                         SEQUENCE LISTING

<110>  Genepod Therapeutics AB
 
<120>  Novel rAAV Vector Construct

<130>  P2220PC00

<150>  61/259,502
<151>  2009-11-09

<160>  22    

<170>  PatentIn version 3.5

<210>  1
<211>  250
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(250)
<223>  GTP cyclohydrolase 1

<400>  1

Met Glu Lys Gly Pro Val Arg Ala Pro Ala Glu Lys Pro Arg Gly Ala 
1               5                   10                  15      


Arg Cys Ser Asn Gly Phe Pro Glu Arg Asp Pro Pro Arg Pro Gly Pro 
            20                  25                  30          


Ser Arg Pro Ala Glu Lys Pro Pro Arg Pro Glu Ala Lys Ser Ala Gln 
        35                  40                  45              


Pro Ala Asp Gly Trp Lys Gly Glu Arg Pro Arg Ser Glu Glu Asp Asn 
    50                  55                  60                  


Glu Leu Asn Leu Pro Asn Leu Ala Ala Ala Tyr Ser Ser Ile Leu Ser 
65                  70                  75                  80  


Ser Leu Gly Glu Asn Pro Gln Arg Gln Gly Leu Leu Lys Thr Pro Trp 
                85                  90                  95      


Arg Ala Ala Ser Ala Met Gln Phe Phe Thr Lys Gly Tyr Gln Glu Thr 
            100                 105                 110         


Ile Ser Asp Val Leu Asn Asp Ala Ile Phe Asp Glu Asp His Asp Glu 
        115                 120                 125             


Met Val Ile Val Lys Asp Ile Asp Met Phe Ser Met Cys Glu His His 
    130                 135                 140                 


Leu Val Pro Phe Val Gly Lys Val His Ile Gly Tyr Leu Pro Asn Lys 
145                 150                 155                 160 


Gln Val Leu Gly Leu Ser Lys Leu Ala Arg Ile Val Glu Ile Tyr Ser 
                165                 170                 175     


Arg Arg Leu Gln Val Gln Glu Arg Leu Thr Lys Gln Ile Ala Val Ala 
            180                 185                 190         


Ile Thr Glu Ala Leu Arg Pro Ala Gly Val Gly Val Val Val Glu Ala 
        195                 200                 205             


Thr His Met Cys Met Val Met Arg Gly Val Gln Lys Met Asn Ser Lys 
    210                 215                 220                 


Thr Val Thr Ser Thr Met Leu Gly Val Phe Arg Glu Asp Pro Lys Thr 
225                 230                 235                 240 


Arg Glu Glu Phe Leu Thr Leu Ile Arg Ser 
                245                 250 


<210>  2
<211>  213
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(213)
<223>  GTP cyclohydrolase 1 Isoform GCH-2

<400>  2

Met Glu Lys Gly Pro Val Arg Ala Pro Ala Glu Lys Pro Arg Gly Ala 
1               5                   10                  15      


Arg Cys Ser Asn Gly Phe Pro Glu Arg Asp Pro Pro Arg Pro Gly Pro 
            20                  25                  30          


Ser Arg Pro Ala Glu Lys Pro Pro Arg Pro Glu Ala Lys Ser Ala Gln 
        35                  40                  45              


Pro Ala Asp Gly Trp Lys Gly Glu Arg Pro Arg Ser Glu Glu Asp Asn 
    50                  55                  60                  


Glu Leu Asn Leu Pro Asn Leu Ala Ala Ala Tyr Ser Ser Ile Leu Ser 
65                  70                  75                  80  


Ser Leu Gly Glu Asn Pro Gln Arg Gln Gly Leu Leu Lys Thr Pro Trp 
                85                  90                  95      


Arg Ala Ala Ser Ala Met Gln Phe Phe Thr Lys Gly Tyr Gln Glu Thr 
            100                 105                 110         


Ile Ser Asp Val Leu Asn Asp Ala Ile Phe Asp Glu Asp His Asp Glu 
        115                 120                 125             


Met Val Ile Val Lys Asp Ile Asp Met Phe Ser Met Cys Glu His His 
    130                 135                 140                 


Leu Val Pro Phe Val Gly Lys Val His Ile Gly Tyr Leu Pro Asn Lys 
145                 150                 155                 160 


Gln Val Leu Gly Leu Ser Lys Leu Ala Arg Ile Val Glu Ile Tyr Ser 
                165                 170                 175     


Arg Arg Leu Gln Val Gln Glu Arg Leu Thr Lys Gln Ile Ala Val Ala 
            180                 185                 190         


Ile Thr Glu Ala Leu Arg Pro Ala Gly Val Gly Val Val Val Glu Ala 
        195                 200                 205             


Thr Ser Ala Glu Pro 
    210             


<210>  3
<211>  209
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(209)
<223>  GTP cyclohydrolase 1 Isoform GCH-3

<400>  3

Met Glu Lys Gly Pro Val Arg Ala Pro Ala Glu Lys Pro Arg Gly Ala 
1               5                   10                  15      


Arg Cys Ser Asn Gly Phe Pro Glu Arg Asp Pro Pro Arg Pro Gly Pro 
            20                  25                  30          


Ser Arg Pro Ala Glu Lys Pro Pro Arg Pro Glu Ala Lys Ser Ala Gln 
        35                  40                  45              


Pro Ala Asp Gly Trp Lys Gly Glu Arg Pro Arg Ser Glu Glu Asp Asn 
    50                  55                  60                  


Glu Leu Asn Leu Pro Asn Leu Ala Ala Ala Tyr Ser Ser Ile Leu Ser 
65                  70                  75                  80  


Ser Leu Gly Glu Asn Pro Gln Arg Gln Gly Leu Leu Lys Thr Pro Trp 
                85                  90                  95      


Arg Ala Ala Ser Ala Met Gln Phe Phe Thr Lys Gly Tyr Gln Glu Thr 
            100                 105                 110         


Ile Ser Asp Val Leu Asn Asp Ala Ile Phe Asp Glu Asp His Asp Glu 
        115                 120                 125             


Met Val Ile Val Lys Asp Ile Asp Met Phe Ser Met Cys Glu His His 
    130                 135                 140                 


Leu Val Pro Phe Val Gly Lys Val His Ile Gly Tyr Leu Pro Asn Lys 
145                 150                 155                 160 


Gln Val Leu Gly Leu Ser Lys Leu Ala Arg Ile Val Glu Ile Tyr Ser 
                165                 170                 175     


Arg Arg Leu Gln Val Gln Glu Arg Leu Thr Lys Gln Ile Ala Val Ala 
            180                 185                 190         


Ile Thr Glu Ala Leu Arg Pro Ala Gly Val Gly Val Val Val Glu Ala 
        195                 200                 205             


Thr 
    


<210>  4
<211>  233
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(233)
<223>  GTP cyclohydrolase 1 Isoform GCH-4

<400>  4

Met Glu Lys Gly Pro Val Arg Ala Pro Ala Glu Lys Pro Arg Gly Ala 
1               5                   10                  15      


Arg Cys Ser Asn Gly Phe Pro Glu Arg Asp Pro Pro Arg Pro Gly Pro 
            20                  25                  30          


Ser Arg Pro Ala Glu Lys Pro Pro Arg Pro Glu Ala Lys Ser Ala Gln 
        35                  40                  45              


Pro Ala Asp Gly Trp Lys Gly Glu Arg Pro Arg Ser Glu Glu Asp Asn 
    50                  55                  60                  


Glu Leu Asn Leu Pro Asn Leu Ala Ala Ala Tyr Ser Ser Ile Leu Ser 
65                  70                  75                  80  


Ser Leu Gly Glu Asn Pro Gln Arg Gln Gly Leu Leu Lys Thr Pro Trp 
                85                  90                  95      


Arg Ala Ala Ser Ala Met Gln Phe Phe Thr Lys Gly Tyr Gln Glu Thr 
            100                 105                 110         


Ile Ser Asp Val Leu Asn Asp Ala Ile Phe Asp Glu Asp His Asp Glu 
        115                 120                 125             


Met Val Ile Val Lys Asp Ile Asp Met Phe Ser Met Cys Glu His His 
    130                 135                 140                 


Leu Val Pro Phe Val Gly Lys Val His Ile Gly Tyr Leu Pro Asn Lys 
145                 150                 155                 160 


Gln Val Leu Gly Leu Ser Lys Leu Ala Arg Ile Val Glu Ile Tyr Ser 
                165                 170                 175     


Arg Arg Leu Gln Val Gln Glu Arg Leu Thr Lys Gln Ile Ala Val Ala 
            180                 185                 190         


Ile Thr Glu Ala Leu Arg Pro Ala Gly Val Gly Val Val Val Glu Ala 
        195                 200                 205             


Thr Lys Ser Asn Lys Tyr Asn Lys Gly Leu Ser Pro Leu Leu Ser Ser 
    210                 215                 220                 


Cys His Leu Phe Val Ala Ile Leu Lys 
225                 230             


<210>  5
<211>  241
<212>  PRT
<213>  Rattus norvegicus


<220>
<221>  MISC_FEATURE
<222>  (1)..(241)
<223>  GTP cyclohydrolase 1

<400>  5

Met Glu Lys Pro Arg Gly Val Arg Cys Thr Asn Gly Phe Pro Glu Arg 
1               5                   10                  15      


Glu Leu Pro Arg Pro Gly Ala Ser Arg Pro Ala Glu Lys Ser Arg Pro 
            20                  25                  30          


Pro Glu Ala Lys Gly Ala Gln Pro Ala Asp Ala Trp Lys Ala Gly Arg 
        35                  40                  45              


Pro Arg Ser Glu Glu Asp Asn Glu Leu Asn Leu Pro Asn Leu Ala Ala 
    50                  55                  60                  


Ala Tyr Ser Ser Ile Leu Arg Ser Leu Gly Glu Asp Pro Gln Arg Gln 
65                  70                  75                  80  


Gly Leu Leu Lys Thr Pro Trp Arg Ala Ala Thr Ala Met Gln Phe Phe 
                85                  90                  95      


Thr Lys Gly Tyr Gln Glu Thr Ile Ser Asp Val Leu Asn Asp Ala Ile 
            100                 105                 110         


Phe Asp Glu Asp His Asp Glu Met Val Ile Val Lys Asp Ile Asp Met 
        115                 120                 125             


Phe Ser Met Cys Glu His His Leu Val Pro Phe Val Gly Arg Val His 
    130                 135                 140                 


Ile Gly Tyr Leu Pro Asn Lys Gln Val Leu Gly Leu Ser Lys Leu Ala 
145                 150                 155                 160 


Arg Ile Val Glu Ile Tyr Ser Arg Arg Leu Gln Val Gln Glu Arg Leu 
                165                 170                 175     


Thr Lys Gln Ile Ala Val Ala Ile Thr Glu Ala Leu Gln Pro Ala Gly 
            180                 185                 190         


Val Gly Val Val Ile Glu Ala Thr His Met Cys Met Val Met Arg Gly 
        195                 200                 205             


Val Gln Lys Met Asn Ser Lys Thr Val Thr Ser Thr Met Leu Gly Val 
    210                 215                 220                 


Phe Arg Glu Asp Pro Lys Thr Arg Glu Glu Phe Leu Thr Leu Ile Arg 
225                 230                 235                 240 


Ser 
    


<210>  6
<211>  241
<212>  PRT
<213>  Mus musculus


<220>
<221>  MISC_FEATURE
<222>  (1)..(241)
<223>  GTP cyclohydrolase 1

<400>  6

Met Glu Lys Pro Arg Gly Val Arg Cys Thr Asn Gly Phe Ser Glu Arg 
1               5                   10                  15      


Glu Leu Pro Arg Pro Gly Ala Ser Pro Pro Ala Glu Lys Ser Arg Pro 
            20                  25                  30          


Pro Glu Ala Lys Gly Ala Gln Pro Ala Asp Ala Trp Lys Ala Gly Arg 
        35                  40                  45              


His Arg Ser Glu Glu Glu Asn Gln Val Asn Leu Pro Lys Leu Ala Ala 
    50                  55                  60                  


Ala Tyr Ser Ser Ile Leu Leu Ser Leu Gly Glu Asp Pro Gln Arg Gln 
65                  70                  75                  80  


Gly Leu Leu Lys Thr Pro Trp Arg Ala Ala Thr Ala Met Gln Tyr Phe 
                85                  90                  95      


Thr Lys Gly Tyr Gln Glu Thr Ile Ser Asp Val Leu Asn Asp Ala Ile 
            100                 105                 110         


Phe Asp Glu Asp His Asp Glu Met Val Ile Val Lys Asp Ile Asp Met 
        115                 120                 125             


Phe Ser Met Cys Glu His His Leu Val Pro Phe Val Gly Arg Val His 
    130                 135                 140                 


Ile Gly Tyr Leu Pro Asn Lys Gln Val Leu Gly Leu Ser Lys Leu Ala 
145                 150                 155                 160 


Arg Ile Val Glu Ile Tyr Ser Arg Arg Leu Gln Val Gln Glu Arg Leu 
                165                 170                 175     


Thr Lys Gln Ile Ala Val Ala Ile Thr Glu Ala Leu Gln Pro Ala Gly 
            180                 185                 190         


Val Gly Val Val Ile Glu Ala Thr His Met Cys Met Val Met Arg Gly 
        195                 200                 205             


Val Gln Lys Met Asn Ser Lys Thr Val Thr Ser Thr Met Leu Gly Val 
    210                 215                 220                 


Phe Arg Glu Asp Pro Lys Thr Arg Glu Glu Phe Leu Thr Leu Ile Arg 
225                 230                 235                 240 


Ser 
    


<210>  7
<211>  496
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(496)
<223>  Tyrosine 3-hydroxylase

<400>  7

Met Pro Thr Pro Asp Ala Thr Thr Pro Gln Ala Lys Gly Phe Arg Arg 
1               5                   10                  15      


Ala Val Ser Glu Leu Asp Ala Lys Gln Ala Glu Ala Ile Met Ser Pro 
            20                  25                  30          


Arg Phe Ile Gly Arg Arg Gln Ser Leu Ile Glu Asp Ala Arg Lys Glu 
        35                  40                  45              


Arg Glu Ala Ala Val Ala Ala Ala Ala Ala Ala Val Pro Ser Glu Pro 
    50                  55                  60                  


Gly Asp Pro Leu Glu Ala Val Ala Phe Glu Glu Lys Glu Gly Lys Ala 
65                  70                  75                  80  


Val Leu Asn Leu Leu Phe Ser Pro Arg Ala Thr Lys Pro Ser Ala Leu 
                85                  90                  95      


Ser Arg Ala Val Lys Val Phe Glu Thr Phe Glu Ala Lys Ile His His 
            100                 105                 110         


Leu Glu Thr Arg Pro Ala Gln Arg Pro Arg Ala Gly Gly Pro His Leu 
        115                 120                 125             


Glu Tyr Phe Val Arg Leu Glu Val Arg Arg Gly Asp Leu Ala Ala Leu 
    130                 135                 140                 


Leu Ser Gly Val Arg Gln Val Ser Glu Asp Val Arg Ser Pro Ala Gly 
145                 150                 155                 160 


Pro Lys Val Pro Trp Phe Pro Arg Lys Val Ser Glu Leu Asp Lys Cys 
                165                 170                 175     


His His Leu Val Thr Lys Phe Asp Pro Asp Leu Asp Leu Asp His Pro 
            180                 185                 190         


Gly Phe Ser Asp Gln Val Tyr Arg Gln Arg Arg Lys Leu Ile Ala Glu 
        195                 200                 205             


Ile Ala Phe Gln Tyr Arg His Gly Asp Pro Ile Pro Arg Val Glu Tyr 
    210                 215                 220                 


Thr Ala Glu Glu Ile Ala Thr Trp Lys Glu Val Tyr Thr Thr Leu Lys 
225                 230                 235                 240 


Gly Leu Tyr Ala Thr His Ala Cys Gly Glu His Leu Glu Ala Phe Ala 
                245                 250                 255     


Leu Leu Glu Arg Phe Ser Gly Tyr Arg Glu Asp Asn Ile Pro Gln Leu 
            260                 265                 270         


Glu Asp Val Ser Arg Phe Leu Lys Glu Arg Thr Gly Phe Gln Leu Arg 
        275                 280                 285             


Pro Val Ala Gly Leu Leu Ser Ala Arg Asp Phe Leu Ala Ser Leu Ala 
    290                 295                 300                 


Phe Arg Val Phe Gln Cys Thr Gln Tyr Ile Arg His Ala Ser Ser Pro 
305                 310                 315                 320 


Met His Ser Pro Glu Pro Asp Cys Cys His Glu Leu Leu Gly His Val 
                325                 330                 335     


Pro Met Leu Ala Asp Arg Thr Phe Ala Gln Phe Ser Gln Asp Ile Gly 
            340                 345                 350         


Leu Ala Ser Leu Gly Ala Ser Asp Glu Glu Ile Glu Lys Leu Ser Thr 
        355                 360                 365             


Leu Tyr Trp Phe Thr Val Glu Phe Gly Leu Cys Lys Gln Asn Gly Glu 
    370                 375                 380                 


Val Lys Ala Tyr Gly Ala Gly Leu Leu Ser Ser Tyr Gly Glu Leu Leu 
385                 390                 395                 400 


His Cys Leu Ser Glu Glu Pro Glu Ile Arg Ala Phe Asp Pro Glu Ala 
                405                 410                 415     


Ala Ala Val Gln Pro Tyr Gln Asp Gln Thr Tyr Gln Ser Val Tyr Phe 
            420                 425                 430         


Val Ser Glu Ser Phe Ser Asp Ala Lys Asp Lys Leu Arg Ser Tyr Ala 
        435                 440                 445             


Ser Arg Ile Gln Arg Pro Phe Ser Val Lys Phe Asp Pro Tyr Thr Leu 
    450                 455                 460                 


Ala Ile Asp Val Leu Asp Ser Pro Gln Ala Val Arg Arg Ser Leu Glu 
465                 470                 475                 480 


Gly Val Gln Asp Glu Leu Asp Thr Leu Ala His Ala Leu Ser Ala Ile 
                485                 490                 495     


<210>  8
<211>  528
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(528)
<223>  Tyrosine 3-monooxygenase

<400>  8

Met Pro Thr Pro Asp Ala Thr Thr Pro Gln Ala Lys Gly Phe Arg Arg 
1               5                   10                  15      


Ala Val Ser Glu Leu Asp Ala Lys Gln Ala Glu Ala Ile Met Val Arg 
            20                  25                  30          


Gly Gln Gly Ala Pro Gly Pro Ser Leu Thr Gly Ser Pro Trp Pro Gly 
        35                  40                  45              


Thr Ala Ala Pro Ala Ala Ser Tyr Thr Pro Thr Pro Arg Ser Pro Arg 
    50                  55                  60                  


Phe Ile Gly Arg Arg Gln Ser Leu Ile Glu Asp Ala Arg Lys Glu Arg 
65                  70                  75                  80  


Glu Ala Ala Val Ala Ala Ala Ala Ala Ala Val Pro Ser Glu Pro Gly 
                85                  90                  95      


Asp Pro Leu Glu Ala Val Ala Phe Glu Glu Lys Glu Gly Lys Ala Val 
            100                 105                 110         


Leu Asn Leu Leu Phe Ser Pro Arg Ala Thr Lys Pro Ser Ala Leu Ser 
        115                 120                 125             


Arg Ala Val Lys Val Phe Glu Thr Phe Glu Ala Lys Ile His His Leu 
    130                 135                 140                 


Glu Thr Arg Pro Ala Gln Arg Pro Arg Ala Gly Gly Pro His Leu Glu 
145                 150                 155                 160 


Tyr Phe Val Arg Leu Glu Val Arg Arg Gly Asp Leu Ala Ala Leu Leu 
                165                 170                 175     


Ser Gly Val Arg Gln Val Ser Glu Asp Val Arg Ser Pro Ala Gly Pro 
            180                 185                 190         


Lys Val Pro Trp Phe Pro Arg Lys Val Ser Glu Leu Asp Lys Cys His 
        195                 200                 205             


His Leu Val Thr Lys Phe Asp Pro Asp Leu Asp Leu Asp His Pro Gly 
    210                 215                 220                 


Phe Ser Asp Gln Val Tyr Arg Gln Arg Arg Lys Leu Ile Ala Glu Ile 
225                 230                 235                 240 


Ala Phe Gln Tyr Arg His Gly Asp Pro Ile Pro Arg Val Glu Tyr Thr 
                245                 250                 255     


Ala Glu Glu Ile Ala Thr Trp Lys Glu Val Tyr Thr Thr Leu Lys Gly 
            260                 265                 270         


Leu Tyr Ala Thr His Ala Cys Gly Glu His Leu Glu Ala Phe Ala Leu 
        275                 280                 285             


Leu Glu Arg Phe Ser Gly Tyr Arg Glu Asp Asn Ile Pro Gln Leu Glu 
    290                 295                 300                 


Asp Val Ser Arg Phe Leu Lys Glu Arg Thr Gly Phe Gln Leu Arg Pro 
305                 310                 315                 320 


Val Ala Gly Leu Leu Ser Ala Arg Asp Phe Leu Ala Ser Leu Ala Phe 
                325                 330                 335     


Arg Val Phe Gln Cys Thr Gln Tyr Ile Arg His Ala Ser Ser Pro Met 
            340                 345                 350         


His Ser Pro Glu Pro Asp Cys Cys His Glu Leu Leu Gly His Val Pro 
        355                 360                 365             


Met Leu Ala Asp Arg Thr Phe Ala Gln Phe Ser Gln Asp Ile Gly Leu 
    370                 375                 380                 


Ala Ser Leu Gly Ala Ser Asp Glu Glu Ile Glu Lys Leu Ser Thr Leu 
385                 390                 395                 400 


Tyr Trp Phe Thr Val Glu Phe Gly Leu Cys Lys Gln Asn Gly Glu Val 
                405                 410                 415     


Lys Ala Tyr Gly Ala Gly Leu Leu Ser Ser Tyr Gly Glu Leu Leu His 
            420                 425                 430         


Cys Leu Ser Glu Glu Pro Glu Ile Arg Ala Phe Asp Pro Glu Ala Ala 
        435                 440                 445             


Ala Val Gln Pro Tyr Gln Asp Gln Thr Tyr Gln Ser Val Tyr Phe Val 
    450                 455                 460                 


Ser Glu Ser Phe Ser Asp Ala Lys Asp Lys Leu Arg Ser Tyr Ala Ser 
465                 470                 475                 480 


Arg Ile Gln Arg Pro Phe Ser Val Lys Phe Asp Pro Tyr Thr Leu Ala 
                485                 490                 495     


Ile Asp Val Leu Asp Ser Pro Gln Ala Val Arg Arg Ser Leu Glu Gly 
            500                 505                 510         


Val Gln Asp Glu Leu Asp Thr Leu Ala His Ala Leu Ser Ala Ile Gly 
        515                 520                 525             


<210>  9
<211>  497
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(497)
<223>  Tyrosine hydroxylase

<400>  9

Met Pro Thr Pro Asp Ala Thr Thr Pro Gln Ala Lys Gly Phe Arg Arg 
1               5                   10                  15      


Ala Val Ser Glu Leu Asp Ala Lys Gln Ala Glu Ala Ile Met Ser Pro 
            20                  25                  30          


Arg Phe Ile Gly Arg Arg Gln Ser Leu Ile Glu Asp Ala Arg Lys Glu 
        35                  40                  45              


Arg Glu Ala Ala Val Ala Ala Ala Ala Ala Ala Val Pro Ser Glu Pro 
    50                  55                  60                  


Gly Asp Pro Leu Glu Ala Val Ala Phe Glu Glu Lys Glu Gly Lys Ala 
65                  70                  75                  80  


Met Leu Asn Leu Leu Phe Ser Pro Arg Ala Thr Lys Pro Ser Ala Leu 
                85                  90                  95      


Ser Arg Ala Val Lys Val Phe Glu Thr Phe Glu Ala Lys Ile His His 
            100                 105                 110         


Leu Glu Thr Arg Pro Ala Gln Arg Pro Arg Ala Gly Gly Pro His Leu 
        115                 120                 125             


Glu Tyr Phe Val Arg Leu Glu Val Arg Arg Gly Asp Leu Ala Ala Leu 
    130                 135                 140                 


Leu Ser Gly Val Arg Gln Val Ser Glu Asp Val Arg Ser Pro Ala Gly 
145                 150                 155                 160 


Pro Lys Val Pro Trp Phe Pro Arg Lys Val Ser Glu Leu Asp Lys Cys 
                165                 170                 175     


His His Leu Val Thr Lys Phe Asp Pro Asp Leu Asp Leu Asp His Pro 
            180                 185                 190         


Gly Phe Ser Asp Gln Val Tyr Arg Gln Arg Arg Lys Leu Ile Ala Glu 
        195                 200                 205             


Ile Ala Phe Gln Tyr Arg His Gly Asp Pro Ile Pro Arg Val Glu Tyr 
    210                 215                 220                 


Thr Ala Glu Glu Ile Ala Thr Trp Lys Glu Val Tyr Thr Thr Leu Lys 
225                 230                 235                 240 


Gly Leu Tyr Ala Thr His Ala Cys Gly Glu His Leu Glu Ala Phe Ala 
                245                 250                 255     


Leu Leu Glu Arg Phe Ser Gly Tyr Arg Glu Asp Asn Ile Pro Gln Leu 
            260                 265                 270         


Glu Asp Val Ser Arg Phe Leu Lys Glu Arg Thr Gly Phe Gln Leu Arg 
        275                 280                 285             


Pro Val Ala Gly Leu Leu Ser Ala Arg Asp Phe Leu Ala Ser Leu Ala 
    290                 295                 300                 


Phe Arg Val Phe Gln Cys Thr Gln Tyr Ile Arg His Ala Ser Ser Pro 
305                 310                 315                 320 


Met His Ser Pro Glu Pro Asp Cys Cys His Glu Leu Leu Gly His Val 
                325                 330                 335     


Pro Met Leu Ala Asp Arg Thr Phe Ala Gln Phe Ser Gln Asp Ile Gly 
            340                 345                 350         


Leu Ala Ser Leu Gly Ala Ser Asp Glu Glu Ile Glu Lys Leu Ser Thr 
        355                 360                 365             


Leu Tyr Trp Phe Thr Val Glu Phe Gly Leu Cys Lys Gln Asn Gly Glu 
    370                 375                 380                 


Val Lys Ala Tyr Gly Ala Gly Leu Leu Ser Ser Tyr Gly Glu Leu Leu 
385                 390                 395                 400 


His Cys Leu Ser Glu Glu Pro Glu Ile Arg Ala Phe Asp Pro Glu Ala 
                405                 410                 415     


Ala Ala Val Gln Pro Tyr Gln Asp Gln Thr Tyr Gln Ser Val Tyr Phe 
            420                 425                 430         


Val Ser Glu Ser Phe Ser Asp Ala Lys Asp Lys Leu Arg Ser Tyr Ala 
        435                 440                 445             


Ser Arg Ile Gln Arg Pro Phe Ser Val Lys Phe Asp Pro Tyr Thr Leu 
    450                 455                 460                 


Ala Ile Asp Val Leu Asp Ser Pro Gln Ala Val Arg Arg Ser Leu Glu 
465                 470                 475                 480 


Gly Val Gln Asp Glu Leu Asp Thr Leu Ala His Ala Leu Ser Ala Ile 
                485                 490                 495     


Gly 
    


<210>  10
<211>  501
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(501)
<223>  Tyrosine hydroxylase

<400>  10

Met Pro Thr Pro Asp Ala Thr Thr Pro Gln Ala Lys Gly Phe Arg Arg 
1               5                   10                  15      


Ala Val Ser Glu Leu Asp Ala Lys Gln Ala Glu Ala Ile Met Val Arg 
            20                  25                  30          


Gly Gln Ser Pro Arg Phe Ile Gly Arg Arg Gln Ser Leu Ile Glu Asp 
        35                  40                  45              


Ala Arg Lys Glu Arg Glu Ala Ala Val Ala Ala Ala Ala Ala Ala Val 
    50                  55                  60                  


Pro Ser Glu Pro Gly Asp Pro Leu Glu Ala Val Ala Phe Glu Glu Lys 
65                  70                  75                  80  


Glu Gly Lys Ala Met Leu Asn Leu Leu Phe Ser Pro Arg Ala Thr Lys 
                85                  90                  95      


Pro Ser Ala Leu Ser Arg Ala Val Lys Val Phe Glu Thr Phe Glu Ala 
            100                 105                 110         


Lys Ile His His Leu Glu Thr Arg Pro Ala Gln Arg Pro Arg Ala Gly 
        115                 120                 125             


Gly Pro His Leu Glu Tyr Phe Val Arg Leu Glu Val Arg Arg Gly Asp 
    130                 135                 140                 


Leu Ala Ala Leu Leu Ser Gly Val Arg Gln Val Ser Glu Asp Val Arg 
145                 150                 155                 160 


Ser Pro Ala Gly Pro Lys Val Pro Trp Phe Pro Arg Lys Val Ser Glu 
                165                 170                 175     


Leu Asp Lys Cys His His Leu Val Thr Lys Phe Asp Pro Asp Leu Asp 
            180                 185                 190         


Leu Asp His Pro Gly Phe Ser Asp Gln Val Tyr Arg Gln Arg Arg Lys 
        195                 200                 205             


Leu Ile Ala Glu Ile Ala Phe Gln Tyr Arg His Gly Asp Pro Ile Pro 
    210                 215                 220                 


Arg Val Glu Tyr Thr Ala Glu Glu Ile Ala Thr Trp Lys Glu Val Tyr 
225                 230                 235                 240 


Thr Thr Leu Lys Gly Leu Tyr Ala Thr His Ala Cys Gly Glu His Leu 
                245                 250                 255     


Glu Ala Phe Ala Leu Leu Glu Arg Phe Ser Gly Tyr Arg Glu Asp Asn 
            260                 265                 270         


Ile Pro Gln Leu Glu Asp Val Ser Arg Phe Leu Lys Glu Arg Thr Gly 
        275                 280                 285             


Phe Gln Leu Arg Pro Val Ala Gly Leu Leu Ser Ala Arg Asp Phe Leu 
    290                 295                 300                 


Ala Ser Leu Ala Phe Arg Val Phe Gln Cys Thr Gln Tyr Ile Arg His 
305                 310                 315                 320 


Ala Ser Ser Pro Met His Ser Pro Glu Pro Asp Cys Cys His Glu Leu 
                325                 330                 335     


Leu Gly His Val Pro Met Leu Ala Asp His Thr Phe Ala Gln Phe Ser 
            340                 345                 350         


Gln Asp Ile Gly Leu Ala Ser Leu Gly Ala Ser Asp Glu Glu Ile Glu 
        355                 360                 365             


Lys Leu Ser Thr Leu Tyr Trp Phe Thr Val Glu Phe Gly Leu Cys Lys 
    370                 375                 380                 


Gln Asn Gly Glu Val Lys Ala Tyr Gly Ala Gly Leu Leu Ser Ser Tyr 
385                 390                 395                 400 


Gly Glu Leu Leu His Cys Leu Ser Glu Glu Pro Glu Ile Arg Ala Phe 
                405                 410                 415     


Asp Pro Glu Ala Ala Ala Val Gln Pro Tyr Gln Asp Gln Thr Tyr Gln 
            420                 425                 430         


Ser Val Tyr Phe Val Ser Glu Ser Phe Ser Asp Ala Lys Asp Lys Leu 
        435                 440                 445             


Arg Ser Tyr Ala Ser Arg Ile Gln Arg Pro Phe Ser Val Lys Phe Asp 
    450                 455                 460                 


Pro Tyr Thr Leu Ala Ile Asp Val Leu Asp Ser Pro Gln Ala Val Arg 
465                 470                 475                 480 


Arg Ser Leu Glu Gly Val Gln Asp Glu Leu Asp Thr Leu Ala His Ala 
                485                 490                 495     


Leu Ser Ala Ile Gly 
            500     


<210>  11
<211>  528
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(528)
<223>  Tyrosine 3-monooxygenase

<400>  11

Met Pro Thr Pro Asp Ala Thr Thr Pro Gln Ala Lys Gly Phe Arg Arg 
1               5                   10                  15      


Ala Val Ser Glu Leu Asp Ala Lys Gln Ala Glu Ala Ile Met Val Arg 
            20                  25                  30          


Gly Gln Gly Ala Pro Gly Pro Ser Leu Thr Gly Ser Pro Trp Pro Gly 
        35                  40                  45              


Thr Ala Ala Pro Ala Ala Ser Tyr Thr Pro Thr Pro Arg Ser Pro Arg 
    50                  55                  60                  


Phe Ile Gly Arg Arg Gln Ser Leu Ile Glu Asp Ala Arg Lys Glu Arg 
65                  70                  75                  80  


Glu Ala Ala Val Ala Ala Ala Ala Ala Ala Val Pro Ser Glu Pro Gly 
                85                  90                  95      


Asp Pro Leu Glu Ala Val Ala Phe Glu Glu Lys Glu Gly Lys Ala Val 
            100                 105                 110         


Leu Asn Leu Leu Phe Ser Pro Arg Ala Thr Lys Pro Ser Ala Leu Ser 
        115                 120                 125             


Arg Ala Val Lys Val Phe Glu Thr Phe Glu Ala Lys Ile His His Leu 
    130                 135                 140                 


Glu Thr Arg Pro Ala Gln Arg Pro Arg Ala Gly Gly Pro His Leu Glu 
145                 150                 155                 160 


Tyr Phe Val Arg Leu Glu Val Arg Arg Gly Asp Leu Ala Ala Leu Leu 
                165                 170                 175     


Ser Gly Val Arg Gln Val Ser Glu Asp Val Arg Ser Pro Ala Gly Pro 
            180                 185                 190         


Lys Val Pro Trp Phe Pro Arg Lys Val Ser Glu Leu Asp Lys Cys His 
        195                 200                 205             


His Leu Val Thr Lys Phe Asp Pro Asp Leu Asp Leu Asp His Pro Gly 
    210                 215                 220                 


Phe Ser Asp Gln Val Tyr Arg Gln Arg Arg Lys Leu Ile Ala Glu Ile 
225                 230                 235                 240 


Ala Phe Gln Tyr Arg His Gly Asp Pro Ile Pro Arg Val Glu Tyr Thr 
                245                 250                 255     


Ala Glu Glu Ile Ala Thr Trp Lys Glu Val Tyr Thr Thr Leu Lys Gly 
            260                 265                 270         


Leu Tyr Ala Thr His Ala Cys Gly Glu His Leu Glu Ala Phe Ala Leu 
        275                 280                 285             


Leu Glu Arg Phe Ser Gly Tyr Arg Glu Asp Asn Ile Pro Gln Leu Glu 
    290                 295                 300                 


Asp Val Ser Arg Phe Leu Lys Glu Arg Thr Gly Phe Gln Leu Arg Pro 
305                 310                 315                 320 


Val Ala Gly Leu Leu Ser Ala Arg Asp Phe Leu Ala Ser Leu Ala Phe 
                325                 330                 335     


Arg Val Phe Gln Cys Thr Gln Tyr Ile Arg His Ala Ser Ser Pro Met 
            340                 345                 350         


His Ser Pro Glu Pro Asp Cys Cys His Glu Leu Leu Gly His Val Pro 
        355                 360                 365             


Met Leu Ala Asp Arg Thr Phe Ala Gln Phe Ser Gln Asp Ile Gly Leu 
    370                 375                 380                 


Ala Ser Leu Gly Ala Ser Asp Glu Glu Ile Glu Lys Leu Ser Thr Leu 
385                 390                 395                 400 


Tyr Trp Phe Thr Val Glu Phe Gly Leu Cys Lys Gln Asn Gly Glu Val 
                405                 410                 415     


Lys Ala Tyr Gly Ala Gly Leu Leu Ser Ser Tyr Gly Glu Leu Leu His 
            420                 425                 430         


Cys Leu Ser Glu Glu Pro Glu Ile Arg Ala Phe Asp Pro Glu Ala Ala 
        435                 440                 445             


Ala Val Gln Pro Tyr Gln Asp Gln Thr Tyr Gln Ser Val Tyr Phe Val 
    450                 455                 460                 


Ser Glu Ser Phe Ser Asp Ala Lys Asp Lys Leu Arg Ser Tyr Ala Ser 
465                 470                 475                 480 


Arg Ile Gln Arg Pro Phe Ser Val Lys Phe Asp Pro Tyr Thr Leu Ala 
                485                 490                 495     


Ile Asp Val Leu Asp Ser Pro Gln Ala Val Arg Arg Ser Leu Glu Gly 
            500                 505                 510         


Val Gln Asp Glu Leu Asp Thr Leu Ala His Ala Leu Ser Ala Ile Gly 
        515                 520                 525             


<210>  12
<211>  528
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(528)
<223>  Tyrosine 3-monooxygenase

<400>  12

Met Pro Thr Pro Asp Ala Thr Thr Pro Gln Ala Lys Gly Phe Arg Arg 
1               5                   10                  15      


Ala Val Ser Glu Leu Asp Ala Lys Gln Ala Glu Ala Ile Met Val Arg 
            20                  25                  30          


Gly Gln Gly Ala Pro Gly Pro Ser Leu Thr Gly Ser Pro Trp Pro Gly 
        35                  40                  45              


Thr Ala Ala Pro Ala Ala Ser Tyr Thr Pro Thr Pro Arg Ser Pro Arg 
    50                  55                  60                  


Phe Ile Gly Arg Arg Gln Ser Leu Ile Glu Asp Ala Arg Lys Glu Arg 
65                  70                  75                  80  


Glu Ala Ala Val Ala Ala Ala Ala Ala Ala Val Pro Ser Glu Pro Gly 
                85                  90                  95      


Asp Pro Leu Glu Ala Val Ala Phe Glu Glu Lys Glu Gly Lys Ala Val 
            100                 105                 110         


Leu Asn Leu Leu Phe Ser Pro Arg Ala Thr Lys Pro Ser Ala Leu Ser 
        115                 120                 125             


Arg Ala Val Lys Val Phe Glu Thr Phe Glu Ala Lys Ile His His Leu 
    130                 135                 140                 


Glu Thr Arg Pro Ala Gln Arg Pro Arg Ala Gly Gly Pro His Leu Glu 
145                 150                 155                 160 


Tyr Phe Val Arg Leu Glu Val Arg Arg Gly Asp Leu Ala Ala Leu Leu 
                165                 170                 175     


Ser Gly Val Arg Gln Val Ser Glu Asp Val Arg Ser Pro Ala Gly Pro 
            180                 185                 190         


Lys Val Pro Trp Phe Pro Arg Lys Val Ser Glu Leu Asp Lys Cys His 
        195                 200                 205             


His Leu Val Thr Lys Phe Asp Pro Asp Leu Asp Leu Asp His Pro Gly 
    210                 215                 220                 


Phe Ser Asp Gln Val Tyr Arg Gln Arg Arg Lys Leu Ile Ala Glu Ile 
225                 230                 235                 240 


Ala Phe Gln Tyr Arg His Gly Asp Pro Ile Pro Arg Val Glu Tyr Thr 
                245                 250                 255     


Ala Glu Glu Ile Ala Thr Trp Lys Glu Val Tyr Thr Thr Leu Lys Gly 
            260                 265                 270         


Leu Tyr Ala Thr His Ala Cys Gly Glu His Leu Glu Ala Phe Ala Leu 
        275                 280                 285             


Leu Glu Arg Phe Ser Gly Tyr Arg Glu Asp Asn Ile Pro Gln Leu Glu 
    290                 295                 300                 


Asp Val Ser Arg Phe Leu Lys Glu Arg Thr Gly Phe Gln Leu Arg Pro 
305                 310                 315                 320 


Val Ala Gly Leu Leu Ser Ala Arg Asp Phe Leu Ala Ser Leu Ala Phe 
                325                 330                 335     


Arg Val Phe Gln Cys Thr Gln Tyr Ile Arg His Ala Ser Ser Pro Met 
            340                 345                 350         


His Ser Pro Glu Pro Asp Cys Cys His Glu Leu Leu Gly His Val Pro 
        355                 360                 365             


Met Leu Ala Asp Arg Thr Phe Ala Gln Phe Ser Gln Asp Ile Gly Leu 
    370                 375                 380                 


Ala Ser Leu Gly Ala Ser Asp Glu Glu Ile Glu Lys Leu Ser Thr Leu 
385                 390                 395                 400 


Tyr Trp Phe Thr Val Glu Phe Gly Leu Cys Lys Gln Asn Gly Glu Val 
                405                 410                 415     


Lys Ala Tyr Gly Ala Gly Leu Leu Ser Ser Tyr Gly Glu Leu Leu His 
            420                 425                 430         


Cys Leu Ser Glu Glu Pro Glu Ile Arg Ala Phe Asp Pro Glu Ala Ala 
        435                 440                 445             


Ala Val Gln Pro Tyr Gln Asp Gln Thr Tyr Gln Ser Val Tyr Phe Val 
    450                 455                 460                 


Ser Glu Ser Phe Ser Asp Ala Lys Asp Lys Leu Arg Ser Tyr Ala Ser 
465                 470                 475                 480 


Arg Ile Gln Arg Pro Phe Ser Val Lys Phe Asp Pro Tyr Thr Leu Ala 
                485                 490                 495     


Ile Asp Val Leu Asp Ser Pro Gln Ala Val Arg Arg Ser Leu Glu Gly 
            500                 505                 510         


Val Gln Asp Glu Leu Asp Thr Leu Ala His Ala Leu Ser Ala Ile Gly 
        515                 520                 525             


<210>  13
<211>  498
<212>  PRT
<213>  Rattus norvegicus


<220>
<221>  MISC_FEATURE
<222>  (1)..(498)
<223>  Tyrosine 3-hydroxylase

<400>  13

Met Pro Thr Pro Ser Ala Pro Ser Pro Gln Pro Lys Gly Phe Arg Arg 
1               5                   10                  15      


Ala Val Ser Glu Gln Asp Ala Lys Gln Ala Glu Ala Val Thr Ser Pro 
            20                  25                  30          


Arg Phe Ile Gly Arg Arg Gln Ser Leu Ile Glu Asp Ala Arg Lys Glu 
        35                  40                  45              


Arg Glu Ala Ala Ala Ala Ala Ala Ala Ala Ala Val Ala Ser Ser Glu 
    50                  55                  60                  


Pro Gly Asn Pro Leu Glu Ala Val Val Phe Glu Glu Arg Asp Gly Asn 
65                  70                  75                  80  


Ala Val Leu Asn Leu Leu Phe Ser Leu Arg Gly Thr Lys Pro Ser Ser 
                85                  90                  95      


Leu Ser Arg Ala Val Lys Val Phe Glu Thr Phe Glu Ala Lys Ile His 
            100                 105                 110         


His Leu Glu Thr Arg Pro Ala Gln Arg Pro Leu Ala Gly Ser Pro His 
        115                 120                 125             


Leu Glu Tyr Phe Val Arg Phe Glu Val Pro Ser Gly Asp Leu Ala Ala 
    130                 135                 140                 


Leu Leu Ser Ser Val Arg Arg Val Ser Asp Asp Val Arg Ser Ala Arg 
145                 150                 155                 160 


Glu Asp Lys Val Pro Trp Phe Pro Arg Lys Val Ser Glu Leu Asp Lys 
                165                 170                 175     


Cys His His Leu Val Thr Lys Phe Asp Pro Asp Leu Asp Leu Asp His 
            180                 185                 190         


Pro Gly Phe Ser Asp Gln Val Tyr Arg Gln Arg Arg Lys Leu Ile Ala 
        195                 200                 205             


Glu Ile Ala Phe Gln Tyr Lys His Gly Glu Pro Ile Pro His Val Glu 
    210                 215                 220                 


Tyr Thr Ala Glu Glu Ile Ala Thr Trp Lys Glu Val Tyr Val Thr Leu 
225                 230                 235                 240 


Lys Gly Leu Tyr Ala Thr His Ala Cys Arg Glu His Leu Glu Gly Phe 
                245                 250                 255     


Gln Leu Leu Glu Arg Tyr Cys Gly Tyr Arg Glu Asp Ser Ile Pro Gln 
            260                 265                 270         


Leu Glu Asp Val Ser Arg Phe Leu Lys Glu Arg Thr Gly Phe Gln Leu 
        275                 280                 285             


Arg Pro Val Ala Gly Leu Leu Ser Ala Arg Asp Phe Leu Ala Ser Leu 
    290                 295                 300                 


Ala Phe Arg Val Phe Gln Cys Thr Gln Tyr Ile Arg His Ala Ser Ser 
305                 310                 315                 320 


Pro Met His Ser Pro Glu Pro Asp Cys Cys His Glu Leu Leu Gly His 
                325                 330                 335     


Val Pro Met Leu Ala Asp Arg Thr Phe Ala Gln Phe Ser Gln Asp Ile 
            340                 345                 350         


Gly Leu Ala Ser Leu Gly Ala Ser Asp Glu Glu Ile Glu Lys Leu Ser 
        355                 360                 365             


Thr Val Tyr Trp Phe Thr Val Glu Phe Gly Leu Cys Lys Gln Asn Gly 
    370                 375                 380                 


Glu Leu Lys Ala Tyr Gly Ala Gly Leu Leu Ser Ser Tyr Gly Glu Leu 
385                 390                 395                 400 


Leu His Ser Leu Ser Glu Glu Pro Glu Val Arg Ala Phe Asp Pro Asp 
                405                 410                 415     


Thr Ala Ala Val Gln Pro Tyr Gln Asp Gln Thr Tyr Gln Pro Val Tyr 
            420                 425                 430         


Phe Val Ser Glu Ser Phe Asn Asp Ala Lys Asp Lys Leu Arg Asn Tyr 
        435                 440                 445             


Ala Ser Arg Ile Gln Arg Pro Phe Ser Val Lys Phe Asp Pro Tyr Thr 
    450                 455                 460                 


Leu Ala Ile Asp Val Leu Asp Ser Pro His Thr Ile Gln Arg Ser Leu 
465                 470                 475                 480 


Glu Gly Val Gln Asp Glu Leu His Thr Leu Ala His Ala Leu Ser Ala 
                485                 490                 495     


Ile Ser 
        


<210>  14
<211>  498
<212>  PRT
<213>  Mus musculus


<220>
<221>  MISC_FEATURE
<222>  (1)..(498)
<223>  Tyrosine 3-hydroxylase

<400>  14

Met Pro Thr Pro Ser Ala Ser Ser Pro Gln Pro Lys Gly Phe Arg Arg 
1               5                   10                  15      


Ala Val Ser Glu Gln Asp Thr Lys Gln Ala Glu Ala Val Thr Ser Pro 
            20                  25                  30          


Arg Phe Ile Gly Arg Arg Gln Ser Leu Ile Glu Asp Ala Arg Lys Glu 
        35                  40                  45              


Arg Glu Ala Ala Ala Ala Ala Ala Ala Ala Ala Val Ala Ser Ala Glu 
    50                  55                  60                  


Pro Gly Asn Pro Leu Glu Ala Val Val Phe Glu Glu Arg Asp Gly Asn 
65                  70                  75                  80  


Ala Val Leu Asn Leu Leu Phe Ser Leu Arg Gly Thr Lys Pro Ser Ser 
                85                  90                  95      


Leu Ser Arg Ala Leu Lys Val Phe Glu Thr Phe Glu Ala Lys Ile His 
            100                 105                 110         


His Leu Glu Thr Arg Pro Ala Gln Arg Pro Leu Ala Gly Ser Pro His 
        115                 120                 125             


Leu Glu Tyr Phe Val Arg Phe Glu Val Pro Ser Gly Asp Leu Ala Ala 
    130                 135                 140                 


Leu Leu Ser Ser Val Arg Arg Val Ser Asp Asp Val Arg Ser Ala Arg 
145                 150                 155                 160 


Glu Asp Lys Val Pro Trp Phe Pro Arg Lys Val Ser Glu Leu Asp Lys 
                165                 170                 175     


Cys His His Leu Val Thr Lys Phe Asp Pro Asp Leu Asp Leu Asp His 
            180                 185                 190         


Pro Gly Phe Ser Asp Gln Ala Tyr Arg Gln Arg Arg Lys Leu Ile Ala 
        195                 200                 205             


Glu Ile Ala Phe Gln Tyr Lys Gln Gly Glu Pro Ile Pro His Val Glu 
    210                 215                 220                 


Tyr Thr Lys Glu Glu Ile Ala Thr Trp Lys Glu Val Tyr Ala Thr Leu 
225                 230                 235                 240 


Lys Gly Leu Tyr Ala Thr His Ala Cys Arg Glu His Leu Glu Ala Phe 
                245                 250                 255     


Gln Leu Leu Glu Arg Tyr Cys Gly Tyr Arg Glu Asp Ser Ile Pro Gln 
            260                 265                 270         


Leu Glu Asp Val Ser His Phe Leu Lys Glu Arg Thr Gly Phe Gln Leu 
        275                 280                 285             


Arg Pro Val Ala Gly Leu Leu Ser Ala Arg Asp Phe Leu Ala Ser Leu 
    290                 295                 300                 


Ala Phe Arg Val Phe Gln Cys Thr Gln Tyr Ile Arg His Ala Ser Ser 
305                 310                 315                 320 


Pro Met His Ser Pro Glu Pro Asp Cys Cys His Glu Leu Leu Gly His 
                325                 330                 335     


Val Pro Met Leu Ala Asp Arg Thr Phe Ala Gln Phe Ser Gln Asp Ile 
            340                 345                 350         


Gly Leu Ala Ser Leu Gly Ala Ser Asp Glu Glu Ile Glu Lys Leu Ser 
        355                 360                 365             


Thr Val Tyr Trp Phe Thr Val Glu Phe Gly Leu Cys Lys Gln Asn Gly 
    370                 375                 380                 


Glu Leu Lys Ala Tyr Gly Ala Gly Leu Leu Ser Ser Tyr Gly Glu Leu 
385                 390                 395                 400 


Leu His Ser Leu Ser Glu Glu Pro Glu Val Arg Ala Phe Asp Pro Asp 
                405                 410                 415     


Thr Ala Ala Val Gln Pro Tyr Gln Asp Gln Thr Tyr Gln Pro Val Tyr 
            420                 425                 430         


Phe Val Ser Glu Ser Phe Ser Asp Ala Lys Asp Lys Leu Arg Asn Tyr 
        435                 440                 445             


Ala Ser Arg Ile Gln Arg Pro Phe Ser Val Lys Phe Asp Pro Tyr Thr 
    450                 455                 460                 


Leu Ala Ile Asp Val Leu Asp Ser Pro His Thr Ile Arg Arg Ser Leu 
465                 470                 475                 480 


Glu Gly Val Gln Asp Glu Leu His Thr Leu Thr Gln Ala Leu Ser Ala 
                485                 490                 495     


Ile Ser 
        


<210>  15
<211>  145
<212>  DNA
<213>  adeno-associated virus 2


<220>
<221>  misc_feature
<222>  (1)..(145)
<223>  left terminal sequence

<400>  15
ttggccactc cctctctgcg cgctcgctcg ctcactgagg ccgggcgacc aaaggtcgcc       60

cgacgcccgg gctttgcccg ggcggcctca gtgagcgagc gagcgcgcag agagggagtg      120

gccaactcca tcactagggg ttcct                                            145


<210>  16
<211>  145
<212>  DNA
<213>  adeno-associated virus 2


<220>
<221>  misc_feature
<222>  (1)..(145)
<223>  right terminal sequence

<400>  16
aggaacccct agtgatggag ttggccactc cctctctgcg cgctcgctcg ctcactgagg       60

ccgcccgggc aaagcccggg cgtcgggcga cctttggtcg cccggcctca gtgagcgagc      120

gagcgcgcag agagggagtg gccaa                                            145


<210>  17
<211>  484
<212>  DNA
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (1)..(484)
<223>  Synapsin 1 (SYN1) promoter sequence

<400>  17
ctagactcta gctgcagagg gacctgcgta tgagtgcaag tgggttttag gaccaggatg       60

aggcggggtg ggggtgccta cctgacgacc gaccccgacc cactggacaa gcacccaacc      120

cccattcccc aaattgcgca tcccctatca gagaggggga ggggaaacag gatgcggcga      180

ggcgcgtgcg cactgccagc ttcagcaccg cggacagtgc cttcgccccc gcctggcggc      240

gcgcgccacc gccgcctcag cactgaaggc gcgctgacgt cactcgccgg tcccccgcaa      300

actccccttc ccggccacct tggtcgcgtc cgcgccgccg ccggcccagc cggaccgcac      360

cacgcgaggc gcgagatagg ggggcacggg cgcgaccatc tgcgctgcgg cgccggcgac      420

tcagcgctgc ctcagtctgc ggtgggcagc ggaggagtcg tgtcgtgcct gagagcgcag      480

tcga                                                                   484


<210>  18
<211>  748
<212>  DNA
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (1)..(748)
<223>  GTP cyclohydrolase 1 (GCH1), transcript variant 1

<400>  18
atggagaagg gccctgtgcg ggcaccggcg gagaagccgc ggggcgccag gtgcagcaat       60

gggttccccg agcgggatcc gccgcggccc gggcccagca ggccggcgga gaagcccccg      120

cggcccgagg ccaagagcgc gcagcccgcg gacggctgga agggcgagcg gccccgcagc      180

gaggaggata acgagctgaa cctccctaac ctggcagccg cctactcgtc catcctgagc      240

tcgctgggcg agaaccccca gcggcaaggg ctgctcaaga cgccctggag ggcggcctcg      300

gccatgcagt tcttcaccaa gggctaccag gagaccatct cagatgtcct aaacgatgct      360

atatttgatg aagatcatga tgagatggtg attgtgaagg acatagacat gttttccatg      420

tgtgagcatc acttggttcc atttgttgga aaggtccata ttggttatct tcctaacaag      480

caagtccttg gcctcagcaa acttgcgagg attgtagaaa tctatagtag aagactacaa      540

gttcaggagc gccttacaaa acaaattgct gtagcaatca cggaagcctt gcggcctgct      600

ggagtcgggg tagtggttga agcaacacac atgtgtatgg taatgcgagg tgtacagaaa      660

atgaacagca aaactgtgac cagcacaatg ttgggtgtgt tccgggagga tccaaagact      720

cgggaagagt tcctgactct cattagga                                         748


<210>  19
<211>  155
<212>  DNA
<213>  Simian virus 40


<220>
<221>  misc_feature
<222>  (1)..(155)
<223>  early poly-adenylation sequence

<400>  19
ttcgagcaac ttgtttattg cagcttataa tggttacaaa taaagcaata gcatcacaaa       60

tttcacaaat aaagcatttt tttcactgca ttctagttgt ggtttgtcca aactcatcaa      120

tgtatcttat catgtctgga tcgtctagca tcgaa                                 155


<210>  20
<211>  192
<212>  DNA
<213>  Simian virus 40


<220>
<221>  misc_feature
<222>  (1)..(192)
<223>  late poly-adenylation sequence

<400>  20
cagacatgat aagatacatt gatgagtttg gacaaaccac aactagaatg cagtgaaaaa       60

aatgctttat ttgtgaaatt tgtgatgcta ttgctttatt tgtaaccatt ataagctgca      120

ataaacaagt taacaacaac aattgcattc attttatgtt tcaggttcag ggggaggtgt      180

gggaggtttt tt                                                          192


<210>  21
<211>  1490
<212>  DNA
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (1)..(1490)
<223>  Tyrosine hydroxylase (TH), transcript variant 2

<400>  21
atgcccaccc ccgacgccac cacgccacag gccaagggct tccgcagggc cgtgtctgag       60

ctggacgcca agcaggcaga ggccatcatg tccccgcggt tcattgggcg caggcagagc      120

ctcatcgagg acgcccgcaa ggagcgggag gcggcggtgg cagcagcggc cgctgcagtc      180

ccctcggagc ccggggaccc cctggaggct gtggcctttg aggagaagga ggggaaggcc      240

gtgctaaacc tgctcttctc cccgagggcc accaagccct cggcgctgtc ccgagctgtg      300

aaggtgtttg agacgtttga agccaaaatc caccatctag agacccggcc cgcccagagg      360

ccgcgagctg ggggccccca cctggagtac ttcgtgcgcc tcgaggtgcg ccgaggggac      420

ctggccgccc tgctcagtgg tgtgcgccag gtgtcagagg acgtgcgcag ccccgcgggg      480

cccaaggtcc cctggttccc aagaaaagtg tcagagctgg acaagtgtca tcacctggtc      540

accaagttcg accctgacct ggacttggac cacccgggct tctcggacca ggtgtaccgc      600

cagcgcagga agctgattgc tgagatcgcc ttccagtaca ggcacggcga cccgattccc      660

cgtgtggagt acaccgccga ggagattgcc acctggaagg aggtctacac cacgctgaag      720

ggcctctacg ccacgcacgc ctgcggggag cacctggagg cctttgcttt gctggagcgc      780

ttcagcggct accgggaaga caatatcccc cagctggagg acgtctcccg cttcctgaag      840

gagcgcacgg gcttccagct gcggcctgtg gccggcctgc tgtccgcccg ggacttcctg      900

gccagcctgg ccttccgcgt gttccagtgc acccagtata tccgccacgc gtcctcgccc      960

atgcactccc ctgagccgga ctgctgccac gagctgctgg ggcacgtgcc catgctggcc     1020

gaccgcacct tcgcgcagtt ctcgcaggac attggcctgg cgtccctggg ggcctcggat     1080

gaggaaattg agaagctgtc cacgctgtac tggttcacgg tggagttcgg gctgtgtaag     1140

cagaacgggg aggtgaaggc ctatggtgcc gggctgctgt cctcctacgg ggagctcctg     1200

cactgcctgt ctgaggagcc tgagattcgg gccttcgacc ctgaggctgc ggccgtgcag     1260

ccctaccaag accagacgta ccagtcagtc tacttcgtgt ctgagagctt cagtgacgcc     1320

aaggacaagc tcaggagcta tgcctcacgc atccagcgcc ccttctccgt gaagttcgac     1380

ccgtacacgc tggccatcga cgtgctggac agcccccagg ccgtgcggcg ctccctggag     1440

ggtgtccagg atgagctgga cacccttgcc catgcgctga gtgccattgg                1490


<210>  22
<211>  610
<212>  DNA
<213>  Woodchuck hepatitis B virus


<220>
<221>  misc_feature
<222>  (1)..(610)
<223>  Woodchuck hepatitis B virus (WHV8) post-transcriptional 
       regulatory element sequence

<400>  22
cgtcgacaat caacctctgg attacaaaat ttgtgaaaga ttgactggta ttcttaacta       60

tgttgctcct tttacgctat gtggatacgc tgctttaatg cctttgtatc atgctattgc      120

ttcccgtatg gctttcattt tctcctcctt gtataaatcc tggttgctgt ctctttatga      180

ggagttgtgg cccgttgtca ggcaacgtgg cgtggtgtgc actgtgtttg ctgacgcaac      240

ccccactggt tggggcattg ccaccacctg tcagctcctt tccgggactt tcgctttccc      300

cctccctatt gccacggcgg aactcatcgc cgcctgcctt gcccgctgct ggacaggggc      360

tcggctgttg ggcactgaca attccgtggt gttgtcgggg aagctgacgt cctttccatg      420

gctgctcgcc tgtgttgcca cctggattct gcgcgggacg tccttctgct acgtcccttc      480

ggccctcaat ccagcggacc ttccttcccg cggcctgctg ccggctctgc ggcctcttcc      540

gcgtcttcgc cttcgccctc agacgagtcg gatctccctt tgggccgcct ccccgcctgg      600

aattcgagct                                                             610


