                         SEQUENCE LISTING

<110>  The University of North Carolina at Chapel Hill
       Yeh, Jen Jen
 
<120>  METHODS AND COMPOSITIONS FOR PREDICTING SURVIVAL IN SUBJECTS WITH
        CANCER

<130>  421/260 PCT

<150>  US 61/280,470
<151>  2009-11-04

<160>  28    

<170>  PatentIn version 3.5

<210>  1
<211>  3776
<212>  DNA
<213>  Homo sapiens

<400>  1
cattcataag actcagagct acggccacgg cagggacacg cggaaccaag acttggaaac       60

ttgattgttg tggttcttct tgggggttat gaaatttcat taatcttttt ttttccgggg      120

agaaagtttt tggaaagatt cttccagata tttcttcatt ttcttttgga ggaccgactt      180

actttttttg gtcttcttta ttactcccct ccccccgtgg gacccgccgg acgcgtggag      240

gagaccgtag ctgaagctga ttctgtacag cgggacagcg ctttctgccc ctgggggagc      300

aacccctccc tcgcccctgg gtcctacgga gcctgcactt tcaagaggta cagcggcatc      360

ctgtgggggc ctgggcaccg caggaagact gcacagaaac tttgccattg ttggaacggg      420

acgttgctcc ttccccgagc ttccccggac agcgtacttt gaggactcgc tcagctcacc      480

ggggactccc acggctcacc ccggacttgc accttacttc cccaacccgg ccatagcctt      540

ggcttcccgg cgacctcagc gtggtcacag gggcccccct gtgcccaggg aaatgtttca      600

ggctttcccc ggagactacg actccggctc ccggtgcagc tcctcaccct ctgccgagtc      660

tcaatatctg tcttcggtgg actccttcgg cagtccaccc accgccgccg cctcccagga      720

gtgcgccggt ctcggggaaa tgcccggttc cttcgtgccc acggtcaccg cgatcacaac      780

cagccaggac ctccagtggc ttgtgcaacc caccctcatc tcttccatgg cccagtccca      840

ggggcagcca ctggcctccc agcccccggt cgtcgacccc tacgacatgc cgggaaccag      900

ctactccaca ccaggcatga gtggctacag cagtggcgga gcgagtggca gtggtgggcc      960

ttccaccagc ggaactacca gtgggcctgg gcctgcccgc ccagcccgag cccggcctag     1020

gagaccccga gaggagacgc tcaccccaga ggaagaggag aagcgaaggg tgcgccggga     1080

acgaaataaa ctagcagcag ctaaatgcag gaaccggcgg agggagctga ccgaccgact     1140

ccaggcggag acagatcagt tggaggaaga aaaagcagag ctggagtcgg agatcgccga     1200

gctccaaaag gagaaggaac gtctggagtt tgtgctggtg gcccacaaac cgggctgcaa     1260

gatcccctac gaagaggggc ccgggccggg cccgctggcg gaggtgagag atttgccggg     1320

ctcagcaccg gctaaggaag atggcttcag ctggctgctg ccgcccccgc caccaccgcc     1380

cctgcccttc cagaccagcc aagacgcacc ccccaacctg acggcttctc tctttacaca     1440

cagtgaagtt caagtcctcg gcgacccctt ccccgttgtt aacccttcgt acacttcttc     1500

gtttgtcctc acctgcccgg aggtctccgc gttcgccggc gcccaacgca ccagcggcag     1560

tgaccagcct tccgatcccc tgaactcgcc ctccctcctc gctctgtgaa ctctttagac     1620

acacaaaaca aacaaacaca tgggggagag agacttggaa gaggaggagg aggaggagaa     1680

ggaggagaga gaggggaaga gacaaagtgg gtgtgtggcc tccctggctc ctccgtctga     1740

ccctctgcgg ccactgcgcc actgccatcg gacaggagga ttccttgtgt tttgtcctgc     1800

ctcttgtttc tgtgccccgg cgaggccgga gagctggtga ctttggggac agggggtggg     1860

aaggggatgg acacccccag ctgactgttg gctctctgac gtcaacccaa gctctgggga     1920

tgggtgggga ggggggcggg tgacgcccac cttcgggcag tcctgtgtga ggattaaggg     1980

acgggggtgg gaggtaggct gtggggtggg ctggagtcct ctccagagag gctcaacaag     2040

gaaaaatgcc actccctacc caatgtctcc cacacccacc ctttttttgg ggtgcctagg     2100

ttggtttccc ctgcactccc gaccttagct tattgatccc acatttccat ggtgtgagat     2160

cctctttact ctgggcagaa gtgagccccc cccttaaagg gaattcgatg cccccctaga     2220

ataatctcat ccccccaccc gacttctttt gaaatgtgaa cgtccttcct tgactgtcta     2280

gccactccct cccagaaaaa ctggctctga ttggaatttc tggcctccta aggctcccca     2340

ccccgaaatc agcccccagc cttgtttctg atgacagtgt tatcccaaga ccctgccccc     2400

tgccagccga ccctcctggc cttcctcgtt gggccgctct gatttcaggc agcaggggct     2460

gctgtgatgc cgtcctgctg gagtgattta tactgtgaaa tgagttggcc agattgtggg     2520

gtgcagctgg gtggggcagc acacctctgg ggggataatg tccccactcc cgaaagcctt     2580

tcctcggtct cccttccgtc catccccctt cttcctcccc tcaacagtga gttagactca     2640

agggggtgac agaaccgaga agggggtgac agtcctccat ccacgtggcc tctctctctc     2700

tcctcaggac cctcagccct ggcctttttc tttaaggtcc cccgaccaat ccccagccta     2760

ggacgccaac ttctcccacc ccttggcccc tcacatcctc tccaggaagg gagtgagggg     2820

ctgtgacatt tttccggaga agatttcaga gctgaggctt tggtaccccc aaacccccaa     2880

tatttttgga ctggcagact caaggggctg gaatctcatg attccatgcc cgagtccgcc     2940

catccctgac catggttttg gctctcccac cccgccgttc cctgcgcttc atctcatgag     3000

gatttcttta tgaggcaaat ttatattttt taatatcggg gggtggacca cgccgccctc     3060

catccgtgct gcatgaaaaa cattccacgt gccccttgtc gcgcgtctcc catcctgatc     3120

ccagacccat tccttagcta tttatccctt tcctggtttc cgaaaggcaa ttatatctat     3180

tatgtataag taaatatatt atatatggat gtgtgtgtgt gcgtgcgcgt gagtgtgtga     3240

gcgcttctgc agcctcggcc taggtcacgt tggccctcaa agcgagccgt tgaattggaa     3300

actgcttcta gaaactctgg ctcagcctgt ctcgggctga cccttttctg atcgtctcgg     3360

cccctctgat tgttcccgat ggtctctctc cctctgtctt ttctcctccg cctgtgtcca     3420

tctgaccgtt ttcacttgtc tcctttctga ctgtccctgc caatgctcca gctgtcgtct     3480

gactctgggt tcgttgggga catgagattt tattttttgt gagtgagact gagggatcgt     3540

agatttttac aatctgtatc tttgacaatt ctgggtgcga gtgtgagagt gtgagcaggg     3600

cttgctcctg ccaaccacaa ttcaatgaat ccccgacccc cctaccccat gctgtacttg     3660

tggttctctt tttgtatttt gcatctgacc ccggggggct gggacagatt ggcaatgggc     3720

cgtcccctct ccccttggtt ctgcactgtt gccaataaaa agctcttaaa aacgca         3776


<210>  2
<211>  338
<212>  PRT
<213>  Homo sapiens

<400>  2

Met Phe Gln Ala Phe Pro Gly Asp Tyr Asp Ser Gly Ser Arg Cys Ser 
1               5                   10                  15      


Ser Ser Pro Ser Ala Glu Ser Gln Tyr Leu Ser Ser Val Asp Ser Phe 
            20                  25                  30          


Gly Ser Pro Pro Thr Ala Ala Ala Ser Gln Glu Cys Ala Gly Leu Gly 
        35                  40                  45              


Glu Met Pro Gly Ser Phe Val Pro Thr Val Thr Ala Ile Thr Thr Ser 
    50                  55                  60                  


Gln Asp Leu Gln Trp Leu Val Gln Pro Thr Leu Ile Ser Ser Met Ala 
65                  70                  75                  80  


Gln Ser Gln Gly Gln Pro Leu Ala Ser Gln Pro Pro Val Val Asp Pro 
                85                  90                  95      


Tyr Asp Met Pro Gly Thr Ser Tyr Ser Thr Pro Gly Met Ser Gly Tyr 
            100                 105                 110         


Ser Ser Gly Gly Ala Ser Gly Ser Gly Gly Pro Ser Thr Ser Gly Thr 
        115                 120                 125             


Thr Ser Gly Pro Gly Pro Ala Arg Pro Ala Arg Ala Arg Pro Arg Arg 
    130                 135                 140                 


Pro Arg Glu Glu Thr Leu Thr Pro Glu Glu Glu Glu Lys Arg Arg Val 
145                 150                 155                 160 


Arg Arg Glu Arg Asn Lys Leu Ala Ala Ala Lys Cys Arg Asn Arg Arg 
                165                 170                 175     


Arg Glu Leu Thr Asp Arg Leu Gln Ala Glu Thr Asp Gln Leu Glu Glu 
            180                 185                 190         


Glu Lys Ala Glu Leu Glu Ser Glu Ile Ala Glu Leu Gln Lys Glu Lys 
        195                 200                 205             


Glu Arg Leu Glu Phe Val Leu Val Ala His Lys Pro Gly Cys Lys Ile 
    210                 215                 220                 


Pro Tyr Glu Glu Gly Pro Gly Pro Gly Pro Leu Ala Glu Val Arg Asp 
225                 230                 235                 240 


Leu Pro Gly Ser Ala Pro Ala Lys Glu Asp Gly Phe Ser Trp Leu Leu 
                245                 250                 255     


Pro Pro Pro Pro Pro Pro Pro Leu Pro Phe Gln Thr Ser Gln Asp Ala 
            260                 265                 270         


Pro Pro Asn Leu Thr Ala Ser Leu Phe Thr His Ser Glu Val Gln Val 
        275                 280                 285             


Leu Gly Asp Pro Phe Pro Val Val Asn Pro Ser Tyr Thr Ser Ser Phe 
    290                 295                 300                 


Val Leu Thr Cys Pro Glu Val Ser Ala Phe Ala Gly Ala Gln Arg Thr 
305                 310                 315                 320 


Ser Gly Ser Asp Gln Pro Ser Asp Pro Leu Asn Ser Pro Ser Leu Leu 
                325                 330                 335     


Ala Leu 
        


<210>  3
<211>  3668
<212>  DNA
<213>  Homo sapiens

<400>  3
cattcataag actcagagct acggccacgg cagggacacg cggaaccaag acttggaaac       60

ttgattgttg tggttcttct tgggggttat gaaatttcat taatcttttt ttttccgggg      120

agaaagtttt tggaaagatt cttccagata tttcttcatt ttcttttgga ggaccgactt      180

actttttttg gtcttcttta ttactcccct ccccccgtgg gacccgccgg acgcgtggag      240

gagaccgtag ctgaagctga ttctgtacag cgggacagcg ctttctgccc ctgggggagc      300

aacccctccc tcgcccctgg gtcctacgga gcctgcactt tcaagaggta cagcggcatc      360

ctgtgggggc ctgggcaccg caggaagact gcacagaaac tttgccattg ttggaacggg      420

acgttgctcc ttccccgagc ttccccggac agcgtacttt gaggactcgc tcagctcacc      480

ggggactccc acggctcacc ccggacttgc accttacttc cccaacccgg ccatagcctt      540

ggcttcccgg cgacctcagc gtggtcacag gggcccccct gtgcccaggg aaatgtttca      600

ggctttcccc ggagactacg actccggctc ccggtgcagc tcctcaccct ctgccgagtc      660

tcaatatctg tcttcggtgg actccttcgg cagtccaccc accgccgccg cctcccagga      720

gtgcgccggt ctcggggaaa tgcccggttc cttcgtgccc acggtcaccg cgatcacaac      780

cagccaggac ctccagtggc ttgtgcaacc caccctcatc tcttccatgg cccagtccca      840

ggggcagcca ctggcctccc agcccccggt cgtcgacccc tacgacatgc cgggaaccag      900

ctactccaca ccaggcatga gtggctacag cagtggcgga gcgagtggca gtggtgggcc      960

ttccaccagc ggaactacca gtgggcctgg gcctgcccgc ccagcccgag cccggcctag     1020

gagaccccga gaggagacgg agacagatca gttggaggaa gaaaaagcag agctggagtc     1080

ggagatcgcc gagctccaaa aggagaagga acgtctggag tttgtgctgg tggcccacaa     1140

accgggctgc aagatcccct acgaagaggg gcccgggccg ggcccgctgg cggaggtgag     1200

agatttgccg ggctcagcac cggctaagga agatggcttc agctggctgc tgccgccccc     1260

gccaccaccg cccctgccct tccagaccag ccaagacgca ccccccaacc tgacggcttc     1320

tctctttaca cacagtgaag ttcaagtcct cggcgacccc ttccccgttg ttaacccttc     1380

gtacacttct tcgtttgtcc tcacctgccc ggaggtctcc gcgttcgccg gcgcccaacg     1440

caccagcggc agtgaccagc cttccgatcc cctgaactcg ccctccctcc tcgctctgtg     1500

aactctttag acacacaaaa caaacaaaca catgggggag agagacttgg aagaggagga     1560

ggaggaggag aaggaggaga gagaggggaa gagacaaagt gggtgtgtgg cctccctggc     1620

tcctccgtct gaccctctgc ggccactgcg ccactgccat cggacaggag gattccttgt     1680

gttttgtcct gcctcttgtt tctgtgcccc ggcgaggccg gagagctggt gactttgggg     1740

acagggggtg ggaaggggat ggacaccccc agctgactgt tggctctctg acgtcaaccc     1800

aagctctggg gatgggtggg gaggggggcg ggtgacgccc accttcgggc agtcctgtgt     1860

gaggattaag ggacgggggt gggaggtagg ctgtggggtg ggctggagtc ctctccagag     1920

aggctcaaca aggaaaaatg ccactcccta cccaatgtct cccacaccca cccttttttt     1980

ggggtgccta ggttggtttc ccctgcactc ccgaccttag cttattgatc ccacatttcc     2040

atggtgtgag atcctcttta ctctgggcag aagtgagccc cccccttaaa gggaattcga     2100

tgccccccta gaataatctc atccccccac ccgacttctt ttgaaatgtg aacgtccttc     2160

cttgactgtc tagccactcc ctcccagaaa aactggctct gattggaatt tctggcctcc     2220

taaggctccc caccccgaaa tcagccccca gccttgtttc tgatgacagt gttatcccaa     2280

gaccctgccc cctgccagcc gaccctcctg gccttcctcg ttgggccgct ctgatttcag     2340

gcagcagggg ctgctgtgat gccgtcctgc tggagtgatt tatactgtga aatgagttgg     2400

ccagattgtg gggtgcagct gggtggggca gcacacctct ggggggataa tgtccccact     2460

cccgaaagcc tttcctcggt ctcccttccg tccatccccc ttcttcctcc cctcaacagt     2520

gagttagact caagggggtg acagaaccga gaagggggtg acagtcctcc atccacgtgg     2580

cctctctctc tctcctcagg accctcagcc ctggcctttt tctttaaggt cccccgacca     2640

atccccagcc taggacgcca acttctccca ccccttggcc cctcacatcc tctccaggaa     2700

gggagtgagg ggctgtgaca tttttccgga gaagatttca gagctgaggc tttggtaccc     2760

ccaaaccccc aatatttttg gactggcaga ctcaaggggc tggaatctca tgattccatg     2820

cccgagtccg cccatccctg accatggttt tggctctccc accccgccgt tccctgcgct     2880

tcatctcatg aggatttctt tatgaggcaa atttatattt tttaatatcg gggggtggac     2940

cacgccgccc tccatccgtg ctgcatgaaa aacattccac gtgccccttg tcgcgcgtct     3000

cccatcctga tcccagaccc attccttagc tatttatccc tttcctggtt tccgaaaggc     3060

aattatatct attatgtata agtaaatata ttatatatgg atgtgtgtgt gtgcgtgcgc     3120

gtgagtgtgt gagcgcttct gcagcctcgg cctaggtcac gttggccctc aaagcgagcc     3180

gttgaattgg aaactgcttc tagaaactct ggctcagcct gtctcgggct gacccttttc     3240

tgatcgtctc ggcccctctg attgttcccg atggtctctc tccctctgtc ttttctcctc     3300

cgcctgtgtc catctgaccg ttttcacttg tctcctttct gactgtccct gccaatgctc     3360

cagctgtcgt ctgactctgg gttcgttggg gacatgagat tttatttttt gtgagtgaga     3420

ctgagggatc gtagattttt acaatctgta tctttgacaa ttctgggtgc gagtgtgaga     3480

gtgtgagcag ggcttgctcc tgccaaccac aattcaatga atccccgacc cccctacccc     3540

atgctgtact tgtggttctc tttttgtatt ttgcatctga ccccgggggg ctgggacaga     3600

ttggcaatgg gccgtcccct ctccccttgg ttctgcactg ttgccaataa aaagctctta     3660

aaaacgca                                                              3668


<210>  4
<211>  302
<212>  PRT
<213>  Homo sapiens

<400>  4

Met Phe Gln Ala Phe Pro Gly Asp Tyr Asp Ser Gly Ser Arg Cys Ser 
1               5                   10                  15      


Ser Ser Pro Ser Ala Glu Ser Gln Tyr Leu Ser Ser Val Asp Ser Phe 
            20                  25                  30          


Gly Ser Pro Pro Thr Ala Ala Ala Ser Gln Glu Cys Ala Gly Leu Gly 
        35                  40                  45              


Glu Met Pro Gly Ser Phe Val Pro Thr Val Thr Ala Ile Thr Thr Ser 
    50                  55                  60                  


Gln Asp Leu Gln Trp Leu Val Gln Pro Thr Leu Ile Ser Ser Met Ala 
65                  70                  75                  80  


Gln Ser Gln Gly Gln Pro Leu Ala Ser Gln Pro Pro Val Val Asp Pro 
                85                  90                  95      


Tyr Asp Met Pro Gly Thr Ser Tyr Ser Thr Pro Gly Met Ser Gly Tyr 
            100                 105                 110         


Ser Ser Gly Gly Ala Ser Gly Ser Gly Gly Pro Ser Thr Ser Gly Thr 
        115                 120                 125             


Thr Ser Gly Pro Gly Pro Ala Arg Pro Ala Arg Ala Arg Pro Arg Arg 
    130                 135                 140                 


Pro Arg Glu Glu Thr Glu Thr Asp Gln Leu Glu Glu Glu Lys Ala Glu 
145                 150                 155                 160 


Leu Glu Ser Glu Ile Ala Glu Leu Gln Lys Glu Lys Glu Arg Leu Glu 
                165                 170                 175     


Phe Val Leu Val Ala His Lys Pro Gly Cys Lys Ile Pro Tyr Glu Glu 
            180                 185                 190         


Gly Pro Gly Pro Gly Pro Leu Ala Glu Val Arg Asp Leu Pro Gly Ser 
        195                 200                 205             


Ala Pro Ala Lys Glu Asp Gly Phe Ser Trp Leu Leu Pro Pro Pro Pro 
    210                 215                 220                 


Pro Pro Pro Leu Pro Phe Gln Thr Ser Gln Asp Ala Pro Pro Asn Leu 
225                 230                 235                 240 


Thr Ala Ser Leu Phe Thr His Ser Glu Val Gln Val Leu Gly Asp Pro 
                245                 250                 255     


Phe Pro Val Val Asn Pro Ser Tyr Thr Ser Ser Phe Val Leu Thr Cys 
            260                 265                 270         


Pro Glu Val Ser Ala Phe Ala Gly Ala Gln Arg Thr Ser Gly Ser Asp 
        275                 280                 285             


Gln Pro Ser Asp Pro Leu Asn Ser Pro Ser Leu Leu Ala Leu 
    290                 295                 300         


<210>  5
<211>  4679
<212>  DNA
<213>  Homo sapiens

<400>  5
gagccaggcg ggggcggagg gggaggctgg cagcggagct ttgaataggg aagttttgca       60

ggggttacgt ttgcagtcag tccggtgttt gcaaatattg tgtgggctcc gcgcgctgcg      120

ggctgcggga gggtccggcc gggcgtctct gcgagcctgg agtttgcatg aaactttcac      180

ctgcgctccg gggagacttt cggctccggc tcccaccgcg cgcctcgccg ccctcgcgac      240

cgcgggctcc gtccaacccg gcccgacatg gacgtgctcc ccatgtgcag catcttccag      300

gagctccaga tcgtgcacga gaccggctac ttctcggcgc tgccgtctct ggaggagtac      360

tggcaacaga cctgcctaga gctggaacgt tacctccaga gcgagccctg ctatgtttca      420

gcctcagaaa tcaaatttga cagccaggaa gatctgtgga ccaaaatcat tctggctcgg      480

gagaaaaagg aggaatccga actgaagata tcttccagtc ctccagagga cactctcatc      540

agcccgagct tttgttacaa cttagagacc aacagcctga actcagatgt cagcagcgaa      600

tcctctgaca gctccgagga actttctccc acggccaagt ttacctccga ccccattggc      660

gaagttttgg tcagctcggg aaaattgagc tcctctgtca cctccacgcc tccatcttct      720

ccggaactga gcagggaacc ttctcaactg tggggttgcg tgcccgggga gctgccctcg      780

ccagggaagg tgcgcagcgg gacttcgggg aagccaggtg acaagggaaa tggcgatgcc      840

tcccccgacg gcaggaggag ggtgcaccgg tgccacttta acggctgcag gaaagtttac      900

accaaaagct cccacttgaa agcacaccag cggacgcaca caggagaaaa gccttacaga      960

tgctcatggg aagggtgtga gtggcgtttt gcaagaagtg atgagttaac caggcacttc     1020

cgaaagcaca ccggggccaa gccttttaaa tgctcccact gtgacaggtg tttttccagg     1080

tctgaccacc tggccctgca catgaagagg cacctctgag ggagcagaga ggtggatcct     1140

gtaggctaaa aggcttccag gctgagagcc ggccgtggaa ggagggatgc gtgttccagc     1200

caaagcatgc cgttctgcac cctacccagt tgcctccagg gcctctcctt ggaaggtctt     1260

ttgagggcta aaaaggtcct gtaagaagcg gcatagcacc cgtggtgcat ggtatgtggg     1320

tgaccctgga ctcgccactg gtacccgccc ttccgagcgg cgcctaagcc tttgccgtga     1380

gcatgcacac tgagaatgct aatggttggg ttgattgtat gttgaggatc tattactgac     1440

cgtatgatga ggccaacttt ttttccttgt ggttagcaag actgcaagag atggaaaaaa     1500

agtagtttga atgttttgtg tgtaaggagt ataccatgag atgagatgac caccaatcat     1560

ttccttgggg ggagggggtg tctgcacctt agaaaaaaaa agaaaaatca aaaaaacaaa     1620

aaaacaaaaa caaaaaaaga aggaaaatct tggagggtgg gcgtgggaac tcaggacccc     1680

agagtggcga gtggtgtggg gagggagagc ctctctcccc cttttctgtg tgagaggaac     1740

tcttagtgtc tggtgcagct attaaatgtg caatgtgtca agtagcttgt tttacacgct     1800

acaacatagc tcatttgtaa cccattgtat aagctgtgta tttacaaata taacacaaca     1860

atttaacttt tccttagaat acaaaaagtc atgcatggtc tggggaacta tatgcttttc     1920

catttttaag tcaggactgc aatactgatt ccagttaatg agcagctaag atccaatctg     1980

tctaatacag tgacccccta gccatccggg cctggcaata tacaattttt tttcccctcc     2040

aagtttgtaa cactcccctt ccagaaaggc attgtgcaac acaggattat ttttaaatga     2100

ttctgaattt gaattaactt tttggagaat tctgtgatgc ccttagaaga aattggacac     2160

gtattgagtg tcacaaagct ggggctggga attgctggtc taatgtttca ttagacttaa     2220

gaacctaaaa tttttctcag ttgggtggat aaaaccacta acgcttagaa actgttttct     2280

catgcagcta tgtttctctt atttatgcct tgaggactaa tttctggttt tctagctgtt     2340

aatgcactgt tgaccttcat aatggtgcct tacgcaagcg atcccttctg tgggggtctc     2400

atacaggggt gtgggcgatg catgctttat taaggctctt gtttcacctg gcagtgtact     2460

gtatcaacgt ataatacaga aaaaaaatct ctttaaggtc ctccttcaca aagacataga     2520

gtgaaactcc ctttacatgt cagtatttgt tcaacacttt aggcaacttg actgtcagtg     2580

ttaaaatgga aaacaggaaa atggaaaaat ctgaccaatt ctgccacctt gagactttca     2640

tatagacctt gcacaacaat tgtatagatc acacaccggc tgtatttaat atgtaacatt     2700

ttcacacata ttaaagatac agaagtatta aaaaaccccc aatgttaatg tatttgctta     2760

aaaggcacaa gtttcacata tctgtctagc tatctgttgg taatacagaa agtatactac     2820

ttttttaaaa aagtgggcag aattcttgtg tatgtatatt tgtgtgtaca gtatgtgtat     2880

gtgtgtatat atatatatta tatatataga taatatataa atattttttt taaggagaaa     2940

ctagaatgtt tagctagaaa attccacagc ctgtgaagaa atatttcaaa atggccataa     3000

aggaggtaaa aatgaaaacc ataacctaac ttttatagag gctttatctt taatttaacg     3060

atgtgcggag gactttcttg cttgaatctg ttccgggctg tctgctctgt ccatcaaatg     3120

ggcaggtctg gaatggggca ccttcggccg ttcagaagtg gcctgaacag aatgctggaa     3180

cccaggctgg actcggacac actaaggttt tgattttgaa tttcagcctt attagaagat     3240

ctaacctaag agtaagctaa ccacagggat tcttttgtag aacacttttt atgcagatga     3300

agctattttt tccagcaagt agattcttcc agtttttcca aggagtaatt tccccgaatt     3360

ggcataccac ggcgtggaca gctgatattt cacccagctg ctggcttgtg ggtgtggctc     3420

tttgctttat atatatatac acacatgtga gtctggctgg gctggtattt tgtttgatct     3480

tcctggaaat gagcagtgac taacgctcac ataactggtt ttttttttat ctgggctgat     3540

gaatacattt acctaagaaa ctcatttcgt tttacttaag aggggaagtg cagttttctt     3600

ttggcagttc agaatccaag cacttgattt gctgggtttg gaaaactcct tttttggcct     3660

tctatgtgct tagccataac aattccatta agcaagaagg taagcaaaag acaaaaaaaa     3720

aaaaaggaaa aaaaaaaact tgcactggct tgtctcactt acgaaacatg tcggagctgt     3780

ttgcctgggt ggggctgggt accgtacctg tcaatgcctg tgattttcat aattagcacg     3840

tacataaaga agtacattct gttcaggtga taactgagcc tcaatcaagc agaaactttt     3900

tgcttgaaat taaaaaaaaa tttctattag tgaaatttct tttttttttt tttttggaag     3960

caccctgtta tctaaagaat ctttgtaaga tttttgtaaa attttgtttt acaagatttt     4020

atttgaaatt gttttttgca agattgttat atttctgtat gaatgtattt tttattggaa     4080

taacataaaa gaattcttat cagcatcttg agtctggttg ttttttttgg gggaaggggg     4140

ttgttggaac agattcctcc tgcattcatc accctggctt cctcctgggg gcaaatcttc     4200

attgagcaac cctgagaaca actcaccgac ctcagcccct tcctctttcc acagcctgtc     4260

ctgggagctg gagaggatgt cagcgagcct gacattgccc tccctgaatg catcaaatac     4320

tcttctccaa ggactgacaa aaacaacccc ccggctgtgg gcacagtagg gaaccatgcc     4380

ggtttgatct tccattgctc aagccaggga atgcattgca gaggcacctg cacaacgaca     4440

aacttgagtg tttccctgcc acttctgtgc ctccacagcc tgctccagtt ccgcagctag     4500

agctgggcct accttcccca gccagccctg ccacacacct ggctgaggca tgtctgggag     4560

gggtggagga ggcagaggga ctccaggcca gagggctgtt ctcacaacct cagcccactc     4620

tcagtcaagg agggcagaaa ataaaagatg acatcactgc caaaaaaaaa aaaaaaaaa      4679


<210>  6
<211>  283
<212>  PRT
<213>  Homo sapiens

<400>  6

Met Asp Val Leu Pro Met Cys Ser Ile Phe Gln Glu Leu Gln Ile Val 
1               5                   10                  15      


His Glu Thr Gly Tyr Phe Ser Ala Leu Pro Ser Leu Glu Glu Tyr Trp 
            20                  25                  30          


Gln Gln Thr Cys Leu Glu Leu Glu Arg Tyr Leu Gln Ser Glu Pro Cys 
        35                  40                  45              


Tyr Val Ser Ala Ser Glu Ile Lys Phe Asp Ser Gln Glu Asp Leu Trp 
    50                  55                  60                  


Thr Lys Ile Ile Leu Ala Arg Glu Lys Lys Glu Glu Ser Glu Leu Lys 
65                  70                  75                  80  


Ile Ser Ser Ser Pro Pro Glu Asp Thr Leu Ile Ser Pro Ser Phe Cys 
                85                  90                  95      


Tyr Asn Leu Glu Thr Asn Ser Leu Asn Ser Asp Val Ser Ser Glu Ser 
            100                 105                 110         


Ser Asp Ser Ser Glu Glu Leu Ser Pro Thr Ala Lys Phe Thr Ser Asp 
        115                 120                 125             


Pro Ile Gly Glu Val Leu Val Ser Ser Gly Lys Leu Ser Ser Ser Val 
    130                 135                 140                 


Thr Ser Thr Pro Pro Ser Ser Pro Glu Leu Ser Arg Glu Pro Ser Gln 
145                 150                 155                 160 


Leu Trp Gly Cys Val Pro Gly Glu Leu Pro Ser Pro Gly Lys Val Arg 
                165                 170                 175     


Ser Gly Thr Ser Gly Lys Pro Gly Asp Lys Gly Asn Gly Asp Ala Ser 
            180                 185                 190         


Pro Asp Gly Arg Arg Arg Val His Arg Cys His Phe Asn Gly Cys Arg 
        195                 200                 205             


Lys Val Tyr Thr Lys Ser Ser His Leu Lys Ala His Gln Arg Thr His 
    210                 215                 220                 


Thr Gly Glu Lys Pro Tyr Arg Cys Ser Trp Glu Gly Cys Glu Trp Arg 
225                 230                 235                 240 


Phe Ala Arg Ser Asp Glu Leu Thr Arg His Phe Arg Lys His Thr Gly 
                245                 250                 255     


Ala Lys Pro Phe Lys Cys Ser His Cys Asp Arg Cys Phe Ser Arg Ser 
            260                 265                 270         


Asp His Leu Ala Leu His Met Lys Arg His Leu 
        275                 280             


<210>  7
<211>  4553
<212>  DNA
<213>  Homo sapiens

<400>  7
gagccaggcg ggggcggagg gggaggctgg cagcggagct ttgaataggg aagttttgca       60

ggggttacgt ttgcagtcag tccggtgttt gcaaatattg tgtgggctcc gcgcgctgcg      120

ggctgcggga gggtccggcc gggcgtctct gcgagcctgg agtttgcatg aaactttcac      180

ctgcgctccg gggagacttt cggctccggc tcccaccgcg cgcctcgccg ccctcgcgac      240

cgcgggctcc gtccaacccg gcccgacatg gacgtgctcc ccatgtgcag catcttccag      300

gagctccaga tcgtgcacga gaccggctac ttctcggcgc tgccgtctct ggaggagtac      360

tggcaacaga cctgcctaga gctggaacgt tacctccaga gcgagccctg ctatgtttca      420

gcctcagaaa tcaaatttga cagccaggaa gatctgtgga ccaaaatcat tctggctcgg      480

gagaaaaagg aggaatccga actgaagata tcttccagtc ctccagagga cactctcatc      540

agcccgagct tttgttacaa cttagagacc aacagcctga actcagatgt cagcagcgaa      600

tcctctgaca gctccgagga actttctccc acggccaagt ttacctccga ccccattggc      660

gaagttttgg tcagctcggg aaaattgagc tcctctgtca cctccacgcc tccatcttct      720

ccggaactga gcagggaacc ttctcaactg tggggttgcg tgcccgggga gctgccctcg      780

ccagggaagg tgcgcagcgg gacttcgggg aagccaggag aaaagcctta cagatgctca      840

tgggaagggt gtgagtggcg ttttgcaaga agtgatgagt taaccaggca cttccgaaag      900

cacaccgggg ccaagccttt taaatgctcc cactgtgaca ggtgtttttc caggtctgac      960

cacctggccc tgcacatgaa gaggcacctc tgagggagca gagaggtgga tcctgtaggc     1020

taaaaggctt ccaggctgag agccggccgt ggaaggaggg atgcgtgttc cagccaaagc     1080

atgccgttct gcaccctacc cagttgcctc cagggcctct ccttggaagg tcttttgagg     1140

gctaaaaagg tcctgtaaga agcggcatag cacccgtggt gcatggtatg tgggtgaccc     1200

tggactcgcc actggtaccc gcccttccga gcggcgccta agcctttgcc gtgagcatgc     1260

acactgagaa tgctaatggt tgggttgatt gtatgttgag gatctattac tgaccgtatg     1320

atgaggccaa ctttttttcc ttgtggttag caagactgca agagatggaa aaaaagtagt     1380

ttgaatgttt tgtgtgtaag gagtatacca tgagatgaga tgaccaccaa tcatttcctt     1440

ggggggaggg ggtgtctgca ccttagaaaa aaaaagaaaa atcaaaaaaa caaaaaaaca     1500

aaaacaaaaa aagaaggaaa atcttggagg gtgggcgtgg gaactcagga ccccagagtg     1560

gcgagtggtg tggggaggga gagcctctct cccccttttc tgtgtgagag gaactcttag     1620

tgtctggtgc agctattaaa tgtgcaatgt gtcaagtagc ttgttttaca cgctacaaca     1680

tagctcattt gtaacccatt gtataagctg tgtatttaca aatataacac aacaatttaa     1740

cttttcctta gaatacaaaa agtcatgcat ggtctgggga actatatgct tttccatttt     1800

taagtcagga ctgcaatact gattccagtt aatgagcagc taagatccaa tctgtctaat     1860

acagtgaccc cctagccatc cgggcctggc aatatacaat tttttttccc ctccaagttt     1920

gtaacactcc ccttccagaa aggcattgtg caacacagga ttatttttaa atgattctga     1980

atttgaatta actttttgga gaattctgtg atgcccttag aagaaattgg acacgtattg     2040

agtgtcacaa agctggggct gggaattgct ggtctaatgt ttcattagac ttaagaacct     2100

aaaatttttc tcagttgggt ggataaaacc actaacgctt agaaactgtt ttctcatgca     2160

gctatgtttc tcttatttat gccttgagga ctaatttctg gttttctagc tgttaatgca     2220

ctgttgacct tcataatggt gccttacgca agcgatccct tctgtggggg tctcatacag     2280

gggtgtgggc gatgcatgct ttattaaggc tcttgtttca cctggcagtg tactgtatca     2340

acgtataata cagaaaaaaa atctctttaa ggtcctcctt cacaaagaca tagagtgaaa     2400

ctccctttac atgtcagtat ttgttcaaca ctttaggcaa cttgactgtc agtgttaaaa     2460

tggaaaacag gaaaatggaa aaatctgacc aattctgcca ccttgagact ttcatataga     2520

ccttgcacaa caattgtata gatcacacac cggctgtatt taatatgtaa cattttcaca     2580

catattaaag atacagaagt attaaaaaac ccccaatgtt aatgtatttg cttaaaaggc     2640

acaagtttca catatctgtc tagctatctg ttggtaatac agaaagtata ctactttttt     2700

aaaaaagtgg gcagaattct tgtgtatgta tatttgtgtg tacagtatgt gtatgtgtgt     2760

atatatatat attatatata tagataatat ataaatattt tttttaagga gaaactagaa     2820

tgtttagcta gaaaattcca cagcctgtga agaaatattt caaaatggcc ataaaggagg     2880

taaaaatgaa aaccataacc taacttttat agaggcttta tctttaattt aacgatgtgc     2940

ggaggacttt cttgcttgaa tctgttccgg gctgtctgct ctgtccatca aatgggcagg     3000

tctggaatgg ggcaccttcg gccgttcaga agtggcctga acagaatgct ggaacccagg     3060

ctggactcgg acacactaag gttttgattt tgaatttcag ccttattaga agatctaacc     3120

taagagtaag ctaaccacag ggattctttt gtagaacact ttttatgcag atgaagctat     3180

tttttccagc aagtagattc ttccagtttt tccaaggagt aatttccccg aattggcata     3240

ccacggcgtg gacagctgat atttcaccca gctgctggct tgtgggtgtg gctctttgct     3300

ttatatatat atacacacat gtgagtctgg ctgggctggt attttgtttg atcttcctgg     3360

aaatgagcag tgactaacgc tcacataact ggtttttttt ttatctgggc tgatgaatac     3420

atttacctaa gaaactcatt tcgttttact taagagggga agtgcagttt tcttttggca     3480

gttcagaatc caagcacttg atttgctggg tttggaaaac tccttttttg gccttctatg     3540

tgcttagcca taacaattcc attaagcaag aaggtaagca aaagacaaaa aaaaaaaaag     3600

gaaaaaaaaa aacttgcact ggcttgtctc acttacgaaa catgtcggag ctgtttgcct     3660

gggtggggct gggtaccgta cctgtcaatg cctgtgattt tcataattag cacgtacata     3720

aagaagtaca ttctgttcag gtgataactg agcctcaatc aagcagaaac tttttgcttg     3780

aaattaaaaa aaaatttcta ttagtgaaat ttcttttttt tttttttttg gaagcaccct     3840

gttatctaaa gaatctttgt aagatttttg taaaattttg ttttacaaga ttttatttga     3900

aattgttttt tgcaagattg ttatatttct gtatgaatgt attttttatt ggaataacat     3960

aaaagaattc ttatcagcat cttgagtctg gttgtttttt ttgggggaag ggggttgttg     4020

gaacagattc ctcctgcatt catcaccctg gcttcctcct gggggcaaat cttcattgag     4080

caaccctgag aacaactcac cgacctcagc cccttcctct ttccacagcc tgtcctggga     4140

gctggagagg atgtcagcga gcctgacatt gccctccctg aatgcatcaa atactcttct     4200

ccaaggactg acaaaaacaa ccccccggct gtgggcacag tagggaacca tgccggtttg     4260

atcttccatt gctcaagcca gggaatgcat tgcagaggca cctgcacaac gacaaacttg     4320

agtgtttccc tgccacttct gtgcctccac agcctgctcc agttccgcag ctagagctgg     4380

gcctaccttc cccagccagc cctgccacac acctggctga ggcatgtctg ggaggggtgg     4440

aggaggcaga gggactccag gccagagggc tgttctcaca acctcagccc actctcagtc     4500

aaggagggca gaaaataaaa gatgacatca ctgccaaaaa aaaaaaaaaa aaa            4553


<210>  8
<211>  241
<212>  PRT
<213>  Homo sapiens

<400>  8

Met Asp Val Leu Pro Met Cys Ser Ile Phe Gln Glu Leu Gln Ile Val 
1               5                   10                  15      


His Glu Thr Gly Tyr Phe Ser Ala Leu Pro Ser Leu Glu Glu Tyr Trp 
            20                  25                  30          


Gln Gln Thr Cys Leu Glu Leu Glu Arg Tyr Leu Gln Ser Glu Pro Cys 
        35                  40                  45              


Tyr Val Ser Ala Ser Glu Ile Lys Phe Asp Ser Gln Glu Asp Leu Trp 
    50                  55                  60                  


Thr Lys Ile Ile Leu Ala Arg Glu Lys Lys Glu Glu Ser Glu Leu Lys 
65                  70                  75                  80  


Ile Ser Ser Ser Pro Pro Glu Asp Thr Leu Ile Ser Pro Ser Phe Cys 
                85                  90                  95      


Tyr Asn Leu Glu Thr Asn Ser Leu Asn Ser Asp Val Ser Ser Glu Ser 
            100                 105                 110         


Ser Asp Ser Ser Glu Glu Leu Ser Pro Thr Ala Lys Phe Thr Ser Asp 
        115                 120                 125             


Pro Ile Gly Glu Val Leu Val Ser Ser Gly Lys Leu Ser Ser Ser Val 
    130                 135                 140                 


Thr Ser Thr Pro Pro Ser Ser Pro Glu Leu Ser Arg Glu Pro Ser Gln 
145                 150                 155                 160 


Leu Trp Gly Cys Val Pro Gly Glu Leu Pro Ser Pro Gly Lys Val Arg 
                165                 170                 175     


Ser Gly Thr Ser Gly Lys Pro Gly Glu Lys Pro Tyr Arg Cys Ser Trp 
            180                 185                 190         


Glu Gly Cys Glu Trp Arg Phe Ala Arg Ser Asp Glu Leu Thr Arg His 
        195                 200                 205             


Phe Arg Lys His Thr Gly Ala Lys Pro Phe Lys Cys Ser His Cys Asp 
    210                 215                 220                 


Arg Cys Phe Ser Arg Ser Asp His Leu Ala Leu His Met Lys Arg His 
225                 230                 235                 240 


Leu 
    


<210>  9
<211>  4555
<212>  DNA
<213>  Homo sapiens

<400>  9
gagccaggcg ggggcggagg gggaggctgg cagcggagct ttgaataggg aagttttgca       60

ggggttacgt ttgcagtcag tccggtgttt gcaaatattg tgtgggctcc gcgcgctgcg      120

ggctgcggga gggtccggcc gggcgtctct gcgagcctgg agtttgcatg aaactttcac      180

ctgcgctccg gggagacttt cggctccggc tcccaccgcg cgcctcgccg ccctcgcgac      240

cgcgggctcc gtccaacccg gcccgacatg gacgtgctcc ccatgtgcag catcttccag      300

gagctccaga tcgtgcacga gaccggctac ttctcggcgc tgccgtctct ggaggagtac      360

tggcaacaga cctgcctaga gctggaacgt tacctccaga gcgagccctg ctatgtttca      420

gcctcagaaa tcaaatttga cagccaggaa gatctgtgga ccaaaatcat tctggctcgg      480

gagaaaaagg aggaatccga actgaagata tcttccagtc ctccagagga cactctcatc      540

agcccgagct tttgttacaa cttagagacc aacagcctga actcagatgt cagcagcgaa      600

tcctctgaca gctccgagga actttctccc acggccaagt ttacctccga ccccattggc      660

gaagttttgg tcagctcggg aaaattgagc tcctctgtca cctccacgcc tccatcttct      720

ccggaactga gcagggaacc ttctcaactg tggggttgcg tgcccgggga gctgccctcg      780

ccagggaagg tgcgcagcgg gacttcgggg aagccaggtg acaagggaaa tggcgatgcc      840

tcccccgacg gcaggaggag ggtgcaccgg tgccacttta acggctgcag gaaagtttac      900

accaaaagct cccacttgaa agcacaccag cggacgcaca caggtgtttt tccaggtctg      960

accacctggc cctgcacatg aagaggcacc tctgagggag cagagaggtg gatcctgtag     1020

gctaaaaggc ttccaggctg agagccggcc gtggaaggag ggatgcgtgt tccagccaaa     1080

gcatgccgtt ctgcacccta cccagttgcc tccagggcct ctccttggaa ggtcttttga     1140

gggctaaaaa ggtcctgtaa gaagcggcat agcacccgtg gtgcatggta tgtgggtgac     1200

cctggactcg ccactggtac ccgcccttcc gagcggcgcc taagcctttg ccgtgagcat     1260

gcacactgag aatgctaatg gttgggttga ttgtatgttg aggatctatt actgaccgta     1320

tgatgaggcc aacttttttt ccttgtggtt agcaagactg caagagatgg aaaaaaagta     1380

gtttgaatgt tttgtgtgta aggagtatac catgagatga gatgaccacc aatcatttcc     1440

ttggggggag ggggtgtctg caccttagaa aaaaaaagaa aaatcaaaaa aacaaaaaaa     1500

caaaaacaaa aaaagaagga aaatcttgga gggtgggcgt gggaactcag gaccccagag     1560

tggcgagtgg tgtggggagg gagagcctct ctcccccttt tctgtgtgag aggaactctt     1620

agtgtctggt gcagctatta aatgtgcaat gtgtcaagta gcttgtttta cacgctacaa     1680

catagctcat ttgtaaccca ttgtataagc tgtgtattta caaatataac acaacaattt     1740

aacttttcct tagaatacaa aaagtcatgc atggtctggg gaactatatg cttttccatt     1800

tttaagtcag gactgcaata ctgattccag ttaatgagca gctaagatcc aatctgtcta     1860

atacagtgac cccctagcca tccgggcctg gcaatataca attttttttc ccctccaagt     1920

ttgtaacact ccccttccag aaaggcattg tgcaacacag gattattttt aaatgattct     1980

gaatttgaat taactttttg gagaattctg tgatgccctt agaagaaatt ggacacgtat     2040

tgagtgtcac aaagctgggg ctgggaattg ctggtctaat gtttcattag acttaagaac     2100

ctaaaatttt tctcagttgg gtggataaaa ccactaacgc ttagaaactg ttttctcatg     2160

cagctatgtt tctcttattt atgccttgag gactaatttc tggttttcta gctgttaatg     2220

cactgttgac cttcataatg gtgccttacg caagcgatcc cttctgtggg ggtctcatac     2280

aggggtgtgg gcgatgcatg ctttattaag gctcttgttt cacctggcag tgtactgtat     2340

caacgtataa tacagaaaaa aaatctcttt aaggtcctcc ttcacaaaga catagagtga     2400

aactcccttt acatgtcagt atttgttcaa cactttaggc aacttgactg tcagtgttaa     2460

aatggaaaac aggaaaatgg aaaaatctga ccaattctgc caccttgaga ctttcatata     2520

gaccttgcac aacaattgta tagatcacac accggctgta tttaatatgt aacattttca     2580

cacatattaa agatacagaa gtattaaaaa acccccaatg ttaatgtatt tgcttaaaag     2640

gcacaagttt cacatatctg tctagctatc tgttggtaat acagaaagta tactactttt     2700

ttaaaaaagt gggcagaatt cttgtgtatg tatatttgtg tgtacagtat gtgtatgtgt     2760

gtatatatat atattatata tatagataat atataaatat tttttttaag gagaaactag     2820

aatgtttagc tagaaaattc cacagcctgt gaagaaatat ttcaaaatgg ccataaagga     2880

ggtaaaaatg aaaaccataa cctaactttt atagaggctt tatctttaat ttaacgatgt     2940

gcggaggact ttcttgcttg aatctgttcc gggctgtctg ctctgtccat caaatgggca     3000

ggtctggaat ggggcacctt cggccgttca gaagtggcct gaacagaatg ctggaaccca     3060

ggctggactc ggacacacta aggttttgat tttgaatttc agccttatta gaagatctaa     3120

cctaagagta agctaaccac agggattctt ttgtagaaca ctttttatgc agatgaagct     3180

attttttcca gcaagtagat tcttccagtt tttccaagga gtaatttccc cgaattggca     3240

taccacggcg tggacagctg atatttcacc cagctgctgg cttgtgggtg tggctctttg     3300

ctttatatat atatacacac atgtgagtct ggctgggctg gtattttgtt tgatcttcct     3360

ggaaatgagc agtgactaac gctcacataa ctggtttttt ttttatctgg gctgatgaat     3420

acatttacct aagaaactca tttcgtttta cttaagaggg gaagtgcagt tttcttttgg     3480

cagttcagaa tccaagcact tgatttgctg ggtttggaaa actccttttt tggccttcta     3540

tgtgcttagc cataacaatt ccattaagca agaaggtaag caaaagacaa aaaaaaaaaa     3600

aggaaaaaaa aaaacttgca ctggcttgtc tcacttacga aacatgtcgg agctgtttgc     3660

ctgggtgggg ctgggtaccg tacctgtcaa tgcctgtgat tttcataatt agcacgtaca     3720

taaagaagta cattctgttc aggtgataac tgagcctcaa tcaagcagaa actttttgct     3780

tgaaattaaa aaaaaatttc tattagtgaa atttcttttt tttttttttt tggaagcacc     3840

ctgttatcta aagaatcttt gtaagatttt tgtaaaattt tgttttacaa gattttattt     3900

gaaattgttt tttgcaagat tgttatattt ctgtatgaat gtatttttta ttggaataac     3960

ataaaagaat tcttatcagc atcttgagtc tggttgtttt ttttggggga agggggttgt     4020

tggaacagat tcctcctgca ttcatcaccc tggcttcctc ctgggggcaa atcttcattg     4080

agcaaccctg agaacaactc accgacctca gccccttcct ctttccacag cctgtcctgg     4140

gagctggaga ggatgtcagc gagcctgaca ttgccctccc tgaatgcatc aaatactctt     4200

ctccaaggac tgacaaaaac aaccccccgg ctgtgggcac agtagggaac catgccggtt     4260

tgatcttcca ttgctcaagc cagggaatgc attgcagagg cacctgcaca acgacaaact     4320

tgagtgtttc cctgccactt ctgtgcctcc acagcctgct ccagttccgc agctagagct     4380

gggcctacct tccccagcca gccctgccac acacctggct gaggcatgtc tgggaggggt     4440

ggaggaggca gagggactcc aggccagagg gctgttctca caacctcagc ccactctcag     4500

tcaaggaggg cagaaaataa aagatgacat cactgccaaa aaaaaaaaaa aaaaa          4555


<210>  10
<211>  237
<212>  PRT
<213>  Homo sapiens

<400>  10

Met Asp Val Leu Pro Met Cys Ser Ile Phe Gln Glu Leu Gln Ile Val 
1               5                   10                  15      


His Glu Thr Gly Tyr Phe Ser Ala Leu Pro Ser Leu Glu Glu Tyr Trp 
            20                  25                  30          


Gln Gln Thr Cys Leu Glu Leu Glu Arg Tyr Leu Gln Ser Glu Pro Cys 
        35                  40                  45              


Tyr Val Ser Ala Ser Glu Ile Lys Phe Asp Ser Gln Glu Asp Leu Trp 
    50                  55                  60                  


Thr Lys Ile Ile Leu Ala Arg Glu Lys Lys Glu Glu Ser Glu Leu Lys 
65                  70                  75                  80  


Ile Ser Ser Ser Pro Pro Glu Asp Thr Leu Ile Ser Pro Ser Phe Cys 
                85                  90                  95      


Tyr Asn Leu Glu Thr Asn Ser Leu Asn Ser Asp Val Ser Ser Glu Ser 
            100                 105                 110         


Ser Asp Ser Ser Glu Glu Leu Ser Pro Thr Ala Lys Phe Thr Ser Asp 
        115                 120                 125             


Pro Ile Gly Glu Val Leu Val Ser Ser Gly Lys Leu Ser Ser Ser Val 
    130                 135                 140                 


Thr Ser Thr Pro Pro Ser Ser Pro Glu Leu Ser Arg Glu Pro Ser Gln 
145                 150                 155                 160 


Leu Trp Gly Cys Val Pro Gly Glu Leu Pro Ser Pro Gly Lys Val Arg 
                165                 170                 175     


Ser Gly Thr Ser Gly Lys Pro Gly Asp Lys Gly Asn Gly Asp Ala Ser 
            180                 185                 190         


Pro Asp Gly Arg Arg Arg Val His Arg Cys His Phe Asn Gly Cys Arg 
        195                 200                 205             


Lys Val Tyr Thr Lys Ser Ser His Leu Lys Ala His Gln Arg Thr His 
    210                 215                 220                 


Thr Gly Val Phe Pro Gly Leu Thr Thr Trp Pro Cys Thr 
225                 230                 235         


<210>  11
<211>  3938
<212>  DNA
<213>  Homo sapiens

<400>  11
gtactggccc gcgccgtccg cccgccgaca gctccctgag ccagcccggg aggcagccgc       60

gcgcagcgag ccggtggcgc aggtgtcggg gtcctcgagc gcccagcctg ggagcatgat      120

tgtggacaag ctgctggacg acagccgcgg cggagagggg ctgcgggacg cggcgggcgg      180

ctgcggcctc atgaccagcc cgctcaacct gagctacttc tacggcgcgt cgccgcccgc      240

cgccgccccg ggcgcctgcg acgccagctg ctcggtcttg ggcccctcgg cgcccggctc      300

gcccggctcc gactcctccg acttctcctc tgcctcgtcg gtgtcctcct gcggcgccgt      360

ggagtcccgg tcgagaggcg gcgcccgcgc cgagcgccag ccagttgagc cccatatggg      420

ggttggcagg cagcagagag gcccctttca aggtgttcgg gtaaagaact cagtgaagga      480

actcctgttg cacatccgaa gtcataaaca gaaggcttct ggccaagctg tggatgattt      540

taagacacaa ggtgtgaaca tagaacagtt cagagaattg aagaacacag tatcatacag      600

tgggaaaagg aaagggcccg attcgttgtc tgatggacct gcttgcaaaa ggccagctct      660

gttgcattcc caatttttga caccacctca aacaccaacg cccggggaga gcatggaaga      720

tgttcatctc aatgaaccca aacaggagag cagtgctgat ctgcttcaga acattatcaa      780

cattaagaat gaatgcagcc ccgtttccct gaacacagtt caagttagct ggctgaaccc      840

cgtggtggtc cctcagagct cccccgcaga gcagtgtcag gacttccatg gagggcaggt      900

cttttctcca cctcagaaat gccaaccatt ccaagtcagg ggctcccaac aaatgataga      960

ccaggcttcc ctgtaccagt attctccaca gaaccagcat gtagagcagc agccacacta     1020

cacccacaaa ccaactctgg aatacagtcc ttttcccata cctccccagt cccccgctta     1080

tgaaccaaac ctctttgatg gtccagaatc acagttttgc ccaaaccaaa gcttagtttc     1140

ccttcttggt gatcaaaggg aatctgagaa tattgctaat cccatgcaga cttcctccag     1200

tgttcagcag caaaatgatg ctcacttgca cagcttcagc atgatgccca gcagcgcctg     1260

tgaggccatg gtggggcacg agatggcctc tgactcttca aacacttcac tgccattctc     1320

aaacatggga aatccaatga acaccacaca gttagggaaa tcactttttc agtggcaggt     1380

ggagcaggaa gaaagcaaat tggcaaatat ttcccaagac cagtttcttt caaaggatgc     1440

agatggtgac acgttccttc atattgctgt tgcccaaggg agaagggcac tttcctatgt     1500

tcttgcaaga aagatgaatg cacttcacat gctggatatt aaagagcaca atggacagag     1560

tgcctttcag gtggcagtgg ctgccaatca gcatctcatt gtgcaggatc tggtgaacat     1620

cggggcacag gtgaacacca cagactgctg gggaagaaca cctctgcatg tgtgtgctga     1680

gaagggccac tcccaggtgc ttcaggcgat tcagaaggga gcagtgggaa gtaatcagtt     1740

tgtggatctt gaggcaacta actatgatgg cctgactccc cttcactgtg cagtcatagc     1800

ccacaatgct gtggtccatg aactccagag aaatcaacag cctcattcac ctgaagttca     1860

ggagctttta ctgaagaata agagtctggt tgataccatt aagtgcctaa ttcaaatggg     1920

agcagcggtg gaagcgaagg atcgcaaaag tggccgcaca gccctgcatt tggcagctga     1980

agaagcaaat ctggaactca ttcgcctctt tttggagctg cccagttgcc tgtcttttgt     2040

gaatgcaaag gcttacaatg gcaacactgc cctccatgtt gctgccagct tgcagtatcg     2100

gttgacacaa ttagatgctg tccgcctgtt gatgaggaag ggagcagacc caagtactcg     2160

gaacttggag aacgaacagc cagtgcattt ggttcccgat ggccctgtgg gagaacagat     2220

ccgacgtatc ctgaagggaa agtccattca gcagagagct ccaccgtatt agctccatta     2280

gcttggagcc tggctagcaa cactcactgt cagttaggca gtcctgatgt atctgtacat     2340

agaccatttg ccttatattg gcaaatgtaa gttgtttcta tgaaacaaac atatttagtt     2400

cactattata tagtgggtta tattaaaaga aaagaagaaa aatatctaat ttctcttggc     2460

agatttgcat atttcatacc caggtatctg ggatctagac atctgaattt gatctcaatg     2520

gtaacattgc cttcaattaa cagtagcttt tgagtaggaa aggactttga tttgtggcac     2580

aaaacattat taatatagct attgacagtt tcaaagcagg taaattgtaa atgtttcttt     2640

aagaaaaagc atgtgaaagg aaaaaggtaa atacagcatt gaggcttcat ttggccttag     2700

tccctgggag ttactggcgt tggacaggct tcagtcattg gactagatga aaggtgtcca     2760

tggttagaat ttgatctttg caaactgtat ataattgtta tttttgtcct taaaaatatt     2820

gtacatactt ggttgttaac atggtcatat ttgaaatgta taagtccata aaatagaaaa     2880

gaacaagtga attgttgcta tttaaaaaaa ttttacaatt cttactaagg agtttttatt     2940

gtgtaatcac taagtctttg tagataaagc agatggggag ttacggagtt gttcctttac     3000

tggctgaaag atatattcga attgtaaaga tgctttttct catgcattga aattatacat     3060

tatttgtagg gaattgcatg cttttttttt tttttctccc gagacagggt cttgctctgg     3120

cgcccaggct ggagtacagt ggcatgatct tggctcactt cagccttgac ttgggctcaa     3180

gtgatcctcc tacctgagcc ttctgagtaa ctggaactac aggtgtgcac tcctcgcctg     3240

gctaattttt tattttttgt acaggcagga tcttgccacc ttgcccaggc tggtcttgaa     3300

ctcctgagct catgccatct gcctgcctta gtctcccaaa atgctgggat tacaggagtg     3360

agccaccatg cccggctggc agttgcatgg aagagaacac ctctttatgg cttaccctct     3420

agaatttcta atttatgtgt tctgttgaaa tttttgtttt tttaccttta ttgaaacaac     3480

aaaaagtcag tattgaaaca tatcttcctg ttttctgttg tcaaatgatg ataatgtgcc     3540

atgatgtttt atatatatca ttcagaaaaa gttttatttt ttaataacat tctattaaca     3600

ttattttgct tgccgctggc atgcctgagg aatgtatttg gctttgatta cacactaagt     3660

ttttgtaata aatttgactc attaaaaacc tttttttttt aaaaaaaaaa aaaaagaaaa     3720

tctcattagt gaacttatct ttgcagctga gtacttaaat tctttttaaa aagataccct     3780

ttggattgat cacattgttt gacccagtat gtcttgtaga cacgttagtt ataatcacct     3840

tgtatctcta aatatggtgt gatatgaacc agtccattca cattggaaaa actgatggtt     3900

ttaaataaac taattcacta ataaaaaaaa aaaaaaaa                             3938


<210>  12
<211>  718
<212>  PRT
<213>  Homo sapiens

<400>  12

Met Ile Val Asp Lys Leu Leu Asp Asp Ser Arg Gly Gly Glu Gly Leu 
1               5                   10                  15      


Arg Asp Ala Ala Gly Gly Cys Gly Leu Met Thr Ser Pro Leu Asn Leu 
            20                  25                  30          


Ser Tyr Phe Tyr Gly Ala Ser Pro Pro Ala Ala Ala Pro Gly Ala Cys 
        35                  40                  45              


Asp Ala Ser Cys Ser Val Leu Gly Pro Ser Ala Pro Gly Ser Pro Gly 
    50                  55                  60                  


Ser Asp Ser Ser Asp Phe Ser Ser Ala Ser Ser Val Ser Ser Cys Gly 
65                  70                  75                  80  


Ala Val Glu Ser Arg Ser Arg Gly Gly Ala Arg Ala Glu Arg Gln Pro 
                85                  90                  95      


Val Glu Pro His Met Gly Val Gly Arg Gln Gln Arg Gly Pro Phe Gln 
            100                 105                 110         


Gly Val Arg Val Lys Asn Ser Val Lys Glu Leu Leu Leu His Ile Arg 
        115                 120                 125             


Ser His Lys Gln Lys Ala Ser Gly Gln Ala Val Asp Asp Phe Lys Thr 
    130                 135                 140                 


Gln Gly Val Asn Ile Glu Gln Phe Arg Glu Leu Lys Asn Thr Val Ser 
145                 150                 155                 160 


Tyr Ser Gly Lys Arg Lys Gly Pro Asp Ser Leu Ser Asp Gly Pro Ala 
                165                 170                 175     


Cys Lys Arg Pro Ala Leu Leu His Ser Gln Phe Leu Thr Pro Pro Gln 
            180                 185                 190         


Thr Pro Thr Pro Gly Glu Ser Met Glu Asp Val His Leu Asn Glu Pro 
        195                 200                 205             


Lys Gln Glu Ser Ser Ala Asp Leu Leu Gln Asn Ile Ile Asn Ile Lys 
    210                 215                 220                 


Asn Glu Cys Ser Pro Val Ser Leu Asn Thr Val Gln Val Ser Trp Leu 
225                 230                 235                 240 


Asn Pro Val Val Val Pro Gln Ser Ser Pro Ala Glu Gln Cys Gln Asp 
                245                 250                 255     


Phe His Gly Gly Gln Val Phe Ser Pro Pro Gln Lys Cys Gln Pro Phe 
            260                 265                 270         


Gln Val Arg Gly Ser Gln Gln Met Ile Asp Gln Ala Ser Leu Tyr Gln 
        275                 280                 285             


Tyr Ser Pro Gln Asn Gln His Val Glu Gln Gln Pro His Tyr Thr His 
    290                 295                 300                 


Lys Pro Thr Leu Glu Tyr Ser Pro Phe Pro Ile Pro Pro Gln Ser Pro 
305                 310                 315                 320 


Ala Tyr Glu Pro Asn Leu Phe Asp Gly Pro Glu Ser Gln Phe Cys Pro 
                325                 330                 335     


Asn Gln Ser Leu Val Ser Leu Leu Gly Asp Gln Arg Glu Ser Glu Asn 
            340                 345                 350         


Ile Ala Asn Pro Met Gln Thr Ser Ser Ser Val Gln Gln Gln Asn Asp 
        355                 360                 365             


Ala His Leu His Ser Phe Ser Met Met Pro Ser Ser Ala Cys Glu Ala 
    370                 375                 380                 


Met Val Gly His Glu Met Ala Ser Asp Ser Ser Asn Thr Ser Leu Pro 
385                 390                 395                 400 


Phe Ser Asn Met Gly Asn Pro Met Asn Thr Thr Gln Leu Gly Lys Ser 
                405                 410                 415     


Leu Phe Gln Trp Gln Val Glu Gln Glu Glu Ser Lys Leu Ala Asn Ile 
            420                 425                 430         


Ser Gln Asp Gln Phe Leu Ser Lys Asp Ala Asp Gly Asp Thr Phe Leu 
        435                 440                 445             


His Ile Ala Val Ala Gln Gly Arg Arg Ala Leu Ser Tyr Val Leu Ala 
    450                 455                 460                 


Arg Lys Met Asn Ala Leu His Met Leu Asp Ile Lys Glu His Asn Gly 
465                 470                 475                 480 


Gln Ser Ala Phe Gln Val Ala Val Ala Ala Asn Gln His Leu Ile Val 
                485                 490                 495     


Gln Asp Leu Val Asn Ile Gly Ala Gln Val Asn Thr Thr Asp Cys Trp 
            500                 505                 510         


Gly Arg Thr Pro Leu His Val Cys Ala Glu Lys Gly His Ser Gln Val 
        515                 520                 525             


Leu Gln Ala Ile Gln Lys Gly Ala Val Gly Ser Asn Gln Phe Val Asp 
    530                 535                 540                 


Leu Glu Ala Thr Asn Tyr Asp Gly Leu Thr Pro Leu His Cys Ala Val 
545                 550                 555                 560 


Ile Ala His Asn Ala Val Val His Glu Leu Gln Arg Asn Gln Gln Pro 
                565                 570                 575     


His Ser Pro Glu Val Gln Glu Leu Leu Leu Lys Asn Lys Ser Leu Val 
            580                 585                 590         


Asp Thr Ile Lys Cys Leu Ile Gln Met Gly Ala Ala Val Glu Ala Lys 
        595                 600                 605             


Asp Arg Lys Ser Gly Arg Thr Ala Leu His Leu Ala Ala Glu Glu Ala 
    610                 615                 620                 


Asn Leu Glu Leu Ile Arg Leu Phe Leu Glu Leu Pro Ser Cys Leu Ser 
625                 630                 635                 640 


Phe Val Asn Ala Lys Ala Tyr Asn Gly Asn Thr Ala Leu His Val Ala 
                645                 650                 655     


Ala Ser Leu Gln Tyr Arg Leu Thr Gln Leu Asp Ala Val Arg Leu Leu 
            660                 665                 670         


Met Arg Lys Gly Ala Asp Pro Ser Thr Arg Asn Leu Glu Asn Glu Gln 
        675                 680                 685             


Pro Val His Leu Val Pro Asp Gly Pro Val Gly Glu Gln Ile Arg Arg 
    690                 695                 700                 


Ile Leu Lys Gly Lys Ser Ile Gln Gln Arg Ala Pro Pro Tyr 
705                 710                 715             


<210>  13
<211>  3782
<212>  DNA
<213>  Homo sapiens

<400>  13
ggcgagttct tagagaaaaa ggctgcttag ctgctgctta tcatgtaacc tcaaaaggaa       60

actgatcgtc tttctcatgc tgtcacgtac ttgggttatt atcgctgatt acagctggaa      120

acaattgatt tgctcttacg tatttgtgtg acttgactct tcaaacacaa aggttaacag      180

gaagatctcg agggccctgg ctgaacttca ccttttggct ttcttggcct gatgctgaac      240

tctcgaggtt gagccccata tgggggttgg caggcagcag agaggcccct ttcaaggtgt      300

tcgggtaaag aactcagtga aggaactcct gttgcacatc cgaagtcata aacagaaggc      360

ttctggccaa gctgtggatg attttaagac acaaggtgtg aacatagaac agttcagaga      420

attgaagaac acagtatcat acagtgggaa aaggaaaggg cccgattcgt tgtctgatgg      480

acctgcttgc aaaaggccag ctctgttgca ttcccaattt ttgacaccac ctcaaacacc      540

aacgcccggg gagagcatgg aagatgttca tctcaatgaa cccaaacagg agagcagtgc      600

tgatctgctt cagaacatta tcaacattaa gaatgaatgc agccccgttt ccctgaacac      660

agttcaagtt agctggctga accccgtggt ggtccctcag agctcccccg cagagcagtg      720

tcaggacttc catggagggc aggtcttttc tccacctcag aaatgccaac cattccaagt      780

caggggctcc caacaaatga tagaccaggc ttccctgtac cagtattctc cacagaacca      840

gcatgtagag cagcagccac actacaccca caaaccaact ctggaataca gtccttttcc      900

catacctccc cagtcccccg cttatgaacc aaacctcttt gatggtccag aatcacagtt      960

ttgcccaaac caaagcttag tttcccttct tggtgatcaa agggaatctg agaatattgc     1020

taatcccatg cagacttcct ccagtgttca gcagcaaaat gatgctcact tgcacagctt     1080

cagcatgatg cccagcagcg cctgtgaggc catggtgggg cacgagatgg cctctgactc     1140

ttcaaacact tcactgccat tctcaaacat gggaaatcca atgaacacca cacagttagg     1200

gaaatcactt tttcagtggc aggtggagca ggaagaaagc aaattggcaa atatttccca     1260

agaccagttt ctttcaaagg atgcagatgg tgacacgttc cttcatattg ctgttgccca     1320

agggagaagg gcactttcct atgttcttgc aagaaagatg aatgcacttc acatgctgga     1380

tattaaagag cacaatggac agagtgcctt tcaggtggca gtggctgcca atcagcatct     1440

cattgtgcag gatctggtga acatcggggc acaggtgaac accacagact gctggggaag     1500

aacacctctg catgtgtgtg ctgagaaggg ccactcccag gtgcttcagg cgattcagaa     1560

gggagcagtg ggaagtaatc agtttgtgga tcttgaggca actaactatg atggcctgac     1620

tccccttcac tgtgcagtca tagcccacaa tgctgtggtc catgaactcc agagaaatca     1680

acagcctcat tcacctgaag ttcaggagct tttactgaag aataagagtc tggttgatac     1740

cattaagtgc ctaattcaaa tgggagcagc ggtggaagcg aaggatcgca aaagtggccg     1800

cacagccctg catttggcag ctgaagaagc aaatctggaa ctcattcgcc tctttttgga     1860

gctgcccagt tgcctgtctt ttgtgaatgc aaaggcttac aatggcaaca ctgccctcca     1920

tgttgctgcc agcttgcagt atcggttgac acaattagat gctgtccgcc tgttgatgag     1980

gaagggagca gacccaagta ctcggaactt ggagaacgaa cagccagtgc atttggttcc     2040

cgatggccct gtgggagaac agatccgacg tatcctgaag ggaaagtcca ttcagcagag     2100

agctccaccg tattagctcc attagcttgg agcctggcta gcaacactca ctgtcagtta     2160

ggcagtcctg atgtatctgt acatagacca tttgccttat attggcaaat gtaagttgtt     2220

tctatgaaac aaacatattt agttcactat tatatagtgg gttatattaa aagaaaagaa     2280

gaaaaatatc taatttctct tggcagattt gcatatttca tacccaggta tctgggatct     2340

agacatctga atttgatctc aatggtaaca ttgccttcaa ttaacagtag cttttgagta     2400

ggaaaggact ttgatttgtg gcacaaaaca ttattaatat agctattgac agtttcaaag     2460

caggtaaatt gtaaatgttt ctttaagaaa aagcatgtga aaggaaaaag gtaaatacag     2520

cattgaggct tcatttggcc ttagtccctg ggagttactg gcgttggaca ggcttcagtc     2580

attggactag atgaaaggtg tccatggtta gaatttgatc tttgcaaact gtatataatt     2640

gttatttttg tccttaaaaa tattgtacat acttggttgt taacatggtc atatttgaaa     2700

tgtataagtc cataaaatag aaaagaacaa gtgaattgtt gctatttaaa aaaattttac     2760

aattcttact aaggagtttt tattgtgtaa tcactaagtc tttgtagata aagcagatgg     2820

ggagttacgg agttgttcct ttactggctg aaagatatat tcgaattgta aagatgcttt     2880

ttctcatgca ttgaaattat acattatttg tagggaattg catgcttttt tttttttttc     2940

tcccgagaca gggtcttgct ctggcgccca ggctggagta cagtggcatg atcttggctc     3000

acttcagcct tgacttgggc tcaagtgatc ctcctacctg agccttctga gtaactggaa     3060

ctacaggtgt gcactcctcg cctggctaat tttttatttt ttgtacaggc aggatcttgc     3120

caccttgccc aggctggtct tgaactcctg agctcatgcc atctgcctgc cttagtctcc     3180

caaaatgctg ggattacagg agtgagccac catgcccggc tggcagttgc atggaagaga     3240

acacctcttt atggcttacc ctctagaatt tctaatttat gtgttctgtt gaaatttttg     3300

tttttttacc tttattgaaa caacaaaaag tcagtattga aacatatctt cctgttttct     3360

gttgtcaaat gatgataatg tgccatgatg ttttatatat atcattcaga aaaagtttta     3420

ttttttaata acattctatt aacattattt tgcttgccgc tggcatgcct gaggaatgta     3480

tttggctttg attacacact aagtttttgt aataaatttg actcattaaa aacctttttt     3540

ttttaaaaaa aaaaaaaaag aaaatctcat tagtgaactt atctttgcag ctgagtactt     3600

aaattctttt taaaaagata ccctttggat tgatcacatt gtttgaccca gtatgtcttg     3660

tagacacgtt agttataatc accttgtatc tctaaatatg gtgtgatatg aaccagtcca     3720

ttcacattgg aaaaactgat ggttttaaat aaactaattc actaataaaa aaaaaaaaaa     3780

aa                                                                    3782


<210>  14
<211>  618
<212>  PRT
<213>  Homo sapiens

<400>  14

Met Gly Val Gly Arg Gln Gln Arg Gly Pro Phe Gln Gly Val Arg Val 
1               5                   10                  15      


Lys Asn Ser Val Lys Glu Leu Leu Leu His Ile Arg Ser His Lys Gln 
            20                  25                  30          


Lys Ala Ser Gly Gln Ala Val Asp Asp Phe Lys Thr Gln Gly Val Asn 
        35                  40                  45              


Ile Glu Gln Phe Arg Glu Leu Lys Asn Thr Val Ser Tyr Ser Gly Lys 
    50                  55                  60                  


Arg Lys Gly Pro Asp Ser Leu Ser Asp Gly Pro Ala Cys Lys Arg Pro 
65                  70                  75                  80  


Ala Leu Leu His Ser Gln Phe Leu Thr Pro Pro Gln Thr Pro Thr Pro 
                85                  90                  95      


Gly Glu Ser Met Glu Asp Val His Leu Asn Glu Pro Lys Gln Glu Ser 
            100                 105                 110         


Ser Ala Asp Leu Leu Gln Asn Ile Ile Asn Ile Lys Asn Glu Cys Ser 
        115                 120                 125             


Pro Val Ser Leu Asn Thr Val Gln Val Ser Trp Leu Asn Pro Val Val 
    130                 135                 140                 


Val Pro Gln Ser Ser Pro Ala Glu Gln Cys Gln Asp Phe His Gly Gly 
145                 150                 155                 160 


Gln Val Phe Ser Pro Pro Gln Lys Cys Gln Pro Phe Gln Val Arg Gly 
                165                 170                 175     


Ser Gln Gln Met Ile Asp Gln Ala Ser Leu Tyr Gln Tyr Ser Pro Gln 
            180                 185                 190         


Asn Gln His Val Glu Gln Gln Pro His Tyr Thr His Lys Pro Thr Leu 
        195                 200                 205             


Glu Tyr Ser Pro Phe Pro Ile Pro Pro Gln Ser Pro Ala Tyr Glu Pro 
    210                 215                 220                 


Asn Leu Phe Asp Gly Pro Glu Ser Gln Phe Cys Pro Asn Gln Ser Leu 
225                 230                 235                 240 


Val Ser Leu Leu Gly Asp Gln Arg Glu Ser Glu Asn Ile Ala Asn Pro 
                245                 250                 255     


Met Gln Thr Ser Ser Ser Val Gln Gln Gln Asn Asp Ala His Leu His 
            260                 265                 270         


Ser Phe Ser Met Met Pro Ser Ser Ala Cys Glu Ala Met Val Gly His 
        275                 280                 285             


Glu Met Ala Ser Asp Ser Ser Asn Thr Ser Leu Pro Phe Ser Asn Met 
    290                 295                 300                 


Gly Asn Pro Met Asn Thr Thr Gln Leu Gly Lys Ser Leu Phe Gln Trp 
305                 310                 315                 320 


Gln Val Glu Gln Glu Glu Ser Lys Leu Ala Asn Ile Ser Gln Asp Gln 
                325                 330                 335     


Phe Leu Ser Lys Asp Ala Asp Gly Asp Thr Phe Leu His Ile Ala Val 
            340                 345                 350         


Ala Gln Gly Arg Arg Ala Leu Ser Tyr Val Leu Ala Arg Lys Met Asn 
        355                 360                 365             


Ala Leu His Met Leu Asp Ile Lys Glu His Asn Gly Gln Ser Ala Phe 
    370                 375                 380                 


Gln Val Ala Val Ala Ala Asn Gln His Leu Ile Val Gln Asp Leu Val 
385                 390                 395                 400 


Asn Ile Gly Ala Gln Val Asn Thr Thr Asp Cys Trp Gly Arg Thr Pro 
                405                 410                 415     


Leu His Val Cys Ala Glu Lys Gly His Ser Gln Val Leu Gln Ala Ile 
            420                 425                 430         


Gln Lys Gly Ala Val Gly Ser Asn Gln Phe Val Asp Leu Glu Ala Thr 
        435                 440                 445             


Asn Tyr Asp Gly Leu Thr Pro Leu His Cys Ala Val Ile Ala His Asn 
    450                 455                 460                 


Ala Val Val His Glu Leu Gln Arg Asn Gln Gln Pro His Ser Pro Glu 
465                 470                 475                 480 


Val Gln Glu Leu Leu Leu Lys Asn Lys Ser Leu Val Asp Thr Ile Lys 
                485                 490                 495     


Cys Leu Ile Gln Met Gly Ala Ala Val Glu Ala Lys Asp Arg Lys Ser 
            500                 505                 510         


Gly Arg Thr Ala Leu His Leu Ala Ala Glu Glu Ala Asn Leu Glu Leu 
        515                 520                 525             


Ile Arg Leu Phe Leu Glu Leu Pro Ser Cys Leu Ser Phe Val Asn Ala 
    530                 535                 540                 


Lys Ala Tyr Asn Gly Asn Thr Ala Leu His Val Ala Ala Ser Leu Gln 
545                 550                 555                 560 


Tyr Arg Leu Thr Gln Leu Asp Ala Val Arg Leu Leu Met Arg Lys Gly 
                565                 570                 575     


Ala Asp Pro Ser Thr Arg Asn Leu Glu Asn Glu Gln Pro Val His Leu 
            580                 585                 590         


Val Pro Asp Gly Pro Val Gly Glu Gln Ile Arg Arg Ile Leu Lys Gly 
        595                 600                 605             


Lys Ser Ile Gln Gln Arg Ala Pro Pro Tyr 
    610                 615             


<210>  15
<211>  3582
<212>  DNA
<213>  Homo sapiens

<400>  15
gttgggtggg agcacaggca ccgggcacca tggggaaggc cgagaactat gagctctact       60

cggtggagct gggtcctggc cctggcgggg acatggctgc caagatgagc aagaagaaga      120

aggcgggtgg cgggggtggc aagaggaagg agaagctgga gaacatgaag aaggagatgg      180

agattaacga ccaccagctg tcagtggcgg agctggaaca gaaataccag accagtgcca      240

ccaagggcct ctctgcgagc ctggctgctg agctgctgct gcgggatggg cccaacgcac      300

tgcggccacc acggggcacc ccagagtacg tcaagttcgc gaggcagctg gccgggggcc      360

tgcagtgcct catgtgggtt gccgccgcca tctgcctcat cgcctttgcc atccaggcta      420

gtgaggggga cctcaccacc gacgacaatc tgtacctggc aatcgctctc attgctgtgg      480

ttgtcgtcac cggctgcttt ggctactacc aggaattcaa gagcaccaac atcatcgcca      540

gctttaagaa ccttgtgcca cagcaagcca ctgtcatccg cgatggagac aaattccaga      600

tcaacgctga ccaactggtg gtgggcgacc tggtggagat gaaaggtggg gacagagtgc      660

ccgccgacat ccgcatcctg gcggcccagg gctgcaaggt ggacaactcc tcgctgacag      720

gggagtctga gccacagacc cgctcacccg agtgcacgca cgagagccct ctggagaccc      780

gcaacatcgc cttcttctcc accatgtgcc ttgagggcac cgtgcagggc ctggtggtga      840

acacgggcga ccgcaccatc attgggcgca tcgcatcgct ggcgtcgggg gtggaaaacg      900

agaagacacc catcgctatc gagatcgagc attttgtgga catcatcgcg ggcctggcca      960

ttctcttcgg tgccacattt tttattgtgg ccatgtgcat tggctacacc ttcctgcggg     1020

ccatggtctt cttcatggcc atcgtggtgg cctatgtgcc tgaggggctg ctggccactg     1080

tcacagtctg cctgtccctg acagccaagc gcctggccag taagaactgc gtggtcaaga     1140

acctggaggc ggtggagaca ttgggctcca cttcggtgat ctgctcggac aagacaggga     1200

ctctcactca gaaccgcatg actgtgtccc atctgtggtt tgacaaccac atccacacag     1260

ctgacaccac ggaagaccag tcagggcaga cgtttgacca gtcctcggag acgtggcggg     1320

cgctgtgccg ggtgctcacc ctgtgcaacc gcgccgcctt caagtccggc caggatgcag     1380

tgcctgtgcc caagcgcatc gtgattggag acgcatcgga gacggcgctg ctcaagttct     1440

cggagctgac gctgggcaac gccatgggct accgggaccg cttcccaaaa gtctgcgaga     1500

tacccttcaa ctccaccaac aagttccagc tgtccatcca tacgctggag gacccgcggg     1560

acccgcgaca cttgctggtg atgaagggcg cccccgagcg cgtgctggag cgctgcagct     1620

ccatccttat caagggccag gagctgccgc tggacgagca gtggcgcgag gccttccaga     1680

ccgcctacct cagcctggga ggcctgggcg aacgcgtgct cggcttctgc cagctctacc     1740

tgaatgagaa ggactacccg cctggctatg ccttcgacgt agaggccatg aactttccat     1800

ctagcggcct ctgctttgcg ggacttgtat ccatgattga cccaccccgg gccaccgtcc     1860

ctgatgctgt gctcaagtgt cgcaccgcag gcatccgggt gatcatggta acgggtgacc     1920

accccatcac cgccaaggcc attgcagcca gtgtgggcat catctcggaa ggcagcgaga     1980

cagtggagga catcgctgcc cgcctccgtg tgcccgtaga ccaggttaat cgcaaggatg     2040

cccgtgcctg tgtgatcaat ggcatgcagc tgaaggacat ggacccatcg gaactggtcg     2100

aggccctgcg cacccacccc gagatggtgt ttgcgcgcac cagcccccag cagaagctgg     2160

tgatcgtgga gagctgccag cggctgggtg cgattgtggc cgtcacgggg gatggtgtga     2220

atgactcccc agctctgaag aaggcagaca tcggagtagc catgggcatc gctggctcag     2280

atgctgccaa aaatgcagct gacatgatcc tgctggatga caactttgcc tccattgtga     2340

caggcgtgga gcagggtcga ctgatcttcg acaacctgaa gaagtctatt gcctacacat     2400

tgaccaagaa catcccagag ctgacaccct acctcatcta catcaccgtc agcgtgcccc     2460

tgcccctcgg gtgcatcacc atcctcttca tcgaactctg cactgacatt ttcccatctg     2520

tgtccctggc atatgaaaag gccgagagtg acatcatgca cctgcgtcca cgcaacccaa     2580

agcgtgacag attggtcaac gagcccctgg ctgcctactc ctacttccag attggtgcca     2640

ttcagtcctt tgctggcttc actgactact tcacggcaat ggcccaggag ggctggttcc     2700

cactgctgtg cgtggggctg cgggcgcagt gggaggacca ccacctacaa gatctgcagg     2760

acagctacgg ccaggagtgg acattcgggc agcgcctgta ccagcagtac acctgctaca     2820

ccgtgttctt catcagcatt gaggtgtgcc agatcgccga tgtcctcatc cgcaagacgc     2880

gccgtctctc tgccttccag caaggcttct tcaggaataa gatcctggtg atcgccatcg     2940

tgttccaggt ctgcatcggc tgcttcctgt gctactgccc cggcatgccc aacatcttca     3000

acttcatgcc cattcggttc cagtggtggc tggtccccct gccctacggc atcctcatct     3060

tcgtctatga tgagatccgg aagcttggag ttcgctgttg cccagggagc tggtgggacc     3120

aggaactcta ctattagagg gacgactgcc ttcaagcatc cctgcaactg ccacagcagg     3180

tgggggcagg gctcgtggga ccctctggac agccaccaag atatctgagc aaccaagagt     3240

cccagcccca ccagtatctg cttctgtagc ccacggcacc ccaaacttgg agggacctgc     3300

ccactcccct cccccattcc caaggttcgc acctcctgga gcagcagcgc ctgggcagtc     3360

ctctgggctg gcctcgggaa agccgccacc tgtggtggcg gtggggctct gacagggagt     3420

acagctgacc gcttctggag ggtgtttctg ttcttaggac tccagtccag gctggacggc     3480

tgcctgaggg cccttcgtta aagacacgct tgtgtcctgg gcgatggtaa taaaaccagc     3540

tcatgctgac tgtgctgtaa aaaaaaaaaa aaaaaaaaaa aa                        3582


<210>  16
<211>  1035
<212>  PRT
<213>  Homo sapiens

<400>  16

Met Gly Lys Ala Glu Asn Tyr Glu Leu Tyr Ser Val Glu Leu Gly Pro 
1               5                   10                  15      


Gly Pro Gly Gly Asp Met Ala Ala Lys Met Ser Lys Lys Lys Lys Ala 
            20                  25                  30          


Gly Gly Gly Gly Gly Lys Arg Lys Glu Lys Leu Glu Asn Met Lys Lys 
        35                  40                  45              


Glu Met Glu Ile Asn Asp His Gln Leu Ser Val Ala Glu Leu Glu Gln 
    50                  55                  60                  


Lys Tyr Gln Thr Ser Ala Thr Lys Gly Leu Ser Ala Ser Leu Ala Ala 
65                  70                  75                  80  


Glu Leu Leu Leu Arg Asp Gly Pro Asn Ala Leu Arg Pro Pro Arg Gly 
                85                  90                  95      


Thr Pro Glu Tyr Val Lys Phe Ala Arg Gln Leu Ala Gly Gly Leu Gln 
            100                 105                 110         


Cys Leu Met Trp Val Ala Ala Ala Ile Cys Leu Ile Ala Phe Ala Ile 
        115                 120                 125             


Gln Ala Ser Glu Gly Asp Leu Thr Thr Asp Asp Asn Leu Tyr Leu Ala 
    130                 135                 140                 


Ile Ala Leu Ile Ala Val Val Val Val Thr Gly Cys Phe Gly Tyr Tyr 
145                 150                 155                 160 


Gln Glu Phe Lys Ser Thr Asn Ile Ile Ala Ser Phe Lys Asn Leu Val 
                165                 170                 175     


Pro Gln Gln Ala Thr Val Ile Arg Asp Gly Asp Lys Phe Gln Ile Asn 
            180                 185                 190         


Ala Asp Gln Leu Val Val Gly Asp Leu Val Glu Met Lys Gly Gly Asp 
        195                 200                 205             


Arg Val Pro Ala Asp Ile Arg Ile Leu Ala Ala Gln Gly Cys Lys Val 
    210                 215                 220                 


Asp Asn Ser Ser Leu Thr Gly Glu Ser Glu Pro Gln Thr Arg Ser Pro 
225                 230                 235                 240 


Glu Cys Thr His Glu Ser Pro Leu Glu Thr Arg Asn Ile Ala Phe Phe 
                245                 250                 255     


Ser Thr Met Cys Leu Glu Gly Thr Val Gln Gly Leu Val Val Asn Thr 
            260                 265                 270         


Gly Asp Arg Thr Ile Ile Gly Arg Ile Ala Ser Leu Ala Ser Gly Val 
        275                 280                 285             


Glu Asn Glu Lys Thr Pro Ile Ala Ile Glu Ile Glu His Phe Val Asp 
    290                 295                 300                 


Ile Ile Ala Gly Leu Ala Ile Leu Phe Gly Ala Thr Phe Phe Ile Val 
305                 310                 315                 320 


Ala Met Cys Ile Gly Tyr Thr Phe Leu Arg Ala Met Val Phe Phe Met 
                325                 330                 335     


Ala Ile Val Val Ala Tyr Val Pro Glu Gly Leu Leu Ala Thr Val Thr 
            340                 345                 350         


Val Cys Leu Ser Leu Thr Ala Lys Arg Leu Ala Ser Lys Asn Cys Val 
        355                 360                 365             


Val Lys Asn Leu Glu Ala Val Glu Thr Leu Gly Ser Thr Ser Val Ile 
    370                 375                 380                 


Cys Ser Asp Lys Thr Gly Thr Leu Thr Gln Asn Arg Met Thr Val Ser 
385                 390                 395                 400 


His Leu Trp Phe Asp Asn His Ile His Thr Ala Asp Thr Thr Glu Asp 
                405                 410                 415     


Gln Ser Gly Gln Thr Phe Asp Gln Ser Ser Glu Thr Trp Arg Ala Leu 
            420                 425                 430         


Cys Arg Val Leu Thr Leu Cys Asn Arg Ala Ala Phe Lys Ser Gly Gln 
        435                 440                 445             


Asp Ala Val Pro Val Pro Lys Arg Ile Val Ile Gly Asp Ala Ser Glu 
    450                 455                 460                 


Thr Ala Leu Leu Lys Phe Ser Glu Leu Thr Leu Gly Asn Ala Met Gly 
465                 470                 475                 480 


Tyr Arg Asp Arg Phe Pro Lys Val Cys Glu Ile Pro Phe Asn Ser Thr 
                485                 490                 495     


Asn Lys Phe Gln Leu Ser Ile His Thr Leu Glu Asp Pro Arg Asp Pro 
            500                 505                 510         


Arg His Leu Leu Val Met Lys Gly Ala Pro Glu Arg Val Leu Glu Arg 
        515                 520                 525             


Cys Ser Ser Ile Leu Ile Lys Gly Gln Glu Leu Pro Leu Asp Glu Gln 
    530                 535                 540                 


Trp Arg Glu Ala Phe Gln Thr Ala Tyr Leu Ser Leu Gly Gly Leu Gly 
545                 550                 555                 560 


Glu Arg Val Leu Gly Phe Cys Gln Leu Tyr Leu Asn Glu Lys Asp Tyr 
                565                 570                 575     


Pro Pro Gly Tyr Ala Phe Asp Val Glu Ala Met Asn Phe Pro Ser Ser 
            580                 585                 590         


Gly Leu Cys Phe Ala Gly Leu Val Ser Met Ile Asp Pro Pro Arg Ala 
        595                 600                 605             


Thr Val Pro Asp Ala Val Leu Lys Cys Arg Thr Ala Gly Ile Arg Val 
    610                 615                 620                 


Ile Met Val Thr Gly Asp His Pro Ile Thr Ala Lys Ala Ile Ala Ala 
625                 630                 635                 640 


Ser Val Gly Ile Ile Ser Glu Gly Ser Glu Thr Val Glu Asp Ile Ala 
                645                 650                 655     


Ala Arg Leu Arg Val Pro Val Asp Gln Val Asn Arg Lys Asp Ala Arg 
            660                 665                 670         


Ala Cys Val Ile Asn Gly Met Gln Leu Lys Asp Met Asp Pro Ser Glu 
        675                 680                 685             


Leu Val Glu Ala Leu Arg Thr His Pro Glu Met Val Phe Ala Arg Thr 
    690                 695                 700                 


Ser Pro Gln Gln Lys Leu Val Ile Val Glu Ser Cys Gln Arg Leu Gly 
705                 710                 715                 720 


Ala Ile Val Ala Val Thr Gly Asp Gly Val Asn Asp Ser Pro Ala Leu 
                725                 730                 735     


Lys Lys Ala Asp Ile Gly Val Ala Met Gly Ile Ala Gly Ser Asp Ala 
            740                 745                 750         


Ala Lys Asn Ala Ala Asp Met Ile Leu Leu Asp Asp Asn Phe Ala Ser 
        755                 760                 765             


Ile Val Thr Gly Val Glu Gln Gly Arg Leu Ile Phe Asp Asn Leu Lys 
    770                 775                 780                 


Lys Ser Ile Ala Tyr Thr Leu Thr Lys Asn Ile Pro Glu Leu Thr Pro 
785                 790                 795                 800 


Tyr Leu Ile Tyr Ile Thr Val Ser Val Pro Leu Pro Leu Gly Cys Ile 
                805                 810                 815     


Thr Ile Leu Phe Ile Glu Leu Cys Thr Asp Ile Phe Pro Ser Val Ser 
            820                 825                 830         


Leu Ala Tyr Glu Lys Ala Glu Ser Asp Ile Met His Leu Arg Pro Arg 
        835                 840                 845             


Asn Pro Lys Arg Asp Arg Leu Val Asn Glu Pro Leu Ala Ala Tyr Ser 
    850                 855                 860                 


Tyr Phe Gln Ile Gly Ala Ile Gln Ser Phe Ala Gly Phe Thr Asp Tyr 
865                 870                 875                 880 


Phe Thr Ala Met Ala Gln Glu Gly Trp Phe Pro Leu Leu Cys Val Gly 
                885                 890                 895     


Leu Arg Ala Gln Trp Glu Asp His His Leu Gln Asp Leu Gln Asp Ser 
            900                 905                 910         


Tyr Gly Gln Glu Trp Thr Phe Gly Gln Arg Leu Tyr Gln Gln Tyr Thr 
        915                 920                 925             


Cys Tyr Thr Val Phe Phe Ile Ser Ile Glu Val Cys Gln Ile Ala Asp 
    930                 935                 940                 


Val Leu Ile Arg Lys Thr Arg Arg Leu Ser Ala Phe Gln Gln Gly Phe 
945                 950                 955                 960 


Phe Arg Asn Lys Ile Leu Val Ile Ala Ile Val Phe Gln Val Cys Ile 
                965                 970                 975     


Gly Cys Phe Leu Cys Tyr Cys Pro Gly Met Pro Asn Ile Phe Asn Phe 
            980                 985                 990         


Met Pro Ile Arg Phe Gln Trp Trp  Leu Val Pro Leu Pro  Tyr Gly Ile 
        995                 1000                 1005             


Leu Ile  Phe Val Tyr Asp Glu  Ile Arg Lys Leu Gly  Val Arg Cys 
    1010                 1015                 1020             


Cys Pro  Gly Ser Trp Trp Asp  Gln Glu Leu Tyr Tyr  
    1025                 1030                 1035 


<210>  17
<211>  2066
<212>  DNA
<213>  Homo sapiens

<400>  17
agcatttaat catgaggcac tccaaagaat atgagataga aggggagggg taggaggaga       60

gggaggaggg taggaagaca gtttgcattc ttgcaacatt aaaccaaagg gacttggagt      120

gcagatggca tccttcggtt cttccagaca agctgcaaga cgctgaccat ggccaagatg      180

gagctctcga aggccttctc tggccagcgg acactcctat ctgccatcct cagcatgcta      240

tcactcagct tctccacaac atccctgctc agcaactact ggtttgtggg cacacagaag      300

gtgcccaagc ccctgtgcga gaaaggtctg gcagccaagt gctttgacat gccagtgtcc      360

ctggatggag ataccaacac atccacccag gaggtggtac aatacaactg ggagactggg      420

gatgaccggt tctccttccg gagcttccgg agtggcatgt ggctatcctg tgaggaaact      480

gtggaagaac caggggagag gtgccgaagt ttcattgaac ttacaccacc agccaagaga      540

ggtgagaaag gactactgga atttgccacg ttgcaaggcc catgtcaccc cactctccga      600

tttggaggga agcggttgat ggagaaggct tccctcccct cccctccctt ggggctttgt      660

ggcaaaaatc ctatggttat ccctgggaac gcagatcacc tacatcggac ttcaattcat      720

cagcttcctc ctgctactaa cagacttgct actcactggg aaccctgcct gtgggctcaa      780

actgagcgcc tttgctgctg tttcctctgt cctgtcaggt ctcctgggga tggtggccca      840

catgatgtat tcacaagtct tccaagcgac tgtcaacttg ggtccagaag actggagacc      900

acatgtttgg aattatggct gggccttcta catggcctgg ctctccttca cctgctgcat      960

ggcgtcggct gtcaccacct tcaacacgta caccaggatg gtgctggagt tcaagtgcaa     1020

gcatagtaag agcttcaagg aaaacccgaa ctgcctacca catcaccatc agtgtttccc     1080

tcggcggctg tcaagtgcag cccccaccgt gggtcctttg accagctacc accagtatca     1140

taatcagccc atccactctg tctctgaggg agtcgacttc tactccgagc tgcggaacaa     1200

gggatttcaa agaggggcca gccaggagct gaaagaagca gttaggtcat ctgtagagga     1260

agagcagtgt taggagttaa gcgggtttgg ggagtaggct tgagccctac cttacacgtc     1320

tgctgattat caacatgtgc ttaagccaac atccgtctct tgagcatggt ttttagaggc     1380

tacgaataag gctatgaata agggttatct ttaagtccta agggattcct gggtgccact     1440

gctctctttt cctctacagc tccatcttgt ttcacccacc ccacatctca cacatccaga     1500

attcccttct ttactgatag tttctgtgcc aggttctggg ctaaaccatg gagataaaaa     1560

gaagagtaaa atacacttcc cgaccttaag gatctgatac atctagttat tggtctggaa     1620

attggagaaa tggaggtgag caaattaacg gtagtgtgac tgtggctcaa ctttccatgg     1680

tacgcgcgaa ttgttctgga agtcacagat gggaagacag aagcgcccct gagtgctttg     1740

tcatatagca cagaagtcct ccacactgcc tgggacagtg tcctgcatcc acacagtagg     1800

tacccagtaa aagtgttatt aaatattgtc ccaggagccc ttaggagagt ggtttaacat     1860

gagaaggcgc caacagcaca cagggtcagg gtcacttcta gaaatagccc accaaggcta     1920

ttcagattgg actgtggttc ccttctggac agtcacacca gggacttccc agtgaacaag     1980

ggggcatagg ctcctctctg gatcccacct tttcatccct tctgagaaat gtaccctatt     2040

atttccttca taaagaatgc caccca                                          2066


<210>  18
<211>  285
<212>  PRT
<213>  Homo sapiens

<400>  18

Met Ala Lys Met Glu Leu Ser Lys Ala Phe Ser Gly Gln Arg Thr Leu 
1               5                   10                  15      


Leu Ser Ala Ile Leu Ser Met Leu Ser Leu Ser Phe Ser Thr Thr Ser 
            20                  25                  30          


Leu Leu Ser Asn Tyr Trp Phe Val Gly Thr Gln Lys Val Pro Lys Pro 
        35                  40                  45              


Leu Cys Glu Lys Gly Leu Ala Ala Lys Cys Phe Asp Met Pro Val Ser 
    50                  55                  60                  


Leu Asp Gly Asp Thr Asn Thr Ser Thr Gln Glu Val Val Gln Tyr Asn 
65                  70                  75                  80  


Trp Glu Thr Gly Asp Asp Arg Phe Ser Phe Arg Ser Phe Arg Ser Gly 
                85                  90                  95      


Met Trp Leu Ser Cys Glu Glu Thr Val Glu Glu Pro Gly Glu Arg Cys 
            100                 105                 110         


Arg Ser Phe Ile Glu Leu Thr Pro Pro Ala Lys Arg Gly Glu Lys Gly 
        115                 120                 125             


Leu Leu Glu Phe Ala Thr Leu Gln Gly Pro Cys His Pro Thr Leu Arg 
    130                 135                 140                 


Phe Gly Gly Lys Arg Leu Met Glu Lys Ala Ser Leu Pro Ser Pro Pro 
145                 150                 155                 160 


Leu Gly Leu Cys Gly Lys Asn Pro Met Val Ile Pro Gly Asn Ala Asp 
                165                 170                 175     


His Leu His Arg Thr Ser Ile His Gln Leu Pro Pro Ala Thr Asn Arg 
            180                 185                 190         


Leu Ala Thr His Trp Glu Pro Cys Leu Trp Ala Gln Thr Glu Arg Leu 
        195                 200                 205             


Cys Cys Cys Phe Leu Cys Pro Val Arg Ser Pro Gly Asp Gly Gly Pro 
    210                 215                 220                 


His Asp Val Phe Thr Ser Leu Pro Ser Asp Cys Gln Leu Gly Ser Arg 
225                 230                 235                 240 


Arg Leu Glu Thr Thr Cys Leu Glu Leu Trp Leu Gly Leu Leu His Gly 
                245                 250                 255     


Leu Ala Leu Leu His Leu Leu His Gly Val Gly Cys His His Leu Gln 
            260                 265                 270         


His Val His Gln Asp Gly Ala Gly Val Gln Val Gln Ala 
        275                 280                 285 


<210>  19
<211>  1942
<212>  DNA
<213>  Homo sapiens

<400>  19
agcatttaat catgaggcac tccaaagaat atgagataga aggggagggg taggaggaga       60

gggaggaggg taggaagaca gtttgcattc ttgcaacatt aaaccaaagg gacttggagt      120

gcagatggca tccttcggtt cttccagaca agctgcaaga cgctgaccat ggccaagatg      180

gagctctcga aggccttctc tggccagcgg acactcctat ctgccatcct cagcatgcta      240

tcactcagct tctccacaac atccctgctc agcaactact ggtttgtggg cacacagaag      300

gtgcccaagc ccctgtgcga gaaaggtctg gcagccaagt gctttgacat gccagtgtcc      360

ctggatggag ataccaacac atccacccag gaggtggtac aatacaactg ggagactggg      420

gatgaccggt tctccttccg gagcttccgg agtggcatgt ggctatcctg tgaggaaact      480

gtggaagaac caggggagag gtgccgaagt ttcattgaac ttacaccacc agccaagaga      540

gaaatcctat ggttatccct gggaacgcag atcacctaca tcggacttca attcatcagc      600

ttcctcctgc tactaacaga cttgctactc actgggaacc ctgcctgtgg gctcaaactg      660

agcgcctttg ctgctgtttc ctctgtcctg tcaggtctcc tggggatggt ggcccacatg      720

atgtattcac aagtcttcca agcgactgtc aacttgggtc cagaagactg gagaccacat      780

gtttggaatt atggctgggc cttctacatg gcctggctct ccttcacctg ctgcatggcg      840

tcggctgtca ccaccttcaa cacgtacacc aggatggtgc tggagttcaa gtgcaagcat      900

agtaagagct tcaaggaaaa cccgaactgc ctaccacatc accatcagtg tttccctcgg      960

cggctgtcaa gtgcagcccc caccgtgggt cctttgacca gctaccacca gtatcataat     1020

cagcccatcc actctgtctc tgagggagtc gacttctact ccgagctgcg gaacaaggga     1080

tttcaaagag gggccagcca ggagctgaaa gaagcagtta ggtcatctgt agaggaagag     1140

cagtgttagg agttaagcgg gtttggggag taggcttgag ccctacctta cacgtctgct     1200

gattatcaac atgtgcttaa gccaacatcc gtctcttgag catggttttt agaggctacg     1260

aataaggcta tgaataaggg ttatctttaa gtcctaaggg attcctgggt gccactgctc     1320

tcttttcctc tacagctcca tcttgtttca cccaccccac atctcacaca tccagaattc     1380

ccttctttac tgatagtttc tgtgccaggt tctgggctaa accatggaga taaaaagaag     1440

agtaaaatac acttcccgac cttaaggatc tgatacatct agttattggt ctggaaattg     1500

gagaaatgga ggtgagcaaa ttaacggtag tgtgactgtg gctcaacttt ccatggtacg     1560

cgcgaattgt tctggaagtc acagatggga agacagaagc gcccctgagt gctttgtcat     1620

atagcacaga agtcctccac actgcctggg acagtgtcct gcatccacac agtaggtacc     1680

cagtaaaagt gttattaaat attgtcccag gagcccttag gagagtggtt taacatgaga     1740

aggcgccaac agcacacagg gtcagggtca cttctagaaa tagcccacca aggctattca     1800

gattggactg tggttccctt ctggacagtc acaccaggga cttcccagtg aacaaggggg     1860

cataggctcc tctctggatc ccaccttttc atcccttctg agaaatgtac cctattattt     1920

ccttcataaa gaatgccacc ca                                              1942


<210>  20
<211>  326
<212>  PRT
<213>  Homo sapiens

<400>  20

Met Ala Lys Met Glu Leu Ser Lys Ala Phe Ser Gly Gln Arg Thr Leu 
1               5                   10                  15      


Leu Ser Ala Ile Leu Ser Met Leu Ser Leu Ser Phe Ser Thr Thr Ser 
            20                  25                  30          


Leu Leu Ser Asn Tyr Trp Phe Val Gly Thr Gln Lys Val Pro Lys Pro 
        35                  40                  45              


Leu Cys Glu Lys Gly Leu Ala Ala Lys Cys Phe Asp Met Pro Val Ser 
    50                  55                  60                  


Leu Asp Gly Asp Thr Asn Thr Ser Thr Gln Glu Val Val Gln Tyr Asn 
65                  70                  75                  80  


Trp Glu Thr Gly Asp Asp Arg Phe Ser Phe Arg Ser Phe Arg Ser Gly 
                85                  90                  95      


Met Trp Leu Ser Cys Glu Glu Thr Val Glu Glu Pro Gly Glu Arg Cys 
            100                 105                 110         


Arg Ser Phe Ile Glu Leu Thr Pro Pro Ala Lys Arg Glu Ile Leu Trp 
        115                 120                 125             


Leu Ser Leu Gly Thr Gln Ile Thr Tyr Ile Gly Leu Gln Phe Ile Ser 
    130                 135                 140                 


Phe Leu Leu Leu Leu Thr Asp Leu Leu Leu Thr Gly Asn Pro Ala Cys 
145                 150                 155                 160 


Gly Leu Lys Leu Ser Ala Phe Ala Ala Val Ser Ser Val Leu Ser Gly 
                165                 170                 175     


Leu Leu Gly Met Val Ala His Met Met Tyr Ser Gln Val Phe Gln Ala 
            180                 185                 190         


Thr Val Asn Leu Gly Pro Glu Asp Trp Arg Pro His Val Trp Asn Tyr 
        195                 200                 205             


Gly Trp Ala Phe Tyr Met Ala Trp Leu Ser Phe Thr Cys Cys Met Ala 
    210                 215                 220                 


Ser Ala Val Thr Thr Phe Asn Thr Tyr Thr Arg Met Val Leu Glu Phe 
225                 230                 235                 240 


Lys Cys Lys His Ser Lys Ser Phe Lys Glu Asn Pro Asn Cys Leu Pro 
                245                 250                 255     


His His His Gln Cys Phe Pro Arg Arg Leu Ser Ser Ala Ala Pro Thr 
            260                 265                 270         


Val Gly Pro Leu Thr Ser Tyr His Gln Tyr His Asn Gln Pro Ile His 
        275                 280                 285             


Ser Val Ser Glu Gly Val Asp Phe Tyr Ser Glu Leu Arg Asn Lys Gly 
    290                 295                 300                 


Phe Gln Arg Gly Ala Ser Gln Glu Leu Lys Glu Ala Val Arg Ser Ser 
305                 310                 315                 320 


Val Glu Glu Glu Gln Cys 
                325     


<210>  21
<211>  2179
<212>  DNA
<213>  Homo sapiens

<400>  21
ggctggtgtc tggccctcag gacatcctct ccaatccacc acacaccacc ttacccctct       60

gctggcaaga ggggacctga ttcatcctca cgctaaacac tcattctacc caactgattg      120

agacagaaca gaagataaac tgaaacttct ctgccttccc gctgcaagag tgaatgagcg      180

atccctctca actgactcaa aatgtttgcc tcacccagga gatggagctc tcgaaggcct      240

tctctggcca gcggacactc ctatctgcca tcctcagcat gctatcactc agcttctcca      300

caacatccct gctcagcaac tactggtttg tgggcacaca gaaggtgccc aagcccctgt      360

gcgagaaagg tctggcagcc aagtgctttg acatgccagt gtccctggat ggagatacca      420

acacatccac ccaggaggtg gtacaataca actgggagac tggggatgac cggttctcct      480

tccggagctt ccggagtggc atgtggctat cctgtgagga aactgtggaa gaaccagcac      540

tgctccatcc ccagtcctgg aaacaattta gagcccttcg gtccagtggt acagcggcag      600

caaaagggga gaggtgccga agtttcattg aacttacacc accagccaag agaggtgaga      660

aaggactact ggaatttgcc acgttgcaag gcccatgtca ccccactctc cgatttggag      720

ggaagcggtt gatggagaag gcttccctcc cctcccctcc cttggggctt tgtggcaaaa      780

atcctatggt tatccctggg aacgcagatc acctacatcg gacttcaatt catcagcttc      840

ctcctgctac taacagactt gctactcact gggaaccctg cctgtgggct caaactgagc      900

gcctttgctg ctgtttcctc tgtcctgtca ggtctcctgg ggatggtggc ccacatgatg      960

tattcacaag tcttccaagc gactgtcaac ttgggtccag aagactggag accacatgtt     1020

tggaattatg gctgggcctt ctacatggcc tggctctcct tcacctgctg catggcgtcg     1080

gctgtcacca ccttcaacac gtacaccagg atggtgctgg agttcaagtg caagcatagt     1140

aagagcttca aggaaaaccc gaactgccta ccacatcacc atcagtgttt ccctcggcgg     1200

ctgtcaagtg cagcccccac cgtgggtcct ttgaccagct accaccagta tcataatcag     1260

cccatccact ctgtctctga gggagtcgac ttctactccg agctgcggaa caagggattt     1320

caaagagggg ccagccagga gctgaaagaa gcagttaggt catctgtaga ggaagagcag     1380

tgttaggagt taagcgggtt tggggagtag gcttgagccc taccttacac gtctgctgat     1440

tatcaacatg tgcttaagcc aacatccgtc tcttgagcat ggtttttaga ggctacgaat     1500

aaggctatga ataagggtta tctttaagtc ctaagggatt cctgggtgcc actgctctct     1560

tttcctctac agctccatct tgtttcaccc accccacatc tcacacatcc agaattccct     1620

tctttactga tagtttctgt gccaggttct gggctaaacc atggagataa aaagaagagt     1680

aaaatacact tcccgacctt aaggatctga tacatctagt tattggtctg gaaattggag     1740

aaatggaggt gagcaaatta acggtagtgt gactgtggct caactttcca tggtacgcgc     1800

gaattgttct ggaagtcaca gatgggaaga cagaagcgcc cctgagtgct ttgtcatata     1860

gcacagaagt cctccacact gcctgggaca gtgtcctgca tccacacagt aggtacccag     1920

taaaagtgtt attaaatatt gtcccaggag cccttaggag agtggtttaa catgagaagg     1980

cgccaacagc acacagggtc agggtcactt ctagaaatag cccaccaagg ctattcagat     2040

tggactgtgg ttcccttctg gacagtcaca ccagggactt cccagtgaac aagggggcat     2100

aggctcctct ctggatccca ccttttcatc ccttctgaga aatgtaccct attatttcct     2160

tcataaagaa tgccaccca                                                  2179


<210>  22
<211>  321
<212>  PRT
<213>  Homo sapiens

<400>  22

Met Ser Asp Pro Ser Gln Leu Thr Gln Asn Val Cys Leu Thr Gln Glu 
1               5                   10                  15      


Met Glu Leu Ser Lys Ala Phe Ser Gly Gln Arg Thr Leu Leu Ser Ala 
            20                  25                  30          


Ile Leu Ser Met Leu Ser Leu Ser Phe Ser Thr Thr Ser Leu Leu Ser 
        35                  40                  45              


Asn Tyr Trp Phe Val Gly Thr Gln Lys Val Pro Lys Pro Leu Cys Glu 
    50                  55                  60                  


Lys Gly Leu Ala Ala Lys Cys Phe Asp Met Pro Val Ser Leu Asp Gly 
65                  70                  75                  80  


Asp Thr Asn Thr Ser Thr Gln Glu Val Val Gln Tyr Asn Trp Glu Thr 
                85                  90                  95      


Gly Asp Asp Arg Phe Ser Phe Arg Ser Phe Arg Ser Gly Met Trp Leu 
            100                 105                 110         


Ser Cys Glu Glu Thr Val Glu Glu Pro Ala Leu Leu His Pro Gln Ser 
        115                 120                 125             


Trp Lys Gln Phe Arg Ala Leu Arg Ser Ser Gly Thr Ala Ala Ala Lys 
    130                 135                 140                 


Gly Glu Arg Cys Arg Ser Phe Ile Glu Leu Thr Pro Pro Ala Lys Arg 
145                 150                 155                 160 


Gly Glu Lys Gly Leu Leu Glu Phe Ala Thr Leu Gln Gly Pro Cys His 
                165                 170                 175     


Pro Thr Leu Arg Phe Gly Gly Lys Arg Leu Met Glu Lys Ala Ser Leu 
            180                 185                 190         


Pro Ser Pro Pro Leu Gly Leu Cys Gly Lys Asn Pro Met Val Ile Pro 
        195                 200                 205             


Gly Asn Ala Asp His Leu His Arg Thr Ser Ile His Gln Leu Pro Pro 
    210                 215                 220                 


Ala Thr Asn Arg Leu Ala Thr His Trp Glu Pro Cys Leu Trp Ala Gln 
225                 230                 235                 240 


Thr Glu Arg Leu Cys Cys Cys Phe Leu Cys Pro Val Arg Ser Pro Gly 
                245                 250                 255     


Asp Gly Gly Pro His Asp Val Phe Thr Ser Leu Pro Ser Asp Cys Gln 
            260                 265                 270         


Leu Gly Ser Arg Arg Leu Glu Thr Thr Cys Leu Glu Leu Trp Leu Gly 
        275                 280                 285             


Leu Leu His Gly Leu Ala Leu Leu His Leu Leu His Gly Val Gly Cys 
    290                 295                 300                 


His His Leu Gln His Val His Gln Asp Gly Ala Gly Val Gln Val Gln 
305                 310                 315                 320 


Ala 
    


<210>  23
<211>  2055
<212>  DNA
<213>  Homo sapiens

<400>  23
ggctggtgtc tggccctcag gacatcctct ccaatccacc acacaccacc ttacccctct       60

gctggcaaga ggggacctga ttcatcctca cgctaaacac tcattctacc caactgattg      120

agacagaaca gaagataaac tgaaacttct ctgccttccc gctgcaagag tgaatgagcg      180

atccctctca actgactcaa aatgtttgcc tcacccagga gatggagctc tcgaaggcct      240

tctctggcca gcggacactc ctatctgcca tcctcagcat gctatcactc agcttctcca      300

caacatccct gctcagcaac tactggtttg tgggcacaca gaaggtgccc aagcccctgt      360

gcgagaaagg tctggcagcc aagtgctttg acatgccagt gtccctggat ggagatacca      420

acacatccac ccaggaggtg gtacaataca actgggagac tggggatgac cggttctcct      480

tccggagctt ccggagtggc atgtggctat cctgtgagga aactgtggaa gaaccagcac      540

tgctccatcc ccagtcctgg aaacaattta gagcccttcg gtccagtggt acagcggcag      600

caaaagggga gaggtgccga agtttcattg aacttacacc accagccaag agagaaatcc      660

tatggttatc cctgggaacg cagatcacct acatcggact tcaattcatc agcttcctcc      720

tgctactaac agacttgcta ctcactggga accctgcctg tgggctcaaa ctgagcgcct      780

ttgctgctgt ttcctctgtc ctgtcaggtc tcctggggat ggtggcccac atgatgtatt      840

cacaagtctt ccaagcgact gtcaacttgg gtccagaaga ctggagacca catgtttgga      900

attatggctg ggccttctac atggcctggc tctccttcac ctgctgcatg gcgtcggctg      960

tcaccacctt caacacgtac accaggatgg tgctggagtt caagtgcaag catagtaaga     1020

gcttcaagga aaacccgaac tgcctaccac atcaccatca gtgtttccct cggcggctgt     1080

caagtgcagc ccccaccgtg ggtcctttga ccagctacca ccagtatcat aatcagccca     1140

tccactctgt ctctgaggga gtcgacttct actccgagct gcggaacaag ggatttcaaa     1200

gaggggccag ccaggagctg aaagaagcag ttaggtcatc tgtagaggaa gagcagtgtt     1260

aggagttaag cgggtttggg gagtaggctt gagccctacc ttacacgtct gctgattatc     1320

aacatgtgct taagccaaca tccgtctctt gagcatggtt tttagaggct acgaataagg     1380

ctatgaataa gggttatctt taagtcctaa gggattcctg ggtgccactg ctctcttttc     1440

ctctacagct ccatcttgtt tcacccaccc cacatctcac acatccagaa ttcccttctt     1500

tactgatagt ttctgtgcca ggttctgggc taaaccatgg agataaaaag aagagtaaaa     1560

tacacttccc gaccttaagg atctgataca tctagttatt ggtctggaaa ttggagaaat     1620

ggaggtgagc aaattaacgg tagtgtgact gtggctcaac tttccatggt acgcgcgaat     1680

tgttctggaa gtcacagatg ggaagacaga agcgcccctg agtgctttgt catatagcac     1740

agaagtcctc cacactgcct gggacagtgt cctgcatcca cacagtaggt acccagtaaa     1800

agtgttatta aatattgtcc caggagccct taggagagtg gtttaacatg agaaggcgcc     1860

aacagcacac agggtcaggg tcacttctag aaatagccca ccaaggctat tcagattgga     1920

ctgtggttcc cttctggaca gtcacaccag ggacttccca gtgaacaagg gggcataggc     1980

tcctctctgg atcccacctt ttcatccctt ctgagaaatg taccctatta tttccttcat     2040

aaagaatgcc accca                                                      2055


<210>  24
<211>  362
<212>  PRT
<213>  Homo sapiens

<400>  24

Met Ser Asp Pro Ser Gln Leu Thr Gln Asn Val Cys Leu Thr Gln Glu 
1               5                   10                  15      


Met Glu Leu Ser Lys Ala Phe Ser Gly Gln Arg Thr Leu Leu Ser Ala 
            20                  25                  30          


Ile Leu Ser Met Leu Ser Leu Ser Phe Ser Thr Thr Ser Leu Leu Ser 
        35                  40                  45              


Asn Tyr Trp Phe Val Gly Thr Gln Lys Val Pro Lys Pro Leu Cys Glu 
    50                  55                  60                  


Lys Gly Leu Ala Ala Lys Cys Phe Asp Met Pro Val Ser Leu Asp Gly 
65                  70                  75                  80  


Asp Thr Asn Thr Ser Thr Gln Glu Val Val Gln Tyr Asn Trp Glu Thr 
                85                  90                  95      


Gly Asp Asp Arg Phe Ser Phe Arg Ser Phe Arg Ser Gly Met Trp Leu 
            100                 105                 110         


Ser Cys Glu Glu Thr Val Glu Glu Pro Ala Leu Leu His Pro Gln Ser 
        115                 120                 125             


Trp Lys Gln Phe Arg Ala Leu Arg Ser Ser Gly Thr Ala Ala Ala Lys 
    130                 135                 140                 


Gly Glu Arg Cys Arg Ser Phe Ile Glu Leu Thr Pro Pro Ala Lys Arg 
145                 150                 155                 160 


Glu Ile Leu Trp Leu Ser Leu Gly Thr Gln Ile Thr Tyr Ile Gly Leu 
                165                 170                 175     


Gln Phe Ile Ser Phe Leu Leu Leu Leu Thr Asp Leu Leu Leu Thr Gly 
            180                 185                 190         


Asn Pro Ala Cys Gly Leu Lys Leu Ser Ala Phe Ala Ala Val Ser Ser 
        195                 200                 205             


Val Leu Ser Gly Leu Leu Gly Met Val Ala His Met Met Tyr Ser Gln 
    210                 215                 220                 


Val Phe Gln Ala Thr Val Asn Leu Gly Pro Glu Asp Trp Arg Pro His 
225                 230                 235                 240 


Val Trp Asn Tyr Gly Trp Ala Phe Tyr Met Ala Trp Leu Ser Phe Thr 
                245                 250                 255     


Cys Cys Met Ala Ser Ala Val Thr Thr Phe Asn Thr Tyr Thr Arg Met 
            260                 265                 270         


Val Leu Glu Phe Lys Cys Lys His Ser Lys Ser Phe Lys Glu Asn Pro 
        275                 280                 285             


Asn Cys Leu Pro His His His Gln Cys Phe Pro Arg Arg Leu Ser Ser 
    290                 295                 300                 


Ala Ala Pro Thr Val Gly Pro Leu Thr Ser Tyr His Gln Tyr His Asn 
305                 310                 315                 320 


Gln Pro Ile His Ser Val Ser Glu Gly Val Asp Phe Tyr Ser Glu Leu 
                325                 330                 335     


Arg Asn Lys Gly Phe Gln Arg Gly Ala Ser Gln Glu Leu Lys Glu Ala 
            340                 345                 350         


Val Arg Ser Ser Val Glu Glu Glu Gln Cys 
        355                 360         


<210>  25
<211>  3183
<212>  DNA
<213>  Homo sapiens

<400>  25
cgaggctcct cctctgtgga tggtcactgc ccctccacca ggcttcctgc tggaggagtt       60

tccttcccag ccaggccggc ccagaagcca gatggtcccg ggacaggccc agccccagag      120

cccagagatg ctgctgctgc ccctgctgct gcccgtgctg ggggcggggt ccctgaacaa      180

ggatcccagt tacagtcttc aagtgcagag gcaggtgccg gtgccggagg gcctgtgtgt      240

catcgtgtct tgcaacctct cctacccccg ggatggctgg gacgagtcta ctgctgctta      300

tggctactgg ttcaaaggac ggaccagccc aaagacgggt gctcctgtgg ccactaacaa      360

ccagagtcga gaggtggaaa tgagcacccg ggaccgattc cagctcactg gggatcccgg      420

caaagggagc tgctccttgg tgatcagaga cgcgcagagg gaggatgagg catggtactt      480

ctttcgggtg gagagaggaa gccgtgtgag acatagtttc ctgagcaatg cgttctttct      540

aaaagtaaca gccctgacta agaagcctga tgtctacatc cccgagaccc tggagcccgg      600

gcagccggtg acggtcatct gtgtgtttaa ctgggctttc aagaaatgtc cagccccttc      660

tttctcctgg acgggggctg ccctctcccc tagaagaacc agaccaagca cctcccactt      720

ctcagtgctc agcttcacgc ccagccccca ggaccacgac accgacctca cctgccatgt      780

ggacttctcc agaaagggtg tgagcgcaca gaggaccgtc cgactccgtg tggcctatgc      840

ccccaaagac cttattatca gcatttcaca tgacaacacg tcagccctgg aactccaggg      900

aaacgtcata tatctggaag ttcagaaagg ccagttcctg cggctcctct gtgctgctga      960

cagccagccc cctgccacgc tgagctgggt cctgcaggac agagtcctct cctcgtccca     1020

cccctggggc cccagaaccc tggggctgga gctgcgtggg gtaagggccg gggattcagg     1080

gcgctacacc tgccgagcgg agaacaggct tggctcccag cagcaagccc tggacctctc     1140

tgtgcagtat cctccagaga acctgagagt gatggtttcc caagcaaaca ggacagtcct     1200

ggaaaacctc gggaacggca catccctccc ggtcctggag ggccaaagcc tgcgcctggt     1260

ctgtgtcacc cacagcagcc ccccagccag gctgagctgg acccggtggg gacagaccgt     1320

gggcccctcc cagccctcag accccggggt cctggagctg ccacccattc aaatggagca     1380

cgaaggagag ttcacctgcc acgctcagca ccctctgggc tcccagcacg tctctctcag     1440

cctctccgtg cactaccctc cacagctgct gggcccctcc tgctcctggg aggctgaggg     1500

tctgcactgc agctgctcct cccaggccag cccggccccc tctctgcgct ggtggcttgg     1560

ggaggagctg ctggagggga acagcagtca gggctccttc gaggtcaccc ccagctcagc     1620

cgggccctgg gccaacagct ccctgagcct ccatggaggg ctcagctccg gcctcaggct     1680

ccgctgtaag gcctggaacg tccacggggc ccagagtggc tctgtcttcc agctgctacc     1740

agggaagctg gagcatgggg gaggacttgg cctgggggct gccctgggag ctggcgtcgc     1800

tgccctgctc gctttctgtt cctgccttgt cgtcttcagg gtgaagatct gcaggaagga     1860

agctcgcaag agggcagcag ctgagcagga cgtgccctcc accctgggac ccatctccca     1920

gggtcaccag catgaatgct cggcaggcag ctcccaagac cacccgcccc caggtgcagc     1980

cacctacacc ccggggaagg gggaagagca ggagctccac tatgcctccc tcagcttcca     2040

gggcctgagg ctctgggagc ctgcggacca ggaggccccc agcaccaccg agtactcgga     2100

gatcaagatc cacacaggac agcccctgag gggcccaggc tttgggcttc aattggagag     2160

ggagatgtca gggatggttc caaagtgaag aggtctccat ggcaacagga caccagcaag     2220

tgtgtgggag tcgcactggt gtgacggcca gaactggact cagatttcag ccccatcccc     2280

aatgaagagc ttgagtttga agattatact ttttttgaga cagggtctga ctctgtcctc     2340

caggccagag tccagtggtg caatctcagc tcactgtagc ctcaacctgc caggttgaag     2400

tgagcctccc atttcagcct cccaagtagc tgggactaca attgtgagcc accatgccag     2460

gctcattgtt atatttttag tagagacagg gttttgccat gtttccctgg ctggtctcag     2520

actcctgggc tcaagcaatc tgcccgcctc tgcctcccaa agtgctggga ttacagacgt     2580

gagccaccac agctggctga agattatact ttcaattcag agcgagtttg aagatgacac     2640

tttgaggcat cgtgtctatg gttcattact acagaagctt ctctggatgt gtaaagcaca     2700

ggaaaccagg cagaggaggc acagggtgct ctccagaacg agaagccagc tcctggagtt     2760

gtttgctgca actgccattc cccgttgatg accatgctct tccttcagaa gagggagagt     2820

gagaggacca agtccaagtg gttcccattt gaacatttaa aaaaaaaaaa aaggctgggc     2880

atggtggctc acgcctgtaa tctcaacact ttgggaggct gaagtgggtg gatcacaagt     2940

caggagttca agaccagcct gggcaagatg gtgaaacccc atctctacta aaaatacaaa     3000

aattagccgg gcatggtggc gggcgcctaa aatcccagct actcgggaga ctaggcagag     3060

aattggttga acccgggagg tggaggttgc agtgagccga gatcgtccca ctgcactcca     3120

gcctgggcaa cagagtgaga ctctgtttct aaataaataa atgaaaaaaa aaaaaaaaaa     3180

aaa                                                                   3183


<210>  26
<211>  698
<212>  PRT
<213>  Homo sapiens

<400>  26

Met Val Pro Gly Gln Ala Gln Pro Gln Ser Pro Glu Met Leu Leu Leu 
1               5                   10                  15      


Pro Leu Leu Leu Pro Val Leu Gly Ala Gly Ser Leu Asn Lys Asp Pro 
            20                  25                  30          


Ser Tyr Ser Leu Gln Val Gln Arg Gln Val Pro Val Pro Glu Gly Leu 
        35                  40                  45              


Cys Val Ile Val Ser Cys Asn Leu Ser Tyr Pro Arg Asp Gly Trp Asp 
    50                  55                  60                  


Glu Ser Thr Ala Ala Tyr Gly Tyr Trp Phe Lys Gly Arg Thr Ser Pro 
65                  70                  75                  80  


Lys Thr Gly Ala Pro Val Ala Thr Asn Asn Gln Ser Arg Glu Val Glu 
                85                  90                  95      


Met Ser Thr Arg Asp Arg Phe Gln Leu Thr Gly Asp Pro Gly Lys Gly 
            100                 105                 110         


Ser Cys Ser Leu Val Ile Arg Asp Ala Gln Arg Glu Asp Glu Ala Trp 
        115                 120                 125             


Tyr Phe Phe Arg Val Glu Arg Gly Ser Arg Val Arg His Ser Phe Leu 
    130                 135                 140                 


Ser Asn Ala Phe Phe Leu Lys Val Thr Ala Leu Thr Lys Lys Pro Asp 
145                 150                 155                 160 


Val Tyr Ile Pro Glu Thr Leu Glu Pro Gly Gln Pro Val Thr Val Ile 
                165                 170                 175     


Cys Val Phe Asn Trp Ala Phe Lys Lys Cys Pro Ala Pro Ser Phe Ser 
            180                 185                 190         


Trp Thr Gly Ala Ala Leu Ser Pro Arg Arg Thr Arg Pro Ser Thr Ser 
        195                 200                 205             


His Phe Ser Val Leu Ser Phe Thr Pro Ser Pro Gln Asp His Asp Thr 
    210                 215                 220                 


Asp Leu Thr Cys His Val Asp Phe Ser Arg Lys Gly Val Ser Ala Gln 
225                 230                 235                 240 


Arg Thr Val Arg Leu Arg Val Ala Tyr Ala Pro Lys Asp Leu Ile Ile 
                245                 250                 255     


Ser Ile Ser His Asp Asn Thr Ser Ala Leu Glu Leu Gln Gly Asn Val 
            260                 265                 270         


Ile Tyr Leu Glu Val Gln Lys Gly Gln Phe Leu Arg Leu Leu Cys Ala 
        275                 280                 285             


Ala Asp Ser Gln Pro Pro Ala Thr Leu Ser Trp Val Leu Gln Asp Arg 
    290                 295                 300                 


Val Leu Ser Ser Ser His Pro Trp Gly Pro Arg Thr Leu Gly Leu Glu 
305                 310                 315                 320 


Leu Arg Gly Val Arg Ala Gly Asp Ser Gly Arg Tyr Thr Cys Arg Ala 
                325                 330                 335     


Glu Asn Arg Leu Gly Ser Gln Gln Gln Ala Leu Asp Leu Ser Val Gln 
            340                 345                 350         


Tyr Pro Pro Glu Asn Leu Arg Val Met Val Ser Gln Ala Asn Arg Thr 
        355                 360                 365             


Val Leu Glu Asn Leu Gly Asn Gly Thr Ser Leu Pro Val Leu Glu Gly 
    370                 375                 380                 


Gln Ser Leu Arg Leu Val Cys Val Thr His Ser Ser Pro Pro Ala Arg 
385                 390                 395                 400 


Leu Ser Trp Thr Arg Trp Gly Gln Thr Val Gly Pro Ser Gln Pro Ser 
                405                 410                 415     


Asp Pro Gly Val Leu Glu Leu Pro Pro Ile Gln Met Glu His Glu Gly 
            420                 425                 430         


Glu Phe Thr Cys His Ala Gln His Pro Leu Gly Ser Gln His Val Ser 
        435                 440                 445             


Leu Ser Leu Ser Val His Tyr Pro Pro Gln Leu Leu Gly Pro Ser Cys 
    450                 455                 460                 


Ser Trp Glu Ala Glu Gly Leu His Cys Ser Cys Ser Ser Gln Ala Ser 
465                 470                 475                 480 


Pro Ala Pro Ser Leu Arg Trp Trp Leu Gly Glu Glu Leu Leu Glu Gly 
                485                 490                 495     


Asn Ser Ser Gln Gly Ser Phe Glu Val Thr Pro Ser Ser Ala Gly Pro 
            500                 505                 510         


Trp Ala Asn Ser Ser Leu Ser Leu His Gly Gly Leu Ser Ser Gly Leu 
        515                 520                 525             


Arg Leu Arg Cys Lys Ala Trp Asn Val His Gly Ala Gln Ser Gly Ser 
    530                 535                 540                 


Val Phe Gln Leu Leu Pro Gly Lys Leu Glu His Gly Gly Gly Leu Gly 
545                 550                 555                 560 


Leu Gly Ala Ala Leu Gly Ala Gly Val Ala Ala Leu Leu Ala Phe Cys 
                565                 570                 575     


Ser Cys Leu Val Val Phe Arg Val Lys Ile Cys Arg Lys Glu Ala Arg 
            580                 585                 590         


Lys Arg Ala Ala Ala Glu Gln Asp Val Pro Ser Thr Leu Gly Pro Ile 
        595                 600                 605             


Ser Gln Gly His Gln His Glu Cys Ser Ala Gly Ser Ser Gln Asp His 
    610                 615                 620                 


Pro Pro Pro Gly Ala Ala Thr Tyr Thr Pro Gly Lys Gly Glu Glu Gln 
625                 630                 635                 640 


Glu Leu His Tyr Ala Ser Leu Ser Phe Gln Gly Leu Arg Leu Trp Glu 
                645                 650                 655     


Pro Ala Asp Gln Glu Ala Pro Ser Thr Thr Glu Tyr Ser Glu Ile Lys 
            660                 665                 670         


Ile His Thr Gly Gln Pro Leu Arg Gly Pro Gly Phe Gly Leu Gln Leu 
        675                 680                 685             


Glu Arg Glu Met Ser Gly Met Val Pro Lys 
    690                 695             


<210>  27
<211>  2895
<212>  DNA
<213>  Homo sapiens

<400>  27
cgaggctcct cctctgtgga tggtcactgc ccctccacca ggcttcctgc tggaggagtt       60

tccttcccag ccaggccggc ccagaagcca gatggtcccg ggacaggccc agccccagag      120

cccagagatg ctgctgctgc ccctgctgct gcccgtgctg ggggcggggt ccctgaacaa      180

ggatcccagt tacagtcttc aagtgcagag gcaggtgccg gtgccggagg gcctgtgtgt      240

catcgtgtct tgcaacctct cctacccccg ggatggctgg gacgagtcta ctgctgctta      300

tggctactgg ttcaaaggac ggaccagccc aaagacgggt gctcctgtgg ccactaacaa      360

ccagagtcga gaggtggaaa tgagcacccg ggaccgattc cagctcactg gggatcccgg      420

caaagggagc tgctccttgg tgatcagaga cgcgcagagg gaggatgagg catggtactt      480

ctttcgggtg gagagaggaa gccgtgtgag acatagtttc ctgagcaatg cgttctttct      540

aaaagtaaca gccctgacta agaagcctga tgtctacatc cccgagaccc tggagcccgg      600

gcagccggtg acggtcatct gtgtgtttaa ctgggctttc aagaaatgtc cagccccttc      660

tttctcctgg acgggggctg ccctctcccc tagaagaacc agaccaagca cctcccactt      720

ctcagtgctc agcttcacgc ccagccccca ggaccacgac accgacctca cctgccatgt      780

ggacttctcc agaaagggtg tgagcgcaca gaggaccgtc cgactccgtg tggcctatgc      840

ccccaaagac cttattatca gcatttcaca tgacaacacg tcagccctgg aactccaggg      900

aaacgtcata tatctggaag ttcagaaagg ccagttcctg cggctcctct gtgctgctga      960

cagccagccc cctgccacgc tgagctgggt cctgcaggac agagtcctct cctcgtccca     1020

cccctggggc cccagaaccc tggggctgga gctgcgtggg gtaagggccg gggattcagg     1080

gcgctacacc tgccgagcgg agaacaggct tggctcccag cagcaagccc tggacctctc     1140

tgtgcagtat cctccagaga acctgagagt gatggtttcc caagcaaaca ggacagtcct     1200

ggaaaacctc gggaacggca catccctccc ggtcctggag ggccaaagcc tgcgcctggt     1260

ctgtgtcacc cacagcagcc ccccagccag gctgagctgg acccggtggg gacagaccgt     1320

gggcccctcc cagccctcag accccggggt cctggagctg ccacccattc aaatggagca     1380

cgaaggagag ttcacctgcc acgctcagca ccctctgggc tcccagcacg tctctctcag     1440

cctctccgtg cactggaagc tggagcatgg gggaggactt ggcctggggg ctgccctggg     1500

agctggcgtc gctgccctgc tcgctttctg ttcctgcctt gtcgtcttca gggtgaagat     1560

ctgcaggaag gaagctcgca agagggcagc agctgagcag gacgtgccct ccaccctggg     1620

acccatctcc cagggtcacc agcatgaatg ctcggcaggc agctcccaag accacccgcc     1680

cccaggtgca gccacctaca ccccggggaa gggggaagag caggagctcc actatgcctc     1740

cctcagcttc cagggcctga ggctctggga gcctgcggac caggaggccc ccagcaccac     1800

cgagtactcg gagatcaaga tccacacagg acagcccctg aggggcccag gctttgggct     1860

tcaattggag agggagatgt cagggatggt tccaaagtga agaggtctcc atggcaacag     1920

gacaccagca agtgtgtggg agtcgcactg gtgtgacggc cagaactgga ctcagatttc     1980

agccccatcc ccaatgaaga gcttgagttt gaagattata ctttttttga gacagggtct     2040

gactctgtcc tccaggccag agtccagtgg tgcaatctca gctcactgta gcctcaacct     2100

gccaggttga agtgagcctc ccatttcagc ctcccaagta gctgggacta caattgtgag     2160

ccaccatgcc aggctcattg ttatattttt agtagagaca gggttttgcc atgtttccct     2220

ggctggtctc agactcctgg gctcaagcaa tctgcccgcc tctgcctccc aaagtgctgg     2280

gattacagac gtgagccacc acagctggct gaagattata ctttcaattc agagcgagtt     2340

tgaagatgac actttgaggc atcgtgtcta tggttcatta ctacagaagc ttctctggat     2400

gtgtaaagca caggaaacca ggcagaggag gcacagggtg ctctccagaa cgagaagcca     2460

gctcctggag ttgtttgctg caactgccat tccccgttga tgaccatgct cttccttcag     2520

aagagggaga gtgagaggac caagtccaag tggttcccat ttgaacattt aaaaaaaaaa     2580

aaaaggctgg gcatggtggc tcacgcctgt aatctcaaca ctttgggagg ctgaagtggg     2640

tggatcacaa gtcaggagtt caagaccagc ctgggcaaga tggtgaaacc ccatctctac     2700

taaaaataca aaaattagcc gggcatggtg gcgggcgcct aaaatcccag ctactcggga     2760

gactaggcag agaattggtt gaacccggga ggtggaggtt gcagtgagcc gagatcgtcc     2820

cactgcactc cagcctgggc aacagagtga gactctgttt ctaaataaat aaatgaaaaa     2880

aaaaaaaaaa aaaaa                                                      2895


<210>  28
<211>  602
<212>  PRT
<213>  Homo sapiens

<400>  28

Met Val Pro Gly Gln Ala Gln Pro Gln Ser Pro Glu Met Leu Leu Leu 
1               5                   10                  15      


Pro Leu Leu Leu Pro Val Leu Gly Ala Gly Ser Leu Asn Lys Asp Pro 
            20                  25                  30          


Ser Tyr Ser Leu Gln Val Gln Arg Gln Val Pro Val Pro Glu Gly Leu 
        35                  40                  45              


Cys Val Ile Val Ser Cys Asn Leu Ser Tyr Pro Arg Asp Gly Trp Asp 
    50                  55                  60                  


Glu Ser Thr Ala Ala Tyr Gly Tyr Trp Phe Lys Gly Arg Thr Ser Pro 
65                  70                  75                  80  


Lys Thr Gly Ala Pro Val Ala Thr Asn Asn Gln Ser Arg Glu Val Glu 
                85                  90                  95      


Met Ser Thr Arg Asp Arg Phe Gln Leu Thr Gly Asp Pro Gly Lys Gly 
            100                 105                 110         


Ser Cys Ser Leu Val Ile Arg Asp Ala Gln Arg Glu Asp Glu Ala Trp 
        115                 120                 125             


Tyr Phe Phe Arg Val Glu Arg Gly Ser Arg Val Arg His Ser Phe Leu 
    130                 135                 140                 


Ser Asn Ala Phe Phe Leu Lys Val Thr Ala Leu Thr Lys Lys Pro Asp 
145                 150                 155                 160 


Val Tyr Ile Pro Glu Thr Leu Glu Pro Gly Gln Pro Val Thr Val Ile 
                165                 170                 175     


Cys Val Phe Asn Trp Ala Phe Lys Lys Cys Pro Ala Pro Ser Phe Ser 
            180                 185                 190         


Trp Thr Gly Ala Ala Leu Ser Pro Arg Arg Thr Arg Pro Ser Thr Ser 
        195                 200                 205             


His Phe Ser Val Leu Ser Phe Thr Pro Ser Pro Gln Asp His Asp Thr 
    210                 215                 220                 


Asp Leu Thr Cys His Val Asp Phe Ser Arg Lys Gly Val Ser Ala Gln 
225                 230                 235                 240 


Arg Thr Val Arg Leu Arg Val Ala Tyr Ala Pro Lys Asp Leu Ile Ile 
                245                 250                 255     


Ser Ile Ser His Asp Asn Thr Ser Ala Leu Glu Leu Gln Gly Asn Val 
            260                 265                 270         


Ile Tyr Leu Glu Val Gln Lys Gly Gln Phe Leu Arg Leu Leu Cys Ala 
        275                 280                 285             


Ala Asp Ser Gln Pro Pro Ala Thr Leu Ser Trp Val Leu Gln Asp Arg 
    290                 295                 300                 


Val Leu Ser Ser Ser His Pro Trp Gly Pro Arg Thr Leu Gly Leu Glu 
305                 310                 315                 320 


Leu Arg Gly Val Arg Ala Gly Asp Ser Gly Arg Tyr Thr Cys Arg Ala 
                325                 330                 335     


Glu Asn Arg Leu Gly Ser Gln Gln Gln Ala Leu Asp Leu Ser Val Gln 
            340                 345                 350         


Tyr Pro Pro Glu Asn Leu Arg Val Met Val Ser Gln Ala Asn Arg Thr 
        355                 360                 365             


Val Leu Glu Asn Leu Gly Asn Gly Thr Ser Leu Pro Val Leu Glu Gly 
    370                 375                 380                 


Gln Ser Leu Arg Leu Val Cys Val Thr His Ser Ser Pro Pro Ala Arg 
385                 390                 395                 400 


Leu Ser Trp Thr Arg Trp Gly Gln Thr Val Gly Pro Ser Gln Pro Ser 
                405                 410                 415     


Asp Pro Gly Val Leu Glu Leu Pro Pro Ile Gln Met Glu His Glu Gly 
            420                 425                 430         


Glu Phe Thr Cys His Ala Gln His Pro Leu Gly Ser Gln His Val Ser 
        435                 440                 445             


Leu Ser Leu Ser Val His Trp Lys Leu Glu His Gly Gly Gly Leu Gly 
    450                 455                 460                 


Leu Gly Ala Ala Leu Gly Ala Gly Val Ala Ala Leu Leu Ala Phe Cys 
465                 470                 475                 480 


Ser Cys Leu Val Val Phe Arg Val Lys Ile Cys Arg Lys Glu Ala Arg 
                485                 490                 495     


Lys Arg Ala Ala Ala Glu Gln Asp Val Pro Ser Thr Leu Gly Pro Ile 
            500                 505                 510         


Ser Gln Gly His Gln His Glu Cys Ser Ala Gly Ser Ser Gln Asp His 
        515                 520                 525             


Pro Pro Pro Gly Ala Ala Thr Tyr Thr Pro Gly Lys Gly Glu Glu Gln 
    530                 535                 540                 


Glu Leu His Tyr Ala Ser Leu Ser Phe Gln Gly Leu Arg Leu Trp Glu 
545                 550                 555                 560 


Pro Ala Asp Gln Glu Ala Pro Ser Thr Thr Glu Tyr Ser Glu Ile Lys 
                565                 570                 575     


Ile His Thr Gly Gln Pro Leu Arg Gly Pro Gly Phe Gly Leu Gln Leu 
            580                 585                 590         


Glu Arg Glu Met Ser Gly Met Val Pro Lys 
        595                 600         


