                         SEQUENCE LISTING

<110>  Universit Joseph Fourier et al.
 
<120>  Contrle de la fertilit humaine via DPY19L2

<130>  BR063865/HL/PCA

<160>  18    

<170>  PatentIn version 3.5

<210>  1
<211>  758
<212>  PRT
<213>  Homo sapiens

<400>  1

Met Arg Lys Gln Gly Val Ser Ser Lys Arg Leu Gln Ser Ser Gly Arg 
1               5                   10                  15      


Ser Gln Ser Lys Gly Arg Arg Gly Ala Ser Leu Ala Arg Glu Pro Glu 
            20                  25                  30          


Val Glu Glu Glu Met Glu Lys Ser Ala Leu Gly Gly Gly Lys Leu Pro 
        35                  40                  45              


Arg Gly Ser Trp Arg Ser Ser Pro Gly Arg Ile Gln Ser Leu Lys Glu 
    50                  55                  60                  


Arg Lys Gly Leu Glu Leu Glu Val Val Ala Lys Thr Phe Leu Leu Gly 
65                  70                  75                  80  


Pro Phe Gln Phe Val Arg Asn Ser Leu Ala Gln Leu Arg Glu Lys Val 
                85                  90                  95      


Gln Glu Leu Gln Ala Arg Arg Phe Ser Ser Arg Thr Thr Leu Gly Ile 
            100                 105                 110         


Ala Val Phe Val Ala Ile Leu His Trp Leu His Leu Val Thr Leu Phe 
        115                 120                 125             


Glu Asn Asp Arg His Phe Ser His Leu Ser Ser Leu Glu Arg Glu Met 
    130                 135                 140                 


Thr Phe Arg Thr Glu Met Gly Leu Tyr Tyr Ser Tyr Phe Lys Thr Ile 
145                 150                 155                 160 


Ile Glu Ala Pro Ser Phe Leu Glu Gly Leu Trp Met Ile Met Asn Asp 
                165                 170                 175     


Arg Leu Thr Glu Tyr Pro Leu Ile Ile Asn Ala Ile Lys Arg Phe His 
            180                 185                 190         


Leu Tyr Pro Glu Val Ile Ile Ala Ser Trp Tyr Cys Thr Phe Met Gly 
        195                 200                 205             


Ile Met Asn Leu Phe Gly Leu Glu Thr Lys Thr Cys Trp Asn Val Thr 
    210                 215                 220                 


Arg Ile Glu Pro Leu Asn Glu Val Gln Ser Cys Glu Gly Leu Gly Asp 
225                 230                 235                 240 


Pro Ala Cys Phe Tyr Val Gly Val Ile Phe Ile Leu Asn Gly Leu Met 
                245                 250                 255     


Met Gly Leu Phe Phe Met Tyr Gly Ala Tyr Leu Ser Gly Thr Gln Leu 
            260                 265                 270         


Gly Gly Leu Ile Thr Val Leu Cys Phe Phe Phe Asn His Gly Glu Ala 
        275                 280                 285             


Thr Arg Val Met Trp Thr Pro Pro Leu Arg Glu Ser Phe Ser Tyr Pro 
    290                 295                 300                 


Phe Leu Val Leu Gln Met Cys Ile Leu Thr Leu Ile Leu Arg Thr Ser 
305                 310                 315                 320 


Ser Asn Asp Arg Arg Pro Phe Ile Ala Leu Cys Leu Ser Asn Val Ala 
                325                 330                 335     


Phe Met Leu Pro Trp Gln Phe Ala Gln Phe Ile Leu Phe Thr Gln Ile 
            340                 345                 350         


Ala Ser Leu Phe Pro Met Tyr Val Val Gly Tyr Ile Glu Pro Ser Lys 
        355                 360                 365             


Phe Gln Lys Ile Ile Tyr Met Asn Met Ile Ser Val Thr Leu Ser Phe 
    370                 375                 380                 


Ile Leu Met Phe Gly Asn Ser Met Tyr Leu Ser Ser Tyr Tyr Ser Ser 
385                 390                 395                 400 


Ser Leu Leu Met Thr Trp Ala Ile Ile Leu Lys Arg Asn Glu Ile Gln 
                405                 410                 415     


Lys Leu Gly Val Ser Lys Leu Asn Phe Trp Leu Ile Gln Gly Ser Ala 
            420                 425                 430         


Trp Trp Cys Gly Thr Ile Ile Leu Lys Phe Leu Thr Ser Lys Ile Leu 
        435                 440                 445             


Gly Val Ser Asp His Ile Arg Leu Ser Asp Leu Ile Ala Ala Arg Ile 
    450                 455                 460                 


Leu Arg Tyr Thr Asp Phe Asp Thr Leu Ile Tyr Thr Cys Ala Pro Glu 
465                 470                 475                 480 


Phe Asp Phe Met Glu Lys Ala Thr Pro Leu Arg Tyr Thr Lys Thr Leu 
                485                 490                 495     


Leu Leu Pro Val Val Met Val Ile Thr Cys Phe Ile Phe Lys Lys Thr 
            500                 505                 510         


Val Arg Asp Ile Ser Tyr Val Leu Ala Thr Asn Ile Tyr Leu Arg Lys 
        515                 520                 525             


Gln Leu Leu Glu His Ser Glu Leu Ala Phe His Thr Leu Gln Leu Leu 
    530                 535                 540                 


Val Phe Thr Ala Leu Ala Ile Leu Ile Met Arg Leu Lys Met Phe Leu 
545                 550                 555                 560 


Thr Pro His Met Cys Val Met Ala Ser Leu Ile Cys Ser Arg Gln Leu 
                565                 570                 575     


Phe Gly Trp Leu Phe Arg Arg Val Arg Phe Glu Lys Val Ile Phe Gly 
            580                 585                 590         


Ile Leu Thr Val Met Ser Ile Gln Gly Tyr Ala Asn Leu Arg Asn Gln 
        595                 600                 605             


Trp Ser Ile Ile Gly Glu Phe Asn Asn Leu Pro Gln Glu Glu Leu Leu 
    610                 615                 620                 


Gln Trp Ile Lys Tyr Ser Thr Thr Ser Asp Ala Val Phe Ala Gly Ala 
625                 630                 635                 640 


Met Pro Thr Met Ala Ser Ile Lys Leu Ser Thr Leu His Pro Ile Val 
                645                 650                 655     


Asn His Pro His Tyr Glu Asp Ala Asp Leu Arg Ala Arg Thr Lys Ile 
            660                 665                 670         


Val Tyr Ser Thr Tyr Ser Arg Lys Ser Ala Lys Glu Val Arg Asp Lys 
        675                 680                 685             


Leu Leu Glu Leu His Val Asn Tyr Tyr Val Leu Glu Glu Ala Trp Cys 
    690                 695                 700                 


Val Val Arg Thr Lys Pro Gly Cys Ser Met Leu Glu Ile Trp Asp Val 
705                 710                 715                 720 


Glu Asp Pro Ser Asn Ala Ala Asn Pro Pro Leu Cys Ser Val Leu Leu 
                725                 730                 735     


Glu Asp Ala Arg Pro Tyr Phe Thr Thr Val Phe Gln Asn Ser Val Tyr 
            740                 745                 750         


Arg Val Leu Lys Val Asn 
        755             


<210>  2
<211>  2277
<212>  DNA
<213>  Homo sapiens

<400>  2
atgagaaaac aaggagtaag ctcaaagcgg ctgcaatctt ccggccgcag ccagtctaag       60

gggcggcgcg gggcctccct cgcccgggag ccggaggtag aggaggagat ggaaaagtcg      120

gccctaggcg gcgggaaact gccaaggggc tcctggaggt cctccccggg gaggatccaa      180

agtctgaaag agcgaaaagg cttggagcta gaggtggtgg ccaagacctt tcttctcggc      240

cccttccagt tcgtccgtaa ttccctggcg cagctccggg aaaaggtgca ggaactgcag      300

gcgcggcggt tctccagcag aaccactctc ggcatcgctg tctttgtggc aattttacat      360

tggttacatt tagtaacact ttttgaaaat gatcgtcatt tctctcacct ctcatctttg      420

gaacgggaga tgacttttcg cactgaaatg ggactttatt attcatactt caagaccatt      480

attgaagcac cttcgttttt ggaaggactg tggatgatta tgaatgacag gcttactgaa      540

tatcctctta taattaatgc aataaaacgc ttccatcttt atccagaggt aatcatagcc      600

tcctggtatt gcacattcat gggaataatg aatttatttg gactagaaac taagacctgc      660

tggaatgtca ccagaataga acctcttaat gaagttcaaa gctgtgaagg attgggagat      720

cctgcttgct tttatgttgg tgtaatcttt attttaaatg gactaatgat gggattgttc      780

ttcatgtatg gagcatacct gagtgggact caactgggag gtcttattac agtactgtgc      840

ttctttttca accatggaga ggccacccgt gtgatgtgga caccacctct ccgtgaaagt      900

ttttcctatc ctttccttgt acttcagatg tgtattttaa ctttgattct caggacctca      960

agcaatgata gaaggccctt cattgcactc tgtctttcca atgttgcttt tatgcttccc     1020

tggcaatttg ctcagtttat actttttaca cagatagcat cattatttcc catgtatgtt     1080

gtgggataca ttgaaccaag caaatttcag aagatcattt atatgaacat gatttcagtt     1140

acccttagtt tcattttgat gtttggaaat tcaatgtact tatcttctta ttattcttca     1200

tctttgttaa tgacgtgggc aataattcta aagagaaatg aaattcaaaa actgggagta     1260

tctaaactca acttttggct aattcaaggt agtgcctggt ggtgtggaac aatcattttg     1320

aaatttctga catctaaaat cttaggcgtt tcagaccaca ttcgcctgag tgatcttata     1380

gcagccagaa tcttaaggta tacagatttt gatactttaa tatatacctg tgctcccgaa     1440

tttgacttca tggaaaaagc gactccgctg agatacacaa agacattatt gcttccagtt     1500

gttatggtga ttacatgttt tatctttaaa aagactgttc gtgatatttc atatgtttta     1560

gctacaaaca tttatctaag aaaacagctc cttgaacaca gtgagctggc ttttcacaca     1620

ttgcagttgt tagtgtttac tgcccttgcc attttaatta tgaggctaaa gatgtttttg     1680

acaccgcaca tgtgtgttat ggcttccttg atatgctctc gacagctctt tggctggctt     1740

tttcgcagag ttcgttttga gaaggttatc tttggcattt taacagtgat gtcaatacaa     1800

ggttatgcaa acctccgtaa tcaatggagc ataataggag aatttaataa tttgcctcag     1860

gaagaacttt tacagtggat caaatacagt accacatcag atgctgtctt tgcaggtgcc     1920

atgcctacaa tggcaagcat caagctgtct acacttcatc ccattgtgaa tcatccacat     1980

tacgaagatg cagacttgag ggctcggaca aaaatagttt attctacata tagtcgaaaa     2040

tctgccaaag aagtaagaga taaattgttg gagttacatg tgaattatta tgttttagaa     2100

gaggcatggt gtgttgtgag aactaagcct ggttgcagta tgcttgaaat ctgggatgtg     2160

gaagaccctt ccaatgcagc taaccctccc ttatgtagcg tcctgctcga agacgccagg     2220

ccttacttca ccacagtatt tcagaatagt gtgtacagag tattaaaggt taactga        2277


<210>  3
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer 3'DPY19L2

<400>  3
ccctcaagca attctctttg                                                   20


<210>  4
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer 3'DPY19L2

<400>  4
gatttgattt ggggcctaa                                                    19


<210>  5
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer 3'DPY19L2

<400>  5
gattaaagtt ctggggtgag                                                   20


<210>  6
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer 3'DPY19L2

<400>  6
gcagcctatt acttccgata                                                   20


<210>  7
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer exon 22 DPY19L2

<400>  7
gtgtctgtta ttaaagcttg tg                                                22


<210>  8
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer exon 22 DPY19L2

<400>  8
attgtctcta gacagcaata cat                                               23


<210>  9
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer exon 11 DPY19L2

<400>  9
aacctcctca agtgacttag                                                   20


<210>  10
<211>  16
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer exon 11 DPY19L2

<400>  10
ttggccaaga gtcatt                                                       16


<210>  11
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer exon 1 DPY19L2

<400>  11
ggccaacttc tttctactcg gac                                               23


<210>  12
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer exon 1 DPY19L2

<400>  12
gacccagctc caccatactc ctt                                               23


<210>  13
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer 5'DPY19L2

<400>  13
ctactattgt ctcaaccaaa tatgt                                             25


<210>  14
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer 5'DPY19L2

<400>  14
ggaattcaag actagcctag aa                                                22


<210>  15
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer 5'DPY19L2

<400>  15
ggcatggaag ttaccacaag aa                                                22


<210>  16
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer 5'DPY19L2

<400>  16
gttacaccac tggccgtctc                                                   20


<210>  17
<211>  27
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer DPY19L2

<400>  17
aaatctagac acagtcacag catcatc                                           27


<210>  18
<211>  27
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer DPY19L2

<400>  18
agaggcttaa taggtgaaag aaagaga                                           27


