
                                SEQUENCE LISTING

<110> CENTOCOR ORTHO BIOTECH INC.

<120> ANTIBODY GLYCOSYLATION VARIANTS

<130> CEN5274PCT

<140> TO BE ASSIGNED      
<141> 2010-10-25  

<150> 61/255986          
<151> 2009-10-29  

<160> 2

<170> FastSEQ for Windows Version 4.0

<210> 1
<211> 222
<212> PRT
<213> Homo sapiens

<220>
<221> Mutagen
<222> (3)
<223> Wherein Xaa at position (3) can be Serine or Proline

<220>
<221> Mutagen
<222> (9)
<223> Wherein Xaa at position (9) can be Phenylalanine or Leucine

<220>
<221> Mutagen
<222> (10)
<223> Wherein Xaa at position (10) can be Phenylalanine or Leucine

<220>
<221> Mutagen
<222> (74)
<223> Wherein Xaa at position (74) can be Threonie or Asparagine

<220>
<221> Mutagen
<222> (134)
<223> Wherein Xaa at position (134) can be Threonine or Asparagine

<220>
<221> Mutagen
<222> (136)
<223> Wherein Xaa at position (136) can be Threonine or Asparagine and 	when Xaa at position (134) is Threonine then Xaa at position (136) 	is Asparagine

<220>
<221> Mutagen
<222> (157)
<223> Wherein Xaa at position (157) can be Threonine or Asparagine

<220>
<221> Mutagen
<222> (159)
<223> Wherein Xaa at position (159) can be Threonine or Asparagine and 	when Xaa at position (134) is Asparagine then Xaa at position (136) 	is Threonone

<220>
<221> Mutagen
<222> (194)
<223> Wherein Xaa at position (194) can be Threonine or Asparagine

<220>
<221> Mutagen
<222> (196)
<223> Wherein Xaa at position (196) can be Threonine or Asparagine and 
when Xaa at position (134) is Asparagine then Xaa at position (196) is Threonine.
           

<400> 1
Cys Pro Xaa Cys Pro Ala Pro Glu Xaa Xaa Gly Gly Pro Ser Val Phe
 1               5                  10                  15      
Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro
            20                  25                  30          
Glu Val Thr Cys Val Val Val Asp Val Ser Gln Glu Asp Pro Glu Val
        35                  40                  45              
Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr
    50                  55                  60                  
Lys Pro Arg Glu Glu Gln Phe Asn Ser Xaa Tyr Arg Val Val Ser Val
65                  70                  75                  80  
Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys
                85                  90                  95      
Lys Val Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile Ser
            100                 105                 110         
Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro
        115                 120                 125             
Ser Gln Glu Glu Met Xaa Lys Xaa Gln Val Ser Leu Thr Cys Leu Val
    130                 135                 140                 
Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Xaa Ser Xaa Gly
145                 150                 155                 160 
Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp
                165                 170                 175     
Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg Trp
            180                 185                 190         
Gln Xaa Gly Xaa Val Phe Ser Cys Ser Val Met His Glu Ala Leu His
        195                 200                 205             
Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly Lys
    210                 215                 220         


<210> 2
<211> 222
<212> PRT
<213> Homo sapiens

<220>
<221> Mutagen
<221> (9)(10)
<223> Wherein Xaa at positions (9) and (10) may be Alanine or Leucine

<220>
<221> Mutagen
<221> (74)
<223> Wherein Xaa at positions (74)may be Threonine or Asparagine


<220>
<221> Mutagen
<222> (134)
<223> Wherein Xaa at position (134) can be Threonine or Asparagine 

<220>
<221> Mutagen
<222> (136)
<223> Wherein Xaa at position (136) can be Threonine or Asparagine and 	when Xaa at position (134) is Asparagine then Xaa at position (136) 	is Threonine

<220>
<221> Mutagen
<222> (194)
<223> Wherein Xaa at position (194) can be Glutamine or Asparagine

<220>
<221> Mutagen
<222> (196)
<223> Wherein Xaa at position (196) can be Asparagine or Threonine 


<400> 2
Cys Pro Pro Cys Pro Ala Pro Glu Xaa Xaa Gly Gly Pro Ser Val Phe
 1               5                  10                  15      
Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro
            20                  25                  30          
Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val
        35                  40                  45              
Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr
    50                  55                  60                  
Lys Pro Arg Glu Glu Gln Tyr Asn Ser Xaa Tyr Arg Val Val Ser Val
65                  70                  75                  80  
Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys
                85                  90                  95      
Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser
            100                 105                 110         
Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro
        115                 120                 125             
Ser Arg Asp Glu Leu Xaa Lys Xaa Gln Val Ser Leu Thr Cys Leu Val
    130                 135                 140                 
Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly
145                 150                 155                 160 
Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp
                165                 170                 175     
Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp
            180                 185                 190         
Gln Xaa Gly Xaa Val Phe Ser Cys Ser Val Met His Glu Ala Leu His
        195                 200                 205             
Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys
    210                 215                 220         

