                         SEQUENCE LISTING

<110>  University of East Anglia
 
<120>  Compounds and their uses in protein binding assays

<130>  P113916PC00

<150>  GB 0919070.3
<151>  2009-10-30

<160>  33    

<170>  PatentIn version 3.3

<210>  1
<211>  354
<212>  PRT
<213>  Homo sapiens

<400>  1

Met Ala Glu Val Leu Arg Thr Leu Ala Gly Lys Pro Lys Cys His Ala 
1               5                   10                  15      


Leu Arg Pro Met Ile Leu Phe Leu Ile Met Leu Val Leu Val Leu Phe 
            20                  25                  30          


Gly Tyr Gly Val Leu Ser Pro Arg Ser Leu Met Pro Gly Ser Leu Glu 
        35                  40                  45              


Arg Gly Phe Cys Met Ala Val Arg Glu Pro Asp His Leu Gln Arg Val 
    50                  55                  60                  


Ser Leu Pro Arg Met Val Tyr Pro Gln Pro Lys Val Leu Thr Pro Cys 
65                  70                  75                  80  


Arg Lys Asp Val Leu Val Val Thr Pro Trp Leu Ala Pro Ile Val Trp 
                85                  90                  95      


Glu Gly Thr Phe Asn Ile Asp Ile Leu Asn Glu Gln Phe Arg Leu Gln 
            100                 105                 110         


Asn Thr Thr Ile Gly Leu Thr Val Phe Ala Ile Lys Lys Tyr Val Ala 
        115                 120                 125             


Phe Leu Lys Leu Phe Leu Glu Thr Ala Glu Lys His Phe Met Val Gly 
    130                 135                 140                 


His Arg Val His Tyr Tyr Val Phe Thr Asp Gln Pro Ala Ala Val Pro 
145                 150                 155                 160 


Arg Val Thr Leu Gly Thr Gly Arg Gln Leu Ser Val Leu Glu Val Gly 
                165                 170                 175     


Ala Tyr Lys Arg Trp Gln Asp Val Ser Met Arg Arg Met Glu Met Ile 
            180                 185                 190         


Ser Asp Phe Cys Glu Arg Arg Phe Leu Ser Glu Val Asp Tyr Leu Val 
        195                 200                 205             


Cys Val Asp Val Asp Met Glu Phe Arg Asp His Val Gly Val Glu Ile 
    210                 215                 220                 


Leu Thr Pro Leu Phe Gly Thr Leu His Pro Ser Phe Tyr Gly Ser Ser 
225                 230                 235                 240 


Arg Glu Ala Phe Thr Tyr Glu Arg Arg Pro Gln Ser Gln Ala Tyr Ile 
                245                 250                 255     


Pro Lys Asp Glu Gly Asp Phe Tyr Tyr Met Gly Ala Phe Phe Gly Gly 
            260                 265                 270         


Ser Val Gln Glu Val Gln Arg Leu Thr Arg Ala Cys His Gln Ala Met 
        275                 280                 285             


Met Val Asp Gln Ala Asn Gly Ile Glu Ala Val Trp His Asp Glu Ser 
    290                 295                 300                 


His Leu Asn Lys Tyr Leu Leu Arg His Lys Pro Thr Lys Val Leu Ser 
305                 310                 315                 320 


Pro Glu Tyr Leu Trp Asp Gln Gln Leu Leu Gly Trp Pro Ala Val Leu 
                325                 330                 335     


Arg Lys Leu Arg Phe Thr Ala Val Pro Lys Asn His Gln Ala Val Arg 
            340                 345                 350         


Asn Pro 
        


<210>  2
<211>  354
<212>  PRT
<213>  Homo sapiens

<400>  2

Met Ala Glu Val Leu Arg Thr Leu Ala Gly Lys Pro Lys Cys His Ala 
1               5                   10                  15      


Leu Arg Pro Met Ile Leu Phe Leu Ile Met Leu Val Leu Val Leu Phe 
            20                  25                  30          


Gly Tyr Gly Val Leu Ser Pro Arg Ser Leu Met Pro Gly Ser Leu Glu 
        35                  40                  45              


Arg Gly Phe Cys Met Ala Val Arg Glu Pro Asp His Leu Gln Arg Val 
    50                  55                  60                  


Ser Leu Pro Arg Met Val Tyr Pro Gln Pro Lys Val Leu Thr Pro Cys 
65                  70                  75                  80  


Arg Lys Asp Val Leu Val Val Thr Pro Trp Leu Ala Pro Ile Val Trp 
                85                  90                  95      


Glu Gly Thr Phe Asn Ile Asp Ile Leu Asn Glu Gln Phe Arg Leu Gln 
            100                 105                 110         


Asn Thr Thr Ile Gly Leu Thr Val Phe Ala Ile Lys Lys Tyr Val Ala 
        115                 120                 125             


Phe Leu Lys Leu Phe Leu Glu Thr Ala Glu Lys His Phe Met Val Gly 
    130                 135                 140                 


His Arg Val His Tyr Tyr Val Phe Thr Asp Gln Pro Ala Ala Val Pro 
145                 150                 155                 160 


Arg Val Thr Leu Gly Thr Gly Arg Gln Leu Ser Val Leu Glu Val Arg 
                165                 170                 175     


Ala Tyr Lys Arg Trp Gln Asp Val Ser Met Arg Arg Met Glu Met Ile 
            180                 185                 190         


Ser Asp Phe Cys Glu Arg Arg Phe Leu Ser Glu Val Asp Tyr Leu Val 
        195                 200                 205             


Cys Val Asp Val Asp Met Glu Phe Arg Asp His Val Gly Val Glu Ile 
    210                 215                 220                 


Leu Thr Pro Leu Phe Gly Thr Leu His Pro Gly Phe Tyr Gly Ser Ser 
225                 230                 235                 240 


Arg Glu Ala Phe Thr Tyr Glu Arg Arg Pro Gln Ser Gln Ala Tyr Ile 
                245                 250                 255     


Pro Lys Asp Glu Gly Asp Phe Tyr Tyr Leu Gly Gly Phe Phe Gly Gly 
            260                 265                 270         


Ser Val Gln Glu Val Gln Arg Leu Thr Arg Ala Cys His Gln Ala Met 
        275                 280                 285             


Met Val Asp Gln Ala Asn Gly Ile Glu Ala Val Trp His Asp Glu Ser 
    290                 295                 300                 


His Leu Asn Lys Tyr Leu Leu Arg His Lys Pro Thr Lys Val Leu Ser 
305                 310                 315                 320 


Pro Glu Tyr Leu Trp Asp Gln Gln Leu Leu Gly Trp Pro Ala Val Leu 
                325                 330                 335     


Arg Lys Leu Arg Phe Thr Ala Val Pro Lys Asn His Gln Ala Val Arg 
            340                 345                 350         


Asn Pro 
        


<210>  3
<211>  354
<212>  PRT
<213>  Artificial

<220>
<223>  ABBB

<400>  3

Met Ala Glu Val Leu Arg Thr Leu Ala Gly Lys Pro Lys Cys His Ala 
1               5                   10                  15      


Leu Arg Pro Met Ile Leu Phe Leu Ile Met Leu Val Leu Val Leu Phe 
            20                  25                  30          


Gly Tyr Gly Val Leu Ser Pro Arg Ser Leu Met Pro Gly Ser Leu Glu 
        35                  40                  45              


Arg Gly Phe Cys Met Ala Val Arg Glu Pro Asp His Leu Gln Arg Val 
    50                  55                  60                  


Ser Leu Pro Arg Met Val Tyr Pro Gln Pro Lys Val Leu Thr Pro Cys 
65                  70                  75                  80  


Arg Lys Asp Val Leu Val Val Thr Pro Trp Leu Ala Pro Ile Val Trp 
                85                  90                  95      


Glu Gly Thr Phe Asn Ile Asp Ile Leu Asn Glu Gln Phe Arg Leu Gln 
            100                 105                 110         


Asn Thr Thr Ile Gly Leu Thr Val Phe Ala Ile Lys Lys Tyr Val Ala 
        115                 120                 125             


Phe Leu Lys Leu Phe Leu Glu Thr Ala Glu Lys His Phe Met Val Gly 
    130                 135                 140                 


His Arg Val His Tyr Tyr Val Phe Thr Asp Gln Pro Ala Ala Val Pro 
145                 150                 155                 160 


Arg Val Thr Leu Gly Thr Gly Arg Gln Leu Ser Val Leu Glu Val Arg 
                165                 170                 175     


Ala Tyr Lys Arg Trp Gln Asp Val Ser Met Arg Arg Met Glu Met Ile 
            180                 185                 190         


Ser Asp Phe Cys Glu Arg Arg Phe Leu Ser Glu Val Asp Tyr Leu Val 
        195                 200                 205             


Cys Val Asp Val Asp Met Glu Phe Arg Asp His Val Gly Val Glu Ile 
    210                 215                 220                 


Leu Thr Pro Leu Phe Gly Thr Leu His Pro Ser Phe Tyr Gly Ser Ser 
225                 230                 235                 240 


Arg Glu Ala Phe Thr Tyr Glu Arg Arg Pro Gln Ser Gln Ala Tyr Ile 
                245                 250                 255     


Pro Lys Asp Glu Gly Asp Phe Tyr Tyr Met Gly Ala Phe Phe Gly Gly 
            260                 265                 270         


Ser Val Gln Glu Val Gln Arg Leu Thr Arg Ala Cys His Gln Ala Met 
        275                 280                 285             


Met Val Asp Gln Ala Asn Gly Ile Glu Ala Val Trp His Asp Glu Ser 
    290                 295                 300                 


His Leu Asn Lys Tyr Leu Leu Arg His Lys Pro Thr Lys Val Leu Ser 
305                 310                 315                 320 


Pro Glu Tyr Leu Trp Asp Gln Gln Leu Leu Gly Trp Pro Ala Val Leu 
                325                 330                 335     


Arg Lys Leu Arg Phe Thr Ala Val Pro Lys Asn His Gln Ala Val Arg 
            340                 345                 350         


Asn Pro 
        


<210>  4
<211>  354
<212>  PRT
<213>  Artificial

<220>
<223>  AABB

<400>  4

Met Ala Glu Val Leu Arg Thr Leu Ala Gly Lys Pro Lys Cys His Ala 
1               5                   10                  15      


Leu Arg Pro Met Ile Leu Phe Leu Ile Met Leu Val Leu Val Leu Phe 
            20                  25                  30          


Gly Tyr Gly Val Leu Ser Pro Arg Ser Leu Met Pro Gly Ser Leu Glu 
        35                  40                  45              


Arg Gly Phe Cys Met Ala Val Arg Glu Pro Asp His Leu Gln Arg Val 
    50                  55                  60                  


Ser Leu Pro Arg Met Val Tyr Pro Gln Pro Lys Val Leu Thr Pro Cys 
65                  70                  75                  80  


Arg Lys Asp Val Leu Val Val Thr Pro Trp Leu Ala Pro Ile Val Trp 
                85                  90                  95      


Glu Gly Thr Phe Asn Ile Asp Ile Leu Asn Glu Gln Phe Arg Leu Gln 
            100                 105                 110         


Asn Thr Thr Ile Gly Leu Thr Val Phe Ala Ile Lys Lys Tyr Val Ala 
        115                 120                 125             


Phe Leu Lys Leu Phe Leu Glu Thr Ala Glu Lys His Phe Met Val Gly 
    130                 135                 140                 


His Arg Val His Tyr Tyr Val Phe Thr Asp Gln Pro Ala Ala Val Pro 
145                 150                 155                 160 


Arg Val Thr Leu Gly Thr Gly Arg Gln Leu Ser Val Leu Glu Val Arg 
                165                 170                 175     


Ala Tyr Lys Arg Trp Gln Asp Val Ser Met Arg Arg Met Glu Met Ile 
            180                 185                 190         


Ser Asp Phe Cys Glu Arg Arg Phe Leu Ser Glu Val Asp Tyr Leu Val 
        195                 200                 205             


Cys Val Asp Val Asp Met Glu Phe Arg Asp His Val Gly Val Glu Ile 
    210                 215                 220                 


Leu Thr Pro Leu Phe Gly Thr Leu His Pro Gly Phe Tyr Gly Ser Ser 
225                 230                 235                 240 


Arg Glu Ala Phe Thr Tyr Glu Arg Arg Pro Gln Ser Gln Ala Tyr Ile 
                245                 250                 255     


Pro Lys Asp Glu Gly Asp Phe Tyr Tyr Met Gly Ala Phe Phe Gly Gly 
            260                 265                 270         


Ser Val Gln Glu Val Gln Arg Leu Thr Arg Ala Cys His Gln Ala Met 
        275                 280                 285             


Met Val Asp Gln Ala Asn Gly Ile Glu Ala Val Trp His Asp Glu Ser 
    290                 295                 300                 


His Leu Asn Lys Tyr Leu Leu Arg His Lys Pro Thr Lys Val Leu Ser 
305                 310                 315                 320 


Pro Glu Tyr Leu Trp Asp Gln Gln Leu Leu Gly Trp Pro Ala Val Leu 
                325                 330                 335     


Arg Lys Leu Arg Phe Thr Ala Val Pro Lys Asn His Gln Ala Val Arg 
            340                 345                 350         


Asn Pro 
        


<210>  5
<211>  354
<212>  PRT
<213>  Artificial

<220>
<223>  AAGlyB

<400>  5

Met Ala Glu Val Leu Arg Thr Leu Ala Gly Lys Pro Lys Cys His Ala 
1               5                   10                  15      


Leu Arg Pro Met Ile Leu Phe Leu Ile Met Leu Val Leu Val Leu Phe 
            20                  25                  30          


Gly Tyr Gly Val Leu Ser Pro Arg Ser Leu Met Pro Gly Ser Leu Glu 
        35                  40                  45              


Arg Gly Phe Cys Met Ala Val Arg Glu Pro Asp His Leu Gln Arg Val 
    50                  55                  60                  


Ser Leu Pro Arg Met Val Tyr Pro Gln Pro Lys Val Leu Thr Pro Cys 
65                  70                  75                  80  


Arg Lys Asp Val Leu Val Val Thr Pro Trp Leu Ala Pro Ile Val Trp 
                85                  90                  95      


Glu Gly Thr Phe Asn Ile Asp Ile Leu Asn Glu Gln Phe Arg Leu Gln 
            100                 105                 110         


Asn Thr Thr Ile Gly Leu Thr Val Phe Ala Ile Lys Lys Tyr Val Ala 
        115                 120                 125             


Phe Leu Lys Leu Phe Leu Glu Thr Ala Glu Lys His Phe Met Val Gly 
    130                 135                 140                 


His Arg Val His Tyr Tyr Val Phe Thr Asp Gln Pro Ala Ala Val Pro 
145                 150                 155                 160 


Arg Val Thr Leu Gly Thr Gly Arg Gln Leu Ser Val Leu Glu Val Arg 
                165                 170                 175     


Ala Tyr Lys Arg Trp Gln Asp Val Ser Met Arg Arg Met Glu Met Ile 
            180                 185                 190         


Ser Asp Phe Cys Glu Arg Arg Phe Leu Ser Glu Val Asp Tyr Leu Val 
        195                 200                 205             


Cys Val Asp Val Asp Met Glu Phe Arg Asp His Val Gly Val Glu Ile 
    210                 215                 220                 


Leu Thr Pro Leu Phe Gly Thr Leu His Pro Gly Phe Tyr Gly Ser Ser 
225                 230                 235                 240 


Arg Glu Ala Phe Thr Tyr Glu Arg Arg Pro Gln Ser Gln Ala Tyr Ile 
                245                 250                 255     


Pro Lys Asp Glu Gly Asp Phe Tyr Tyr Gly Gly Ala Phe Phe Gly Gly 
            260                 265                 270         


Ser Val Gln Glu Val Gln Arg Leu Thr Arg Ala Cys His Gln Ala Met 
        275                 280                 285             


Met Val Asp Gln Ala Asn Gly Ile Glu Ala Val Trp His Asp Glu Ser 
    290                 295                 300                 


His Leu Asn Lys Tyr Leu Leu Arg His Lys Pro Thr Lys Val Leu Ser 
305                 310                 315                 320 


Pro Glu Tyr Leu Trp Asp Gln Gln Leu Leu Gly Trp Pro Ala Val Leu 
                325                 330                 335     


Arg Lys Leu Arg Phe Thr Ala Val Pro Lys Asn His Gln Ala Val Arg 
            340                 345                 350         


Asn Pro 
        


<210>  6
<211>  354
<212>  PRT
<213>  Artificial

<220>
<223>  GTB - M214T

<400>  6

Met Ala Glu Val Leu Arg Thr Leu Ala Gly Lys Pro Lys Cys His Ala 
1               5                   10                  15      


Leu Arg Pro Met Ile Leu Phe Leu Ile Met Leu Val Leu Val Leu Phe 
            20                  25                  30          


Gly Tyr Gly Val Leu Ser Pro Arg Ser Leu Met Pro Gly Ser Leu Glu 
        35                  40                  45              


Arg Gly Phe Cys Met Ala Val Arg Glu Pro Asp His Leu Gln Arg Val 
    50                  55                  60                  


Ser Leu Pro Arg Met Val Tyr Pro Gln Pro Lys Val Leu Thr Pro Cys 
65                  70                  75                  80  


Arg Lys Asp Val Leu Val Val Thr Pro Trp Leu Ala Pro Ile Val Trp 
                85                  90                  95      


Glu Gly Thr Phe Asn Ile Asp Ile Leu Asn Glu Gln Phe Arg Leu Gln 
            100                 105                 110         


Asn Thr Thr Ile Gly Leu Thr Val Phe Ala Ile Lys Lys Tyr Val Ala 
        115                 120                 125             


Phe Leu Lys Leu Phe Leu Glu Thr Ala Glu Lys His Phe Met Val Gly 
    130                 135                 140                 


His Arg Val His Tyr Tyr Val Phe Thr Asp Gln Pro Ala Ala Val Pro 
145                 150                 155                 160 


Arg Val Thr Leu Gly Thr Gly Arg Gln Leu Ser Val Leu Glu Val Gly 
                165                 170                 175     


Ala Tyr Lys Arg Trp Gln Asp Val Ser Met Arg Arg Met Glu Met Ile 
            180                 185                 190         


Ser Asp Phe Cys Glu Arg Arg Phe Leu Ser Glu Val Asp Tyr Leu Val 
        195                 200                 205             


Cys Val Asp Val Asp Thr Glu Phe Arg Asp His Val Gly Val Glu Ile 
    210                 215                 220                 


Leu Thr Pro Leu Phe Gly Thr Leu His Pro Ser Phe Tyr Gly Ser Ser 
225                 230                 235                 240 


Arg Glu Ala Phe Thr Tyr Glu Arg Arg Pro Gln Ser Gln Ala Tyr Ile 
                245                 250                 255     


Pro Lys Asp Glu Gly Asp Phe Tyr Tyr Met Gly Ala Phe Phe Gly Gly 
            260                 265                 270         


Ser Val Gln Glu Val Gln Arg Leu Thr Arg Ala Cys His Gln Ala Met 
        275                 280                 285             


Met Val Asp Gln Ala Asn Gly Ile Glu Ala Val Trp His Asp Glu Ser 
    290                 295                 300                 


His Leu Asn Lys Tyr Leu Leu Arg His Lys Pro Thr Lys Val Leu Ser 
305                 310                 315                 320 


Pro Glu Tyr Leu Trp Asp Gln Gln Leu Leu Gly Trp Pro Ala Val Leu 
                325                 330                 335     


Arg Lys Leu Arg Phe Thr Ala Val Pro Lys Asn His Gln Ala Val Arg 
            340                 345                 350         


Asn Pro 
        


<210>  7
<211>  354
<212>  PRT
<213>  Artificial

<220>
<223>  GTB - M214R

<400>  7

Met Ala Glu Val Leu Arg Thr Leu Ala Gly Lys Pro Lys Cys His Ala 
1               5                   10                  15      


Leu Arg Pro Met Ile Leu Phe Leu Ile Met Leu Val Leu Val Leu Phe 
            20                  25                  30          


Gly Tyr Gly Val Leu Ser Pro Arg Ser Leu Met Pro Gly Ser Leu Glu 
        35                  40                  45              


Arg Gly Phe Cys Met Ala Val Arg Glu Pro Asp His Leu Gln Arg Val 
    50                  55                  60                  


Ser Leu Pro Arg Met Val Tyr Pro Gln Pro Lys Val Leu Thr Pro Cys 
65                  70                  75                  80  


Arg Lys Asp Val Leu Val Val Thr Pro Trp Leu Ala Pro Ile Val Trp 
                85                  90                  95      


Glu Gly Thr Phe Asn Ile Asp Ile Leu Asn Glu Gln Phe Arg Leu Gln 
            100                 105                 110         


Asn Thr Thr Ile Gly Leu Thr Val Phe Ala Ile Lys Lys Tyr Val Ala 
        115                 120                 125             


Phe Leu Lys Leu Phe Leu Glu Thr Ala Glu Lys His Phe Met Val Gly 
    130                 135                 140                 


His Arg Val His Tyr Tyr Val Phe Thr Asp Gln Pro Ala Ala Val Pro 
145                 150                 155                 160 


Arg Val Thr Leu Gly Thr Gly Arg Gln Leu Ser Val Leu Glu Val Gly 
                165                 170                 175     


Ala Tyr Lys Arg Trp Gln Asp Val Ser Met Arg Arg Met Glu Met Ile 
            180                 185                 190         


Ser Asp Phe Cys Glu Arg Arg Phe Leu Ser Glu Val Asp Tyr Leu Val 
        195                 200                 205             


Cys Val Asp Val Asp Arg Glu Phe Arg Asp His Val Gly Val Glu Ile 
    210                 215                 220                 


Leu Thr Pro Leu Phe Gly Thr Leu His Pro Ser Phe Tyr Gly Ser Ser 
225                 230                 235                 240 


Arg Glu Ala Phe Thr Tyr Glu Arg Arg Pro Gln Ser Gln Ala Tyr Ile 
                245                 250                 255     


Pro Lys Asp Glu Gly Asp Phe Tyr Tyr Met Gly Ala Phe Phe Gly Gly 
            260                 265                 270         


Ser Val Gln Glu Val Gln Arg Leu Thr Arg Ala Cys His Gln Ala Met 
        275                 280                 285             


Met Val Asp Gln Ala Asn Gly Ile Glu Ala Val Trp His Asp Glu Ser 
    290                 295                 300                 


His Leu Asn Lys Tyr Leu Leu Arg His Lys Pro Thr Lys Val Leu Ser 
305                 310                 315                 320 


Pro Glu Tyr Leu Trp Asp Gln Gln Leu Leu Gly Trp Pro Ala Val Leu 
                325                 330                 335     


Arg Lys Leu Arg Phe Thr Ala Val Pro Lys Asn His Gln Ala Val Arg 
            340                 345                 350         


Asn Pro 
        


<210>  8
<211>  354
<212>  PRT
<213>  Artificial

<220>
<223>  GTB - M214V

<400>  8

Met Ala Glu Val Leu Arg Thr Leu Ala Gly Lys Pro Lys Cys His Ala 
1               5                   10                  15      


Leu Arg Pro Met Ile Leu Phe Leu Ile Met Leu Val Leu Val Leu Phe 
            20                  25                  30          


Gly Tyr Gly Val Leu Ser Pro Arg Ser Leu Met Pro Gly Ser Leu Glu 
        35                  40                  45              


Arg Gly Phe Cys Met Ala Val Arg Glu Pro Asp His Leu Gln Arg Val 
    50                  55                  60                  


Ser Leu Pro Arg Met Val Tyr Pro Gln Pro Lys Val Leu Thr Pro Cys 
65                  70                  75                  80  


Arg Lys Asp Val Leu Val Val Thr Pro Trp Leu Ala Pro Ile Val Trp 
                85                  90                  95      


Glu Gly Thr Phe Asn Ile Asp Ile Leu Asn Glu Gln Phe Arg Leu Gln 
            100                 105                 110         


Asn Thr Thr Ile Gly Leu Thr Val Phe Ala Ile Lys Lys Tyr Val Ala 
        115                 120                 125             


Phe Leu Lys Leu Phe Leu Glu Thr Ala Glu Lys His Phe Met Val Gly 
    130                 135                 140                 


His Arg Val His Tyr Tyr Val Phe Thr Asp Gln Pro Ala Ala Val Pro 
145                 150                 155                 160 


Arg Val Thr Leu Gly Thr Gly Arg Gln Leu Ser Val Leu Glu Val Gly 
                165                 170                 175     


Ala Tyr Lys Arg Trp Gln Asp Val Ser Met Arg Arg Met Glu Met Ile 
            180                 185                 190         


Ser Asp Phe Cys Glu Arg Arg Phe Leu Ser Glu Val Asp Tyr Leu Val 
        195                 200                 205             


Cys Val Asp Val Asp Val Glu Phe Arg Asp His Val Gly Val Glu Ile 
    210                 215                 220                 


Leu Thr Pro Leu Phe Gly Thr Leu His Pro Ser Phe Tyr Gly Ser Ser 
225                 230                 235                 240 


Arg Glu Ala Phe Thr Tyr Glu Arg Arg Pro Gln Ser Gln Ala Tyr Ile 
                245                 250                 255     


Pro Lys Asp Glu Gly Asp Phe Tyr Tyr Met Gly Ala Phe Phe Gly Gly 
            260                 265                 270         


Ser Val Gln Glu Val Gln Arg Leu Thr Arg Ala Cys His Gln Ala Met 
        275                 280                 285             


Met Val Asp Gln Ala Asn Gly Ile Glu Ala Val Trp His Asp Glu Ser 
    290                 295                 300                 


His Leu Asn Lys Tyr Leu Leu Arg His Lys Pro Thr Lys Val Leu Ser 
305                 310                 315                 320 


Pro Glu Tyr Leu Trp Asp Gln Gln Leu Leu Gly Trp Pro Ala Val Leu 
                325                 330                 335     


Arg Lys Leu Arg Phe Thr Ala Val Pro Lys Asn His Gln Ala Val Arg 
            340                 345                 350         


Asn Pro 
        


<210>  9
<211>  368
<212>  PRT
<213>  Bos taurus

<400>  9

Met Asn Val Lys Gly Lys Val Ile Leu Ser Met Leu Val Val Ser Thr 
1               5                   10                  15      


Val Ile Val Val Phe Trp Glu Tyr Ile His Ser Pro Glu Gly Ser Leu 
            20                  25                  30          


Phe Trp Ile Asn Pro Ser Arg Asn Pro Glu Val Gly Gly Ser Ser Ile 
        35                  40                  45              


Gln Lys Gly Trp Trp Leu Pro Arg Trp Phe Asn Asn Gly Tyr His Glu 
    50                  55                  60                  


Glu Asp Gly Asp Ile Asn Glu Glu Lys Glu Gln Arg Asn Glu Asp Glu 
65                  70                  75                  80  


Ser Lys Leu Lys Leu Ser Asp Trp Phe Asn Pro Phe Lys Arg Pro Glu 
                85                  90                  95      


Val Val Thr Met Thr Lys Trp Lys Ala Pro Val Val Trp Glu Gly Thr 
            100                 105                 110         


Tyr Asn Arg Ala Val Leu Asp Asn Tyr Tyr Ala Lys Gln Lys Ile Thr 
        115                 120                 125             


Val Gly Leu Thr Val Phe Ala Val Gly Arg Tyr Ile Glu His Tyr Leu 
    130                 135                 140                 


Glu Glu Phe Leu Thr Ser Ala Asn Lys His Phe Met Val Gly His Pro 
145                 150                 155                 160 


Val Ile Phe Tyr Ile Met Val Asp Asp Val Ser Arg Met Pro Leu Ile 
                165                 170                 175     


Glu Leu Gly Pro Leu Arg Ser Phe Lys Val Phe Lys Ile Lys Pro Glu 
            180                 185                 190         


Lys Arg Trp Gln Asp Ile Ser Met Met Arg Met Lys Thr Ile Gly Glu 
        195                 200                 205             


His Ile Val Ala His Ile Gln His Glu Val Asp Phe Leu Phe Cys Met 
    210                 215                 220                 


Asp Val Asp Gln Val Phe Gln Asp Lys Phe Gly Val Glu Thr Leu Gly 
225                 230                 235                 240 


Glu Ser Val Ala Gln Leu Gln Ala Trp Trp Tyr Lys Ala Asp Pro Asn 
                245                 250                 255     


Asp Phe Thr Tyr Glu Arg Arg Lys Glu Ser Ala Ala Tyr Ile Pro Phe 
            260                 265                 270         


Gly Glu Gly Asp Phe Tyr Tyr His Ala Ala Ile Phe Gly Gly Thr Pro 
        275                 280                 285             


Thr Gln Val Leu Asn Ile Thr Gln Glu Cys Phe Lys Gly Ile Leu Lys 
    290                 295                 300                 


Asp Lys Lys Asn Asp Ile Glu Ala Gln Trp His Asp Glu Ser His Leu 
305                 310                 315                 320 


Asn Lys Tyr Phe Leu Leu Asn Lys Pro Thr Lys Ile Leu Ser Pro Glu 
                325                 330                 335     


Tyr Cys Trp Asp Tyr His Ile Gly Leu Pro Ala Asp Ile Lys Leu Val 
            340                 345                 350         


Lys Met Ser Trp Gln Thr Lys Glu Tyr Asn Val Val Arg Asn Asn Val 
        355                 360                 365             


<210>  10
<211>  311
<212>  PRT
<213>  Neisseria meningitidis

<400>  10

Met Asp Ile Val Phe Ala Ala Asp Asp Asn Tyr Ala Ala Tyr Leu Cys 
1               5                   10                  15      


Val Ala Ala Lys Ser Val Glu Ala Ala His Pro Asp Thr Glu Ile Arg 
            20                  25                  30          


Phe His Val Leu Asp Ala Gly Ile Ser Glu Ala Asn Arg Ala Ala Val 
        35                  40                  45              


Ala Ala Asn Leu Arg Gly Gly Gly Gly Asn Ile Arg Phe Ile Asp Val 
    50                  55                  60                  


Asn Pro Glu Asp Phe Ala Gly Phe Pro Leu Asn Ile Arg His Ile Ser 
65                  70                  75                  80  


Ile Thr Thr Tyr Ala Arg Leu Lys Leu Gly Glu Tyr Ile Ala Asp Cys 
                85                  90                  95      


Asp Lys Val Leu Tyr Leu Asp Ile Asp Val Leu Val Arg Asp Ser Leu 
            100                 105                 110         


Thr Pro Leu Trp Asp Thr Asp Leu Gly Asp Asn Trp Leu Gly Ala Cys 
        115                 120                 125             


Ile Asp Leu Phe Val Glu Arg Gln Glu Gly Tyr Lys Gln Lys Ile Gly 
    130                 135                 140                 


Met Ala Asp Gly Glu Tyr Tyr Phe Asn Ala Gly Val Leu Leu Ile Asn 
145                 150                 155                 160 


Leu Lys Lys Trp Arg Arg His Asp Ile Phe Lys Met Ser Cys Glu Trp 
                165                 170                 175     


Val Glu Gln Tyr Lys Asp Val Met Gln Tyr Gln Asp Gln Asp Ile Leu 
            180                 185                 190         


Asn Gly Leu Phe Lys Gly Gly Val Cys Tyr Ala Asn Ser Arg Phe Asn 
        195                 200                 205             


Phe Met Pro Thr Asn Tyr Ala Phe Met Ala Asn Trp Phe Ala Ser Arg 
    210                 215                 220                 


His Thr Asp Pro Leu Tyr Arg Asp Arg Thr Asn Thr Val Met Pro Val 
225                 230                 235                 240 


Ala Val Ser His Tyr Cys Gly Ser Ala Lys Pro Trp His Arg Asp Cys 
                245                 250                 255     


Thr Ala Trp Gly Ala Glu Arg Phe Thr Glu Leu Gly Gly Ser Leu Thr 
            260                 265                 270         


Thr Val Pro Glu Glu Trp Arg Gly Lys Leu Ala Val Pro His Arg Met 
        275                 280                 285             


Phe Ser Thr Lys Arg Met Leu Gln Arg Trp Arg Arg Lys Leu Ser Ala 
    290                 295                 300                 


Arg Phe Leu Arg Lys Ile Tyr 
305                 310     


<210>  11
<211>  402
<212>  PRT
<213>  Bos taurus

<400>  11

Met Lys Phe Arg Glu Pro Leu Leu Gly Gly Ser Ala Ala Met Pro Gly 
1               5                   10                  15      


Ala Ser Leu Gln Arg Ala Cys Arg Leu Leu Val Ala Val Cys Ala Leu 
            20                  25                  30          


His Leu Gly Val Thr Leu Val Tyr Tyr Leu Ala Gly Arg Asp Leu Arg 
        35                  40                  45              


Arg Leu Pro Gln Leu Val Gly Val His Pro Pro Leu Gln Gly Ser Ser 
    50                  55                  60                  


His Gly Ala Ala Ala Ile Gly Gln Pro Ser Gly Glu Leu Arg Leu Arg 
65                  70                  75                  80  


Gly Val Ala Pro Pro Pro Pro Leu Gln Asn Ser Ser Lys Pro Arg Ser 
                85                  90                  95      


Arg Ala Pro Ser Asn Leu Asp Ala Tyr Ser His Pro Gly Pro Gly Pro 
            100                 105                 110         


Gly Pro Gly Ser Asn Leu Thr Ser Ala Pro Val Pro Ser Thr Thr Thr 
        115                 120                 125             


Arg Ser Leu Thr Ala Cys Pro Glu Glu Ser Pro Leu Leu Val Gly Pro 
    130                 135                 140                 


Met Leu Ile Glu Phe Asn Ile Pro Val Asp Leu Lys Leu Val Glu Gln 
145                 150                 155                 160 


Gln Asn Pro Lys Val Lys Leu Gly Gly Arg Tyr Thr Pro Met Asp Cys 
                165                 170                 175     


Ile Ser Pro His Lys Val Ala Ile Ile Ile Pro Phe Arg Asn Arg Gln 
            180                 185                 190         


Glu His Leu Lys Tyr Trp Leu Tyr Tyr Leu His Pro Ile Leu Gln Arg 
        195                 200                 205             


Gln Gln Leu Asp Tyr Gly Ile Tyr Val Ile Asn Gln Ala Gly Glu Ser 
    210                 215                 220                 


Met Phe Asn Arg Ala Lys Leu Leu Asn Val Gly Phe Lys Glu Ala Leu 
225                 230                 235                 240 


Lys Asp Tyr Asp Tyr Asn Cys Phe Val Phe Ser Asp Val Asp Leu Ile 
                245                 250                 255     


Pro Met Asn Asp His Asn Thr Tyr Arg Cys Phe Ser Gln Pro Arg His 
            260                 265                 270         


Ile Ser Val Ala Met Asp Lys Phe Gly Phe Ser Leu Pro Tyr Val Gln 
        275                 280                 285             


Tyr Phe Gly Gly Val Ser Ala Leu Ser Lys Gln Gln Phe Leu Ser Ile 
    290                 295                 300                 


Asn Gly Phe Pro Asn Asn Tyr Trp Gly Trp Gly Gly Glu Asp Asp Asp 
305                 310                 315                 320 


Ile Tyr Asn Arg Leu Ala Phe Arg Gly Met Ser Val Ser Arg Pro Asn 
                325                 330                 335     


Ala Val Ile Gly Lys Cys Arg Met Ile Arg His Ser Arg Asp Lys Lys 
            340                 345                 350         


Asn Glu Pro Asn Pro Gln Arg Phe Asp Arg Ile Ala His Thr Lys Glu 
        355                 360                 365             


Thr Met Leu Ser Asp Gly Leu Asn Ser Leu Thr Tyr Met Val Leu Glu 
    370                 375                 380                 


Val Gln Arg Tyr Pro Leu Tyr Thr Lys Ile Thr Val Asp Ile Gly Thr 
385                 390                 395                 400 


Pro Ser 
        


<210>  12
<211>  398
<212>  PRT
<213>  Homo sapiens

<400>  12

Met Arg Leu Arg Glu Pro Leu Leu Ser Gly Ser Ala Ala Met Pro Gly 
1               5                   10                  15      


Ala Ser Leu Gln Arg Ala Cys Arg Leu Leu Val Ala Val Cys Ala Leu 
            20                  25                  30          


His Leu Gly Val Thr Leu Val Tyr Tyr Leu Ala Gly Arg Asp Leu Ser 
        35                  40                  45              


Arg Leu Pro Gln Leu Val Gly Val Ser Thr Pro Leu Gln Gly Gly Ser 
    50                  55                  60                  


Asn Ser Ala Ala Ala Ile Gly Gln Ser Ser Gly Glu Leu Arg Thr Gly 
65                  70                  75                  80  


Gly Ala Arg Pro Pro Pro Pro Leu Gly Ala Ser Ser Gln Pro Arg Pro 
                85                  90                  95      


Gly Gly Asp Ser Ser Pro Val Val Asp Ser Gly Pro Gly Pro Ala Ser 
            100                 105                 110         


Asn Leu Thr Ser Val Pro Val Pro His Thr Thr Ala Leu Ser Leu Pro 
        115                 120                 125             


Ala Cys Pro Glu Glu Ser Pro Leu Leu Val Gly Pro Met Leu Ile Glu 
    130                 135                 140                 


Phe Asn Met Pro Val Asp Leu Glu Leu Val Ala Lys Gln Asn Pro Asn 
145                 150                 155                 160 


Val Lys Met Gly Gly Arg Tyr Ala Pro Arg Asp Cys Val Ser Pro His 
                165                 170                 175     


Lys Val Ala Ile Ile Ile Pro Phe Arg Asn Arg Gln Glu His Leu Lys 
            180                 185                 190         


Tyr Trp Leu Tyr Tyr Leu His Pro Val Leu Gln Arg Gln Gln Leu Asp 
        195                 200                 205             


Tyr Gly Ile Tyr Val Ile Asn Gln Ala Gly Asp Thr Ile Phe Asn Arg 
    210                 215                 220                 


Ala Lys Leu Leu Asn Val Gly Phe Gln Glu Ala Leu Lys Asp Tyr Asp 
225                 230                 235                 240 


Tyr Thr Cys Phe Val Phe Ser Asp Val Asp Leu Ile Pro Met Asn Asp 
                245                 250                 255     


His Asn Ala Tyr Arg Cys Phe Ser Gln Pro Arg His Ile Ser Val Ala 
            260                 265                 270         


Met Asp Lys Phe Gly Phe Ser Leu Pro Tyr Val Gln Tyr Phe Gly Gly 
        275                 280                 285             


Val Ser Ala Leu Ser Lys Gln Gln Phe Leu Thr Ile Asn Gly Phe Pro 
    290                 295                 300                 


Asn Asn Tyr Trp Gly Trp Gly Gly Glu Asp Asp Asp Ile Phe Asn Arg 
305                 310                 315                 320 


Leu Val Phe Arg Gly Met Ser Ile Ser Arg Pro Asn Ala Val Val Gly 
                325                 330                 335     


Arg Cys Arg Met Ile Arg His Ser Arg Asp Lys Lys Asn Glu Pro Asn 
            340                 345                 350         


Pro Gln Arg Phe Asp Arg Ile Ala His Thr Lys Glu Thr Met Leu Ser 
        355                 360                 365             


Asp Gly Leu Asn Ser Leu Thr Tyr Gln Val Leu Asp Val Gln Arg Tyr 
    370                 375                 380                 


Pro Leu Tyr Thr Gln Ile Thr Val Asp Ile Gly Thr Pro Ser 
385                 390                 395             


<210>  13
<211>  273
<212>  PRT
<213>  Helicobacter pylori

<400>  13

Met Arg Val Phe Ala Ile Ser Leu Asn Gln Lys Val Cys Asp Thr Phe 
1               5                   10                  15      


Gly Leu Val Phe Arg Asp Thr Thr Thr Leu Leu Asn Ser Ile Asn Ala 
            20                  25                  30          


Thr His His Gln Ala Gln Ile Phe Asp Ala Ile Tyr Ser Lys Thr Phe 
        35                  40                  45              


Glu Gly Gly Leu His Pro Leu Val Lys Lys His Leu His Pro Tyr Phe 
    50                  55                  60                  


Ile Thr Gln Asn Ile Lys Asp Met Gly Ile Thr Thr Asn Leu Ile Ser 
65                  70                  75                  80  


Glu Val Ser Lys Phe Tyr Tyr Ala Leu Lys Tyr His Ala Lys Phe Met 
                85                  90                  95      


Ser Leu Gly Glu Leu Gly Cys Tyr Ala Ser His Tyr Ser Leu Trp Glu 
            100                 105                 110         


Lys Cys Ile Glu Leu Asn Glu Ala Ile Cys Ile Leu Glu Asp Asp Ile 
        115                 120                 125             


Thr Leu Lys Glu Asp Phe Lys Glu Gly Leu Asp Phe Leu Glu Lys His 
    130                 135                 140                 


Ile Gln Glu Leu Gly Tyr Ile Arg Leu Met His Leu Leu Tyr Asp Ala 
145                 150                 155                 160 


Ser Val Lys Ser Glu Pro Leu Ser His Lys Asn His Glu Ile Gln Glu 
                165                 170                 175     


Arg Val Gly Ile Ile Lys Ala Tyr Ser Glu Gly Val Gly Thr Gln Gly 
            180                 185                 190         


Tyr Val Ile Thr Pro Lys Ile Ala Lys Val Phe Leu Lys Cys Ser Arg 
        195                 200                 205             


Lys Trp Val Val Pro Val Asp Thr Ile Met Asp Ala Thr Phe Ile His 
    210                 215                 220                 


Gly Val Lys Asn Leu Val Leu Gln Pro Phe Val Ile Ala Asp Asp Glu 
225                 230                 235                 240 


Gln Ile Ser Thr Ile Ala Arg Lys Glu Glu Pro Tyr Ser Pro Lys Ile 
                245                 250                 255     


Ala Leu Met Arg Glu Leu His Phe Lys Tyr Leu Lys Tyr Trp Gln Phe 
            260                 265                 270         


Val 
    


<210>  14
<211>  275
<212>  PRT
<213>  Neisseria meningitidis

<400>  14

Met Gln Asn His Val Ile Ser Leu Ala Ser Ala Ala Glu Arg Arg Ala 
1               5                   10                  15      


His Ile Ala Asp Thr Phe Gly Arg His Gly Ile Pro Phe Gln Phe Phe 
            20                  25                  30          


Asp Ala Leu Met Pro Ser Glu Arg Leu Glu Gln Ala Met Ala Glu Leu 
        35                  40                  45              


Val Pro Gly Leu Ser Ala His Pro Tyr Leu Ser Gly Val Glu Lys Ala 
    50                  55                  60                  


Cys Phe Met Ser His Ala Val Leu Trp Lys Gln Ala Leu Asp Glu Gly 
65                  70                  75                  80  


Leu Pro Tyr Ile Thr Val Phe Glu Asp Asp Val Leu Leu Gly Glu Gly 
                85                  90                  95      


Ala Glu Lys Phe Leu Ala Glu Asp Ala Trp Leu Gln Glu Arg Phe Asp 
            100                 105                 110         


Pro Asp Thr Ala Phe Ile Val Arg Leu Glu Thr Met Phe Met His Val 
        115                 120                 125             


Leu Thr Ser Pro Ser Gly Val Ala Asp Tyr Cys Gly Arg Ala Phe Pro 
    130                 135                 140                 


Leu Leu Glu Ser Glu His Trp Gly Thr Ala Gly Tyr Ile Ile Ser Arg 
145                 150                 155                 160 


Lys Ala Met Arg Phe Phe Leu Asp Arg Phe Ala Ala Leu Pro Pro Glu 
                165                 170                 175     


Gly Leu His Pro Val Asp Leu Met Met Phe Ser Asp Phe Phe Asp Arg 
            180                 185                 190         


Glu Gly Met Pro Val Cys Gln Leu Asn Pro Ala Leu Cys Ala Gln Glu 
        195                 200                 205             


Leu His Tyr Ala Lys Phe His Asp Gln Asn Ser Ala Leu Gly Ser Leu 
    210                 215                 220                 


Ile Glu His Asp Arg Leu Leu Asn Arg Lys Gln Gln Arg Arg Asp Ser 
225                 230                 235                 240 


Pro Ala Asn Thr Phe Lys His Arg Leu Ile Arg Ala Leu Thr Lys Ile 
                245                 250                 255     


Ser Arg Glu Arg Glu Lys Arg Arg Gln Arg Arg Glu Gln Phe Ile Val 
            260                 265                 270         


Pro Phe Gln 
        275 


<210>  15
<211>  445
<212>  PRT
<213>  Homo sapiens

<400>  15

Met Leu Lys Lys Gln Ser Ala Gly Leu Val Leu Trp Gly Ala Ile Leu 
1               5                   10                  15      


Phe Val Ala Trp Asn Ala Leu Leu Leu Leu Phe Phe Trp Thr Arg Pro 
            20                  25                  30          


Ala Pro Gly Arg Pro Pro Ser Val Ser Ala Leu Asp Gly Asp Pro Ala 
        35                  40                  45              


Ser Leu Thr Arg Glu Val Ile Arg Leu Ala Gln Asp Ala Glu Val Glu 
    50                  55                  60                  


Leu Glu Arg Gln Arg Gly Leu Leu Gln Gln Ile Gly Asp Ala Leu Ser 
65                  70                  75                  80  


Ser Gln Arg Gly Arg Val Pro Thr Ala Ala Pro Pro Ala Gln Pro Arg 
                85                  90                  95      


Val Pro Val Thr Pro Ala Pro Ala Val Ile Pro Ile Leu Val Ile Ala 
            100                 105                 110         


Cys Asp Arg Ser Thr Val Arg Arg Cys Leu Asp Lys Leu Leu His Tyr 
        115                 120                 125             


Arg Pro Ser Ala Glu Leu Phe Pro Ile Ile Val Ser Gln Asp Cys Gly 
    130                 135                 140                 


His Glu Glu Thr Ala Gln Ala Ile Ala Ser Tyr Gly Ser Ala Val Thr 
145                 150                 155                 160 


His Ile Arg Gln Pro Asp Leu Ser Ser Ile Ala Val Pro Pro Asp His 
                165                 170                 175     


Arg Lys Phe Gln Gly Tyr Tyr Lys Ile Ala Arg His Tyr Arg Trp Ala 
            180                 185                 190         


Leu Gly Gln Val Phe Arg Gln Phe Arg Phe Pro Ala Ala Val Val Val 
        195                 200                 205             


Glu Asp Asp Leu Glu Val Ala Pro Asp Phe Phe Glu Tyr Phe Arg Ala 
    210                 215                 220                 


Thr Tyr Pro Leu Leu Lys Ala Asp Pro Ser Leu Trp Cys Val Ser Ala 
225                 230                 235                 240 


Trp Asn Asp Asn Gly Lys Glu Gln Met Val Asp Ala Ser Arg Pro Glu 
                245                 250                 255     


Leu Leu Tyr Arg Thr Asp Phe Phe Pro Gly Leu Gly Trp Leu Leu Leu 
            260                 265                 270         


Ala Glu Leu Trp Ala Glu Leu Glu Pro Lys Trp Pro Lys Ala Phe Trp 
        275                 280                 285             


Asp Asp Trp Met Arg Arg Pro Glu Gln Arg Gln Gly Arg Ala Cys Ile 
    290                 295                 300                 


Arg Pro Glu Ile Ser Arg Thr Met Thr Phe Gly Arg Lys Gly Val Ser 
305                 310                 315                 320 


His Gly Gln Phe Phe Asp Gln His Leu Lys Phe Ile Lys Leu Asn Gln 
                325                 330                 335     


Gln Phe Val His Phe Thr Gln Leu Asp Leu Ser Tyr Leu Gln Arg Glu 
            340                 345                 350         


Ala Tyr Asp Arg Asp Phe Leu Ala Arg Val Tyr Gly Ala Pro Gln Leu 
        355                 360                 365             


Gln Val Glu Lys Val Arg Thr Asn Asp Arg Lys Glu Leu Gly Glu Val 
    370                 375                 380                 


Arg Val Gln Tyr Thr Gly Arg Asp Ser Phe Lys Ala Phe Ala Lys Ala 
385                 390                 395                 400 


Leu Gly Val Met Asp Asp Leu Lys Ser Gly Val Pro Arg Ala Gly Tyr 
                405                 410                 415     


Arg Gly Ile Val Thr Phe Gln Phe Arg Gly Arg Arg Val His Leu Ala 
            420                 425                 430         


Pro Pro Pro Thr Trp Glu Gly Tyr Asp Pro Ser Trp Asn 
        435                 440                 445 


<210>  16
<211>  741
<212>  PRT
<213>  Homo sapiens

<400>  16

Met Ala Leu Phe Thr Pro Trp Lys Leu Ser Ser Gln Lys Leu Gly Phe 
1               5                   10                  15      


Phe Leu Val Thr Phe Gly Phe Ile Trp Gly Met Met Leu Leu His Phe 
            20                  25                  30          


Thr Ile Gln Gln Arg Thr Gln Pro Glu Ser Ser Ser Met Leu Arg Glu 
        35                  40                  45              


Gln Ile Leu Asp Leu Ser Lys Arg Tyr Ile Lys Ala Leu Ala Glu Glu 
    50                  55                  60                  


Asn Arg Asn Val Val Asp Gly Pro Tyr Ala Gly Val Met Thr Ala Tyr 
65                  70                  75                  80  


Asp Leu Lys Lys Thr Leu Ala Val Leu Leu Asp Asn Ile Leu Gln Arg 
                85                  90                  95      


Ile Gly Lys Leu Glu Ser Lys Val Asp Asn Leu Val Val Asn Gly Thr 
            100                 105                 110         


Gly Thr Asn Ser Thr Asn Ser Thr Thr Ala Val Pro Ser Leu Val Ala 
        115                 120                 125             


Leu Glu Lys Ile Asn Val Ala Asp Ile Ile Asn Gly Ala Gln Glu Lys 
    130                 135                 140                 


Cys Val Leu Pro Pro Met Asp Gly Tyr Pro His Cys Glu Gly Lys Ile 
145                 150                 155                 160 


Lys Trp Met Lys Asp Met Trp Arg Ser Asp Pro Cys Tyr Ala Asp Tyr 
                165                 170                 175     


Gly Val Asp Gly Ser Thr Cys Ser Phe Phe Ile Tyr Leu Ser Glu Val 
            180                 185                 190         


Glu Asn Trp Cys Pro His Leu Pro Trp Arg Ala Lys Asn Pro Tyr Glu 
        195                 200                 205             


Glu Ala Asp His Asn Ser Leu Ala Glu Ile Arg Thr Asp Phe Asn Ile 
    210                 215                 220                 


Leu Tyr Ser Met Met Lys Lys His Glu Glu Phe Arg Trp Met Arg Leu 
225                 230                 235                 240 


Arg Ile Arg Arg Met Ala Asp Ala Trp Ile Gln Ala Ile Lys Ser Leu 
                245                 250                 255     


Ala Glu Lys Gln Asn Leu Glu Lys Arg Lys Arg Lys Lys Val Leu Val 
            260                 265                 270         


His Leu Gly Leu Leu Thr Lys Glu Ser Gly Phe Lys Ile Ala Glu Thr 
        275                 280                 285             


Ala Phe Ser Gly Gly Pro Leu Gly Glu Leu Val Gln Trp Ser Asp Leu 
    290                 295                 300                 


Ile Thr Ser Leu Tyr Leu Leu Gly His Asp Ile Arg Ile Ser Ala Ser 
305                 310                 315                 320 


Leu Ala Glu Leu Lys Glu Ile Met Lys Lys Val Val Gly Asn Arg Ser 
                325                 330                 335     


Gly Cys Pro Thr Val Gly Asp Arg Ile Val Glu Leu Ile Tyr Ile Asp 
            340                 345                 350         


Ile Val Gly Leu Ala Gln Phe Lys Lys Thr Leu Gly Pro Ser Trp Val 
        355                 360                 365             


His Tyr Gln Cys Met Leu Arg Val Leu Asp Ser Phe Gly Thr Glu Pro 
    370                 375                 380                 


Glu Phe Asn His Ala Asn Tyr Ala Gln Ser Lys Gly His Lys Thr Pro 
385                 390                 395                 400 


Trp Gly Lys Trp Asn Leu Asn Pro Gln Gln Phe Tyr Thr Met Phe Pro 
                405                 410                 415     


His Thr Pro Asp Asn Ser Phe Leu Gly Phe Val Val Glu Gln His Leu 
            420                 425                 430         


Asn Ser Ser Asp Ile His His Ile Asn Glu Ile Lys Arg Gln Asn Gln 
        435                 440                 445             


Ser Leu Val Tyr Gly Lys Val Asp Ser Phe Trp Lys Asn Lys Lys Ile 
    450                 455                 460                 


Tyr Leu Asp Ile Ile His Thr Tyr Met Glu Val His Ala Thr Val Tyr 
465                 470                 475                 480 


Gly Ser Ser Thr Lys Asn Ile Pro Ser Tyr Val Lys Asn His Gly Ile 
                485                 490                 495     


Leu Ser Gly Arg Asp Leu Gln Phe Leu Leu Arg Glu Thr Lys Leu Phe 
            500                 505                 510         


Val Gly Leu Gly Phe Pro Tyr Glu Gly Pro Ala Pro Leu Glu Ala Ile 
        515                 520                 525             


Ala Asn Gly Cys Ala Phe Leu Asn Pro Lys Phe Asn Pro Pro Lys Ser 
    530                 535                 540                 


Ser Lys Asn Thr Asp Phe Phe Ile Gly Lys Pro Thr Leu Arg Glu Leu 
545                 550                 555                 560 


Thr Ser Gln His Pro Tyr Ala Glu Val Phe Ile Gly Arg Pro His Val 
                565                 570                 575     


Trp Thr Val Asp Leu Asn Asn Gln Glu Glu Val Glu Asp Ala Val Lys 
            580                 585                 590         


Ala Ile Leu Asn Gln Lys Ile Glu Pro Tyr Met Pro Tyr Glu Phe Thr 
        595                 600                 605             


Cys Glu Gly Met Leu Gln Arg Ile Asn Ala Phe Ile Glu Lys Gln Asp 
    610                 615                 620                 


Phe Cys His Gly Gln Val Met Trp Pro Pro Leu Ser Ala Leu Gln Val 
625                 630                 635                 640 


Lys Leu Ala Glu Pro Gly Gln Ser Cys Lys Gln Val Cys Gln Glu Ser 
                645                 650                 655     


Gln Leu Ile Cys Glu Pro Ser Phe Phe Gln His Leu Asn Lys Asp Lys 
            660                 665                 670         


Asp Met Leu Lys Tyr Lys Val Thr Cys Gln Ser Ser Glu Leu Ala Lys 
        675                 680                 685             


Asp Ile Leu Val Pro Ser Phe Asp Pro Lys Asn Lys His Cys Val Phe 
    690                 695                 700                 


Gln Gly Asp Leu Leu Leu Phe Ser Cys Ala Gly Ala His Pro Arg His 
705                 710                 715                 720 


Gln Arg Val Cys Pro Cys Arg Asp Phe Ile Lys Gly Gln Val Ala Leu 
                725                 730                 735     


Cys Lys Asp Cys Leu 
            740     


<210>  17
<211>  1046
<212>  PRT
<213>  Homo sapiens

<400>  17

Met Ala Ser Ser Val Gly Asn Val Ala Asp Ser Thr Glu Pro Thr Lys 
1               5                   10                  15      


Arg Met Leu Ser Phe Gln Gly Leu Ala Glu Leu Ala His Arg Glu Tyr 
            20                  25                  30          


Gln Ala Gly Asp Phe Glu Ala Ala Glu Arg His Cys Met Gln Leu Trp 
        35                  40                  45              


Arg Gln Glu Pro Asp Asn Thr Gly Val Leu Leu Leu Leu Ser Ser Ile 
    50                  55                  60                  


His Phe Gln Cys Arg Arg Leu Asp Arg Ser Ala His Phe Ser Thr Leu 
65                  70                  75                  80  


Ala Ile Lys Gln Asn Pro Leu Leu Ala Glu Ala Tyr Ser Asn Leu Gly 
                85                  90                  95      


Asn Val Tyr Lys Glu Arg Gly Gln Leu Gln Glu Ala Ile Glu His Tyr 
            100                 105                 110         


Arg His Ala Leu Arg Leu Lys Pro Asp Phe Ile Asp Gly Tyr Ile Asn 
        115                 120                 125             


Leu Ala Ala Ala Leu Val Ala Ala Gly Asp Met Glu Gly Ala Val Gln 
    130                 135                 140                 


Ala Tyr Val Ser Ala Leu Gln Tyr Asn Pro Asp Leu Tyr Cys Val Arg 
145                 150                 155                 160 


Ser Asp Leu Gly Asn Leu Leu Lys Ala Leu Gly Arg Leu Glu Glu Ala 
                165                 170                 175     


Lys Ala Cys Tyr Leu Lys Ala Ile Glu Thr Gln Pro Asn Phe Ala Val 
            180                 185                 190         


Ala Trp Ser Asn Leu Gly Cys Val Phe Asn Ala Gln Gly Glu Ile Trp 
        195                 200                 205             


Leu Ala Ile His His Phe Glu Lys Ala Val Thr Leu Asp Pro Asn Phe 
    210                 215                 220                 


Leu Asp Ala Tyr Ile Asn Leu Gly Asn Val Leu Lys Glu Ala Arg Ile 
225                 230                 235                 240 


Phe Asp Arg Ala Val Ala Ala Tyr Leu Arg Ala Leu Ser Leu Ser Pro 
                245                 250                 255     


Asn His Ala Val Val His Gly Asn Leu Ala Cys Val Tyr Tyr Glu Gln 
            260                 265                 270         


Gly Leu Ile Asp Leu Ala Ile Asp Thr Tyr Arg Arg Ala Ile Glu Leu 
        275                 280                 285             


Gln Pro His Phe Pro Asp Ala Tyr Cys Asn Leu Ala Asn Ala Leu Lys 
    290                 295                 300                 


Glu Lys Gly Ser Val Ala Glu Ala Glu Asp Cys Tyr Asn Thr Ala Leu 
305                 310                 315                 320 


Arg Leu Cys Pro Thr His Ala Asp Ser Leu Asn Asn Leu Ala Asn Ile 
                325                 330                 335     


Lys Arg Glu Gln Gly Asn Ile Glu Glu Ala Val Arg Leu Tyr Arg Lys 
            340                 345                 350         


Ala Leu Glu Val Phe Pro Glu Phe Ala Ala Ala His Ser Asn Leu Ala 
        355                 360                 365             


Ser Val Leu Gln Gln Gln Gly Lys Leu Gln Glu Ala Leu Met His Tyr 
    370                 375                 380                 


Lys Glu Ala Ile Arg Ile Ser Pro Thr Phe Ala Asp Ala Tyr Ser Asn 
385                 390                 395                 400 


Met Gly Asn Thr Leu Lys Glu Met Gln Asp Val Gln Gly Ala Leu Gln 
                405                 410                 415     


Cys Tyr Thr Arg Ala Ile Gln Ile Asn Pro Ala Phe Ala Asp Ala His 
            420                 425                 430         


Ser Asn Leu Ala Ser Ile His Lys Asp Ser Gly Asn Ile Pro Glu Ala 
        435                 440                 445             


Ile Ala Ser Tyr Arg Thr Ala Leu Lys Leu Lys Pro Asp Phe Pro Asp 
    450                 455                 460                 


Ala Tyr Cys Asn Leu Ala His Cys Leu Gln Ile Val Cys Asp Trp Thr 
465                 470                 475                 480 


Asp Tyr Asp Glu Arg Met Lys Lys Leu Val Ser Ile Val Ala Asp Gln 
                485                 490                 495     


Leu Glu Lys Asn Arg Leu Pro Ser Val His Pro His His Ser Met Leu 
            500                 505                 510         


Tyr Pro Leu Ser His Gly Phe Arg Lys Ala Ile Ala Glu Arg His Gly 
        515                 520                 525             


Asn Leu Cys Leu Asp Lys Ile Asn Val Leu His Lys Pro Pro Tyr Glu 
    530                 535                 540                 


His Pro Lys Asp Leu Lys Leu Ser Asp Gly Arg Leu Arg Val Gly Tyr 
545                 550                 555                 560 


Val Ser Ser Asp Phe Gly Asn His Pro Thr Ser His Leu Met Gln Ser 
                565                 570                 575     


Ile Pro Gly Met His Asn Pro Asp Lys Phe Glu Val Phe Cys Tyr Ala 
            580                 585                 590         


Leu Ser Pro Asp Asp Gly Thr Asn Phe Arg Val Lys Val Met Ala Glu 
        595                 600                 605             


Ala Asn His Phe Ile Asp Leu Ser Gln Ile Pro Cys Asn Gly Lys Ala 
    610                 615                 620                 


Ala Asp Arg Ile His Gln Asp Gly Ile His Ile Leu Val Asn Met Asn 
625                 630                 635                 640 


Gly Tyr Thr Lys Gly Ala Arg Asn Glu Leu Phe Ala Leu Arg Pro Ala 
                645                 650                 655     


Pro Ile Gln Ala Met Trp Leu Gly Tyr Pro Gly Thr Ser Gly Ala Leu 
            660                 665                 670         


Phe Met Asp Tyr Ile Ile Thr Asp Gln Glu Thr Ser Pro Ala Glu Val 
        675                 680                 685             


Ala Glu Gln Tyr Ser Glu Lys Leu Ala Tyr Met Pro His Thr Phe Phe 
    690                 695                 700                 


Ile Gly Asp His Ala Asn Met Phe Pro His Leu Lys Lys Lys Ala Val 
705                 710                 715                 720 


Ile Asp Phe Lys Ser Asn Gly His Ile Tyr Asp Asn Arg Ile Val Leu 
                725                 730                 735     


Asn Gly Ile Asp Leu Lys Ala Phe Leu Asp Ser Leu Pro Asp Val Lys 
            740                 745                 750         


Ile Val Lys Met Lys Cys Pro Asp Gly Gly Asp Asn Ala Asp Ser Ser 
        755                 760                 765             


Asn Thr Ala Leu Asn Met Pro Val Ile Pro Met Asn Thr Ile Ala Glu 
    770                 775                 780                 


Ala Val Ile Glu Met Ile Asn Arg Gly Gln Ile Gln Ile Thr Ile Asn 
785                 790                 795                 800 


Gly Phe Ser Ile Ser Asn Gly Leu Ala Thr Thr Gln Ile Asn Asn Lys 
                805                 810                 815     


Ala Ala Thr Gly Glu Glu Val Pro Arg Thr Ile Ile Val Thr Thr Arg 
            820                 825                 830         


Ser Gln Tyr Gly Leu Pro Glu Asp Ala Ile Val Tyr Cys Asn Phe Asn 
        835                 840                 845             


Gln Leu Tyr Lys Ile Asp Pro Ser Thr Leu Gln Met Trp Ala Asn Ile 
    850                 855                 860                 


Leu Lys Arg Val Pro Asn Ser Val Leu Trp Leu Leu Arg Phe Pro Ala 
865                 870                 875                 880 


Val Gly Glu Pro Asn Ile Gln Gln Tyr Ala Gln Asn Met Gly Leu Pro 
                885                 890                 895     


Gln Asn Arg Ile Ile Phe Ser Pro Val Ala Pro Lys Glu Glu His Val 
            900                 905                 910         


Arg Arg Gly Gln Leu Ala Asp Val Cys Leu Asp Thr Pro Leu Cys Asn 
        915                 920                 925             


Gly His Thr Thr Gly Met Asp Val Leu Trp Ala Gly Thr Pro Met Val 
    930                 935                 940                 


Thr Met Pro Gly Glu Thr Leu Ala Ser Arg Val Ala Ala Ser Gln Leu 
945                 950                 955                 960 


Thr Cys Leu Gly Cys Leu Glu Leu Ile Ala Lys Asn Arg Gln Glu Tyr 
                965                 970                 975     


Glu Asp Ile Ala Val Lys Leu Gly Thr Asp Leu Glu Tyr Leu Lys Lys 
            980                 985                 990         


Val Arg Gly Lys Val Trp Lys Gln  Arg Ile Ser Ser Pro  Leu Phe Asn 
        995                 1000                 1005             


Thr Lys  Gln Tyr Thr Met Glu  Leu Glu Arg Leu Tyr  Leu Gln Met 
    1010                 1015                 1020             


Trp Glu  His Tyr Ala Ala Gly  Asn Lys Pro Asp His  Met Ile Lys 
    1025                 1030                 1035             


Pro Val  Glu Val Thr Glu Ser  Ala 
    1040                 1045     


<210>  18
<211>  355
<212>  PRT
<213>  Escherichia coli

<400>  18

Met Ser Gly Gln Gly Lys Arg Leu Met Val Met Ala Gly Gly Thr Gly 
1               5                   10                  15      


Gly His Val Phe Pro Gly Leu Ala Val Ala His His Leu Met Ala Gln 
            20                  25                  30          


Gly Trp Gln Val Arg Trp Leu Gly Thr Ala Asp Arg Met Glu Ala Asp 
        35                  40                  45              


Leu Val Pro Lys His Gly Ile Glu Ile Asp Phe Ile Arg Ile Ser Gly 
    50                  55                  60                  


Leu Arg Gly Lys Gly Ile Lys Ala Leu Ile Ala Ala Pro Leu Arg Ile 
65                  70                  75                  80  


Phe Asn Ala Trp Arg Gln Ala Arg Ala Ile Met Lys Ala Tyr Lys Pro 
                85                  90                  95      


Asp Val Val Leu Gly Met Gly Gly Tyr Val Ser Gly Pro Gly Gly Leu 
            100                 105                 110         


Ala Ala Trp Ser Leu Gly Ile Pro Val Val Leu His Glu Gln Asn Gly 
        115                 120                 125             


Ile Ala Gly Leu Thr Asn Lys Trp Leu Ala Lys Ile Ala Thr Lys Val 
    130                 135                 140                 


Met Gln Ala Phe Pro Gly Ala Phe Pro Asn Ala Glu Val Val Gly Asn 
145                 150                 155                 160 


Pro Val Arg Thr Asp Val Leu Ala Leu Pro Leu Pro Gln Gln Arg Leu 
                165                 170                 175     


Ala Gly Arg Glu Gly Pro Val Arg Val Leu Val Val Gly Gly Ser Gln 
            180                 185                 190         


Gly Ala Arg Ile Leu Asn Gln Thr Met Pro Gln Val Ala Ala Lys Leu 
        195                 200                 205             


Gly Asp Ser Val Thr Ile Trp His Gln Ser Gly Lys Gly Ser Gln Gln 
    210                 215                 220                 


Ser Val Glu Gln Ala Tyr Ala Glu Ala Gly Gln Pro Gln His Lys Val 
225                 230                 235                 240 


Thr Glu Phe Ile Asp Asp Met Ala Ala Ala Tyr Ala Trp Ala Asp Val 
                245                 250                 255     


Val Val Cys Arg Ser Gly Ala Leu Thr Val Ser Glu Ile Ala Ala Ala 
            260                 265                 270         


Gly Leu Pro Ala Leu Phe Val Pro Phe Gln His Lys Asp Arg Gln Gln 
        275                 280                 285             


Tyr Trp Asn Ala Leu Pro Leu Glu Lys Ala Gly Ala Ala Lys Ile Ile 
    290                 295                 300                 


Glu Gln Pro Gln Leu Ser Val Asp Ala Val Ala Asn Thr Leu Ala Gly 
305                 310                 315                 320 


Trp Ser Arg Glu Thr Leu Leu Thr Met Ala Glu Arg Ala Arg Ala Ala 
                325                 330                 335     


Ser Ile Pro Asp Ala Thr Glu Arg Val Ala Asn Glu Val Ser Arg Val 
            340                 345                 350         


Ala Arg Ala 
        355 


<210>  19
<211>  256
<212>  PRT
<213>  Bacillus subtilis

<400>  19

Met Pro Lys Val Ser Val Ile Met Thr Ser Tyr Asn Lys Ser Asp Tyr 
1               5                   10                  15      


Val Ala Lys Ser Ile Ser Ser Ile Leu Ser Gln Thr Phe Ser Asp Phe 
            20                  25                  30          


Glu Leu Phe Ile Met Asp Asp Asn Ser Asn Glu Glu Thr Leu Asn Val 
        35                  40                  45              


Ile Arg Pro Phe Leu Asn Asp Asn Arg Val Arg Phe Tyr Gln Ser Asp 
    50                  55                  60                  


Ile Ser Gly Val Lys Glu Arg Thr Glu Lys Thr Arg Tyr Ala Ala Leu 
65                  70                  75                  80  


Ile Asn Gln Ala Ile Glu Met Ala Glu Gly Glu Tyr Ile Thr Tyr Ala 
                85                  90                  95      


Thr Asp Asp Asn Ile Tyr Met Pro Asp Arg Leu Leu Lys Met Val Arg 
            100                 105                 110         


Glu Leu Asp Thr His Pro Glu Lys Ala Val Ile Tyr Ser Ala Ser Lys 
        115                 120                 125             


Thr Tyr His Leu Asn Glu Asn Arg Asp Ile Val Lys Glu Thr Val Arg 
    130                 135                 140                 


Pro Ala Ala Gln Val Thr Trp Asn Ala Pro Cys Ala Ile Asp His Cys 
145                 150                 155                 160 


Ser Val Met His Arg Tyr Ser Val Leu Glu Lys Val Lys Glu Lys Phe 
                165                 170                 175     


Gly Ser Tyr Trp Asp Glu Ser Pro Ala Phe Tyr Arg Ile Gly Asp Ala 
            180                 185                 190         


Arg Phe Phe Trp Arg Val Asn His Phe Tyr Pro Phe Tyr Pro Leu Asp 
        195                 200                 205             


Glu Glu Leu Asp Leu Asn Tyr Ile Thr Asp Gln Ser Ile His Phe Gln 
    210                 215                 220                 


Leu Phe Glu Leu Glu Lys Asn Glu Phe Val Arg Asn Leu Pro Pro Gln 
225                 230                 235                 240 


Arg Asn Cys Arg Glu Leu Arg Glu Ser Leu Lys Lys Leu Gly Met Gly 
                245                 250                 255     


<210>  20
<211>  372
<212>  PRT
<213>  Homo sapiens

<400>  20

Met Ser Arg Leu Leu Gly Gly Thr Leu Glu Arg Val Cys Lys Ala Val 
1               5                   10                  15      


Leu Leu Leu Cys Leu Leu His Phe Leu Val Ala Val Ile Leu Tyr Phe 
            20                  25                  30          


Asp Val Tyr Ala Gln His Leu Ala Phe Phe Ser Arg Phe Ser Ala Arg 
        35                  40                  45              


Gly Pro Ala His Ala Leu His Pro Ala Ala Ser Ser Ser Ser Ser Ser 
    50                  55                  60                  


Ser Asn Cys Ser Arg Pro Asn Ala Thr Ala Ser Ser Ser Gly Leu Pro 
65                  70                  75                  80  


Glu Val Pro Ser Ala Leu Pro Gly Pro Thr Ala Pro Thr Leu Pro Pro 
                85                  90                  95      


Cys Pro Asp Ser Pro Pro Gly Leu Val Gly Arg Leu Leu Ile Glu Phe 
            100                 105                 110         


Thr Ser Pro Met Pro Leu Glu Arg Val Gln Arg Glu Asn Pro Gly Val 
        115                 120                 125             


Leu Met Gly Gly Arg Tyr Thr Pro Pro Asp Cys Thr Pro Ala Gln Thr 
    130                 135                 140                 


Val Ala Val Ile Ile Pro Phe Arg His Arg Glu His His Leu Arg Tyr 
145                 150                 155                 160 


Trp Leu His Tyr Leu His Pro Ile Leu Arg Arg Gln Arg Leu Arg Tyr 
                165                 170                 175     


Gly Val Tyr Val Ile Asn Gln His Gly Glu Asp Thr Phe Asn Arg Ala 
            180                 185                 190         


Lys Leu Leu Asn Val Gly Phe Leu Glu Ala Leu Lys Glu Asp Ala Ala 
        195                 200                 205             


Tyr Asp Cys Phe Ile Phe Ser Asp Val Asp Leu Val Pro Met Asp Asp 
    210                 215                 220                 


Arg Asn Leu Tyr Arg Cys Gly Asp Gln Pro Arg His Phe Ala Ile Ala 
225                 230                 235                 240 


Met Asp Lys Phe Gly Phe Arg Leu Pro Tyr Ala Gly Tyr Phe Gly Gly 
                245                 250                 255     


Val Ser Gly Leu Ser Lys Ala Gln Phe Leu Arg Ile Asn Gly Phe Pro 
            260                 265                 270         


Asn Glu Tyr Trp Gly Trp Gly Gly Glu Asp Asp Asp Ile Phe Asn Arg 
        275                 280                 285             


Ile Ser Leu Thr Gly Met Lys Ile Ser Arg Pro Asp Ile Arg Ile Gly 
    290                 295                 300                 


Arg Tyr Arg Met Ile Lys His Asp Arg Asp Lys His Asn Glu Pro Asn 
305                 310                 315                 320 


Pro Gln Arg Phe Thr Lys Ile Gln Asn Thr Lys Leu Thr Met Lys Arg 
                325                 330                 335     


Asp Gly Ile Gly Ser Val Arg Tyr Gln Val Leu Glu Val Ser Arg Gln 
            340                 345                 350         


Pro Leu Phe Thr Asn Ile Thr Val Asp Ile Gly Arg Pro Pro Ser Trp 
        355                 360                 365             


Pro Pro Arg Gly 
    370         


<210>  21
<211>  393
<212>  PRT
<213>  Homo sapiens

<400>  21

Met Leu Arg Arg Leu Leu Glu Arg Pro Cys Thr Leu Ala Leu Leu Val 
1               5                   10                  15      


Gly Ser Gln Leu Ala Val Met Met Tyr Leu Ser Leu Gly Gly Phe Arg 
            20                  25                  30          


Ser Leu Ser Ala Leu Phe Gly Arg Asp Gln Gly Pro Thr Phe Asp Tyr 
        35                  40                  45              


Ser His Pro Arg Asp Val Tyr Ser Asn Leu Ser His Leu Pro Gly Ala 
    50                  55                  60                  


Pro Gly Gly Pro Pro Ala Pro Gln Gly Leu Pro Tyr Cys Pro Glu Arg 
65                  70                  75                  80  


Ser Pro Leu Leu Val Gly Pro Val Ser Val Ser Phe Ser Pro Val Pro 
                85                  90                  95      


Ser Leu Ala Glu Ile Val Glu Arg Asn Pro Arg Val Glu Pro Gly Gly 
            100                 105                 110         


Arg Tyr Arg Pro Ala Gly Cys Glu Pro Arg Ser Arg Thr Ala Ile Ile 
        115                 120                 125             


Val Pro His Arg Ala Arg Glu His His Leu Arg Leu Leu Leu Tyr His 
    130                 135                 140                 


Leu His Pro Phe Leu Gln Arg Gln Gln Leu Ala Tyr Gly Ile Tyr Val 
145                 150                 155                 160 


Ile His Gln Ala Gly Asn Gly Thr Phe Asn Arg Ala Lys Leu Leu Asn 
                165                 170                 175     


Val Gly Val Arg Glu Ala Leu Arg Asp Glu Glu Trp Asp Cys Leu Phe 
            180                 185                 190         


Leu His Asp Val Asp Leu Leu Pro Glu Asn Asp His Asn Leu Tyr Val 
        195                 200                 205             


Cys Asp Pro Arg Gly Pro Arg His Val Ala Val Ala Met Asn Lys Phe 
    210                 215                 220                 


Gly Tyr Ser Leu Pro Tyr Pro Gln Tyr Phe Gly Gly Val Ser Ala Leu 
225                 230                 235                 240 


Thr Pro Asp Gln Tyr Leu Lys Met Asn Gly Phe Pro Asn Glu Tyr Trp 
                245                 250                 255     


Gly Trp Gly Gly Glu Asp Asp Asp Ile Ala Thr Arg Val Arg Leu Ala 
            260                 265                 270         


Gly Met Lys Ile Ser Arg Pro Pro Thr Ser Val Gly His Tyr Lys Met 
        275                 280                 285             


Val Lys His Arg Gly Asp Lys Gly Asn Glu Glu Asn Pro His Arg Phe 
    290                 295                 300                 


Asp Leu Leu Val Arg Thr Gln Asn Ser Trp Thr Gln Asp Gly Met Asn 
305                 310                 315                 320 


Ser Leu Thr Tyr Gln Leu Leu Ala Arg Glu Leu Gly Pro Leu Tyr Thr 
                325                 330                 335     


Asn Ile Thr Ala Asp Ile Gly Thr Asp Pro Arg Gly Pro Arg Ala Pro 
            340                 345                 350         


Ser Gly Pro Arg Tyr Pro Pro Gly Ser Ser Gln Ala Phe Arg Gln Glu 
        355                 360                 365             


Met Leu Gln Arg Arg Pro Pro Ala Arg Pro Gly Pro Leu Ser Thr Ala 
    370                 375                 380                 


Asn His Thr Ala Leu Arg Gly Ser His 
385                 390             


<210>  22
<211>  344
<212>  PRT
<213>  Homo sapiens

<400>  22

Met Gly Phe Asn Leu Thr Phe His Leu Ser Tyr Lys Phe Arg Leu Leu 
1               5                   10                  15      


Leu Leu Leu Thr Leu Cys Leu Thr Val Val Gly Trp Ala Thr Ser Asn 
            20                  25                  30          


Tyr Phe Val Gly Ala Ile Gln Glu Ile Pro Lys Ala Lys Glu Phe Met 
        35                  40                  45              


Ala Asn Phe His Lys Thr Leu Ile Leu Gly Lys Gly Lys Thr Leu Thr 
    50                  55                  60                  


Asn Glu Ala Ser Thr Lys Lys Val Glu Leu Asp Asn Cys Pro Ser Val 
65                  70                  75                  80  


Ser Pro Tyr Leu Arg Gly Gln Ser Lys Leu Ile Phe Lys Pro Asp Leu 
                85                  90                  95      


Thr Leu Glu Glu Val Gln Ala Glu Asn Pro Lys Val Ser Arg Gly Arg 
            100                 105                 110         


Tyr Arg Pro Gln Glu Cys Lys Ala Leu Gln Arg Val Ala Ile Leu Val 
        115                 120                 125             


Pro His Arg Asn Arg Glu Lys His Leu Met Tyr Leu Leu Glu His Leu 
    130                 135                 140                 


His Pro Phe Leu Gln Arg Gln Gln Leu Asp Tyr Gly Ile Tyr Val Ile 
145                 150                 155                 160 


His Gln Ala Glu Gly Lys Lys Phe Asn Arg Ala Lys Leu Leu Asn Val 
                165                 170                 175     


Gly Tyr Leu Glu Ala Leu Lys Glu Glu Asn Trp Asp Cys Phe Ile Phe 
            180                 185                 190         


His Asp Val Asp Leu Val Pro Glu Asn Asp Phe Asn Leu Tyr Lys Cys 
        195                 200                 205             


Glu Glu His Pro Lys His Leu Val Val Gly Arg Asn Ser Thr Gly Tyr 
    210                 215                 220                 


Arg Leu Arg Tyr Ser Gly Tyr Phe Gly Gly Val Thr Ala Leu Ser Arg 
225                 230                 235                 240 


Glu Gln Phe Phe Lys Val Asn Gly Phe Ser Asn Asn Tyr Trp Gly Trp 
                245                 250                 255     


Gly Gly Glu Asp Asp Asp Leu Arg Leu Arg Val Glu Leu Gln Arg Met 
            260                 265                 270         


Lys Ile Ser Arg Pro Leu Pro Glu Val Gly Lys Tyr Thr Met Val Phe 
        275                 280                 285             


His Thr Arg Asp Lys Gly Asn Glu Val Asn Ala Glu Arg Met Lys Leu 
    290                 295                 300                 


Leu His Gln Val Ser Arg Val Trp Arg Thr Asp Gly Leu Ser Ser Cys 
305                 310                 315                 320 


Ser Tyr Lys Leu Val Ser Val Glu His Asn Pro Leu Tyr Ile Asn Ile 
                325                 330                 335     


Thr Val Asp Phe Trp Phe Gly Ala 
            340                 


<210>  23
<211>  388
<212>  PRT
<213>  Homo sapiens

<400>  23

Met Arg Ala Arg Arg Gly Leu Leu Arg Leu Pro Arg Arg Ser Leu Leu 
1               5                   10                  15      


Ala Ala Leu Phe Phe Phe Ser Leu Ser Ser Ser Leu Leu Tyr Phe Val 
            20                  25                  30          


Tyr Val Ala Pro Gly Ile Val Asn Thr Tyr Leu Phe Met Met Gln Ala 
        35                  40                  45              


Gln Gly Ile Leu Ile Arg Asp Asn Val Arg Thr Ile Gly Ala Gln Val 
    50                  55                  60                  


Tyr Glu Gln Val Leu Arg Ser Ala Tyr Ala Lys Arg Asn Ser Ser Val 
65                  70                  75                  80  


Asn Asp Ser Asp Tyr Pro Leu Asp Leu Asn His Ser Glu Thr Phe Leu 
                85                  90                  95      


Gln Thr Thr Thr Phe Leu Pro Glu Asp Phe Thr Tyr Phe Ala Asn His 
            100                 105                 110         


Thr Cys Pro Glu Arg Leu Pro Ser Met Lys Gly Pro Ile Asp Ile Asn 
        115                 120                 125             


Met Ser Glu Ile Gly Met Asp Tyr Ile His Glu Leu Phe Ser Lys Asp 
    130                 135                 140                 


Pro Thr Ile Lys Leu Gly Gly His Trp Lys Pro Ser Asp Cys Met Pro 
145                 150                 155                 160 


Arg Trp Lys Val Ala Ile Leu Ile Pro Phe Arg Asn Arg His Glu His 
                165                 170                 175     


Leu Pro Val Leu Phe Arg His Leu Leu Pro Met Leu Gln Arg Gln Arg 
            180                 185                 190         


Leu Gln Phe Ala Phe Tyr Val Val Glu Gln Val Gly Thr Gln Pro Phe 
        195                 200                 205             


Asn Arg Ala Met Leu Phe Asn Val Gly Phe Gln Glu Ala Met Lys Asp 
    210                 215                 220                 


Leu Asp Trp Asp Cys Leu Ile Phe His Asp Val Asp His Ile Pro Glu 
225                 230                 235                 240 


Ser Asp Arg Asn Tyr Tyr Gly Cys Gly Gln Met Pro Arg His Phe Ala 
                245                 250                 255     


Thr Lys Leu Asp Lys Tyr Met Tyr Leu Leu Pro Tyr Thr Glu Phe Phe 
            260                 265                 270         


Gly Gly Val Ser Gly Leu Thr Val Glu Gln Phe Arg Lys Ile Asn Gly 
        275                 280                 285             


Phe Pro Asn Ala Phe Trp Gly Trp Gly Gly Glu Asp Asp Asp Leu Trp 
    290                 295                 300                 


Asn Arg Val Gln Asn Ala Gly Tyr Ser Val Ser Arg Pro Glu Gly Asp 
305                 310                 315                 320 


Thr Gly Lys Tyr Lys Ser Ile Pro His His His Arg Gly Glu Val Gln 
                325                 330                 335     


Phe Leu Gly Arg Tyr Ala Leu Leu Arg Lys Ser Lys Glu Arg Gln Gly 
            340                 345                 350         


Leu Asp Gly Leu Asn Asn Leu Asn Tyr Phe Ala Asn Ile Thr Tyr Asp 
        355                 360                 365             


Ala Leu Tyr Lys Asn Ile Thr Val Asn Leu Thr Pro Glu Leu Ala Gln 
    370                 375                 380                 


Val Asn Glu Tyr 
385             


<210>  24
<211>  382
<212>  PRT
<213>  Homo sapiens

<400>  24

Met Ser Val Leu Arg Arg Met Met Arg Val Ser Asn Arg Ser Leu Leu 
1               5                   10                  15      


Ala Phe Ile Phe Phe Phe Ser Leu Ser Ser Ser Cys Leu Tyr Phe Ile 
            20                  25                  30          


Tyr Val Ala Pro Gly Ile Ala Asn Thr Tyr Leu Phe Met Val Gln Ala 
        35                  40                  45              


Arg Gly Ile Met Leu Arg Glu Asn Val Lys Thr Ile Gly His Met Ile 
    50                  55                  60                  


Arg Leu Tyr Thr Asn Lys Asn Ser Thr Leu Asn Gly Thr Asp Tyr Pro 
65                  70                  75                  80  


Glu Gly Asn Asn Ser Ser Asp Tyr Leu Val Gln Thr Thr Thr Tyr Leu 
                85                  90                  95      


Pro Glu Asn Phe Thr Tyr Ser Pro Tyr Leu Pro Cys Pro Glu Lys Leu 
            100                 105                 110         


Pro Tyr Met Arg Gly Phe Leu Asn Val Asn Val Ser Glu Val Ser Phe 
        115                 120                 125             


Asp Glu Ile His Gln Leu Phe Ser Lys Asp Leu Asp Ile Glu Pro Gly 
    130                 135                 140                 


Gly His Trp Arg Pro Lys Asp Cys Lys Pro Arg Trp Lys Val Ala Val 
145                 150                 155                 160 


Leu Ile Pro Phe Arg Asn Arg His Glu His Leu Pro Ile Phe Phe Leu 
                165                 170                 175     


His Leu Ile Pro Met Leu Gln Lys Gln Arg Leu Glu Phe Ala Phe Tyr 
            180                 185                 190         


Val Ile Glu Gln Thr Gly Thr Gln Pro Phe Asn Arg Ala Met Leu Phe 
        195                 200                 205             


Asn Val Gly Phe Lys Glu Ala Met Lys Asp Ser Val Trp Asp Cys Val 
    210                 215                 220                 


Ile Phe His Asp Val Asp His Leu Pro Glu Asn Asp Arg Asn Tyr Tyr 
225                 230                 235                 240 


Gly Cys Gly Glu Met Pro Arg His Phe Ala Ala Lys Leu Asp Lys Tyr 
                245                 250                 255     


Met Tyr Ile Leu Pro Tyr Lys Glu Phe Phe Gly Gly Val Ser Gly Leu 
            260                 265                 270         


Thr Val Glu Gln Phe Arg Lys Ile Asn Gly Phe Pro Asn Ala Phe Trp 
        275                 280                 285             


Gly Trp Gly Gly Glu Asp Asp Asp Leu Trp Asn Arg Val His Tyr Ala 
    290                 295                 300                 


Gly Tyr Asn Val Thr Arg Pro Glu Gly Asp Leu Gly Lys Tyr Lys Ser 
305                 310                 315                 320 


Ile Pro His His His Arg Gly Glu Val Gln Phe Leu Gly Arg Tyr Lys 
                325                 330                 335     


Leu Leu Arg Tyr Ser Lys Glu Arg Gln Tyr Ile Asp Gly Leu Asn Asn 
            340                 345                 350         


Leu Ile Tyr Arg Pro Lys Ile Leu Val Asp Arg Leu Tyr Thr Asn Ile 
        355                 360                 365             


Ser Val Asn Leu Met Pro Glu Leu Ala Pro Ile Glu Asp Tyr 
    370                 375                 380         


<210>  25
<211>  327
<212>  PRT
<213>  Homo sapiens

<400>  25

Met Phe Pro Ser Arg Arg Lys Ala Ala Gln Leu Pro Trp Glu Asp Gly 
1               5                   10                  15      


Arg Ser Gly Leu Leu Ser Gly Gly Leu Pro Arg Lys Cys Ser Val Phe 
            20                  25                  30          


His Leu Phe Val Ala Cys Leu Ser Leu Gly Phe Phe Ser Leu Leu Trp 
        35                  40                  45              


Leu Gln Leu Ser Cys Ser Gly Asp Val Ala Arg Ala Val Arg Gly Gln 
    50                  55                  60                  


Gly Gln Glu Thr Ser Gly Pro Pro Arg Ala Cys Pro Pro Glu Pro Pro 
65                  70                  75                  80  


Pro Glu His Trp Glu Glu Asp Ala Ser Trp Gly Pro His Arg Leu Ala 
                85                  90                  95      


Val Leu Val Pro Phe Arg Glu Arg Phe Glu Glu Leu Leu Val Phe Val 
            100                 105                 110         


Pro His Met Arg Arg Phe Leu Ser Arg Lys Lys Ile Arg His His Ile 
        115                 120                 125             


Tyr Val Leu Asn Gln Val Asp His Phe Arg Phe Asn Arg Ala Ala Leu 
    130                 135                 140                 


Ile Asn Val Gly Phe Leu Glu Ser Ser Asn Ser Thr Asp Tyr Ile Ala 
145                 150                 155                 160 


Met His Asp Val Asp Leu Leu Pro Leu Asn Glu Glu Leu Asp Tyr Gly 
                165                 170                 175     


Phe Pro Glu Ala Gly Pro Phe His Val Ala Ser Pro Glu Leu His Pro 
            180                 185                 190         


Leu Tyr His Tyr Lys Thr Tyr Val Gly Gly Ile Leu Leu Leu Ser Lys 
        195                 200                 205             


Gln His Tyr Arg Leu Cys Asn Gly Met Ser Asn Arg Phe Trp Gly Trp 
    210                 215                 220                 


Gly Arg Glu Asp Asp Glu Phe Tyr Arg Arg Ile Lys Gly Ala Gly Leu 
225                 230                 235                 240 


Gln Leu Phe Arg Pro Ser Gly Ile Thr Thr Gly Tyr Lys Thr Phe Arg 
                245                 250                 255     


His Leu His Asp Pro Ala Trp Arg Lys Arg Asp Gln Lys Arg Ile Ala 
            260                 265                 270         


Ala Gln Lys Gln Glu Gln Phe Lys Val Asp Arg Glu Gly Gly Leu Asn 
        275                 280                 285             


Thr Val Lys Tyr His Val Ala Ser Arg Thr Ala Leu Ser Val Gly Gly 
    290                 295                 300                 


Ala Pro Cys Thr Val Leu Asn Ile Met Leu Asp Cys Asp Lys Thr Ala 
305                 310                 315                 320 


Thr Pro Trp Cys Thr Phe Ser 
                325         


<210>  26
<211>  332
<212>  PRT
<213>  Streptococcus thermophilus

<400>  26

Met Ala Ile Leu Val Leu Gly Gly Ala Gly Tyr Ile Gly Ser His Met 
1               5                   10                  15      


Val Asp Arg Leu Val Glu Lys Gly Gln Glu Lys Val Val Val Val Asp 
            20                  25                  30          


Ser Leu Val Thr Gly His Arg Ala Ala Val His Pro Asp Ala Ile Phe 
        35                  40                  45              


Tyr Gln Gly Asp Leu Ser Asp Gln Asp Phe Met Arg Lys Val Phe Lys 
    50                  55                  60                  


Glu Asn Pro Asp Val Asp Ala Val Ile His Phe Ala Ala Tyr Ser Leu 
65                  70                  75                  80  


Val Gly Glu Ser Met Glu Lys Pro Leu Lys Tyr Phe Asp Asn Asn Thr 
                85                  90                  95      


Ala Gly Met Val Lys Leu Leu Glu Val Met Asn Glu Cys Gly Val Lys 
            100                 105                 110         


Tyr Ile Val Phe Ser Ser Thr Ala Ala Thr Tyr Gly Ile Pro Glu Glu 
        115                 120                 125             


Ile Pro Ile Leu Glu Thr Thr Pro Gln Asn Pro Ile Asn Pro Tyr Gly 
    130                 135                 140                 


Glu Ser Lys Leu Met Met Glu Thr Ile Met Lys Trp Ser Asp Gln Ala 
145                 150                 155                 160 


Tyr Gly Ile Lys Tyr Val Pro Leu Arg Tyr Phe Asn Val Ala Gly Ala 
                165                 170                 175     


Asn Leu Met Val Arg Leu Val Arg Thr Arg Ser Glu Thr His Leu Leu 
            180                 185                 190         


Pro Ile Ile Leu Gln Val Ala Gln Gly Val Arg Glu Lys Ile Met Ile 
        195                 200                 205             


Phe Gly Asp Asp Tyr Asn Thr Pro Asp Gly Thr Asn Val Arg Asp Tyr 
    210                 215                 220                 


Val His Pro Phe Asp Leu Ala Asp Ala His Leu Leu Ala Val Glu Tyr 
225                 230                 235                 240 


Leu Arg Lys Gly Asn Glu Ser Thr Ala Phe Asn Leu Gly Ser Ser Thr 
                245                 250                 255     


Gly Phe Ser Asn Leu Gln Ile Leu Glu Ala Ala Arg Lys Val Thr Gly 
            260                 265                 270         


Lys Glu Ile Pro Ala Glu Lys Ala Asp Arg Arg Pro Gly Asp Pro Asp 
        275                 280                 285             


Ile Leu Ile Ala Ser Ser Glu Lys Ala Arg Thr Val Leu Gly Trp Lys 
    290                 295                 300                 


Pro Gln Phe Asp Asn Ile Glu Lys Ile Ile Ala Ser Ala Trp Ala Trp 
305                 310                 315                 320 


His Ser Ser His Pro Lys Gly Tyr Asp Asp Arg Gly 
                325                 330         


<210>  27
<211>  348
<212>  PRT
<213>  Homo sapiens

<400>  27

Met Ala Glu Lys Val Leu Val Thr Gly Gly Ala Gly Tyr Ile Gly Ser 
1               5                   10                  15      


His Thr Val Leu Glu Leu Leu Glu Ala Gly Tyr Leu Pro Val Val Ile 
            20                  25                  30          


Asp Asn Phe His Asn Ala Phe Arg Gly Gly Gly Ser Leu Pro Glu Ser 
        35                  40                  45              


Leu Arg Arg Val Gln Glu Leu Thr Gly Arg Ser Val Glu Phe Glu Glu 
    50                  55                  60                  


Met Asp Ile Leu Asp Gln Gly Ala Leu Gln Arg Leu Phe Lys Lys Tyr 
65                  70                  75                  80  


Ser Phe Met Ala Val Ile His Phe Ala Gly Leu Lys Ala Val Gly Glu 
                85                  90                  95      


Ser Val Gln Lys Pro Leu Asp Tyr Tyr Arg Val Asn Leu Thr Gly Thr 
            100                 105                 110         


Ile Gln Leu Leu Glu Ile Met Lys Ala His Gly Val Lys Asn Leu Val 
        115                 120                 125             


Phe Ser Ser Ser Ala Thr Val Tyr Gly Asn Pro Gln Tyr Leu Pro Leu 
    130                 135                 140                 


Asp Glu Ala His Pro Thr Gly Gly Cys Thr Asn Pro Tyr Gly Lys Ser 
145                 150                 155                 160 


Lys Phe Phe Ile Glu Glu Met Ile Arg Asp Leu Cys Gln Ala Asp Lys 
                165                 170                 175     


Thr Trp Asn Ala Val Leu Leu Arg Tyr Phe Asn Pro Thr Gly Ala His 
            180                 185                 190         


Ala Ser Gly Cys Ile Gly Glu Asp Pro Gln Gly Ile Pro Asn Asn Leu 
        195                 200                 205             


Met Pro Tyr Val Ser Gln Val Ala Ile Gly Arg Arg Glu Ala Leu Asn 
    210                 215                 220                 


Val Phe Gly Asn Asp Tyr Asp Thr Glu Asp Gly Thr Gly Val Arg Asp 
225                 230                 235                 240 


Tyr Ile His Val Val Asp Leu Ala Lys Gly His Ile Ala Ala Leu Arg 
                245                 250                 255     


Lys Leu Lys Glu Gln Cys Gly Cys Arg Ile Tyr Asn Leu Gly Thr Gly 
            260                 265                 270         


Thr Gly Tyr Ser Val Leu Gln Met Val Gln Ala Met Glu Lys Ala Ser 
        275                 280                 285             


Gly Lys Lys Ile Pro Tyr Lys Val Val Ala Arg Arg Glu Gly Asp Val 
    290                 295                 300                 


Ala Ala Cys Tyr Ala Asn Pro Ser Leu Ala Gln Glu Glu Leu Gly Trp 
305                 310                 315                 320 


Thr Ala Ala Leu Gly Leu Asp Arg Met Cys Glu Asp Leu Trp Arg Trp 
                325                 330                 335     


Gln Lys Gln Asn Pro Ser Gly Phe Gly Thr Gln Ala 
            340                 345             


<210>  28
<211>  338
<212>  PRT
<213>  Escherichia coli

<400>  28

Met Arg Val Leu Val Thr Gly Gly Ser Gly Tyr Ile Gly Ser His Thr 
1               5                   10                  15      


Cys Val Gln Leu Leu Gln Asn Gly His Asp Val Ile Ile Leu Asp Asn 
            20                  25                  30          


Leu Cys Asn Ser Lys Arg Ser Val Leu Pro Val Ile Glu Arg Leu Gly 
        35                  40                  45              


Gly Lys His Pro Thr Phe Val Glu Gly Asp Ile Arg Asn Glu Ala Leu 
    50                  55                  60                  


Met Thr Glu Ile Leu His Asp His Ala Ile Asp Thr Val Ile His Phe 
65                  70                  75                  80  


Ala Gly Leu Lys Ala Val Gly Glu Ser Val Gln Lys Pro Leu Glu Tyr 
                85                  90                  95      


Tyr Asp Asn Asn Val Asn Gly Thr Leu Arg Leu Ile Ser Ala Met Arg 
            100                 105                 110         


Ala Ala Asn Val Lys Asn Phe Ile Phe Ser Ser Ser Ala Thr Val Tyr 
        115                 120                 125             


Gly Asp Gln Pro Lys Ile Pro Tyr Val Glu Ser Phe Pro Thr Gly Thr 
    130                 135                 140                 


Pro Gln Ser Pro Tyr Gly Lys Ser Lys Leu Met Val Glu Gln Ile Leu 
145                 150                 155                 160 


Thr Asp Leu Gln Lys Ala Gln Pro Asp Trp Ser Ile Ala Leu Leu Arg 
                165                 170                 175     


Tyr Phe Asn Pro Val Gly Ala His Pro Ser Gly Asp Met Gly Glu Asp 
            180                 185                 190         


Pro Gln Gly Ile Pro Asn Asn Leu Met Pro Tyr Ile Ala Gln Val Ala 
        195                 200                 205             


Val Gly Arg Arg Asp Ser Leu Ala Ile Phe Gly Asn Asp Tyr Pro Thr 
    210                 215                 220                 


Glu Asp Gly Thr Gly Val Arg Asp Tyr Ile His Val Met Asp Leu Ala 
225                 230                 235                 240 


Asp Gly His Val Val Ala Met Glu Lys Leu Ala Asn Lys Pro Gly Val 
                245                 250                 255     


His Ile Tyr Asn Leu Gly Ala Gly Val Gly Asn Ser Val Leu Asp Val 
            260                 265                 270         


Val Asn Ala Phe Ser Lys Ala Cys Gly Lys Pro Val Asn Tyr His Phe 
        275                 280                 285             


Ala Pro Arg Arg Glu Gly Asp Leu Pro Ala Tyr Trp Ala Asp Ala Ser 
    290                 295                 300                 


Lys Ala Asp Arg Glu Leu Asn Trp Arg Val Thr Arg Thr Leu Asp Glu 
305                 310                 315                 320 


Met Ala Gln Asp Thr Trp His Trp Gln Ser Arg His Pro Gln Gly Tyr 
                325                 330                 335     


Pro Asp 
        


<210>  29
<211>  338
<212>  PRT
<213>  Haemophilus influenzae

<400>  29

Met Ala Ile Leu Val Thr Gly Gly Ala Gly Tyr Ile Gly Ser His Thr 
1               5                   10                  15      


Val Val Glu Leu Leu Asn Val Gly Lys Glu Val Val Val Leu Asp Asn 
            20                  25                  30          


Leu Cys Asn Ser Ser Pro Lys Ser Leu Glu Arg Val Lys Gln Ile Thr 
        35                  40                  45              


Gly Lys Glu Ala Lys Phe Tyr Glu Gly Asp Ile Leu Asp Arg Ala Leu 
    50                  55                  60                  


Leu Gln Lys Ile Phe Ala Glu Asn Glu Ile Asn Ser Val Ile His Phe 
65                  70                  75                  80  


Ala Gly Leu Lys Ala Val Gly Glu Ser Val Gln Lys Pro Thr Glu Tyr 
                85                  90                  95      


Tyr Met Asn Asn Val Ala Gly Thr Leu Val Leu Ile Gln Glu Met Lys 
            100                 105                 110         


Lys Ala Gly Val Trp Asn Phe Val Phe Ser Ser Ser Ala Thr Val Tyr 
        115                 120                 125             


Gly Asp Pro Lys Ile Ile Pro Ile Thr Glu Asp Cys Glu Val Gly Gly 
    130                 135                 140                 


Thr Thr Asn Pro Tyr Gly Thr Ser Lys Tyr Met Val Glu Gln Ile Leu 
145                 150                 155                 160 


Arg Asp Thr Ala Lys Ala Glu Pro Lys Phe Ser Met Thr Ile Leu Arg 
                165                 170                 175     


Tyr Phe Asn Pro Val Gly Ala His Glu Ser Gly Leu Ile Gly Glu Asp 
            180                 185                 190         


Pro Asn Gly Ile Pro Asn Asn Leu Leu Pro Tyr Ile Ser Gln Val Ala 
        195                 200                 205             


Ile Gly Lys Leu Ala Gln Leu Ser Val Phe Gly Ser Asp Tyr Asp Thr 
    210                 215                 220                 


His Asp Gly Thr Gly Val Arg Asp Tyr Ile His Val Val Asp Leu Ala 
225                 230                 235                 240 


Val Gly His Leu Lys Ala Leu Gln Arg His Glu Asn Asp Ala Gly Leu 
                245                 250                 255     


His Ile Tyr Asn Leu Gly Thr Gly His Gly Tyr Ser Val Leu Asp Met 
            260                 265                 270         


Val Lys Ala Phe Glu Lys Ala Asn Asn Ile Thr Ile Ala Tyr Lys Leu 
        275                 280                 285             


Val Glu Arg Arg Ser Gly Asp Ile Ala Thr Cys Tyr Ser Asp Pro Ser 
    290                 295                 300                 


Leu Ala Ala Lys Glu Leu Gly Trp Val Ala Glu Arg Gly Leu Glu Lys 
305                 310                 315                 320 


Met Met Gln Asp Thr Trp Asn Trp Gln Lys Asn Asn Pro Lys Gly Tyr 
                325                 330                 335     


Arg Asp 
        


<210>  30
<211>  339
<212>  PRT
<213>  Neisseria meningitides

<400>  30

Met Lys Lys Ile Leu Val Thr Gly Gly Thr Gly Phe Ile Gly Ser His 
1               5                   10                  15      


Thr Val Val Ser Leu Leu Lys Ser Gly His Gln Val Val Ile Leu Asp 
            20                  25                  30          


Asn Leu Cys Asn Ser Ser Ile Asn Ile Leu Pro Arg Leu Lys Thr Ile 
        35                  40                  45              


Thr Gly Gln Glu Ile Pro Phe Tyr Gln Gly Asp Ile Arg Asp Arg Glu 
    50                  55                  60                  


Ile Leu Arg Arg Ile Phe Ala Glu Asn Arg Ile Asp Ser Val Ile His 
65                  70                  75                  80  


Phe Ala Gly Leu Lys Ala Val Gly Glu Ser Val Ala Glu Pro Met Lys 
                85                  90                  95      


Tyr Tyr Asp Asn Asn Val Ser Gly Ser Leu Val Leu Ala Glu Glu Met 
            100                 105                 110         


Ala Arg Ala Gly Val Phe Ser Ile Val Phe Ser Ser Ser Ala Thr Val 
        115                 120                 125             


Tyr Gly Asp Pro Gly Lys Val Pro Tyr Thr Glu Asp Met Pro Pro Gly 
    130                 135                 140                 


Asp Thr Thr Ser Pro Tyr Gly Ala Ser Lys Ser Met Val Glu Arg Ile 
145                 150                 155                 160 


Leu Thr Asp Ile Gln Lys Ala Asp Pro Arg Trp Ser Met Ile Leu Leu 
                165                 170                 175     


Arg Tyr Phe Asn Pro Ile Gly Ala His Glu Ser Gly Leu Ile Gly Glu 
            180                 185                 190         


Gln Pro Asn Gly Ile Pro Asn Asn Leu Leu Pro Tyr Ile Cys Gln Val 
        195                 200                 205             


Ala Ala Gly Lys Leu Pro Gln Leu Ala Val Phe Gly Asp Asp Tyr Pro 
    210                 215                 220                 


Thr Pro Asp Gly Thr Gly Met Arg Asp Tyr Ile His Val Met Asp Leu 
225                 230                 235                 240 


Ala Glu Gly His Val Ala Ala Met Gln Ala Lys Ser Asn Val Ala Gly 
                245                 250                 255     


Thr His Leu Leu Asn Leu Gly Ser Gly Arg Ala Ser Ser Val Leu Glu 
            260                 265                 270         


Ile Ile Arg Ala Phe Glu Ala Ala Ser Gly Leu Thr Ile Pro Tyr Glu 
        275                 280                 285             


Val Lys Pro Arg Arg Ala Gly Asp Leu Ala Cys Phe Tyr Ala Asp Pro 
    290                 295                 300                 


Ser Tyr Thr Lys Ala Gln Ile Gly Trp Gln Thr Gln Arg Asp Leu Thr 
305                 310                 315                 320 


Gln Met Met Glu Asp Ser Trp Arg Trp Val Ser Asn Asn Pro Asn Gly 
                325                 330                 335     


Tyr Asp Asp 
            


<210>  31
<211>  395
<212>  PRT
<213>  Trypanosoma brucei

<400>  31

Met Arg Val Leu Val Cys Gly Gly Ala Gly Tyr Ile Gly Ser His Phe 
1               5                   10                  15      


Val Arg Ala Leu Leu Arg Asp Thr Asn His Ser Val Val Ile Val Asp 
            20                  25                  30          


Ser Leu Val Gly Thr His Gly Lys Ser Asp His Val Glu Thr Arg Glu 
        35                  40                  45              


Asn Val Ala Arg Lys Leu Gln Gln Ser Asp Gly Pro Lys Pro Pro Trp 
    50                  55                  60                  


Ala Asp Arg Tyr Ala Ala Leu Glu Val Gly Asp Val Arg Asn Glu Asp 
65                  70                  75                  80  


Phe Leu Asn Gly Val Phe Thr Arg His Gly Pro Ile Asp Ala Val Val 
                85                  90                  95      


His Met Cys Ala Phe Leu Ala Val Gly Glu Ser Val Arg Asp Pro Leu 
            100                 105                 110         


Lys Tyr Tyr Asp Asn Asn Val Val Gly Ile Leu Arg Leu Leu Gln Ala 
        115                 120                 125             


Met Leu Leu His Lys Cys Asp Lys Ile Ile Phe Ser Ser Ser Ala Ala 
    130                 135                 140                 


Ile Phe Gly Asn Pro Thr Met Gly Ser Val Ser Thr Asn Ala Glu Pro 
145                 150                 155                 160 


Ile Asp Ile Asn Ala Lys Lys Ser Pro Glu Ser Pro Tyr Gly Glu Ser 
                165                 170                 175     


Lys Leu Ile Ala Glu Arg Met Ile Arg Asp Cys Ala Glu Ala Tyr Gly 
            180                 185                 190         


Ile Lys Gly Ile Cys Leu Arg Tyr Phe Asn Ala Cys Gly Ala His Glu 
        195                 200                 205             


Asp Gly Asp Ile Gly Glu His Tyr Gln Gly Ser Thr His Leu Ile Pro 
    210                 215                 220                 


Ile Ile Leu Gly Arg Val Met Ser Asp Ile Ala Pro Asp Gln Arg Leu 
225                 230                 235                 240 


Thr Ile His Glu Asp Ala Ser Thr Asp Lys Arg Met Pro Ile Phe Gly 
                245                 250                 255     


Thr Asp Tyr Pro Thr Pro Asp Gly Thr Cys Val Arg Asp Tyr Val His 
            260                 265                 270         


Val Cys Asp Leu Ala Ser Ala His Ile Leu Ala Leu Asp Tyr Val Glu 
        275                 280                 285             


Lys Leu Gly Pro Asn Asp Lys Ser Lys Tyr Phe Ser Val Phe Asn Leu 
    290                 295                 300                 


Gly Thr Ser Arg Gly Tyr Ser Val Arg Glu Val Ile Glu Val Ala Arg 
305                 310                 315                 320 


Lys Thr Thr Gly His Pro Ile Pro Val Arg Glu Cys Gly Arg Arg Glu 
                325                 330                 335     


Gly Asp Pro Ala Tyr Leu Val Ala Ala Ser Asp Lys Ala Arg Glu Val 
            340                 345                 350         


Leu Gly Trp Lys Pro Lys Tyr Asp Thr Leu Glu Ala Ile Met Glu Thr 
        355                 360                 365             


Ser Trp Lys Phe Gln Arg Thr His Pro Asn Gly Tyr Ala Ser Gln Glu 
    370                 375                 380                 


Asn Gly Thr Pro Gly Gly Arg Thr Thr Lys Leu 
385                 390                 395 


<210>  32
<211>  367
<212>  PRT
<213>  Escherichia coli

<400>  32

Met Tyr Asp Tyr Ile Ile Val Gly Ser Gly Leu Phe Gly Ala Val Cys 
1               5                   10                  15      


Ala Asn Glu Leu Lys Lys Leu Asn Lys Lys Val Leu Val Ile Glu Lys 
            20                  25                  30          


Arg Asn His Ile Gly Gly Asn Ala Tyr Thr Glu Asp Cys Glu Gly Ile 
        35                  40                  45              


Gln Ile His Lys Tyr Gly Ala His Ile Phe His Thr Asn Asp Lys Tyr 
    50                  55                  60                  


Ile Trp Asp Tyr Val Asn Asp Leu Val Glu Phe Asn Arg Phe Thr Asn 
65                  70                  75                  80  


Ser Pro Leu Ala Ile Tyr Lys Asp Lys Leu Phe Asn Leu Pro Phe Asn 
                85                  90                  95      


Met Asn Thr Phe His Gln Met Trp Gly Val Lys Asp Pro Gln Glu Ala 
            100                 105                 110         


Gln Asn Ile Ile Asn Ala Gln Lys Lys Lys Tyr Gly Asp Lys Val Pro 
        115                 120                 125             


Glu Asn Leu Glu Glu Gln Ala Ile Ser Leu Val Gly Glu Asp Leu Tyr 
    130                 135                 140                 


Gln Ala Leu Ile Lys Gly Tyr Thr Glu Lys Gln Trp Gly Arg Ser Ala 
145                 150                 155                 160 


Lys Glu Leu Pro Ala Phe Ile Ile Lys Arg Ile Pro Val Arg Phe Thr 
                165                 170                 175     


Phe Asp Asn Asn Tyr Phe Ser Asp Arg Tyr Gln Gly Ile Pro Val Gly 
            180                 185                 190         


Gly Tyr Thr Lys Leu Ile Glu Lys Met Leu Glu Gly Val Asp Val Lys 
        195                 200                 205             


Leu Gly Ile Asp Phe Leu Lys Asp Lys Asp Ser Leu Ala Ser Lys Ala 
    210                 215                 220                 


His Arg Ile Ile Tyr Thr Gly Pro Ile Asp Gln Tyr Phe Asp Tyr Arg 
225                 230                 235                 240 


Phe Gly Ala Leu Glu Tyr Arg Ser Leu Lys Phe Glu Thr Glu Arg His 
                245                 250                 255     


Glu Phe Pro Asn Phe Gln Gly Asn Ala Val Ile Asn Phe Thr Asp Ala 
            260                 265                 270         


Asn Val Pro Tyr Thr Arg Ile Ile Glu His Lys His Phe Asp Tyr Val 
        275                 280                 285             


Glu Thr Lys His Thr Val Val Thr Lys Glu Tyr Pro Leu Glu Trp Lys 
    290                 295                 300                 


Val Gly Asp Glu Pro Tyr Tyr Pro Val Asn Asp Asn Lys Asn Met Glu 
305                 310                 315                 320 


Leu Phe Lys Lys Tyr Arg Glu Leu Ala Ser Arg Glu Asp Lys Val Ile 
                325                 330                 335     


Phe Gly Gly Arg Leu Ala Glu Tyr Lys Tyr Tyr Asp Met His Gln Val 
            340                 345                 350         


Ile Ser Ala Ala Leu Tyr Gln Val Lys Asn Ile Met Ser Thr Asp 
        355                 360                 365         


<210>  33
<211>  404
<212>  PRT
<213>  Mycoplasma genitalium

<400>  33

Met Asn Val Ile Leu Ser Val Met Leu Phe Ser Ser Pro Ser Cys Val 
1               5                   10                  15      


Asn Ile Asn Ser Phe Asp Ile Leu Ile Val Gly Ala Gly Ile Ser Gly 
            20                  25                  30          


Ile Val Leu Ala Asn Ile Leu Ala Asn His Asn Lys Arg Val Leu Ile 
        35                  40                  45              


Val Glu Lys Arg Asp His Ile Gly Gly Asn Cys Tyr Asp Lys Val Asp 
    50                  55                  60                  


Ser Lys Thr Gln Leu Leu Phe His Gln Tyr Gly Pro His Ile Phe His 
65                  70                  75                  80  


Thr Asn Asn Gln Thr Val Ile Asn Phe Ile Ser Pro Phe Phe Glu Leu 
                85                  90                  95      


Asn Asn Tyr His His Arg Val Gly Leu Lys Leu Lys Asn Asn Leu Asp 
            100                 105                 110         


Leu Thr Leu Pro Phe Asp Phe Gln Gln Ile Tyr Lys Leu Met Gly Lys 
        115                 120                 125             


Asp Gly Arg Lys Leu Val Ser Phe Phe Lys Glu Asn Phe Ser Leu Asn 
    130                 135                 140                 


Thr His Leu Ser Leu Ala Glu Leu Gln Leu Ile Asp Asn Pro Leu Ala 
145                 150                 155                 160 


Gln Lys Leu Tyr Gln Phe Leu Ile Ser Asn Val Tyr Lys Pro Tyr Ser 
                165                 170                 175     


Val Lys Met Trp Gly Leu Pro Phe Ala Met Ile Asn Glu Asn Val Ile 
            180                 185                 190         


Asn Arg Val Lys Ile Val Leu Ser Glu Gln Ser Ser Tyr Phe Pro Asp 
        195                 200                 205             


Ala Ile Ile Gln Gly Leu Pro Lys Ser Gly Tyr Thr Asn Ser Phe Leu 
    210                 215                 220                 


Lys Met Leu Ala Asn Pro Leu Ile Asp Val Gln Leu Asn Cys Lys Asp 
225                 230                 235                 240 


Asn Leu Leu Val Tyr Gln Asp Glu Lys Leu Phe Phe Asn Asn Asn Leu 
                245                 250                 255     


Ile Glu Lys Pro Val Val Tyr Cys Gly Leu Ile Asp Lys Leu Phe Asn 
            260                 265                 270         


Phe Cys Phe Gly His Leu Gln Tyr Arg Ser Leu Ala Phe Ser Trp Lys 
        275                 280                 285             


Arg Phe Asn Gln Lys Lys Tyr Gln Thr Tyr Pro Val Val Asn Met Pro 
    290                 295                 300                 


Leu Ala Lys Ser Ile Thr Arg Ser Val Glu Tyr Lys Gln Leu Thr Asn 
305                 310                 315                 320 


Gln Gly Ser Phe Lys Pro Gln Thr Ile Val Ser Phe Glu Thr Pro Gly 
                325                 330                 335     


Ser Tyr Ala Ile Asn Asp Pro Arg Phe Asn Glu Pro Tyr Tyr Pro Ile 
            340                 345                 350         


Asn Asn Thr Leu Asn Asp Thr Leu Phe Lys Lys Tyr Trp Lys Lys Ala 
        355                 360                 365             


Ser Lys Leu Lys Asn Leu His Leu Leu Gly Arg Leu Ala Thr Tyr Gln 
    370                 375                 380                 


Tyr Ile Asp Met Asp Lys Ala Ile Leu Leu Ser Ile Lys Lys Ala Gln 
385                 390                 395                 400 


Gln Leu Leu Ser 
                


