                              Sequence Listing

<110> GENENTECH, INC. et al.
      

<120> ZIRCONIUM-RADIOLABELED, CYSTEINE ENGINEERED ANTIBODY CONJUGATES

<130> P2066R1C1P1-WO

<140> 
<141>

<150> US 12/612,912
<151> 2009-11-05

<150> US 12/399,241
<151> 2009-03-06

<150> US 11/233,258
<151> 2005-09-22

<150> US 60/696,353
<151> 2005-06-30

<150> US 60/612,468
<151> 2004-09-23

<160> 49

<210> 1
<211> 30
<212> PRT
<213> Artificial sequence

<220>
<223> chemically synthesized

<400> 1
 Cys Asp Lys Thr His Thr Gly Gly Gly Ser Gln Arg Leu Met Glu
   1               5                  10                  15

 Asp Ile Cys Leu Pro Arg Trp Gly Cys Leu Trp Glu Asp Asp Phe
                  20                  25                  30

<210> 2
<211> 20
<212> PRT
<213> Artificial sequence

<220>
<223> chemically synthesized

<400> 2
 Gln Arg Leu Met Glu Asp Ile Cys Leu Pro Arg Trp Gly Cys Leu
   1               5                  10                  15

 Trp Glu Asp Asp Phe
                  20

<210> 3
<211> 20
<212> PRT
<213> Artificial sequence

<220>
<223> chemically synthesized

<400> 3
 Gln Arg Leu Ile Glu Asp Ile Cys Leu Pro Arg Trp Gly Cys Leu
   1               5                  10                  15

 Trp Glu Asp Asp Phe
                  20

<210> 4
<211> 18
<212> PRT
<213> Artificial sequence

<220>
<223> chemically synthesized

<400> 4
 Arg Leu Ile Glu Asp Ile Cys Leu Pro Arg Trp Gly Cys Leu Trp
   1               5                  10                  15

 Glu Asp Asp
            

<210> 5
<211> 11
<212> PRT
<213> Artificial sequence

<220>
<223> chemically synthesized

<400> 5
 Asp Ile Cys Leu Pro Arg Trp Gly Cys Leu Trp
                   5                  10    

<210> 6
<211> 450
<212> PRT
<213> Artificial sequence

<220>
<223> artificial protein

<400> 6
 Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly
   1               5                  10                  15

 Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Asn Ile Lys
                  20                  25                  30

 Asp Thr Tyr Ile His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu
                  35                  40                  45

 Glu Trp Val Ala Arg Ile Tyr Pro Thr Asn Gly Tyr Thr Arg Tyr
                  50                  55                  60

 Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Ala Asp Thr Ser
                  65                  70                  75

 Lys Asn Thr Ala Tyr Leu Gln Met Asn Ser Leu Arg Cys Glu Asp
                  80                  85                  90

 Thr Ala Val Tyr Tyr Cys Ser Arg Trp Gly Gly Asp Gly Phe Tyr
                  95                 100                 105

 Ala Met Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser
                 110                 115                 120

 Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser
                 125                 130                 135

 Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys
                 140                 145                 150

 Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala
                 155                 160                 165

 Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser
                 170                 175                 180

 Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser
                 185                 190                 195

 Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser
                 200                 205                 210

 Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys
                 215                 220                 225

 Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly
                 230                 235                 240

 Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met
                 245                 250                 255

 Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser
                 260                 265                 270

 His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val
                 275                 280                 285

 Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn
                 290                 295                 300

 Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp
                 305                 310                 315

 Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala
                 320                 325                 330

 Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln
                 335                 340                 345

 Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu
                 350                 355                 360

 Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe
                 365                 370                 375

 Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro
                 380                 385                 390

 Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly
                 395                 400                 405

 Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp
                 410                 415                 420

 Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu
                 425                 430                 435

 His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys
                 440                 445                 450

<210> 7
<211> 450
<212> PRT
<213> Artificial sequence

<220>
<223> chemically synthesized

<400> 7
 Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly
   1               5                  10                  15

 Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Asn Ile Lys
                  20                  25                  30

 Asp Thr Tyr Ile His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu
                  35                  40                  45

 Glu Trp Val Ala Arg Ile Tyr Pro Thr Asn Gly Tyr Thr Arg Tyr
                  50                  55                  60

 Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Ala Asp Thr Ser
                  65                  70                  75

 Lys Asn Thr Ala Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp
                  80                  85                  90

 Thr Ala Val Tyr Tyr Cys Ser Arg Trp Gly Gly Asp Gly Phe Tyr
                  95                 100                 105

 Ala Met Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser
                 110                 115                 120

 Cys Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser
                 125                 130                 135

 Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys
                 140                 145                 150

 Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala
                 155                 160                 165

 Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser
                 170                 175                 180

 Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser
                 185                 190                 195

 Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser
                 200                 205                 210

 Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys
                 215                 220                 225

 Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly
                 230                 235                 240

 Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met
                 245                 250                 255

 Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser
                 260                 265                 270

 His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val
                 275                 280                 285

 Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn
                 290                 295                 300

 Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp
                 305                 310                 315

 Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala
                 320                 325                 330

 Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln
                 335                 340                 345

 Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu
                 350                 355                 360

 Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe
                 365                 370                 375

 Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro
                 380                 385                 390

 Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly
                 395                 400                 405

 Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp
                 410                 415                 420

 Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu
                 425                 430                 435

 His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys
                 440                 445                 450

<210> 8
<211> 214
<212> PRT
<213> Artificial sequence

<220>
<223> chemically synthesized

<400> 8
 Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val
   1               5                  10                  15

 Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asp Val Asn
                  20                  25                  30

 Thr Ala Val Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys
                  35                  40                  45

 Leu Leu Ile Tyr Ser Ala Ser Phe Leu Tyr Ser Gly Val Pro Ser
                  50                  55                  60

 Arg Phe Ser Gly Ser Arg Ser Gly Thr Asp Phe Thr Leu Thr Ile
                  65                  70                  75

 Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln
                  80                  85                  90

 His Tyr Thr Thr Pro Pro Thr Phe Gly Gln Gly Thr Lys Val Glu
                  95                 100                 105

 Ile Lys Arg Thr Cys Ala Ala Pro Ser Val Phe Ile Phe Pro Pro
                 110                 115                 120

 Ser Asp Glu Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu
                 125                 130                 135

 Leu Asn Asn Phe Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val
                 140                 145                 150

 Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln Glu Ser Val Thr Glu
                 155                 160                 165

 Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser Ser Thr Leu Thr
                 170                 175                 180

 Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr Ala Cys Glu
                 185                 190                 195

 Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser Phe Asn
                 200                 205                 210

 Arg Gly Glu Cys
                

<210> 9
<211> 10
<212> PRT
<213> Artificial sequence

<220>
<223> chemically synthesized

<400> 9
 Trp Val Arg Gln Cys Pro Gly Lys Gly Leu
                   5                  10

<210> 10
<211> 10
<212> PRT
<213> Artificial sequence

<220>
<223> chemically synthesized

<400> 10
 Asn Ser Leu Arg Cys Glu Asp Thr Ala Val
                   5                  10

<210> 11
<211> 13
<212> PRT
<213> Artificial sequence

<220>
<223> chemically synthesized

<400> 11
 Leu Val Thr Val Cys Ser Ala Ser Thr Lys Gly Pro Ser
                   5                  10            

<210> 12
<211> 13
<212> PRT
<213> Artificial sequence

<220>
<223> chemically synthesized

<400> 12
 Leu Val Thr Val Ser Cys Ala Ser Thr Lys Gly Pro Ser
                   5                  10            

<210> 13
<211> 13
<212> PRT
<213> Artificial sequence

<220>
<223> chemically synthesized

<400> 13
 Leu Val Thr Val Ser Ser Cys Ser Thr Lys Gly Pro Ser
                   5                  10            

<210> 14
<211> 13
<212> PRT
<213> Artificial sequence

<220>
<223> chemically synthesized

<400> 14
 Leu Val Thr Val Ser Ser Ala Cys Thr Lys Gly Pro Ser
                   5                  10            

<210> 15
<211> 14
<212> PRT
<213> Artificial sequence

<220>
<223> chemically synthesized

<400> 15
 His Thr Phe Pro Cys Val Leu Gln Ser Ser Gly Leu Tyr Ser
                   5                  10                

<210> 16
<211> 14
<212> PRT
<213> Artificial sequence

<220>
<223> chemically synthesized

<400> 16
 His Thr Phe Pro Ala Val Leu Gln Cys Ser Gly Leu Tyr Ser
                   5                  10                

<210> 17
<211> 11
<212> PRT
<213> Artificial sequence

<220>
<223> chemically synthesized

<400> 17
 Ser Leu Ser Ala Ser Cys Gly Asp Arg Val Thr
                   5                  10    

<210> 18
<211> 11
<212> PRT
<213> Artificial sequence

<220>
<223> chemically synthesized

<400> 18
 Gln Lys Pro Gly Lys Cys Pro Lys Leu Leu Ile
                   5                  10    

<210> 19
<211> 11
<212> PRT
<213> Artificial sequence

<220>
<223> chemically synthesized

<400> 19
 Glu Ile Lys Arg Thr Cys Ala Ala Pro Ser Val
                   5                  10    

<210> 20
<211> 12
<212> PRT
<213> Artificial sequence

<220>
<223> chemically synthesized

<400> 20
 Thr Cys Ala Ala Pro Cys Val Phe Ile Phe Pro Pro
                   5                  10        

<210> 21
<211> 11
<212> PRT
<213> Artificial sequence

<220>
<223> chemically synthesized

<400> 21
 Phe Ile Phe Pro Pro Cys Asp Glu Gln Leu Lys
                   5                  10    

<210> 22
<211> 11
<212> PRT
<213> Artificial sequence

<220>
<223> chemically synthesized

<400> 22
 Asp Glu Gln Leu Lys Cys Gly Thr Ala Ser Val
                   5                  10    

<210> 23
<211> 11
<212> PRT
<213> Artificial sequence

<220>
<223> chemically synthesized

<400> 23
 Phe Tyr Pro Arg Glu Cys Lys Val Gln Trp Lys
                   5                  10    

<210> 24
<211> 11
<212> PRT
<213> Artificial sequence

<220>
<223> chemically synthesized

<400> 24
 Trp Lys Val Asp Asn Cys Leu Gln Ser Gly Asn
                   5                  10    

<210> 25
<211> 11
<212> PRT
<213> Artificial sequence

<220>
<223> chemically synthesized

<400> 25
 Ala Leu Gln Ser Gly Cys Ser Gln Glu Ser Val
                   5                  10    

<210> 26
<211> 11
<212> PRT
<213> Artificial sequence

<220>
<223> chemically synthesized

<400> 26
 Val Thr Glu Gln Asp Cys Lys Asp Ser Thr Tyr
                   5                  10    

<210> 27
<211> 11
<212> PRT
<213> Artificial sequence

<220>
<223> chemically synthesized

<400> 27
 Gly Leu Ser Ser Pro Cys Thr Lys Ser Phe Asn
                   5                  10    

<210> 28
<211> 450
<212> PRT
<213> Artificial sequence

<220>
<223> chemically synthesized

<400> 28
 Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly
   1               5                  10                  15

 Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Tyr Thr Phe Thr
                  20                  25                  30

 Ser Tyr Trp Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu
                  35                  40                  45

 Glu Trp Val Gly Phe Ile Asn Pro Ser Thr Gly Tyr Thr Asp Tyr
                  50                  55                  60

 Asn Gln Lys Phe Lys Asp Arg Phe Thr Ile Ser Ala Asp Thr Ser
                  65                  70                  75

 Lys Asn Thr Ala Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp
                  80                  85                  90

 Thr Ala Val Tyr Tyr Cys Thr Arg Arg Pro Lys Ile Pro Arg His
                  95                 100                 105

 Ala Asn Val Phe Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser
                 110                 115                 120

 Cys Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser
                 125                 130                 135

 Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys
                 140                 145                 150

 Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala
                 155                 160                 165

 Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser
                 170                 175                 180

 Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser
                 185                 190                 195

 Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser
                 200                 205                 210

 Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys
                 215                 220                 225

 Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly
                 230                 235                 240

 Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met
                 245                 250                 255

 Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser
                 260                 265                 270

 His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val
                 275                 280                 285

 Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn
                 290                 295                 300

 Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp
                 305                 310                 315

 Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala
                 320                 325                 330

 Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln
                 335                 340                 345

 Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu
                 350                 355                 360

 Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe
                 365                 370                 375

 Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro
                 380                 385                 390

 Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly
                 395                 400                 405

 Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp
                 410                 415                 420

 Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu
                 425                 430                 435

 His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys
                 440                 445                 450

<210> 29
<211> 25
<212> PRT
<213> Artificial sequence

<220>
<223> chemically synthesized

<400> 29
 His Glu Asp Pro Glu Cys Lys Phe Asn Trp Tyr Val Asp Gly Val
   1               5                  10                  15

 Glu Val His Asn Ala Lys Thr Lys Pro Arg
                  20                  25

<210> 30
<211> 25
<212> PRT
<213> Artificial sequence

<220>
<223> chemically synthesized

<400> 30
 His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Cys Asp Gly Val
   1               5                  10                  15

 Glu Val His Asn Ala Lys Thr Lys Pro Arg
                  20                  25

<210> 31
<211> 25
<212> PRT
<213> Artificial sequence

<220>
<223> chemically synthesized

<400> 31
 His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Cys
   1               5                  10                  15

 Glu Val His Asn Ala Lys Thr Lys Pro Arg
                  20                  25

<210> 32
<211> 25
<212> PRT
<213> Artificial sequence

<220>
<223> chemically synthesized

<400> 32
 His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val
   1               5                  10                  15

 Glu Cys His Asn Ala Lys Thr Lys Pro Arg
                  20                  25

<210> 33
<211> 25
<212> PRT
<213> Artificial sequence

<220>
<223> chemically synthesized

<400> 33
 His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val
   1               5                  10                  15

 Glu Val His Asn Cys Lys Thr Lys Pro Arg
                  20                  25

<210> 34
<211> 11
<212> PRT
<213> Artificial sequence

<220>
<223> chemically synthesized

<400> 34
 Tyr Lys Cys Lys Val Cys Asn Lys Ala Leu Pro
                   5                  10    

<210> 35
<211> 13
<212> PRT
<213> Artificial sequence

<220>
<223> artificial protein

<400> 35
 Ile Glu Lys Thr Ile Cys Lys Ala Lys Gly Gln Pro Arg
                   5                  10            

<210> 36
<211> 13
<212> PRT
<213> Artificial sequence

<220>
<223> chemically synthesized

<400> 36
 Ile Glu Lys Thr Ile Ser Lys Cys Lys Gly Gln Pro Arg
                   5                  10            

<210> 37
<211> 11
<212> PRT
<213> Artificial sequence

<220>
<223> chemically synthesized

<400> 37
 Lys Gly Phe Tyr Pro Cys Asp Ile Ala Val Glu
                   5                  10    

<210> 38
<211> 11
<212> PRT
<213> Artificial sequence

<220>
<223> chemically synthesized

<400> 38
 Pro Pro Val Leu Asp Cys Asp Gly Ser Phe Phe
                   5                  10    

<210> 39
<211> 446
<212> PRT
<213> Artificial sequence

<220>
<223> chemically synthesized

<400> 39
 Asp Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Asn Pro Ser
   1               5                  10                  15

 Gln Ser Leu Ser Leu Thr Cys Thr Val Thr Gly Tyr Ser Ile Thr
                  20                  25                  30

 Asn Asp Tyr Ala Trp Asn Trp Ile Arg Gln Phe Pro Gly Asn Lys
                  35                  40                  45

 Leu Glu Trp Met Gly Tyr Ile Asn Tyr Ser Gly Tyr Thr Thr Tyr
                  50                  55                  60

 Asn Pro Ser Leu Lys Ser Arg Ile Ser Ile Thr Arg Asp Thr Ser
                  65                  70                  75

 Lys Asn Gln Phe Phe Leu His Leu Asn Ser Val Thr Thr Glu Asp
                  80                  85                  90

 Thr Ala Thr Tyr Tyr Cys Ala Arg Trp Asp Gly Gly Leu Thr Tyr
                  95                 100                 105

 Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ala Cys Ser Thr Lys
                 110                 115                 120

 Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser
                 125                 130                 135

 Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro
                 140                 145                 150

 Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly
                 155                 160                 165

 Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser
                 170                 175                 180

 Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln
                 185                 190                 195

 Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val
                 200                 205                 210

 Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys
                 215                 220                 225

 Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe
                 230                 235                 240

 Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr
                 245                 250                 255

 Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro
                 260                 265                 270

 Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn
                 275                 280                 285

 Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg
                 290                 295                 300

 Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly
                 305                 310                 315

 Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro
                 320                 325                 330

 Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro
                 335                 340                 345

 Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn
                 350                 355                 360

 Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp
                 365                 370                 375

 Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr
                 380                 385                 390

 Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu
                 395                 400                 405

 Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn
                 410                 415                 420

 Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr
                 425                 430                 435

 Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys
                 440                 445    

<210> 40
<211> 10
<212> PRT
<213> Artificial sequence

<220>
<223> chemically synthesized

<400> 40
 Asn Trp Ile Arg Gln Cys Pro Gly Asn Lys
                   5                  10

<210> 41
<211> 11
<212> PRT
<213> Artificial sequence

<220>
<223> chemically synthesized

<400> 41
 Leu Asn Ser Cys Thr Thr Glu Asp Thr Ala Thr
                   5                  10    

<210> 42
<211> 21
<212> PRT
<213> Artificial sequence

<220>
<223> chemically synthesized

<400> 42
 Gly Gln Gly Thr Leu Val Thr Val Ser Ala Cys Ser Thr Lys Gly
   1               5                  10                  15

 Pro Ser Val Phe Pro Leu
                  20    

<210> 43
<211> 14
<212> PRT
<213> Artificial sequence

<220>
<223> chemically synthesized

<400> 43
 His Thr Phe Pro Cys Val Leu Gln Ser Ser Gly Leu Tyr Ser
                   5                  10                

<210> 44
<211> 14
<212> PRT
<213> Artificial sequence

<220>
<223> chemically synthesized

<400> 44
 His Thr Phe Pro Ala Cys Leu Gln Ser Ser Gly Leu Tyr Ser
                   5                  10                

<210> 45
<211> 11
<212> PRT
<213> Artificial sequence

<220>
<223> chemically synthesized

<400> 45
 Phe Leu Ser Val Ser Cys Gly Gly Arg Val Thr
                   5                  10    

<210> 46
<211> 11
<212> PRT
<213> Artificial sequence

<220>
<223> chemically synthesized

<400> 46
 Gln Lys Pro Gly Asn Cys Pro Arg Leu Leu Ile
                   5                  10    

<210> 47
<211> 11
<212> PRT
<213> Artificial sequence

<220>
<223> chemically synthesized

<400> 47
 Glu Ile Lys Arg Thr Cys Ala Ala Pro Ser Val
                   5                  10    

<210> 48
<211> 11
<212> PRT
<213> Artificial sequence

<220>
<223> artificial protein

<400> 48
 Phe Tyr Pro Arg Glu Cys Lys Val Gln Trp Lys
                   5                  10    

<210> 49
<211> 11
<212> PRT
<213> Artificial sequence

<220>
<223> chemically synthesized

<400> 49
 Val Thr Glu Gln Asp Cys Lys Asp Ser Thr Tyr
                   5                  10    

