggga caaccaatgt      240

caatgcacaa gctctgccac tcggaacaca acgaaacaag tgacacctca acctgaagaa      300

cagaaagaaa ggaaaaccac agaaatgcaa agtccaatgc agccagtgga ccaagcgagc      360

cttccaggtc actgcaggga acctccacca tgggaaaatg aagccacaga gagaatttat      420

catttcgtgg tggggcagat ggtttattat cagtgcgtcc agggatacag ggctctacac      480

agaggtcctg ctgagagcgt ctgcaaaatg acccacggga agacaaggtg gacccagccc      540

cagctcatat gcacaggtga aatggagacc agtcagtttc caggtgaaga gaagcctcag      600

gcaagccccg aaggccgtcc tgagagtgag acttcctgcc tcgtcacaac aacagatttt      660

caaatacaga cagaaatggc tgcaaccatg gagacgtcca tatttacaac agagtaccag      720

gtagcagtgg ccggctgtgt tttcctgctg atcagcgtcc tcctcctgag tgggctcacc      780

tggcagcgga gacagaggaa gagtagaaga acaatctag                             819


<210>  47
<211>  1284
<212>  DNA
<213>  Homo sapiens


<220>
<221>  misc_feature
<223>  LNGFR - Nerve Growth Factor Receptor

<400>  47
atgggggcag gtgccaccgg ccgcgccatg gacgggccgc gcctgctgct gttgctgctt       60

ctgggggtgt cccttggagg tgccaaggag gcatgcccca caggcctgta cacacacagc      120

ggtgagtgct gcaaagcctg caacctgggc gagggtgtgg cccagccttg tggagccaac      180

cagaccgtgt gtgagccctg cctggacagc gtgacgttct ccgacgtggt gagcgcgacc      240

gagccgtgca agccgtgcac cgagtgcgtg gggctccaga gcatgtcggc gccgtgcgtg      300

gaggccgacg acgccgtgtg ccgctgcgcc tacggctact accaggatga gacgactggg      360

cgctgcgagg cgtgccgcgt gtgcgaggcg ggctcgggcc tcgtgttctc ctgccaggac      420

aagcagaaca ccgtgtgcga ggagtgcccc gacggcacgt attccgacga ggccaaccac      480

gtggacccgt gcctgccctg caccgtgtgc gaggacaccg agcgccagct ccgcgagtgc      540

acacgctggg ccgacgccga gtgcgaggag atccctggcc gttggattac acggtccaca      600

cccccagagg gctcggacag cacagccccc agcacccagg agcctgaggc acctccagaa      660

caagacctca tagccagcac ggtggcaggt gtggtgacca cagtgatggg cagctcccag      720

cccgtggtga cccgaggcac caccgacaac ctcatccctg tctattgctc catcctggct      780

gctgtggttg tgggccttgt ggcctacata gccttcaaga ggtggaacag ctgcaagcag      840

aacaagcaag gagccaacag ccggccagtg aaccagacgc ccccaccaga gggagaaaaa      900

ctccacagcg acagtggcat ctccgtggac agccagagcc tgcatgacca gcagccccac      960

acgcagacag cctcgggcca ggccctcaag ggtgacggag gcctctacag cagcctgccc     1020

ccagccaagc gggaggaggt ggagaagctt ctcaacggct ctgcggggga cacctggcgg     1080

cacctggcgg gcgagctggg ctaccagccc gagcacatag actcctttac ccatgaggcc     1140

tgccccgttc gcgccctgct tgcaagctgg gccacccagg acagcgccac actggacgcc     1200

ctcctggccg ccctgcgccg catccagcga gccgacctcg tggagagtct gtgcagtgag     1260

tccactgcca catccccggt gtga                                            1284


