                              Sequence Listing

<110> GENENTECH, INC. et al.
      Yan, Minhong
      Niessen, Kyle

<120> Activin Receptor Type IIB Compositions and Methods of Use

<130> P4384R1-WO


<150> US 61/254,990
<151> 2009-10-26

<160> 2

<210> 1
<211> 1107
<212> DNA
<213> Artificial sequence

<220>
<223> sequence is synthesized

<400> 1
 atgacggcgc cctgggtggc cctcgccctc ctctggggat cgctgtgcgc 50

 cggctctggg cgtggggagg ctgagacacg ggagtgcatc tactacaacg 100

 ccaactggga gctggagcgc accaaccaga gcggcctgga gcgctgcgaa 150

 ggcgagcagg acaagcggct gcactgctac gcctcctggc gcaacagctc 200

 tggcaccatc gagctcgtga agaagggctg ctggctagat gacttcaact 250

 gctacgatag gcaggagtgt gtggccactg aggagaaccc ccaggtgtac 300

 ttctgctgct gtgaaggcaa cttctgcaac gaacgcttca ctcatttgcc 350

 agaggctggg ggcccggaag tcacgtacga gccacccccg acagccccca 400

 ccaccggtgt caccgacaaa gctgcgcact atactctgtg cccaccgtgc 450

 ccagcacctg aactcctggg gggaccgtca gtcttcctct tccccccaaa 500

 acccaaggac accctcatga tctcccggac ccctgaggtc acatgcgtgg 550

 tggtggccgt gagccacgaa gaccctgagg tcaagttcaa ctggtacgtg 600

 gacggcgtgg aggtgcataa tgccaagaca aagccgcggg aggagcagta 650

 caacagcacg taccgtgtgg tcagcgtcct caccgtcctg caccaggact 700

 ggctgaatgg caaggagtac aagtgcaagg tctccaacaa agccctccca 750

 gcccccatcg agaaaaccat ctccaaagcc aaagggcagc cccgagaacc 800

 acaggtgtac accctgcccc catcccggga agagatgacc aagaaccagg 850

 tcagcctgac ctgcctggtc aaaggcttct atcccagcga catcgccgtg 900

 gagtgggaga gcaatgggca gccggagaac aactacaaga ccacgcctcc 950

 cgtgctggac tccgacggct ccttcttcct ctacagcaag ctcaccgtgg 1000

 acaagagcag gtggcagcag gggaacgtct tctcatgctc cgtgatgcat 1050

 gaggctctgc acaaccacta cacgcagaag agcctctccc tgtctccggg 1100

 taaatga 1107

<210> 2
<211> 368
<212> PRT
<213> Artificial sequence

<220>
<223> sequence is synthesized

<400> 2
 Met Thr Ala Pro Trp Val Ala Leu Ala Leu Leu Trp Gly Ser Leu
   1               5                  10                  15

 Cys Ala Gly Ser Gly Arg Gly Glu Ala Glu Thr Arg Glu Cys Ile
                  20                  25                  30

 Tyr Tyr Asn Ala Asn Trp Glu Leu Glu Arg Thr Asn Gln Ser Gly
                  35                  40                  45

 Leu Glu Arg Cys Glu Gly Glu Gln Asp Lys Arg Leu His Cys Tyr
                  50                  55                  60

 Ala Ser Trp Arg Asn Ser Ser Gly Thr Ile Glu Leu Val Lys Lys
                  65                  70                  75

 Gly Cys Trp Leu Asp Asp Phe Asn Cys Tyr Asp Arg Gln Glu Cys
                  80                  85                  90

 Val Ala Thr Glu Glu Asn Pro Gln Val Tyr Phe Cys Cys Cys Glu
                  95                 100                 105

 Gly Asn Phe Cys Asn Glu Arg Phe Thr His Leu Pro Glu Ala Gly
                 110                 115                 120

 Gly Pro Glu Val Thr Tyr Glu Pro Pro Pro Thr Ala Pro Thr Thr
                 125                 130                 135

 Gly Val Thr Asp Lys Ala Ala His Tyr Thr Leu Cys Pro Pro Cys
                 140                 145                 150

 Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro
                 155                 160                 165

 Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val
                 170                 175                 180

 Thr Cys Val Val Val Ala Val Ser His Glu Asp Pro Glu Val Lys
                 185                 190                 195

 Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr
                 200                 205                 210

 Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser
                 215                 220                 225

 Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr
                 230                 235                 240

 Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys
                 245                 250                 255

 Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr
                 260                 265                 270

 Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser
                 275                 280                 285

 Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val
                 290                 295                 300

 Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr
                 305                 310                 315

 Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys
                 320                 325                 330

 Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser
                 335                 340                 345

 Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys
                 350                 355                 360

 Ser Leu Ser Leu Ser Pro Gly Lys
                 365            

