                         SEQUENCE LISTING

<110>  University of Pittsburgh - Of the Commonwealth System of 
       Higher Education
       Feghali-Bostwick , Carol   A
       Yamaguchi, Yukie
 
<120>  USE OF ENDOSTATIN PEPTIDES FOR THE TREATMENT OF FIBROSIS

<130>  8123-84102-03

<150>  61/261,280
<151>  2009-11-13

<150>  61/254,143
<151>  2009-10-22

<160>  13    

<170>  PatentIn version 3.5

<210>  1
<211>  555
<212>  DNA
<213>  Homo sapiens

<400>  1
atgcacagcc accgcgactt ccagccggtg ctccacctgg ttgcgctcaa cagccccctg       60

tcaggcggca tgcggggcat ccgcggggcc gacttccagt gcttccagca ggcgcgggcc      120

gtggggctgg cgggcacctt ccgcgccttc ctgtcctcgc gcctgcagga cctgtacagc      180

atcgtgcgcc gtgccgaccg cgcagccgtg cccatcgtca acctcaagga cgagctgctg      240

tttcccagct gggaggctct gttctcaggc tctgagggtc cgctgaagcc cggggcacgc      300

atcttctcct ttaacggcaa ggacgtcctg acccacccca cctggcccca gaagagcgtg      360

tggcatggct cggaccccaa cgggcgcagg ctgaccgaga gctactgtga gacgtggcgg      420

acggaggctc cctcggccac gggccaggcc tactcgctgc tggggggcag gctcctgggg      480

cagagtgccg cgagctgcca tcacgcctac atcgtgctat gcattgagaa cagcttcatg      540

actgcctcca agtag                                                       555


<210>  2
<211>  183
<212>  PRT
<213>  Homo sapiens

<400>  2

His Ser His Arg Asp Phe Gln Pro Val Leu His Leu Val Ala Leu Asn 
1               5                   10                  15      


Ser Pro Leu Ser Gly Gly Met Arg Gly Ile Arg Gly Ala Asp Phe Gln 
            20                  25                  30          


Cys Phe Gln Gln Ala Arg Ala Val Gly Leu Ala Gly Thr Phe Arg Ala 
        35                  40                  45              


Phe Leu Ser Ser Arg Leu Gln Asp Leu Tyr Ser Ile Val Arg Arg Ala 
    50                  55                  60                  


Asp Arg Ala Ala Val Pro Ile Val Asn Leu Lys Asp Glu Leu Leu Phe 
65                  70                  75                  80  


Pro Ser Trp Glu Ala Leu Phe Ser Gly Ser Glu Gly Pro Leu Lys Pro 
                85                  90                  95      


Gly Ala Arg Ile Phe Ser Phe Asn Gly Lys Asp Val Leu Thr His Pro 
            100                 105                 110         


Thr Trp Pro Gln Lys Ser Val Trp His Gly Ser Asp Pro Asn Gly Arg 
        115                 120                 125             


Arg Leu Thr Glu Ser Tyr Cys Glu Thr Trp Arg Thr Glu Ala Pro Ser 
    130                 135                 140                 


Ala Thr Gly Gln Ala Tyr Ser Leu Leu Gly Gly Arg Leu Leu Gly Gln 
145                 150                 155                 160 


Ser Ala Ala Ser Cys His His Ala Tyr Ile Val Leu Cys Ile Glu Asn 
                165                 170                 175     


Ser Phe Met Thr Ala Ser Lys 
            180             


<210>  3
<211>  552
<212>  DNA
<213>  Mus musculus

<400>  3
catactcatc aggactttca gccagtgctc cacctggtgg cactgaacac ccccctgtct       60

ggaggcatgc gtggtatccg tggagcagat ttccagtgct tccagcaagc ccgagccgtg      120

gggctgtcgg gcaccttccg ggctttcctg tcctctaggc tgcaggatct ctatagcatc      180

gtgcgccgtg ctgaccgggg gtctgtgccc atcgtcaacc tgaaggacga ggtgctatct      240

cccagctggg actccctgtt ttctggctcc cagggtcaac tgcaacccgg ggcccgcatc      300

ttttcttttg acggcagaga tgtcctgaga cacccagcct ggccgcagaa gagcgtatgg      360

cacggctcgg accccagtgg gcggaggctg atggagagtt actgtgagac atggcgaact      420

gaaactactg gggctacagg tcaggcctcc tccctgctgt caggcaggct cctggaacag      480

aaagctgcga gctgccacaa cagctacatc gtcctgtgca ttgagaatag cttcatgacc      540

tctttctcca aa                                                          552


<210>  4
<211>  184
<212>  PRT
<213>  Mus musculus

<400>  4

His Thr His Gln Asp Phe Gln Pro Val Leu His Leu Val Ala Leu Asn 
1               5                   10                  15      


Thr Pro Leu Ser Gly Gly Met Arg Gly Ile Arg Gly Ala Asp Phe Gln 
            20                  25                  30          


Cys Phe Gln Gln Ala Arg Ala Val Gly Leu Ser Gly Thr Phe Arg Ala 
        35                  40                  45              


Phe Leu Ser Ser Arg Leu Gln Asp Leu Tyr Ser Ile Val Arg Arg Ala 
    50                  55                  60                  


Asp Arg Gly Ser Val Pro Ile Val Asn Leu Lys Asp Glu Val Leu Ser 
65                  70                  75                  80  


Pro Ser Trp Asp Ser Leu Phe Ser Gly Ser Gln Gly Gln Leu Gln Pro 
                85                  90                  95      


Gly Ala Arg Ile Phe Ser Phe Asp Gly Arg Asp Val Leu Arg His Pro 
            100                 105                 110         


Ala Trp Pro Gln Lys Ser Val Trp His Gly Ser Asp Pro Ser Gly Arg 
        115                 120                 125             


Arg Leu Met Glu Ser Tyr Cys Glu Thr Trp Arg Thr Glu Thr Thr Gly 
    130                 135                 140                 


Ala Thr Gly Gln Ala Ser Ser Leu Leu Ser Gly Arg Leu Leu Glu Gln 
145                 150                 155                 160 


Lys Ala Ala Ser Cys His Asn Ser Tyr Ile Val Leu Cys Ile Glu Asn 
                165                 170                 175     


Ser Phe Met Thr Ser Phe Ser Lys 
            180                 


<210>  5
<211>  699
<212>  DNA
<213>  Homo sapiens

<400>  5
gagcccaaat cttgtgacaa aactcacaca tgcccaccgt gcccagcacc tgaactcctg       60

gggggaccgt cagtcttcct cttcccccca aaacccaagg acaccctcat gatctcccgg      120

acccctgagg tcacatgcgt ggtggtggac gtgagccacg aagaccctga ggtcaagttc      180

aactggtacg tggacggcgt ggaggtgcat aatgccaaga caaagccgcg ggaggagcag      240

tacaacagca cgtaccgtgt ggtcagcgtc ctcaccgtcc tgcaccagga ctggctgaat      300

ggcaaggagt acaagtgcaa ggtctccaac aaagccctcc cagcccccat cgagaaaacc      360

atctccaaag ccaaagggca gccccgagaa ccacaggtgt acaccctgcc cccatcccgg      420

gatgagctga ccaagaacca ggtcagcctg acctgcctgg tcaaaggctt ctatcccagc      480

gacatcgccg tggagtggga gagcaatggg cagccggaga acaactacaa gaccacgcct      540

cccgtgctgg actccgacgg ctccttcttc ctctacagca agctcaccgt ggacaagagc      600

aggtggcagc aggggaacgt cttctcatgc tccgtgatgc atgaggctct gcacaaccac      660

tacacgcaga agagcctctc cctgtctccg ggtaaatga                             699


<210>  6
<211>  244
<212>  PRT
<213>  Homo sapiens

<400>  6

Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala 
1               5                   10                  15      


Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 
            20                  25                  30          


Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 
        35                  40                  45              


Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val 
    50                  55                  60                  


Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gly 
65                  70                  75                  80  


Ile Asn Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 
                85                  90                  95      


His Gly Ile Asn Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val 
            100                 105                 110         


Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala 
        115                 120                 125             


Lys Gly Gly Ile Asn Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro 
    130                 135                 140                 


Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val 
145                 150                 155                 160 


Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly 
                165                 170                 175     


Gly Ile Asn Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp 
            180                 185                 190         


Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser 
        195                 200                 205             


Arg Trp Gln Gly Ile Asn Gly Asn Val Phe Ser Cys Ser Val Met His 
    210                 215                 220                 


Glu Ala Leu His Asn His Tyr Thr Gly Ile Asn Lys Ser Leu Ser Leu 
225                 230                 235                 240 


Ser Pro Gly Lys 
                


<210>  7
<211>  48
<212>  DNA
<213>  Homo sapiens

<400>  7
tctagaggtg gtctagtgcc gcgcggcagc ggttcccccg ggttgcag                    48


<210>  8
<211>  16
<212>  PRT
<213>  Homo sapiens

<400>  8

Ser Arg Gly Gly Leu Val Pro Arg Gly Ser Gly Ser Pro Gly Leu Gln 
1               5                   10                  15      


<210>  9
<211>  48
<212>  PRT
<213>  Rattus rattus

<400>  9

Ser Tyr Cys Glu Thr Trp Arg Thr Glu Ala Thr Gly Val Thr Gly Gln 
1               5                   10                  15      


Ala Ser Ser Leu Leu Ser Gly Arg Leu Leu Glu Gln Lys Ala Glu Ser 
            20                  25                  30          


Cys His Asn Ser Tyr Ile Val Leu Cys Ile Glu Asn Ser Phe Met Thr 
        35                  40                  45              


<210>  10
<211>  48
<212>  PRT
<213>  Bos taurus

<400>  10

Ser Tyr Cys Glu Thr Trp Arg Thr Asp Ser Arg Ala Ala Thr Gly Gln 
1               5                   10                  15      


Ala Ser Ser Leu Leu Ala Gly Arg Leu Leu Glu Gln Lys Ala Ala Gly 
            20                  25                  30          


Cys His Asn Ala Phe Ile Val Leu Cys Ile Glu Asn Ser Phe Met Thr 
        35                  40                  45              


<210>  11
<211>  48
<212>  PRT
<213>  Homo sapiens

<400>  11

Asn Tyr Cys Glu Ala Trp Arg Thr Ala Asp Thr Ala Val Thr Gly Leu 
1               5                   10                  15      


Ala Ser Pro Leu Ser Thr Gly Lys Ile Leu Asp Gln Lys Ala Tyr Ser 
            20                  25                  30          


Cys Ala Asn Arg Leu Ile Val Leu Cys Ile Glu Asn Ser Phe Met Thr 
        35                  40                  45              


<210>  12
<211>  552
<212>  DNA
<213>  Homo sapiens

<400>  12
cacagccacc gcgacttcca gccggtgctc cacctggttg cgctcaacag ccccctgtca       60

ggcggcatgc ggggcatccg cggggccgac ttccagtgct tccagcaggc gcgggccgtg      120

gggctggcgg gcaccttccg cgccttcctg tcctcgcgcc tgcaggacct gtacagcatc      180

gtgcgccgtg ccgaccgcgc agccgtgccc atcgtcaacc tcaaggacga gctgctgttt      240

cccagctggg aggctctgtt ctcaggctct gagggtccgc tgaagcccgg ggcacgcatc      300

ttctcctttg acggcaagga cgtcctgagg caccccacct ggccccagaa gagcgtgtgg      360

catggctcgg accccaacgg gcgcaggctg accgagagct actgtgagac gtggcggacg      420

gaggctccct cggccacggg ccaggcctcc tcgctgctgg ggggcaggct cctggggcag      480

agtgccgcga gctgccatca cgcctacatc gtgctctgca ttgagaacag cttcatgact      540

gcctccaagt ag                                                          552


<210>  13
<211>  183
<212>  PRT
<213>  Homo sapiens

<400>  13

His Ser His Arg Asp Phe Gln Pro Val Leu His Leu Val Ala Leu Asn 
1               5                   10                  15      


Ser Pro Leu Ser Gly Gly Met Arg Gly Ile Arg Gly Ala Asp Phe Gln 
            20                  25                  30          


Cys Phe Gln Gln Ala Arg Ala Val Gly Leu Ala Gly Thr Phe Arg Ala 
        35                  40                  45              


Phe Leu Ser Ser Arg Leu Gln Asp Leu Tyr Ser Ile Val Arg Arg Ala 
    50                  55                  60                  


Asp Arg Ala Ala Val Pro Ile Val Asn Leu Lys Asp Glu Leu Leu Phe 
65                  70                  75                  80  


Pro Ser Trp Glu Ala Leu Phe Ser Gly Ser Glu Gly Pro Leu Lys Pro 
                85                  90                  95      


Gly Ala Arg Ile Phe Ser Phe Asp Gly Lys Asp Val Leu Arg His Pro 
            100                 105                 110         


Thr Trp Pro Gln Lys Ser Val Trp His Gly Ser Asp Pro Asn Gly Arg 
        115                 120                 125             


Arg Leu Thr Glu Ser Tyr Cys Glu Thr Trp Arg Thr Glu Ala Pro Ser 
    130                 135                 140                 


Ala Thr Gly Gln Ala Ser Ser Leu Leu Gly Gly Arg Leu Leu Gly Gln 
145                 150                 155                 160 


Ser Ala Ala Ser Cys His His Ala Tyr Ile Val Leu Cys Ile Glu Asn 
                165                 170                 175     


Ser Phe Met Thr Ala Ser Lys 
            180             


