                         SEQUENCE LISTING

<110>  Isis Innovation Limited
 
<120>  Treatment of Obesity

<130>  HB/P41809GB

<160>  12    

<170>  PatentIn version 3.3

<210>  1
<211>  199
<212>  PRT
<213>  Homo sapiens

<400>  1

Met Thr Leu His Pro Ser Pro Ile Thr Cys Glu Phe Leu Phe Ser Thr 
1               5                   10                  15      


Ala Leu Ile Ser Pro Lys Met Cys Leu Ser His Leu Glu Asn Met Pro 
            20                  25                  30          


Leu Ser His Ser Arg Thr Gln Gly Ala Gln Arg Ser Ser Trp Lys Leu 
        35                  40                  45              


Trp Leu Phe Cys Ser Ile Val Met Leu Leu Phe Leu Cys Ser Phe Ser 
    50                  55                  60                  


Trp Leu Ile Phe Ile Phe Leu Gln Leu Glu Thr Ala Lys Glu Pro Cys 
65                  70                  75                  80  


Met Ala Lys Phe Gly Pro Leu Pro Ser Lys Trp Gln Met Ala Ser Ser 
                85                  90                  95      


Glu Pro Pro Cys Val Asn Lys Val Ser Asp Trp Lys Leu Glu Ile Leu 
            100                 105                 110         


Gln Asn Gly Leu Tyr Leu Ile Tyr Gly Gln Val Ala Pro Asn Ala Asn 
        115                 120                 125             


Tyr Asn Asp Val Ala Pro Phe Glu Val Arg Leu Tyr Lys Asn Lys Asp 
    130                 135                 140                 


Met Ile Gln Thr Leu Thr Asn Lys Ser Lys Ile Gln Asn Val Gly Gly 
145                 150                 155                 160 


Thr Tyr Glu Leu His Val Gly Asp Thr Ile Asp Leu Ile Phe Asn Ser 
                165                 170                 175     


Glu His Gln Val Leu Lys Asn Asn Thr Tyr Trp Gly Ile Ile Leu Leu 
            180                 185                 190         


Ala Asn Pro Gln Phe Ile Ser 
        195                 


<210>  2
<211>  748
<212>  DNA
<213>  Homo sapiens

<400>  2
catgacattg catccttcac ccatcacttg tgaatttttg ttttccacag ctctcatttc     60

tccaaaaatg tgtttgagcc acttggaaaa tatgccttta agccattcaa gaactcaagg    120

agctcagaga tcatcctgga agctgtggct cttttgctca atagttatgt tgctatttct    180

ttgctccttc agttggctaa tctttatttt tctccaatta gagactgcta aggagccctg    240

tatggctaag tttggaccat taccctcaaa atggcaaatg gcatcttctg aacctccttg    300

cgtgaataag gtgtctgact ggaagctgga gatacttcag aatggcttat atttaattta    360

tggccaagtg gctcccaatg caaactacaa tgatgtagct ccttttgagg tgcggctgta    420

taaaaacaaa gacatgatac aaactctaac aaacaaatct aaaatccaaa atgtaggagg    480

gacttatgaa ttgcatgttg gggacaccat agacttgata ttcaactctg agcatcaggt    540

tctaaaaaat aatacatact ggggtatcat tttactagca aatccccaat tcatctccta    600

gagacttgat ttgatctcct cattcccttc agcacatgta gaggtgccag tgggtggatt    660

ggagggagaa gatattcaat ttctagagtt tgtctgtcta caaaaatcaa cacaaacaga    720

actcctctgc acgtgaattt tcatctat                                       748


<210>  3
<211>  173
<212>  PRT
<213>  Mus musculus

<400>  3

Met Glu Glu Met Pro Leu Arg Glu Ser Ser Pro Gln Arg Ala Glu Arg 
1               5                   10                  15      


Cys Lys Lys Ser Trp Leu Leu Cys Ile Val Ala Leu Leu Leu Met Leu 
            20                  25                  30          


Leu Cys Ser Leu Gly Thr Leu Ile Tyr Thr Ser Leu Lys Pro Thr Ala 
        35                  40                  45              


Ile Glu Ser Cys Met Val Lys Phe Glu Leu Ser Ser Ser Lys Trp His 
    50                  55                  60                  


Met Thr Ser Pro Lys Pro His Cys Val Asn Thr Thr Ser Asp Gly Lys 
65                  70                  75                  80  


Leu Lys Ile Leu Gln Ser Gly Thr Tyr Leu Ile Tyr Gly Gln Val Ile 
                85                  90                  95      


Pro Val Asp Lys Lys Tyr Ile Lys Asp Asn Ala Pro Phe Val Val Gln 
            100                 105                 110         


Ile Tyr Lys Lys Asn Asp Val Leu Gln Thr Leu Met Asn Asp Phe Gln 
        115                 120                 125             


Ile Leu Pro Ile Gly Gly Val Tyr Glu Leu His Ala Gly Asp Asn Ile 
    130                 135                 140                 


Tyr Leu Lys Phe Asn Ser Lys Asp His Ile Gln Lys Asn Asn Thr Tyr 
145                 150                 155                 160 


Trp Gly Ile Ile Leu Met Pro Asp Leu Pro Phe Ile Ser 
                165                 170             


<210>  4
<211>  2064
<212>  DNA
<213>  Mus musculus

<400>  4
ttgtgggtat ctgctttccc cagttctcat tccatcagag aacgagttct agcctcatgg     60

aggaaatgcc tttgagagaa tcaagtcctc aaagggcaga gaggtgcaag aagtcatggc    120

tcttgtgcat agtggctctg ttactgatgt tgctctgttc tttgggtaca ctgatctata    180

cttcactcaa gccaactgcc atcgagtcct gcatggttaa gtttgaacta tcatcctcaa    240

aatggcacat gacatctccc aaacctcact gtgtgaatac gacatctgat gggaagctga    300

agatactgca gagtggcaca tatttaatct acggccaagt gattcctgtg gataagaaat    360

acataaaaga caatgccccc ttcgtagtac agatatataa aaagaatgat gtcctacaaa    420

ctctaatgaa tgattttcaa atcttgccta taggaggggt ttatgaactg catgctggag    480

ataacatata tctgaagttc aactctaaag accatattca gaaaactaac acatactggg    540

ggatcatctt aatgcctgat ctaccattca tctcttagag attgggtttg gtctcctcat    600

cttcttcttt gtatcccgag atgctggtgg gtgggttgga gggggatgat tgatggcaat    660

gcacacagtt tgtgagggct tacaaattga cacaatcaga gcctcttggc atataaaatt    720

ttagccctca tatctgtctg aagaggactc agcaaatggg ccaatcccta atgttgggtc    780

tgcaaatgga cttgtacaat ccatgataaa aaggagtatg ggccacagaa gacagaaact    840

cttccaaaga atgtctttct aaccttgatc cctgggtaga atgagatcct gtttccatgg    900

gagtcttact tggcttgcaa aaaagggtgt agggcagtag cttggccttt tttccatcat    960

aatttccttg agctgtttta ccttaatccc tccaaactct caccttctga gagcctccta   1020

atgaaacatt gttagactgg tggggtggcc aagacatgcc aacaacaccc ttctttagag   1080

gtggtgtttt tagaggacag agaacattat gaagcctaga gcagcagagg tcaagatgcc   1140

acgaaatgga attgatctgg gaattttttt tttttttcat tctcaggatg caggttcatt   1200

ctgaactttc ccctaggcct tcattgcttt tgtgtgtatg tgtgcataaa ttctgcaaat   1260

agaaaaatga gagtttgcac cagtactcac tagatttaac accagaaagt ggtacttttc   1320

tggctgtatt atgccatgat agcacatttt ctgttggtgt tccctaactg acaagtataa   1380

cagttttcct aaaccacaca acaatgctat gatgttaatg gggtagatat ttttggaaaa   1440

aaattgcaca gtgagaacat gggtagatga accctaagac tcttacctca attcagaact   1500

cgcaaggagt taagtgagtg gggtcttcat tagaccattc acatggtctc tgctttgaaa   1560

ctggcgttgc tactgtctca ttatacatca ctaaaatgga attaactcaa ctttgaaatg   1620

gatgcatcga ctttacccca aggtgtccag aatgaagcta caagactttt accagcagtc   1680

attttccttt tgcctggagc aagaagatcc aggatactgt tggaagagtt catctcactc   1740

aaccatgctg actttccaaa gtaataatga acatttgtgt tcaaattttg gattctgtta   1800

aatttagcca gcttgtgagt tcttgtcgaa aagtatttta aaccaattta cactatttat   1860

gggtatttgt gaaaagctat atagtgatat tttatatata actaatttaa aatattttta   1920

ttttatgtaa caaaaatact ataggctaag ctatttcttc ttattttttt atgaatactt   1980

gctgaattgc catagggcac aaagactctt ctgtttgcat atcttctcag gaaattaaaa   2040

ttgtatcaca tgtatttata agaa                                          2064


<210>  5
<211>  1261
<212>  DNA
<213>  Mus musculus

<400>  5
acttgtgggt atctgctttc cccagttctc attccatcag agaacgagtt ctagcctcat     60

ggaggaaatg cctttgagag agtcaagtcc tcaaagggca gagaggtgca agaagtcatg    120

gctcttgtgc atagtggctc tgttactgat gctgctctgt tctttgggta cactgatcta    180

tacttcactc aagccaactg ccatcgagtc ctgcatggtt aagtttgaac tatcatcctc    240

aaaatggcac atgacatctc ccaaacctca ctgtgtgaat acgacatctg atgggaagct    300

gaagatactg cagagtggca catatttaat ctacggccaa gtgattcctg tggataagaa    360

atacataaaa gacaatgccc ccttcgtagt acagatatat aaaaagaatg atgtcctaca    420

aactctaatg aatgattttc aaatcttgcc tataggaggg gtttatgaac tgcatgctgg    480

agataacata tatctgaagt tcaactctaa agaccatatt cagaaaaata acacatactg    540

ggggatcatc ttaatgcctg atctaccatt catctcttag agattgggtt tggtctcctc    600

atcttcttct ttgtatccca ccctctctgt gtatgtgtta tgttgtttgt atgtattgca    660

tgcaattatt taggtgtgca catgtatgtg ttgtgcgaga gcctgtgcaa gtgtgtatgt    720

gcttgtgggt gtggcactga gtgtcttcct tagttcctct accccttaat ctttgagacg    780

tggtgatctc tccctgaacc cagagttcat ctatttggct tggcctgccc accatttggc    840

tctaaggatc tagctattgc tgctcaccag ccacagttct cagattacag gtgtgtgccg    900

ctatgcctgg atatcacatg gattttggag atctaaactt aggtccttat acttacatag    960

caggcatgct atccacagag ttatttctgg aacttaatga tgtcattctg tccctgtctt   1020

attcttagga caatcaaggc agatagaaaa cgaaaaaaat gatattgcca catacccagc   1080

aaaggcccaa cagaattgtg attttttttt aagtaccagt gggattcaga cagagggata   1140

gctagcaaca tatagcatct gaatttcttc caatgttatc atttcagctt ttgcgttcaa   1200

tgtatactca actctttttc tctattttaa aactacaata aaatatgtat ttataattgt   1260

a                                                                   1261


<210>  6
<211>  12
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic peptide

<400>  6

Gly Phe Ser Leu Ser Thr Ser Gly Met Gly Val Gly 
1               5                   10          


<210>  7
<211>  16
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic peptide

<400>  7

His Ile Trp Trp Asp Asp Asp Lys Tyr Tyr Asn Pro Ser Leu Lys Ser 
1               5                   10                  15      


<210>  8
<211>  16
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic peptide

<400>  8

His Ile Trp Trp Asp Asp Asp Lys Tyr Tyr Gln Pro Ser Leu Lys Ser 
1               5                   10                  15      


<210>  9
<211>  9
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic peptide

<400>  9

Thr Arg Arg Tyr Phe Pro Phe Ala Tyr 
1               5                   


<210>  10
<211>  11
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic peptide

<400>  10

Lys Ala Ser Gln Asn Val Gly Thr Asn Val Ala 
1               5                   10      


<210>  11
<211>  7
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic peptide

<400>  11

Ser Ala Ser Tyr Arg Tyr Ser 
1               5           


<210>  12
<211>  9
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic peptide

<400>  12

Gln Gln Tyr Asn Thr Asp Pro Leu Thr 
1               5                   


