                         SEQUENCE LISTING



<110> Kenneth, Wild

      Treanor, James

      Huang, Haichun

      Inoue, Heather

      Zhang, Tie J. 

      Martin, Frank



<120>  Human anti-NGF Neutralizing Antibodies as Selective NGF Pathway Inhibitors



<130>  02-1240



<150>  US 60/487,431

<151>  2003-07-15



<160>  138   



<170>  PatentIn version 3.0



<210>  1

<211>  990

<212>  DNA

<213>  Homo sapiens



<400>  1
gcctccacca agggcccatc ggtcttcccc ctggcaccct cctccaagag cacctctggg     60

ggcacagcgg ccctgggctg cctggtcaag gactacttcc ccgaaccggt gacggtgtcg    120

tggaactcag gcgccctgac cagcggcgtg cacaccttcc cggctgtcct acagtcctca    180

ggactctact ccctcagcag cgtggtgacc gtgccctcca gcagcttggg cacccagacc    240

tacatctgca acgtgaatca caagcccagc aacaccaagg tggacaagaa agttgagccc    300

aaatcttgtg acaaaactca cacatgccca ccgtgcccag cacctgaact cctgggggga    360

ccgtcagtct tcctcttccc cccaaaaccc aaggacaccc tcatgatctc ccggacccct    420

gaggtcacat gcgtggtggt ggacgtgagc cacgaagacc ctgaggtcaa gttcaactgg    480

tacgtggacg gcgtggaggt gcataatgcc aagacaaagc cgcgggagga gcagtacaac    540

agcacgtacc gtgtggtcag cgtcctcacc gtcctgcacc aggactggct gaatggcaag    600

gagtacaagt gcaaggtctc caacaaagcc ctcccagccc ccatcgagaa aaccatctcc    660

aaagccaaag ggcagccccg agaaccacag gtgtacaccc tgcccccatc ccgggatgag    720

ctgaccaaga accaggtcag cctgacctgc ctggtcaaag gcttctatcc cagcgacatc    780

gccgtggagt gggagagcaa tgggcagccg gagaacaact acaagaccac gcctcccgtg    840

ctggactccg acggctcctt cttcctctat agcaagctca ccgtggacaa gagcaggtgg    900

cagcagggga acgtcttctc atgctccgtg atgcatgagg ctctgcacaa ccactacacg    960

cagaagagcc tctccctgtc tccgggtaaa                                     990


<210>  2

<211>  330

<212>  PRT

<213>  Homo sapiens



<400>  2

Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys 
1               5                   10                  15      

Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          

Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              

Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  

Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr 
65                  70                  75                  80  

Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      

Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys 
            100                 105                 110         

Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro 
        115                 120                 125             

Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 
    130                 135                 140                 

Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp 
145                 150                 155                 160 

Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 
                165                 170                 175     

Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 
            180                 185                 190         

His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 
        195                 200                 205             

Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 
    210                 215                 220                 

Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu 
225                 230                 235                 240 

Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr 
                245                 250                 255     

Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 
            260                 265                 270         

Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 
        275                 280                 285             

Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn 
    290                 295                 300                 

Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 
305                 310                 315                 320 

Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
                325                 330 

<210>  3

<211>  978

<212>  DNA

<213>  Homo sapiens



<400>  3
gcctccacca agggcccatc ggtcttcccc ctggcgccct gctccaggag cacctccgag     60

agcacagcgg ccctgggctg cctggtcaag gactacttcc ccgaaccggt gacggtgtcg    120

tggaactcag gcgctctgac cagcggcgtg cacaccttcc cagctgtcct acagtcctca    180

ggactctact ccctcagcag cgtggtgacc gtgccctcca gcaacttcgg cacccagacc    240

tacacctgca acgtagatca caagcccagc aacaccaagg tggacaagac agttgagcgc    300

aaatgttgtg tcgagtgccc accgtgccca gcaccacctg tggcaggacc gtcagtcttc    360

ctcttccccc caaaacccaa ggacaccctc atgatctccc ggacccctga ggtcacgtgc    420

gtggtggtgg acgtgagcca cgaagacccc gaggtccagt tcaactggta cgtggacggc    480

gtggaggtgc ataatgccaa gacaaagcca cgggaggagc agttcaacag cacgttccgt    540

gtggtcagcg tcctcaccgt tgtgcaccag gactggctga acggcaagga gtacaagtgc    600

aaggtctcca acaaaggcct cccagccccc atcgagaaaa ccatctccaa aaccaaaggg    660

cagccccgag aaccacaggt gtacaccctg cccccatccc gggaggagat gaccaagaac    720

caggtcagcc tgacctgcct ggtcaaaggc ttctacccca gcgacatcgc cgtggagtgg    780

gagagcaatg ggcagccgga gaacaactac aagaccacac ctcccatgct ggactccgac    840

ggctccttct tcctctacag caagctcacc gtggacaaga gcaggtggca gcaggggaac    900

gtcttctcat gctccgtgat gcatgaggct ctgcacaacc actacacgca gaagagcctc    960

tccctgtctc cgggtaaa                                                  978


<210>  4

<211>  326

<212>  PRT

<213>  Homo sapiens



<400>  4

Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Cys Ser Arg 
1               5                   10                  15      

Ser Thr Ser Glu Ser Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          

Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              

Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  

Leu Ser Ser Val Val Thr Val Pro Ser Ser Asn Phe Gly Thr Gln Thr 
65                  70                  75                  80  

Tyr Thr Cys Asn Val Asp His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      

Thr Val Glu Arg Lys Cys Cys Val Glu Cys Pro Pro Cys Pro Ala Pro 
            100                 105                 110         

Pro Val Ala Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp 
        115                 120                 125             

Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp 
    130                 135                 140                 

Val Ser His Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly 
145                 150                 155                 160 

Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn 
                165                 170                 175     

Ser Thr Phe Arg Val Val Ser Val Leu Thr Val Val His Gln Asp Trp 
            180                 185                 190         

Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro 
        195                 200                 205             

Ala Pro Ile Glu Lys Thr Ile Ser Lys Thr Lys Gly Gln Pro Arg Glu 
    210                 215                 220                 

Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn 
225                 230                 235                 240 

Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile 
                245                 250                 255     

Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr 
            260                 265                 270         

Thr Pro Pro Met Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys 
        275                 280                 285             

Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys 
    290                 295                 300                 

Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu 
305                 310                 315                 320 

Ser Leu Ser Pro Gly Lys 
                325     

<210>  5

<211>  981

<212>  DNA

<213>  Homo sapiens



<400>  5
gccagcacca aggggccatc cgtcttcccc ctggcgccct gctccaggag cacctccgag     60


agcacagccg ccctgggctg cctggtcaag gactacttcc ccgaaccggt gacggtgtcg    120

tggaactcag gcgccctgac cagcggcgtg cacaccttcc cggctgtcct acagtcctca    180

ggactctact ccctcagcag cgtggtgacc gtgccctcca gcagcttggg cacgaagacc    240

tacacctgca acgtagatca caagcccagc aacaccaagg tggacaagag agttgagtcc    300

aaatatggtc ccccatgccc atcatgccca gcacctgagt tcctgggggg accatcagtc    360

ttcctgttcc ccccaaaacc caaggacact ctcatgatct cccggacccc tgaggtcacg    420

tgcgtggtgg tggacgtgag ccaggaagac cccgaggtcc agttcaactg gtacgtggat    480

ggcgtggagg tgcataatgc caagacaaag ccgcgggagg agcagttcaa cagcacgtac    540

cgtgtggtca gcgtcctcac cgtcctgcac caggactggc tgaacggcaa ggagtacaag    600

tgcaaggtct ccaacaaagg cctcccgtcc tccatcgaga aaaccatctc caaagccaaa    660

gggcagcccc gagagccaca ggtgtacacc ctgcccccat cccaggagga gatgaccaag    720

aaccaggtca gcctgacctg cctggtcaaa ggcttctacc ccagcgacat cgccgtggag    780

tgggagagca atgggcagcc ggagaacaac tacaagacca cgcctcccgt gctggactcc    840

gacggctcct tcttcctcta cagcaggcta accgtgraca agagcaggtg gcaggagggg    900

aatgtcttct catgctccgt gakgcatgag gctctgcaca accactacac acagaagagc    960

ctctccctgt ctctgggtaa a                                              981


<210>  6

<211>  327

<212>  PRT

<213>  Homo sapiens



<400>  6

Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Cys Ser Arg 
1               5                   10                  15      

Ser Thr Ser Glu Ser Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          

Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              

Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  

Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Lys Thr 
65                  70                  75                  80  

Tyr Thr Cys Asn Val Asp His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      

Arg Val Glu Ser Lys Tyr Gly Pro Pro Cys Pro Ser Cys Pro Ala Pro 
            100                 105                 110         

Glu Phe Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys 
        115                 120                 125             

Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val 
    130                 135                 140                 

Asp Val Ser Gln Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp 
145                 150                 155                 160 

Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe 
                165                 170                 175     

Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp 
            180                 185                 190         

Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu 
        195                 200                 205             

Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg 
    210                 215                 220                 

Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Gln Glu Glu Met Thr Lys 
225                 230                 235                 240 

Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp 
                245                 250                 255     

Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys 
            260                 265                 270         

Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser 
        275                 280                 285             

Arg Leu Thr Val Asp Lys Ser Arg Trp Gln Glu Gly Asn Val Phe Ser 
    290                 295                 300                 

Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser 
305                 310                 315                 320 

Leu Ser Leu Ser Leu Gly Lys 
                325         

<210>  7

<211>  321

<212>  DNA

<213>  Homo sapiens



<400>  7
cgaactgtgg ctgcaccatc tgtcttcatc ttcccgccat ctgatgagca gttgaaatct     60

ggaactgcct ctgttgtgtg cctgctgaat aacttctatc ccagagaggc caaagtacag    120

tggaaggtgg ataacgccct ccaatcgggt aactcccagg agagtgtcac agagcaggac    180

agcaaggaca gcacctacag cctcagcagc accctgacgc tgagcaaagc agactacgag    240

aaacacaaag tctacgcctg cgaagtcacc catcagggcc tgagctcgcc cgtcacaaag    300

agcttcaaca ggggagagtg t                                              321


<210>  8

<211>  107

<212>  PRT

<213>  Homo sapiens



<400>  8

Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu 
1               5                   10                  15      

Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe 
            20                  25                  30          

Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln 
        35                  40                  45              

Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser 
    50                  55                  60                  

Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu 
65                  70                  75                  80  

Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser 
                85                  90                  95      

Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
            100                 105         

<210>  9

<211>  369

<212>  DNA

<213>  Homo sapiens



<400>  9
gaggtgcagc tggtggagtc tgggggaggc ttggtacagc ctggggggtc cctgagactc     60

tcctgtgcag cctctggctt caccttaaga agttatagca tgaactgggt tcgccaggct    120

ccagggaagg ggctggagtg ggtttcatac attagtcgta gtagtcatac catattctac    180

gcagactctg tgaagggccg attcaccatc tccagagaca atgccaagaa ttcactgtat    240

ctgcaaatgg acagcctgag agacgaggac acggctatgt attactgtgc gagagtatat    300

agcagtggct ggcacgtctc tgattatttt gactactggg gccagggaat cctggtcacc    360

gtttcctca                                                            369


<210>  10

<211>  123

<212>  PRT

<213>  Homo sapiens



<400>  10

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      

Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Leu Arg Ser Tyr 
            20                  25                  30          

Ser Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              

Ser Tyr Ile Ser Arg Ser Ser His Thr Ile Phe Tyr Ala Asp Ser Val 
    50                  55                  60                  

Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  

Leu Gln Met Asp Ser Leu Arg Asp Glu Asp Thr Ala Met Tyr Tyr Cys 
                85                  90                  95      

Ala Arg Val Tyr Ser Ser Gly Trp His Val Ser Asp Tyr Phe Asp Tyr 
            100                 105                 110         

Trp Gly Gln Gly Ile Leu Val Thr Val Ser Ser 
        115                 120             

<210>  11

<211>  321

<212>  DNA

<213>  Homo sapiens



<400>  11
gccatccagt tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga cagagtcacc     60

atcacttgcc gggcaagtca gggcattagc agtgctttag cctggtatca gcagaaacca    120

gggaaagctc ctaagctcct gatctatgat gcctccagtt tggaaagtgg ggtcccatca    180

aggttcagcg gcagtggatc tgggacagat ttcactctca ccatcagcag cctgcagcct    240

gaagattttg caacttatta ctgtcaacag tttaatagtt acccgctcac tttcggcgga    300

gggaccaagg tggagatcaa a                                              321


<210>  12

<211>  107

<212>  PRT

<213>  Homo sapiens



<400>  12

Ala Ile Gln Leu Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      

Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Ser Ser Ala 
            20                  25                  30          

Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              

Tyr Asp Ala Ser Ser Leu Glu Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  

Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  

Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Phe Asn Ser Tyr Pro Leu 
                85                  90                  95      

Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105         

<210>  13

<211>  42

<212>  DNA

<213>  Homo sapiens



<400>  13
gtatatagca gtggctggca cgtctctgat tattttgact ac                        42


<210>  14

<211>  14

<212>  PRT

<213>  Homo sapiens



<400>  14

Val Tyr Ser Ser Gly Trp His Val Ser Asp Tyr Phe Asp Tyr 
1               5                   10                  

<210>  15

<211>  27

<212>  DNA

<213>  Homo sapiens



<400>  15
caacagttta atagttaccc gctcact                                         27


<210>  16

<211>  9

<212>  PRT

<213>  Homo sapiens



<400>  16

Gln Gln Phe Asn Ser Tyr Pro Leu Thr 
1               5                   

<210>  17

<211>  51

<212>  DNA

<213>  Homo sapiens



<400>  17
tacattagtc gtagtagtca taccatattc tacgcagact ctgtgaaggg c              51


<210>  18

<211>  17

<212>  PRT

<213>  Homo sapiens



<400>  18

Tyr Ile Ser Arg Ser Ser His Thr Ile Phe Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      

Gly 
    

<210>  19

<211>  21

<212>  DNA

<213>  Homo sapiens



<400>  19
gatgcctcca gtttggaaag t                                               21


<210>  20

<211>  7

<212>  PRT

<213>  Homo sapiens



<400>  20

Asp Ala Ser Ser Leu Glu Ser 
1               5           

<210>  21

<211>  15

<212>  DNA

<213>  Homo sapiens



<400>  21
agttatagca tgaac                                                      15


<210>  22

<211>  5

<212>  PRT

<213>  Homo sapiens



<400>  22

Ser Tyr Ser Met Asn 
1               5   

<210>  23

<211>  33

<212>  DNA

<213>  Homo sapiens



<400>  23
cgggcaagtc agggcattag cagtgcttta gcc                                  33


<210>  24

<211>  11

<212>  PRT

<213>  Homo sapiens



<400>  24

Arg Ala Ser Gln Gly Ile Ser Ser Ala Leu Ala 
1               5                   10      

<210>  25

<211>  1131

<212>  DNA

<213>  Homo sapiens



<400>  25
gcctccacca agggcccatc ggtcttcccc ctggcgccct gctccaggag cacctctggg     60

ggcacagcgg ccctgggctg cctggtcaag gactacttcc ccgaaccggt gacggtgtcg    120

tggaactcag gcgccctgac cagcggcgtg cacaccttcc cggctgtcct acagtcctca    180

ggactctact ccctcagcag cgtggtgacc gtgccctcca gcagcttggg cacccagacc    240

tacacctgca acgtgaatca caagcccagc aacaccaagg tggacaagag agttgagctc    300

aaaaccccac ttggtgacac aactcacaca tgcccacggt gcccagagcc caaatcttgt    360

gacacacctc ccccgtgccc acggtgccca gagcccaaat cttgtgacac acctcccccg    420

tgcccacggt gcccagagcc caaatcttgt gacacacctc ccccatgccc acggtgccca    480

gcacctgaac tcctgggagg accgtcagtc ttcctcttcc ccccaaaacc caaggatacc    540

cttatgattt cccggacccc tgaggtcacg tgcgtggtgg tggacgtgag ccacgaagac    600

cccgaggtcc agttcaagtg gtacgtggac ggcgtggagg tgcataatgc caagacaaag    660

ccgcgggagg agcagttcaa cagcacgttc cgtgtggtca gcgtcctcac cgtcctgcac    720

caggactggc tgaacggcaa ggagtacaag tgcaaggtct ccaacaaagc cctcccagcc    780

cccatcgaga aaaccatctc caaaaccaaa ggacagcccc gagaaccaca ggtgtacacc    840

ctgcccccat cccgggagga gatgaccaag aaccaggtca gcctgacctg cctggtcaaa    900

ggcttctacc ccagcgacat cgccgtggag tgggagagca gcgggcagcc ggagaacaac    960

tacaacacca cgcctcccat gctggactcc gacggctcct tcttcctcta cagcaagctc   1020

accgtggaca agagcaggtg gcagcagggg aacatcttct catgctccgt gatgcatgag   1080

gctctgcaca accgcttcac gcagaagagc ctctccctgt ctccgggtaa a            1131


<210>  26

<211>  376

<212>  PRT

<213>  Homo sapiens



<400>  26

Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Cys Ser Arg 
1               5                   10                  15      

Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          

Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              

Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  

Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr 
65                  70                  75                  80  

Tyr Thr Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      

Arg Val Glu Leu Lys Thr Pro Leu Gly Asp Thr Thr His Thr Cys Pro 
            100                 105                 110         

Arg Cys Pro Glu Pro Lys Ser Cys Asp Thr Pro Pro Pro Cys Pro Arg 
        115                 120                 125             

Cys Pro Glu Pro Lys Ser Cys Asp Thr Pro Pro Pro Cys Pro Arg Cys 
    130                 135                 140                 

Pro Glu Pro Lys Ser Cys Asp Thr Pro Pro Pro Cys Pro Arg Cys Pro 
145                 150                 155                 160 

Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys 
                165                 170                 175     

Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val 
            180                 185                 190         

Val Val Asp Val Ser His Glu Asp Pro Glu Val Gln Phe Lys Trp Tyr 
        195                 200                 205             

Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu 
    210                 215                 220                 

Gln Phe Asn Ser Thr Phe Arg Val Val Ser Val Leu Thr Val Leu His 
225                 230                 235                 240 

Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys 
                245                 250                 255     

Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Thr Lys Gly Gln 
            260                 265                 270         

Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met 
        275                 280                 285             

Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro 
    290                 295                 300                 

Ser Asp Ile Ala Val Glu Trp Glu Ser Ser Gly Gln Pro Glu Asn Asn 
305                 310                 315                 320 

Tyr Asn Thr Thr Pro Pro Met Leu Asp Ser Asp Gly Ser Phe Phe Leu 
                325                 330                 335     

Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Ile 
            340                 345                 350         

Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn Arg Phe Thr Gln 
        355                 360                 365             

Lys Ser Leu Ser Leu Ser Pro Gly 
    370                 375     

<210>  27

<211>  29

<212>  DNA

<213>  Artificial



<220>

<223>  PCR primer for human NGF

<400>  27
acaccacata tgtcatcatc ccatcccat                                       29


<210>  28

<211>  40

<212>  DNA

<213>  Artificial



<220>

<223>  PCR Primer for human NGF

<400>  28
accacaggat cctccttatg cacgacgcac agctttacgg                           40


<210>  29

<211>  375

<212>  DNA

<213>  Artificial



<220>

<223>  Nucleotide sequence encoding recombinant human met-NGF

<400>  29
catatgtcat catcccatcc catcttccac aggggcgaat tctcggtgtg tgacagtgtc     60

agcgtgtggg ttggggataa gaccaccgcc acagacatca agggcaagga ggtgatggtg    120

ttgggagagg tgaacattaa caacagtgta ttcaaacagt acttttttga gaccaagtgc    180

cgggacccaa atcccgttga cagcgggtgc cggggcattg actcaaagca ctggaactca    240

tattgtacca cgactcacac ctttgtcaag gcgctgacca tggatggcaa gcaggctgcc    300

tggcggttta tccggataga tacggcctgt gtgtgtgtgc tcagccgtaa agctgtgcgt    360

cgtgcataag gatcc                                                     375


<210>  30

<211>  121

<212>  PRT

<213>  Artificial



<220>

<223>  amino acid sequence of recombinant human met-NGF (1-120)

<400>  30

Met Ser Ser Ser His Pro Ile Phe His Arg Gly Glu Phe Ser Val Cys 
1               5                   10                  15      

Asp Ser Val Ser Val Trp Val Gly Asp Lys Thr Thr Ala Thr Asp Ile 
            20                  25                  30          

Lys Gly Lys Glu Val Met Val Leu Gly Glu Val Asn Ile Asn Asn Ser 
        35                  40                  45              

Val Phe Lys Gln Tyr Phe Phe Glu Thr Lys Cys Arg Asp Pro Asn Pro 
    50                  55                  60                  

Val Asp Ser Gly Cys Arg Gly Ile Asp Ser Lys His Trp Asn Ser Tyr 
65                  70                  75                  80  

Cys Thr Thr Thr His Thr Phe Val Lys Ala Leu Thr Met Asp Gly Lys 
                85                  90                  95      

Gln Ala Ala Trp Arg Phe Ile Arg Ile Asp Thr Ala Cys Val Cys Val 
            100                 105                 110         

Leu Ser Arg Lys Ala Val Arg Arg Ala 
        115                 120     

<210>  31

<211>  55

<212>  DNA

<213>  Artificial



<220>

<223>  5' primer sequence to generate expression vector pCFM1656 (ATCC #
       69576

<400>  31
cgatttgatt ctagaaggag gaataacata tggttaacgc gttggaattc ggtac          55


<210>  32

<211>  49

<212>  DNA

<213>  Artificial



<220>

<223>  3' primer sequence to generate expression vector pCFM1656 (ATCC #
       69576

<400>  32
taaactaaga tcttcctcct tattgtatac caattgcgca accttaagc                 49


<210>  33

<211>  24

<212>  DNA

<213>  Artificial



<220>

<223>  PCR primer

<220>

<221>  Unsure

<222>  (18)..(23)

<223>  n is a, c, t, or g



<400>  33
ggccggatag gcctccannn nnnt                                            24


<210>  34

<211>  21

<212>  DNA

<213>  Artificial



<220>

<223>  PCR primer

<400>  34
ggggtcaggc tggaactgag g                                               21


<210>  35

<211>  19

<212>  DNA

<213>  Artificial



<220>

<223>  PCR primer

<400>  35
tgaggacgct gaccacacg                                                  19


<210>  36

<211>  54

<212>  DNA

<213>  Artificial



<220>

<223>  PCR primer

<400>  36
cagcagaagc ttctagacca ccatggacat gagggtgccc gctcagctcc tggg           54


<210>  37

<211>  34

<212>  DNA

<213>  Artificial



<220>

<223>  PCR primer

<400>  37
cttgtcgact caacactctc ccctgttgaa gctc                                 34


<210>  38

<211>  55

<212>  DNA

<213>  Artificial



<220>

<223>  PCR primer

<400>  38
cagcagaagc ttctagacca ccatggagtt ggggctgtgc tgggttttcc ttgtt          55


<210>  39

<211>  34

<212>  DNA

<213>  Artificial



<220>

<223>  PCR primer

<400>  39
gcatgtcgac tcatttaccc ggagacaggg agag                                 34


<210>  40

<211>  449

<212>  PRT

<213>  Homo sapiens



<400>  40

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      

Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Leu Arg Ser Tyr 
            20                  25                  30          

Ser Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              

Ser Tyr Ile Ser Arg Ser Ser His Thr Ile Phe Tyr Ala Asp Ser Val 
    50                  55                  60                  

Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  

Leu Gln Met Asp Ser Leu Arg Asp Glu Asp Thr Ala Met Tyr Tyr Cys 
                85                  90                  95      

Ala Arg Val Tyr Ser Ser Gly Trp His Val Ser Asp Tyr Phe Asp Tyr 
            100                 105                 110         

Trp Gly Gln Gly Ile Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly 
        115                 120                 125             

Pro Ser Val Phe Pro Leu Ala Pro Cys Ser Arg Ser Thr Ser Glu Ser 
    130                 135                 140                 

Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val 
145                 150                 155                 160 

Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe 
                165                 170                 175     

Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val 
            180                 185                 190         

Thr Val Pro Ser Ser Asn Phe Gly Thr Gln Thr Tyr Thr Cys Asn Val 
        195                 200                 205             

Asp His Lys Pro Ser Asn Thr Lys Val Asp Lys Thr Val Glu Arg Lys 
    210                 215                 220                 

Cys Cys Val Glu Cys Pro Pro Cys Pro Ala Pro Pro Val Ala Gly Pro 
225                 230                 235                 240 

Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser 
                245                 250                 255     

Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp 
            260                 265                 270         

Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn 
        275                 280                 285             

Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Phe Arg Val 
    290                 295                 300                 

Val Ser Val Leu Thr Val Val His Gln Asp Trp Leu Asn Gly Lys Glu 
305                 310                 315                 320 

Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro Ala Pro Ile Glu Lys 
                325                 330                 335     

Thr Ile Ser Lys Thr Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr 
            340                 345                 350         

Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr 
        355                 360                 365             

Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu 
    370                 375                 380                 

Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Met Leu 
385                 390                 395                 400 

Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys 
                405                 410                 415     

Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu 
            420                 425                 430         

Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
        435                 440                 445             

Lys 
    

<210>  41

<211>  453

<212>  PRT

<213>  Homo sapiens



<400>  41

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      

Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Leu Arg Ser Tyr 
            20                  25                  30          

Ser Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              

Ser Tyr Ile Ser Arg Ser Ser His Thr Ile Phe Tyr Ala Asp Ser Val 
    50                  55                  60                  

Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  

Leu Gln Met Asp Ser Leu Arg Asp Glu Asp Thr Ala Met Tyr Tyr Cys 
                85                  90                  95      

Ala Arg Val Tyr Ser Ser Gly Trp His Val Ser Asp Tyr Phe Asp Tyr 
            100                 105                 110         

Trp Gly Gln Gly Ile Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly 
        115                 120                 125             

Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly 
    130                 135                 140                 

Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val 
145                 150                 155                 160 

Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe 
                165                 170                 175     

Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val 
            180                 185                 190         

Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val 
        195                 200                 205             

Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys 
    210                 215                 220                 

Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu 
225                 230                 235                 240 

Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr 
                245                 250                 255     

Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val 
            260                 265                 270         

Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val 
        275                 280                 285             

Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser 
    290                 295                 300                 

Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu 
305                 310                 315                 320 

Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala 
                325                 330                 335     

Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro 
            340                 345                 350         

Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln 
        355                 360                 365             

Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala 
    370                 375                 380                 

Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr 
385                 390                 395                 400 

Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu 
                405                 410                 415     

Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser 
            420                 425                 430         

Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser 
        435                 440                 445             

Leu Ser Pro Gly Lys 
    450             

<210>  42

<211>  450

<212>  PRT

<213>  Homo sapiens



<400>  42

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      

Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Leu Arg Ser Tyr 
            20                  25                  30          

Ser Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              

Ser Tyr Ile Ser Arg Ser Ser His Thr Ile Phe Tyr Ala Asp Ser Val 
    50                  55                  60                  

Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  

Leu Gln Met Asp Ser Leu Arg Asp Glu Asp Thr Ala Met Tyr Tyr Cys 
                85                  90                  95      

Ala Arg Val Tyr Ser Ser Gly Trp His Val Ser Asp Tyr Phe Asp Tyr 
            100                 105                 110         

Trp Gly Gln Gly Ile Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly 
        115                 120                 125             

Pro Ser Val Phe Pro Leu Ala Pro Cys Ser Arg Ser Thr Ser Glu Ser 
    130                 135                 140                 

Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val 
145                 150                 155                 160 

Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe 
                165                 170                 175     

Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val 
            180                 185                 190         

Thr Val Pro Ser Ser Ser Leu Gly Thr Lys Thr Tyr Thr Cys Asn Val 
        195                 200                 205             

Asp His Lys Pro Ser Asn Thr Lys Val Asp Lys Arg Val Glu Ser Lys 
    210                 215                 220                 

Tyr Gly Pro Pro Cys Pro Ser Cys Pro Ala Pro Glu Phe Leu Gly Gly 
225                 230                 235                 240 

Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile 
                245                 250                 255     

Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser Gln Glu 
            260                 265                 270         

Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His 
        275                 280                 285             

Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg 
    290                 295                 300                 

Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys 
305                 310                 315                 320 

Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu 
                325                 330                 335     

Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr 
            340                 345                 350         

Thr Leu Pro Pro Ser Gln Glu Glu Met Thr Lys Asn Gln Val Ser Leu 
        355                 360                 365             

Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp 
    370                 375                 380                 

Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val 
385                 390                 395                 400 

Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp 
                405                 410                 415     

Lys Ser Arg Trp Gln Glu Gly Asn Val Phe Ser Cys Ser Val Met His 
            420                 425                 430         

Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Leu 
        435                 440                 445             

Gly Lys 
    450 

<210>  43

<211>  499

<212>  PRT

<213>  Homo sapiens



<400>  43

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      

Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Leu Arg Ser Tyr 
            20                  25                  30          

Ser Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              

Ser Tyr Ile Ser Arg Ser Ser His Thr Ile Phe Tyr Ala Asp Ser Val 
    50                  55                  60                  

Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  

Leu Gln Met Asp Ser Leu Arg Asp Glu Asp Thr Ala Met Tyr Tyr Cys 
                85                  90                  95      

Ala Arg Val Tyr Ser Ser Gly Trp His Val Ser Asp Tyr Phe Asp Tyr 
            100                 105                 110         

Trp Gly Gln Gly Ile Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly 
        115                 120                 125             

Pro Ser Val Phe Pro Leu Ala Pro Cys Ser Arg Ser Thr Ser Gly Gly 
    130                 135                 140                 

Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val 
145                 150                 155                 160 

Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe 
                165                 170                 175     

Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val 
            180                 185                 190         

Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Thr Cys Asn Val 
        195                 200                 205             

Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Arg Val Glu Leu Lys 
    210                 215                 220                 

Thr Pro Leu Gly Asp Thr Thr His Thr Cys Pro Arg Cys Pro Glu Pro 
225                 230                 235                 240 

Lys Ser Cys Asp Thr Pro Pro Pro Cys Pro Arg Cys Pro Glu Pro Lys 
                245                 250                 255     

Ser Cys Asp Thr Pro Pro Pro Cys Pro Arg Cys Pro Glu Pro Lys Ser 
            260                 265                 270         

Cys Asp Thr Pro Pro Pro Cys Pro Arg Cys Pro Ala Pro Glu Leu Leu 
        275                 280                 285             

Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu 
    290                 295                 300                 

Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser 
305                 310                 315                 320 

His Glu Asp Pro Glu Val Gln Phe Lys Trp Tyr Val Asp Gly Val Glu 
                325                 330                 335     

Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr 
            340                 345                 350         

Phe Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn 
        355                 360                 365             

Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro 
    370                 375                 380                 

Ile Glu Lys Thr Ile Ser Lys Thr Lys Gly Gln Pro Arg Glu Pro Gln 
385                 390                 395                 400 

Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val 
                405                 410                 415     

Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val 
            420                 425                 430         

Glu Trp Glu Ser Ser Gly Gln Pro Glu Asn Asn Tyr Asn Thr Thr Pro 
        435                 440                 445             

Pro Met Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr 
    450                 455                 460                 

Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Ile Phe Ser Cys Ser Val 
465                 470                 475                 480 

Met His Glu Ala Leu His Asn Arg Phe Thr Gln Lys Ser Leu Ser Leu 
                485                 490                 495     

Ser Pro Gly 
            

<210>  44

<211>  214

<212>  PRT

<213>  Homo sapiens



<400>  44

Ala Ile Gln Leu Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      

Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Ser Ser Ala 
            20                  25                  30          

Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              

Tyr Asp Ala Ser Ser Leu Glu Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  

Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  

Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Phe Asn Ser Tyr Pro Leu 
                85                  90                  95      

Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala Ala 
            100                 105                 110         

Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 
        115                 120                 125             

Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 
    130                 135                 140                 

Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 
145                 150                 155                 160 

Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 
                165                 170                 175     

Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 
            180                 185                 190         

Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 
        195                 200                 205             

Phe Asn Arg Gly Glu Cys 
    210                 

<210>  45

<211>  5

<212>  PRT

<213>  Homo sapiens



<400>  45

Phe Phe Glu Thr Lys 
1               5   

<210>  46

<211>  9

<212>  PRT

<213>  Homo sapiens



<400>  46

Ser Ser Ser His Pro Ile Phe His Arg 
1               5                   

<210>  47

<211>  5

<212>  PRT

<213>  Homo sapiens



<400>  47

His Trp Asn Ser Tyr 
1               5   

<210>  48

<211>  12

<212>  PRT

<213>  Homo sapiens



<400>  48

Asn Ser Val Glu Lys Gln Tyr Phe Phe Glu Thr Lys 
1               5                   10          

<210>  49

<211>  7

<212>  PRT

<213>  Homo sapiens



<400>  49

Ser Arg Lys Ala Val Arg Arg 
1               5           

<210>  50

<211>  5

<212>  PRT

<213>  Homo sapiens



<400>  50

Glu Val Met Val Leu 
1               5   

<210>  51

<211>  25

<212>  PRT

<213>  Homo sapiens



<400>  51

Ser Ser Ser His Pro Ile Phe His Arg Gly Glu Phe Ser Val Cys Asp 
1               5                   10                  15      

Ser Val Ser Val Trp Val Gly Asp Lys 
            20                  25  

<210>  52

<211>  20

<212>  PRT

<213>  Homo sapiens



<400>  52

Gln Ala Ala Trp Arg Phe Ile Arg Ile Asp Thr Ala Cys Val Cys Val 
1               5                   10                  15      

Leu Ser Arg Lys 
            20  

<210>  53

<211>  14

<212>  PRT

<213>  Homo sapiens



<400>  53

Ser Ser His Pro Ile Phe His Arg Gly Glu Phe Ser Val Cys 
1               5                   10                  

<210>  54

<211>  8

<212>  PRT

<213>  Homo sapiens



<400>  54

Ser Ser His Pro Ile Phe His Arg 
1               5               

<210>  55

<211>  6

<212>  PRT

<213>  Homo sapiens



<400>  55

Gly Glu Phe Ser Val Cys 
1               5       

<210>  56

<211>  15

<212>  PRT

<213>  Homo sapiens



<400>  56

Ser Ser Ser His Pro Ile Phe His Arg Gly Glu Phe Ser Val Cys 
1               5                   10                  15  

<210>  57

<211>  16

<212>  PRT

<213>  Homo sapiens



<400>  57

Ile Phe His Arg Gly Glu Phe Ser Val Ala Asp Ser Val Ser Val Cys 
1               5                   10                  15      

<210>  58

<211>  16

<212>  PRT

<213>  Homo sapiens



<400>  58

Glu Phe Ser Val Ala Asp Ser Val Ser Val Trp Val Gly Asp Lys Cys 
1               5                   10                  15      

<210>  59

<211>  16

<212>  PRT

<213>  Homo sapiens



<400>  59

Asp Ser Val Ser Val Trp Val Gly Asp Lys Thr Thr Ala Thr Asp Cys 
1               5                   10                  15      

<210>  60

<211>  16

<212>  PRT

<213>  Homo sapiens



<400>  60

Trp Val Gly Asp Lys Thr Thr Ala Thr Asp Ile Lys Gly Lys Glu Cys 
1               5                   10                  15      

<210>  61

<211>  16

<212>  PRT

<213>  Homo sapiens



<400>  61

Thr Thr Ala Thr Asp Ile Lys Gly Lys Glu Val Met Val Leu Gly Cys 
1               5                   10                  15      

<210>  62

<211>  15

<212>  PRT

<213>  Homo sapiens



<400>  62

Ile Lys Gly Lys Glu Val Met Val Leu Gly Glu Val Asn Ile Asn 
1               5                   10                  15  

<210>  63

<211>  16

<212>  PRT

<213>  Homo sapiens



<400>  63

Val Met Val Leu Gly Glu Val Asn Ile Asn Asn Ser Val Phe Lys Cys 
1               5                   10                  15      

<210>  64

<211>  16

<212>  PRT

<213>  Homo sapiens



<400>  64

Glu Val Asn Ile Asn Asn Ser Val Phe Lys Gln Tyr Phe Phe Glu Cys 
1               5                   10                  15      

<210>  65

<211>  16

<212>  PRT

<213>  Homo sapiens



<400>  65

Asn Ser Val Phe Lys Gln Tyr Phe Phe Glu Thr Lys Ala Arg Asp Cys 
1               5                   10                  15      

<210>  66

<211>  16

<212>  PRT

<213>  Homo sapiens



<400>  66

Gln Tyr Phe Phe Glu Thr Lys Ala Arg Asp Pro Asn Pro Val Asp Cys 
1               5                   10                  15      

<210>  67

<211>  16

<212>  PRT

<213>  Homo sapiens



<400>  67

Thr Lys Ala Arg Asp Pro Asn Pro Val Asp Ser Gly Ala Arg Asp Cys 
1               5                   10                  15      

<210>  68

<211>  16

<212>  PRT

<213>  Homo sapiens



<400>  68

Pro Asn Pro Val Asp Ser Gly Ala Arg Asp Ile Asp Ser Lys His Cys 
1               5                   10                  15      

<210>  69

<211>  15

<212>  PRT

<213>  Homo sapiens



<400>  69

Ser Gly Ala Arg Asp Ile Asp Ser Lys His Trp Asn Ser Tyr Cys 
1               5                   10                  15  

<210>  70

<211>  16

<212>  PRT

<213>  Homo sapiens



<400>  70

Ile Asp Ser Lys His Trp Asn Ser Tyr Ala Thr Thr Thr His Thr Cys 
1               5                   10                  15      

<210>  71

<211>  16

<212>  PRT

<213>  Homo sapiens



<400>  71

Trp Asn Ser Tyr Ala Thr Thr Thr His Thr Phe Val Lys Ala Leu Cys 
1               5                   10                  15      

<210>  72

<211>  16

<212>  PRT

<213>  Homo sapiens



<400>  72

Thr Thr Thr His Thr Phe Val Lys Ala Leu Thr Met Asp Gly Lys Cys 
1               5                   10                  15      

<210>  73

<211>  16

<212>  PRT

<213>  Homo sapiens



<400>  73

Phe Val Lys Ala Leu Thr Met Asp Gly Lys Gln Ala Ala Trp Arg Cys 
1               5                   10                  15      

<210>  74

<211>  16

<212>  PRT

<213>  Homo sapiens



<400>  74

Thr Met Asp Gly Lys Gln Ala Ala Trp Arg Phe Ile Arg Ile Asp Cys 
1               5                   10                  15      

<210>  75

<211>  15

<212>  PRT

<213>  Homo sapiens



<400>  75

Gln Ala Ala Trp Arg Phe Ile Arg Ile Asp Thr Ala Ala Val Cys 
1               5                   10                  15  

<210>  76

<211>  16

<212>  PRT

<213>  Homo sapiens



<400>  76

Phe Ile Arg Ile Asp Thr Ala Ala Val Ala Val Leu Ser Arg Lys Cys 
1               5                   10                  15      

<210>  77

<211>  16

<212>  PRT

<213>  Homo sapiens



<400>  77

Thr Ala Ala Val Ala Val Leu Ser Arg Lys Ala Val Arg Arg Ala Cys 
1               5                   10                  15      

<210>  78

<211>  15

<212>  PRT

<213>  Homo sapiens



<400>  78

Cys Ala Ala Val Ala Val Leu Ser Arg Lys Ala Val Arg Arg Ala 
1               5                   10                  15  

<210>  79

<211>  125

<212>  PRT

<213>  homo sapien



<400>  79

Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Glu 
1               5                   10                  15      

Ser Leu Lys Ile Ser Cys Lys Gly Ser Gly Tyr Asn Phe Thr Thr Tyr 
            20                  25                  30          

Trp Ile Gly Trp Val Arg Gln Met Pro Gly Lys Gly Leu Glu Trp Met 
        35                  40                  45              

Gly Ile Ile Tyr Pro Gly Asp Ser Asp Thr Lys Tyr Ser Pro Ser Phe 
    50                  55                  60                  

Gln Gly Gln Val Thr Ile Ser Ala Asp Lys Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  

Leu Gln Trp Ser Ser Leu Lys Ala Ser Asp Thr Ala Met Tyr Tyr Cys 
                85                  90                  95      

Ala Arg Asn Tyr Tyr Gly Ser Gly Thr Tyr Tyr Tyr Tyr Tyr Gly Met 
            100                 105                 110         

Asn Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 
        115                 120                 125 

<210>  80

<211>  107

<212>  PRT

<213>  homo sapien



<400>  80

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Val Ser Ala Ser Val Gly 
1               5                   10                  15      

Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Ser Ile Trp 
            20                  25                  30          

Leu Ala Trp Tyr Gln His Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              

Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  

Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  

Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ala Asn Ser Phe Pro Trp 
                85                  90                  95      

Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105         

<210>  81

<211>  127

<212>  PRT

<213>  homo sapien



<400>  81

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Arg 
1               5                   10                  15      

Ser Leu Arg Leu Ser Cys Thr Ala Ser Gly Phe Thr Phe Glu Asp Tyr 
            20                  25                  30          

Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              

Ser Gly Ile Ser Trp Asn Arg Gly Ile Ile Gly Tyr Ala Asp Ser Val 
    50                  55                  60                  

Lys Gly Arg Phe Thr Val Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  

Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Leu Tyr Tyr Cys 
                85                  90                  95      

Ala Lys Glu Gly Tyr Tyr Gly Ser Gly Arg Pro Gly Tyr Phe Tyr Tyr 
            100                 105                 110         

Val Met Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 
        115                 120                 125         

<210>  82

<211>  108

<212>  PRT

<213>  homo sapien



<400>  82

Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      

Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Gly 
            20                  25                  30          

Phe Leu Ala Trp Phe Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu 
        35                  40                  45              

Ile Tyr Gly Ala Ser Ser Arg Ala Thr Ala Ile Pro Asp Arg Phe Ser 
    50                  55                  60                  

Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu 
65                  70                  75                  80  

Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Gly Ser Ser Pro 
                85                  90                  95      

Tyr Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105             

<210>  83

<211>  127

<212>  PRT

<213>  homo sapien



<400>  83

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Arg 
1               5                   10                  15      

Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ile Phe Asp Asp Tyr 
            20                  25                  30          

Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              

Ser Gly Ile Ser Trp Asn Arg Gly Ile Ile Gly Tyr Ala Gly Ser Val 
    50                  55                  60                  

Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  

Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Leu Tyr Tyr Cys 
                85                  90                  95      

Val Lys Glu Gly Tyr Tyr Gly Ser Gly Arg Pro Gly Tyr Phe Tyr Tyr 
            100                 105                 110         

Val Met Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 
        115                 120                 125         

<210>  84

<211>  108

<212>  PRT

<213>  homo sapien



<400>  84

Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      

Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Ser 
            20                  25                  30          

Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu 
        35                  40                  45              

Ile Tyr Val Ala Ser Ser Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser 
    50                  55                  60                  

Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu 
65                  70                  75                  80  

Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Gly Ser Ser Pro 
                85                  90                  95      

Tyr Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105             

<210>  85

<211>  121

<212>  PRT

<213>  homo sapien



<400>  85

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Arg 
1               5                   10                  15      

Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ile Phe Asp Asp Tyr 
            20                  25                  30          

Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              

Ser Gly Ile Thr Trp Asn Ser Gly Ile Leu Gly Tyr Ala Asp Ser Val 
    50                  55                  60                  

Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  

Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Leu Tyr Tyr Cys 
                85                  90                  95      

Ala Lys Glu Glu Gly Ser Gly Arg Tyr Tyr Asn Phe Asp Tyr Trp Gly 
            100                 105                 110         

Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120     

<210>  86

<211>  107

<212>  PRT

<213>  homo sapien



<400>  86

Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      

Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Ser 
            20                  25                  30          

Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu 
        35                  40                  45              

Ile Tyr Gly Ala Ser Ser Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser 
    50                  55                  60                  

Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu 
65                  70                  75                  80  

Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Gly Ser Ser Tyr 
                85                  90                  95      

Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105         

<210>  87

<211>  124

<212>  PRT

<213>  homo sapien



<400>  87

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Arg Pro Gly Gly 
1               5                   10                  15      

Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Asp Tyr 
            20                  25                  30          

Gly Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              

Ser Asp Ile Asn Trp Asn Gly Gly Ser Thr Gly Tyr Ala Asp Ser Val 
    50                  55                  60                  

Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  

Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Leu Tyr Tyr Cys 
                85                  90                  95      

Ala Arg Glu Gln Trp Leu Asp Pro Tyr Tyr Tyr Tyr Tyr Gly Met Asp 
            100                 105                 110         

Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 
        115                 120                 

<210>  88

<211>  107

<212>  PRT

<213>  homo sapien



<400>  88

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      

Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Ser Ser Trp 
            20                  25                  30          

Leu Ala Trp Tyr Gln Gln Lys Pro Glu Lys Ala Pro Lys Ser Leu Ile 
        35                  40                  45              

Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  

Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  

Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Asn Ser Tyr Pro Trp 
                85                  90                  95      

Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105         

<210>  89

<211>  107

<212>  PRT

<213>  homo sapien



<400>  89

Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      

Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Gly Val Ser Ser Tyr 
            20                  25                  30          

Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile 
        35                  40                  45              

Tyr Asp Ala Ser Asn Arg Ala Thr Gly Ile Pro Ala Arg Phe Ser Gly 
    50                  55                  60                  

Ser Gly Pro Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Glu Pro 
65                  70                  75                  80  

Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Arg Ser Asn Trp His Arg 
                85                  90                  95      

Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105         

<210>  90

<211>  108

<212>  PRT

<213>  homo sapien



<400>  90

Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      

Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Ser 
            20                  25                  30          

Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu 
        35                  40                  45              

Ile Tyr Gly Ala Ser Ser Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser 
    50                  55                  60                  

Gly Ser Gly Ser Gly Thr Gly Phe Thr Leu Thr Ile Ser Ser Leu Glu 
65                  70                  75                  80  

Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Asn Ser Tyr Pro 
                85                  90                  95      

Trp Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105             

<210>  91

<211>  107

<212>  PRT

<213>  homo sapien



<400>  91

Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      

Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Tyr 
            20                  25                  30          

Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile 
        35                  40                  45              

Tyr Asp Ala Ser Asn Arg Ala Thr Gly Ile Pro Ala Arg Phe Ser Gly 
    50                  55                  60                  

Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Glu Pro 
65                  70                  75                  80  

Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Arg Ser Asn Trp Pro Trp 
                85                  90                  95      

Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105         

<210>  92

<211>  5

<212>  PRT

<213>  homo sapien



<400>  92

Thr Tyr Trp Ile Gly 
1               5   

<210>  93

<211>  17

<212>  PRT

<213>  homo sapien



<400>  93

Ile Ile Tyr Pro Gly Asp Ser Asp Thr Lys Tyr Ser Pro Ser Phe Gln 
1               5                   10                  15      

Gly 
    

<210>  94

<211>  16

<212>  PRT

<213>  homo sapien



<400>  94

Asn Tyr Tyr Gly Ser Gly Thr Tyr Tyr Tyr Tyr Tyr Gly Met Asn Val 
1               5                   10                  15      

<210>  95

<211>  11

<212>  PRT

<213>  homo sapien



<400>  95

Arg Ala Ser Gln Gly Ile Ser Ile Trp Leu Ala 
1               5                   10      

<210>  96

<211>  7

<212>  PRT

<213>  homo sapien



<400>  96

Ala Ala Ser Ser Leu Gln Ser 
1               5           

<210>  97

<211>  9

<212>  PRT

<213>  homo sapien



<400>  97

Gln Gln Ala Asn Ser Phe Pro Trp Thr 
1               5                   

<210>  98

<211>  5

<212>  PRT

<213>  homo sapien



<400>  98

Asp Tyr Ala Met His 
1               5   

<210>  99

<211>  17

<212>  PRT

<213>  homo sapien



<400>  99

Gly Ile Ser Trp Asn Arg Gly Ile Ile Gly Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      

Gly 
    

<210>  100

<211>  17

<212>  PRT

<213>  homo sapien



<400>  100

Gly Tyr Tyr Gly Ser Gly Arg Pro Gly Tyr Phe Tyr Tyr Val Met Asp 
1               5                   10                  15      

Val 
    

<210>  101

<211>  12

<212>  PRT

<213>  homo sapien



<400>  101

Arg Ala Ser Gln Ser Val Ser Ser Gly Phe Leu Ala 
1               5                   10          

<210>  102

<211>  7

<212>  PRT

<213>  homo sapien



<400>  102

Gly Ala Ser Ser Arg Ala Thr 
1               5           

<210>  103

<211>  9

<212>  PRT

<213>  homo sapien



<400>  103

Gln Gln Tyr Gly Ser Ser Pro Tyr Thr 
1               5                   

<210>  104

<211>  5

<212>  PRT

<213>  homo sapien



<400>  104

Asp Tyr Ala Met His 
1               5   

<210>  105

<211>  17

<212>  PRT

<213>  homo sapien



<400>  105

Gly Ile Ser Trp Asn Arg Gly Ile Ile Gly Tyr Ala Gly Ser Val Lys 
1               5                   10                  15      

Gly 
    

<210>  106

<211>  17

<212>  PRT

<213>  homo sapien



<400>  106

Gly Tyr Tyr Gly Ser Gly Arg Pro Gly Tyr Phe Tyr Tyr Val Met Asp 
1               5                   10                  15      

Val 
    

<210>  107

<211>  12

<212>  PRT

<213>  homo sapien



<400>  107

Arg Ala Ser Gln Ser Val Ser Ser Ser Tyr Leu Ala 
1               5                   10          

<210>  108

<211>  7

<212>  PRT

<213>  homo sapien



<400>  108

Val Ala Ser Ser Arg Ala Thr 
1               5           

<210>  109

<211>  9

<212>  PRT

<213>  homo sapien



<400>  109

Gln Gln Tyr Gly Ser Ser Pro Tyr Thr 
1               5                   

<210>  110

<211>  5

<212>  PRT

<213>  homo sapien



<400>  110

Asp Tyr Ala Met His 
1               5   

<210>  111

<211>  17

<212>  PRT

<213>  homo sapien



<400>  111

Gly Ile Thr Trp Asn Ser Gly Ile Leu Gly Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      

Gly 
    

<210>  112

<211>  11

<212>  PRT

<213>  homo sapien



<400>  112

Glu Gly Ser Gly Arg Tyr Tyr Asn Phe Asp Tyr 
1               5                   10      

<210>  113

<211>  12

<212>  PRT

<213>  homo sapien



<400>  113

Arg Ala Ser Gln Ser Val Ser Ser Ser Tyr Leu Ala 
1               5                   10          

<210>  114

<211>  7

<212>  PRT

<213>  homo sapien



<400>  114

Gly Ala Ser Ser Arg Ala Thr 
1               5           

<210>  115

<211>  8

<212>  PRT

<213>  homo sapien



<400>  115

Gln Gln Tyr Gly Ser Ser Tyr Thr 
1               5               

<210>  116

<211>  5

<212>  PRT

<213>  homo sapien



<400>  116

Asp Tyr Gly Met Asn 
1               5   

<210>  117

<211>  17

<212>  PRT

<213>  homo sapien



<400>  117

Asp Ile Asn Trp Asn Gly Gly Ser Thr Gly Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      

Gly 
    

<210>  118

<211>  15

<212>  PRT

<213>  homo sapien



<400>  118

Glu Gln Trp Leu Asp Pro Tyr Tyr Tyr Tyr Tyr Gly Met Asp Val 
1               5                   10                  15  

<210>  119

<211>  11

<212>  PRT

<213>  homo sapien



<400>  119

Arg Ala Ser Gln Gly Ile Ser Ser Trp Leu Ala 
1               5                   10      

<210>  120

<211>  7

<212>  PRT

<213>  homo sapien



<400>  120

Ala Ala Ser Ser Leu Gln Ser 
1               5           

<210>  121

<211>  9

<212>  PRT

<213>  homo sapien



<400>  121

Gln Gln Tyr Asn Ser Tyr Pro Trp Thr 
1               5                   

<210>  122

<211>  11

<212>  PRT

<213>  homo sapien



<400>  122

Arg Ala Ser Gln Gly Val Ser Ser Tyr Leu Ala 
1               5                   10      

<210>  123

<211>  7

<212>  PRT

<213>  homo sapien



<400>  123

Asp Ala Ser Asn Arg Ala Thr 
1               5           

<210>  124

<211>  9

<212>  PRT

<213>  homo sapien



<400>  124

Gln Gln Arg Ser Asn Trp His Arg Thr 
1               5                   

<210>  125

<211>  12

<212>  PRT

<213>  homo sapien



<400>  125

Arg Ala Ser Gln Ser Val Ser Ser Ser Tyr Leu Ala 
1               5                   10          

<210>  126

<211>  7

<212>  PRT

<213>  homo sapien



<400>  126

Gly Ala Ser Ser Arg Ala Thr 
1               5           

<210>  127

<211>  9

<212>  PRT

<213>  homo sapien



<400>  127

Gln Gln Tyr Asn Ser Tyr Pro Trp Thr 
1               5                   

<210>  128

<211>  11

<212>  PRT

<213>  homo sapien



<400>  128

Arg Ala Ser Gln Ser Val Ser Ser Tyr Leu Ala 
1               5                   10      

<210>  129

<211>  7

<212>  PRT

<213>  homo sapien



<400>  129

Asp Ala Ser Asn Arg Ala Thr 
1               5           

<210>  130

<211>  9

<212>  PRT

<213>  homo sapien



<400>  130

Gln Gln Arg Ser Asn Trp Pro Trp Thr 
1               5                   

<210>  131

<211>  108

<212>  PRT

<213>  homo sapien



<400>  131

Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      

Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Ser 
            20                  25                  30          

Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu 
        35                  40                  45              

Ile Tyr Gly Ala Ser Ser Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser 
    50                  55                  60                  

Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu 
65                  70                  75                  80  

Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Gly Ser Ser Pro 
                85                  90                  95      

Tyr Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105             

<210>  132

<211>  11

<212>  PRT

<213>  homo sapien



<400>  132

Arg Ala Ser Gln Gly Val Ser Ser Tyr Leu Ala 
1               5                   10      

<210>  133

<211>  7

<212>  PRT

<213>  homo sapien



<400>  133

Gly Ala Ser Ser Arg Ala Thr 
1               5           

<210>  134

<211>  9

<212>  PRT

<213>  homo sapien



<400>  134

Gln Gln Tyr Gly Ser Ser Pro Tyr Thr 
1               5                   

<210>  135

<211>  120

<212>  PRT

<213>  homo sapien



<400>  135

Ser Ser Ser His Pro Ile Phe His Arg Gly Glu Phe Ser Val Cys Asp 
1               5                   10                  15      

Ser Val Ser Val Trp Val Gly Asp Lys Thr Thr Ala Thr Asp Ile Lys 
            20                  25                  30          

Gly Lys Glu Val Met Val Leu Gly Glu Val Asn Ile Asn Asn Ser Val 
        35                  40                  45              

Phe Lys Gln Tyr Phe Phe Glu Thr Lys Cys Arg Asp Pro Asn Pro Val 
    50                  55                  60                  

Asp Ser Gly Cys Arg Gly Ile Asp Ser Lys His Trp Asn Ser Tyr Cys 
65                  70                  75                  80  

Thr Thr Thr His Thr Phe Val Lys Ala Leu Thr Met Asp Gly Lys Gln 
                85                  90                  95      

Ala Ala Trp Arg Phe Ile Arg Ile Asp Thr Ala Cys Val Cys Val Leu 
            100                 105                 110         

Ser Arg Lys Ala Val Arg Arg Ala 
        115                 120 

<210>  136

<211>  120

<212>  PRT

<213>  mus musculus



<400>  136

Ser Ser Thr His Pro Val Phe His Met Gly Glu Phe Ser Val Cys Asp 
1               5                   10                  15      

Ser Val Ser Val Trp Val Gly Asp Lys Thr Thr Ala Thr Asp Ile Lys 
            20                  25                  30          

Gly Lys Glu Val Thr Val Leu Ala Glu Val Asn Ile Asn Asn Ser Val 
        35                  40                  45              

Phe Arg Gln Tyr Phe Phe Glu Thr Lys Cys Arg Ala Ser Asn Pro Val 
    50                  55                  60                  

Glu Ser Gly Cys Arg Gly Ile Asp Ser Lys His Trp Asn Ser Tyr Cys 
65                  70                  75                  80  

Thr Thr Thr His Thr Phe Val Lys Ala Leu Thr Thr Asp Glu Lys Gln 
                85                  90                  95      

Ala Ala Trp Arg Phe Ile Arg Ile Asp Thr Ala Cys Val Cys Val Leu 
            100                 105                 110         

Ser Arg Lys Ala Thr Arg Arg Ala 
        115                 120 

<210>  137

<211>  126

<212>  PRT

<213>  homo sapien



<400>  137

His Ser Asp Pro Ala Arg Arg His Ser Asp Pro Ala Arg Arg Gly Glu 
1               5                   10                  15      

Leu Ser Val Cys Asp Ser Ile Ser Glu Trp Val Thr Ala Ala Asp Lys 
            20                  25                  30          

Lys Thr Ala Val Asp Met Ser Gly Gly Thr Val Thr Val Leu Glu Lys 
        35                  40                  45              

Val Pro Val Ser Lys Gly Gln Leu Lys Gln Tyr Phe Tyr Glu Thr Lys 
    50                  55                  60                  

Cys Asn Pro Met Gly Tyr Thr Lys Glu Gly Cys Arg Gly Ile Asp Lys 
65                  70                  75                  80  

Arg His Trp Asn Ser Gln Cys Arg Thr Thr Gln Ser Tyr Val Arg Ala 
                85                  90                  95      

Leu Thr Met Asp Ser Lys Lys Arg Ile Gly Trp Arg Phe Ile Arg Ile 
            100                 105                 110         

Asp Thr Ser Cys Val Cys Thr Leu Thr Ile Lys Arg Gly Arg 
        115                 120                 125     

<210>  138

<211>  119

<212>  PRT

<213>  homo sapien



<400>  138

Tyr Ala Glu His Lys Ser His Arg Gly Glu Tyr Ser Val Cys Asp Ser 
1               5                   10                  15      

Glu Ser Leu Trp Val Thr Asp Lys Ser Ser Ala Ile Asp Ile Arg Gly 
            20                  25                  30          

His Gln Val Thr Val Leu Gly Glu Ile Lys Thr Gly Asn Ser Pro Val 
        35                  40                  45              

Lys Gln Tyr Phe Tyr Glu Thr Arg Cys Lys Glu Ala Arg Pro Val Lys 
    50                  55                  60                  

Asn Gly Cys Arg Gly Ile Asp Asp Lys His Trp Asn Ser Gln Cys Lys 
65                  70                  75                  80  

Thr Ser Gln Thr Tyr Val Arg Ala Leu Thr Ser Glu Asn Asn Lys Leu 
                85                  90                  95      

Val Gly Trp Arg Trp Ile Arg Ile Asp Thr Ser Cys Val Cys Ala Leu 
            100                 105                 110         

Ser Arg Lys Ile Gly Arg Thr 
        115                 

