                         SEQUENCE LISTING

<110>  Oregon Health and Science University
       Magun, Bruce E.
 
<120>  INHIBITING THE DELETERIOUS EFFECT OF ANTHRACYCLINES

<130>  899-83316-02

<150>  US 61/254,533
<151>  2009-10-23

<160>  10    

<170>  PatentIn version 3.5

<210>  1
<211>  2403
<212>  DNA
<213>  Homo sapiens

<400>  1
atgtcgtctc tcggtgcctc ctttgtgcaa attaaatttg atgacttgca gttttttgaa       60

aactgcggtg gaggaagttt tgggagtgtt tatcgagcca aatggatatc acaggacaag      120

gaggtggctg taaagaagct cctcaaaata gagaaagagg cagaaatact cagtgtcctc      180

agtcacagaa acatcatcca gttttatgga gtaattcttg aacctcccaa ctatggcatt      240

gtcacagaat atgcttctct gggatcactc tatgattaca ttaacagtaa cagaagtgag      300

gagatggata tggatcacat tatgacctgg gccactgatg tagccaaagg aatgcattat      360

ttacatatgg aggctcctgt caaggtgatt cacagagacc tcaagtcaag aaacgttgtt      420

atagctgctg atggagtatt gaagatctgt gactttggtg cctctcggtt ccataaccat      480

acaacacaca tgtccttggt tggaactttc ccatggatgg ctccagaagt tatccagagt      540

ctccctgtgt cagaaacttg tgacacatat tcctatggtg tggttctctg ggagatgcta      600

acaagggagg tcccctttaa aggtttggaa ggattacaag tagcttggct tgtagtggaa      660

aaaaacgaga gattaaccat tccaagcagt tgccccagaa gttttgctga actgttacat      720

cagtgttggg aagctgatgc caagaaacgg ccatcattca agcaaatcat ttcaatcctg      780

gagtccatgt caaatgacac gagccttcct gacaagtgta actcattcct acacaacaag      840

gcggagtgga ggtgcgaaat tgaggcaact cttgagaggc taaagaaact agagcgtgat      900

ctcagcttta aggagcagga gcttaaagaa cgagaaagac gtttaaagat gtgggagcaa      960

aagctgacag agcagtccaa caccccgctg ctgccttcct ttgagattgg tgcatggacg     1020

gaagacgatg tgtattgttg ggttcagcag ctcgtcagaa aaggtgactc ttcagcagag     1080

atgagtgtat atgcaagctt gtttaaagaa aacaacatta cagggaagcg gctgctgctg     1140

ctggaggaag aagacctgaa agacatgggc attgtctcca aggggcatat cattcacttc     1200

aagtcagcca ttgagaaatt aacccatgat tacataaatt tgtttcactt cccaccacta     1260

attaaggact caggaggtga acctgaagaa aatgaggaaa aaatagtgaa cctggaactg     1320

gtttttggtt ttcacttgaa accaggaact ggcccacagg attgtaagtg gaaaatgtat     1380

atggagatgg atggggatga aattgcaata acctacataa aagatgtgac attcaacact     1440

aacctacctg atgcggagat tttaaagatg acaaagccac catttgtaat ggagaagtgg     1500

attgtaggaa tagcaaaaag tcagactgtg gagtgcactg tcacatatga gagtgatgtt     1560

agaactccaa aaagcactaa acatgtccat tcgattcagt ggagtagaac aaaacctcag     1620

gatgaagtga aagcagtcca acttgccatt cagacattat tcaccaattc agatggcaac     1680

cctggaagca ggtccgactc aagtgctgat tgccagtggt tagatactct gaggatgcgg     1740

cagattgcat ccaacacttc tttacagcgt tcccagagca atcctattct ggggtcaccg     1800

ttcttctcac actttgatgg ccaggattcc tacgctgctg ctgtgagacg gccccaggtg     1860

cccattaagt atcaacagat tacacctgtg aaccagtcca gaagctcgtc tcctactcag     1920

tatggactga ccaaaaactt ctcttcccta catctcaact ctagggacag tggcttttcc     1980

agtggcaata ctgacacctc ttcagagagg ggtcgatact cagacagaag caggaacaaa     2040

tatggacgtg gtagtatatc actcaattct tctcctagag gaagatacag tggaaagagt     2100

cagcattcca ctccttcaag aggaagatac cctggaaagt tctacagggt ttctcagtca     2160

gcactcaatc ctcaccagtc gcctgacttc aagagaagcc ccagggacct ccaccaaccc     2220

aacaccatac cagggatgcc tttgcaccct gagactgact caagagccag tgaagaggac     2280

agcaaagtca gcgaaggggg ctggacaaaa gtggaatacc ggaaaaagcc ccacaggcca     2340

tctcccgcca aaaccaataa agagagagcc agaggggacc accgtggatg gagaaacttt     2400

tga                                                                   2403


<210>  2
<211>  800
<212>  PRT
<213>  Homo sapiens

<400>  2

Met Ser Ser Leu Gly Ala Ser Phe Val Gln Ile Lys Phe Asp Asp Leu 
1               5                   10                  15      


Gln Phe Phe Glu Asn Cys Gly Gly Gly Ser Phe Gly Ser Val Tyr Arg 
            20                  25                  30          


Ala Lys Trp Ile Ser Gln Asp Lys Glu Val Ala Val Lys Lys Leu Leu 
        35                  40                  45              


Lys Ile Glu Lys Glu Ala Glu Ile Leu Ser Val Leu Ser His Arg Asn 
    50                  55                  60                  


Ile Ile Gln Phe Tyr Gly Val Ile Leu Glu Pro Pro Asn Tyr Gly Ile 
65                  70                  75                  80  


Val Thr Glu Tyr Ala Ser Leu Gly Ser Leu Tyr Asp Tyr Ile Asn Ser 
                85                  90                  95      


Asn Arg Ser Glu Glu Met Asp Met Asp His Ile Met Thr Trp Ala Thr 
            100                 105                 110         


Asp Val Ala Lys Gly Met His Tyr Leu His Met Glu Ala Pro Val Lys 
        115                 120                 125             


Val Ile His Arg Asp Leu Lys Ser Arg Asn Val Val Ile Ala Ala Asp 
    130                 135                 140                 


Gly Val Leu Lys Ile Cys Asp Phe Gly Ala Ser Arg Phe His Asn His 
145                 150                 155                 160 


Thr Thr His Met Ser Leu Val Gly Thr Phe Pro Trp Met Ala Pro Glu 
                165                 170                 175     


Val Ile Gln Ser Leu Pro Val Ser Glu Thr Cys Asp Thr Tyr Ser Tyr 
            180                 185                 190         


Gly Val Val Leu Trp Glu Met Leu Thr Arg Glu Val Pro Phe Lys Gly 
        195                 200                 205             


Leu Glu Gly Leu Gln Val Ala Trp Leu Val Val Glu Lys Asn Glu Arg 
    210                 215                 220                 


Leu Thr Ile Pro Ser Ser Cys Pro Arg Ser Phe Ala Glu Leu Leu His 
225                 230                 235                 240 


Gln Cys Trp Glu Ala Asp Ala Lys Lys Arg Pro Ser Phe Lys Gln Ile 
                245                 250                 255     


Ile Ser Ile Leu Glu Ser Met Ser Asn Asp Thr Ser Leu Pro Asp Lys 
            260                 265                 270         


Cys Asn Ser Phe Leu His Asn Lys Ala Glu Trp Arg Cys Glu Ile Glu 
        275                 280                 285             


Ala Thr Leu Glu Arg Leu Lys Lys Leu Glu Arg Asp Leu Ser Phe Lys 
    290                 295                 300                 


Glu Gln Glu Leu Lys Glu Arg Glu Arg Arg Leu Lys Met Trp Glu Gln 
305                 310                 315                 320 


Lys Leu Thr Glu Gln Ser Asn Thr Pro Leu Leu Pro Ser Phe Glu Ile 
                325                 330                 335     


Gly Ala Trp Thr Glu Asp Asp Val Tyr Cys Trp Val Gln Gln Leu Val 
            340                 345                 350         


Arg Lys Gly Asp Ser Ser Ala Glu Met Ser Val Tyr Ala Ser Leu Phe 
        355                 360                 365             


Lys Glu Asn Asn Ile Thr Gly Lys Arg Leu Leu Leu Leu Glu Glu Glu 
    370                 375                 380                 


Asp Leu Lys Asp Met Gly Ile Val Ser Lys Gly His Ile Ile His Phe 
385                 390                 395                 400 


Lys Ser Ala Ile Glu Lys Leu Thr His Asp Tyr Ile Asn Leu Phe His 
                405                 410                 415     


Phe Pro Pro Leu Ile Lys Asp Ser Gly Gly Glu Pro Glu Glu Asn Glu 
            420                 425                 430         


Glu Lys Ile Val Asn Leu Glu Leu Val Phe Gly Phe His Leu Lys Pro 
        435                 440                 445             


Gly Thr Gly Pro Gln Asp Cys Lys Trp Lys Met Tyr Met Glu Met Asp 
    450                 455                 460                 


Gly Asp Glu Ile Ala Ile Thr Tyr Ile Lys Asp Val Thr Phe Asn Thr 
465                 470                 475                 480 


Asn Leu Pro Asp Ala Glu Ile Leu Lys Met Thr Lys Pro Pro Phe Val 
                485                 490                 495     


Met Glu Lys Trp Ile Val Gly Ile Ala Lys Ser Gln Thr Val Glu Cys 
            500                 505                 510         


Thr Val Thr Tyr Glu Ser Asp Val Arg Thr Pro Lys Ser Thr Lys His 
        515                 520                 525             


Val His Ser Ile Gln Trp Ser Arg Thr Lys Pro Gln Asp Glu Val Lys 
    530                 535                 540                 


Ala Val Gln Leu Ala Ile Gln Thr Leu Phe Thr Asn Ser Asp Gly Asn 
545                 550                 555                 560 


Pro Gly Ser Arg Ser Asp Ser Ser Ala Asp Cys Gln Trp Leu Asp Thr 
                565                 570                 575     


Leu Arg Met Arg Gln Ile Ala Ser Asn Thr Ser Leu Gln Arg Ser Gln 
            580                 585                 590         


Ser Asn Pro Ile Leu Gly Ser Pro Phe Phe Ser His Phe Asp Gly Gln 
        595                 600                 605             


Asp Ser Tyr Ala Ala Ala Val Arg Arg Pro Gln Val Pro Ile Lys Tyr 
    610                 615                 620                 


Gln Gln Ile Thr Pro Val Asn Gln Ser Arg Ser Ser Ser Pro Thr Gln 
625                 630                 635                 640 


Tyr Gly Leu Thr Lys Asn Phe Ser Ser Leu His Leu Asn Ser Arg Asp 
                645                 650                 655     


Ser Gly Phe Ser Ser Gly Asn Thr Asp Thr Ser Ser Glu Arg Gly Arg 
            660                 665                 670         


Tyr Ser Asp Arg Ser Arg Asn Lys Tyr Gly Arg Gly Ser Ile Ser Leu 
        675                 680                 685             


Asn Ser Ser Pro Arg Gly Arg Tyr Ser Gly Lys Ser Gln His Ser Thr 
    690                 695                 700                 


Pro Ser Arg Gly Arg Tyr Pro Gly Lys Phe Tyr Arg Val Ser Gln Ser 
705                 710                 715                 720 


Ala Leu Asn Pro His Gln Ser Pro Asp Phe Lys Arg Ser Pro Arg Asp 
                725                 730                 735     


Leu His Gln Pro Asn Thr Ile Pro Gly Met Pro Leu His Pro Glu Thr 
            740                 745                 750         


Asp Ser Arg Ala Ser Glu Glu Asp Ser Lys Val Ser Glu Gly Gly Trp 
        755                 760                 765             


Thr Lys Val Glu Tyr Arg Lys Lys Pro His Arg Pro Ser Pro Ala Lys 
    770                 775                 780                 


Thr Asn Lys Glu Arg Ala Arg Gly Asp His Arg Gly Trp Arg Asn Phe 
785                 790                 795                 800 


<210>  3
<211>  36
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic inhibitory hairpin RNA.

<400>  3
gatccgcctc tcggttccat aaccatttca agagaa                                 36


<210>  4
<211>  41
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic inhibitory hairpin RNA.

<400>  4
agcttaaaaa gcctctcggt tccataacca ttctcttgaa a                           41


<210>  5
<211>  36
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic inhibitory hairpin RNA.

<400>  5
gatccgccag tggttagata ctctgattca agagat                                 36


<210>  6
<211>  41
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic inhibitory hairpin RNA.

<400>  6
agcttaaaaa gccagtggtt agatactctg atctcttgaa t                           41


<210>  7
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic small inhibitory RNA.

<400>  7
uguucaacuc cuaacugcgt t                                                 21


<210>  8
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic small inhibitory RNA.

<400>  8
ccucaaguca agaaacguut t                                                 21


<210>  9
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic small inhibitory RNA.

<400>  9
aacguuucuu gacuugcggt t                                                 21


<210>  10
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic small inhibitory RNA.

<400>  10
caacacggac aucauacgat t                                                 21


