                         SEQUENCE LISTING

<110>  Novici Biotech LLC
       Padgett, Hal S
 
<120>  GENERATION OF ANTIGENIC VIRUS-LIKE PARTICLES THROUGH 
       PROTEIN-PROTEIN LINKAGES

<130>  NBT1006

<150>  US 61/258,152
<151>  2009-11-05

<160>  10    

<170>  PatentIn version 3.5

<210>  1
<211>  5
<212>  PRT
<213>  Drosophila melanogaster

<400>  1

Thr Glu Phe Cys Ala 
1               5   


<210>  2
<211>  15
<212>  PRT
<213>  Drosophila melanogaster

<400>  2

Glu Glu Glu Ala Tyr Lys Thr Gln Gly Lys Thr Glu Phe Cys Ala 
1               5                   10                  15  


<210>  3
<211>  97
<212>  PRT
<213>  Drosophila melanogaster

<400>  3

Ala Gly Glu Leu Ile His Met Val Thr Leu Asp Lys Thr Gly Lys Lys 
1               5                   10                  15      


Ser Phe Gly Ile Cys Ile Val Arg Gly Glu Val Lys Asp Ser Pro Asn 
            20                  25                  30          


Thr Lys Thr Thr Gly Ile Phe Ile Lys Gly Ile Val Pro Asp Ser Pro 
        35                  40                  45              


Ala His Leu Cys Gly Arg Leu Lys Val Gly Asp Arg Ile Leu Ser Leu 
    50                  55                  60                  


Asn Gly Lys Asp Val Arg Asn Ser Thr Glu Gln Ala Val Ile Asp Leu 
65                  70                  75                  80  


Ile Lys Glu Ala Asp Phe Lys Ile Glu Leu Glu Ile Gln Thr Phe Asp 
                85                  90                  95      


Lys 
    


<210>  4
<211>  12
<212>  PRT
<213>  Homo sapiens

<400>  4

Gly Phe Cys Cys Ser His Gln Gln Gln Tyr Asp Cys 
1               5                   10          


<210>  5
<211>  282
<212>  PRT
<213>  Homo sapiens

<400>  5

Met Ser Ser Leu Tyr Pro Ser Leu Glu Asp Leu Lys Val Asp Gln Ala 
1               5                   10                  15      


Ile Gln Ala Gln Val Arg Ala Ser Pro Lys Met Pro Ala Leu Pro Val 
            20                  25                  30          


Gln Ala Thr Ala Ile Ser Pro Pro Pro Val Leu Tyr Pro Asn Leu Ala 
        35                  40                  45              


Glu Leu Glu Asn Tyr Met Gly Leu Ser Leu Ser Ser Gln Glu Val Gln 
    50                  55                  60                  


Glu Ser Leu Leu Gln Ile Pro Glu Gly Asp Ser Met Val Ala Pro Val 
65                  70                  75                  80  


Thr Gly Tyr Ser Leu Gly Val Arg Arg Ala Glu Ile Lys Pro Gly Val 
                85                  90                  95      


Arg Glu Ile His Leu Cys Lys Asp Glu Arg Gly Lys Thr Gly Leu Arg 
            100                 105                 110         


Leu Arg Lys Val Asp Gln Gly Leu Phe Val Gln Leu Val Gln Ala Asn 
        115                 120                 125             


Thr Pro Ala Ser Leu Val Gly Leu Arg Phe Gly Asp Gln Leu Leu Gln 
    130                 135                 140                 


Ile Asp Gly Arg Asp Cys Ala Gly Trp Ser Ser His Lys Ala His Gln 
145                 150                 155                 160 


Val Val Lys Lys Ala Ser Gly Asp Lys Ile Val Val Val Val Arg Asp 
                165                 170                 175     


Arg Pro Phe Gln Arg Thr Val Thr Met His Lys Asp Ser Met Gly His 
            180                 185                 190         


Val Gly Phe Val Ile Lys Lys Gly Lys Ile Val Ser Leu Val Lys Gly 
        195                 200                 205             


Ser Ser Ala Ala Arg Asn Gly Leu Leu Thr Asn His Tyr Val Cys Glu 
    210                 215                 220                 


Val Asp Gly Gln Asn Val Ile Gly Leu Lys Asp Lys Lys Ile Met Glu 
225                 230                 235                 240 


Ile Leu Ala Thr Ala Gly Asn Val Val Thr Leu Thr Ile Ile Pro Ser 
                245                 250                 255     


Val Ile Tyr Glu His Met Val Lys Lys Leu Pro Pro Val Leu Leu His 
            260                 265                 270         


His Thr Met Asp His Ser Ile Pro Asp Ala 
        275                 280         


<210>  6
<211>  163
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  fusion of TMV U1 CP and TEFCA

<400>  6

Met Ser Tyr Ser Ile Thr Thr Pro Ser Gln Phe Val Phe Leu Ser Ser 
1               5                   10                  15      


Ala Trp Ala Asp Pro Ile Glu Leu Ile Asn Leu Cys Thr Asn Ala Leu 
            20                  25                  30          


Gly Asn Gln Phe Gln Thr Gln Gln Ala Arg Thr Val Val Gln Arg Gln 
        35                  40                  45              


Phe Ser Glu Val Trp Lys Pro Ser Pro Gln Val Thr Val Arg Phe Pro 
    50                  55                  60                  


Asp Ser Asp Phe Lys Val Tyr Arg Tyr Asn Ala Val Leu Asp Pro Leu 
65                  70                  75                  80  


Val Thr Ala Leu Leu Gly Ala Phe Asp Thr Arg Asn Arg Ile Ile Glu 
                85                  90                  95      


Val Glu Asn Gln Ala Asn Pro Thr Thr Ala Glu Thr Leu Asp Ala Thr 
            100                 105                 110         


Arg Arg Val Asp Asp Ala Thr Val Ala Ile Arg Ser Ala Ile Asn Asn 
        115                 120                 125             


Leu Ile Val Glu Leu Ile Arg Gly Thr Gly Ser Tyr Asn Arg Ser Ser 
    130                 135                 140                 


Phe Glu Ser Ser Ser Gly Leu Val Trp Thr Ser Gly Pro Ala Thr Glu 
145                 150                 155                 160 


Phe Cys Ala 
            


<210>  7
<211>  166
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  fusion of TMV U1 CP and TEFCA with GG spacer

<400>  7

Met Ser Tyr Ser Ile Thr Thr Pro Ser Gln Phe Val Phe Leu Ser Ser 
1               5                   10                  15      


Ala Trp Ala Asp Pro Ile Glu Leu Ile Asn Leu Cys Thr Asn Ala Leu 
            20                  25                  30          


Gly Asn Gln Phe Gln Thr Gln Gln Ala Arg Thr Val Val Gln Arg Gln 
        35                  40                  45              


Phe Ser Glu Val Trp Lys Pro Ser Pro Gln Val Thr Val Arg Phe Pro 
    50                  55                  60                  


Asp Ser Asp Phe Lys Val Tyr Arg Tyr Asn Ala Val Leu Asp Pro Leu 
65                  70                  75                  80  


Val Thr Ala Leu Leu Gly Ala Phe Asp Thr Arg Asn Arg Ile Ile Glu 
                85                  90                  95      


Val Glu Asn Gln Ala Asn Pro Thr Thr Ala Glu Thr Leu Asp Ala Thr 
            100                 105                 110         


Arg Arg Val Asp Asp Ala Thr Val Ala Ile Arg Ser Ala Ile Asn Asn 
        115                 120                 125             


Leu Ile Val Glu Leu Ile Arg Gly Thr Gly Ser Tyr Asn Arg Ser Ser 
    130                 135                 140                 


Phe Glu Ser Ser Ser Gly Leu Val Trp Thr Ser Gly Pro Ala Thr Gly 
145                 150                 155                 160 


Gly Thr Glu Phe Cys Ala 
                165     


<210>  8
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  polyhistidine-tagged INAD

<400>  8

Met Ser Ala Gly Glu Leu Ile His Met Val Thr Leu Asp Lys Thr Gly 
1               5                   10                  15      


Lys Lys Ser Phe Gly Ile Cys Ile Val Arg Gly Glu Val Lys Asp Ser 
            20                  25                  30          


Pro Asn Thr Lys Thr Thr Gly Ile Phe Ile Lys Gly Ile Val Pro Asp 
        35                  40                  45              


Ser Pro Ala His Leu Cys Gly Arg Leu Lys Val Gly Asp Arg Ile Leu 
    50                  55                  60                  


Ser Leu Asn Gly Lys Asp Val Arg Asn Ser Thr Glu Gln Ala Val Ile 
65                  70                  75                  80  


Asp Leu Ile Lys Glu Ala Asp Phe Lys Ile Glu Leu Glu Ile Gln Thr 
                85                  90                  95      


Phe Asp Lys Gly Gly His His His His His His 
            100                 105         


<210>  9
<211>  350
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  polyhistidine-tagged INAD-GFP IGH fusion

<400>  9

Met Ser Ala Gly Glu Leu Ile His Met Val Thr Leu Asp Lys Thr Gly 
1               5                   10                  15      


Lys Lys Ser Phe Gly Ile Cys Ile Val Arg Gly Glu Val Lys Asp Ser 
            20                  25                  30          


Pro Asn Thr Lys Thr Thr Gly Ile Phe Ile Lys Gly Ile Val Pro Asp 
        35                  40                  45              


Ser Pro Ala His Leu Cys Gly Arg Leu Lys Val Gly Asp Arg Ile Leu 
    50                  55                  60                  


Ser Leu Asn Gly Lys Asp Val Arg Asn Ser Thr Glu Gln Ala Val Ile 
65                  70                  75                  80  


Asp Leu Ile Lys Glu Ala Asp Phe Lys Ile Glu Leu Glu Ile Gln Thr 
                85                  90                  95      


Phe Asp Lys Gly Gly Ser Gly Met Ala Ser Lys Gly Glu Glu Leu Phe 
            100                 105                 110         


Thr Gly Val Val Pro Ile Leu Val Glu Leu Asp Gly Asp Val Asn Gly 
        115                 120                 125             


His Lys Phe Ser Val Ser Gly Glu Gly Glu Gly Asp Ala Thr Tyr Gly 
    130                 135                 140                 


Lys Leu Thr Leu Lys Phe Ile Cys Thr Thr Gly Lys Leu Pro Val Pro 
145                 150                 155                 160 


Trp Pro Thr Leu Val Thr Thr Phe Ser Tyr Gly Val Gln Cys Phe Ser 
                165                 170                 175     


Arg Tyr Pro Asp His Met Lys Arg His Asp Phe Phe Lys Ser Ala Met 
            180                 185                 190         


Pro Glu Gly Tyr Val Gln Glu Arg Thr Ile Ser Phe Lys Asp Asp Gly 
        195                 200                 205             


Asn Tyr Lys Thr Arg Ala Glu Val Lys Phe Glu Gly Asp Thr Leu Val 
    210                 215                 220                 


Asn Arg Ile Glu Leu Lys Gly Ile Asp Phe Lys Glu Asp Gly Asn Ile 
225                 230                 235                 240 


Leu Gly His Lys Leu Glu Tyr Asn Tyr Asn Ser His Asn Val Tyr Ile 
                245                 250                 255     


Thr Ala Asp Lys Gln Lys Asn Gly Ile Lys Ala Asn Phe Lys Ile Arg 
            260                 265                 270         


His Asn Ile Glu Asp Gly Ser Val Gln Leu Ala Asp His Tyr Gln Gln 
        275                 280                 285             


Asn Thr Pro Ile Gly Asp Gly Pro Val Leu Leu Pro Asp Asn His Tyr 
    290                 295                 300                 


Leu Ser Thr Gln Ser Ala Leu Ser Lys Asp Pro Asn Glu Lys Arg Asp 
305                 310                 315                 320 


His Met Val Leu Leu Glu Phe Val Thr Ala Ala Gly Ile Thr His Gly 
                325                 330                 335     


Met Asp Glu Leu Tyr Lys Gly Gly His His His His His His 
            340                 345                 350 


<210>  10
<211>  348
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  polyhistidine-tagged INAD-GFP GIH fusion

<400>  10

Met Ala Ser Lys Gly Glu Glu Leu Phe Thr Gly Val Val Pro Ile Leu 
1               5                   10                  15      


Val Glu Leu Asp Gly Asp Val Asn Gly His Lys Phe Ser Val Ser Gly 
            20                  25                  30          


Glu Gly Glu Gly Asp Ala Thr Tyr Gly Lys Leu Thr Leu Lys Phe Ile 
        35                  40                  45              


Cys Thr Thr Gly Lys Leu Pro Val Pro Trp Pro Thr Leu Val Thr Thr 
    50                  55                  60                  


Phe Ser Tyr Gly Val Gln Cys Phe Ser Arg Tyr Pro Asp His Met Lys 
65                  70                  75                  80  


Arg His Asp Phe Phe Lys Ser Ala Met Pro Glu Gly Tyr Val Gln Glu 
                85                  90                  95      


Arg Thr Ile Ser Phe Lys Asp Asp Gly Asn Tyr Lys Thr Arg Ala Glu 
            100                 105                 110         


Val Lys Phe Glu Gly Asp Thr Leu Val Asn Arg Ile Glu Leu Lys Gly 
        115                 120                 125             


Ile Asp Phe Lys Glu Asp Gly Asn Ile Leu Gly His Lys Leu Glu Tyr 
    130                 135                 140                 


Asn Tyr Asn Ser His Asn Val Tyr Ile Thr Ala Asp Lys Gln Lys Asn 
145                 150                 155                 160 


Gly Ile Lys Ala Asn Phe Lys Ile Arg His Asn Ile Glu Asp Gly Ser 
                165                 170                 175     


Val Gln Leu Ala Asp His Tyr Gln Gln Asn Thr Pro Ile Gly Asp Gly 
            180                 185                 190         


Pro Val Leu Leu Pro Asp Asn His Tyr Leu Ser Thr Gln Ser Ala Leu 
        195                 200                 205             


Ser Lys Asp Pro Asn Glu Lys Arg Asp His Met Val Leu Leu Glu Phe 
    210                 215                 220                 


Val Thr Ala Ala Gly Ile Thr His Gly Met Asp Glu Leu Tyr Lys Gly 
225                 230                 235                 240 


Gly Ser Gly Ala Gly Glu Leu Ile His Met Val Thr Leu Asp Lys Thr 
                245                 250                 255     


Gly Lys Lys Ser Phe Gly Ile Cys Ile Val Arg Gly Glu Val Lys Asp 
            260                 265                 270         


Ser Pro Asn Thr Lys Thr Thr Gly Ile Phe Ile Lys Gly Ile Val Pro 
        275                 280                 285             


Asp Ser Pro Ala His Leu Cys Gly Arg Leu Lys Val Gly Asp Arg Ile 
    290                 295                 300                 


Leu Ser Leu Asn Gly Lys Asp Val Arg Asn Ser Thr Glu Gln Ala Val 
305                 310                 315                 320 


Ile Asp Leu Ile Lys Glu Ala Asp Phe Lys Ile Glu Leu Glu Ile Gln 
                325                 330                 335     


Thr Phe Asp Lys Gly Gly His His His His His His 
            340                 345             


