                         SEQUENCE LISTING

<110>  EXTERNAUTICS S.P.A.
 
<120>  LUNG TUMOR MARKERS AND METHODS OF USE THEREOF

<130>  1299PCT

<160>  100   

<170>  PatentIn version 3.3

<210>  1
<211>  157
<212>  PRT
<213>  Homo sapiens

<400>  1

Met Leu Pro Glu Gln Gly Pro Gln Pro Ser Thr Met Pro Leu Trp Cys 
1               5                   10                  15      


Leu Leu Ala Ala Cys Thr Ser Leu Pro Arg Gln Ala Ala Thr Met Leu 
            20                  25                  30          


Glu Glu Ala Ala Ser Pro Asn Glu Ala Val His Ala Ser Thr Ser Gly 
        35                  40                  45              


Ser Gly Ala Leu Thr Asp Gln Thr Phe Thr Asp Leu Ser Ala Ala Glu 
    50                  55                  60                  


Ala Ser Ser Glu Glu Val Pro Asp Phe Met Glu Val Pro His Ser Val 
65                  70                  75                  80  


His His Lys Ile Asn Cys Phe Phe Tyr Leu Glu Lys Gln Leu Cys Gln 
                85                  90                  95      


Leu Pro Ser Pro Leu Cys Leu Ser Ser Leu Leu Thr Leu Lys Leu Lys 
            100                 105                 110         


Thr Thr Val Pro Ala Pro Gly Arg Trp Trp Ser Phe Gln Pro His Lys 
        115                 120                 125             


Ala Phe Pro Leu Leu Val Gly Thr Pro Gly Ser Trp Gln Ser Thr Ile 
    130                 135                 140                 


Asp Pro Ala Trp Ala Ala Pro Ser Gln Pro Ser Pro Gly 
145                 150                 155         


<210>  2
<211>  474
<212>  DNA
<213>  Homo sapiens

<400>  2
atgcttccag agcaagggcc ccagccttcc acgatgccgc tctggtgcct cctcgccgcc     60

tgcaccagcc tcccaaggca ggcagccacc atgctggagg aagctgcttc tcccaacgag    120

gctgtccacg catcaacatc aggcagtggc gcactcactg atcagacatt tacagacctc    180

tcagctgccg aggcctcctc agaggaggtt cctgacttca tggaggtgcc acactctgtt    240

caccataaaa ttaactgctt tttctactta gaaaaacaac tctgccaact gccgtcccca    300

ctgtgtctaa gcagcttgct tactttaaaa ttaaaaacaa cggtcccagc tcctggcagg    360

tggtggagct tccagcctca caaggcattc ccacttctgg tgggcactcc tggaagctgg    420

cagagcacaa tcgatcccgc gtgggcggcc ccctctcagc caagcccagg gtga          474


<210>  3
<211>  147
<212>  PRT
<213>  Homo sapiens

<400>  3

Met Gly Phe Ile Phe Ser Lys Ser Met Asn Glu Ser Met Lys Asn Gln 
1               5                   10                  15      


Lys Glu Phe Met Leu Met Asn Ala Arg Leu Gln Leu Glu Arg Gln Leu 
            20                  25                  30          


Ile Met Gln Ser Glu Met Arg Glu Arg Gln Met Ala Met Gln Ile Ala 
        35                  40                  45              


Trp Ser Arg Glu Phe Leu Lys Tyr Phe Gly Thr Phe Phe Gly Leu Ala 
    50                  55                  60                  


Ala Ile Ser Leu Thr Ala Gly Ala Ile Lys Lys Lys Lys Pro Ala Phe 
65                  70                  75                  80  


Leu Val Pro Ile Val Pro Leu Ser Phe Ile Leu Thr Tyr Gln Tyr Asp 
                85                  90                  95      


Leu Gly Tyr Gly Thr Leu Leu Glu Arg Met Lys Gly Glu Ala Glu Asp 
            100                 105                 110         


Ile Leu Glu Thr Glu Lys Ser Lys Leu Gln Leu Pro Arg Gly Met Ile 
        115                 120                 125             


Thr Phe Glu Ser Ile Glu Lys Ala Arg Lys Glu Gln Ser Arg Phe Phe 
    130                 135                 140                 


Ile Asp Lys 
145         


<210>  4
<211>  932
<212>  DNA
<213>  Homo sapiens

<400>  4
gagcgaggcc cggtccctgc agcgggcgaa aggagcccgg gcctggaggt ttgcgtaccg     60

gtcgcctggt cccggcacca gcgccgccca gtgtggtttc ccataaggaa gctcttcttc    120

ctgcttggct tccaccttta acccttccac ctgggagcgt cctctaacac attcagacta    180

caagtccaga cccaggagag caaggcccag aaagaggtca aaatggggtt tatattttca    240

aaatctatga atgaaagcat gaaaaatcaa aaggagttca tgcttatgaa tgctcgactt    300

cagctggaaa ggcagctcat catgcagagt gaaatgaggg aaagacaaat ggccatgcag    360

attgcgtggt ctcgggaatt cctcaaatat tttggaactt tttttggcct tgcagccatc    420

tctttaacag ctggagcgat taaaaaaaag aagccagcct tcctggtccc gattgttcca    480

ttaagcttta tcctcaccta ccagtatgac ttgggctatg gaaccctttt agaaagaatg    540

aaaggtgaag ctgaggacat actggaaaca gaaaagagta aattgcagct gccaagagga    600

atgatcactt ttgaaagcat tgaaaaagcc agaaaggaac agagtagatt cttcatagac    660

aaatgaaatc atgcttacca atcaaatctc aaagcacaga attattgact tgaatcatgg    720

tttttacagt tttttaaatg ctcaagattt tgatattata gattttattt taaaatatta    780

aaatgcaaga tagttttgag ctattttaaa ataaaattta taacattcaa cacaaaatca    840

tggaggtgct ctaaataact tttagatttc ctctctctgt gtgcattacc aatatctaag    900

tgtaaaatta ataaattgtt ttgaattcct gg                                  932


<210>  5
<211>  543
<212>  PRT
<213>  Homo sapiens

<400>  5

Met Val Pro Arg Leu Thr Ala Val Leu Gln Thr Ala Met Ala Ala Gly 
1               5                   10                  15      


Ser Leu Gly Leu Leu Leu Pro Gly Ser His Tyr Leu Gly Arg Phe Gln 
            20                  25                  30          


Asp Arg Leu Met Trp Ile Met Ile Leu Glu Cys Gly Tyr Thr Tyr Cys 
        35                  40                  45              


Ser Ile Asn Ile Lys Gly Leu Glu Leu Gln Glu Thr Ser Cys His Thr 
    50                  55                  60                  


Ala Glu Ala Arg Arg Val Asp Glu Val Phe Glu Asp Ala Phe Glu Gln 
65                  70                  75                  80  


Glu Tyr Thr Arg Val Cys Ser Leu Asn Glu His Phe Gly Asn Val Leu 
                85                  90                  95      


Thr Pro Cys Thr Val Leu Pro Val Lys Leu Tyr Ser Asp Ala Arg Asn 
            100                 105                 110         


Val Leu Ser Gly Ile Ile Asp Ser His Glu Asn Leu Lys Glu Phe Lys 
        115                 120                 125             


Gly Asp Leu Ile Lys Val Leu Val Trp Ile Leu Val Gln Tyr Cys Ser 
    130                 135                 140                 


Lys Arg Pro Gly Met Lys Glu Asn Val His Asn Thr Glu Asn Lys Gly 
145                 150                 155                 160 


Lys Ala Pro Leu Met Leu Pro Ala Leu Asn Thr Leu Pro Pro Pro Lys 
                165                 170                 175     


Ser Pro Glu Asp Ile Asp Ser Leu Asn Ser Glu Thr Phe Asn Asp Trp 
            180                 185                 190         


Ser Asp Asp Asn Ile Phe Asp Asp Glu Pro Thr Ile Lys Lys Val Ile 
        195                 200                 205             


Glu Glu Lys His Gln Leu Lys Asp Leu Pro Gly Thr Asn Leu Phe Ile 
    210                 215                 220                 


Pro Gly Ser Val Glu Ser Gln Arg Val Gly Asp His Ser Thr Gly Thr 
225                 230                 235                 240 


Val Pro Glu Asn Asp Leu Tyr Lys Ala Val Leu Leu Gly Tyr Pro Ala 
                245                 250                 255     


Val Asp Lys Gly Lys Gln Glu Asp Met Pro Tyr Ile Pro Leu Met Glu 
            260                 265                 270         


Phe Ser Cys Ser His Ser His Leu Val Cys Leu Pro Ala Glu Trp Arg 
        275                 280                 285             


Thr Ser Cys Met Pro Ser Ser Lys Met Lys Glu Met Ser Ser Leu Phe 
    290                 295                 300                 


Pro Glu Asp Trp Tyr Gln Phe Val Leu Arg Gln Leu Glu Cys Tyr His 
305                 310                 315                 320 


Ser Glu Glu Lys Ala Ser Asn Val Leu Glu Glu Ile Ala Lys Asp Lys 
                325                 330                 335     


Val Leu Lys Asp Phe Tyr Val His Thr Val Met Thr Cys Tyr Phe Ser 
            340                 345                 350         


Leu Phe Gly Ile Asp Asn Met Ala Pro Ser Pro Gly His Ile Leu Arg 
        355                 360                 365             


Val Tyr Gly Gly Val Leu Pro Trp Ser Val Ala Leu Asp Trp Leu Thr 
    370                 375                 380                 


Glu Lys Pro Glu Leu Phe Gln Leu Ala Leu Lys Ala Phe Arg Tyr Thr 
385                 390                 395                 400 


Leu Lys Leu Met Ile Asp Lys Ala Ser Leu Gly Pro Ile Glu Asp Phe 
                405                 410                 415     


Arg Glu Leu Ile Lys Tyr Leu Glu Glu Tyr Glu Arg Asp Trp Tyr Ile 
            420                 425                 430         


Gly Leu Val Ser Asp Glu Lys Trp Lys Glu Ala Ile Leu Gln Glu Lys 
        435                 440                 445             


Pro Tyr Leu Phe Ser Leu Gly Tyr Asp Ser Asn Met Gly Ile Tyr Thr 
    450                 455                 460                 


Gly Arg Val Leu Ser Leu Gln Glu Leu Leu Ile Gln Val Gly Lys Leu 
465                 470                 475                 480 


Asn Pro Glu Ala Val Arg Gly Gln Trp Ala Asn Leu Ser Trp Glu Leu 
                485                 490                 495     


Leu Tyr Ala Thr Asn Asp Asp Glu Glu Arg Tyr Ser Ile Gln Ala His 
            500                 505                 510         


Pro Leu Leu Leu Arg Asn Leu Thr Val Gln Ala Ala Glu Pro Pro Leu 
        515                 520                 525             


Gly Tyr Pro Ile Tyr Ser Ser Lys Pro Leu His Ile His Leu Tyr 
    530                 535                 540             


<210>  6
<211>  938
<212>  PRT
<213>  Homo sapiens

<400>  6

Met Pro Ala Leu Glu His Met Asn Gln Ile Leu His Ile Leu Phe Val 
1               5                   10                  15      


Phe Leu Pro Phe Leu Trp Ala Leu Gly Thr Leu Pro Pro Pro Asp Ala 
            20                  25                  30          


Leu Leu Leu Trp Ala Met Glu Gln Val Leu Glu Phe Gly Leu Gly Gly 
        35                  40                  45              


Ser Ser Met Ser Thr His Leu Arg Leu Leu Val Met Phe Ile Met Ser 
    50                  55                  60                  


Ala Gly Thr Ala Ile Ala Ser Tyr Phe Ile Pro Ser Thr Val Gly Val 
65                  70                  75                  80  


Val Leu Phe Met Thr Gly Phe Gly Phe Leu Leu Ser Leu Asn Leu Ser 
                85                  90                  95      


Asp Met Gly His Lys Ile Gly Thr Lys Ser Lys Asp Leu Pro Ser Gly 
            100                 105                 110         


Pro Glu Lys His Phe Ser Trp Lys Glu Cys Leu Phe Tyr Ile Ile Ile 
        115                 120                 125             


Leu Val Leu Ala Leu Leu Glu Thr Ser Leu Leu His His Phe Ala Gly 
    130                 135                 140                 


Phe Ser Gln Ile Ser Lys Ser Asn Ser Gln Ala Ile Val Gly Tyr Gly 
145                 150                 155                 160 


Leu Met Ile Leu Leu Ile Ile Leu Trp Ile Leu Arg Glu Ile Gln Ser 
                165                 170                 175     


Val Tyr Ile Ile Gly Ile Phe Arg Asn Pro Phe Tyr Pro Lys Asp Val 
            180                 185                 190         


Gln Thr Val Thr Val Phe Phe Glu Lys Gln Thr Arg Leu Met Lys Ile 
        195                 200                 205             


Gly Ile Val Arg Arg Ile Leu Leu Thr Leu Val Ser Pro Phe Ala Met 
    210                 215                 220                 


Ile Ala Phe Leu Ser Leu Asp Ser Ser Leu Gln Gly Leu His Ser Val 
225                 230                 235                 240 


Ser Val Cys Ile Gly Phe Thr Arg Ala Phe Arg Met Val Trp Gln Asn 
                245                 250                 255     


Thr Glu Asn Ala Leu Leu Glu Thr Val Ile Val Ser Thr Val His Leu 
            260                 265                 270         


Ile Ser Ser Thr Asp Ile Trp Trp Asn Arg Ser Leu Asp Thr Gly Leu 
        275                 280                 285             


Arg Leu Leu Leu Val Gly Ile Ile Arg Asp Arg Leu Ile Gln Phe Ile 
    290                 295                 300                 


Ser Lys Leu Gln Phe Ala Val Thr Val Leu Leu Thr Ser Trp Thr Glu 
305                 310                 315                 320 


Lys Lys Gln Arg Arg Lys Thr Thr Ala Thr Leu Cys Ile Leu Asn Ile 
                325                 330                 335     


Val Phe Ser Pro Phe Val Leu Val Ile Ile Val Phe Ser Thr Leu Leu 
            340                 345                 350         


Ser Ser Pro Leu Leu Pro Leu Phe Thr Leu Pro Val Phe Leu Val Gly 
        355                 360                 365             


Phe Pro Arg Pro Ile Gln Ser Trp Pro Gly Ala Ala Gly Thr Thr Ala 
    370                 375                 380                 


Cys Val Cys Ala Asp Thr Val Tyr Tyr Tyr Gln Met Val Pro Arg Leu 
385                 390                 395                 400 


Thr Ala Val Leu Gln Thr Ala Met Ala Ala Gly Ser Leu Gly Leu Leu 
                405                 410                 415     


Leu Pro Gly Ser His Tyr Leu Gly Arg Phe Gln Asp Arg Leu Met Trp 
            420                 425                 430         


Ile Met Ile Leu Glu Cys Gly Tyr Thr Tyr Cys Ser Ile Asn Ile Lys 
        435                 440                 445             


Gly Leu Glu Leu Gln Glu Thr Ser Cys His Thr Ala Glu Ala Arg Arg 
    450                 455                 460                 


Val Asp Glu Val Phe Glu Asp Ala Phe Glu Gln Glu Tyr Thr Arg Val 
465                 470                 475                 480 


Cys Ser Leu Asn Glu His Phe Gly Asn Val Leu Thr Pro Cys Thr Val 
                485                 490                 495     


Leu Pro Val Lys Leu Tyr Ser Asp Ala Arg Asn Val Leu Ser Gly Ile 
            500                 505                 510         


Ile Asp Ser His Glu Asn Leu Lys Glu Phe Lys Gly Asp Leu Ile Lys 
        515                 520                 525             


Val Leu Val Trp Ile Leu Val Gln Tyr Cys Ser Lys Arg Pro Gly Met 
    530                 535                 540                 


Lys Glu Asn Val His Asn Thr Glu Asn Lys Gly Lys Ala Pro Leu Met 
545                 550                 555                 560 


Leu Pro Ala Leu Asn Thr Leu Pro Pro Pro Lys Ser Pro Glu Asp Ile 
                565                 570                 575     


Asp Ser Leu Asn Ser Glu Thr Phe Asn Asp Trp Ser Asp Asp Asn Ile 
            580                 585                 590         


Phe Asp Asp Glu Pro Thr Ile Lys Lys Val Ile Glu Glu Lys His Gln 
        595                 600                 605             


Leu Lys Asp Leu Pro Gly Thr Asn Leu Phe Ile Pro Gly Ser Val Glu 
    610                 615                 620                 


Ser Gln Arg Val Gly Asp His Ser Thr Gly Thr Val Pro Glu Asn Asp 
625                 630                 635                 640 


Leu Tyr Lys Ala Val Leu Leu Gly Tyr Pro Ala Val Asp Lys Gly Lys 
                645                 650                 655     


Gln Glu Asp Met Pro Tyr Ile Pro Leu Met Glu Phe Ser Cys Ser His 
            660                 665                 670         


Ser His Leu Val Cys Leu Pro Ala Glu Trp Arg Thr Ser Cys Met Pro 
        675                 680                 685             


Ser Ser Lys Met Lys Glu Met Ser Ser Leu Phe Pro Glu Asp Trp Tyr 
    690                 695                 700                 


Gln Phe Val Leu Arg Gln Leu Glu Cys Tyr His Ser Glu Glu Lys Ala 
705                 710                 715                 720 


Ser Asn Val Leu Glu Glu Ile Ala Lys Asp Lys Val Leu Lys Asp Phe 
                725                 730                 735     


Tyr Val His Thr Val Met Thr Cys Tyr Phe Ser Leu Phe Gly Ile Asp 
            740                 745                 750         


Asn Met Ala Pro Ser Pro Gly His Ile Leu Arg Val Tyr Gly Gly Val 
        755                 760                 765             


Leu Pro Trp Ser Val Ala Leu Asp Trp Leu Thr Glu Lys Pro Glu Leu 
    770                 775                 780                 


Phe Gln Leu Ala Leu Lys Ala Phe Arg Tyr Thr Leu Lys Leu Met Ile 
785                 790                 795                 800 


Asp Lys Ala Ser Leu Gly Pro Ile Glu Asp Phe Arg Glu Leu Ile Lys 
                805                 810                 815     


Tyr Leu Glu Glu Tyr Glu Arg Asp Trp Tyr Ile Gly Leu Val Ser Asp 
            820                 825                 830         


Glu Lys Trp Lys Glu Ala Ile Leu Gln Glu Lys Pro Tyr Leu Phe Ser 
        835                 840                 845             


Leu Gly Tyr Asp Ser Asn Met Gly Ile Tyr Thr Gly Arg Val Leu Ser 
    850                 855                 860                 


Leu Gln Glu Leu Leu Ile Gln Val Gly Lys Leu Asn Pro Glu Ala Val 
865                 870                 875                 880 


Arg Gly Gln Trp Ala Asn Leu Ser Trp Glu Leu Leu Tyr Ala Thr Asn 
                885                 890                 895     


Asp Asp Glu Glu Arg Tyr Ser Ile Gln Ala His Pro Leu Leu Leu Arg 
            900                 905                 910         


Asn Leu Thr Val Gln Ala Ala Glu Pro Pro Leu Gly Tyr Pro Ile Tyr 
        915                 920                 925             


Ser Ser Lys Pro Leu His Ile His Leu Tyr 
    930                 935             


<210>  7
<211>  230
<212>  PRT
<213>  Homo sapiens

<400>  7

Met Ser Pro Asp Val Pro Leu Leu Asn Asp Tyr Lys Gln Asp Phe Phe 
1               5                   10                  15      


Leu Lys Arg Phe Pro Gln Thr Val Leu Gly Gly Pro Arg Phe Lys Leu 
            20                  25                  30          


Gly Tyr Cys Ala Pro Pro Tyr Ile Tyr Val Asn Gln Ile Ile Leu Phe 
        35                  40                  45              


Leu Met Pro Trp Val Trp Gly Gly Val Gly Thr Leu Leu Tyr Gln Leu 
    50                  55                  60                  


Gly Ile Leu Lys Asp Tyr Tyr Thr Ala Ala Leu Ser Gly Gly Leu Met 
65                  70                  75                  80  


Leu Phe Thr Ala Phe Val Ile Gln Phe Thr Ser Leu Tyr Ala Lys Asn 
                85                  90                  95      


Lys Ser Thr Thr Val Glu Arg Ile Leu Thr Thr Asp Ile Leu Ala Glu 
            100                 105                 110         


Glu Asp Glu His Glu Phe Thr Ser Cys Thr Gly Ala Glu Thr Val Lys 
        115                 120                 125             


Phe Leu Ile Pro Gly Lys Lys Tyr Val Ala Asn Thr Val Phe His Ser 
    130                 135                 140                 


Ile Leu Ala Gly Leu Ala Cys Gly Leu Gly Thr Trp Tyr Leu Leu Pro 
145                 150                 155                 160 


Asn Arg Ile Thr Leu Leu Tyr Gly Ser Thr Gly Gly Thr Ala Leu Leu 
                165                 170                 175     


Phe Phe Phe Gly Trp Met Thr Leu Cys Ile Ala Glu Tyr Ser Leu Ile 
            180                 185                 190         


Val Asn Thr Ala Thr Glu Thr Ala Thr Phe Gln Thr Gln Asp Thr Tyr 
        195                 200                 205             


Glu Ile Ile Pro Leu Met Arg Pro Leu Tyr Ile Phe Phe Phe Val Ser 
    210                 215                 220                 


Val Asp Leu Ala His Arg 
225                 230 


<210>  8
<211>  1172
<212>  PRT
<213>  Homo sapiens

<400>  8

Met Ser Pro Asp Val Pro Leu Leu Asn Asp Tyr Lys Gln Asp Phe Phe 
1               5                   10                  15      


Leu Lys Arg Phe Pro Gln Thr Val Leu Gly Gly Pro Arg Phe Lys Leu 
            20                  25                  30          


Gly Tyr Cys Ala Pro Pro Tyr Ile Tyr Val Asn Gln Ile Ile Leu Phe 
        35                  40                  45              


Leu Met Pro Trp Val Trp Gly Gly Val Gly Thr Leu Leu Tyr Gln Leu 
    50                  55                  60                  


Gly Ile Leu Lys Asp Tyr Tyr Thr Ala Ala Leu Ser Gly Gly Leu Met 
65                  70                  75                  80  


Leu Phe Thr Ala Phe Val Ile Gln Phe Thr Ser Leu Tyr Ala Lys Asn 
                85                  90                  95      


Lys Ser Thr Thr Val Glu Arg Ile Leu Thr Thr Asp Ile Leu Ala Glu 
            100                 105                 110         


Glu Asp Glu His Glu Phe Thr Ser Cys Thr Gly Ala Glu Thr Val Lys 
        115                 120                 125             


Phe Leu Ile Pro Gly Lys Lys Tyr Val Ala Asn Thr Val Phe His Ser 
    130                 135                 140                 


Ile Leu Ala Gly Leu Ala Cys Gly Leu Gly Thr Trp Tyr Leu Leu Pro 
145                 150                 155                 160 


Asn Arg Ile Thr Leu Leu Tyr Gly Ser Thr Gly Gly Thr Ala Leu Leu 
                165                 170                 175     


Phe Phe Phe Gly Trp Met Thr Leu Cys Ile Ala Glu Tyr Ser Leu Ile 
            180                 185                 190         


Val Asn Thr Ala Thr Glu Thr Ala Thr Phe Gln Thr Gln Asp Thr Tyr 
        195                 200                 205             


Glu Ile Ile Pro Leu Met Arg Pro Leu Tyr Ile Phe Phe Phe Val Ser 
    210                 215                 220                 


Val Asp Leu Ala His Arg Phe Val Val Asn Met Pro Ala Leu Glu His 
225                 230                 235                 240 


Met Asn Gln Ile Leu His Ile Leu Phe Val Phe Leu Pro Phe Leu Trp 
                245                 250                 255     


Ala Leu Gly Thr Leu Pro Pro Pro Asp Ala Leu Leu Leu Trp Ala Met 
            260                 265                 270         


Glu Gln Val Leu Glu Phe Gly Leu Gly Gly Ser Ser Met Ser Thr His 
        275                 280                 285             


Leu Arg Leu Leu Val Met Phe Ile Met Ser Ala Gly Thr Ala Ile Ala 
    290                 295                 300                 


Ser Tyr Phe Ile Pro Ser Thr Val Gly Val Val Leu Phe Met Thr Gly 
305                 310                 315                 320 


Phe Gly Phe Leu Leu Ser Leu Asn Leu Ser Asp Met Gly His Lys Ile 
                325                 330                 335     


Gly Thr Lys Ser Lys Asp Leu Pro Ser Gly Pro Glu Lys His Phe Ser 
            340                 345                 350         


Trp Lys Glu Cys Leu Phe Tyr Ile Ile Ile Leu Val Leu Ala Leu Leu 
        355                 360                 365             


Glu Thr Ser Leu Leu His His Phe Ala Gly Phe Ser Gln Ile Ser Lys 
    370                 375                 380                 


Ser Asn Ser Gln Ala Ile Val Gly Tyr Gly Leu Met Ile Leu Leu Ile 
385                 390                 395                 400 


Ile Leu Trp Ile Leu Arg Glu Ile Gln Ser Val Tyr Ile Ile Gly Ile 
                405                 410                 415     


Phe Arg Asn Pro Phe Tyr Pro Lys Asp Val Gln Thr Val Thr Val Phe 
            420                 425                 430         


Phe Glu Lys Gln Thr Arg Leu Met Lys Ile Gly Ile Val Arg Arg Ile 
        435                 440                 445             


Leu Leu Thr Leu Val Ser Pro Phe Ala Met Ile Ala Phe Leu Ser Leu 
    450                 455                 460                 


Asp Ser Ser Leu Gln Gly Leu His Ser Val Ser Val Cys Ile Gly Phe 
465                 470                 475                 480 


Thr Arg Ala Phe Arg Met Val Trp Gln Asn Thr Glu Asn Ala Leu Leu 
                485                 490                 495     


Glu Thr Val Ile Val Ser Thr Val His Leu Ile Ser Ser Thr Asp Ile 
            500                 505                 510         


Trp Trp Asn Arg Ser Leu Asp Thr Gly Leu Arg Leu Leu Leu Val Gly 
        515                 520                 525             


Ile Ile Arg Asp Arg Leu Ile Gln Phe Ile Ser Lys Leu Gln Phe Ala 
    530                 535                 540                 


Val Thr Val Leu Leu Thr Ser Trp Thr Glu Lys Lys Gln Arg Arg Lys 
545                 550                 555                 560 


Thr Thr Ala Thr Leu Cys Ile Leu Asn Ile Val Phe Ser Pro Phe Val 
                565                 570                 575     


Leu Val Ile Ile Val Phe Ser Thr Leu Leu Ser Ser Pro Leu Leu Pro 
            580                 585                 590         


Leu Phe Thr Leu Pro Val Phe Leu Val Gly Phe Pro Arg Pro Ile Gln 
        595                 600                 605             


Ser Trp Pro Gly Ala Ala Gly Thr Thr Ala Cys Val Cys Ala Asp Thr 
    610                 615                 620                 


Val Tyr Tyr Tyr Gln Met Val Pro Arg Leu Thr Ala Val Leu Gln Thr 
625                 630                 635                 640 


Ala Met Ala Ala Gly Ser Leu Gly Leu Leu Leu Pro Gly Ser His Tyr 
                645                 650                 655     


Leu Gly Arg Phe Gln Asp Arg Leu Met Trp Ile Met Ile Leu Glu Cys 
            660                 665                 670         


Gly Tyr Thr Tyr Cys Ser Ile Asn Ile Lys Gly Leu Glu Leu Gln Glu 
        675                 680                 685             


Thr Ser Cys His Thr Ala Glu Ala Arg Arg Val Asp Glu Val Phe Glu 
    690                 695                 700                 


Asp Ala Phe Glu Gln Glu Tyr Thr Arg Val Cys Ser Leu Asn Glu His 
705                 710                 715                 720 


Phe Gly Asn Val Leu Thr Pro Cys Thr Val Leu Pro Val Lys Leu Tyr 
                725                 730                 735     


Ser Asp Ala Arg Asn Val Leu Ser Gly Ile Ile Asp Ser His Glu Asn 
            740                 745                 750         


Leu Lys Glu Phe Lys Gly Asp Leu Ile Lys Val Leu Val Trp Ile Leu 
        755                 760                 765             


Val Gln Tyr Cys Ser Lys Arg Pro Gly Met Lys Glu Asn Val His Asn 
    770                 775                 780                 


Thr Glu Asn Lys Gly Lys Ala Pro Leu Met Leu Pro Ala Leu Asn Thr 
785                 790                 795                 800 


Leu Pro Pro Pro Lys Ser Pro Glu Asp Ile Asp Ser Leu Asn Ser Glu 
                805                 810                 815     


Thr Phe Asn Asp Trp Ser Asp Asp Asn Ile Phe Asp Asp Glu Pro Thr 
            820                 825                 830         


Ile Lys Lys Val Ile Glu Glu Lys His Gln Leu Lys Asp Leu Pro Gly 
        835                 840                 845             


Thr Asn Leu Phe Ile Pro Gly Ser Val Glu Ser Gln Arg Val Gly Asp 
    850                 855                 860                 


His Ser Thr Gly Thr Val Pro Glu Asn Asp Leu Tyr Lys Ala Val Leu 
865                 870                 875                 880 


Leu Gly Tyr Pro Ala Val Asp Lys Gly Lys Gln Glu Asp Met Pro Tyr 
                885                 890                 895     


Ile Pro Leu Met Glu Phe Ser Cys Ser His Ser His Leu Val Cys Leu 
            900                 905                 910         


Pro Ala Glu Trp Arg Thr Ser Cys Met Pro Ser Ser Lys Met Lys Glu 
        915                 920                 925             


Met Ser Ser Leu Phe Pro Glu Asp Trp Tyr Gln Phe Val Leu Arg Gln 
    930                 935                 940                 


Leu Glu Cys Tyr His Ser Glu Glu Lys Ala Ser Asn Val Leu Glu Glu 
945                 950                 955                 960 


Ile Ala Lys Asp Lys Val Leu Lys Asp Phe Tyr Val His Thr Val Met 
                965                 970                 975     


Thr Cys Tyr Phe Ser Leu Phe Gly Ile Asp Asn Met Ala Pro Ser Pro 
            980                 985                 990         


Gly His Ile Leu Arg Val Tyr Gly  Gly Val Leu Pro Trp  Ser Val Ala 
        995                 1000                 1005             


Leu Asp  Trp Leu Thr Glu Lys  Pro Glu Leu Phe Gln  Leu Ala Leu 
    1010                 1015                 1020             


Lys Ala  Phe Arg Tyr Thr Leu  Lys Leu Met Ile Asp  Lys Ala Ser 
    1025                 1030                 1035             


Leu Gly  Pro Ile Glu Asp Phe  Arg Glu Leu Ile Lys  Tyr Leu Glu 
    1040                 1045                 1050             


Glu Tyr  Glu Arg Asp Trp Tyr  Ile Gly Leu Val Ser  Asp Glu Lys 
    1055                 1060                 1065             


Trp Lys  Glu Ala Ile Leu Gln  Glu Lys Pro Tyr Leu  Phe Ser Leu 
    1070                 1075                 1080             


Gly Tyr  Asp Ser Asn Met Gly  Ile Tyr Thr Gly Arg  Val Leu Ser 
    1085                 1090                 1095             


Leu Gln  Glu Leu Leu Ile Gln  Val Gly Lys Leu Asn  Pro Glu Ala 
    1100                 1105                 1110             


Val Arg  Gly Gln Trp Ala Asn  Leu Ser Trp Glu Leu  Leu Tyr Ala 
    1115                 1120                 1125             


Thr Asn  Asp Asp Glu Glu Arg  Tyr Ser Ile Gln Ala  His Pro Leu 
    1130                 1135                 1140             


Leu Leu  Arg Asn Leu Thr Val  Gln Ala Ala Glu Pro  Pro Leu Gly 
    1145                 1150                 1155             


Tyr Pro  Ile Tyr Ser Ser Lys  Pro Leu His Ile His  Leu Tyr 
    1160                 1165                 1170         


<210>  9
<211>  873
<212>  PRT
<213>  Homo sapiens

<400>  9

Met Pro Ala Leu Glu His Met Asn Gln Ile Leu His Ile Leu Phe Val 
1               5                   10                  15      


Phe Leu Pro Phe Leu Trp Ala Leu Gly Thr Leu Pro Pro Pro Asp Ala 
            20                  25                  30          


Leu Leu Leu Trp Ala Met Glu Gln Val Leu Glu Phe Gly Leu Gly Gly 
        35                  40                  45              


Ser Ser Met Ser Thr His Leu Arg Leu Leu Val Met Phe Ile Met Ser 
    50                  55                  60                  


Ala Gly Thr Ala Ile Ala Ser Tyr Phe Ile Pro Ser Thr Val Gly Val 
65                  70                  75                  80  


Val Leu Phe Met Thr Gly Phe Gly Phe Leu Leu Ser Leu Asn Leu Ser 
                85                  90                  95      


Asp Met Gly His Lys Ile Gly Thr Lys Ser Lys Asp Leu Pro Ser Gly 
            100                 105                 110         


Pro Glu Lys His Phe Ser Trp Lys Glu Cys Leu Phe Tyr Ile Ile Ile 
        115                 120                 125             


Leu Val Leu Ala Leu Leu Glu Thr Ser Leu Leu His His Phe Ala Gly 
    130                 135                 140                 


Phe Ser Gln Ile Ser Lys Ser Asn Ser Gln Ala Ile Val Gly Tyr Gly 
145                 150                 155                 160 


Leu Met Ile Leu Leu Ile Ile Leu Trp Ile Leu Arg Glu Ile Gln Ser 
                165                 170                 175     


Val Tyr Ile Ile Gly Ile Phe Arg Asn Pro Phe Tyr Pro Lys Asp Val 
            180                 185                 190         


Gln Thr Val Thr Val Phe Phe Glu Lys Gln Thr Arg Leu Met Lys Ile 
        195                 200                 205             


Gly Ile Val Arg Arg Ile Leu Leu Thr Leu Val Ser Pro Phe Ala Met 
    210                 215                 220                 


Ile Ala Phe Leu Ser Leu Asp Ser Ser Leu Gln Gly Leu His Ser Val 
225                 230                 235                 240 


Ser Val Cys Ile Gly Phe Thr Arg Ala Phe Arg Met Val Trp Gln Asn 
                245                 250                 255     


Thr Glu Asn Ala Leu Leu Glu Thr Val Ile Val Ser Thr Val His Leu 
            260                 265                 270         


Ile Ser Ser Thr Asp Ile Trp Trp Asn Arg Ser Leu Asp Thr Gly Leu 
        275                 280                 285             


Arg Leu Leu Leu Val Gly Ile Ile Arg Asp Arg Leu Ile Gln Phe Ile 
    290                 295                 300                 


Ser Lys Leu Gln Phe Ala Val Thr Val Leu Leu Thr Ser Trp Thr Glu 
305                 310                 315                 320 


Lys Lys Gln Arg Arg Lys Thr Thr Ala Thr Leu Cys Ile Leu Asn Ile 
                325                 330                 335     


Val Phe Ser Pro Phe Val Leu Val Ile Ile Val Phe Ser Thr Leu Leu 
            340                 345                 350         


Ser Ser Pro Leu Leu Pro Leu Phe Thr Leu Pro Val Phe Leu Val Gly 
        355                 360                 365             


Phe Pro Arg Pro Ile Gln Ser Trp Pro Gly Ala Ala Gly Thr Thr Ala 
    370                 375                 380                 


Cys Val Cys Ala Asp Thr Val Tyr Tyr Tyr Gln Met Val Pro Arg Leu 
385                 390                 395                 400 


Thr Ala Val Leu Gln Thr Ala Met Ala Ala Gly Ser Leu Gly Leu Leu 
                405                 410                 415     


Leu Pro Gly Ser His Tyr Leu Gly Arg Phe Gln Asp Arg Leu Met Trp 
            420                 425                 430         


Ile Met Ile Leu Glu Cys Gly Tyr Thr Tyr Cys Ser Ile Asn Ile Lys 
        435                 440                 445             


Gly Leu Glu Leu Gln Glu Thr Ser Cys His Thr Ala Glu Ala Arg Arg 
    450                 455                 460                 


Val Asp Glu Val Phe Glu Asp Ala Phe Glu Gln Glu Tyr Thr Arg Val 
465                 470                 475                 480 


Cys Ser Leu Asn Glu His Phe Gly Asn Val Leu Thr Pro Cys Thr Val 
                485                 490                 495     


Leu Pro Val Lys Leu Tyr Ser Asp Ala Arg Asn Val Leu Ser Gly Ile 
            500                 505                 510         


Ile Asp Ser His Glu Asn Leu Lys Glu Phe Lys Gly Asp Leu Ile Lys 
        515                 520                 525             


Val Leu Val Trp Ile Leu Val Gln Tyr Cys Ser Lys Arg Pro Gly Met 
    530                 535                 540                 


Lys Glu Asn Val His Asn Thr Glu Asn Lys Gly Lys Ala Pro Leu Met 
545                 550                 555                 560 


Leu Pro Ala Leu Asn Thr Leu Pro Pro Pro Lys Ser Pro Glu Asp Ile 
                565                 570                 575     


Asp Ser Leu Asn Ser Glu Thr Phe Asn Asp Trp Ser Asp Asp Asn Ile 
            580                 585                 590         


Phe Asp Asp Glu Pro Thr Ile Lys Lys Val Ile Glu Glu Lys His Gln 
        595                 600                 605             


Leu Lys Asp Leu Pro Gly Thr Asn Leu Phe Ile Pro Gly Ser Val Glu 
    610                 615                 620                 


Ser Gln Arg Val Gly Asp His Ser Thr Gly Thr Val Pro Glu Asn Asp 
625                 630                 635                 640 


Leu Tyr Lys Ala Val Leu Leu Gly Tyr Pro Ala Val Asp Lys Gly Lys 
                645                 650                 655     


Gln Glu Asp Met Pro Tyr Ile Pro Leu Met Glu Phe Ser Cys Ser His 
            660                 665                 670         


Ser His Leu Val Cys Leu Pro Ala Glu Trp Arg Thr Ser Cys Met Pro 
        675                 680                 685             


Ser Ser Lys Met Lys Glu Met Ser Ser Leu Phe Pro Glu Asp Trp Tyr 
    690                 695                 700                 


Gln Phe Val Leu Arg Gln Leu Glu Cys Tyr His Ser Glu Glu Lys Ala 
705                 710                 715                 720 


Ser Asn Val Leu Glu Glu Ile Ala Lys Asp Lys Val Leu Lys Asp Phe 
                725                 730                 735     


Tyr Val His Thr Val Met Thr Cys Tyr Phe Ser Leu Phe Gly Ile Asp 
            740                 745                 750         


Asn Met Ala Pro Ser Pro Gly His Ile Leu Arg Val Tyr Gly Gly Val 
        755                 760                 765             


Leu Pro Trp Ser Val Ala Leu Asp Trp Leu Thr Glu Lys Pro Glu Leu 
    770                 775                 780                 


Phe Gln Leu Ala Leu Lys Ala Phe Arg Tyr Thr Leu Lys Leu Met Ile 
785                 790                 795                 800 


Asp Lys Ala Ser Leu Gly Pro Ile Glu Asp Phe Arg Glu Leu Ile Lys 
                805                 810                 815     


Tyr Leu Glu Glu Tyr Glu Arg Asp Trp Tyr Ile Gly Leu Val Ser Asp 
            820                 825                 830         


Glu Lys Trp Lys Glu Ala Ile Leu Gln Glu Lys Pro Tyr Leu Phe Ser 
        835                 840                 845             


Leu Gly Tyr Asp Ser Asn Met Pro Gly Pro Ala Leu Glu Ile Ser Arg 
    850                 855                 860                 


Val Asn Arg Asn Leu Trp Ser Gln Ile 
865                 870             


<210>  10
<211>  3927
<212>  DNA
<213>  Homo sapiens

<400>  10
aacgacgctc ttgcgtaaag gcccggccca agggaacgtt cagggcgtct cggctttccc     60

cgctgctgct tctgctaggc ccagtgcgag accagagcac gagcgactcc cgtcgtcccc    120

ggccaggcag atgttggcct agtcctggcg cgaacgaagc gcgctatttc cctgcttcct    180

ctaggccaag cctgctttac ggcagggccc gcctcgggag cgagcacaga ccggggcagc    240

gaggccagcc aggcgccgac gaggtccccg aacgcgcacg cgctccgttc agctccgggt    300

ggcggccgcc ggagtagacg ttagccatgg aaaccgagag ctggcccggg cggggccgcg    360

gtgagctcgt tattcggccg ccgcagcttt tctgcctccg cattcgggca ctaaccaacc    420

tcccggcggg agcgcccagc ccgagtttac ctgcaaaaat gcggtccctg ggatgccttc    480

gcgtcttctc ttccctcggg tgacttgagg tttgtggtaa atatgccagc tctagaacac    540

atgaatcaga ttttacacat cttgtttgta tttttaccct ttctgtgggc acttgggact    600

ctgcccccac ccgatgcact tctcttatgg gcaatggagc aggttttaga gttcggcctt    660

ggaggctcat ctatgtcaac ccacttacgg ttattagtaa tgttcatcat gtctgctgga    720

acagctatag catcatattt cattccaagc actgttggtg tggttctttt catgactgga    780

tttggtttct tgctgagtct gaacttaagt gatatgggtc acaaaattgg aaccaaatct    840

aaggatttac ccagtggtcc ggaaaaacat ttttcatgga aggaatgcct tttctacatc    900

attatattag tcttggctct tttagaaact agcttgcttc atcactttgc tggcttctca    960

cagatttcta aaagcaattc ccaggctatt gtgggctatg gtttgatgat attacttata   1020

atactgtgga tacttagaga aattcaaagc gtatatatca ttggaatttt ccgaaatccc   1080

ttttatccga aggatgtgca aactgtgact gtattctttg agaagcaaac taggctcatg   1140

aagattggta ttgtcagacg gattttgcta actttagtat caccttttgc catgatagca   1200

tttctttcat tggacagttc cttacaaggg ctccactcag tgtctgtctg tattggattc   1260

acaagagcct ttagaatggt atggcagaat acagaaaatg ctttattgga gacagtcatt   1320

gtatcaacag tacacttgat ctccagtaca gacatatggt ggaacagaag cctggataca   1380

ggactcagac tcttactggt tggtatcata cgtgatcgtt tgattcagtt catctctaaa   1440

ttgcagtttg ccgtgactgt gcttttgaca tcatggacag agaaaaaaca acgtcgaaaa   1500

acaactgcca ctttatgtat actcaacatt gtcttttctc cattcgtgtt ggtcatcata   1560

gttttttcta cactactctc ttctccctta ctccctcttt tcacccttcc tgtgttcttg   1620

gtggggtttc cccgacctat tcagagttgg ccaggagcag caggcaccac agcctgtgtg   1680

tgtgcagata cagtgtacta ctaccaaatg gtgcccaggt tgactgctgt actgcagact   1740

gcaatggcag ctggaagttt aggtctcctc ctacctggat ctcattactt gggccgtttt   1800

caggatcgtt taatgtggat aatgattctg gaatgtggct atacttactg ctctattaac   1860

attaaggggt tagaattgca ggaaacatcc tgtcatactg cagaagctcg cagagttgat   1920

gaagtttttg aagatgcttt tgagcaagaa tacacaagag tatgttccct taatgaacac   1980

tttggaaatg tcttgacacc ctgtactgtt ttgcctgtga aattgtattc tgatgccagg   2040

aatgttctat caggcataat tgattctcat gaaaacttaa aagaatttaa aggtgacctc   2100

attaaagtac ttgtgtggat acttgttcaa tactgctcca aaaggcctgg catgaaagag   2160

aatgttcaca acactgaaaa taaagggaaa gcacctctaa tgttgcctgc tttgaacact   2220

ttgccacctc ccaaatcccc agaagacata gacagtttaa attcagaaac ttttaatgac   2280

tggtctgatg ataatatttt tgatgatgag ccaactatca aaaaagtaat agaagaaaaa   2340

catcagttga aagatttgcc aggtacaaat ttgtttattc caggatcagt agaatcacag   2400

agggttggtg atcattctac aggcactgtt cctgaaaacg atctttacaa agcagttcta   2460

ttaggatacc ctgctgttga caaaggaaaa caagaggaca tgccatatat tcctctcatg   2520

gagttcagtt gttcacattc tcacttagta tgcttacccg cagagtggag gactagctgt   2580

atgcccagtt ccaaaatgaa ggagatgagc tcgttatttc cagaagactg gtaccaattt   2640

gttctaaggc agttggaatg ttatcattca gaagagaagg cctcaaatgt actggaagaa   2700

attgccaagg acaaagtttt aaaagacttt tatgttcata cagtaatgac ttgttatttt   2760

agtttatttg gaatagacaa tatggctcct agtcctggtc atatattgag agtttacggt   2820

ggtgttttgc cttggtctgt tgctttggac tggctcacag aaaagccaga actgtttcaa   2880

ctagcactga aagcattcag gtatactctg aaactaatga ttgataaagc aagtttaggt   2940

ccaatagaag actttagaga actgattaag taccttgaag aatatgaacg tgactggtac   3000

attggtttgg tatctgatga aaagtggaag gaagcaattt tacaagaaaa gccatacttg   3060

ttttctctgg ggtatgattc taatatggga atttacactg ggagagtgct tagccttcaa   3120

gaattattga tccaagtggg aaagttaaat cctgaagctg ttagaggtca gtgggccaat   3180

ctttcatggg aattacttta tgccacaaac gatgatgaag aacgttatag tatacaagct   3240

catccactac ttttaagaaa tcttacggta caagcagcag aacctcccct gggatatccg   3300

atttattctt caaaacctct ccacatacat ttgtattaga gctcattttg actgtaatgt   3360

catcaaatgc aatgttttta ttttttcatc ctaaaaaagt aactgtgatt cttgtaactt   3420

gaggacttct ccacaccccc attcagatgc ctgagaacag ctaagctccg taaagttggt   3480

tctcttagcc atcttaatgg ttctaaaaaa cagcaaaaac atctttatgt ctaagataaa   3540

agaactattt ggccaatatt tgtgccctct ggactttagt aggctttggt aaatgtgaga   3600

aaacttttgt agaattatca tataatgaat tttgtaatgc tttcttaaat gtgttatagg   3660

tgaattgcca tacaaagtta acagctatgt aatttttaca tacttaagag ataaacatat   3720

cagtgttcta agtagtgata atggatcctg ttgaaggtta acataatgtg tatatatttg   3780

tttgaaatat aatttatagt attttcaaat gtgctgattt attttgacat ctaatatctg   3840

aatgtttttg tatcaagtag tttgttttca tagacttcaa ttcataaact ttaaaaaact   3900

tttaataaaa tattttcctt ccttttc                                       3927


<210>  11
<211>  3932
<212>  DNA
<213>  Homo sapiens

<400>  11
aacgacgctc ttgcgtaaag gcccggccca agggaacgtt cagggcgtct cggctttccc     60

cgctgctgct tctgctaggc ccagtgcgag accagagcac gagcgactcc cgtcgtcccc    120

ggccaggcag atgttggcct agtcctggcg cgaacgaagc gcgctatttc cctgcttcct    180

ctaggccaag cctgctttac ggcagggccc gcctcgggag cgagcacaga ccggggcagc    240

gaggccagcc aggcgccgac gaggtccccg aacgcgcacg cgctccgttc agctccgggt    300

ggcggccgcc ggagtagacg ttagccatgg aaaccgagag ctggcccggg cggggccgcg    360

gtgagctcgt tattcggccg ccgcagcttt tctgcctccg cattcgggca ctaaccaacc    420

tcccggcggg agcgcccagc ccgagtttac ctgcaaaaat gcggtccctg ggatgccttc    480

gcgtcttctc ttccctcggg tgacttgagg tttgtggtaa atatgccagc tctagaacac    540

atgaatcaga ttttacacat cttgtttgta tttttaccct ttctgtgggc acttgggact    600

ctgcccccac ccgatgcact tctcttatgg gcaatggagc aggttttaga gttcggcctt    660

ggaggctcat ctatgtcaac ccacttacgg ttattagtaa tgttcatcat gtctgctgga    720

acagctatag catcatattt cattccaagc actgttggtg tggttctttt catgactgga    780

tttggtttct tgctgagtct gaacttaagt gatatgggtc acaaaattgg aaccaaatct    840

aaggatttac ccagtggtcc ggaaaaacat ttttcatgga aggaatgcct tttctacatc    900

attatattag tcttggctct tttagaaact agcttgcttc atcactttgc tggcttctca    960

cagatttcta aaagcaattc ccaggctatt gtgggctatg gtttgatgat attacttata   1020

atactgtgga tacttagaga aattcaaagc gtatatatca ttggaatttt ccgaaatccc   1080

ttttatccga aggatgtgca aactgtgact gtattctttg agaagcaaac taggctcatg   1140

aagattggta ttgtcagacg gattttgcta actttagtat caccttttgc catgatagca   1200

tttctttcat tggacagttc cttacaaggg ctccactcag tgtctgtctg tattggattc   1260

acaagagcct ttagaatggt atggcagaat acagaaaatg ctttattgga gacagtcatt   1320

gtatcaacag tacacttgat ctccagtaca gacatatggt ggaacagaag cctggataca   1380

ggactcagac tcttactggt tggtatcata cgtgatcgtt tgattcagtt catctctaaa   1440

ttgcagtttg ccgtgactgt gcttttgaca tcatggacag agaaaaaaca acgtcgaaaa   1500

acaactgcca ctttatgtat actcaacatt gtcttttctc cattcgtgtt ggtcatcata   1560

gttttttcta cactactctc ttctccctta ctccctcttt tcacccttcc tgtgttcttg   1620

gtggggtttc cccgacctat tcagagttgg ccaggagcag caggcaccac agcctgtgtg   1680

tgtgcagata cagtgtacta ctaccaaatg gtgcccaggt tgactgctgt actgcagact   1740

gcaatggcag ctggaagttt aggtctcctc ctacctggat ctcattactt gggccgtttt   1800

caggatcgtt taatgtggat aatgattctg gaatgtggct atacttactg ctctattaac   1860

attaaggggt tagaattgca ggaaacatcc tgtcatactg cagaagctcg cagagttgat   1920

gaagtttttg aagatgcttt tgagcaagaa tacacaagag tatgttccct taatgaacac   1980

tttggaaatg tcttgacacc ctgtactgtt ttgcctgtga aattgtattc tgatgccagg   2040

aatgttctat caggcataat tgattctcat gaaaacttaa aagaatttaa aggtgacctc   2100

attaaagtac ttgtgtggat acttgttcaa tactgctcca aaaggcctgg catgaaagag   2160

aatgttcaca acactgaaaa taaagggaaa gcacctctaa tgttgcctgc tttgaacact   2220

ttgccacctc ccaaatcccc agaagacata gacagtttaa attcagaaac ttttaatgac   2280

tggtctgatg ataatatttt tgatgatgag ccaactatca aaaaagtaat agaagaaaaa   2340

catcagttga aagatttgcc aggtacaaat ttgtttattc caggatcagt agaatcacag   2400

agggttggtg atcattctac aggcactgtt cctgaaaacg atctttacaa agcagttcta   2460

ttaggatacc ctgctgttga caaaggaaaa caagaggaca tgccatatat tcctctcatg   2520

gagttcagtt gttcacattc tcacttagta tgcttacccg cagagtggag gactagctgt   2580

atgcccagtt ccaaaatgaa ggagatgagc tcgttatttc cagaagactg gtaccaattt   2640

gttctaaggc agttggaatg ttatcattca gaagagaagg cctcaaatgt actggaagaa   2700

attgccaagg acaaagtttt aaaagacttt tatgttcata cagtaatgac ttgttatttt   2760

agtttatttg gaatagacaa tatggctcct agtcctggtc atatattgag agtttacggt   2820

ggtgttttgc cttggtctgt tgctttggac tggctcacag aaaagccaga actgtttcaa   2880

ctagcactga aagcattcag gtatactctg aaactaatga ttgataaagc aagtttaggt   2940

ccaatagaag actttagaga actgattaag taccttgaag aatatgaacg tgactggtac   3000

attggtttgg tatctgatga aaagtggaag gaagcaattt tacaagaaaa gccatacttg   3060

ttttctctgg ggtatgattc taatatggga atttacactg ggagagtgct tagccttcaa   3120

gaattattga tccaagtggg aaagttaaat cctgaagctg ttagaggtca gtgggccaat   3180

ctttcatggg aattacttta tgccacaaac gatgatgaag aacgttatag tatacaagct   3240

catccactac ttttaagaaa tcttacggta caagcagcag aacctcccct gggatatccg   3300

atttattctt caaaacctct ccacatacat ttgtattaga gctcattttg actgtaatgt   3360

catcaaatgc aatgttttta ttttttcatc ctaaaaaagt aactgtgatt cttgtaactt   3420

gaggacttct ccacaccccc attcagatgc ctgagaacag ctaagctccg taaagttggt   3480

tctcttagcc atcttaatgg ttctaaaaaa cagcaaaaac atctttatgt ctaagataaa   3540

agaactattt ggccaatatt tgtgccctct ggactttagt aggctttggt aaatgtgaga   3600

aaacttttgt agaattatca tataatgaat tttgtaatgc tttcttaaat gtgttatagg   3660

tgaattgcca tacaaagtta acagctatgt aatttttaca tacttaagag ataaacatat   3720

cagtgttcta agtagtgata atggatcctg ttgaaggtta acataatgtg tatatatttg   3780

tttgaaatat aatttatagt attttcaaat gtgctgattt attttgacat ctaatatctg   3840

aatgtttttg tatcaagtag tttgttttca tagacttcaa ttcataaact ttaaaaaact   3900

tttaataaaa tattttcctt ccttttcaaa ta                                 3932


<210>  12
<211>  4073
<212>  DNA
<213>  Homo sapiens

<400>  12
tcttgcgtaa aggcccggcc caagggaacg ttcagggcgt ctcggctttc cccgctgctg     60

cttctgctag gcccagtgcg agaccagagc acgagcgact cccgtcgtcc ccggccaggc    120

agatgttggc ctagtcctgg cgcgaacgaa gcgcgctatt tccctgcttc ctctaggcca    180

agcctgcttt acggcagggc ccgcctcggg agcgagcaca gaccggggca gcgaggccag    240

ccaggcgccg acgaggtccc cgaacgcgca cgcgctccgt tcagctccgg gtggcggccg    300

ccggagtaga cgttagccat ggaaaccgag agctggcccg ggcggggccg cggtgagctc    360

gttattcggc cgccgcagct tttctgcctc cgcattcggg cactaaccaa cctcccggcg    420

ggagcgccca gcccgagttt acctgcaaaa atgcggtccc tgggatgcct tcgcgtcttc    480

tcttccctcg ggtgacttga gaaactgctg tgttacagaa aagcatgtga ctttcagaat    540

aatcccgagt gaggatgagt ccagatgtgc ctctactgaa tgattacaag caggacttct    600

ttctgaagcg ctttccacag actgttcttg gaggccctcg attcaaatta ggctattgtg    660

cccctcctta catatatgtt aatcaaatta ttctttttct aatgccatgg gtttggggtg    720

gagtcggaac acttttatac cagttaggca tcctgaaaga ctattataca gcagcacttt    780

caggtggatt aatgcttttt actgcatttg tcatccagtt cacaagttta tacgccaaaa    840

acaaatcaac aacagtagaa agaatactaa ccacggatat cttagcagag gaggatgagc    900

atgaatttac cagttgtact ggtgctgaga ctgtcaaatt tctcattcct ggcaagaaat    960

atgtagccaa tacagttttt cattctattc ttgctggatt agcgtgtggt cttggaacat   1020

ggtatctgct cccaaataga ataaccttgc tgtatggcag tacaggaggc actgctctac   1080

tattcttctt tggatggatg acactatgta tagcagaata ttctttaatt gtaaacacag   1140

ctacagagac tgcgactttc caaacacagg atacttatga aattattcct cttatgagac   1200

ctctttatat ttttttcttt gtttctgtgg atctggcaca caggtaaaaa cctaccaaat   1260

actttgtaac taactttgtt tttaagtata cagagtaaga gagctttcct tttagtgtta   1320

caaaaaaatg aatccatgga ttaaaaatca tcaaaccatt gggtgacagg ttattttgat   1380

aattattctt ttaggattaa tctctgtaaa acatactaaa gcaatagtta aaacttatta   1440

aagagttttt ttaaaaaacc ctttttgaga taaggaactt ttcaattttg tgtttcactt   1500

taaataagga gctttgagtt tttaagatag cctggctaaa acctgtgtaa ggagatggaa   1560

ctttcctgtg gggggaaaga agaaattaaa atttatacat ataaatatta tatacagatt   1620

gaatgaattt aagacaaata caaaatttat ttctaatttt atgatagcaa caatagtaga   1680

agtaatattg attttttaaa aaccaacttg ttacagaaga aaagtagaaa atagtttttt   1740

taacagacat aattgttcac aaaattgttt gataacccct tttacttgcc ttttcaagtt   1800

tgacttttct ttctccgtct ccgtagattg cagctttctt ttcttaggtt agtgtccagg   1860

tagaaatgtt cagcatgtta tggactgaat atttgtgtct ctccagaatt catatattac   1920

agtcttaaac cccaatgtga tggtattttg agatgaggcc tttgggaggt aattaggtca   1980

tgaaggtggg tccttggtat gatgggacta gtccccttat gagaagaggt accagagagc   2040

ttgatttgtc cctctctgtg ccatctaagg acacagcaaa aatgtggcca cctgcaagtc   2100

aaagaagaga gctctcatca aaacctgacc atactggcag cctgatcatg gtctttcggc   2160

cttcagaagt gtgagaaagt aaattgatgt tgtttaagcc actcagctta tggcattttt   2220

ttatggcagc ccatgctgat taagattttg ctaccaagaa gtgggatgcc tttgtaccaa   2280

atacctaaaa atgtggaaat ggctttgtaa ctgttggtaa tgggtagagg ctgaaagagg   2340

tttttttgtt tgtttctttg ttttgttttg tttgagatgg agtcttcact ctcttgccca   2400

ggctggagtg cagtggcaca atcttggccc actgcaacgt ccgcctcctg gcttcaagtg   2460

atactcctcc ctgagcctcc tgagtagctg gaattacaga catgcgccac catgcccggc   2520

taatttttat atttttaata gagacagggt ttcgccatgt tggccaggct ggtcccaaag   2580

tcctgacctc aagtgatcca cccgcctcgg cctcccaaag ttctgggatt acaggcttga   2640

gccatcacac ccagccaagg gttttgatgt gcatgctaga aatatggaca ttaagggtga   2700

ttctgatgaa gtctgaagtc ccctgaaccc agaggaaagg cagtccttgt tacaaagcgt   2760

caaagaactt agctgaactg tgtcctagtg ttttgtggag ccatgaagtt ggatacctac   2820

gtaaggagag ttcaaagcag tgttgaaagg agcagttggc ttctcctgtt tctagtaaaa   2880

tgtgaaagga gagagatgga ttgaagaagg gattgttaag caagagaagg aaccagaact   2940

tgaagatttg gaaaattttc agcctggatt atccatattg taaaacatga gaaagcatat   3000

tctgaagaga acaccaaaag tgtggggctg gactgtccct cagtaaagag cttttggcat   3060

tatgtgagta gaaacactgc cagtttgaat tgaagtggtt ggagacagga agtaatgaag   3120

gccgacagtt gaacttcttg gatttgacag gatgtaatga tagaactgtt cagctacaaa   3180

agtgcagtat tcttcaagaa aaggggaaaa ttatgccaaa ggtgatttaa gggtcttgag   3240

ggctaccacc tgtttcaaca agtcagctag cctctaccca aagcctcggg agcagaactg   3300

aacttcagag ccacagaagc aggaccctca cctagagcac tggcggtgac ctgccacccc   3360

agtggcctgg tgggcagagt atggaaccaa acagaattat tctcaagctc taagatctaa   3420

tggaatttgc cttgctaggt tttgacttcc ttgggatcat cacccttttt ttcctgtttc   3480

tcctattgga gtggggatgt ctcttctata cctgccctac ccttagattt tggaagcacg   3540

taactcatct ggtttcacag attcacagct ggagaggaat tttgcctcag gatggattgt   3600

acctaggtct catccatatc tgatttagat gagactttga attttagcca tcagagttaa   3660

tgctagaatg agtgaagact ttgggggata tggggatgga atgaatgtct tttgcatttg   3720

aatttggaaa ggacatgagt tttgaggggc cagggatgga atgttataga ctaattgtgt   3780

tccctcaaaa atgtttatgt tgaagcccta acccccaatg tgttggtatt tggagatggg   3840

cctctgggag gtagtttatg aaggtgagac cctagtctga taggattagt gcccttagga   3900

gagatgccaa agagcttgat gtctctcttt ttgctacaaa aagacacagc aaaaaggcag   3960

ccatgtgtaa gccaggaaga gagtcttcac cagaacctga ctatactggc agcctgatct   4020

tgtacttgta gcccccagaa ctgttagaaa ataaatttct gttgtttaag cca          4073


<210>  13
<211>  4666
<212>  DNA
<213>  Homo sapiens

<400>  13
tcttgcgtaa aggcccggcc caagggaacg ttcagggcgt ctcggctttc cccgctgctg     60

cttctgctag gcccagtgcg agaccagagc acgagcgact cccgtcgtcc ccggccaggc    120

agatgttggc ctagtcctgg cgcgaacgaa gcgcgctatt tccctgcttc ctctaggcca    180

agcctgcttt acggcagggc ccgcctcggg agcgagcaca gaccggggca gcgaggccag    240

ccaggcgccg acgaggtccc cgaacgcgca cgcgctccgt tcagctccgg gtggcggccg    300

ccggagtaga cgttagccat ggaaaccgag agctggcccg ggcggggccg cggtgagctc    360

gttattcggc cgccgcagct tttctgcctc cgcattcggg cactaaccaa cctcccggcg    420

ggagcgccca gcccgagttt acctgcaaaa atgcggtccc tgggatgcct tcgcgtcttc    480

tcttccctcg ggtgacttga gaaactgctg tgttacagaa aagcatgtga ctttcagaat    540

aatcccgagt gaggatgagt ccagatgtgc ctctactgaa tgattacaag caggacttct    600

ttctgaagcg ctttccacag actgttcttg gaggccctcg attcaaatta ggctattgtg    660

cccctcctta catatatgtt aatcaaatta ttctttttct aatgccatgg gtttggggtg    720

gagtcggaac acttttatac cagttaggca tcctgaaaga ctattataca gcagcacttt    780

caggtggatt aatgcttttt actgcatttg tcatccagtt cacaagttta tacgccaaaa    840

acaaatcaac aacagtagaa agaatactaa ccacggatat cttagcagag gaggatgagc    900

atgaatttac cagttgtact ggtgctgaga ctgtcaaatt tctcattcct ggcaagaaat    960

atgtagccaa tacagttttt cattctattc ttgctggatt agcgtgtggt cttggaacat   1020

ggtatctgct cccaaataga ataaccttgc tgtatggcag tacaggaggc actgctctac   1080

tattcttctt tggatggatg acactatgta tagcagaata ttctttaatt gtaaacacag   1140

ctacagagac tgcgactttc caaacacagg atacttatga aattattcct cttatgagac   1200

ctctttatat ttttttcttt gtttctgtgg atctggcaca caggtttgtg gtaaatatgc   1260

cagctctaga acacatgaat cagattttac acatcttgtt tgtattttta ccctttctgt   1320

gggcacttgg gactctgccc ccacccgatg cacttctctt atgggcaatg gagcaggttt   1380

tagagttcgg ccttggaggc tcatctatgt caacccactt acggttatta gtaatgttca   1440

tcatgtctgc tggaacagct atagcatcat atttcattcc aagcactgtt ggtgtggttc   1500

ttttcatgac tggatttggt ttcttgctga gtctgaactt aagtgatatg ggtcacaaaa   1560

ttggaaccaa atctaaggat ttacccagtg gtccggaaaa acatttttca tggaaggaat   1620

gccttttcta catcattata ttagtcttgg ctcttttaga aactagcttg cttcatcact   1680

ttgctggctt ctcacagatt tctaaaagca attcccaggc tattgtgggc tatggtttga   1740

tgatattact tataatactg tggatactta gagaaattca aagcgtatat atcattggaa   1800

ttttccgaaa tcccttttat ccgaaggatg tgcaaactgt gactgtattc tttgagaagc   1860

aaactaggct catgaagatt ggtattgtca gacggatttt gctaacttta gtatcacctt   1920

ttgccatgat agcatttctt tcattggaca gttccttaca agggctccac tcagtgtctg   1980

tctgtattgg attcacaaga gcctttagaa tggtatggca gaatacagaa aatgctttat   2040

tggagacagt cattgtatca acagtacact tgatctccag tacagacata tggtggaaca   2100

gaagcctgga tacaggactc agactcttac tggttggtat catacgtgat cgtttgattc   2160

agttcatctc taaattgcag tttgccgtga ctgtgctttt gacatcatgg acagagaaaa   2220

aacaacgtcg aaaaacaact gccactttat gtatactcaa cattgtcttt tctccattcg   2280

tgttggtcat catagttttt tctacactac tctcttctcc cttactccct cttttcaccc   2340

ttcctgtgtt cttggtgggg tttccccgac ctattcagag ttggccagga gcagcaggca   2400

ccacagcctg tgtgtgtgca gatacagtgt actactacca aatggtgccc aggttgactg   2460

ctgtactgca gactgcaatg gcagctggaa gtttaggtct cctcctacct ggatctcatt   2520

acttgggccg ttttcaggat cgtttaatgt ggataatgat tctggaatgt ggctatactt   2580

actgctctat taacattaag gggttagaat tgcaggaaac atcctgtcat actgcagaag   2640

ctcgcagagt tgatgaagtt tttgaagatg cttttgagca agaatacaca agagtatgtt   2700

cccttaatga acactttgga aatgtcttga caccctgtac tgttttgcct gtgaaattgt   2760

attctgatgc caggaatgtt ctatcaggca taattgattc tcatgaaaac ttaaaagaat   2820

ttaaaggtga cctcattaaa gtacttgtgt ggatacttgt tcaatactgc tccaaaaggc   2880

ctggcatgaa agagaatgtt cacaacactg aaaataaagg gaaagcacct ctaatgttgc   2940

ctgctttgaa cactttgcca cctcccaaat ccccagaaga catagacagt ttaaattcag   3000

aaacttttaa tgactggtct gatgataata tttttgatga tgagccaact atcaaaaaag   3060

taatagaaga aaaacatcag ttgaaagatt tgccaggtac aaatttgttt attccaggat   3120

cagtagaatc acagagggtt ggtgatcatt ctacaggcac tgttcctgaa aacgatcttt   3180

acaaagcagt tctattagga taccctgctg ttgacaaagg aaaacaagag gacatgccat   3240

atattcctct catggagttc agttgttcac attctcactt agtatgctta cccgcagagt   3300

ggaggactag ctgtatgccc agttccaaaa tgaaggagat gagctcgtta tttccagaag   3360

actggtacca atttgttcta aggcagttgg aatgttatca ttcagaagag aaggcctcaa   3420

atgtactgga agaaattgcc aaggacaaag ttttaaaaga cttttatgtt catacagtaa   3480

tgacttgtta ttttagttta tttggaatag acaatatggc tcctagtcct ggtcatatat   3540

tgagagttta cggtggtgtt ttgccttggt ctgttgcttt ggactggctc acagaaaagc   3600

cagaactgtt tcaactagca ctgaaagcat tcaggtatac tctgaaacta atgattgata   3660

aagcaagttt aggtccaata gaagacttta gagaactgat taagtacctt gaagaatatg   3720

aacgtgactg gtacattggt ttggtatctg atgaaaagtg gaaggaagca attttacaag   3780

aaaagccata cttgttttct ctggggtatg attctaatat gggaatttac actgggagag   3840

tgcttagcct tcaagaatta ttgatccaag tgggaaagtt aaatcctgaa gctgttagag   3900

gtcagtgggc caatctttca tgggaattac tttatgccac aaacgatgat gaagaacgtt   3960

atagtataca agctcatcca ctacttttaa gaaatcttac ggtacaagca gcagaacctc   4020

ccctgggata tccgatttat tcttcaaaac ctctccacat acatttgtat tagagctcat   4080

tttgactgta atgtcatcaa atgcaatgtt tttatttttt catcctaaaa aagtaactgt   4140

gattcttgta acttgaggac ttctccacac ccccattcag atgcctgaga acagctaagc   4200

tccgtaaagt tggttctctt agccatctta atggttctaa aaaacagcaa aaacatcttt   4260

atgtctaaga taaaagaact atttggccaa tatttgtgcc ctctggactt tagtaggctt   4320

tggtaaatgt gagaaaactt ttgtagaatt atcatataat gaattttgta atgctttctt   4380

aaatgtgtta taggtgaatt gccatacaaa gttaacagct atgtaatttt tacatactta   4440

agagataaac atatcagtgt tctaagtagt gataatggat cctgttgaag gttaacataa   4500

tgtgtatata tttgtttgaa atataattta tagtattttc aaatgtgctg atttattttg   4560

acatctaata tctgaatgtt tttgtatcaa gtagtttgtt ttcatagact tcaattcata   4620

aactttaaaa aacttttaat aaaatatttt ccttcctttt caaata                  4666


<210>  14
<211>  3513
<212>  DNA
<213>  Homo sapiens

<400>  14
aaaggcccgg cccaagggaa cgttcagggc gtctcggctt tccccgctgc tgcttctgct     60

aggcccagtg cgagaccaga gcacgagcga ctcccgtcgt ccccggccag gcagatgttg    120

gcctagtcct ggcgcgaacg aagcgcgcta tttccctgct tcctctaggc caagcctgct    180

ttacggcagg gcccgcctcg ggagcgagca cagaccgggg cagcgaggcc agccaggcgc    240

cgacgaggtc cccgaacgcg cacgcgctcc gttcagctcc gggtggcggc cgccggagta    300

gacgttagcc atggaaaccg agagctggcc cgggcggggc cgcggtgagc tcgttattcg    360

gccgccgcag cttttctgcc tccgcattcg ggcactaacc aacctcccgg cgggagcgcc    420

cagcccgagt ttacctgcaa aaatgcggtc cctgggatgc cttcgcgtct tctcttccct    480

cgggtgactt gaggtttgtg gtaaatatgc cagctctaga acacatgaat cagattttac    540

acatcttgtt tgtattttta ccctttctgt gggcacttgg gactctgccc ccacccgatg    600

cacttctctt atgggcaatg gagcaggttt tagagttcgg ccttggaggc tcatctatgt    660

caacccactt acggttatta gtaatgttca tcatgtctgc tggaacagct atagcatcat    720

atttcattcc aagcactgtt ggtgtggttc ttttcatgac tggatttggt ttcttgctga    780

gtctgaactt aagtgatatg ggtcacaaaa ttggaaccaa atctaaggat ttacccagtg    840

gtccggaaaa acatttttca tggaaggaat gccttttcta catcattata ttagtcttgg    900

ctcttttaga aactagcttg cttcatcact ttgctggctt ctcacagatt tctaaaagca    960

attcccaggc tattgtgggc tatggtttga tgatattact tataatactg tggatactta   1020

gagaaattca aagcgtatat atcattggaa ttttccgaaa tcccttttat ccgaaggatg   1080

tgcaaactgt gactgtattc tttgagaagc aaactaggct catgaagatt ggtattgtca   1140

gacggatttt gctaacttta gtatcacctt ttgccatgat agcatttctt tcattggaca   1200

gttccttaca agggctccac tcagtgtctg tctgtattgg attcacaaga gcctttagaa   1260

tggtatggca gaatacagaa aatgctttat tggagacagt cattgtatca acagtacact   1320

tgatctccag tacagacata tggtggaaca gaagcctgga tacaggactc agactcttac   1380

tggttggtat catacgtgat cgtttgattc agttcatctc taaattgcag tttgccgtga   1440

ctgtgctttt gacatcatgg acagagaaaa aacaacgtcg aaaaacaact gccactttat   1500

gtatactcaa cattgtcttt tctccattcg tgttggtcat catagttttt tctacactac   1560

tctcttctcc cttactccct cttttcaccc ttcctgtgtt cttggtgggg tttccccgac   1620

ctattcagag ttggccagga gcagcaggca ccacagcctg tgtgtgtgca gatacagtgt   1680

actactacca aatggtgccc aggttgactg ctgtactgca gactgcaatg gcagctggaa   1740

gtttaggtct cctcctacct ggatctcatt acttgggccg ttttcaggat cgtttaatgt   1800

ggataatgat tctggaatgt ggctatactt actgctctat taacattaag gggttagaat   1860

tgcaggaaac atcctgtcat actgcagaag ctcgcagagt tgatgaagtt tttgaagatg   1920

cttttgagca agaatacaca agagtatgtt cccttaatga acactttgga aatgtcttga   1980

caccctgtac tgttttgcct gtgaaattgt attctgatgc caggaatgtt ctatcaggca   2040

taattgattc tcatgaaaac ttaaaagaat ttaaaggtga cctcattaaa gtacttgtgt   2100

ggatacttgt tcaatactgc tccaaaaggc ctggcatgaa agagaatgtt cacaacactg   2160

aaaataaagg gaaagcacct ctaatgttgc ctgctttgaa cactttgcca cctcccaaat   2220

ccccagaaga catagacagt ttaaattcag aaacttttaa tgactggtct gatgataata   2280

tttttgatga tgagccaact atcaaaaaag taatagaaga aaaacatcag ttgaaagatt   2340

tgccaggtac aaatttgttt attccaggat cagtagaatc acagagggtt ggtgatcatt   2400

ctacaggcac tgttcctgaa aacgatcttt acaaagcagt tctattagga taccctgctg   2460

ttgacaaagg aaaacaagag gacatgccat atattcctct catggagttc agttgttcac   2520

attctcactt agtatgctta cccgcagagt ggaggactag ctgtatgccc agttccaaaa   2580

tgaaggagat gagctcgtta tttccagaag actggtacca atttgttcta aggcagttgg   2640

aatgttatca ttcagaagag aaggcctcaa atgtactgga agaaattgcc aaggacaaag   2700

ttttaaaaga cttttatgtt catacagtaa tgacttgtta ttttagttta tttggaatag   2760

acaatatggc tcctagtcct ggtcatatat tgagagttta cggtggtgtt ttgccttggt   2820

ctgttgcttt ggactggctc acagaaaagc cagaactgtt tcaactagca ctgaaagcat   2880

tcaggtatac tctgaaacta atgattgata aagcaagttt aggtccaata gaagacttta   2940

gagaactgat taagtacctt gaagaatatg aacgtgactg gtacattggt ttggtatctg   3000

atgaaaagtg gaaggaagca attttacaag aaaagccata cttgttttct ctggggtatg   3060

attctaatat gccaggacca gccttggaga taagcagagt gaacagaaat ttatggtctc   3120

agatttaaga aaaacaaaat tctttcttgc ttcttaaatc atactccatc ccattggctt   3180

gcaaacatgc tgacactcct cataatttca ctcttcataa accaaagcat aaggtcagag   3240

gagaacttga catattagaa cacttaggca ttgaaagtgg ttagtctaac taacccattg   3300

aagttttgga gaacctggga ctcaaatttt ggaagatgtg acagatgata tgttaacata   3360

cattgcaccg aggctgaagt gggaggattg cttgagactg cctggaaggc agaagttgca   3420

gtgagccgag actgatggtg tcactgcact ccagcctggg caacagagca agaccctgtc   3480

ttaaaaaaac aaaacaaaca aacaaaagaa acc                                3513


<210>  15
<211>  831
<212>  PRT
<213>  Homo sapiens

<400>  15

Met Lys Val His Met His Thr Lys Phe Cys Leu Ile Cys Leu Leu Thr 
1               5                   10                  15      


Phe Ile Phe His His Cys Asn His Cys His Glu Glu His Asp His Gly 
            20                  25                  30          


Pro Glu Ala Leu His Arg Gln His Arg Gly Met Thr Glu Leu Glu Pro 
        35                  40                  45              


Ser Lys Phe Ser Lys Gln Ala Ala Glu Asn Glu Lys Lys Tyr Tyr Ile 
    50                  55                  60                  


Glu Lys Leu Phe Glu Arg Tyr Gly Glu Asn Gly Arg Leu Ser Phe Phe 
65                  70                  75                  80  


Gly Leu Glu Lys Leu Leu Thr Asn Leu Gly Leu Gly Glu Arg Lys Val 
                85                  90                  95      


Val Glu Ile Asn His Glu Asp Leu Gly His Asp His Val Ser His Leu 
            100                 105                 110         


Asp Ile Leu Ala Val Gln Glu Gly Lys His Phe His Ser His Asn His 
        115                 120                 125             


Gln His Ser His Asn His Leu Asn Ser Glu Asn Gln Thr Val Thr Ser 
    130                 135                 140                 


Val Ser Thr Lys Arg Asn His Lys Cys Asp Pro Glu Lys Glu Thr Val 
145                 150                 155                 160 


Glu Val Ser Val Lys Ser Asp Asp Lys His Met His Asp His Asn His 
                165                 170                 175     


Arg Leu Arg His His His Arg Leu His His His Leu Asp His Asn Asn 
            180                 185                 190         


Thr His His Phe His Asn Asp Ser Ile Thr Pro Ser Glu Arg Gly Glu 
        195                 200                 205             


Pro Ser Asn Glu Pro Ser Thr Glu Thr Asn Lys Thr Gln Glu Gln Ser 
    210                 215                 220                 


Asp Val Lys Leu Pro Lys Gly Lys Arg Lys Lys Lys Gly Arg Lys Ser 
225                 230                 235                 240 


Asn Glu Asn Ser Glu Val Ile Thr Pro Gly Phe Pro Pro Asn His Asp 
                245                 250                 255     


Gln Gly Glu Gln Tyr Glu His Asn Arg Val His Lys Pro Asp Arg Val 
            260                 265                 270         


His Asn Pro Gly His Ser His Val His Leu Pro Glu Arg Asn Gly His 
        275                 280                 285             


Asp Pro Gly Arg Gly His Gln Asp Leu Asp Pro Asp Asn Glu Gly Glu 
    290                 295                 300                 


Leu Arg His Thr Arg Lys Arg Glu Ala Pro His Val Lys Asn Asn Ala 
305                 310                 315                 320 


Ile Ile Ser Leu Arg Lys Asp Leu Asn Glu Asp Asp His His His Glu 
                325                 330                 335     


Cys Leu Asn Val Thr Gln Leu Leu Lys Tyr Tyr Gly His Gly Ala Asn 
            340                 345                 350         


Ser Pro Ile Ser Thr Asp Leu Phe Thr Tyr Leu Cys Pro Ala Leu Leu 
        355                 360                 365             


Tyr Gln Ile Asp Ser Arg Leu Cys Ile Glu His Phe Asp Lys Leu Leu 
    370                 375                 380                 


Val Glu Asp Ile Asn Lys Asp Lys Asn Leu Val Pro Glu Asp Glu Ala 
385                 390                 395                 400 


Asn Ile Gly Ala Ser Ala Trp Ile Cys Gly Ile Ile Ser Ile Thr Val 
                405                 410                 415     


Ile Ser Leu Leu Ser Leu Leu Gly Val Ile Leu Val Pro Ile Ile Asn 
            420                 425                 430         


Gln Gly Cys Phe Lys Phe Leu Leu Thr Phe Leu Val Ala Leu Ala Val 
        435                 440                 445             


Gly Thr Met Ser Gly Asp Ala Leu Leu His Leu Leu Pro His Ser Gln 
    450                 455                 460                 


Gly Gly His Asp His Ser His Gln His Ala His Gly His Gly His Ser 
465                 470                 475                 480 


His Gly His Glu Ser Asn Lys Phe Leu Glu Glu Tyr Asp Ala Val Leu 
                485                 490                 495     


Lys Gly Leu Val Ala Leu Gly Gly Ile Tyr Leu Leu Phe Ile Ile Glu 
            500                 505                 510         


His Cys Ile Arg Met Phe Lys His Tyr Lys Gln Gln Arg Gly Lys Gln 
        515                 520                 525             


Lys Trp Phe Met Lys Gln Asn Thr Glu Glu Ser Thr Ile Gly Arg Lys 
    530                 535                 540                 


Leu Ser Asp His Lys Leu Asn Asn Thr Pro Asp Ser Asp Trp Leu Gln 
545                 550                 555                 560 


Leu Lys Pro Leu Ala Gly Thr Asp Asp Ser Val Val Ser Glu Asp Arg 
                565                 570                 575     


Leu Asn Glu Thr Glu Leu Thr Asp Leu Glu Gly Gln Gln Glu Ser Pro 
            580                 585                 590         


Pro Lys Asn Tyr Leu Cys Ile Glu Glu Glu Lys Ile Ile Asp His Ser 
        595                 600                 605             


His Ser Asp Gly Leu His Thr Ile His Glu His Asp Leu His Ala Ala 
    610                 615                 620                 


Ala His Asn His His Gly Glu Asn Lys Thr Val Leu Arg Lys His Asn 
625                 630                 635                 640 


His Gln Trp His His Lys His Ser His His Ser His Gly Pro Cys His 
                645                 650                 655     


Ser Gly Ser Asp Leu Lys Glu Thr Gly Ile Ala Asn Ile Ala Trp Met 
            660                 665                 670         


Val Ile Met Gly Asp Gly Ile His Asn Phe Ser Asp Gly Leu Ala Ile 
        675                 680                 685             


Gly Ala Ala Phe Ser Ala Gly Leu Thr Gly Gly Ile Ser Thr Ser Ile 
    690                 695                 700                 


Ala Val Phe Cys His Glu Leu Pro His Glu Leu Gly Asp Phe Ala Val 
705                 710                 715                 720 


Leu Leu Lys Ala Gly Met Thr Val Lys Gln Ala Ile Val Tyr Asn Leu 
                725                 730                 735     


Leu Ser Ala Met Met Ala Tyr Ile Gly Met Leu Ile Gly Thr Ala Val 
            740                 745                 750         


Gly Gln Tyr Ala Asn Asn Ile Thr Leu Trp Ile Phe Ala Val Thr Ala 
        755                 760                 765             


Gly Met Phe Leu Tyr Val Ala Leu Val Asp Met Leu Pro Glu Met Leu 
    770                 775                 780                 


His Gly Asp Gly Asp Asn Glu Glu His Gly Phe Cys Pro Val Gly Gln 
785                 790                 795                 800 


Phe Ile Leu Gln Asn Leu Gly Leu Leu Phe Gly Phe Ala Ile Met Leu 
                805                 810                 815     


Val Ile Ala Leu Tyr Glu Asp Lys Ile Val Phe Asp Ile Gln Phe 
            820                 825                 830     


<210>  16
<211>  831
<212>  PRT
<213>  Homo sapiens

<400>  16

Met Lys Val His Met His Thr Lys Phe Cys Leu Ile Cys Leu Leu Thr 
1               5                   10                  15      


Phe Ile Phe His His Cys Asn His Cys His Glu Glu His Asp His Gly 
            20                  25                  30          


Pro Glu Ala Leu His Arg Gln His Arg Gly Met Thr Glu Leu Glu Pro 
        35                  40                  45              


Ser Lys Phe Ser Lys Gln Ala Ala Glu Asn Glu Lys Lys Tyr Tyr Ile 
    50                  55                  60                  


Glu Lys Leu Phe Glu Arg Tyr Gly Glu Asn Gly Arg Leu Ser Phe Phe 
65                  70                  75                  80  


Gly Leu Glu Lys Leu Leu Thr Asn Leu Gly Leu Gly Glu Arg Lys Val 
                85                  90                  95      


Val Glu Ile Asn His Glu Asp Leu Gly His Asp His Val Ser His Leu 
            100                 105                 110         


Asp Ile Leu Ala Val Gln Glu Gly Lys His Phe His Ser His Asn His 
        115                 120                 125             


Gln His Ser His Asn His Leu Asn Ser Glu Asn Gln Thr Val Thr Ser 
    130                 135                 140                 


Val Ser Thr Lys Arg Asn His Lys Cys Asp Pro Glu Lys Glu Thr Val 
145                 150                 155                 160 


Glu Val Ser Val Lys Ser Asp Asp Lys His Met His Asp His Asn His 
                165                 170                 175     


Arg Leu Arg His His His Arg Leu His His His Leu Asp His Asn Asn 
            180                 185                 190         


Thr His His Phe His Asn Asp Ser Ile Thr Pro Ser Glu Arg Gly Glu 
        195                 200                 205             


Pro Ser Asn Glu Pro Ser Thr Glu Thr Asn Lys Thr Gln Glu Gln Ser 
    210                 215                 220                 


Asp Val Lys Leu Pro Lys Gly Lys Arg Lys Lys Lys Gly Arg Lys Ser 
225                 230                 235                 240 


Asn Glu Asn Ser Glu Val Ile Thr Pro Gly Phe Pro Pro Asn His Asp 
                245                 250                 255     


Gln Gly Glu Gln Tyr Glu His Asn Arg Val His Lys Pro Asp Arg Val 
            260                 265                 270         


His Asn Pro Gly His Ser His Val His Leu Pro Glu Arg Asn Gly His 
        275                 280                 285             


Asp Pro Gly Arg Gly His Gln Asp Leu Asp Pro Asp Asn Glu Gly Glu 
    290                 295                 300                 


Leu Arg His Thr Arg Lys Arg Glu Ala Pro His Val Lys Asn Asn Ala 
305                 310                 315                 320 


Ile Ile Ser Leu Arg Lys Asp Leu Asn Glu Asp Asp His His His Glu 
                325                 330                 335     


Cys Leu Asn Val Thr Gln Leu Leu Lys Tyr Tyr Gly His Gly Ala Asn 
            340                 345                 350         


Ser Pro Ile Ser Thr Asp Leu Phe Thr Tyr Leu Cys Pro Ala Leu Leu 
        355                 360                 365             


Tyr Gln Ile Asp Ser Arg Leu Cys Ile Glu His Phe Asp Lys Leu Leu 
    370                 375                 380                 


Val Glu Asp Ile Asn Lys Asp Lys Asn Leu Val Pro Glu Asp Glu Ala 
385                 390                 395                 400 


Asn Ile Gly Ala Ser Ala Trp Ile Cys Gly Ile Ile Ser Ile Thr Val 
                405                 410                 415     


Ile Ser Leu Leu Ser Leu Leu Gly Val Ile Leu Val Pro Ile Ile Asn 
            420                 425                 430         


Gln Gly Cys Phe Lys Phe Leu Leu Thr Phe Leu Val Ala Leu Ala Val 
        435                 440                 445             


Gly Thr Met Ser Gly Asp Ala Leu Leu His Leu Leu Pro His Ser Gln 
    450                 455                 460                 


Gly Gly His Asp His Ser His Gln His Ala His Gly His Gly His Ser 
465                 470                 475                 480 


His Gly His Glu Ser Asn Lys Phe Leu Glu Glu Tyr Asp Ala Val Leu 
                485                 490                 495     


Lys Gly Leu Val Ala Leu Gly Gly Ile Tyr Leu Leu Phe Ile Ile Glu 
            500                 505                 510         


His Cys Ile Arg Met Phe Lys His Tyr Lys Gln Gln Arg Gly Lys Gln 
        515                 520                 525             


Lys Trp Phe Met Lys Gln Asn Thr Glu Glu Ser Thr Ile Gly Arg Lys 
    530                 535                 540                 


Leu Ser Asp His Lys Leu Asn Asn Thr Pro Asp Ser Asp Trp Leu Gln 
545                 550                 555                 560 


Leu Lys Pro Leu Ala Gly Thr Asp Asp Ser Val Val Ser Glu Asp Arg 
                565                 570                 575     


Leu Asn Glu Thr Glu Leu Thr Asp Leu Glu Gly Gln Gln Glu Ser Pro 
            580                 585                 590         


Pro Lys Asn Tyr Leu Cys Ile Glu Glu Glu Lys Ile Ile Asp His Ser 
        595                 600                 605             


His Ser Asp Gly Leu His Thr Ile His Glu His Asp Leu His Ala Ala 
    610                 615                 620                 


Ala His Asn His His Gly Glu Asn Lys Thr Val Leu Arg Lys His Asn 
625                 630                 635                 640 


His Gln Trp His His Lys His Ser His His Ser His Gly Pro Cys His 
                645                 650                 655     


Ser Gly Ser Asp Leu Lys Glu Thr Gly Ile Ala Asn Ile Ala Trp Met 
            660                 665                 670         


Val Ile Met Gly Asp Gly Ile His Asn Phe Ser Asp Gly Leu Ala Ile 
        675                 680                 685             


Gly Ala Ala Phe Ser Ala Gly Leu Thr Gly Gly Ile Ser Thr Ser Ile 
    690                 695                 700                 


Ala Val Phe Cys His Glu Leu Pro His Glu Leu Gly Asp Phe Ala Val 
705                 710                 715                 720 


Leu Leu Lys Ala Gly Met Thr Val Lys Gln Ala Ile Val Tyr Asn Leu 
                725                 730                 735     


Leu Ser Ala Met Met Ala Tyr Ile Gly Met Leu Ile Gly Thr Ala Val 
            740                 745                 750         


Gly Gln Tyr Ala Asn Asn Ile Thr Leu Trp Ile Phe Ala Val Thr Ala 
        755                 760                 765             


Gly Met Phe Leu Tyr Val Ala Leu Val Asp Met Leu Pro Glu Met Leu 
    770                 775                 780                 


His Gly Asp Gly Asp Asn Glu Glu His Gly Phe Cys Pro Val Gly Gln 
785                 790                 795                 800 


Phe Ile Leu Gln Asn Leu Gly Leu Leu Phe Gly Phe Ala Ile Met Leu 
                805                 810                 815     


Val Ile Ala Leu Tyr Glu Asp Lys Ile Val Phe Asp Ile Gln Phe 
            820                 825                 830     


<210>  17
<211>  5227
<212>  DNA
<213>  Homo sapiens

<400>  17
cacgatttgg tgcagccggg gtttggtacc gagcggagag gagatgcaca cggcactcga     60

gtgtgaggaa aaatagaaat gaaggtacat atgcacacaa aattttgcct catttgtttg    120

ctgacattta tttttcatca ttgcaaccat tgccatgaag aacatgacca tggccctgaa    180

gcgcttcaca gacagcatcg tggaatgaca gaattggagc caagcaaatt ttcaaagcaa    240

gctgctgaaa atgaaaaaaa atactatatt gaaaaacttt ttgagcgtta tggtgaaaat    300

ggaagattat ccttttttgg tttggagaaa cttttaacaa acttgggcct tggagagaga    360

aaagtagttg agattaatca tgaggatctt ggccacgatc atgtttctca tttagatatt    420

ttggcagttc aagagggaaa gcattttcac tcacataacc accagcattc ccataatcat    480

ttaaattcag aaaatcaaac tgtgaccagt gtatccacaa aaagaaacca taaatgtgat    540

ccagagaaag agacagttga agtgtctgta aaatctgatg ataaacatat gcatgaccat    600

aatcaccgcc tacgtcatca ccatcgtttg catcatcatc ttgatcataa caacactcac    660

cattttcata atgattccat tactcccagt gagcgtgggg agcctagcaa tgaaccttca    720

acagagacca ataaaaccca ggaacaatct gatgttaaac taccgaaagg aaagaggaag    780

aaaaaaggga ggaaaagtaa tgaaaattct gaggttatta caccaggttt tccccctaac    840

catgatcagg gtgaacagta tgagcataat cgggtccaca aacctgatcg tgtacataac    900

ccaggtcatt ctcatgtaca tcttccagaa cgtaatggtc atgatcctgg tcgtggacac    960

caagatcttg atcctgataa tgaaggtgaa cttcgacata ctagaaagag agaagcacca   1020

catgttaaaa ataatgcaat aatttctttg agaaaagatc taaatgaaga tgaccatcat   1080

catgaatgtt tgaacgtcac tcagttatta aaatactatg gtcatggtgc caactctccc   1140

atctcaactg atttatttac atacctttgc cctgcattgt tatatcaaat cgacagcaga   1200

ctttgtattg agcattttga caaactttta gttgaagata taaataagga taaaaacctg   1260

gttcctgaag atgaggcaaa tataggggca tcagcctgga tttgtggtat catttctatc   1320

actgtcatta gcctgctttc cttgctaggc gtgatcttgg ttcctatcat taaccaagga   1380

tgcttcaaat tccttcttac attccttgtt gcattagctg taggaacaat gagtggagac   1440

gcccttcttc atctactgcc ccattctcag ggtggacatg atcacagtca ccaacatgca   1500

catgggcatg gacattctca tggacatgaa tctaacaagt ttttggaaga atatgatgct   1560

gtattgaaag gacttgttgc tctaggaggc atttacttgc tatttatcat tgaacactgc   1620

attagaatgt ttaagcacta caaacaacaa agaggaaaac agaaatggtt tatgaaacag   1680

aacacagaag aatcaactat tggaagaaag ctttcagatc acaagttaaa caatacacca   1740

gattctgact ggcttcaact caagcctctt gccggaactg atgactcggt tgtttctgaa   1800

gatcgactta atgaaactga actgacagat ttagaaggcc aacaagaatc ccctcctaaa   1860

aattaccttt gtatagaaga ggagaaaatc atagaccatt ctcacagtga tggattacat   1920

accattcatg agcatgatct ccatgctgct gcacataacc accacggcga gaacaaaact   1980

gtgctgagga agcataatca ccagtggcac cacaagcatt ctcatcattc ccatggcccc   2040

tgtcattctg gatccgatct gaaagaaaca ggaatagcta atatagcctg gatggtgatc   2100

atgggggatg gcatccacaa cttcagtgat gggctcgcaa ttggtgcagc tttcagtgct   2160

ggattgacag gaggaatcag tacttctata gccgtcttct gtcatgaact gccacatgaa   2220

ttaggagatt ttgcagttct tcttaaagca ggcatgactg taaagcaagc aattgtatac   2280

aacctcctct ctgccatgat ggcttacata ggcatgctca taggcacagc tgttggtcag   2340

tatgccaata acatcacact ttggatcttt gcagtcactg caggcatgtt cctctatgta   2400

gccttggtgg atatgcttcc agaaatgttg catggtgatg gtgacaatga agaacatggc   2460

ttttgtcctg tggggcaatt catccttcag aatttaggat tgctctttgg atttgccatt   2520

atgctggtga ttgccctcta tgaagataaa attgtgtttg acatccagtt ttgacctttc   2580

ccagtaatca ctgttgatta cgagaatgtt accatgcagc tttgcatctg ttccttgtac   2640

tgtatgcaca ttgctcaaag gaaagtcagt ggcttgcact acttacaagt ttcatagatt   2700

tgagcctaac cacaagaggc tggtgcttag tactgttttc cctgcacgta ggggtctttt   2760

aaaaatataa agcttgtgat aaagagagga gaatatggga ctccatgaac cagtgttgat   2820

atgtttgatt aagacttttc acaaaataat catataaaac actagtctct ttattagtag   2880

aaacttctgt ggctatgcag aaatagagat cgaaccaaaa aaaatcattt aaactttaaa   2940

aatattttaa atggactttg gggagacatt ttttgtgtgt tttaagaatg aattgtagtg   3000

ctctttaatt cagctacata tattcatgtg gtgataggga tcaacttgac acaactttga   3060

aactgcataa agtagacata ggaactagag gaaagctcag gctgcattag agtatgaatt   3120

tagcattggg aaaagccctt attcttgaat ctagagttac tatttttgta tatatttgca   3180

tagtgtttaa acctgcagcc taaactactg aaatttgtga ttgtatgttt gtgtgagctt   3240

cagtttaatg aaagattcat aatggttctt tgtattatta taatacttgg tgttggggtg   3300

ttctttctgt tttgtttttt actttaattt tgttttgatt tttttttttt ttttttggcg   3360

ggggtaggtg agggtttgga gcatgtggtc tttttaaaaa attgtaaccc tctagaaaat   3420

atcaaagaaa tgaaccagac gtggtttaaa tagttgattt tcctatttta acagtaccaa   3480

ctagttaatt gggaaatgta agttctgaat gttcacattg ctttaccagt ttggcactgg   3540

aaccaagagc acatgtcgtg gctggctaca aggttgtaaa gcagaaaatc gaagtttacc   3600

atgtctgtaa tgtgtacatg aagtgtcaat ttagaacagt tactaggata aactccatta   3660

ttgccatggc tgtcatggta cccaagtgac ttggaagatg catttaaatt actcagctga   3720

aatcacttga tcatcttgtg ccaagatatg ctgttggtgc ctgataggga ttagtctttt   3780

aggtgccctg ttctcctacc ataattgtga atgatttgtg agaagtgcaa gccatgttta   3840

tcctgaattt ttacttaata atttgtatta ctagtcatat gcatgtagct ttctgtttac   3900

atcctatgcc acatggtctt catttatgcc aggtaaactg tatttgaact atgtgcagct   3960

agctttgttt taatctgctt ggcaaccagt gtagctgctg taacaatcta tcttattgtt   4020

caaatatata agagccaaac tcttttccat tccatctaaa atgttttcat ttagtactct   4080

tctttcctcc tactctatga acttcaaaac aaaaacaaaa ctttgagagc agcacatgca   4140

tccaggtatt tatagattat tgccagtgtc ttttctgtat gctataagca agggagctta   4200

ggtgttattt ctttaattta tgcttgaatc tgaaaaatta tttctgactt actccatggc   4260

ctccttataa taagtagaag ttttatatat aattaatttt cagcattggg cactgaatta   4320

ggacagtcct catctcattg cttggccctt caagcaacct agctaaaagg tgctgatatt   4380

ttatttagta ctgccaactt caagtgattt agatatctat ctatctagat ttctgaacca   4440

agatatattt atagttcact tttgggtttt tatacccacg gtaggattct gcattccagc   4500

attaaatctg cttcatttta gaacctttat aaaagcaata gctggaatat actcccagtt   4560

ttaaaataaa tgcctgattg atttaaagca agtaggttat gctgaagtat ataaagaagt   4620

tttatattct ctcaaaaatg gtattatctt tctttatttg ctagattctt acaaatcttt   4680

taagagggct gtaacagttg ctgctagtat tagggttcca catcattcta atgtatagtt   4740

tcaagtctta atagacaatc tgaattccac tacatttctt ttggctccaa cattcctttt   4800

agcttgacca gtctaattta aaatgtgttt gttggaggtc attaacgtta cttgtacaat   4860

gctgtcactg tgtgacatcc atatgaattt tggtatatat caatcaatca atcaatcaca   4920

ttgcattcaa tcaatcagct gtgattgatt gattatgctt agaaatacta tagtaactag   4980

atgcagtgtg aattttttcc attaacaaac aaacaagtca gtggcttaaa tgtgattatg   5040

gtcctgcaag gtgattcttg ctaaaatatc taaacttttg ttttgtttta actgaatcat   5100

tttttaactt aaaaagctgg aaaatatcaa atgctgtttt ttttttttca ttgtcaacag   5160

tggtgtgtca ttttatgtat gttcctaatg cttatggaac tcctccaaaa taaagttact   5220

caaagag                                                             5227


<210>  18
<211>  5432
<212>  DNA
<213>  Homo sapiens

<400>  18
agttgatcac tctgaagctt tttggctaaa gcgtttgggt ttagagcttc cattactcat     60

tcgccttgcc caaggcctca gcaaccgacg ttcgaaagcc aggagaaaag gcgaatgata    120

aagggcgctc cacgcatgcg ttaagaagcc gccccaactc ccccgcggcg ttctttcttg    180

gaacaaaact agcgcggagc cacggaactc cgcagtttgc gtagacttga atttcctatt    240

cctcggacga tccatgtgga atccgaaaaa tagaaatgaa ggtacatatg cacacaaaat    300

tttgcctcat ttgtttgctg acatttattt ttcatcattg caaccattgc catgaagaac    360

atgaccatgg ccctgaagcg cttcacagac agcatcgtgg aatgacagaa ttggagccaa    420

gcaaattttc aaagcaagct gctgaaaatg aaaaaaaata ctatattgaa aaactttttg    480

agcgttatgg tgaaaatgga agattatcct tttttggttt ggagaaactt ttaacaaact    540

tgggccttgg agagagaaaa gtagttgaga ttaatcatga ggatcttggc cacgatcatg    600

tttctcattt agatattttg gcagttcaag agggaaagca ttttcactca cataaccacc    660

agcattccca taatcattta aattcagaaa atcaaactgt gaccagtgta tccacaaaaa    720

gaaaccataa atgtgatcca gagaaagaga cagttgaagt gtctgtaaaa tctgatgata    780

aacatatgca tgaccataat caccgcctac gtcatcacca tcgtttgcat catcatcttg    840

atcataacaa cactcaccat tttcataatg attccattac tcccagtgag cgtggggagc    900

ctagcaatga accttcaaca gagaccaata aaacccagga acaatctgat gttaaactac    960

cgaaaggaaa gaggaagaaa aaagggagga aaagtaatga aaattctgag gttattacac   1020

caggttttcc ccctaaccat gatcagggtg aacagtatga gcataatcgg gtccacaaac   1080

ctgatcgtgt acataaccca ggtcattctc atgtacatct tccagaacgt aatggtcatg   1140

atcctggtcg tggacaccaa gatcttgatc ctgataatga aggtgaactt cgacatacta   1200

gaaagagaga agcaccacat gttaaaaata atgcaataat ttctttgaga aaagatctaa   1260

atgaagatga ccatcatcat gaatgtttga acgtcactca gttattaaaa tactatggtc   1320

atggtgccaa ctctcccatc tcaactgatt tatttacata cctttgccct gcattgttat   1380

atcaaatcga cagcagactt tgtattgagc attttgacaa acttttagtt gaagatataa   1440

ataaggataa aaacctggtt cctgaagatg aggcaaatat aggggcatca gcctggattt   1500

gtggtatcat ttctatcact gtcattagcc tgctttcctt gctaggcgtg atcttggttc   1560

ctatcattaa ccaaggatgc ttcaaattcc ttcttacatt ccttgttgca ttagctgtag   1620

gaacaatgag tggagacgcc cttcttcatc tactgcccca ttctcagggt ggacatgatc   1680

acagtcacca acatgcacat gggcatggac attctcatgg acatgaatct aacaagtttt   1740

tggaagaata tgatgctgta ttgaaaggac ttgttgctct aggaggcatt tacttgctat   1800

ttatcattga acactgcatt agaatgttta agcactacaa acaacaaaga ggaaaacaga   1860

aatggtttat gaaacagaac acagaagaat caactattgg aagaaagctt tcagatcaca   1920

agttaaacaa tacaccagat tctgactggc ttcaactcaa gcctcttgcc ggaactgatg   1980

actcggttgt ttctgaagat cgacttaatg aaactgaact gacagattta gaaggccaac   2040

aagaatcccc tcctaaaaat tacctttgta tagaagagga gaaaatcata gaccattctc   2100

acagtgatgg attacatacc attcatgagc atgatctcca tgctgctgca cataaccacc   2160

acggcgagaa caaaactgtg ctgaggaagc ataatcacca gtggcaccac aagcattctc   2220

atcattccca tggcccctgt cattctggat ccgatctgaa agaaacagga atagctaata   2280

tagcctggat ggtgatcatg ggggatggca tccacaactt cagtgatggg ctcgcaattg   2340

gtgcagcttt cagtgctgga ttgacaggag gaatcagtac ttctatagcc gtcttctgtc   2400

atgaactgcc acatgaatta ggagattttg cagttcttct taaagcaggc atgactgtaa   2460

agcaagcaat tgtatacaac ctcctctctg ccatgatggc ttacataggc atgctcatag   2520

gcacagctgt tggtcagtat gccaataaca tcacactttg gatctttgca gtcactgcag   2580

gcatgttcct ctatgtagcc ttggtggata tgcttccaga aatgttgcat ggtgatggtg   2640

acaatgaaga acatggcttt tgtcctgtgg ggcaattcat ccttcagaat ttaggattgc   2700

tctttggatt tgccattatg ctggtgattg ccctctatga agataaaatt gtgtttgaca   2760

tccagttttg acctttccca gtaatcactg ttgattacga gaatgttacc atgcagcttt   2820

gcatctgttc cttgtactgt atgcacattg ctcaaaggaa agtcagtggc ttgcactact   2880

tacaagtttc atagatttga gcctaaccac aagaggctgg tgcttagtac tgttttccct   2940

gcacgtaggg gtcttttaaa aatataaagc ttgtgataaa gagaggagaa tatgggactc   3000

catgaaccag tgttgatatg tttgattaag acttttcaca aaataatcat ataaaacact   3060

agtctcttta ttagtagaaa cttctgtggc tatgcagaaa tagagatcga accaaaaaaa   3120

atcatttaaa ctttaaaaat attttaaatg gactttgggg agacattttt tgtgtgtttt   3180

aagaatgaat tgtagtgctc tttaattcag ctacatatat tcatgtggtg atagggatca   3240

acttgacaca actttgaaac tgcataaagt agacatagga actagaggaa agctcaggct   3300

gcattagagt atgaatttag cattgggaaa agcccttatt cttgaatcta gagttactat   3360

ttttgtatat atttgcatag tgtttaaacc tgcagcctaa actactgaaa tttgtgattg   3420

tatgtttgtg tgagcttcag tttaatgaaa gattcataat ggttctttgt attattataa   3480

tacttggtgt tggggtgttc tttctgtttt gttttttact ttaattttgt tttgattttt   3540

tttttttttt tttggcgggg gtaggtgagg gtttggagca tgtggtcttt ttaaaaaatt   3600

gtaaccctct agaaaatatc aaagaaatga accagacgtg gtttaaatag ttgattttcc   3660

tattttaaca gtaccaacta gttaattggg aaatgtaagt tctgaatgtt cacattgctt   3720

taccagtttg gcactggaac caagagcaca tgtcgtggct ggctacaagg ttgtaaagca   3780

gaaaatcgaa gtttaccatg tctgtaatgt gtacatgaag tgtcaattta gaacagttac   3840

taggataaac tccattattg ccatggctgt catggtaccc aagtgacttg gaagatgcat   3900

ttaaattact cagctgaaat cacttgatca tcttgtgcca agatatgctg ttggtgcctg   3960

atagggatta gtcttttagg tgccctgttc tcctaccata attgtgaatg atttgtgaga   4020

agtgcaagcc atgtttatcc tgaattttta cttaataatt tgtattacta gtcatatgca   4080

tgtagctttc tgtttacatc ctatgccaca tggtcttcat ttatgccagg taaactgtat   4140

ttgaactatg tgcagctagc tttgttttaa tctgcttggc aaccagtgta gctgctgtaa   4200

caatctatct tattgttcaa atatataaga gccaaactct tttccattcc atctaaaatg   4260

ttttcattta gtactcttct ttcctcctac tctatgaact tcaaaacaaa aacaaaactt   4320

tgagagcagc acatgcatcc aggtatttat agattattgc cagtgtcttt tctgtatgct   4380

ataagcaagg gagcttaggt gttatttctt taatttatgc ttgaatctga aaaattattt   4440

ctgacttact ccatggcctc cttataataa gtagaagttt tatatataat taattttcag   4500

cattgggcac tgaattagga cagtcctcat ctcattgctt ggcccttcaa gcaacctagc   4560

taaaaggtgc tgatatttta tttagtactg ccaacttcaa gtgatttaga tatctatcta   4620

tctagatttc tgaaccaaga tatatttata gttcactttt gggtttttat acccacggta   4680

ggattctgca ttccagcatt aaatctgctt cattttagaa cctttataaa agcaatagct   4740

ggaatatact cccagtttta aaataaatgc ctgattgatt taaagcaagt aggttatgct   4800

gaagtatata aagaagtttt atattctctc aaaaatggta ttatctttct ttatttgcta   4860

gattcttaca aatcttttaa gagggctgta acagttgctg ctagtattag ggttccacat   4920

cattctaatg tatagtttca agtcttaata gacaatctga attccactac atttcttttg   4980

gctccaacat tccttttagc ttgaccagtc taatttaaaa tgtgtttgtt ggaggtcatt   5040

aacgttactt gtacaatgct gtcactgtgt gacatccata tgaattttgg tatatatcaa   5100

tcaatcaatc aatcacattg cattcaatca atcagctgtg attgattgat tatgcttaga   5160

aatactatag taactagatg cagtgtgaat tttttccatt aacaaacaaa caagtcagtg   5220

gcttaaatgt gattatggtc ctgcaaggtg attcttgcta aaatatctaa acttttgttt   5280

tgttttaact gaatcatttt ttaacttaaa aagctggaaa atatcaaatg ctgttttttt   5340

tttttcattg tcaacagtgg tgtgtcattt tatgtatgtt cctaatgctt atggaactcc   5400

tccaaaataa agttactcaa agagagcaaa ta                                 5432


<210>  19
<211>  132
<212>  PRT
<213>  Homo sapiens

<400>  19

Met Ser Gln Gly Arg His Leu Leu Glu Phe Leu Pro Leu Tyr Ile Ala 
1               5                   10                  15      


Phe Met Leu Arg Gly Val Cys Arg Ile Asp Ala Gly Ser Leu Asn Pro 
            20                  25                  30          


Glu Leu Phe Leu Pro Met Leu His Glu Glu Asp Trp Cys Trp Glu Ile 
        35                  40                  45              


Ala Gly His Val Asp Ser Gln Glu Leu Phe Val Gly Leu Phe Ser Ser 
    50                  55                  60                  


Thr Ser Thr Gly His Ala Glu Leu Asp Lys Lys Val Asn Gly Leu Tyr 
65                  70                  75                  80  


Tyr Asp Ser Val Phe Gln Leu Ser Leu Asp Arg Met Arg His Thr Arg 
                85                  90                  95      


Ser Met Ala Arg Val Glu Arg Leu Arg His Arg Lys Ala Ile Gln Lys 
            100                 105                 110         


Lys Thr Gln Leu Val His His Leu Leu Phe Lys Gly Trp Ala Ser Asp 
        115                 120                 125             


Glu Thr Glu Ile 
    130         


<210>  20
<211>  399
<212>  DNA
<213>  Homo sapiens

<400>  20
atgtcacaag gcaggcatct tcttgagttt cttccattgt acatagcttt catgttacgt     60

ggggtttgta ggatagacgc tggaagcctt aatccagaac tgtttttgcc aatgttacat    120

gaagaggatt ggtgttggga gatagctggc catgtggact cccaagagtt attcgttggt    180

ttgttttcta gtacctctac tgggcatgca gagctggaca aaaaggttaa tggactttat    240

tatgactctg tattccagtt gtctctggac cgtatgcgtc atacaaggag tatggctaga    300

gtagagaggc tgagacacag gaaagcgatc cagaaaaaga ctcagttagt ccatcatctg    360

ctatttaaag gatgggcttc tgatgaaact gaaatttag                           399


<210>  21
<211>  316
<212>  PRT
<213>  Homo sapiens

<400>  21

Met Ala Ser Ala Asp Glu Leu Thr Phe His Glu Phe Glu Glu Ala Thr 
1               5                   10                  15      


Asn Leu Leu Ala Asp Thr Pro Asp Ala Ala Thr Thr Ser Arg Ser Asp 
            20                  25                  30          


Gln Leu Thr Pro Gln Gly His Val Ala Val Ala Val Gly Ser Gly Gly 
        35                  40                  45              


Ser Tyr Gly Ala Glu Asp Glu Val Glu Glu Glu Ser Asp Lys Ala Ala 
    50                  55                  60                  


Leu Leu Gln Glu Gln Gln Gln Gln Gln Gln Pro Gly Phe Trp Thr Phe 
65                  70                  75                  80  


Ser Tyr Tyr Gln Ser Phe Phe Asp Val Asp Thr Ser Gln Val Leu Asp 
                85                  90                  95      


Arg Ile Lys Gly Ser Leu Leu Pro Arg Pro Gly His Asn Phe Val Arg 
            100                 105                 110         


His His Leu Arg Asn Arg Pro Asp Leu Tyr Gly Pro Phe Trp Ile Cys 
        115                 120                 125             


Ala Thr Leu Ala Phe Val Leu Ala Val Thr Gly Asn Leu Thr Leu Val 
    130                 135                 140                 


Leu Ala Gln Arg Arg Asp Pro Ser Ile His Tyr Ser Pro Gln Phe His 
145                 150                 155                 160 


Lys Val Thr Val Ala Gly Ile Ser Ile Tyr Cys Tyr Ala Trp Leu Val 
                165                 170                 175     


Pro Leu Ala Leu Trp Gly Phe Leu Arg Trp Arg Lys Gly Val Gln Glu 
            180                 185                 190         


Arg Met Gly Pro Tyr Thr Phe Leu Glu Thr Val Cys Ile Tyr Gly Tyr 
        195                 200                 205             


Ser Leu Phe Val Phe Ile Pro Met Val Val Leu Trp Leu Ile Pro Val 
    210                 215                 220                 


Pro Trp Leu Gln Trp Leu Phe Gly Ala Leu Ala Leu Gly Leu Ser Ala 
225                 230                 235                 240 


Ala Gly Leu Val Phe Thr Leu Trp Pro Val Val Arg Glu Asp Thr Arg 
                245                 250                 255     


Leu Val Ala Thr Val Leu Leu Ser Val Val Val Leu Leu His Ala Leu 
            260                 265                 270         


Leu Ala Met Gly Cys Lys Leu Tyr Phe Phe Gln Ser Leu Pro Pro Glu 
        275                 280                 285             


Asn Val Ala Pro Pro Pro Gln Ile Thr Ser Leu Pro Ser Asn Ile Ala 
    290                 295                 300                 


Leu Ser Pro Thr Leu Pro Gln Ser Leu Ala Pro Ser 
305                 310                 315     


<210>  22
<211>  316
<212>  PRT
<213>  Homo sapiens

<400>  22

Met Ala Ser Ala Asp Glu Leu Thr Phe His Glu Phe Glu Glu Ala Thr 
1               5                   10                  15      


Asn Leu Leu Ala Asp Thr Pro Asp Ala Ala Thr Thr Ser Arg Ser Asp 
            20                  25                  30          


Gln Leu Thr Pro Gln Gly His Val Ala Val Ala Val Gly Ser Gly Gly 
        35                  40                  45              


Ser Tyr Gly Ala Glu Asp Glu Val Glu Glu Glu Ser Asp Lys Ala Ala 
    50                  55                  60                  


Leu Leu Gln Glu Gln Gln Gln Gln Gln Gln Pro Gly Phe Trp Thr Phe 
65                  70                  75                  80  


Ser Tyr Tyr Gln Ser Phe Phe Asp Val Asp Thr Ser Gln Val Leu Asp 
                85                  90                  95      


Arg Ile Lys Gly Ser Leu Leu Pro Arg Pro Gly His Asn Phe Val Arg 
            100                 105                 110         


His His Leu Arg Asn Arg Pro Asp Leu Tyr Gly Pro Phe Trp Ile Cys 
        115                 120                 125             


Ala Thr Leu Ala Phe Val Leu Ala Val Thr Gly Asn Leu Thr Leu Val 
    130                 135                 140                 


Leu Ala Gln Arg Arg Asp Pro Ser Ile His Tyr Ser Pro Gln Phe His 
145                 150                 155                 160 


Lys Val Thr Val Ala Gly Ile Ser Ile Tyr Cys Tyr Ala Trp Leu Val 
                165                 170                 175     


Pro Leu Ala Leu Trp Gly Phe Leu Arg Trp Arg Lys Gly Val Gln Glu 
            180                 185                 190         


Arg Met Gly Pro Tyr Thr Phe Leu Glu Thr Val Cys Ile Tyr Gly Tyr 
        195                 200                 205             


Ser Leu Phe Val Phe Ile Pro Met Val Val Leu Trp Leu Ile Pro Val 
    210                 215                 220                 


Pro Trp Leu Gln Trp Leu Phe Gly Ala Leu Ala Leu Gly Leu Ser Ala 
225                 230                 235                 240 


Ala Gly Leu Val Phe Thr Leu Trp Pro Val Val Arg Glu Asp Thr Arg 
                245                 250                 255     


Leu Val Ala Thr Val Leu Leu Ser Val Val Val Leu Leu His Ala Leu 
            260                 265                 270         


Leu Ala Met Gly Cys Lys Leu Tyr Phe Phe Gln Ser Leu Pro Pro Glu 
        275                 280                 285             


Asn Val Ala Pro Pro Pro Gln Ile Thr Ser Leu Pro Ser Asn Ile Ala 
    290                 295                 300                 


Leu Ser Pro Thr Leu Pro Gln Ser Leu Ala Pro Ser 
305                 310                 315     


<210>  23
<211>  1210
<212>  DNA
<213>  Homo sapiens

<400>  23
aggtgagggg gggcggagcg cacctgtggg gacgggacga cgagttcaag cctccgtggg     60

tgcagttggt cgccagcgag ggatgcggag acgcccctga acgaccatgg catcggccga    120

cgagctgacc ttccatgaat tcgaggaggc cactaatctt ctggctgaca ccccagatgc    180

agccaccacc agcagaagcg atcagctgac cccacaaggg cacgtggctg tggccgtggg    240

ctcaggtggc agctatggag ccgaggatga ggtggaggag gagagtgaca aggccgcgct    300

cctgcaggag cagcagcagc agcagcagcc gggattctgg accttcagct actatcagag    360

cttctttgac gtggacacct cacaggtcct ggaccggatc aaaggctcac tgctgccccg    420

gcctggccac aactttgtgc ggcaccatct gcggaatcgg ccggatctgt atggcccctt    480

ctggatctgt gccacgttgg cctttgtcct ggccgtcact ggcaacctga cgctggtgct    540

ggcccagagg agggacccct ccatccacta cagcccccag ttccacaagg tgaccgtggc    600

aggcatcagc atctactgct atgcgtggct ggtgcccctg gccctgtggg gcttcctgcg    660

gtggcgcaag ggtgtccagg agcgcatggg gccctacacc ttcctggaga ctgtgtgcat    720

ctacggctac tccctctttg tcttcatccc catggtggtc ctgtggctca tccctgtgcc    780

ttggctgcag tggctctttg gggcgctggc cctgggcctg tcagccgccg ggctggtatt    840

caccctctgg cccgtggtcc gtgaggacac caggctggtg gccacagtgc tgctgtccgt    900

ggtcgtgctg ctccacgccc tcctggccat gggctgtaag ttgtacttct tccagtcgct    960

gcctccggag aacgtggctc ctccacccca aatcacatct ctgccctcaa acatcgcgct   1020

gtcccctacc ttgccgcagt ccctggcccc ctcctaggaa ggcccgggtc ccacaggcaa   1080

cacctaagtg gaccaacccc tctgcctgtc ctgcccccca gacgatgact gaaggctcct   1140

ttgacacctt gagatgattc tgctactttc cagacttttc ttacaaagca aacactttta   1200

ttttctatgc                                                          1210


<210>  24
<211>  1502
<212>  DNA
<213>  Homo sapiens

<400>  24
ggatgttgct gtcaggtctg agtcggttgg agtctgacgg gtaggcgaga cgcgcaggcg     60

cagagagccc cagccacgcc ggcccaggtg gcctcagcga gggatgcgga gacgcccctg    120

aacgaccatg gcatcggccg acgagctgac cttccatgaa ttcgaggagg ccactaatct    180

tctggctgac accccagatg cagccaccac cagcagaagc gatcagctga ccccacaagg    240

gcacgtggct gtggccgtgg gctcaggtgg cagctatgga gccgaggatg aggtggagga    300

ggagagtgac aaggccgcgc tcctgcagga gcagcagcag cagcagcagc cgggattctg    360

gaccttcagc tactatcaga gcttctttga cgtggacacc tcacaggtcc tggaccggat    420

caaaggctca ctgctgcccc ggcctggcca caactttgtg cggcaccatc tgcggaatcg    480

gccggatctg tatggcccct tctggatctg tgccacgttg gcctttgtcc tggccgtcac    540

tggcaacctg acgctggtgc tggcccagag gagggacccc tccatccact acagccccca    600

gttccacaag gtgaccgtgg caggcatcag catctactgc tatgcgtggc tggtgcccct    660

ggccctgtgg ggcttcctgc ggtggcgcaa gggtgtccag gagcgcatgg ggccctacac    720

cttcctggag actgtgtgca tctacggcta ctccctcttt gtcttcatcc ccatggtggt    780

cctgtggctc atccctgtgc cttggctgca gtggctcttt ggggcgctgg ccctgggcct    840

gtcagccgcc gggctggtat tcaccctctg gcccgtggtc cgtgaggaca ccaggctggt    900

ggccacagtg ctgctgtccg tggtcgtgct gctccacgcc ctcctggcca tgggctgtaa    960

gttgtacttc ttccagtcgc tgcctccgga gaacgtggct cctccacccc aaatcacatc   1020

tctgccctca aacatcgcgc tgtcccctac cttgccgcag tccctggccc cctcctagga   1080

aggcccgggt cccacaggca acacctaagt ggaccaaccc ctctgcctgt cctgcccccc   1140

agacgatgac tgaaggctcc tttgacacct tgagatgatt ctgctacttt ccagactttt   1200

cttacaaagc aaacactttt attttctatg caaaggtgat tcagagaatt tatataaagg   1260

cgggcgaggg gcagccgagc agggagcttt gggacagggc tggggccccc atatcccccc   1320

cgggccacct gctttccctc ctatggctcc cctggaacag gagggagagc caagggggcg   1380

gcccagcctg gacagcgccc gctcctgcct gggtgcacac acggcgggcc tgagctccag   1440

catctgagtt tgggggtatg agaaacaggg gagcagaagg agaagaaaac tgcctgtgct   1500

gc                                                                  1502


<210>  25
<211>  131
<212>  PRT
<213>  Homo sapiens

<400>  25

Met Phe Leu Gly Leu Val Gly Leu Arg Thr Lys Gly Arg Arg Trp Ile 
1               5                   10                  15      


Ser Ser Trp Ser Glu Gly Glu Asp Arg Gly Gln Ser Pro Glu Gly Val 
            20                  25                  30          


Leu Leu Thr Trp Val Phe Gly Thr Lys Cys Val Met His Pro Cys Glu 
        35                  40                  45              


Glu Thr Thr Lys Gln Ala Leu Cys Glu Gln Gln Gly Cys Leu Phe His 
    50                  55                  60                  


Leu Gly Ala Asp Glu Leu Ser Pro Lys Arg Glu Ser Ala Gln Ser Ile 
65                  70                  75                  80  


Ser Phe Lys Trp Glu Asn Ser Ile Tyr Leu His Ala Thr Leu Phe Leu 
                85                  90                  95      


Ile Gly Glu Tyr Leu His Leu Ala Phe Tyr Tyr Phe Leu Leu Val Leu 
            100                 105                 110         


Tyr Ile Leu Cys Ser Phe Leu Ser Tyr Cys Leu Leu Leu Trp Leu Gly 
        115                 120                 125             


Ser Phe Leu 
    130     


<210>  26
<211>  2950
<212>  DNA
<213>  Homo sapiens

<400>  26
attatctagg tctcggagga tggagaaatc aaaagtgcca ttttctggcc atttagaacc     60

attgtcgagt ttgtattggg gccaagcagt gttgcagaag aaaataagac atttagattt    120

tagttcaggt gatagttgaa gaaattttaa gttcttgaga acacaggcta agggagaaga    180

aggaggaatg gagggtggaa gtttgcccat agtgaaggag gcaagtttaa agagaaaggt    240

agagacatgg agaaagggtt ggggagcagc cctgggctgc aatgtgggtg agcagccaaa    300

gcaggcatcc ccgcaattga cttgccacca agggaatgtg gttgaatgac caaggcaggc    360

atccctgaag atatcagacg ccaatggaat gtgggtgaat aatcaggcag gcatccccgg    420

aatgattaaa cactaaggga aggctgcctt cctgagtaca tgaccagcac cagagttttg    480

ggtccatgga taaaatgtgt ctcctttgtc tctactagaa aatgaaagga attgaaatta    540

agagaagaga gggagtgaag ggtggcacca agaatgaaag gagaaagagg ttgagggata    600

gtgagaaagg ttggagaaga gagtaaaaag aggccactta cccgatttaa aatttgtgag    660

atgttccttg ggctggttgg tctgaggacc aaaggtcgta ggtggatctc ttcatggagt    720

gagggtgagg acaggggaca gtctcctgaa ggagtcctgc tgacctgggt ctttggcacc    780

aaatgtgtca tgcatccatg tgaagagacc accaaacagg ctttgtgtga gcaacagggc    840

tgtttgtttc acctgggtgc agacgagttg agtccaaaaa gagagtcagc ccagtctata    900

tcttttaaat gggaaaattc aatctattta catgcaacgt tattcttgat aggtgagtac    960

ttacatctag cattctatta ttttctgctt gttttgtata tcctttgttc cttcctctct   1020

tactgtttac ttttgtggtt gggcagtttt ctgtagggat aagatttgag tcttatctct   1080

ttctccctat gtgttagctt taccagtgag tttttatagt ttcacatatt tttatgatgc   1140

tggttatcat cttctctgtg gggaacaggc cccccaaaac ctggccataa actggcccca   1200

aaactggcca taaacaaaat ctctgcagca ctgtgacatg tacatgatgg tcttaacgcc   1260

cacgctggaa ggttgtgggt ttaccagaat gagggcaagg aacacctggc ccacccaggg   1320

tggaaaaccg cttaaaggca ttcttaaacc acaaacaata gcatgagtga tctgtgcctt   1380

aaggccatgc tcctgctgca gatagctagt ccaacccatc cctttatttc agcccatctc   1440

ttcatttccc ataaggaata attttagtta atctaatatc tatagaaaga atgctaatga   1500

ctagcttgct gttaataaat acatgggtaa acctctgttg gaggctctca gctctgaagg   1560

ctgtgagacc cttgatttcc tacttcactc ctctatattt ctgtgtcttt aattcctcta   1620

gtgccactgg gttagagtct ccccgaccaa gctggtctca gcaagtggtc tccatcatgg   1680

gggctcgaat ccaggttgaa gggtcaccag agtgatggtt ggagaacatg gaactagctg   1740

gaggacacct gagtactctt aaagcaaacc ccgtggtgag taagaagggg agctcagaag   1800

catcagggta acaatgggac aagtgtgggg tctggttcgt tccatcttgg aactttttca   1860

cactgatgat gaggaagaag gagagtataa tgaagtaaca gaagaggtta tagagcaggt   1920

ttatttgcca gctaaagcta aagtggcaaa ggagggagag gttcatccct acccttctgc   1980

accccctcat tattattttg aagaaaaaga gtggcctgac cctccagatc tttcttttcc   2040

agaggacagt gggcaaaaat tagttgcccc agtgactgtt caagcagcac ctcgagcgac   2100

tgctcttagt tctattcagt caggaattca gcaagctaga tgagaaggtg attaagaggc   2160

ttggcagttc cctgttagac tacactgccc agaccaacag ggaaatattg tagctacatt   2220

tgagcctttt tgttttaaat tactcaaaga atttaaacaa gctattaatc agtatggacc   2280

aggttctcct tttgtaatgg gactattaaa gaacattgct gtttccagtc agatgattcc   2340

tactgactgg gacgctctta ctcaagcttg tctaactcct gcttagttct tacaatttaa   2400

aacttggtgg gcagatgaag cttccattca ggcttctcac aacacgcagg accaacctca   2460

aattaatata actgcagacc aacttttggg ggttggcagt tgggctggtt tagatgcaca   2520

aatggtcatg caggatgatg ccatagaaca gcttagagga gcgtgcatta gagcttgggg   2580

aaaaaaaatc acttcaagtg gagaacaata ccctttcttt agtgctataa aacagggacc   2640

agaagaatca tatgtggatt ttatagctca gttacaggag tctcttaaaa agatgactgc   2700

agatttggct gctcaggata tagtgttgca attattagct ttcaacaatg ctaatcctga   2760

ttgccaggct gctctgtgac ctatcagagg gaaagcacat ttagttgatt atatcaaggc   2820

ctgtggtggt atcagaggta atctgcatca ggccacctgc tagcacgggc aatggcagga   2880

ctgagagtgg atacagaaag tactccattt cctggagctt gttttaactg tgggaagcat   2940

ggtcatactg                                                          2950


<210>  27
<211>  173
<212>  PRT
<213>  Homo sapiens

<400>  27

Met Thr Leu Cys His Arg Asp Ser Phe Gly Ser Trp His Leu Phe His 
1               5                   10                  15      


Leu Leu Leu Leu Glu Tyr Met Ile His Ile Leu Gln Ser Cys Leu Glu 
            20                  25                  30          


Glu Glu Glu Glu Glu Glu Asp Met Gly Thr Val Lys Glu Met Leu Pro 
        35                  40                  45              


Asp Asp Pro Thr Leu Gly Gln Pro Asp Gln Ala Leu Phe His Ser Leu 
    50                  55                  60                  


Asn Ser Ser Leu Ser Gln Ala Cys Ala Ser Pro Ser Met Glu Pro Leu 
65                  70                  75                  80  


Gly Val Met Pro Thr His Met Gly Gln Gly Arg Tyr Pro Val Gly Val 
                85                  90                  95      


Ser Asn Met Val Leu Arg Ile Leu Gly Phe Leu Val Asp Thr Ala Met 
            100                 105                 110         


Gly Asn Lys Leu Ile Gln Val Leu Leu Glu Asp Glu Thr Thr Glu Ser 
        115                 120                 125             


Ala Val Lys Leu Ser Leu Pro Met Gly Gln Glu Ala Leu Ile Thr Leu 
    130                 135                 140                 


Lys Asp Gly Gln Gln Phe Val Ile Gln Ile Ser Asp Val Pro Gln Ser 
145                 150                 155                 160 


Ser Glu Asp Ile Tyr Phe Arg Glu Asn Asn Ala Asn Val 
                165                 170             


<210>  28
<211>  1907
<212>  DNA
<213>  Homo sapiens

<400>  28
ataactccaa cgctcaagca agtcaaggac acccacggac tcaacaccgc gaccagattg     60

gaaaaggtgt tggtcgacaa cttctgcatt tgcgaagagt gcagcgtccc tcgctgtctc    120

atgtatgaga tttacgtgga gacctgtggg caaaacactg agaaccaagt caacccggcc    180

acctttggga agcttgtgag attggttttt ccggaccttg gcacccggag gctgggcact    240

agaggaagtg ccaggtatca ttatgatgga atctgtatca agaaaagctc tttcttctat    300

gcccagtatt gctacctgat aggtgaaaaa aggtatcaca gtggagatgc cattgccttt    360

gaaaaatcta ctaattataa cagcattatc caacaagaag caacatgtga agatcattca    420

ccgatgaaga cagacccagt tggatcccct ttgtctgaat tcaggagatg tccatttctg    480

gagcaagaac aggcaaagaa atactcctgt aatatgatgg ccttccttgc tgacgaatac    540

tgcaactatt gtcgagacat tttacgaaat gtgaggaact gagaacttga gagggtggag    600

gacttgctta cttccttctg gaagtctctg cagcaagaca cagtcatgct gatgtcattg    660

cctgacgtgt gccagctctt taaatgctac gacgtccagc tgtacaaggg aattgaggat    720

gttctccttc atgacttctt ggaagatgtt tctattcagt acctgaaatc tgtgcagtta    780

tttagtaaga aatttaagct gtggctcctt aatgctttgg aaggtgttcc agccctcttg    840

cagatctcca aactcaaaga ctatgcgaat ggtattgaaa agtaagaggc gtgtcagcgt    900

tttgaagtca gatctacagg ccatcatcaa tcaaggcact ttggctactt ctaagaaagc    960

cctggcaagt gaccggagtg gcgcagatga actggagaac aacccagaga tgaaatgttt   1020

aagaaactta atttctttgc tgggaacatc aacagatctc agggtattcc tcagctgtct   1080

gtcttcacat ctccaagcat ttgtgttcca gacaagcaga agcaaagaag agtttaccaa   1140

attggccgcc agcttccagc tgagatggaa tcttcttctc actgctgtaa gcaaagccat   1200

gaccctctgc cacagagata gttttggctc ctggcatctg tttcacttgt tgcttttgga   1260

atatatgatt catatacttc agtcatgcct agaggaggaa gaggaggagg aggacatggg   1320

gactgtcaag gaaatgctac cagatgaccc gactctcggc cagccagacc aggcactttt   1380

ccattctctg aattcctcac tgtcgcaggc gtgtgccagc cccagcatgg agccactggg   1440

ggtgatgccc acacacatgg gccagggccg atatcccgtg ggtgtgagca acatggtcct   1500

caggatcctg ggcttcctgg tggacactgc catgggcaat aagctcatcc aggtgctgtt   1560

ggaagatgaa accactgaaa gcgcagttaa actcagcctt cctatgggac aagaagccct   1620

cataacccta aaagatggac aacaatttgt gattcagata tcagatgtac cccaaagctc   1680

tgaagatatt tatttcagag aaaacaatgc taatgtgtga gattatttat ttgaatagag   1740

aataagaaaa ctgatagact tgcattctta aaaatattaa atactaaagt ttttctattg   1800

acgaaagatg atgttatgta tataatagat gtagcattgt ctattttatg tttatatgta   1860

tttcaaggag gtggtttcga taaaatatgt aaactgattt ggagaat                 1907


<210>  29
<211>  458
<212>  PRT
<213>  Homo sapiens

<400>  29

Met Glu Gly Ser Ala Ser Pro Pro Glu Lys Pro Arg Ala Arg Pro Ala 
1               5                   10                  15      


Ala Ala Val Leu Cys Arg Gly Pro Val Glu Pro Leu Val Phe Leu Ala 
            20                  25                  30          


Asn Phe Ala Leu Val Leu Gln Gly Pro Leu Thr Thr Gln Tyr Leu Trp 
        35                  40                  45              


His Arg Phe Ser Ala Asp Leu Gly Tyr Asn Gly Thr Arg Gln Arg Gly 
    50                  55                  60                  


Gly Cys Ser Asn Arg Ser Ala Asp Pro Thr Met Gln Glu Val Glu Thr 
65                  70                  75                  80  


Leu Thr Ser His Trp Thr Leu Tyr Met Asn Val Gly Gly Phe Leu Val 
                85                  90                  95      


Gly Leu Phe Ser Ser Thr Leu Leu Gly Ala Trp Ser Asp Ser Val Gly 
            100                 105                 110         


Arg Arg Pro Leu Leu Val Leu Ala Ser Leu Gly Leu Leu Leu Gln Ala 
        115                 120                 125             


Leu Val Ser Val Phe Val Val Gln Leu Gln Leu His Val Gly Tyr Phe 
    130                 135                 140                 


Val Leu Gly Arg Ile Leu Cys Ala Leu Leu Gly Asp Phe Gly Gly Leu 
145                 150                 155                 160 


Leu Ala Ala Ser Phe Ala Ser Val Ala Asp Val Ser Ser Ser Arg Ser 
                165                 170                 175     


Arg Thr Phe Arg Met Ala Leu Leu Glu Ala Ser Ile Gly Val Ala Gly 
            180                 185                 190         


Met Leu Ala Ser Leu Leu Gly Gly His Trp Leu Arg Ala Gln Gly Tyr 
        195                 200                 205             


Ala Asn Pro Phe Trp Leu Ala Leu Ala Leu Leu Ile Ala Met Thr Leu 
    210                 215                 220                 


Tyr Ala Ala Phe Cys Phe Gly Glu Thr Leu Lys Glu Pro Lys Ser Thr 
225                 230                 235                 240 


Arg Leu Phe Thr Phe Arg His His Arg Ser Ile Val Gln Leu Tyr Val 
                245                 250                 255     


Ala Pro Ala Pro Glu Lys Ser Arg Lys His Leu Ala Leu Tyr Ser Leu 
            260                 265                 270         


Ala Ile Phe Val Val Ile Thr Val His Phe Gly Ala Gln Asp Ile Leu 
        275                 280                 285             


Thr Leu Tyr Glu Leu Ser Thr Pro Leu Cys Trp Asp Ser Lys Leu Ile 
    290                 295                 300                 


Gly Tyr Gly Ser Ala Ala Gln His Leu Pro Tyr Leu Thr Ser Leu Leu 
305                 310                 315                 320 


Ala Leu Lys Leu Leu Gln Tyr Cys Leu Ala Asp Ala Trp Val Ala Glu 
                325                 330                 335     


Ile Gly Leu Ala Phe Asn Ile Leu Gly Met Val Val Phe Ala Phe Ala 
            340                 345                 350         


Thr Ile Thr Pro Leu Met Phe Thr Gly Tyr Gly Leu Leu Phe Leu Ser 
        355                 360                 365             


Leu Val Ile Thr Pro Val Ile Arg Ala Lys Leu Ser Lys Leu Val Arg 
    370                 375                 380                 


Glu Thr Glu Gln Gly Ala Leu Phe Ser Ala Val Ala Cys Val Asn Ser 
385                 390                 395                 400 


Leu Ala Met Leu Thr Ala Ser Gly Phe Asn Ser Leu Tyr Pro Ala Thr 
                405                 410                 415     


Leu Asn Phe Met Lys Gly Phe Pro Phe Leu Leu Gly Ala Gly Leu Leu 
            420                 425                 430         


Leu Ile Pro Ala Val Leu Ile Gly Met Leu Glu Lys Ala Asp Pro His 
        435                 440                 445             


Leu Glu Phe Gln Gln Phe Pro Gln Ser Pro 
    450                 455             


<210>  30
<211>  430
<212>  PRT
<213>  Homo sapiens

<400>  30

Met Glu Gly Ser Ala Ser Pro Pro Glu Lys Pro Arg Ala Arg Pro Ala 
1               5                   10                  15      


Ala Ala Val Leu Cys Arg Gly Pro Val Glu Pro Leu Val Phe Leu Ala 
            20                  25                  30          


Asn Phe Ala Leu Val Leu Gln Gly Pro Leu Thr Thr Gln Tyr Leu Trp 
        35                  40                  45              


His Arg Phe Ser Ala Asp Leu Gly Tyr Asn Gly Thr Arg Gln Arg Gly 
    50                  55                  60                  


Gly Cys Ser Asn Arg Ser Ala Asp Pro Thr Met Gln Glu Val Glu Thr 
65                  70                  75                  80  


Leu Thr Ser His Trp Thr Leu Tyr Met Asn Val Gly Gly Phe Leu Val 
                85                  90                  95      


Gly Leu Phe Ser Ser Thr Leu Leu Gly Ala Trp Ser Asp Ser Val Gly 
            100                 105                 110         


Arg Arg Pro Leu Leu Val Leu Ala Ser Leu Gly Leu Leu Leu Gln Ala 
        115                 120                 125             


Leu Val Ser Val Phe Val Val Gln Leu Gln Leu His Val Gly Tyr Phe 
    130                 135                 140                 


Val Leu Gly Arg Ile Leu Cys Ala Leu Leu Gly Asp Phe Gly Gly Leu 
145                 150                 155                 160 


Leu Ala Ala Ser Phe Ala Ser Val Ala Asp Val Ser Ser Ser Arg Ser 
                165                 170                 175     


Arg Thr Phe Arg Met Ala Leu Leu Glu Ala Ser Ile Gly Val Ala Gly 
            180                 185                 190         


Met Leu Ala Ser Leu Leu Gly Gly His Trp Leu Arg Ala Gln Gly Tyr 
        195                 200                 205             


Ala Asn Pro Phe Trp Leu Ala Leu Ala Leu Leu Ile Ala Met Thr Leu 
    210                 215                 220                 


Tyr Ala Ala Phe Cys Phe Gly Glu Thr Leu Lys Glu Pro Lys Ser Thr 
225                 230                 235                 240 


Arg Leu Phe Thr Phe Arg His His Arg Ser Ile Val Gln Leu Tyr Val 
                245                 250                 255     


Ala Pro Ala Pro Glu Lys Ser Arg Lys His Leu Ala Leu Tyr Ser Leu 
            260                 265                 270         


Ala Ile Phe Val Val Ile Thr Val His Phe Gly Ala Gln Asp Ile Leu 
        275                 280                 285             


Thr Leu Tyr Glu Leu Ser Thr Pro Leu Cys Trp Asp Ser Lys Leu Ile 
    290                 295                 300                 


Gly Tyr Gly Ser Ala Ala Gln His Leu Pro Tyr Leu Thr Ser Leu Leu 
305                 310                 315                 320 


Ala Leu Lys Leu Leu Gln Tyr Cys Leu Ala Asp Ala Trp Val Ala Glu 
                325                 330                 335     


Ile Gly Leu Ala Phe Asn Ile Leu Gly Met Val Val Phe Ala Phe Ala 
            340                 345                 350         


Thr Ile Thr Pro Leu Met Phe Thr Gly Ala Leu Phe Ser Ala Val Ala 
        355                 360                 365             


Cys Val Asn Ser Leu Ala Met Leu Thr Ala Ser Gly Phe Asn Ser Leu 
    370                 375                 380                 


Tyr Pro Ala Thr Leu Asn Phe Met Lys Gly Phe Pro Phe Leu Leu Gly 
385                 390                 395                 400 


Ala Gly Leu Leu Leu Ile Pro Ala Val Leu Ile Gly Met Leu Glu Lys 
                405                 410                 415     


Ala Asp Pro His Leu Glu Phe Gln Gln Phe Pro Gln Ser Pro 
            420                 425                 430 


<210>  31
<211>  6484
<212>  DNA
<213>  Homo sapiens

<400>  31
acagcgcaag ccccacgcca cgcgtcgctg gtcccaggca gcgagtcgct cgcgcgcccc     60

gccgcccgcc tggcgacagc tccgccgcgc acgcacatgg aggggagcgc gagccccccg    120

gaaaagcccc gcgcccgccc tgcggctgcc gtgctgtgcc ggggcccggt agagccgctg    180

gtcttcctgg ccaactttgc cttggtcctg cagggcccgc tcaccacgca gtatctgtgg    240

caccgcttca gcgccgacct cggctacaat ggcacccgcc aaaggggggg ctgcagcaac    300

cgcagcgcgg accccaccat gcaggaagtg gagaccctta cctcccactg gaccctctac    360

atgaacgtgg gcggcttcct ggtggggctc ttctcgtcca ccctgctggg agcttggagc    420

gacagtgtgg gccgccgccc gctgctagtg ctggcctcgc tgggcctgct gctccaggcc    480

ctagtgtccg tttttgtggt gcagctgcag ctccacgtcg gctacttcgt gctgggtcgc    540

atcctttgtg ccctcctcgg cgacttcggt ggccttctgg ctgctagctt tgcgtccgtg    600

gcagatgtca gctccagtcg cagccgcacc ttccggatgg ccctgctgga agccagcatc    660

ggggtggctg ggatgctggc aagcctcctc gggggccact ggctccgggc ccagggttat    720

gccaacccct tctggctggc cttggccttg ctgatagcca tgactctcta tgcagctttc    780

tgctttggtg agaccttaaa ggagccaaag tccacccggc tcttcacgtt ccgtcaccac    840

cgatccattg tccagctcta tgtggctccc gccccagaga agtccaggaa acatttagcc    900

ctctactcac tggccatctt cgtggtgatc actgtgcact ttggggccca ggacatctta    960

accctttatg aactaagcac acccctctgc tgggactcca aactaatcgg ctatggttct   1020

gcagctcagc atctccccta cctcaccagc ctgctggccc tgaagctcct gcagtactgc   1080

ctggccgatg cctgggtagc tgagatcggc ctggccttca acatcctggg gatggtggtc   1140

tttgcctttg ccactatcac gcctctcatg ttcacaggat atgggttgct tttcctgtca   1200

ttagtcatca cacctgtcat ccgggctaaa ctctccaagc tggtgagaga gacagagcag   1260

ggtgctctct tttctgctgt ggcctgtgtg aatagcctgg ccatgctgac ggcctccggc   1320

ttcaactcac tctacccagc cactctgaac tttatgaagg ggttcccctt cctcctggga   1380

gctggcctcc tgctcatccc ggctgttctg attgggatgc tggaaaaggc tgatcctcac   1440

ctcgagttcc agcagtttcc ccagagcccc tgatctgcct ggaccagaag acagagggca   1500

agaggagcaa agtgaacacc aagcaactgg aggtctgcag ctggaagccc agcccacagc   1560

aggacaagca actcttgtct aagggcagtg ctctctttgg acgaggtagt caagagagac   1620

caaggcacca ccccatccac agctgaccca gcctctgtct aggatctaga atcataaccc   1680

acacaggccc actgcaggac aggtggcaga ggagctattt gggacaggag tcagttctcc   1740

ctttctgcta tccatcactt ataaccccac aggccagagg agaggtcctg agagaggtga   1800

cacttcaggg accagaggca gcacgagggc tggcatctct ccttccagcc caaactgcac   1860

agccccaacc aggttcccaa cacgtgtagc agtcatcagc cattccttaa caatgaatgt   1920

ggtacctggt tagtgccagc cttgggaagg agggagggag gtaagagggg cttggtgatc   1980

tctggaggaa gagtgttgcc tttgctgtgg ttggggaatc gatccttggc tatggcctac   2040

ccactcccct ggctgaagag tgccaatcat tacaaatcag cttcagcaaa ctgaaacaaa   2100

ccttctggtg ccttgggctt tggggccctc tgttttcctg ctcccagtct gcctgccata   2160

cgttagacaa cagaagctgc tgggctgggc aggagccctg agctgcctgg tggattggta   2220

ccaagtgggg ccagccaggg cttctactga ctcgctgtgc aaccttgagc aagccccact   2280

aggaacggct agatcagcaa tgccccaaat tgttgaatcg tggtgatcac atttggatgg   2340

acaagttagg aaacttagct gattctctga gatacttccc acttcctcat acattctaca   2400

atgagatgcc tctcttcatg ggcctgggga aaggatgaat gagtgtggct ggacttttga   2460

cctttaatgt ccctgagcag ttcttggccc ttggggagaa gtagggggag gatctggctg   2520

actcagcccc aaccgagggg tagcagctgc agcccagcca agcagaacac cctggcccta   2580

cagacctgtg tctgagcagg ctttggagga aaggccactt ctgagtcctc tgtctcagga   2640

gaagccaggc ctaggtgctt gacctggtga tctgagctgt gtttgtccta gtatgggtgg   2700

cagtcacctc tgaacacact ggccttggct tagaggaggc ttgtgacttc agctgttcca   2760

gctggggctg gatgctggac tctgattccc tcagagagac agaagatcgg gcagaggtca   2820

accagaaggc cacacagggc agtggacaac agtggagggt ataccaaata gaaataaaac   2880

gcaggaaacc tctctgaata ctgcccttgg ggacctcagg agggagtggg actgattgga   2940

gacaaagagc cagaaatcat cccctggaga tactcagaca ctgtattgtt attggcgctg   3000

tcctgtgagg gcagtgtcca ggctgccctg cttgtcatat ccatgccctg gctctggccc   3060

cggtgagcac ttgtgctgca tgaggaaagg aggatcaggt ggggtcaaaa ccaaagcatc   3120

gaggctggca ctggccaaga cagactctgg cagggagggg agtggaagga aggagcccca   3180

aacctggagt gagacctttg actttctgat gatgtggcca agaactagga gtcacctggc   3240

cagcacagcc aagagtgggg ctgggggcgc cagctttaag gtgtcaacac ctggcccttg   3300

cggggaaaga gccttcagca gcccccacgg cctggagcct gggtttattg gagggtgctt   3360

tcttaccctc tgaacccagt ggaggagggg gcaatgggat attcctgctc tgtatggcct   3420

ctgggtcagc tttttgttgc aaaatcctat cccccgctgc tagattcttt gaagcaaggg   3480

agaagcaata gcccagcctc agaatgattc tcaggaaagc aattccactg ccagtggact   3540

gggtgccagg aggcctaggt ctggatctgg ggctgccact aatgacagga aagtgggctt   3600

atcctcaacc tttctgagcc tcagtgtcat tatctgtaaa atggggatga taataccagg   3660

tagagttgct ctgatgactg gagaccatgg agcggagtgt ttgggaaatg gcaaagattt   3720

gtgagggctt cgtgctttag agatttgcta cccttaacca ccagcatcag ctcacctggg   3780

aatctgtaag aaatgcagag tcctaggccc caccccagat ctcctgattt taacaacatt   3840

cccaggtgac ttggatgcat gttaaagttg gagaagctgc cctaagtgac aaccctttgc   3900

cttttcagga ctttgcctct ttccacagag ctgcaggttc tgtctaggct gcttttactg   3960

ccatgggggc tgcctggtcc ctgagtaagc agtgggtagc cctggatggc tgaggggctg   4020

gggaagccag ctgggccaga ccaggaagga gcctgaggca cagcaccaag gcatggggta   4080

gggtgggctt tgaggcacgg cctccccatg cccagaccca ggcccaaaca ggaggctcct   4140

gtgcaccagc aagtgcagca aagctggctg cagtgacaag gaagtcagag ggagggctgg   4200

tttgcctcaa ccctcgccct ggatgtggca aaagatacca caccgaagga agctgtaggg   4260

gatctgggac ttagtcaggc tagctaaggg cactgagtga ttacagggca aggccacaga   4320

gcggcaggaa gttgtaagtg caggggccag gcacagtctg agtggagagc catgatggca   4380

ctcatccctg gctggctcct gggcccaggc ctttgctcag aatacagtgc ccaggcccgc   4440

ctgggcattg ccttaattcc tgtctgaggc tgccttcctt catcctcctc aagctgactg   4500

ctatcagcag gagaagggaa tgcagaacca cccccacccc aactccagtg tctccagaac   4560

tgagcaggga ccctccccat gacggagaca gacaacccaa tggcagggcc tgggggagtt   4620

ctaacctccc gtgcccaagc ctgacttccc ttccctctcc agatactgag gaaagtgggt   4680

tggaggtggg ccatgagggt gggggacagg gggagggaga gccatttcct aagaagagcc   4740

caggttgtct cagcccaggg agactggttt caggagctgt tccttcagaa aggacgatgg   4800

aaatggaagt cacagcaggg ctggggaact ggggactggt taggttggac ccatgggtgc   4860

agcaccctcc aaactggtgt cagagcctgc agatgagtcc cgggaggagc ggccctgcag   4920

gaagcggatg atcttctcaa tggtggcctc ctggtattcg tgggaccacc tgtgggcaca   4980

ggagccaatg tggttcagac agctgggcag agggagctgc tagtcagctg tttgcccaca   5040

ctctgcctgt catggtgatt tgtaccctac ccccctggtc ccagggccct ggggctcact   5100

tgataccgtt gaaagtaagc acagcctgca tgtcctcagg caggacctgg ggctcaggcc   5160

actcgaagcc atcaatgatg ggcacaatgt tcttgccgca gcttaaagca gtcacaatct   5220

cctggagaaa gaaaggaaag gaggaagata cccctgtacc catctaggga cccttgtagc   5280

caggcaggtg ctgggaggcc cactggcccg aggctgggcc cagggcagga caccagtcct   5340

gatgtccacc ttgatgtcta ccttaaccct tgtagtgtaa taaaaaataa atatttttcc   5400

tttgcccaga gttcctggca cagagctgct aaaacccttg gaatctcttg agtgatgagt   5460

gtctttgtat gctaaagaga tgattcccca ctgggggccc ggggggtgct atgggggtag   5520

cctagatagt ttcaggaaga gggctggtca ccagggagac cagggcatga ctagaggatt   5580

ggaactttca gccccacctc ccagcctcca gagaggtgct ggagattgag ttcaatcacc   5640

aatggccaat gatttaatca atcatgccta cataatggaa cctccataaa aacccccaaa   5700

caaggggttt tgaagagcct ccaggttgat aaacaggtgt aggtgctggg aaggtggtag   5760

aaggcatggc atccacacct ccaccctcca tacgtagaga tcctatgtat ctcttccatt   5820

tggctattct tgagctgtgt cctttataac tgtgaaatta aataattcag ctgggcatgg   5880

tgggtcacgc ctgtaatccc aacactttgg gaggctgagg caggaggatc acttgagccc   5940

aggattttga gattaataat attatttatt actattattc aagctttgtt aaatcaaacc   6000

taaagctctt ggaactttaa gttattctga gccttgacag gaattggtct ctgcagcctg   6060

agtcatgggg catgcagctg caacttccac ctattttttt tttttctgta attacttagg   6120

aagaccaaat ggcaccagag ataagactcc cttagatccc cacttagatc accacccttt   6180

ctcagggggt aataaagtca tcttccttgg aatgtagcaa tctataacca atcaaagcac   6240

tgtaacatac gcactggtct tgtatggaaa atgttgtaat cctgctaaaa ttcctctctc   6300

tttgcctgtg gaagtgaaac cttaacttct ccagtttgga atgctcaccc catgcctttg   6360

gagtcaatgc ttactgggtg gctattctca aactttgcac tcaaagaaac tctatactta   6420

gtcttatttt ctgaatctca ttatttaagg ttgacataat aaacaactaa tagtaagtaa   6480

agtg                                                                6484


<210>  32
<211>  6400
<212>  DNA
<213>  Homo sapiens

<400>  32
acagcgcaag ccccacgcca cgcgtcgctg gtcccaggca gcgagtcgct cgcgcgcccc     60

gccgcccgcc tggcgacagc tccgccgcgc acgcacatgg aggggagcgc gagccccccg    120

gaaaagcccc gcgcccgccc tgcggctgcc gtgctgtgcc ggggcccggt agagccgctg    180

gtcttcctgg ccaactttgc cttggtcctg cagggcccgc tcaccacgca gtatctgtgg    240

caccgcttca gcgccgacct cggctacaat ggcacccgcc aaaggggggg ctgcagcaac    300

cgcagcgcgg accccaccat gcaggaagtg gagaccctta cctcccactg gaccctctac    360

atgaacgtgg gcggcttcct ggtggggctc ttctcgtcca ccctgctggg agcttggagc    420

gacagtgtgg gccgccgccc gctgctagtg ctggcctcgc tgggcctgct gctccaggcc    480

ctagtgtccg tttttgtggt gcagctgcag ctccacgtcg gctacttcgt gctgggtcgc    540

atcctttgtg ccctcctcgg cgacttcggt ggccttctgg ctgctagctt tgcgtccgtg    600

gcagatgtca gctccagtcg cagccgcacc ttccggatgg ccctgctgga agccagcatc    660

ggggtggctg ggatgctggc aagcctcctc gggggccact ggctccgggc ccagggttat    720

gccaacccct tctggctggc cttggccttg ctgatagcca tgactctcta tgcagctttc    780

tgctttggtg agaccttaaa ggagccaaag tccacccggc tcttcacgtt ccgtcaccac    840

cgatccattg tccagctcta tgtggctccc gccccagaga agtccaggaa acatttagcc    900

ctctactcac tggccatctt cgtggtgatc actgtgcact ttggggccca ggacatctta    960

accctttatg aactaagcac acccctctgc tgggactcca aactaatcgg ctatggttct   1020

gcagctcagc atctccccta cctcaccagc ctgctggccc tgaagctcct gcagtactgc   1080

ctggccgatg cctgggtagc tgagatcggc ctggccttca acatcctggg gatggtggtc   1140

tttgcctttg ccactatcac gcctctcatg ttcacaggtg ctctcttttc tgctgtggcc   1200

tgtgtgaata gcctggccat gctgacggcc tccggcttca actcactcta cccagccact   1260

ctgaacttta tgaaggggtt ccccttcctc ctgggagctg gcctcctgct catcccggct   1320

gttctgattg ggatgctgga aaaggctgat cctcacctcg agttccagca gtttccccag   1380

agcccctgat ctgcctggac cagaagacag agggcaagag gagcaaagtg aacaccaagc   1440

aactggaggt ctgcagctgg aagcccagcc cacagcagga caagcaactc ttgtctaagg   1500

gcagtgctct ctttggacga ggtagtcaag agagaccaag gcaccacccc atccacagct   1560

gacccagcct ctgtctagga tctagaatca taacccacac aggcccactg caggacaggt   1620

ggcagaggag ctatttggga caggagtcag ttctcccttt ctgctatcca tcacttataa   1680

ccccacaggc cagaggagag gtcctgagag aggtgacact tcagggacca gaggcagcac   1740

gagggctggc atctctcctt ccagcccaaa ctgcacagcc ccaaccaggt tcccaacacg   1800

tgtagcagtc atcagccatt ccttaacaat gaatgtggta cctggttagt gccagccttg   1860

ggaaggaggg agggaggtaa gaggggcttg gtgatctctg gaggaagagt gttgcctttg   1920

ctgtggttgg ggaatcgatc cttggctatg gcctacccac tcccctggct gaagagtgcc   1980

aatcattaca aatcagcttc agcaaactga aacaaacctt ctggtgcctt gggctttggg   2040

gccctctgtt ttcctgctcc cagtctgcct gccatacgtt agacaacaga agctgctggg   2100

ctgggcagga gccctgagct gcctggtgga ttggtaccaa gtggggccag ccagggcttc   2160

tactgactcg ctgtgcaacc ttgagcaagc cccactagga acggctagat cagcaatgcc   2220

ccaaattgtt gaatcgtggt gatcacattt ggatggacaa gttaggaaac ttagctgatt   2280

ctctgagata cttcccactt cctcatacat tctacaatga gatgcctctc ttcatgggcc   2340

tggggaaagg atgaatgagt gtggctggac ttttgacctt taatgtccct gagcagttct   2400

tggcccttgg ggagaagtag ggggaggatc tggctgactc agccccaacc gaggggtagc   2460

agctgcagcc cagccaagca gaacaccctg gccctacaga cctgtgtctg agcaggcttt   2520

ggaggaaagg ccacttctga gtcctctgtc tcaggagaag ccaggcctag gtgcttgacc   2580

tggtgatctg agctgtgttt gtcctagtat gggtggcagt cacctctgaa cacactggcc   2640

ttggcttaga ggaggcttgt gacttcagct gttccagctg gggctggatg ctggactctg   2700

attccctcag agagacagaa gatcgggcag aggtcaacca gaaggccaca cagggcagtg   2760

gacaacagtg gagggtatac caaatagaaa taaaacgcag gaaacctctc tgaatactgc   2820

ccttggggac ctcaggaggg agtgggactg attggagaca aagagccaga aatcatcccc   2880

tggagatact cagacactgt attgttattg gcgctgtcct gtgagggcag tgtccaggct   2940

gccctgcttg tcatatccat gccctggctc tggccccggt gagcacttgt gctgcatgag   3000

gaaaggagga tcaggtgggg tcaaaaccaa agcatcgagg ctggcactgg ccaagacaga   3060

ctctggcagg gaggggagtg gaaggaagga gccccaaacc tggagtgaga cctttgactt   3120

tctgatgatg tggccaagaa ctaggagtca cctggccagc acagccaaga gtggggctgg   3180

gggcgccagc tttaaggtgt caacacctgg cccttgcggg gaaagagcct tcagcagccc   3240

ccacggcctg gagcctgggt ttattggagg gtgctttctt accctctgaa cccagtggag   3300

gagggggcaa tgggatattc ctgctctgta tggcctctgg gtcagctttt tgttgcaaaa   3360

tcctatcccc cgctgctaga ttctttgaag caagggagaa gcaatagccc agcctcagaa   3420

tgattctcag gaaagcaatt ccactgccag tggactgggt gccaggaggc ctaggtctgg   3480

atctggggct gccactaatg acaggaaagt gggcttatcc tcaacctttc tgagcctcag   3540

tgtcattatc tgtaaaatgg ggatgataat accaggtaga gttgctctga tgactggaga   3600

ccatggagcg gagtgtttgg gaaatggcaa agatttgtga gggcttcgtg ctttagagat   3660

ttgctaccct taaccaccag catcagctca cctgggaatc tgtaagaaat gcagagtcct   3720

aggccccacc ccagatctcc tgattttaac aacattccca ggtgacttgg atgcatgtta   3780

aagttggaga agctgcccta agtgacaacc ctttgccttt tcaggacttt gcctctttcc   3840

acagagctgc aggttctgtc taggctgctt ttactgccat gggggctgcc tggtccctga   3900

gtaagcagtg ggtagccctg gatggctgag gggctgggga agccagctgg gccagaccag   3960

gaaggagcct gaggcacagc accaaggcat ggggtagggt gggctttgag gcacggcctc   4020

cccatgccca gacccaggcc caaacaggag gctcctgtgc accagcaagt gcagcaaagc   4080

tggctgcagt gacaaggaag tcagagggag ggctggtttg cctcaaccct cgccctggat   4140

gtggcaaaag ataccacacc gaaggaagct gtaggggatc tgggacttag tcaggctagc   4200

taagggcact gagtgattac agggcaaggc cacagagcgg caggaagttg taagtgcagg   4260

ggccaggcac agtctgagtg gagagccatg atggcactca tccctggctg gctcctgggc   4320

ccaggccttt gctcagaata cagtgcccag gcccgcctgg gcattgcctt aattcctgtc   4380

tgaggctgcc ttccttcatc ctcctcaagc tgactgctat cagcaggaga agggaatgca   4440

gaaccacccc caccccaact ccagtgtctc cagaactgag cagggaccct ccccatgacg   4500

gagacagaca acccaatggc agggcctggg ggagttctaa cctcccgtgc ccaagcctga   4560

cttcccttcc ctctccagat actgaggaaa gtgggttgga ggtgggccat gagggtgggg   4620

gacaggggga gggagagcca tttcctaaga agagcccagg ttgtctcagc ccagggagac   4680

tggtttcagg agctgttcct tcagaaagga cgatggaaat ggaagtcaca gcagggctgg   4740

ggaactgggg actggttagg ttggacccat gggtgcagca ccctccaaac tggtgtcaga   4800

gcctgcagat gagtcccggg aggagcggcc ctgcaggaag cggatgatct tctcaatggt   4860

ggcctcctgg tattcgtggg accacctgtg ggcacaggag ccaatgtggt tcagacagct   4920

gggcagaggg agctgctagt cagctgtttg cccacactct gcctgtcatg gtgatttgta   4980

ccctaccccc ctggtcccag ggccctgggg ctcacttgat accgttgaaa gtaagcacag   5040

cctgcatgtc ctcaggcagg acctggggct caggccactc gaagccatca atgatgggca   5100

caatgttctt gccgcagctt aaagcagtca caatctcctg gagaaagaaa ggaaaggagg   5160

aagatacccc tgtacccatc tagggaccct tgtagccagg caggtgctgg gaggcccact   5220

ggcccgaggc tgggcccagg gcaggacacc agtcctgatg tccaccttga tgtctacctt   5280

aacccttgta gtgtaataaa aaataaatat ttttcctttg cccagagttc ctggcacaga   5340

gctgctaaaa cccttggaat ctcttgagtg atgagtgtct ttgtatgcta aagagatgat   5400

tccccactgg gggcccgggg ggtgctatgg gggtagccta gatagtttca ggaagagggc   5460

tggtcaccag ggagaccagg gcatgactag aggattggaa ctttcagccc cacctcccag   5520

cctccagaga ggtgctggag attgagttca atcaccaatg gccaatgatt taatcaatca   5580

tgcctacata atggaacctc cataaaaacc cccaaacaag gggttttgaa gagcctccag   5640

gttgataaac aggtgtaggt gctgggaagg tggtagaagg catggcatcc acacctccac   5700

cctccatacg tagagatcct atgtatctct tccatttggc tattcttgag ctgtgtcctt   5760

tataactgtg aaattaaata attcagctgg gcatggtggg tcacgcctgt aatcccaaca   5820

ctttgggagg ctgaggcagg aggatcactt gagcccagga ttttgagatt aataatatta   5880

tttattacta ttattcaagc tttgttaaat caaacctaaa gctcttggaa ctttaagtta   5940

ttctgagcct tgacaggaat tggtctctgc agcctgagtc atggggcatg cagctgcaac   6000

ttccacctat tttttttttt tctgtaatta cttaggaaga ccaaatggca ccagagataa   6060

gactccctta gatccccact tagatcacca ccctttctca gggggtaata aagtcatctt   6120

ccttggaatg tagcaatcta taaccaatca aagcactgta acatacgcac tggtcttgta   6180

tggaaaatgt tgtaatcctg ctaaaattcc tctctctttg cctgtggaag tgaaacctta   6240

acttctccag tttggaatgc tcaccccatg cctttggagt caatgcttac tgggtggcta   6300

ttctcaaact ttgcactcaa agaaactcta tacttagtct tattttctga atctcattat   6360

ttaaggttga cataataaac aactaatagt aagtaaagtg                         6400


<210>  33
<211>  402
<212>  PRT
<213>  Homo sapiens

<400>  33

Met Met Val Ala Leu Arg Gly Ala Ser Ala Leu Leu Val Leu Phe Leu 
1               5                   10                  15      


Ala Ala Phe Leu Pro Pro Pro Gln Cys Thr Gln Asp Pro Ala Met Val 
            20                  25                  30          


His Tyr Ile Tyr Gln Arg Phe Arg Val Leu Glu Gln Gly Leu Glu Lys 
        35                  40                  45              


Cys Thr Gln Ala Thr Arg Ala Tyr Ile Gln Glu Phe Gln Glu Phe Ser 
    50                  55                  60                  


Lys Asn Ile Ser Val Met Leu Gly Arg Cys Gln Thr Tyr Thr Ser Glu 
65                  70                  75                  80  


Tyr Lys Ser Ala Val Gly Asn Leu Ala Leu Arg Val Glu Arg Ala Gln 
                85                  90                  95      


Arg Glu Ile Asp Tyr Ile Gln Tyr Leu Arg Glu Ala Asp Glu Cys Ile 
            100                 105                 110         


Glu Ser Glu Asp Lys Thr Leu Ala Glu Met Leu Leu Gln Glu Ala Glu 
        115                 120                 125             


Glu Glu Lys Lys Ile Arg Thr Leu Leu Asn Ala Ser Cys Asp Asn Met 
    130                 135                 140                 


Leu Met Gly Ile Lys Ser Leu Lys Ile Val Lys Lys Met Met Asp Thr 
145                 150                 155                 160 


His Gly Ser Trp Met Lys Asp Ala Val Tyr Asn Ser Pro Lys Val Tyr 
                165                 170                 175     


Leu Leu Ile Gly Ser Arg Asn Asn Thr Val Trp Glu Phe Ala Asn Ile 
            180                 185                 190         


Arg Ala Phe Met Glu Asp Asn Thr Lys Pro Ala Pro Arg Lys Gln Ile 
        195                 200                 205             


Leu Thr Leu Ser Trp Gln Gly Thr Gly Gln Val Ile Tyr Lys Gly Phe 
    210                 215                 220                 


Leu Phe Phe His Asn Gln Ala Thr Ser Asn Glu Ile Ile Lys Tyr Asn 
225                 230                 235                 240 


Leu Gln Lys Arg Thr Val Glu Asp Arg Met Leu Leu Pro Gly Gly Val 
                245                 250                 255     


Gly Arg Ala Leu Val Tyr Gln His Ser Pro Ser Thr Tyr Ile Asp Leu 
            260                 265                 270         


Ala Val Asp Glu His Gly Leu Trp Ala Ile His Ser Gly Pro Gly Thr 
        275                 280                 285             


His Ser His Leu Val Leu Thr Lys Ile Glu Pro Gly Thr Leu Gly Val 
    290                 295                 300                 


Glu His Ser Trp Asp Thr Pro Cys Arg Ser Gln Asp Ala Glu Ala Ser 
305                 310                 315                 320 


Phe Leu Leu Cys Gly Val Leu Tyr Val Val Tyr Ser Thr Gly Gly Gln 
                325                 330                 335     


Gly Pro His Arg Ile Thr Cys Ile Tyr Asp Pro Leu Gly Thr Ile Ser 
            340                 345                 350         


Glu Glu Asp Leu Pro Asn Leu Phe Phe Pro Lys Arg Pro Arg Ser His 
        355                 360                 365             


Ser Met Ile His Tyr Asn Pro Arg Asp Lys Gln Leu Tyr Ala Trp Asn 
    370                 375                 380                 


Glu Gly Asn Gln Ile Ile Tyr Lys Leu Gln Thr Lys Arg Lys Leu Pro 
385                 390                 395                 400 


Leu Lys 
        


<210>  34
<211>  2786
<212>  DNA
<213>  Homo sapiens

<400>  34
gggggaaggg aacgggggga agccatcttc accccccacc ccaatgcaca cacaattaag     60

ccaggaagca gcttgcaacc actagcctgg ggagggtccg catgtgtcaa gggtgagggc    120

aacagatgct ggacccaggg agctctctgc cacaggtcag tctacaaggc ctcagggacc    180

aacttgccaa cagctggact tgatcactag ctggcaaact gagctcacgt atcgggtgga    240

ataacaagcg gactttgctc tctgctgtgc aaaacgctgt ttttagagga tttgccacag    300

cagcggatag agcaggagag caccaccgga gcccttgaga catccttgag aagagccaca    360

gcataagaga ctgccctgct tggtgttttg caggatgatg gtggcccttc gaggagcttc    420

tgcattgctg gttctgttcc ttgcagcttt tctgcccccg ccgcagtgta cccaggaccc    480

agccatggtg cattacatct accagcgctt tcgagtcttg gagcaagggc tggaaaaatg    540

tacccaagca acgagggcat acattcaaga attccaagag ttctcaaaaa atatatctgt    600

catgctggga agatgtcaga cctacacaag tgagtacaag agtgcagtgg gtaacttggc    660

actgagagtt gaacgtgccc aacgggagat tgactacata caataccttc gagaggctga    720

cgagtgcatc gaatcagagg acaagacact ggcagaaatg ttgctccaag aagctgaaga    780

agagaaaaag atccggactc tgctgaatgc aagctgtgac aacatgctga tgggcataaa    840

gtctttgaaa atagtgaaga agatgatgga cacacatggc tcttggatga aagatgctgt    900

ctataactct ccaaaggtgt acttattaat tggatccaga aacaacactg tttgggaatt    960

tgcaaacata cgggcattca tggaggataa caccaagcca gctccccgga agcaaatcct   1020

aacactttcc tggcagggaa caggccaagt gatctacaaa ggttttctat tttttcataa   1080

ccaagcaact tctaatgaga taatcaaata taacctgcag aagaggactg tggaagatcg   1140

aatgctgctc ccaggagggg taggccgagc attggtttac cagcactccc cctcaactta   1200

cattgacctg gctgtggatg agcatgggct ctgggccatc cactctgggc caggcaccca   1260

tagccatttg gttctcacaa agattgagcc gggcacactg ggagtggagc attcatggga   1320

taccccatgc agaagccagg atgctgaagc ctcattcctc ttgtgtgggg ttctctatgt   1380

ggtctacagt actgggggcc agggccctca tcgcatcacc tgcatctatg atccactggg   1440

cactatcagt gaggaggact tgcccaactt gttcttcccc aagagaccaa gaagtcactc   1500

catgatccat tacaacccca gagataagca gctctatgcc tggaatgaag gaaaccagat   1560

catttacaaa ctccagacaa agagaaagct gcctctgaag taatgcatta cagctgtgag   1620

aaagagcact gtggctttgg cagctgttct acaggacagt gaggctatag ccccttcaca   1680

atatagtatc cctctaatca cacacaggaa gagtgtgtag aagtggaaat acgtatgcct   1740

cctttcccaa atgtcactgc cttaggtatc ttccaagagc ttagatgaga gcatatcatc   1800

aggaaagttt caacaatgtc cattactccc ccaaacctcc tggctctcaa ggatgaccac   1860

attctgatac agcctacttc aagccttttg ttttactgct ccccagcatt tactgtaact   1920

ctgccatctt ccctcccaca attagagttg tatgccagcc cctaatattc accactggct   1980

tttctctccc ctggcctttg ctgaagctct tccctctttt tcaaatgtct attgatattc   2040

tcccattttc actgcccaac taaaatacta ttaatatttc tttcttttct tttctttttt   2100

ttgagacaag gtctcactat gttgcccagg ctggtctcaa actccagagc tcaagagatc   2160

ctcctgcctc agcctcctaa gtacctggga ttacaggcat gtgccaccac acctggctta   2220

aaatactatt tcttattgag gtttaacctc tatttcccct agccctgtcc ttccactaag   2280

cttggtagat gtaataataa agtgaaaata ttaacatttg aatatcgctt tccaggtgtg   2340

gagtgtttgc acatcattta attctcgttt cacctttgtg aaacatgcac aagtctttac   2400

agctgtcatt ctagagttta ggtgagtaac acaattacaa agtgaaagat acagctagaa   2460

aatactacaa atcccatagt ttttccattg cccaaggaag catcaaatac gtatgtttgt   2520

tcacctactc ttatagtcaa tgcgttcatc gtttcagcct aaaaataata gtctgtccct   2580

ttagccagtt ttcatgtctg cacaagacct ttcaataggc ctttcaaatg ataattcctc   2640

cagaaaacca gtctaagggt gaggacccca actctagcct cctcttgtct tgctgtcctc   2700

tgtttctctc tttctgcttt aaattcaata aaagtgacac tgagcaaata acctcatcag   2760

gttatatttg cccacatacc ctaagc                                        2786


<210>  35
<211>  1328
<212>  PRT
<213>  Homo sapiens

<400>  35

Met Ser Ser Gly Asp Pro Ala His Leu Gly Leu Cys Leu Trp Leu Trp 
1               5                   10                  15      


Leu Gly Ala Thr Leu Gly Arg Glu Gln Val Gln Ala Ser Gly Leu Leu 
            20                  25                  30          


Arg Leu Ala Val Leu Pro Glu Asp Arg Leu Gln Met Lys Trp Arg Glu 
        35                  40                  45              


Ser Glu Gly Ser Gly Leu Gly Tyr Leu Val Gln Val Lys Pro Met Ala 
    50                  55                  60                  


Gly Asp Ser Glu Gln Glu Val Ile Leu Thr Thr Lys Thr Pro Lys Ala 
65                  70                  75                  80  


Thr Val Gly Gly Leu Ser Pro Ser Lys Gly Tyr Thr Leu Gln Ile Phe 
                85                  90                  95      


Glu Leu Thr Gly Ser Gly Arg Phe Leu Leu Ala Arg Arg Glu Phe Val 
            100                 105                 110         


Ile Glu Asp Leu Lys Ser Ser Ser Leu Asp Arg Ser Ser Gln Arg Pro 
        115                 120                 125             


Leu Gly Ser Gly Ala Pro Glu Pro Thr Pro Ser His Thr Gly Ser Pro 
    130                 135                 140                 


Asp Pro Glu Gln Ala Ser Glu Pro Gln Val Ala Phe Thr Pro Ser Gln 
145                 150                 155                 160 


Asp Pro Arg Thr Pro Gly Gly Ser Glu Trp Arg Glu Thr Gly Pro Gln 
                165                 170                 175     


Phe Arg Cys Leu Pro Pro Val Pro Ala Asp Met Val Phe Leu Val Asp 
            180                 185                 190         


Gly Ser Trp Ser Ile Gly His Ser His Phe Gln Gln Val Lys Asp Phe 
        195                 200                 205             


Leu Ala Ser Val Ile Ala Pro Phe Glu Ile Gly Pro Asp Lys Val Gln 
    210                 215                 220                 


Val Gly Leu Thr Gln Tyr Ser Gly Asp Ala Gln Thr Glu Trp Asp Leu 
225                 230                 235                 240 


Asn Ser Leu Ser Thr Lys Glu Gln Val Leu Ala Ala Val Arg Arg Leu 
                245                 250                 255     


Arg Tyr Lys Gly Gly Asn Thr Phe Thr Gly Leu Ala Leu Thr His Val 
            260                 265                 270         


Leu Gly Gln Asn Leu Gln Pro Ala Ala Gly Leu Arg Pro Glu Ala Ala 
        275                 280                 285             


Lys Val Val Ile Leu Val Thr Asp Gly Lys Ser Gln Asp Asp Val His 
    290                 295                 300                 


Thr Ala Ala Arg Val Leu Lys Asp Leu Gly Val Asn Val Phe Ala Val 
305                 310                 315                 320 


Gly Val Lys Asn Ala Asp Glu Ala Glu Leu Arg Leu Leu Ala Ser Pro 
                325                 330                 335     


Pro Arg Asp Ile Thr Val His Ser Val Leu Asp Phe Leu Gln Leu Gly 
            340                 345                 350         


Ala Leu Ala Gly Leu Leu Ser Arg Leu Ile Cys Gln Arg Leu Gln Gly 
        355                 360                 365             


Gly Ser Pro Arg Gln Gly Pro Ala Ala Ala Pro Ala Leu Asp Thr Leu 
    370                 375                 380                 


Pro Ala Pro Thr Ser Leu Val Leu Ser Gln Val Thr Ser Ser Ser Ile 
385                 390                 395                 400 


Arg Leu Ser Trp Thr Pro Ala Pro Arg His Pro Leu Lys Tyr Leu Ile 
                405                 410                 415     


Val Trp Arg Ala Ser Arg Gly Gly Thr Pro Arg Glu Val Val Val Glu 
            420                 425                 430         


Gly Pro Ala Ala Ser Thr Glu Leu His Asn Leu Ala Ser Arg Thr Glu 
        435                 440                 445             


Tyr Leu Val Ser Val Phe Pro Ile Tyr Glu Gly Gly Val Gly Glu Gly 
    450                 455                 460                 


Leu Arg Gly Leu Val Thr Thr Ala Pro Leu Pro Pro Pro Arg Ala Leu 
465                 470                 475                 480 


Thr Leu Ala Ala Val Thr Pro Arg Thr Val His Leu Thr Trp Gln Pro 
                485                 490                 495     


Ser Ala Gly Ala Thr His Tyr Leu Val Arg Cys Ser Pro Ala Ser Pro 
            500                 505                 510         


Lys Gly Glu Glu Glu Glu Arg Glu Val Gln Val Gly Arg Pro Glu Val 
        515                 520                 525             


Leu Leu Asp Gly Leu Glu Pro Gly Arg Asp Tyr Glu Val Ser Val Gln 
    530                 535                 540                 


Ser Leu Arg Gly Pro Glu Gly Ser Glu Ala Arg Gly Ile Arg Ala Arg 
545                 550                 555                 560 


Thr Pro Thr Leu Ala Pro Pro Arg His Leu Gly Phe Ser Asp Val Ser 
                565                 570                 575     


His Asp Ala Ala Arg Val Phe Trp Glu Gly Ala Pro Arg Pro Val Arg 
            580                 585                 590         


Leu Val Arg Val Thr Tyr Val Ser Ser Glu Gly Gly His Ser Gly Gln 
        595                 600                 605             


Thr Glu Ala Pro Gly Asn Ala Thr Ser Ala Thr Leu Gly Pro Leu Ser 
    610                 615                 620                 


Ser Ser Thr Thr Tyr Thr Val Arg Val Thr Cys Leu Tyr Pro Gly Gly 
625                 630                 635                 640 


Gly Ser Ser Thr Leu Thr Gly Arg Val Thr Thr Lys Lys Ala Pro Ser 
                645                 650                 655     


Pro Ser Gln Leu Ser Met Thr Glu Leu Pro Gly Asp Ala Val Gln Leu 
            660                 665                 670         


Ala Trp Val Ala Ala Ala Pro Ser Gly Val Leu Val Tyr Gln Ile Thr 
        675                 680                 685             


Trp Thr Pro Leu Gly Glu Gly Lys Ala His Glu Ile Ser Val Pro Gly 
    690                 695                 700                 


Asn Leu Gly Thr Ala Val Leu Pro Gly Leu Gly Arg His Thr Glu Tyr 
705                 710                 715                 720 


Asp Val Thr Ile Leu Ala Tyr Tyr Arg Asp Gly Ala Arg Ser Asp Pro 
                725                 730                 735     


Val Ser Leu Arg Tyr Thr Pro Ser Thr Val Ser Arg Ser Pro Pro Ser 
            740                 745                 750         


Asn Leu Ala Leu Ala Ser Glu Thr Pro Asp Ser Leu Gln Val Ser Trp 
        755                 760                 765             


Thr Pro Pro Leu Gly Arg Val Leu His Tyr Trp Leu Thr Tyr Ala Pro 
    770                 775                 780                 


Ala Ser Gly Leu Gly Pro Glu Lys Ser Val Ser Val Pro Gly Ala Arg 
785                 790                 795                 800 


Ser His Val Thr Leu Pro Asp Leu Gln Ala Ala Thr Lys Tyr Arg Val 
                805                 810                 815     


Leu Val Ser Ala Ile Tyr Ala Ala Gly Arg Ser Glu Ala Val Ser Ala 
            820                 825                 830         


Thr Gly Gln Thr Ala Cys Pro Ala Leu Arg Pro Asp Gly Ser Leu Pro 
        835                 840                 845             


Gly Phe Asp Leu Met Val Ala Phe Ser Leu Val Glu Lys Ala Tyr Ala 
    850                 855                 860                 


Ser Ile Arg Gly Val Ala Met Glu Pro Ser Ala Phe Gly Gly Thr Pro 
865                 870                 875                 880 


Thr Phe Thr Leu Phe Lys Asp Ala Gln Leu Thr Arg Arg Val Ser Asp 
                885                 890                 895     


Val Tyr Pro Ala Pro Leu Pro Pro Glu His Thr Ile Val Phe Leu Val 
            900                 905                 910         


Arg Leu Leu Pro Glu Thr Pro Arg Glu Ala Phe Ala Leu Trp Gln Met 
        915                 920                 925             


Thr Ala Glu Asp Phe Gln Pro Leu Leu Gly Val Leu Leu Asp Ala Gly 
    930                 935                 940                 


Lys Lys Ser Leu Thr Tyr Phe His Arg Asp Pro Arg Ala Ala Leu Gln 
945                 950                 955                 960 


Glu Ala Thr Phe Asp Pro Gln Glu Val Arg Lys Ile Phe Phe Gly Ser 
                965                 970                 975     


Phe His Lys Val His Val Ala Val Gly Arg Ser Lys Val Arg Leu Tyr 
            980                 985                 990         


Val Asp Cys Arg Lys Val Ala Glu  Arg Pro Leu Gly Glu  Met Gly Ser 
        995                 1000                 1005             


Pro Pro  Ala Ala Gly Phe Val  Thr Leu Gly Arg Leu  Ala Lys Ala 
    1010                 1015                 1020             


Arg Gly  Pro Arg Ser Ser Ser  Ala Ala Phe Gln Leu  Gln Met Leu 
    1025                 1030                 1035             


Gln Ile  Val Cys Ser Asp Thr  Trp Ala Asp Glu Asp  Arg Cys Cys 
    1040                 1045                 1050             


Glu Leu  Pro Ala Ser Arg Asp  Gly Glu Thr Cys Pro  Ala Phe Val 
    1055                 1060                 1065             


Ser Ala  Cys Ser Cys Ser Ser  Glu Thr Pro Gly Pro  Pro Gly Pro 
    1070                 1075                 1080             


Gln Gly  Pro Pro Gly Leu Pro  Gly Arg Asn Gly Thr  Pro Gly Glu 
    1085                 1090                 1095             


Gln Gly  Phe Pro Gly Pro Arg  Gly Glu Pro Gly Pro  Pro Gly Gln 
    1100                 1105                 1110             


Met Gly  Pro Glu Gly Pro Gly  Gly Gln Gln Gly Ser  Pro Gly Thr 
    1115                 1120                 1125             


Gln Gly  Arg Ala Val Gln Gly  Pro Val Gly Pro Pro  Gly Val Lys 
    1130                 1135                 1140             


Gly Glu  Lys Gly Asp His Gly  Leu Pro Gly Leu Gln  Gly His Pro 
    1145                 1150                 1155             


Gly His  Gln Gly Ile Pro Gly  Arg Val Gly Leu Gln  Gly Pro Lys 
    1160                 1165                 1170             


Gly Met  Arg Gly Leu Glu Gly  Thr Ala Gly Leu Pro  Gly Pro Gly 
    1175                 1180                 1185             


Pro Arg  Gly Phe Gln Gly Met  Ala Gly Ala Arg Gly  Thr Ser Gly 
    1190                 1195                 1200             


Glu Arg  Gly Pro Pro Gly Thr  Val Gly Pro Thr Gly  Leu Pro Gly 
    1205                 1210                 1215             


Pro Lys  Gly Glu Arg Gly Glu  Lys Gly Glu Pro Gln  Ser Leu Ala 
    1220                 1225                 1230             


Thr Leu  Tyr Gln Leu Val Ser  Gln Ala Cys Glu Ser  Ala Ile Gln 
    1235                 1240                 1245             


Thr His  Val Ser Lys Phe Asp  Ser Phe His Glu Asn  Thr Arg Pro 
    1250                 1255                 1260             


Pro Met  Pro Ile Leu Glu Gln  Lys Leu Glu Pro Gly  Thr Glu Pro 
    1265                 1270                 1275             


Leu Gly  Ser Pro Gly Thr Arg  Ser Lys Ala Leu Val  Pro Gly Glu 
    1280                 1285                 1290             


Trp Gly  Arg Gly Gly Arg His  Leu Glu Gly Arg Gly  Glu Pro Gly 
    1295                 1300                 1305             


Ala Val  Gly Gln Met Gly Ser  Pro Gly Gln Gln Gly  Ala Ser Thr 
    1310                 1315                 1320             


Gln Gly  Leu Trp Glu 
    1325             


<210>  36
<211>  1278
<212>  PRT
<213>  Homo sapiens

<400>  36

Met Ser Ser Gly Asp Pro Ala His Leu Gly Leu Cys Leu Trp Leu Trp 
1               5                   10                  15      


Leu Gly Ala Thr Leu Gly Arg Glu Gln Val Gln Ala Ser Gly Leu Leu 
            20                  25                  30          


Arg Leu Ala Val Leu Pro Glu Asp Arg Leu Gln Met Lys Trp Arg Glu 
        35                  40                  45              


Ser Glu Gly Ser Gly Leu Gly Tyr Leu Val Gln Val Lys Pro Met Ala 
    50                  55                  60                  


Gly Asp Ser Glu Gln Glu Val Ile Leu Thr Thr Lys Thr Pro Lys Ala 
65                  70                  75                  80  


Thr Val Gly Gly Leu Ser Pro Ser Lys Gly Tyr Thr Leu Gln Ile Phe 
                85                  90                  95      


Glu Leu Thr Gly Ser Gly Arg Phe Leu Leu Ala Arg Arg Glu Phe Val 
            100                 105                 110         


Ile Glu Asp Leu Lys Ser Ser Ser Leu Asp Arg Ser Ser Gln Arg Pro 
        115                 120                 125             


Leu Gly Ser Gly Ala Pro Glu Pro Thr Pro Ser His Thr Gly Ser Pro 
    130                 135                 140                 


Asp Pro Glu Gln Ala Ser Glu Pro Gln Val Ala Phe Thr Pro Ser Gln 
145                 150                 155                 160 


Asp Pro Arg Thr Pro Gly Gly Ser Glu Trp Arg Glu Thr Gly Pro Gln 
                165                 170                 175     


Phe Arg Cys Leu Pro Pro Val Pro Ala Asp Met Val Phe Leu Val Asp 
            180                 185                 190         


Gly Ser Trp Ser Ile Gly His Ser His Phe Gln Gln Val Lys Asp Phe 
        195                 200                 205             


Leu Ala Ser Val Ile Ala Pro Phe Glu Ile Gly Pro Asp Lys Val Gln 
    210                 215                 220                 


Val Gly Leu Thr Gln Tyr Ser Gly Asp Ala Gln Thr Glu Trp Asp Leu 
225                 230                 235                 240 


Asn Ser Leu Ser Thr Lys Glu Gln Val Leu Ala Ala Val Arg Arg Leu 
                245                 250                 255     


Arg Tyr Lys Gly Gly Asn Thr Phe Thr Gly Leu Ala Leu Thr His Val 
            260                 265                 270         


Leu Gly Gln Asn Leu Gln Pro Ala Ala Gly Leu Arg Pro Glu Ala Ala 
        275                 280                 285             


Lys Val Val Ile Leu Val Thr Asp Gly Lys Ser Gln Asp Asp Val His 
    290                 295                 300                 


Thr Ala Ala Arg Val Leu Lys Asp Leu Gly Val Asn Val Phe Ala Val 
305                 310                 315                 320 


Gly Val Lys Asn Ala Asp Glu Ala Glu Leu Arg Leu Leu Ala Ser Pro 
                325                 330                 335     


Pro Arg Asp Ile Thr Val His Ser Val Leu Asp Phe Leu Gln Leu Gly 
            340                 345                 350         


Ala Leu Ala Gly Leu Leu Ser Arg Leu Ile Cys Gln Arg Leu Gln Gly 
        355                 360                 365             


Gly Ser Pro Arg Gln Gly Pro Ala Ala Ala Pro Ala Leu Asp Thr Leu 
    370                 375                 380                 


Pro Ala Pro Thr Ser Leu Val Leu Ser Gln Val Thr Ser Ser Ser Ile 
385                 390                 395                 400 


Arg Leu Ser Trp Thr Pro Ala Pro Arg His Pro Leu Lys Tyr Leu Ile 
                405                 410                 415     


Val Trp Arg Ala Ser Arg Gly Gly Thr Pro Arg Glu Val Val Val Glu 
            420                 425                 430         


Gly Pro Ala Ala Ser Thr Glu Leu His Asn Leu Ala Ser Arg Thr Glu 
        435                 440                 445             


Tyr Leu Val Ser Val Phe Pro Ile Tyr Glu Gly Gly Val Gly Glu Gly 
    450                 455                 460                 


Leu Arg Gly Leu Val Thr Thr Ala Pro Leu Pro Pro Pro Arg Ala Leu 
465                 470                 475                 480 


Thr Leu Ala Ala Val Thr Pro Arg Thr Val His Leu Thr Trp Gln Pro 
                485                 490                 495     


Ser Ala Gly Ala Thr His Tyr Leu Val Arg Cys Ser Pro Ala Ser Pro 
            500                 505                 510         


Lys Gly Glu Glu Glu Glu Arg Glu Val Gln Val Gly Arg Pro Glu Val 
        515                 520                 525             


Leu Leu Asp Gly Leu Glu Pro Gly Arg Asp Tyr Glu Val Ser Val Gln 
    530                 535                 540                 


Ser Leu Arg Gly Pro Glu Gly Ser Glu Ala Arg Gly Ile Arg Ala Arg 
545                 550                 555                 560 


Thr Pro Thr Leu Ala Pro Pro Arg His Leu Gly Phe Ser Asp Val Ser 
                565                 570                 575     


His Asp Ala Ala Arg Val Phe Trp Glu Gly Ala Pro Arg Pro Val Arg 
            580                 585                 590         


Leu Val Arg Val Thr Tyr Val Ser Ser Glu Gly Gly His Ser Gly Gln 
        595                 600                 605             


Thr Glu Ala Pro Gly Asn Ala Thr Ser Ala Thr Leu Gly Pro Leu Ser 
    610                 615                 620                 


Ser Ser Thr Thr Tyr Thr Val Arg Val Thr Cys Leu Tyr Pro Gly Gly 
625                 630                 635                 640 


Gly Ser Ser Thr Leu Thr Gly Arg Val Thr Thr Lys Lys Ala Pro Ser 
                645                 650                 655     


Pro Ser Gln Leu Ser Met Thr Glu Leu Pro Gly Asp Ala Val Gln Leu 
            660                 665                 670         


Ala Trp Val Ala Ala Ala Pro Ser Gly Val Leu Val Tyr Gln Ile Thr 
        675                 680                 685             


Trp Thr Pro Leu Gly Glu Gly Lys Ala His Glu Ile Ser Val Pro Gly 
    690                 695                 700                 


Asn Leu Gly Thr Ala Val Leu Pro Gly Leu Gly Arg His Thr Glu Tyr 
705                 710                 715                 720 


Asp Val Thr Ile Leu Ala Tyr Tyr Arg Asp Gly Ala Arg Ser Asp Pro 
                725                 730                 735     


Val Ser Leu Arg Tyr Thr Pro Ser Thr Val Ser Arg Ser Pro Pro Ser 
            740                 745                 750         


Asn Leu Ala Leu Ala Ser Glu Thr Pro Asp Ser Leu Gln Val Ser Trp 
        755                 760                 765             


Thr Pro Pro Leu Gly Arg Val Leu His Tyr Trp Leu Thr Tyr Ala Pro 
    770                 775                 780                 


Ala Ser Gly Leu Gly Pro Glu Lys Ser Val Ser Val Pro Gly Ala Arg 
785                 790                 795                 800 


Ser His Val Thr Leu Pro Asp Leu Gln Ala Ala Thr Lys Tyr Arg Val 
                805                 810                 815     


Leu Val Ser Ala Ile Tyr Ala Ala Gly Arg Ser Glu Ala Val Ser Ala 
            820                 825                 830         


Thr Gly Gln Thr Ala Cys Pro Ala Leu Arg Pro Asp Gly Ser Leu Pro 
        835                 840                 845             


Gly Phe Asp Leu Met Val Ala Phe Ser Leu Val Glu Lys Ala Tyr Ala 
    850                 855                 860                 


Ser Ile Arg Gly Val Ala Met Glu Pro Ser Ala Phe Gly Gly Thr Pro 
865                 870                 875                 880 


Thr Phe Thr Leu Phe Lys Asp Ala Gln Leu Thr Arg Arg Val Ser Asp 
                885                 890                 895     


Val Tyr Pro Ala Pro Leu Pro Pro Glu His Thr Ile Val Phe Leu Val 
            900                 905                 910         


Arg Leu Leu Pro Glu Thr Pro Arg Glu Ala Phe Ala Leu Trp Gln Met 
        915                 920                 925             


Thr Ala Glu Asp Phe Gln Pro Leu Leu Gly Val Leu Leu Asp Ala Gly 
    930                 935                 940                 


Lys Lys Ser Leu Thr Tyr Phe His Arg Asp Pro Arg Ala Ala Leu Gln 
945                 950                 955                 960 


Glu Ala Thr Phe Asp Pro Gln Glu Val Arg Lys Ile Phe Phe Gly Ser 
                965                 970                 975     


Phe His Lys Val His Val Ala Val Gly Arg Ser Lys Val Arg Leu Tyr 
            980                 985                 990         


Val Asp Cys Arg Lys Val Ala Glu  Arg Pro Leu Gly Glu  Met Gly Ser 
        995                 1000                 1005             


Pro Pro  Ala Ala Gly Phe Val  Thr Leu Gly Arg Leu  Ala Lys Ala 
    1010                 1015                 1020             


Arg Gly  Pro Arg Ser Ser Ser  Ala Ala Phe Gln Leu  Gln Met Leu 
    1025                 1030                 1035             


Gln Ile  Val Cys Ser Asp Thr  Trp Ala Asp Glu Asp  Arg Cys Cys 
    1040                 1045                 1050             


Glu Leu  Pro Ala Ser Arg Asp  Gly Glu Thr Cys Pro  Ala Phe Val 
    1055                 1060                 1065             


Ser Ala  Cys Ser Cys Ser Ser  Glu Thr Pro Gly Pro  Pro Gly Pro 
    1070                 1075                 1080             


Gln Gly  Pro Pro Gly Pro Pro  Gly Val Lys Gly Glu  Lys Gly Asp 
    1085                 1090                 1095             


His Gly  Leu Pro Gly Leu Gln  Gly His Pro Gly His  Gln Gly Ile 
    1100                 1105                 1110             


Pro Gly  Arg Val Gly Leu Gln  Gly Pro Lys Gly Met  Arg Gly Leu 
    1115                 1120                 1125             


Glu Gly  Thr Ala Gly Leu Pro  Gly Pro Gly Pro Arg  Gly Phe Gln 
    1130                 1135                 1140             


Gly Met  Ala Gly Ala Arg Gly  Thr Ser Gly Glu Arg  Gly Pro Pro 
    1145                 1150                 1155             


Gly Thr  Val Gly Pro Thr Gly  Leu Pro Gly Pro Lys  Gly Glu Arg 
    1160                 1165                 1170             


Gly Glu  Lys Gly Glu Pro Gln  Ser Leu Ala Thr Leu  Tyr Gln Leu 
    1175                 1180                 1185             


Val Ser  Gln Ala Cys Glu Ser  Ala Ile Gln Thr His  Val Ser Lys 
    1190                 1195                 1200             


Phe Asp  Ser Phe His Glu Asn  Thr Arg Pro Pro Met  Pro Ile Leu 
    1205                 1210                 1215             


Glu Gln  Lys Leu Glu Pro Gly  Thr Glu Pro Leu Gly  Ser Pro Gly 
    1220                 1225                 1230             


Thr Arg  Ser Lys Ala Leu Val  Pro Gly Glu Trp Gly  Arg Gly Gly 
    1235                 1240                 1245             


Arg His  Leu Glu Gly Arg Gly  Glu Pro Gly Ala Val  Gly Gln Met 
    1250                 1255                 1260             


Gly Ser  Pro Gly Gln Gln Gly  Ala Ser Thr Gln Gly  Leu Trp Glu 
    1265                 1270                 1275             


<210>  37
<211>  1283
<212>  PRT
<213>  Homo sapiens

<400>  37

Met Ser Ser Gly Asp Pro Ala His Leu Gly Leu Cys Leu Trp Leu Trp 
1               5                   10                  15      


Leu Gly Ala Thr Leu Gly Arg Glu Gln Val Gln Ala Ser Gly Leu Leu 
            20                  25                  30          


Arg Leu Ala Val Leu Pro Glu Asp Arg Leu Gln Met Lys Trp Arg Glu 
        35                  40                  45              


Ser Glu Gly Ser Gly Leu Gly Tyr Leu Val Gln Val Lys Pro Met Ala 
    50                  55                  60                  


Gly Asp Ser Glu Gln Glu Val Ile Leu Thr Thr Lys Thr Pro Lys Ala 
65                  70                  75                  80  


Thr Val Gly Gly Leu Ser Pro Ser Lys Gly Tyr Thr Leu Gln Ile Phe 
                85                  90                  95      


Glu Leu Thr Gly Ser Gly Arg Phe Leu Leu Ala Arg Arg Glu Phe Val 
            100                 105                 110         


Ile Glu Asp Leu Lys Ser Ser Ser Leu Asp Arg Ser Ser Gln Arg Pro 
        115                 120                 125             


Leu Gly Ser Gly Ala Pro Glu Pro Thr Pro Ser His Thr Gly Ser Pro 
    130                 135                 140                 


Asp Pro Glu Gln Ala Ser Glu Pro Gln Val Ala Phe Thr Pro Ser Gln 
145                 150                 155                 160 


Asp Pro Arg Thr Pro Ala Gly Pro Gln Phe Arg Cys Leu Pro Pro Val 
                165                 170                 175     


Pro Ala Asp Met Val Phe Leu Val Asp Gly Ser Trp Ser Ile Gly His 
            180                 185                 190         


Ser His Phe Gln Gln Val Lys Asp Phe Leu Ala Ser Val Ile Ala Pro 
        195                 200                 205             


Phe Glu Ile Gly Pro Asp Lys Val Gln Val Gly Leu Thr Gln Tyr Ser 
    210                 215                 220                 


Gly Asp Ala Gln Thr Glu Trp Asp Leu Asn Ser Leu Ser Thr Lys Glu 
225                 230                 235                 240 


Gln Val Leu Ala Ala Val Arg Arg Leu Arg Tyr Lys Gly Gly Asn Thr 
                245                 250                 255     


Phe Thr Gly Leu Ala Leu Thr His Val Leu Gly Gln Asn Leu Gln Pro 
            260                 265                 270         


Ala Ala Gly Leu Arg Pro Glu Ala Ala Lys Val Val Ile Leu Val Thr 
        275                 280                 285             


Asp Gly Lys Ser Gln Asp Asp Val His Thr Ala Ala Arg Val Leu Lys 
    290                 295                 300                 


Asp Leu Gly Val Asn Val Phe Ala Val Gly Val Lys Asn Ala Asp Glu 
305                 310                 315                 320 


Ala Glu Leu Arg Leu Leu Ala Ser Pro Pro Arg Asp Ile Thr Val His 
                325                 330                 335     


Ser Val Leu Asp Phe Leu Gln Leu Gly Ala Leu Ala Gly Leu Leu Ser 
            340                 345                 350         


Arg Leu Ile Cys Gln Arg Leu Gln Gly Gly Ser Pro Arg Gln Gly Pro 
        355                 360                 365             


Ala Ala Ala Pro Ala Leu Asp Thr Leu Pro Ala Pro Thr Ser Leu Val 
    370                 375                 380                 


Leu Ser Gln Val Thr Ser Ser Ser Ile Arg Leu Ser Trp Thr Pro Ala 
385                 390                 395                 400 


Pro Arg His Pro Leu Lys Tyr Leu Ile Val Trp Arg Ala Ser Arg Gly 
                405                 410                 415     


Gly Thr Pro Arg Glu Val Val Val Glu Gly Pro Ala Ala Ser Thr Glu 
            420                 425                 430         


Leu His Asn Leu Ala Ser Arg Thr Glu Tyr Leu Val Ser Val Phe Pro 
        435                 440                 445             


Ile Tyr Glu Gly Gly Val Gly Glu Gly Leu Arg Gly Leu Val Thr Thr 
    450                 455                 460                 


Ala Pro Leu Pro Pro Pro Arg Ala Leu Thr Leu Ala Ala Val Thr Pro 
465                 470                 475                 480 


Arg Thr Val His Leu Thr Trp Gln Pro Ser Ala Gly Ala Thr His Tyr 
                485                 490                 495     


Leu Val Arg Cys Ser Pro Ala Ser Pro Lys Gly Glu Glu Glu Glu Arg 
            500                 505                 510         


Glu Val Gln Val Gly Arg Pro Glu Val Leu Leu Asp Gly Leu Glu Pro 
        515                 520                 525             


Gly Arg Asp Tyr Glu Val Ser Val Gln Ser Leu Arg Gly Pro Glu Gly 
    530                 535                 540                 


Ser Glu Ala Arg Gly Ile Arg Ala Arg Thr Pro Thr Leu Ala Pro Pro 
545                 550                 555                 560 


Arg His Leu Gly Phe Ser Asp Val Ser His Asp Ala Ala Arg Val Phe 
                565                 570                 575     


Trp Glu Gly Ala Pro Arg Pro Val Arg Leu Val Arg Val Thr Tyr Val 
            580                 585                 590         


Ser Ser Glu Gly Gly His Ser Gly Gln Thr Glu Ala Pro Gly Asn Ala 
        595                 600                 605             


Thr Ser Ala Thr Leu Gly Pro Leu Ser Ser Ser Thr Thr Tyr Thr Val 
    610                 615                 620                 


Arg Val Thr Cys Leu Tyr Pro Gly Gly Gly Ser Ser Thr Leu Thr Gly 
625                 630                 635                 640 


Arg Val Thr Thr Lys Lys Ala Pro Ser Pro Ser Gln Leu Ser Met Thr 
                645                 650                 655     


Glu Leu Pro Gly Asp Ala Val Gln Leu Ala Trp Val Ala Ala Ala Pro 
            660                 665                 670         


Ser Gly Val Leu Val Tyr Gln Ile Thr Trp Thr Pro Leu Gly Glu Gly 
        675                 680                 685             


Lys Ala His Glu Ile Ser Val Pro Gly Asn Leu Gly Thr Ala Val Leu 
    690                 695                 700                 


Pro Gly Leu Gly Arg His Thr Glu Tyr Asp Val Thr Ile Leu Ala Tyr 
705                 710                 715                 720 


Tyr Arg Asp Gly Ala Arg Ser Asp Pro Val Ser Leu Arg Tyr Thr Pro 
                725                 730                 735     


Ser Thr Val Ser Arg Ser Pro Pro Ser Asn Leu Ala Leu Ala Ser Glu 
            740                 745                 750         


Thr Pro Asp Ser Leu Gln Val Ser Trp Thr Pro Pro Leu Gly Arg Val 
        755                 760                 765             


Leu His Tyr Trp Leu Thr Tyr Ala Pro Ala Ser Gly Leu Gly Pro Glu 
    770                 775                 780                 


Lys Ser Val Ser Val Pro Gly Ala Arg Ser His Val Thr Leu Pro Asp 
785                 790                 795                 800 


Leu Gln Ala Ala Thr Lys Tyr Arg Val Leu Val Ser Ala Ile Tyr Ala 
                805                 810                 815     


Ala Gly Arg Ser Glu Ala Val Ser Ala Thr Gly Gln Thr Ala Cys Pro 
            820                 825                 830         


Ala Leu Arg Pro Asp Gly Ser Leu Pro Gly Phe Asp Leu Met Val Ala 
        835                 840                 845             


Phe Ser Leu Val Glu Lys Ala Tyr Ala Ser Ile Arg Gly Val Ala Met 
    850                 855                 860                 


Glu Pro Ser Ala Phe Gly Gly Thr Pro Thr Phe Thr Leu Phe Lys Asp 
865                 870                 875                 880 


Ala Gln Leu Thr Arg Arg Val Ser Asp Val Tyr Pro Ala Pro Leu Pro 
                885                 890                 895     


Pro Glu His Thr Ile Val Phe Leu Val Arg Leu Leu Pro Glu Thr Pro 
            900                 905                 910         


Arg Glu Ala Phe Ala Leu Trp Gln Met Thr Ala Glu Asp Phe Gln Pro 
        915                 920                 925             


Leu Leu Gly Val Leu Leu Asp Ala Gly Lys Lys Ser Leu Thr Tyr Phe 
    930                 935                 940                 


His Arg Asp Pro Arg Ala Ala Leu Gln Glu Ala Thr Phe Asp Pro Gln 
945                 950                 955                 960 


Glu Val Arg Lys Ile Phe Phe Gly Ser Phe His Lys Val His Val Ala 
                965                 970                 975     


Val Gly Arg Ser Lys Val Arg Leu Tyr Val Asp Cys Arg Lys Val Ala 
            980                 985                 990         


Glu Arg Pro Leu Gly Glu Met Gly  Ser Pro Pro Ala Ala  Gly Phe Val 
        995                 1000                 1005             


Thr Leu  Gly Arg Leu Ala Lys  Ala Arg Gly Pro Arg  Ser Ser Ser 
    1010                 1015                 1020             


Ala Ala  Phe Gln Leu Gln Met  Leu Gln Ile Val Cys  Ser Asp Thr 
    1025                 1030                 1035             


Trp Ala  Asp Glu Asp Arg Cys  Cys Glu Leu Pro Ala  Ser Arg Asp 
    1040                 1045                 1050             


Gly Glu  Thr Cys Pro Ala Phe  Val Ser Ala Cys Ser  Cys Ser Ser 
    1055                 1060                 1065             


Glu Thr  Pro Gly Pro Pro Gly  Pro Gln Gly Pro Pro  Gly Leu Pro 
    1070                 1075                 1080             


Gly Arg  Asn Gly Thr Pro Gly  Glu Gln Gly Phe Pro  Gly Pro Arg 
    1085                 1090                 1095             


Gly Pro  Pro Gly Val Lys Gly  Glu Lys Gly Asp His  Gly Leu Pro 
    1100                 1105                 1110             


Gly Leu  Gln Gly His Pro Gly  His Gln Gly Ile Pro  Gly Arg Val 
    1115                 1120                 1125             


Gly Leu  Gln Gly Pro Lys Gly  Met Arg Gly Leu Glu  Gly Thr Ala 
    1130                 1135                 1140             


Gly Leu  Pro Gly Pro Gly Pro  Arg Gly Phe Gln Gly  Met Ala Gly 
    1145                 1150                 1155             


Ala Arg  Gly Thr Ser Gly Glu  Arg Gly Pro Pro Gly  Thr Val Gly 
    1160                 1165                 1170             


Pro Thr  Gly Leu Pro Gly Pro  Lys Gly Glu Arg Gly  Glu Lys Gly 
    1175                 1180                 1185             


Glu Pro  Gln Ser Leu Ala Thr  Leu Tyr Gln Leu Val  Ser Gln Ala 
    1190                 1195                 1200             


Ser His  Val Ser Lys Phe Asp  Ser Phe His Glu Asn  Thr Arg Pro 
    1205                 1210                 1215             


Pro Met  Pro Ile Leu Glu Gln  Lys Leu Glu Pro Gly  Thr Glu Pro 
    1220                 1225                 1230             


Leu Gly  Ser Pro Gly Thr Arg  Ser Lys Ala Leu Val  Pro Gly Glu 
    1235                 1240                 1245             


Trp Gly  Arg Gly Gly Arg His  Leu Glu Gly Arg Gly  Glu Pro Gly 
    1250                 1255                 1260             


Ala Val  Gly Gln Met Gly Ser  Pro Gly Gln Gln Gly  Ala Ser Thr 
    1265                 1270                 1275             


Gln Gly  Leu Trp Glu 
    1280             


<210>  38
<211>  3987
<212>  DNA
<213>  Homo sapiens

<400>  38
atgagctccg gagaccctgc acacctcggc ctctgcctct ggctgtggct gggcgccacc     60

ctgggaagag agcaagttca agcaagcggt ctcctgaggc tggctgtgct gcctgaggac    120

cggctgcaga tgaagtggag agagtcggag gggagcggcc tcggctacct ggtgcaggtg    180

aagcccatgg caggggactc ggaacaggag gtgatactga ccaccaagac ccctaaggcc    240

acagtggggg gcctgagccc ctccaagggc tacaccttgc agatcttcga gctcactggc    300

tctgggcgct tcctgctagc tcggagggag tttgtgattg aggatctgaa gagtagctcc    360

ctggacagga gcagccagag gcccctcggc tctggagccc cggagcccac cccctcccac    420

acggggagcc cagaccctga gcaggcttct gagccccaag ttgccttcac accaagccag    480

gatccgcgca ctcctggtgg gtcagagtgg agagagaccg gcccccagtt ccgctgcctg    540

ccccccgtgc ctgctgacat ggtcttcctg gtggacgggt cctggagcat tggccacagt    600

cacttccagc aggtcaagga cttcctggcc agtgtcatcg caccctttga aatcgggccg    660

gataaggtcc aagtaggcct gactcagtac agcggggatg ctcagactga gtgggacctg    720

aactccctca gcaccaagga acaggtgctg gcagctgtgc gccgcctccg ctacaagggg    780

gggaacacgt tcacaggcct tgccctgacc cacgtgctgg ggcagaacct gcagccggcg    840

gctggcctcc gtccagaggc agccaaggtg gtgattctgg tgacggacgg caagtcccag    900

gacgatgtgc acactgctgc ccgtgtcctc aaggacctgg gcgtgaacgt cttcgctgtg    960

ggtgtgaaga acgccgatga ggctgagctg aggctcctgg cgtccccgcc gagggacatc   1020

accgtccaca gcgtgctgga cttcctgcag ctcggcgcgc tggctggcct gctcagccgt   1080

ctcatctgcc agaggctcca gggtgggagc ccgcggcagg gcccagcagc ggctccagcc   1140

ctggacaccc tccctgcccc caccagcctg gtcctgagcc aggtgacctc ctccagcatc   1200

cgcctgtcct ggactccagc cccccggcac cccctcaagt atctgatcgt ttggcgagcc   1260

tctagaggtg gcacccccag ggaggtggtg gtggagggac ccgccgcctc cacggagctg   1320

cacaacctgg cctcccgcac agagtacctg gtctccgtgt tccccatcta tgagggcggg   1380

gttggcgaag gcctgcgggg cctggtgacc acagcacctc tgcctccgcc ccgggcgctg   1440

accctggccg cagtgacgcc cagaaccgtc cacctcacct ggcagccctc ggccggggcc   1500

acccactacc tggtgcgatg ttctcctgct tcccccaagg gtgaagagga ggagcgagag   1560

gtgcaggtcg ggcggcccga ggtgctgctg gatggcctgg aacctggcag ggactatgag   1620

gtctcggtgc agagcctgcg aggccctgag ggcagcgagg cccggggcat ccgtgccagg   1680

acccccaccc tggccccccc gagacacctg ggcttctcag acgtgagcca cgacgcggca   1740

cgagtgttct gggagggtgc cccgaggcct gtgcgcctgg tcagggtcac ctatgtgtcc   1800

agcgagggtg gacactcggg gcagacagag gctcctggga acgccacctc ggccacgctg   1860

gggcctctct cttcctccac cacctacact gtccgtgtca cctgcctcta ccctgggggt   1920

ggctcctcta cgctgactgg ccgggtgacc accaagaaag ctcccagccc aagccagctg   1980

tccatgacgg agctgccagg ggatgcagtc cagctggcgt gggtggccgc agccccgtct   2040

ggcgtgcttg tctaccagat cacgtggacg cccctgggag aggggaaggc tcacgagatc   2100

tctgtcccag ggaacctcgg cacggccgtc ctgcctggcc tagggaggca cacagagtac   2160

gacgtcacca tcttggccta ctacagggac ggggcccgca gtgaccctgt gtccctccgc   2220

tataccccct ccacggtgag caggagccca ccctccaacc tggccctggc ctcggagacc   2280

cccgacagcc tgcaggtcag ctggacgccc ccgcttggcc gcgtgctcca ttactggctc   2340

acctacgccc ccgcctctgg cttgggaccc gagaaatccg tctctgtgcc aggagccagg   2400

agccacgtga cactgcccga cctgcaggca gccacgaagt acagggtcct ggtctcagct   2460

atctatgcag caggcaggag tgaggctgtg tctgccacgg gccagacagc ctgcccagcc   2520

ctccgccctg acggctccct cccagggttt gacctgatgg tggccttcag cctggtggaa   2580

aaggcttatg cgtccatccg gggcgtggcc atggagccct ctgccttcgg tgggaccccg   2640

accttcacgc tcttcaagga cgcccagctg acaagacggg tcagtgacgt ctacccagcc   2700

cccctacctc cagagcacac catcgtcttc cttgtgcgcc tacttcccga gacaccccgt   2760

gaggccttcg cgctgtggca gatgacagcc gaggacttcc agcccctcct tggggttctg   2820

ctggatgccg ggaagaagtc cctgacctac ttccaccgtg accccagggc tgccttgcag   2880

gaggccacct tcgacccgca ggaagtgagg aagattttct tcgggagctt ccacaaggtg   2940

cacgtggctg tgggccgctc caaggtcagg ctctatgtgg actgccggaa ggtggctgag   3000

cggccccttg gggagatggg cagcccaccc gctgcgggct tcgtcacgct ggggaggctg   3060

gccaaggcca ggggcccccg gagcagttcg gccgcgtttc agctccagat gctgcagatc   3120

gtgtgcagtg acacctgggc cgatgaggac cggtgctgtg agctccctgc ctcgagggat   3180

ggagagacct gccccgcctt cgtgtctgcc tgttcctgtt cctcagagac ccctgggccc   3240

ccaggacctc aaggaccccc aggcctccct gggaggaatg gcaccccagg agagcagggc   3300

ttcccagggc ccaggggaga gcccgggcca cccggacaga tgggaccaga aggtcctgga   3360

ggccagcagg gctcgccggg gacccagggc cgtgcagtcc aggggcctgt gggtccacca   3420

ggggtcaaag gagagaaggg agaccatggg cttccaggct tgcagggcca ccccggccac   3480

cagggcatcc ccgggagagt tggcctccag ggaccaaagg gaatgagagg cctggaggga   3540

actgctggcc tgcctggacc cggccccagg gggttccagg gcatggcagg ggccaggggc   3600

actagtggag agcgaggacc tccagggacc gtggggccca caggactgcc agggcccaaa   3660

ggggaacgag gagagaaggg cgagccgcag tcccttgcca ccctctacca gcttgtgagc   3720

caggcctgtg agtctgccat tcagacacac gtgtcaaagt tcgactcctt ccacgagaac   3780

accaggcccc ccatgcccat cttggagcag aagctggagc cgggcactga gcccctgggg   3840

tcccctggca cccgcagcaa ggccctggtt cctggagaat gggggcgtgg tggccgccac   3900

cttgagggca gaggggagcc tggagctgtt ggtcagatgg gcagccctgg gcagcagggg   3960

gctagcaccc agggcctctg ggagtga                                       3987


<210>  39
<211>  3837
<212>  DNA
<213>  Homo sapiens

<400>  39
atgagctccg gagaccctgc acacctcggc ctctgcctct ggctgtggct gggcgccacc     60

ctgggaagag agcaagttca agcaagcggt ctcctgaggc tggctgtgct gcctgaggac    120

cggctgcaga tgaagtggag agagtcggag gggagcggcc tcggctacct ggtgcaggtg    180

aagcccatgg caggggactc ggaacaggag gtgatactga ccaccaagac ccctaaggcc    240

acagtggggg gcctgagccc ctccaagggc tacaccttgc agatcttcga gctcactggc    300

tctgggcgct tcctgctagc tcggagggag tttgtgattg aggatctgaa gagtagctcc    360

ctggacagga gcagccagag gcccctcggc tctggagccc cggagcccac cccctcccac    420

acggggagcc cagaccctga gcaggcttct gagccccaag ttgccttcac accaagccag    480

gatccgcgca ctcctggtgg gtcagagtgg agagagaccg gcccccagtt ccgctgcctg    540

ccccccgtgc ctgctgacat ggtcttcctg gtggacgggt cctggagcat tggccacagt    600

cacttccagc aggtcaagga cttcctggcc agtgtcatcg caccctttga aatcgggccg    660

gataaggtcc aagtaggcct gactcagtac agcggggatg ctcagactga gtgggacctg    720

aactccctca gcaccaagga acaggtgctg gcagctgtgc gccgcctccg ctacaagggg    780

gggaacacgt tcacaggcct tgccctgacc cacgtgctgg ggcagaacct gcagccggcg    840

gctggcctcc gtccagaggc agccaaggtg gtgattctgg tgacggacgg caagtcccag    900

gacgatgtgc acactgctgc ccgtgtcctc aaggacctgg gcgtgaacgt cttcgctgtg    960

ggtgtgaaga acgccgatga ggctgagctg aggctcctgg cgtccccgcc gagggacatc   1020

accgtccaca gcgtgctgga cttcctgcag ctcggcgcgc tggctggcct gctcagccgt   1080

ctcatctgcc agaggctcca gggtgggagc ccgcggcagg gcccagcagc ggctccagcc   1140

ctggacaccc tccctgcccc caccagcctg gtcctgagcc aggtgacctc ctccagcatc   1200

cgcctgtcct ggactccagc cccccggcac cccctcaagt atctgatcgt ttggcgagcc   1260

tctagaggtg gcacccccag ggaggtggtg gtggagggac ccgccgcctc cacggagctg   1320

cacaacctgg cctcccgcac agagtacctg gtctccgtgt tccccatcta tgagggcggg   1380

gttggcgaag gcctgcgggg cctggtgacc acagcacctc tgcctccgcc ccgggcgctg   1440

accctggccg cagtgacgcc cagaaccgtc cacctcacct ggcagccctc ggccggggcc   1500

acccactacc tggtgcgatg ttctcctgct tcccccaagg gtgaagagga ggagcgagag   1560

gtgcaggtcg ggcggcccga ggtgctgctg gatggcctgg aacctggcag ggactatgag   1620

gtctcggtgc agagcctgcg aggccctgag ggcagcgagg cccggggcat ccgtgccagg   1680

acccccaccc tggccccccc gagacacctg ggcttctcag acgtgagcca cgacgcggca   1740

cgagtgttct gggagggtgc cccgaggcct gtgcgcctgg tcagggtcac ctatgtgtcc   1800

agcgagggtg gacactcggg gcagacagag gctcctggga acgccacctc ggccacgctg   1860

gggcctctct cttcctccac cacctacact gtccgtgtca cctgcctcta ccctgggggt   1920

ggctcctcta cgctgactgg ccgggtgacc accaagaaag ctcccagccc aagccagctg   1980

tccatgacgg agctgccagg ggatgcagtc cagctggcgt gggtggccgc agccccgtct   2040

ggcgtgcttg tctaccagat cacgtggacg cccctgggag aggggaaggc tcacgagatc   2100

tctgtcccag ggaacctcgg cacggccgtc ctgcctggcc tagggaggca cacagagtac   2160

gacgtcacca tcttggccta ctacagggac ggggcccgca gtgaccctgt gtccctccgc   2220

tataccccct ccacggtgag caggagccca ccctccaacc tggccctggc ctcggagacc   2280

cccgacagcc tgcaggtcag ctggacgccc ccgcttggcc gcgtgctcca ttactggctc   2340

acctacgccc ccgcctctgg cttgggaccc gagaaatccg tctctgtgcc aggagccagg   2400

agccacgtga cactgcccga cctgcaggca gccacgaagt acagggtcct ggtctcagct   2460

atctatgcag caggcaggag tgaggctgtg tctgccacgg gccagacagc ctgcccagcc   2520

ctccgccctg acggctccct cccagggttt gacctgatgg tggccttcag cctggtggaa   2580

aaggcttatg cgtccatccg gggcgtggcc atggagccct ctgccttcgg tgggaccccg   2640

accttcacgc tcttcaagga cgcccagctg acaagacggg tcagtgacgt ctacccagcc   2700

cccctacctc cagagcacac catcgtcttc cttgtgcgcc tacttcccga gacaccccgt   2760

gaggccttcg cgctgtggca gatgacagcc gaggacttcc agcccctcct tggggttctg   2820

ctggatgccg ggaagaagtc cctgacctac ttccaccgtg accccagggc tgccttgcag   2880

gaggccacct tcgacccgca ggaagtgagg aagattttct tcgggagctt ccacaaggtg   2940

cacgtggctg tgggccgctc caaggtcagg ctctatgtgg actgccggaa ggtggctgag   3000

cggccccttg gggagatggg cagcccaccc gctgcgggct tcgtcacgct ggggaggctg   3060

gccaaggcca ggggcccccg gagcagttcg gccgcgtttc agctccagat gctgcagatc   3120

gtgtgcagtg acacctgggc cgatgaggac cggtgctgtg agctccctgc ctcgagggat   3180

ggagagacct gccccgcctt cgtgtctgcc tgttcctgtt cctcagagac ccctgggccc   3240

ccaggacctc aaggaccccc aggtccacca ggggtcaaag gagagaaggg agaccatggg   3300

cttccaggct tgcagggcca ccccggccac cagggcatcc ccgggagagt tggcctccag   3360

ggaccaaagg gaatgagagg cctggaggga actgctggcc tgcctggacc tggccccagg   3420

gggttccagg gcatggcagg ggccaggggc actagtggag agcgaggacc tccagggacc   3480

gtggggccca caggactgcc agggcccaaa ggggaacgag gagagaaggg cgagccgcag   3540

tcccttgcca ccctctacca gcttgtgagc caggcctgtg agtctgccat tcagacacac   3600

gtgtcaaagt tcgactcctt ccacgagaac accaggcccc ccatgcccat cttggagcag   3660

aagctggagc cgggcactga gcccctgggg tcccctggca cccgcagcaa ggccctggtt   3720

cctggagaat gggggcgtgg tggccgccac cttgagggca gaggggagcc tggagctgtt   3780

ggtcagatgg gcagccctgg gcagcagggg gctagcaccc agggcctctg ggagtga      3837


<210>  40
<211>  4168
<212>  DNA
<213>  Homo sapiens

<400>  40
ataagctcca gccttcctgt ggccacagca ggaccagagt ggaccagcac accccaggag     60

agaggactgg ggtcccagga gtaggaggag cccgagcacc atgagctccg gagaccctgc    120

acacctcggc ctctgcctct ggctgtggct gggcgccacc ctgggaagag agcaagttca    180

agcaagcggt ctcctgaggc tggctgtgct gcctgaggac cggctgcaga tgaagtggag    240

agagtcggag gggagcggcc tcggctacct ggtgcaggtg aagcccatgg caggggactc    300

ggaacaggag gtgatactga ccaccaagac ccctaaggcc acagtggggg gcctgagccc    360

ctccaagggc tacaccttgc agatcttcga gctcactggc tctgggcgct tcctgctagc    420

tcggagggag tttgtgattg aggatctgaa gagtagctcc ctggacagga gcagccagag    480

gcccctcggc tctggagccc cggagcccac cccctcccac acggggagcc cagaccctga    540

gcaggcttct gagccccaag ttgccttcac accaagccag gatccgcgca ctcctgccgg    600

cccccagttc cgctgcctgc cccccgtgcc tgctgacatg gtcttcctgg tggacgggtc    660

ctggagcatt ggccacagtc acttccagca ggtcaaggac ttcctggcca gtgtcatcgc    720

accctttgaa atcgggccgg ataaggtcca agtaggcctg actcagtaca gcggggatgc    780

tcagactgag tgggacctga actccctcag caccaaggaa caggtgctgg cagctgtgcg    840

ccgcctccgc tacaaggggg ggaacacgtt cacaggcctt gccctgaccc acgtgctggg    900

gcagaacctg cagccggcgg ctggcctccg tccagaggca gccaaggtgg tgattctggt    960

gacggacggc aagtcccagg acgatgtgca cactgctgcc cgtgtcctca aggacctggg   1020

cgtgaacgtc ttcgctgtgg gtgtgaagaa cgccgatgag gctgagctga ggctcctggc   1080

gtccccgccg agggacatca ccgtccacag cgtgctggac ttcctgcagc tcggcgcgct   1140

ggctggcctg ctcagccgtc tcatctgcca gaggctccag ggtgggagcc cgcggcaggg   1200

cccagcagcg gctccagccc tggacaccct ccctgccccc accagcctgg tcctgagcca   1260

ggtgacctcc tccagcatcc gcctgtcctg gactccagcc ccccggcacc ccctcaagta   1320

tctgatcgtt tggcgagcct ctagaggtgg cacccccagg gaggtggtgg tggagggacc   1380

cgccgcctcc acggagctgc acaacctggc ctcccgcaca gagtacctgg tctccgtgtt   1440

ccccatctat gagggcgggg ttggcgaagg cctgcggggc ctggtgacca cagcacctct   1500

gcctccgccc cgggcgctga ccctggccgc agtgacgccc agaaccgtcc acctcacctg   1560

gcagccctcg gccggggcca cccactacct ggtgcgatgt tctcctgctt cccccaaggg   1620

tgaagaggag gagcgagagg tgcaggtcgg gcggcccgag gtgctgctgg atggcctgga   1680

acctggcagg gactatgagg tctcggtgca gagcctgcga ggccctgagg gcagcgaggc   1740

ccggggcatc cgtgccagga cccccaccct ggcccccccg agacacctgg gcttctcaga   1800

cgtgagccac gacgcggcac gagtgttctg ggagggtgcc ccgaggcctg tgcgcctggt   1860

cagggtcacc tatgtgtcca gcgagggtgg acactcgggg cagacagagg ctcctgggaa   1920

cgccacctcg gccacgctgg ggcctctctc ttcctccacc acctacactg tccgtgtcac   1980

ctgcctctac cctgggggtg gctcctctac gctgactggc cgggtgacca ccaagaaagc   2040

tcccagccca agccagctgt ccatgacgga gctgccaggg gatgcagtcc agctggcgtg   2100

ggtggccgca gccccgtctg gcgtgcttgt ctaccagatc acgtggacgc ccctgggaga   2160

ggggaaggct cacgagatct ctgtcccagg gaacctcggc acggccgtcc tgcctggcct   2220

agggaggcac acagagtacg acgtcaccat cttggcctac tacagggacg gggcccgcag   2280

tgaccctgtg tccctccgct ataccccctc cacggtgagc aggagcccac cctccaacct   2340

ggccctggcc tcggagaccc ccgacagcct gcaggtcagc tggacgcccc cgcttggccg   2400

cgtgctccat tactggctca cctacgcccc cgcctctggc ttgggacccg agaaatccgt   2460

ctctgtgcca ggagccagga gccacgtgac actgcccgac ctgcaggcag ccacgaagta   2520

cagggtcctg gtctcagcta tctatgcagc aggcaggagt gaggctgtgt ctgccacggg   2580

ccagacagcc tgcccagccc tccgccctga cggctccctc ccagggtttg acctgatggt   2640

ggccttcagc ctggtggaaa aggcttatgc gtccatccgg ggcgtggcca tggagccctc   2700

tgccttcggt gggaccccga ccttcacgct cttcaaggac gcccagctga caagacgggt   2760

cagtgacgtc tacccagccc ccctacctcc agagcacacc atcgtcttcc ttgtgcgcct   2820

acttcccgag acaccccgtg aggccttcgc gctgtggcag atgacagccg aggacttcca   2880

gcccctcctt ggggttctgc tggatgccgg gaagaagtcc ctgacctact tccaccgtga   2940

ccccagggct gccttgcagg aggccacctt cgacccgcag gaagtgagga agattttctt   3000

cgggagcttc cacaaggtgc acgtggctgt gggccgctcc aaggtcaggc tctatgtgga   3060

ctgccggaag gtggctgagc ggccccttgg ggagatgggc agcccacccg ctgcgggctt   3120

cgtcacgctg gggaggctgg ccaaggccag gggcccccgg agcagttcgg ccgcgtttca   3180

gctccagatg ctgcagatcg tgtgcagtga cacctgggcc gatgaggacc ggtgctgtga   3240

gctccctgcc tcgagggatg gagagacctg ccccgccttc gtgtctgcct gttcctgttc   3300

ctcagagacc cctgggcccc caggacctca aggaccccca ggcctccctg ggaggaatgg   3360

caccccagga gagcagggct tcccagggcc caggggtcca ccaggggtca aaggagagaa   3420

gggagaccat gggcttccag gcttgcaggg ccaccccggc caccagggca tccccgggag   3480

agttggcctc cagggaccaa agggaatgag aggcctggag ggaactgctg gcctgcctgg   3540

acctggcccc agggggttcc agggcatggc aggggccagg ggcactagtg gagagcgagg   3600

acctccaggg accgtggggc ccacaggact gccagggccc aaaggggaac gaggagagaa   3660

gggcgagccg cagtcccttg ccaccctcta ccagcttgtg agccaggcct cacacgtgtc   3720

aaagttcgac tccttccacg agaacaccag gccccccatg cccatcttgg agcagaagct   3780

ggagccgggc actgagcccc tggggtcccc tggcacccgc agcaaggccc tggttcctgg   3840

agaatggggg cgtggtggcc gccaccttga gggcagaggg gagcctggag ctgttggtca   3900

gatgggcagc cctgggcagc agggggctag cacccagggc ctctgggagt gacaggacat   3960

tttctgcact gccccgagga acgctgagcc ttcctccctg ggtttgtctg gacaccgaga   4020

gcgaccacat cctggagaag ccaggagaaa agctcaggaa gagcctgcag gtggaaggag   4080

agggaagcag cggcctcggc caaggcccac cccatactct tggctctgta gcatttccaa   4140

gttcagataa acccctgagt gctcaccc                                      4168


<210>  41
<211>  2778
<212>  PRT
<213>  Homo sapiens

<400>  41

Met Ala Leu Gly Lys Val Leu Ala Met Ala Leu Val Leu Ala Leu Ala 
1               5                   10                  15      


Val Leu Gly Ser Leu Ser Pro Gly Ala Arg Ala Gly Asp Cys Lys Gly 
            20                  25                  30          


Gln Arg Gln Val Leu Arg Glu Ala Pro Gly Phe Val Thr Asp Gly Ala 
        35                  40                  45              


Gly Asn Tyr Ser Val Asn Gly Asn Cys Glu Trp Leu Ile Glu Ala Pro 
    50                  55                  60                  


Ser Pro Gln His Arg Ile Leu Leu Asp Phe Leu Phe Leu Asp Thr Glu 
65                  70                  75                  80  


Cys Thr Tyr Asp Tyr Leu Phe Val Tyr Asp Gly Asp Ser Pro Arg Gly 
                85                  90                  95      


Pro Leu Leu Ala Ser Leu Ser Gly Ser Thr Arg Pro Pro Pro Ile Glu 
            100                 105                 110         


Ala Ser Ser Gly Lys Met Leu Leu His Leu Phe Ser Asp Ala Asn Tyr 
        115                 120                 125             


Asn Leu Leu Gly Phe Asn Ala Ser Phe Arg Phe Ser Leu Cys Pro Gly 
    130                 135                 140                 


Gly Cys Gln Ser His Gly Gln Cys Gln Pro Pro Gly Val Cys Ala Cys 
145                 150                 155                 160 


Glu Pro Gly Trp Gly Gly Pro Asp Cys Gly Leu Gln Glu Cys Ser Ala 
                165                 170                 175     


Tyr Cys Gly Ser His Gly Thr Cys Ala Ser Pro Leu Gly Pro Cys Arg 
            180                 185                 190         


Cys Glu Pro Gly Phe Leu Gly Arg Ala Cys Asp Leu His Leu Trp Glu 
        195                 200                 205             


Asn Gln Gly Ala Gly Trp Trp His Asn Val Ser Ala Arg Asp Pro Ala 
    210                 215                 220                 


Phe Ser Ala Arg Ile Gly Ala Ala Gly Ala Phe Leu Ser Pro Pro Gly 
225                 230                 235                 240 


Leu Leu Ala Val Phe Gly Gly Gln Asp Leu Asn Asn Ala Leu Gly Asp 
                245                 250                 255     


Leu Val Leu Tyr Asn Phe Ser Ala Asn Thr Trp Glu Ser Trp Asp Leu 
            260                 265                 270         


Ser Pro Ala Pro Ala Ala Arg His Ser His Val Ala Val Ala Trp Ala 
        275                 280                 285             


Gly Ser Leu Val Leu Met Gly Gly Glu Leu Ala Asp Gly Ser Leu Thr 
    290                 295                 300                 


Asn Asp Val Trp Ala Phe Ser Pro Leu Gly Arg Gly His Trp Glu Leu 
305                 310                 315                 320 


Leu Ala Pro Pro Ala Ser Ser Ser Ser Gly Pro Pro Gly Leu Ala Gly 
                325                 330                 335     


His Ala Ala Ala Leu Val Asp Asp Val Trp Leu Tyr Val Ser Gly Gly 
            340                 345                 350         


Arg Thr Pro His Asp Leu Phe Ser Ser Gly Leu Phe Arg Phe Arg Leu 
        355                 360                 365             


Asp Ser Thr Ser Gly Gly Tyr Trp Glu Gln Val Ile Pro Ala Gly Gly 
    370                 375                 380                 


Arg Pro Pro Ala Ala Thr Gly His Ser Met Val Phe His Ala Pro Ser 
385                 390                 395                 400 


Arg Ala Leu Leu Val His Gly Gly His Arg Pro Ser Thr Ala Arg Phe 
                405                 410                 415     


Ser Val Arg Val Asn Ser Thr Glu Leu Phe His Val Asp Arg His Val 
            420                 425                 430         


Trp Thr Thr Leu Lys Gly Arg Asp Gly Leu Gln Gly Pro Arg Glu Arg 
        435                 440                 445             


Ala Phe His Thr Ala Ser Val Leu Gly Asn Tyr Met Val Val Tyr Gly 
    450                 455                 460                 


Gly Asn Val His Thr His Tyr Gln Glu Glu Lys Cys Tyr Glu Asp Gly 
465                 470                 475                 480 


Ile Phe Phe Tyr His Leu Gly Cys His Gln Trp Val Ser Gly Ala Glu 
                485                 490                 495     


Leu Ala Pro Pro Gly Thr Pro Glu Gly Arg Ala Ala Pro Pro Ser Gly 
            500                 505                 510         


Arg Tyr Ser His Val Ala Ala Val Leu Gly Gly Ser Val Leu Leu Val 
        515                 520                 525             


Ala Gly Gly Tyr Ser Gly Arg Pro Arg Gly Asp Leu Met Ala Tyr Lys 
    530                 535                 540                 


Val Pro Pro Phe Val Phe Gln Ala Pro Ala Pro Asp Tyr His Leu Asp 
545                 550                 555                 560 


Tyr Cys Ser Met Tyr Thr Asp His Ser Val Cys Ser Arg Asp Pro Glu 
                565                 570                 575     


Cys Ser Trp Cys Gln Gly Ala Cys Gln Ala Ala Pro Pro Pro Gly Thr 
            580                 585                 590         


Pro Leu Gly Ala Cys Pro Ala Ala Ser Cys Leu Gly Leu Gly Arg Leu 
        595                 600                 605             


Leu Gly Asp Cys Gln Ala Cys Leu Ala Phe Ser Ser Pro Thr Ala Pro 
    610                 615                 620                 


Pro Arg Gly Pro Gly Thr Leu Gly Trp Cys Val His Asn Glu Ser Cys 
625                 630                 635                 640 


Leu Pro Arg Pro Glu Gln Ala Arg Cys Arg Gly Glu Gln Ile Ser Gly 
                645                 650                 655     


Thr Val Gly Trp Trp Gly Pro Ala Pro Val Phe Val Thr Ser Leu Glu 
            660                 665                 670         


Ala Cys Val Thr Gln Ser Phe Leu Pro Gly Leu His Leu Leu Thr Phe 
        675                 680                 685             


Gln Gln Pro Pro Asn Thr Ser Gln Pro Asp Lys Glu Glu Val Gly Arg 
    690                 695                 700                 


Trp Val Ala His Gln Glu Lys Glu Thr Arg Arg Leu Gln Arg Pro Gly 
705                 710                 715                 720 


Ser Ala Arg Leu Phe Pro Leu Pro Gly Arg Asp His Lys Tyr Ala Val 
                725                 730                 735     


Glu Ile Gln Gly Gln Leu Asn Gly Ser Ala Gly Pro Gly His Ser Glu 
            740                 745                 750         


Leu Thr Leu Leu Trp Asp Arg Thr Gly Val Pro Gly Gly Ser Glu Ile 
        755                 760                 765             


Ser Phe Phe Phe Leu Glu Pro Tyr Arg Ser Ser Ser Cys Thr Ser Tyr 
    770                 775                 780                 


Ser Ser Cys Leu Gly Cys Leu Ala Asp Gln Gly Cys Gly Trp Cys Leu 
785                 790                 795                 800 


Thr Ser Ala Thr Cys His Leu Arg Gln Gly Gly Ala His Cys Gly Asp 
                805                 810                 815     


Asp Gly Ala Gly Gly Ser Leu Leu Val Leu Val Pro Thr Leu Cys Pro 
            820                 825                 830         


Leu Cys Glu Glu His Arg Asp Cys His Ala Cys Thr Gln Asp Pro Phe 
        835                 840                 845             


Cys Glu Trp His Gln Ser Thr Ser Arg Lys Gly Asp Ala Ala Cys Ser 
    850                 855                 860                 


Arg Arg Gly Arg Gly Arg Gly Ala Leu Lys Ser Pro Glu Glu Cys Pro 
865                 870                 875                 880 


Pro Leu Cys Ser Gln Arg Leu Thr Cys Glu Asp Cys Leu Ala Asn Ser 
                885                 890                 895     


Ser Gln Cys Ala Trp Cys Gln Ser Thr His Thr Cys Phe Leu Phe Ala 
            900                 905                 910         


Ala Tyr Leu Ala Arg Tyr Pro His Gly Gly Cys Arg Gly Trp Asp Asp 
        915                 920                 925             


Ser Val His Ser Glu Pro Arg Cys Arg Ser Cys Asp Gly Phe Leu Thr 
    930                 935                 940                 


Cys His Glu Cys Leu Gln Ser His Glu Cys Gly Trp Cys Gly Asn Glu 
945                 950                 955                 960 


Asp Asn Pro Thr Leu Gly Arg Cys Leu Gln Gly Asp Phe Ser Gly Pro 
                965                 970                 975     


Leu Gly Gly Gly Asn Cys Ser Leu Trp Val Gly Glu Gly Leu Gly Leu 
            980                 985                 990         


Pro Val Ala Leu Pro Ala Arg Trp  Ala Tyr Ala Arg Cys  Pro Asp Val 
        995                 1000                 1005             


Asp Glu  Cys Arg Leu Gly Leu  Ala Arg Cys His Pro  Arg Ala Thr 
    1010                 1015                 1020             


Cys Leu  Asn Thr Pro Leu Ser  Tyr Glu Cys His Cys  Gln Arg Gly 
    1025                 1030                 1035             


Tyr Gln  Gly Asp Gly Ile Ser  His Cys Asn Arg Thr  Cys Leu Glu 
    1040                 1045                 1050             


Asp Cys  Gly His Gly Val Cys  Ser Gly Pro Pro Asp  Phe Thr Cys 
    1055                 1060                 1065             


Val Cys  Asp Leu Gly Trp Thr  Ser Asp Leu Pro Pro  Pro Thr Pro 
    1070                 1075                 1080             


Ala Pro  Gly Pro Pro Ala Pro  Arg Cys Ser Arg Asp  Cys Gly Cys 
    1085                 1090                 1095             


Ser Phe  His Ser His Cys Arg  Lys Arg Gly Pro Gly  Phe Cys Asp 
    1100                 1105                 1110             


Glu Cys  Gln Asp Trp Thr Trp  Gly Glu His Cys Glu  Arg Cys Arg 
    1115                 1120                 1125             


Pro Gly  Ser Phe Gly Asn Ala  Thr Gly Ser Arg Gly  Cys Arg Pro 
    1130                 1135                 1140             


Cys Gln  Cys Asn Gly His Gly  Asp Pro Arg Arg Gly  His Cys Asp 
    1145                 1150                 1155             


Asn Leu  Ser Gly Leu Cys Phe  Cys Gln Asp His Thr  Glu Gly Ala 
    1160                 1165                 1170             


His Cys  Gln Leu Cys Ser Pro  Gly Tyr Tyr Gly Asp  Pro Arg Ala 
    1175                 1180                 1185             


Gly Gly  Ser Cys Phe Arg Glu  Cys Gly Gly Arg Ala  Leu Leu Thr 
    1190                 1195                 1200             


Asn Val  Ser Ser Val Ala Leu  Gly Ser Arg Arg Val  Gly Gly Leu 
    1205                 1210                 1215             


Leu Pro  Pro Gly Gly Gly Ala  Ala Arg Ala Gly Pro  Gly Leu Ser 
    1220                 1225                 1230             


Tyr Cys  Val Trp Val Val Ser  Ala Thr Glu Glu Leu  Gln Pro Cys 
    1235                 1240                 1245             


Ala Pro  Gly Thr Leu Cys Pro  Pro Leu Thr Leu Thr  Phe Ser Pro 
    1250                 1255                 1260             


Asp Ser  Ser Thr Pro Cys Thr  Leu Ser Tyr Val Leu  Ala Phe Asp 
    1265                 1270                 1275             


Gly Phe  Pro Arg Phe Leu Asp  Thr Gly Val Val Gln  Ser Asp Arg 
    1280                 1285                 1290             


Ser Leu  Ile Ala Ala Phe Cys  Gly Gln Arg Arg Asp  Arg Pro Leu 
    1295                 1300                 1305             


Thr Val  Gln Ala Leu Ser Gly  Leu Leu Val Leu His  Trp Glu Ala 
    1310                 1315                 1320             


Asn Gly  Ser Ser Ser Trp Gly  Phe Asn Ala Ser Val  Gly Ser Ala 
    1325                 1330                 1335             


Arg Cys  Gly Ser Gly Gly Pro  Gly Ser Cys Pro Val  Pro Gln Glu 
    1340                 1345                 1350             


Cys Val  Pro Gln Asp Gly Ala  Ala Gly Ala Gly Leu  Cys Arg Cys 
    1355                 1360                 1365             


Pro Gln  Gly Trp Ala Gly Pro  His Cys Arg Met Ala  Leu Cys Pro 
    1370                 1375                 1380             


Glu Asn  Cys Asn Ala His Thr  Gly Ala Gly Thr Cys  Asn Gln Ser 
    1385                 1390                 1395             


Leu Gly  Val Cys Ile Cys Ala  Glu Gly Phe Gly Gly  Pro Asp Cys 
    1400                 1405                 1410             


Ala Thr  Lys Leu Asp Gly Gly  Gln Leu Val Trp Glu  Thr Leu Met 
    1415                 1420                 1425             


Asp Ser  Arg Leu Ser Ala Asp  Thr Ala Ser Arg Phe  Leu His Arg 
    1430                 1435                 1440             


Leu Gly  His Thr Met Val Asp  Gly Pro Asp Ala Thr  Leu Trp Met 
    1445                 1450                 1455             


Phe Gly  Gly Leu Gly Leu Pro  Gln Gly Leu Leu Gly  Asn Leu Tyr 
    1460                 1465                 1470             


Arg Tyr  Ser Val Ser Glu Arg  Arg Trp Thr Gln Met  Leu Ala Gly 
    1475                 1480                 1485             


Ala Glu  Asp Gly Gly Pro Gly  Pro Ser Pro Arg Ser  Phe His Ala 
    1490                 1495                 1500             


Ala Ala  Tyr Val Pro Ala Gly  Arg Gly Ala Met Tyr  Leu Leu Gly 
    1505                 1510                 1515             


Gly Leu  Thr Ala Gly Gly Val  Thr Arg Asp Phe Trp  Val Leu Asn 
    1520                 1525                 1530             


Leu Thr  Thr Leu Gln Trp Arg  Gln Glu Lys Ala Pro  Gln Thr Val 
    1535                 1540                 1545             


Glu Leu  Pro Ala Val Ala Gly  His Thr Leu Thr Ala  Arg Arg Gly 
    1550                 1555                 1560             


Leu Ser  Leu Leu Leu Val Gly  Gly Tyr Ser Pro Glu  Asn Gly Phe 
    1565                 1570                 1575             


Asn Gln  Gln Leu Leu Glu Tyr  Gln Leu Ala Thr Gly  Thr Trp Val 
    1580                 1585                 1590             


Ser Gly  Ala Gln Ser Gly Thr  Pro Pro Thr Gly Leu  Tyr Gly His 
    1595                 1600                 1605             


Ser Ala  Val Tyr His Glu Ala  Thr Asp Ser Leu Tyr  Val Phe Gly 
    1610                 1615                 1620             


Gly Phe  Arg Phe His Val Glu  Leu Ala Ala Pro Ser  Pro Glu Leu 
    1625                 1630                 1635             


Tyr Ser  Leu His Cys Pro Asp  Arg Thr Trp Ser Leu  Leu Ala Pro 
    1640                 1645                 1650             


Ser Gln  Gly Ala Lys Arg Asp  Arg Met Arg Asn Val  Arg Gly Ser 
    1655                 1660                 1665             


Ser Arg  Gly Leu Gly Gln Val  Pro Gly Glu Gln Pro  Gly Ser Trp 
    1670                 1675                 1680             


Gly Phe  Arg Glu Val Arg Lys  Lys Met Ala Leu Trp  Ala Ala Leu 
    1685                 1690                 1695             


Ala Gly  Thr Gly Gly Phe Leu  Glu Glu Ile Ser Pro  His Leu Lys 
    1700                 1705                 1710             


Glu Pro  Arg Pro Arg Leu Phe  His Ala Ser Ala Leu  Leu Gly Asp 
    1715                 1720                 1725             


Thr Met  Val Val Leu Gly Gly  Arg Ser Asp Pro Asp  Glu Phe Ser 
    1730                 1735                 1740             


Ser Asp  Val Leu Leu Tyr Gln  Val Asn Cys Asn Ala  Trp Leu Leu 
    1745                 1750                 1755             


Pro Asp  Leu Thr Arg Ser Ala  Ser Val Gly Pro Pro  Met Glu Glu 
    1760                 1765                 1770             


Ser Val  Ala His Ala Val Ala  Ala Val Gly Ser Arg  Leu Tyr Ile 
    1775                 1780                 1785             


Ser Gly  Gly Phe Gly Gly Val  Ala Leu Gly Arg Leu  Leu Ala Leu 
    1790                 1795                 1800             


Thr Leu  Pro Pro Asp Pro Cys  Arg Leu Leu Ser Ser  Pro Glu Ala 
    1805                 1810                 1815             


Cys Asn  Gln Ser Gly Ala Cys  Thr Trp Cys His Gly  Ala Cys Leu 
    1820                 1825                 1830             


Ser Gly  Asp Gln Ala His Arg  Leu Gly Cys Gly Gly  Ser Pro Cys 
    1835                 1840                 1845             


Ser Pro  Met Pro Arg Ser Pro  Glu Glu Cys Arg Arg  Leu Arg Thr 
    1850                 1855                 1860             


Cys Ser  Glu Cys Leu Ala Arg  His Pro Arg Thr Leu  Gln Pro Gly 
    1865                 1870                 1875             


Asp Gly  Glu Ala Ser Thr Pro  Arg Cys Lys Trp Cys  Thr Asn Cys 
    1880                 1885                 1890             


Pro Glu  Gly Ala Cys Ile Gly  Arg Asn Gly Ser Cys  Thr Ser Glu 
    1895                 1900                 1905             


Asn Asp  Cys Arg Ile Asn Gln  Arg Glu Val Phe Trp  Ala Gly Asn 
    1910                 1915                 1920             


Cys Ser  Glu Ala Ala Cys Gly  Ala Ala Asp Cys Glu  Gln Cys Thr 
    1925                 1930                 1935             


Arg Glu  Gly Lys Cys Met Trp  Thr Arg Gln Phe Lys  Arg Thr Gly 
    1940                 1945                 1950             


Glu Thr  Arg Arg Ile Leu Ser  Val Gln Pro Thr Tyr  Asp Trp Thr 
    1955                 1960                 1965             


Cys Phe  Ser His Ser Leu Leu  Asn Val Ser Pro Met  Pro Val Glu 
    1970                 1975                 1980             


Ser Ser  Pro Pro Leu Pro Cys  Pro Thr Pro Cys His  Leu Leu Pro 
    1985                 1990                 1995             


Asn Cys  Thr Ser Cys Leu Asp  Ser Lys Gly Ala Asp  Gly Gly Trp 
    2000                 2005                 2010             


Gln His  Cys Val Trp Ser Ser  Ser Leu Gln Gln Cys  Leu Ser Pro 
    2015                 2020                 2025             


Ser Tyr  Leu Pro Leu Arg Cys  Met Ala Gly Gly Cys  Gly Arg Leu 
    2030                 2035                 2040             


Leu Arg  Gly Pro Glu Ser Cys  Ser Leu Gly Cys Ala  Gln Ala Thr 
    2045                 2050                 2055             


Gln Cys  Ala Leu Cys Leu Arg  Arg Pro His Cys Gly  Trp Cys Ala 
    2060                 2065                 2070             


Trp Gly  Gly Gln Asp Gly Gly  Gly Arg Cys Met Glu  Gly Gly Leu 
    2075                 2080                 2085             


Ser Gly  Pro Arg Asp Gly Leu  Thr Cys Gly Arg Pro  Gly Ala Ser 
    2090                 2095                 2100             


Trp Ala  Phe Leu Ser Cys Pro  Pro Glu Asp Glu Cys  Ala Asn Gly 
    2105                 2110                 2115             


His His  Asp Cys Asn Glu Thr  Gln Asn Cys His Asp  Gln Pro His 
    2120                 2125                 2130             


Gly Tyr  Glu Cys Ser Cys Lys  Thr Gly Tyr Thr Met  Asp Asn Met 
    2135                 2140                 2145             


Thr Gly  Leu Cys Arg Pro Val  Cys Ala Gln Gly Cys  Val Asn Gly 
    2150                 2155                 2160             


Ser Cys  Val Glu Pro Asp His  Cys Arg Cys His Phe  Gly Phe Val 
    2165                 2170                 2175             


Gly Arg  Asn Cys Ser Thr Glu  Cys Arg Cys Asn Arg  His Ser Glu 
    2180                 2185                 2190             


Cys Ala  Gly Val Gly Ala Arg  Asp His Cys Leu Leu  Cys Arg Asn 
    2195                 2200                 2205             


His Thr  Lys Gly Ser His Cys  Glu Gln Cys Leu Pro  Leu Phe Val 
    2210                 2215                 2220             


Gly Ser  Ala Val Gly Gly Gly  Thr Cys Arg Pro Cys  His Ala Phe 
    2225                 2230                 2235             


Cys Arg  Gly Asn Ser His Ile  Cys Ile Ser Arg Lys  Glu Leu Gln 
    2240                 2245                 2250             


Met Ser  Lys Gly Glu Pro Lys  Lys Tyr Ser Leu Asp  Pro Glu Glu 
    2255                 2260                 2265             


Ile Glu  Asn Trp Val Thr Glu  Gly Pro Ser Glu Asp  Glu Ala Val 
    2270                 2275                 2280             


Cys Val  Asn Cys Gln Asn Asn  Ser Tyr Gly Glu Lys  Cys Glu Ser 
    2285                 2290                 2295             


Cys Leu  Gln Gly Tyr Phe Leu  Leu Asp Gly Lys Cys  Thr Lys Cys 
    2300                 2305                 2310             


Gln Cys  Asn Gly His Ala Asp  Thr Cys Asn Glu Gln  Asp Gly Thr 
    2315                 2320                 2325             


Gly Cys  Pro Cys Gln Asn Asn  Thr Glu Thr Gly Thr  Cys Gln Gly 
    2330                 2335                 2340             


Ser Ser  Pro Ser Asp Arg Arg  Asp Cys Tyr Lys Tyr  Gln Cys Ala 
    2345                 2350                 2355             


Lys Cys  Arg Glu Ser Phe His  Gly Ser Pro Leu Gly  Gly Gln Gln 
    2360                 2365                 2370             


Cys Tyr  Arg Leu Ile Ser Val  Glu Gln Glu Cys Cys  Leu Asp Pro 
    2375                 2380                 2385             


Thr Ser  Gln Thr Asn Cys Phe  His Glu Pro Lys Arg  Arg Ala Leu 
    2390                 2395                 2400             


Gly Pro  Gly Arg Thr Val Leu  Phe Gly Val Gln Pro  Lys Phe Thr 
    2405                 2410                 2415             


Asn Val  Asp Ile Arg Leu Thr  Leu Asp Val Thr Phe  Gly Ala Val 
    2420                 2425                 2430             


Asp Leu  Tyr Val Ser Thr Ser  Tyr Asp Thr Phe Val  Val Arg Val 
    2435                 2440                 2445             


Ala Pro  Asp Thr Gly Val His  Thr Val His Ile Gln  Pro Pro Pro 
    2450                 2455                 2460             


Ala Pro  Pro Pro Pro Pro Pro  Pro Ala Asp Gly Gly  Pro Arg Gly 
    2465                 2470                 2475             


Ala Gly  Asp Pro Gly Gly Ala  Gly Ala Ser Ser Gly  Pro Gly Ala 
    2480                 2485                 2490             


Pro Ala  Glu Pro Arg Val Arg  Glu Val Trp Pro Arg  Gly Leu Ile 
    2495                 2500                 2505             


Thr Tyr  Val Thr Val Thr Glu  Pro Ser Ala Val Leu  Val Val Arg 
    2510                 2515                 2520             


Gly Val  Arg Asp Arg Leu Val  Ile Thr Tyr Pro His  Glu His His 
    2525                 2530                 2535             


Ala Leu  Lys Ser Ser Arg Phe  Tyr Leu Leu Leu Leu  Gly Val Gly 
    2540                 2545                 2550             


Asp Pro  Ser Gly Pro Gly Ala  Asn Gly Ser Ala Asp  Ser Gln Gly 
    2555                 2560                 2565             


Leu Leu  Phe Phe Arg Gln Asp  Gln Ala His Ile Asp  Leu Phe Val 
    2570                 2575                 2580             


Phe Phe  Ser Val Phe Phe Ser  Cys Phe Phe Leu Phe  Leu Ser Leu 
    2585                 2590                 2595             


Cys Val  Leu Leu Trp Lys Ala  Lys Gln Ala Leu Asp  Gln Arg Gln 
    2600                 2605                 2610             


Glu Gln  Arg Arg His Leu Gln  Glu Met Thr Lys Met  Ala Ser Arg 
    2615                 2620                 2625             


Pro Phe  Ala Lys Val Thr Val  Cys Phe Pro Pro Asp  Pro Thr Ala 
    2630                 2635                 2640             


Pro Ala  Ser Ala Trp Lys Pro  Ala Gly Leu Pro Pro  Pro Ala Phe 
    2645                 2650                 2655             


Arg Arg  Ser Glu Pro Phe Leu  Ala Pro Leu Leu Leu  Thr Gly Ala 
    2660                 2665                 2670             


Gly Gly  Pro Trp Gly Pro Met  Gly Gly Gly Cys Cys  Pro Pro Ala 
    2675                 2680                 2685             


Ile Pro  Ala Thr Thr Ala Gly  Leu Arg Ala Gly Pro  Ile Thr Leu 
    2690                 2695                 2700             


Glu Pro  Thr Glu Asp Gly Met  Ala Gly Val Ala Thr  Leu Leu Leu 
    2705                 2710                 2715             


Gln Leu  Pro Gly Gly Pro His  Ala Pro Asn Gly Ala  Cys Leu Gly 
    2720                 2725                 2730             


Ser Ala  Leu Val Thr Leu Arg  His Arg Leu His Glu  Tyr Cys Gly 
    2735                 2740                 2745             


Gly Gly  Gly Gly Ala Gly Gly  Ser Gly His Gly Thr  Gly Ala Gly 
    2750                 2755                 2760             


Arg Lys  Gly Leu Leu Ser Gln  Asp Asn Leu Thr Ser  Met Ser Leu 
    2765                 2770                 2775             


<210>  42
<211>  2319
<212>  PRT
<213>  Homo sapiens

<400>  42

Met Val Val Tyr Gly Gly Asn Val His Thr His Tyr Gln Glu Glu Lys 
1               5                   10                  15      


Cys Tyr Glu Asp Gly Ile Phe Phe Tyr His Leu Gly Cys His Gln Trp 
            20                  25                  30          


Val Ser Gly Ala Glu Leu Ala Pro Pro Gly Thr Pro Glu Gly Arg Ala 
        35                  40                  45              


Ala Pro Pro Ser Gly Arg Tyr Ser His Val Ala Ala Val Leu Gly Gly 
    50                  55                  60                  


Ser Val Leu Leu Val Ala Gly Gly Tyr Ser Gly Arg Pro Arg Gly Asp 
65                  70                  75                  80  


Leu Met Ala Tyr Lys Val Pro Pro Phe Val Phe Gln Ala Pro Ala Pro 
                85                  90                  95      


Asp Tyr His Leu Asp Tyr Cys Ser Met Tyr Thr Asp His Ser Val Cys 
            100                 105                 110         


Ser Arg Asp Pro Glu Cys Ser Trp Cys Gln Gly Ala Cys Gln Ala Ala 
        115                 120                 125             


Pro Pro Pro Gly Thr Pro Leu Gly Ala Cys Pro Ala Ala Ser Cys Leu 
    130                 135                 140                 


Gly Leu Gly Arg Leu Leu Gly Asp Cys Gln Ala Cys Leu Ala Phe Ser 
145                 150                 155                 160 


Ser Pro Thr Ala Pro Pro Arg Gly Pro Gly Thr Leu Gly Trp Cys Val 
                165                 170                 175     


His Asn Glu Ser Cys Leu Pro Arg Pro Glu Gln Ala Arg Cys Arg Gly 
            180                 185                 190         


Glu Gln Ile Ser Gly Thr Val Gly Trp Trp Gly Pro Ala Pro Val Phe 
        195                 200                 205             


Val Thr Ser Leu Glu Ala Cys Val Thr Gln Ser Phe Leu Pro Gly Leu 
    210                 215                 220                 


His Leu Leu Thr Phe Gln Gln Pro Pro Asn Thr Ser Gln Pro Asp Lys 
225                 230                 235                 240 


Glu Glu Val Gly Arg Trp Val Ala His Gln Glu Lys Glu Thr Arg Arg 
                245                 250                 255     


Leu Gln Arg Pro Gly Ser Ala Arg Leu Phe Pro Leu Pro Gly Arg Asp 
            260                 265                 270         


His Lys Tyr Ala Val Glu Ile Gln Gly Gln Leu Asn Gly Ser Ala Gly 
        275                 280                 285             


Pro Gly His Ser Glu Leu Thr Leu Leu Trp Asp Arg Thr Gly Val Pro 
    290                 295                 300                 


Gly Gly Ser Glu Ile Ser Phe Phe Phe Leu Glu Pro Tyr Arg Ser Ser 
305                 310                 315                 320 


Ser Cys Thr Ser Tyr Ser Ser Cys Leu Gly Cys Leu Ala Asp Gln Gly 
                325                 330                 335     


Cys Gly Trp Cys Leu Thr Ser Ala Thr Cys His Leu Arg Gln Gly Gly 
            340                 345                 350         


Ala His Cys Gly Asp Asp Gly Ala Gly Gly Ser Leu Leu Val Leu Val 
        355                 360                 365             


Pro Thr Leu Cys Pro Leu Cys Glu Glu His Arg Asp Cys His Ala Cys 
    370                 375                 380                 


Thr Gln Asp Pro Phe Cys Glu Trp His Gln Ser Thr Ser Arg Lys Gly 
385                 390                 395                 400 


Asp Ala Ala Cys Ser Arg Arg Gly Arg Gly Arg Gly Ala Leu Lys Ser 
                405                 410                 415     


Pro Glu Glu Cys Pro Pro Leu Cys Ser Gln Arg Leu Thr Cys Glu Asp 
            420                 425                 430         


Cys Leu Ala Asn Ser Ser Gln Cys Ala Trp Cys Gln Ser Thr His Thr 
        435                 440                 445             


Cys Phe Leu Phe Ala Ala Tyr Leu Ala Arg Tyr Pro His Gly Gly Cys 
    450                 455                 460                 


Arg Gly Trp Asp Asp Ser Val His Ser Glu Pro Arg Cys Arg Ser Cys 
465                 470                 475                 480 


Asp Gly Phe Leu Thr Cys His Glu Cys Leu Gln Ser His Glu Cys Gly 
                485                 490                 495     


Trp Cys Gly Asn Glu Asp Asn Pro Thr Leu Gly Arg Cys Leu Gln Gly 
            500                 505                 510         


Asp Phe Ser Gly Pro Leu Gly Gly Gly Asn Cys Ser Leu Trp Val Gly 
        515                 520                 525             


Glu Gly Leu Gly Leu Pro Val Ala Leu Pro Ala Arg Trp Ala Tyr Ala 
    530                 535                 540                 


Arg Cys Pro Asp Val Asp Glu Cys Arg Leu Gly Leu Ala Arg Cys His 
545                 550                 555                 560 


Pro Arg Ala Thr Cys Leu Asn Thr Pro Leu Ser Tyr Glu Cys His Cys 
                565                 570                 575     


Gln Arg Gly Tyr Gln Gly Asp Gly Ile Ser His Cys Asn Arg Thr Cys 
            580                 585                 590         


Leu Glu Asp Cys Gly His Gly Val Cys Ser Gly Pro Pro Asp Phe Thr 
        595                 600                 605             


Cys Val Cys Asp Leu Gly Trp Thr Ser Asp Leu Pro Pro Pro Thr Pro 
    610                 615                 620                 


Ala Pro Gly Pro Pro Ala Pro Arg Cys Ser Arg Asp Cys Gly Cys Ser 
625                 630                 635                 640 


Phe His Ser His Cys Arg Lys Arg Gly Pro Gly Phe Cys Asp Glu Cys 
                645                 650                 655     


Gln Asp Trp Thr Trp Gly Glu His Cys Glu Arg Cys Arg Pro Gly Ser 
            660                 665                 670         


Phe Gly Asn Ala Thr Gly Ser Arg Gly Cys Arg Pro Cys Gln Cys Asn 
        675                 680                 685             


Gly His Gly Asp Pro Arg Arg Gly His Cys Asp Asn Leu Ser Gly Leu 
    690                 695                 700                 


Cys Phe Cys Gln Asp His Thr Glu Gly Ala His Cys Gln Leu Cys Ser 
705                 710                 715                 720 


Pro Gly Tyr Tyr Gly Asp Pro Arg Ala Gly Gly Ser Cys Phe Arg Glu 
                725                 730                 735     


Cys Gly Gly Arg Ala Leu Leu Thr Asn Val Ser Ser Val Ala Leu Gly 
            740                 745                 750         


Ser Arg Arg Val Gly Gly Leu Leu Pro Pro Gly Gly Gly Ala Ala Arg 
        755                 760                 765             


Ala Gly Pro Gly Leu Ser Tyr Cys Val Trp Val Val Ser Ala Thr Glu 
    770                 775                 780                 


Glu Leu Gln Pro Cys Ala Pro Gly Thr Leu Cys Pro Pro Leu Thr Leu 
785                 790                 795                 800 


Thr Phe Ser Pro Asp Ser Ser Thr Pro Cys Thr Leu Ser Tyr Val Leu 
                805                 810                 815     


Ala Phe Asp Gly Phe Pro Arg Phe Leu Asp Thr Gly Val Val Gln Ser 
            820                 825                 830         


Asp Arg Ser Leu Ile Ala Ala Phe Cys Gly Gln Arg Arg Asp Arg Pro 
        835                 840                 845             


Leu Thr Val Gln Ala Leu Ser Gly Leu Leu Val Leu His Trp Glu Ala 
    850                 855                 860                 


Asn Gly Ser Ser Ser Trp Gly Phe Asn Ala Ser Val Gly Ser Ala Arg 
865                 870                 875                 880 


Cys Gly Ser Gly Gly Pro Gly Ser Cys Pro Val Pro Gln Glu Cys Val 
                885                 890                 895     


Pro Gln Asp Gly Ala Ala Gly Ala Gly Leu Cys Arg Cys Pro Gln Gly 
            900                 905                 910         


Trp Ala Gly Pro His Cys Arg Met Ala Leu Cys Pro Glu Asn Cys Asn 
        915                 920                 925             


Ala His Thr Gly Ala Gly Thr Cys Asn Gln Ser Leu Gly Val Cys Ile 
    930                 935                 940                 


Cys Ala Glu Gly Phe Gly Gly Pro Asp Cys Ala Thr Lys Leu Asp Gly 
945                 950                 955                 960 


Gly Gln Leu Val Trp Glu Thr Leu Met Asp Ser Arg Leu Ser Ala Asp 
                965                 970                 975     


Thr Ala Ser Arg Phe Leu His Arg Leu Gly His Thr Met Val Asp Gly 
            980                 985                 990         


Pro Asp Ala Thr Leu Trp Met Phe  Gly Gly Leu Gly Leu  Pro Gln Gly 
        995                 1000                 1005             


Leu Leu  Gly Asn Leu Tyr Arg  Tyr Ser Val Ser Glu  Arg Arg Trp 
    1010                 1015                 1020             


Thr Gln  Met Leu Ala Gly Ala  Glu Asp Gly Gly Pro  Gly Pro Ser 
    1025                 1030                 1035             


Pro Arg  Ser Phe His Ala Ala  Ala Tyr Val Pro Ala  Gly Arg Gly 
    1040                 1045                 1050             


Ala Met  Tyr Leu Leu Gly Gly  Leu Thr Ala Gly Gly  Val Thr Arg 
    1055                 1060                 1065             


Asp Phe  Trp Val Leu Asn Leu  Thr Thr Leu Gln Trp  Arg Gln Glu 
    1070                 1075                 1080             


Lys Ala  Pro Gln Thr Val Glu  Leu Pro Ala Val Ala  Gly His Thr 
    1085                 1090                 1095             


Leu Thr  Ala Arg Arg Gly Leu  Ser Leu Leu Leu Val  Gly Gly Tyr 
    1100                 1105                 1110             


Ser Pro  Glu Asn Gly Phe Asn  Gln Gln Leu Leu Glu  Tyr Gln Leu 
    1115                 1120                 1125             


Ala Thr  Gly Thr Trp Val Ser  Gly Ala Gln Ser Gly  Thr Pro Pro 
    1130                 1135                 1140             


Thr Gly  Leu Tyr Gly His Ser  Ala Val Tyr His Glu  Ala Thr Asp 
    1145                 1150                 1155             


Ser Leu  Tyr Val Phe Gly Gly  Phe Arg Phe His Val  Glu Leu Ala 
    1160                 1165                 1170             


Ala Pro  Ser Pro Glu Leu Tyr  Ser Leu His Cys Pro  Asp Arg Thr 
    1175                 1180                 1185             


Trp Ser  Leu Leu Ala Pro Ser  Gln Gly Ala Lys Arg  Asp Arg Met 
    1190                 1195                 1200             


Arg Asn  Val Arg Gly Ser Ser  Arg Gly Leu Gly Gln  Val Pro Gly 
    1205                 1210                 1215             


Glu Gln  Pro Gly Ser Trp Gly  Phe Arg Glu Val Arg  Lys Lys Met 
    1220                 1225                 1230             


Ala Leu  Trp Ala Ala Leu Ala  Gly Thr Gly Gly Phe  Leu Glu Glu 
    1235                 1240                 1245             


Ile Ser  Pro His Leu Lys Glu  Pro Arg Pro Arg Leu  Phe His Ala 
    1250                 1255                 1260             


Ser Ala  Leu Leu Gly Asp Thr  Met Val Val Leu Gly  Gly Arg Ser 
    1265                 1270                 1275             


Asp Pro  Asp Glu Phe Ser Ser  Asp Val Leu Leu Tyr  Gln Val Asn 
    1280                 1285                 1290             


Cys Asn  Ala Trp Leu Leu Pro  Asp Leu Thr Arg Ser  Ala Ser Val 
    1295                 1300                 1305             


Gly Pro  Pro Met Glu Glu Ser  Val Ala His Ala Val  Ala Ala Val 
    1310                 1315                 1320             


Gly Ser  Arg Leu Tyr Ile Ser  Gly Gly Phe Gly Gly  Val Ala Leu 
    1325                 1330                 1335             


Gly Arg  Leu Leu Ala Leu Thr  Leu Pro Pro Asp Pro  Cys Arg Leu 
    1340                 1345                 1350             


Leu Ser  Ser Pro Glu Ala Cys  Asn Gln Ser Gly Ala  Cys Thr Trp 
    1355                 1360                 1365             


Cys His  Gly Ala Cys Leu Ser  Gly Asp Gln Ala His  Arg Leu Gly 
    1370                 1375                 1380             


Cys Gly  Gly Ser Pro Cys Ser  Pro Met Pro Arg Ser  Pro Glu Glu 
    1385                 1390                 1395             


Cys Arg  Arg Leu Arg Thr Cys  Ser Glu Cys Leu Ala  Arg His Pro 
    1400                 1405                 1410             


Arg Thr  Leu Gln Pro Gly Asp  Gly Glu Ala Ser Thr  Pro Arg Cys 
    1415                 1420                 1425             


Lys Trp  Cys Thr Asn Cys Pro  Glu Gly Ala Cys Ile  Gly Arg Asn 
    1430                 1435                 1440             


Gly Ser  Cys Thr Ser Glu Asn  Asp Cys Arg Ile Asn  Gln Arg Glu 
    1445                 1450                 1455             


Val Phe  Trp Ala Gly Asn Cys  Ser Glu Ala Ala Cys  Gly Ala Ala 
    1460                 1465                 1470             


Asp Cys  Glu Gln Cys Thr Arg  Glu Gly Lys Cys Met  Trp Thr Arg 
    1475                 1480                 1485             


Gln Phe  Lys Arg Thr Gly Glu  Thr Arg Arg Ile Leu  Ser Val Gln 
    1490                 1495                 1500             


Pro Thr  Tyr Asp Trp Thr Cys  Phe Ser His Ser Leu  Leu Asn Val 
    1505                 1510                 1515             


Ser Pro  Met Pro Val Glu Ser  Ser Pro Pro Leu Pro  Cys Pro Thr 
    1520                 1525                 1530             


Pro Cys  His Leu Leu Pro Asn  Cys Thr Ser Cys Leu  Asp Ser Lys 
    1535                 1540                 1545             


Gly Ala  Asp Gly Gly Trp Gln  His Cys Val Trp Ser  Ser Ser Leu 
    1550                 1555                 1560             


Gln Gln  Cys Leu Ser Pro Ser  Tyr Leu Pro Leu Arg  Cys Met Ala 
    1565                 1570                 1575             


Gly Gly  Cys Gly Arg Leu Leu  Arg Gly Pro Glu Ser  Cys Ser Leu 
    1580                 1585                 1590             


Gly Cys  Ala Gln Ala Thr Gln  Cys Ala Leu Cys Leu  Arg Arg Pro 
    1595                 1600                 1605             


His Cys  Gly Trp Cys Ala Trp  Gly Gly Gln Asp Gly  Gly Gly Arg 
    1610                 1615                 1620             


Cys Met  Glu Gly Gly Leu Ser  Gly Pro Arg Asp Gly  Leu Thr Cys 
    1625                 1630                 1635             


Gly Arg  Pro Gly Ala Ser Trp  Ala Phe Leu Ser Cys  Pro Pro Glu 
    1640                 1645                 1650             


Asp Glu  Cys Ala Asn Gly His  His Asp Cys Asn Glu  Thr Gln Asn 
    1655                 1660                 1665             


Cys His  Asp Gln Pro His Gly  Tyr Glu Cys Ser Cys  Lys Thr Gly 
    1670                 1675                 1680             


Tyr Thr  Met Asp Asn Met Thr  Gly Leu Cys Arg Pro  Val Cys Ala 
    1685                 1690                 1695             


Gln Gly  Cys Val Asn Gly Ser  Cys Val Glu Pro Asp  His Cys Arg 
    1700                 1705                 1710             


Cys His  Phe Gly Phe Val Gly  Arg Asn Cys Ser Thr  Glu Cys Arg 
    1715                 1720                 1725             


Cys Asn  Arg His Ser Glu Cys  Ala Gly Val Gly Ala  Arg Asp His 
    1730                 1735                 1740             


Cys Leu  Leu Cys Arg Asn His  Thr Lys Gly Ser His  Cys Glu Gln 
    1745                 1750                 1755             


Cys Leu  Pro Leu Phe Val Gly  Ser Ala Val Gly Gly  Gly Thr Cys 
    1760                 1765                 1770             


Arg Pro  Cys His Ala Phe Cys  Arg Gly Asn Ser His  Ile Cys Ile 
    1775                 1780                 1785             


Ser Arg  Lys Glu Leu Gln Met  Ser Lys Gly Glu Pro  Lys Lys Tyr 
    1790                 1795                 1800             


Ser Leu  Asp Pro Glu Glu Ile  Glu Asn Trp Val Thr  Glu Gly Pro 
    1805                 1810                 1815             


Ser Glu  Asp Glu Ala Val Cys  Val Asn Cys Gln Asn  Asn Ser Tyr 
    1820                 1825                 1830             


Gly Glu  Lys Cys Glu Ser Cys  Leu Gln Gly Tyr Phe  Leu Leu Asp 
    1835                 1840                 1845             


Gly Lys  Cys Thr Lys Cys Gln  Cys Asn Gly His Ala  Asp Thr Cys 
    1850                 1855                 1860             


Asn Glu  Gln Asp Gly Thr Gly  Cys Pro Cys Gln Asn  Asn Thr Glu 
    1865                 1870                 1875             


Thr Gly  Thr Cys Gln Gly Ser  Ser Pro Ser Asp Arg  Arg Asp Cys 
    1880                 1885                 1890             


Tyr Lys  Tyr Gln Cys Ala Lys  Cys Arg Glu Ser Phe  His Gly Ser 
    1895                 1900                 1905             


Pro Leu  Gly Gly Gln Gln Cys  Tyr Arg Leu Ile Ser  Val Glu Gln 
    1910                 1915                 1920             


Glu Cys  Cys Leu Asp Pro Thr  Ser Gln Thr Asn Cys  Phe His Glu 
    1925                 1930                 1935             


Pro Lys  Arg Arg Ala Leu Gly  Pro Gly Arg Thr Val  Leu Phe Gly 
    1940                 1945                 1950             


Val Gln  Pro Lys Phe Thr Asn  Val Asp Ile Arg Leu  Thr Leu Asp 
    1955                 1960                 1965             


Val Thr  Phe Gly Ala Val Asp  Leu Tyr Val Ser Thr  Ser Tyr Asp 
    1970                 1975                 1980             


Thr Phe  Val Val Arg Val Ala  Pro Asp Thr Gly Val  His Thr Val 
    1985                 1990                 1995             


His Ile  Gln Pro Pro Pro Ala  Pro Pro Pro Pro Pro  Pro Pro Ala 
    2000                 2005                 2010             


Asp Gly  Gly Pro Arg Gly Ala  Gly Asp Pro Gly Gly  Ala Gly Ala 
    2015                 2020                 2025             


Ser Ser  Gly Pro Gly Ala Pro  Ala Glu Pro Arg Val  Arg Glu Val 
    2030                 2035                 2040             


Trp Pro  Arg Gly Leu Ile Thr  Tyr Val Thr Val Thr  Glu Pro Ser 
    2045                 2050                 2055             


Ala Val  Leu Val Val Arg Gly  Val Arg Asp Arg Leu  Val Ile Thr 
    2060                 2065                 2070             


Tyr Pro  His Glu His His Ala  Leu Lys Ser Ser Arg  Phe Tyr Leu 
    2075                 2080                 2085             


Leu Leu  Leu Gly Val Gly Asp  Pro Ser Gly Pro Gly  Ala Asn Gly 
    2090                 2095                 2100             


Ser Ala  Asp Ser Gln Gly Leu  Leu Phe Phe Arg Gln  Asp Gln Ala 
    2105                 2110                 2115             


His Ile  Asp Leu Phe Val Phe  Phe Ser Val Phe Phe  Ser Cys Phe 
    2120                 2125                 2130             


Phe Leu  Phe Leu Ser Leu Cys  Val Leu Leu Trp Lys  Ala Lys Gln 
    2135                 2140                 2145             


Ala Leu  Asp Gln Arg Gln Glu  Gln Arg Arg His Leu  Gln Glu Met 
    2150                 2155                 2160             


Thr Lys  Met Ala Ser Arg Pro  Phe Ala Lys Val Thr  Val Cys Phe 
    2165                 2170                 2175             


Pro Pro  Asp Pro Thr Ala Pro  Ala Ser Ala Trp Lys  Pro Ala Gly 
    2180                 2185                 2190             


Leu Pro  Pro Pro Ala Phe Arg  Arg Ser Glu Pro Phe  Leu Ala Pro 
    2195                 2200                 2205             


Leu Leu  Leu Thr Gly Ala Gly  Gly Pro Trp Gly Pro  Met Gly Gly 
    2210                 2215                 2220             


Gly Cys  Cys Pro Pro Ala Ile  Pro Ala Thr Thr Ala  Gly Leu Arg 
    2225                 2230                 2235             


Ala Gly  Pro Ile Thr Leu Glu  Pro Thr Glu Asp Gly  Met Ala Gly 
    2240                 2245                 2250             


Val Ala  Thr Leu Leu Leu Gln  Leu Pro Gly Gly Pro  His Ala Pro 
    2255                 2260                 2265             


Asn Gly  Ala Cys Leu Gly Ser  Ala Leu Val Thr Leu  Arg His Arg 
    2270                 2275                 2280             


Leu His  Glu Tyr Cys Gly Gly  Gly Gly Gly Ala Gly  Gly Ser Gly 
    2285                 2290                 2295             


His Gly  Thr Gly Ala Gly Arg  Lys Gly Leu Leu Ser  Gln Asp Asn 
    2300                 2305                 2310             


Leu Thr  Ser Met Ser Leu 
    2315                 


<210>  43
<211>  2386
<212>  PRT
<213>  Homo sapiens

<400>  43

Met Val Val Tyr Gly Gly Asn Val His Thr His Tyr Gln Glu Glu Lys 
1               5                   10                  15      


Cys Tyr Glu Asp Gly Ile Phe Phe Tyr His Leu Gly Cys His Gln Trp 
            20                  25                  30          


Val Ser Gly Ala Glu Leu Ala Pro Pro Gly Thr Pro Glu Gly Arg Ala 
        35                  40                  45              


Ala Pro Pro Ser Gly Arg Tyr Ser His Val Ala Ala Val Leu Gly Gly 
    50                  55                  60                  


Ser Val Leu Leu Val Ala Gly Gly Tyr Ser Gly Arg Pro Arg Gly Asp 
65                  70                  75                  80  


Leu Met Ala Tyr Lys Val Pro Pro Phe Val Phe Gln Ala Pro Ala Pro 
                85                  90                  95      


Asp Tyr His Leu Asp Tyr Cys Ser Met Tyr Thr Asp His Ser Val Cys 
            100                 105                 110         


Ser Arg Asp Pro Glu Cys Ser Trp Cys Gln Gly Ala Cys Gln Ala Ala 
        115                 120                 125             


Pro Pro Pro Gly Thr Pro Leu Gly Ala Cys Pro Ala Ala Ser Cys Leu 
    130                 135                 140                 


Gly Leu Gly Arg Leu Leu Gly Asp Cys Gln Ala Cys Leu Ala Phe Ser 
145                 150                 155                 160 


Ser Pro Thr Ala Pro Pro Arg Gly Pro Gly Thr Leu Gly Trp Cys Val 
                165                 170                 175     


His Asn Glu Ser Cys Leu Pro Arg Pro Glu Gln Ala Arg Cys Arg Gly 
            180                 185                 190         


Glu Gln Ile Ser Gly Thr Val Gly Trp Trp Gly Pro Ala Pro Val Phe 
        195                 200                 205             


Val Thr Ser Leu Glu Ala Cys Val Thr Gln Ser Phe Leu Pro Gly Leu 
    210                 215                 220                 


His Leu Leu Thr Phe Gln Gln Pro Pro Asn Thr Ser Gln Pro Asp Lys 
225                 230                 235                 240 


Val Ser Ile Val Arg Ser Thr Thr Ile Thr Leu Thr Pro Ser Ala Glu 
                245                 250                 255     


Thr Asp Val Ser Leu Val Tyr Arg Gly Phe Ile Tyr Pro Met Leu Pro 
            260                 265                 270         


Gly Gly Pro Gly Gly Pro Gly Ala Glu Asp Val Ala Val Trp Thr Arg 
        275                 280                 285             


Ala Gln Arg Leu His Val Leu Ala Arg Met Ala Arg Gly Pro Asp Thr 
    290                 295                 300                 


Glu Asn Met Glu Glu Val Gly Arg Trp Val Ala His Gln Glu Lys Glu 
305                 310                 315                 320 


Thr Arg Arg Leu Gln Arg Pro Gly Ser Ala Arg Leu Phe Pro Leu Pro 
                325                 330                 335     


Gly Arg Asp His Lys Tyr Ala Val Glu Ile Gln Gly Gln Leu Asn Gly 
            340                 345                 350         


Ser Ala Gly Pro Gly His Ser Glu Leu Thr Leu Leu Trp Asp Arg Thr 
        355                 360                 365             


Gly Val Pro Gly Gly Ser Glu Ile Ser Phe Phe Phe Leu Glu Pro Tyr 
    370                 375                 380                 


Arg Ser Ser Ser Cys Thr Ser Tyr Ser Ser Cys Leu Gly Cys Leu Ala 
385                 390                 395                 400 


Asp Gln Gly Cys Gly Trp Cys Leu Thr Ser Ala Thr Cys His Leu Arg 
                405                 410                 415     


Gln Gly Gly Ala His Cys Gly Asp Asp Gly Ala Gly Gly Ser Leu Leu 
            420                 425                 430         


Val Leu Val Pro Thr Leu Cys Pro Leu Cys Glu Glu His Arg Asp Cys 
        435                 440                 445             


His Ala Cys Thr Gln Asp Pro Phe Cys Glu Trp His Gln Ser Thr Ser 
    450                 455                 460                 


Arg Lys Gly Asp Ala Ala Cys Ser Arg Arg Gly Arg Gly Arg Gly Ala 
465                 470                 475                 480 


Leu Lys Ser Pro Glu Glu Cys Pro Pro Leu Cys Ser Gln Arg Leu Thr 
                485                 490                 495     


Cys Glu Asp Cys Leu Ala Asn Ser Ser Gln Cys Ala Trp Cys Gln Ser 
            500                 505                 510         


Thr His Thr Cys Phe Leu Phe Ala Ala Tyr Leu Ala Arg Tyr Pro His 
        515                 520                 525             


Gly Gly Cys Arg Gly Trp Asp Asp Ser Val His Ser Glu Pro Arg Cys 
    530                 535                 540                 


Arg Ser Cys Asp Gly Phe Leu Thr Cys His Glu Cys Leu Gln Ser His 
545                 550                 555                 560 


Glu Cys Gly Trp Cys Gly Asn Glu Asp Asn Pro Thr Leu Gly Arg Cys 
                565                 570                 575     


Leu Gln Gly Asp Phe Ser Gly Pro Leu Gly Gly Gly Asn Cys Ser Leu 
            580                 585                 590         


Trp Val Gly Glu Gly Leu Gly Leu Pro Val Ala Leu Pro Ala Arg Trp 
        595                 600                 605             


Ala Tyr Ala Arg Cys Pro Asp Val Asp Glu Cys Arg Leu Gly Leu Ala 
    610                 615                 620                 


Arg Cys His Pro Arg Ala Thr Cys Leu Asn Thr Pro Leu Ser Tyr Glu 
625                 630                 635                 640 


Cys His Cys Gln Arg Gly Tyr Gln Gly Asp Gly Ile Ser His Cys Asn 
                645                 650                 655     


Arg Thr Cys Leu Glu Asp Cys Gly His Gly Val Cys Ser Gly Pro Pro 
            660                 665                 670         


Asp Phe Thr Cys Val Cys Asp Leu Gly Trp Thr Ser Asp Leu Pro Pro 
        675                 680                 685             


Pro Thr Pro Ala Pro Gly Pro Pro Ala Pro Arg Cys Ser Arg Asp Cys 
    690                 695                 700                 


Gly Cys Ser Phe His Ser His Cys Arg Lys Arg Gly Pro Gly Phe Cys 
705                 710                 715                 720 


Asp Glu Cys Gln Asp Trp Thr Trp Gly Glu His Cys Glu Arg Cys Arg 
                725                 730                 735     


Pro Gly Ser Phe Gly Asn Ala Thr Gly Ser Arg Gly Cys Arg Pro Cys 
            740                 745                 750         


Gln Cys Asn Gly His Gly Asp Pro Arg Arg Gly His Cys Asp Asn Leu 
        755                 760                 765             


Ser Gly Leu Cys Phe Cys Gln Asp His Thr Glu Gly Ala His Cys Gln 
    770                 775                 780                 


Leu Cys Ser Pro Gly Tyr Tyr Gly Asp Pro Arg Ala Gly Gly Ser Cys 
785                 790                 795                 800 


Phe Arg Glu Cys Gly Gly Arg Ala Leu Leu Thr Asn Val Ser Ser Val 
                805                 810                 815     


Ala Leu Gly Ser Arg Arg Val Gly Gly Leu Leu Pro Pro Gly Gly Gly 
            820                 825                 830         


Ala Ala Arg Ala Gly Pro Gly Leu Ser Tyr Cys Val Trp Val Val Ser 
        835                 840                 845             


Ala Thr Glu Glu Leu Gln Pro Cys Ala Pro Gly Thr Leu Cys Pro Pro 
    850                 855                 860                 


Leu Thr Leu Thr Phe Ser Pro Asp Ser Ser Thr Pro Cys Thr Leu Ser 
865                 870                 875                 880 


Tyr Val Leu Ala Phe Asp Gly Phe Pro Arg Phe Leu Asp Thr Gly Val 
                885                 890                 895     


Val Gln Ser Asp Arg Ser Leu Ile Ala Ala Phe Cys Gly Gln Arg Arg 
            900                 905                 910         


Asp Arg Pro Leu Thr Val Gln Ala Leu Ser Gly Leu Leu Val Leu His 
        915                 920                 925             


Trp Glu Ala Asn Gly Ser Ser Ser Trp Gly Phe Asn Ala Ser Val Gly 
    930                 935                 940                 


Ser Ala Arg Cys Gly Ser Gly Gly Pro Gly Ser Cys Pro Val Pro Gln 
945                 950                 955                 960 


Glu Cys Val Pro Gln Asp Gly Ala Ala Gly Ala Gly Leu Cys Arg Cys 
                965                 970                 975     


Pro Gln Gly Trp Ala Gly Pro His Cys Arg Met Ala Leu Cys Pro Glu 
            980                 985                 990         


Asn Cys Asn Ala His Thr Gly Ala  Gly Thr Cys Asn Gln  Ser Leu Gly 
        995                 1000                 1005             


Val Cys  Ile Cys Ala Glu Gly  Phe Gly Gly Pro Asp  Cys Ala Thr 
    1010                 1015                 1020             


Lys Leu  Asp Gly Gly Gln Leu  Val Trp Glu Thr Leu  Met Asp Ser 
    1025                 1030                 1035             


Arg Leu  Ser Ala Asp Thr Ala  Ser Arg Phe Leu His  Arg Leu Gly 
    1040                 1045                 1050             


His Thr  Met Val Asp Gly Pro  Asp Ala Thr Leu Trp  Met Phe Gly 
    1055                 1060                 1065             


Gly Leu  Gly Leu Pro Gln Gly  Leu Leu Gly Asn Leu  Tyr Arg Tyr 
    1070                 1075                 1080             


Ser Val  Ser Glu Arg Arg Trp  Thr Gln Met Leu Ala  Gly Ala Glu 
    1085                 1090                 1095             


Asp Gly  Gly Pro Gly Pro Ser  Pro Arg Ser Phe His  Ala Ala Ala 
    1100                 1105                 1110             


Tyr Val  Pro Ala Gly Arg Gly  Ala Met Tyr Leu Leu  Gly Gly Leu 
    1115                 1120                 1125             


Thr Ala  Gly Gly Val Thr Arg  Asp Phe Trp Val Leu  Asn Leu Thr 
    1130                 1135                 1140             


Thr Leu  Gln Trp Arg Gln Glu  Lys Ala Pro Gln Thr  Val Glu Leu 
    1145                 1150                 1155             


Pro Ala  Val Ala Gly His Thr  Leu Thr Ala Arg Arg  Gly Leu Ser 
    1160                 1165                 1170             


Leu Leu  Leu Val Gly Gly Tyr  Ser Pro Glu Asn Gly  Phe Asn Gln 
    1175                 1180                 1185             


Gln Leu  Leu Glu Tyr Gln Leu  Ala Thr Gly Thr Trp  Val Ser Gly 
    1190                 1195                 1200             


Ala Gln  Ser Gly Thr Pro Pro  Thr Gly Leu Tyr Gly  His Ser Ala 
    1205                 1210                 1215             


Val Tyr  His Glu Ala Thr Asp  Ser Leu Tyr Val Phe  Gly Gly Phe 
    1220                 1225                 1230             


Arg Phe  His Val Glu Leu Ala  Ala Pro Ser Pro Glu  Leu Tyr Ser 
    1235                 1240                 1245             


Leu His  Cys Pro Asp Arg Thr  Trp Ser Leu Leu Ala  Pro Ser Gln 
    1250                 1255                 1260             


Gly Ala  Lys Arg Asp Arg Met  Arg Asn Val Arg Gly  Ser Ser Arg 
    1265                 1270                 1275             


Gly Leu  Gly Gln Val Pro Gly  Glu Gln Pro Gly Ser  Trp Gly Phe 
    1280                 1285                 1290             


Arg Glu  Val Arg Lys Lys Met  Ala Leu Trp Ala Ala  Leu Ala Gly 
    1295                 1300                 1305             


Thr Gly  Gly Phe Leu Glu Glu  Ile Ser Pro His Leu  Lys Glu Pro 
    1310                 1315                 1320             


Arg Pro  Arg Leu Phe His Ala  Ser Ala Leu Leu Gly  Asp Thr Met 
    1325                 1330                 1335             


Val Val  Leu Gly Gly Arg Ser  Asp Pro Asp Glu Phe  Ser Ser Asp 
    1340                 1345                 1350             


Val Leu  Leu Tyr Gln Val Asn  Cys Asn Ala Trp Leu  Leu Pro Asp 
    1355                 1360                 1365             


Leu Thr  Arg Ser Ala Ser Val  Gly Pro Pro Met Glu  Glu Ser Val 
    1370                 1375                 1380             


Ala His  Ala Val Ala Ala Val  Gly Ser Arg Leu Tyr  Ile Ser Gly 
    1385                 1390                 1395             


Gly Phe  Gly Gly Val Ala Leu  Gly Arg Leu Leu Ala  Leu Thr Leu 
    1400                 1405                 1410             


Pro Pro  Asp Pro Cys Arg Leu  Leu Ser Ser Pro Glu  Ala Cys Asn 
    1415                 1420                 1425             


Gln Ser  Gly Ala Cys Thr Trp  Cys His Gly Ala Cys  Leu Ser Gly 
    1430                 1435                 1440             


Asp Gln  Ala His Arg Leu Gly  Cys Gly Gly Ser Pro  Cys Ser Pro 
    1445                 1450                 1455             


Met Pro  Arg Ser Pro Glu Glu  Cys Arg Arg Leu Arg  Thr Cys Ser 
    1460                 1465                 1470             


Glu Cys  Leu Ala Arg His Pro  Arg Thr Leu Gln Pro  Gly Asp Gly 
    1475                 1480                 1485             


Glu Ala  Ser Thr Pro Arg Cys  Lys Trp Cys Thr Asn  Cys Pro Glu 
    1490                 1495                 1500             


Gly Ala  Cys Ile Gly Arg Asn  Gly Ser Cys Thr Ser  Glu Asn Asp 
    1505                 1510                 1515             


Cys Arg  Ile Asn Gln Arg Glu  Val Phe Trp Ala Gly  Asn Cys Ser 
    1520                 1525                 1530             


Glu Ala  Ala Cys Gly Ala Ala  Asp Cys Glu Gln Cys  Thr Arg Glu 
    1535                 1540                 1545             


Gly Lys  Cys Met Trp Thr Arg  Gln Phe Lys Arg Thr  Gly Glu Thr 
    1550                 1555                 1560             


Arg Arg  Ile Leu Ser Val Gln  Pro Thr Tyr Asp Trp  Thr Cys Phe 
    1565                 1570                 1575             


Ser His  Ser Leu Leu Asn Val  Ser Pro Met Pro Val  Glu Ser Ser 
    1580                 1585                 1590             


Pro Pro  Leu Pro Cys Pro Thr  Pro Cys His Leu Leu  Pro Asn Cys 
    1595                 1600                 1605             


Thr Ser  Cys Leu Asp Ser Lys  Gly Ala Asp Gly Gly  Trp Gln His 
    1610                 1615                 1620             


Cys Val  Trp Ser Ser Ser Leu  Gln Gln Cys Leu Ser  Pro Ser Tyr 
    1625                 1630                 1635             


Leu Pro  Leu Arg Cys Met Ala  Gly Gly Cys Gly Arg  Leu Leu Arg 
    1640                 1645                 1650             


Gly Pro  Glu Ser Cys Ser Leu  Gly Cys Ala Gln Ala  Thr Gln Cys 
    1655                 1660                 1665             


Ala Leu  Cys Leu Arg Arg Pro  His Cys Gly Trp Cys  Ala Trp Gly 
    1670                 1675                 1680             


Gly Gln  Asp Gly Gly Gly Arg  Cys Met Glu Gly Gly  Leu Ser Gly 
    1685                 1690                 1695             


Pro Arg  Asp Gly Leu Thr Cys  Gly Arg Pro Gly Ala  Ser Trp Ala 
    1700                 1705                 1710             


Phe Leu  Ser Cys Pro Pro Glu  Asp Glu Cys Ala Asn  Gly His His 
    1715                 1720                 1725             


Asp Cys  Asn Glu Thr Gln Asn  Cys His Asp Gln Pro  His Gly Tyr 
    1730                 1735                 1740             


Glu Cys  Ser Cys Lys Thr Gly  Tyr Thr Met Asp Asn  Met Thr Gly 
    1745                 1750                 1755             


Leu Cys  Arg Pro Val Cys Ala  Gln Gly Cys Val Asn  Gly Ser Cys 
    1760                 1765                 1770             


Val Glu  Pro Asp His Cys Arg  Cys His Phe Gly Phe  Val Gly Arg 
    1775                 1780                 1785             


Asn Cys  Ser Thr Glu Cys Arg  Cys Asn Arg His Ser  Glu Cys Ala 
    1790                 1795                 1800             


Gly Val  Gly Ala Arg Asp His  Cys Leu Leu Cys Arg  Asn His Thr 
    1805                 1810                 1815             


Lys Gly  Ser His Cys Glu Gln  Cys Leu Pro Leu Phe  Val Gly Ser 
    1820                 1825                 1830             


Ala Val  Gly Gly Gly Thr Cys  Arg Pro Cys His Ala  Phe Cys Arg 
    1835                 1840                 1845             


Gly Asn  Ser His Ile Cys Ile  Ser Arg Lys Glu Leu  Gln Met Ser 
    1850                 1855                 1860             


Lys Gly  Glu Pro Lys Lys Tyr  Ser Leu Asp Pro Glu  Glu Ile Glu 
    1865                 1870                 1875             


Asn Trp  Val Thr Glu Gly Pro  Ser Glu Asp Glu Ala  Val Cys Val 
    1880                 1885                 1890             


Asn Cys  Gln Asn Asn Ser Tyr  Gly Glu Lys Cys Glu  Ser Cys Leu 
    1895                 1900                 1905             


Gln Gly  Tyr Phe Leu Leu Asp  Gly Lys Cys Thr Lys  Cys Gln Cys 
    1910                 1915                 1920             


Asn Gly  His Ala Asp Thr Cys  Asn Glu Gln Asp Gly  Thr Gly Cys 
    1925                 1930                 1935             


Pro Cys  Gln Asn Asn Thr Glu  Thr Gly Thr Cys Gln  Gly Ser Ser 
    1940                 1945                 1950             


Pro Ser  Asp Arg Arg Asp Cys  Tyr Lys Tyr Gln Cys  Ala Lys Cys 
    1955                 1960                 1965             


Arg Glu  Ser Phe His Gly Ser  Pro Leu Gly Gly Gln  Gln Cys Tyr 
    1970                 1975                 1980             


Arg Leu  Ile Ser Val Glu Gln  Glu Cys Cys Leu Asp  Pro Thr Ser 
    1985                 1990                 1995             


Gln Thr  Asn Cys Phe His Glu  Pro Lys Arg Arg Ala  Leu Gly Pro 
    2000                 2005                 2010             


Gly Arg  Thr Val Leu Phe Gly  Val Gln Pro Lys Phe  Thr Asn Val 
    2015                 2020                 2025             


Asp Ile  Arg Leu Thr Leu Asp  Val Thr Phe Gly Ala  Val Asp Leu 
    2030                 2035                 2040             


Tyr Val  Ser Thr Ser Tyr Asp  Thr Phe Val Val Arg  Val Ala Pro 
    2045                 2050                 2055             


Asp Thr  Gly Val His Thr Val  His Ile Gln Pro Pro  Pro Ala Pro 
    2060                 2065                 2070             


Pro Pro  Pro Pro Pro Pro Ala  Asp Gly Gly Pro Arg  Gly Ala Gly 
    2075                 2080                 2085             


Asp Pro  Gly Gly Ala Gly Ala  Ser Ser Gly Pro Gly  Ala Pro Ala 
    2090                 2095                 2100             


Glu Pro  Arg Val Arg Glu Val  Trp Pro Arg Gly Leu  Ile Thr Tyr 
    2105                 2110                 2115             


Val Thr  Val Thr Glu Pro Ser  Ala Val Leu Val Val  Arg Gly Val 
    2120                 2125                 2130             


Arg Asp  Arg Leu Val Ile Thr  Tyr Pro His Glu His  His Ala Leu 
    2135                 2140                 2145             


Lys Ser  Ser Arg Phe Tyr Leu  Leu Leu Leu Gly Val  Gly Asp Pro 
    2150                 2155                 2160             


Ser Gly  Pro Gly Ala Asn Gly  Ser Ala Asp Ser Gln  Gly Leu Leu 
    2165                 2170                 2175             


Phe Phe  Arg Gln Asp Gln Ala  His Ile Asp Leu Phe  Val Phe Phe 
    2180                 2185                 2190             


Ser Val  Phe Phe Ser Cys Phe  Phe Leu Phe Leu Ser  Leu Cys Val 
    2195                 2200                 2205             


Leu Leu  Trp Lys Ala Lys Gln  Ala Leu Asp Gln Arg  Gln Glu Gln 
    2210                 2215                 2220             


Arg Arg  His Leu Gln Glu Met  Thr Lys Met Ala Ser  Arg Pro Phe 
    2225                 2230                 2235             


Ala Lys  Val Thr Val Cys Phe  Pro Pro Asp Pro Thr  Ala Pro Ala 
    2240                 2245                 2250             


Ser Ala  Trp Lys Pro Ala Gly  Leu Pro Pro Pro Ala  Phe Arg Arg 
    2255                 2260                 2265             


Ser Glu  Pro Phe Leu Ala Pro  Leu Leu Leu Thr Gly  Ala Gly Gly 
    2270                 2275                 2280             


Pro Trp  Gly Pro Met Gly Gly  Gly Cys Cys Pro Pro  Ala Ile Pro 
    2285                 2290                 2295             


Ala Thr  Thr Ala Gly Leu Arg  Ala Gly Pro Ile Thr  Leu Glu Pro 
    2300                 2305                 2310             


Thr Glu  Asp Gly Met Ala Gly  Val Ala Thr Leu Leu  Leu Gln Leu 
    2315                 2320                 2325             


Pro Gly  Gly Pro His Ala Pro  Asn Gly Ala Cys Leu  Gly Ser Ala 
    2330                 2335                 2340             


Leu Val  Thr Leu Arg His Arg  Leu His Glu Tyr Cys  Gly Gly Gly 
    2345                 2350                 2355             


Gly Gly  Ala Gly Gly Ser Gly  His Gly Thr Gly Ala  Gly Arg Lys 
    2360                 2365                 2370             


Gly Leu  Leu Ser Gln Asp Asn  Leu Thr Ser Met Ser  Leu 
    2375                 2380                 2385     


<210>  44
<211>  10966
<212>  DNA
<213>  Homo sapiens

<400>  44
ggccgctctg gcccaagcgt cccctcgtct ctctgatctg gcccatccgg cttcggaggg     60

aggcgagggt gggtgagcaa agggattggg tctgtggggt ccaggcccga acccctgaag    120

acgggctccg cccccggcac ccgctcgcgc cccgcccccg gctggaggag tctctcctgg    180

accatccgaa cctagcctgt cccggcccgc agcctctatg gaggctcctg ccgggccgta    240

gagcccttcg ccccctgggg acccacccgt ctataaggtc cgtttggcct gcagcagcct    300

gagtccgtaa tgctgggcac tgttcatggg atcggccccc tatggagccc tgtgtctata    360

ggggactcct acggtcccta gggttcggcc ccgtccataa tgactccata tacagggcct    420

tccatcgctc tatagggctc agccctcggc ttccagagcc tgtcagcagt ggccgtaccc    480

ttcgccggga ctgccgggtc tccgggacct cttcgatcta caaggtcatg ttatgcctat    540

agaggtcgca tttgcagggc ctcaccccgg gtagagggtc ctctccaggt ttttacggcc    600

tgtccccgct ctaagggtca gtgcaggagg cggcgatggc cctgggcaag gttctggcca    660

tggcactggt tttggccttg gccgtgctgg ggtcgctgtc ccctggggcc cgggcggggg    720

actgcaaggg gcagcggcag gtgctgcggg aggcgccagg cttcgtgacg gatggtgcgg    780

gcaactacag cgtcaatggc aactgcgagt ggctcatcga ggccccaagc ccccagcacc    840

ggatcctgct ggacttcctt ttcctggaca cagagtgcac gtatgactac ctgttcgtgt    900

atgacggtga ctccccgcga gggccgctgc ttgccagtct aagtgggagc acccgacctc    960

cgcccatcga agcttcctca ggcaagatgc tgctgcacct cttcagtgat gccaactaca   1020

acctgctggg ctttaacgcc tcattccgct tctccctgtg cccgggtggc tgccagagcc   1080

acgggcagtg ccagccaccg ggtgtgtgtg cctgcgagcc gggctggggg ggtcctgact   1140

gtggcctgca ggagtgctca gcctactgtg gcagccacgg cacctgcgcc tcgcccctgg   1200

gaccatgccg ctgtgagcct ggcttcttgg gacgtgcctg tgacctgcac ctgtgggaga   1260

accagggggc tgggtggtgg cacaacgtga gtgccaggga ccctgccttc tctgcccgta   1320

ttggggcagc tggcgccttc ctgtccccac cagggctgct ggcagttttc ggaggccagg   1380

acctcaacaa tgccctgggt gacctcgtcc tatacaactt ctccgccaac acctgggagt   1440

cttgggacct gagtcctgcc ccggctgccc gtcactccca tgtggccgtg gcctgggccg   1500

gctccctggt actgatgggt ggtgagctgg ctgacggctc gctcaccaac gacgtgtggg   1560

ccttcagtcc actgggcagg ggccactggg agctcctggc accacctgcc tccagctcct   1620

cggggccccc aggcctggca ggtcacgcgg ctgccctggt ggatgatgtc tggctatatg   1680

tgtctggagg ccgcaccccg cacgacctct tctcctctgg cctcttccgt ttccgccttg   1740

acagcaccag cgggggctat tgggagcagg tgattccggc aggcggacgg ccccctgctg   1800

ccactggcca ctccatggtg ttccatgccc cctcccgtgc cctgctggtc catggtggac   1860

accggccctc cactgcccgg ttctctgtgc gagtgaactc cactgagctt ttccacgtgg   1920

atcggcatgt gtggacgacg ctgaaggggc gggatgggct tcagggccca agggagcgag   1980

ccttccacac agccagtgtt ctgggcaatt acatggtggt ctatgggggc aatgtgcaca   2040

cccattacca ggaggaaaag tgctacgaag atggcatctt cttctaccac cttggctgcc   2100

atcaatgggt gtcaggagct gagcttgccc cgccaggaac ccctgagggc cgagcagcgc   2160

ctcccagtgg tcggtactca catgtagctg cggtgcttgg tggcagcgtc ctgttggtgg   2220

ctggggggta cagcggccgg ccccgtgggg acttgatggc gtacaaggtg cccccctttg   2280

tgttccaggc acctgcccct gactaccact tggactactg ctccatgtac acagaccaca   2340

gcgtctgctc ccgggacccg gaatgcagtt ggtgccaagg agcctgccaa gctgcacccc   2400

ctcctgggac ccccttgggg gcttgtccag ccgccagctg cctgggcctg ggccgcctcc   2460

tgggtgactg ccaggcctgc ctggccttca gcagccccac agcccctcca cggggacctg   2520

gcaccctggg ctggtgcgtg cacaatgaga gctgcctccc taggcctgag caggcccgct   2580

gccgagggga gcagatctca ggcactgtgg gctggtgggg gcctgcgcct gtcttcgtca   2640

cgtccctgga ggcctgcgtc acccagagct tcctgcctgg cctgcacttg ctcacctttc   2700

agcagccgcc caatacctcc cagcctgaca aggaggaggt ggggcgctgg gtggctcatc   2760

aggagaagga gacgcggcgg ctgcagcgcc ctgggtctgc tcgcctcttc cctctgcctg   2820

ggcgggacca caagtatgca gtagagatcc agggccagct caatggctcg gcaggccctg   2880

ggcacagcga gctaactctg ctgtgggatc ggactggtgt gccaggaggc agcgagatct   2940

ccttcttctt cctggagccc taccgctcgt cgtcctgcac ctcctattct tcctgcctgg   3000

gctgcttggc agaccagggc tgtggctggt gcctgaccag tgccacctgc cacctgcgcc   3060

agggcggagc ccattgcggg gatgacgggg ctggtgggtc cctgctggtg ctggtgccta   3120

ccctctgccc actctgcgag gagcatcggg actgccacgc ctgcacccag gaccccttct   3180

gtgagtggca tcagagcacc agccgcaaag gggacgcggc atgcagccgg cggggccggg   3240

gtcggggtgc cctgaagagt ccagaggagt gtcccccgct ctgcagccag cgactgacct   3300

gtgaggactg cctggccaac tctagccagt gcgcctggtg ccagtccacc cacacctgct   3360

tcctgtttgc tgcctacttg gcccggtacc cacacggggg ctgtcgaggc tgggacgaca   3420

gtgtacactc ggagccacgg tgccggagct gcgatggctt cctgacctgc catgagtgtc   3480

tgcagagcca cgagtgtggc tggtgtggca atgaggacaa ccccacactg ggacggtgcc   3540

tacaggggga cttctcaggg cccctcggtg ggggtaactg ctccctgtgg gtgggggagg   3600

gcctggggct tcccgtggcc ctccctgccc gctgggcata cgcccgctgt cctgacgtgg   3660

atgagtgtcg cctgggcctg gcccggtgcc acccgcgggc gacctgcctg aacacgcccc   3720

tcagctacga gtgtcactgc cagcggggct accagggtga tggcatctca cactgcaacc   3780

gcacgtgctt ggaggactgt ggccatggtg tgtgcagtgg ccccccggac tttacctgcg   3840

tgtgtgacct aggctggaca tcagacctgc cccctcccac acccgccccg ggtccgccag   3900

ccccccgctg ctcccgggac tgtggctgca gcttccacag ccactgccgc aagcggggcc   3960

ctggcttctg cgacgagtgc caggactgga catgggggga gcactgcgaa cgatgccggc   4020

ccggcagctt cggcaacgcc acaggctcta ggggctgccg gccctgccag tgcaacgggc   4080

acggggaccc acgccgtggc cactgcgaca acctcagtgg gctctgcttc tgccaggacc   4140

acaccgaggg tgcccactgc cagctctgct ccccaggcta ttatggggat ccccgggccg   4200

gtggttcctg ctttcgggag tgtgggggtc gcgccctcct caccaacgtg tcctcagtgg   4260

cactgggctc acgccgggtc ggggggctgc tgcctccagg tggcggggct gcaagagccg   4320

ggcctggcct gtcctactgt gtgtgggttg tctcggccac tgaggagcta cagccctgtg   4380

ctcccgggac cctctgtccc ccactcaccc tcaccttctc ccccgacagc agcaccccct   4440

gcacgctgag ctacgtcctg gcgtttgatg gattcccacg cttcctggac actggtgttg   4500

tccagtcgga ccgcagcctc atagctgcct tctgcggcca gcgacgggac aggcccctca   4560

ctgttcaggc cctgtctggg ctgctcgtgc tgcactggga ggccaatggc tcctcatcct   4620

ggggcttcaa tgcttcggtg ggctctgccc gctgtgggtc agggggcccc gggagctgtc   4680

ccgtccccca ggaatgcgtg ccccaggacg gtgctgcagg tgcggggctc tgccgatgtc   4740

ctcagggctg ggctggccca cactgccgca tggctctgtg tcctgagaac tgcaatgccc   4800

acactggggc aggaacttgt aaccagagcc tgggtgtgtg catctgtgcc gagggcttcg   4860

ggggccccga ctgcgccacc aagctggatg gcgggcagct ggtctgggag accctcatgg   4920

acagccgcct ctcagccgac actgccagcc gcttcctgca ccgcctgggc cacaccatgg   4980

tggatggacc cgatgccacc ttgtggatgt ttgggggcct gggcctgccc caggggctgc   5040

tgggaaacct gtacaggtac tcagtgagtg agcggcggtg gacacagatg ctggcgggag   5100

ccgaggacgg gggcccaggc ccatcgcccc gctccttcca tgcagccgca tatgtgcccg   5160

ctggccgtgg tgccatgtat ctgctggggg gacttaccgc tggaggcgtc acccgtgatt   5220

tctgggtcct caacctcacc accctgcaat ggcggcagga gaaggccccc cagaccgtgg   5280

agctgccagc cgttgctggt cacaccctta ctgcccgccg aggcctgtct ctgctcctgg   5340

tgggcggtta ctccccggaa aatggcttca accagcagct gctggagtac cagctggcaa   5400

ccggcacctg ggtgtcagga gcccagagtg ggacaccccc cacaggtctc tatggtcact   5460

ctgctgtcta ccacgaggcc accgactccc tctacgtgtt tggggggttc cgattccatg   5520

tggagctggc ggccccatcc cccgagctct actccctgca ctgtcctgac cgcacctgga   5580

gtctgctggc cccttctcag ggggcaaagc gagatcgtat gaggaatgtg cgtggctcat   5640

ctcggggtct gggccaagtt cctggggagc agcctgggtc atgggggttc cgggaagtca   5700

ggaagaagat ggctctgtgg gctgctcttg ctggtacagg aggtttcctg gaggaaatct   5760

cacctcacct gaaggagccc cgcccccggc ttttccacgc ctcagccctg ttaggggaca   5820

ccatggtggt tcttgggggg cgctcggacc ctgacgagtt cagcagcgac gttctgctct   5880

accaggtcaa ctgcaatgcc tggcttctgc ccgacctcac ccgctcggcc tctgtggggc   5940

ccccaatgga ggagtctgtg gcccatgctg tggcagcagt cgggagccgc ctgtatatct   6000

ctgggggttt cgggggagtg gccctgggcc gcctgctggc actgaccctg ccccctgacc   6060

cctgccgcct gctgtcctca cctgaagctt gtaaccagtc tggggcctgc acctggtgcc   6120

atggggcctg cttgtccggg gatcaggccc acaggctggg ctgcgggggc tccccctgct   6180

ccccaatgcc tcgctccccg gaggaatgtc gacgtctccg gacctgcagt gagtgcctgg   6240

cccgccatcc tcggaccctg caacctggag atggagaggc gtccaccccc cgctgtaagt   6300

ggtgtaccaa ctgccccgaa ggtgcttgca ttggacgcaa tgggtcctgc acctctgaga   6360

atgactgtcg gatcaaccag cgagaggtct tctgggcagg gaactgctcc gaggctgcgt   6420

gcggggctgc tgactgcgag cagtgcacgc gggagggcaa gtgcatgtgg acgcggcagt   6480

tcaagaggac aggggagacc cgccgcatcc tctccgtgca gcccacctat gactggacgt   6540

gcttcagcca ctctctgctg aatgtgtccc ccatgccggt ggaatcatca cccccactgc   6600

cctgccccac cccttgtcac ctcctaccca actgtacctc ctgcctggac tctaagggag   6660

cagatggggg ctggcagcac tgtgtttgga gcagcagcct gcagcagtgt ctgagccctt   6720

cctacctgcc cctgcgatgt atggccggag gctgtgggcg gctgctccgg ggacctgaga   6780

gctgctccct gggctgtgct caggcaactc agtgcgcctt gtgcctgcgg cgcccccatt   6840

gcggctggtg tgcctggggg ggccaggatg ggggtggccg ctgcatggag ggtggactca   6900

gcggcccccg tgatgggctg acatgtgggc gtccgggggc ctcctgggcc ttcctgtcct   6960

gcccccctga ggacgagtgt gcaaacgggc accacgactg caacgagacg cagaattgcc   7020

acgaccagcc ccacggctat gagtgcagct gcaagaccgg ctataccatg gacaacatga   7080

cagggctgtg ccgccctgtg tgcgcccagg gctgcgtgaa cggctcatgt gtggagcccg   7140

accactgccg ctgccacttt ggctttgtgg gccgcaactg ctccacggaa tgccgctgca   7200

accgccacag tgaatgcgct ggtgttgggg cgcgtgacca ctgcttgctc tgccgcaacc   7260

acaccaaggg cagccactgt gagcagtgcc tcccgctgtt tgtgggttca gctgtcggag   7320

gcgggacctg ccggccctgc cacgcctttt gtcgtggaaa tagccacatc tgcatctcca   7380

ggaaggagtt acaaatgtcc aagggagagc caaagaagta ctcactggac ccagaggaga   7440

ttgaaaactg ggtgacagag ggtcctagtg aagacgaggc cgtgtgcgtg aactgccaga   7500

ataacagcta tggggagaaa tgcgagagct gcctgcaggg ctacttcctc ctggacggga   7560

agtgcaccaa atgccagtgt aatggccacg cggacacatg taacgagcag gatgggacgg   7620

gctgtccatg tcagaataac acagagacgg gcacatgcca gggcagctcc cccagtgacc   7680

gtcgagactg ctacaagtac cagtgcgcca agtgccggga atcatttcac gggagtccgc   7740

tgggcggcca gcagtgctac cgcctcatct cggtggagca ggagtgctgc ctggacccca   7800

cgtcccagac caactgcttc catgagccca aacgccgggc gctaggcccc ggccgcactg   7860

tcctctttgg cgtgcagccc aaattcacca acgtggacat ccgcctgacg ctggacgtga   7920

ccttcggggc cgtggacctc tatgtctcca cctcctatga caccttcgtg gtccgtgtgg   7980

cccctgacac tggcgtccat actgtacaca tccagccacc cccagcccca ccacctccac   8040

caccccctgc agatggtggg ccccgggggg ctggggatcc aggaggagca ggggccagca   8100

gtgggccggg cgccccagca gagccacggg tacgggaggt atggccgcgg ggcctgatta   8160

cctacgtgac ggtgacggag ccgtcggcag tgctggtggt ccgcggcgtg cgggaccggc   8220

tggtcatcac ctacccacac gagcaccatg ccctcaagtc gagccgcttc tacctgctgc   8280

tgctgggcgt gggagaccca agtgggcccg gcgccaacgg ctcagccgac tcgcagggcc   8340

tgctcttctt ccggcaggac caggcccaca ttgacctgtt tgtcttcttc tccgtcttct   8400

tctcctgctt cttcctcttc ctctcactct gtgtgctcct ctggaaggcc aagcaggctc   8460

tggaccagcg gcaggagcag cgccggcact tgcaggagat gaccaagatg gccagccgcc   8520

ccttcgccaa ggtcaccgtc tgcttcccac ctgaccctac tgccccggcc tccgcctgga   8580

agccggctgg gctcccacct cccgccttcc gccgctctga gcccttcctg gcacccctgc   8640

tgctgacagg ggccggtggg ccctggggac ccatgggagg gggctgctgc ccaccagcca   8700

tccccgccac cactgctggg ctgcgagctg ggcccatcac tctcgagccc acagaagatg   8760

gcatggctgg cgtggccaca ctgctgctcc agctgcctgg cgggccccat gcacccaacg   8820

gcgcctgcct ggggtcagcc ctcgtcacac tgcggcacag gctgcacgag tactgtgggg   8880

gtggtggggg tgctgggggc agtgggcatg ggactggtgc gggccggaag ggactgttga   8940

gccaggacaa cctcaccagc atgtccctct gacatgccca gggttctcat ccacagcagc   9000

tgggtcacct gatagggccg ccctggactt ggggtccctc cacctggggg cccctggaca   9060

ctgtctactt ggagaccact ggcccccttc ccccagggtt gcccagatgg ggcctccttt   9120

gttctgcatt cagcagctat ttatcgagta cctactctgt caggcactgt cataggcgtg   9180

gggcaaagca ggaaccaaga gacgaggttc cctgatctca tgggacttag gttctggtga   9240

agggagacaa tcagtgcaca tgcacacacc ccacacgcat acacacatga acacatgcac   9300

atgtgcacac acaagtaaga tggcttcaga gagggagaag cactgtgagg cctccagagg   9360

atgtggcagt gagggacgat ggggtgaagt cagctgggca ttcaaagaag ctagactgag   9420

aacgcctgag aagaaccagc tacgggaaga gctttgggaa gcaaaggcag aggccctggg   9480

gtgggagcag gcttgtttta ttggaaggac cagaaaactg gtaagtgtga cccagatcaa   9540

gtgtgaggag atgaggctgg ggatagtcag gggctggatc acccagggcc ttgtgggccc   9600

cacatagggt tttgggtttt attctcaggg caatgggaag ctgttggatg gtttgatgaa   9660

ggggagtgac aggatccgat gtacctattt aagaatttaa gagggtcggg tgcggtggct   9720

catgcctata atcctagcac tttgagaggc caaggtgggc tgatcacaag gtcaagagtt   9780

cgtgaccagc ctggccaata tggtgaaacc ccatgtctac taaaaataca aaaattagct   9840

gggcatggtg gcacacactt gtagtccgag ctactcggga ggctgaggca gaagaatcgc   9900

ttgaacccag gaggcggagg ttgcagtgag ctcagattgc gtcactgcac tccaacctgg   9960

gtgacagagc gagactccac ctcaaaaaaa aaaaaaaaat ttaagaggtc actcagttgt  10020

gctgtggaga atggaccgga gggacaagag gggcagcagg gatggtgggc tggagtaggg  10080

tgctggcaat gagggagtct ggctcagatg tgggatgtgt atggaagaat ataaatgatg  10140

gtgtggatgt cagggtgagg gaggagacaa aaccacgatg acccctagct ttgtggcctg  10200

aactgtgggt ggctgagggg atcgttaatt gaatggggca gactgaggct tgtgaggaag  10260

atcagagtct ggttcttgac atgagatgcc cttcagacat ctcttcactc aggtccaact  10320

agggatacag aaacactgaa tatttcaaca gcagaaattg aatgggggga ttgatagcgc  10380

tggcgaggga agcagctgga aagagacaga tggcaccctg agacagccca gaggtgaata  10440

ggacccccag gctgcaggga taaagctcag tggtggtgtt acctcaccgg ggaccagggt  10500

cacacagcaa agctggaaca acagaggcgt gttgtggggg agcctcagag gggacaaaac  10560

ctctgcctga gatcccaccc caggtgggca tgggggccac tgaggttggg gatgaaaatg  10620

ccggtaccgt cagtgcacag ccctgttcca gacagtgctg cctggaagat ttctgggctc  10680

tcctgaggcg ccaccccgca cctgagccac ctccttggac tcctgtcctc taccccttga  10740

ggacctccct cccttctacc ctagctgtct tcttgaactt gggactctcc tttcccaaga  10800

cttccatcac tagctcctgg agggactgga ctttgcatct tcccttcgcg tggagcctca  10860

gtgtgagagg ccctagccaa tgcgtgcatg tcagaggtgg tggggaccac atcagaagaa  10920

gaggggggtg atgaaattaa caaataaaaa gtatggggaa aaccca                 10966


<210>  45
<211>  10966
<212>  DNA
<213>  Homo sapiens

<400>  45
ggccgctctg gcccaagcgt cccctcgtct ctctgatctg gcccatccgg cttcggaggg     60

aggcgagggt gggtgagcaa agggattggg tctgtggggt ccaggcccga acccctgaag    120

acgggctccg cccccggcac ccgctcgcgc cccgcccccg gctggaggag tctctcctgg    180

accatccgaa cctagcctgt cccggcccgc agcctctatg gaggctcctg ccgggccgta    240

gagcccttcg ccccctgggg acccacccgt ctataaggtc cgtttggcct gcagcagcct    300

gagtccgtaa tgctgggcac tgttcatggg atcggccccc tatggagccc tgtgtctata    360

ggggactcct acggtcccta gggttcggcc ccgtccataa tgactccata tacagggcct    420

tccatcgctc tatagggctc agccctcggc ttccagagcc tgtcagcagt ggccgtaccc    480

ttcgccggga ctgccgggtc tccgggacct cttcgatcta caaggtcatg ttatgcctat    540

agaggtcgca tttgcagggc ctcaccccgg gtagagggtc ctctccaggt ttttacggcc    600

tgtccccgct ctaagggtca gtgcaggagg cggcgatggc cctgggcaag gttctggcca    660

tggcactggt tttggccttg gccgtgctgg ggtcgctgtc ccctggggcc cgggcggggg    720

actgcaaggg gcagcggcag gtgctgcggg aggcgccagg cttcgtgacg gatggtgcgg    780

gcaactacag cgtcaatggc aactgcgagt ggctcatcga ggccccaagc ccccagcacc    840

ggatcctgct ggacttcctt ttcctggaca cagagtgcac gtatgactac ctgttcgtgt    900

atgacggtga ctccccgcga gggccgctgc ttgccagtct aagtgggagc acccgacctc    960

cgcccatcga agcttcctca ggcaagatgc tgctgcacct cttcagtgat gccaactaca   1020

acctgctggg ctttaacgcc tcattccgct tctccctgtg cccgggtggc tgccagagcc   1080

acgggcagtg ccagccaccg ggtgtgtgtg cctgcgagcc gggctggggg ggtcctgact   1140

gtggcctgca ggagtgctca gcctactgtg gcagccacgg cacctgcgcc tcgcccctgg   1200

gaccatgccg ctgtgagcct ggcttcttgg gacgtgcctg tgacctgcac ctgtgggaga   1260

accagggggc tgggtggtgg cacaacgtga gtgccaggga ccctgccttc tctgcccgta   1320

ttggggcagc tggcgccttc ctgtccccac cagggctgct ggcagttttc ggaggccagg   1380

acctcaacaa tgccctgggt gacctcgtcc tatacaactt ctccgccaac acctgggagt   1440

cttgggacct gagtcctgcc ccggctgccc gtcactccca tgtggccgtg gcctgggccg   1500

gctccctggt actgatgggt ggtgagctgg ctgacggctc gctcaccaac gacgtgtggg   1560

ccttcagtcc actgggcagg ggccactggg agctcctggc accacctgcc tccagctcct   1620

cggggccccc aggcctggca ggtcacgcgg ctgccctggt ggatgatgtc tggctatatg   1680

tgtctggagg ccgcaccccg cacgacctct tctcctctgg cctcttccgt ttccgccttg   1740

acagcaccag cgggggctat tgggagcagg tgattccggc aggcggacgg ccccctgctg   1800

ccactggcca ctccatggtg ttccatgccc cctcccgtgc cctgctggtc catggtggac   1860

accggccctc cactgcccgg ttctctgtgc gagtgaactc cactgagctt ttccacgtgg   1920

atcggcatgt gtggacgacg ctgaaggggc gggatgggct tcagggccca agggagcgag   1980

ccttccacac agccagtgtt ctgggcaatt acatggtggt ctatgggggc aatgtgcaca   2040

cccattacca ggaggaaaag tgctacgaag atggcatctt cttctaccac cttggctgcc   2100

atcaatgggt gtcaggagct gagcttgccc cgccaggaac ccctgagggc cgagcagcgc   2160

ctcccagtgg tcggtactca catgtagctg cggtgcttgg tggcagcgtc ctgttggtgg   2220

ctggggggta cagcggccgg ccccgtgggg acttgatggc gtacaaggtg cccccctttg   2280

tgttccaggc acctgcccct gactaccact tggactactg ctccatgtac acagaccaca   2340

gcgtctgctc ccgggacccg gaatgcagtt ggtgccaagg agcctgccaa gctgcacccc   2400

ctcctgggac ccccttgggg gcttgtccag ccgccagctg cctgggcctg ggccgcctcc   2460

tgggtgactg ccaggcctgc ctggccttca gcagccccac agcccctcca cggggacctg   2520

gcaccctggg ctggtgcgtg cacaatgaga gctgcctccc taggcctgag caggcccgct   2580

gccgagggga gcagatctca ggcactgtgg gctggtgggg gcctgcgcct gtcttcgtca   2640

cgtccctgga ggcctgcgtc acccagagct tcctgcctgg cctgcacttg ctcacctttc   2700

agcagccgcc caatacctcc cagcctgaca aggaggaggt ggggcgctgg gtggctcatc   2760

aggagaagga gacgcggcgg ctgcagcgcc ctgggtctgc tcgcctcttc cctctgcctg   2820

ggcgggacca caagtatgca gtagagatcc agggccagct caatggctcg gcaggccctg   2880

ggcacagcga gctaactctg ctgtgggatc ggactggtgt gccaggaggc agcgagatct   2940

ccttcttctt cctggagccc taccgctcgt cgtcctgcac ctcctattct tcctgcctgg   3000

gctgcttggc agaccagggc tgtggctggt gcctgaccag tgccacctgc cacctgcgcc   3060

agggcggagc ccattgcggg gatgacgggg ctggtgggtc cctgctggtg ctggtgccta   3120

ccctctgccc actctgcgag gagcatcggg actgccacgc ctgcacccag gaccccttct   3180

gtgagtggca tcagagcacc agccgcaaag gggacgcggc atgcagccgg cggggccggg   3240

gtcggggtgc cctgaagagt ccagaggagt gtcccccgct ctgcagccag cgactgacct   3300

gtgaggactg cctggccaac tctagccagt gcgcctggtg ccagtccacc cacacctgct   3360

tcctgtttgc tgcctacttg gcccggtacc cacacggggg ctgtcgaggc tgggacgaca   3420

gtgtacactc ggagccacgg tgccggagct gcgatggctt cctgacctgc catgagtgtc   3480

tgcagagcca cgagtgtggc tggtgtggca atgaggacaa ccccacactg ggacggtgcc   3540

tacaggggga cttctcaggg cccctcggtg ggggtaactg ctccctgtgg gtgggggagg   3600

gcctggggct tcccgtggcc ctccctgccc gctgggcata cgcccgctgt cctgacgtgg   3660

atgagtgtcg cctgggcctg gcccggtgcc acccgcgggc gacctgcctg aacacgcccc   3720

tcagctacga gtgtcactgc cagcggggct accagggtga tggcatctca cactgcaacc   3780

gcacgtgctt ggaggactgt ggccatggtg tgtgcagtgg ccccccggac tttacctgcg   3840

tgtgtgacct aggctggaca tcagacctgc cccctcccac acccgccccg ggtccgccag   3900

ccccccgctg ctcccgggac tgtggctgca gcttccacag ccactgccgc aagcggggcc   3960

ctggcttctg cgacgagtgc caggactgga catgggggga gcactgcgaa cgatgccggc   4020

ccggcagctt cggcaacgcc acaggctcta ggggctgccg gccctgccag tgcaacgggc   4080

acggggaccc acgccgtggc cactgcgaca acctcagtgg gctctgcttc tgccaggacc   4140

acaccgaggg tgcccactgc cagctctgct ccccaggcta ttatggggat ccccgggccg   4200

gtggttcctg ctttcgggag tgtgggggtc gcgccctcct caccaacgtg tcctcagtgg   4260

cactgggctc acgccgggtc ggggggctgc tgcctccagg tggcggggct gcaagagccg   4320

ggcctggcct gtcctactgt gtgtgggttg tctcggccac tgaggagcta cagccctgtg   4380

ctcccgggac cctctgtccc ccactcaccc tcaccttctc ccccgacagc agcaccccct   4440

gcacgctgag ctacgtcctg gcgtttgatg gattcccacg cttcctggac actggtgttg   4500

tccagtcgga ccgcagcctc atagctgcct tctgcggcca gcgacgggac aggcccctca   4560

ctgttcaggc cctgtctggg ctgctcgtgc tgcactggga ggccaatggc tcctcatcct   4620

ggggcttcaa tgcttcggtg ggctctgccc gctgtgggtc agggggcccc gggagctgtc   4680

ccgtccccca ggaatgcgtg ccccaggacg gtgctgcagg tgcggggctc tgccgatgtc   4740

ctcagggctg ggctggccca cactgccgca tggctctgtg tcctgagaac tgcaatgccc   4800

acactggggc aggaacttgt aaccagagcc tgggtgtgtg catctgtgcc gagggcttcg   4860

ggggccccga ctgcgccacc aagctggatg gcgggcagct ggtctgggag accctcatgg   4920

acagccgcct ctcagccgac actgccagcc gcttcctgca ccgcctgggc cacaccatgg   4980

tggatggacc cgatgccacc ttgtggatgt ttgggggcct gggcctgccc caggggctgc   5040

tgggaaacct gtacaggtac tcagtgagtg agcggcggtg gacacagatg ctggcgggag   5100

ccgaggacgg gggcccaggc ccatcgcccc gctccttcca tgcagccgca tatgtgcccg   5160

ctggccgtgg tgccatgtat ctgctggggg gacttaccgc tggaggcgtc acccgtgatt   5220

tctgggtcct caacctcacc accctgcaat ggcggcagga gaaggccccc cagaccgtgg   5280

agctgccagc cgttgctggt cacaccctta ctgcccgccg aggcctgtct ctgctcctgg   5340

tgggcggtta ctccccggaa aatggcttca accagcagct gctggagtac cagctggcaa   5400

ccggcacctg ggtgtcagga gcccagagtg ggacaccccc cacaggtctc tatggtcact   5460

ctgctgtcta ccacgaggcc accgactccc tctacgtgtt tggggggttc cgattccatg   5520

tggagctggc ggccccatcc cccgagctct actccctgca ctgtcctgac cgcacctgga   5580

gtctgctggc cccttctcag ggggcaaagc gagatcgtat gaggaatgtg cgtggctcat   5640

ctcggggtct gggccaagtt cctggggagc agcctgggtc atgggggttc cgggaagtca   5700

ggaagaagat ggctctgtgg gctgctcttg ctggtacagg aggtttcctg gaggaaatct   5760

cacctcacct gaaggagccc cgcccccggc ttttccacgc ctcagccctg ttaggggaca   5820

ccatggtggt tcttgggggg cgctcggacc ctgacgagtt cagcagcgac gttctgctct   5880

accaggtcaa ctgcaatgcc tggcttctgc ccgacctcac ccgctcggcc tctgtggggc   5940

ccccaatgga ggagtctgtg gcccatgctg tggcagcagt cgggagccgc ctgtatatct   6000

ctgggggttt cgggggagtg gccctgggcc gcctgctggc actgaccctg ccccctgacc   6060

cctgccgcct gctgtcctca cctgaagctt gtaaccagtc tggggcctgc acctggtgcc   6120

atggggcctg cttgtccggg gatcaggccc acaggctggg ctgcgggggc tccccctgct   6180

ccccaatgcc tcgctccccg gaggaatgtc gacgtctccg gacctgcagt gagtgcctgg   6240

cccgccatcc tcggaccctg caacctggag atggagaggc gtccaccccc cgctgtaagt   6300

ggtgtaccaa ctgccccgaa ggtgcttgca ttggacgcaa tgggtcctgc acctctgaga   6360

atgactgtcg gatcaaccag cgagaggtct tctgggcagg gaactgctcc gaggctgcgt   6420

gcggggctgc tgactgcgag cagtgcacgc gggagggcaa gtgcatgtgg acgcggcagt   6480

tcaagaggac aggggagacc cgccgcatcc tctccgtgca gcccacctat gactggacgt   6540

gcttcagcca ctctctgctg aatgtgtccc ccatgccggt ggaatcatca cccccactgc   6600

cctgccccac cccttgtcac ctcctaccca actgtacctc ctgcctggac tctaagggag   6660

cagatggggg ctggcagcac tgtgtttgga gcagcagcct gcagcagtgt ctgagccctt   6720

cctacctgcc cctgcgatgt atggccggag gctgtgggcg gctgctccgg ggacctgaga   6780

gctgctccct gggctgtgct caggcaactc agtgcgcctt gtgcctgcgg cgcccccatt   6840

gcggctggtg tgcctggggg ggccaggatg ggggtggccg ctgcatggag ggtggactca   6900

gcggcccccg tgatgggctg acatgtgggc gtccgggggc ctcctgggcc ttcctgtcct   6960

gcccccctga ggacgagtgt gcaaacgggc accacgactg caacgagacg cagaattgcc   7020

acgaccagcc ccacggctat gagtgcagct gcaagaccgg ctataccatg gacaacatga   7080

cagggctgtg ccgccctgtg tgcgcccagg gctgcgtgaa cggctcatgt gtggagcccg   7140

accactgccg ctgccacttt ggctttgtgg gccgcaactg ctccacggaa tgccgctgca   7200

accgccacag tgaatgcgct ggtgttgggg cgcgtgacca ctgcttgctc tgccgcaacc   7260

acaccaaggg cagccactgt gagcagtgcc tcccgctgtt tgtgggttca gctgtcggag   7320

gcgggacctg ccggccctgc cacgcctttt gtcgtggaaa tagccacatc tgcatctcca   7380

ggaaggagtt acaaatgtcc aagggagagc caaagaagta ctcactggac ccagaggaga   7440

ttgaaaactg ggtgacagag ggtcctagtg aagacgaggc cgtgtgcgtg aactgccaga   7500

ataacagcta tggggagaaa tgcgagagct gcctgcaggg ctacttcctc ctggacggga   7560

agtgcaccaa atgccagtgt aatggccacg cggacacatg taacgagcag gatgggacgg   7620

gctgtccatg tcagaataac acagagacgg gcacatgcca gggcagctcc cccagtgacc   7680

gtcgagactg ctacaagtac cagtgcgcca agtgccggga atcatttcac gggagtccgc   7740

tgggcggcca gcagtgctac cgcctcatct cggtggagca ggagtgctgc ctggacccca   7800

cgtcccagac caactgcttc catgagccca aacgccgggc gctaggcccc ggccgcactg   7860

tcctctttgg cgtgcagccc aaattcacca acgtggacat ccgcctgacg ctggacgtga   7920

ccttcggggc cgtggacctc tatgtctcca cctcctatga caccttcgtg gtccgtgtgg   7980

cccctgacac tggcgtccat actgtacaca tccagccacc cccagcccca ccacctccac   8040

caccccctgc agatggtggg ccccgggggg ctggggatcc aggaggagca ggggccagca   8100

gtgggccggg cgccccagca gagccacggg tacgggaggt atggccgcgg ggcctgatta   8160

cctacgtgac ggtgacggag ccgtcggcag tgctggtggt ccgcggcgtg cgggaccggc   8220

tggtcatcac ctacccacac gagcaccatg ccctcaagtc gagccgcttc tacctgctgc   8280

tgctgggcgt gggagaccca agtgggcccg gcgccaacgg ctcagccgac tcgcagggcc   8340

tgctcttctt ccggcaggac caggcccaca ttgacctgtt tgtcttcttc tccgtcttct   8400

tctcctgctt cttcctcttc ctctcactct gtgtgctcct ctggaaggcc aagcaggctc   8460

tggaccagcg gcaggagcag cgccggcact tgcaggagat gaccaagatg gccagccgcc   8520

ccttcgccaa ggtcaccgtc tgcttcccac ctgaccctac tgccccggcc tccgcctgga   8580

agccggctgg gctcccacct cccgccttcc gccgctctga gcccttcctg gcacccctgc   8640

tgctgacagg ggccggtggg ccctggggac ccatgggagg gggctgctgc ccaccagcca   8700

tccccgccac cactgctggg ctgcgagctg ggcccatcac tctcgagccc acagaagatg   8760

gcatggctgg cgtggccaca ctgctgctcc agctgcctgg cgggccccat gcacccaacg   8820

gcgcctgcct ggggtcagcc ctcgtcacac tgcggcacag gctgcacgag tactgtgggg   8880

gtggtggggg tgctgggggc agtgggcatg ggactggtgc gggccggaag ggactgttga   8940

gccaggacaa cctcaccagc atgtccctct gacatgccca gggttctcat ccacagcagc   9000

tgggtcacct gatagggccg ccctggactt ggggtccctc cacctggggg cccctggaca   9060

ctgtctactt ggagaccact ggcccccttc ccccagggtt gcccagatgg ggcctccttt   9120

gttctgcatt cagcagctat ttatcgagta cctactctgt caggcactgt cataggcgtg   9180

gggcaaagca ggaaccaaga gacgaggttc cctgatctca tgggacttag gttctggtga   9240

agggagacaa tcagtgcaca tgcacacacc ccacacgcat acacacatga acacatgcac   9300

atgtgcacac acaagtaaga tggcttcaga gagggagaag cactgtgagg cctccagagg   9360

atgtggcagt gagggacgat ggggtgaagt cagctgggca ttcaaagaag ctagactgag   9420

aacgcctgag aagaaccagc tacgggaaga gctttgggaa gcaaaggcag aggccctggg   9480

gtgggagcag gcttgtttta ttggaaggac cagaaaactg gtaagtgtga cccagatcaa   9540

gtgtgaggag atgaggctgg ggatagtcag gggctggatc acccagggcc ttgtgggccc   9600

cacatagggt tttgggtttt attctcaggg caatgggaag ctgttggatg gtttgatgaa   9660

ggggagtgac aggatccgat gtacctattt aagaatttaa gagggtcggg tgcggtggct   9720

catgcctata atcctagcac tttgagaggc caaggtgggc tgatcacaag gtcaagagtt   9780

cgtgaccagc ctggccaata tggtgaaacc ccatgtctac taaaaataca aaaattagct   9840

gggcatggtg gcacacactt gtagtccgag ctactcggga ggctgaggca gaagaatcgc   9900

ttgaacccag gaggcggagg ttgcagtgag ctcagattgc gtcactgcac tccaacctgg   9960

gtgacagagc gagactccac ctcaaaaaaa aaaaaaaaat ttaagaggtc actcagttgt  10020

gctgtggaga atggaccgga gggacaagag gggcagcagg gatggtgggc tggagtaggg  10080

tgctggcaat gagggagtct ggctcagatg tgggatgtgt atggaagaat ataaatgatg  10140

gtgtggatgt cagggtgagg gaggagacaa aaccacgatg acccctagct ttgtggcctg  10200

aactgtgggt ggctgagggg atcgttaatt gaatggggca gactgaggct tgtgaggaag  10260

atcagagtct ggttcttgac atgagatgcc cttcagacat ctcttcactc aggtccaact  10320

agggatacag aaacactgaa tatttcaaca gcagaaattg aatgggggga ttgatagcgc  10380

tggcgaggga agcagctgga aagagacaga tggcaccctg agacagccca gaggtgaata  10440

ggacccccag gctgcaggga taaagctcag tggtggtgtt acctcaccgg ggaccagggt  10500

cacacagcaa agctggaaca acagaggcgt gttgtggggg agcctcagag gggacaaaac  10560

ctctgcctga gatcccaccc caggtgggca tgggggccac tgaggttggg gatgaaaatg  10620

ccggtaccgt cagtgcacag ccctgttcca gacagtgctg cctggaagat ttctgggctc  10680

tcctgaggcg ccaccccgca cctgagccac ctccttggac tcctgtcctc taccccttga  10740

ggacctccct cccttctacc ctagctgtct tcttgaactt gggactctcc tttcccaaga  10800

cttccatcac tagctcctgg agggactgga ctttgcatct tcccttcgcg tggagcctca  10860

gtgtgagagg ccctagccaa tgcgtgcatg tcagaggtgg tggggaccac atcagaagaa  10920

gaggggggtg atgaaattaa caaataaaaa gtatggggaa aaccca                 10966


<210>  46
<211>  11167
<212>  DNA
<213>  Homo sapiens

<400>  46
ggccgctctg gcccaagcgt cccctcgtct ctctgatctg gcccatccgg cttcggaggg     60

aggcgagggt gggtgagcaa agggattggg tctgtggggt ccaggcccga acccctgaag    120

acgggctccg cccccggcac ccgctcgcgc cccgcccccg gctggaggag tctctcctgg    180

accatccgaa cctagcctgt cccggcccgc agcctctatg gaggctcctg ccgggccgta    240

gagcccttcg ccccctgggg acccacccgt ctataaggtc cgtttggcct gcagcagcct    300

gagtccgtaa tgctgggcac tgttcatggg atcggccccc tatggagccc tgtgtctata    360

ggggactcct acggtcccta gggttcggcc ccgtccataa tgactccata tacagggcct    420

tccatcgctc tatagggctc agccctcggc ttccagagcc tgtcagcagt ggccgtaccc    480

ttcgccggga ctgccgggtc tccgggacct cttcgatcta caaggtcatg ttatgcctat    540

agaggtcgca tttgcagggc ctcaccccgg gtagagggtc ctctccaggt ttttacggcc    600

tgtccccgct ctaagggtca gtgcaggagg cggcgatggc cctgggcaag gttctggcca    660

tggcactggt tttggccttg gccgtgctgg ggtcgctgtc ccctggggcc cgggcggggg    720

actgcaaggg gcagcggcag gtgctgcggg aggcgccagg cttcgtgacg gatggtgcgg    780

gcaactacag cgtcaatggc aactgcgagt ggctcatcga ggccccaagc ccccagcacc    840

ggatcctgct ggacttcctt ttcctggaca cagagtgcac gtatgactac ctgttcgtgt    900

atgacggtga ctccccgcga gggccgctgc ttgccagtct aagtgggagc acccgacctc    960

cgcccatcga agcttcctca ggcaagatgc tgctgcacct cttcagtgat gccaactaca   1020

acctgctggg ctttaacgcc tcattccgct tctccctgtg cccgggtggc tgccagagcc   1080

acgggcagtg ccagccaccg ggtgtgtgtg cctgcgagcc gggctggggg ggtcctgact   1140

gtggcctgca ggagtgctca gcctactgtg gcagccacgg cacctgcgcc tcgcccctgg   1200

gaccatgccg ctgtgagcct ggcttcttgg gacgtgcctg tgacctgcac ctgtgggaga   1260

accagggggc tgggtggtgg cacaacgtga gtgccaggga ccctgccttc tctgcccgta   1320

ttggggcagc tggcgccttc ctgtccccac cagggctgct ggcagttttc ggaggccagg   1380

acctcaacaa tgccctgggt gacctcgtcc tatacaactt ctccgccaac acctgggagt   1440

cttgggacct gagtcctgcc ccggctgccc gtcactccca tgtggccgtg gcctgggccg   1500

gctccctggt actgatgggt ggtgagctgg ctgacggctc gctcaccaac gacgtgtggg   1560

ccttcagtcc actgggcagg ggccactggg agctcctggc accacctgcc tccagctcct   1620

cggggccccc aggcctggca ggtcacgcgg ctgccctggt ggatgatgtc tggctatatg   1680

tgtctggagg ccgcaccccg cacgacctct tctcctctgg cctcttccgt ttccgccttg   1740

acagcaccag cgggggctat tgggagcagg tgattccggc aggcggacgg ccccctgctg   1800

ccactggcca ctccatggtg ttccatgccc cctcccgtgc cctgctggtc catggtggac   1860

accggccctc cactgcccgg ttctctgtgc gagtgaactc cactgagctt ttccacgtgg   1920

atcggcatgt gtggacgacg ctgaaggggc gggatgggct tcagggccca agggagcgag   1980

ccttccacac agccagtgtt ctgggcaatt acatggtggt ctatgggggc aatgtgcaca   2040

cccattacca ggaggaaaag tgctacgaag atggcatctt cttctaccac cttggctgcc   2100

atcaatgggt gtcaggagct gagcttgccc cgccaggaac ccctgagggc cgagcagcgc   2160

ctcccagtgg tcggtactca catgtagctg cggtgcttgg tggcagcgtc ctgttggtgg   2220

ctggggggta cagcggccgg ccccgtgggg acttgatggc gtacaaggtg cccccctttg   2280

tgttccaggc acctgcccct gactaccact tggactactg ctccatgtac acagaccaca   2340

gcgtctgctc ccgggacccg gaatgcagtt ggtgccaagg agcctgccaa gctgcacccc   2400

ctcctgggac ccccttgggg gcttgtccag ccgccagctg cctgggcctg ggccgcctcc   2460

tgggtgactg ccaggcctgc ctggccttca gcagccccac agcccctcca cggggacctg   2520

gcaccctggg ctggtgcgtg cacaatgaga gctgcctccc taggcctgag caggcccgct   2580

gccgagggga gcagatctca ggcactgtgg gctggtgggg gcctgcgcct gtcttcgtca   2640

cgtccctgga ggcctgcgtc acccagagct tcctgcctgg cctgcacttg ctcacctttc   2700

agcagccgcc caatacctcc cagcctgaca aggtctcaat tgtccgcagc acgaccatca   2760

ccctaacacc cagcgcagag acagatgtgt ccctggtcta ccgtggcttc atctacccaa   2820

tgctgcctgg agggccaggt ggaccagggg ctgaggacgt ggccgtgtgg acgcgggccc   2880

agcgcctaca cgtcctggcc cggatggccc gtggccctga cacggagaac atggaggagg   2940

tggggcgctg ggtggctcat caggagaagg agacgcggcg gctgcagcgc cctgggtctg   3000

ctcgcctctt ccctctgcct gggcgggacc acaagtatgc agtagagatc cagggccagc   3060

tcaatggctc ggcaggccct gggcacagcg agctaactct gctgtgggat cggactggtg   3120

tgccaggagg cagcgagatc tccttcttct tcctggagcc ctaccgctcg tcgtcctgca   3180

cctcctattc ttcctgcctg ggctgcttgg cagaccaggg ctgtggctgg tgcctgacca   3240

gtgccacctg ccacctgcgc cagggcggag cccattgcgg ggatgacggg gctggtgggt   3300

ccctgctggt gctggtgcct accctctgcc cactctgcga ggagcatcgg gactgccacg   3360

cctgcaccca ggaccccttc tgtgagtggc atcagagcac cagccgcaaa ggggacgcgg   3420

catgcagccg gcggggccgg ggtcggggtg ccctgaagag tccagaggag tgtcccccgc   3480

tctgcagcca gcgactgacc tgtgaggact gcctggccaa ctctagccag tgcgcctggt   3540

gccagtccac ccacacctgc ttcctgtttg ctgcctactt ggcccggtac ccacacgggg   3600

gctgtcgagg ctgggacgac agtgtacact cggagccacg gtgccggagc tgcgatggct   3660

tcctgacctg ccatgagtgt ctgcagagcc acgagtgtgg ctggtgtggc aatgaggaca   3720

accccacact gggacggtgc ctacaggggg acttctcagg gcccctcggt gggggtaact   3780

gctccctgtg ggtgggggag ggcctggggc ttcccgtggc cctccctgcc cgctgggcat   3840

acgcccgctg tcctgacgtg gatgagtgtc gcctgggcct ggcccggtgc cacccgcggg   3900

cgacctgcct gaacacgccc ctcagctacg agtgtcactg ccagcggggc taccagggtg   3960

atggcatctc acactgcaac cgcacgtgct tggaggactg tggccatggt gtgtgcagtg   4020

gccccccgga ctttacctgc gtgtgtgacc taggctggac atcagacctg ccccctccca   4080

cacccgcccc gggtccgcca gccccccgct gctcccggga ctgtggctgc agcttccaca   4140

gccactgccg caagcggggc cctggcttct gcgacgagtg ccaggactgg acatgggggg   4200

agcactgcga acgatgccgg cccggcagct tcggcaacgc cacaggctct aggggctgcc   4260

ggccctgcca gtgcaacggg cacggggacc cacgccgtgg ccactgcgac aacctcagtg   4320

ggctctgctt ctgccaggac cacaccgagg gtgcccactg ccagctctgc tccccaggct   4380

attatgggga tccccgggcc ggtggttcct gctttcggga gtgtgggggt cgcgccctcc   4440

tcaccaacgt gtcctcagtg gcactgggct cacgccgggt cggggggctg ctgcctccag   4500

gtggcggggc tgcaagagcc gggcctggcc tgtcctactg tgtgtgggtt gtctcggcca   4560

ctgaggagct acagccctgt gctcccggga ccctctgtcc cccactcacc ctcaccttct   4620

cccccgacag cagcaccccc tgcacgctga gctacgtcct ggcgtttgat ggattcccac   4680

gcttcctgga cactggtgtt gtccagtcgg accgcagcct catagctgcc ttctgcggcc   4740

agcgacggga caggcccctc actgttcagg ccctgtctgg gctgctcgtg ctgcactggg   4800

aggccaatgg ctcctcatcc tggggcttca atgcttcggt gggctctgcc cgctgtgggt   4860

cagggggccc cgggagctgt cccgtccccc aggaatgcgt gccccaggac ggtgctgcag   4920

gtgcggggct ctgccgatgt cctcagggct gggctggccc acactgccgc atggctctgt   4980

gtcctgagaa ctgcaatgcc cacactgggg caggaacttg taaccagagc ctgggtgtgt   5040

gcatctgtgc cgagggcttc gggggccccg actgcgccac caagctggat ggcgggcagc   5100

tggtctggga gaccctcatg gacagccgcc tctcagccga cactgccagc cgcttcctgc   5160

accgcctggg ccacaccatg gtggatggac ccgatgccac cttgtggatg tttgggggcc   5220

tgggcctgcc ccaggggctg ctgggaaacc tgtacaggta ctcagtgagt gagcggcggt   5280

ggacacagat gctggcggga gccgaggacg ggggcccagg cccatcgccc cgctccttcc   5340

atgcagccgc atatgtgccc gctggccgtg gtgccatgta tctgctgggg ggacttaccg   5400

ctggaggcgt cacccgtgat ttctgggtcc tcaacctcac caccctgcaa tggcggcagg   5460

agaaggcccc ccagaccgtg gagctgccag ccgttgctgg tcacaccctt actgcccgcc   5520

gaggcctgtc tctgctcctg gtgggcggtt actccccgga aaatggcttc aaccagcagc   5580

tgctggagta ccagctggca accggcacct gggtgtcagg agcccagagt gggacacccc   5640

ccacaggtct ctatggtcac tctgctgtct accacgaggc caccgactcc ctctacgtgt   5700

ttggggggtt ccgattccat gtggagctgg cggccccatc ccccgagctc tactccctgc   5760

actgtcctga ccgcacctgg agtctgctgg ccccttctca gggggcaaag cgagatcgta   5820

tgaggaatgt gcgtggctca tctcggggtc tgggccaagt tcctggggag cagcctgggt   5880

catgggggtt ccgggaagtc aggaagaaga tggctctgtg ggctgctctt gctggtacag   5940

gaggtttcct ggaggaaatc tcacctcacc tgaaggagcc ccgcccccgg cttttccacg   6000

cctcagccct gttaggggac accatggtgg ttcttggggg gcgctcggac cctgacgagt   6060

tcagcagcga cgttctgctc taccaggtca actgcaatgc ctggcttctg cccgacctca   6120

cccgctcggc ctctgtgggg cccccaatgg aggagtctgt ggcccatgct gtggcagcag   6180

tcgggagccg cctgtatatc tctgggggtt tcgggggagt ggccctgggc cgcctgctgg   6240

cactgaccct gccccctgac ccctgccgcc tgctgtcctc acctgaagct tgtaaccagt   6300

ctggggcctg cacctggtgc catggggcct gcttgtccgg ggatcaggcc cacaggctgg   6360

gctgcggggg ctccccctgc tccccaatgc ctcgctcccc ggaggaatgt cgacgtctcc   6420

ggacctgcag tgagtgcctg gcccgccatc ctcggaccct gcaacctgga gatggagagg   6480

cgtccacccc ccgctgtaag tggtgtacca actgccccga aggtgcttgc attggacgca   6540

atgggtcctg cacctctgag aatgactgtc ggatcaacca gcgagaggtc ttctgggcag   6600

ggaactgctc cgaggctgcg tgcggggctg ctgactgcga gcagtgcacg cgggagggca   6660

agtgcatgtg gacgcggcag ttcaagagga caggggagac ccgccgcatc ctctccgtgc   6720

agcccaccta tgactggacg tgcttcagcc actctctgct gaatgtgtcc cccatgccgg   6780

tggaatcatc acccccactg ccctgcccca ccccttgtca cctcctaccc aactgtacct   6840

cctgcctgga ctctaaggga gcagatgggg gctggcagca ctgtgtttgg agcagcagcc   6900

tgcagcagtg tctgagccct tcctacctgc ccctgcgatg tatggccgga ggctgtgggc   6960

ggctgctccg gggacctgag agctgctccc tgggctgtgc tcaggcaact cagtgcgcct   7020

tgtgcctgcg gcgcccccat tgcggctggt gtgcctgggg gggccaggat gggggtggcc   7080

gctgcatgga gggtggactc agcggccccc gtgatgggct gacatgtggg cgtccggggg   7140

cctcctgggc cttcctgtcc tgcccccctg aggacgagtg tgcaaacggg caccacgact   7200

gcaacgagac gcagaattgc cacgaccagc cccacggcta tgagtgcagc tgcaagaccg   7260

gctataccat ggacaacatg acagggctgt gccgccctgt gtgcgcccag ggctgcgtga   7320

acggctcatg tgtggagccc gaccactgcc gctgccactt tggctttgtg ggccgcaact   7380

gctccacgga atgccgctgc aaccgccaca gtgaatgcgc tggtgttggg gcgcgtgacc   7440

actgcttgct ctgccgcaac cacaccaagg gcagccactg tgagcagtgc ctcccgctgt   7500

ttgtgggttc agctgtcgga ggcgggacct gccggccctg ccacgccttt tgtcgtggaa   7560

atagccacat ctgcatctcc aggaaggagt tacaaatgtc caagggagag ccaaagaagt   7620

actcactgga cccagaggag attgaaaact gggtgacaga gggtcctagt gaagacgagg   7680

ccgtgtgcgt gaactgccag aataacagct atggggagaa atgcgagagc tgcctgcagg   7740

gctacttcct cctggacggg aagtgcacca aatgccagtg taatggccac gcggacacat   7800

gtaacgagca ggatgggacg ggctgtccat gtcagaataa cacagagacg ggcacatgcc   7860

agggcagctc ccccagtgac cgtcgagact gctacaagta ccagtgcgcc aagtgccggg   7920

aatcatttca cgggagtccg ctgggcggcc agcagtgcta ccgcctcatc tcggtggagc   7980

aggagtgctg cctggacccc acgtcccaga ccaactgctt ccatgagccc aaacgccggg   8040

cgctaggccc cggccgcact gtcctctttg gcgtgcagcc caaattcacc aacgtggaca   8100

tccgcctgac gctggacgtg accttcgggg ccgtggacct ctatgtctcc acctcctatg   8160

acaccttcgt ggtccgtgtg gcccctgaca ctggcgtcca tactgtacac atccagccac   8220

ccccagcccc accacctcca ccaccccctg cagatggtgg gccccggggg gctggggatc   8280

caggaggagc aggggccagc agtgggccgg gcgccccagc agagccacgg gtacgggagg   8340

tatggccgcg gggcctgatt acctacgtga cggtgacgga gccgtcggca gtgctggtgg   8400

tccgcggcgt gcgggaccgg ctggtcatca cctacccaca cgagcaccat gccctcaagt   8460

cgagccgctt ctacctgctg ctgctgggcg tgggagaccc aagtgggccc ggcgccaacg   8520

gctcagccga ctcgcagggc ctgctcttct tccggcagga ccaggcccac attgacctgt   8580

ttgtcttctt ctccgtcttc ttctcctgct tcttcctctt cctctcactc tgtgtgctcc   8640

tctggaaggc caagcaggct ctggaccagc ggcaggagca gcgccggcac ttgcaggaga   8700

tgaccaagat ggccagccgc cccttcgcca aggtcaccgt ctgcttccca cctgacccta   8760

ctgccccggc ctccgcctgg aagccggctg ggctcccacc tcccgccttc cgccgctctg   8820

agcccttcct ggcacccctg ctgctgacag gggccggtgg gccctgggga cccatgggag   8880

ggggctgctg cccaccagcc atccccgcca ccactgctgg gctgcgagct gggcccatca   8940

ctctcgagcc cacagaagat ggcatggctg gcgtggccac actgctgctc cagctgcctg   9000

gcgggcccca tgcacccaac ggcgcctgcc tggggtcagc cctcgtcaca ctgcggcaca   9060

ggctgcacga gtactgtggg ggtggtgggg gtgctggggg cagtgggcat gggactggtg   9120

cgggccggaa gggactgttg agccaggaca acctcaccag catgtccctc tgacatgccc   9180

agggttctca tccacagcag ctgggtcacc tgatagggcc gccctggact tggggtccct   9240

ccacctgggg gcccctggac actgtctact tggagaccac tggccccctt cccccagggt   9300

tgcccagatg gggcctcctt tgttctgcat tcagcagcta tttatcgagt acctactctg   9360

tcaggcactg tcataggcgt ggggcaaagc aggaaccaag agacgaggtt ccctgatctc   9420

atgggactta ggttctggtg aagggagaca atcagtgcac atgcacacac cccacacgca   9480

tacacacatg aacacatgca catgtgcaca cacaagtaag atggcttcag agagggagaa   9540

gcactgtgag gcctccagag gatgtggcag tgagggacga tggggtgaag tcagctgggc   9600

attcaaagaa gctagactga gaacgcctga gaagaaccag ctacgggaag agctttggga   9660

agcaaaggca gaggccctgg ggtgggagca ggcttgtttt attggaagga ccagaaaact   9720

ggtaagtgtg acccagatca agtgtgagga gatgaggctg gggatagtca ggggctggat   9780

cacccagggc cttgtgggcc ccacataggg ttttgggttt tattctcagg gcaatgggaa   9840

gctgttggat ggtttgatga aggggagtga caggatccga tgtacctatt taagaattta   9900

agagggtcgg gtgcggtggc tcatgcctat aatcctagca ctttgagagg ccaaggtggg   9960

ctgatcacaa ggtcaagagt tcgtgaccag cctggccaat atggtgaaac cccatgtcta  10020

ctaaaaatac aaaaattagc tgggcatggt ggcacacact tgtagtccga gctactcggg  10080

aggctgaggc agaagaatcg cttgaaccca ggaggcggag gttgcagtga gctcagattg  10140

cgtcactgca ctccaacctg ggtgacagag cgagactcca cctcaaaaaa aaaaaaaaaa  10200

tttaagaggt cactcagttg tgctgtggag aatggaccgg agggacaaga ggggcagcag  10260

ggatggtggg ctggagtagg gtgctggcaa tgagggagtc tggctcagat gtgggatgtg  10320

tatggaagaa tataaatgat ggtgtggatg tcagggtgag ggaggagaca aaaccacgat  10380

gacccctagc tttgtggcct gaactgtggg tggctgaggg gatcgttaat tgaatggggc  10440

agactgaggc ttgtgaggaa gatcagagtc tggttcttga catgagatgc ccttcagaca  10500

tctcttcact caggtccaac tagggataca gaaacactga atatttcaac agcagaaatt  10560

gaatgggggg attgatagcg ctggcgaggg aagcagctgg aaagagacag atggcaccct  10620

gagacagccc agaggtgaat aggaccccca ggctgcaggg ataaagctca gtggtggtgt  10680

tacctcaccg gggaccaggg tcacacagca aagctggaac aacagaggcg tgttgtgggg  10740

gagcctcaga ggggacaaaa cctctgcctg agatcccacc ccaggtgggc atgggggcca  10800

ctgaggttgg ggatgaaaat gccggtaccg tcagtgcaca gccctgttcc agacagtgct  10860

gcctggaaga tttctgggct ctcctgaggc gccaccccgc acctgagcca cctccttgga  10920

ctcctgtcct ctaccccttg aggacctccc tcccttctac cctagctgtc ttcttgaact  10980

tgggactctc ctttcccaag acttccatca ctagctcctg gagggactgg actttgcatc  11040

ttcccttcgc gtggagcctc agtgtgagag gccctagcca atgcgtgcat gtcagaggtg  11100

gtggggacca catcagaaga agaggggggt gatgaaatta acaaataaaa agtatgggga  11160

aaaccca                                                            11167


<210>  47
<211>  406
<212>  PRT
<213>  Homo sapiens

<400>  47

Met Asp Cys Arg Thr Lys Ala Asn Pro Asp Arg Thr Phe Asp Leu Val 
1               5                   10                  15      


Leu Lys Val Lys Cys His Ala Ser Glu Asn Glu Asp Pro Val Val Leu 
            20                  25                  30          


Trp Lys Phe Pro Glu Asp Phe Gly Asp Gln Glu Ile Leu Gln Ser Val 
        35                  40                  45              


Pro Lys Phe Cys Phe Pro Phe Asp Val Glu Arg Val Ser Gln Asn Gln 
    50                  55                  60                  


Val Gly Gln His Phe Thr Phe Val Leu Thr Asp Ile Glu Ser Lys Gln 
65                  70                  75                  80  


Arg Phe Gly Phe Cys Arg Leu Thr Ser Gly Gly Thr Ile Cys Leu Cys 
                85                  90                  95      


Ile Leu Ser Tyr Leu Pro Trp Phe Glu Val Tyr Tyr Lys Leu Leu Asn 
            100                 105                 110         


Thr Leu Ala Asp Tyr Leu Ala Lys Glu Leu Glu Asn Asp Leu Asn Glu 
        115                 120                 125             


Thr Leu Arg Ser Leu Tyr Asn His Pro Val Pro Lys Ala Asn Thr Pro 
    130                 135                 140                 


Val Asn Leu Ser Val His Ser Tyr Phe Ile Ala Pro Asp Val Thr Gly 
145                 150                 155                 160 


Leu Pro Thr Ile Pro Glu Ser Arg Asn Leu Thr Glu Tyr Phe Val Ala 
                165                 170                 175     


Val Asp Val Asn Asn Met Leu Gln Leu Tyr Ala Ser Met Leu His Glu 
            180                 185                 190         


Arg Arg Ile Val Ile Ile Ser Ser Lys Leu Ser Thr Leu Thr Ala Cys 
        195                 200                 205             


Ile His Gly Ser Ala Ala Leu Leu Tyr Pro Met Tyr Trp Gln His Ile 
    210                 215                 220                 


Tyr Ile Pro Val Leu Pro Pro His Leu Leu Asp Tyr Cys Cys Ala Pro 
225                 230                 235                 240 


Met Pro Tyr Leu Ile Gly Ile His Ser Ser Leu Ile Glu Arg Val Lys 
                245                 250                 255     


Asn Lys Ser Leu Glu Asp Val Val Met Leu Asn Val Asp Thr Asn Thr 
            260                 265                 270         


Leu Glu Ser Pro Phe Ser Asp Leu Asn Asn Leu Pro Ser Asp Val Val 
        275                 280                 285             


Ser Ala Leu Lys Asn Lys Leu Lys Lys Gln Ser Thr Ala Thr Gly Asp 
    290                 295                 300                 


Gly Val Ala Arg Ala Phe Leu Arg Ala Gln Ala Ala Leu Phe Gly Ser 
305                 310                 315                 320 


Tyr Arg Asp Ala Leu Arg Tyr Lys Pro Gly Glu Pro Ile Thr Phe Cys 
                325                 330                 335     


Glu Glu Ser Phe Val Lys His Arg Ser Ser Val Met Lys Gln Phe Leu 
            340                 345                 350         


Glu Thr Ala Ile Asn Leu Gln Leu Phe Lys Gln Phe Ile Asp Gly Arg 
        355                 360                 365             


Leu Ala Lys Leu Asn Ala Gly Arg Gly Phe Ser Asp Val Phe Glu Glu 
    370                 375                 380                 


Glu Ile Thr Ser Gly Gly Phe Cys Gly Gly Lys Asp Lys Leu Gln Tyr 
385                 390                 395                 400 


Asp Tyr Pro Phe Ser Gln 
                405     


<210>  48
<211>  426
<212>  PRT
<213>  Homo sapiens

<400>  48

Met Asp Cys Arg Thr Lys Ala Asn Pro Asp Arg Thr Phe Asp Leu Val 
1               5                   10                  15      


Leu Lys Val Lys Cys His Ala Ser Glu Asn Glu Asp Pro Val Val Leu 
            20                  25                  30          


Trp Lys Phe Pro Glu Asp Phe Gly Asp Gln Glu Ile Leu Gln Ser Val 
        35                  40                  45              


Pro Lys Phe Cys Phe Pro Phe Asp Val Glu Arg Val Ser Gln Asn Gln 
    50                  55                  60                  


Val Gly Gln His Phe Thr Phe Val Leu Thr Asp Ile Glu Ser Lys Gln 
65                  70                  75                  80  


Arg Phe Gly Phe Cys Arg Leu Thr Ser Gly Gly Thr Ile Cys Leu Cys 
                85                  90                  95      


Ile Leu Ser Tyr Leu Pro Trp Phe Glu Val Tyr Tyr Lys Leu Leu Asn 
            100                 105                 110         


Thr Leu Ala Asp Tyr Leu Ala Lys Glu Leu Glu Asn Asp Leu Asn Glu 
        115                 120                 125             


Thr Leu Arg Ser Leu Tyr Asn His Pro Val Pro Lys Ala Asn Thr Pro 
    130                 135                 140                 


Val Asn Leu Ser Val Asn Gln Glu Ile Phe Ile Ala Cys Glu Gln Val 
145                 150                 155                 160 


Leu Lys Asp Gln Pro Ala Leu Val Pro His Ser Tyr Phe Ile Ala Pro 
                165                 170                 175     


Asp Val Thr Gly Leu Pro Thr Ile Pro Glu Ser Arg Asn Leu Thr Glu 
            180                 185                 190         


Tyr Phe Val Ala Val Asp Val Asn Asn Met Leu Gln Leu Tyr Ala Ser 
        195                 200                 205             


Met Leu His Glu Arg Arg Ile Val Ile Ile Ser Ser Lys Leu Ser Thr 
    210                 215                 220                 


Leu Thr Ala Cys Ile His Gly Ser Ala Ala Leu Leu Tyr Pro Met Tyr 
225                 230                 235                 240 


Trp Gln His Ile Tyr Ile Pro Val Leu Pro Pro His Leu Leu Asp Tyr 
                245                 250                 255     


Cys Cys Ala Pro Met Pro Tyr Leu Ile Gly Ile His Ser Ser Leu Ile 
            260                 265                 270         


Glu Arg Val Lys Asn Lys Ser Leu Glu Asp Val Val Met Leu Asn Val 
        275                 280                 285             


Asp Thr Asn Thr Leu Glu Ser Pro Phe Ser Asp Leu Asn Asn Leu Pro 
    290                 295                 300                 


Ser Asp Val Val Ser Ala Leu Lys Asn Lys Leu Lys Lys Gln Ser Thr 
305                 310                 315                 320 


Ala Thr Gly Asp Gly Val Ala Arg Ala Phe Leu Arg Ala Gln Ala Ala 
                325                 330                 335     


Leu Phe Gly Ser Tyr Arg Asp Ala Leu Arg Tyr Lys Pro Gly Glu Pro 
            340                 345                 350         


Ile Thr Phe Cys Glu Glu Ser Phe Val Lys His Arg Ser Ser Val Met 
        355                 360                 365             


Lys Gln Phe Leu Glu Thr Ala Ile Asn Leu Gln Leu Phe Lys Gln Phe 
    370                 375                 380                 


Ile Asp Gly Arg Leu Ala Lys Leu Asn Ala Gly Arg Gly Phe Ser Asp 
385                 390                 395                 400 


Val Phe Glu Glu Glu Ile Thr Ser Gly Gly Phe Cys Gly Gly Lys Asp 
                405                 410                 415     


Lys Leu Gln Tyr Asp Tyr Pro Phe Ser Gln 
            420                 425     


<210>  49
<211>  426
<212>  PRT
<213>  Homo sapiens

<400>  49

Ile Glu Thr Lys Thr Arg Ala Asn Pro Asp Arg Thr Phe Asp Leu Val 
1               5                   10                  15      


Leu Lys Val Lys Cys His Ala Ser Glu Asn Glu Asp Pro Val Val Leu 
            20                  25                  30          


Trp Lys Phe Pro Glu Asp Phe Gly Asp Gln Glu Ile Leu Gln Ser Val 
        35                  40                  45              


Pro Lys Phe Cys Phe Pro Phe Asp Val Glu Arg Val Ser Gln Asn Gln 
    50                  55                  60                  


Val Gly Gln His Phe Thr Phe Val Leu Thr Asp Ile Glu Ser Lys Gln 
65                  70                  75                  80  


Arg Phe Gly Phe Cys Arg Leu Thr Ser Gly Gly Thr Ile Cys Leu Cys 
                85                  90                  95      


Ile Leu Ser Tyr Leu Pro Trp Phe Glu Val Tyr Tyr Lys Leu Leu Asn 
            100                 105                 110         


Thr Leu Ala Asp Tyr Leu Ala Lys Glu Leu Glu Asn Asp Leu Asn Glu 
        115                 120                 125             


Thr Leu Arg Ser Leu Tyr Asn His Pro Val Pro Lys Ala Asn Thr Pro 
    130                 135                 140                 


Val Asn Leu Ser Val Asn Gln Glu Ile Phe Ile Ala Cys Glu Gln Val 
145                 150                 155                 160 


Leu Lys Asp Gln Pro Ala Leu Val Pro His Ser Tyr Phe Ile Ala Pro 
                165                 170                 175     


Asp Val Thr Gly Leu Pro Thr Ile Pro Glu Ser Arg Asn Leu Thr Glu 
            180                 185                 190         


Tyr Phe Val Ala Val Asp Val Asn Asn Met Leu Gln Leu Tyr Ala Ser 
        195                 200                 205             


Met Leu His Glu Arg Arg Ile Val Ile Ile Ser Ser Lys Leu Ser Thr 
    210                 215                 220                 


Leu Thr Ala Cys Ile His Gly Ser Ala Ala Leu Leu Tyr Pro Met Tyr 
225                 230                 235                 240 


Trp Gln His Ile Tyr Ile Pro Val Leu Pro Pro His Leu Leu Asp Tyr 
                245                 250                 255     


Cys Cys Ala Pro Met Pro Tyr Leu Ile Gly Ile His Ser Ser Leu Ile 
            260                 265                 270         


Glu Arg Val Lys Asn Lys Ser Leu Glu Asp Val Val Met Leu Asn Val 
        275                 280                 285             


Asp Thr Asn Thr Leu Glu Ser Pro Phe Ser Asp Leu Asn Asn Leu Pro 
    290                 295                 300                 


Ser Asp Val Val Ser Ala Leu Lys Asn Lys Leu Lys Lys Gln Ser Thr 
305                 310                 315                 320 


Ala Thr Gly Asp Gly Val Ala Arg Ala Phe Leu Arg Ala Gln Ala Ala 
                325                 330                 335     


Leu Phe Gly Ser Tyr Arg Asp Ala Leu Arg Tyr Lys Pro Gly Glu Pro 
            340                 345                 350         


Ile Thr Phe Cys Glu Glu Ser Phe Val Lys His Arg Ser Ser Val Met 
        355                 360                 365             


Lys Gln Phe Leu Glu Thr Ala Ile Asn Leu Gln Leu Phe Lys Gln Phe 
    370                 375                 380                 


Ile Asp Gly Arg Leu Ala Lys Leu Asn Ala Gly Arg Gly Phe Ser Asp 
385                 390                 395                 400 


Val Phe Glu Glu Glu Ile Thr Ser Gly Gly Phe Cys Gly Gly Lys Asp 
                405                 410                 415     


Lys Leu Gln Tyr Asp Tyr Pro Phe Ser Gln 
            420                 425     


<210>  50
<211>  396
<212>  PRT
<213>  Homo sapiens

<400>  50

Met Ala Ala Ala Pro Arg Glu Glu Lys Arg Trp Pro Gln Pro Val Phe 
1               5                   10                  15      


Ser Asn Pro Val Val Leu Trp Lys Phe Pro Glu Asp Phe Gly Asp Gln 
            20                  25                  30          


Glu Ile Leu Gln Ser Val Pro Lys Phe Cys Phe Pro Phe Asp Val Glu 
        35                  40                  45              


Arg Val Ser Gln Asn Gln Val Gly Gln His Phe Thr Phe Val Leu Thr 
    50                  55                  60                  


Asp Ile Glu Ser Lys Gln Arg Phe Gly Phe Cys Arg Leu Thr Ser Gly 
65                  70                  75                  80  


Gly Thr Ile Cys Leu Cys Ile Leu Ser Tyr Leu Pro Trp Phe Glu Val 
                85                  90                  95      


Tyr Tyr Lys Leu Leu Asn Thr Leu Ala Asp Tyr Leu Ala Lys Glu Leu 
            100                 105                 110         


Glu Asn Asp Leu Asn Glu Thr Leu Arg Ser Leu Tyr Asn His Pro Val 
        115                 120                 125             


Pro Lys Ala Asn Thr Pro Val Asn Leu Ser Val His Ser Tyr Phe Ile 
    130                 135                 140                 


Ala Pro Asp Val Thr Gly Leu Pro Thr Ile Pro Glu Ser Arg Asn Leu 
145                 150                 155                 160 


Thr Glu Tyr Phe Val Ala Val Asp Val Asn Asn Met Leu Gln Leu Tyr 
                165                 170                 175     


Ala Ser Met Leu His Glu Arg Arg Ile Val Ile Ile Ser Ser Lys Leu 
            180                 185                 190         


Ser Thr Leu Thr Ala Cys Ile His Gly Ser Ala Ala Leu Leu Tyr Pro 
        195                 200                 205             


Met Tyr Trp Gln His Ile Tyr Ile Pro Val Leu Pro Pro His Leu Leu 
    210                 215                 220                 


Asp Tyr Cys Cys Ala Pro Met Pro Tyr Leu Ile Gly Ile His Ser Ser 
225                 230                 235                 240 


Leu Ile Glu Arg Val Lys Asn Lys Ser Leu Glu Asp Val Val Met Leu 
                245                 250                 255     


Asn Val Asp Thr Asn Thr Leu Glu Ser Pro Phe Ser Asp Leu Asn Asn 
            260                 265                 270         


Leu Pro Ser Asp Val Val Ser Ala Leu Lys Asn Lys Leu Lys Lys Gln 
        275                 280                 285             


Ser Thr Ala Thr Gly Asp Gly Val Ala Arg Ala Phe Leu Arg Ala Gln 
    290                 295                 300                 


Ala Ala Leu Phe Gly Ser Tyr Arg Asp Ala Leu Arg Tyr Lys Pro Gly 
305                 310                 315                 320 


Glu Pro Ile Thr Phe Cys Glu Glu Ser Phe Val Lys His Arg Ser Ser 
                325                 330                 335     


Val Met Lys Gln Phe Leu Glu Thr Ala Ile Asn Leu Gln Leu Phe Lys 
            340                 345                 350         


Gln Phe Ile Asp Gly Arg Leu Ala Lys Leu Asn Ala Gly Arg Gly Phe 
        355                 360                 365             


Ser Asp Val Phe Glu Glu Glu Ile Thr Ser Gly Gly Phe Cys Gly Gly 
    370                 375                 380                 


Lys Asp Lys Leu Gln Tyr Asp Tyr Pro Phe Ser Gln 
385                 390                 395     


<210>  51
<211>  2117
<212>  DNA
<213>  Homo sapiens

<400>  51
gccgggggcg cagccgacat gggcccgccg ccacggctgc tgtgagcagc ctctttccct     60

gtgtggccgc cggcgtgggc ggggacggcg cgaccctcgc gcggccgggc tgcgggcttc    120

caggccagcg cgcgggggcc ggacggacag ccccacaccg acatgtaacc atggactgca    180

ggaccaaggc aaatccagac agaacctttg acttggtgtt gaaagtgaaa tgtcatgcct    240

ctgaaaatga agatcctgtg gtattgtgga aattcccaga ggactttgga gaccaggaaa    300

tactacagag tgtgccaaag ttctgttttc cctttgacgt tgaaagggtg tctcagaatc    360

aagttggaca gcactttacc tttgtactga cagacattga aagtaaacag agatttggat    420

tctgcagact gacgtcagga ggcacaattt gtttatgcat ccttagttac cttccctggt    480

ttgaagtgta ttacaagctt ctaaatactc ttgcagatta cttggctaag gaactggaaa    540

atgatttgaa tgaaactctc agatcactgt ataaccaccc agtaccaaag gcaaatactc    600

ctgtaaattt gagtgtgcat tcctacttca ttgcccctga tgtaactgga ctcccaacaa    660

tacccgagag tagaaatctt acagaatatt ttgttgccgt ggatgtgaac aacatgctgc    720

agctgtatgc cagtatgctg catgaaaggc gcatcgtgat tatctcgagc aaattaagca    780

ctttaactgc ctgtatccat ggatcagctg ctcttctata cccaatgtat tggcaacaca    840

tatacatccc agtgcttcct ccacacctgc tggactactg ctgtgcccca atgccatacc    900

tgattggaat acactccagc ctcatagaga gagtgaaaaa caaatcattg gaagatgttg    960

ttatgttaaa tgttgataca aacacattag aatcaccatt tagtgacttg aacaacctac   1020

caagtgatgt ggtctcggcc ttgaaaaata aactgaagaa gcagtctaca gctacgggtg   1080

atggagtagc tagggccttt cttagagcac aggctgcttt gtttggatcc tacagagatg   1140

cactgagata caaacctggt gagcccatca ctttctgtga ggagagtttt gtaaagcacc   1200

gctcaagcgt gatgaaacag ttcctggaaa ctgccattaa cctccagctt tttaagcagt   1260

ttatcgatgg tcgactggca aaactaaatg caggaagggg tttctctgat gtatttgaag   1320

aagagatcac ttcaggtggc ttttgtggag gtaaagacaa gttacaatat gattatccat   1380

tttctcaata acaattttct tggtctttgc acttgtgtct gataaaacct atttcataaa   1440

caactaatga tttcctccta aatatgtaat gtcttaaata catttttcat cttataaaag   1500

ctatggaatt agcttatttt gcctgatacc tgttactcaa ggcattaagt tggcctcctg   1560

aattggcagc tgttggcctc gataatctct taatattgct ggaaattagt aatacagaaa   1620

tccaatcaac tcatatcttc ctgtctttcc ttctgaatag tagtattctc tgctagaaaa   1680

ctactagtga tggttattac tgagtatgaa tttaagaact gaggttatga ttggtaatac   1740

aatccaaaaa gaagggtctg aacaccaaaa ttctttatac atatttaagt aactgtatta   1800

ttattataca gatgtcttta cctttttgac tttatagatc actgcagcat taagaaagtt   1860

tccagtttac cattccataa gtacaattaa tccttctagt gtaaatgttc aaatactgtt   1920

ataattatct aggcaattaa taatttacaa actgatattt ttgcacgatt gtagtggtgt   1980

atagtcttga cttgcagagc attttgcttg agtccttgaa atgtcgtgtt cattcattat   2040

ttgctgagtg cttacaatgt attaggcact gttctaaata ttaagtgtac taaataaaca   2100

aaaatccttg tattctg                                                  2117


<210>  52
<211>  2177
<212>  DNA
<213>  Homo sapiens

<400>  52
gccgggggcg cagccgacat gggcccgccg ccacggctgc tgtgagcagc ctctttccct     60

gtgtggccgc cggcgtgggc ggggacggcg cgaccctcgc gcggccgggc tgcgggcttc    120

caggccagcg cgcgggggcc ggacggacag ccccacaccg acatgtaacc atggactgca    180

ggaccaaggc aaatccagac agaacctttg acttggtgtt gaaagtgaaa tgtcatgcct    240

ctgaaaatga agatcctgtg gtattgtgga aattcccaga ggactttgga gaccaggaaa    300

tactacagag tgtgccaaag ttctgttttc cctttgacgt tgaaagggtg tctcagaatc    360

aagttggaca gcactttacc tttgtactga cagacattga aagtaaacag agatttggat    420

tctgcagact gacgtcagga ggcacaattt gtttatgcat ccttagttac cttccctggt    480

ttgaagtgta ttacaagctt ctaaatactc ttgcagatta cttggctaag gaactggaaa    540

atgatttgaa tgaaactctc agatcactgt ataaccaccc agtaccaaag gcaaatactc    600

ctgtaaattt gagtgtgaac caagagatat ttattgcctg tgagcaagtt ctgaaagatc    660

agcctgctct agtaccgcat tcctacttca ttgcccctga tgtaactgga ctcccaacaa    720

tacccgagag tagaaatctt acagaatatt ttgttgccgt ggatgtgaac aacatgctgc    780

agctgtatgc cagtatgctg catgaaaggc gcatcgtgat tatctcgagc aaattaagca    840

ctttaactgc ctgtatccat ggatcagctg ctcttctata cccaatgtat tggcaacaca    900

tatacatccc agtgcttcct ccacacctgc tggactactg ctgtgcccca atgccatacc    960

tgattggaat acactccagc ctcatagaga gagtgaaaaa caaatcattg gaagatgttg   1020

ttatgttaaa tgttgataca aacacattag aatcaccatt tagtgacttg aacaacctac   1080

caagtgatgt ggtctcggcc ttgaaaaata aactgaagaa gcagtctaca gctacgggtg   1140

atggagtagc tagggccttt cttagagcac aggctgcttt gtttggatcc tacagagatg   1200

cactgagata caaacctggt gagcccatca ctttctgtga ggagagtttt gtaaagcacc   1260

gctcaagcgt gatgaaacag ttcctggaaa ctgccattaa cctccagctt tttaagcagt   1320

ttatcgatgg tcgactggca aaactaaatg caggaagggg tttctctgat gtatttgaag   1380

aagagatcac ttcaggtggc ttttgtggag gtaaagacaa gttacaatat gattatccat   1440

tttctcaata acaattttct tggtctttgc acttgtgtct gataaaacct atttcataaa   1500

caactaatga tttcctccta aatatgtaat gtcttaaata catttttcat cttataaaag   1560

ctatggaatt agcttatttt gcctgatacc tgttactcaa ggcattaagt tggcctcctg   1620

aattggcagc tgttggcctc gataatctct taatattgct ggaaattagt aatacagaaa   1680

tccaatcaac tcatatcttc ctgtctttcc ttctgaatag tagtattctc tgctagaaaa   1740

ctactagtga tggttattac tgagtatgaa tttaagaact gaggttatga ttggtaatac   1800

aatccaaaaa gaagggtctg aacaccaaaa ttctttatac atatttaagt aactgtatta   1860

ttattataca gatgtcttta cctttttgac tttatagatc actgcagcat taagaaagtt   1920

tccagtttac cattccataa gtacaattaa tccttctagt gtaaatgttc aaatactgtt   1980

ataattatct aggcaattaa taatttacaa actgatattt ttgcacgatt gtagtggtgt   2040

atagtcttga cttgcagagc attttgcttg agtccttgaa atgtcgtgtt cattcattat   2100

ttgctgagtg cttacaatgt attaggcact gttctaaata ttaagtgtac taaataaaca   2160

aaaatccttg tattctg                                                  2177


<210>  53
<211>  2007
<212>  DNA
<213>  Homo sapiens

<400>  53
attgagacaa aaacaagggc aaatccagac agaacctttg acttggtgtt gaaagtgaaa     60

tgtcatgcct ctgaaaatga agatcctgtg gtattgtgga aattcccaga ggactttgga    120

gaccaggaaa tactacagag tgtgccaaag ttctgttttc cctttgacgt tgaaagggtg    180

tctcagaatc aagttggaca gcactttacc tttgtactga cagacattga aagtaaacag    240

agatttggat tctgcagact gacgtcagga ggcacaattt gtttatgcat ccttagttac    300

cttccctggt ttgaagtgta ttacaagctt ctaaatactc ttgcagatta cttggctaag    360

gaactggaaa atgatttgaa tgaaactctc agatcactgt ataaccaccc agtaccaaag    420

gcaaatactc ctgtaaattt gagtgtgaac caagagatat ttattgcctg tgagcaagtt    480

ctgaaagatc agcctgctct agtaccgcat tcctacttca ttgcccctga tgtaactgga    540

ctcccaacaa tacccgagag tagaaatctt acagaatatt ttgttgccgt ggatgtgaac    600

aacatgctgc agctgtatgc cagtatgctg catgaaaggc gcatcgtgat tatctcgagc    660

aaattaagca ctttaactgc ctgtatccat ggatcagctg ctcttctata cccaatgtat    720

tggcaacaca tatacatccc agtgcttcct ccacacctgc tggactactg ctgtgcccca    780

atgccatacc tgattggaat acactccagc ctcatagaga gagtgaaaaa caaatcattg    840

gaagatgttg ttatgttaaa tgttgataca aacacattag aatcaccatt tagtgacttg    900

aacaacctac caagtgatgt ggtctcggcc ttgaaaaata aactgaagaa gcagtctaca    960

gctacgggtg atggagtagc tagggccttt cttagagcac aggctgcttt gtttggatcc   1020

tacagagatg cactgagata caaacctggt gagcccatca ctttctgtga ggagagtttt   1080

gtaaagcacc gctcaagcgt gatgaaacag ttcctggaaa ctgccattaa cctccagctt   1140

tttaagcagt ttatcgatgg tcgactggca aaactaaatg caggaagggg tttctctgat   1200

gtatttgaag aagagatcac ttcaggtggc ttttgtggag gtaaagacaa gttacaatat   1260

gattatccat tttctcaata acaattttct tggtctttgc acttgtgtct gataaaacct   1320

atttcataaa caactaatga tttcctccta aatatgtaat gtcttaaata catttttcat   1380

cttataaaag ctatggaatt agcttatttt gcctgatacc tgttactcaa ggcattaagt   1440

tggcctcctg aattggcagc tgttggcctc gataatctct taatattgct ggaaattagt   1500

aatacagaaa tccaatcaac tcatatcttc ctgtctttcc ttctgaatag tagtattctc   1560

tgctagaaaa ctactagtga tggttattac tgagtatgaa tttaagaact gaggttatga   1620

ttggtaatac aatccaaaaa gaagggtctg aacaccaaaa ttctttatac atatttaagt   1680

aactgtatta ttattataca gatgtcttta cctttttgac tttatagatc actgcagcat   1740

taagaaagtt tccagtttac cattccataa gtacaattaa tccttctagt gtaaatgttc   1800

aaatactgtt ataattatct aggcaattaa taatttacaa actgatattt ttgcacgatt   1860

gtagtggtgt atagtcttga cttgcagagc attttgcttg agtccttgaa atgtcgtgtt   1920

cattcattat ttgctgagtg cttacaatgt attaggcact gttctaaata ttaagtgtac   1980

taaataaaca aaaatccttg tattctg                                       2007


<210>  54
<211>  2197
<212>  DNA
<213>  Homo sapiens

<400>  54
gcgggggccg gacggacagc cccacaccga catgtaacca tggactgcag gaccaaggca     60

aatccagaca gaacctttga cttggtgttg aaagtgaaat gtcatgcctc tgaaaatgaa    120

gaggacagtc cagcttatct gccgaggatt ccccctggaa aagtacgccg attcgcattt    180

tgcattaaga aactggaaaa ctttcctgtc ggtcctggcg tagcgcctcc cgtgtccggg    240

gtagaccttg taccggctga aaccgcatag ctcgaccttc atggcggcag ctccacggga    300

ggagaaaaga tggccccaac ctgtattttc gaatcctgtg gtattgtgga aattcccaga    360

ggactttgga gaccaggaaa tactacagag tgtgccaaag ttctgttttc cctttgacgt    420

tgaaagggtg tctcagaatc aagttggaca gcactttacc tttgtactga cagacattga    480

aagtaaacag agatttggat tctgcagact gacgtcagga ggcacaattt gtttatgcat    540

ccttagttac cttccctggt ttgaagtgta ttacaagctt ctaaatactc ttgcagatta    600

cttggctaag gaactggaaa atgatttgaa tgaaactctc agatcactgt ataaccaccc    660

agtaccaaag gcaaatactc ctgtaaattt gagtgtgcat tcctacttca ttgcccctga    720

tgtaactgga ctcccaacaa tacccgagag tagaaatctt acagaatatt ttgttgccgt    780

ggatgtgaac aacatgctgc agctgtatgc cagtatgctg catgaaaggc gcatcgtgat    840

tatctcgagc aaattaagca ctttaactgc ctgtatccat ggatcagctg ctcttctata    900

cccaatgtat tggcaacaca tatacatccc agtgcttcct ccacacctgc tggactactg    960

ctgtgcccca atgccatacc tgattggaat acactccagc ctcatagaga gagtgaaaaa   1020

caaatcattg gaagatgttg ttatgttaaa tgttgataca aacacattag aatcaccatt   1080

tagtgacttg aacaacctac caagtgatgt ggtctcggcc ttgaaaaata aactgaagaa   1140

gcagtctaca gctacgggtg atggagtagc tagggccttt cttagagcac aggctgcttt   1200

gtttggatcc tacagagatg cactgagata caaacctggt gagcccatca ctttctgtga   1260

ggagagtttt gtaaagcacc gctcaagcgt gatgaaacag ttcctggaaa ctgccattaa   1320

cctccagctt tttaagcagt ttatcgatgg tcgactggca aaactaaatg caggaagggg   1380

tttctctgat gtatttgaag aagagatcac ttcaggtggc ttttgtggag gtaaagacaa   1440

gttacaatat gattatccat tttctcaata acaattttct tggtctttgc acttgtgtct   1500

gataaaacct atttcataaa caactaatga tttcctccta aatatgtaat gtcttaaata   1560

catttttcat cttataaaag ctatggaatt agcttatttt gcctgatacc tgttactcaa   1620

ggcattaagt tggcctcctg aattggcagc tgttggcctc gataatctct taatattgct   1680

ggaaattagt aatacagaaa tccaatcaac tcatatcttc ctgtctttcc ttctgaatag   1740

tagtattctc tgctagaaaa ctactagtga tggttattac tgagtatgaa tttaagaact   1800

gaggttatga ttggtaatac aatccaaaaa gaagggtctg aacaccaaaa ttctttatac   1860

atatttaagt aactgtatta ttattataca gatgtcttta cctttttgac tttatagatc   1920

actgcagcat taagaaagtt tccagtttac cattccataa gtacaattaa tccttctagt   1980

gtaaatgttc aaatactgtt ataattatct aggcaattaa taatttacaa actgatattt   2040

ttgcacgatt gtagtggtgt atagtcttga cttgcagagc attttgcttg agtccttgaa   2100

atgtcgtgtt cattcattat ttgctgagtg cttacaatgt attaggcact gttctaaata   2160

ttaagtgtac taaataaaca aaaatccttg tattctg                            2197


<210>  55
<211>  211
<212>  PRT
<213>  Homo sapiens

<400>  55

Met Gly Pro Gln His Leu Arg Leu Val Gln Leu Phe Cys Leu Leu Gly 
1               5                   10                  15      


Ala Ile Ser Thr Leu Pro Arg Met Ser Cys Gly Ala Gly Cys Tyr Lys 
            20                  25                  30          


Thr Gln Lys Gly Thr Ala Arg Gly Val Val Gly Phe Lys Gly Cys Ser 
        35                  40                  45              


Ser Ser Ser Ser Tyr Pro Ala Gln Ile Ser Tyr Leu Val Ser Pro Pro 
    50                  55                  60                  


Gly Val Ser Ile Ala Ser Tyr Ser Arg Val Cys Arg Ser Tyr Leu Cys 
65                  70                  75                  80  


Asn Asn Leu Thr Asn Leu Glu Pro Phe Val Lys Leu Lys Ala Ser Thr 
                85                  90                  95      


Pro Lys Ser Ile Thr Ser Ala Ser Cys Ser Cys Pro Thr Cys Val Gly 
            100                 105                 110         


Glu His Met Lys Asp Cys Leu Pro Asn Phe Val Thr Thr Asn Ser Cys 
        115                 120                 125             


Pro Leu Ala Ala Ser Thr Cys Tyr Ser Ser Thr Leu Lys Phe Gln Ala 
    130                 135                 140                 


Gly Phe Leu Asn Thr Thr Phe Leu Leu Met Gly Cys Ala Arg Glu His 
145                 150                 155                 160 


Asn Gln Leu Leu Ala Asp Phe His His Ile Gly Ser Ile Lys Val Thr 
                165                 170                 175     


Glu Val Leu Asn Ile Leu Glu Lys Ser Gln Ile Val Gly Ala Ala Ser 
            180                 185                 190         


Ser Arg Gln Asp Pro Ala Trp Gly Val Val Leu Gly Leu Leu Phe Ala 
        195                 200                 205             


Phe Arg Asp 
    210     


<210>  56
<211>  246
<212>  PRT
<213>  Homo sapiens

<400>  56

Met Gly Pro Gln His Leu Arg Leu Val Gln Leu Phe Cys Leu Leu Gly 
1               5                   10                  15      


Ala Ile Ser Thr Leu Pro Arg Ala Gly Ala Leu Leu Cys Tyr Glu Ala 
            20                  25                  30          


Thr Ala Ser Arg Phe Arg Ala Val Ala Phe His Asn Trp Lys Trp Leu 
        35                  40                  45              


Leu Met Arg Asn Met Val Cys Lys Leu Gln Glu Gly Cys Glu Glu Thr 
    50                  55                  60                  


Leu Val Phe Ile Glu Thr Gly Thr Ala Arg Gly Val Val Gly Phe Lys 
65                  70                  75                  80  


Gly Cys Ser Ser Ser Ser Ser Tyr Pro Ala Gln Ile Ser Tyr Leu Val 
                85                  90                  95      


Ser Pro Pro Gly Val Ser Ile Ala Ser Tyr Ser Arg Val Cys Arg Ser 
            100                 105                 110         


Tyr Leu Cys Asn Asn Leu Thr Asn Leu Glu Pro Phe Val Lys Leu Lys 
        115                 120                 125             


Ala Ser Thr Pro Lys Ser Ile Thr Ser Ala Ser Cys Ser Cys Pro Thr 
    130                 135                 140                 


Cys Val Gly Glu His Met Lys Asp Cys Leu Pro Asn Phe Val Thr Thr 
145                 150                 155                 160 


Asn Ser Cys Pro Leu Ala Ala Ser Thr Cys Tyr Ser Ser Thr Leu Lys 
                165                 170                 175     


Phe Gln Ala Gly Phe Leu Asn Thr Thr Phe Leu Leu Met Gly Cys Ala 
            180                 185                 190         


Arg Glu His Asn Gln Leu Leu Ala Asp Phe His His Ile Gly Ser Ile 
        195                 200                 205             


Lys Val Thr Glu Val Leu Asn Ile Leu Glu Lys Ser Gln Ile Val Gly 
    210                 215                 220                 


Ala Ala Ser Ser Arg Gln Asp Pro Ala Trp Gly Val Val Leu Gly Leu 
225                 230                 235                 240 


Leu Phe Ala Phe Arg Asp 
                245     


<210>  57
<211>  705
<212>  DNA
<213>  Homo sapiens

<400>  57
atgggacccc agcatttgag acttgtgcag ctgttctgcc ttctaggggc catctccact     60

ctgcctcgta tgtcctgtgg ggctggatgc tataagaccc agaaagggac tgcaagggga    120

gttgtgggct ttaaaggctg cagctcgtct tcgtcttacc ctgcgcaaat ctcctacctt    180

gtttccccac ccggagtgtc cattgcctcc tacagtcgcg tctgccggtc ttatctctgc    240

aacaacctca ccaatttgga gccttttgtg aaactcaagg ccagcactcc taagtctatc    300

acatctgcgt cctgtagctg cccgacctgt gtgggcgagc acatgaagga ttgcctccca    360

aattttgtca ccactaattc ttgccccttg gctgcttcta cgtgttacag ttccacctta    420

aaatttcagg cagggtttct caataccacc ttcctcctca tggggtgtgc tcgtgaacat    480

aaccagcttt tagcagattt tcatcatatt gggagcatca aagtgactga ggtcctcaac    540

atcttagaga agtctcagat tgttggtgca gcatcctcca ggcaagatcc tgcttggggt    600

gtcgtcttag gcctcctgtt tgccttcagg gactgaccat ctagctgcac ccgacaagca    660

cccagactct ttcacataac aaataaaata gcagagttcc ctttc                    705


<210>  58
<211>  2022
<212>  DNA
<213>  Homo sapiens

<400>  58
ggtctgtgca cgggttgcct cgtttctggc cttcccttgc cttgtacctc gacttcgcgc     60

gtggcttgtt tttgctgagt ggaggcctgc gttttctgtt atgtctcttc cggtgcccca    120

caactcctga gctacccttc ttttatgcgt tctctcccag cgctgtgatt accgggttgc    180

ttaccgggcc ctccttcctc agattgcacc cctttccttg tgtctcttct tgtctttgtg    240

tcggttgtga ttttcctaat ctctgatttt ccttttctct cggacgctct ccctcttcgg    300

acccattttc tcccgtgctt catgccctga tagcctggcc ccttcccggc ttccttcgct    360

accggggacg cctctagttt ttctgaattt ctggctggct ccaccctccg cgttcatctt    420

cctcaagagt tcgcccctct gggggctcct ctgtgtaatc gtcgccttct ctgggtattt    480

ctgtgaactc cgtctcacac catcccgcca tcttctctgc cttggcccct tttctctgta    540

cagccagctc tgtgtccttt tcttctcccc ctctaaaatc gactcctctt ctccctgaga    600

gccccacctt tgtgccccac tcctcatttt cctacgcctc cctctctctg ctggtcctct    660

ctctccctgc aaggttccat tccatcaatt tgtttgtctt ttgtaggggt ggcatcccct    720

ctgactactg ctccatcctt tttttttttt tttttttttt tttgcttgag gatttcactt    780

caatcttttc tggttgcgtc tccacttgta ctcagcttgt taggtccagg tccagttgtt    840

ctgcatctga ggctggcgtg tgctgtcttc tctgattggc ctaatctccc tcacccccgt    900

gagatctgtt gtcagccttc gtttctcttt cctgtgtccc agcttttctg cgggtcttgg    960

cacctttctt ggccacagat ttctgggtta cagagcatgt gtgtctgagg cattgcaggc   1020

agaaaagggt ggccgacgtg acctctagct ggactgctgg gcaggggagc tgtcctagat   1080

aaaattggaa agaaacagtg acccagagac aggtggacaa agaattcggg gactgatggg   1140

aactgagctt gggatccaga ctgaaactga ttccagactg acctctagca cccaggaccc   1200

agacacaggg ccatgggacc ccagcatttg agacttgtgc agctgttctg ccttctaggg   1260

gccatctcca ctctgcctcg ggctggagct cttttgtgct atgaagcaac agcctcaaga   1320

ttcagagctg ttgctttcca taactggaag tggcttctga tgaggaacat ggtgtgtaag   1380

ctgcaagagg gctgcgagga gacgctagtg ttcattgaga cagggactgc aaggggagtt   1440

gtgggcttta aaggctgcag ctcgtcttcg tcttaccctg cgcaaatctc ctaccttgtt   1500

tccccacccg gagtgtccat tgcctcctac agtcgcgtct gccggtctta tctctgcaac   1560

aacctcacca atttggagcc ttttgtgaaa ctcaaggcca gcactcctaa gtctatcaca   1620

tctgcgtcct gtagctgccc gacctgtgtg ggcgagcaca tgaaggattg cctcccaaat   1680

tttgtcacca ctaattcttg ccccttggct gcttctacgt gttacagttc caccttaaaa   1740

tttcaggcag ggtttctcaa taccaccttc ctcctcatgg ggtgtgctcg tgaacataac   1800

cagcttttag cagattttca tcatattggg agcatcaaag tgactgaggt cctcaacatc   1860

ttagagaagt ctcagattgt tggtgcagca tcctccaggc aagatcctgc ttggggtgtc   1920

gtcttaggcc tcctgtttgc cttcagggac tgaccatcta gctgcacccg acaagcaccc   1980

agactctttc acataacaaa taaaatagca gagttccctt tc                      2022


<210>  59
<211>  542
<212>  PRT
<213>  Homo sapiens

<400>  59

Met Ala Gln Glu Ile Asp Leu Ser Ala Leu Lys Glu Leu Glu Arg Glu 
1               5                   10                  15      


Ala Ile Leu Gln Val Leu Tyr Arg Asp Gln Ala Val Gln Asn Thr Glu 
            20                  25                  30          


Glu Glu Arg Thr Arg Lys Leu Lys Thr His Leu Gln His Leu Arg Trp 
        35                  40                  45              


Lys Gly Ala Lys Asn Thr Asp Trp Glu His Lys Glu Lys Cys Cys Ala 
    50                  55                  60                  


Arg Cys Gln Gln Val Leu Gly Phe Leu Leu His Arg Gly Ala Val Cys 
65                  70                  75                  80  


Arg Gly Cys Ser His Arg Val Cys Ala Gln Cys Arg Val Phe Leu Arg 
                85                  90                  95      


Gly Thr His Ala Trp Lys Cys Thr Val Cys Phe Glu Asp Arg Asn Val 
            100                 105                 110         


Lys Ile Lys Thr Gly Glu Trp Phe Tyr Glu Glu Arg Ala Lys Lys Phe 
        115                 120                 125             


Pro Thr Gly Gly Lys His Glu Thr Val Gly Gly Gln Leu Leu Gln Ser 
    130                 135                 140                 


Tyr Gln Lys Leu Ser Lys Ile Ser Val Val Pro Pro Thr Pro Pro Pro 
145                 150                 155                 160 


Val Ser Glu Ser Gln Cys Ser Arg Ser Pro Gly Arg Lys Val Ser Ala 
                165                 170                 175     


Pro Asp Ile Leu Lys Pro Leu Asn Gln Glu Asp Pro Lys Cys Ser Thr 
            180                 185                 190         


Asn Pro Ile Leu Lys Gln Gln Asn Leu Pro Ser Ser Pro Ala Pro Ser 
        195                 200                 205             


Thr Ile Phe Ser Gly Gly Phe Arg His Gly Ser Leu Ile Ser Ile Asp 
    210                 215                 220                 


Ser Thr Cys Thr Glu Met Gly Asn Phe Asp Asn Ala Asn Val Thr Gly 
225                 230                 235                 240 


Glu Ile Glu Phe Ala Ile His Tyr Cys Phe Lys Thr His Ser Leu Glu 
                245                 250                 255     


Ile Cys Ile Lys Ala Cys Lys Asn Leu Ala Tyr Gly Glu Glu Lys Lys 
            260                 265                 270         


Lys Lys Cys Asn Pro Tyr Val Lys Thr Tyr Leu Leu Pro Asp Arg Ser 
        275                 280                 285             


Ser Gln Gly Lys Arg Lys Thr Gly Val Gln Arg Asn Thr Val Asp Pro 
    290                 295                 300                 


Thr Phe Gln Glu Thr Leu Lys Tyr Gln Val Ala Pro Ala Gln Leu Val 
305                 310                 315                 320 


Thr Arg Gln Leu Gln Val Ser Val Trp His Leu Gly Thr Leu Ala Arg 
                325                 330                 335     


Arg Val Phe Leu Gly Glu Val Ile Ile Pro Leu Ala Thr Trp Asp Phe 
            340                 345                 350         


Glu Asp Ser Thr Thr Gln Ser Phe Arg Trp His Pro Leu Arg Ala Lys 
        355                 360                 365             


Ala Glu Lys Tyr Glu Asp Ser Val Pro Gln Ser Asn Gly Glu Leu Thr 
    370                 375                 380                 


Val Arg Ala Lys Leu Val Leu Pro Ser Arg Pro Arg Lys Leu Gln Glu 
385                 390                 395                 400 


Ala Gln Glu Gly Thr Asp Gln Pro Ser Leu His Gly Gln Leu Cys Leu 
                405                 410                 415     


Val Val Leu Gly Ala Lys Asn Leu Pro Val Arg Pro Asp Gly Thr Leu 
            420                 425                 430         


Asn Ser Phe Val Lys Gly Cys Leu Thr Leu Pro Asp Gln Gln Lys Leu 
        435                 440                 445             


Arg Leu Lys Ser Pro Val Leu Arg Lys Gln Ala Cys Pro Gln Trp Lys 
    450                 455                 460                 


His Ser Phe Val Phe Ser Gly Val Thr Pro Ala Gln Leu Arg Gln Ser 
465                 470                 475                 480 


Ser Leu Glu Leu Thr Val Trp Asp Gln Ala Leu Phe Gly Met Asn Asp 
                485                 490                 495     


Arg Leu Leu Gly Gly Thr Arg Leu Gly Ser Lys Gly Asp Thr Ala Val 
            500                 505                 510         


Gly Gly Asp Ala Cys Ser Leu Ser Lys Leu Gln Trp Gln Lys Val Leu 
        515                 520                 525             


Ser Ser Pro Asn Leu Trp Thr Asp Met Thr Leu Val Leu His 
    530                 535                 540         


<210>  60
<211>  610
<212>  PRT
<213>  Homo sapiens

<400>  60

Met Ala Gln Glu Ile Asp Leu Ser Ala Leu Lys Glu Leu Glu Arg Glu 
1               5                   10                  15      


Ala Ile Leu Gln Val Leu Tyr Arg Asp Gln Ala Val Gln Asn Thr Glu 
            20                  25                  30          


Glu Glu Arg Thr Arg Lys Leu Lys Thr His Leu Gln His Leu Arg Trp 
        35                  40                  45              


Lys Gly Ala Lys Asn Thr Asp Trp Glu His Lys Glu Lys Cys Cys Ala 
    50                  55                  60                  


Arg Cys Gln Gln Val Leu Gly Phe Leu Leu His Arg Gly Ala Val Cys 
65                  70                  75                  80  


Arg Gly Cys Ser His Arg Val Cys Ala Gln Cys Arg Val Phe Leu Arg 
                85                  90                  95      


Gly Thr His Ala Trp Lys Cys Thr Val Cys Phe Glu Asp Arg Asn Val 
            100                 105                 110         


Lys Ile Lys Thr Gly Glu Trp Phe Tyr Glu Glu Arg Ala Lys Lys Phe 
        115                 120                 125             


Pro Thr Gly Gly Lys His Glu Thr Val Gly Gly Gln Leu Leu Gln Ser 
    130                 135                 140                 


Tyr Gln Lys Leu Ser Lys Ile Ser Val Val Pro Pro Thr Pro Pro Pro 
145                 150                 155                 160 


Val Ser Glu Ser Gln Cys Ser Arg Ser Pro Gly Arg Leu Gln Glu Phe 
                165                 170                 175     


Gly Gln Phe Arg Gly Phe Asn Lys Ser Val Glu Asn Leu Phe Leu Ser 
            180                 185                 190         


Leu Ala Thr His Val Lys Lys Leu Ser Lys Ser Gln Asn Asp Met Thr 
        195                 200                 205             


Ser Glu Lys His Leu Leu Ala Thr Gly Pro Arg Gln Cys Val Gly Gln 
    210                 215                 220                 


Thr Glu Arg Arg Ser Gln Ser Asp Thr Ala Val Asn Val Thr Thr Arg 
225                 230                 235                 240 


Lys Val Ser Ala Pro Asp Ile Leu Lys Pro Leu Asn Gln Glu Asp Pro 
                245                 250                 255     


Lys Cys Ser Thr Asn Pro Ile Leu Lys Gln Gln Asn Leu Pro Ser Ser 
            260                 265                 270         


Pro Ala Pro Ser Thr Ile Phe Ser Gly Gly Phe Arg His Gly Ser Leu 
        275                 280                 285             


Ile Ser Ile Asp Ser Thr Cys Thr Glu Met Gly Asn Phe Asp Asn Ala 
    290                 295                 300                 


Asn Val Thr Gly Glu Ile Glu Phe Ala Ile His Tyr Cys Phe Lys Thr 
305                 310                 315                 320 


His Ser Leu Glu Ile Cys Ile Lys Ala Cys Lys Asn Leu Ala Tyr Gly 
                325                 330                 335     


Glu Glu Lys Lys Lys Lys Cys Asn Pro Tyr Val Lys Thr Tyr Leu Leu 
            340                 345                 350         


Pro Asp Arg Ser Ser Gln Gly Lys Arg Lys Thr Gly Val Gln Arg Asn 
        355                 360                 365             


Thr Val Asp Pro Thr Phe Gln Glu Thr Leu Lys Tyr Gln Val Ala Pro 
    370                 375                 380                 


Ala Gln Leu Val Thr Arg Gln Leu Gln Val Ser Val Trp His Leu Gly 
385                 390                 395                 400 


Thr Leu Ala Arg Arg Val Phe Leu Gly Glu Val Ile Ile Pro Leu Ala 
                405                 410                 415     


Thr Trp Asp Phe Glu Asp Ser Thr Thr Gln Ser Phe Arg Trp His Pro 
            420                 425                 430         


Leu Arg Ala Lys Ala Glu Lys Tyr Glu Asp Ser Val Pro Gln Ser Asn 
        435                 440                 445             


Gly Glu Leu Thr Val Arg Ala Lys Leu Val Leu Pro Ser Arg Pro Arg 
    450                 455                 460                 


Lys Leu Gln Glu Ala Gln Glu Gly Thr Asp Gln Pro Ser Leu His Gly 
465                 470                 475                 480 


Gln Leu Cys Leu Val Val Leu Gly Ala Lys Asn Leu Pro Val Arg Pro 
                485                 490                 495     


Asp Gly Thr Leu Asn Ser Phe Val Lys Gly Cys Leu Thr Leu Pro Asp 
            500                 505                 510         


Gln Gln Lys Leu Arg Leu Lys Ser Pro Val Leu Arg Lys Gln Ala Cys 
        515                 520                 525             


Pro Gln Trp Lys His Ser Phe Val Phe Ser Gly Val Thr Pro Ala Gln 
    530                 535                 540                 


Leu Arg Gln Ser Ser Leu Glu Leu Thr Val Trp Asp Gln Ala Leu Phe 
545                 550                 555                 560 


Gly Met Asn Asp Arg Leu Leu Gly Gly Thr Arg Leu Gly Ser Lys Gly 
                565                 570                 575     


Asp Thr Ala Val Gly Gly Asp Ala Cys Ser Leu Ser Lys Leu Gln Trp 
            580                 585                 590         


Gln Lys Val Leu Ser Ser Pro Asn Leu Trp Thr Asp Met Thr Leu Val 
        595                 600                 605             


Leu His 
    610 


<210>  61
<211>  542
<212>  PRT
<213>  Homo sapiens

<400>  61

Met Ala Gln Glu Ile Asp Leu Ser Ala Leu Lys Glu Leu Glu Arg Glu 
1               5                   10                  15      


Ala Ile Leu Gln Val Leu Tyr Arg Asp Gln Ala Val Gln Asn Thr Glu 
            20                  25                  30          


Glu Glu Arg Thr Arg Lys Leu Lys Thr His Leu Gln His Leu Arg Trp 
        35                  40                  45              


Lys Gly Ala Lys Asn Thr Asp Trp Glu His Lys Glu Lys Cys Cys Ala 
    50                  55                  60                  


Arg Cys Gln Gln Val Leu Gly Phe Leu Leu His Arg Gly Ala Val Cys 
65                  70                  75                  80  


Arg Gly Cys Ser His Arg Val Cys Ala Gln Cys Arg Val Phe Leu Arg 
                85                  90                  95      


Gly Thr His Ala Trp Lys Cys Thr Val Cys Phe Glu Asp Arg Asn Val 
            100                 105                 110         


Lys Ile Lys Thr Gly Glu Trp Phe Tyr Glu Glu Arg Ala Lys Lys Phe 
        115                 120                 125             


Pro Thr Gly Gly Lys His Glu Thr Val Gly Gly Gln Leu Leu Gln Ser 
    130                 135                 140                 


Tyr Gln Lys Leu Ser Lys Ile Ser Val Val Pro Pro Thr Pro Pro Pro 
145                 150                 155                 160 


Val Ser Glu Ser Gln Cys Ser Arg Ser Pro Gly Arg Lys Val Ser Ala 
                165                 170                 175     


Pro Asp Ile Leu Lys Pro Leu Asn Gln Glu Asp Pro Lys Cys Ser Thr 
            180                 185                 190         


Asn Pro Ile Leu Lys Gln Gln Asn Leu Pro Ser Ser Pro Ala Pro Ser 
        195                 200                 205             


Thr Ile Phe Ser Gly Gly Phe Arg His Gly Ser Leu Ile Ser Ile Asp 
    210                 215                 220                 


Ser Thr Cys Thr Glu Met Gly Asn Phe Asp Asn Ala Asn Val Thr Gly 
225                 230                 235                 240 


Glu Ile Glu Phe Ala Ile His Tyr Cys Phe Lys Thr His Ser Leu Glu 
                245                 250                 255     


Ile Cys Ile Lys Ala Cys Lys Asn Leu Ala Tyr Gly Glu Glu Lys Lys 
            260                 265                 270         


Lys Lys Cys Asn Pro Tyr Val Lys Thr Tyr Leu Leu Pro Asp Arg Ser 
        275                 280                 285             


Ser Gln Gly Lys Arg Lys Thr Gly Val Gln Arg Asn Thr Val Asp Pro 
    290                 295                 300                 


Thr Phe Gln Glu Thr Leu Lys Tyr Gln Val Ala Pro Ala Gln Leu Val 
305                 310                 315                 320 


Thr Arg Gln Leu Gln Val Ser Val Trp His Leu Gly Thr Leu Ala Arg 
                325                 330                 335     


Arg Val Phe Leu Gly Glu Val Ile Ile Pro Leu Ala Thr Trp Asp Phe 
            340                 345                 350         


Glu Asp Ser Thr Thr Gln Ser Phe Arg Trp His Pro Leu Arg Ala Lys 
        355                 360                 365             


Ala Glu Lys Tyr Glu Asp Ser Val Pro Gln Ser Asn Gly Glu Leu Thr 
    370                 375                 380                 


Val Arg Ala Lys Leu Val Leu Pro Ser Arg Pro Arg Lys Leu Gln Glu 
385                 390                 395                 400 


Ala Gln Glu Gly Thr Asp Gln Pro Ser Leu His Gly Gln Leu Cys Leu 
                405                 410                 415     


Val Val Leu Gly Ala Lys Asn Leu Pro Val Arg Pro Asp Gly Thr Leu 
            420                 425                 430         


Asn Ser Phe Val Lys Gly Cys Leu Thr Leu Pro Asp Gln Gln Lys Leu 
        435                 440                 445             


Arg Leu Lys Ser Pro Val Leu Arg Lys Gln Ala Cys Pro Gln Trp Lys 
    450                 455                 460                 


His Ser Phe Val Phe Ser Gly Val Thr Pro Ala Gln Leu Arg Gln Ser 
465                 470                 475                 480 


Ser Leu Glu Leu Thr Val Trp Asp Gln Ala Leu Phe Gly Met Asn Asp 
                485                 490                 495     


Arg Leu Leu Gly Gly Thr Arg Leu Gly Ser Lys Gly Asp Thr Ala Val 
            500                 505                 510         


Gly Gly Asp Ala Cys Ser Leu Ser Lys Leu Gln Trp Gln Lys Val Leu 
        515                 520                 525             


Ser Ser Pro Asn Leu Trp Thr Asp Met Thr Leu Val Leu His 
    530                 535                 540         


<210>  62
<211>  2277
<212>  DNA
<213>  Homo sapiens

<400>  62
aagaagaatt gacttccttc tctgcagagc cggctctggt ctcttctctt gaagcagatg     60

cgaaggctcc ccgaatgaga aagaatactc ggaatcagcg gtgaattgca gtgatctttc    120

agagaaagcg cctgttcaac tttgtcctct ctcagagact cagagccttg gggcactgag    180

ggatgccagt tctgcctgtt catctggaac ctggatctaa ggagggaaga ggcgttgccc    240

ctgctggcat agtcaggtat tgaacgggct gagcttttca tgatggttcc tgctgacctg    300

gaaacatctt aaatggaagg gcgtgagcgc ttggtccatg cagtgaagct cttccaacct    360

gggtcaacga aaacggagaa gaaatggccc aagaaataga tctgagtgct ctcaaggagt    420

tagaacgcga ggccattctc caggtcctgt accgagacca ggcggttcaa aacacagagg    480

aggagaggac acggaaactg aaaacacacc tgcagcatct ccggtggaaa ggagcgaaga    540

acacggactg ggagcacaaa gagaagtgct gtgcgcgctg ccagcaggtg ctggggttcc    600

tgctgcaccg gggcgccgtg tgccggggct gcagccaccg cgtgtgtgcc cagtgccgag    660

tgttcctgag ggggacccat gcctggaagt gcacggtgtg cttcgaggac aggaatgtca    720

aaataaaaac tggagaatgg ttctatgagg aacgagccaa gaaatttcca actggaggca    780

aacatgagac agttggaggg cagctcttgc aatcttatca gaagctgagc aaaatttctg    840

tggttcctcc tactccacct cctgtcagcg agagccagtg cagccgcagt cctggcagga    900

aggtcagtgc accagatatt ctgaaacctc tcaatcaaga ggatcccaaa tgctctacta    960

accctatttt gaagcaacag aatctcccat ccagtccggc acccagtacc atattctctg   1020

gaggttttag acacggaagt ttaattagca ttgacagcac ctgtacagag atgggcaatt   1080

ttgacaatgc taatgtcact ggagaaatag aatttgccat tcattattgc ttcaaaaccc   1140

attctttaga aatatgcatc aaggcctgta agaaccttgc ctatggagaa gaaaagaaga   1200

aaaagtgcaa tccgtatgtg aagacctacc tgttgcccga cagatcctcc cagggaaagc   1260

gcaagactgg agtccaaagg aacaccgtgg acccgacctt tcaggagacc ttgaagtatc   1320

aggtggcccc tgcccagctg gtgacccggc agctgcaggt ctcggtgtgg catctgggca   1380

cgctggcccg gagagtgttt cttggagaag tgatcattcc tctggccacg tgggactttg   1440

aagacagcac aacacagtcc ttccgctggc atccgctccg ggccaaggcg gagaaatacg   1500

aagacagcgt tcctcagagt aatggagagc tcacagtccg ggctaagctg gttctccctt   1560

cacggcccag aaaactccaa gaggctcaag aagggacaga tcagccatca cttcatggtc   1620

aactttgttt ggtagtgcta ggagccaaga atttacctgt gcggccagat ggcaccttga   1680

actcatttgt taagggctgt ctcactctgc cagaccaaca aaaactgaga ctgaagtcgc   1740

cagtcctgag gaagcaggct tgcccccagt ggaaacactc atttgtcttc agtggcgtaa   1800

ccccagctca gctgaggcag tcaagcttgg agttaactgt ctgggatcag gccctctttg   1860

gaatgaacga ccgcttgctt ggaggaacca gacttggttc aaagggagac acagctgttg   1920

gcggggatgc atgctcacta tcgaagctcc agtggcagaa agtcctttcc agccccaatc   1980

tatggacaga catgactctt gtcctgcact gacatgaagg cctcaaggtt ccaggttgca   2040

gcaggcgtga ggcactgtgc gtctgcagag gggctacgaa ccaggtgcag ggtcccagct   2100

ggagacccct ttgaccttga gcagtctcca tctgcggccc tgtcccatgg cttaaccgcc   2160

tattggtatc tgtgtatatt tacgttaaac acaattatgt tacctaagcc tctggtgggt   2220

tatctcctct ttgagatgta gaaaatggcc agattttaat aaacgttgtt acccatg      2277


<210>  63
<211>  2131
<212>  DNA
<213>  Homo sapiens

<400>  63
aggagggaag aggcgttgcc cctgctggca tagtcaggta ccagcccagc caggtattga     60

acgggctgag cttttcatga tggttcctgc tgacctggaa acatcttaaa tggaagggcg    120

tgagcgcttg gtccatgcag tgaagctctt ccaacctggg tcaacgaaaa cggagaagaa    180

atggcccaag aaatagatct gagtgctctc aaggagttag aacgcgaggc cattctccag    240

gtcctgtacc gagaccaggc ggttcaaaac acagaggagg agaggacacg gaaactgaaa    300

acacacctgc agcatctccg gtggaaagga gcgaagaaca cggactggga gcacaaagag    360

aagtgctgtg cgcgctgcca gcaggtgctg gggttcctgc tgcaccgggg cgccgtgtgc    420

cggggctgca gccaccgcgt gtgtgcccag tgccgagtgt tcctgagggg gacccatgcc    480

tggaagtgca cggtgtgctt cgaggacagg aatgtcaaaa taaaaactgg agaatggttc    540

tatgaggaac gagccaagaa atttccaact ggaggcaaac atgagacagt tggagggcag    600

ctcttgcaat cttatcagaa gctgagcaaa atttctgtgg ttcctcctac tccacctcct    660

gtcagcgaga gccagtgcag ccgcagtcct ggcaggttac aggaatttgg tcagtttaga    720

ggatttaata agtccgtgga aaatttgttt ctgtctcttg ctacccacgt gaaaaagctc    780

tccaaatccc agaatgatat gacttctgag aagcatcttc tcgccacggg ccccaggcag    840

tgtgtgggac agacagagag acggagccag tctgacactg cggtcaacgt caccaccagg    900

aaggtcagtg caccagatat tctgaaacct ctcaatcaag aggatcccaa atgctctact    960

aaccctattt tgaagcaaca gaatctccca tccagtccgg cacccagtac catattctct   1020

ggaggtttta gacacggaag tttaattagc attgacagca cctgtacaga gatgggcaat   1080

tttgacaatg ctaatgtcac tggagaaata gaatttgcca ttcattattg cttcaaaacc   1140

cattctttag aaatatgcat caaggcctgt aagaaccttg cctatggaga agaaaagaag   1200

aaaaagtgca atccgtatgt gaagacctac ctgttgcccg acagatcctc ccagggaaag   1260

cgcaagactg gagtccaaag gaacaccgtg gacccgacct ttcaggagac cttgaagtat   1320

caggtggccc ctgcccagct ggtgacccgg cagctgcagg tctcggtgtg gcatctgggc   1380

acgctggccc ggagagtgtt tcttggagaa gtgatcattc ctctggccac gtgggacttt   1440

gaagacagca caacacagtc cttccgctgg catccgctcc gggccaaggc ggagaaatac   1500

gaagacagcg ttcctcagag taatggagag ctcacagtcc gggctaagct ggttctccct   1560

tcacggccca gaaaactcca agaggctcaa gaagggacag atcagccatc acttcatggt   1620

caactttgtt tggtagtgct aggagccaag aatttacctg tgcggccaga tggcaccttg   1680

aactcatttg ttaagggctg tctcactctg ccagaccaac aaaaactgag actgaagtcg   1740

ccagtcctga ggaagcaggc ttgcccccag tggaaacact catttgtctt cagtggcgta   1800

accccagctc agctgaggca gtcaagcttg gagttaactg tctgggatca ggccctcttt   1860

ggaatgaacg accgcttgct tggaggaacc agacttggtt caaagggaga cacagctgtt   1920

ggcggggatg catgctcact atcgaagctc cagtggcaga aagtcctttc cagccccaat   1980

ctatggacag acatgactct tgtcctgcac tgacatgaag gcctcaaggt tccaggttgc   2040

agcaggcgtg aggcactgtg cgtctgcaga ggggctacga accaggtgca gggtcccagc   2100

tggagacccc tttgaccttg agcagtctcc a                                  2131


<210>  64
<211>  1927
<212>  DNA
<213>  Homo sapiens

<400>  64
aggagggaag aggcgttgcc cctgctggca tagtcaggta ccagcccagc caggtattga     60

acgggctgag cttttcatga tggttcctgc tgacctggaa acatcttaaa tggaagggcg    120

tgagcgcttg gtccatgcag tgaagctctt ccaacctggg tcaacgaaaa cggagaagaa    180

atggcccaag aaatagatct gagtgctctc aaggagttag aacgcgaggc cattctccag    240

gtcctgtacc gagaccaggc ggttcaaaac acagaggagg agaggacacg gaaactgaaa    300

acacacctgc agcatctccg gtggaaagga gcgaagaaca cggactggga gcacaaagag    360

aagtgctgtg cgcgctgcca gcaggtgctg gggttcctgc tgcaccgggg cgccgtgtgc    420

cggggctgca gccaccgcgt gtgtgcccag tgccgagtgt tcctgagggg gacccatgcc    480

tggaagtgca cggtgtgctt cgaggacagg aatgtcaaaa taaaaactgg agaatggttc    540

tatgaggaac gagccaagaa atttccaact ggaggcaaac atgagacagt tggagggcag    600

ctcttgcaat cttatcagaa gctgagcaaa atttctgtgg ttcctcctac tccacctcct    660

gtcagcgaga gccagtgcag ccgcagtcct ggcaggaagg tcagtgcacc agatattctg    720

aaacctctca atcaagagga tcccaaatgc tctactaacc ctattttgaa gcaacagaat    780

ctcccatcca gtccggcacc cagtaccata ttctctggag gttttagaca cggaagttta    840

attagcattg acagcacctg tacagagatg ggcaattttg acaatgctaa tgtcactgga    900

gaaatagaat ttgccattca ttattgcttc aaaacccatt ctttagaaat atgcatcaag    960

gcctgtaaga accttgccta tggagaagaa aagaagaaaa agtgcaatcc gtatgtgaag   1020

acctacctgt tgcccgacag atcctcccag ggaaagcgca agactggagt ccaaaggaac   1080

accgtggacc cgacctttca ggagaccttg aagtatcagg tggcccctgc ccagctggtg   1140

acccggcagc tgcaggtctc ggtgtggcat ctgggcacgc tggcccggag agtgtttctt   1200

ggagaagtga tcattcctct ggccacgtgg gactttgaag acagcacaac acagtccttc   1260

cgctggcatc cgctccgggc caaggcggag aaatacgaag acagcgttcc tcagagtaat   1320

ggagagctca cagtccgggc taagctggtt ctcccttcac ggcccagaaa actccaagag   1380

gctcaagaag ggacagatca gccatcactt catggtcaac tttgtttggt agtgctagga   1440

gccaagaatt tacctgtgcg gccagatggc accttgaact catttgttaa gggctgtctc   1500

actctgccag accaacaaaa actgagactg aagtcgccag tcctgaggaa gcaggcttgc   1560

ccccagtgga aacactcatt tgtcttcagt ggcgtaaccc cagctcagct gaggcagtca   1620

agcttggagt taactgtctg ggatcaggcc ctctttggaa tgaacgaccg cttgcttgga   1680

ggaaccagac ttggttcaaa gggagacaca gctgttggcg gggatgcatg ctcactatcg   1740

aagctccagt ggcagaaagt cctttccagc cccaatctat ggacagacat gactcttgtc   1800

ctgcactgac atgaaggcct caaggttcca ggttgcagca ggcgtgaggc actgtgcgtc   1860

tgcagagggg ctacgaacca ggtgcagggt cccagctgga gacccctttg accttgagca   1920

gtctcca                                                             1927


<210>  65
<211>  173
<212>  PRT
<213>  Homo sapiens

<400>  65

Met His Trp Lys Met Leu Leu Leu Leu Leu Leu Tyr Tyr Asn Ala Glu 
1               5                   10                  15      


Ala Ser Met Cys His Arg Trp Ser Arg Ala Val Leu Phe Pro Ala Ala 
            20                  25                  30          


His Arg Pro Lys Arg Ser Ser Ser Leu Pro Leu Asn Pro Val Leu Gln 
        35                  40                  45              


Thr Ser Leu Glu Glu Val Glu Leu Leu Tyr Glu Phe Leu Leu Ala Glu 
    50                  55                  60                  


Leu Glu Ile Ser Pro Asp Leu Gln Ile Ser Ile Lys Asp Glu Glu Leu 
65                  70                  75                  80  


Ala Ser Leu Arg Lys Ala Ser Asp Phe Arg Thr Val Cys Asn Asn Val 
                85                  90                  95      


Ile Pro Lys Ser Ile Pro Asp Ile Arg Arg Leu Ser Ala Ser Leu Ser 
            100                 105                 110         


Ser His Pro Gly Ile Leu Lys Lys Glu Asp Phe Glu Arg Thr Val Leu 
        115                 120                 125             


Thr Leu Ala Tyr Thr Ala Tyr Arg Thr Ala Leu Ser His Gly His Gln 
    130                 135                 140                 


Lys Asp Ile Trp Ala Gln Ser Leu Val Ser Leu Phe Gln Ala Leu Arg 
145                 150                 155                 160 


His Asp Leu Met Arg Ser Ser Gln Pro Gly Val Pro Pro 
                165                 170             


<210>  66
<211>  1645
<212>  DNA
<213>  Homo sapiens

<400>  66
gcaaaaggaa gggagggaag cactccatca tctcactggg aagaacggca cgggcatacc     60

tgcagctact ggggttccac tgggcttgag ggtcgatttt tcaccttttg aaggacaaga    120

tgcattggaa gatgttgctg cttctgctgt tgtattacaa tgctgaggct tctatgtgcc    180

acaggtggag cagggctgtg ctcttccctg ccgcccaccg gccaaagagg tcctcatcac    240

tgccattgaa cccagtcctg cagacctccc tggaggaggt ggagctgctc tacgagttcc    300

tgctggccga acttgagatc agccctgacc tgcagatctc catcaaggac gaggagctgg    360

cctccttgcg gaaggcctca gacttccgca ccgtctgcaa caacgtcatc cccaagagca    420

tcccagacat ccgccggctc agcgccagcc tctccagcca ccctggcatc ctcaagaaag    480

aagactttga aaggacagtg ctgaccctgg cctacacagc ctaccgcaca gccctgtccc    540

acggccatca gaaggacatc tgggcgcagt ccctcgttag cctcttccag gccctgaggc    600

acgacttgat gcgctcctca cagccgggag tacctccctg agagactggc ccacaccagg    660

acctcagagc agggaccagc acagtaatcc agaaagtctt cattctctac tccatttaca    720

gagaccagca acaaaactct taccgctgac acagagcagc agagatcaaa cagtaacccc    780

gatgctcttt tctccttgta gtttcctgga agacacatct gattcatgcc atcatgtgac    840

ctgggctgga agaaagggct ggaatggtca ttcaagacgc ctccatgggc agaatggttt    900

gcctatggca ggcagaattc tgatatgctt caacccagag cagtggccac acactcaaga    960

gtgagaacag gcgtgagcca ccgtgcctgg cccaggatct aaaaactttc taagtttcct   1020

ccatcgttgg catcctcaca gctatctcca atgtcactca agagacatca acagacattt   1080

aactgctgca gacttcattg ctctgtcacc tcaccttgaa tctaacaaat caaagtattt   1140

ctgcaggtcc aatggtctaa aatcaaatgc ttgttaaatg actttttaca acacccctta   1200

ctttcctaat ccatttcaat cttatttttt ttattgtggt aaaaaacaca tcaggtaaaa   1260

tgtaccatct taaccatttt taagcatatg gtacagcagt gttaactcca tgcatgttgt   1320

gaaacagacc cccggaactt tctcatcttg taattctgaa gttctatacc caccgaacaa   1380

ctcctctttt ccccttcccc ctgcctgccc cagctcttgg caccattatt ctgctttctg   1440

tttttgagag tctgactact taagatacct catacaagcg ggatctggct tacatttctt   1500

gagcattgta ttctggaaaa gtgtttcctt cctctgaaaa atgggtagag ttctgaagga   1560

gaactactgg tcttattgta cacttgctgt acctattttt atttaacaaa tattcatcta   1620

tggtataata aagatgtcat gattg                                         1645


<210>  67
<211>  552
<212>  PRT
<213>  Homo sapiens

<400>  67

Met Ala Ala Leu Ala Pro Val Gly Ser Pro Ala Ser Arg Gly Pro Arg 
1               5                   10                  15      


Leu Ala Ala Gly Leu Arg Leu Leu Pro Met Leu Gly Leu Leu Gln Leu 
            20                  25                  30          


Leu Ala Glu Pro Gly Leu Gly Arg Val His His Leu Ala Leu Lys Asp 
        35                  40                  45              


Asp Val Arg His Lys Val His Leu Asn Thr Phe Gly Phe Phe Lys Asp 
    50                  55                  60                  


Gly Tyr Met Val Val Asn Val Ser Ser Leu Ser Leu Asn Glu Pro Glu 
65                  70                  75                  80  


Asp Lys Asp Val Thr Ile Gly Phe Ser Leu Asp Arg Thr Lys Asn Asp 
                85                  90                  95      


Gly Phe Ser Ser Tyr Leu Asp Glu Asp Val Asn Tyr Cys Ile Leu Lys 
            100                 105                 110         


Lys Gln Ser Val Ser Val Thr Leu Leu Ile Leu Asp Ile Ser Arg Ser 
        115                 120                 125             


Glu Val Arg Val Lys Ser Pro Pro Glu Ala Gly Thr Gln Leu Pro Lys 
    130                 135                 140                 


Ile Ile Phe Ser Arg Asp Glu Lys Val Leu Gly Gln Ser Gln Glu Pro 
145                 150                 155                 160 


Asn Val Asn Pro Ala Ser Ala Gly Asn Gln Thr Gln Lys Thr Gln Asp 
                165                 170                 175     


Gly Gly Lys Ser Lys Arg Ser Thr Val Asp Ser Lys Ala Met Gly Glu 
            180                 185                 190         


Lys Ser Phe Ser Val His Asn Asn Gly Gly Ala Val Ser Phe Gln Phe 
        195                 200                 205             


Phe Phe Asn Ile Ser Thr Asp Asp Gln Glu Gly Leu Tyr Ser Leu Tyr 
    210                 215                 220                 


Phe His Lys Cys Leu Gly Lys Glu Leu Pro Ser Asp Lys Phe Thr Phe 
225                 230                 235                 240 


Ser Leu Asp Ile Glu Ile Thr Glu Lys Asn Pro Asp Ser Tyr Leu Ser 
                245                 250                 255     


Ala Gly Glu Ile Pro Leu Pro Lys Leu Tyr Ile Ser Met Ala Phe Phe 
            260                 265                 270         


Phe Phe Leu Ser Gly Thr Ile Trp Ile His Ile Leu Arg Lys Arg Arg 
        275                 280                 285             


Asn Asp Val Phe Lys Ile His Trp Leu Met Ala Ala Leu Pro Phe Thr 
    290                 295                 300                 


Lys Ser Leu Ser Leu Val Phe His Ala Ile Asp Tyr His Tyr Ile Ser 
305                 310                 315                 320 


Ser Gln Gly Phe Pro Ile Glu Gly Trp Ala Val Val Tyr Tyr Ile Thr 
                325                 330                 335     


His Leu Leu Lys Gly Ala Leu Leu Phe Ile Thr Ile Ala Leu Ile Gly 
            340                 345                 350         


Thr Gly Trp Ala Phe Ile Lys His Ile Leu Ser Asp Lys Asp Lys Lys 
        355                 360                 365             


Ile Phe Met Ile Val Ile Pro Leu Gln Val Leu Ala Asn Val Ala Tyr 
    370                 375                 380                 


Ile Ile Ile Glu Ser Thr Glu Glu Gly Thr Thr Glu Tyr Gly Leu Trp 
385                 390                 395                 400 


Lys Asp Ser Leu Phe Leu Val Asp Leu Leu Cys Cys Gly Ala Ile Leu 
                405                 410                 415     


Phe Pro Val Val Trp Ser Ile Arg His Leu Gln Glu Ala Ser Ala Thr 
            420                 425                 430         


Asp Gly Lys Ala Ala Ile Asn Leu Ala Lys Leu Lys Leu Phe Arg His 
        435                 440                 445             


Tyr Tyr Val Leu Ile Val Cys Tyr Ile Tyr Phe Thr Arg Ile Ile Ala 
    450                 455                 460                 


Phe Leu Leu Lys Leu Ala Val Pro Phe Gln Trp Lys Trp Leu Tyr Gln 
465                 470                 475                 480 


Leu Leu Asp Glu Thr Ala Thr Leu Val Phe Phe Val Leu Thr Gly Tyr 
                485                 490                 495     


Lys Phe Arg Pro Ala Ser Asp Asn Pro Tyr Leu Gln Leu Ser Gln Glu 
            500                 505                 510         


Glu Glu Asp Leu Glu Met Glu Ser Val Val Thr Thr Ser Gly Val Met 
        515                 520                 525             


Glu Ser Met Lys Lys Val Lys Lys Val Thr Asn Gly Ser Val Glu Pro 
    530                 535                 540                 


Gln Gly Glu Trp Glu Gly Ala Val 
545                 550         


<210>  68
<211>  600
<212>  PRT
<213>  Homo sapiens

<400>  68

Met Ala Ala Leu Ala Pro Val Gly Ser Pro Ala Ser Arg Gly Pro Arg 
1               5                   10                  15      


Leu Ala Ala Gly Leu Arg Leu Leu Pro Met Leu Gly Leu Leu Gln Leu 
            20                  25                  30          


Leu Ala Glu Pro Gly Leu Gly Arg Val His His Leu Ala Leu Lys Asp 
        35                  40                  45              


Asp Val Arg His Lys Val His Leu Asn Thr Phe Gly Phe Phe Lys Asp 
    50                  55                  60                  


Gly Tyr Met Val Val Asn Val Ser Ser Leu Ser Leu Asn Glu Pro Glu 
65                  70                  75                  80  


Asp Lys Asp Val Thr Ile Gly Phe Ser Leu Asp Arg Thr Lys Asn Asp 
                85                  90                  95      


Gly Phe Ser Ser Tyr Leu Asp Glu Asp Val Asn Tyr Cys Ile Leu Lys 
            100                 105                 110         


Lys Gln Ser Val Ser Val Thr Leu Leu Ile Leu Asp Ile Ser Arg Ser 
        115                 120                 125             


Glu Val Arg Val Lys Ser Pro Pro Glu Ala Gly Thr Gln Leu Pro Lys 
    130                 135                 140                 


Ile Ile Phe Ser Arg Asp Glu Lys Val Leu Gly Gln Ser Gln Glu Pro 
145                 150                 155                 160 


Asn Val Asn Pro Ala Ser Ala Gly Asn Gln Thr Gln Lys Thr Gln Asp 
                165                 170                 175     


Gly Gly Lys Ser Lys Arg Ser Thr Val Asp Ser Lys Ala Met Gly Glu 
            180                 185                 190         


Lys Ser Phe Ser Val His Asn Asn Gly Gly Ala Val Ser Phe Gln Phe 
        195                 200                 205             


Phe Phe Asn Ile Ser Thr Asp Asp Gln Glu Gly Leu Tyr Ser Leu Tyr 
    210                 215                 220                 


Phe His Lys Cys Leu Gly Lys Glu Leu Pro Ser Asp Lys Phe Thr Phe 
225                 230                 235                 240 


Ser Leu Asp Ile Glu Ile Thr Glu Lys Asn Pro Asp Ser Tyr Leu Ser 
                245                 250                 255     


Ala Gly Glu Ile Pro Leu Pro Lys Leu Tyr Ile Ser Met Ala Phe Phe 
            260                 265                 270         


Phe Phe Leu Ser Gly Thr Ile Trp Ile His Ile Leu Arg Lys Arg Arg 
        275                 280                 285             


Asn Asp Val Phe Lys Ile His Trp Leu Met Ala Ala Leu Pro Phe Thr 
    290                 295                 300                 


Lys Ser Leu Ser Leu Val Phe His Ala Ile Asp Tyr His Tyr Ile Ser 
305                 310                 315                 320 


Ser Gln Gly Phe Pro Ile Glu Gly Trp Ala Val Val Tyr Tyr Ile Thr 
                325                 330                 335     


His Leu Leu Lys Gly Ala Leu Leu Phe Ile Thr Ile Ala Leu Ile Gly 
            340                 345                 350         


Thr Gly Trp Ala Phe Ile Lys His Ile Leu Ser Asp Lys Asp Lys Lys 
        355                 360                 365             


Ile Phe Met Ile Val Ile Pro Leu Gln Val Leu Ala Asn Val Ala Tyr 
    370                 375                 380                 


Ile Ile Ile Glu Ser Thr Glu Glu Gly Thr Thr Glu Tyr Gly Leu Trp 
385                 390                 395                 400 


Lys Asp Ser Leu Phe Leu Val Asp Leu Leu Cys Cys Gly Ala Ile Leu 
                405                 410                 415     


Phe Pro Val Val Trp Ser Ile Arg His Leu Gln Glu Ala Ser Ala Thr 
            420                 425                 430         


Asp Gly Lys Gly Asp Ser Met Gly Pro Leu Gln Gln Arg Ala Asn Leu 
        435                 440                 445             


Arg Ala Gly Ser Arg Ile Glu Ser His His Phe Ala Gln Ala Asp Leu 
    450                 455                 460                 


Glu Leu Leu Ala Ser Ser Cys Pro Pro Ala Ser Val Ser Gln Arg Ala 
465                 470                 475                 480 


Gly Ile Thr Ala Ala Ile Asn Leu Ala Lys Leu Lys Leu Phe Arg His 
                485                 490                 495     


Tyr Tyr Val Leu Ile Val Cys Tyr Ile Tyr Phe Thr Arg Ile Ile Ala 
            500                 505                 510         


Phe Leu Leu Lys Leu Ala Val Pro Phe Gln Trp Lys Trp Leu Tyr Gln 
        515                 520                 525             


Leu Leu Asp Glu Thr Ala Thr Leu Val Phe Phe Val Leu Thr Gly Tyr 
    530                 535                 540                 


Lys Phe Arg Pro Ala Ser Asp Asn Pro Tyr Leu Gln Leu Ser Gln Glu 
545                 550                 555                 560 


Glu Glu Asp Leu Glu Met Glu Ser Val Val Thr Thr Ser Gly Val Met 
                565                 570                 575     


Glu Ser Met Lys Lys Val Lys Lys Val Thr Asn Gly Ser Val Glu Pro 
            580                 585                 590         


Gln Gly Glu Trp Glu Gly Ala Val 
        595                 600 


<210>  69
<211>  600
<212>  PRT
<213>  Homo sapiens

<400>  69

Met Ala Ala Leu Ala Pro Val Gly Ser Pro Ala Ser Arg Gly Pro Arg 
1               5                   10                  15      


Leu Ala Ala Gly Leu Arg Leu Leu Pro Met Leu Gly Leu Leu Gln Leu 
            20                  25                  30          


Leu Ala Glu Pro Gly Leu Gly Arg Val His His Leu Ala Leu Lys Asp 
        35                  40                  45              


Asp Val Arg His Lys Val His Leu Asn Thr Phe Gly Phe Phe Lys Asp 
    50                  55                  60                  


Gly Tyr Met Val Val Asn Val Ser Ser Leu Ser Leu Asn Glu Pro Glu 
65                  70                  75                  80  


Asp Lys Asp Val Thr Ile Gly Phe Ser Leu Asp Arg Thr Lys Asn Asp 
                85                  90                  95      


Gly Phe Ser Ser Tyr Leu Asp Glu Asp Val Asn Tyr Cys Ile Leu Lys 
            100                 105                 110         


Lys Gln Ser Val Ser Val Thr Leu Leu Ile Leu Asp Ile Ser Arg Ser 
        115                 120                 125             


Glu Val Arg Val Lys Ser Pro Pro Glu Ala Gly Thr Gln Leu Pro Lys 
    130                 135                 140                 


Ile Ile Phe Ser Arg Asp Glu Lys Val Leu Gly Gln Ser Gln Glu Pro 
145                 150                 155                 160 


Asn Val Asn Pro Ala Ser Ala Gly Asn Gln Thr Gln Lys Thr Gln Asp 
                165                 170                 175     


Gly Gly Lys Ser Lys Arg Ser Thr Val Asp Ser Lys Ala Met Gly Glu 
            180                 185                 190         


Lys Ser Phe Ser Val His Asn Asn Gly Gly Ala Val Ser Phe Gln Phe 
        195                 200                 205             


Phe Phe Asn Ile Ser Thr Asp Asp Gln Glu Gly Leu Tyr Ser Leu Tyr 
    210                 215                 220                 


Phe His Lys Cys Leu Gly Lys Glu Leu Pro Ser Asp Lys Phe Thr Phe 
225                 230                 235                 240 


Ser Leu Asp Ile Glu Ile Thr Glu Lys Asn Pro Asp Ser Tyr Leu Ser 
                245                 250                 255     


Ala Gly Glu Ile Pro Leu Pro Lys Leu Tyr Ile Ser Met Ala Phe Phe 
            260                 265                 270         


Phe Phe Leu Ser Gly Thr Ile Trp Ile His Ile Leu Arg Lys Arg Arg 
        275                 280                 285             


Asn Asp Val Phe Lys Ile His Trp Leu Met Ala Ala Leu Pro Phe Thr 
    290                 295                 300                 


Lys Ser Leu Ser Leu Val Phe His Ala Ile Asp Tyr His Tyr Ile Ser 
305                 310                 315                 320 


Ser Gln Gly Phe Pro Ile Glu Gly Trp Ala Val Val Tyr Tyr Ile Thr 
                325                 330                 335     


His Leu Leu Lys Gly Ala Leu Leu Phe Ile Thr Ile Ala Leu Ile Gly 
            340                 345                 350         


Thr Gly Trp Ala Phe Ile Lys His Ile Leu Ser Asp Lys Asp Lys Lys 
        355                 360                 365             


Ile Phe Met Ile Val Ile Pro Leu Gln Val Leu Ala Asn Val Ala Tyr 
    370                 375                 380                 


Ile Ile Ile Glu Ser Thr Glu Glu Gly Thr Thr Glu Tyr Gly Leu Trp 
385                 390                 395                 400 


Lys Asp Ser Leu Phe Leu Val Asp Leu Leu Cys Cys Gly Ala Ile Leu 
                405                 410                 415     


Phe Pro Val Val Trp Ser Ile Arg His Leu Gln Glu Ala Ser Ala Thr 
            420                 425                 430         


Asp Gly Lys Gly Asp Ser Met Gly Pro Leu Gln Gln Arg Ala Asn Leu 
        435                 440                 445             


Arg Ala Gly Ser Arg Ile Glu Ser His His Phe Ala Gln Ala Asp Leu 
    450                 455                 460                 


Glu Leu Leu Ala Ser Ser Cys Pro Pro Ala Ser Val Ser Gln Arg Ala 
465                 470                 475                 480 


Gly Ile Thr Ala Ala Ile Asn Leu Ala Lys Leu Lys Leu Phe Arg His 
                485                 490                 495     


Tyr Tyr Val Leu Ile Val Cys Tyr Ile Tyr Phe Thr Arg Ile Ile Ala 
            500                 505                 510         


Phe Leu Leu Lys Leu Ala Val Pro Phe Gln Trp Lys Trp Leu Tyr Gln 
        515                 520                 525             


Leu Leu Asp Glu Thr Ala Thr Leu Val Phe Phe Val Leu Thr Gly Tyr 
    530                 535                 540                 


Lys Phe Arg Pro Ala Ser Asp Asn Pro Tyr Leu Gln Leu Ser Gln Glu 
545                 550                 555                 560 


Glu Glu Asp Leu Glu Met Glu Ser Val Val Thr Thr Ser Gly Val Met 
                565                 570                 575     


Glu Ser Met Lys Lys Val Lys Lys Val Thr Asn Gly Ser Val Glu Pro 
            580                 585                 590         


Gln Gly Glu Trp Glu Gly Ala Val 
        595                 600 


<210>  70
<211>  6874
<212>  DNA
<213>  Homo sapiens

<400>  70
ccgaggtggg cagcacaggc tcctcgacga cttcctaggt cgcaatctcc aggaaaacga     60

ccacagggtc agcggagcta gccgccgagc cccgctcccc gggcccttcc ggcggctgcg    120

ccctttcacc ccggacgtgg gcgggagagg aagcggctgg tgatgctgga acaaacatgg    180

ccgctctggc gcccgtcggc tcccccgcct cccgcggtcc taggctggcc gcgggcctcc    240

ggctgctccc aatgctgggt ttgctgcagt tgctggccga gcctggcctg ggccgcgtcc    300

atcacctggc actcaaggat gatgtgaggc ataaagttca tctgaacacc tttggcttct    360

tcaaggatgg gtacatggtg gtgaatgtca gtagcctctc actgaatgag cctgaagaca    420

aggatgtgac tattggattt agcctagacc gtacaaagaa tgatggcttt tcttcttacc    480

tggatgaaga tgtgaattac tgtattttaa agaaacagtc tgtctctgtc acccttttaa    540

tcctagacat ctccagaagt gaggtaagag taaagtctcc accagaagct ggtacccagt    600

taccaaagat catcttcagc agggatgaga aagtccttgg tcagagccag gagcctaatg    660

ttaaccctgc ttcagcaggc aaccagaccc agaagacaca agatggtgga aagtctaaaa    720

gaagtacagt ggattcaaag gccatgggag agaaatcctt ttctgttcat aataatggtg    780

gggcagtgtc atttcagttt ttctttaaca tcagcactga tgaccaagaa ggcctttaca    840

gtctttattt tcataaatgc cttggaaaag aattgccaag tgacaagttt acattcagcc    900

ttgatattga gatcacagag aagaatcctg acagctacct ctcagcagga gaaattcctc    960

tccccaaatt atacatctca atggcctttt tcttctttct ttctgggacc atctggattc   1020

atatccttcg aaaacgacgg aatgatgtat ttaaaatcca ctggctgatg gcggcccttc   1080

ctttcaccaa gtctctttcc ttggtgttcc atgcaattga ctaccactac atctcctccc   1140

agggcttccc tatcgaaggc tgggctgttg tgtactacat aactcacctt ttgaaagggg   1200

cgctactctt catcaccatt gcactcattg gcactggctg ggctttcatt aagcacatcc   1260

tttctgataa agacaaaaag atcttcatga ttgtcattcc actccaggtc ctggcaaatg   1320

tagcctacat catcatagag tccaccgagg agggcacgac tgaatatggc ttgtggaagg   1380

actctctatt tctggtcgac ctgttgtgtt gtggtgccat cctcttccca gtggtgtggt   1440

caatcagaca tttacaagaa gcatcagcaa cagatggaaa agctgctatt aacttagcaa   1500

agctgaaact tttcagacat tattacgtct tgattgtgtg ttacatatac ttcactagga   1560

tcattgcatt tctcctcaaa ctcgctgttc cattccagtg gaagtggctc taccagctcc   1620

tggatgaaac ggccacactg gtcttctttg ttctaacggg gtataaattc cgtccggctt   1680

cagataaccc ctacctacaa ctttctcagg aagaagaaga cttggaaatg gagtccgttg   1740

tgacaacatc tggggtgatg gaaagtatga agaaagtcaa gaaggtgacc aacggctccg   1800

tggagcccca gggcgagtgg gaaggcgccg tgtgacagag ccgaccctga ggatggcact   1860

gtccaaggaa actgttaact tattcatagt cctattggac agcaggagca gctcctacag   1920

tgaactattg gcaccaccga cagtgacacc agggcacatg gctggagcac agtgccgcgg   1980

aaacctgatt ttgtactctc ttttatggaa acgatctgtg gctgtttaga ggcagctgga   2040

tcctctttca ggcgggaatg ggagggcggg cacagggagg aggagaggaa gagaaaagga   2100

agaattcatt tttaatttag gtttcttttt ttcttcttca tttcggagct ctaaggtgta   2160

tgcagttgtg accccatgtg tggggaagtg tagcaaggac ggctggtgga gggggaagga   2220

gggtgcgagg tgtctgtctg atgctttagg aaatgtctac tgaggaccct gggacttaag   2280

aagaagggcg gggagagtgc cattgcctgt ttgggagaca aaaatgaacg aaaacaggtg   2340

actttggaaa gcaaagtcaa aacccagttt aggatgtagc acctgcccca ggattcctgc   2400

cctcggcttt gccccagacc cttattccag atgctgagag tgaccaggac agcagctcct   2460

gaggcccagt ggtcttcttt ccaacaggaa aagaaggctg tgatgtcgct gtcaggatca   2520

tgccctgtgg cacagcacag gtggtgggag gtggttttct gactgagatg ttgcctgatg   2580

gatggaaaga aatgtatttt taagttcaaa aagcattatc ctgtggcgtt gcctggacat   2640

ccactccctg acagcccaga gcagcactgt ctggcttccc ttcatgcttg tggctttgtt   2700

gtgtttgatc agaattttgg gggaaatgga aagttttcct caaggagcag ctgggggcag   2760

aataggtagt atttaagcaa atacttaagt ccaagcaaat catccccatt aaaaagcttt   2820

tcctgtaggc tagtaggatt tctaaataga tgaattcaac agacttggtc cccatagtcc   2880

aagagtatgt atgtgaagaa agtgagcatg attcaacagt ttcactctca gggattttag   2940

gatggcaaaa tacttcacag aaactcaatg attaagttcc cttccacact tccagagctt   3000

gaatgaacac aggtagccac ctaaattgag cagtattgca actcagagag aaaatcatct   3060

gaatagtagg acaagctcag aaggtacatt gtgactgagg gcttaaaagg agaccaaaac   3120

atggccccat cagggaagct tcttaatgct tggggggcca gctaggtagg gttgcttcca   3180

aaagctggag cccacccctg cctaggggtt gtcagagagc cacacctgca ggggaacagg   3240

tacctccgag ggtgagagtc gtggtctctg ggagttgttt tctcacctct ggcttagaag   3300

ggtcaggcag aaaccacagg atgtggggtc acactcactg tcccaagttt gggaacctga   3360

aaaagtctcc attcagaaca tggttgttct ccctgtccca tgctatctta tcttcctaaa   3420

tgactaatga ggaagcgggt gttctttttc tgcactttga ttcgccatct gggttctgta   3480

gggtgctctg aaggtgtgat ctgccttctg gctgatgtgg aggaagagca agcgccttcc   3540

caggccacag ctgctcacct ctcggcagat attttaggca agcatccgtg tgtcttccca   3600

tcttcaggag aaaggtaaat gcaccctaag tgttcacttc tggacctttt tcaagttcac   3660

ttgggactgt gtgacagaag ggagttggag ggaggatggg aatattttta acactttgtt   3720

ttcctgtgca gaaacataat accagttttc gcagaaatgt gtctcaatct gtgactacca   3780

aagccctcct cagtccttcc ctcagaggga cacatttgct gtttctcccg caagcagatg   3840

ttgtggatga ggcgatagac tccttggcaa gaacgaaagg tgtgatgaaa cctccctgct   3900

cggaagggtc tccgtggagg tgtcctcatt tcacatgctg ggttttgcaa gcgaggaagc   3960

caggcagtgg aggaactaga gagaggcagg cgtgtgtgtg gacaagcgct ggagccgcag   4020

ccctcagact ggcacgggaa cgccagcgtt gggtgttcag attccacgcg tatgtctggg   4080

ctcactcaca gcatggccga gtgtctgcag tgctggtcct gacccttcca gagcagcagt   4140

ggacagatga gataagactg tttcagaaac aaagatggcc acagccttcc taacaagcag   4200

gtcatctggc catgtctgta ttgtaactgg taaaaggctt caagtcagat tgatgatcaa   4260

gaaaagtcaa aaccccagcc caagattggg aaagcaggtg gtggttccaa gcttttaaaa   4320

aattattgaa gctctccatc ctgttctgtg agtgtgtctt ctctttctcc ttcacgtcat   4380

agccgtgacc caccgttcat ctctgctctt gcgtaaagat gaccgatgga gtccaaagcc   4440

aagtggcttc accagctgac aagccaccct cctgcagcct gagtttcaca gtccactggg   4500

ttcgttgtca tgcggtgttt gaatggttaa gcccttgcag tatttcagat cgggcaaaaa   4560

atatcggatg cacatagcag aaccattggt ggtatttata gctttgcttt gtactcctca   4620

ctgtttctgc ctacgcaaaa tatccatgtt tcctctgaga aatctgttgt ggactgaaag   4680

cgctgctggc tgtgaaattt aataaagtgt gtatgctttg ctagaaaatt atttcttgga   4740

caataggaac agtcattgat ctgtaaatcc tggctcttaa cagtgagtgg ccaaggactt   4800

gatcagccca tttcttggtc cctcagtgct ttaaaattta agtagcactg cattttgtaa   4860

tgttgaatat gactctagtg acttgtagga ggcacttgtg aggagatgct tgcttcagtg   4920

taaaagatgc tcatggcctg agtcagttga gttttctttc aagaaaccac ttcagagtga   4980

aatatccagg gtttccccgc cctggacatg tccagcctgc ccaggcagca cacagccctg   5040

taagtccacc tcgtgtgggt gagatttcct cctgcgtgat gacctcatcg ccatctctgc   5100

tgtctcattc cacagcctcc ctccctcttc tctcctcctc tgccctcgcc cttccccctt   5160

ccccatcccc tccccctcct cctctgccct cgcccttacc cctccccctt ccccttccgc   5220

tcctcctccc tcctccacct ctttctcctc ctccttccct cctcctccct cctcttccct   5280

tctctgccat ctttctcccc gtgcctattg atcccacata ggctcattct gggtacaccg   5340

gctaaaggct ttggtgcatt gcagcgtttt ctcccagcag ctgtgtgaaa gatgcatttt   5400

ctaagctaag gagaattttc tcaagagtgg catactcatg ccaaatatta ttgctctggg   5460

ccatataggc tggtcttcct ccacactaaa atgggtgtct tgttttggta cttaaaacag   5520

tctactccag gcatccagtc cttacagacc aaggaagagc atagcgatgc ctgttggaat   5580

tgcagatgca ttctggcctt ctcccccgtc ctgaaacatt ttctttgagg aaggctctta   5640

gaacattaga tagtctgctg aggttgttgg cccagctcca tacacccagt agaacagtgg   5700

aacaactcat gcttcatgct gccaagctgc tgtacttcaa aggaaacaga tctagcacac   5760

tgctgcaccc ctgcttccac actccacact tcaccccgct gcttttctct gacccgcccc   5820

tggccttgta agactcacgt aagctaagtc caggatgcct gtggcctgcg gcttgattct   5880

tccctttagg attcagcaag ttaatggctt cctcgctata gaagtgagac tttgacttga   5940

tgcctcttgg tatatcaaaa agatattcat ccagaaagta ccaaatgttc tgaaagaccc   6000

gctcttcact ccagttttcc ctagggtgtt tctggcaggg cgtttttaaa aggcatctac   6060

ctgagttgac gctaatactt gtcaccacct ggaacgtagt tatcggtcgg caggctgaac   6120

atactccaga ttccccagag gccacttctg tagcccagcg atgcatctga gcctctctgc   6180

gtggtttatg cttgaaaaat agataatgct tttagatggt tcactgccag gccatgggcc   6240

ccacacatct caggccctgt gtgagggagc acactgagat ggtgcaggag tgaatgggca   6300

tggcttggcc tcgctacctc ggggacctgt tggagttctg gcagcagggt gtctgcaggt   6360

gggacggcgt tctgggcaga gtcagaatgg tcagaatgaa acagaacagc caactcaccc   6420

acaggacagc ttattttgag gcaaggtttt ggattttgga ggaagcagcc agatgaggcg   6480

gtgagcctcc agaaggtcag cctttggagc acgtaagata ctgttacagg gtccagaaat   6540

cgtgttcaca tgggggcttt gactcttcaa acagcttttg cagatcgtaa attgcatttg   6600

cctagtcgtg tgacctcaaa agaagtcaga catatttaat ccagaaatag tttcgtttga   6660

gggagggctt gcaggtctgt aaatagcatt tgctttcctg gttagagatt gggatgcaga   6720

aggagttttc agtatttttt ttaaaacact aatgatcatt gaagagtatt tatgtaaaca   6780

tacaacgtat aatgggtggg ggatccgatc atggtgatgt acggggtgaa ttctcttgcc   6840

gtgttgcaaa tgtgtaaaat aaagattatc tggc                               6874


<210>  71
<211>  7018
<212>  DNA
<213>  Homo sapiens

<400>  71
ccgaggtggg cagcacaggc tcctcgacga cttcctaggt cgcaatctcc aggaaaacga     60

ccacagggtc agcggagcta gccgccgagc cccgctcccc gggcccttcc ggcggctgcg    120

ccctttcacc ccggacgtgg gcgggagagg aagcggctgg tgatgctgga acaaacatgg    180

ccgctctggc gcccgtcggc tcccccgcct cccgcggtcc taggctggcc gcgggcctcc    240

ggctgctccc aatgctgggt ttgctgcagt tgctggccga gcctggcctg ggccgcgtcc    300

atcacctggc actcaaggat gatgtgaggc ataaagttca tctgaacacc tttggcttct    360

tcaaggatgg gtacatggtg gtgaatgtca gtagcctctc actgaatgag cctgaagaca    420

aggatgtgac tattggattt agcctagacc gtacaaagaa tgatggcttt tcttcttacc    480

tggatgaaga tgtgaattac tgtattttaa agaaacagtc tgtctctgtc acccttttaa    540

tcctagacat ctccagaagt gaggtaagag taaagtctcc accagaagct ggtacccagt    600

taccaaagat catcttcagc agggatgaga aagtccttgg tcagagccag gagcctaatg    660

ttaaccctgc ttcagcaggc aaccagaccc agaagacaca agatggtgga aagtctaaaa    720

gaagtacagt ggattcaaag gccatgggag agaaatcctt ttctgttcat aataatggtg    780

gggcagtgtc atttcagttt ttctttaaca tcagcactga tgaccaagaa ggcctttaca    840

gtctttattt tcataaatgc cttggaaaag aattgccaag tgacaagttt acattcagcc    900

ttgatattga gatcacagag aagaatcctg acagctacct ctcagcagga gaaattcctc    960

tccccaaatt atacatctca atggcctttt tcttctttct ttctgggacc atctggattc   1020

atatccttcg aaaacgacgg aatgatgtat ttaaaatcca ctggctgatg gcggcccttc   1080

ctttcaccaa gtctctttcc ttggtgttcc atgcaattga ctaccactac atctcctccc   1140

agggcttccc tatcgaaggc tgggctgttg tgtactacat aactcacctt ttgaaagggg   1200

cgctactctt catcaccatt gcactcattg gcactggctg ggctttcatt aagcacatcc   1260

tttctgataa agacaaaaag atcttcatga ttgtcattcc actccaggtc ctggcaaatg   1320

tagcctacat catcatagag tccaccgagg agggcacgac tgaatatggc ttgtggaagg   1380

actctctatt tctggtcgac ctgttgtgtt gtggtgccat cctcttccca gtggtgtggt   1440

caatcagaca tttacaagaa gcatcagcaa cagatggaaa aggtgacagc atgggacctc   1500

ttcagcagag agcgaatcta agagcaggaa gtcgcataga gtctcaccat tttgcccagg   1560

ctgatcttga actcctggcc tctagctgtc ctcctgcctc agtctcccaa agggctggga   1620

ttacagctgc tattaactta gcaaagctga aacttttcag acattattac gtcttgattg   1680

tgtgttacat atacttcact aggatcattg catttctcct caaactcgct gttccattcc   1740

agtggaagtg gctctaccag ctcctggatg aaacggccac actggtcttc tttgttctaa   1800

cggggtataa attccgtccg gcttcagata acccctacct acaactttct caggaagaag   1860

aagacttgga aatggagtcc gttgtgacaa catctggggt gatggaaagt atgaagaaag   1920

tcaagaaggt gaccaacggc tccgtggagc cccagggcga gtgggaaggc gccgtgtgac   1980

agagccgacc ctgaggatgg cactgtccaa ggaaactgtt aacttattca tagtcctatt   2040

ggacagcagg agcagctcct acagtgaact attggcacca ccgacagtga caccagggca   2100

catggctgga gcacagtgcc gcggaaacct gattttgtac tctcttttat ggaaacgatc   2160

tgtggctgtt tagaggcagc tggatcctct ttcaggcggg aatgggaggg cgggcacagg   2220

gaggaggaga ggaagagaaa aggaagaatt catttttaat ttaggtttct ttttttcttc   2280

ttcatttcgg agctctaagg tgtatgcagt tgtgacccca tgtgtgggga agtgtagcaa   2340

ggacggctgg tggaggggga aggagggtgc gaggtgtctg tctgatgctt taggaaatgt   2400

ctactgagga ccctgggact taagaagaag ggcggggaga gtgccattgc ctgtttggga   2460

gacaaaaatg aacgaaaaca ggtgactttg gaaagcaaag tcaaaaccca gtttaggatg   2520

tagcacctgc cccaggattc ctgccctcgg ctttgcccca gacccttatt ccagatgctg   2580

agagtgacca ggacagcagc tcctgaggcc cagtggtctt ctttccaaca ggaaaagaag   2640

gctgtgatgt cgctgtcagg atcatgccct gtggcacagc acaggtggtg ggaggtggtt   2700

ttctgactga gatgttgcct gatggatgga aagaaatgta tttttaagtt caaaaagcat   2760

tatcctgtgg cgttgcctgg acatccactc cctgacagcc cagagcagca ctgtctggct   2820

tcccttcatg cttgtggctt tgttgtgttt gatcagaatt ttgggggaaa tggaaagttt   2880

tcctcaagga gcagctgggg gcagaatagg tagtatttaa gcaaatactt aagtccaagc   2940

aaatcatccc cattaaaaag cttttcctgt aggctagtag gatttctaaa tagatgaatt   3000

caacagactt ggtccccata gtccaagagt atgtatgtga agaaagtgag catgattcaa   3060

cagtttcact ctcagggatt ttaggatggc aaaatacttc acagaaactc aatgattaag   3120

ttcccttcca cacttccaga gcttgaatga acacaggtag ccacctaaat tgagcagtat   3180

tgcaactcag agagaaaatc atctgaatag taggacaagc tcagaaggta cattgtgact   3240

gagggcttaa aaggagacca aaacatggcc ccatcaggga agcttcttaa tgcttggggg   3300

gccagctagg tagggttgct tccaaaagct ggagcccacc cctgcctagg ggttgtcaga   3360

gagccacacc tgcaggggaa caggtacctc cgagggtgag agtcgtggtc tctgggagtt   3420

gttttctcac ctctggctta gaagggtcag gcagaaacca caggatgtgg ggtcacactc   3480

actgtcccaa gtttgggaac ctgaaaaagt ctccattcag aacatggttg ttctccctgt   3540

cccatgctat cttatcttcc taaatgacta atgaggaagc gggtgttctt tttctgcact   3600

ttgattcgcc atctgggttc tgtagggtgc tctgaaggtg tgatctgcct tctggctgat   3660

gtggaggaag agcaagcgcc ttcccaggcc acagctgctc acctctcggc agatatttta   3720

ggcaagcatc cgtgtgtctt cccatcttca ggagaaaggt aaatgcaccc taagtgttca   3780

cttctggacc tttttcaagt tcacttggga ctgtgtgaca gaagggagtt ggagggagga   3840

tgggaatatt tttaacactt tgttttcctg tgcagaaaca taataccagt tttcgcagaa   3900

atgtgtctca atctgtgact accaaagccc tcctcagtcc ttccctcaga gggacacatt   3960

tgctgtttct cccgcaagca gatgttgtgg atgaggcgat agactccttg gcaagaacga   4020

aaggtgtgat gaaacctccc tgctcggaag ggtctccgtg gaggtgtcct catttcacat   4080

gctgggtttt gcaagcgagg aagccaggca gtggaggaac tagagagagg caggcgtgtg   4140

tgtggacaag cgctggagcc gcagccctca gactggcacg ggaacgccag cgttgggtgt   4200

tcagattcca cgcgtatgtc tgggctcact cacagcatgg ccgagtgtct gcagtgctgg   4260

tcctgaccct tccagagcag cagtggacag atgagataag actgtttcag aaacaaagat   4320

ggccacagcc ttcctaacaa gcaggtcatc tggccatgtc tgtattgtaa ctggtaaaag   4380

gcttcaagtc agattgatga tcaagaaaag tcaaaacccc agcccaagat tgggaaagca   4440

ggtggtggtt ccaagctttt aaaaaattat tgaagctctc catcctgttc tgtgagtgtg   4500

tcttctcttt ctccttcacg tcatagccgt gacccaccgt tcatctctgc tcttgcgtaa   4560

agatgaccga tggagtccaa agccaagtgg cttcaccagc tgacaagcca ccctcctgca   4620

gcctgagttt cacagtccac tgggttcgtt gtcatgcggt gtttgaatgg ttaagccctt   4680

gcagtatttc agatcgggca aaaaatatcg gatgcacata gcagaaccat tggtggtatt   4740

tatagctttg ctttgtactc ctcactgttt ctgcctacgc aaaatatcca tgtttcctct   4800

gagaaatctg ttgtggactg aaagcgctgc tggctgtgaa atttaataaa gtgtgtatgc   4860

tttgctagaa aattatttct tggacaatag gaacagtcat tgatctgtaa atcctggctc   4920

ttaacagtga gtggccaagg acttgatcag cccatttctt ggtccctcag tgctttaaaa   4980

tttaagtagc actgcatttt gtaatgttga atatgactct agtgacttgt aggaggcact   5040

tgtgaggaga tgcttgcttc agtgtaaaag atgctcatgg cctgagtcag ttgagttttc   5100

tttcaagaaa ccacttcaga gtgaaatatc cagggtttcc ccgccctgga catgtccagc   5160

ctgcccaggc agcacacagc cctgtaagtc cacctcgtgt gggtgagatt tcctcctgcg   5220

tgatgacctc atcgccatct ctgctgtctc attccacagc ctccctccct cttctctcct   5280

cctctgccct cgcccttccc ccttccccat cccctccccc tcctcctctg ccctcgccct   5340

tacccctccc ccttcccctt ccgctcctcc tccctcctcc acctctttct cctcctcctt   5400

ccctcctcct ccctcctctt cccttctctg ccatctttct ccccgtgcct attgatccca   5460

cataggctca ttctgggtac accggctaaa ggctttggtg cattgcagcg ttttctccca   5520

gcagctgtgt gaaagatgca ttttctaagc taaggagaat tttctcaaga gtggcatact   5580

catgccaaat attattgctc tgggccatat aggctggtct tcctccacac taaaatgggt   5640

gtcttgtttt ggtacttaaa acagtctact ccaggcatcc agtccttaca gaccaaggaa   5700

gagcatagcg atgcctgttg gaattgcaga tgcattctgg ccttctcccc cgtcctgaaa   5760

cattttcttt gaggaaggct cttagaacat tagatagtct gctgaggttg ttggcccagc   5820

tccatacacc cagtagaaca gtggaacaac tcatgcttca tgctgccaag ctgctgtact   5880

tcaaaggaaa cagatctagc acactgctgc acccctgctt ccacactcca cacttcaccc   5940

cgctgctttt ctctgacccg cccctggcct tgtaagactc acgtaagcta agtccaggat   6000

gcctgtggcc tgcggcttga ttcttccctt taggattcag caagttaatg gcttcctcgc   6060

tatagaagtg agactttgac ttgatgcctc ttggtatatc aaaaagatat tcatccagaa   6120

agtaccaaat gttctgaaag acccgctctt cactccagtt ttccctaggg tgtttctggc   6180

agggcgtttt taaaaggcat ctacctgagt tgacgctaat acttgtcacc acctggaacg   6240

tagttatcgg tcggcaggct gaacatactc cagattcccc agaggccact tctgtagccc   6300

agcgatgcat ctgagcctct ctgcgtggtt tatgcttgaa aaatagataa tgcttttaga   6360

tggttcactg ccaggccatg ggccccacac atctcaggcc ctgtgtgagg gagcacactg   6420

agatggtgca ggagtgaatg ggcatggctt ggcctcgcta cctcggggac ctgttggagt   6480

tctggcagca gggtgtctgc aggtgggacg gcgttctggg cagagtcaga atggtcagaa   6540

tgaaacagaa cagccaactc acccacagga cagcttattt tgaggcaagg ttttggattt   6600

tggaggaagc agccagatga ggcggtgagc ctccagaagg tcagcctttg gagcacgtaa   6660

gatactgtta cagggtccag aaatcgtgtt cacatggggg ctttgactct tcaaacagct   6720

tttgcagatc gtaaattgca tttgcctagt cgtgtgacct caaaagaagt cagacatatt   6780

taatccagaa atagtttcgt ttgagggagg gcttgcaggt ctgtaaatag catttgcttt   6840

cctggttaga gattgggatg cagaaggagt tttcagtatt ttttttaaaa cactaatgat   6900

cattgaagag tatttatgta aacatacaac gtataatggg tgggggatcc gatcatggtg   6960

atgtacgggg tgaattctct tgccgtgttg caaatgtgta aaataaagat tatctggc     7018


<210>  72
<211>  7353
<212>  DNA
<213>  Homo sapiens

<400>  72
attattgcaa ccatttcgct tgtatttgag tgtgaagcgc ctagaaaacc acaggacccc     60

tacggcgagc cgggaatttt tagatatttt cctccgagtc aacgctcagt gaaatcagtt    120

caatcagtgg cccgacaccg tgcggctgac acagcttatc ccccgaccct gagatcaggg    180

gtccccggag cccaaggtcg cttccaaagc tcagcgaggc ggaggtgcgg cccgggctgg    240

tctggttcgg ccaccgttgt tatggcaacc gccaataggt tggcttcatc tctaactgaa    300

agtctgcaca ggagcggccg atcgaagggc cccgaggtgg gcagcacagg ctcctcgacg    360

acttcctagg tcgcaatctc caggaaaacg accacagggt cagcggagct agccgccgag    420

ccccgctccc cgggcccttc cggcggctgc gccctttcac cccggacgtg ggcgggagag    480

gaagcggctg gtgatgctgg aacaaacatg gccgctctgg cgcccgtcgg ctcccccgcc    540

tcccgcggtc ctaggctggc cgcgggcctc cggctgctcc caatgctggg tttgctgcag    600

ttgctggccg agcctggcct gggccgcgtc catcacctgg cactcaagga tgatgtgagg    660

cataaagttc atctgaacac ctttggcttc ttcaaggatg ggtacatggt ggtgaatgtc    720

agtagcctct cactgaatga gcctgaagac aaggatgtga ctattggatt tagcctagac    780

cgtacaaaga atgatggctt ttcttcttac ctggatgaag atgtgaatta ctgtatttta    840

aagaaacagt ctgtctctgt caccctttta atcctagaca tctccagaag tgaggtaaga    900

gtaaagtctc caccagaagc tggtacccag ttaccaaaga tcatcttcag cagggatgag    960

aaagtccttg gtcagagcca ggagcctaat gttaaccctg cttcagcagg caaccagacc   1020

cagaagacac aagatggtgg aaagtctaaa agaagtacag tggattcaaa ggccatggga   1080

gagaaatcct tttctgttca taataatggt ggggcagtgt catttcagtt tttctttaac   1140

atcagcactg atgaccaaga aggcctttac agtctttatt ttcataaatg ccttggaaaa   1200

gaattgccaa gtgacaagtt tacattcagc cttgatattg agatcacaga gaagaatcct   1260

gacagctacc tctcagcagg agaaattcct ctccccaaat tatacatctc aatggccttt   1320

ttcttctttc tttctgggac catctggatt catatccttc gaaaacgacg gaatgatgta   1380

tttaaaatcc actggctgat ggcggccctt cctttcacca agtctctttc cttggtgttc   1440

catgcaattg actaccacta catctcctcc cagggcttcc ctatcgaagg ctgggctgtt   1500

gtgtactaca taactcacct tttgaaaggg gcgctactct tcatcaccat tgcactcatt   1560

ggcactggct gggctttcat taagcacatc ctttctgata aagacaaaaa gatcttcatg   1620

attgtcattc cactccaggt cctggcaaat gtagcctaca tcatcataga gtccaccgag   1680

gagggcacga ctgaatatgg cttgtggaag gactctctat ttctggtcga cctgttgtgt   1740

tgtggtgcca tcctcttccc agtggtgtgg tcaatcagac atttacaaga agcatcagca   1800

acagatggaa aaggtgacag catgggacct cttcagcaga gagcgaatct aagagcagga   1860

agtcgcatag agtctcacca ttttgcccag gctgatcttg aactcctggc ctctagctgt   1920

cctcctgcct cagtctccca aagggctggg attacagctg ctattaactt agcaaagctg   1980

aaacttttca gacattatta cgtcttgatt gtgtgttaca tatacttcac taggatcatt   2040

gcatttctcc tcaaactcgc tgttccattc cagtggaagt ggctctacca gctcctggat   2100

gaaacggcca cactggtctt ctttgttcta acggggtata aattccgtcc ggcttcagat   2160

aacccctacc tacaactttc tcaggaagaa gaagacttgg aaatggagtc cgttgtgaca   2220

acatctgggg tgatggaaag tatgaagaaa gtcaagaagg tgaccaacgg ctccgtggag   2280

ccccagggcg agtgggaagg cgccgtgtga cagagccgac cctgaggatg gcactgtcca   2340

aggaaactgt taacttattc atagtcctat tggacagcag gagcagctcc tacagtgaac   2400

tattggcacc accgacagtg acaccagggc acatggctgg agcacagtgc cgcggaaacc   2460

tgattttgta ctctctttta tggaaacgat ctgtggctgt ttagaggcag ctggatcctc   2520

tttcaggcgg gaatgggagg gcgggcacag ggaggaggag aggaagagaa aaggaagaat   2580

tcatttttaa tttaggtttc tttttttctt cttcatttcg gagctctaag gtgtatgcag   2640

ttgtgacccc atgtgtgggg aagtgtagca aggacggctg gtggaggggg aaggagggtg   2700

cgaggtgtct gtctgatgct ttaggaaatg tctactgagg accctgggac ttaagaagaa   2760

gggcggggag agtgccattg cctgtttggg agacaaaaat gaacgaaaac aggtgacttt   2820

ggaaagcaaa gtcaaaaccc agtttaggat gtagcacctg ccccaggatt cctgccctcg   2880

gctttgcccc agacccttat tccagatgct gagagtgacc aggacagcag ctcctgaggc   2940

ccagtggtct tctttccaac aggaaaagaa ggctgtgatg tcgctgtcag gatcatgccc   3000

tgtggcacag cacaggtggt gggaggtggt tttctgactg agatgttgcc tgatggatgg   3060

aaagaaatgt atttttaagt tcaaaaagca ttatcctgtg gcgttgcctg gacatccact   3120

ccctgacagc ccagagcagc actgtctggc ttcccttcat gcttgtggct ttgttgtgtt   3180

tgatcagaat tttgggggaa atggaaagtt ttcctcaagg agcagctggg ggcagaatag   3240

gtagtattta agcaaatact taagtccaag caaatcatcc ccattaaaaa gcttttcctg   3300

taggctagta ggatttctaa atagatgaat tcaacagact tggtccccat agtccaagag   3360

tatgtatgtg aagaaagtga gcatgattca acagtttcac tctcagggat tttaggatgg   3420

caaaatactt cacagaaact caatgattaa gttcccttcc acacttccag agcttgaatg   3480

aacacaggta gccacctaaa ttgagcagta ttgcaactca gagagaaaat catctgaata   3540

gtaggacaag ctcagaaggt acattgtgac tgagggctta aaaggagacc aaaacatggc   3600

cccatcaggg aagcttctta atgcttgggg ggccagctag gtagggttgc ttccaaaagc   3660

tggagcccac ccctgcctag gggttgtcag agagccacac ctgcagggga acaggtacct   3720

ccgagggtga gagtcgtggt ctctgggagt tgttttctca cctctggctt agaagggtca   3780

ggcagaaacc acaggatgtg gggtcacact cactgtccca agtttgggaa cctgaaaaag   3840

tctccattca gaacatggtt gttctccctg tcccatgcta tcttatcttc ctaaatgact   3900

aatgaggaag cgggtgttct ttttctgcac tttgattcgc catctgggtt ctgtagggtg   3960

ctctgaaggt gtgatctgcc ttctggctga tgtggaggaa gagcaagcgc cttcccaggc   4020

cacagctgct cacctctcgg cagatatttt aggcaagcat ccgtgtgtct tcccatcttc   4080

aggagaaagg taaatgcacc ctaagtgttc acttctggac ctttttcaag ttcacttggg   4140

actgtgtgac agaagggagt tggagggagg atgggaatat ttttaacact ttgttttcct   4200

gtgcagaaac ataataccag ttttcgcaga aatgtgtctc aatctgtgac taccaaagcc   4260

ctcctcagtc cttccctcag agggacacat ttgctgtttc tcccgcaagc agatgttgtg   4320

gatgaggcga tagactcctt ggcaagaacg aaaggtgtga tgaaacctcc ctgctcggaa   4380

gggtctccgt ggaggtgtcc tcatttcaca tgctgggttt tgcaagcgag gaagccaggc   4440

agtggaggaa ctagagagag gcaggcgtgt gtgtggacaa gcgctggagc cgcagccctc   4500

agactggcac gggaacgcca gcgttgggtg ttcagattcc acgcgtatgt ctgggctcac   4560

tcacagcatg gccgagtgtc tgcagtgctg gtcctgaccc ttccagagca gcagtggaca   4620

gatgagataa gactgtttca gaaacaaaga tggccacagc cttcctaaca agcaggtcat   4680

ctggccatgt ctgtattgta actggtaaaa ggcttcaagt cagattgatg atcaagaaaa   4740

gtcaaaaccc cagcccaaga ttgggaaagc aggtggtggt tccaagcttt taaaaaatta   4800

ttgaagctct ccatcctgtt ctgtgagtgt gtcttctctt tctccttcac gtcatagccg   4860

tgacccaccg ttcatctctg ctcttgcgta aagatgaccg atggagtcca aagccaagtg   4920

gcttcaccag ctgacaagcc accctcctgc agcctgagtt tcacagtcca ctgggttcgt   4980

tgtcatgcgg tgtttgaatg gttaagccct tgcagtattt cagatcgggc aaaaaatatc   5040

ggatgcacat agcagaacca ttggtggtat ttatagcttt gctttgtact cctcactgtt   5100

tctgcctacg caaaatatcc atgtttcctc tgagaaatct gttgtggact gaaagcgctg   5160

ctggctgtga aatttaataa agtgtgtatg ctttgctaga aaattatttc ttggacaata   5220

ggaacagtca ttgatctgta aatcctggct cttaacagtg agtggccaag gacttgatca   5280

gcccatttct tggtccctca gtgctttaaa atttaagtag cactgcattt tgtaatgttg   5340

aatatgactc tagtgacttg taggaggcac ttgtgaggag atgcttgctt cagtgtaaaa   5400

gatgctcatg gcctgagtca gttgagtttt ctttcaagaa accacttcag agtgaaatat   5460

ccagggtttc cccgccctgg acatgtccag cctgcccagg cagcacacag ccctgtaagt   5520

ccacctcgtg tgggtgagat ttcctcctgc gtgatgacct catcgccatc tctgctgtct   5580

cattccacag cctccctccc tcttctctcc tcctctgccc tcgcccttcc cccttcccca   5640

tcccctcccc ctcctcctct gccctcgccc ttacccctcc cccttcccct tccgctcctc   5700

ctccctcctc cacctctttc tcctcctcct tccctcctcc tccctcctct tcccttctct   5760

gccatctttc tccccgtgcc tattgatccc acataggctc attctgggta caccggctaa   5820

aggctttggt gcattgcagc gttttctccc agcagctgtg tgaaagatgc attttctaag   5880

ctaaggagaa ttttctcaag agtggcatac tcatgccaaa tattattgct ctgggccata   5940

taggctggtc ttcctccaca ctaaaatggg tgtcttgttt tggtacttaa aacagtctac   6000

tccaggcatc cagtccttac agaccaagga agagcatagc gatgcctgtt ggaattgcag   6060

atgcattctg gccttctccc ccgtcctgaa acattttctt tgaggaaggc tcttagaaca   6120

ttagatagtc tgctgaggtt gttggcccag ctccatacac ccagtagaac agtggaacaa   6180

ctcatgcttc atgctgccaa gctgctgtac ttcaaaggaa acagatctag cacactgctg   6240

cacccctgct tccacactcc acacttcacc ccgctgcttt tctctgaccc gcccctggcc   6300

ttgtaagact cacgtaagct aagtccagga tgcctgtggc ctgcggcttg attcttccct   6360

ttaggattca gcaagttaat ggcttcctcg ctatagaagt gagactttga cttgatgcct   6420

cttggtatat caaaaagata ttcatccaga aagtaccaaa tgttctgaaa gacccgctct   6480

tcactccagt tttccctagg gtgtttctgg cagggcgttt ttaaaaggca tctacctgag   6540

ttgacgctaa tacttgtcac cacctggaac gtagttatcg gtcggcaggc tgaacatact   6600

ccagattccc cagaggccac ttctgtagcc cagcgatgca tctgagcctc tctgcgtggt   6660

ttatgcttga aaaatagata atgcttttag atggttcact gccaggccat gggccccaca   6720

catctcaggc cctgtgtgag ggagcacact gagatggtgc aggagtgaat gggcatggct   6780

tggcctcgct acctcgggga cctgttggag ttctggcagc agggtgtctg caggtgggac   6840

ggcgttctgg gcagagtcag aatggtcaga atgaaacaga acagccaact cacccacagg   6900

acagcttatt ttgaggcaag gttttggatt ttggaggaag cagccagatg aggcggtgag   6960

cctccagaag gtcagccttt ggagcacgta agatactgtt acagggtcca gaaatcgtgt   7020

tcacatgggg gctttgactc ttcaaacagc ttttgcagat cgtaaattgc atttgcctag   7080

tcgtgtgacc tcaaaagaag tcagacatat ttaatccaga aatagtttcg tttgagggag   7140

ggcttgcagg tctgtaaata gcatttgctt tcctggttag agattgggat gcagaaggag   7200

ttttcagtat tttttttaaa acactaatga tcattgaaga gtatttatgt aaacatacaa   7260

cgtataatgg gtgggggatc cgatcatggt gatgtacggg gtgaattctc ttgccgtgtt   7320

gcaaatgtgt aaaataaaga ttatctggca gaa                                7353


<210>  73
<211>  431
<212>  PRT
<213>  Homo sapiens

<400>  73

Met Arg Arg Leu Arg Arg Leu Ala His Leu Val Leu Phe Cys Pro Phe 
1               5                   10                  15      


Ser Lys Arg Leu Gln Gly Arg Leu Pro Gly Leu Arg Val Arg Cys Ile 
            20                  25                  30          


Phe Leu Ala Trp Leu Gly Val Phe Ala Gly Ser Trp Leu Val Tyr Val 
        35                  40                  45              


His Tyr Ser Ser Tyr Ser Glu Arg Cys Arg Gly His Val Cys Gln Val 
    50                  55                  60                  


Val Ile Cys Asp Gln Tyr Arg Lys Gly Ile Ile Ser Gly Ser Val Cys 
65                  70                  75                  80  


Gln Asp Leu Cys Glu Leu His Met Val Glu Trp Arg Thr Cys Leu Ser 
                85                  90                  95      


Val Ala Pro Gly Gln Gln Val Tyr Ser Gly Leu Trp Arg Asp Lys Asp 
            100                 105                 110         


Val Thr Ile Lys Cys Gly Ile Glu Glu Thr Leu Asp Ser Lys Ala Arg 
        115                 120                 125             


Ser Asp Ala Ala Pro Arg Arg Glu Leu Val Leu Phe Asp Lys Pro Thr 
    130                 135                 140                 


Arg Gly Thr Ser Ile Lys Glu Phe Arg Glu Met Thr Leu Ser Phe Leu 
145                 150                 155                 160 


Lys Ala Asn Leu Gly Asp Leu Pro Ser Leu Pro Ala Leu Val Gly Gln 
                165                 170                 175     


Val Leu Leu Met Ala Asp Phe Asn Lys Asp Asn Arg Val Ser Leu Ala 
            180                 185                 190         


Glu Ala Lys Ser Val Trp Ala Leu Leu Gln Arg Asn Glu Phe Leu Leu 
        195                 200                 205             


Leu Leu Ser Leu Gln Glu Lys Glu His Ala Ser Arg Leu Leu Gly Tyr 
    210                 215                 220                 


Cys Gly Asp Leu Tyr Leu Thr Glu Gly Val Pro His Gly Ala Trp His 
225                 230                 235                 240 


Ala Ala Ala Leu Pro Pro Leu Leu Arg Pro Leu Leu Pro Pro Ala Leu 
                245                 250                 255     


Gln Gly Ala Leu Gln Gln Trp Leu Gly Pro Ala Trp Pro Trp Arg Ala 
            260                 265                 270         


Lys Ile Ala Ile Gly Leu Leu Glu Phe Val Glu Glu Leu Phe His Gly 
        275                 280                 285             


Ser Tyr Gly Thr Phe Tyr Met Cys Glu Thr Thr Leu Ala Asn Val Gly 
    290                 295                 300                 


Tyr Thr Ala Thr Tyr Asp Phe Lys Met Ala Asp Leu Gln Gln Val Ala 
305                 310                 315                 320 


Pro Glu Ala Thr Val Arg Arg Phe Leu Gln Gly Arg Arg Cys Glu His 
                325                 330                 335     


Ser Thr Asp Cys Thr Tyr Gly Arg Asp Cys Arg Ala Pro Cys Asp Arg 
            340                 345                 350         


Leu Met Arg Gln Cys Lys Gly Asp Leu Ile Gln Pro Asn Leu Ala Lys 
        355                 360                 365             


Val Cys Ala Leu Leu Arg Gly Tyr Leu Leu Pro Gly Ala Pro Ala Asp 
    370                 375                 380                 


Leu Arg Glu Glu Leu Gly Thr Gln Leu Arg Thr Cys Thr Thr Leu Ser 
385                 390                 395                 400 


Gly Leu Ala Ser Gln Val Glu Ala His His Ser Leu Val Leu Ser His 
                405                 410                 415     


Leu Lys Thr Leu Leu Trp Lys Lys Ile Ser Asn Thr Lys Tyr Ser 
            420                 425                 430     


<210>  74
<211>  344
<212>  PRT
<213>  Homo sapiens

<400>  74

Met Val Glu Trp Arg Thr Cys Leu Ser Val Ala Pro Gly Gln Gln Val 
1               5                   10                  15      


Tyr Ser Gly Leu Trp Arg Asp Lys Asp Val Thr Ile Lys Cys Gly Ile 
            20                  25                  30          


Glu Glu Thr Leu Asp Ser Lys Ala Arg Ser Asp Ala Ala Pro Arg Arg 
        35                  40                  45              


Glu Leu Val Leu Phe Asp Lys Pro Thr Arg Gly Thr Ser Ile Lys Glu 
    50                  55                  60                  


Phe Arg Glu Met Thr Leu Ser Phe Leu Lys Ala Asn Leu Gly Asp Leu 
65                  70                  75                  80  


Pro Ser Leu Pro Ala Leu Val Gly Gln Val Leu Leu Met Ala Asp Phe 
                85                  90                  95      


Asn Lys Asp Asn Arg Val Ser Leu Ala Glu Ala Lys Ser Val Trp Ala 
            100                 105                 110         


Leu Leu Gln Arg Asn Glu Phe Leu Leu Leu Leu Ser Leu Gln Glu Lys 
        115                 120                 125             


Glu His Ala Ser Arg Leu Leu Gly Tyr Cys Gly Asp Leu Tyr Leu Thr 
    130                 135                 140                 


Glu Gly Val Pro His Gly Ala Trp His Ala Ala Ala Leu Pro Pro Leu 
145                 150                 155                 160 


Leu Arg Pro Leu Leu Pro Pro Ala Leu Gln Gly Ala Leu Gln Gln Trp 
                165                 170                 175     


Leu Gly Pro Ala Trp Pro Trp Arg Ala Lys Ile Ala Ile Gly Leu Leu 
            180                 185                 190         


Glu Phe Val Glu Glu Leu Phe His Gly Ser Tyr Gly Thr Phe Tyr Met 
        195                 200                 205             


Cys Glu Thr Thr Leu Ala Asn Val Gly Tyr Thr Ala Thr Tyr Asp Phe 
    210                 215                 220                 


Lys Met Ala Asp Leu Gln Gln Val Ala Pro Glu Ala Thr Val Arg Arg 
225                 230                 235                 240 


Phe Leu Gln Gly Arg Arg Cys Glu His Ser Thr Asp Cys Thr Tyr Gly 
                245                 250                 255     


Arg Asp Cys Arg Ala Pro Cys Asp Arg Leu Met Arg Gln Cys Lys Gly 
            260                 265                 270         


Asp Leu Ile Gln Pro Asn Leu Ala Lys Val Cys Ala Leu Leu Arg Gly 
        275                 280                 285             


Tyr Leu Leu Pro Gly Ala Pro Ala Asp Leu Arg Glu Glu Leu Gly Thr 
    290                 295                 300                 


Gln Leu Arg Thr Cys Thr Thr Leu Ser Gly Leu Ala Ser Gln Val Glu 
305                 310                 315                 320 


Ala His His Ser Leu Val Leu Ser His Leu Lys Thr Leu Leu Trp Lys 
                325                 330                 335     


Lys Ile Ser Asn Thr Lys Tyr Ser 
            340                 


<210>  75
<211>  1645
<212>  DNA
<213>  Homo sapiens

<400>  75
agggagcggc ggccgctgcg ggccgggccg ggccggggct gaggccgagc gagccgcggg     60

gcccgcgcag ccccggccgg agcccaccat gcggcggctg cggcgcctgg cgcacctggt    120

gctcttctgc cccttctcca agcgcctgca gggccggctc ccaggcctca gggtccgctg    180

catcttcctg gcctggctgg gcgtctttgc aggcagctgg ctggtgtacg tgcactactc    240

gtcctactcg gagcgctgtc gcggccatgt ctgccaggtg gtcatttgtg accagtaccg    300

caaggggatc atctcgggct ccgtctgcca ggacctgtgt gagctgcata tggtggagtg    360

gaggacctgc ctctcggtgg ccccgggcca gcaggtgtac agcgggctct ggcgggacaa    420

ggatgtaacc atcaagtgtg gcattgagga gaccctcgac tccaaggccc ggtcggatgc    480

ggccccccgg cgggagctgg tactgtttga caagcccacc cggggcacct ccatcaagga    540

attccgggag atgaccctca gcttcctcaa ggcgaacctg ggagacctgc cttccctgcc    600

ggcgctggtt ggccaggtcc tgctcatggc tgacttcaac aaggacaacc gggtgtccct    660

ggcggaagcc aagtccgtgt gggccctgct gcagcgtaac gagttcctgc tgctgctgtc    720

cctgcaggag aaggagcacg cctccagact gctgggctac tgtggggacc tctacctcac    780

cgagggcgtg ccgcatggcg cctggcacgc ggccgccctt ccacccctgt tgcgcccact    840

gctgccgcct gccctgcagg gtgctctcca gcagtggctg gggcctgcgt ggccttggcg    900

ggccaagatc gccatcggcc tgctggagtt cgtggaggag ctcttccacg gctcttacgg    960

gactttctac atgtgtgaga ccacactggc caacgtgggc tacacagcca cctacgactt   1020

caagatggcc gacctgcagc aggtggcacc cgaggccacc gtgcgccgct tcctgcaggg   1080

ccgccgctgc gagcacagca ccgactgcac ctacgggcgc gactgcaggg ccccgtgtga   1140

caggctcatg aggcagtgca agggcgacct catccagccc aacctggcca aggtgtgcgc   1200

actgctacgg ggctacctgc tgcctggcgc gcccgccgac ctccgcgagg agctgggcac   1260

acagctgcgc acctgtacca cgctgagcgg gctggccagc caggtggagg cccatcactc   1320

gctggtgctc agccacctca agactctgct ctggaagaag atctccaaca ccaagtactc   1380

ttgatggggc agtgaggggc ctggccaccc ttcctggagc tggccaggtg ccagggtcca   1440

accctccctc aaggaatcct gtcagaagat gtgaaatgca actgtgttgc aaaatcactc   1500

ccctaccgtc agggctctgg attccagcac cacagacatg agaccccagc tcggagcaaa   1560

ggcggacatg gacatcccgg caggagagtc ctccaagggg gtttgttact ctgaagaacg   1620

taatgtcaat aaacagcttt tatgt                                         1645


<210>  76
<211>  2410
<212>  DNA
<213>  Homo sapiens

<400>  76
ggccgcagcc tgtcctcctg cctcagcctg gggaaggctg ggccgggcca aagagggagg     60

ccaagtcctt gggacaggag gagacccaca cctgagatta gtggaaaccc agccagaagc    120

tgccatgcag gtgtggctct gggcatcagg atctgtcgtg agagccccca tgagtgccca    180

gtgcagaatg gctggcagcc cgccctgacg gggagcagag gggctggacg cggtgccctt    240

cacgggatga cacccagctg tttgccctgt gtccaggggg ttgcttctct gacagaggcc    300

ctatggctcg tgtctgactc ctgtccaggt tctgccagcc tgaccatcca tcgctctggc    360

accaagagcc cacccttttg ttcttcctgg cgtcccaggg aaagccctgc ctgggtgggg    420

cagctcctgg cccttcagat ggaagacgca gtccagtcag caccatcata ggaaacaagt    480

tcagaaatgt ctcacttact attccgggca gggagggcgc catgagtcag ggggtgcatc    540

ctccctcctg gcgtcacccg aggcaggaat gaagagtcag gcagagagcg cgcgtgtggc    600

agctggtggt gtagatatta gggactagtg tgaattctag ttcaccggcc aatgcctgga    660

tggtccagag ctgggtcggc tgggcggaga gctgcctcca ggttcctgcc tctggccctg    720

gcgtggggtc gacactgggt gtggtgtgtg tctcatgtcc aggcagtggc ctttgctgtg    780

ccgtcctgtt acaggagcca ggatggtggg gacgggaccg gaccggaggg ttggcggggc    840

tgcccctgca gccgacagcc ccatcctgca gccaccaatg gcatgaccca gggccccggc    900

actgcctgtg tgaggggctg gcagctttcc aactgcagca agtggaggcc cctgccagct    960

tcgggcctgt gggcaggggc tcagtggggc aggggtgtgg ctgccccgcc cggcacgcct   1020

gcacctgtct cctcagtgtg accagtaccg caaggggatc atctcgggct ccgtctgcca   1080

ggacctgtgt gagctgcata tggtggagtg gaggacctgc ctctcggtgg ccccgggcca   1140

gcaggtgtac agcgggctct ggcgggacaa ggatgtaacc atcaagtgtg gcattgagga   1200

gaccctcgac tccaaggccc ggtcggatgc ggccccccgg cgggagctgg tactgtttga   1260

caagcccacc cggggcacct ccatcaagga attccgggag atgaccctca gcttcctcaa   1320

ggcgaacctg ggagacctgc cttccctgcc ggcgctggtt ggccaggtcc tgctcatggc   1380

tgacttcaac aaggacaacc gggtgtccct ggcggaagcc aagtccgtgt gggccctgct   1440

gcagcgtaac gagttcctgc tgctgctgtc cctgcaggag aaggagcacg cctccagact   1500

gctgggctac tgtggggacc tctacctcac cgagggcgtg ccgcatggcg cctggcacgc   1560

ggccgccctt ccacccctgt tgcgcccact gctgccgcct gccctgcagg gtgctctcca   1620

gcagtggctg gggcctgcgt ggccttggcg ggccaagatc gccatcggcc tgctggagtt   1680

cgtggaggag ctcttccacg gctcttacgg gactttctac atgtgtgaga ccacactggc   1740

caacgtgggc tacacagcca cctacgactt caagatggcc gacctgcagc aggtggcacc   1800

cgaggccacc gtgcgccgct tcctgcaggg ccgccgctgc gagcacagca ccgactgcac   1860

ctacgggcgc gactgcaggg ccccgtgtga caggctcatg aggcagtgca agggcgacct   1920

catccagccc aacctggcca aggtgtgcgc actgctacgg ggctacctgc tgcctggcgc   1980

gcccgccgac ctccgcgagg agctgggcac acagctgcgc acctgtacca cgctgagcgg   2040

gctggccagc caggtggagg cccatcactc gctggtgctc agccacctca agactctgct   2100

ctggaagaag atctccaaca ccaagtactc ttgatggggc agtgaggggc ctggccaccc   2160

ttcctggagc tggccaggtg ccagggtcca accctccctc aaggaatcct gtcagaagat   2220

gtgaaatgca actgtgttgc aaaatcactc ccctaccgtc agggctctgg attccagcac   2280

cacagacatg agaccccagc tcggagcaaa ggcggacatg gacatcccgg caggagagtc   2340

ctccaagggg gtttgttact ctgaagaacg taatgtcaat aaacagcttt tatgtaatgc   2400

ccagggctga                                                          2410


<210>  77
<211>  409
<212>  PRT
<213>  Homo sapiens

<400>  77

Met Glu Glu Ser Trp Glu Ala Ala Pro Gly Gly Gln Ala Gly Ala Glu 
1               5                   10                  15      


Leu Pro Met Glu Pro Val Gly Ser Leu Val Pro Thr Leu Glu Gln Pro 
            20                  25                  30          


Gln Val Pro Ala Lys Val Arg Gln Pro Glu Gly Pro Glu Ser Ser Pro 
        35                  40                  45              


Ser Pro Ala Gly Ala Val Glu Lys Ala Ala Gly Ala Gly Leu Glu Pro 
    50                  55                  60                  


Ser Ser Lys Lys Lys Pro Pro Ser Pro Arg Pro Gly Ser Pro Arg Val 
65                  70                  75                  80  


Pro Pro Leu Ser Leu Gly Tyr Gly Val Cys Pro Glu Pro Pro Ser Pro 
                85                  90                  95      


Gly Pro Ala Leu Val Lys Leu Pro Arg Asn Gly Glu Ala Pro Gly Ala 
            100                 105                 110         


Glu Pro Ala Pro Ser Ala Trp Ala Pro Met Glu Leu Gln Val Asp Val 
        115                 120                 125             


Arg Val Lys Pro Val Gly Ala Ala Gly Gly Ser Ser Thr Pro Ser Pro 
    130                 135                 140                 


Arg Pro Ser Thr Arg Phe Leu Lys Val Pro Val Pro Glu Ser Pro Ala 
145                 150                 155                 160 


Phe Ser Arg His Ala Asp Pro Ala His Gln Leu Leu Leu Arg Ala Pro 
                165                 170                 175     


Ser Gln Gly Gly Thr Trp Gly Arg Arg Ser Pro Leu Ala Ala Ala Arg 
            180                 185                 190         


Thr Glu Ser Gly Cys Asp Ala Glu Gly Arg Ala Ser Pro Ala Glu Gly 
        195                 200                 205             


Ser Ala Gly Ser Pro Gly Ser Pro Thr Cys Cys Arg Cys Lys Glu Leu 
    210                 215                 220                 


Gly Leu Glu Lys Glu Asp Ala Ala Leu Leu Pro Arg Ala Gly Leu Asp 
225                 230                 235                 240 


Gly Asp Glu Lys Leu Pro Arg Ala Val Thr Leu Thr Gly Leu Pro Met 
                245                 250                 255     


Tyr Val Lys Ser Leu Tyr Trp Ala Leu Ala Phe Met Ala Val Leu Leu 
            260                 265                 270         


Ala Val Ser Gly Val Val Ile Val Val Leu Ala Ser Arg Ala Gly Ala 
        275                 280                 285             


Arg Cys Gln Gln Cys Pro Pro Gly Trp Val Leu Ser Glu Glu His Cys 
    290                 295                 300                 


Tyr Tyr Phe Ser Ala Glu Ala Gln Ala Trp Glu Ala Ser Gln Ala Phe 
305                 310                 315                 320 


Cys Ser Ala Tyr His Ala Thr Leu Pro Leu Leu Ser His Thr Gln Asp 
                325                 330                 335     


Phe Leu Gly Arg Tyr Pro Val Ser Arg His Ser Trp Val Gly Ala Trp 
            340                 345                 350         


Arg Gly Pro Gln Gly Trp His Trp Ile Asp Glu Ala Pro Leu Pro Pro 
        355                 360                 365             


Gln Leu Leu Pro Glu Asp Gly Glu Asp Asn Leu Asp Ile Asn Cys Gly 
    370                 375                 380                 


Ala Leu Glu Glu Gly Thr Leu Val Ala Ala Asn Cys Ser Thr Pro Arg 
385                 390                 395                 400 


Pro Trp Val Cys Ala Lys Gly Thr Gln 
                405                 


<210>  78
<211>  314
<212>  PRT
<213>  Homo sapiens

<400>  78

Met Glu Glu Ser Trp Glu Ala Ala Pro Gly Gly Gln Ala Gly Ala Glu 
1               5                   10                  15      


Leu Pro Met Glu Pro Val Gly Ser Leu Val Pro Thr Leu Glu Gln Pro 
            20                  25                  30          


Gln Val Pro Ala Lys Val Arg Gln Pro Glu Gly Pro Glu Ser Ser Pro 
        35                  40                  45              


Ser Pro Ala Gly Ala Val Glu Lys Ala Ala Gly Ala Gly Leu Glu Pro 
    50                  55                  60                  


Ser Ser Lys Lys Lys Pro Pro Ser Pro Arg Pro Gly Ser Pro Arg Val 
65                  70                  75                  80  


Pro Pro Leu Ser Leu Gly Tyr Gly Val Cys Pro Glu Pro Pro Ser Pro 
                85                  90                  95      


Gly Pro Ala Leu Val Lys Leu Pro Arg Asn Gly Glu Ala Pro Gly Ala 
            100                 105                 110         


Glu Pro Ala Pro Ser Ala Trp Ala Pro Met Glu Leu Gln Val Asp Val 
        115                 120                 125             


Arg Val Lys Pro Val Gly Ala Ala Gly Gly Ser Ser Thr Pro Ser Pro 
    130                 135                 140                 


Arg Pro Ser Thr Arg Phe Leu Lys Val Pro Val Pro Glu Ser Pro Ala 
145                 150                 155                 160 


Phe Ser Arg His Ala Asp Pro Ala His Gln Leu Leu Leu Arg Ala Pro 
                165                 170                 175     


Ser Gln Gly Gly Thr Trp Gly Arg Arg Ser Pro Leu Ala Ala Ala Arg 
            180                 185                 190         


Thr Glu Ser Gly Cys Asp Ala Glu Gly Arg Ala Ser Pro Ala Glu Gly 
        195                 200                 205             


Ser Ala Gly Ser Pro Gly Ser Pro Thr Cys Cys Arg Cys Lys Glu Leu 
    210                 215                 220                 


Gly Leu Glu Lys Glu Asp Ala Ala Leu Leu Pro Arg Ala Gly Leu Asp 
225                 230                 235                 240 


Gly Asp Glu Lys Leu Pro Arg Ala Val Thr Leu Thr Asp Ser Leu Arg 
                245                 250                 255     


Thr Ala Arg Thr Ile Trp Ile Ser Thr Val Gly Pro Trp Arg Lys Ala 
            260                 265                 270         


Arg Trp Trp Leu Gln Thr Ala Ala Leu Gln Asp Pro Gly Ser Val Pro 
        275                 280                 285             


Arg Gly Pro Ser Asp Leu Gly Ser Ala Trp Ser Ser Ala Cys Gln Ala 
    290                 295                 300                 


Asp Ala Ala Pro Pro Thr Gly Glu Ala Ser 
305                 310                 


<210>  79
<211>  1544
<212>  DNA
<213>  Homo sapiens

<400>  79
gagagcgaag ctcctctgca ctgggcccag gtgcgctcct cagcgtctcc gggtggcggg     60

gcgcgcggga tggaggagtc ttgggaggct gcgcccggag gccaagccgg ggcagagctc    120

ccaatggagc ccgtgggaag cctggtcccc acgctggagc agccgcaggt gcccgcgaag    180

gtgcgacaac ctgaaggtcc cgaaagcagc ccaagtccgg ccggggccgt ggagaaggcg    240

gcgggcgcag gcctggagcc ctcgagcaag aaaaagccgc cttcgcctcg ccccgggtcc    300

ccgcgcgtgc cgccgctcag cctgggctac ggggtctgcc ccgagccgcc gtcaccgggc    360

cctgccttgg tcaagctgcc ccggaatggc gaggcgcccg gggctgagcc tgcgcccagc    420

gcctgggcgc ccatggagct gcaggtagat gtgcgcgtga agcccgtggg cgcggccggt    480

ggcagcagca cgccatcgcc caggccctcc acgcgcttcc tcaaggtgcc ggtgcccgag    540

tcccctgcct tctcccgcca cgcggacccg gcgcaccagc tcctgctgcg cgcaccatcc    600

cagggcggca cgtggggccg ccgctcgccg ctggctgcag cccggacgga gagcggctgc    660

gacgcagagg gccgggccag ccccgcggaa ggaagcgccg gctccccggg ctcccccacg    720

tgctgccgct gcaaggagct ggggctggag aaggaggatg cggcgctgtt gccccgcgcg    780

gggttggacg gcgacgagaa gctgccccgg gccgtaacgc ttacggggct acccatgtac    840

gtgaagtccc tgtactgggc cctggcgttc atggctgtgc tcctggcagt ctctggggtt    900

gtcattgtgg tcctggcctc aagagcagga gccagatgcc agcagtgccc cccaggctgg    960

gtgttgtccg aggagcactg ttactacttc tctgcagaag cgcaggcctg ggaagccagc   1020

caggctttct gctcagccta ccacgctacc ctccccctgc taagccacac ccaggacttc   1080

ctgggcagat acccagtctc caggcactcc tgggtggggg cctggcgagg cccccagggc   1140

tggcactgga tcgacgaggc cccactcccg ccccagctac tccctgagga cggcgaggac   1200

aatctggata tcaactgtgg ggccctggag gaaggcacgc tggtggctgc aaactgcagc   1260

actccaagac cctgggtctg tgccaagggg acccagtgat ctgggctctg cctggtcctc   1320

agcctgccag gcagatgcag caccccctac aggggaggcc agttgagagc ttgggcagcc   1380

tcttcctgga cccagttatc caggtcttca tgctctgctc aagggggcca catgagcgag   1440

cctaggagct ggacttcaac ccaggaagat gcatccgagg gaaaggagat tttctatggc   1500

ctcaggcctg agtgccaata ttagtctcca gcttctgtgg atga                    1544


<210>  80
<211>  1192
<212>  DNA
<213>  Homo sapiens

<400>  80
gagagcgaag ctcctctgca ctgggcccag gtgcgctcct cagcgtctcc gggtggcggg     60

gcgcgcggga tggaggagtc ttgggaggct gcgcccggag gccaagccgg ggcagagctc    120

ccaatggagc ccgtgggaag cctggtcccc acgctggagc agccgcaggt gcccgcgaag    180

gtgcgacaac ctgaaggtcc cgaaagcagc ccaagtccgg ccggggccgt ggagaaggcg    240

gcgggcgcag gcctggagcc ctcgagcaag aaaaagccgc cttcgcctcg ccccgggtcc    300

ccgcgcgtgc cgccgctcag cctgggctac ggggtctgcc ccgagccgcc gtcaccgggc    360

cctgccttgg tcaagctgcc ccggaatggc gaggcgcccg gggctgagcc tgcgcccagc    420

gcctgggcgc ccatggagct gcaggtagat gtgcgcgtga agcccgtggg cgcggccggt    480

ggcagcagca cgccatcgcc caggccctcc acgcgcttcc tcaaggtgcc ggtgcccgag    540

tcccctgcct tctcccgcca cgcggacccg gcgcaccagc tcctgctgcg cgcaccatcc    600

cagggcggca cgtggggccg ccgctcgccg ctggctgcag cccggacgga gagcggctgc    660

gacgcagagg gccgggccag ccccgcggaa ggaagcgccg gctccccggg ctcccccacg    720

tgctgccgct gcaaggagct ggggctggag aaggaggatg cggcgctgtt gccccgcgcg    780

gggttggacg gcgacgagaa gctgccccgg gccgtaacgc ttacggactc cctgaggacg    840

gcgaggacaa tctggatatc aactgtgggg ccctggagga aggcacgctg gtggctgcaa    900

actgcagcac tccaagaccc tgggtctgtg ccaaggggac ccagtgatct gggctctgcc    960

tggtcctcag cctgccaggc agatgcagca ccccctacag gggaggccag ttgagagctt   1020

gggcagcctc ttcctggacc cagttatcca ggtcttcatg ctctgctcaa gggggccaca   1080

tgagcgagcc taggagctgg acttcaaccc aggaagatgc atccgaggga aaggagattt   1140

tctatggcct caggcctgag tgccaatatt agtctccagc ttctgtggat ga           1192


<210>  81
<211>  518
<212>  PRT
<213>  Homo sapiens

<400>  81

Met Leu Ala Ala Ala Ser Lys Tyr Arg His Gly Asn Met Val Phe Phe 
1               5                   10                  15      


Asp Val Leu Gly Leu Phe Val Ile Ala Tyr Pro Ser Arg Ile Gly Ser 
            20                  25                  30          


Ile Ile Asn Tyr Met Val Val Met Gly Val Val Leu Tyr Leu Gly Lys 
        35                  40                  45              


Lys Phe Leu Gln Pro Lys His Lys Thr Gly Asn Tyr Lys Lys Asp Phe 
    50                  55                  60                  


Leu Cys Gly Leu Gly Ile Thr Leu Ile Ser Trp Phe Thr Ser Leu Val 
65                  70                  75                  80  


Thr Val Leu Ile Ile Ala Val Phe Ile Ser Leu Ile Gly Gln Ser Leu 
                85                  90                  95      


Ser Trp Tyr Asn His Phe Tyr Val Ser Val Cys Leu Tyr Gly Thr Ala 
            100                 105                 110         


Thr Val Ala Lys Ile Ile Leu Ile His Thr Leu Ala Lys Arg Phe Tyr 
        115                 120                 125             


Tyr Met Asn Ala Ser Ala Gln Tyr Leu Gly Glu Val Phe Phe Asp Ile 
    130                 135                 140                 


Ser Leu Phe Val His Cys Cys Phe Leu Val Thr Leu Thr Tyr Gln Gly 
145                 150                 155                 160 


Leu Cys Ser Ala Phe Ile Ser Ala Val Trp Val Ala Phe Pro Leu Leu 
                165                 170                 175     


Thr Lys Leu Cys Val His Lys Asp Phe Lys Gln His Gly Ala Gln Gly 
            180                 185                 190         


Lys Phe Ile Ala Phe Tyr Leu Leu Gly Met Phe Ile Pro Tyr Leu Tyr 
        195                 200                 205             


Ala Leu Tyr Leu Ile Trp Ala Val Phe Glu Met Phe Thr Pro Ile Leu 
    210                 215                 220                 


Gly Arg Ser Gly Ser Glu Ile Pro Pro Asp Val Val Leu Ala Ser Ile 
225                 230                 235                 240 


Leu Ala Gly Cys Thr Met Ile Leu Ser Ser Tyr Phe Ile Asn Phe Ile 
                245                 250                 255     


Tyr Leu Ala Lys Ser Thr Lys Lys Thr Met Leu Thr Leu Thr Leu Val 
            260                 265                 270         


Cys Ala Ile Thr Phe Leu Leu Val Cys Ser Gly Thr Phe Phe Pro Tyr 
        275                 280                 285             


Ser Ser Asn Pro Ala Asn Pro Lys Pro Lys Arg Val Phe Leu Gln His 
    290                 295                 300                 


Met Thr Arg Thr Phe His Asp Leu Glu Gly Asn Ala Val Lys Arg Asp 
305                 310                 315                 320 


Ser Gly Ile Trp Ile Asn Gly Phe Asp Tyr Thr Gly Ile Ser His Ile 
                325                 330                 335     


Thr Pro His Ile Pro Glu Ile Asn Asp Ser Ile Arg Ala His Cys Glu 
            340                 345                 350         


Glu Asn Ala Pro Leu Cys Gly Phe Pro Trp Tyr Leu Pro Val His Phe 
        355                 360                 365             


Leu Ile Arg Lys Asn Trp Tyr Leu Pro Ala Pro Glu Val Ser Pro Arg 
    370                 375                 380                 


Asn Pro Pro His Phe Arg Leu Ile Ser Lys Glu Gln Thr Pro Trp Asp 
385                 390                 395                 400 


Ser Ile Lys Leu Thr Phe Glu Ala Thr Gly Pro Ser His Met Ser Phe 
                405                 410                 415     


Tyr Val Arg Ala His Lys Gly Ser Thr Leu Ser Gln Trp Ser Leu Gly 
            420                 425                 430         


Asn Gly Thr Pro Val Thr Ser Lys Gly Gly Asp Tyr Phe Val Phe Tyr 
        435                 440                 445             


Ser His Gly Leu Gln Ala Ser Ala Trp Gln Phe Trp Ile Glu Val Gln 
    450                 455                 460                 


Val Ser Glu Glu His Pro Glu Gly Met Val Thr Val Ala Ile Ala Ala 
465                 470                 475                 480 


His Tyr Leu Ser Gly Glu Asp Lys Arg Ser Pro Gln Leu Asp Ala Leu 
                485                 490                 495     


Lys Glu Lys Phe Pro Asp Trp Thr Phe Pro Ser Ala Trp Val Cys Thr 
            500                 505                 510         


Tyr Asp Leu Phe Val Phe 
        515             


<210>  82
<211>  904
<212>  PRT
<213>  Homo sapiens

<400>  82

Met Glu Trp Gly Ser Glu Ser Ala Ala Val Arg Arg His Arg Val Gly 
1               5                   10                  15      


Val Glu Arg Arg Glu Gly Ala Ala Ala Ala Pro Pro Pro Glu Arg Glu 
            20                  25                  30          


Ala Arg Ala Gln Glu Pro Leu Val Asp Gly Cys Ser Gly Gly Gly Arg 
        35                  40                  45              


Thr Arg Lys Arg Ser Pro Gly Gly Ser Gly Gly Ala Ser Arg Gly Ala 
    50                  55                  60                  


Gly Thr Gly Leu Ser Glu Val Arg Ala Ala Leu Gly Leu Ala Leu Tyr 
65                  70                  75                  80  


Leu Ile Ala Leu Arg Thr Leu Val Gln Leu Ser Leu Gln Gln Leu Val 
                85                  90                  95      


Leu Arg Gly Ala Ala Gly His Arg Gly Glu Phe Asp Ala Leu Gln Ala 
            100                 105                 110         


Arg Asp Tyr Leu Glu His Ile Thr Ser Ile Gly Pro Arg Thr Thr Gly 
        115                 120                 125             


Ser Pro Glu Asn Glu Ile Leu Thr Val His Tyr Leu Leu Glu Gln Ile 
    130                 135                 140                 


Lys Leu Ile Glu Val Gln Ser Asn Ser Leu His Lys Ile Ser Val Asp 
145                 150                 155                 160 


Val Gln Arg Pro Thr Gly Ser Phe Ser Ile Asp Phe Leu Gly Gly Phe 
                165                 170                 175     


Thr Ser Tyr Tyr Asp Asn Ile Thr Asn Val Val Val Lys Leu Glu Pro 
            180                 185                 190         


Arg Asp Gly Ala Gln His Ala Val Leu Ala Asn Cys His Phe Asp Ser 
        195                 200                 205             


Val Ala Asn Ser Pro Gly Ala Ser Asp Asp Ala Val Ser Cys Ser Val 
    210                 215                 220                 


Met Leu Glu Val Leu Arg Val Leu Ser Thr Ser Ser Glu Ala Leu His 
225                 230                 235                 240 


His Ala Val Ile Phe Leu Phe Asn Gly Ala Glu Glu Asn Val Leu Gln 
                245                 250                 255     


Ala Ser His Gly Phe Ile Thr Gln His Pro Trp Ala Ser Leu Ile Arg 
            260                 265                 270         


Ala Phe Ile Asn Leu Glu Ala Ala Gly Val Gly Gly Lys Glu Leu Val 
        275                 280                 285             


Phe Gln Thr Gly Pro Glu Asn Pro Trp Leu Val Gln Ala Tyr Val Ser 
    290                 295                 300                 


Ala Ala Lys His Pro Phe Ala Ser Val Val Ala Gln Glu Val Phe Gln 
305                 310                 315                 320 


Ser Gly Ile Ile Pro Ser Asp Thr Asp Phe Arg Ile Tyr Arg Asp Phe 
                325                 330                 335     


Gly Asn Ile Pro Gly Ile Asp Leu Ala Phe Ile Glu Asn Gly Tyr Ile 
            340                 345                 350         


Tyr His Thr Lys Tyr Asp Thr Ala Asp Arg Ile Leu Thr Asp Ser Ile 
        355                 360                 365             


Gln Arg Ala Gly Asp Asn Ile Leu Ala Val Leu Lys His Leu Ala Thr 
    370                 375                 380                 


Ser Asp Met Leu Ala Ala Ala Ser Lys Tyr Arg His Gly Asn Met Val 
385                 390                 395                 400 


Phe Phe Asp Val Leu Gly Leu Phe Val Ile Ala Tyr Pro Ser Arg Ile 
                405                 410                 415     


Gly Ser Ile Ile Asn Tyr Met Val Val Met Gly Val Val Leu Tyr Leu 
            420                 425                 430         


Gly Lys Lys Phe Leu Gln Pro Lys His Lys Thr Gly Asn Tyr Lys Lys 
        435                 440                 445             


Asp Phe Leu Cys Gly Leu Gly Ile Thr Leu Ile Ser Trp Phe Thr Ser 
    450                 455                 460                 


Leu Val Thr Val Leu Ile Ile Ala Val Phe Ile Ser Leu Ile Gly Gln 
465                 470                 475                 480 


Ser Leu Ser Trp Tyr Asn His Phe Tyr Val Ser Val Cys Leu Tyr Gly 
                485                 490                 495     


Thr Ala Thr Val Ala Lys Ile Ile Leu Ile His Thr Leu Ala Lys Arg 
            500                 505                 510         


Phe Tyr Tyr Met Asn Ala Ser Ala Gln Tyr Leu Gly Glu Val Phe Phe 
        515                 520                 525             


Asp Ile Ser Leu Phe Val His Cys Cys Phe Leu Val Thr Leu Thr Tyr 
    530                 535                 540                 


Gln Gly Leu Cys Ser Ala Phe Ile Ser Ala Val Trp Val Ala Phe Pro 
545                 550                 555                 560 


Leu Leu Thr Lys Leu Cys Val His Lys Asp Phe Lys Gln His Gly Ala 
                565                 570                 575     


Gln Gly Lys Phe Ile Ala Phe Tyr Leu Leu Gly Met Phe Ile Pro Tyr 
            580                 585                 590         


Leu Tyr Ala Leu Tyr Leu Ile Trp Ala Val Phe Glu Met Phe Thr Pro 
        595                 600                 605             


Ile Leu Gly Arg Ser Gly Ser Glu Ile Pro Pro Asp Val Val Leu Ala 
    610                 615                 620                 


Ser Ile Leu Ala Gly Cys Thr Met Ile Leu Ser Ser Tyr Phe Ile Asn 
625                 630                 635                 640 


Phe Ile Tyr Leu Ala Lys Ser Thr Lys Lys Thr Met Leu Thr Leu Thr 
                645                 650                 655     


Leu Val Cys Ala Ile Thr Phe Leu Leu Val Cys Ser Gly Thr Phe Phe 
            660                 665                 670         


Pro Tyr Ser Ser Asn Pro Ala Asn Pro Lys Pro Lys Arg Val Phe Leu 
        675                 680                 685             


Gln His Met Thr Arg Thr Phe His Asp Leu Glu Gly Asn Ala Val Lys 
    690                 695                 700                 


Arg Asp Ser Gly Ile Trp Ile Asn Gly Phe Asp Tyr Thr Gly Ile Ser 
705                 710                 715                 720 


His Ile Thr Pro His Ile Pro Glu Ile Asn Asp Ser Ile Arg Ala His 
                725                 730                 735     


Cys Glu Glu Asn Ala Pro Leu Cys Gly Phe Pro Trp Tyr Leu Pro Val 
            740                 745                 750         


His Phe Leu Ile Arg Lys Asn Trp Tyr Leu Pro Ala Pro Glu Val Ser 
        755                 760                 765             


Pro Arg Asn Pro Pro His Phe Arg Leu Ile Ser Lys Glu Gln Thr Pro 
    770                 775                 780                 


Trp Asp Ser Ile Lys Leu Thr Phe Glu Ala Thr Gly Pro Ser His Met 
785                 790                 795                 800 


Ser Phe Tyr Val Arg Ala His Lys Gly Ser Thr Leu Ser Gln Trp Ser 
                805                 810                 815     


Leu Gly Asn Gly Thr Pro Val Thr Ser Lys Gly Gly Asp Tyr Phe Val 
            820                 825                 830         


Phe Tyr Ser His Gly Leu Gln Ala Ser Ala Trp Gln Phe Trp Ile Glu 
        835                 840                 845             


Val Gln Val Ser Glu Glu His Pro Glu Gly Met Val Thr Val Ala Ile 
    850                 855                 860                 


Ala Ala His Tyr Leu Ser Gly Glu Asp Lys Arg Ser Pro Gln Leu Asp 
865                 870                 875                 880 


Ala Leu Lys Glu Lys Phe Pro Asp Trp Thr Phe Pro Ser Ala Trp Val 
                885                 890                 895     


Cys Thr Tyr Asp Leu Phe Val Phe 
            900                 


<210>  83
<211>  419
<212>  PRT
<213>  Homo sapiens

<400>  83

Met Val Val Met Gly Val Val Leu Tyr Leu Gly Lys Lys Phe Leu Gln 
1               5                   10                  15      


Pro Lys His Lys Thr Gly Asn Tyr Lys Lys Asp Phe Leu Cys Gly Leu 
            20                  25                  30          


Gly Ile Thr Leu Ile Ser Trp Phe Thr Ser Leu Val Thr Val Leu Ile 
        35                  40                  45              


Ile Ala Val Phe Ile Ser Leu Ile Gly Gln Ser Leu Ser Trp Tyr Asn 
    50                  55                  60                  


His Phe Tyr Val Ser Val Cys Leu Tyr Gly Thr Ala Thr Val Ala Lys 
65                  70                  75                  80  


Ile Ile Leu Ile His Thr Leu Ala Lys Arg Phe Tyr Tyr Met Asn Ala 
                85                  90                  95      


Ser Ala Gln Tyr Leu Gly Glu Val Phe Phe Asp Ile Ser Leu Phe Val 
            100                 105                 110         


His Cys Cys Phe Leu Val Thr Leu Thr Tyr Gln Gly Leu Cys Ser Ala 
        115                 120                 125             


Phe Ile Ser Ala Val Trp Val Ala Phe Pro Leu Leu Thr Lys Leu Cys 
    130                 135                 140                 


Val His Lys Asp Phe Lys Gln His Gly Ala Gln Gly Lys Phe Ile Ala 
145                 150                 155                 160 


Phe Tyr Leu Leu Gly Met Phe Ile Pro Tyr Leu Tyr Ala Leu Tyr Leu 
                165                 170                 175     


Ile Trp Ala Val Phe Glu Met Phe Thr Pro Ile Leu Gly Arg Ser Gly 
            180                 185                 190         


Ser Glu Ile Pro Pro Asp Val Val Leu Ala Ser Ile Leu Ala Gly Cys 
        195                 200                 205             


Thr Met Ile Leu Ser Ser Tyr Phe Ile Asn Phe Ile Tyr Leu Ala Lys 
    210                 215                 220                 


Ser Thr Lys Lys Thr Met Leu Thr Leu Thr Leu Val Cys Ala Ile Thr 
225                 230                 235                 240 


Phe Leu Leu Val Cys Ser Gly Thr Phe Phe Pro Tyr Ser Ser Asn Pro 
                245                 250                 255     


Ala Asn Pro Lys Pro Lys Arg Val Phe Leu Gln His Met Thr Arg Thr 
            260                 265                 270         


Phe His Asp Leu Glu Gly Asn Ala Val Lys Arg Asp Ser Gly Ile Trp 
        275                 280                 285             


Ile Asn Gly Phe Asp Tyr Thr Gly Ile Ser His Ile Thr Pro His Ile 
    290                 295                 300                 


Pro Glu Ile Asn Asp Ser Ile Arg Ala His Cys Glu Glu Asn Ala Pro 
305                 310                 315                 320 


Leu Cys Gly Phe Pro Trp Tyr Leu Pro Val His Phe Leu Ile Arg Lys 
                325                 330                 335     


Asn Trp Tyr Leu Pro Ala Pro Glu Val Ser Pro Arg Asn Pro Pro His 
            340                 345                 350         


Phe Arg Leu Ile Ser Lys Glu Gln Thr Pro Trp Asp Ser Ile Lys Leu 
        355                 360                 365             


Thr Phe Glu Ala Thr Ala Cys Leu Pro Ile Leu Gln Ile Leu Asp Leu 
    370                 375                 380                 


Pro Ala Ser Thr Ile Met Thr Lys Pro Tyr Val Leu Leu Cys Ser Ser 
385                 390                 395                 400 


Pro Gln Arg Val Asn Thr Phe Ser Val Val Ser Trp Gln Trp His Pro 
                405                 410                 415     


Ser His Lys 
            


<210>  84
<211>  4974
<212>  DNA
<213>  Homo sapiens

<400>  84
ggcgcgggga ccgggctgtc tgaggtgcgc gccgcgctgg ggctcgcgct ctacctgatc     60

gcgctgcgga cgctggtgca gctctcgctg cagcagctcg tgctacgcgg ggccgctgga    120

caccgcgggg agttcgacgc gctccaagcc agggattatc ttgaacacat aacctccatt    180

ggccccagga ctacaggaag tccagaaaat gaaattctga ccgtgcacta ccttttggaa    240

cagattaaac tgattgaagt gcaaagcaac agccttcata agatttcagt agatgtacaa    300

cggcccacag gctcttttag cattgatttc ttgggaggtt ttacaagcta ttatgacaac    360

atcaccaatg ttgtggtaaa gctggaaccc agagatggag cccagcatgc tgtcttggct    420

aattgtcatt ttgactcagt agcaaactca ccaggccagt catggtttca ttactcagca    480

cccctgggct agcttgattc gtgcattcat taacctagag gcagcaggtg taggagggaa    540

agaacttgta ttccaaacag gtcctgaaaa tccttggttg gttcaagctt atgtttcagc    600

agctaaacac ccttttgctt ctgtggtggc tcaggaggtt tttcagagtg gaatcattcc    660

ttcagatact gactttcgta tctacaggga ttttgggaac attccaggaa tagacttagc    720

ttttattgag aatggataca tttatcacac caagtatgac acagcggaca gaattctaac    780

agattccatt cagagagcag gtgacaacat tttagcagtt cttaagcatc tagctacatc    840

tgatatgctg gctgctgctt ctaagtatcg acatggaaac atggtcttct ttgatgtgct    900

gggcctgttt gtcattgcct acccctctcg tattggctca atcataaact acatggtggt    960

aatgggtgtt gttttgtacc tgggcaaaaa atttttgcag cccaaacata agactggtaa   1020

ctacaagaag gacttcttgt gtggacttgg catcactttg atcagctggt tcactagcct   1080

tgttaccgtt ctcattatag cagtgttcat ctctcttatt ggacagtctc tctcatggta   1140

taaccacttc tatgtctccg tttgtctgta tggaactgca actgtagcca aaataatact   1200

tatacatact cttgcgaaaa gattttatta catgaatgcc agtgcccagt atctgggaga   1260

agtatttttt gacatttcgc tgtttgtcca ttgctgtttt cttgttaccc tcacttacca   1320

aggactttgc tcggcgttta ttagtgctgt ctgggtagca ttcccattgc tcacaaagct   1380

ctgtgtgcat aaggacttca agcagcatgg tgcccaagga aaatttattg ctttttacct   1440

tttggggatg tttattcctt atctttatgc attgtacctc atctgggcag tatttgagat   1500

gtttacccct atcctcggga gaagtggttc tgaaatccca cctgatgttg tgctggcatc   1560

cattttggct ggctgtacaa tgattctctc gtcctatttt attaacttca tctaccttgc   1620

caagagcaca aaaaaaacca tgctaacttt aactttggta tgtgcaatta cattcctcct   1680

tgtttgcagt ggaacatttt ttccatatag ctccaatcct gctaatccga agccaaagag   1740

agtgtttctt cagcatatga ctagaacatt ccatgacttg gaaggaaatg cagttaaacg   1800

ggactctgga atatggatca atgggtttga ttatactgga atttctcaca taacccctca   1860

cattcctgag atcaatgata gtatccgagc tcactgtgag gagaatgcac ctctttgtgg   1920

ttttccttgg tatcttccag tgcactttct gatcaggaaa aactggtatc ttcctgcccc   1980

agaagtttct ccaagaaatc ctcctcattt ccgactcata tccaaagaac agacaccttg   2040

ggattctata aaattgactt ttgaagcaac aggaccaagc catatgtcct tctatgttcg   2100

agcccacaaa gggtcaacac tttctcagtg gtctcttggc aatggcaccc cagtcacaag   2160

taaaggagga gactactttg tcttttactc ccatggactc caggcctctg catggcagtt   2220

ctggatagaa gtgcaggttt cagaagaaca tcctgaagga atggtcaccg tggccattgc   2280

tgcccactat ctgtctgggg aagacaagag atcccctcaa ctggatgctc tgaaggaaaa   2340

gttcccagat tggacatttc cctctgcctg ggtgtgcacc tacgatctct ttgtatttta   2400

atcttgtgga tgagctctaa gtacatgccc agtggatact ccatgtgaca tggtttctcc   2460

ctatgttacg tggatgtttg taacgtaagt caatgaattt taatgatcat atgttcaaag   2520

agctttctgg gttaacgctt ttcagggcca agcactataa gggtttagct gtggcgcagt   2580

gatgcatggc ctgttgacac ttgaaaatgc cagtcttttg gcacttcagc acatgtgggt   2640

actgccacta cacacacgtc attttatatg accttaagga caaagccaac aatccacttc   2700

aatagctgcc cctttaggat caagaaagat gtacactgtc agagcattgt taatgagaca   2760

aaagttgttt ccaatttaag ccccaaaacc atttgttgta ttagtggatg gtgggtaaaa   2820

tatcattcac tgaggtaatg attccccttg agaatataac tctgtgtagg tcactggaaa   2880

gtgattgcca tagggctggg agagaagcat tgcactcttg aggctgtagc ctgtgtcaag   2940

ctgtttcttc aggcagcctc tcaaatgtgc tttgtctctc tgtgctgagg cctggaccct   3000

gtgctgagct ggtgactcac tgtcctgaca agtggacaca cagatgcact gctgtgctgc   3060

tttcctgagg tggttttcta tgcctgtttt cctctgaaac atgtctgtta cccctctcca   3120

tcttaccaag ttgaaaaggg gaatatttgg ccacataccc ctctggtttt cgtaggttct   3180

tttggttcag aatattgttt gtgccagtac atgaccttaa cttccttcct cagagcactg   3240

agctgccatc tgggctattc tggggtagaa ggaaggctgg gagtggtggg aattttataa   3300

atatttattc tcttttcttt gtttcatagg agtcttgtgt tatacaaggt tagtccttca   3360

tggtataatc ttactgatgc actgggccta tctttttgtt ttccagccag ttgaatagat   3420

tagtttttct cagtaactta ctatccagca gactggcttt cctgagactt gaggttgtgg   3480

cttatactgg aatgagacca ctgtacgtgt aggtggttca gatcctgcgt aatggcagca   3540

tgaggactta aaaggtggtt ttcattttga agatggctat gtagcttgta aggtgtatca   3600

cagcagtacc tctcatggct ttttggttcc agcagtgagg gcattggtga gatcaatggt   3660

aaactgtgca agctttcttt ttatcattag gaaatgtgaa acgttggaca aattttgagt   3720

tttaacaagg acaaaaagtt gaaagaaaag gcacagttaa caaaaaaggg tggctagatt   3780

tatcttgggt gatggaggaa atgagagagg aatgctcttg aaaggtggtc tgtggatctg   3840

tctgaataga aagagcacag taagtatgca ttgccggaga aaacgtcctt gaagctgctt   3900

gtctcatgtg tatgatgtgc tttttaaatc atgcccctcg ttgcctgcct aatctgtgac   3960

tccctaaaaa ctaactgggc ccatgtagat ggggctgcaa ccagagctga ataacatgtt   4020

aggctcacac atgcatcagc actgcacact ggaatcattg ctcttcctgg actttgtaga   4080

aatcagtctc aagtgcttca agagtctggc tcctgctact tttatctgtc aggtagcaca   4140

taaggtttgc agggtttata ttttgtatag aatcacagtt gtggagaaaa agtaataatt   4200

tctcaatgaa ttttaaaaat gggcctattt tctatccccg tggttcatct gatataatta   4260

gtgttccctg tgaattcccc ccctctatgg gaaggatgcc tttactcttt atcagtaata   4320

aattatgact gttttcatat tgccttaggg ttatttccct gtgtaaacca ttgtcttttg   4380

ttttggtttt ctttagcatt atgaagcttt ggtattgtac aaggtcagta gtaagatgct   4440

cactagtctc agggcttgtg taatattctg ggaggtcatt taaatgccag aaatggtcaa   4500

gcaattatac acagtattta tgactctgtt aagcataccg tttgtctgtc acattagtag   4560

attctgagat taaaaaaaat ttttaaagag tgatcattta aataatttct aaaagggtct   4620

tttcaagctc taacaaagtc actaacaaat gcattatttt ctacagaatt agatgttagt   4680

agtacagtac tgcatattca gggaaaaagt gtgaggaatt gatttcaaaa tagttcgttc   4740

ttgtgtttga cctaagaatg attgtcgcat gaagtgtttg tttttacagt ttagcatata   4800

taaacaaaca tgataggatt ccttaagatg ttaccaccca gggggccaca agccagcctg   4860

ctgtctcagg aagctgtaga aggagtgttt gtcaatttct tgtcactggt ttgctgactt   4920

actgaggatt aattgttgcc ttacaatgtt actgaaataa actgtttaat atac         4974


<210>  85
<211>  5338
<212>  DNA
<213>  Homo sapiens

<400>  85
ggccggggct gtcgcgggtt ggggcggttg ggctggcagc tgaggctcgt ggccatggag     60

tggggttctg agtcggctgc tgtgaggcgg caccgcgtcg gagtagagcg tcgagaggga    120

gcggcggccg cgccaccgcc ggagagggag gcccgagcgc aggagcctct ggtggatggg    180

tgcagcggcg gcgggaggac gcggaagagg agccccgggg gtagcggcgg cgcgagcagg    240

ggcgcgggga ccgggctgtc tgaggtgcgc gccgcgctgg ggctcgcgct ctacctgatc    300

gcgctgcgga cgctggtgca gctctcgctg cagcagctcg tgctacgcgg ggccgctgga    360

caccgcgggg agttcgacgc gctccaagcc agggattatc ttgaacacat aacctccatt    420

ggccccagga ctacaggaag tccagaaaat gaaattctga ccgtgcacta ccttttggaa    480

cagattaaac tgattgaagt gcaaagcaac agccttcata agatttcagt agatgtacaa    540

cggcccacag gctcttttag cattgatttc ttgggaggtt ttacaagcta ttatgacaac    600

atcaccaatg ttgtggtaaa gctggaaccc agagatggag cccagcatgc tgtcttggct    660

aattgtcatt ttgactcagt agcaaactca ccaggtgcca gtgatgatgc agttagctgc    720

tcagtgatgc tggaagtcct tcgcgtcttg tcaacatctt cagaagcctt gcatcatgct    780

gtcatatttc tctttaatgg tgctgaggaa aatgtcttgc aagccagtca tggtttcatt    840

actcagcacc cctgggctag cttgattcgt gcattcatta acctagaggc agcaggtgta    900

ggagggaaag aacttgtatt ccaaacaggt cctgaaaatc cttggttggt tcaagcttat    960

gtttcagcag ctaaacaccc ttttgcttct gtggtggctc aggaggtttt tcagagtgga   1020

atcattcctt cagatactga ctttcgtatc tacagggatt ttgggaacat tccaggaata   1080

gacttagctt ttattgagaa tggatacatt tatcacacca agtatgacac agcggacaga   1140

attctaacag attccattca gagagcaggt gacaacattt tagcagttct taagcatcta   1200

gctacatctg atatgctggc tgctgcttct aagtatcgac atggaaacat ggtcttcttt   1260

gatgtgctgg gcctgtttgt cattgcctac ccctctcgta ttggctcaat cataaactac   1320

atggtggtaa tgggtgttgt tttgtacctg ggcaaaaaat ttttgcagcc caaacataag   1380

actggtaact acaagaagga cttcttgtgt ggacttggca tcactttgat cagctggttc   1440

actagccttg ttaccgttct cattatagca gtgttcatct ctcttattgg acagtctctc   1500

tcatggtata accacttcta tgtctccgtt tgtctgtatg gaactgcaac tgtagccaaa   1560

ataatactta tacatactct tgcgaaaaga ttttattaca tgaatgccag tgcccagtat   1620

ctgggagaag tattttttga catttcgctg tttgtccatt gctgttttct tgttaccctc   1680

acttaccaag gactttgctc ggcgtttatt agtgctgtct gggtagcatt cccattgctc   1740

acaaagctct gtgtgcataa ggacttcaag cagcatggtg cccaaggaaa atttattgct   1800

ttttaccttt tggggatgtt tattccttat ctttatgcat tgtacctcat ctgggcagta   1860

tttgagatgt ttacccctat cctcgggaga agtggttctg aaatcccacc tgatgttgtg   1920

ctggcatcca ttttggctgg ctgtacaatg attctctcgt cctattttat taacttcatc   1980

taccttgcca agagcacaaa aaaaaccatg ctaactttaa ctttggtatg tgcaattaca   2040

ttcctccttg tttgcagtgg aacatttttt ccatatagct ccaatcctgc taatccgaag   2100

ccaaagagag tgtttcttca gcatatgact agaacattcc atgacttgga aggaaatgca   2160

gttaaacggg actctggaat atggatcaat gggtttgatt atactggaat ttctcacata   2220

acccctcaca ttcctgagat caatgatagt atccgagctc actgtgagga gaatgcacct   2280

ctttgtggtt ttccttggta tcttccagtg cactttctga tcaggaaaaa ctggtatctt   2340

cctgccccag aagtttctcc aagaaatcct cctcatttcc gactcatatc caaagaacag   2400

acaccttggg attctataaa attgactttt gaagcaacag gaccaagcca tatgtccttc   2460

tatgttcgag cccacaaagg gtcaacactt tctcagtggt ctcttggcaa tggcacccca   2520

gtcacaagta aaggaggaga ctactttgtc ttttactccc atggactcca ggcctctgca   2580

tggcagttct ggatagaagt gcaggtttca gaagaacatc ctgaaggaat ggtcaccgtg   2640

gccattgctg cccactatct gtctggggaa gacaagagat cccctcaact ggatgctctg   2700

aaggaaaagt tcccagattg gacatttccc tctgcctggg tgtgcaccta cgatctcttt   2760

gtattttaat cttgtggatg agctctaagt acatgcccag tggatactcc atgtgacatg   2820

gtttctccct atgttacgtg gatgtttgta acgtaagtca atgaatttta atgatcatat   2880

gttcaaagag ctttctgggt taacgctttt cagggccaag cactataagg gtttagctgt   2940

ggcgcagtga tgcatggcct gttgacactt gaaaatgcca gtcttttggc acttcagcac   3000

atgtgggtac tgccactaca cacacgtcat tttatatgac cttaaggaca aagccaacaa   3060

tccacttcaa tagctgcccc tttaggatca agaaagatgt acactgtcag agcattgtta   3120

atgagacaaa agttgtttcc aatttaagcc ccaaaaccat ttgttgtatt agtggatggt   3180

gggtaaaata tcattcactg aggtaatgat tccccttgag aatataactc tgtgtaggtc   3240

actggaaagt gattgccata gggctgggag agaagcattg cactcttgag gctgtagcct   3300

gtgtcaagct gtttcttcag gcagcctctc aaatgtgctt tgtctctctg tgctgaggcc   3360

tggaccctgt gctgagctgg tgactcactg tcctgacaag tggacacaca gatgcactgc   3420

tgtgctgctt tcctgaggtg gttttctatg cctgttttcc tctgaaacat gtctgttacc   3480

cctctccatc ttaccaagtt gaaaagggga atatttggcc acatacccct ctggttttcg   3540

taggttcttt tggttcagaa tattgtttgt gccagtacat gaccttaact tccttcctca   3600

gagcactgag ctgccatctg ggctattctg gggtagaagg aaggctggga gtggtgggaa   3660

ttttataaat atttattctc ttttctttgt ttcataggag tcttgtgtta tacaaggtta   3720

gtccttcatg gtataatctt actgatgcac tgggcctatc tttttgtttt ccagccagtt   3780

gaatagatta gtttttctca gtaacttact atccagcaga ctggctttcc tgagacttga   3840

ggttgtggct tatactggaa tgagaccact gtacgtgtag gtggttcaga tcctgcgtaa   3900

tggcagcatg aggacttaaa aggtggtttt cattttgaag atggctatgt agcttgtaag   3960

gtgtatcaca gcagtacctc tcatggcttt ttggttccag cagtgagggc attggtgaga   4020

tcaatggtaa actgtgcaag ctttcttttt atcattagga aatgtgaaac gttggacaaa   4080

ttttgagttt taacaaggac aaaaagttga aagaaaaggc acagttaaca aaaaagggtg   4140

gctagattta tcttgggtga tggaggaaat gagagaggaa tgctcttgaa aggtggtctg   4200

tggatctgtc tgaatagaaa gagcacagta agtatgcatt gccggagaaa acgtccttga   4260

agctgcttgt ctcatgtgta tgatgtgctt tttaaatcat gcccctcgtt gcctgcctaa   4320

tctgtgactc cctaaaaact aactgggccc atgtagatgg ggctgcaacc agagctgaat   4380

aacatgttag gctcacacat gcatcagcac tgcacactgg aatcattgct cttcctggac   4440

tttgtagaaa tcagtctcaa gtgcttcaag agtctggctc ctgctacttt tatctgtcag   4500

gtagcacata aggtttgcag ggtttatatt ttgtatagaa tcacagttgt ggagaaaaag   4560

taataatttc tcaatgaatt ttaaaaatgg gcctattttc tatccccgtg gttcatctga   4620

tataattagt gttccctgtg aattcccccc ctctatggga aggatgcctt tactctttat   4680

cagtaataaa ttatgactgt tttcatattg ccttagggtt atttccctgt gtaaaccatt   4740

gtcttttgtt ttggttttct ttagcattat gaagctttgg tattgtacaa ggtcagtagt   4800

aagatgctca ctagtctcag ggcttgtgta atattctggg aggtcattta aatgccagaa   4860

atggtcaagc aattatacac agtatttatg actctgttaa gcataccgtt tgtctgtcac   4920

attagtagat tctgagatta aaaaaaattt ttaaagagtg atcatttaaa taatttctaa   4980

aagggtcttt tcaagctcta acaaagtcac taacaaatgc attattttct acagaattag   5040

atgttagtag tacagtactg catattcagg gaaaaagtgt gaggaattga tttcaaaata   5100

gttcgttctt gtgtttgacc taagaatgat tgtcgcatga agtgtttgtt tttacagttt   5160

agcatatata aacaaacatg ataggattcc ttaagatgtt accacccagg gggccacaag   5220

ccagcctgct gtctcaggaa gctgtagaag gagtgtttgt caatttcttg tcactggttt   5280

gctgacttac tgaggattaa ttgttgcctt acaatgttac tgaaataaac tgtttaat     5338


<210>  86
<211>  5387
<212>  DNA
<213>  Homo sapiens

<400>  86
ggccggggct gtcgcgggtt ggggcggttg ggctggcagc tgaggctcgt ggccatggag     60

tggggttctg agtcggctgc tgtgaggcgg caccgcgtcg gagtagagcg tcgagaggga    120

gcggcggccg cgccaccgcc ggagagggag gcccgagcgc aggagcctct ggtggatggg    180

tgcagcggcg gcgggaggac gcggaagagg agccccgggg gtagcggcgg cgcgagcagg    240

ggcgcgggga ccgggctgtc tgaggtgcgc gccgcgctgg ggctcgcgct ctacctgatc    300

gcgctgcgga cgctggtgca gctctcgctg cagcagctcg tgctacgcgg ggccgctgga    360

caccgcgggg agttcgacgc gctccaagcc agggattatc ttgaacacat aacctccatt    420

ggccccagga ctacaggaag tccagaaaat gaaattctga ccgtgcacta ccttttggaa    480

cagattaaac tgattgaagt gcaaagcaac agccttcata agatttcagt agatgtacaa    540

cggcccacag gctcttttag cattgatttc ttgggaggtt ttacaagcta ttatgacaac    600

atcaccaatg ttgtggtaaa gctggaaccc agagatggag cccagcatgc tgtcttggct    660

aattgtcatt ttgactcagt agcaaactca ccaggtgcca gtgatgatgc agttagctgc    720

tcagtgatgc tggaagtcct tcgcgtcttg tcaacatctt cagaagcctt gcatcatgct    780

gtcatatttc tctttaatgg tgctgaggaa aatgtcttgc aagccagtca tggtttcatt    840

actcagcacc cctgggctag cttgattcgt gcattcatta acctagaggc agcaggtgta    900

ggagggaaag aacttgtatt ccaaacaggt cctgaaaatc cttggttggt tcaagcttat    960

gtttcagcag ctaaacaccc ttttgcttct gtggtggctc aggaggtttt tcagagtgga   1020

atcattcctt cagatactga ctttcgtatc tacagggatt ttgggaacat tccaggaata   1080

gacttagctt ttattgagaa tggatacatt tatcacacca agtatgacac agcggacaga   1140

attctaacag attccattca gagagcaggt gacaacattt tagcagttct taagcatcta   1200

gctacatctg atatgctggc tgctgcttct aagtatcgac atggaaacat ggtcttcttt   1260

gatgtgctgg gcctgtttgt cattgcctac ccctctcgta ttggctcaat cataaactac   1320

atggtggtaa tgggtgttgt tttgtacctg ggcaaaaaat ttttgcagcc caaacataag   1380

actggtaact acaagaagga cttcttgtgt ggacttggca tcactttgat cagctggttc   1440

actagccttg ttaccgttct cattatagca gtgttcatct ctcttattgg acagtctctc   1500

tcatggtata accacttcta tgtctccgtt tgtctgtatg gaactgcaac tgtagccaaa   1560

ataatactta tacatactct tgcgaaaaga ttttattaca tgaatgccag tgcccagtat   1620

ctgggagaag tattttttga catttcgctg tttgtccatt gctgttttct tgttaccctc   1680

acttaccaag gactttgctc ggcgtttatt agtgctgtct gggtagcatt cccattgctc   1740

acaaagctct gtgtgcataa ggacttcaag cagcatggtg cccaaggaaa atttattgct   1800

ttttaccttt tggggatgtt tattccttat ctttatgcat tgtacctcat ctgggcagta   1860

tttgagatgt ttacccctat cctcgggaga agtggttctg aaatcccacc tgatgttgtg   1920

ctggcatcca ttttggctgg ctgtacaatg attctctcgt cctattttat taacttcatc   1980

taccttgcca agagcacaaa aaaaaccatg ctaactttaa ctttggtatg tgcaattaca   2040

ttcctccttg tttgcagtgg aacatttttt ccatatagct ccaatcctgc taatccgaag   2100

ccaaagagag tgtttcttca gcatatgact agaacattcc atgacttgga aggaaatgca   2160

gttaaacggg actctggaat atggatcaat gggtttgatt atactggaat ttctcacata   2220

acccctcaca ttcctgagat caatgatagt atccgagctc actgtgagga gaatgcacct   2280

ctttgtggtt ttccttggta tcttccagtg cactttctga tcaggaaaaa ctggtatctt   2340

cctgccccag aagtttctcc aagaaatcct cctcatttcc gactcatatc caaagaacag   2400

acaccttggg attctataaa attgactttt gaagcaacag cctgcctgcc tatccttcag   2460

attttggact tgccagcctc aacaatcatg accaagccat atgtccttct atgttcgagc   2520

ccacaaaggg tcaacacttt ctcagtggtc tcttggcaat ggcaccccag tcacaagtaa   2580

aggaggagac tactttgtct tttactccca tggactccag gcctctgcat ggcagttctg   2640

gatagaagtg caggtttcag aagaacatcc tgaaggaatg gtcaccgtgg ccattgctgc   2700

ccactatctg tctggggaag acaagagatc ccctcaactg gatgctctga aggaaaagtt   2760

cccagattgg acatttccct ctgcctgggt gtgcacctac gatctctttg tattttaatc   2820

ttgtggatga gctctaagta catgcccagt ggatactcca tgtgacatgg tttctcccta   2880

tgttacgtgg atgtttgtaa cgtaagtcaa tgaattttaa tgatcatatg ttcaaagagc   2940

tttctgggtt aacgcttttc agggccaagc actataaggg tttagctgtg gcgcagtgat   3000

gcatggcctg ttgacacttg aaaatgccag tcttttggca cttcagcaca tgtgggtact   3060

gccactacac acacgtcatt ttatatgacc ttaaggacaa agccaacaat ccacttcaat   3120

agctgcccct ttaggatcaa gaaagatgta cactgtcaga gcattgttaa tgagacaaaa   3180

gttgtttcca atttaagccc caaaaccatt tgttgtatta gtggatggtg ggtaaaatat   3240

cattcactga ggtaatgatt ccccttgaga atataactct gtgtaggtca ctggaaagtg   3300

attgccatag ggctgggaga gaagcattgc actcttgagg ctgtagcctg tgtcaagctg   3360

tttcttcagg cagcctctca aatgtgcttt gtctctctgt gctgaggcct ggaccctgtg   3420

ctgagctggt gactcactgt cctgacaagt ggacacacag atgcactgct gtgctgcttt   3480

cctgaggtgg ttttctatgc ctgttttcct ctgaaacatg tctgttaccc ctctccatct   3540

taccaagttg aaaaggggaa tatttggcca catacccctc tggttttcgt aggttctttt   3600

ggttcagaat attgtttgtg ccagtacatg accttaactt ccttcctcag agcactgagc   3660

tgccatctgg gctattctgg ggtagaagga aggctgggag tggtgggaat tttataaata   3720

tttattctct tttctttgtt tcataggagt cttgtgttat acaaggttag tccttcatgg   3780

tataatctta ctgatgcact gggcctatct ttttgttttc cagccagttg aatagattag   3840

tttttctcag taacttacta tccagcagac tggctttcct gagacttgag gttgtggctt   3900

atactggaat gagaccactg tacgtgtagg tggttcagat cctgcgtaat ggcagcatga   3960

ggacttaaaa ggtggttttc attttgaaga tggctatgta gcttgtaagg tgtatcacag   4020

cagtacctct catggctttt tggttccagc agtgagggca ttggtgagat caatggtaaa   4080

ctgtgcaagc tttcttttta tcattaggaa atgtgaaacg ttggacaaat tttgagtttt   4140

aacaaggaca aaaagttgaa agaaaaggca cagttaacaa aaaagggtgg ctagatttat   4200

cttgggtgat ggaggaaatg agagaggaat gctcttgaaa ggtggtctgt ggatctgtct   4260

gaatagaaag agcacagtaa gtatgcattg ccggagaaaa cgtccttgaa gctgcttgtc   4320

tcatgtgtat gatgtgcttt ttaaatcatg cccctcgttg cctgcctaat ctgtgactcc   4380

ctaaaaacta actgggccca tgtagatggg gctgcaacca gagctgaata acatgttagg   4440

ctcacacatg catcagcact gcacactgga atcattgctc ttcctggact ttgtagaaat   4500

cagtctcaag tgcttcaaga gtctggctcc tgctactttt atctgtcagg tagcacataa   4560

ggtttgcagg gtttatattt tgtatagaat cacagttgtg gagaaaaagt aataatttct   4620

caatgaattt taaaaatggg cctattttct atccccgtgg ttcatctgat ataattagtg   4680

ttccctgtga attccccccc tctatgggaa ggatgccttt actctttatc agtaataaat   4740

tatgactgtt ttcatattgc cttagggtta tttccctgtg taaaccattg tcttttgttt   4800

tggttttctt tagcattatg aagctttggt attgtacaag gtcagtagta agatgctcac   4860

tagtctcagg gcttgtgtaa tattctggga ggtcatttaa atgccagaaa tggtcaagca   4920

attatacaca gtatttatga ctctgttaag cataccgttt gtctgtcaca ttagtagatt   4980

ctgagattaa aaaaaatttt taaagagtga tcatttaaat aatttctaaa agggtctttt   5040

caagctctaa caaagtcact aacaaatgca ttattttcta cagaattaga tgttagtagt   5100

acagtactgc atattcaggg aaaaagtgtg aggaattgat ttcaaaatag ttcgttcttg   5160

tgtttgacct aagaatgatt gtcgcatgaa gtgtttgttt ttacagttta gcatatataa   5220

acaaacatga taggattcct taagatgtta ccacccaggg ggccacaagc cagcctgctg   5280

tctcaggaag ctgtagaagg agtgtttgtc aatttcttgt cactggtttg ctgacttact   5340

gaggattaat tgttgcctta caatgttact gaaataaact gtttaat                 5387


<210>  87
<211>  202
<212>  PRT
<213>  Homo sapiens

<400>  87

Met Glu Arg Gly Ala Gly Ala Lys Leu Leu Pro Leu Leu Leu Leu Leu 
1               5                   10                  15      


Arg Ala Thr Gly Phe Thr Cys Ala Gln Thr Asp Gly Arg Asn Gly Tyr 
            20                  25                  30          


Thr Ala Val Ile Glu Val Thr Ser Gly Gly Pro Trp Gly Asp Trp Ala 
        35                  40                  45              


Trp Pro Glu Met Cys Pro Asp Gly Phe Phe Ala Ser Gly Phe Ser Leu 
    50                  55                  60                  


Lys Val Glu Pro Pro Gln Gly Ile Pro Gly Asp Asp Thr Ala Leu Asn 
65                  70                  75                  80  


Gly Ile Arg Leu His Cys Ala Arg Gly Asn Val Leu Gly Asn Thr His 
                85                  90                  95      


Val Val Glu Ser Gln Ser Gly Ser Trp Gly Glu Trp Ser Glu Pro Leu 
            100                 105                 110         


Trp Cys Arg Gly Gly Ala Tyr Leu Val Ala Phe Ser Leu Arg Val Glu 
        115                 120                 125             


Ala Pro Thr Thr Leu Gly Asp Asn Thr Ala Ala Asn Asn Val Arg Phe 
    130                 135                 140                 


Arg Cys Ser Asp Gly Glu Glu Leu Gln Gly Pro Gly Leu Ser Trp Gly 
145                 150                 155                 160 


Asp Phe Gly Asp Trp Ser Asp His Cys Pro Lys Gly Ala Cys Gly Leu 
                165                 170                 175     


Gln Thr Lys Ile Gln Gly Pro Arg Gly Leu Gly Asp Asp Thr Ala Leu 
            180                 185                 190         


Asn Asp Ala Arg Leu Phe Cys Cys Arg Ser 
        195                 200         


<210>  88
<211>  70
<212>  PRT
<213>  Homo sapiens

<400>  88

Met Glu Arg Gly Ala Gly Ala Lys Leu Leu Pro Leu Leu Leu Leu Leu 
1               5                   10                  15      


Arg Ala Thr Gly Phe Thr Cys Ala Gln Thr Asp Gly Arg Asn Gly Tyr 
            20                  25                  30          


Thr Ala Val Ile Glu Val Thr Ser Gly Gly Pro Trp Gly Asp Trp Ala 
        35                  40                  45              


Trp Pro Glu Met Cys Pro Asp Gly Phe Phe Ala Ser Gly Phe Ser Leu 
    50                  55                  60                  


Lys Leu Gly Arg Met Glu 
65                  70  


<210>  89
<211>  102
<212>  PRT
<213>  Homo sapiens

<400>  89

Met Glu Arg Gly Ala Gly Ala Lys Leu Leu Pro Leu Leu Leu Leu Leu 
1               5                   10                  15      


Arg Ala Thr Gly Phe Thr Cys Ala Gln Thr Asp Gly Arg Asn Gly Tyr 
            20                  25                  30          


Thr Ala Val Ile Glu Val Thr Ser Gly Gly Pro Trp Gly Asp Trp Ala 
        35                  40                  45              


Trp Pro Glu Met Cys Pro Asp Gly Phe Phe Ala Ser Gly Phe Ser Leu 
    50                  55                  60                  


Lys Val Glu Pro Pro Gln Gly Ile Pro Gly Asp Asp Thr Ala Leu Asn 
65                  70                  75                  80  


Gly Ile Arg Leu His Cys Ala Arg Gly Asn Val Leu Gly Asn Thr His 
                85                  90                  95      


Val Leu Gly Arg Met Glu 
            100         


<210>  90
<211>  114
<212>  PRT
<213>  Homo sapiens

<400>  90

Met Glu Arg Gly Ala Gly Ala Lys Leu Leu Pro Leu Leu Leu Leu Leu 
1               5                   10                  15      


Arg Ala Thr Gly Phe Thr Cys Ala Gln Thr Asp Gly Arg Asn Gly Tyr 
            20                  25                  30          


Thr Ala Val Ile Glu Val Thr Ser Gly Gly Pro Trp Gly Asp Trp Ala 
        35                  40                  45              


Trp Pro Glu Met Cys Pro Asp Gly Phe Phe Ala Ser Gly Phe Ser Leu 
    50                  55                  60                  


Lys Val Glu Pro Pro Gln Gly Ile Pro Gly Asp Asp Thr Ala Leu Asn 
65                  70                  75                  80  


Gly Ile Arg Leu His Cys Ala Arg Gly Asn Val Leu Gly Asn Thr His 
                85                  90                  95      


Val Val Glu Ser Gln Ser Gly Arg Trp Gly Ala Gly Val Glu Asp Pro 
            100                 105                 110         


Leu Gly 
        


<210>  91
<211>  769
<212>  DNA
<213>  Homo sapiens

<400>  91
ggaggccctt ccgcaatcgg agccctcaca gaggccaaac tgatataaat ctgcttagga     60

ggcctgattc acagacgcta caggatggag cggggcgcag gagccaagct gctgccgctg    120

ctgctgcttc tgcgggcgac tggtttcaca tgtgcacaga cagatggccg gaacggctac    180

acggcggtca tcgaagtgac cagcgggggt ccctggggcg actgggcctg gcctgagatg    240

tgtcccgatg gattcttcgc cagcgggttc tcgctcaagg tggagcctcc ccaaggcatt    300

cctggcgacg acactgcact gaatgggatc aggctgcact gcgcgcgcgg gaacgtccta    360

ggcaatacgc acgtggtaga gtcccagtct ggaagctggg gcgaatggag tgagccgctg    420

tggtgtcgcg gcggcgccta cctagtggct ttctcgcttc gcgtggaggc acccacgacc    480

ctcggtgaca acacagcagc gaacaacgtg cgcttccgct gttcagacgg cgaggaactg    540

caggggcctg ggctgagctg gggagacttt ggagactgga gtgaccattg ccccaagggc    600

gcgtgcggcc tgcagaccaa gatccaggga cctagaggcc tcggcgatga cactgcgctg    660

aacgacgcgc gcttattctg ctgccgcagt tgaacggcgc cgccgccgcc gctctctccc    720

gggccaggag gctagtccca cctcttgcta ttaaagcttc tctgagttg                769


<210>  92
<211>  653
<212>  DNA
<213>  Homo sapiens

<400>  92
ggaggccctt ccgcaatcgg agccctcaca gaggccaaac tgatataaat ctgcttagga     60

ggcctgattc acagacgcta caggatggag cggggcgcag gagccaagct gctgccgctg    120

ctgctgcttc tgcgggcgac tggtttcaca tgtgcacaga cagatggccg gaacggctac    180

acggcggtca tcgaagtgac cagcgggggt ccctggggcg actgggcctg gcctgagatg    240

tgtcccgatg gattcttcgc cagcgggttc tcgctcaagc tggggcgaat ggagtgagcc    300

gctgtggtgt cgcggcggcg cctacctagt ggctttctcg cttcgcgtgg aggcacccac    360

gaccctcggt gacaacacag cagcgaacaa cgtgcgcttc cgctgttcag acggcgagga    420

actgcagggg cctgggctga gctggggaga ctttggagac tggagtgacc attgccccaa    480

gggcgcgtgc ggcctgcaga ccaagatcca gggacctaga ggcctcggcg atgacactgc    540

gctgaacgac gcgcgcttat tctgctgccg cagttgaacg gcgccgccgc cgccgctctc    600

tcccgggcca ggaggctagt cccacctctt gctattaaag cttctctgag ttg           653


<210>  93
<211>  747
<212>  DNA
<213>  Homo sapiens

<400>  93
aggcccttcc gcaatcggag ccctcacaga ggccaaactg atataaatct gcttaggagg     60

cctgattcac agacgctaca ggatggagcg gggcgcagga gccaagctgc tgccgctgct    120

gctgcttctg cgggcgactg gtttcacatg tgcacagaca gatggccgga acggctacac    180

ggcggtcatc gaagtgacca gcgggggtcc ctggggcgac tgggcctggc ctgagatgtg    240

tcccgatgga ttcttcgcca gcgggttctc gctcaaggtg gagcctcccc aaggcattcc    300

tggcgacgac actgcactga atgggatcag gctgcactgc gcgcgcggga acgtcctagg    360

caatacgcac gtgctggggc gaatggagtg agccgctgtg gtgtcgcggc ggcgcctacc    420

tagtggcttt ctcgcttcgc gtggaggcac ccacgaccct cggtgacaac acagcagcga    480

acaacgtgcg cttccgctgt tcagacggcg aggaactgca ggggcctggg ctgagctggg    540

gagactttgg agactggagt gaccattgcc ccaagggcgc gtgcggcctg cagaccaaga    600

tccagggacc tagaggcctc ggcgatgaca ctgcgctgaa cgacgcgcgc ttattctgct    660

gccgcagttg aacggcgccg ccgccgccgc tctctcccgg gccaggaggc tagtcccacc    720

tcttgctatt aaagcttctc tgagttg                                        747


<210>  94
<211>  803
<212>  DNA
<213>  Homo sapiens

<400>  94
aggcccttcc gcaatcggag ccctcacaga ggccaaactg atataaatct gcttaggagg     60

cctgattcac agacgctaca ggatggagcg gggcgcagga gccaagctgc tgccgctgct    120

gctgcttctg cgggcgactg gtttcacatg tgcacagaca gatggccgga acggctacac    180

ggcggtcatc gaagtgacca gcgggggtcc ctggggcgac tgggcctggc ctgagatgtg    240

tcccgatgga ttcttcgcca gcgggttctc gctcaaggtg gagcctcccc aaggcattcc    300

tggcgacgac actgcactga atgggatcag gctgcactgc gcgcgcggga acgtcctagg    360

caatacgcac gtggtagagt cccagtctgg aaggtggggc gcaggggtcg aggatccctt    420

ggggtgatgc tggggcgaat ggagtgagcc gctgtggtgt cgcggcggcg cctacctagt    480

ggctttctcg cttcgcgtgg aggcacccac gaccctcggt gacaacacag cagcgaacaa    540

cgtgcgcttc cgctgttcag acggcgagga actgcagggg cctgggctga gctggggaga    600

ctttggagac tggagtgacc attgccccaa gggcgcgtgc ggcctgcaga ccaagatcca    660

gggacctaga ggcctcggcg atgacactgc gctgaacgac gcgcgcttat tctgctgccg    720

cagttgaacg gcgccgccgc cgccgctctc tcccgggcca ggaggctagt cccacctctt    780

gctattaaag cttctctgag ttg                                            803


<210>  95
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  95
cgaggacaat ctggatatca a                                               21


<210>  96
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  96
ctggagccct cgagcaagaa a                                               21


<210>  97
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  97
cccgtggttc atctgatata a                                               21


<210>  98
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  98
aaggactttg ctcggcgttt a                                               21


<210>  99
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  99
tacgtggatg tttgtaacgt a                                               21


<210>  100
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  100
ctcgtattgg ctcaatcata a                                               21


