                               SEQUENCE LISTING	

<110> GENENTECH, INC. et al.
 
<120> METHODS AND COMPOSITIONS FOR MODULATING HEPSIN ACTIVATION OF 
      MACROPHAGE-STIMULATING PROTEIN

<130> P4379R1 WO

<140>
<141>

<150> 61/253,990
<151> 2009-10-22

<160> 20    

<170> PatentIn version 3.5

<210> 1
<211> 5
<212> PRT
<213> Unknown

<220>
<221> source
<223> /note="Description of Unknown: Pro-MSP cleavage sequence"

<400> 1
Ser Lys Leu Arg Val 
1               5   


<210> 2
<211> 11
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 2
Arg Ala Ser Gln Ser Val Ser Ser Ala Val Ala 
1               5                   10      


<210> 3
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 3
Ser Ala Ser Ser Leu Tyr Ser 
1               5           


<210> 4
<211> 11
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 4
Gln Gln Tyr Tyr Ser Ser Tyr Tyr Leu Leu Thr 
1               5                   10      


<210> 5
<211> 10
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 5
Gly Phe Asn Phe Ser Tyr Ser Tyr Met His 
1               5                   10  


<210> 6
<211> 18
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 6
Ala Ser Ile Tyr Ser Tyr Tyr Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
1               5                   10                  15      


Lys Gly 
        


<210> 7
<211> 23
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 7
Ala Arg Ser Asp Ser Trp Ser Tyr Lys Ser Gly Tyr Thr Gln Lys Ile 
1               5                   10                  15      


Tyr Ser Lys Gly Leu Asp Tyr 
            20              


<210> 8
<211> 109
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 8
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Val Ser Ser Ala 
            20                  25                  30          


Val Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ser Ala Ser Ser Leu Tyr Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Arg Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Tyr Ser Ser Tyr Tyr 
                85                  90                  95      


Leu Leu Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105                 


<210> 9
<211> 130
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 9
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Asn Phe Ser Tyr Ser 
            20                  25                  30          


Tyr Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Ser Ile Tyr Ser Tyr Tyr Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Ala Asp Thr Ser Lys Asn Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ser Asp Ser Trp Ser Tyr Lys Ser Gly Tyr Thr Gln Lys Ile 
            100                 105                 110         


Tyr Ser Lys Gly Leu Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val 
        115                 120                 125             


Ser Ser 
    130 


<210> 10
<211> 4
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 10
Lys Gln Leu Arg 
1               


<210> 11
<211> 5
<212> PRT
<213> Unknown

<220>
<221> source
<223> /note="Description of Unknown: ProHGF substrate recognition 
      sequence"

<400> 11
Lys Gln Leu Arg Val 
1               5   


<210> 12
<211> 5
<212> PRT
<213> Unknown

<220>
<221> source
<223> /note="Description of Unknown: Ln-332 substrate recognition 
      sequence"

<400> 12
Ser Gln Leu Arg Leu 
1               5   


<210> 13
<211> 5
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Unknown: Pro-uPA substrate recognition 
      sequence"

<400> 13
Pro Arg Phe Lys Ile 
1               5   


<210> 14
<211> 5
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Unknown:  FVII substrate recognition 
      sequence"


<400> 14
Pro Gln Gly Arg Ile 
1               5   


<210> 15
<211> 5
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Unknown: Pro-tPA substrate recognition 
      sequence"

<400> 15
Pro Gln Phe Arg Ile 
1               5   


<210> 16
<211> 5
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Unknown: Plasminogen substrate recognition 
      sequence"

<400> 16
Cys Pro Gly Arg Val 
1               5   


<210> 17
<211> 7
<212> PRT
<213> Homo sapiens

<400> 17
Val Val Gly Gly His Pro Gly 
1               5           


<210> 18
<211> 417
<212> PRT
<213> Homo sapiens

<400> 18
Met Ala Gln Lys Glu Gly Gly Arg Thr Val Pro Cys Cys Ser Arg Pro 
1               5                   10                  15      


Lys Val Ala Ala Leu Thr Ala Gly Thr Leu Leu Leu Leu Thr Ala Ile 
            20                  25                  30          


Gly Ala Ala Ser Trp Ala Ile Val Ala Val Leu Leu Arg Ser Asp Gln 
        35                  40                  45              


Glu Pro Leu Tyr Pro Val Gln Val Ser Ser Ala Asp Ala Arg Leu Met 
    50                  55                  60                  


Val Phe Asp Lys Thr Glu Gly Thr Trp Arg Leu Leu Cys Ser Ser Arg 
65                  70                  75                  80  


Ser Asn Ala Arg Val Ala Gly Leu Ser Cys Glu Glu Met Gly Phe Leu 
                85                  90                  95      


Arg Ala Leu Thr His Ser Glu Leu Asp Val Arg Thr Ala Gly Ala Asn 
            100                 105                 110         


Gly Thr Ser Gly Phe Phe Cys Val Asp Glu Gly Arg Leu Pro His Thr 
        115                 120                 125             


Gln Arg Leu Leu Glu Val Ile Ser Val Cys Asp Cys Pro Arg Gly Arg 
    130                 135                 140                 


Phe Leu Ala Ala Ile Cys Gln Asp Cys Gly Arg Arg Lys Leu Pro Val 
145                 150                 155                 160 


Asp Arg Ile Val Gly Gly Arg Asp Thr Ser Leu Gly Arg Trp Pro Trp 
                165                 170                 175     


Gln Val Ser Leu Arg Tyr Asp Gly Ala His Leu Cys Gly Gly Ser Leu 
            180                 185                 190         


Leu Ser Gly Asp Trp Val Leu Thr Ala Ala His Cys Phe Pro Glu Arg 
        195                 200                 205             


Asn Arg Val Leu Ser Arg Trp Arg Val Phe Ala Gly Ala Val Ala Gln 
    210                 215                 220                 


Ala Ser Pro His Gly Leu Gln Leu Gly Val Gln Ala Val Val Tyr His 
225                 230                 235                 240 


Gly Gly Tyr Leu Pro Phe Arg Asp Pro Asn Ser Glu Glu Asn Ser Asn 
                245                 250                 255     


Asp Ile Ala Leu Val His Leu Ser Ser Pro Leu Pro Leu Thr Glu Tyr 
            260                 265                 270         


Ile Gln Pro Val Cys Leu Pro Ala Ala Gly Gln Ala Leu Val Asp Gly 
        275                 280                 285             


Lys Ile Cys Thr Val Thr Gly Trp Gly Asn Thr Gln Tyr Tyr Gly Gln 
    290                 295                 300                 


Gln Ala Gly Val Leu Gln Glu Ala Arg Val Pro Ile Ile Ser Asn Asp 
305                 310                 315                 320 


Val Cys Asn Gly Ala Asp Phe Tyr Gly Asn Gln Ile Lys Pro Lys Met 
                325                 330                 335     


Phe Cys Ala Gly Tyr Pro Glu Gly Gly Ile Asp Ala Cys Gln Gly Asp 
            340                 345                 350         


Ser Gly Gly Pro Phe Val Cys Glu Asp Ser Ile Ser Arg Thr Pro Arg 
        355                 360                 365             


Trp Arg Leu Cys Gly Ile Val Ser Trp Gly Thr Gly Cys Ala Leu Ala 
    370                 375                 380                 


Gln Lys Pro Gly Val Tyr Thr Lys Val Ser Asp Phe Arg Glu Trp Ile 
385                 390                 395                 400 


Phe Gln Ala Ile Lys Thr His Ser Glu Ala Ser Gly Met Val Thr Gln 
                405                 410                 415     


Leu 
    


<210> 19
<211> 476
<212> PRT
<213> Homo sapiens

<400> 19
Met Ala Gln Lys Glu Gly Gly Arg Thr Val Pro Cys Cys Ser Arg Pro 
1               5                   10                  15      


Lys Val Ala Ala Leu Thr Ala Gly Thr Leu Leu Leu Leu Thr Ala Ile 
            20                  25                  30          


Gly Ala Ala Ser Trp Ala Ile Val Ala Val Leu Leu Arg Ser Asp Gln 
        35                  40                  45              


Glu Pro Leu Tyr Pro Val Gln Val Ser Ser Ala Asp Ala Arg Leu Met 
    50                  55                  60                  


Val Phe Asp Lys Thr Glu Gly Thr Trp Arg Leu Leu Cys Ser Ser Arg 
65                  70                  75                  80  


Ser Asn Ala Arg Val Ala Gly Leu Ser Cys Glu Glu Met Gly Phe Leu 
                85                  90                  95      


Arg Ala Leu Thr His Ser Glu Leu Asp Val Arg Thr Ala Gly Ala Asn 
            100                 105                 110         


Gly Thr Ser Gly Phe Phe Cys Val Asp Glu Gly Arg Leu Pro His Thr 
        115                 120                 125             


Gln Arg Leu Leu Glu Val Ile Ser Val Cys Asp Cys Pro Arg Gly Arg 
    130                 135                 140                 


Phe Leu Ala Ala Ile Cys Gln Gly Glu Ile Leu Lys Leu Arg Thr Leu 
145                 150                 155                 160 


Ser Phe Arg Pro Leu Gly Arg Pro Arg Pro Leu Lys Leu Pro Arg Met 
                165                 170                 175     


Gly Pro Cys Thr Phe Arg Pro Pro Arg Ala Gly Pro Ser Leu Gly Ser 
            180                 185                 190         


Gly Asp Leu Gly Ser Ser Pro Leu Ser Pro Pro Pro Ala Asp Pro Cys 
        195                 200                 205             


Pro Thr Asp Cys Gly Arg Arg Lys Leu Pro Val Asp Arg Ile Val Gly 
    210                 215                 220                 


Gly Arg Asp Thr Ser Leu Gly Arg Trp Pro Trp Gln Val Ser Leu Arg 
225                 230                 235                 240 


Tyr Asp Gly Ala His Leu Cys Gly Gly Ser Leu Leu Ser Gly Asp Trp 
                245                 250                 255     


Val Leu Thr Ala Ala His Cys Phe Pro Glu Arg Asn Arg Val Leu Ser 
            260                 265                 270         


Arg Trp Arg Val Phe Ala Gly Ala Val Ala Gln Ala Ser Pro His Gly 
        275                 280                 285             


Leu Gln Leu Gly Val Gln Ala Val Val Tyr His Gly Gly Tyr Leu Pro 
    290                 295                 300                 


Phe Arg Asp Pro Asn Ser Glu Glu Asn Ser Asn Asp Ile Ala Leu Val 
305                 310                 315                 320 


His Leu Ser Ser Pro Leu Pro Leu Thr Glu Tyr Ile Gln Pro Val Cys 
                325                 330                 335     


Leu Pro Ala Ala Gly Gln Ala Leu Val Asp Gly Lys Ile Cys Thr Val 
            340                 345                 350         


Thr Gly Trp Gly Asn Thr Gln Tyr Tyr Gly Gln Gln Ala Gly Val Leu 
        355                 360                 365             


Gln Glu Ala Arg Val Pro Ile Ile Ser Asn Asp Val Cys Asn Gly Ala 
    370                 375                 380                 


Asp Phe Tyr Gly Asn Gln Ile Lys Pro Lys Met Phe Cys Ala Gly Tyr 
385                 390                 395                 400 


Pro Glu Gly Gly Ile Asp Ala Cys Gln Gly Asp Ser Gly Gly Pro Phe 
                405                 410                 415     


Val Cys Glu Asp Ser Ile Ser Arg Thr Pro Arg Trp Arg Leu Cys Gly 
            420                 425                 430         


Ile Val Ser Trp Gly Thr Gly Cys Ala Leu Ala Gln Lys Pro Gly Val 
        435                 440                 445             


Tyr Thr Lys Val Ser Asp Phe Arg Glu Trp Ile Phe Gln Ala Ile Lys 
    450                 455                 460                 


Thr His Ser Glu Ala Ser Gly Met Val Thr Gln Leu 
465                 470                 475     


<210> 20
<211> 711
<212> PRT
<213> Homo sapiens

<400> 20
Met Gly Trp Leu Pro Leu Leu Leu Leu Leu Thr Gln Cys Leu Gly Val 
1               5                   10                  15      


Pro Gly Gln Arg Ser Pro Leu Asn Asp Phe Gln Val Leu Arg Gly Thr 
            20                  25                  30          


Glu Leu Gln His Leu Leu His Ala Val Val Pro Gly Pro Trp Gln Glu 
        35                  40                  45              


Asp Val Ala Asp Ala Glu Glu Cys Ala Gly Arg Cys Gly Pro Leu Met 
    50                  55                  60                  


Asp Cys Arg Ala Phe His Tyr Asn Val Ser Ser His Gly Cys Gln Leu 
65                  70                  75                  80  


Leu Pro Trp Thr Gln His Ser Pro His Thr Arg Leu Arg Arg Ser Gly 
                85                  90                  95      


Arg Cys Asp Leu Phe Gln Lys Lys Asp Tyr Val Arg Thr Cys Ile Met 
            100                 105                 110         


Asn Asn Gly Val Gly Tyr Arg Gly Thr Met Ala Thr Thr Val Gly Gly 
        115                 120                 125             


Leu Pro Cys Gln Ala Trp Ser His Lys Phe Pro Asn Asp His Lys Tyr 
    130                 135                 140                 


Thr Pro Thr Leu Arg Asn Gly Leu Glu Glu Asn Phe Cys Arg Asn Pro 
145                 150                 155                 160 


Asp Gly Asp Pro Gly Gly Pro Trp Cys Tyr Thr Thr Asp Pro Ala Val 
                165                 170                 175     


Arg Phe Gln Ser Cys Gly Ile Lys Ser Cys Arg Glu Ala Ala Cys Val 
            180                 185                 190         


Trp Cys Asn Gly Glu Glu Tyr Arg Gly Ala Val Asp Arg Thr Glu Ser 
        195                 200                 205             


Gly Arg Glu Cys Gln Arg Trp Asp Leu Gln His Pro His Gln His Pro 
    210                 215                 220                 


Phe Glu Pro Gly Lys Phe Leu Asp Gln Gly Leu Asp Asp Asn Tyr Cys 
225                 230                 235                 240 


Arg Asn Pro Asp Gly Ser Glu Arg Pro Trp Cys Tyr Thr Thr Asp Pro 
                245                 250                 255     


Gln Ile Glu Arg Glu Phe Cys Asp Leu Pro Arg Cys Gly Ser Glu Ala 
            260                 265                 270         


Gln Pro Arg Gln Glu Ala Thr Thr Val Ser Cys Phe Arg Gly Lys Gly 
        275                 280                 285             


Glu Gly Tyr Arg Gly Thr Ala Asn Thr Thr Thr Ala Gly Val Pro Cys 
    290                 295                 300                 


Gln Arg Trp Asp Ala Gln Ile Pro His Gln His Arg Phe Thr Pro Glu 
305                 310                 315                 320 


Lys Tyr Ala Cys Lys Asp Leu Arg Glu Asn Phe Cys Arg Asn Pro Asp 
                325                 330                 335     


Gly Ser Glu Ala Pro Trp Cys Phe Thr Leu Arg Pro Gly Met Arg Ala 
            340                 345                 350         


Ala Phe Cys Tyr Gln Ile Arg Arg Cys Thr Asp Asp Val Arg Pro Gln 
        355                 360                 365             


Asp Cys Tyr His Gly Ala Gly Glu Gln Tyr Arg Gly Thr Val Ser Lys 
    370                 375                 380                 


Thr Arg Lys Gly Val Gln Cys Gln Arg Trp Ser Ala Glu Thr Pro His 
385                 390                 395                 400 


Lys Pro Gln Phe Thr Phe Thr Ser Glu Pro His Ala Gln Leu Glu Glu 
                405                 410                 415     


Asn Phe Cys Arg Asn Pro Asp Gly Asp Ser His Gly Pro Trp Cys Tyr 
            420                 425                 430         


Thr Met Asp Pro Arg Thr Pro Phe Asp Tyr Cys Ala Leu Arg Arg Cys 
        435                 440                 445             


Ala Asp Asp Gln Pro Pro Ser Ile Leu Asp Pro Pro Asp Gln Val Gln 
    450                 455                 460                 


Phe Glu Lys Cys Gly Lys Arg Val Asp Arg Leu Asp Gln Arg Arg Ser 
465                 470                 475                 480 


Lys Leu Arg Val Val Gly Gly His Pro Gly Asn Ser Pro Trp Thr Val 
                485                 490                 495     


Ser Leu Arg Asn Arg Gln Gly Gln His Phe Cys Gly Gly Ser Leu Val 
            500                 505                 510         


Lys Glu Gln Trp Ile Leu Thr Ala Arg Gln Cys Phe Ser Ser Cys His 
        515                 520                 525             


Met Pro Leu Thr Gly Tyr Glu Val Trp Leu Gly Thr Leu Phe Gln Asn 
    530                 535                 540                 


Pro Gln His Gly Glu Pro Ser Leu Gln Arg Val Pro Val Ala Lys Met 
545                 550                 555                 560 


Val Cys Gly Pro Ser Gly Ser Gln Leu Val Leu Leu Lys Leu Glu Arg 
                565                 570                 575     


Ser Val Thr Leu Asn Gln Arg Val Ala Leu Ile Cys Leu Pro Pro Glu 
            580                 585                 590         


Trp Tyr Val Val Pro Pro Gly Thr Lys Cys Glu Ile Ala Gly Trp Gly 
        595                 600                 605             


Glu Thr Lys Gly Thr Gly Asn Asp Thr Val Leu Asn Val Ala Leu Leu 
    610                 615                 620                 


Asn Val Ile Ser Asn Gln Glu Cys Asn Ile Lys His Arg Gly Arg Val 
625                 630                 635                 640 


Arg Glu Ser Glu Met Cys Thr Glu Gly Leu Leu Ala Pro Val Gly Ala 
                645                 650                 655     


Cys Glu Gly Asp Tyr Gly Gly Pro Leu Ala Cys Phe Thr His Asn Cys 
            660                 665                 670         


Trp Val Leu Glu Gly Ile Ile Ile Pro Asn Arg Val Cys Ala Arg Ser 
        675                 680                 685             


Arg Trp Pro Ala Val Phe Thr Arg Val Ser Val Phe Val Asp Trp Ile 
    690                 695                 700                 


His Lys Val Met Arg Leu Gly 
705                 710     


