                         SEQUENCE LISTING

<110>  Towne, Jennifer
       Cheng, Janet
       O'Neill, Jason
       Zhang, Yu
       Sun, Yu
       Cerne, Heather
       Piper, Derek
       Ketchem, Randal
 
<120>  HUMAN IL-23 ANTIGEN BINDING PROTEINS

<130>  A-1529-WO-PCT

<140>  to be assigned
<141>  2010-10-26

<150>  61/381,287
<151>  2010-09-09

<150>  61/254,982
<151>  2009-10-26

<160>  155   

<170>  PatentIn version 3.5

<210>  1
<211>  111
<212>  PRT
<213>  Homo sapiens

<400>  1

Gln Ser Val Leu Thr Gln Pro Pro Ser Val Ser Gly Ala Pro Gly Gln 
1               5                   10                  15      


Arg Val Thr Ile Ser Cys Thr Gly Ser Ser Ser Asn Thr Gly Ala Gly 
            20                  25                  30          


Tyr Asp Val His Trp Tyr Gln Gln Val Pro Gly Thr Ala Pro Lys Leu 
        35                  40                  45              


Leu Ile Tyr Gly Ser Gly Asn Arg Pro Ser Gly Val Pro Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Thr Gly Leu 
65                  70                  75                  80  


Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Gln Ser Tyr Asp Ser Ser 
                85                  90                  95      


Leu Ser Gly Trp Val Phe Gly Gly Gly Thr Arg Leu Thr Val Leu 
            100                 105                 110     


<210>  2
<211>  333
<212>  DNA
<213>  Homo sapiens

<400>  2
cagtctgtgc tgacgcagcc gccctcagtg tctggggccc cagggcagag ggtcaccatc       60

tcctgcactg ggagcagctc caacaccggg gcaggttatg atgtacactg gtaccagcaa      120

gttccaggaa cagcccccaa actcctcatt tatggtagcg gcaatcggcc ctcaggggtc      180

cctgaccgat tctctggctc caagtctggc acctcagcct ccctggccat cactggactc      240

caggctgagg atgaggctga ttattactgc cagtcctatg acagcagcct gagtggttgg      300

gtgttcggcg gagggaccag gctgaccgtc ctg                                   333


<210>  3
<211>  111
<212>  PRT
<213>  Homo sapiens

<400>  3

Gln Ser Val Leu Thr Gln Pro Pro Ser Val Ser Gly Ala Pro Gly Gln 
1               5                   10                  15      


Arg Val Thr Ile Ser Cys Thr Gly Ser Ser Ser Asn Ile Gly Ala Gly 
            20                  25                  30          


Tyr Asp Val His Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu 
        35                  40                  45              


Leu Ile Tyr Gly Ser Asn Asn Arg Pro Ser Gly Val Pro Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Thr Gly Leu 
65                  70                  75                  80  


Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Gln Ser Tyr Asp Ser Ser 
                85                  90                  95      


Leu Ser Gly Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 110     


<210>  4
<211>  115
<212>  PRT
<213>  Homo sapiens

<400>  4

Gln Ala Val Leu Thr Gln Pro Ser Ser Leu Ser Ala Ser Pro Gly Ala 
1               5                   10                  15      


Ser Ala Ser Leu Thr Cys Thr Leu Arg Ser Gly Ile Asn Val Gly Thr 
            20                  25                  30          


Tyr Arg Ile Tyr Trp Tyr Gln Gln Lys Pro Gly Ser Pro Pro Gln Tyr 
        35                  40                  45              


Leu Leu Arg Tyr Lys Ser Asp Ser Asp Lys Gln Gln Gly Ser Gly Val 
    50                  55                  60                  


Pro Ser Arg Phe Ser Gly Ser Lys Asp Ala Ser Ala Asn Ala Gly Ile 
65                  70                  75                  80  


Leu Leu Ile Ser Gly Leu Gln Ser Glu Asp Glu Ala Asp Tyr Tyr Cys 
                85                  90                  95      


Met Ile Trp His Ser Ser Ala Ser Val Phe Gly Gly Gly Thr Lys Leu 
            100                 105                 110         


Thr Val Leu 
        115 


<210>  5
<211>  345
<212>  DNA
<213>  Homo sapiens

<400>  5
caggctgtgc tgactcagcc gtcttccctc tctgcatctc ctggagcatc agccagtctc       60

acctgcacct tacgcagtgg catcaatgtt ggtacctaca ggatatactg gtaccagcag      120

aagccaggga gtcctcccca gtatctcctg aggtacaaat cagactcaga taagcagcag      180

ggctctggag tccccagccg cttctctgga tccaaagatg cttcggccaa tgcagggatt      240

ttactcatct ctgggctcca gtctgaggat gaggctgact attactgtat gatttggcac      300

agcagcgctt cggtattcgg cggagggacc aagctgaccg tccta                      345


<210>  6
<211>  14
<212>  PRT
<213>  Homo sapiens

<400>  6

Glu Asn Thr Val Thr Ile Tyr Tyr Asn Tyr Gly Met Asp Val 
1               5                   10                  


<210>  7
<211>  116
<212>  PRT
<213>  Homo sapiens

<400>  7

Gln Pro Val Leu Thr Gln Pro Pro Ser Ala Ser Ala Ser Leu Gly Ala 
1               5                   10                  15      


Ser Val Thr Leu Thr Cys Thr Leu Asn Ser Gly Tyr Ser Asp Tyr Lys 
            20                  25                  30          


Val Asp Trp Tyr Gln Gln Arg Pro Gly Lys Gly Pro Arg Phe Val Met 
        35                  40                  45              


Arg Val Gly Thr Gly Gly Ile Val Gly Ser Lys Gly Asp Gly Ile Pro 
    50                  55                  60                  


Asp Arg Phe Ser Val Leu Gly Ser Gly Leu Asn Arg Tyr Leu Thr Ile 
65                  70                  75                  80  


Lys Asn Ile Gln Glu Glu Asp Glu Ser Asp Tyr His Cys Gly Ala Asp 
                85                  90                  95      


His Gly Ser Gly Ser Asn Phe Val Tyr Val Phe Gly Thr Gly Thr Lys 
            100                 105                 110         


Val Thr Val Leu 
        115     


<210>  8
<211>  348
<212>  DNA
<213>  Homo sapiens

<400>  8
cagcctgtgc tgactcagcc accttctgca tcagcctccc tgggagcctc ggtcacactc       60

acctgcaccc tgaacagcgg ctacagtgat tataaagtgg actggtacca gcagagacca      120

gggaagggcc cccggtttgt gatgcgagtg ggcactggtg ggattgtggg atccaagggg      180

gatggcatcc ctgatcgctt ctcagtcttg ggctcaggcc tgaatcggta cctgaccatc      240

aagaatatcc aggaagagga tgagagtgac taccactgtg gggcagacca tggcagtggg      300

agcaacttcg tgtatgtctt cggaactggg accaaggtca ccgtccta                   348


<210>  9
<211>  116
<212>  PRT
<213>  Homo sapiens

<400>  9

Gln Pro Val Leu Thr Gln Pro Pro Ser Ala Ser Ala Ser Leu Gly Ala 
1               5                   10                  15      


Ser Val Thr Leu Thr Cys Thr Leu Ser Ser Gly Tyr Ser Asp Tyr Lys 
            20                  25                  30          


Val Asp Trp Tyr Gln Gln Arg Pro Gly Lys Gly Pro Arg Phe Val Met 
        35                  40                  45              


Arg Val Gly Thr Gly Gly Ile Val Gly Ser Lys Gly Glu Gly Ile Pro 
    50                  55                  60                  


Asp Arg Phe Ser Val Leu Gly Ser Gly Leu Asn Arg Tyr Leu Thr Ile 
65                  70                  75                  80  


Lys Asn Ile Gln Glu Glu Asp Glu Ser Asp Tyr His Cys Gly Ala Asp 
                85                  90                  95      


His Gly Ser Gly Asn Asn Phe Val Tyr Val Phe Gly Thr Gly Thr Lys 
            100                 105                 110         


Val Thr Val Leu 
        115     


<210>  10
<211>  348
<212>  DNA
<213>  Homo sapiens

<400>  10
cagcctgtgc tgactcagcc accttctgca tcagcctccc tgggagcctc ggtcacactc       60

acctgcaccc tgagcagcgg ctacagtgat tataaagtgg actggtacca gcagagacca      120

gggaagggcc cccggtttgt gatgcgagtg ggcactggtg ggattgtggg atccaagggg      180

gaaggcatcc ctgatcgctt ctcagtcttg ggctcaggcc tgaatcggta cctgaccatc      240

aagaacatcc aggaagagga tgagagtgac taccactgtg gggcagacca tggcagtggg      300

aacaacttcg tgtatgtctt cggaactggg accaaggtca ccgtccta                   348


<210>  11
<211>  116
<212>  PRT
<213>  Homo sapiens

<400>  11

Gln Pro Glu Leu Thr Gln Pro Pro Ser Ala Ser Ala Ser Leu Gly Ala 
1               5                   10                  15      


Ser Val Thr Leu Thr Cys Thr Leu Ser Ser Gly Tyr Ser Asp Tyr Lys 
            20                  25                  30          


Val Asp Trp Tyr Gln Leu Arg Pro Gly Lys Gly Pro Arg Phe Val Met 
        35                  40                  45              


Arg Val Gly Thr Gly Gly Thr Val Gly Ser Lys Gly Glu Gly Ile Pro 
    50                  55                  60                  


Asp Arg Phe Ser Val Leu Gly Ser Gly Leu Asn Arg Ser Leu Thr Ile 
65                  70                  75                  80  


Lys Asn Ile Gln Glu Glu Asp Glu Ser Asp Tyr His Cys Gly Ala Asp 
                85                  90                  95      


His Gly Ser Gly Ser Asn Phe Val Tyr Val Phe Gly Thr Gly Thr Lys 
            100                 105                 110         


Val Thr Val Leu 
        115     


<210>  12
<211>  348
<212>  DNA
<213>  Homo sapiens

<400>  12
cagcctgagt tgactcagcc accttctgca tcagcctccc tgggagcctc ggtcacactc       60

acctgcaccc tgagcagcgg ctacagtgat tataaagtgg actggtacca gctgagacca      120

gggaagggcc cccggtttgt gatgcgagtg ggcactggtg ggactgttgg atccaagggg      180

gaaggcatcc ctgatcgctt ctcagtcttg ggctcaggcc tgaatcggtc cctgaccatc      240

aagaacatcc aggaagagga tgagagtgac taccactgtg gggcagacca tggcagtggg      300

agcaacttcg tgtatgtctt cggaactggg accaaggtca ccgtccta                   348


<210>  13
<211>  107
<212>  PRT
<213>  Homo sapiens

<400>  13

Asp Ile Gln Leu Thr Pro Ser Pro Ser Ser Val Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Ala Gly Trp 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ala Asp Ser Phe Pro Pro 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210>  14
<211>  321
<212>  DNA
<213>  Homo sapiens

<400>  14
gacatccagt tgaccccgtc tccatcttcc gtgtctgcat ctgtaggaga cagagtcacc       60

atcacttgtc gggcgagtca gggtattgcc ggctggttag cctggtatca gcagaaacca      120

gggaaagccc ctaagctcct gatctatgct gcatccagtt tgcaaagtgg ggtcccatca      180

aggttcagcg gcagtggatc tgggacagat ttcactctca ccatcagcag cctgcagcct      240

gaagattttg caacttacta ttgtcaacag gctgacagtt tccctcccac tttcggcgga      300

gggaccaagg tggagatcaa a                                                321


<210>  15
<211>  107
<212>  PRT
<213>  Homo sapiens

<400>  15

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Val Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Val Ile Ser Ser Trp 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Ser Leu Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Val Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ala Asn Ser Phe Pro Phe 
                85                  90                  95      


Thr Phe Gly Pro Gly Thr Lys Val Asp Phe Lys 
            100                 105         


<210>  16
<211>  321
<212>  DNA
<213>  Homo sapiens

<400>  16
gacatccaga tgacccagtc tccatcttcc gtgtctgcat ctgtaggaga cagagtcacc       60

atcacttgtc gggcgagtca ggttattagc agctggttag cctggtatca gcagaaacca      120

gggaaagccc ctagcctcct gatctatgct gcatccagtt tgcaaagtgg ggtcccatca      180

aggttcagcg gcagtgtatc tgggacagat ttcactctca ccatcagcag cctgcagcct      240

gaagattttg caacttacta ttgtcaacag gctaacagtt tcccattcac tttcggccct      300

gggaccaaag tggatttcaa a                                                321


<210>  17
<211>  107
<212>  PRT
<213>  Homo sapiens

<400>  17

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Val Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ser Ser Ser Trp 
            20                  25                  30          


Phe Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ala Asn Ser Phe Pro Phe 
                85                  90                  95      


Thr Phe Gly Pro Gly Thr Lys Val Asp Ile Lys 
            100                 105         


<210>  18
<211>  321
<212>  DNA
<213>  Homo sapiens

<400>  18
gacatccaga tgacccagtc tccatcttcc gtgtctgcat ctgtaggaga cagagtcacc       60

atcacttgtc gggcgagtca gggaagtagc agctggtttg cctggtatca gcagaaacca      120

gggaaagccc caaagctcct gatctatgct gcatccagtt tgcaaagtgg ggtcccatca      180

aggttcagcg gcagtggatc tgggacagac ttcactctca ccatcagcag cctgcagcct      240

gaagattttg caacttacta ttgtcaacag gctaacagtt tcccattcac tttcggccct      300

gggaccaaag tggatatcaa a                                                321


<210>  19
<211>  107
<212>  PRT
<213>  Homo sapiens

<400>  19

Asp Ser Gln Met Thr Gln Ser Pro Ser Ser Val Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Ser Ser Trp 
            20                  25                  30          


Phe Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Asn Leu Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ala Asn Ser Phe Pro Phe 
                85                  90                  95      


Thr Phe Gly Pro Gly Thr Lys Val Asp Ile Lys 
            100                 105         


<210>  20
<211>  321
<212>  DNA
<213>  Homo sapiens

<400>  20
gacagccaga tgacccagtc tccatcttcc gtgtctgcct ctgtaggaga cagagtcacc       60

atcacttgtc gggcgagtca gggtattagc agctggtttg cctggtatca gcagaaacca      120

gggcaagccc ctaacctcct gatctatgct gcatccagtt tgcaaagtgg ggtcccatca      180

aggttcagcg gcagtggatc tgggacagaa ttcactctca ccatcagcag cctgcagcct      240

gaagattttg caacttacta ttgtcaacag gctaacagtt tcccattcac tttcggccct      300

gggaccaaag tggatatcaa a                                                321


<210>  21
<211>  107
<212>  PRT
<213>  Homo sapiens

<400>  21

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Val Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Gly Gln Val Ile Ser Ser Trp 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Asp Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ala Thr Ser Phe Pro Leu 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210>  22
<211>  321
<212>  DNA
<213>  Homo sapiens

<400>  22
gacatccaga tgacccagtc tccatcttcc gtgtctgcat ctgtaggaga cagagtcacc       60

atcacttgtc gggcgggtca ggttattagc agctggttag cctggtatca gcagaaacca      120

gggaaagccc ctaagctcct gatctatgct gcatccagtt tgcaaagtgg ggtcccatcg      180

aggttcagcg gcagtggatc tgggacagat ttcactctca ccatcagcag cctgcagcct      240

gacgattttg caacttacta ttgtcaacag gctaccagtt ttcccctcac tttcggcgga      300

gggaccaagg tggagatcaa a                                                321


<210>  23
<211>  107
<212>  PRT
<213>  Homo sapiens

<400>  23

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Val Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Phe Ser Gly Trp 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ala Asn Ser Phe Pro Phe 
                85                  90                  95      


Thr Phe Gly Pro Gly Thr Lys Val Asp Ile Lys 
            100                 105         


<210>  24
<211>  321
<212>  DNA
<213>  Homo sapiens

<400>  24
gacatccaga tgacccagtc tccatcttcc gtgtctgcat ctgtaggaga cagagtcacc       60

atcacttgtc gggcgagtca gggttttagc ggttggttag cctggtatca gcagaaacca      120

gggaaagccc ctaagctcct gatctatgct gcatccagtt tgcaaagtgg ggtcccatca      180

aggttcagtg gcagtggatc tgggacagat ttcactctca ccatcagcag cctgcagcct      240

gaagattttg caacttacta ctgtcaacag gctaacagtt tcccattcac tttcggccct      300

gggaccaaag tggatatcaa a                                                321


<210>  25
<211>  107
<212>  PRT
<213>  Homo sapiens

<400>  25

Asp Ile Gln Leu Thr Gln Ser Pro Ser Ser Val Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Val Ile Ser Ser Trp 
            20                  25                  30          


Phe Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Asn Leu Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Ala Asp Phe Ala Thr Tyr Phe Cys Gln Gln Ala Asn Ser Phe Pro Phe 
                85                  90                  95      


Thr Phe Gly Pro Gly Thr Lys Val Asp Val Lys 
            100                 105         


<210>  26
<211>  321
<212>  DNA
<213>  Homo sapiens

<400>  26
gacatccagt tgacccagtc tccatcttcc gtgtctgcat ctgtaggaga cagagtcacc       60

atcacttgtc gggcgagtca ggttattagc agctggtttg cctggtatca gcagaaacca      120

gggaaagccc ctaacctcct gatctatgct gcatccagtt tgcaaagtgg ggtcccatca      180

aggttcagcg gcagtggatc tgggacagat ttcactctca ccatcagcag cctgcagcct      240

gcagattttg caacttactt ttgtcaacag gctaacagtt tcccattcac tttcggccct      300

gggaccaaag tggatgtcaa a                                                321


<210>  27
<211>  107
<212>  PRT
<213>  Homo sapiens

<400>  27

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Val Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ser Ser Ser Trp 
            20                  25                  30          


Phe Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ala Asn Ser Phe Pro Phe 
                85                  90                  95      


Thr Phe Gly Pro Gly Thr Lys Val Asp Ile Lys 
            100                 105         


<210>  28
<211>  321
<212>  DNA
<213>  Homo sapiens

<400>  28
gacatccaga tgacccagtc tccatcttcc gtgtctgcat ctgtaggaga cagagtcacc       60

atcacttgtc gggcgagtca gggtagtagc agctggtttg cctggtatca acagaaacca      120

gggaaagccc caaagctcct gatctatgct gcatccagtt tgcaaagtgg ggtcccatca      180

aggttcagcg gcagtggatc tgggacagat ttcactctca ccatcagcag cctgcagcct      240

gaagattttg caacttacta ttgtcaacag gctaacagtt tcccattcac tttcggccct      300

gggaccaaag tggatatcaa a                                                321


<210>  29
<211>  107
<212>  PRT
<213>  Homo sapiens

<400>  29

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Arg Asn Asp 
            20                  25                  30          


Leu Gly Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Arg Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Leu Gln His Asn Ser Tyr Pro Pro 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Glu 
            100                 105         


<210>  30
<211>  108
<212>  PRT
<213>  Artificial

<220>
<223>  Consensus Sequence


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa can be Ile or Ser

<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  Xaa can be Met or Leu

<220>
<221>  MISC_FEATURE
<222>  (29)..(29)
<223>  Xaa can be Gly or Val

<220>
<221>  MISC_FEATURE
<222>  (30)..(30)
<223>  Xaa can be Ser, Phe or Ile

<220>
<221>  MISC_FEATURE
<222>  (32)..(32)
<223>  Xaa can be Ser or Gly

<220>
<221>  MISC_FEATURE
<222>  (34)..(34)
<223>  Xaa can be Phe or Leu

<220>
<221>  MISC_FEATURE
<222>  (43)..(43)
<223>  Xaa can be Lys or Gln

<220>
<221>  MISC_FEATURE
<222>  (46)..(46)
<223>  Xaa can be Lys, Asn or Ser

<220>
<221>  MISC_FEATURE
<222>  (67)..(67)
<223>  Xaa can be Gly or Val

<220>
<221>  MISC_FEATURE
<222>  (71)..(71)
<223>  Xaa can be Asp or Glu

<220>
<221>  MISC_FEATURE
<222>  (82)..(82)
<223>  Xaa can be Glu or Ala

<220>
<221>  MISC_FEATURE
<222>  (88)..(88)
<223>  Xaa can be Try or Phe

<220>
<221>  MISC_FEATURE
<222>  (107)..(107)
<223>  Xaa can be Ile, Val or Phe

<400>  30

Asp Xaa Gln Xaa Thr Gln Ser Pro Ser Ser Val Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Xaa Xaa Ser Xaa 
            20                  25                  30          


Trp Xaa Ala Trp Tyr Gln Gln Lys Pro Gly Xaa Ala Pro Xaa Leu Leu 
        35                  40                  45              


Ile Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser 
    50                  55                  60                  


Gly Ser Xaa Ser Gly Thr Xaa Phe Thr Leu Thr Ile Ser Ser Leu Gln 
65                  70                  75                  80  


Pro Xaa Asp Phe Ala Thr Tyr Xaa Cys Gln Gln Ala Asn Ser Phe Pro 
                85                  90                  95      


Phe Thr Phe Gly Pro Gly Thr Lys Val Asp Xaa Lys 
            100                 105             


<210>  31
<211>  124
<212>  PRT
<213>  Homo sapiens

<400>  31

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Val Ile Trp Tyr Asp Gly Ser Asn Glu Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Arg Gly Tyr Thr Ser Ser Trp Tyr Pro Asp Ala Phe Asp 
            100                 105                 110         


Ile Trp Gly Gln Gly Thr Met Val Thr Val Ser Ser 
        115                 120                 


<210>  32
<211>  372
<212>  DNA
<213>  Homo sapiens

<400>  32
caggtgcagc tggtggagtc tgggggaggc gtggtccagc ctgggaggtc cctgagactc       60

tcctgtgcag cgtctggatt caccttcagt agctatggca tgcactgggt ccgccaggct      120

ccaggcaagg ggctggagtg ggtggcagtt atatggtatg atggaagtaa tgaatactat      180

gcagactccg tgaagggccg attcaccatc tccagagaca attccaagaa cacgctgtat      240

ctgcaaatga acagcctgag agccgaggac acggctgtgt attactgtgc gagagatcgg      300

gggtatacca gtagctggta ccctgatgct tttgatatct ggggccaagg gacaatggtc      360

accgtctctt ca                                                          372


<210>  33
<211>  124
<212>  PRT
<213>  Homo sapiens

<400>  33

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Val Ile Trp Tyr Asp Gly Ser Asn Lys Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Arg Gly Tyr Ser Ser Ser Trp Tyr Pro Asp Ala Phe Asp 
            100                 105                 110         


Ile Trp Gly Gln Gly Thr Met Val Thr Val Ser Ser 
        115                 120                 


<210>  34
<211>  121
<212>  PRT
<213>  Homo sapiens

<400>  34

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Val Ile Ser Phe Asp Gly Ser Leu Lys Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Glu Arg Thr Thr Leu Ser Gly Ser Tyr Phe Asp Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120     


<210>  35
<211>  363
<212>  DNA
<213>  Homo sapiens

<400>  35
caggtgcagc tggtggagtc tgggggaggc gtggtccagc ctgggaggtc cctgagactc       60

tcctgtgcag cctctggatt caccttcagt agctatggca tgcactgggt ccgccaggct      120

ccaggcaagg ggctggagtg ggtggcagtt atatcatttg atggaagtct taaatactat      180

gcagactccg tgaagggccg attcaccatc tccagagaca attccaagaa caccctgtat      240

ctgcaaatga acagcctgag agctgaggac acggctgtgt attactgtgc gagagaacgg      300

actactttaa gtgggagcta ctttgactac tggggccagg gaaccctggt caccgtctcc      360

tca                                                                    363


<210>  36
<211>  121
<212>  PRT
<213>  Homo sapiens

<400>  36

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Leu 
        35                  40                  45              


Ser Val Ile Ser His Asp Gly Ser Ile Lys Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Glu Arg Thr Thr Leu Ser Gly Ser Tyr Phe Asp Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120     


<210>  37
<211>  363
<212>  DNA
<213>  Homo sapiens

<400>  37
caggtgcagc tggtggagtc tgggggaggc gtggtccagc ctgggaggtc cctgagactc       60

tcctgtgcag cctctggatt caccttcagt agctatgcca tgcactgggt ccgccaggct      120

ccaggcaagg ggctggagtg gttgtcagtt atatcacatg atggaagtat taaatactat      180

gcagactccg tgaagggccg attcaccatc tccagagaca attccaagaa cacgctgtat      240

ctgcaaatga acagcctgag agctgaggac acggctgtgt attactgtgc gagagaacgg      300

actactctaa gtgggagcta ctttgactac tggggccagg gaaccctggt caccgtctcc      360

tca                                                                    363


<210>  38
<211>  125
<212>  PRT
<213>  Homo sapiens

<400>  38

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ser Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Tyr Ile Ser Ser Arg Ser Ser Thr Ile Tyr Ile Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Asp Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Arg Ile Ala Ala Ala Gly Gly Phe His Tyr Tyr Tyr Ala Leu 
            100                 105                 110         


Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 
        115                 120                 125 


<210>  39
<211>  375
<212>  DNA
<213>  Homo sapiens

<400>  39
gaggtgcagc tggtggagtc tgggggaggc ctggtacagc ctggggggtc cctgagactc       60

tcctgtgcag cctctggatt caccttcagt agctatagta tgaactgggt ccgccaggct      120

ccagggaagg ggctggagtg ggtttcgtac attagtagta ggagtagtac catatacatc      180

gcagactctg tgaagggccg attcaccatc tccagagaca atgccaagaa ctcactgtat      240

ctgcaaatga acagcctgag agacgaagac acggctgtgt attactgtgc gagacggata      300

gcagcagctg gtgggttcca ctactactac gctttggacg tctggggcca agggaccacg      360

gtcaccgtct cctca                                                       375


<210>  40
<211>  125
<212>  PRT
<213>  Homo sapiens

<400>  40

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Thr Tyr 
            20                  25                  30          


Ser Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Tyr Ile Ser Ser Ser Ser Ser Thr Arg Tyr His Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Asp Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Arg Ile Ala Ala Ala Gly Pro Trp Gly Tyr Tyr Tyr Ala Met 
            100                 105                 110         


Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 
        115                 120                 125 


<210>  41
<211>  375
<212>  DNA
<213>  Homo sapiens

<400>  41
gaggtgcagc tggtggagtc tgggggaggc ttggtacaac ctggggggtc cctgagactc       60

tcctgtgcag cctctggatt caccttcagt acctatagca tgaactgggt ccgccaggct      120

ccagggaagg ggctggagtg ggtttcatac attagtagca gtagtagtac cagataccac      180

gcagactctg tgaagggccg attcaccatc tccagagaca atgccaagaa ctcactgtat      240

ctgcaaatga acagcctgag agacgaggac acggctgtgt attactgtgc gagacgtata      300

gcagcagctg gtccgtgggg ctactactac gctatggacg tctggggcca agggaccacg      360

gtcaccgtct cctca                                                       375


<210>  42
<211>  125
<212>  PRT
<213>  Homo sapiens

<400>  42

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Val Val Ser Gly Phe Thr Phe Ser Ser Phe 
            20                  25                  30          


Ser Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Tyr Ile Ser Ser Arg Ser Ser Thr Ile Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Asp Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Arg Ile Ala Ala Ala Gly Pro Trp Gly Tyr Tyr Tyr Ala Met 
            100                 105                 110         


Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 
        115                 120                 125 


<210>  43
<211>  375
<212>  DNA
<213>  Homo sapiens

<400>  43
gaggtgcagc tggtggagtc tgggggaggc ttggtacagc ctggggggtc cctgagactc       60

tcctgtgtag tctctggatt caccttcagt agttttagca tgaactgggt ccgccaggct      120

ccagggaagg ggctggagtg ggtttcatac attagtagtc gtagtagtac catatactac      180

gcagactctg tgaagggccg attcaccatc tccagagaca atgccaagaa ctcactgtat      240

ctgcaaatga acagcctgag agacgaggac acggctgtgt attattgtgc gagacgtata      300

gcagcagctg gtccgtgggg ctactactac gctatggacg tctggggcca agggaccacg      360

gtcaccgtct cctca                                                       375


<210>  44
<211>  118
<212>  PRT
<213>  Homo sapiens

<400>  44

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Gly Ser Ile Ser Thr Tyr 
            20                  25                  30          


Tyr Trp Ser Trp Ile Arg Gln Pro Ala Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Leu Ile Tyr Thr Ser Gly Ser Thr Asn Tyr Asn Pro Ser Leu Lys 
    50                  55                  60                  


Ser Arg Val Thr Met Ser Leu Asp Thr Ser Lys Asn Gln Phe Ser Leu 
65                  70                  75                  80  


Arg Leu Thr Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Asp Arg Gly Tyr Tyr Tyr Gly Val Asp Val Trp Gly Gln Gly Thr 
            100                 105                 110         


Thr Val Thr Val Ser Ser 
        115             


<210>  45
<211>  354
<212>  DNA
<213>  Homo sapiens

<400>  45
caggtgcagc tgcaggagtc gggcccagga ctggtgaagc cttcggagac cctgtccctc       60

acctgcactg tctctggtgg ctccatcagt acttactact ggagctggat ccggcagccc      120

gccgggaagg gactggagtg gattgggctt atctatacca gtgggagcac caactacaac      180

ccctccctca agagtcgagt caccatgtca ttagacacgt ccaagaacca gttctccctg      240

aggctgacct ctgtgaccgc cgcggacacg gccgtttatt actgtgcgag agatcgtggg      300

tactactacg gtgtggacgt ctggggccag gggaccacgg tcaccgtctc ctca            354


<210>  46
<211>  120
<212>  PRT
<213>  Homo sapiens

<400>  46

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gln 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Gly Ser Ile Ser Ser Gly 
            20                  25                  30          


Gly Tyr Tyr Trp Ser Trp Ile Arg Gln His Pro Gly Lys Gly Leu Glu 
        35                  40                  45              


Trp Ile Gly His Ile His Tyr Ser Gly Asn Thr Tyr Tyr Asn Pro Ser 
    50                  55                  60                  


Leu Lys Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe 
65                  70                  75                  80  


Ser Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr 
                85                  90                  95      


Cys Ala Lys Asn Arg Gly Phe Tyr Tyr Gly Met Asp Val Trp Gly Gln 
            100                 105                 110         


Gly Thr Thr Val Thr Val Ser Ser 
        115                 120 


<210>  47
<211>  360
<212>  DNA
<213>  Homo sapiens

<400>  47
caggtgcagc tgcaggagtc gggcccagga ctggtgaagc cttcacagac cctgtccctc       60

acctgcactg tctctggtgg ctccatcagc agtggtggtt actactggag ctggatccgc      120

cagcacccag ggaagggcct ggagtggatt gggcacatcc attacagtgg gaacacctac      180

tacaacccgt ccctcaagag tcgagttacc atatcagtag acacgtctaa gaatcagttc      240

tccctgaaac tgagctctgt gactgccgcg gacacggccg tgtattactg tgcgaaaaat      300

cgcgggttct actacggtat ggacgtctgg ggccaaggga ccacggtcac cgtctcctca      360


<210>  48
<211>  120
<212>  PRT
<213>  Homo sapiens

<400>  48

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gln 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Gly Ser Ile Asn Ser Gly 
            20                  25                  30          


Gly Tyr Tyr Trp Ser Trp Ile Arg Gln His Pro Gly Lys Gly Leu Glu 
        35                  40                  45              


Trp Ile Gly Tyr Ile Tyr Tyr Ser Gly Ser Ser Tyr Tyr Asn Pro Ser 
    50                  55                  60                  


Leu Lys Ser Arg Val Thr Ile Ser Val Asp Thr Ser Gln Asn Gln Phe 
65                  70                  75                  80  


Ser Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr 
                85                  90                  95      


Cys Ala Arg Asp Arg Gly His Tyr Tyr Gly Met Asp Val Trp Gly Gln 
            100                 105                 110         


Gly Thr Thr Val Thr Val Ser Ser 
        115                 120 


<210>  49
<211>  360
<212>  DNA
<213>  Homo sapiens

<400>  49
caggtgcagc tgcaggagtc gggcccagga ctggtgaagc cttcacagac cctgtccctc       60

acctgcactg tctctggtgg ctccatcaac agtggtggtt actactggag ctggatccgc      120

cagcacccag ggaagggcct ggagtggatt gggtacatct attacagtgg gagctcctac      180

tacaacccgt ccctcaagag tcgagttacc atatcagtag acacgtctca gaaccagttc      240

tccctgaagc tgagctctgt gactgccgcg gacacggccg tgtattactg tgcgagagat      300

cgggggcact actacggtat ggacgtctgg ggccaaggga ccacggtcac cgtctcctca      360


<210>  50
<211>  120
<212>  PRT
<213>  Homo sapiens

<400>  50

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gln 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Gly Ser Ile Ser Ser Gly 
            20                  25                  30          


Gly Tyr Tyr Trp Ser Trp Ile Arg Gln His Pro Gly Lys Gly Leu Glu 
        35                  40                  45              


Trp Ile Gly Tyr Ile Tyr Tyr Ser Gly Ser Thr Tyr Tyr Asn Pro Ser 
    50                  55                  60                  


Leu Lys Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe 
65                  70                  75                  80  


Ser Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr 
                85                  90                  95      


Cys Ala Arg Asp Arg Gly His Tyr Tyr Gly Met Asp Val Trp Gly Gln 
            100                 105                 110         


Gly Thr Thr Val Thr Val Ser Ser 
        115                 120 


<210>  51
<211>  360
<212>  DNA
<213>  Homo sapiens

<400>  51
caggtgcagc tgcaggagtc gggcccagga ctggtgaagc cttcacagac cctgtccctc       60

acctgcactg tctctggtgg ctccatcagt agtggtggtt actactggag ctggatccgc      120

cagcacccag ggaagggcct ggagtggatt gggtacattt attacagtgg gagcacctac      180

tacaacccgt ccctcaagag tcgagttacc atatcagtag acacgtctaa gaaccagttc      240

tccctgaagc tgagctctgt gactgccgcg gacacggccg tgtattactg tgcgagagat      300

cggggccact actatggaat ggacgtctgg ggccaaggga ccacggtcac cgtctcctca      360


<210>  52
<211>  118
<212>  PRT
<213>  Homo sapiens

<400>  52

Gln Val Gln Leu Gln Glu Ser Gly Pro Arg Leu Val Lys Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Asp Ser Ile Ser Ser Tyr 
            20                  25                  30          


Phe Trp Ser Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Leu 
        35                  40                  45              


Gly Tyr Ile Tyr Tyr Ser Gly Ser Thr Asn Tyr Asn Pro Ser Leu Lys 
    50                  55                  60                  


Ser Arg Val Thr Ile Ser Ile Asp Thr Ser Lys Asn Gln Phe Ser Leu 
65                  70                  75                  80  


Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Thr 
                85                  90                  95      


Arg Asp Arg Gly Ser Tyr Tyr Gly Ser Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser 
        115             


<210>  53
<211>  354
<212>  DNA
<213>  Homo sapiens

<400>  53
caggtgcagc tgcaggagtc gggcccaaga ctggtgaagc cttcggagac cctgtccctc       60

acctgcactg tctctggtga ctccatcagt agttacttct ggagctggat ccggcagccc      120

ccagggaagg gactggagtg gcttgggtat atctattaca gtgggagcac caactacaac      180

ccctccctca agagtcgagt caccatatca atagacacgt ccaagaacca gttctccctg      240

aagctgagct ctgtgaccgc tgcggacacg gccgtgtatt actgtacgag agatcggggg      300

agctactacg gatctgacta ctggggccag ggaaccctgg tcaccgtctc ctca            354


<210>  54
<211>  120
<212>  PRT
<213>  Homo sapiens

<400>  54

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gln 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Gly Ser Ile Ser Ser Gly 
            20                  25                  30          


Gly Tyr Tyr Trp Thr Trp Ile Arg Gln His Pro Gly Lys Gly Leu Glu 
        35                  40                  45              


Trp Ile Gly Tyr Ile Tyr Tyr Ser Gly Asn Thr Tyr Tyr Asn Pro Ser 
    50                  55                  60                  


Leu Lys Ser Arg Ile Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe 
65                  70                  75                  80  


Ser Leu Ser Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr 
                85                  90                  95      


Cys Ala Arg Asn Arg Gly Tyr Tyr Tyr Gly Met Asp Val Trp Gly Gln 
            100                 105                 110         


Gly Thr Thr Val Thr Val Ser Ser 
        115                 120 


<210>  55
<211>  360
<212>  DNA
<213>  Homo sapiens

<400>  55
caggtgcagc tgcaggagtc gggcccagga ctggtgaagc cttcacagac cctgtccctc       60

acctgcactg tctctggtgg ctccatcagc agtggtggtt actactggac ctggatccgc      120

cagcacccag ggaagggcct ggagtggatt gggtacatct attacagtgg gaacacctac      180

tacaacccgt ccctcaagag tcgaattacc atatcagtgg acacgtctaa gaaccagttc      240

tccctgagcc tgagctctgt gactgccgcg gacacggccg tgtattactg tgcgagaaat      300

cgcgggtact actacggtat ggacgtctgg ggccaaggga ccacggtcac cgtctcctca      360


<210>  56
<211>  120
<212>  PRT
<213>  Homo sapiens

<400>  56

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gln 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Gly Ser Ile Ser Ser Gly 
            20                  25                  30          


Gly Tyr Tyr Trp Ser Trp Ile Arg Gln His Pro Gly Lys Gly Leu Glu 
        35                  40                  45              


Trp Ile Gly Tyr Ile Tyr Tyr Ser Gly Ser Thr Tyr Tyr Asn Pro Ser 
    50                  55                  60                  


Leu Lys Ser Arg Val Thr Met Ser Val Asp Thr Ser Lys Asn Gln Phe 
65                  70                  75                  80  


Ser Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr 
                85                  90                  95      


Cys Ala Lys Asn Arg Gly Phe Tyr Tyr Gly Met Asp Val Trp Gly Gln 
            100                 105                 110         


Gly Thr Thr Val Thr Val Ser Ser 
        115                 120 


<210>  57
<211>  360
<212>  DNA
<213>  Homo sapiens

<400>  57
caggtgcagc tgcaggagtc gggcccagga ctggtgaagc cttcacagac cctgtccctc       60

acctgcactg tctctggtgg ctccatcagc agtggtggtt actactggag ctggatccgc      120

cagcacccag ggaagggcct ggagtggatt gggtacatct attacagtgg gagcacctac      180

tacaacccgt ccctcaagag tcgagttacc atgtcagtag acacgtctaa gaaccagttc      240

tccctgaaac tgagctctgt gactgccgcg gacacggccg tgtattactg tgcgaaaaat      300

cgcgggttct actacggtat ggacgtctgg ggccaaggga ccacggtcac cgtctcctca      360


<210>  58
<211>  120
<212>  PRT
<213>  Homo sapiens

<400>  58

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gln 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Gly Ser Ile Asn Ser Gly 
            20                  25                  30          


Gly Tyr Tyr Trp Ser Trp Ile Arg Gln His Pro Gly Lys Gly Leu Glu 
        35                  40                  45              


Trp Ile Gly Tyr Ile Tyr Tyr Ser Gly Ser Ser Tyr Tyr Asn Pro Ser 
    50                  55                  60                  


Leu Lys Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe 
65                  70                  75                  80  


Ser Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr 
                85                  90                  95      


Cys Ala Arg Asp Arg Gly His Tyr Tyr Gly Met Asp Val Trp Gly Gln 
            100                 105                 110         


Gly Thr Thr Val Thr Val Ser Ser 
        115                 120 


<210>  59
<211>  360
<212>  DNA
<213>  Homo sapiens

<400>  59
caggtgcagc tgcaggagtc gggcccagga ctggtgaagc cttcacagac cctgtccctc       60

acctgcactg tctctggtgg ctccatcaat agtggtggtt actactggag ctggatccgc      120

cagcacccag ggaagggcct ggagtggatt gggtacatct attacagtgg gagcagctac      180

tacaacccgt ccctcaagag tcgagttacc atatcagttg acacgtctaa gaaccagttc      240

tccctgaagc tgagttctgt gactgccgcg gacacggccg tgtattactg tgcgagagat      300

cgggggcact actacggtat ggacgtctgg ggccaaggga ccacggtcac cgtctcctca      360


<210>  60
<211>  123
<212>  PRT
<213>  Homo sapiens

<400>  60

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Leu Ile Trp Tyr Asp Gly Ser Asn Lys Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Glu Asn Thr Val Thr Ile Tyr Tyr Asn Tyr Gly Met Asp Val 
            100                 105                 110         


Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 
        115                 120             


<210>  61
<211>  116
<212>  PRT
<213>  Artificial

<220>
<223>  Consensus Sequence


<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  Xaa can be Val or Glu

<220>
<221>  MISC_FEATURE
<222>  (25)..(25)
<223>  Xaa can be Asn or Ser

<220>
<221>  MISC_FEATURE
<222>  (38)..(38)
<223>  Xaa can be Gln or Leu

<220>
<221>  MISC_FEATURE
<222>  (55)..(55)
<223>  Xaa can be Ile or Thr

<220>
<221>  MISC_FEATURE
<222>  (61)..(61)
<223>  Xaa can be Asp or Glu

<220>
<221>  MISC_FEATURE
<222>  (77)..(77)
<223>  Xaa can be Tyr or Ser

<220>
<221>  MISC_FEATURE
<222>  (101)..(101)
<223>  Xaa can be Ser or Asn

<400>  61

Gln Pro Xaa Leu Thr Gln Pro Pro Ser Ala Ser Ala Ser Leu Gly Ala 
1               5                   10                  15      


Ser Val Thr Leu Thr Cys Thr Leu Xaa Ser Gly Tyr Ser Asp Tyr Lys 
            20                  25                  30          


Val Asp Trp Tyr Gln Xaa Arg Pro Gly Lys Gly Pro Arg Phe Val Met 
        35                  40                  45              


Arg Val Gly Thr Gly Gly Xaa Val Gly Ser Lys Gly Xaa Gly Ile Pro 
    50                  55                  60                  


Asp Arg Phe Ser Val Leu Gly Ser Gly Leu Asn Arg Xaa Leu Thr Ile 
65                  70                  75                  80  


Lys Asn Ile Gln Glu Glu Asp Glu Ser Asp Tyr His Cys Gly Ala Asp 
                85                  90                  95      


His Gly Ser Gly Xaa Asn Phe Val Tyr Val Phe Gly Thr Gly Thr Lys 
            100                 105                 110         


Val Thr Val Leu 
        115     


<210>  62
<211>  14
<212>  PRT
<213>  Homo sapiens

<400>  62

Thr Gly Ser Ser Ser Asn Thr Gly Ala Gly Tyr Asp Val His 
1               5                   10                  


<210>  63
<211>  7
<212>  PRT
<213>  Homo sapiens

<400>  63

Gly Ser Gly Asn Arg Pro Ser 
1               5           


<210>  64
<211>  11
<212>  PRT
<213>  Homo sapiens

<400>  64

Gln Ser Tyr Asp Ser Ser Leu Ser Gly Trp Val 
1               5                   10      


<210>  65
<211>  14
<212>  PRT
<213>  Homo sapiens

<400>  65

Thr Gly Ser Ser Ser Asn Ile Gly Ala Gly Tyr Asp Val His 
1               5                   10                  


<210>  66
<211>  7
<212>  PRT
<213>  Homo sapiens

<400>  66

Gly Ser Asn Asn Arg Pro Ser 
1               5           


<210>  67
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  67

Met Ile Trp His Ser Ser Ala Ser Val 
1               5                   


<210>  68
<211>  14
<212>  PRT
<213>  Homo sapiens

<400>  68

Thr Leu Arg Ser Gly Ile Asn Val Gly Thr Tyr Arg Ile Tyr 
1               5                   10                  


<210>  69
<211>  11
<212>  PRT
<213>  Homo sapiens

<400>  69

Tyr Lys Ser Asp Ser Asp Lys Gln Gln Gly Ser 
1               5                   10      


<210>  70
<211>  13
<212>  PRT
<213>  Homo sapiens

<400>  70

Gly Ala Asp His Gly Ser Gly Ser Asn Phe Val Tyr Val 
1               5                   10              


<210>  71
<211>  11
<212>  PRT
<213>  Homo sapiens

<400>  71

Thr Leu Asn Ser Gly Tyr Ser Asp Tyr Lys Val 
1               5                   10      


<210>  72
<211>  12
<212>  PRT
<213>  Homo sapiens

<400>  72

Val Gly Thr Gly Gly Ile Val Gly Ser Lys Gly Asp 
1               5                   10          


<210>  73
<211>  13
<212>  PRT
<213>  Homo sapiens

<400>  73

Gly Ala Asp His Gly Ser Gly Asn Asn Phe Val Tyr Val 
1               5                   10              


<210>  74
<211>  11
<212>  PRT
<213>  Homo sapiens

<400>  74

Thr Leu Ser Ser Gly Tyr Ser Asp Tyr Lys Val 
1               5                   10      


<210>  75
<211>  12
<212>  PRT
<213>  Homo sapiens

<400>  75

Val Gly Thr Gly Gly Ile Val Gly Ser Lys Gly Glu 
1               5                   10          


<210>  76
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  76

Gln Gln Ala Asn Ser Phe Pro Phe Thr 
1               5                   


<210>  77
<211>  11
<212>  PRT
<213>  Homo sapiens

<400>  77

Arg Ala Ser Gln Gly Phe Ser Gly Trp Leu Ala 
1               5                   10      


<210>  78
<211>  12
<212>  PRT
<213>  Homo sapiens

<400>  78

Val Gly Thr Gly Gly Thr Val Gly Ser Lys Gly Glu 
1               5                   10          


<210>  79
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  79

Gln Gln Ala Thr Ser Phe Pro Leu Thr 
1               5                   


<210>  80
<211>  11
<212>  PRT
<213>  Homo sapiens

<400>  80

Arg Ala Ser Gln Val Ile Ser Ser Trp Leu Ala 
1               5                   10      


<210>  81
<211>  7
<212>  PRT
<213>  Homo sapiens

<400>  81

Ala Ala Ser Ser Leu Gln Ser 
1               5           


<210>  82
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  82

Gln Gln Ala Asp Ser Phe Pro Pro Thr 
1               5                   


<210>  83
<211>  11
<212>  PRT
<213>  Homo sapiens

<400>  83

Arg Ala Ser Gln Val Ile Ser Ser Trp Phe Ala 
1               5                   10      


<210>  84
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  84

Leu Gln His Asn Ser Tyr Pro Pro Thr 
1               5                   


<210>  85
<211>  11
<212>  PRT
<213>  Homo sapiens

<400>  85

Arg Ala Ser Gln Gly Ser Ser Ser Trp Phe Ala 
1               5                   10      


<210>  86
<211>  11
<212>  PRT
<213>  Homo sapiens

<400>  86

Arg Ala Ser Gln Gly Ile Ser Ser Trp Phe Ala 
1               5                   10      


<210>  87
<211>  11
<212>  PRT
<213>  Homo sapiens

<400>  87

Arg Ala Gly Gln Val Ile Ser Ser Trp Leu Ala 
1               5                   10      


<210>  88
<211>  11
<212>  PRT
<213>  Homo sapiens

<400>  88

Arg Ala Ser Gln Gly Ile Ala Gly Trp Leu Ala 
1               5                   10      


<210>  89
<211>  11
<212>  PRT
<213>  Homo sapiens

<400>  89

Arg Ala Ser Gln Gly Ile Arg Asn Asp Leu Gly 
1               5                   10      


<210>  90
<211>  17
<212>  PRT
<213>  Homo sapiens

<400>  90

Leu Ile Trp Tyr Asp Gly Ser Asn Lys Tyr Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  91
<211>  5
<212>  PRT
<213>  Homo sapiens

<400>  91

Ser Tyr Gly Met His 
1               5   


<210>  92
<211>  17
<212>  PRT
<213>  Homo sapiens

<400>  92

Val Ile Trp Tyr Asp Gly Ser Asn Glu Tyr Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  93
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  93

Asp Arg Gly Tyr Thr Ser Ser Trp Tyr Pro Asp Ala Phe Asp Ile 
1               5                   10                  15  


<210>  94
<211>  5
<212>  PRT
<213>  Homo sapiens

<400>  94

Ser Tyr Ala Met His 
1               5   


<210>  95
<211>  17
<212>  PRT
<213>  Homo sapiens

<400>  95

Val Ile Trp Tyr Asp Gly Ser Asn Lys Tyr Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  96
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  96

Asp Arg Gly Tyr Ser Ser Ser Trp Tyr Pro Asp Ala Phe Asp Ile 
1               5                   10                  15  


<210>  97
<211>  5
<212>  PRT
<213>  Homo sapiens

<400>  97

Thr Tyr Ser Met Asn 
1               5   


<210>  98
<211>  17
<212>  PRT
<213>  Homo sapiens

<400>  98

Val Ile Ser Phe Asp Gly Ser Leu Lys Tyr Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  99
<211>  12
<212>  PRT
<213>  Homo sapiens

<400>  99

Glu Arg Thr Thr Leu Ser Gly Ser Tyr Phe Asp Tyr 
1               5                   10          


<210>  100
<211>  5
<212>  PRT
<213>  Homo sapiens

<400>  100

Ser Tyr Ser Met Asn 
1               5   


<210>  101
<211>  17
<212>  PRT
<213>  Homo sapiens

<400>  101

Val Ile Ser His Asp Gly Ser Ile Lys Tyr Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  102
<211>  16
<212>  PRT
<213>  Homo sapiens

<400>  102

Arg Ile Ala Ala Ala Gly Gly Phe His Tyr Tyr Tyr Ala Leu Asp Val 
1               5                   10                  15      


<210>  103
<211>  5
<212>  PRT
<213>  Homo sapiens

<400>  103

Ser Phe Ser Met Asn 
1               5   


<210>  104
<211>  17
<212>  PRT
<213>  Homo sapiens

<400>  104

Tyr Ile Ser Ser Arg Ser Ser Thr Ile Tyr Ile Ala Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  105
<211>  16
<212>  PRT
<213>  Homo sapiens

<400>  105

Arg Ile Ala Ala Ala Gly Pro Trp Gly Tyr Tyr Tyr Ala Met Asp Val 
1               5                   10                  15      


<210>  106
<211>  7
<212>  PRT
<213>  Homo sapiens

<400>  106

Ser Gly Gly Tyr Tyr Trp Thr 
1               5           


<210>  107
<211>  17
<212>  PRT
<213>  Homo sapiens

<400>  107

Tyr Ile Ser Ser Ser Ser Ser Thr Arg Tyr His Ala Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  108
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  108

Asn Arg Gly Tyr Tyr Tyr Gly Met Asp Val 
1               5                   10  


<210>  109
<211>  7
<212>  PRT
<213>  Homo sapiens

<400>  109

Ser Gly Gly Tyr Tyr Trp Ser 
1               5           


<210>  110
<211>  17
<212>  PRT
<213>  Homo sapiens

<400>  110

Tyr Ile Ser Ser Arg Ser Ser Thr Ile Tyr Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  111
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  111

Asn Arg Gly Phe Tyr Tyr Gly Met Asp Val 
1               5                   10  


<210>  112
<211>  5
<212>  PRT
<213>  Homo sapiens

<400>  112

Ser Tyr Phe Trp Ser 
1               5   


<210>  113
<211>  16
<212>  PRT
<213>  Homo sapiens

<400>  113

Tyr Ile Tyr Tyr Ser Gly Asn Thr Tyr Tyr Asn Pro Ser Leu Lys Ser 
1               5                   10                  15      


<210>  114
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  114

Asp Arg Gly His Tyr Tyr Gly Met Asp Val 
1               5                   10  


<210>  115
<211>  5
<212>  PRT
<213>  Homo sapiens

<400>  115

Thr Tyr Tyr Trp Ser 
1               5   


<210>  116
<211>  16
<212>  PRT
<213>  Homo sapiens

<400>  116

His Ile His Tyr Ser Gly Asn Thr Tyr Tyr Asn Pro Ser Leu Lys Ser 
1               5                   10                  15      


<210>  117
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  117

Asp Arg Gly Ser Tyr Tyr Gly Ser Asp Tyr 
1               5                   10  


<210>  118
<211>  16
<212>  PRT
<213>  Homo sapiens

<400>  118

Tyr Ile Tyr Tyr Ser Gly Ser Thr Tyr Tyr Asn Pro Ser Leu Lys Ser 
1               5                   10                  15      


<210>  119
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  119

Asp Arg Gly Tyr Tyr Tyr Gly Val Asp Val 
1               5                   10  


<210>  120
<211>  16
<212>  PRT
<213>  Homo sapiens

<400>  120

Tyr Ile Tyr Tyr Ser Gly Ser Ser Tyr Tyr Asn Pro Ser Leu Lys Ser 
1               5                   10                  15      


<210>  121
<211>  16
<212>  PRT
<213>  Homo sapiens

<400>  121

Tyr Ile Tyr Tyr Ser Gly Ser Thr Asn Tyr Asn Pro Ser Leu Lys Ser 
1               5                   10                  15      


<210>  122
<211>  16
<212>  PRT
<213>  Homo sapiens

<400>  122

Leu Ile Tyr Thr Ser Gly Ser Thr Asn Tyr Asn Pro Ser Leu Lys Ser 
1               5                   10                  15      


<210>  123
<211>  11
<212>  PRT
<213>  Artificial

<220>
<223>  Consensus sequence


<220>
<221>  MISC_FEATURE
<222>  (5)..(5)
<223>  Xaa can be Gly or Val

<220>
<221>  MISC_FEATURE
<222>  (6)..(6)
<223>  Xaa can be Ile, Phe or Ser

<220>
<221>  MISC_FEATURE
<222>  (8)..(8)
<223>  Xaa can be Ser or Gly

<220>
<221>  MISC_FEATURE
<222>  (10)..(10)
<223>  Xaa can be  Phe or Leu.

<400>  123

Arg Ala Ser Gln Xaa Xaa Ser Xaa Trp Xaa Ala 
1               5                   10      


<210>  124
<211>  12
<212>  PRT
<213>  Artificial

<220>
<223>  Consensus sequence


<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  Xaa can be Asn or Ser

<400>  124

Thr Leu Xaa Ser Gly Tyr Ser Asp Tyr Lys Val Asp 
1               5                   10          


<210>  125
<211>  14
<212>  PRT
<213>  Artificial

<220>
<223>  Consensus sequence


<220>
<221>  MISC_FEATURE
<222>  (7)..(7)
<223>  Xaa can be  Ile or Thr

<400>  125

Thr Gly Ser Ser Ser Asn Xaa Gly Ala Gly Tyr Asp Val His 
1               5                   10                  


<210>  126
<211>  12
<212>  PRT
<213>  Artificial

<220>
<223>  Consensus sequence


<220>
<221>  MISC_FEATURE
<222>  (6)..(6)
<223>  Xaa can be Ile or Thr

<220>
<221>  MISC_FEATURE
<222>  (12)..(12)
<223>  Xaa can be Asp or Glu

<400>  126

Val Gly Thr Gly Gly Xaa Val Gly Ser Lys Gly Xaa 
1               5                   10          


<210>  127
<211>  7
<212>  PRT
<213>  Artificial

<220>
<223>  Consensus sequence


<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  Xaa can be Asn or Gly

<400>  127

Gly Ser Xaa Asn Arg Pro Ser 
1               5           


<210>  128
<211>  13
<212>  PRT
<213>  Artificial

<220>
<223>  Consensus sequence


<220>
<221>  MISC_FEATURE
<222>  (8)..(8)
<223>  Xaa can be Ser or Asn

<400>  128

Gly Ala Asp His Gly Ser Gly Xaa Asn Phe Val Tyr Val 
1               5                   10              


<210>  129
<211>  7
<212>  PRT
<213>  Artificial

<220>
<223>  Consensus sequence


<220>
<221>  MISC_FEATURE
<222>  (7)..(7)
<223>  Xaa can be Ser or Thr

<400>  129

Ser Gly Gly Tyr Tyr Trp Xaa 
1               5           


<210>  130
<211>  5
<212>  PRT
<213>  Artificial

<220>
<223>  Consensus sequence


<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  Xaa can be Gly or Ala

<400>  130

Ser Tyr Xaa Met His 
1               5   


<210>  131
<211>  5
<212>  PRT
<213>  Artificial

<220>
<223>  Consensus sequence


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Xaa can be Ser or The

<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Xaa can be Ser or Thr

<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Xaa can be Ser or Thr

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa can be Tyr or Phe

<400>  131

Xaa Xaa Ser Met Asn 
1               5   


<210>  132
<211>  16
<212>  PRT
<213>  Artificial

<220>
<223>  Consensus sequence


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Xaa can be Tyr or His

<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  Xaa can be Thr or His

<220>
<221>  MISC_FEATURE
<222>  (7)..(7)
<223>  Xaa can be Ser or Asn

<220>
<221>  MISC_FEATURE
<222>  (8)..(8)
<223>  Xaa can be Thr or Ser

<400>  132

Xaa Ile Xaa Tyr Ser Gly Xaa Xaa Tyr Tyr Asn Pro Ser Leu Lys Ser 
1               5                   10                  15      


<210>  133
<211>  17
<212>  PRT
<213>  Artificial

<220>
<223>  Consensus sequence


<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  Xaa can be Phe or His

<220>
<221>  MISC_FEATURE
<222>  (8)..(8)
<223>  Xaa can be Leu or Thr

<400>  133

Val Ile Ser Xaa Asp Gly Ser Xaa Lys Tyr Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  134
<211>  17
<212>  PRT
<213>  Artificial

<220>
<223>  Consensus sequence


<220>
<221>  MISC_FEATURE
<222>  (5)..(5)
<223>  Xaa can be Arg or Ser

<220>
<221>  MISC_FEATURE
<222>  (9)..(9)
<223>  Xaa can be Ile or Arg

<220>
<221>  MISC_FEATURE
<222>  (11)..(11)
<223>  Xaa can be Ile, His or Try

<400>  134

Tyr Ile Ser Ser Xaa Ser Ser Thr Xaa Tyr Xaa Ala Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  135
<211>  17
<212>  PRT
<213>  Artificial

<220>
<223>  Consensus sequence


<220>
<221>  MISC_FEATURE
<222>  (9)..(9)
<223>  Xaa can be Lys or Glu

<400>  135

Val Ile Trp Tyr Asp Gly Ser Asn Xaa Tyr Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  136
<211>  10
<212>  PRT
<213>  Artificial

<220>
<223>  Consensus sequence


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Xaa can be Asn or Asp

<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  Xaa can be His, Tyr or Phe

<400>  136

Xaa Arg Gly Xaa Tyr Tyr Gly Met Asp Val 
1               5                   10  


<210>  137
<211>  16
<212>  PRT
<213>  Artificial

<220>
<223>  Consensus sequence


<220>
<221>  MISC_FEATURE
<222>  (7)..(7)
<223>  Xaa can be Gly or Phe

<220>
<221>  MISC_FEATURE
<222>  (8)..(8)
<223>  Xaa can be Phe or Trp

<220>
<221>  MISC_FEATURE
<222>  (9)..(9)
<223>  Xaa can be His or Gly

<220>
<221>  MISC_FEATURE
<222>  (14)..(14)
<223>  Xaa can be Leu and Met

<400>  137

Arg Ile Ala Ala Ala Gly Xaa Xaa Xaa Tyr Tyr Tyr Ala Xaa Asp Val 
1               5                   10                  15      


<210>  138
<211>  15
<212>  PRT
<213>  Artificial

<220>
<223>  Consensus sequence


<220>
<221>  MISC_FEATURE
<222>  (5)..(5)
<223>  Xaa can be Ser or Thr

<400>  138

Asp Arg Gly Tyr Xaa Ser Ser Trp Tyr Pro Asp Ala Phe Asp Ile 
1               5                   10                  15  


<210>  139
<211>  112
<212>  PRT
<213>  Artificial

<220>
<223>  Consensus Sequence


<220>
<221>  MISC_FEATURE
<222>  (29)..(29)
<223>  Xaa can be Ile or Thr

<220>
<221>  MISC_FEATURE
<222>  (41)..(41)
<223>  Xaa can be Val or Leu

<220>
<221>  MISC_FEATURE
<222>  (54)..(54)
<223>  Xaa can be Gly or Asn

<220>
<221>  MISC_FEATURE
<222>  (107)..(107)
<223>  Xaa can be Arg or Lys

<400>  139

Gln Ser Val Leu Thr Gln Pro Pro Ser Val Ser Gly Ala Pro Gly Gln 
1               5                   10                  15      


Arg Val Thr Ile Ser Cys Thr Gly Ser Ser Ser Asn Xaa Gly Ala Gly 
            20                  25                  30          


Tyr Asp Val His Trp Tyr Gln Gln Xaa Pro Gly Thr Ala Pro Lys Leu 
        35                  40                  45              


Leu Ile Tyr Gly Ser Xaa Asn Arg Pro Ser Gly Val Pro Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Thr Gly Leu 
65                  70                  75                  80  


Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Gln Ser Tyr Asp Ser Ser 
                85                  90                  95      


Leu Ser Gly Trp Val Phe Gly Gly Gly Thr Xaa Arg Leu Thr Val Leu 
            100                 105                 110         


<210>  140
<211>  120
<212>  PRT
<213>  Artificial

<220>
<223>  Consensus Sequence


<220>
<221>  MISC_FEATURE
<222>  (30)..(30)
<223>  Xaa can be And or Ser

<220>
<221>  MISC_FEATURE
<222>  (37)..(37)
<223>  Xaa can be Ser or Thr

<220>
<221>  MISC_FEATURE
<222>  (52)..(52)
<223>  Xaa can be Tyr or His

<220>
<221>  MISC_FEATURE
<222>  (54)..(54)
<223>  Xaa can be Tyr or His

<220>
<221>  MISC_FEATURE
<222>  (58)..(58)
<223>  Xaa can be Ser or Asn

<220>
<221>  MISC_FEATURE
<222>  (59)..(59)
<223>  Xaa can be Ser or Asn

<220>
<221>  MISC_FEATURE
<222>  (69)..(69)
<223>  Xaa can be Ser or Thr

<220>
<221>  MISC_FEATURE
<222>  (71)..(71)
<223>  Xaa can be Val or Ile

<220>
<221>  MISC_FEATURE
<222>  (77)..(77)
<223>  Xaa can be Ile or Met

<220>
<221>  MISC_FEATURE
<222>  (83)..(83)
<223>  Xaa can be Lys or Gln

<220>
<221>  MISC_FEATURE
<222>  (99)..(99)
<223>  Xaa can be Arg or Lys

<220>
<221>  MISC_FEATURE
<222>  (100)..(100)
<223>  Xaa can be Asp or Asn

<220>
<221>  MISC_FEATURE
<222>  (103)..(103)
<223>  Xaa can be His, Phe or Try

<400>  140

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gln 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Gly Ser Ile Xaa Ser Gly 
            20                  25                  30          


Gly Tyr Tyr Trp Xaa Trp Ile Arg Gln His Pro Gly Lys Gly Leu Glu 
        35                  40                  45              


Trp Ile Gly Xaa Ile Xaa Tyr Ser Gly Xaa Xaa Tyr Tyr Asn Pro Ser 
    50                  55                  60                  


Leu Lys Ser Arg Xaa Thr Xaa Ser Val Asp Thr Ser Xaa Asn Gln Phe 
65                  70                  75                  80  


Ser Leu Xaa Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr 
                85                  90                  95      


Cys Ala Xaa Xaa Arg Gly Xaa Tyr Tyr Gly Met Asp Val Trp Gly Gln 
            100                 105                 110         


Gly Thr Thr Val Thr Val Ser Ser 
        115                 120 


<210>  141
<211>  125
<212>  PRT
<213>  Artificial

<220>
<223>  Consensus Sequence


<220>
<221>  MISC_FEATURE
<222>  (23)..(23)
<223>  Xaa can be Ala or Val

<220>
<221>  MISC_FEATURE
<222>  (24)..(24)
<223>  Xaa can be Ala or Val

<220>
<221>  MISC_FEATURE
<222>  (31)..(31)
<223>  Xaa can be Thr or Ser

<220>
<221>  MISC_FEATURE
<222>  (32)..(32)
<223>  Xaa can be Tyr or Phe

<220>
<221>  MISC_FEATURE
<222>  (54)..(54)
<223>  Xaa can be Ser or Arg

<220>
<221>  MISC_FEATURE
<222>  (58)..(58)
<223>  Xaa can be Arg or Ile

<220>
<221>  MISC_FEATURE
<222>  (60)..(60)
<223>  Xaa can be His, Try or Ile

<220>
<221>  MISC_FEATURE
<222>  (105)..(105)
<223>  Xaa can be Pro or Gly

<220>
<221>  MISC_FEATURE
<222>  (106)..(106)
<223>  Xaa can be Trp or Phe

<220>
<221>  MISC_FEATURE
<222>  (107)..(107)
<223>  Xaa can be Gly or His

<220>
<221>  MISC_FEATURE
<222>  (112)..(112)
<223>  Xaa can be Met or Leu

<400>  141

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Xaa Xaa Ser Gly Phe Thr Phe Ser Xaa Xaa 
            20                  25                  30          


Ser Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Tyr Ile Ser Ser Xaa Ser Ser Thr Xaa Tyr Xaa Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Asp Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Arg Ile Ala Ala Ala Gly Xaa Xaa Xaa Tyr Tyr Tyr Ala Xaa 
            100                 105                 110         


Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 
        115                 120                 125 


<210>  142
<211>  121
<212>  PRT
<213>  Artificial

<220>
<223>  Consensus Sequence


<220>
<221>  MISC_FEATURE
<222>  (33)..(33)
<223>  Xaa can be Gly or Ala

<220>
<221>  MISC_FEATURE
<222>  (48)..(48)
<223>  Xaa can be Val or Leu

<220>
<221>  MISC_FEATURE
<222>  (49)..(49)
<223>  Xaa can be Ala or Ser

<220>
<221>  MISC_FEATURE
<222>  (53)..(53)
<223>  Xaa can be Phe or His

<220>
<221>  MISC_FEATURE
<222>  (57)..(57)
<223>  Xaa can be Leu or Ile

<400>  142

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Xaa Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Xaa 
        35                  40                  45              


Xaa Val Ile Ser Xaa Asp Gly Ser Xaa Lys Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Glu Arg Thr Thr Leu Ser Gly Ser Tyr Phe Asp Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120     


<210>  143
<211>  124
<212>  PRT
<213>  Artificial

<220>
<223>  Consensus Sequence


<220>
<221>  MISC_FEATURE
<222>  (58)..(58)
<223>  Xaa can be Glu or Lys

<220>
<221>  MISC_FEATURE
<222>  (103)..(103)
<223>  Xaa can be Thr or Ser

<400>  143

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Val Ile Trp Tyr Asp Gly Ser Asn Xaa Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Arg Gly Tyr Xaa Ser Ser Trp Tyr Pro Asp Ala Phe Asp 
            100                 105                 110         


Ile Trp Gly Gln Gly Thr Met Val Thr Val Ser Ser 
        115                 120                 


<210>  144
<211>  1026
<212>  DNA
<213>  Homo sapiens

<400>  144
aactcggtga acaactgagg gaaccaaacc agagacgcgc tgaacagaga gaatcaggct       60

caaagcaagt ggaagtgggc agagattcca ccaggactgg tgcaaggcgc agagccagcc      120

agatttgaga agaaggcaaa aagatgctgg ggagcagagc tgtaatgctg ctgttgctgc      180

tgccctggac agctcagggc agagctgtgc ctgggggcag cagccctgcc tggactcagt      240

gccagcagct ttcacagaag ctctgcacac tggcctggag tgcacatcca ctagtgggac      300

acatggatct aagagaagag ggagatgaag agactacaaa tgatgttccc catatccagt      360

gtggagatgg ctgtgacccc caaggactca gggacaacag tcagttctgc ttgcaaagga      420

tccaccaggg tctgattttt tatgagaagc tgctaggatc ggatattttc acaggggagc      480

cttctctgct ccctgatagc cctgtgggcc agcttcatgc ctccctactg ggcctcagcc      540

aactcctgca gcctgagggt caccactggg agactcagca gattccaagc ctcagtccca      600

gccagccatg gcagcgtctc cttctccgct tcaaaatcct tcgcagcctc caggcctttg      660

tggctgtagc cgcccgggtc tttgcccatg gagcagcaac cctgagtccc taaaggcagc      720

agctcaagga tggcactcag atctccatgg cccagcaagg ccaagataaa tctaccaccc      780

caggcacctg tgagccaaca ggttaattag tccattaatt ttagtgggac ctgcatatgt      840

tgaaaattac caatactgac tgacatgtga tgctgaccta tgataaggtt gagtatttat      900

tagatgggaa gggaaatttg gggattattt atcctcctgg ggacagtttg gggaggatta      960

tttattgtat ttatattgaa ttatgtactt ttttcaataa agtcttattt ttgtggctaa     1020

aaaaaa                                                                1026


<210>  145
<211>  189
<212>  PRT
<213>  Homo sapiens

<400>  145

Met Leu Gly Ser Arg Ala Val Met Leu Leu Leu Leu Leu Pro Trp Thr 
1               5                   10                  15      


Ala Gln Gly Arg Ala Val Pro Gly Gly Ser Ser Pro Ala Trp Thr Gln 
            20                  25                  30          


Cys Gln Gln Leu Ser Gln Lys Leu Cys Thr Leu Ala Trp Ser Ala His 
        35                  40                  45              


Pro Leu Val Gly His Met Asp Leu Arg Glu Glu Gly Asp Glu Glu Thr 
    50                  55                  60                  


Thr Asn Asp Val Pro His Ile Gln Cys Gly Asp Gly Cys Asp Pro Gln 
65                  70                  75                  80  


Gly Leu Arg Asp Asn Ser Gln Phe Cys Leu Gln Arg Ile His Gln Gly 
                85                  90                  95      


Leu Ile Phe Tyr Glu Lys Leu Leu Gly Ser Asp Ile Phe Thr Gly Glu 
            100                 105                 110         


Pro Ser Leu Leu Pro Asp Ser Pro Val Gly Gln Leu His Ala Ser Leu 
        115                 120                 125             


Leu Gly Leu Ser Gln Leu Leu Gln Pro Glu Gly His His Trp Glu Thr 
    130                 135                 140                 


Gln Gln Ile Pro Ser Leu Ser Pro Ser Gln Pro Trp Gln Arg Leu Leu 
145                 150                 155                 160 


Leu Arg Phe Lys Ile Leu Arg Ser Leu Gln Ala Phe Val Ala Val Ala 
                165                 170                 175     


Ala Arg Val Phe Ala His Gly Ala Ala Thr Leu Ser Pro 
            180                 185                 


<210>  146
<211>  1399
<212>  DNA
<213>  Homo sapiens

<400>  146
ctgtttcagg gccattggac tctccgtcct gcccagagca agatgtgtca ccagcagttg       60

gtcatctctt ggttttccct ggtttttctg gcatctcccc tcgtggccat atgggaactg      120

aagaaagatg tttatgtcgt agaattggat tggtatccgg atgcccctgg agaaatggtg      180

gtcctcacct gtgacacccc tgaagaagat ggtatcacct ggaccttgga ccagagcagt      240

gaggtcttag gctctggcaa aaccctgacc atccaagtca aagagtttgg agatgctggc      300

cagtacacct gtcacaaagg aggcgaggtt ctaagccatt cgctcctgct gcttcacaaa      360

aaggaagatg gaatttggtc cactgatatt ttaaaggacc agaaagaacc caaaaataag      420

acctttctaa gatgcgaggc caagaattat tctggacgtt tcacctgctg gtggctgacg      480

acaatcagta ctgatttgac attcagtgtc aaaagcagca gaggctcttc tgacccccaa      540

ggggtgacgt gcggagctgc tacactctct gcagagagag tcagagggga caacaaggag      600

tatgagtact cagtggagtg ccaggaggac agtgcctgcc cagctgctga ggagagtctg      660

cccattgagg tcatggtgga tgccgttcac aagctcaagt atgaaaacta caccagcagc      720

ttcttcatca gggacatcat caaacctgac ccacccaaga acttgcagct gaagccatta      780

aagaattctc ggcaggtgga ggtcagctgg gagtaccctg acacctggag tactccacat      840

tcctacttct ccctgacatt ctgcgttcag gtccagggca agagcaagag agaaaagaaa      900

gatagagtct tcacggacaa gacctcagcc acggtcatct gccgcaaaaa tgccagcatt      960

agcgtgcggg cccaggaccg ctactatagc tcatcttgga gcgaatgggc atctgtgccc     1020

tgcagttagg ttctgatcca ggatgaaaat ttggaggaaa agtggaagat attaagcaaa     1080

atgtttaaag acacaacgga atagacccaa aaagataatt tctatctgat ttgctttaaa     1140

acgttttttt aggatcacaa tgatatcttt gctgtatttg tatagttaga tgctaaatgc     1200

tcattgaaac aatcagctaa tttatgtata gattttccag ctctcaagtt gccatgggcc     1260

ttcatgctat ttaaatattt aagtaattta tgtatttatt agtatattac tgttatttaa     1320

cgtttgtctg ccaggatgta tggaatgttt catactctta tgacctgatc catcaggatc     1380

agtccctatt atgcaaaat                                                  1399


<210>  147
<211>  328
<212>  PRT
<213>  Homo sapiens

<400>  147

Met Cys His Gln Gln Leu Val Ile Ser Trp Phe Ser Leu Val Phe Leu 
1               5                   10                  15      


Ala Ser Pro Leu Val Ala Ile Trp Glu Leu Lys Lys Asp Val Tyr Val 
            20                  25                  30          


Val Glu Leu Asp Trp Tyr Pro Asp Ala Pro Gly Glu Met Val Val Leu 
        35                  40                  45              


Thr Cys Asp Thr Pro Glu Glu Asp Gly Ile Thr Trp Thr Leu Asp Gln 
    50                  55                  60                  


Ser Ser Glu Val Leu Gly Ser Gly Lys Thr Leu Thr Ile Gln Val Lys 
65                  70                  75                  80  


Glu Phe Gly Asp Ala Gly Gln Tyr Thr Cys His Lys Gly Gly Glu Val 
                85                  90                  95      


Leu Ser His Ser Leu Leu Leu Leu His Lys Lys Glu Asp Gly Ile Trp 
            100                 105                 110         


Ser Thr Asp Ile Leu Lys Asp Gln Lys Glu Pro Lys Asn Lys Thr Phe 
        115                 120                 125             


Leu Arg Cys Glu Ala Lys Asn Tyr Ser Gly Arg Phe Thr Cys Trp Trp 
    130                 135                 140                 


Leu Thr Thr Ile Ser Thr Asp Leu Thr Phe Ser Val Lys Ser Ser Arg 
145                 150                 155                 160 


Gly Ser Ser Asp Pro Gln Gly Val Thr Cys Gly Ala Ala Thr Leu Ser 
                165                 170                 175     


Ala Glu Arg Val Arg Gly Asp Asn Lys Glu Tyr Glu Tyr Ser Val Glu 
            180                 185                 190         


Cys Gln Glu Asp Ser Ala Cys Pro Ala Ala Glu Glu Ser Leu Pro Ile 
        195                 200                 205             


Glu Val Met Val Asp Ala Val His Lys Leu Lys Tyr Glu Asn Tyr Thr 
    210                 215                 220                 


Ser Ser Phe Phe Ile Arg Asp Ile Ile Lys Pro Asp Pro Pro Lys Asn 
225                 230                 235                 240 


Leu Gln Leu Lys Pro Leu Lys Asn Ser Arg Gln Val Glu Val Ser Trp 
                245                 250                 255     


Glu Tyr Pro Asp Thr Trp Ser Thr Pro His Ser Tyr Phe Ser Leu Thr 
            260                 265                 270         


Phe Cys Val Gln Val Gln Gly Lys Ser Lys Arg Glu Lys Lys Asp Arg 
        275                 280                 285             


Val Phe Thr Asp Lys Thr Ser Ala Thr Val Ile Cys Arg Lys Asn Ala 
    290                 295                 300                 


Ser Ile Ser Val Arg Ala Gln Asp Arg Tyr Tyr Ser Ser Ser Trp Ser 
305                 310                 315                 320 


Glu Trp Ala Ser Val Pro Cys Ser 
                325             


<210>  148
<211>  2826
<212>  DNA
<213>  Homo sapiens

<400>  148
acaagggtgg cagcctggct ctgaagtgga attatgtgct tcaaacaggt tgaaagaggg       60

aaacagtctt ttcctgcttc cagacatgaa tcaggtcact attcaatggg atgcagtaat      120

agccctttac atactcttca gctggtgtca tggaggaatt acaaatataa actgctctgg      180

ccacatctgg gtagaaccag ccacaatttt taagatgggt atgaatatct ctatatattg      240

ccaagcagca attaagaact gccaaccaag gaaacttcat ttttataaaa atggcatcaa      300

agaaagattt caaatcacaa ggattaataa aacaacagct cggctttggt ataaaaactt      360

tctggaacca catgcttcta tgtactgcac tgctgaatgt cccaaacatt ttcaagagac      420

actgatatgt ggaaaagaca tttcttctgg atatccgcca gatattcctg atgaagtaac      480

ctgtgtcatt tatgaatatt caggcaacat gacttgcacc tggaatgctg ggaagctcac      540

ctacatagac acaaaatacg tggtacatgt gaagagttta gagacagaag aagagcaaca      600

gtatctcacc tcaagctata ttaacatctc cactgattca ttacaaggtg gcaagaagta      660

cttggtttgg gtccaagcag caaacgcact aggcatggaa gagtcaaaac aactgcaaat      720

tcacctggat gatatagtga taccttctgc agccgtcatt tccagggctg agactataaa      780

tgctacagtg cccaagacca taatttattg ggatagtcaa acaacaattg aaaaggtttc      840

ctgtgaaatg agatacaagg ctacaacaaa ccaaacttgg aatgttaaag aatttgacac      900

caattttaca tatgtgcaac agtcagaatt ctacttggag ccaaacatta agtacgtatt      960

tcaagtgaga tgtcaagaaa caggcaaaag gtactggcag ccttggagtt cactgttttt     1020

tcataaaaca cctgaaacag ttccccaggt cacatcaaaa gcattccaac atgacacatg     1080

gaattctggg ctaacagttg cttccatctc tacagggcac cttacttctg acaacagagg     1140

agacattgga cttttattgg gaatgatcgt ctttgctgtt atgttgtcaa ttctttcttt     1200

gattgggata tttaacagat cattccgaac tgggattaaa agaaggatct tattgttaat     1260

accaaagtgg ctttatgaag atattcctaa tatgaaaaac agcaatgttg tgaaaatgct     1320

acaggaaaat agtgaactta tgaataataa ttccagtgag caggtcctat atgttgatcc     1380

catgattaca gagataaaag aaatcttcat cccagaacac aagcctacag actacaagaa     1440

ggagaataca ggacccctgg agacaagaga ctacccgcaa aactcgctat tcgacaatac     1500

tacagttgta tatattcctg atctcaacac tggatataaa ccccaaattt caaattttct     1560

gcctgaggga agccatctca gcaataataa tgaaattact tccttaacac ttaaaccacc     1620

agttgattcc ttagactcag gaaataatcc caggttacaa aagcatccta attttgcttt     1680

ttctgtttca agtgtgaatt cactaagcaa cacaatattt cttggagaat taagcctcat     1740

attaaatcaa ggagaatgca gttctcctga catacaaaac tcagtagagg aggaaaccac     1800

catgcttttg gaaaatgatt cacccagtga aactattcca gaacagaccc tgcttcctga     1860

tgaatttgtc tcctgtttgg ggatcgtgaa tgaggagttg ccatctatta atacttattt     1920

tccacaaaat attttggaaa gccacttcaa taggatttca ctcttggaaa agtagagctg     1980

tgtggtcaaa atcaatatga gaaagctgcc ttgcaatctg aacttgggtt ttccctgcaa     2040

tagaaattga attctgcctc tttttgaaaa aaatgtattc acatacaaat cttcacatgg     2100

acacatgttt tcatttccct tggataaata cctaggtagg ggattgctgg gccatatgat     2160

aagcatatgt ttcagttcta ccaatcttgt ttccagagta gtgacatttc tgtgctccta     2220

ccatcaccat gtaagaattc ccgggagctc catgcctttt taattttagc cattcttctg     2280

cctcatttct taaaattaga gaattaaggt cccgaaggtg gaacatgctt catggtcaca     2340

catacaggca caaaaacagc attatgtgga cgcctcatgt attttttata gagtcaacta     2400

tttcctcttt attttccctc attgaaagat gcaaaacagc tctctattgt gtacagaaag     2460

ggtaaataat gcaaaatacc tggtagtaaa ataaatgctg aaaattttcc tttaaaatag     2520

aatcattagg ccaggcgtgg tggctcatgc ttgtaatccc agcactttgg taggctgagg     2580

taggtggatc acctgaggtc aggagttcga gtccagcctg gccaatatgc tgaaaccctg     2640

tctctactaa aattacaaaa attagccggc catggtggca ggtgcttgta atcccagcta     2700

cttgggaggc tgaggcagga gaatcacttg aaccaggaag gcagaggttg cactgagctg     2760

agattgtgcc actgcactcc agcctgggca acaagagcaa aactctgtct ggaaaaaaaa     2820

aaaaaa                                                                2826


<210>  149
<211>  629
<212>  PRT
<213>  Homo sapiens

<400>  149

Met Asn Gln Val Thr Ile Gln Trp Asp Ala Val Ile Ala Leu Tyr Ile 
1               5                   10                  15      


Leu Phe Ser Trp Cys His Gly Gly Ile Thr Asn Ile Asn Cys Ser Gly 
            20                  25                  30          


His Ile Trp Val Glu Pro Ala Thr Ile Phe Lys Met Gly Met Asn Ile 
        35                  40                  45              


Ser Ile Tyr Cys Gln Ala Ala Ile Lys Asn Cys Gln Pro Arg Lys Leu 
    50                  55                  60                  


His Phe Tyr Lys Asn Gly Ile Lys Glu Arg Phe Gln Ile Thr Arg Ile 
65                  70                  75                  80  


Asn Lys Thr Thr Ala Arg Leu Trp Tyr Lys Asn Phe Leu Glu Pro His 
                85                  90                  95      


Ala Ser Met Tyr Cys Thr Ala Glu Cys Pro Lys His Phe Gln Glu Thr 
            100                 105                 110         


Leu Ile Cys Gly Lys Asp Ile Ser Ser Gly Tyr Pro Pro Asp Ile Pro 
        115                 120                 125             


Asp Glu Val Thr Cys Val Ile Tyr Glu Tyr Ser Gly Asn Met Thr Cys 
    130                 135                 140                 


Thr Trp Asn Ala Gly Lys Leu Thr Tyr Ile Asp Thr Lys Tyr Val Val 
145                 150                 155                 160 


His Val Lys Ser Leu Glu Thr Glu Glu Glu Gln Gln Tyr Leu Thr Ser 
                165                 170                 175     


Ser Tyr Ile Asn Ile Ser Thr Asp Ser Leu Gln Gly Gly Lys Lys Tyr 
            180                 185                 190         


Leu Val Trp Val Gln Ala Ala Asn Ala Leu Gly Met Glu Glu Ser Lys 
        195                 200                 205             


Gln Leu Gln Ile His Leu Asp Asp Ile Val Ile Pro Ser Ala Ala Val 
    210                 215                 220                 


Ile Ser Arg Ala Glu Thr Ile Asn Ala Thr Val Pro Lys Thr Ile Ile 
225                 230                 235                 240 


Tyr Trp Asp Ser Gln Thr Thr Ile Glu Lys Val Ser Cys Glu Met Arg 
                245                 250                 255     


Tyr Lys Ala Thr Thr Asn Gln Thr Trp Asn Val Lys Glu Phe Asp Thr 
            260                 265                 270         


Asn Phe Thr Tyr Val Gln Gln Ser Glu Phe Tyr Leu Glu Pro Asn Ile 
        275                 280                 285             


Lys Tyr Val Phe Gln Val Arg Cys Gln Glu Thr Gly Lys Arg Tyr Trp 
    290                 295                 300                 


Gln Pro Trp Ser Ser Leu Phe Phe His Lys Thr Pro Glu Thr Val Pro 
305                 310                 315                 320 


Gln Val Thr Ser Lys Ala Phe Gln His Asp Thr Trp Asn Ser Gly Leu 
                325                 330                 335     


Thr Val Ala Ser Ile Ser Thr Gly His Leu Thr Ser Asp Asn Arg Gly 
            340                 345                 350         


Asp Ile Gly Leu Leu Leu Gly Met Ile Val Phe Ala Val Met Leu Ser 
        355                 360                 365             


Ile Leu Ser Leu Ile Gly Ile Phe Asn Arg Ser Phe Arg Thr Gly Ile 
    370                 375                 380                 


Lys Arg Arg Ile Leu Leu Leu Ile Pro Lys Trp Leu Tyr Glu Asp Ile 
385                 390                 395                 400 


Pro Asn Met Lys Asn Ser Asn Val Val Lys Met Leu Gln Glu Asn Ser 
                405                 410                 415     


Glu Leu Met Asn Asn Asn Ser Ser Glu Gln Val Leu Tyr Val Asp Pro 
            420                 425                 430         


Met Ile Thr Glu Ile Lys Glu Ile Phe Ile Pro Glu His Lys Pro Thr 
        435                 440                 445             


Asp Tyr Lys Lys Glu Asn Thr Gly Pro Leu Glu Thr Arg Asp Tyr Pro 
    450                 455                 460                 


Gln Asn Ser Leu Phe Asp Asn Thr Thr Val Val Tyr Ile Pro Asp Leu 
465                 470                 475                 480 


Asn Thr Gly Tyr Lys Pro Gln Ile Ser Asn Phe Leu Pro Glu Gly Ser 
                485                 490                 495     


His Leu Ser Asn Asn Asn Glu Ile Thr Ser Leu Thr Leu Lys Pro Pro 
            500                 505                 510         


Val Asp Ser Leu Asp Ser Gly Asn Asn Pro Arg Leu Gln Lys His Pro 
        515                 520                 525             


Asn Phe Ala Phe Ser Val Ser Ser Val Asn Ser Leu Ser Asn Thr Ile 
    530                 535                 540                 


Phe Leu Gly Glu Leu Ser Leu Ile Leu Asn Gln Gly Glu Cys Ser Ser 
545                 550                 555                 560 


Pro Asp Ile Gln Asn Ser Val Glu Glu Glu Thr Thr Met Leu Leu Glu 
                565                 570                 575     


Asn Asp Ser Pro Ser Glu Thr Ile Pro Glu Gln Thr Leu Leu Pro Asp 
            580                 585                 590         


Glu Phe Val Ser Cys Leu Gly Ile Val Asn Glu Glu Leu Pro Ser Ile 
        595                 600                 605             


Asn Thr Tyr Phe Pro Gln Asn Ile Leu Glu Ser His Phe Asn Arg Ile 
    610                 615                 620                 


Ser Leu Leu Glu Lys 
625                 


<210>  150
<211>  2100
<212>  DNA
<213>  Homo sapiens

<400>  150
ggtggctgaa cctcgcaggt ggcagagagg ctcccctggg gctgtggggc tctacgtgga       60

tccgatggag ccgctggtga cctgggtggt ccccctcctc ttcctcttcc tgctgtccag      120

gcagggcgct gcctgcagaa ccagtgagtg ctgttttcag gacccgccat atccggatgc      180

agactcaggc tcggcctcgg gccctaggga cctgagatgc tatcggatat ccagtgatcg      240

ttacgagtgc tcctggcagt atgagggtcc cacagctggg gtcagccact tcctgcggtg      300

ttgccttagc tccgggcgct gctgctactt cgccgccggc tcagccacca ggctgcagtt      360

ctccgaccag gctggggtgt ctgtgctgta cactgtcaca ctctgggtgg aatcctgggc      420

caggaaccag acagagaagt ctcctgaggt gaccctgcag ctctacaact cagttaaata      480

tgagcctcct ctgggagaca tcaaggtgtc caagttggcc gggcagctgc gtatggagtg      540

ggagaccccg gataaccagg ttggtgctga ggtgcagttc cggcaccgga cacccagcag      600

cccatggaag ttgggcgact gcggacctca ggatgatgat actgagtcct gcctctgccc      660

cctggagatg aatgtggccc aggaattcca gctccgacga cggcagctgg ggagccaagg      720

aagttcctgg agcaagtgga gcagccccgt gtgcgttccc cctgaaaacc ccccacagcc      780

tcaggtgaga ttctcggtgg agcagctggg ccaggatggg aggaggcggc tgaccctgaa      840

agagcagcca acccagctgg agcttccaga aggctgtcaa gggctggcgc ctggcacgga      900

ggtcacttac cgactacagc tccacatgct gtcctgcccg tgtaaggcca aggccaccag      960

gaccctgcac ctggggaaga tgccctatct ctcgggtgct gcctacaacg tggctgtcat     1020

ctcctcgaac caatttggtc ctggcctgaa ccagacgtgg cacattcctg ccgacaccca     1080

cacagaacca gtggctctga atatcagcgt cggaaccaac gggaccacca tgtattggcc     1140

agcccgggct cagagcatga cgtattgcat tgaatggcag cctgtgggcc aggacggggg     1200

ccttgccacc tgcagcctga ctgcgccgca agacccggat ccggctggaa tggcaaccta     1260

cagctggagt cgagagtctg gggcaatggg gcaggaaaag tgttactaca ttaccatctt     1320

tgcctctgcg caccccgaga agctcacctt gtggtctacg gtcctgtcca cctaccactt     1380

tgggggcaat gcctcagcag ctgggacacc gcaccacgtc tcggtgaaga atcatagctt     1440

ggactctgtg tctgtggact gggcaccatc cctgctgagc acctgtcccg gcgtcctaaa     1500

ggagtatgtt gtccgctgcc gagatgaaga cagcaaacag gtgtcagagc atcccgtgca     1560

gcccacagag acccaagtta ccctcagtgg cctgcgggct ggtgtagcct acacggtgca     1620

ggtgcgagca gacacagcgt ggctgagggg tgtctggagc cagccccagc gcttcagcat     1680

cgaagtgcag gtttctgatt ggctcatctt cttcgcctcc ctggggagct tcctgagcat     1740

ccttctcgtg ggcgtccttg gctaccttgg cctgaacagg gccgcacggc acctgtgccc     1800

gccgctgccc acaccctgtg ccagctccgc cattgagttc cctggaggga aggagacttg     1860

gcagtggatc aacccagtgg acttccagga agaggcatcc ctgcaggagg ccctggtggt     1920

agagatgtcc tgggacaaag gcgagaggac tgagcctctc gagaagacag agctacctga     1980

gggtgcccct gagctggccc tggatacaga gttgtccttg gaggatggag acaggtgcaa     2040

ggccaagatg tgatcgttga ggctcagaga gggtgagtga ctcgcccgag gctacgtagc     2100


<210>  151
<211>  662
<212>  PRT
<213>  Homo sapiens

<400>  151

Met Glu Pro Leu Val Thr Trp Val Val Pro Leu Leu Phe Leu Phe Leu 
1               5                   10                  15      


Leu Ser Arg Gln Gly Ala Ala Cys Arg Thr Ser Glu Cys Cys Phe Gln 
            20                  25                  30          


Asp Pro Pro Tyr Pro Asp Ala Asp Ser Gly Ser Ala Ser Gly Pro Arg 
        35                  40                  45              


Asp Leu Arg Cys Tyr Arg Ile Ser Ser Asp Arg Tyr Glu Cys Ser Trp 
    50                  55                  60                  


Gln Tyr Glu Gly Pro Thr Ala Gly Val Ser His Phe Leu Arg Cys Cys 
65                  70                  75                  80  


Leu Ser Ser Gly Arg Cys Cys Tyr Phe Ala Ala Gly Ser Ala Thr Arg 
                85                  90                  95      


Leu Gln Phe Ser Asp Gln Ala Gly Val Ser Val Leu Tyr Thr Val Thr 
            100                 105                 110         


Leu Trp Val Glu Ser Trp Ala Arg Asn Gln Thr Glu Lys Ser Pro Glu 
        115                 120                 125             


Val Thr Leu Gln Leu Tyr Asn Ser Val Lys Tyr Glu Pro Pro Leu Gly 
    130                 135                 140                 


Asp Ile Lys Val Ser Lys Leu Ala Gly Gln Leu Arg Met Glu Trp Glu 
145                 150                 155                 160 


Thr Pro Asp Asn Gln Val Gly Ala Glu Val Gln Phe Arg His Arg Thr 
                165                 170                 175     


Pro Ser Ser Pro Trp Lys Leu Gly Asp Cys Gly Pro Gln Asp Asp Asp 
            180                 185                 190         


Thr Glu Ser Cys Leu Cys Pro Leu Glu Met Asn Val Ala Gln Glu Phe 
        195                 200                 205             


Gln Leu Arg Arg Arg Gln Leu Gly Ser Gln Gly Ser Ser Trp Ser Lys 
    210                 215                 220                 


Trp Ser Ser Pro Val Cys Val Pro Pro Glu Asn Pro Pro Gln Pro Gln 
225                 230                 235                 240 


Val Arg Phe Ser Val Glu Gln Leu Gly Gln Asp Gly Arg Arg Arg Leu 
                245                 250                 255     


Thr Leu Lys Glu Gln Pro Thr Gln Leu Glu Leu Pro Glu Gly Cys Gln 
            260                 265                 270         


Gly Leu Ala Pro Gly Thr Glu Val Thr Tyr Arg Leu Gln Leu His Met 
        275                 280                 285             


Leu Ser Cys Pro Cys Lys Ala Lys Ala Thr Arg Thr Leu His Leu Gly 
    290                 295                 300                 


Lys Met Pro Tyr Leu Ser Gly Ala Ala Tyr Asn Val Ala Val Ile Ser 
305                 310                 315                 320 


Ser Asn Gln Phe Gly Pro Gly Leu Asn Gln Thr Trp His Ile Pro Ala 
                325                 330                 335     


Asp Thr His Thr Glu Pro Val Ala Leu Asn Ile Ser Val Gly Thr Asn 
            340                 345                 350         


Gly Thr Thr Met Tyr Trp Pro Ala Arg Ala Gln Ser Met Thr Tyr Cys 
        355                 360                 365             


Ile Glu Trp Gln Pro Val Gly Gln Asp Gly Gly Leu Ala Thr Cys Ser 
    370                 375                 380                 


Leu Thr Ala Pro Gln Asp Pro Asp Pro Ala Gly Met Ala Thr Tyr Ser 
385                 390                 395                 400 


Trp Ser Arg Glu Ser Gly Ala Met Gly Gln Glu Lys Cys Tyr Tyr Ile 
                405                 410                 415     


Thr Ile Phe Ala Ser Ala His Pro Glu Lys Leu Thr Leu Trp Ser Thr 
            420                 425                 430         


Val Leu Ser Thr Tyr His Phe Gly Gly Asn Ala Ser Ala Ala Gly Thr 
        435                 440                 445             


Pro His His Val Ser Val Lys Asn His Ser Leu Asp Ser Val Ser Val 
    450                 455                 460                 


Asp Trp Ala Pro Ser Leu Leu Ser Thr Cys Pro Gly Val Leu Lys Glu 
465                 470                 475                 480 


Tyr Val Val Arg Cys Arg Asp Glu Asp Ser Lys Gln Val Ser Glu His 
                485                 490                 495     


Pro Val Gln Pro Thr Glu Thr Gln Val Thr Leu Ser Gly Leu Arg Ala 
            500                 505                 510         


Gly Val Ala Tyr Thr Val Gln Val Arg Ala Asp Thr Ala Trp Leu Arg 
        515                 520                 525             


Gly Val Trp Ser Gln Pro Gln Arg Phe Ser Ile Glu Val Gln Val Ser 
    530                 535                 540                 


Asp Trp Leu Ile Phe Phe Ala Ser Leu Gly Ser Phe Leu Ser Ile Leu 
545                 550                 555                 560 


Leu Val Gly Val Leu Gly Tyr Leu Gly Leu Asn Arg Ala Ala Arg His 
                565                 570                 575     


Leu Cys Pro Pro Leu Pro Thr Pro Cys Ala Ser Ser Ala Ile Glu Phe 
            580                 585                 590         


Pro Gly Gly Lys Glu Thr Trp Gln Trp Ile Asn Pro Val Asp Phe Gln 
        595                 600                 605             


Glu Glu Ala Ser Leu Gln Glu Ala Leu Val Val Glu Met Ser Trp Asp 
    610                 615                 620                 


Lys Gly Glu Arg Thr Glu Pro Leu Glu Lys Thr Glu Leu Pro Glu Gly 
625                 630                 635                 640 


Ala Pro Glu Leu Ala Leu Asp Thr Glu Leu Ser Leu Glu Asp Gly Asp 
                645                 650                 655     


Arg Cys Lys Ala Lys Met 
            660         


<210>  152
<211>  360
<212>  DNA
<213>  Homo sapiens

<400>  152
caggtgcagc tgcaggagtc gggcccagga ctggtgaagc cttcacagac cctgtccctc       60

acctgcactg tctctggtgg ctccatcagc agtggtggtt actactggag ctggatccgc      120

cagcacccag ggaagggcct ggagtggatt gggcacatcc attacagtgg gaacacctac      180

tacaacccgt ccctcaagag tcgagttacc atatcagtag acacgtctaa gaatcagttc      240

tccctgaaac tgagctctgt gactgccgcg gacacggccg tgtattactg tgcgcgaaat      300

cgcgggttct actacggtat ggacgtctgg ggccaaggga ccacggtcac cgtctcctca      360


<210>  153
<211>  120
<212>  PRT
<213>  Homo sapiens

<400>  153

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gln 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Gly Ser Ile Ser Ser Gly 
            20                  25                  30          


Gly Tyr Tyr Trp Ser Trp Ile Arg Gln His Pro Gly Lys Gly Leu Glu 
        35                  40                  45              


Trp Ile Gly His Ile His Tyr Ser Gly Asn Thr Tyr Tyr Asn Pro Ser 
    50                  55                  60                  


Leu Lys Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe 
65                  70                  75                  80  


Ser Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr 
                85                  90                  95      


Cys Ala Arg Asn Arg Gly Phe Tyr Tyr Gly Met Asp Val Trp Gly Gln 
            100                 105                 110         


Gly Thr Thr Val Thr Val Ser Ser 
        115                 120 


<210>  154
<211>  23
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Honeybee melittin signal

<400>  154

Met Lys Phe Leu Val Asn Val Ala Leu Val Phe Met Val Val Tyr Ile 
1               5                   10                  15      


Ser Tyr Ile Tyr Ala Ala Ala 
            20              


<210>  155
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  His Tag

<400>  155

His His His His His His 
1               5       


