                         SEQUENCE LISTING

<110>  MASSACHUSETTS INSTITUTE OF TECHNOLOGY
       UNIVERSITY OF MASSACHUSETTS
       LEONARD, Effendi
       AJIKUMAR, Parayil K
       PRATHER, Kristala Lanett Jones 
       STEPHANOPOULOS, Gregory
       THAYER, Kelly
 
<120>  METHODS FOR MICROBIAL PRODUCTION OF TERPENOIDS

<130>  M0656.70197WO00

<150>  US 12/615,985
<151>  2009-11-10

<160>  146   

<170>  PatentIn version 3.5

<210>  1
<211>  2705
<212>  DNA
<213>  Ginkgo biloba


<220>
<221>  CDS
<222>  (23)..(2644)

<400>  1
atatttgcct aaacctgcac aa atg gct ggg gtg ctc ttt gca aat ctg cct        52
                         Met Ala Gly Val Leu Phe Ala Asn Leu Pro          
                         1               5                   10           

tgc tca ctg caa ctc tct cca aaa gtt ccc ttc cgg caa tcc act aat        100
Cys Ser Leu Gln Leu Ser Pro Lys Val Pro Phe Arg Gln Ser Thr Asn           
                15                  20                  25                

att ctt att cct ttt cac aag aga tcc tca ttt gga ttt aat gca cag        148
Ile Leu Ile Pro Phe His Lys Arg Ser Ser Phe Gly Phe Asn Ala Gln           
            30                  35                  40                    

cac tgc gtc cgt tct cac tta agg ctg aga tgg aat tgt gtc ggg att        196
His Cys Val Arg Ser His Leu Arg Leu Arg Trp Asn Cys Val Gly Ile           
        45                  50                  55                        

cat gcc tca gct gca gag act cgt cca gat cag ctt cca cag gag gaa        244
His Ala Ser Ala Ala Glu Thr Arg Pro Asp Gln Leu Pro Gln Glu Glu           
    60                  65                  70                            

cgc ttt gtg tcg aga ctt aat gcg gat tat cat cca gct gtc tgg aag        292
Arg Phe Val Ser Arg Leu Asn Ala Asp Tyr His Pro Ala Val Trp Lys           
75                  80                  85                  90            

gac gat ttc atc gac tct cta aca tcc cct aat tcc cac gcg aca tcg        340
Asp Asp Phe Ile Asp Ser Leu Thr Ser Pro Asn Ser His Ala Thr Ser           
                95                  100                 105               

aaa tca agc gtc gat gag aca atc aat aaa aga atc cag aca ttg gtg        388
Lys Ser Ser Val Asp Glu Thr Ile Asn Lys Arg Ile Gln Thr Leu Val           
            110                 115                 120                   

aag gaa atc cag tgc atg ttt cag tcc atg ggc gac ggt gaa acg aat        436
Lys Glu Ile Gln Cys Met Phe Gln Ser Met Gly Asp Gly Glu Thr Asn           
        125                 130                 135                       

cca tct gca tat gat aca gct tgg gtg gca aga att ccg tca att gac        484
Pro Ser Ala Tyr Asp Thr Ala Trp Val Ala Arg Ile Pro Ser Ile Asp           
    140                 145                 150                           

ggc tct ggt gca ccc caa ttt ccc caa acg ctt caa tgg att ctg aac        532
Gly Ser Gly Ala Pro Gln Phe Pro Gln Thr Leu Gln Trp Ile Leu Asn           
155                 160                 165                 170           

aat caa ctg cca gat ggc tcg tgg ggt gag gag tgc att ttt ctg gcg        580
Asn Gln Leu Pro Asp Gly Ser Trp Gly Glu Glu Cys Ile Phe Leu Ala           
                175                 180                 185               

tat gac aga gtt tta aac act ctc gcc tgc ctc ctc act ctc aaa ata        628
Tyr Asp Arg Val Leu Asn Thr Leu Ala Cys Leu Leu Thr Leu Lys Ile           
            190                 195                 200                   

tgg aat aag ggc gac att caa gtg cag aaa ggg gtt gag ttt gtg aga        676
Trp Asn Lys Gly Asp Ile Gln Val Gln Lys Gly Val Glu Phe Val Arg           
        205                 210                 215                       

aaa cac atg gaa gaa atg aag gac gaa gct gac aat cac agg cca agt        724
Lys His Met Glu Glu Met Lys Asp Glu Ala Asp Asn His Arg Pro Ser           
    220                 225                 230                           

gga ttc gag gtc gtg ttt cct gca atg tta gat gaa gca aaa agc ttg        772
Gly Phe Glu Val Val Phe Pro Ala Met Leu Asp Glu Ala Lys Ser Leu           
235                 240                 245                 250           

gga ttg gat ctt cct tat cac ctc cct ttc atc tcc caa atc cac caa        820
Gly Leu Asp Leu Pro Tyr His Leu Pro Phe Ile Ser Gln Ile His Gln           
                255                 260                 265               

aag cgc cag aaa aag ctt caa aag att ccc ctc aat gtt ctt cat aac        868
Lys Arg Gln Lys Lys Leu Gln Lys Ile Pro Leu Asn Val Leu His Asn           
            270                 275                 280                   

cat cag acg gcg ttg ctc tac tct ctg gag ggt ttg caa gat gtg gtg        916
His Gln Thr Ala Leu Leu Tyr Ser Leu Glu Gly Leu Gln Asp Val Val           
        285                 290                 295                       

gac tgg caa gag atc aca aat ctt caa tca aga gac gga tca ttt tta        964
Asp Trp Gln Glu Ile Thr Asn Leu Gln Ser Arg Asp Gly Ser Phe Leu           
    300                 305                 310                           

agc tcc cct gca tct act gct tgt gtc ttc atg cac act caa aac aaa       1012
Ser Ser Pro Ala Ser Thr Ala Cys Val Phe Met His Thr Gln Asn Lys           
315                 320                 325                 330           

cga tgc ctc cac ttt ctc aac ttc gtg ctc agc aaa ttt ggc gac tac       1060
Arg Cys Leu His Phe Leu Asn Phe Val Leu Ser Lys Phe Gly Asp Tyr           
                335                 340                 345               

gtt cct tgc cat tac cca ctt gat cta ttt gaa cgc ctc tgg gct gtc       1108
Val Pro Cys His Tyr Pro Leu Asp Leu Phe Glu Arg Leu Trp Ala Val           
            350                 355                 360                   

gat aca gtt gaa cgc ttg gga atc gat cgc tat ttc aag aaa gaa atc       1156
Asp Thr Val Glu Arg Leu Gly Ile Asp Arg Tyr Phe Lys Lys Glu Ile           
        365                 370                 375                       

aaa gaa tct ctg gat tac gtt tat agg tac tgg gac gcc gaa aga ggc       1204
Lys Glu Ser Leu Asp Tyr Val Tyr Arg Tyr Trp Asp Ala Glu Arg Gly           
    380                 385                 390                           

gtg gga tgg gca aga tgc aat cct att cct gat gtc gat gac act gcc       1252
Val Gly Trp Ala Arg Cys Asn Pro Ile Pro Asp Val Asp Asp Thr Ala           
395                 400                 405                 410           

atg ggt ctt aga atc ctg aga ctt cat gga tac aat gta tct tca gat       1300
Met Gly Leu Arg Ile Leu Arg Leu His Gly Tyr Asn Val Ser Ser Asp           
                415                 420                 425               

gtt ctg gag aat ttc aga gac gag aaa gga gac ttc ttt tgc ttt gcc       1348
Val Leu Glu Asn Phe Arg Asp Glu Lys Gly Asp Phe Phe Cys Phe Ala           
            430                 435                 440                   

ggt caa acg caa att ggt gtg acc gat aat ctt aac ctt tat aga tgt       1396
Gly Gln Thr Gln Ile Gly Val Thr Asp Asn Leu Asn Leu Tyr Arg Cys           
        445                 450                 455                       

tca caa gta tgt ttt ccg gga gaa aag ata atg gaa gaa gct aag acc       1444
Ser Gln Val Cys Phe Pro Gly Glu Lys Ile Met Glu Glu Ala Lys Thr           
    460                 465                 470                           

ttc act aca aat cat ctc caa aat gct ctt gcc aaa aac aac gca ttt       1492
Phe Thr Thr Asn His Leu Gln Asn Ala Leu Ala Lys Asn Asn Ala Phe           
475                 480                 485                 490           

gat aag tgg gct gtc aag aag gat ctt cct gga gag gtg gag tat gct       1540
Asp Lys Trp Ala Val Lys Lys Asp Leu Pro Gly Glu Val Glu Tyr Ala           
                495                 500                 505               

ata aag tat ccg tgg cat aga agt atg cca aga ttg gag gca aga agt       1588
Ile Lys Tyr Pro Trp His Arg Ser Met Pro Arg Leu Glu Ala Arg Ser           
            510                 515                 520                   

tac ata gag caa ttt gga tca aat gat gtc tgg ctg ggg aag act gtg       1636
Tyr Ile Glu Gln Phe Gly Ser Asn Asp Val Trp Leu Gly Lys Thr Val           
        525                 530                 535                       

tat aag atg cta tat gtg agc aac gaa aaa tat ttg gag ctg gcc aaa       1684
Tyr Lys Met Leu Tyr Val Ser Asn Glu Lys Tyr Leu Glu Leu Ala Lys           
    540                 545                 550                           

ttg gac ttc aat atg gtg cag gcc tta cac caa aag gag act caa cac       1732
Leu Asp Phe Asn Met Val Gln Ala Leu His Gln Lys Glu Thr Gln His           
555                 560                 565                 570           

att gtc agc tgg tgg aga gaa tcg gga ttc aat gat ctt aca ttc acc       1780
Ile Val Ser Trp Trp Arg Glu Ser Gly Phe Asn Asp Leu Thr Phe Thr           
                575                 580                 585               

cgc cag cgg cct gtg gaa atg tat ttc tca gtg gcg gtt agt atg ttt       1828
Arg Gln Arg Pro Val Glu Met Tyr Phe Ser Val Ala Val Ser Met Phe           
            590                 595                 600                   

gag cca gaa ttc gct gct tgt aga att gcc tat gcc aag act tct tgc       1876
Glu Pro Glu Phe Ala Ala Cys Arg Ile Ala Tyr Ala Lys Thr Ser Cys           
        605                 610                 615                       

ctc gca gtt att cta gac gat ctt tac gac acc cac gga tct ctg gat       1924
Leu Ala Val Ile Leu Asp Asp Leu Tyr Asp Thr His Gly Ser Leu Asp           
    620                 625                 630                           

gat ctt aaa ttg ttc tct gaa gcg gtc cga aga tgg gat atc tct gtg       1972
Asp Leu Lys Leu Phe Ser Glu Ala Val Arg Arg Trp Asp Ile Ser Val           
635                 640                 645                 650           

ctg gat agc gtt cgg gat aat cag ttg aaa gtt tgc ttc cta ggg ctg       2020
Leu Asp Ser Val Arg Asp Asn Gln Leu Lys Val Cys Phe Leu Gly Leu           
                655                 660                 665               

tac aac aca gtg aat gga ttt gga aaa gat gga ctc aag gaa caa ggc       2068
Tyr Asn Thr Val Asn Gly Phe Gly Lys Asp Gly Leu Lys Glu Gln Gly           
            670                 675                 680                   

cgt gat gtg ctg ggc tat ctt cga aaa gta tgg gag ggc ttg ctc gca       2116
Arg Asp Val Leu Gly Tyr Leu Arg Lys Val Trp Glu Gly Leu Leu Ala           
        685                 690                 695                       

tcg tat acc aaa gaa gcc gaa tgg tcg gca gca aag tat gtg ccg aca       2164
Ser Tyr Thr Lys Glu Ala Glu Trp Ser Ala Ala Lys Tyr Val Pro Thr           
    700                 705                 710                           

ttc aac gaa tat gtg gaa aat gcc aaa gtg tcc ata gca ctt gcg aca       2212
Phe Asn Glu Tyr Val Glu Asn Ala Lys Val Ser Ile Ala Leu Ala Thr           
715                 720                 725                 730           

gtc gta cta aac tca atc ttt ttc act gga gaa tta ctt cct gat tac       2260
Val Val Leu Asn Ser Ile Phe Phe Thr Gly Glu Leu Leu Pro Asp Tyr           
                735                 740                 745               

att tta cag caa gta gac ctt cgg tcc aaa ttt ctg cat ctt gtg tct       2308
Ile Leu Gln Gln Val Asp Leu Arg Ser Lys Phe Leu His Leu Val Ser           
            750                 755                 760                   

ttg act gga cga cta atc aat gac acc aag act tac cag gcc gag aga       2356
Leu Thr Gly Arg Leu Ile Asn Asp Thr Lys Thr Tyr Gln Ala Glu Arg           
        765                 770                 775                       

aac cgt ggt gaa ttg gtt tcc agc gta cag tgc tac atg agg gaa aat       2404
Asn Arg Gly Glu Leu Val Ser Ser Val Gln Cys Tyr Met Arg Glu Asn           
    780                 785                 790                           

ccg gag tgc aca gag gaa gaa gct cta agt cat gtt tat ggt atc atc       2452
Pro Glu Cys Thr Glu Glu Glu Ala Leu Ser His Val Tyr Gly Ile Ile           
795                 800                 805                 810           

gac aac gca ctg aag gaa ttg aat tgg gag ttg gcc aac cca gcg agc       2500
Asp Asn Ala Leu Lys Glu Leu Asn Trp Glu Leu Ala Asn Pro Ala Ser           
                815                 820                 825               

aat gcc cca ttg tgt gtg aga aga ctg ctg ttc aac act gca aga gtg       2548
Asn Ala Pro Leu Cys Val Arg Arg Leu Leu Phe Asn Thr Ala Arg Val           
            830                 835                 840                   

atg cag ctg ttt tat atg tac aga gat ggc ttt ggt atc tct gac aaa       2596
Met Gln Leu Phe Tyr Met Tyr Arg Asp Gly Phe Gly Ile Ser Asp Lys           
        845                 850                 855                       

gag atg aaa gac cat gtc agc cga act ctt ttc gat cct gtg gcg tag       2644
Glu Met Lys Asp His Val Ser Arg Thr Leu Phe Asp Pro Val Ala               
    860                 865                 870                           

catactgata ttatatataa tattcatatt caatccaaaa aaaaaaaaaa aaaaaaaaaa     2704

a                                                                     2705


<210>  2
<211>  873
<212>  PRT
<213>  Ginkgo biloba

<400>  2

Met Ala Gly Val Leu Phe Ala Asn Leu Pro Cys Ser Leu Gln Leu Ser 
1               5                   10                  15      


Pro Lys Val Pro Phe Arg Gln Ser Thr Asn Ile Leu Ile Pro Phe His 
            20                  25                  30          


Lys Arg Ser Ser Phe Gly Phe Asn Ala Gln His Cys Val Arg Ser His 
        35                  40                  45              


Leu Arg Leu Arg Trp Asn Cys Val Gly Ile His Ala Ser Ala Ala Glu 
    50                  55                  60                  


Thr Arg Pro Asp Gln Leu Pro Gln Glu Glu Arg Phe Val Ser Arg Leu 
65                  70                  75                  80  


Asn Ala Asp Tyr His Pro Ala Val Trp Lys Asp Asp Phe Ile Asp Ser 
                85                  90                  95      


Leu Thr Ser Pro Asn Ser His Ala Thr Ser Lys Ser Ser Val Asp Glu 
            100                 105                 110         


Thr Ile Asn Lys Arg Ile Gln Thr Leu Val Lys Glu Ile Gln Cys Met 
        115                 120                 125             


Phe Gln Ser Met Gly Asp Gly Glu Thr Asn Pro Ser Ala Tyr Asp Thr 
    130                 135                 140                 


Ala Trp Val Ala Arg Ile Pro Ser Ile Asp Gly Ser Gly Ala Pro Gln 
145                 150                 155                 160 


Phe Pro Gln Thr Leu Gln Trp Ile Leu Asn Asn Gln Leu Pro Asp Gly 
                165                 170                 175     


Ser Trp Gly Glu Glu Cys Ile Phe Leu Ala Tyr Asp Arg Val Leu Asn 
            180                 185                 190         


Thr Leu Ala Cys Leu Leu Thr Leu Lys Ile Trp Asn Lys Gly Asp Ile 
        195                 200                 205             


Gln Val Gln Lys Gly Val Glu Phe Val Arg Lys His Met Glu Glu Met 
    210                 215                 220                 


Lys Asp Glu Ala Asp Asn His Arg Pro Ser Gly Phe Glu Val Val Phe 
225                 230                 235                 240 


Pro Ala Met Leu Asp Glu Ala Lys Ser Leu Gly Leu Asp Leu Pro Tyr 
                245                 250                 255     


His Leu Pro Phe Ile Ser Gln Ile His Gln Lys Arg Gln Lys Lys Leu 
            260                 265                 270         


Gln Lys Ile Pro Leu Asn Val Leu His Asn His Gln Thr Ala Leu Leu 
        275                 280                 285             


Tyr Ser Leu Glu Gly Leu Gln Asp Val Val Asp Trp Gln Glu Ile Thr 
    290                 295                 300                 


Asn Leu Gln Ser Arg Asp Gly Ser Phe Leu Ser Ser Pro Ala Ser Thr 
305                 310                 315                 320 


Ala Cys Val Phe Met His Thr Gln Asn Lys Arg Cys Leu His Phe Leu 
                325                 330                 335     


Asn Phe Val Leu Ser Lys Phe Gly Asp Tyr Val Pro Cys His Tyr Pro 
            340                 345                 350         


Leu Asp Leu Phe Glu Arg Leu Trp Ala Val Asp Thr Val Glu Arg Leu 
        355                 360                 365             


Gly Ile Asp Arg Tyr Phe Lys Lys Glu Ile Lys Glu Ser Leu Asp Tyr 
    370                 375                 380                 


Val Tyr Arg Tyr Trp Asp Ala Glu Arg Gly Val Gly Trp Ala Arg Cys 
385                 390                 395                 400 


Asn Pro Ile Pro Asp Val Asp Asp Thr Ala Met Gly Leu Arg Ile Leu 
                405                 410                 415     


Arg Leu His Gly Tyr Asn Val Ser Ser Asp Val Leu Glu Asn Phe Arg 
            420                 425                 430         


Asp Glu Lys Gly Asp Phe Phe Cys Phe Ala Gly Gln Thr Gln Ile Gly 
        435                 440                 445             


Val Thr Asp Asn Leu Asn Leu Tyr Arg Cys Ser Gln Val Cys Phe Pro 
    450                 455                 460                 


Gly Glu Lys Ile Met Glu Glu Ala Lys Thr Phe Thr Thr Asn His Leu 
465                 470                 475                 480 


Gln Asn Ala Leu Ala Lys Asn Asn Ala Phe Asp Lys Trp Ala Val Lys 
                485                 490                 495     


Lys Asp Leu Pro Gly Glu Val Glu Tyr Ala Ile Lys Tyr Pro Trp His 
            500                 505                 510         


Arg Ser Met Pro Arg Leu Glu Ala Arg Ser Tyr Ile Glu Gln Phe Gly 
        515                 520                 525             


Ser Asn Asp Val Trp Leu Gly Lys Thr Val Tyr Lys Met Leu Tyr Val 
    530                 535                 540                 


Ser Asn Glu Lys Tyr Leu Glu Leu Ala Lys Leu Asp Phe Asn Met Val 
545                 550                 555                 560 


Gln Ala Leu His Gln Lys Glu Thr Gln His Ile Val Ser Trp Trp Arg 
                565                 570                 575     


Glu Ser Gly Phe Asn Asp Leu Thr Phe Thr Arg Gln Arg Pro Val Glu 
            580                 585                 590         


Met Tyr Phe Ser Val Ala Val Ser Met Phe Glu Pro Glu Phe Ala Ala 
        595                 600                 605             


Cys Arg Ile Ala Tyr Ala Lys Thr Ser Cys Leu Ala Val Ile Leu Asp 
    610                 615                 620                 


Asp Leu Tyr Asp Thr His Gly Ser Leu Asp Asp Leu Lys Leu Phe Ser 
625                 630                 635                 640 


Glu Ala Val Arg Arg Trp Asp Ile Ser Val Leu Asp Ser Val Arg Asp 
                645                 650                 655     


Asn Gln Leu Lys Val Cys Phe Leu Gly Leu Tyr Asn Thr Val Asn Gly 
            660                 665                 670         


Phe Gly Lys Asp Gly Leu Lys Glu Gln Gly Arg Asp Val Leu Gly Tyr 
        675                 680                 685             


Leu Arg Lys Val Trp Glu Gly Leu Leu Ala Ser Tyr Thr Lys Glu Ala 
    690                 695                 700                 


Glu Trp Ser Ala Ala Lys Tyr Val Pro Thr Phe Asn Glu Tyr Val Glu 
705                 710                 715                 720 


Asn Ala Lys Val Ser Ile Ala Leu Ala Thr Val Val Leu Asn Ser Ile 
                725                 730                 735     


Phe Phe Thr Gly Glu Leu Leu Pro Asp Tyr Ile Leu Gln Gln Val Asp 
            740                 745                 750         


Leu Arg Ser Lys Phe Leu His Leu Val Ser Leu Thr Gly Arg Leu Ile 
        755                 760                 765             


Asn Asp Thr Lys Thr Tyr Gln Ala Glu Arg Asn Arg Gly Glu Leu Val 
    770                 775                 780                 


Ser Ser Val Gln Cys Tyr Met Arg Glu Asn Pro Glu Cys Thr Glu Glu 
785                 790                 795                 800 


Glu Ala Leu Ser His Val Tyr Gly Ile Ile Asp Asn Ala Leu Lys Glu 
                805                 810                 815     


Leu Asn Trp Glu Leu Ala Asn Pro Ala Ser Asn Ala Pro Leu Cys Val 
            820                 825                 830         


Arg Arg Leu Leu Phe Asn Thr Ala Arg Val Met Gln Leu Phe Tyr Met 
        835                 840                 845             


Tyr Arg Asp Gly Phe Gly Ile Ser Asp Lys Glu Met Lys Asp His Val 
    850                 855                 860                 


Ser Arg Thr Leu Phe Asp Pro Val Ala 
865                 870             


<210>  3
<211>  1889
<212>  DNA
<213>  Taxus canadensis


<220>
<221>  CDS
<222>  (308)..(1489)

<400>  3
ggaagagcgg caatcattct gtcatttaaa ggttttctgc accgaaatcc tttaatttta       60

aggttttctg gaaggtgtgt gtgaaaattt gaagaaaatt aacaagactg taagtgtttt      120

tatatattta tgagctttgg tttacttggg tgttactgaa ttggaacata cgtgcatgtc      180

ggagcaaagc agcatatttg aaatttgtgg gtgttctttg aggtgtgttg cggatataga      240

tttgattgtt cagagttagt gtattttttt tttttgttgg ttagattaat tgggcaagtt      300

atagaga atg gct tac acg gca atg gca gca ggg acc caa agc ttg caa        349
        Met Ala Tyr Thr Ala Met Ala Ala Gly Thr Gln Ser Leu Gln           
        1               5                   10                            

ctc cgc act gtt gct tcc tat caa gaa tgc aat agt atg agg agt tgt        397
Leu Arg Thr Val Ala Ser Tyr Gln Glu Cys Asn Ser Met Arg Ser Cys           
15                  20                  25                  30            

ttt aaa ttg aca cct ttt aaa agt ttt cat gga gtg aat ttc aat gtt        445
Phe Lys Leu Thr Pro Phe Lys Ser Phe His Gly Val Asn Phe Asn Val           
                35                  40                  45                

ccc tca ctg ggt gct gct aat tgt gag att atg ggt cac ctg aaa ctt        493
Pro Ser Leu Gly Ala Ala Asn Cys Glu Ile Met Gly His Leu Lys Leu           
            50                  55                  60                    

ggg tca ttg cca tat aaa caa tgt tcg gtg tca tct aaa tcc aca aaa        541
Gly Ser Leu Pro Tyr Lys Gln Cys Ser Val Ser Ser Lys Ser Thr Lys           
        65                  70                  75                        

aca atg gcc cag ttg gtt gat ttg gct gaa aca gag aag gcg gag gga        589
Thr Met Ala Gln Leu Val Asp Leu Ala Glu Thr Glu Lys Ala Glu Gly           
    80                  85                  90                            

aag gat att gaa ttt gat ttc aac gag tat atg aag tcc aag gct gtg        637
Lys Asp Ile Glu Phe Asp Phe Asn Glu Tyr Met Lys Ser Lys Ala Val           
95                  100                 105                 110           

gca gtg gat gcg gca ctg gat aag gca atc cca ctt gaa tat cct gaa        685
Ala Val Asp Ala Ala Leu Asp Lys Ala Ile Pro Leu Glu Tyr Pro Glu           
                115                 120                 125               

aaa ata cat gaa tca atg agg tat tca ctt cta gca gga ggt aag cgc        733
Lys Ile His Glu Ser Met Arg Tyr Ser Leu Leu Ala Gly Gly Lys Arg           
            130                 135                 140                   

gtc agg cct gct ctg tgc att gca gca tgt gag ctt gta gga ggg agt        781
Val Arg Pro Ala Leu Cys Ile Ala Ala Cys Glu Leu Val Gly Gly Ser           
        145                 150                 155                       

cag gac ctt gcc atg cca act gcc tgt gca atg gag atg att cat acc        829
Gln Asp Leu Ala Met Pro Thr Ala Cys Ala Met Glu Met Ile His Thr           
    160                 165                 170                           

atg tct ctg att cat gat gac ttg ccg tgc atg gat aat gat gat ttc        877
Met Ser Leu Ile His Asp Asp Leu Pro Cys Met Asp Asn Asp Asp Phe           
175                 180                 185                 190           

aga aga ggg aag cca aca aat cac aag gtc ttt gga gag gac act gct        925
Arg Arg Gly Lys Pro Thr Asn His Lys Val Phe Gly Glu Asp Thr Ala           
                195                 200                 205               

gtt ctt gca ggg gac gcc ctg ctt tca ttt gca ttt gag cat att gct        973
Val Leu Ala Gly Asp Ala Leu Leu Ser Phe Ala Phe Glu His Ile Ala           
            210                 215                 220                   

gtg gct aca agc aag act gtg cct agt gat agg act tta agg gtg ata       1021
Val Ala Thr Ser Lys Thr Val Pro Ser Asp Arg Thr Leu Arg Val Ile           
        225                 230                 235                       

tct gaa ttg ggt aag aca ata ggc tct caa ggg ctt gta ggg ggg cag       1069
Ser Glu Leu Gly Lys Thr Ile Gly Ser Gln Gly Leu Val Gly Gly Gln           
    240                 245                 250                           

gtg gtt gat att aca tcc gag ggg gat gct aat gtg gac ctg aaa acc       1117
Val Val Asp Ile Thr Ser Glu Gly Asp Ala Asn Val Asp Leu Lys Thr           
255                 260                 265                 270           

ctg gaa tgg att cat ata cac aag act gct gtg ctc ttg gaa tgt tca       1165
Leu Glu Trp Ile His Ile His Lys Thr Ala Val Leu Leu Glu Cys Ser           
                275                 280                 285               

gtt gtg agt gga ggg atc ctt ggt ggt gct aca gag gac gag att gcg       1213
Val Val Ser Gly Gly Ile Leu Gly Gly Ala Thr Glu Asp Glu Ile Ala           
            290                 295                 300                   

aga att cgg cgg tac gcc cgg tgt gtg ggg ctt ctg ttt cag gtt gtg       1261
Arg Ile Arg Arg Tyr Ala Arg Cys Val Gly Leu Leu Phe Gln Val Val           
        305                 310                 315                       

gat gac ata ctt gat gtc act aaa tct tct gaa gaa ttg gga aag act       1309
Asp Asp Ile Leu Asp Val Thr Lys Ser Ser Glu Glu Leu Gly Lys Thr           
    320                 325                 330                           

gca gga aag gat ttg ctt act gat aag gct act tat ccc aag ttg atg       1357
Ala Gly Lys Asp Leu Leu Thr Asp Lys Ala Thr Tyr Pro Lys Leu Met           
335                 340                 345                 350           

ggc ctg gag aaa gca aaa gaa ttt gcc gct gaa ttg gcg acg aga gcc       1405
Gly Leu Glu Lys Ala Lys Glu Phe Ala Ala Glu Leu Ala Thr Arg Ala           
                355                 360                 365               

aag gaa gag ctg tca tcc ttt gat cag ata aag gct gca cct ttg ttg       1453
Lys Glu Glu Leu Ser Ser Phe Asp Gln Ile Lys Ala Ala Pro Leu Leu           
            370                 375                 380                   

ggt ctt gca gat tac att gca ttc agg caa aac tga gaacaaagct            1499
Gly Leu Ala Asp Tyr Ile Ala Phe Arg Gln Asn                               
        385                 390                                           

gtaaagctat tcttacatat catctgtttt tttttgacat ctgctgaaaa ttagcaaata     1559

actttttcaa gtttgtatct cccctgaatc ataacgattc aggacatgag gtttctggta     1619

ccattgaaaa gggggcgctc attgtagttg ttttttagct aattccaacc tgttttctat     1679

gtttccactt tggatcaatt tgatgtagat tatgtttgta ggggtgacat tgttagactt     1739

gttacatgtc atcaaattgt tttttgcggc cttaacatgg ttttaacttt tcactagcaa     1799

taaggtggcc taaagtgttt atgtaatttt tcaatataga tagatatctt ttaacaaaaa     1859

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa                                      1889


<210>  4
<211>  393
<212>  PRT
<213>  Taxus canadensis

<400>  4

Met Ala Tyr Thr Ala Met Ala Ala Gly Thr Gln Ser Leu Gln Leu Arg 
1               5                   10                  15      


Thr Val Ala Ser Tyr Gln Glu Cys Asn Ser Met Arg Ser Cys Phe Lys 
            20                  25                  30          


Leu Thr Pro Phe Lys Ser Phe His Gly Val Asn Phe Asn Val Pro Ser 
        35                  40                  45              


Leu Gly Ala Ala Asn Cys Glu Ile Met Gly His Leu Lys Leu Gly Ser 
    50                  55                  60                  


Leu Pro Tyr Lys Gln Cys Ser Val Ser Ser Lys Ser Thr Lys Thr Met 
65                  70                  75                  80  


Ala Gln Leu Val Asp Leu Ala Glu Thr Glu Lys Ala Glu Gly Lys Asp 
                85                  90                  95      


Ile Glu Phe Asp Phe Asn Glu Tyr Met Lys Ser Lys Ala Val Ala Val 
            100                 105                 110         


Asp Ala Ala Leu Asp Lys Ala Ile Pro Leu Glu Tyr Pro Glu Lys Ile 
        115                 120                 125             


His Glu Ser Met Arg Tyr Ser Leu Leu Ala Gly Gly Lys Arg Val Arg 
    130                 135                 140                 


Pro Ala Leu Cys Ile Ala Ala Cys Glu Leu Val Gly Gly Ser Gln Asp 
145                 150                 155                 160 


Leu Ala Met Pro Thr Ala Cys Ala Met Glu Met Ile His Thr Met Ser 
                165                 170                 175     


Leu Ile His Asp Asp Leu Pro Cys Met Asp Asn Asp Asp Phe Arg Arg 
            180                 185                 190         


Gly Lys Pro Thr Asn His Lys Val Phe Gly Glu Asp Thr Ala Val Leu 
        195                 200                 205             


Ala Gly Asp Ala Leu Leu Ser Phe Ala Phe Glu His Ile Ala Val Ala 
    210                 215                 220                 


Thr Ser Lys Thr Val Pro Ser Asp Arg Thr Leu Arg Val Ile Ser Glu 
225                 230                 235                 240 


Leu Gly Lys Thr Ile Gly Ser Gln Gly Leu Val Gly Gly Gln Val Val 
                245                 250                 255     


Asp Ile Thr Ser Glu Gly Asp Ala Asn Val Asp Leu Lys Thr Leu Glu 
            260                 265                 270         


Trp Ile His Ile His Lys Thr Ala Val Leu Leu Glu Cys Ser Val Val 
        275                 280                 285             


Ser Gly Gly Ile Leu Gly Gly Ala Thr Glu Asp Glu Ile Ala Arg Ile 
    290                 295                 300                 


Arg Arg Tyr Ala Arg Cys Val Gly Leu Leu Phe Gln Val Val Asp Asp 
305                 310                 315                 320 


Ile Leu Asp Val Thr Lys Ser Ser Glu Glu Leu Gly Lys Thr Ala Gly 
                325                 330                 335     


Lys Asp Leu Leu Thr Asp Lys Ala Thr Tyr Pro Lys Leu Met Gly Leu 
            340                 345                 350         


Glu Lys Ala Lys Glu Phe Ala Ala Glu Leu Ala Thr Arg Ala Lys Glu 
        355                 360                 365             


Glu Leu Ser Ser Phe Asp Gln Ile Lys Ala Ala Pro Leu Leu Gly Leu 
    370                 375                 380                 


Ala Asp Tyr Ile Ala Phe Arg Gln Asn 
385                 390             


<210>  5
<211>  36
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Oligonucleotide

<400>  5
cgtacgcaaa aacctctaac ctggccgtaa tcctgg                                 36


<210>  6
<211>  36
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Oligonucleotide

<400>  6
ccaggattac ggccaggtta gaggtttttg cgtacg                                 36


<210>  7
<211>  37
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Oligonucleotide

<400>  7
gcaaaaacct cttgcttcgc cgtaatcctg gacgatc                                37


<210>  8
<211>  37
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Oligonucleotide

<400>  8
gatcgtccag gattacggcg aagcaagagg tttttgc                                37


<210>  9
<211>  34
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Oligonucleotide

<400>  9
gtaaagtttg ggagggccag ctggcctcct atac                                   34


<210>  10
<211>  34
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Oligonucleotide

<400>  10
gtataggagg ccagctggcc ctcccaaact ttac                                   34


<210>  11
<211>  35
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Oligonucleotide

<400>  11
gtatgtcgag aacgctagtg ttagcatcgc gctgg                                  35


<210>  12
<211>  35
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Oligonucleotide

<400>  12
ccagcgcgat gctaacacta gcgttctcga catac                                  35


<210>  13
<211>  35
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Oligonucleotide

<400>  13
ctaaagttag catctcgctg gcgaccgttg ttctg                                  35


<210>  14
<211>  35
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Oligonucleotide

<400>  14
cagaacaacg gtcgccagcg agatgctaac tttag                                  35


<210>  15
<211>  35
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Oligonucleotide

<400>  15
ctaaagttag catcgcgctg gggaccgttg ttctg                                  35


<210>  16
<211>  35
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Oligonucleotide

<400>  16
cagaacaacg gtccccagcg cgatgctaac tttag                                  35


<210>  17
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Oligonucleotide

<400>  17
catcgcgctg gcgacccttg ttctgaactc                                        30


<210>  18
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Oligonucleotide

<400>  18
gagttcagaa caagggtcgc cagcgcgatg                                        30


<210>  19
<211>  35
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Oligonucleotide

<400>  19
ccggccgtct gattgccgac accaaaacct atcag                                  35


<210>  20
<211>  35
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Oligonucleotide

<400>  20
ctgataggtt ttggtgtcgg caatcagacg gccgg                                  35


<210>  21
<211>  31
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Oligonucleotide

<400>  21
ccaaaaccta tcaggctgca cgtaaccgtg g                                      31


<210>  22
<211>  31
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Oligonucleotide

<400>  22
ccacggttac gtgcagcctg ataggttttg g                                      31


<210>  23
<211>  34
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Oligonucleotide

<400>  23
cgtcgtctgc tgttcgagac cgcgcgtgta atgc                                   34


<210>  24
<211>  34
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Oligonucleotide

<400>  24
gcattacacg cgcggtctcg aacagcagac gacg                                   34


<210>  25
<211>  37
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Oligonucleotide

<400>  25
gtaccgcgat ggcttcacca tcagcgataa agaaatg                                37


<210>  26
<211>  37
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Oligonucleotide

<400>  26
catttcttta tcgctgatgg tgaagccatc gcggtac                                37


<210>  27
<211>  29
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Oligonucleotide

<400>  27
ccgcgatggc ttcggcctca gcgataaag                                         29


<210>  28
<211>  29
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Oligonucleotide

<400>  28
ctttatcgct gaggccgaag ccatcgcgg                                         29


<210>  29
<211>  36
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Oligonucleotide

<400>  29
gtcagcgccc ggttgaagcg tacttttctg ttgcag                                 36


<210>  30
<211>  36
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Oligonucleotide

<400>  30
ctgcaacaga aaagtacgct tcaaccgggc gctgac                                 36


<210>  31
<211>  36
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Oligonucleotide

<400>  31
gtcagcgccc ggttgaatgt tacttttctg ttgcag                                 36


<210>  32
<211>  36
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Oligonucleotide

<400>  32
ctgcaacaga aaagtaacat tcaaccgggc gctgac                                 36


<210>  33
<211>  36
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Oligonucleotide

<400>  33
gtcagcgccc ggttgaagac tacttttctg ttgcag                                 36


<210>  34
<211>  36
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Oligonucleotide

<400>  34
ctgcaacaga aaagtagtct tcaaccgggc gctgac                                 36


<210>  35
<211>  36
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Oligonucleotide

<400>  35
gtcagcgccc ggttgaagag tacttttctg ttgcag                                 36


<210>  36
<211>  36
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Oligonucleotide

<400>  36
ctgcaacaga aaagtactct tcaaccgggc gctgac                                 36


<210>  37
<211>  36
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Oligonucleotide

<400>  37
gtcagcgccc ggttgaattt tacttttctg ttgcag                                 36


<210>  38
<211>  36
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Oligonucleotide

<400>  38
ctgcaacaga aaagtaaaat tcaaccgggc gctgac                                 36


<210>  39
<211>  36
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Oligonucleotide

<400>  39
gtcagcgccc ggttgaaggg tacttttctg ttgcag                                 36


<210>  40
<211>  36
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Oligonucleotide

<400>  40
ctgcaacaga aaagtaccct tcaaccgggc gctgac                                 36


<210>  41
<211>  36
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Oligonucleotide

<400>  41
gtcagcgccc ggttgaacac tacttttctg ttgcag                                 36


<210>  42
<211>  36
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Oligonucleotide

<400>  42
ctgcaacaga aaagtagtgt tcaaccgggc gctgac                                 36


<210>  43
<211>  36
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Oligonucleotide

<400>  43
gtcagcgccc ggttgaaatc tacttttctg ttgcag                                 36


<210>  44
<211>  36
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Oligonucleotide

<400>  44
ctgcaacaga aaagtagatt tcaaccgggc gctgac                                 36


<210>  45
<211>  36
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Oligonucleotide

<400>  45
gtcagcgccc ggttgaaaaa tacttttctg ttgcag                                 36


<210>  46
<211>  36
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Oligonucleotide

<400>  46
ctgcaacaga aaagtatttt tcaaccgggc gctgac                                 36


<210>  47
<211>  36
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Oligonucleotide

<400>  47
gtcagcgccc ggttgaattg tacttttctg ttgcag                                 36


<210>  48
<211>  36
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Oligonucleotide

<400>  48
ctgcaacaga aaagtacaat tcaaccgggc gctgac                                 36


<210>  49
<211>  36
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Oligonucleotide

<400>  49
gtcagcgccc ggttgaaaac tacttttctg ttgcag                                 36


<210>  50
<211>  36
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Oligonucleotide

<400>  50
ctgcaacaga aaagtagttt tcaaccgggc gctgac                                 36


<210>  51
<211>  36
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Oligonucleotide

<400>  51
gtcagcgccc ggttgaacag tacttttctg ttgcag                                 36


<210>  52
<211>  36
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Oligonucleotide

<400>  52
ctgcaacaga aaagtactgt tcaaccgggc gctgac                                 36


<210>  53
<211>  36
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Oligonucleotide

<400>  53
gtcagcgccc ggttgaaccg tacttttctg ttgcag                                 36


<210>  54
<211>  36
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Oligonucleotide

<400>  54
ctgcaacaga aaagtacggt tcaaccgggc gctgac                                 36


<210>  55
<211>  36
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Oligonucleotide

<400>  55
gtcagcgccc ggttgaaagg tacttttctg ttgcag                                 36


<210>  56
<211>  36
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Oligonucleotide

<400>  56
ctgcaacaga aaagtacctt tcaaccgggc gctgac                                 36


<210>  57
<211>  36
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Oligonucleotide

<400>  57
gtcagcgccc ggttgaatcg tacttttctg ttgcag                                 36


<210>  58
<211>  36
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Oligonucleotide

<400>  58
ctgcaacaga aaagtacgat tcaaccgggc gctgac                                 36


<210>  59
<211>  36
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Oligonucleotide

<400>  59
gtcagcgccc ggttgaaacg tacttttctg ttgcag                                 36


<210>  60
<211>  36
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Oligonucleotide

<400>  60
ctgcaacaga aaagtacgtt tcaaccgggc gctgac                                 36


<210>  61
<211>  36
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Oligonucleotide

<400>  61
gtcagcgccc ggttgaagtg tacttttctg ttgcag                                 36


<210>  62
<211>  36
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Oligonucleotide

<400>  62
ctgcaacaga aaagtacact tcaaccgggc gctgac                                 36


<210>  63
<211>  36
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Oligonucleotide

<400>  63
gtcagcgccc ggttgaatgg tacttttctg ttgcag                                 36


<210>  64
<211>  36
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Oligonucleotide

<400>  64
ctgcaacaga aaagtaccat tcaaccgggc gctgac                                 36


<210>  65
<211>  36
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Oligonucleotide

<400>  65
gtcagcgccc ggttgaatat tacttttctg ttgcag                                 36


<210>  66
<211>  36
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Oligonucleotide

<400>  66
ctgcaacaga aaagtaatat tcaaccgggc gctgac                                 36


<210>  67
<211>  27
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Oligonucleotide

<400>  67
cctcttgcct gtgcgtaatc ctggacg                                           27


<210>  68
<211>  27
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Oligonucleotide

<400>  68
cgtccaggat tacgcacagg caagagg                                           27


<210>  69
<211>  27
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Oligonucleotide

<400>  69
cctcttgcct ggacgtaatc ctggacg                                           27


<210>  70
<211>  27
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Oligonucleotide

<400>  70
cgtccaggat tacgtccagg caagagg                                           27


<210>  71
<211>  27
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Oligonucleotide

<400>  71
cctcttgcct ggaagtaatc ctggacg                                           27


<210>  72
<211>  27
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Oligonucleotide

<400>  72
cgtccaggat tacttccagg caagagg                                           27


<210>  73
<211>  27
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Oligonucleotide

<400>  73
cctcttgcct gttcgtaatc ctggacg                                           27


<210>  74
<211>  27
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Oligonucleotide

<400>  74
cgtccaggat tacgaacagg caagagg                                           27


<210>  75
<211>  27
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Oligonucleotide

<400>  75
cctcttgcct gggcgtaatc ctggacg                                           27


<210>  76
<211>  27
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Oligonucleotide

<400>  76
cgtccaggat tacgcccagg caagagg                                           27


<210>  77
<211>  27
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Oligonucleotide

<400>  77
cctcttgcct gcacgtaatc ctggacg                                           27


<210>  78
<211>  27
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Oligonucleotide

<400>  78
cgtccaggat tacgtgcagg caagagg                                           27


<210>  79
<211>  27
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Oligonucleotide

<400>  79
cctcttgcct gatcgtaatc ctggacg                                           27


<210>  80
<211>  27
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Oligonucleotide

<400>  80
cgtccaggat tacgatcagg caagagg                                           27


<210>  81
<211>  27
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Oligonucleotide

<400>  81
cctcttgcct gaaagtaatc ctggacg                                           27


<210>  82
<211>  27
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Oligonucleotide

<400>  82
cgtccaggat tactttcagg caagagg                                           27


<210>  83
<211>  27
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Oligonucleotide

<400>  83
cctcttgcct gctcgtaatc ctggacg                                           27


<210>  84
<211>  27
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Oligonucleotide

<400>  84
cgtccaggat tacgagcagg caagagg                                           27


<210>  85
<211>  27
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Oligonucleotide

<400>  85
cctcttgcct gatggtaatc ctggacg                                           27


<210>  86
<211>  27
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Oligonucleotide

<400>  86
cgtccaggat taccatcagg caagagg                                           27


<210>  87
<211>  27
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Oligonucleotide

<400>  87
cctcttgcct gaacgtaatc ctggacg                                           27


<210>  88
<211>  27
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Oligonucleotide

<400>  88
cgtccaggat tacgttcagg caagagg                                           27


<210>  89
<211>  27
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Oligonucleotide

<400>  89
cctcttgcct gcccgtaatc ctggacg                                           27


<210>  90
<211>  27
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Oligonucleotide

<400>  90
cgtccaggat tacgggcagg caagagg                                           27


<210>  91
<211>  27
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Oligonucleotide

<400>  91
cctcttgcct gcaagtaatc ctggacg                                           27


<210>  92
<211>  27
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Oligonucleotide

<400>  92
cgtccaggat tacttgcagg caagagg                                           27


<210>  93
<211>  27
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Oligonucleotide

<400>  93
cctcttgcct gcgcgtaatc ctggacg                                           27


<210>  94
<211>  27
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Oligonucleotide

<400>  94
cgtccaggat tacgcgcagg caagagg                                           27


<210>  95
<211>  27
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Oligonucleotide

<400>  95
cctcttgcct gtccgtaatc ctggacg                                           27


<210>  96
<211>  27
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Oligonucleotide

<400>  96
cgtccaggat tacggacagg caagagg                                           27


<210>  97
<211>  27
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Oligonucleotide

<400>  97
cctcttgcct gaccgtaatc ctggacg                                           27


<210>  98
<211>  27
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Oligonucleotide

<400>  98
cgtccaggat tacggtcagg caagagg                                           27


<210>  99
<211>  27
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Oligonucleotide

<400>  99
cctcttgcct ggtcgtaatc ctggacg                                           27


<210>  100
<211>  27
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Oligonucleotide

<400>  100
cgtccaggat tacgaccagg caagagg                                           27


<210>  101
<211>  27
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Oligonucleotide

<400>  101
cctcttgcct gtgggtaatc ctggacg                                           27


<210>  102
<211>  27
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Oligonucleotide

<400>  102
cgtccaggat tacccacagg caagagg                                           27


<210>  103
<211>  27
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Oligonucleotide

<400>  103
cctcttgcct gtacgtaatc ctggacg                                           27


<210>  104
<211>  27
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Oligonucleotide

<400>  104
cgtccaggat tacgtacagg caagagg                                           27


<210>  105
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Oligonucleotide

<400>  105
ggcctgctgg cctccgctac caaggaagcg                                        30


<210>  106
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Oligonucleotide

<400>  106
cgcttccttg gtagcggagg ccagcaggcc                                        30


<210>  107
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Oligonucleotide

<400>  107
ggcctgctgg cctcctgtac caaggaagcg                                        30


<210>  108
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Oligonucleotide

<400>  108
cgcttccttg gtacaggagg ccagcaggcc                                        30


<210>  109
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Oligonucleotide

<400>  109
ggcctgctgg cctccgatac caaggaagcg                                        30


<210>  110
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Oligonucleotide

<400>  110
cgcttccttg gtatcggagg ccagcaggcc                                        30


<210>  111
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Oligonucleotide

<400>  111
ggcctgctgg cctccgaaac caaggaagcg                                        30


<210>  112
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Oligonucleotide

<400>  112
cgcttccttg gtttcggagg ccagcaggcc                                        30


<210>  113
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Oligonucleotide

<400>  113
ggcctgctgg cctcctttac caaggaagcg                                        30


<210>  114
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Oligonucleotide

<400>  114
cgcttccttg gtaaaggagg ccagcaggcc                                        30


<210>  115
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Oligonucleotide

<400>  115
ggcctgctgg cctccggtac caaggaagcg                                        30


<210>  116
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Oligonucleotide

<400>  116
cgcttccttg gtaccggagg ccagcaggcc                                        30


<210>  117
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Oligonucleotide

<400>  117
ggcctgctgg cctcccatac caaggaagcg                                        30


<210>  118
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Oligonucleotide

<400>  118
cgcttccttg gtatgggagg ccagcaggcc                                        30


<210>  119
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Oligonucleotide

<400>  119
ggcctgctgg cctccattac caaggaagcg                                        30


<210>  120
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Oligonucleotide

<400>  120
cgcttccttg gtaatggagg ccagcaggcc                                        30


<210>  121
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Oligonucleotide

<400>  121
ggcctgctgg cctccaaaac caaggaagcg                                        30


<210>  122
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Oligonucleotide

<400>  122
cgcttccttg gttttggagg ccagcaggcc                                        30


<210>  123
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Oligonucleotide

<400>  123
ggcctgctgg cctccttaac caaggaagcg                                        30


<210>  124
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Oligonucleotide

<400>  124
cgcttccttg gttaaggagg ccagcaggcc                                        30


<210>  125
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Oligonucleotide

<400>  125
ggcctgctgg cctccatgac caaggaagcg                                        30


<210>  126
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Oligonucleotide

<400>  126
cgcttccttg gtcatggagg ccagcaggcc                                        30


<210>  127
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Oligonucleotide

<400>  127
ggcctgctgg cctccaatac caaggaagcg                                        30


<210>  128
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Oligonucleotide

<400>  128
cgcttccttg gtattggagg ccagcaggcc                                        30


<210>  129
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Oligonucleotide

<400>  129
ggcctgctgg cctcccctac caaggaagcg                                        30


<210>  130
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Oligonucleotide

<400>  130
cgcttccttg gtaggggagg ccagcaggcc                                        30


<210>  131
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Oligonucleotide

<400>  131
ggcctgctgg cctccgaaac caaggaagcg                                        30


<210>  132
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Oligonucleotide

<400>  132
cgcttccttg gtttcggagg ccagcaggcc                                        30


<210>  133
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Oligonucleotide

<400>  133
ggcctgctgg cctcccgtac caaggaagcg                                        30


<210>  134
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Oligonucleotide

<400>  134
cgcttccttg gtacgggagg ccagcaggcc                                        30


<210>  135
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Oligonucleotide

<400>  135
ggcctgctgg cctcctctac caaggaagcg                                        30


<210>  136
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Oligonucleotide

<400>  136
cgcttccttg gtagaggagg ccagcaggcc                                        30


<210>  137
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Oligonucleotide

<400>  137
ggcctgctgg cctccactac caaggaagcg                                        30


<210>  138
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Oligonucleotide

<400>  138
cgcttccttg gtagtggagg ccagcaggcc                                        30


<210>  139
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Oligonucleotide

<400>  139
ggcctgctgg cctccgttac caaggaagcg                                        30


<210>  140
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Oligonucleotide

<400>  140
cgcttccttg gtaacggagg ccagcaggcc                                        30


<210>  141
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Oligonucleotide

<400>  141
ggcctgctgg cctcctggac caaggaagcg                                        30


<210>  142
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Oligonucleotide

<400>  142
cgcttccttg gtccaggagg ccagcaggcc                                        30


<210>  143
<211>  891
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic cDNA


<220>
<221>  CDS
<222>  (1)..(891)

<400>  143
atg ttt gat ttc aat gaa tat atg aaa tcg aaa gca gtt gca gtt gat         48
Met Phe Asp Phe Asn Glu Tyr Met Lys Ser Lys Ala Val Ala Val Asp           
1               5                   10                  15                

gct gcg ctt gac aaa gcg att ccg ctg gaa tac cct gaa aag att cac         96
Ala Ala Leu Asp Lys Ala Ile Pro Leu Glu Tyr Pro Glu Lys Ile His           
            20                  25                  30                    

gaa tcg atg cgc tat agt ctg ctg gct ggt ggc aaa cgc gtg cgc cca        144
Glu Ser Met Arg Tyr Ser Leu Leu Ala Gly Gly Lys Arg Val Arg Pro           
        35                  40                  45                        

gct ctt tgc att gcg gca tgt gag ctg gta ggc ggt tcc cag gat ctg        192
Ala Leu Cys Ile Ala Ala Cys Glu Leu Val Gly Gly Ser Gln Asp Leu           
    50                  55                  60                            

gct atg cca acg gcg tgc gca atg gaa atg atc cat aca atg tcc ctg        240
Ala Met Pro Thr Ala Cys Ala Met Glu Met Ile His Thr Met Ser Leu           
65                  70                  75                  80            

atc cac gat gat ctg ccg tgt atg gat aat gat gac ttc cgc cgt gga        288
Ile His Asp Asp Leu Pro Cys Met Asp Asn Asp Asp Phe Arg Arg Gly           
                85                  90                  95                

aaa ccg act aac cat aaa gta ttt ggc gag gac act gca gtg ttg gca        336
Lys Pro Thr Asn His Lys Val Phe Gly Glu Asp Thr Ala Val Leu Ala           
            100                 105                 110                   

gga gac gcc ctg ttg agc ttt gcc ttt gaa cat att gcc gtc gcg acc        384
Gly Asp Ala Leu Leu Ser Phe Ala Phe Glu His Ile Ala Val Ala Thr           
        115                 120                 125                       

tca aaa aca gtt cct tct gat cgt acc ctg cgc gtc atc agt gag tta        432
Ser Lys Thr Val Pro Ser Asp Arg Thr Leu Arg Val Ile Ser Glu Leu           
    130                 135                 140                           

ggt aag acc att ggc agc cag ggg ctg gta ggc ggc cag gtc gtg gat        480
Gly Lys Thr Ile Gly Ser Gln Gly Leu Val Gly Gly Gln Val Val Asp           
145                 150                 155                 160           

atc acg tct gaa ggt gac gcg aat gtg gat ctt aag acc tta gag tgg        528
Ile Thr Ser Glu Gly Asp Ala Asn Val Asp Leu Lys Thr Leu Glu Trp           
                165                 170                 175               

att cac atc cat aaa acg gcc gtg ctg ctg gaa tgc tcg gtt gtg tcc        576
Ile His Ile His Lys Thr Ala Val Leu Leu Glu Cys Ser Val Val Ser           
            180                 185                 190                   

ggt ggg atc ctg ggg ggc gcc act gag gac gaa atc gcc cgt att cgc        624
Gly Gly Ile Leu Gly Gly Ala Thr Glu Asp Glu Ile Ala Arg Ile Arg           
        195                 200                 205                       

cgt tat gca cgg tgt gtg ggc ctc ttg ttt caa gtc gtg gat gat att        672
Arg Tyr Ala Arg Cys Val Gly Leu Leu Phe Gln Val Val Asp Asp Ile           
    210                 215                 220                           

ctg gat gtg acg aaa tct agt gag gag ctc ggt aaa acc gcg ggc aag        720
Leu Asp Val Thr Lys Ser Ser Glu Glu Leu Gly Lys Thr Ala Gly Lys           
225                 230                 235                 240           

gat ctc ctg acc gac aag gcg acg tac ccg aaa ctg atg ggt ttg gaa        768
Asp Leu Leu Thr Asp Lys Ala Thr Tyr Pro Lys Leu Met Gly Leu Glu           
                245                 250                 255               

aag gct aag gag ttt gct gcc gaa tta gcg acc aga gcc aaa gaa gaa        816
Lys Ala Lys Glu Phe Ala Ala Glu Leu Ala Thr Arg Ala Lys Glu Glu           
            260                 265                 270                   

ctc tct tct ttc gac cag atc aag gta gcg ccc ctt tta ggg ctc gcc        864
Leu Ser Ser Phe Asp Gln Ile Lys Val Ala Pro Leu Leu Gly Leu Ala           
        275                 280                 285                       

gat tac att gcg ttt cgt cag ttg tga                                    891
Asp Tyr Ile Ala Phe Arg Gln Leu                                           
    290                 295                                               


<210>  144
<211>  296
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  144

Met Phe Asp Phe Asn Glu Tyr Met Lys Ser Lys Ala Val Ala Val Asp 
1               5                   10                  15      


Ala Ala Leu Asp Lys Ala Ile Pro Leu Glu Tyr Pro Glu Lys Ile His 
            20                  25                  30          


Glu Ser Met Arg Tyr Ser Leu Leu Ala Gly Gly Lys Arg Val Arg Pro 
        35                  40                  45              


Ala Leu Cys Ile Ala Ala Cys Glu Leu Val Gly Gly Ser Gln Asp Leu 
    50                  55                  60                  


Ala Met Pro Thr Ala Cys Ala Met Glu Met Ile His Thr Met Ser Leu 
65                  70                  75                  80  


Ile His Asp Asp Leu Pro Cys Met Asp Asn Asp Asp Phe Arg Arg Gly 
                85                  90                  95      


Lys Pro Thr Asn His Lys Val Phe Gly Glu Asp Thr Ala Val Leu Ala 
            100                 105                 110         


Gly Asp Ala Leu Leu Ser Phe Ala Phe Glu His Ile Ala Val Ala Thr 
        115                 120                 125             


Ser Lys Thr Val Pro Ser Asp Arg Thr Leu Arg Val Ile Ser Glu Leu 
    130                 135                 140                 


Gly Lys Thr Ile Gly Ser Gln Gly Leu Val Gly Gly Gln Val Val Asp 
145                 150                 155                 160 


Ile Thr Ser Glu Gly Asp Ala Asn Val Asp Leu Lys Thr Leu Glu Trp 
                165                 170                 175     


Ile His Ile His Lys Thr Ala Val Leu Leu Glu Cys Ser Val Val Ser 
            180                 185                 190         


Gly Gly Ile Leu Gly Gly Ala Thr Glu Asp Glu Ile Ala Arg Ile Arg 
        195                 200                 205             


Arg Tyr Ala Arg Cys Val Gly Leu Leu Phe Gln Val Val Asp Asp Ile 
    210                 215                 220                 


Leu Asp Val Thr Lys Ser Ser Glu Glu Leu Gly Lys Thr Ala Gly Lys 
225                 230                 235                 240 


Asp Leu Leu Thr Asp Lys Ala Thr Tyr Pro Lys Leu Met Gly Leu Glu 
                245                 250                 255     


Lys Ala Lys Glu Phe Ala Ala Glu Leu Ala Thr Arg Ala Lys Glu Glu 
            260                 265                 270         


Leu Ser Ser Phe Asp Gln Ile Lys Val Ala Pro Leu Leu Gly Leu Ala 
        275                 280                 285             


Asp Tyr Ile Ala Phe Arg Gln Leu 
    290                 295     


<210>  145
<211>  2505
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic cDNA


<220>
<221>  CDS
<222>  (1)..(2505)

<400>  145
atg gct cag cac tgc gtc cgt tcc cac ctg cgt ctg cgt tgg aat tgc         48
Met Ala Gln His Cys Val Arg Ser His Leu Arg Leu Arg Trp Asn Cys           
1               5                   10                  15                

gtt ggc atc cac gcg tct gct gct gaa act cgt ccg gat cag ctg ccg         96
Val Gly Ile His Ala Ser Ala Ala Glu Thr Arg Pro Asp Gln Leu Pro           
            20                  25                  30                    

cag gaa gaa cgt ttt gtg agc cgt ctg aac gcg gac tac cac ccg gcg        144
Gln Glu Glu Arg Phe Val Ser Arg Leu Asn Ala Asp Tyr His Pro Ala           
        35                  40                  45                        

gtg tgg aaa gat gat ttt atc gat tct ctg act tcc cca aac agc cat        192
Val Trp Lys Asp Asp Phe Ile Asp Ser Leu Thr Ser Pro Asn Ser His           
    50                  55                  60                            

gcg acc tcc aaa agc tcc gtt gat gaa acc atc aac aaa cgc att cag        240
Ala Thr Ser Lys Ser Ser Val Asp Glu Thr Ile Asn Lys Arg Ile Gln           
65                  70                  75                  80            

act ctg gtg aag gag atc cag tgc atg ttc cag tcc atg ggt gat ggt        288
Thr Leu Val Lys Glu Ile Gln Cys Met Phe Gln Ser Met Gly Asp Gly           
                85                  90                  95                

gaa acc aat ccg tct gca tat gac acc gcg tgg gtg gct cgc att ccg        336
Glu Thr Asn Pro Ser Ala Tyr Asp Thr Ala Trp Val Ala Arg Ile Pro           
            100                 105                 110                   

agc att gat ggt tcc ggt gcg ccg cag ttt ccg cag acg ctg caa tgg        384
Ser Ile Asp Gly Ser Gly Ala Pro Gln Phe Pro Gln Thr Leu Gln Trp           
        115                 120                 125                       

atc ctg aac aac cag ctg cct gat ggt agc tgg ggt gaa gag tgc atc        432
Ile Leu Asn Asn Gln Leu Pro Asp Gly Ser Trp Gly Glu Glu Cys Ile           
    130                 135                 140                           

ttc ctg gct tac gat cgc gtt ctg aac acg ctg gct tgt ctg ctg act        480
Phe Leu Ala Tyr Asp Arg Val Leu Asn Thr Leu Ala Cys Leu Leu Thr           
145                 150                 155                 160           

ctg aaa atc tgg aac aag ggt gac atc cag gta caa aaa ggc gtt gag        528
Leu Lys Ile Trp Asn Lys Gly Asp Ile Gln Val Gln Lys Gly Val Glu           
                165                 170                 175               

ttt gtg cgc aaa cac atg gaa gag atg aaa gat gaa gca gac aac cat        576
Phe Val Arg Lys His Met Glu Glu Met Lys Asp Glu Ala Asp Asn His           
            180                 185                 190                   

cgt cca tct ggc ttc gaa gtg gta ttt cca gcg atg ctg gat gag gcg        624
Arg Pro Ser Gly Phe Glu Val Val Phe Pro Ala Met Leu Asp Glu Ala           
        195                 200                 205                       

aaa agc ctg ggc ctg gat ctg ccg tac cac ctg ccg ttc atc agc cag        672
Lys Ser Leu Gly Leu Asp Leu Pro Tyr His Leu Pro Phe Ile Ser Gln           
    210                 215                 220                           

atc cac caa aaa cgt cag aaa aag ctg cag aag atc ccg ctg aac gtc        720
Ile His Gln Lys Arg Gln Lys Lys Leu Gln Lys Ile Pro Leu Asn Val           
225                 230                 235                 240           

ctg cat aac cat caa act gct ctg ctg tac tct ctg gaa ggt ctg caa        768
Leu His Asn His Gln Thr Ala Leu Leu Tyr Ser Leu Glu Gly Leu Gln           
                245                 250                 255               

gat gtt gtg gac tgg cag gaa atc act aac ctg caa agc cgt gac ggt        816
Asp Val Val Asp Trp Gln Glu Ile Thr Asn Leu Gln Ser Arg Asp Gly           
            260                 265                 270                   

agc ttt ctg agc tct ccg gca tct act gct tgt gtt ttt atg cac acc        864
Ser Phe Leu Ser Ser Pro Ala Ser Thr Ala Cys Val Phe Met His Thr           
        275                 280                 285                       

cag aac aaa cgc tgc ctg cat ttc ctg aac ttc gtt ctg tct aag ttc        912
Gln Asn Lys Arg Cys Leu His Phe Leu Asn Phe Val Leu Ser Lys Phe           
    290                 295                 300                           

ggt gat tac gta cct tgc cac tac ccg ctg gac ctg ttc gag cgt ctg        960
Gly Asp Tyr Val Pro Cys His Tyr Pro Leu Asp Leu Phe Glu Arg Leu           
305                 310                 315                 320           

tgg gcg gtt gat acg gtt gag cgt ctg ggc att gac cgt tac ttt aag       1008
Trp Ala Val Asp Thr Val Glu Arg Leu Gly Ile Asp Arg Tyr Phe Lys           
                325                 330                 335               

aaa gag atc aaa gag agc ctg gat tat gtt tac cgc tat tgg gac gcg       1056
Lys Glu Ile Lys Glu Ser Leu Asp Tyr Val Tyr Arg Tyr Trp Asp Ala           
            340                 345                 350                   

gag cgt ggc gta ggt tgg gcg cgc tgt aac cca att ccg gac gtt gac       1104
Glu Arg Gly Val Gly Trp Ala Arg Cys Asn Pro Ile Pro Asp Val Asp           
        355                 360                 365                       

gat acg gct atg ggt ctg cgc atc ctg cgc ctg cac ggt tac aac gta       1152
Asp Thr Ala Met Gly Leu Arg Ile Leu Arg Leu His Gly Tyr Asn Val           
    370                 375                 380                           

agc tct gat gta ctg gag aac ttt cgc gac gaa aaa ggc gat ttc ttc       1200
Ser Ser Asp Val Leu Glu Asn Phe Arg Asp Glu Lys Gly Asp Phe Phe           
385                 390                 395                 400           

tgt ttc gcg ggt cag acc caa atc ggc gtt acc gac aac ctg aac ctg       1248
Cys Phe Ala Gly Gln Thr Gln Ile Gly Val Thr Asp Asn Leu Asn Leu           
                405                 410                 415               

tac cgc tgc tct cag gtt tgc ttc ccg ggt gag aaa atc atg gag gag       1296
Tyr Arg Cys Ser Gln Val Cys Phe Pro Gly Glu Lys Ile Met Glu Glu           
            420                 425                 430                   

gct aaa acg ttc acg acc aac cat ctg cag aat gct ctg gcg aag aat       1344
Ala Lys Thr Phe Thr Thr Asn His Leu Gln Asn Ala Leu Ala Lys Asn           
        435                 440                 445                       

aac gca ttt gac aaa tgg gcg gtt aaa aag gat ctg cca ggt gaa gtc       1392
Asn Ala Phe Asp Lys Trp Ala Val Lys Lys Asp Leu Pro Gly Glu Val           
    450                 455                 460                           

gag tac gca att aag tac ccg tgg cat cgc agc atg ccg cgc ctg gaa       1440
Glu Tyr Ala Ile Lys Tyr Pro Trp His Arg Ser Met Pro Arg Leu Glu           
465                 470                 475                 480           

gcg cgt tct tat atc gaa cag ttc ggt tct aac gac gtc tgg ctg ggc       1488
Ala Arg Ser Tyr Ile Glu Gln Phe Gly Ser Asn Asp Val Trp Leu Gly           
                485                 490                 495               

aaa act gtt tac aaa atg ctg tac gtc tcc aac gaa aaa tac ctg gaa       1536
Lys Thr Val Tyr Lys Met Leu Tyr Val Ser Asn Glu Lys Tyr Leu Glu           
            500                 505                 510                   

ctg gct aaa ctg gat ttc aac atg gta cag gca ctg cac cag aag gag       1584
Leu Ala Lys Leu Asp Phe Asn Met Val Gln Ala Leu His Gln Lys Glu           
        515                 520                 525                       

acg cag cat atc gtt tct tgg tgg cgt gaa agc ggt ttc aac gac ctg       1632
Thr Gln His Ile Val Ser Trp Trp Arg Glu Ser Gly Phe Asn Asp Leu           
    530                 535                 540                           

acc ttt acc cgt cag cgc ccg gtt gaa atg tac ttt tct gtt gca gta       1680
Thr Phe Thr Arg Gln Arg Pro Val Glu Met Tyr Phe Ser Val Ala Val           
545                 550                 555                 560           

agc atg ttc gaa cct gag ttc gct gct tgt cgt atc gcg tac gca aaa       1728
Ser Met Phe Glu Pro Glu Phe Ala Ala Cys Arg Ile Ala Tyr Ala Lys           
                565                 570                 575               

acc tct tgc ctg gcc gta atc ctg gac gat ctg tac gac acg cac ggt       1776
Thr Ser Cys Leu Ala Val Ile Leu Asp Asp Leu Tyr Asp Thr His Gly           
            580                 585                 590                   

tcc ctg gat gac ctg aaa ctg ttc tct gaa gcg gtt cgt cgt tgg gat       1824
Ser Leu Asp Asp Leu Lys Leu Phe Ser Glu Ala Val Arg Arg Trp Asp           
        595                 600                 605                       

atc agc gta ctg gac tct gtg cgc gat aac cag ctg aaa gtg tgc ttt       1872
Ile Ser Val Leu Asp Ser Val Arg Asp Asn Gln Leu Lys Val Cys Phe           
    610                 615                 620                           

ctg ggt ctg tac aac acg gtg aac ggc ttc ggt aag gat ggt ctg aaa       1920
Leu Gly Leu Tyr Asn Thr Val Asn Gly Phe Gly Lys Asp Gly Leu Lys           
625                 630                 635                 640           

gaa cag ggt cgc gat gtc ctg ggt tac ctg cgt aaa gtt tgg gag ggc       1968
Glu Gln Gly Arg Asp Val Leu Gly Tyr Leu Arg Lys Val Trp Glu Gly           
                645                 650                 655               

ctg ctg gcc tcc tat acc aag gaa gcg gag tgg tcc gct gct aaa tat       2016
Leu Leu Ala Ser Tyr Thr Lys Glu Ala Glu Trp Ser Ala Ala Lys Tyr           
            660                 665                 670                   

gtg ccg act ttc aac gag tat gtc gag aac gct aaa gtt agc atc gcg       2064
Val Pro Thr Phe Asn Glu Tyr Val Glu Asn Ala Lys Val Ser Ile Ala           
        675                 680                 685                       

ctg gcg acc gtt gtt ctg aac tcc atc ttc ttc acc ggc gaa ctg ctg       2112
Leu Ala Thr Val Val Leu Asn Ser Ile Phe Phe Thr Gly Glu Leu Leu           
    690                 695                 700                           

ccg gat tat att ctg cag caa gtt gac ctg cgt agc aaa ttt ctg cac       2160
Pro Asp Tyr Ile Leu Gln Gln Val Asp Leu Arg Ser Lys Phe Leu His           
705                 710                 715                 720           

ctg gtt tcc ctg acc ggc cgt ctg att aac gac acc aaa acc tat cag       2208
Leu Val Ser Leu Thr Gly Arg Leu Ile Asn Asp Thr Lys Thr Tyr Gln           
                725                 730                 735               

gct gaa cgt aac cgt ggt gag ctg gtg agc agc gtg cag tgc tac atg       2256
Ala Glu Arg Asn Arg Gly Glu Leu Val Ser Ser Val Gln Cys Tyr Met           
            740                 745                 750                   

cgt gag aac ccg gag tgt acc gag gag gaa gct ctg tct cat gtt tac       2304
Arg Glu Asn Pro Glu Cys Thr Glu Glu Glu Ala Leu Ser His Val Tyr           
        755                 760                 765                       

ggc att att gat aac gca ctg aaa gag ctg aac tgg gag ctg gcg aac       2352
Gly Ile Ile Asp Asn Ala Leu Lys Glu Leu Asn Trp Glu Leu Ala Asn           
    770                 775                 780                           

cca gcg agc aac gct ccg ctg tgc gtt cgt cgt ctg ctg ttc aac acc       2400
Pro Ala Ser Asn Ala Pro Leu Cys Val Arg Arg Leu Leu Phe Asn Thr           
785                 790                 795                 800           

gcg cgt gta atg cag ctg ttc tac atg tac cgc gat ggc ttc ggc atc       2448
Ala Arg Val Met Gln Leu Phe Tyr Met Tyr Arg Asp Gly Phe Gly Ile           
                805                 810                 815               

agc gat aaa gaa atg aaa gat cat gtg tct cgc acc ctg ttt gac ccg       2496
Ser Asp Lys Glu Met Lys Asp His Val Ser Arg Thr Leu Phe Asp Pro           
            820                 825                 830                   

gta gca taa                                                           2505
Val Ala                                                                   
                                                                          


<210>  146
<211>  834
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  146

Met Ala Gln His Cys Val Arg Ser His Leu Arg Leu Arg Trp Asn Cys 
1               5                   10                  15      


Val Gly Ile His Ala Ser Ala Ala Glu Thr Arg Pro Asp Gln Leu Pro 
            20                  25                  30          


Gln Glu Glu Arg Phe Val Ser Arg Leu Asn Ala Asp Tyr His Pro Ala 
        35                  40                  45              


Val Trp Lys Asp Asp Phe Ile Asp Ser Leu Thr Ser Pro Asn Ser His 
    50                  55                  60                  


Ala Thr Ser Lys Ser Ser Val Asp Glu Thr Ile Asn Lys Arg Ile Gln 
65                  70                  75                  80  


Thr Leu Val Lys Glu Ile Gln Cys Met Phe Gln Ser Met Gly Asp Gly 
                85                  90                  95      


Glu Thr Asn Pro Ser Ala Tyr Asp Thr Ala Trp Val Ala Arg Ile Pro 
            100                 105                 110         


Ser Ile Asp Gly Ser Gly Ala Pro Gln Phe Pro Gln Thr Leu Gln Trp 
        115                 120                 125             


Ile Leu Asn Asn Gln Leu Pro Asp Gly Ser Trp Gly Glu Glu Cys Ile 
    130                 135                 140                 


Phe Leu Ala Tyr Asp Arg Val Leu Asn Thr Leu Ala Cys Leu Leu Thr 
145                 150                 155                 160 


Leu Lys Ile Trp Asn Lys Gly Asp Ile Gln Val Gln Lys Gly Val Glu 
                165                 170                 175     


Phe Val Arg Lys His Met Glu Glu Met Lys Asp Glu Ala Asp Asn His 
            180                 185                 190         


Arg Pro Ser Gly Phe Glu Val Val Phe Pro Ala Met Leu Asp Glu Ala 
        195                 200                 205             


Lys Ser Leu Gly Leu Asp Leu Pro Tyr His Leu Pro Phe Ile Ser Gln 
    210                 215                 220                 


Ile His Gln Lys Arg Gln Lys Lys Leu Gln Lys Ile Pro Leu Asn Val 
225                 230                 235                 240 


Leu His Asn His Gln Thr Ala Leu Leu Tyr Ser Leu Glu Gly Leu Gln 
                245                 250                 255     


Asp Val Val Asp Trp Gln Glu Ile Thr Asn Leu Gln Ser Arg Asp Gly 
            260                 265                 270         


Ser Phe Leu Ser Ser Pro Ala Ser Thr Ala Cys Val Phe Met His Thr 
        275                 280                 285             


Gln Asn Lys Arg Cys Leu His Phe Leu Asn Phe Val Leu Ser Lys Phe 
    290                 295                 300                 


Gly Asp Tyr Val Pro Cys His Tyr Pro Leu Asp Leu Phe Glu Arg Leu 
305                 310                 315                 320 


Trp Ala Val Asp Thr Val Glu Arg Leu Gly Ile Asp Arg Tyr Phe Lys 
                325                 330                 335     


Lys Glu Ile Lys Glu Ser Leu Asp Tyr Val Tyr Arg Tyr Trp Asp Ala 
            340                 345                 350         


Glu Arg Gly Val Gly Trp Ala Arg Cys Asn Pro Ile Pro Asp Val Asp 
        355                 360                 365             


Asp Thr Ala Met Gly Leu Arg Ile Leu Arg Leu His Gly Tyr Asn Val 
    370                 375                 380                 


Ser Ser Asp Val Leu Glu Asn Phe Arg Asp Glu Lys Gly Asp Phe Phe 
385                 390                 395                 400 


Cys Phe Ala Gly Gln Thr Gln Ile Gly Val Thr Asp Asn Leu Asn Leu 
                405                 410                 415     


Tyr Arg Cys Ser Gln Val Cys Phe Pro Gly Glu Lys Ile Met Glu Glu 
            420                 425                 430         


Ala Lys Thr Phe Thr Thr Asn His Leu Gln Asn Ala Leu Ala Lys Asn 
        435                 440                 445             


Asn Ala Phe Asp Lys Trp Ala Val Lys Lys Asp Leu Pro Gly Glu Val 
    450                 455                 460                 


Glu Tyr Ala Ile Lys Tyr Pro Trp His Arg Ser Met Pro Arg Leu Glu 
465                 470                 475                 480 


Ala Arg Ser Tyr Ile Glu Gln Phe Gly Ser Asn Asp Val Trp Leu Gly 
                485                 490                 495     


Lys Thr Val Tyr Lys Met Leu Tyr Val Ser Asn Glu Lys Tyr Leu Glu 
            500                 505                 510         


Leu Ala Lys Leu Asp Phe Asn Met Val Gln Ala Leu His Gln Lys Glu 
        515                 520                 525             


Thr Gln His Ile Val Ser Trp Trp Arg Glu Ser Gly Phe Asn Asp Leu 
    530                 535                 540                 


Thr Phe Thr Arg Gln Arg Pro Val Glu Met Tyr Phe Ser Val Ala Val 
545                 550                 555                 560 


Ser Met Phe Glu Pro Glu Phe Ala Ala Cys Arg Ile Ala Tyr Ala Lys 
                565                 570                 575     


Thr Ser Cys Leu Ala Val Ile Leu Asp Asp Leu Tyr Asp Thr His Gly 
            580                 585                 590         


Ser Leu Asp Asp Leu Lys Leu Phe Ser Glu Ala Val Arg Arg Trp Asp 
        595                 600                 605             


Ile Ser Val Leu Asp Ser Val Arg Asp Asn Gln Leu Lys Val Cys Phe 
    610                 615                 620                 


Leu Gly Leu Tyr Asn Thr Val Asn Gly Phe Gly Lys Asp Gly Leu Lys 
625                 630                 635                 640 


Glu Gln Gly Arg Asp Val Leu Gly Tyr Leu Arg Lys Val Trp Glu Gly 
                645                 650                 655     


Leu Leu Ala Ser Tyr Thr Lys Glu Ala Glu Trp Ser Ala Ala Lys Tyr 
            660                 665                 670         


Val Pro Thr Phe Asn Glu Tyr Val Glu Asn Ala Lys Val Ser Ile Ala 
        675                 680                 685             


Leu Ala Thr Val Val Leu Asn Ser Ile Phe Phe Thr Gly Glu Leu Leu 
    690                 695                 700                 


Pro Asp Tyr Ile Leu Gln Gln Val Asp Leu Arg Ser Lys Phe Leu His 
705                 710                 715                 720 


Leu Val Ser Leu Thr Gly Arg Leu Ile Asn Asp Thr Lys Thr Tyr Gln 
                725                 730                 735     


Ala Glu Arg Asn Arg Gly Glu Leu Val Ser Ser Val Gln Cys Tyr Met 
            740                 745                 750         


Arg Glu Asn Pro Glu Cys Thr Glu Glu Glu Ala Leu Ser His Val Tyr 
        755                 760                 765             


Gly Ile Ile Asp Asn Ala Leu Lys Glu Leu Asn Trp Glu Leu Ala Asn 
    770                 775                 780                 


Pro Ala Ser Asn Ala Pro Leu Cys Val Arg Arg Leu Leu Phe Asn Thr 
785                 790                 795                 800 


Ala Arg Val Met Gln Leu Phe Tyr Met Tyr Arg Asp Gly Phe Gly Ile 
                805                 810                 815     


Ser Asp Lys Glu Met Lys Asp His Val Ser Arg Thr Leu Phe Asp Pro 
            820                 825                 830         


Val Ala 
        


