                               SEQUENCE LISTING	

<110> FERRING B.V.
 
<120> PEPTIDIC GLP-2 AGONISTS

<130> 25709-17274 PCT

<140> PCT/US2010/053570
<141> 2010-10-21

<150> 61/254,490
<151> 2009-10-23

<150> EP 09173900.3
<151> 2009-10-23

<160> 74    

<170> PatentIn version 3.5

<210> 1
<211> 33
<212> PRT
<213> Homo sapiens

<400> 1
His Ala Asp Gly Ser Phe Ser Asp Glu Met Asn Thr Ile Leu Asp Asn 
1               5                   10                  15      


Leu Ala Ala Arg Asp Phe Ile Asn Trp Leu Ile Gln Thr Lys Ile Thr 
            20                  25                  30          


Asp 
    


<210> 2
<211> 5
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 2
Ser Phe Ser Asp Glu 
1               5   


<210> 3
<211> 4
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 3
Thr Ile Leu Asp 
1               


<210> 4
<211> 14
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide


<220>
<221> MOD_RES
<222> (9)..(9)
<223> Gln or Arg

<220>
<221> MOD_RES
<222> (12)..(14)
<223> Val, Leu, Ile, Ser, Thr, Asp, Glu or absent

<220> 
<223> see specification as filed for detailed description of
      substitutions and preferred embodiments

<400> 4
Arg Asp Phe Ile Asn Trp Leu Ile Xaa Thr Lys Xaa Xaa Xaa 
1               5                   10                  


<210> 5
<211> 30
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide


<220>
<221> MOD_RES
<222> (4)..(4)
<223> D-Ala

<220>
<221> MOD_RES
<222> (10)..(10)
<223> Nle 

<220>
<223> C-term amidated

<400> 5
His Gly Asp Xaa Ser Phe Ser Asp Glu Xaa Asn Thr Ile Leu Asp Asn 
1               5                   10                  15      


Leu Ala Ala Arg Asp Phe Ile Asn Trp Leu Ile Gln Thr Lys 
            20                  25                  30  


<210> 6
<211> 30
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide


<220>
<221> MOD_RES
<222> (1)..(1)
<223> 2-PhEtHis

<220>
<221> MOD_RES
<222> (10)..(10)
<223> Nle 

<220>
<223> C-term amidated

<400> 6
Xaa Ala Asp Gly Ser Phe Ser Asp Glu Xaa Asn Thr Ile Leu Asp Asn 
1               5                   10                  15      


Leu Ala Ala Arg Asp Phe Ile Asn Trp Leu Ile Gln Thr Lys 
            20                  25                  30  


<210> 7
<211> 30
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide


<220>
<221> MOD_RES
<222> (1)..(1)
<223> 3-MeBuHis

<220>
<221> MOD_RES
<222> (10)..(10)
<223> Nle 

<220>
<223> C-term amidated

<400> 7
Xaa Ala Asp Gly Ser Phe Ser Asp Glu Xaa Asn Thr Ile Leu Asp Asn 
1               5                   10                  15      


Leu Ala Ala Arg Asp Phe Ile Asn Trp Leu Ile Gln Thr Lys 
            20                  25                  30  


<210> 8
<211> 30
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide


<220>
<221> MOD_RES
<222> (1)..(1)
<223> OctHis

<220>
<221> MOD_RES
<222> (10)..(10)
<223> Nle 

<220>
<223> C-term amidated

<400> 8
Xaa Ala Asp Gly Ser Phe Ser Asp Glu Xaa Asn Thr Ile Leu Asp Asn 
1               5                   10                  15      


Leu Ala Ala Arg Asp Phe Ile Asn Trp Leu Ile Gln Thr Lys 
            20                  25                  30  


<210> 9
<211> 30
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide


<220>
<221> MOD_RES
<222> (10)..(10)
<223> Nle 

<220>
<223> C-term NH-i-Am

<400> 9
His Gly Asp Gly Ser Phe Ser Asp Glu Xaa Asn Thr Ile Leu Asp Asn 
1               5                   10                  15      


Leu Ala Ala Arg Asp Phe Ile Asn Trp Leu Ile Gln Thr Lys 
            20                  25                  30  


<210> 10
<211> 30
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide


<220>
<221> MOD_RES
<222> (10)..(10)
<223> Nle 

<220>
<223> C-term NH-Et

<400> 10
His Gly Asp Gly Ser Phe Ser Asp Glu Xaa Asn Thr Ile Leu Asp Asn 
1               5                   10                  15      


Leu Ala Ala Arg Asp Phe Ile Asn Trp Leu Ile Gln Thr Lys 
            20                  25                  30  


<210> 11
<211> 30
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide


<220>
<221> MOD_RES
<222> (10)..(10)
<223> Nle 

<220>
<223> C-term NH-Bzl

<400> 11
His Gly Asp Gly Ser Phe Ser Asp Glu Xaa Asn Thr Ile Leu Asp Asn 
1               5                   10                  15      


Leu Ala Ala Arg Asp Phe Ile Asn Trp Leu Ile Gln Thr Lys 
            20                  25                  30  


<210> 12
<211> 30
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide


<220>
<221> MOD_RES
<222> (10)..(10)
<223> Nle 

<220>
<221> MOD_RES
<222> (16)..(16)
<223> D-Phe

<220>
<223> C-term amidated

<400> 12
His Gly Asp Gly Ser Phe Ser Asp Glu Xaa Asn Thr Ile Leu Asp Xaa 
1               5                   10                  15      


Leu Ala Ala Arg Asp Phe Ile Asn Trp Leu Ile Gln Thr Lys 
            20                  25                  30  


<210> 13
<211> 30
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide


<220>
<221> MOD_RES
<222> (10)..(10)
<223> Nle 

<220>
<223> C-term amidated

<400> 13
His Gly Asp Gly Ser Phe Ser Asp Glu Xaa Asn Thr Ile Leu Asp Phe 
1               5                   10                  15      


Leu Ala Ala Arg Asp Phe Ile Asn Trp Leu Ile Gln Thr Lys 
            20                  25                  30  


<210> 14
<211> 30
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide


<220>
<221> MOD_RES
<222> (10)..(10)
<223> Nle 

<220>
<223> C-term NH-i-Am

<400> 14
His Gly Asp Gly Ser Phe Ser Asp Glu Xaa Asn Thr Ile Leu Asp Asn 
1               5                   10                  15      


Leu Ala Ala Arg Asp Phe Ile Asn Trp Leu Ile Arg Thr Lys 
            20                  25                  30  


<210> 15
<211> 30
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide


<220>
<221> MOD_RES
<222> (10)..(10)
<223> Nle 

<220>
<223> C-term amidated

<400> 15
His Gly Asp Gly Ser Phe Ser Asp Glu Xaa Asn Thr Ile Leu Asp Leu 
1               5                   10                  15      


Leu Ala Ala Arg Asp Phe Ile Asn Trp Leu Ile Gln Thr Lys 
            20                  25                  30  


<210> 16
<211> 30
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide


<220>
<221> MOD_RES
<222> (10)..(10)
<223> Nle 

<220>
<221> MOD_RES
<222> (11)..(11)
<223> D-Asn

<220>
<223> C-term NH-i-Am

<400> 16
His Gly Asp Gly Ser Phe Ser Asp Glu Xaa Xaa Thr Ile Leu Asp Asn 
1               5                   10                  15      


Leu Ala Ala Arg Asp Phe Ile Asn Trp Leu Ile Gln Thr Lys 
            20                  25                  30  


<210> 17
<211> 30
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide


<220>
<221> MOD_RES
<222> (10)..(10)
<223> Nle 

<220>
<221> MOD_RES
<222> (11)..(11)
<223> D-Phe

<220>
<223> C-term amidated

<400> 17
His Gly Asp Gly Ser Phe Ser Asp Glu Xaa Xaa Thr Ile Leu Asp Asn 
1               5                   10                  15      


Leu Ala Ala Arg Asp Phe Ile Asn Trp Leu Ile Gln Thr Lys 
            20                  25                  30  


<210> 18
<211> 30
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide


<220>
<221> MOD_RES
<222> (10)..(10)
<223> Nle 

<220>
<223> C-term amidated

<400> 18
His Gly Asp Gly Ser Phe Ser Asp Glu Xaa Phe Thr Ile Leu Asp Asn 
1               5                   10                  15      


Leu Ala Ala Arg Asp Phe Ile Asn Trp Leu Ile Gln Thr Lys 
            20                  25                  30  


<210> 19
<211> 30
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide


<220>
<221> MOD_RES
<222> (10)..(10)
<223> Nle 

<220>
<223> C-term amidated

<400> 19
His Gly Asp Gly Ser Phe Ser Asp Glu Xaa Leu Thr Ile Leu Asp Asn 
1               5                   10                  15      


Leu Ala Ala Arg Asp Phe Ile Asn Trp Leu Ile Gln Thr Lys 
            20                  25                  30  


<210> 20
<211> 30
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide


<220>
<221> MOD_RES
<222> (10)..(10)
<223> Nle 

<220>
<221> MOD_RES
<222> (11)..(11)
<223> D-Leu

<220>
<223> C-term amidated

<400> 20
His Gly Asp Gly Ser Phe Ser Asp Glu Xaa Xaa Thr Ile Leu Asp Asn 
1               5                   10                  15      


Leu Ala Ala Arg Asp Phe Ile Asn Trp Leu Ile Gln Thr Lys 
            20                  25                  30  


<210> 21
<211> 30
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide


<220>
<221> MOD_RES
<222> (10)..(10)
<223> Nle 

<220>
<221> MOD_RES
<222> (16)..(16)
<223> 1-Nal

<220>
<223> C-term amidated

<400> 21
His Gly Asp Gly Ser Phe Ser Asp Glu Xaa Asn Thr Ile Leu Asp Xaa 
1               5                   10                  15      


Leu Ala Ala Arg Asp Phe Ile Asn Trp Leu Ile Gln Thr Lys 
            20                  25                  30  


<210> 22
<211> 30
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide


<220>
<221> MOD_RES
<222> (10)..(10)
<223> Nle 

<220>
<223> C-term amidated

<400> 22
His Gly Asp Gly Ser Phe Ser Asp Glu Xaa Asn Thr Ile Leu Asp Tyr 
1               5                   10                  15      


Leu Ala Ala Arg Asp Phe Ile Asn Trp Leu Ile Gln Thr Lys 
            20                  25                  30  


<210> 23
<211> 30
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide


<220>
<221> MOD_RES
<222> (10)..(10)
<223> Nle 

<220>
<223> C-term amidated

<400> 23
His Gly Asp Gly Ser Phe Ser Asp Glu Xaa Asn Thr Ile Leu Asp His 
1               5                   10                  15      


Leu Ala Ala Arg Asp Phe Ile Asn Trp Leu Ile Gln Thr Lys 
            20                  25                  30  


<210> 24
<211> 30
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide


<220>
<221> MOD_RES
<222> (10)..(10)
<223> Nle 

<220>
<221> MOD_RES
<222> (16)..(16)
<223> 2-Nal

<220>
<223> C-term amidated

<400> 24
His Gly Asp Gly Ser Phe Ser Asp Glu Xaa Asn Thr Ile Leu Asp Xaa 
1               5                   10                  15      


Leu Ala Ala Arg Asp Phe Ile Asn Trp Leu Ile Gln Thr Lys 
            20                  25                  30  


<210> 25
<211> 30
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide


<220>
<221> MOD_RES
<222> (10)..(10)
<223> Nle 

<220>
<221> MOD_RES
<222> (16)..(16)
<223> Thi

<220>
<223> C-term amidated

<400> 25
His Gly Asp Gly Ser Phe Ser Asp Glu Xaa Asn Thr Ile Leu Asp Xaa 
1               5                   10                  15      


Leu Ala Ala Arg Asp Phe Ile Asn Trp Leu Ile Gln Thr Lys 
            20                  25                  30  


<210> 26
<211> 30
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide


<220>
<221> MOD_RES
<222> (10)..(10)
<223> Nle 

<220>
<223> C-term amidated

<400> 26
His Gly Asp Gly Ser Phe Ser Asp Glu Xaa Asn Thr Ile Leu Asp Trp 
1               5                   10                  15      


Leu Ala Ala Arg Asp Phe Ile Asn Trp Leu Ile Gln Thr Lys 
            20                  25                  30  


<210> 27
<211> 30
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide


<220>
<221> MOD_RES
<222> (10)..(10)
<223> Nle 

<220>
<221> MOD_RES
<222> (16)..(16)
<223> Cha

<220>
<223> C-term amidated

<400> 27
His Gly Asp Gly Ser Phe Ser Asp Glu Xaa Asn Thr Ile Leu Asp Xaa 
1               5                   10                  15      


Leu Ala Ala Arg Asp Phe Ile Asn Trp Leu Ile Gln Thr Lys 
            20                  25                  30  


<210> 28
<211> 30
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide


<220>
<221> MOD_RES
<222> (10)..(10)
<223> Nle 

<220>
<221> MOD_RES
<222> (16)..(16)
<223> Aph

<220>
<223> C-term amidated

<400> 28
His Gly Asp Gly Ser Phe Ser Asp Glu Xaa Asn Thr Ile Leu Asp Xaa 
1               5                   10                  15      


Leu Ala Ala Arg Asp Phe Ile Asn Trp Leu Ile Gln Thr Lys 
            20                  25                  30  


<210> 29
<211> 30
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide


<220>
<221> MOD_RES
<222> (10)..(10)
<223> Nle 

<220>
<221> MOD_RES
<222> (16)..(16)
<223> Cpa

<220>
<223> C-term amidated

<400> 29
His Gly Asp Gly Ser Phe Ser Asp Glu Xaa Asn Thr Ile Leu Asp Xaa 
1               5                   10                  15      


Leu Ala Ala Arg Asp Phe Ile Asn Trp Leu Ile Gln Thr Lys 
            20                  25                  30  


<210> 30
<211> 30
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide


<220>
<221> MOD_RES
<222> (10)..(10)
<223> Nle 

<220>
<221> MOD_RES
<222> (16)..(16)
<223> Dip

<220>
<223> C-term amidated

<400> 30
His Gly Asp Gly Ser Phe Ser Asp Glu Xaa Asn Thr Ile Leu Asp Xaa 
1               5                   10                  15      


Leu Ala Ala Arg Asp Phe Ile Asn Trp Leu Ile Gln Thr Lys 
            20                  25                  30  


<210> 31
<211> 30
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide


<220>
<221> MOD_RES
<222> (10)..(10)
<223> Nle 

<220>
<221> MOD_RES
<222> (16)..(16)
<223> Bip

<220>
<223> C-term amidated

<400> 31
His Gly Asp Gly Ser Phe Ser Asp Glu Xaa Asn Thr Ile Leu Asp Xaa 
1               5                   10                  15      


Leu Ala Ala Arg Asp Phe Ile Asn Trp Leu Ile Gln Thr Lys 
            20                  25                  30  


<210> 32
<211> 30
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide


<220>
<221> MOD_RES
<222> (10)..(10)
<223> Nle 

<220>
<221> MOD_RES
<222> (16)..(16)
<223> hPhe

<220>
<223> C-term amidated

<400> 32
His Gly Asp Gly Ser Phe Ser Asp Glu Xaa Asn Thr Ile Leu Asp Xaa 
1               5                   10                  15      


Leu Ala Ala Arg Asp Phe Ile Asn Trp Leu Ile Gln Thr Lys 
            20                  25                  30  


<210> 33
<211> 30
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide


<220>
<221> MOD_RES
<222> (10)..(10)
<223> Nle 

<220>
<221> MOD_RES
<222> (11)..(11)
<223> D-Cpa

<220>
<223> C-term amidated

<400> 33
His Gly Asp Gly Ser Phe Ser Asp Glu Xaa Xaa Thr Ile Leu Asp Asn 
1               5                   10                  15      


Leu Ala Ala Arg Asp Phe Ile Asn Trp Leu Ile Gln Thr Lys 
            20                  25                  30  


<210> 34
<211> 30
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide


<220>
<221> MOD_RES
<222> (10)..(10)
<223> Nle 

<220>
<221> MOD_RES
<222> (11)..(11)
<223> D-Trp

<220>
<223> C-term amidated

<400> 34
His Gly Asp Gly Ser Phe Ser Asp Glu Xaa Xaa Thr Ile Leu Asp Asn 
1               5                   10                  15      


Leu Ala Ala Arg Asp Phe Ile Asn Trp Leu Ile Gln Thr Lys 
            20                  25                  30  


<210> 35
<211> 30
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide


<220>
<221> MOD_RES
<222> (10)..(10)
<223> Nle 

<220>
<223> C-term amidated

<400> 35
His Gly Asp Gly Ser Phe Ser Asp Glu Xaa Ile Thr Ile Leu Asp Asn 
1               5                   10                  15      


Leu Ala Ala Arg Asp Phe Ile Asn Trp Leu Ile Gln Thr Lys 
            20                  25                  30  


<210> 36
<211> 30
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide


<220>
<221> MOD_RES
<222> (10)..(10)
<223> Nle 

<220>
<221> MOD_RES
<222> (11)..(11)
<223> D-Thi

<220>
<223> C-term amidated

<400> 36
His Gly Asp Gly Ser Phe Ser Asp Glu Xaa Xaa Thr Ile Leu Asp Asn 
1               5                   10                  15      


Leu Ala Ala Arg Asp Phe Ile Asn Trp Leu Ile Gln Thr Lys 
            20                  25                  30  


<210> 37
<211> 30
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide


<220>
<221> MOD_RES
<222> (10)..(10)
<223> Nle 

<220>
<221> MOD_RES
<222> (11)..(11)
<223> Cpa

<220>
<223> C-term amidated

<400> 37
His Gly Asp Gly Ser Phe Ser Asp Glu Xaa Xaa Thr Ile Leu Asp Asn 
1               5                   10                  15      


Leu Ala Ala Arg Asp Phe Ile Asn Trp Leu Ile Gln Thr Lys 
            20                  25                  30  


<210> 38
<211> 30
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide


<220>
<221> MOD_RES
<222> (10)..(10)
<223> Nle 

<220>
<223> C-term amidated

<400> 38
His Gly Asp Gly Ser Phe Ser Asp Glu Xaa His Thr Ile Leu Asp Asn 
1               5                   10                  15      


Leu Ala Ala Arg Asp Phe Ile Asn Trp Leu Ile Gln Thr Lys 
            20                  25                  30  


<210> 39
<211> 30
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide


<220>
<221> MOD_RES
<222> (10)..(10)
<223> Nle 

<220>
<221> MOD_RES
<222> (11)..(11)
<223> D-His

<220>
<223> C-term amidated

<400> 39
His Gly Asp Gly Ser Phe Ser Asp Glu Xaa Xaa Thr Ile Leu Asp Asn 
1               5                   10                  15      


Leu Ala Ala Arg Asp Phe Ile Asn Trp Leu Ile Gln Thr Lys 
            20                  25                  30  


<210> 40
<211> 30
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide


<220>
<221> MOD_RES
<222> (10)..(10)
<223> Nle 

<220>
<221> MOD_RES
<222> (11)..(11)
<223> Cha

<220>
<223> C-term amidated

<400> 40
His Gly Asp Gly Ser Phe Ser Asp Glu Xaa Xaa Thr Ile Leu Asp Asn 
1               5                   10                  15      


Leu Ala Ala Arg Asp Phe Ile Asn Trp Leu Ile Gln Thr Lys 
            20                  25                  30  


<210> 41
<211> 30
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide


<220>
<221> MOD_RES
<222> (10)..(10)
<223> Nle 

<220>
<221> MOD_RES
<222> (11)..(11)
<223> Hol

<220>
<223> C-term amidated

<400> 41
His Gly Asp Gly Ser Phe Ser Asp Glu Xaa Xaa Thr Ile Leu Asp Asn 
1               5                   10                  15      


Leu Ala Ala Arg Asp Phe Ile Asn Trp Leu Ile Gln Thr Lys 
            20                  25                  30  


<210> 42
<211> 30
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide


<220>
<221> MOD_RES
<222> (10)..(10)
<223> Nle 

<220>
<221> MOD_RES
<222> (11)..(11)
<223> Bip

<220>
<223> C-term amidated

<400> 42
His Gly Asp Gly Ser Phe Ser Asp Glu Xaa Xaa Thr Ile Leu Asp Asn 
1               5                   10                  15      


Leu Ala Ala Arg Asp Phe Ile Asn Trp Leu Ile Gln Thr Lys 
            20                  25                  30  


<210> 43
<211> 30
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide


<220>
<221> MOD_RES
<222> (10)..(10)
<223> Nle 

<220>
<221> MOD_RES
<222> (11)..(11)
<223> D-Tyr

<220>
<223> C-term amidated

<400> 43
His Gly Asp Gly Ser Phe Ser Asp Glu Xaa Xaa Thr Ile Leu Asp Asn 
1               5                   10                  15      


Leu Ala Ala Arg Asp Phe Ile Asn Trp Leu Ile Gln Thr Lys 
            20                  25                  30  


<210> 44
<211> 30
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide


<220>
<221> MOD_RES
<222> (10)..(10)
<223> Nle 

<220>
<221> MOD_RES
<222> (11)..(11)
<223> D-2-Cpa

<220>
<223> C-term amidated

<400> 44
His Gly Asp Gly Ser Phe Ser Asp Glu Xaa Xaa Thr Ile Leu Asp Asn 
1               5                   10                  15      


Leu Ala Ala Arg Asp Phe Ile Asn Trp Leu Ile Gln Thr Lys 
            20                  25                  30  


<210> 45
<211> 30
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide


<220>
<221> MOD_RES
<222> (10)..(10)
<223> Nle 

<220>
<221> MOD_RES
<222> (11)..(11)
<223> D-Fpa

<220>
<223> C-term amidated

<400> 45
His Gly Asp Gly Ser Phe Ser Asp Glu Xaa Xaa Thr Ile Leu Asp Asn 
1               5                   10                  15      


Leu Ala Ala Arg Asp Phe Ile Asn Trp Leu Ile Gln Thr Lys 
            20                  25                  30  


<210> 46
<211> 30
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide


<220>
<221> MOD_RES
<222> (10)..(10)
<223> Nle 

<220>
<221> MOD_RES
<222> (11)..(11)
<223> D-3-Thi

<220>
<223> C-term amidated

<400> 46
His Gly Asp Gly Ser Phe Ser Asp Glu Xaa Xaa Thr Ile Leu Asp Asn 
1               5                   10                  15      


Leu Ala Ala Arg Asp Phe Ile Asn Trp Leu Ile Gln Thr Lys 
            20                  25                  30  


<210> 47
<211> 30
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide


<220>
<221> MOD_RES
<222> (10)..(10)
<223> Nle 

<220>
<221> MOD_RES
<222> (11)..(11)
<223> D-FurAla

<220>
<223> C-term amidated

<400> 47
His Gly Asp Gly Ser Phe Ser Asp Glu Xaa Xaa Thr Ile Leu Asp Asn 
1               5                   10                  15      


Leu Ala Ala Arg Asp Phe Ile Asn Trp Leu Ile Gln Thr Lys 
            20                  25                  30  


<210> 48
<211> 30
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide


<220>
<221> MOD_RES
<222> (10)..(10)
<223> Nle 

<220>
<221> MOD_RES
<222> (11)..(11)
<223> D-3-Cpa

<220>
<223> C-term amidated

<400> 48
His Gly Asp Gly Ser Phe Ser Asp Glu Xaa Xaa Thr Ile Leu Asp Asn 
1               5                   10                  15      


Leu Ala Ala Arg Asp Phe Ile Asn Trp Leu Ile Gln Thr Lys 
            20                  25                  30  


<210> 49
<211> 30
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide


<220>
<221> MOD_RES
<222> (10)..(10)
<223> Nle 

<220>
<221> MOD_RES
<222> (11)..(11)
<223> D-Thi

<220>
<223> C-term amidated

<400> 49
His Gly Asp Gly Ser Phe Ser Asp Glu Xaa Xaa Thr Ile Leu Asp Leu 
1               5                   10                  15      


Leu Ala Ala Arg Asp Phe Ile Asn Trp Leu Ile Gln Thr Lys 
            20                  25                  30  


<210> 50
<211> 30
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide


<220>
<221> MOD_RES
<222> (10)..(10)
<223> Nle 

<220>
<221> MOD_RES
<222> (11)..(11)
<223> D-Thi

<220>
<223> C-term amidated

<400> 50
His Gly Asp Gly Ser Phe Ser Asp Glu Xaa Xaa Thr Ile Leu Asp Phe 
1               5                   10                  15      


Leu Ala Ala Arg Asp Phe Ile Asn Trp Leu Ile Gln Thr Lys 
            20                  25                  30  


<210> 51
<211> 30
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide


<220>
<221> MOD_RES
<222> (10)..(10)
<223> Nle 

<220>
<221> MOD_RES
<222> (11)..(11)
<223> D-Phe

<220>
<223> C-term amidated

<400> 51
His Gly Asp Gly Ser Phe Ser Asp Glu Xaa Xaa Thr Ile Leu Asp Phe 
1               5                   10                  15      


Leu Ala Ala Arg Asp Phe Ile Asn Trp Leu Ile Gln Thr Lys 
            20                  25                  30  


<210> 52
<211> 30
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide


<220>
<221> MOD_RES
<222> (10)..(10)
<223> Nle 

<220>
<221> MOD_RES
<222> (11)..(11)
<223> D-Phe

<220>
<223> C-term amidated

<400> 52
His Gly Asp Gly Ser Phe Ser Asp Glu Xaa Xaa Thr Ile Leu Asp Leu 
1               5                   10                  15      


Leu Ala Ala Arg Asp Phe Ile Asn Trp Leu Ile Gln Thr Lys 
            20                  25                  30  


<210> 53
<211> 30
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide


<220>
<221> MOD_RES
<222> (10)..(10)
<223> Nle 

<220>
<221> MOD_RES
<222> (11)..(11)
<223> D-Phe

<220>
<223> C-term amidated

<400> 53
His Gly Asp Gly Ser Phe Ser Asp Glu Xaa Xaa Thr Ile Leu Asp Tyr 
1               5                   10                  15      


Leu Ala Ala Arg Asp Phe Ile Asn Trp Leu Ile Gln Thr Lys 
            20                  25                  30  


<210> 54
<211> 30
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide


<220>
<221> MOD_RES
<222> (10)..(10)
<223> Nle 

<220>
<221> MOD_RES
<222> (11)..(11)
<223> D-Thi

<220>
<223> C-term amidated

<400> 54
His Gly Asp Gly Ser Phe Ser Asp Glu Xaa Xaa Thr Ile Leu Asp Tyr 
1               5                   10                  15      


Leu Ala Ala Arg Asp Phe Ile Asn Trp Leu Ile Gln Thr Lys 
            20                  25                  30  


<210> 55
<211> 33
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide


<220>
<221> MOD_RES
<222> (10)..(10)
<223> Nle 

<220>
<221> MOD_RES
<222> (11)..(11)
<223> D-Phe

<220>
<223> C-term amidated

<400> 55
His Gly Asp Gly Ser Phe Ser Asp Glu Xaa Xaa Thr Ile Leu Asp Leu 
1               5                   10                  15      


Leu Ala Ala Arg Asp Phe Ile Asn Trp Leu Ile Gln Thr Lys Ile Thr
            20                  25                  30  

Asp



<210> 56
<211> 30
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide


<220>
<221> MOD_RES
<222> (10)..(10)
<223> Nle 

<220>
<221> MOD_RES
<222> (11)..(11)
<223> D-Phe

<220>
<223> C-term amidated

<400> 56
His Gly Asp Gly Ser Phe Ser Asp Glu Xaa Xaa Thr Ile Leu Asp Leu 
1               5                   10                  15      


Leu Ala Thr Arg Asp Phe Ile Asn Trp Leu Ile Gln Thr Lys 
            20                  25                  30  


<210> 57
<211> 33
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide


<220>
<221> MOD_RES
<222> (10)..(10)
<223> Nle 

<220>
<221> MOD_RES
<222> (11)..(11)
<223> D-Phe

<220>
<223> C-term NHEt

<400> 57
His Gly Asp Gly Ser Phe Ser Asp Glu Xaa Xaa Thr Ile Leu Asp Leu 
1               5                   10                  15      


Leu Ala Ala Arg Asp Phe Ile Asn Trp Leu Ile Gln Thr Lys Ile Thr
            20                  25                  30  

Asp



<210> 58
<211> 33
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide


<220>
<221> MOD_RES
<222> (10)..(10)
<223> Nle 

<220>
<221> MOD_RES
<222> (11)..(11)
<223> D-Phe

<220>
<223> C-term NH-4-Pic

<400> 58
His Gly Asp Gly Ser Phe Ser Asp Glu Xaa Xaa Thr Ile Leu Asp Leu 
1               5                   10                  15      


Leu Ala Ala Arg Asp Phe Ile Asn Trp Leu Ile Gln Thr Lys Ile Thr
            20                  25                  30  

Asp



<210> 59
<211> 33
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide


<220>
<221> MOD_RES
<222> (10)..(10)
<223> Nle 

<220>
<221> MOD_RES
<222> (11)..(11)
<223> D-Phe

<220>
<223> C-term NH-((CH2)2O)4-(CH2)2-C(O)-NH2

<400> 59
His Gly Asp Gly Ser Phe Ser Asp Glu Xaa Xaa Thr Ile Leu Asp Leu 
1               5                   10                  15      


Leu Ala Ala Arg Asp Phe Ile Asn Trp Leu Ile Gln Thr Lys Ile Thr
            20                  25                  30  

Asp


<210> 60
<211> 33
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide


<220>
<221> MOD_RES
<222> (10)..(10)
<223> Nle 

<220>
<221> MOD_RES
<222> (11)..(11)
<223> D-Phe

<220>
<223> C-term NH-CH2-((CH2)2O)3-(CH2)3-NHC(O)-CH2-O-CH2-C(O)-NH2

<400> 60
His Gly Asp Gly Ser Phe Ser Asp Glu Xaa Xaa Thr Ile Leu Asp Leu 
1               5                   10                  15      


Leu Ala Ala Arg Asp Phe Ile Asn Trp Leu Ile Gln Thr Lys Ile Thr
            20                  25                  30  

Asp



<210> 61
<211> 33
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide


<220>
<221> MOD_RES
<222> (10)..(10)
<223> Nle 

<220>
<221> MOD_RES
<222> (11)..(11)
<223> D-Phe

<220>
<223> C-term NH-isobutyl

<400> 61
His Gly Asp Gly Ser Phe Ser Asp Glu Xaa Xaa Thr Ile Leu Asp Leu 
1               5                   10                  15      


Leu Ala Ala Arg Asp Phe Ile Asn Trp Leu Ile Gln Thr Lys Ile Thr
            20                  25                  30  

Asp



<210> 62
<211> 33
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide


<220>
<221> MOD_RES
<222> (10)..(10)
<223> Nle 

<220>
<221> MOD_RES
<222> (11)..(11)
<223> D-Phe

<220>
<223> C-term NH-Benzyl

<400> 62
His Gly Asp Gly Ser Phe Ser Asp Glu Xaa Xaa Thr Ile Leu Asp Leu 
1               5                   10                  15      


Leu Ala Ala Arg Asp Phe Ile Asn Trp Leu Ile Gln Thr Lys Ile Thr
            20                  25                  30  

Asp



<210> 63
<211> 33
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide


<220>
<221> MOD_RES
<222> (10)..(10)
<223> Nle 

<220>
<221> MOD_RES
<222> (11)..(11)
<223> D-Phe

<220>
<223> C-term OH

<400> 63
His Gly Asp Gly Ser Phe Ser Asp Glu Xaa Xaa Thr Ile Leu Asp Leu 
1               5                   10                  15      


Leu Ala Ala Arg Asp Phe Ile Asn Trp Leu Ile Gln Thr Lys Ile Thr
            20                  25                  30  

Asp



<210> 64
<211> 33
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide


<220>
<221> MOD_RES
<222> (10)..(10)
<223> Nle 

<220>
<221> MOD_RES
<222> (11)..(11)
<223> D-Phe

<220>
<223> C-term NH-CH2-((CH2)2O)3-(CH2)3-NH-C(O)-CH2-O-CH2-C(O)-NH2

<400> 64
His Gly Asp Gly Ser Phe Ser Asp Glu Xaa Xaa Thr Ile Leu Asp Phe 
1               5                   10                  15      


Leu Ala Ala Arg Asp Phe Ile Asn Trp Leu Ile Gln Thr Lys Ile Thr
            20                  25                  30  

Asp



<210> 65
<211> 33
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide


<220>
<221> MOD_RES
<222> (10)..(10)
<223> Nle 

<220>
<221> MOD_RES
<222> (11)..(11)
<223> D-Phe

<220>
<223> C-term NH-CH2-((CH2)2O)3-(CH2)3-NH-C(O)-CH2-O-CH2-C(O)-NH-
      ((CH2)2O)6-(CH2)2-C(O)-NH2

<400> 65
His Gly Asp Gly Ser Phe Ser Asp Glu Xaa Xaa Thr Ile Leu Asp Phe 
1               5                   10                  15      


Leu Ala Ala Arg Asp Phe Ile Asn Trp Leu Ile Gln Thr Lys Ile Thr
            20                  25                  30  

Asp



<210> 66
<211> 33
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide


<220>
<221> MOD_RES
<222> (10)..(10)
<223> Nle 

<220>
<221> MOD_RES
<222> (11)..(11)
<223> D-Thi

<220>
<223> C-term amidated

<400> 66
His Gly Asp Gly Ser Phe Ser Asp Glu Xaa Xaa Thr Ile Leu Asp Leu 
1               5                   10                  15      


Leu Ala Thr Arg Asp Phe Ile Asn Trp Leu Ile Gln Thr Lys Ile Thr
            20                  25                  30  

Asp



<210> 67
<211> 33
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide


<220>
<221> MOD_RES
<222> (10)..(10)
<223> Nle 

<220>
<221> MOD_RES
<222> (11)..(11)
<223> D-Phe

<220>
<223> C-term amidated

<400> 67
His Gly Asp Gly Ser Phe Ser Asp Glu Xaa Xaa Thr Ile Leu Asp Phe 
1               5                   10                  15      


Leu Ala Ala Arg Asp Phe Ile Asn Trp Leu Ile Gln Thr Lys Ile Thr
            20                  25                  30  

Asp



<210> 68
<211> 33
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide


<220>
<221> MOD_RES
<222> (10)..(10)
<223> Nle 

<220>
<221> MOD_RES
<222> (11)..(11)
<223> D-Phe

<220>
<223> C-term OH

<400> 68
His Gly Asp Gly Ser Phe Ser Asp Glu Xaa Xaa Thr Ile Leu Asp Phe 
1               5                   10                  15      


Leu Ala Ala Arg Asp Phe Ile Asn Trp Leu Ile Gln Thr Lys Ile Thr
            20                  25                  30  

Asp



<210> 69
<211> 33
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide


<220>
<221> MOD_RES
<222> (10)..(10)
<223> Nle 

<220>
<221> MOD_RES
<222> (11)..(11)
<223> D-3-Cpa

<220>
<221> MOD_RES
<222> (16)..(16)
<223> 2-Nal

<220>
<223> C-term amidated

<400> 69
His Gly Asp Gly Ser Phe Ser Asp Glu Xaa Xaa Thr Ile Leu Asp Xaa 
1               5                   10                  15      


Leu Ala Ala Arg Asp Phe Ile Asn Trp Leu Ile Gln Thr Lys Ile Thr
            20                  25                  30  

Asp



<210> 70
<211> 33
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide


<220>
<221> MOD_RES
<222> (10)..(10)
<223> Nle 

<220>
<221> MOD_RES
<222> (11)..(11)
<223> D-3-Cpa

<220>
<223> C-term amidated

<400> 70
His Gly Asp Gly Ser Phe Ser Asp Glu Xaa Xaa Thr Ile Leu Asp Phe 
1               5                   10                  15      


Leu Ala Ala Arg Asp Phe Ile Asn Trp Leu Ile Gln Thr Lys Ile Thr
            20                  25                  30  

Asp



<210> 71
<211> 33
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide


<220>
<221> MOD_RES
<222> (10)..(10)
<223> Nle 

<220>
<221> MOD_RES
<222> (11)..(11)
<223> D-3-Cpa

<220>
<223> C-term amidated

<400> 71
His Gly Asp Gly Ser Phe Ser Asp Glu Xaa Xaa Thr Ile Leu Asp Leu 
1               5                   10                  15      


Leu Ala Ala Arg Asp Phe Ile Asn Trp Leu Ile Gln Thr Lys Ile Thr
            20                  25                  30  

Asp



<210> 72
<211> 33
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide


<220>
<221> MOD_RES
<222> (10)..(10)
<223> Nle 

<220>
<221> MOD_RES
<222> (11)..(11)
<223> D-Thi

<220>
<223> C-term amidated

<400> 72
His Gly Asp Gly Ser Phe Ser Asp Glu Xaa Xaa Thr Ile Leu Asp Phe 
1               5                   10                  15      


Leu Ala Ala Arg Asp Phe Ile Asn Trp Leu Ile Gln Thr Lys Ile Thr
            20                  25                  30  

Asp



<210> 73
<211> 33
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide


<220>
<221> MOD_RES
<222> (4)..(4)
<223> D-Ala

<220>
<221> MOD_RES
<222> (10)..(10)
<223> Nle 

<220>
<221> MOD_RES
<222> (11)..(11)
<223> D-Phe

<220>
<223> C-term amidated

<400> 73
His Gly Asp Xaa Ser Phe Ser Asp Glu Xaa Xaa Thr Ile Leu Asp Leu 
1               5                   10                  15      


Leu Ala Ala Arg Asp Phe Ile Asn Trp Leu Ile Gln Thr Lys Ile Thr
            20                  25                  30  

Asp



<210> 74
<211> 33
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide


<220>
<221> MOD_RES
<222> (1)..(1)
<223> EtHis

<220>
<221> MOD_RES
<222> (4)..(4)
<223> D-Ala

<220>
<221> MOD_RES
<222> (10)..(10)
<223> Nle 

<220>
<221> MOD_RES
<222> (11)..(11)
<223> D-Phe

<220>
<223> C-term amidated

<400> 74
Xaa Ala Asp Xaa Ser Phe Ser Asp Glu Xaa Xaa Thr Ile Leu Asp Leu 
1               5                   10                  15      


Leu Ala Ala Arg Asp Phe Ile Asn Trp Leu Ile Gln Thr Lys Ile Thr
            20                  25                  30  

Asp



